Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model system.
A significant difference in blood-acetaldehyde concentration was observed between high alcohol-preference (HAP) rats and low alcohol-preference (LAP) rats, newly developed different alcohol preference lines. This difference of acetaldehyde accumulation may be due to cytosolic aldehyde dehydrogenase (ALDH1) polymorphism, which has been reported previously. As the doses of ethanol we employed are higher than that of voluntary drinking, there may be little direct relationship between acetaldehyde accumulation and alcohol preference. We suggest therefore that the ALDH1 polymorphism is associated with alcohol preference in HAP/LAP lines through some other unidentified mechanism.
Nishiguchi
Minori
M
Department of Legal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501 Japan.
Kinoshita
Hiroshi
H
Mostofa
Jamal
J
Taniguchi
Tadaaki
T
Ouchi
Harumi
H
Minami
Takako
T
Hatake
Katsuhiko
K
Utsumi
Takao
T
Motomura
Hiroyuki
H
Hishida
Shigeru
S
D000079:Acetaldehyde / Q000097:blood*; D000428:Alcohol Drinking / Q000235:genetics; D000437:Alcoholism / Q000097:blood / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D000080924:Aldehyde Dehydrogenase 1 Family; D000818:Animals; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005518:Food Preferences; D007527:Isoenzymes / Q000235:genetics; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D050697:Retinal Dehydrogenase; D012641:Selection, Genetic
D002492:Central Nervous System Depressants; D007527:Isoenzymes; D000431:Ethanol; D000080924:Aldehyde Dehydrogenase 1 Family; D000444:Aldehyde Dehydrogenase; C515028:ALDH1A1 protein, mouse; C523119:Aldh1a1 protein, rat; D050697:Retinal Dehydrogenase; D000079:Acetaldehyde