Use of affinity capillary electrophoresis for characterizing pharmaceutical colloidal vehicle systems thermodynamically.
This review offers a detailed discussion of the interaction between pharmaceutical compounds and vehicles using the affinity capillary electrophoresis and the microemulsion electrokinetic chromatography. Partition coefficients of drugs were calculated between a micelle and an aqueous phases from the measurement of the migration time, provided the critical micelle concentration and the phase ratio are known. Thermodynamic quantities such as enthalpy and entropy changes of micellar solubilization were calculated from the temperature dependence of the partition coefficients. Partial specific volumes were measured using dynamic light scattering. The logarithm of the partition coefficients and the capacity factor in the micellar system were correlated with the logarithm of the n-octanol/water partition coefficients.
Reinhard
N
N
Institute of Pharmaceutics and Biopharmaceutics, Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle/S., Germany.
Mrestani
Y
Y
D003102:Colloids; D019075:Electrophoresis, Capillary; D004655:Emulsions; D008823:Micelles; D014677:Pharmaceutical Vehicles; D012995:Solubility; D013816:Thermodynamics
D003102:Colloids; D004655:Emulsions; D008823:Micelles; D014677:Pharmaceutical Vehicles