A new clue at the nuclear pore: RanBP2 is an E3 enzyme for SUMO1.
A recent paper in Cell shows that the large nucleoporin RanBP2 can act as an E3 enzyme for the ubiquitin-like protein SUMO1. These intriguing results raise important questions about the mechanism of SUMO1 conjugation, the relationship of SUMO1 to nuclear transport, and the regulation of RanBP2 in the pore.
Azuma
Yoshiaki
Y
Laboratory of Gene Regulation and Development, NICHD/NIH, Building 18, Room 106, Bethesda, MD 20892, USA.
Dasso
Mary
M
D021581:Active Transport, Cell Nucleus; D018832:Molecular Chaperones; D022022:Nuclear Pore / Q000201:enzymology / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism*; D025842:SUMO-1 Protein / Q000378:metabolism*
D018832:Molecular Chaperones; D028861:Nuclear Pore Complex Proteins; D025842:SUMO-1 Protein; C094493:ran-binding protein 2