title: Waveforms of the ductus venosus blood flow in normal human fetuses aged 8-38 weeks.
abstract: BACKGROUND
  We attempted to establish normal Doppler flow velocity waveform patterns in the human fetal ductus venosus (DV), and also to establish a standardized measurement technique.
  
  
  METHODS
  Ductus venosus blood flow was measured in a prospective study involving 545 fetuses aged between 8 and 38 weeks in utero, the mothers of whom received prenatal care in Kaohsiung Chang Gung Memorial Hospital in a 12-month period in 1998-1999. Several DV hemodynamic parameters were assessed, including peak systolic velocity (DVP), peak systolic/diastolic (S/D) ratio, time-averaged velocity (TAMX), maximum velocity during atrial contraction (DVM), pulsatility index (PI), Pourcelot's resistance index (RI), and fetal heartbeat (FHB).
  
  
  RESULTS
  Technically acceptable ductus venosus blood flow velocity waveform patterns were collected from 490 of 545 pregnant women (89.9%). The mean +/- SD value for the peak systolic DV velocity during the time period of 8 to 38 weeks in utero was 0.33 +/- 0.11 meters/sec (m/s), the TAMX being 0.24 +/- 0.09 m/s. The maximum velocity during atrial contraction was 0.15 +/- 0.09 m/s, and the peak S/D velocity ratio was 2.5 +/- 1.01. The PI, Pourcelot's RI and fetal heart beat were, 0.67(+/- 0.21), 0.64 (+/- 0.11), and 163.3 (+/- 18.82 bpm), respectively. Significant increases in DVP, TAMX, and DVM with advancing gestational age were established, and decreases in PI, RI, S/D, and FHB with advancing gestational age were also observed.
  
  
  CONCLUSIONS
  Further investigation of DV hemodynamics throughout pregnancy may enable a greater understanding of normal placental perfusion, the fetal venous return to the heart and associated cardiac function.
authors.affiliation: Department of Obstetrics & Gynecology, Chang Gung Memorial Hospital, Niaosung, Taiwan, ROC. joanyeh@cgmh.org.tw
authors.forename: T Y
authors.initials: TY
authors.lastname: Hsu
authors.forename: C Y
authors.initials: CY
authors.lastname: Ou
authors.forename: S Y
authors.initials: SY
authors.lastname: Chang
authors.forename: B H
authors.initials: BH
authors.lastname: Cheng
authors.forename: J H
authors.initials: JH
authors.lastname: Chen
authors.forename: P H
authors.initials: PH
authors.lastname: Hsu
authors.forename: W L
authors.initials: WL
authors.lastname: Tsai
mesh_terms: D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D005260:Female; D005333:Fetus / Q000098:blood supply*; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies