Hemostatic factors as predictors of coronary events and total mortality: The FINRISK '92 Hemostasis Study.
The role of hemostatic factors as predictors of coronary heart disease (CHD) and total mortality is poorly understood. Therefore, we carried out a prospective cohort study in Finland. In 1992, a random population sample of 2378 men and women aged 45 to 64 years was investigated and then followed up until December 31, 1998. During the follow-up, 133 CHD events were observed; 73 were among participants free of CHD at baseline. The total number of deaths was 124. After adjustment for traditional risk factors and prevalent CHD at baseline and correction for regression dilution bias, a 1-SD increase in plasminogen was associated with a 1.41-fold (95% CI 1.09 to 1.81) increase in CHD risk. The predictive power of plasminogen depended significantly on the level of total cholesterol being stronger for persons with high cholesterol. A 1-SD increase in fibrinogen was associated with a 1.23-fold (95% CI 1.05 to 1.44) increase in all-cause mortality, but its association with CHD events did not reach statistical significance. Factor VII antigen or coagulant activity or lipoprotein(a) were not independent predictors of CHD risk. These findings support the role of plasminogen as a risk factor for CHD events.
Salomaa
Veikko
V
Department of Epidemiology and Health Promotion, KTL-National Public Health Institute, Helsinki, FInland. veikko.salomaa@ktl.fi
Rasi
Vesa
V
Kulathinal
Sangita
S
Vahtera
Elina
E
Jauhiainen
Matti
M
Ehnholm
Christian
C
Pekkanen
Juha
J
D000941:Antigens / Q000097:blood; D001685:Biological Factors / Q000097:blood; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D003327:Coronary Disease / Q000097:blood* / Q000401:mortality*; D005167:Factor VII; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D005500:Follow-Up Studies; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate
D000941:Antigens; D001685:Biological Factors; D017270:Lipoprotein(a); C042580:factor VII clotting antigen; D005167:Factor VII; D005340:Fibrinogen; D010958:Plasminogen; D002784:Cholesterol