title: Interleukin 8 and venous thrombosis: evidence for a role of inflammation in thrombosis.
abstract: Elevated plasma levels of interleukin 8 (IL-8) were previously shown to be associated with recurrent venous thrombosis. To assess the risk of venous thrombosis, IL-8 plasma concentrations were measured in patients and control subjects of the Leiden Thrombophilia Study (LETS). This population based case-control study included 474 patients with a first deep-vein thrombosis and 474 age- and sex-matched controls. The risk of venous thrombosis for subjects with elevated IL-8 levels (above 90th percentile of controls) compared with subjects with IL-8 levels below the 90th percentile was increased 1.8-fold (95%CI 1.2-2.8). Adjusted for age and sex, the odds ratio was 1.9 (95%CI 1.3-2.8). IL-8 concentrations were weakly correlated with age, male sex, and concentrations of C-reactive protein, factor VIII coagulation activity and homocysteine, but adjustment for these factors did not substantially affect the association between IL-8 and venous thrombosis. Our results suggest that IL-8 is a risk factor for venous thrombosis.
authors.affiliation: Laboratory for Experimental Internal Medicine and Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Benien E
authors.initials: BE
authors.lastname: van Aken
authors.forename: Pieter H
authors.initials: PH
authors.lastname: Reitsma
authors.forename: Frits R
authors.initials: FR
authors.lastname: Rosendaal
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012306:Risk; D012307:Risk Factors; D012737:Sex Factors; D020246:Venous Thrombosis / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000925:Anticoagulants; D016209:Interleukin-8; D006710:Homocysteine; D005169:Factor VIII; D002097:C-Reactive Protein