Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance.
The syntheses and SAR studies of various quinazolinone compounds are described for the dual inhibition of Pgp and MRP1 in multidrug resistance.
Wang
Shouming
S
Department of Medicinal Chemistry, Xenova Ltd., 957 Buckingham Avenue, Slough, Berkshire SL1 4NL, UK. shouming_wang@xenova.co.uk
Ryder
Hamish
H
Pretswell
Ian
I
Depledge
Paul
P
Milton
John
J
Hancox
Timothy C
TC
Dale
Ian
I
Dangerfield
Wendy
W
Charlton
Peter
P
Faint
Richard
R
Dodd
Rory
R
Hassan
Stephanie
S
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D000903:Antibiotics, Antineoplastic / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D003630:Daunorubicin / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D004317:Doxorubicin / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D004347:Drug Interactions; D018432:Drug Resistance, Multiple; D006801:Humans; D020128:Inhibitory Concentration 50; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D011799:Quinazolines; D004317:Doxorubicin; D003630:Daunorubicin