title: Potential role of hematopoietic stem cell transplantation in children with secondary acute lymphocytic leukemia.
abstract: Secondary acute lymphocytic leukemias (ALL) are uncommon events in the pediatric patient population. There are few detailed reports on the laboratory characteristics and clinical course of patients with secondary lymphocytic leukemia. Historically, these patients have had a poor outcome. We report two patients treated at one institution who developed treatment-related secondary ALL. Both patients underwent hematopoietic stem cell transplantation, one with a compatible unrelated donor cord blood unit and one with an HLA-matched sibling donor bone marrow. One of the two patients survives disease-free 3 years after transplantation.
authors.affiliation: Pediatric Hematology/Oncology, Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Melemed
authors.forename: G
authors.initials: G
authors.lastname: Vance
authors.forename: P K
authors.initials: PK
authors.lastname: Kotylo
authors.forename: F O
authors.initials: FO
authors.lastname: Smith
mesh_terms: D002051:Burkitt Lymphoma / Q000188:drug therapy; D002675:Child, Preschool; D005260:Female; D006648:Histocompatibility; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D016609:Neoplasms, Second Primary / Q000628:therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D033581:Stem Cell Transplantation; D016896:Treatment Outcome; D009396:Wilms Tumor / Q000188:drug therapy / Q000532:radiotherapy