Alcohol-induced alterations in blood and erythrocyte membrane in diabetics.
Three groups consisting of 12 volunteers each, of alcoholic type 2 diabetics (non-insulin-dependent diabetes mellitus, NIDDM), non-alcoholic type 2 diabetics (NIDDM) and controls (teetotallers) were selected for assessing changes in lipids of plasma and erythrocyte membranes. Significant changes in cholesterol and phospholipids were observed in alcoholic diabetics suggesting a regulatory compensatory mechanism to resist the fluidizing action of ethanol as well as rigidification of erythrocyte membrane. A significant increase in lipid peroxidation of erythrocytes was observed, indicating the damage associated with disrupted organization, structure and function of membranes in alcoholic diabetics.
Paramahamsa
M
M
Department of Biochemistry, Sri Krishnadevaraya University, Anantapur 515003, A. P., India.
Aparna
S
S
Varadacharyulu
N
N
D000328:Adult; D000437:Alcoholism / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010743:Phospholipids / Q000097:blood
D008054:Lipid Peroxides; D010743:Phospholipids; D008315:Malondialdehyde