title: Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during 2 years of therapy.
abstract: For a number of antiretroviral drugs, prolonged suppression of viral replication is related to drug exposure. Therefore, it is important to maintain stable concentrations during prolonged therapy. While studies suggest that saquinavir concentrations decrease over time, we show that concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid are stable during 2 years of therapy.
authors.affiliation: National Aids Therapy Evaluation Center (NATEC), Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Rieneke M E
authors.initials: RM
authors.lastname: van Praag
authors.forename: Elisabeth C M
authors.initials: EC
authors.lastname: van Weert
authors.forename: Rolf P G
authors.initials: RP
authors.lastname: van Heeswijk
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Zhou
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Sommadossi
authors.forename: Suzanne
authors.initials: S
authors.lastname: Jurriaans
authors.forename: Joep M A
authors.initials: JM
authors.lastname: Lange
authors.forename: Richard M W
authors.initials: RM
authors.lastname: Hoetelmans
authors.forename: Jan M
authors.initials: JM
authors.lastname: Prins
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D019540:Area Under Curve; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D013997:Time Factors
chemical_list: D019380:Anti-HIV Agents