title: A facile one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones.
abstract: An efficient and practical one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones has been achieved from 1,2-diarylethanones and 2-bromoisobutyryl cyanide in the presence of excess base, by employing the 'hard soft acid base' principle. The reaction scope of 2-bromoisobutyryl cyanide could be expanded to prepare a variety of 2,2-dimethyl-3(2H)-furanone derivatives other than 4,5-diaryl-2,2-dimethyl-3(2H)-furanones.
authors.affiliation: Drug Discovery, Pacific Corporation R&D Center, 314-1 Bora-ri, Kiheung-eup, Yongin-si, 449-729, Kyounggi-do, South Korea.
authors.forename: Ki-Wha
authors.initials: KW
authors.lastname: Lee
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Choi
authors.forename: Yung Hyup
authors.initials: YH
authors.lastname: Joo
authors.forename: Jin Kwan
authors.initials: JK
authors.lastname: Kim
authors.forename: Song Seok
authors.initials: SS
authors.lastname: Shin
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Byun
authors.forename: Yeonjoon
authors.initials: Y
authors.lastname: Kim
authors.forename: Shin
authors.initials: S
authors.lastname: Chung
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis; D005663:Furans / Q000138:chemical synthesis*; D007659:Ketones
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D005663:Furans; D007659:Ketones