Abrogation of Ref1 retrovirus restriction in human cells.
We have previously described postentry restriction of murine leukemia virus in mammals. Here we characterize the block in human cells. Restricted infection kinetics are multiple hit at high virus dose, and restriction is abrogated by preexposure to restricted virus. We hypothesize that restricted capsid can titrate out the restriction factor.
Towers
Greg
G
Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, London W1T 4JF, United Kingdom.
Collins
Mary
M
Takeuchi
Yasuhiro
Y
D000818:Animals; D002213:Capsid / Q000235:genetics / Q000378:metabolism; D002460:Cell Line; D005822:Genetic Vectors; D006801:Humans; D009052:Leukemia Virus, Murine / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D007942:Leukemia, Experimental / Q000821:virology; D051379:Mice; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D012192:Retroviridae Infections / Q000821:virology; D014412:Tumor Virus Infections / Q000821:virology
D011506:Proteins