title: Cyclin D1 overexpression is more prevalent in non-Caucasian breast cancer.
abstract: African-American women with breast cancer consistently show a shortened survival when compared with Caucasians with breast cancer, however it is not clear whether this is due to socioeconomic factors or to racial differences in tumor biology. Cyclin D1 overexpression has been demonstrated in 60-80% of female breast cancers, however these studies have not included race or ethnicity data. We examined the level of cyclin D1 protein expression in 139 cases of female breast cancer obtained from different ethnic populations. Using an immunoperoxidase-based technique and a polyclonal anti-cyclin D1 antibody, the rate of overexpression was 68%. Cyclin D1 overexpression tended to be more frequent in cases from non-Caucasian patients when compared with those from Caucasian patients (77% vs. 59%, p=0.051). Our findings suggest that non-Caucasian ethnicity may be important in predicting cyclin D1 overexpression. Cyclin D1 could therefore serve as a possible target in managing breast cancer in the African-American population.
authors.affiliation: Herbert Irving Comprehensive Cancer Center, and Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Joe
authors.forename: N
authors.initials: N
authors.lastname: Arber
authors.forename: S
authors.initials: S
authors.lastname: Bose
authors.forename: D
authors.initials: D
authors.lastname: Heitjan
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: I B
authors.initials: IB
authors.lastname: Weinstein
authors.forename: H
authors.initials: H
authors.lastname: Hibshoosh
mesh_terms: D044383:Black People; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002467:Cell Nucleus / Q000378:metabolism; D019938:Cyclin D1 / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D011003:Ploidies; D011960:Receptors, Estrogen / Q000502:physiology; D001741:Black or African American
chemical_list: D011960:Receptors, Estrogen; D019938:Cyclin D1