Gene targeting of components of the fibrinolytic system.
A number of in vitro and in vivo observations have implicated components of the fibrinolytic system in events associated with diverse physiological and pathophysiological processes, ranging from embryo implantation to cancer. Advances in gene targeting technology have led to the generation of mice deficient for components of the fibrinolytic system. Remarkably, these animals survive to adulthood with few spontaneous life threatening events. Thus, these mice are valuable resources for in vivo studies, not only for hemostasis-related research, but also for the relationships of these genes to other disease states associated with cellular growth and mobility, along with angiogenesis, vascular remodeling, inflammation, wound healing, and tumor growth and dissemination.
Ploplis
Victoria A
VA
W. M. Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556, USA.
Castellino
Francis J
FJ
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000097:blood; D001327:Autoimmune Diseases / Q000097:blood; D001798:Blood Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D002465:Cell Movement; D004730:Endothelium, Vascular / Q000293:injuries / Q000473:pathology; D005342:Fibrinolysis / Q000235:genetics* / Q000502:physiology; D018390:Gene Targeting; D005921:Glomerulonephritis / Q000097:blood; D007239:Infections / Q000097:blood; D007249:Inflammation / Q000097:blood; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000097:blood; D010641:Phenotype; D011658:Pulmonary Fibrosis / Q000097:blood; D014945:Wound Healing
D001798:Blood Proteins