title: Quality of life in functional dyspepsia.
abstract: Our purpose was to assess the quality of life of functional dyspepsia patients using the SF-36 generic scale and the Gastrointestinal Symptoms Rating Scale (GSRS). In all, 328 dyspeptic patients were included in a multicenter, prospective, observational study. Both scales were filled out at baseline and one and three months after a prokinetic agent was given as a single-drug therapy. A total of 250 patients completed the study. An improvement in all SF-36 dimensions was observed, although the final scores were lower than the population reference values. Physical role (27% change), emotional role (20%), and physical pain (16%) dimensions showed the greater change. The GSRS total and domain scores also showed significant decreases. The best predictors of quality of life improvement were certain basal symptoms, drug compliance, and the absence of idiopathic dyspepsia. In conclusion, both the generic and the specific scales provide useful and sensitive measures of quality of life in functional dyspepsia patients on single-drug treatment.
authors.affiliation: Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Universidad Autónoma de Barcelona, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Monés
authors.forename: Ana
authors.initials: A
authors.lastname: Adan
authors.forename: José L
authors.initials: JL
authors.lastname: Segú
authors.forename: Juan S
authors.initials: JS
authors.lastname: López
authors.forename: Maite
authors.initials: M
authors.lastname: Artés
authors.forename: Tina
authors.initials: T
authors.lastname: Guerrero
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004415:Dyspepsia / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011446:Prospective Studies; D011788:Quality of Life