Rare acquired bleeding disorders.
Accurate diagnosis of the cause of bleeding is a prerequisite for determination of the optimal therapeutic response. Clinicians are generally aware of the more prevalent hemorrhagic syndromes but some rare acquired conditions are also of importance. In many of these, inhibitors of coagulation factors or of platelet adhesion/aggregation cause bleeding. These inhibitors are generally, but not always, immunoglobulins. In this review, the less common inhibitors of coagulation and hemostasis, as well as some important but rare nutritional, iatrogenic and disease associated hemorrhagic disorders, are described.
Watson
H G
HG
Department of Medicine and Therapeutics, University of Aberdeen, Polworth Building, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK.
Chee
Y L
YL
Greaves
M
M
D001323:Autoantibodies / Q000097:blood; D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000209:etiology*; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000276:immunology; D064420:Drug-Related Side Effects and Adverse Reactions; D006470:Hemorrhage / Q000139:chemically induced / Q000209:etiology / Q000276:immunology; D006474:Hemorrhagic Disorders / Q000175:diagnosis / Q000209:etiology*; D006801:Humans
D001323:Autoantibodies; D001779:Blood Coagulation Factors