title: New indene-derivatives with anti-proliferative properties.
abstract: Metabolites of the non-steroidal anti-inflammatory drug Sulindac inhibit cell proliferation by affecting several intracellular signaling pathways including the tumorigenic Ras/Raf/MAPK pathway. Here, we report the synthesis of eight new indene derivatives derived from the Sulindac structure, and present data on their anti-proliferative properties and their effects on the p21ras protein.
authors.affiliation: Max-Planck-Institut fur Molekulare Physiologie, Dortmund, Germany.
authors.forename: Ioanna-Maria
authors.initials: IM
authors.lastname: Karaguni
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Glüsenkamp
authors.forename: Anette
authors.initials: A
authors.lastname: Langerak
authors.forename: Christoph
authors.initials: C
authors.lastname: Geisen
authors.forename: Volker
authors.initials: V
authors.lastname: Ullrich
authors.forename: Günther
authors.initials: G
authors.lastname: Winde
authors.forename: Tarik
authors.initials: T
authors.lastname: Möröy
authors.forename: Oliver
authors.initials: O
authors.lastname: Müller
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D004285:Dogs; D006801:Humans; D007192:Indenes / Q000138:chemical synthesis / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D051379:Mice; D015689:Oncogene Protein p21(ras) / Q000037:antagonists & inhibitors / Q000187:drug effects; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects; D013467:Sulindac / Q000031:analogs & derivatives*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D016861:Cyclooxygenase Inhibitors; D007192:Indenes; D013467:Sulindac; D011451:Prostaglandin-Endoperoxide Synthases; D015689:Oncogene Protein p21(ras)