Synthesis and antimicrobial activities of novel naphtho[2,1-b]pyran, pyrano[2,3-d]pyrimidine and pyrano[3,2-e][1,2,4]triazolo[2,3-c]-pyrimidine derivatives.
The synthesis of new naphtho[1',2':5,6]pyrano[2,3-d]pyrimidines and related heterocycles has been reported. The key intermediate 3-amino-8-bromo-1-(p-methoxyphenyl)-1H-naphtho[2,1-b] pyran-2-carbonitrile (3c) was obtained in one pot synthesis by treating alpha-cyanocinnamonitrile (1c) with 6-bromo-2-naphthol (2). Antimicrobial activity was shown for some of the synthesized compounds.
Bedair
A H
AH
Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.
Emam
H A
HA
El-Hady
N A
NA
Ahmed
K A
KA
El-Agrody
A M
AM
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000138:chemical synthesis / Q000494:pharmacology*; D011714:Pyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D006576:Heterocyclic Compounds, 4 or More Rings; D009281:Naphthalenes; D011714:Pyrans; D011743:Pyrimidines; D014230:Triazoles; C476004:naphtho(2,1-b)pyran; C476007:pyrano(2,3-d)pyrimidine; C476005:pyrano(3,2-e)(1,2,4)triazolo(2,3-c)-pyrimidine