Anticonvulsant activity of reaction products of 5,5-diphenylhydantoin with substituted methylene bromides.
Some derivatives of 5,5-diphenylhydantoin (phenytoin) were synthesized by the alkylation of phenytoin with substituted methylene bromides. The hydantoins were evaluated for possible anticonvulsant activity in the maximal electroshock (MES)- and subcutaneous pentylenetetrazole (ScMet)-induced seizures and for neurotoxicity in the rotorod test in mice and rats.
Usifoh
C O
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Nigeria. usifoh@uniben.edu.ng
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D006842:Hydrocarbons, Brominated / Q000737:chemistry; D007274:Injections, Intraperitoneal; D051379:Mice; D010672:Phenytoin / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D012640:Seizures / Q000517:prevention & control
D000927:Anticonvulsants; D006842:Hydrocarbons, Brominated; D010672:Phenytoin; C027947:methylene bromide