title: [How can the effectiveness of multimodality therapy concepts be evaluated? From the viewpoint of the pathologist].
abstract: Prognostically relevant histopathological grading of tumor regression (grades I-III) is possible, although laborious. Morphological changes after chemotherapy indicate a specific response to treatment with central fibrosis and residual tumor islands in the periphery. Prognostic factors, such as TNM categories, UICC-R status, tumor size, and lymphangiosis, which are not intrinsic part of regression grading still correlate with patient survival.
authors.affiliation: Institut für Pathologie, Technische Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 München.
authors.forename: K
authors.initials: K
authors.lastname: Becker
authors.forename: U
authors.initials: U
authors.lastname: Fink
authors.forename: K
authors.initials: K
authors.lastname: Ott
authors.forename: R
authors.initials: R
authors.lastname: Busch
authors.forename: J R
authors.initials: JR
authors.lastname: Siewert
authors.forename: H
authors.initials: H
authors.lastname: Höfler
mesh_terms: D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D006801:Humans; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000401:mortality / Q000473:pathology / Q000628:therapy; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate