title: Limits to lifespan.
abstract: It has long-been accepted that normal somatic cells have intrinsic mechanisms that limit their proliferative lifespan. Recent work has now challenged this view by demonstrating that extrinsic factors might be determining proliferative potential.
authors.affiliation: Cancer Research Campaign, MRC Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK. alison.lloyd@ucl.ac.uk
authors.forename: Alison C
authors.initials: AC
authors.lastname: Lloyd
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods*; D002455:Cell Division / Q000502:physiology*; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000502:physiology*; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D006801:Humans; D010641:Phenotype; D015398:Signal Transduction / Q000502:physiology; D019098:Telomerase / Q000378:metabolism
chemical_list: D019098:Telomerase