title: [Changes in the collagen structures of human heart valves in relation to age and hypertension].
abstract: Using polarization microscopy and morphometrical methods, the influence of hypertension on the collagenous structures in the Lamina fibrosa of bicuspid valves of 14 middle-aged persons (30 to 50 years) were examined. The measurements were performed on histological sections. A group of 14 middle-aged subjects free from heart disease served as the control group. Furthermore, the results were compared to earlier findings on the histological biomorphosis of the atrioventricular valves. The following changes were observed and quantitatively determined: a) an enhancement of the percentage of the mechanically more resistant collagenous fibers (unsilvered, type I collagen), b) a stronger lateral aggregation of the collagenous fibrils of both types I and III collagen, c) a significant decrease of the total numbers of collagenous fibers per measuring area, and d) a significant decrease of the portion of silvered fibers (type III collagen) per measuring area for both sexes. The fiber density distributions confirm the observed changes: in the hypertension group the collagenous fibers are less densely distributed than in the control group. The observed regression of the content of collagenous fibers in the hypertension group is probably due to the anti-hypertensive treatment. Following the findings the turn-over of type III collagen is stronger influenced than that of type I collagen. The initial results determined in human heart valves confirm findings in animal models and characterize them with regard to the collagen types mentioned.
authors.affiliation: Institut für Anatomie, Universität Leipzig Liebigstr. 13 04103 Leipzig, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Keller
authors.forename: A
authors.initials: A
authors.lastname: Pflug
authors.forename: Y
authors.initials: Y
authors.lastname: Lehmann
mesh_terms: D000328:Adult; D000367:Age Factors; D003094:Collagen / Q000378:metabolism*; D024042:Collagen Type I / Q000378:metabolism; D024061:Collagen Type III / Q000378:metabolism; D005260:Female; D006351:Heart Valves / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000473:pathology*; D008297:Male; D008859:Microscopy, Polarization; D008875:Middle Aged; D012016:Reference Values
chemical_list: D024042:Collagen Type I; D024061:Collagen Type III; D003094:Collagen