title: Aquagenic syringeal acrokeratoderma (transient reactive papulotranslucent acrokeratoderma).
abstract: In 1996, English and McCollough described an unusual entity in 2 sisters characterized by a transient and recurrent keratoderma exclusively on the palms after water exposure. The condition developed 3-5 min after exposure to water and resolved within a short time after drying. This finding was associated with a tightening sensation. Yan et al. coined the term 'aquagenic palmoplantar keratoderma', and the designation 'aquagenic syringeal acrokeratoderma' was suggested by MacCormack et al. Until now, a total of 8 cases have been reported. We documented 2 new cases with acquired aquagenic syringeal acrokeratoderma. A 25-year-old female had observed within the last 3 months a burning sensation on the palms after some minutes of water contact. Physical examination revealed a perfectly normal skin on the palms. Three minutes after water immersion of 20 degrees C, a whitish discoloration appeared on the palms and a thickening of the palmar skin was visible. In addition, the eccrine pores were much more prominent. Few minutes after drying the skin, the situation returned to a normal state. The second patient, a 33-year-old female noticed a painful whitish discoloration of the skin on the palms after a short period of water immersion. Sometimes the white skin could be peeled off. In the last year, hyperhidrosis developed, and a more reddish aspect of the palms appeared. In our office after rinsing the hands with water at room temperature, a whitish discoloration in the center of the palms appeared which was associated with a painful sensation. After drying, the whitish lesions disappeared almost completely within 30 min. Aquagenic palmar keratoderma describes an acquired and transient condition which occurs after brief exposure to water and disappears after drying within minutes to an hour. Only rarely may a slight hyperkeratosis remain for a longer time. The possible pathophysiology and treatment options are discussed.
authors.affiliation: Department of Dermatology, Kantonsspital Aarau, Switzerland. pitin@hin.ch
authors.forename: P H
authors.initials: PH
authors.lastname: Itin
authors.forename: S
authors.initials: S
authors.lastname: Lautenschlager
mesh_terms: D000169:Acrodermatitis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D000328:Adult; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D011379:Prognosis; D017444:Skin Diseases, Papulosquamous / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D014867:Water / Q000009:adverse effects*
chemical_list: D014867:Water