Diastereoselective synthesis of protected syn 1,3-diols: preparation of the C16-C24 portion of Dolabelides.
We have designed a new method to make synthons encompassing a protected syn 1,3-diol motif and an aldehyde alpha to the 1,3-dioxane ring. An additional stereocenter was also created, potentially leading to stereochemically defined 1,2,4-triols. This method was successfully applied to the synthesis of the C16-C24 portion of Dolabelides.
Grimaud
Laurence
L
Laboratoire Chimie et Procédés, Ecole Nationale Supérieure des Techniques Avancées, 32 boulevard Victor, F-75015 Paris, France.
de Mesmay
Romain
R
Prunet
Joëlle
J
D004224:Diterpenes / Q000138:chemical synthesis*; D015394:Molecular Structure; D013237:Stereoisomerism
D004224:Diterpenes