Rheumatoid arthritis. The genetic components.
Rheumatoid arthritis is a multifactorial disease, with genetic, environmental, and stochastic components to its susceptibility. The search for susceptibility genes is still in progress. Preliminary results suggest the involvement of multiple genes, each with relatively modest effect. Genes within the major histocompatibility complex appear to have the strongest influence on disease susceptibility.
Jawaheer
Damini
D
Division of Biology and Human Genetics, North Shore University Hospital, Manhasset, New York, USA.
Gregersen
Peter K
PK
D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D015995:Prevalence
D006680:HLA Antigens