Gene therapy and solid-organ transplantation.
Recent developments in transplantation medicine improved the short- and long-term survival of solid-organ transplantation. However, chronic allograft rejection, the side effects of the long-term immunosuppressive treatment, and organ shortage are still the major obstacles to achieving long-term survival. Gene therapy has the potential to meet these challenges and has unique advantages in transplantation. In this review we summarize the studies using gene therapy in solid-organ transplantation.
Akalin
Enver
E
Division of Nephrology and Institute of Molecular Medicine and Gene Therapy, and Recanati-Miller Transplant Institute, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.
Bromberg
Jonathan S
JS
D000818:Animals; D015316:Genetic Therapy; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D014181:Transplantation Immunology