title: 2-amino-substituted 1-sulfinylferrocenes as chiral ligands in the addition of diethylzinc to aromatic aldehydes.
abstract: A simple and modulable access to a structural variety of enantiopure amino-substituted ferrocenyl sulfoxides and their use as chiral catalysts in the asymmetric addition of diethylzinc to aromatic aldehydes is described. Moderate to high enantioselectivities (up to 96% ee) were obtained in the case of the arylsulfonamide ligands (R(Fc), R(S))-4h and (R(Fc), R(S))-4i. It has been demonstrated that the planar chirality of the ferrocene unit is the decisive chiral element involved in the reaction.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
authors.forename: Julián
authors.initials: J
authors.lastname: Priego
authors.forename: Olga García
authors.initials: OG
authors.lastname: Mancheño
authors.forename: Silvia
authors.initials: S
authors.lastname: Cabrera
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Carretero