[Effect of preoperative chemotherapy on apoptosis and tissues of pancreatic adenocarcinoma].
OBJECTIVE
To investigate the apoptosis and tissues change of pancreatic adenocarcinoma with or without preoperative chemotherapy and discuss the effect of preoperative regional chemotherapy on pancreatic adenocarcinoma cell.


METHODS
Using the method of TUNEL and microscope, we determined the apoptosis of tumor cells and tissues changes in 30 pancreatic adenocarcinoma patients with or without preoperative chemotherapy.


RESULTS
The ratio of apoptosis was much higher in the preoperatively treated group than in the untreated group (44.87 +/- 27.78) and (3.6 +/- 3.76)/HP, (P < 0.01). The ratio of apoptosis was related to the tissue type of pancreatic adenocarcinoma. The ratio of apoptosis in the highly differentiated adenocarcinoma group was much higher than that in the middle or low differentiated adenocarcinoma group (P < 0.05, P < 0.01). The inflammatory reaction and the proliferous intima of vessels were more obvious in the preoperatively treated group than in the untreated group (P < 0.05, P < 0.01).


CONCLUSIONS
Preoperative regional chemotherapy can effectively inhibit pancreatic adenocarcinoma by inducing the apoptosis of tumor cells.
Liao
Q
Q
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730.
Zhao
Y
Y
Cai
L
L
Chen
J
J
Liu
T
T
Zhu
Y
Y
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D003131:Combined Modality Therapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy