Negatively charged liposomes as immunological adjuvant for tetanus and diphtheria toxoids.
The aim of this study is to develop the previous research on tetanus toxoid and improve the level of antibodies against tetanus and diphtheria toxoids using liposomes as adjuvant. The results show that negatively charged liposomes enhance the immune effects of the combination of the two vaccines.
Popescu
C
C
Cantacuzino Institute, Bucharest, Romania.
Durbaca
S
S
Ivanov
D
D
D000276:Adjuvants, Immunologic; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000097:blood; D003017:Clostridium tetani / Q000276:immunology; D003353:Corynebacterium diphtheriae / Q000276:immunology; D004165:Diphtheria / Q000517:prevention & control; D004168:Diphtheria Toxoid / Q000008:administration & dosage* / Q000276:immunology; D006168:Guinea Pigs; D007115:Immunization Schedule; D008081:Liposomes; D009500:Neutralization Tests; D013742:Tetanus / Q000517:prevention & control; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000276:immunology; D014611:Vaccination / Q000379:methods*
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D008081:Liposomes; D013745:Tetanus Toxoid