Nitric oxide and apoptosis in mesangial cells.
Nitric oxide and apoptosis in mesangial cells. Radicals such as nitric oxide (NO) or superoxide (O(-)(2)) encompass the ability to initiate morphological and biochemical alterations that are reminiscent of apoptosis. In mesangial cells, death as a result of NO formation is efficiently antagonized by the simultaneous presence of superoxide (O(-)(2)) and vice versa. This article reviews the consequences of a diffusion controlled NO/O(-)(2) interaction with the outcome of redirecting the apoptotic initiating activity of either NO or O(-)(2) toward protection. The crosstalk between cell destructive and protective pathways, and their activation or inhibition under the modulatory influence of NO and/or O(-)(2) are summarized.
Brüne
Bernhard
B
Department of Cell Biology, University of Kaiserslautern, Erwin-Schrödinger-Strasse, 67663 Kaiserslautern, Germany. bruene@rhrk.uni-kl.de
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D005920:Glomerular Mesangium / Q000166:cytology / Q000502:physiology*; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species; D009569:Nitric Oxide