Severe systemic effects with topical fluorouracil.
Even if the approved dose regimen is followed, use of fluorouracil cream on the skin carries a risk of severe systemic effects in some patients.
D000287:Administration, Topical; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D005602:France
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil