title: [Expression of cell adhesion molecule CD44 variant isoform correlated with the clinical behavior of renal cell carcinoma].
abstract: OBJECTIVE
  To determinate whether the expression of CD44v in renal cell carcinoma (RCC) is associated with tumor malignant behavior.
  
  
  METHODS
  Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect CD44v in 31 human renal cell carcinoma (RCC) in addition to 18 normal renal tissues from patients with non-malignant disease.
  
  
  RESULTS
  Eighteen RCCs showed positive expression while none of normal renal tissue expressed CD44v (P < 0.001). CD44v was expressed in metastatic or high pathological stage RCC, but the expression of CD44v was not correlated with cellular differentiation.
  
  
  CONCLUSIONS
  Our data indicate that a role for CD44v in human RCC progression and metastases, and CD44v may prove to be a marker for high metastasis potential of RCC.
authors.affiliation: Department of Urology, Li Huili Hospital, Ningbo Medical Center, Ningbo 315040.
authors.forename: H
authors.initials: H
authors.lastname: Long
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.forename: Z
authors.initials: Z
authors.lastname: Guo
authors.forename: C
authors.initials: C
authors.lastname: Yan
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics*; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D020033:Protein Isoforms / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D018960:Hyaluronan Receptors; D020033:Protein Isoforms