title: Microwave parallel library generation: comparison of a conventional- and microwave-generated substituted 4(5)-sulfanyl-1H-imidazole library.
abstract: A methodology for the microwave parallel synthesis of libraries is described. The procedure involves the use of an array of expandable reaction vessels, which can accommodate pressure buildup within the vessel due to heating without loss of volatile solvents or reagents. A demonstration 24-membered library of substituted 4(5)-sulfanyl-1H-imidazoles was generated by both conventional and microwave procedures, achieving a reduction from 12 h to 16 min in library generation time for the microwave approach.
authors.affiliation: Conway Institute of Biomolecular and Biomedical Research, Department of Chemistry, University College Dublin, Dublin 4, Ireland.
authors.forename: Claire M
authors.initials: CM
authors.lastname: Coleman
authors.forename: J M D
authors.initials: JM
authors.lastname: MacElroy
authors.forename: John F
authors.initials: JF
authors.lastname: Gallagher
authors.forename: Donal F
authors.initials: DF
authors.lastname: O'Shea
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004867:Equipment Design; D006358:Hot Temperature; D007093:Imidazoles / Q000138:chemical synthesis*; D008872:Microwaves; D011312:Pressure; D013440:Sulfides / Q000138:chemical synthesis*; D013997:Time Factors
chemical_list: D007093:Imidazoles; D013440:Sulfides