Influence of 2-substituent on the activity of imidazo[1,2-a] pyridine derivatives against human cytomegalovirus.
The synthesis of various 2-substituted imidazo[1,2-a]pyridine bearing a thioether side chain in position 3 was reported. The new compounds were characterized by 1H and 13C NMR spectra. A conformational study was obtained by X-ray crystallographic analysis for 2-biphen-4-ylimidazopyridine 7. The antiviral activity against human cytomegalovirus (HCMV) was investigated. It was strongly influenced by the nature of C-2 substituent.
Mavel
Sylvie
S
Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 31 Av. Monge, 37200, Tours, France.
Renou
Jean-Louis
JL
Galtier
Christophe
C
Allouchi
Hassan
H
Snoeck
Robert
R
Andrei
Graciella
G
De Clercq
Erik
E
Balzarini
Jan
J
Gueiffier
Alain
A
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D018360:Crystallography, X-Ray; D003587:Cytomegalovirus / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D011725:Pyridines; C001439:imidazo(1,2-a)pyridine