title: Intermediate term failure of pubovaginal slings using cadaveric fascia lata: a case series.
abstract: OBJECTIVE
  The pubovaginal sling procedure using autologous fascia has become the gold standard for treating intrinsic sphincter deficiency and stress urinary incontinence in women. A recent modification has been the use of cadaveric fascia as the sling material. We recently reported similar results for cadaveric fascia lata in 121 women and autologous fascia lata in 46 at a mean followup of 12 months. We have now identified 8 patients who experienced intermediate term failure at 4 to 13 months using cadaveric fascia lata.
  
  
  METHODS
  We retrospectively reviewed the records of 8 of 121 patients who received a pubovaginal sling using cadaveric fascia lata between February 1997 and June 1999 and had recurrent stress incontinence after 4 to 13 months. We reviewed the type of fascia, surgical technique, preoperative and postoperative urodynamics, surgical history and medical co-morbidities.
  
  
  RESULTS
  We identified 8 patients who underwent a pubovaginal sling using cadaveric fascia lata and had recurrent stress urinary incontinence at a mean of 6.5 months (range 4 to 13) after the procedure. Fresh frozen fascia from a local tissue bank was used and the surgical technique was identical in all cases. Postoperatively urodynamics confirmed recurrent intrinsic sphincter deficiency. Previous incontinence surgery had been done in 7 of the 8 patients. Patient co-morbidities included neurological disease, diabetes mellitus, previous pelvic irradiation and previous pelvic surgery.
  
  
  CONCLUSIONS
  We identified a higher than expected intermediate term failure rate using fresh frozen cadaveric fascia lata. This risk must be weighed against the advantages of decreased operative time and patient morbidity. Longer followup and larger numbers are necessary to determine how much of a problem exists and what patient characteristics are relevant when selecting cadaveric grafts.
authors.affiliation: Section of Urology and Renal Transplantation, Virginia Mason Medical Center, Seattle, Washington, USA.
authors.forename: Keith J
authors.initials: KJ
authors.lastname: O'Reilly
authors.forename: Fred E
authors.initials: FE
authors.lastname: Govier
mesh_terms: D002102:Cadaver; D005205:Fascia / Q000637:transplantation*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D012008:Recurrence; D012189:Retrospective Studies; D017211:Treatment Failure; D014550:Urinary Incontinence, Stress / Q000601:surgery*; D014563:Urodynamics