title: Segmental duplications and the evolution of the primate genome.
abstract: Initial human genome sequence analysis has revealed large segments of nearly identical sequence in particular chromosomal regions. The recent origin of these segments and their abundance (approximately 5%) has challenged investigators to elucidate their underlying mechanism and role in primate genome evolution. Although the precise fraction is unknown, some of these duplicated segments have recently been shown to be associated with rapid gene innovation and chromosomal rearrangement in the genomes of man and the great apes.
authors.affiliation: Department of Genetics and Center for Human Genetics, School of Medicine and University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA. eee@po.cwru.edu
authors.forename: Rhea Vallente
authors.initials: RV
authors.lastname: Samonte
authors.forename: Evan E
authors.initials: EE
authors.lastname: Eichler
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002877:Chromosomes, Human / Q000235:genetics*; D019143:Evolution, Molecular; D005091:Exons; D020440:Gene Duplication; D015894:Genome, Human; D000882:Haplorhini / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011123:Polyploidy; D017386:Sequence Homology, Amino Acid