title: Signal transduction and the control of gene expression.
abstract: More than 2000 transcription factors are encoded in the human genome. Such proteins have often been classified according to common structural elements. But because transcription factors evolved in the service of biologic function, we propose an alternative grouping of eukaryotic transcription factors on the basis of characteristics that describe their roles within cellular regulatory circuits.
authors.affiliation: Laboratory of Molecular Vertebrate Embryology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
authors.forename: Ali H
authors.initials: AH
authors.lastname: Brivanlou
authors.forename: James E
authors.initials: JE
authors.lastname: Darnell
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D010766:Phosphorylation; D010768:Phosphoserine / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D015290:Second Messenger Systems; D015398:Signal Transduction; D014157:Transcription Factors / Q000737:chemistry / Q000145:classification* / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D011956:Receptors, Cell Surface; D014157:Transcription Factors; D010768:Phosphoserine; D004247:DNA