[A clinical analysis of L-dopa induced dyskinesia treated by posteroventral pallidotomy for Parkinson's disease].
OBJECTIVE
To evaluate the outcome of microelectrode-guided posteroventral pallidotomy (PVP) for L-dopa induced dyskinesia in patients with Parkinson's disease.


METHODS
Thirty-six patients with dyskinesia were evaluated with unified Parkinson's disease rating scale (UPDRS) before and after operation. Duration and disability of dyskinesia were analyzed respectively.


RESULTS
The total surgical improvement for dyskinesia was 76.2%. Duration improvement was 88.8% and disability 79.7%. Significant change (P < 0.05) happened postoperatively. Seventeen patients were followed up for 3 months. The result showed a stable improvement for dyskinesia.


CONCLUSIONS
L-dopa induced dyskinesia may disappear or be improved after PVP. Surgical treatment promises a maximum L-dopa therapy without any severe pharmaceutical complications. Synergic treatment of drug and surgery are a new strategy for Parkinson's disease.
Zhao
G
G
Beijing Institute of Functional Neurosurgery, Beijing Xuanwu Hospital, Beijing 100053.
Li
Y
Y
Shao
M
M
Ding
Y
Y
D000328:Adult; D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects*; D003131:Combined Modality Therapy; D004409:Dyskinesia, Drug-Induced / Q000209:etiology / Q000601:surgery*; D005260:Female; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D008297:Male; D008839:Microelectrodes; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000601:surgery*; D013238:Stereotaxic Techniques; D016896:Treatment Outcome
D000978:Antiparkinson Agents; D007980:Levodopa