title: Different types of aortic stenosis and simulation of their morphological-hydrodynamic interdependence--in vitro study with allografts and stenotic valve models.
abstract: Biological valves display a dependence of valve resistance and valve area on flow and a phase shift between systolic flow through the valves and pressure difference across the valves. The pressure-flow relations of stenosed valves raise questions about the "best measure of stenosis". There is a need for quantitative evaluation of the hydrodynamic performance of homografts and allografts. In the present paper, we report on in vitro studies of the hydrodynamic behavior of homografts from human donors, allografts from different animal species as well as three valve models. Valve model I was designed to simulate flow-dependence of valve area, valve model II was designed to simulate restricted valve opening independent of flow, and valve model III was designed to simulate a flow-dependent movement of valve root in flow direction. Among other aspects, the effect of increased viscosity of the test fluid on the pressure difference and the effects of water absorption by valve tissue on valve characteristics were investigated. The results of the present studies clearly indicate that any biological valve may be modelled as a serial connection of a model I type valve and a model II type valve. From the results, the dependence of the characteristic pressure-flow relationship of a valve on valve size and valve distensibility can be clearly seen and the clinical significance of the characteristic coefficients of the pressure-flow relationship of a valve can be elucidated. Further, it was shown that the characteristic phase shift between flow and pressure difference displayed by biological valves is due to their movable valve plane similar to that of valve model III.
authors.affiliation: Institute for Medical Physics and Biophysics, Humboldt University, University Hospital Charité, Berlin, Germany. manfred.pohl@charite.de
authors.forename: M
authors.initials: M
authors.lastname: Pohl
authors.forename: R
authors.initials: R
authors.lastname: Meyer
authors.forename: R
authors.initials: R
authors.lastname: Kühnel
authors.forename: N K
authors.initials: NK
authors.lastname: Talukder
authors.forename: M O
authors.initials: MO
authors.lastname: Wendt
mesh_terms: D000818:Animals; D001024:Aortic Valve Stenosis / Q000503:physiopathology / Q000601:surgery*; D001783:Blood Flow Velocity; D006350:Heart Valve Prosthesis; D008955:Models, Cardiovascular; D008961:Models, Structural; D011673:Pulsatile Flow / Q000502:physiology; D012680:Sensitivity and Specificity; D013552:Swine; D014184:Transplantation, Homologous