An investigation of the antiinflammatory effects of an extract from Cladonia rangiformis HOFFM.
In this study, the antiinflammatory effects of 50, 100 and 200 mg/kg doses of extract obtained from Cladonia rangiformis, so-called C-1, were investigated. The effects of C-1 on the acute phase of inflammation were studied in formaldehyde-induced edema. A cotton-pellet granuloma test was used to investigate the effects of C-1 on chronic inflammation. The antiedema potency of C-1 was compared with indomethacin. C-1 at the doses mentioned above showed 33.8% (p<0.005), 36.1% (p<0.005), 43.1% (p<0.001) inhibition, respectively. The corresponding antiinflammatory effect for indomethacin was determined as 72% (p<0.001). 200 mg/kg C-1 and 10 mg/kg indomethacin decreased the formation of granuloma tissue induced by cotton-pellet method at a rate of 57.3% (p<0.005) and 52.1% (p<0.005), respectively. It was seen that C-1 was more effective on chronic inflammation than on acute inflammation.
Süleyman
Halis
H
Atatürk University, Faculty of Medicine, Department of Pharmacology, Erzurum, Turkey. suleyman@atauni.edu.tr
Yildirim
Derya
D
Aslan
Ali
A
Göçer
Fatma
F
Gepdiremen
Akçahan
A
Güvenalp
Zuhal
Z
D000208:Acute Disease; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002908:Chronic Disease; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D005557:Formaldehyde; D003368:Gossypium; D006099:Granuloma / Q000188:drug therapy / Q000473:pathology; D007213:Indomethacin / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D008011:Lichens / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D005557:Formaldehyde; D007213:Indomethacin