Screening of antibiotic resistant inhibitors from local plant materials against two different strains of Staphylococcus aureus.
The inhibitory effects of methanolic extracts of 19 Jordanian plants and their combinations with seven antibiotics, on the resistance of Staphylococcus aureus were checked. Methicillin resistant S. aureus (MRSA), which was isolated from patient and a standard strain of S. aureus were used. Our results showed that there are variations in the effect of some combinations used on the resistant and the standard strains probably due to structural changes. Common results between the two strains showed that combinations of gentamicin and chloramphenicol could be improved by the use of plant materials, whereas nalidixic acid activity cannot be improved when combined with plant materials.
Darwish
Rula M
RM
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Jordan, Amman, Jordan. rulad@ju.edu.jo
Aburjai
T
T
Al-Khalil
S
S
Mahafzah
A
A
D000900:Anti-Bacterial Agents; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data; D024881:Drug Resistance, Bacterial / Q000502:physiology*; D004359:Drug Therapy, Combination / Q000494:pharmacology; D006801:Humans; D016106:Methicillin Resistance; D010936:Plant Extracts / Q000494:pharmacology*; D018514:Plant Structures; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D010936:Plant Extracts