title: [Pharmacokinetical study of safflor yellow on rat acute model of blood stasis syndrome].
abstract: OBJECTIVE
  To study the pharmacokinetical character of safflor yellow in rat acute model of blood stasis syndrome.
  
  
  METHODS
  The rat acute model of blood stasis syndrome was made by i.p. adrenalin (0.07 ml/kg) and the stimulation of ice-water. At the time of 5, 10, 30, 60, 120, 180, 320, 480 min, the concentration of safflor yellow in the serum after i.v. safflor yellow (37.08 ml/kg) was determined.
  
  
  RESULTS
  The concentration-time date of safflor yellow in rat acute model of blood stasis syndrome was shown to fit a double-compartment open model, t1/2 alpha = 1.43 min, t1/2 beta = 95.65 min, AUC = 49,632.90 micrograms.min/ml; while the concentration-time data of safflor yellow in normal rat was shown to fit a single-compartment open model, t1/2 alpha = 66.27 min, AUC = 42,267 micrograms.min/ml.
  
  
  CONCLUSIONS
  The metabolism of safflor yellow was evidently later in rat acute model of blood stasis syndrome than in normal rat.
authors.affiliation: Xijing Hospital, Fourth Military Medical University, Xi'an 710032.
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
authors.forename: A
authors.initials: A
authors.lastname: Wen
authors.forename: Q
authors.initials: Q
authors.lastname: Mei
authors.forename: Y
authors.initials: Y
authors.lastname: Jiang
authors.forename: M
authors.initials: M
authors.lastname: Zhao
authors.forename: S
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000208:Acute Disease; D000818:Animals; D002599:Chalcone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D018056:Hemorheology; D008297:Male; D008516:Medicine, Chinese Traditional; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C076422:safflower yellow; D002599:Chalcone