Molecular mycology: a genetic toolbox for Histoplasma capsulatum.
Research in medical mycology has traditionally been a mix of exciting biology and frustrating genetics, although the excitement has been steadily increasing as genetic obstacles have been successfully overcome. Now, a variety of fungal pathogens can be studied using molecular techniques derived from classical bacterial and yeast genetics, but with selective and strategic adaptations. Histoplasma capsulatum is the best-studied of the primary pathogens known as 'dimorphic' fungi, and tailored molecular genetic strategies are beginning to reveal a repertoire of genes and gene products intimately associated with pathogenesis.
Magrini
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Washington University School of Medicine, Dept of Molecular Microbiology, Campus Box 8230, St Louis, MO 63110, USA.
Goldman
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D004251:DNA Transposable Elements / Q000235:genetics; D015966:Gene Expression Regulation, Fungal; D017930:Genes, Reporter / Q000235:genetics / Q000502:physiology*; D005822:Genetic Vectors / Q000378:metabolism*; D006658:Histoplasma / Q000235:genetics* / Q000254:growth & development* / Q000472:pathogenicity*; D006660:Histoplasmosis / Q000276:immunology* / Q000382:microbiology*; D016254:Mutagenesis, Insertional / Q000235:genetics / Q000502:physiology; D011995:Recombination, Genetic; D014170:Transformation, Genetic
D004251:DNA Transposable Elements