title: Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses.
abstract: In this study, we compared the proliferation and differentiation of Ag-specific CD4 and CD8 T cells following Listeria infection. Our results show that CD4 T cells responding to infection divide a limited number of times, with progeny exhibiting proliferative arrest in early divisions. Even with increased infectious doses, CD4 T cells display this restricted proliferative pattern and are not driven to undergo extensive clonal expansion. This is in striking contrast to CD8 T cells, which undergo extensive proliferation in response to infection. These differences are also evident when CD4 and CD8 T cells receive uniform anti-CD3 stimulation in vitro. Together, these results suggest that CD4 and CD8 T cells are programmed to undergo limited and extensive proliferation, respectively, to suit their function as regulator and effector cells.
authors.affiliation: Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Foulds
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Zenewicz
authors.forename: Devon J
authors.initials: DJ
authors.lastname: Shedlock
authors.forename: Jiu
authors.initials: J
authors.lastname: Jiang
authors.forename: Amy E
authors.initials: AE
authors.lastname: Troy
authors.forename: Hao
authors.initials: H
authors.lastname: Shen
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D005434:Flow Cytometry; D007700:Kinetics; D008088:Listeriosis / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010047:Ovalbumin / Q000235:genetics / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology; D013154:Spleen / Q000276:immunology
chemical_list: D011994:Recombinant Proteins; D010047:Ovalbumin