[Is the lung a target organ in inflammatory bowel disease?].
Inflammatory bowel disease is a systemic illness that may involve the lung. The most common manifestation of pulmonary involvement is an asymptomatic reduction in lung transfer factor for carbon monoxide (Dlco) and a small airway disorders easy to find in subjects with active disease. Some patients show a bronchial inflammation and suppuration with or without bronchiectasis poorly responsive to antibiotics but responding dramatically to inhaled steroids. Others present a severe tracheal inflammation and obstruction with an inflammatory mass bulging into the tracheal lumen, these subjects usually respond to methylprednisolone, in rare cases an emergency laser ablation may be necessary. Interstitial lung disease and pulmonary infiltrate with eosinophilia are the most difficult patterns to address because in some cases drugs such as sulfasalazina and 5-aminosalicylate may play a contributing role.
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Divisione di Medicina, Divisione di Chirurgia, Presidio Ospedaliero di Fiorenzuola, Azienda Ospdaliera, Cortomaggiore.
Fornasari
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D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use; D001982:Bronchial Diseases / Q000188:drug therapy / Q000209:etiology; D001987:Bronchiectasis / Q000188:drug therapy / Q000209:etiology; D002648:Child; D003093:Colitis, Ulcerative / Q000150:complications; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000188:drug therapy; D008171:Lung Diseases / Q000188:drug therapy / Q000209:etiology*; D017563:Lung Diseases, Interstitial / Q000188:drug therapy / Q000209:etiology; D011657:Pulmonary Eosinophilia / Q000209:etiology; D012129:Respiratory Function Tests; D012907:Smoking / Q000009:adverse effects; D012460:Sulfasalazine / Q000009:adverse effects / Q000627:therapeutic use; D013997:Time Factors; D014133:Tracheal Diseases / Q000188:drug therapy / Q000209:etiology
D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005765:Gastrointestinal Agents; D012460:Sulfasalazine; D001241:Aspirin