title: Sporotrichosis masquerading as pyoderma gangrenosum: case report and review of 19 cases of sporotrichosis.
abstract: We present the case of a 59-year-old woman who had large ulcerations on her right leg that were diagnosed initially as pyoderma gangrenosum and treated with three immunosuppressive agents (cyclosporin, prednisone and azathioprine) for 6 months. Results of a biopsy at 6 months showed numerous cigar-shaped bodies consistent with Sporothrix schenckii; identification was confirmed by tissue culture. A retrospective review was performed for all cases diagnosed as sporotrichosis from tissue culture or biopsy specimens at the Mayo Clinic. Nineteen cases were identified. The present case was the only one in which fungal organisms were visible on histological examination. The present case emphasizes the importance of making a definitive histological diagnosis in unusual ulcer cases or in suspected cases of pyoderma gangrenosum before the initiation of immunosuppressive therapy. The large number of cigar-shaped bodies in the tissue is a rare finding in sporothrix infection and has been reported in only two cases previously.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Byrd
authors.forename: R A
authors.initials: RA
authors.lastname: El-Azhary
authors.lastname: LE Gibson
authors.forename: G D
authors.initials: GD
authors.lastname: Roberts
mesh_terms: D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D003646:Debridement / Q000379:methods; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D017964:Itraconazole / Q000008:administration & dosage; D007866:Leg; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000175:diagnosis* / Q000473:pathology; D016038:Skin Transplantation / Q000379:methods; D013174:Sporotrichosis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D017964:Itraconazole