Influence of anatomical location on arterial thrombosis.
Atherosclerosis manifests as a systemic disease with near global involvement of the named segments of the arterial tree. Acute thrombotic arterial occlusion, however, is not equally distributed. To evaluate intra-individual regional differences in arterial thrombogenicity, we compared (111)In-platelet deposition in porcine carotid and femoral arteries after a standardized crush injury. Within the unidirectional flow conditions of elastic carotid arteries, platelet deposition was more than 3-fold higher compared with predominantly muscular femoral arteries with triphasic arterial flow. To determine the influence of rheology on platelet deposition after crush injury, carotid arteries were transplanted into the femoral position and compared with the paired native carotid and femoral arteries. Similarly, femoral arteries transposed to the carotid position were compared with the paired native carotid artery. In each of these experiments, arterial transposition to a new anatomic location imparts a predilection for platelet deposition indigenous to the new location. In the controlled environment of two high-shear thrombin-independent and -dependent flow chambers, porcine carotid and femoral arterial substrates were indistinguishable from one another with respect to platelet deposition. Regional differences in arterial hemodynamics may account for substantial differences in thrombosis arising from deep arterial injury.
Karnicki
Krzysztof
K
Division of Cardiovascular Medicine, Mayo Clinic and Foundation for Education and Research, Rochester, MN 55905, USA.
Komorowicz
Erzsebet
E
Fass
David N
DN
Owen
Whyte G
WG
McBane
Robert D
RD
D000818:Animals; D001158:Arteries / Q000000981:diagnostic imaging / Q000293:injuries / Q000503:physiopathology*; D002339:Carotid Arteries / Q000637:transplantation; D003187:Compliance; D005260:Female; D005263:Femoral Artery / Q000293:injuries / Q000637:transplantation; D006439:Hemodynamics; D015539:Platelet Activation; D012039:Regional Blood Flow; D013552:Swine; D013927:Thrombosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*; D014463:Ultrasonography; D014949:Wounds, Nonpenetrating / Q000150:complications / Q000503:physiopathology / Q000601:surgery