title: Reappraisal of the serotonin 5-HT(1B) receptor gene in alcoholism: of mice and men.
abstract: Because pharmacological and genetic data supported the idea that serotonin receptors of the 5-HT(1B) type can play a modulatory role in alcohol consumption in both human and rodents, the 5-HT(1B) receptor gene is considered as a candidate gene for alcohol dependence. However, contradictory results have been reported as a positive association between alcohol dependence, and either the 861C or the 861G allele of the G861C polymorphism of the 5-HT(1B) receptor gene can be found in the literature. Further investigations in a population of 136 male alcoholics compared with 72 male control subjects demonstrated that none of these alleles was actually associated with alcohol dependence. In addition, in contrast with previous results of the literature, ethanol intake under free choice conditions (i.e., ethanol solution vs. water) was found to be similar in 5-HT(1B)-/- knock mice and paired wild-type controls. The 5-HT(1B) receptor gene may thus not be a key component in the genetic background underlying alcohol dependence in human and alcohol preference in rodents, although these results should be considered as preliminary according to the small size of our sample.
authors.affiliation: Hôpital Louis Mourier, Service de Psychiatrie, Colombes, France. philip.gorwood@lmr.ap-hop-paris.fr
authors.forename: Philip
authors.initials: P
authors.lastname: Gorwood
authors.forename: Franck
authors.initials: F
authors.lastname: Aissi
authors.forename: Philippe
authors.initials: P
authors.lastname: Batel
authors.forename: Jean
authors.initials: J
authors.lastname: Adès
authors.forename: Charles
authors.initials: C
authors.lastname: Cohen-Salmon
authors.forename: Michel
authors.initials: M
authors.lastname: Hamon
authors.forename: Claudette
authors.initials: C
authors.lastname: Boni
authors.forename: Laurence
authors.initials: L
authors.lastname: Lanfumey
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D005787:Gene Frequency / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin / Q000172:deficiency / Q000235:genetics*; D012701:Serotonin / Q000378:metabolism; D009435:Synaptic Transmission / Q000235:genetics
chemical_list: C470302:HTR1B protein, human; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin; D012701:Serotonin