title: Ocular histopathological changes after eyeball enucleation induced by corneal trauma.
abstract: OBJECTIVE
  To observe the ocular histopathological changes after eyeball enucleation induced by corneal trauma.
  
  
  METHODS
  Light microscopic examination was done on 117 eyeball specimens enucleated after corneal trauma (18 with corneal fissure and 99 with corneal perforating trauma).
  
  
  RESULTS
  Acute, subacute or chronic inflammatory changes, and fibrous membrane formation were observed in well-closed corneal wounds, whereas inflammation, atrophy and scar were observed in the focal tissues. But at the late period, secondary glaucoma, retinal detachment, endophthalmitis and eyeball atrophy resulted in blindness. Corneal fistula was observed in those with inadequate cure of wounds caused by ingrowth of corneal epithelium, embedment of iris and vitreous body, and large area of centrally located tissue deficiency of the corneal. A high incidence of endophthalmitis was noted due to the presence of corneal fistula. Severe inflammation was observed in the anterior segmental tissues with fibrous infiltration in the anterior chamber, which might result in rapid destruction of the eyeballs.
  
  
  CONCLUSIONS
  Ocular pathology varies with the difference of the position, form, size and closing conditions of the corneal laceration after trauma.
authors.affiliation: Department of Ophthalmology, Affiliated Hospital, Medical College, Qingdao University, Qingdao, 266003, China.
authors.forename: G
authors.initials: G
authors.lastname: Zhao
authors.forename: W
authors.initials: W
authors.lastname: Sun
authors.forename: Y
authors.initials: Y
authors.lastname: Niu
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Cao
authors.forename: Y
authors.initials: Y
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000473:pathology*; D065306:Corneal Injuries; D015353:Eye Enucleation; D006801:Humans; D007223:Infant; D008875:Middle Aged