title: Ischemic brain tissue salvaged from infarction by the GP IIb/IIIa platelet antagonist tirofiban.
abstract: In an open pilot study, the authors tested whether the nonpeptide glycoprotein (GP) IIb/IIIa antagonist tirofiban, a highly effective and selective blocker of platelet aggregation, prevents the transition of ischemic brain tissue into the infarct proper as defined by MRI (perfusion-weighted/T2-weighted) in patients with acute ischemic stroke. The infarct volume (T2 lesion after 1 week) was smaller in treated patients (n = 10) compared with matched control subjects (n = 10; p = 0.029) with similar initial perfusion deficit (TTP-maps). The authors conclude that GP IIb/IIIa antagonists have therapeutic potential in acute stroke therapy.
authors.affiliation: Department of Neurology, University Hospital Düsseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Junghans
authors.forename: R J
authors.initials: RJ
authors.lastname: Seitz
authors.forename: A
authors.initials: A
authors.lastname: Ritzl
authors.forename: H-J
authors.initials: HJ
authors.lastname: Wittsack
authors.forename: G R
authors.initials: GR
authors.lastname: Fink
authors.forename: H-J
authors.initials: HJ
authors.lastname: Freund
authors.forename: M
authors.initials: M
authors.lastname: Siebler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D011446:Prospective Studies; D000077466:Tirofiban; D014443:Tyrosine / Q000008:administration & dosage* / Q000031:analogs & derivatives*
chemical_list: D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D014443:Tyrosine; D000077466:Tirofiban