title: [Systemic therapy of hemangioma].
abstract: For life-threatening hemangiomas where surgical or laser techniques are not feasible, systemic therapy with cortisone or interferon represents the therapy of choice. With response rates of 80-90%, both drugs are equally effective. Both treatments, however, might be associated with severe side-effects. Among these the risk of interferon-induced neurotoxicity has to be given special mention. Thus, the indication for systemic therapy of hemangiomas has to be made carefully, weighing up risk and benefit.
authors.affiliation: Kinderklinik und Kinderpoliklinik im Dr. v. Haunerschen Kinderspital, Lindwurmstrasse 4, 80337 München.
authors.forename: N
authors.initials: N
authors.lastname: Nohe
authors.forename: K
authors.initials: K
authors.lastname: Kurnik
authors.forename: R
authors.initials: R
authors.lastname: Grantzow
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy*; D002675:Child, Preschool; D003348:Cortisone / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006391:Hemangioma / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007372:Interferons / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D012983:Soft Tissue Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D007372:Interferons; D003348:Cortisone