[Expression and significance of AR in osteosarcoma].
OBJECTIVE
To determine the relationship between AR and pathological characteristics of osteosarcoma and to investigate the potential role of AR in the pathogenesis of osteosarcoma.


METHODS
AR in the samples of the paraffin embedded tissues from 65 cases of osteosarcoma was immunohistochemically detected by streptavidin/peroxidase (SP) method. The pathology of osteosarcoma was classified and graded according to Liu Zijun's Classification.


RESULTS
The positive rate of AR was 50.8% (33/65). The positive particles were distributed in the cytoplasm and nucleus. The positive rate of AR in osteosarcoma with higher grade of cell differentiation was lower than that in the tumor with lower one. There was no significant difference in different pathological type of osteosarcoma.


CONCLUSIONS
AR exists in osteosarcoma and its positive rate is related to the cell differentiation of osteosarcoma.
Liu
J
J
Department of Orthopaedics, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China.
Chen
X
X
Li
S
S
Yue
X
X
Li
Y
Y
D001859:Bone Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012516:Osteosarcoma / Q000378:metabolism* / Q000473:pathology; D011944:Receptors, Androgen / Q000378:metabolism*
D011944:Receptors, Androgen