title: Necrolytic migratory erythema associated with glucagonoma syndrome: a case report.
abstract: Necrolytic migratory erythema is a rare skin condition that consists of migrating areas of erythema with blisters that heal with hyperpigmentation. It usually occurs in patients with an alpha islet cell tumor of the pancreas-or glucagonoma-and when associated with glucose intolerance, anemia, hyperglucagonemia, and weight loss defines the glucagonoma syndrome. We describe a 52-year-old female patient with necrolytic migratory erythema associated with glucagonoma syndrome who had metastatic disease at presentation and passed away one week after her admission. The autopsy showed a tumor in the body of the pancreas, which was diagnosed as a neuroendocrine tumor and confirmed by immunohistochemistry. The diagnosis of necrolytic migratory erythema is a matter of great importance, since it might be an auxiliary tool for the early detection of glucagonoma.
authors.affiliation: Department of Dermatology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, Brazil.
authors.forename: C C
authors.initials: CC
authors.lastname: Dal Coleto
authors.forename: A P
authors.initials: AP
authors.lastname: de Mello
authors.forename: J
authors.initials: J
authors.lastname: Piquero-Casals
authors.forename: F R
authors.initials: FR
authors.lastname: Lima
authors.forename: M A
authors.initials: MA
authors.lastname: Vilela
authors.forename: C
authors.initials: C
authors.lastname: Festa-Neto
authors.forename: J A
authors.initials: JA
authors.lastname: Sanches
mesh_terms: D004890:Erythema / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005935:Glucagonoma / Q000150:complications* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000473:pathology; D013577:Syndrome