title: Normal outcome of pregnancy in chronic myeloid leukemia treated with interferon-alpha in 1st trimester: report of 3 cases and review of the literature.
abstract: Three patients with chronic myeloid leukemia (CML) in chronic phase received interferon-alpha during pregnancy, starting from the 1st trimester. No maternal complications were reported. The 3 patients delivered normal looking babies apart from one baby who was found to have transient mild thrombocytopenia. Subsequently these children were followed for 30, 12, and 4 months and all had normal growth and development.
authors.affiliation: Hamad Medical Corporation, Department of Medicine, Hematology/Oncology Division, Doha, Qatar.
authors.forename: A A S
authors.initials: AA
authors.lastname: Mubarak
authors.forename: I R
authors.initials: IR
authors.lastname: Kakil
authors.forename: A
authors.initials: A
authors.lastname: Awidi
authors.forename: U
authors.initials: U
authors.lastname: Al-Homsi
authors.forename: Z
authors.initials: Z
authors.lastname: Fawzi
authors.forename: M
authors.initials: M
authors.lastname: Kelta
authors.forename: A
authors.initials: A
authors.lastname: Al-Hassan
mesh_terms: D000328:Adult; D005260:Female; D005865:Gestational Age; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First
chemical_list: D016898:Interferon-alpha