[Chemoprevention of (pre)malignant disorders of the head and neck area. Current situation].
A brief review is presented of various ongoing chemoprevention studies on head and neck cancer. Although beta carotene and several retinoids seem to be effective, scientific proof is at yet insufficient. The need of biomarkers as intermediate end-points is stressed.
de Vries
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Afdeling Keel-, Neus en Oorheelkunde, Academisch Ziekenhuis Vrije Universiteit, Amsterdam.
Snow
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GB
D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use; D015415:Biomarkers; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D011230:Precancerous Conditions / Q000188:drug therapy / Q000517:prevention & control*; D012176:Retinoids / Q000008:administration & dosage / Q000627:therapeutic use; D019207:beta Carotene / Q000008:administration & dosage / Q000627:therapeutic use
D016588:Anticarcinogenic Agents; D000975:Antioxidants; D015415:Biomarkers; D012176:Retinoids; D019207:beta Carotene