title: A 16-year experience in performing hepatic resection in 303 patients with hepatocellular carcinoma: 1985-2000.
abstract: BACKGROUND
  Hepatic resection is an accepted therapeutic modality for hepatocellular carcinoma (HCC). Over the past 2 decades, liver surgery has evolved to a refined and deliberate operation. In the present study surgical results are analyzed with an aim toward further improving the treatment of HCC.
  
  
  METHODS
  We studied 303 patients with HCC who underwent a hepatic resection at 2 university hospitals from 1985 through 2000. Living-related liver transplantation was a procedure of choice in 1 patient with early staged HCC. Fifty-five percent of the patients had associated cirrhosis. Before the operation, the liver function was mainly evaluated with the indocyanine green retention test.
  
  
  RESULTS
  The mortality rate within 30 days after the operation was 1.6%. One-, 3-, 5-, 10-, and 15-year cumulative survival rates were 84%, 67%, 51%, 20%, and 11%, respectively. The tumor stage I and II groups showed superior survival rates to those of the tumor stage III and IV groups, respectively, and the difference was statistically significant. The disease-free survival curves, however, showed the rate to be 27% at 5 years and 11% at 10 years.
  
  
  CONCLUSIONS
  Although the surgical results have greatly improved in the treatment of HCC, the recurrence rate is still high. In carefully screened patients with poor liver function and small HCC, liver transplantation enhances the possibility of cure.
authors.affiliation: Department of Surgery II, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanematsu
authors.forename: Junichiro
authors.initials: J
authors.lastname: Furui
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yanaga
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Okudaira
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Shimada
authors.forename: Ken
authors.initials: K
authors.lastname: Shirabe
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D004396:Coloring Agents; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D007208:Indocyanine Green; D008113:Liver Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green