title: [Vena cava filter in patients with gynecologic cancer complicated by pulmonary embolism and progressive hypercoagulability].
abstract: The aim of the study was to verify the validity of placement of a vena cava filter in patients with gynecologic cancer complicated by pulmonary embolism and progressive persistent hypercoagulability. The authors discuss two patients with pulmonary embolism. In this study, a gynecologic tumor was diagnosed, one presented endometrial carcinoma and the other ovarian papillary carcinoma, after the position of vena cava filter and treatment with urokinasi (2.800.000 UI/ml) it was possible to do surgery followed by radiation therapy in the first case and chemotherapy in the second. In these cases there are indications for the placement of a vena cava filter. This has enabled surgery and anticoagulation therapy and has prevented the movement of any other emboli, which were later dissolved by fibrinolytic agents, and the effectiveness result was the arrest of progressive hypercoagulability moved by tumor cell. The serious conditions that were related to prior embolism and to a persistent thrombotic state characterized by progressive hypercoagulability did not make it possible to perform surgery or any other type of therapy because of absolute contraindications. The decision to place the filter could thus become the first step towards subsequent improvements, that are also tied to the possibility of performing surgery for removing tumor, arrest of progressive hypercoagulability due to tumor cell, allow chemotherapy or radiation treatment.
authors.affiliation: Facoltà di Medicina e Chirurgia, Dipartimento di Ostetricia e Ginecologia, Seconda Università degli Studi, Napoli, Italy. luigicobellis@yahoo.it
authors.forename: L
authors.initials: L
authors.lastname: Cobellis
authors.forename: E M
authors.initials: EM
authors.lastname: Messalli
authors.forename: E
authors.initials: E
authors.lastname: Calabrese
authors.forename: E
authors.initials: E
authors.lastname: Pecori
authors.forename: E
authors.initials: E
authors.lastname: Gioino
authors.forename: G
authors.initials: G
authors.lastname: Cobellis
mesh_terms: D018196:Carcinoma, Adenosquamous / Q000150:complications*; D002291:Carcinoma, Papillary / Q000150:complications*; D018450:Disease Progression; D016889:Endometrial Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications*; D011655:Pulmonary Embolism / Q000150:complications / Q000628:therapy*; D019851:Thrombophilia / Q000150:complications / Q000628:therapy*; D016306:Vena Cava Filters