title: One-pot preparation of chiral beta-amino esters by rhodium-catalyzed three-components coupling reaction.
abstract: Chiral beta-amino esters are synthesized in one-pot from three components, amines, aldehydes, and ethyl bromoacetate, under the rhodium-catalyzed Reformatsky-type reaction condition, where complete diastereoselection is achieved in the nucleophilic addition step of ethyl bromoacetate to the imines prepared in
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. honda@hoshi.ac.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Honda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Wakabayashi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kanai
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D012238:Rhodium / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D012238:Rhodium