title: In vivo drug target discovery: identifying the best targets from the genome.
abstract: A vast number of genes of unknown function threaten to clog drug discovery pipelines. To develop therapeutic products from novel genomic targets, it will be necessary to correlate biology with gene sequence information. Industrialized mouse reverse genetics is being used to determine gene function in the context of mammalian physiology and to identify the best targets for drug development.
authors.affiliation: Lexicon Genetics Incorporated, 4000 Research Forest Drive, The Woodlands, TX 77381, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Walke
authors.forename: C
authors.initials: C
authors.lastname: Han
authors.forename: J
authors.initials: J
authors.lastname: Shaw
authors.forename: E
authors.initials: E
authors.lastname: Wann
authors.forename: B
authors.initials: B
authors.lastname: Zambrowicz
authors.forename: A
authors.initials: A
authors.lastname: Sands
mesh_terms: D000818:Animals; D001331:Automation; D019295:Computational Biology; D004345:Drug Industry / Q000379:methods; D015723:Gene Library; D005821:Genetic Techniques; D016678:Genome; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D012984:Software