title: Clinical evaluation of anorganic bovine bone xenograft with a bioabsorbable collagen barrier in the treatment of molar furcation defects.
abstract: The purpose of this study was to compare Bio-Oss (BO), an anorganic bovine bone xenograft, in combination with Bio-Gide (BG), a bioabsorbable collagen barrier, to open-flap debridement (OFD) surgery in human mandibular Class II furcation defects. A total of 31 furcations (18 treatment, 13 control) in 21 patients were treated. There was a statistically significant improvement in most clinical indices for the BO/BG group, with minimal improvement noted for the OFD group. Vertical probing depth reduction of 2.0 mm and horizontal probing depth reduction of 2.2 mm were noted for the BO/BG group, with 0.3 mm and 0.2 mm reductions, respectively, noted for OFD. Hard tissue measurements showed 2.0 mm of vertical furcation bone fill for BO/BG and 0.5 mm for OFD. The BO/BG group had 3.0 mm of horizontal furcation bone fill, and the OFD group had 0.9 mm. The BO/BG group had a defect resolution of 82.7%; 42.5% was noted for the OFD group. There was a statistically significant difference between BO/BG and OFD in all soft and hard tissue measurements with the exception of attachment level, recession, and alveolar crest resorption.
authors.affiliation: Department of Periodontics, The University of Texas Health Science Center at San Antonio, 78284-7894, USA.
authors.forename: B E
authors.initials: BE
authors.lastname: Houser
authors.forename: J T
authors.initials: JT
authors.lastname: Mellonig
authors.forename: M A
authors.initials: MA
authors.lastname: Brunsvold
authors.forename: D L
authors.initials: DL
authors.lastname: Cochran
authors.forename: R M
authors.initials: RM
authors.lastname: Meffert
authors.forename: M E
authors.initials: ME
authors.lastname: Alder
mesh_terms: D020341:Absorbable Implants; D000539:Alveolar Process / Q000473:pathology; D000704:Analysis of Variance; D000818:Animals; D001857:Bone Matrix / Q000637:transplantation*; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D003094:Collagen / Q000627:therapeutic use*; D003646:Debridement; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000145:classification / Q000473:pathology / Q000601:surgery*; D005889:Gingival Recession / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008334:Mandible / Q000473:pathology / Q000601:surgery; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use*; D008963:Molar / Q000473:pathology / Q000601:surgery*; D017622:Periodontal Attachment Loss / Q000473:pathology / Q000601:surgery; D016037:Single-Blind Method; D013223:Statistics as Topic; D013524:Surgical Flaps; D014183:Transplantation, Heterologous; D016896:Treatment Outcome
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen