title: [The content of double bonds in blood serum lipids from patients with myocardial infarction].
abstract: Hypocholesterolemia and hypotriglyceridemia during the first days of myocardial infarction (MI) is a result of enhanced absorption of saturated fatty acids in the form of triglycerides within very low density lipoproteins (VLDL) through apoE/B-100 receptors. This is followed by inhibition of this endocytosis, accumulation of saturated fatty acids VLDL in the blood, and hypertriglyceridemia. Permanent level of double bonds in MI (ozone titration) results not from MI but from blocking of cell absorption of polyenic fatty acids in the form of cholesterol polyesters in low-density lipoproteins (LDL) through apoB-100 receptors, which is characteristic of atherosclerosis. High molar ratio of double bonds/cholesterol in comparison with the double bonds/glycerol ratio indicates that the majority of polyenic fatty acids in the blood lipoproteins present as cholesterol polyesters. Lipoprotein transfer and cell absorption of saturated fatty acids alone are selectively impaired in MI. Selective impairment of cell absorption of saturated or polyenic fatty acids alone or a combination of both is observed in some diseases. Ozone titration of serum lipid double bonds reflects impaired absorption of essential polyenic fatty acids by cells.
authors.forename: V N
authors.initials: VN
authors.lastname: Titov
authors.forename: D M
authors.initials: DM
authors.lastname: Lisitsyn
authors.forename: I I
authors.initials: II
authors.lastname: Staroverov
authors.forename: V A
authors.initials: VA
authors.lastname: Ameliushkina
authors.forename: M G
authors.initials: MG
authors.lastname: Tvorogova
mesh_terms: D000328:Adult; D000368:Aged; D002788:Cholesterol Esters / Q000097:blood / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000097:blood / Q000737:chemistry; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D011973:Receptors, LDL / Q000378:metabolism; D014280:Triglycerides / Q000097:blood / Q000737:chemistry*
chemical_list: D002788:Cholesterol Esters; D008055:Lipids; D008074:Lipoproteins; D011973:Receptors, LDL; D014280:Triglycerides