The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats.
The effects of a previous long-term administration of the mitochondrial toxin 3-nitropropionic acid were studied on an animal model of tardive dyskinesia, i.e., the frequency of spontaneous tongue protrusions in rats repeatedly treated with reserpine. 3-Nitropropionic acid (10 or 15 mg/kg i.p., every other day for 17 days) potentiated the increase in tongue-protrusion frequency induced by reserpine (1 mg/kg, s.c., every other day for 3 days) but did not modify reserpine-induced increase in immobility duration and decrease in locomotion frequency. These results support the notion that neurotoxic events are associated with the development of tardive dyskinesia.
Calvente
Patricia R V
PR
Departamento de Farmacologia, São Paulo, SP, Brazil.
Araujo
Carlos C S
CC
Bergamo
Marcelo
M
Abilio
Vanessa C
VC
D'Almeida
Vânia
V
Ribeiro
Rosana De A
Rde A
Frussa
Filho Roberto
FR
D018759:Adrenergic Uptake Inhibitors / Q000633:toxicity; D000818:Animals; D003292:Convulsants / Q000633:toxicity; D004195:Disease Models, Animal; D004357:Drug Synergism; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D009574:Nitro Compounds; D011422:Propionates / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000633:toxicity*
D018759:Adrenergic Uptake Inhibitors; D003292:Convulsants; D009574:Nitro Compounds; D011422:Propionates; D012110:Reserpine; C015392:3-nitropropionic acid