Localization of a susceptibility gene for common forms of stroke to 5q12.
Stroke is one of the most complex diseases, with several subtypes, as well as secondary risk factors, such as hypertension, hyperlipidemia, and diabetes, which, in turn, have genetic and environmental risk factors of their own. Here, we report the results of a genomewide search for susceptibility genes for the common forms of stroke. We cross-matched a population-based list of patients with stroke in Iceland with an extensive computerized genealogy database clustering 476 patients with stroke within 179 extended pedigrees. Linkage to 5q12 was detected, and the LOD score at this locus meets the criteria for genomewide significance (multipoint allele-sharing LOD score of 4.40, P=3.9 x 10(-6)). A 20-cM region on 5q was physically and genetically mapped to obtain accurate marker order and intermarker distances. This locus on 5q12, which we have designated as "STRK1," does not correspond to known susceptibility loci for stroke or for its risk factors and represents the first mapping of a locus for common stroke.
Gretarsdottir
Solveig
S
deCODE Genetics, Reykjavik, Iceland.
Sveinbjörnsdottir
Sigurlaug
S
Jonsson
Hjörtur H
HH
Jakobsson
Finnbogi
F
Einarsdottir
Elisabet
E
Agnarsson
Uggi
U
Shkolny
Dana
D
Einarsson
Gisli
G
Gudjonsdottir
Herdis M
HM
Valdimarsson
Einar M
EM
Einarsson
Olafur B
OB
Thorgeirsson
Gudmundur
G
Hadzic
Radinka
R
Jonsdottir
Sif
S
Reynisdottir
Sigridur Th
ST
Bjarnadottir
Sigrun M
SM
Gudmundsdottir
Thorunn
T
Gudlaugsdottir
Gudrun J
GJ
Gill
Ramanjit
R
Lindpaintner
Klaus
K
Sainz
Jesus
J
Hannesson
Helgi H
HH
Sigurdsson
Gunnar Th
GT
Frigge
Michael L
ML
Kong
Augustine
A
Gudnason
Vilmundur
V
Stefansson
Kari
K
Gulcher
Jeffrey R
JR
D000483:Alleles; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000235:genetics; D006973:Hypertension / Q000150:complications / Q000235:genetics; D007055:Iceland; D008126:Lod Score; D008297:Male; D010375:Pedigree; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000235:genetics*
D005819:Genetic Markers