Synthesis of novel polyphenols consisted of ferulic and gallic acids, and their inhibitory effects on phorbol ester-induced Epstein-Barr virus activation and superoxide generation.
We prepared novel polyphenols which were esters composed of two naturally occurring products, ferulic and gallic acids, and investigated their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus (EBV) activation and superoxide (O2-) generation. Most of these compounds exhibited significant EBV activation suppression at a concentration of 20 microM and in particular, the ester 5f having 2-methyl-1-butyl group showed high activity. The suppressive effects on O2- generation were also observed in most of the esters.
Nomura
Eisaku
E
Industrial Technology Center of Wakayama Prefecture, 60 Ogura, 649-6261, Wakayama, Japan. nomura@wakayamakg.go.jp
Hosoda
Asao
A
Morishita
Hideko
H
Murakami
Akira
A
Koshimizu
Koichi
K
Ohigashi
Hajime
H
Taniguchi
Hisaji
H
D003373:Coumaric Acids / Q000737:chemistry; D005419:Flavonoids; D005707:Gallic Acid / Q000737:chemistry; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D010636:Phenols / Q000138:chemical synthesis / Q000494:pharmacology*; D010703:Phorbol Esters / Q000494:pharmacology; D011108:Polymers / Q000138:chemical synthesis / Q000494:pharmacology*; D059808:Polyphenols; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D014775:Virus Activation / Q000187:drug effects*
D003373:Coumaric Acids; D005419:Flavonoids; D010636:Phenols; D010703:Phorbol Esters; D011108:Polymers; D059808:Polyphenols; D013481:Superoxides; D005707:Gallic Acid; C004999:ferulic acid