Identification of a novel allele HLA-B*7805 in a Japanese female.
A new HLA-B*78 allele, B*7805, was identified in a healthy Japanese female. The results of her serological HLA class I typing showed an unusual Bw4/Bw6 pattern with strongly positive reactivity to anti-Bw6, i.e. A24, -, B52, -, Bw4, Bw6. In DNA typing, she was typed as A*24, -, B*52, B*78-like, Cw1202, -, (Bw4, Bw6). Cloning and sequencing of exon 2 and exon 3 of her B locus genes revealed a new allele B*7805. The cloned B*7805 differed from B*78021 by three nucleotide substitutions in exon 2 at position 259 (A to G), 261 (C to G) and 272 (A to C), and contained sequences defining Bw6 motif in the region of codon 77 to 83.
Sekimoto
T
T
Hokkaido Red Cross Blood Center, Sapporo, Japan.
Araseki
M
M
Sato
S
S
Sakaya
S
S
Kato
T
T
Ikeda
H
H
D000483:Alleles; D000595:Amino Acid Sequence / Q000235:genetics*; D001483:Base Sequence; D017931:DNA Primers; D005091:Exons; D005260:Female; D015235:HLA-B Antigens / Q000032:analysis* / Q000235:genetics*; D006801:Humans; D007564:Japan; D008969:Molecular Sequence Data
D017931:DNA Primers; D015235:HLA-B Antigens