Aging, the brain and human prion disease.
Human prion diseases (PrD) preferentially manifest in the elderly. Their neuropathology may coexist with tau immunoreactive neuropil threads, neurofibrillary tangles, and beta-amyloid senile plaques, most likely representing an age-related change rather than a pathogenic link with Alzheimer's disease. Cerebrovascular disease with brain infarction, another malady preferring the elderly, is useful to prove the origin of PrD-associated prion protein deposition exclusively from neurons.
Kovács
Gábor G
GG
Institute of Neurology, University of Vienna, Austrian Reference Center of Human Prion Diseases, AKH 4J, P.O. Box 48, Wahringer Gurtel 18-20, 1097, Vienna, Austria.
Budka
Herbert
H
D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000473:pathology; D001921:Brain / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology; D006801:Humans; D011328:Prions / Q000032:analysis
D011328:Prions