Reaction equilibrium of penicillin G with amberlite LA-2 in a nonpolar organic solvent.
Studies have been made of the reactive extraction of penicillin G by Amberlite LA-2, a secondary amine, dissolved in kerosene. On the basis of the previous works about extraction equilibria of monocarboxylic acids by some secondary amines in low polar organic solvents, four equilibrium models were suggested to describe the reaction equilibrium of penicillin G in the liquid-liquid extraction system. The calculated results from the models were compared with the experimental data of 96 runs, and only two equilibrium models seemed to be probable. Ultimately, the most reasonable extraction equilibrium model was chosen through spectroscopic studies on organic solutions obtained by five specific extraction equilibrium experiments.
Lee
Sang Cheol
SC
School of Material Science & Chemical Engineering, Kunsan National University, Miryong Dong, Kunsan, Chonbuk 573-701, South Korea. lee40f@kunsan.ac.kr
Ahn
Byoung Sung
BS
Kim
Jin Gu
JG
D000588:Amines / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry / Q000302:isolation & purification; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008956:Models, Chemical; D010400:Penicillin G / Q000737:chemistry* / Q000302:isolation & purification*; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013055:Spectrophotometry, Infrared
D000588:Amines; D002264:Carboxylic Acids; D012997:Solvents; C016214:Amberlite LA-2; D010400:Penicillin G