Release from or through a wax matrix system. II. Basic properties of release from or through the wax matrix layer.
In order to examine basic properties of release from and through wax matrix layer, reservoir device matrix tablet was prepared from a physical mixture of hydrogenated caster oil and drug that was the same one in the reservoir. Release process could be divided into two stages. The first stage was the formation process of water channel by dissolving the drug in the wax matrix layer, and dissolved drug was released from the matrix layer following the square-root-of-time law equation. Hence, the drug penetration coefficient and tortuosity in the matrix layer were estimated. The second stage was the zero order release process of drug in the reservoir through the wax matrix layer. The release rate constant was calculated from the slope of line. Hence, the drug permeability coefficient and tortuosity were estimated. Fundamentally, tortuosity can not be expressed by some meaningful factors, and is obtained as an experimental result. By preparing wax matrix system from a physical mixture other than melted granule method, it was suggested that the matrix structure was uniform three-dimensionally. As a result, tortuosity could be expressed by a function of porosity, because unrecognized factors such as the surface coverage and thickness of melted wax on the soluble component should not be involved.
Yonezawa
Yorinobu
Y
Faculty of Pharmacy, Meijo University, Nagoya, Japan. yzw@ccmfs.meijo-u.ac.jp
Ishida
Sumio
S
Suzuki
Shinobu
S
Sunada
Hisakazu
H
D016503:Drug Delivery Systems; D012995:Solubility; D013607:Tablets; D014885:Waxes
D013607:Tablets; D014885:Waxes