Optimal dose of amoxicillin in treatment of otitis media caused by a penicillin-resistant pneumococcus strain in the gerbil model.
Amoxicillin at doses of 0.2 to 5 mg/kg of body weight was administered for the treatment of pneumococcal otitis media in a gerbil model. Doses greater than or equal to 2.5 mg/kg, which resulted in concentrations in middle ear fluid of > or = 1.4 microg/ml and concentrations in serum higher than the MIC (1 microg/ml) for > or = 14% of the dosing interval, were both clinically and bacteriologically effective.
Parra
Araceli
A
Department of Medical Microbiology, Fundación Jiménez Díaz, Madrid, Spain.
Ponte
Carmen
C
Cenjor
Carlos
C
García-Calvo
Gloria
G
Giménez
María José
MJ
Aguilar
Lorenzo
L
Soriano
Francisco
F
D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D015169:Colony Count, Microbial; D007758:Ear, Inner / Q000382:microbiology; D005260:Female; D005849:Gerbillinae; D008826:Microbial Sensitivity Tests; D010033:Otitis Media / Q000188:drug therapy* / Q000382:microbiology; D010403:Penicillin Resistance; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use*; D011008:Pneumococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D010406:Penicillins; D000658:Amoxicillin