Checkpoints: how to flag up double-strand breaks.
How checkpoint pathways recognise double-strand breaks has long been a mystery. Recent studies have found that two distinct checkpoint protein complexes associate independently with chromatin at the sites of DNA damage. Why do two distinct mechanisms recognise strand lesions, and what does this tell us about the checkpoint pathways?
Caspari
Thomas
T
Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RR, UK.
Carr
Antony M
AM
D018797:Cell Cycle Proteins / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D045643:DNA Repair Enzymes; D004268:DNA-Binding Proteins; D004720:Endonucleases / Q000378:metabolism; D005090:Exodeoxyribonucleases; D046911:Macromolecular Substances; D010750:Phosphoproteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins
D018797:Cell Cycle Proteins; D002843:Chromatin; D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D010750:Phosphoproteins; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; C106332:hus1 protein, S pombe; C069930:rad9 protein; D004247:DNA; D004720:Endonucleases; D005090:Exodeoxyribonucleases; C069266:RAD1 protein, S cerevisiae; C429526:three prime repair exonuclease 1; D045643:DNA Repair Enzymes