title: Recurrence of pneumococcal meningitis due to primary spontaneous cerebrospinal fluid fistulas.
abstract: The authors report a case of pneumococcal meningitis which recurred 3 times in a Taiwanese boy due to spontaneous cerebrospinal fluid (CSF) fistulas. The first time occurred at the age of 2 years, and the second episode presented as meningoencephalomyelitis at the age of 6 years 10 months. Studies including serum levels of immunoglobulin and complements, brain magnetic resonance imaging, and coronal cranial computed tomography (CT) were negative for a specific etiology. The third episode of meningitis developed 2 months after the second episode. Repeated immunological studies and high-resolution CT of paranasal sinuses and temporal bones were negative. Technetium-99m diethylenetriamine pentaacetic acid (Tc-99m-DTPA) radionuclide cisternography revealed abnormal retention of radioactivity over the right mastoid area. Neurosurgery was undertaken to seal the dural tear and pack the petrosal fissure. Two years after surgery, he has had no further CSF leak age or meningitis. Tracing back the history, there was no head injury, cranial surgery, brain tumor, or hydrocephalus, which might have created CSF fistulas. Primary spontaneous CSF fistulas constitute the most reasonable diagnosis. In cases of recurrent bacterial meningitis, underlying anatomic defects should be carefully evaluated if there is no immune defect.
authors.affiliation: Division of Pediatric Neurology, Chang Gung Children's Hospital, Taipei, ROC.
authors.forename: H Y
authors.initials: HY
authors.lastname: Wen
authors.forename: M L
authors.initials: ML
authors.lastname: Chou
authors.forename: K L
authors.initials: KL
authors.lastname: Lin
authors.forename: P F
authors.initials: PF
authors.lastname: Kao
authors.forename: J F
authors.initials: JF
authors.lastname: Chen
mesh_terms: D002559:Cerebrospinal Fluid Rhinorrhea / Q000209:etiology; D002648:Child; D005402:Fistula / Q000150:complications*; D006801:Humans; D008297:Male; D008586:Meningitis, Pneumococcal / Q000209:etiology*; D012008:Recurrence; D016284:Technetium Tc 99m Pentetate
chemical_list: D016284:Technetium Tc 99m Pentetate