[Pathological changes following retrograde infusion of methyl violet in the parotid gland of the miniature pig].
OBJECTIVE
To investigate the pathologic changes induced by infusion of 1% methyl violet in the parotid gland of the miniature pig (minipig).


METHODS
Methyl violet (either 0.6 ml, 1.0 ml, or 4.0 ml) was injected into parotid glands of fifteen minipigs. The parotid glands were harvested for gross and histopathologic study after 1 week, 2 weeks, 1 month, 3 months and 6 months.


RESULTS
The pathological changes induced by retrograde injection of methyl violet included necrosis or atrophy of acinar cells and fibrosis of the gland. The ductal system underwent atrophic changes, and thrombotic obliteration of main duct.


CONCLUSIONS
Retrograde infusion of 1% methyl violet results in complete atrophy and fibrosis of the parotid gland in the minipig.
Li
J
J
Beijing Hospital for Stomatology, Capital University of Medical Sciences, Beijing 100050.
Wang
S
S
Zhu
X
X
D000818:Animals; D001284:Atrophy / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005260:Female; D005355:Fibrosis / Q000139:chemically induced; D005840:Gentian Violet / Q000008:administration & dosage* / Q000633:toxicity; D007260:Infusion Pumps; D008297:Male; D010306:Parotid Gland / Q000187:drug effects* / Q000473:pathology; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors
D005840:Gentian Violet