[Expression of T cell factor 4 in renal cell carcinoma].
OBJECTIVE
To investigate of the transduction of Wnt/Frizzled pathway in nuclei and the function of TCF4 (T Cell Factor) in renal cell carcinoma.


METHODS
TCF4 mRNA are tested through RT-PCR and Northern Blot in renal cancer tissue and renal cancer cell strain (GRC-I).


RESULTS
It has been certificated that TCF4 are expressed in renal cell carcinoma, at the same time, there are some different splice of TCF4 in renal cancer. A new 300bp mutant gene are found.


CONCLUSIONS
TCF4, an important molecular of Wnt/Frizzled pathway, takes part in the formation and progression of renal cell carcinoma, different splice of TCF4 is one of the mechanism.
Lin
G
G
Department of Urology, First Hospital, Beijing Medical University, Beijing 100034, China.
Zang
T
T
Zhang
Z
Z
Xing
D
D
Guo
Y
Y
D015152:Blotting, Northern; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D051820:TCF Transcription Factors; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors / Q000235:genetics*; D014407:Tumor Cells, Cultured
D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors