title: [Therapy relevant differences in beta blockers and ACE inhibitors. Innovation or plagiarism?].
abstract: As exemplified by the two classes of substance beta blockers and ACE inhibitors, the question is considered as to when new developments within a drug family can be termed innovations and when they must be seen purely as plagiarisms ("me-too" preparations). It is noted that in principle no innovations are to be expected from generics, since these substances are are not the subject of specific research. Although large-scale clinical studies in recent years have identified a new indication--cardiac insufficiency--for the beta blockers metoprolol, bisoprolol and carvedilol, this must not be considered an innovation in the sense of a new development. The translatability of the study results to uninvestigated substances is uncertain. In contrast to the beta blockers, the indications for the ACE inhibitors have long been known, but again, the new generic preparations that have come onto the market are not innovations.
authors.affiliation: Institut für experimentelle und klinische Pharmakologie und Toxikologie, Univ.-Klinikum Lübeck.
authors.forename: P
authors.initials: P
authors.lastname: Dominiak
authors.forename: A
authors.initials: A
authors.lastname: Dendorfer
authors.forename: W
authors.initials: W
authors.lastname: Raasch
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000075202:Contraindications; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy; D006801:Humans; D013810:Therapeutic Equivalency; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors