Concerning two-metal cooperativity in model phosphate hydrolysis.
Three series of bimetallic ligands were tested for cooperativity in the hydrolysis of phosphate esters. It was shown that rate enhancements were in part contributed by binding to the hydrophobic linkers when the substrates were also hydrophobic, and two metal cooperativity was not found to be present. Kinetic order tests were performed and shown to be superior to previous methods for analyzing cooperativity.
Leivers
M
M
Department of Chemistry, Columbia University, New York, New York 10027, USA.
Breslow
R
R
D002384:Catalysis; D015226:Dinucleoside Phosphates / Q000737:chemistry; D006868:Hydrolysis; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008024:Ligands; D009596:Nitrophenols / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D010755:Organophosphates; D009943:Organophosphorus Compounds / Q000737:chemistry*
C436487:2-(hydroxypropyl)-4-nitrophenyl phosphate; D015226:Dinucleoside Phosphates; D008024:Ligands; D009596:Nitrophenols; D009942:Organometallic Compounds; D010755:Organophosphates; D009943:Organophosphorus Compounds; C026519:uridine monophosphate-uridine; C002887:bis(4-nitrophenyl)phosphate