title: Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism.
abstract: We present the results of a study using vibrational circular dichroism (VCD) for (+)-1, which furnished an unambiguous determination of its absolute configuration as S. The most abundant conformation of (+)-1 in CDCl(3) solution was also established.
authors.affiliation: The R.W. Johnson Pharmaceutical Research Institute, Drug Discovery, Spring House, Pennsylvania 19477-0766, USA.
authors.forename: Alexey B
authors.initials: AB
authors.lastname: Dyatkin
authors.forename: Teresa B
authors.initials: TB
authors.lastname: Freedman
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Cao
authors.forename: Rina K
authors.initials: RK
authors.lastname: Dukor
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Maryanoff
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Maryanoff
authors.forename: Jay M
authors.initials: JM
authors.lastname: Matthews
authors.forename: Rekha D
authors.initials: RD
authors.lastname: Shah
authors.forename: Laurence A
authors.initials: LA
authors.lastname: Nafie
mesh_terms: D065092:Antidiuretic Hormone Receptor Antagonists; D001569:Benzodiazepines / Q000737:chemistry*; D002942:Circular Dichroism; D008968:Molecular Conformation; D012997:Solvents; D013055:Spectrophotometry, Infrared
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D012997:Solvents; D001569:Benzodiazepines