A lipid emulsion reduces mortality from clomipramine overdose in rats.
Tricyclic antidepressants are a common cause of self poisoning. Since these drugs are highly lipid soluble, we examined the interaction between imipramine and a lipid emulsion. Rats were given an iv dose of imipramine with either normal saline or a lipid emulsion as vehicle. The rats who received the lipid emulsion had a significantly lower mortality. The role of lipid emulsions poisoning therapy is reviewed.
Yoav
Goor
G
Department of Internal Medicine 6, Tel Aviv Sourasky Medical Centre, Israel.
Odelia
Goor
G
Shaltiel
Cabilil
C
Goor
Yoav
Y
Goor
Odelia
O
Cabili
Shaltiel
S
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000633:toxicity*; D002997:Clomipramine / Q000633:toxicity*; D062787:Drug Overdose / Q000188:drug therapy; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000929:Antidepressive Agents, Tricyclic; D005217:Fat Emulsions, Intravenous; D002997:Clomipramine