title: [Expression and significance of Fas/APO-1 and bcl-2 protein in renal cell carcinoma].
abstract: OBJECTIVE
  To investigate the role of Fas/APO-1 and bcl-2 in occurrence and progression of renal cell carcinoma.
  
  
  METHODS
  Immunohistochemistry method was used to detect the expression of Fas/APO-1 and bcl-2 protein in 35 cases of renal cell carcinoma tissues and 26 cases of normal renal tissues.
  
  
  RESULTS
  The expression rate of Fas/APO-1 protein in renal cell carcinoma tissues was 57.14%, significantly lower than that in normal renal tissues (84.62%) (P < 0.05), and the intensity of expression was also lower. The expression rate of bcl-2 protein reached 80.00%, much higher than that in normal renal tissues (53.85%) (P < 0.05).
  
  
  CONCLUSIONS
  Both Fas/APO-1 and bcl-2 take part in the occurrence and progression of renal cell carcinoma.
authors.affiliation: Institute of Urology, First Teaching Hospital, Beijing Medical University, Beijing 100034.
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Yu
authors.forename: B
authors.initials: B
authors.lastname: Yang
authors.forename: X
authors.initials: X
authors.lastname: Kong
authors.forename: P
authors.initials: P
authors.lastname: Mi
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D019014:fas Receptor / Q000096:biosynthesis*
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor