title: Multiple sclerosis-associated retrovirus (MSRV) in Sardinian MS patients.
abstract: Blood and CSF of Sardinian patients with MS and neurologic control subjects were tested for MS-associated retrovirus (MSRV). CSF detection in MS was 50% at clinical onset, increasing with temporal disease progression, and 40% in control subjects. In blood, MSRV was detected in all MS patients, in most patients with inflammatory neurologic diseases, and rarely in healthy blood donors. MSRV may represent a marker of neurologic diseases of inflammatory origin.
authors.affiliation: Section of Experimental and Clinical Microbiology, Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, I-07100 Sassari. doleivir@ssmain.uniss.it
authors.forename: A
authors.initials: A
authors.lastname: Dolei
authors.forename: C
authors.initials: C
authors.lastname: Serra
authors.forename: G
authors.initials: G
authors.lastname: Mameli
authors.forename: M
authors.initials: M
authors.lastname: Pugliatti
authors.forename: G
authors.initials: G
authors.lastname: Sechi
authors.forename: M C
authors.initials: MC
authors.lastname: Cirotto
authors.forename: G
authors.initials: G
authors.lastname: Rosati
authors.forename: S
authors.initials: S
authors.lastname: Sotgiu
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000821:virology*; D015995:Prevalence; D012190:Retroviridae / Q000302:isolation & purification*; D012192:Retroviridae Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000453:epidemiology*