title: Ontogeny and the effect of aging on pancreatic polypeptide and peptide YY.
abstract: Pancreatic polypeptide (PP) and peptide YY (PYY) are related neuroendocrine peptides that are expressed in specialized cells. PP is found around the time of birth in different species. PYY in mice and rats has been extensively studied. PYY is the first peptide hormone to appear in both the pancreas and the colon and is initially expressed together with all other pancreatic islet and gut hormones. This suggests that there is a PYY-producing endocrine progenitor cell, at least in rodents. Whether the same is true for other species is unknown. In chickens, however, pancreatic insulin and glucagon cells appear before PYY. After birth, PYY levels in rats and humans reflect adaptation to enteral feeding. Whereas PYY cells increase with age in rodents, no such changes have been found in humans.
authors.affiliation: Section for Gastroenterology and Hepatology, Department of Medicine, Institution of Public Health and Clinical Medicine, University Hospital, Umeå, Sweden.
authors.forename: Olof
authors.initials: O
authors.lastname: Sandström
authors.forename: Magdy
authors.initials: M
authors.lastname: El-Salhy
mesh_terms: D000375:Aging; D000818:Animals; D002454:Cell Differentiation; D002645:Chickens; D003106:Colon / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010179:Pancreas / Q000378:metabolism; D010191:Pancreatic Polypeptide / Q000378:metabolism*; D019894:Peptide YY / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
chemical_list: D019894:Peptide YY; D010191:Pancreatic Polypeptide