title: Trends in species causing fungaemia in a tertiary care medical centre over 12 years.
abstract: Trends in the species of yeast causing fungaemia over a 12-year period at a large tertiary care medical centre were reviewed. A total of 966 unique episodes of fungaemia occurred in 898 patients. There was an overall trend toward fewer fungaemic episodes due to Candida albicans and more due to Candida glabrata and Candida parapsilosis. However, C. albicans remained the predominant species causing fungaemia, and the proportion due to other species varied from year to year. Candida glabrata was disproportionately isolated from older adults, whereas C. parapsilosis was common among neonates and infants. The trends of increasing isolation of C. glabrata and decreasing isolation of C. albicans were associated with increasing usage of fluconazole, but changes in the proportion of fungaemias due to other species appeared to have no association with fluconazole usage.
authors.affiliation: Department of Internal Medicine, Veterans Affairs Healthcare System, University of Michigan Medical School, Ann Arbor 48105, USA.
authors.forename: P N
authors.initials: PN
authors.lastname: Malani
authors.forename: S F
authors.initials: SF
authors.lastname: Bradley
authors.forename: R S
authors.initials: RS
authors.lastname: Little
authors.forename: C A
authors.initials: CA
authors.lastname: Kauffman
mesh_terms: D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002175:Candida / Q000145:classification* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D016469:Fungemia / Q000382:microbiology*; D006753:Hospital Records; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008824:Michigan; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors