title: Estrogenic activities of chemicals in diesel exhaust particles.
abstract: In a previous study, we focused on estrogenic activity of the hexane extract of diesel exhaust particles (DEP). The extract of hexane was first fractionated to acidic, phenolic and neutral portions according to their chemical properties, of which the neutral fraction was fractionated by column chromatography on silica gel. The chemical structures of compounds in these fractions were then analyzed. It was found that the neutral fraction of the hexane extract of DEP contains dibenzothiophene derivatives, one of which, 4,6-dimethyldibenzothiophene, possesses estrogenic activity.
authors.affiliation: Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan. mori@hoku-iryo-u.ac.jp
authors.forename: Yoki
authors.initials: Y
authors.lastname: Mori
authors.forename: Shinji
authors.initials: S
authors.lastname: Taneda
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Akiyo
authors.initials: A
authors.lastname: Sakushima
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kamata
authors.forename: Akira K
authors.initials: AK
authors.lastname: Suzuki
authors.forename: Shin
authors.initials: S
authors.lastname: Yoshino
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Sakata
authors.forename: Masaru
authors.initials: M
authors.lastname: Sagai
authors.forename: Koh-ichi
authors.initials: K
authors.lastname: Seki
mesh_terms: D004968:Estrogens, Non-Steroidal / Q000737:chemistry / Q000633:toxicity*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011960:Receptors, Estrogen / Q000378:metabolism; D012441:Saccharomyces cerevisiae; D013876:Thiophenes / Q000737:chemistry / Q000633:toxicity; D001335:Vehicle Emissions / Q000032:analysis / Q000633:toxicity*
chemical_list: C414426:4,6-dimethyldibenzothiophene; D004968:Estrogens, Non-Steroidal; D007202:Indicators and Reagents; D011960:Receptors, Estrogen; D013876:Thiophenes; D001335:Vehicle Emissions