title: [Type B natriuretic peptide in the diagnosis of heart failure with preserved systolic function].
abstract: BACKGROUND
  Heart failure (HF) with preserved left ventricular systolic function (LVSF) is observed in up to 50% patients with HF. There is no consensus on non-invasive diagnosis of this entity.
  
  
  OBJECTIVE
  Evaluation of B-type natriuretic peptide (BNP) in the diagnosis of HF with preserved left ventricular systolic function.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  One hundred and seventy-six consecutive patients with suspected HF were evaluated. Patients were classified as having HF with preserved LVSF, if they had symptoms and signs of HF, an ejection fraction greater than 40% and an abnormal Doppler pattern of the mitral inflow or atrial fibrilation and no other causes for the symptoms. All patients had a 12-lead EKG, chest roentgenogram, simple spirometry, M-mode and 2D echocardiogram with pulsed Doppler study of transmitral inflow and determination of plasma BNP levels.
  
  
  RESULTS
  Of the 176 patients, 65 had ejection fraction greater than 40%. Of these patients 46 were classified as having HF with preserved LVSF and 19 as not having HF. Patients with HF and preserved LVSF were older, had a higher systolic blood pressure (SBP), less pathologic Q waves on ECG and higher left ventricular ejection fraction and plasma BNP than patients without HF. Multivariate analysis revealed that BNP and SBP were independently associated with the diagnosis of HF. The accuracy of BNP in the diagnosis of HF with preserved LVSF evaluated by the area under the receiver operating characteristic curve was 0.94.
  
  
  CONCLUSIONS
  These results suggest that the measurement of BNP levels can help clinicians in the diagnosis of HF with preserved LVSF. Whether BNP levels might be used in clinical practice as a test for the diagnosis of HF with preserved LVSF is a question that merits further studies.
authors.affiliation: Serviço de Medicina 3, Serviço de Cardiologia, Hospital S. João, Porto.
authors.forename: A
authors.initials: A
authors.lastname: Castro
authors.forename: P
authors.initials: P
authors.lastname: Dias
authors.forename: M
authors.initials: M
authors.lastname: Pereira
authors.forename: J
authors.initials: J
authors.lastname: Pimenta
authors.forename: F
authors.initials: F
authors.lastname: Friões
authors.forename: R
authors.initials: R
authors.lastname: Rodrigues
authors.forename: A
authors.initials: A
authors.lastname: Ferreira
authors.forename: P
authors.initials: P
authors.lastname: Bettencourt
mesh_terms: D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain; D011446:Prospective Studies; D013599:Systole
chemical_list: D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor