title: Pharmacokinetics of Pamidronate Disodium in Cancer Patients after a Single Intravenous Infusion of 30-, 60- or 90-mg Dose over 4 or 24 Hours.
abstract: The objective of this study was to determine the pharmacokinetics of pamidronate disodium in plasma and urine after a single intravenous infusion of the drug to cancer patients at risk for developing bone metastases. Thirty-six patients were randomized into six treatment groups to receive 30-, 60- or 90-mg doses of the drug by 4- or 24-h intravenous infusions. Plasma and urine samples were collected at intervals for up to 144 h after drug administration and were assayed for pamidronate disodium using validated reversed-phase HPLC methods. The percentage of the administered dose excreted in urine following a 4- or 24-h infusion of 30-, 60- or 90-mg pamidronate disodium ranged from 30% to 60% except for one individual who excreted 96% by this route of elimination. There was a linear relationship between amount of drug excreted in urine and dose. Curve fitting of ARE (amount of drug to be excreted in urine) data indicated that the disposition kinetics of the drug was consistent with a biexponential process with overall mean plus minus S.D. half-life values of 2.1 plus minus 1.8 and 26.9 plus minus 8.7 h for the alpha and beta phases, respectively. The results of this study showed that the drug exhibited dose proportionality in its pharmacokinetic behavior over the 30--90-mg range regardless of whether it was infused over a 4- or 24-h interval.
authors.affiliation: Ciba-Geigy Corporation, Ardsley, NY 10502, USA.
authors.forename: W. K.
authors.initials: WK
authors.lastname: Cheung
authors.forename: L.
authors.initials: L
authors.lastname: Brunner
authors.forename: S.
authors.initials: S
authors.lastname: Schoenfeld
authors.forename: R.
authors.initials: R
authors.lastname: Knight
authors.forename: J.
authors.initials: J
authors.lastname: Seaman
authors.forename: A.
authors.initials: A
authors.lastname: Brox
authors.forename: G.
authors.initials: G
authors.lastname: Batist
authors.forename: V.
authors.initials: V
authors.lastname: John
authors.forename: K.
authors.initials: K
authors.lastname: Chan