title: Importance of RDW value in differential diagnosis of hypochrome anemias.
abstract: Red cell distribution width (RDW) was studied in adults carrying delta-beta thalassemia traits (deltabeta-TT) who were 20-40 years of age (n = 29), beta thalassemia traits (beta-TT) with an age range of 18-60 years (n = 49), iron deficiency anemia (IDA) in individuals aged 1-18 years (n = 27), and in controls with an age range of 20-40 years (n = 20). Although red blood cell count, MCV, and MCH values showed no statistically significant differences between deltabeta-TT and beta-TT, the mean RDW value was significantly higher in deltabeta-TT (20.14 +/- 1.21) compared to beta-TT (14.88 +/- 1.77) (P < 0.001). No difference was observed between the means of RDW in deltabeta-TT and IDA (18.00 +/- 1.94) (P > 0.05). A significant rise in RDW in IDA 5-7 days after initiation of iron therapy (P = 0.00) which was continued to rise up to the 4(th) week of therapy was suggested as an important tool in differentiation of IDA from deltabeta-TT. These observations could be kept in mind in the differential diagnosis of deltabeta-TT from beta-TT and IDA by determining the red blood cell count, red cell indices, and RDW only.
authors.affiliation: Department of Pediatric Hematology, Ihsan Doğramaci Children's Hospital, Hacettepe University, Ankara, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Aslan
authors.forename: F
authors.initials: F
authors.lastname: Gümrük
authors.forename: A
authors.initials: A
authors.lastname: Gürgey
authors.forename: C
authors.initials: C
authors.lastname: Altay
mesh_terms: D000293:Adolescent; D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood; D048429:Cell Size; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000473:pathology*; D006801:Humans; D007223:Infant; D008875:Middle Aged; D017086:beta-Thalassemia / Q000097:blood*