Predicting novel protein folds by using FRAGFOLD.
The results of applying a fragment-based protein tertiary structure prediction method to the prediction of 8 CASP4 targets are described. The method is based on the assembly of supersecondary structural fragments taken from highly resolved protein structures using a simulated annealing algorithm. Despite the significant degree of success in this case, there is clearly much more developmental work required before predictions with the accuracy of a good homology model, or even a good fold recognition model, can be made with use of this kind of approach.
Jones
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DT
Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, United Kingdom.
D001430:Bacteriocins / Q000737:chemistry; D003198:Computer Simulation; D008958:Models, Molecular; D010446:Peptide Fragments / Q000737:chemistry; D011487:Protein Conformation; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D020539:Sequence Analysis, Protein; D012984:Software
D001430:Bacteriocins; D010446:Peptide Fragments; C440289:bacteriocin AS-48, Enterococcus faecalis