[Interference of hydroxocobalamine treatment on commun biochemical determinations].
Hydroxocobalamin, antidote of the cyanide poisoning, is a red and water soluble pigment, which colors biological mediums. The interferences caused by this molecule are studied for plasma pools overloaded with hydroxocobalamin for concentrations from 0 to 1,125 mg.L-1. The results of 16 biochemical parameters on Vitros  750 XRC (Ortho-clinical Diagnostics) and of 23 biochemical parameters on Cobas  Integra 700 (Roche Diagnostics) are examined. With this analytical system, unconjugated and conjugated bilirubin, creatinin, and CK results are changed as soon as plasma concentration of hydroxocobalamin reachs 124 mg.L-1. For the Vitros  750 XRC, ASAT, iron, creatinin, phosphorus are more sensitive to this interference. But, other results are changed for the two analytical systems for superior hydroxocobalamin concentrations.
Vest
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Service de biochimie, toxicologie et pharmacologie cliniques, Hôpital d'instruction des armées Percy, 101, avenue Henri-Barbusse, 92141 Clamart cedex.
Renaudeau
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Tellal
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Ragot
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Renard
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D001774:Blood Chemical Analysis; D006801:Humans; D006879:Hydroxocobalamin / Q000737:chemistry / Q000494:pharmacology*
D006879:Hydroxocobalamin