title: Chromosomal congenital anomalies and residence near hazardous waste landfill sites.
abstract: Previous findings of the EUROHAZCON study showed a 33% increase in risk of non-chromosomal anomalies near hazardous waste landfill sites. Here, we studied 245 cases of chromosomal anomalies and 2412 controls who lived near 23 such sites in Europe. After adjustment for confounding by maternal age and socioeconomic status, we noted a higher risk of chromosomal anomalies in people who lived close to sites (0-3 km) than in those who lived further away (3-7 km; odds ratio 1.41, 95% CI 1.00-1.99). Our results suggest an increase in risk of chromosomal anomalies similar to that found for non-chromosomal anomalies.
authors.affiliation: EUROCAT Central Registry, Environmental Epidemiology Unit, Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK. m.vrijheid@lshtm.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Vrijheid
authors.forename: H
authors.initials: H
authors.lastname: Dolk
authors.forename: B
authors.initials: B
authors.lastname: Armstrong
authors.forename: L
authors.initials: L
authors.lastname: Abramsky
authors.forename: F
authors.initials: F
authors.lastname: Bianchi
authors.forename: I
authors.initials: I
authors.lastname: Fazarinc
authors.forename: E
authors.initials: E
authors.lastname: Garne
authors.forename: R
authors.initials: R
authors.lastname: Ide
authors.forename: V
authors.initials: V
authors.lastname: Nelen
authors.forename: E
authors.initials: E
authors.lastname: Robert
authors.forename: J E S
authors.initials: JE
authors.lastname: Scott
authors.forename: D
authors.initials: D
authors.lastname: Stone
authors.forename: R
authors.initials: R
authors.lastname: Tenconi
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology / Q000235:genetics*; D002869:Chromosome Aberrations / Q000139:chemically induced* / Q000196:embryology / Q000706:statistics & numerical data; D004314:Down Syndrome / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics; D005060:Europe / Q000453:epidemiology; D005260:Female; D006256:Hazardous Waste / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016017:Odds Ratio; D011247:Pregnancy; D018570:Risk Assessment
chemical_list: D006256:Hazardous Waste