title: Combined effect of glutathione S-transferase M1 and T1 genotypes on bladder cancer risk.
abstract: To evaluate the association between genetic polymorphism of GSTM1, GSTT1 and development of bladder cancer, a hospital-based case-control study was conducted in South Korea. The study population consisted of 232 histologically confirmed male bladder cancer cases and 165 male controls enrolled from urology departments with no previous history of cancer or systemic diseases in Seoul during 1997-1999. The GSTM1 null genotype was significantly associated with bladder cancer (OR: 1.6, 95% CI: 1.0-2.4), whereas the association observed for GSTT1 null genotype did not reach statistical significance (OR: 1.3, 95% CI: 0.9-2.0). There was a statistically significant multiple interaction between GSTM1 and GSTT1 genotype for risk of bladder cancer (P=0.04); the risk associated with the concurrent lack of both of the genes (OR: 2.2, 95% CI: 1.2-4.3) was greater than the product of risk in men with GSTM1 null/GSTT1 present (OR: 1.3, 95% CI: 0.7-2.5) or GSTM1 present/GSTT1 null (OR: 1.1, 95% CI: 0.6-2.2) genotype combinations.
authors.affiliation: Department of Internal Medicine, Hallym University College of Medicine, ChoonChun, South Korea.
authors.forename: Seung Joon
authors.initials: SJ
authors.lastname: Lee
authors.forename: Soo Hun
authors.initials: SH
authors.lastname: Cho
authors.forename: Sue Kyung
authors.initials: SK
authors.lastname: Park
authors.forename: Soo Woong
authors.initials: SW
authors.lastname: Kim
authors.forename: Moon Soo
authors.initials: MS
authors.lastname: Park
authors.forename: Han Yong
authors.initials: HY
authors.lastname: Choi
authors.forename: Ji Yeob
authors.initials: JY
authors.lastname: Choi
authors.forename: Sang Yoon
authors.initials: SY
authors.lastname: Lee
authors.forename: Hyoung June
authors.initials: HJ
authors.lastname: Im
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Kim
authors.forename: Ki Jung
authors.initials: KJ
authors.lastname: Yoon
authors.forename: Hwang
authors.initials: H
authors.lastname: Choi
authors.forename: Sang Goo
authors.initials: SG
authors.lastname: Shin
authors.forename: Tae Won
authors.initials: TW
authors.lastname: Park
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Ari
authors.initials: A
authors.lastname: Hirvonen
authors.forename: Daehee
authors.initials: D
authors.lastname: Kang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000235:genetics*
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1