Early death of mice cloned from somatic cells.
Here we report that the lifespan of mice cloned from somatic cells is significantly shorter than that of genotype- and sex-matched controls, most likely due to severe pneumonia and hepatic failure. This finding demonstrates the possibility of long-term deleterious effects of somatic-cell cloning, even after normal birth.
Ogonuki
Narumi
N
Department of Veterinary Science, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.
Inoue
Kimiko
K
Yamamoto
Yoshie
Y
Noguchi
Yoko
Y
Tanemura
Kentaro
K
Suzuki
Osamu
O
Nakayama
Hiroyuki
H
Doi
Kunio
K
Ohtomo
Yukiko
Y
Satoh
Michiko
M
Nishida
Akira
A
Ogura
Atsuo
A
D000818:Animals; D019976:Cloning, Organism; D006822:Hybrid Cells; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D017093:Liver Failure; D051379:Mice; D011014:Pneumonia; D000644:Quaternary Ammonium Compounds / Q000378:metabolism; D016019:Survival Analysis
D000644:Quaternary Ammonium Compounds; D007770:L-Lactate Dehydrogenase