title: [Perianal precancerous conditions (Bowen disease, Paget disease, Carcinoma in situ, Buschke-Lowenstein tumor)].
abstract: Perianal premalignant lesions are rare. Any suspicious perianal lesion or any perianal exanthema, that does not heal by non-surgical treatment has to be biopsied for histology. Many premalignant lesions are diagnosed as an incidental finding after anorectal surgery: any anorectal specimen must be examined by the pathologist. Leukoplakia is a facultative premalignant condition. High-grade anal intraepithelial neoplasia (AIN) is an in situ squamous cell carcinoma, associated with papillomavirus infection. Bowen's disease and Bowenoid papulosis are clinical variations of high-grade AIN. Buschke-Löwenstein tumour (giant condyloma) is a locally destructive tumour, that does not infiltrate or cause metastases. Paget's disease is a premalignant lesion like AIN, associated with other malignancies.
authors.affiliation: Proktologische Praxis und Abteilung Chirurgische Proktologie, Park-Klinik, Goethestrasse 11, 24116 Kiel.
authors.forename: J
authors.initials: J
authors.lastname: Jongen
authors.forename: M
authors.initials: M
authors.lastname: Reh
authors.forename: J U
authors.initials: JU
authors.lastname: Bock
authors.forename: G
authors.initials: G
authors.lastname: Rabenhorst
mesh_terms: D001003:Anal Canal / Q000473:pathology / Q000601:surgery; D001005:Anus Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D001706:Biopsy; D001913:Bowen's Disease / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D003218:Condylomata Acuminata / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D006801:Humans; D007971:Leukoplakia / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D010145:Paget Disease, Extramammary / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011379:Prognosis