[CD44v and nm23-H1 gene product expression and its clinical significance in human recurrent bladder cancer].
OBJECTIVE
To investigate the expression of the CD44v and nm23-H1 gene products and its clinical significance in human recurrent bladder cancer.


METHODS
The CD44v and nm23-H1 gene products in 45 cases of bladder cancer were analysed quantitatively by flow cytometry and cytoimmunofluorescence staining.


RESULTS
The CD44v gene product overexpression and nm23-H1 gene product low expression were correlated with invasive extent and recurrence of bladder cancer (P < 0.05). The correlation coefficients between CD44v gene product and nm23-H1 gene product were gamma = -0.2876 in bladder cancer. The correlation coefficients between CD44v gene product and nm23-H1 gene product were gamma = -0.4238 in recurrent bladder cancer.


CONCLUSIONS
The expression of CD44v and nm23-H1 gene product cooperated in growth and progress of bladder cancer. Both CD44v and nm23-H1 gene products were an objective indication of invasive extent and recurrence of bladder cancer.
Li
B
B
Department of Urology, 254th Hospital of People's Liberation Army, Tianjin 300142.
Li
Y
Y
Dai
Q
Q
Zhu
J
J
Jia
J
J
D000328:Adult; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D054778:NM23 Nucleoside Diphosphate Kinases; D009364:Neoplasm Recurrence, Local / Q000378:metabolism*; D009701:Nucleoside-Diphosphate Kinase / Q000096:biosynthesis*; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000378:metabolism*
D018960:Hyaluronan Receptors; D054778:NM23 Nucleoside Diphosphate Kinases; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase