title: Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset.
abstract: Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands. bonifati@kgen.fgg.eur.nl
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Bonifati
authors.forename: Guido J
authors.initials: GJ
authors.lastname: Breedveld
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Squitieri
authors.forename: Nicola
authors.initials: N
authors.lastname: Vanacore
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Brustenghi
authors.forename: Biswadjiet S
authors.initials: BS
authors.lastname: Harhangi
authors.forename: Pasquale
authors.initials: P
authors.lastname: Montagna
authors.forename: Milena
authors.initials: M
authors.lastname: Cannella
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fabbrini
authors.forename: Patrizia
authors.initials: P
authors.lastname: Rizzu
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: Ben A
authors.initials: BA
authors.lastname: Oostra
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Meco
authors.forename: Peter
authors.initials: P
authors.lastname: Heutink
mesh_terms: D000328:Adult; D017668:Age of Onset; D002878:Chromosomes, Human, Pair 1; D005192:Family Health; D005260:Female; D006801:Humans; D008025:Ligases / Q000235:genetics; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000235:genetics*; D010375:Pedigree; D044767:Ubiquitin-Protein Ligases
chemical_list: D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D008025:Ligases