Meiosis activating sterols derived from diosgenin.
Continuing research based on the meiosis activation properties of the endogenous sterol FF-MAS is reported. The synthesis and SAR of 16- and 26-substituted sterols are described, utilising diosgenin as starting material. Selected sterols were tested for their ability to induce oocyte maturation in hypoxanthine arrested mouse oocytes in vitro.
Murray
Anthony
A
Novo Nordisk A/S, Novo Nordisk Park, 2760, Maløv, Denmark. amur@novodisk.com
Grøndahl
Christian
C
Ottesen
Jan L
JL
Faarup
Peter
P
D000818:Animals; D004144:Diosgenin / Q000737:chemistry*; D005299:Fertility Agents / Q000138:chemical synthesis; D008540:Meiosis / Q000187:drug effects*; D051379:Mice; D009865:Oocytes / Q000187:drug effects; D013261:Sterols / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D005299:Fertility Agents; D013261:Sterols; D004144:Diosgenin