Genomic analyses of microbial virulence.
Genomic sequencing of bacterial pathogens is providing an increasing wealth of new data. It is, however, still unclear how this information can be used to develop new experimental approaches. Here, we describe recent efforts to complement existing bacterial genetics with genomic methods for the study of pathogenesis.
Sassetti
Christopher
C
Department of Immunology and Infectious Diseases, Harvard School of Public Health, 667 Huntington Avenue, Boston, MA 02115, USA.
Rubin
Eric J
EJ
D001419:Bacteria / Q000235:genetics* / Q000472:pathogenicity*; D019295:Computational Biology; D004251:DNA Transposable Elements; D015870:Gene Expression; D020411:Oligonucleotide Array Sequence Analysis; D017422:Sequence Analysis, DNA / Q000379:methods; D014774:Virulence
D004251:DNA Transposable Elements