Elevated basal ganglia glucose metabolism in cyclosporine neurotoxicity: a positron emission tomography imaging study.
Abnormally increased 18F-fluorodeoxyglucose uptake in the basal ganglia was noted by positron emission tomography (PET) in a 37-year-old bone marrow transplant patient who had severe intention tremors of his hands and a progressive psychiatric change with social withdrawal and flat affect. This is the first PET report on metabolic abnormalities in cyclosporine neurotoxicity. It emphasizes the need for more research to understand the pathophysiology of these changes.
Meyer
Michael Andrew
MA
Positron Emission Tomography Imaging Division, Lucy Dent Imaging Center, Dent Neurologic Institute, Buffalo, New York, USA. mmeyer@dentinstitute.com
D000328:Adult; D001479:Basal Ganglia / Q000000981:diagnostic imaging* / Q000378:metabolism*; D016572:Cyclosporine / Q000009:adverse effects*; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed; D014202:Tremor / Q000139:chemically induced
D007166:Immunosuppressive Agents; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D016572:Cyclosporine; D005947:Glucose