Multiple sclerosis-associated retrovirus (MSRV) in Sardinian MS patients.
Blood and CSF of Sardinian patients with MS and neurologic control subjects were tested for MS-associated retrovirus (MSRV). CSF detection in MS was 50% at clinical onset, increasing with temporal disease progression, and 40% in control subjects. In blood, MSRV was detected in all MS patients, in most patients with inflammatory neurologic diseases, and rarely in healthy blood donors. MSRV may represent a marker of neurologic diseases of inflammatory origin.
Dolei
A
A
Section of Experimental and Clinical Microbiology, Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, I-07100 Sassari. doleivir@ssmain.uniss.it
Serra
C
C
Mameli
G
G
Pugliatti
M
M
Sechi
G
G
Cirotto
M C
MC
Rosati
G
G
Sotgiu
S
S
D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000821:virology*; D015995:Prevalence; D012190:Retroviridae / Q000302:isolation & purification*; D012192:Retroviridae Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000453:epidemiology*