Peptide YY and cancer: current findings and potential clinical applications.
Peptide YY (PYY) is a naturally occurring gut hormone with mostly inhibitory actions on multiple tissue targets. PYY has been identified in several carcinoid tumors and a decreased expression of PYY may be relevant to the development and progression of colon adenocarcinoma. Treatment with PYY decreases growth in pancreatic and breast tumors, most likely through a reduction in intracellular cAMP. In cancer patients, PYY may also improve malnutrition that results from iatrogenic causes or cachexia associated with advanced disease. PYY plays a significant role in multiple aspects of cancer from regulation of cell growth to potential therapeutic applications.
Tseng
William W
WW
Northwestern University Medical School, Chicago, Illinois 60611, USA.
Liu
Carson D
CD
D000230:Adenocarcinoma / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism; D002100:Cachexia / Q000378:metabolism; D002276:Carcinoid Tumor / Q000378:metabolism*; D002455:Cell Division; D003110:Colonic Neoplasms / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D010190:Pancreatic Neoplasms / Q000378:metabolism; D019894:Peptide YY / Q000235:genetics* / Q000378:metabolism*; D013997:Time Factors
D019894:Peptide YY; D000242:Cyclic AMP