Enterostatin increases extracellular serotonin and dopamine in the lateral hypothalamic area in rats measured by in vivo microdialysis.
The effect of enterostatin injection into the rat lateral hypothalamic area (LHA) on serotonin and dopamine releases in extracellular space was investigated by in vivo microdialysis technique. The primary focus being to understand whether a small amount of enterostatin crossing the blood-brain barrier correlates with activity changes in serotonergic and dopaminergic nervous systems or not. We found a significant elevation in serotonin release in the LHA. The enterostatin perfusion also induced a smaller but significant increase in dopamine level than serotonin one. This result suggests that enterostatin plays some sort of role in the control of feeding of fat through the control serotonergic and dopaminergic satiety mechanism.
Koizumi
Miwako
M
Laboratory of Nutrition, Department of Human Life Science, Graduate School of Human Life Science, Showa Women's University, 1-7 Taishido, Setagaya-ku, Tokyo 154-8533, Japan.
Kimura
Shuichi
S
D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects / Q000502:physiology; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000502:physiology; D003089:Colipases / Q000493:pharmacokinetics*; D004041:Dietary Fats / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004792:Enzyme Precursors; D005110:Extracellular Space / Q000187:drug effects* / Q000378:metabolism; D007026:Hypothalamic Area, Lateral / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D011498:Protein Precursors / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D003089:Colipases; D004041:Dietary Fats; D004792:Enzyme Precursors; D011498:Protein Precursors; D012701:Serotonin; C037107:procolipase; D004298:Dopamine