title: Long-term biological investigations in space.
abstract: Missions in space within the next two decades will be of longer duration than those carried out up to the present time, and the effects of such long-term flights on biological organisms are unknown. Results of biological experiments that have been performed to date cannot be extrapolated to results in future flights because of the unknown influence of adaptation over a long period of time. Prior experiments with Axolotl, fishes, and vertebrates by our research team (in part with sounding rockets) showed that these specimens did not appear to be suitable for long-term missions on which minimization of expense, technique, and energy is required. Subsequent investigations have shown the suitability of the leech (Hirudo medicinalis), which consumes blood of mammals up to ten times its own weight (1 g) and can live more than 2 years without further food supply. Emphasis in the experiments with Hirudo medicinalis is placed on metabolic rhythm and motility. Resorption and diffusion in tissue, development, and growth under long-term effects of cosmic proton radiation and zero-gravity are other focal points. The constancy of cellular life in the mature animals is a point in favor of these specimens. We have also taken into account the synergistic effects of the space environment on the problems just mentioned. The life-support system constructed for the leech has been tested successfully in four sounding rocket flights and, on that basis, has been prepared for a long-term mission. Long-term investigations out of the terrestrial biosphere will provide us with information concerning the degree of adaptation of certain physiological and biochemical functions and as to what extent biological readjustment or repair processes can occur under the specific stress conditions of space flight.
authors.affiliation: Extraterrestrische Biologie Universitat Frankfurt.
authors.forename: R G
authors.initials: RG
authors.lastname: Lotz
authors.forename: H
authors.initials: H
authors.lastname: Fuchs
authors.forename: U
authors.initials: U
authors.lastname: Bertsche
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D002940:Circadian Rhythm / Q000502:physiology / Q000528:radiation effects; D003359:Cosmic Radiation; D004625:Embryo, Nonmammalian; D004867:Equipment Design; D005720:Gamma Rays; D007865:Leeches / Q000196:embryology / Q000502:physiology* / Q000528:radiation effects; D008021:Life Support Systems / Q000295:instrumentation*; D008027:Light; D018499:Linear Energy Transfer; D011522:Protons; D012107:Research Design; D013026:Space Flight; D014893:Weightlessness
chemical_list: D011522:Protons