title: Experimental Trypanosoma evansi infection in South American coati (Nasua nasua): hematological, biochemical and histopathological changes.
abstract: The course of an experimental Trypanosoma evansi infection in coatis (Nasua nasua, carnivora, Procyonidae) was followed for 262 days. Hematological analysis of the infected coatis revealed a marked decline in hemoglobin, packed-cell volume, and total erythrocyte count. An intense anemia followed the first wave of parasitemia and persisted until the end of the experimental period. Biochemical analysis showed increased serum levels of alanine aminotransferase and aspartate aminotransferase and decreased albumin. The main histopathological features consisted of myocarditis with the presence of degenerate cardiac fibers and meningoencephalitis. This study has shown that coatis infected with T. evansi develop a chronic disease.
authors.affiliation: Department of Veterinary Pathology, State University of São Paulo, Av. Carlos Tonani s/no, km 05, 14870-000, Jaboticabal/SP, São Paulo, Brazil. herrera@ioc.fiocruz.br
authors.forename: H M
authors.initials: HM
authors.lastname: Herrera
authors.forename: A C
authors.initials: AC
authors.lastname: Alessi
authors.forename: L C
authors.initials: LC
authors.lastname: Marques
authors.forename: A E
authors.initials: AE
authors.lastname: Santana
authors.forename: L P C T
authors.initials: LP
authors.lastname: Aquino
authors.forename: R F
authors.initials: RF
authors.lastname: Menezes
authors.forename: M A V
authors.initials: MA
authors.lastname: Moraes
authors.forename: R Z
authors.initials: RZ
authors.lastname: Machado
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000740:Anemia / Q000473:pathology / Q000662:veterinary; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002335:Carnivora / Q000469:parasitology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D008590:Meningoencephalitis / Q000473:pathology / Q000662:veterinary; D009205:Myocarditis / Q000473:pathology / Q000662:veterinary; D009206:Myocardium / Q000473:pathology; D018512:Parasitemia / Q000662:veterinary; D010273:Parasitic Diseases, Animal / Q000097:blood / Q000469:parasitology / Q000473:pathology*; D012709:Serum Albumin / Q000032:analysis; D014345:Trypanosoma; D014352:Trypanosomiasis / Q000473:pathology / Q000662:veterinary*
chemical_list: D012709:Serum Albumin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase