Microbial epoxide hydrolases for preparative biotransformations.
Epoxide hydrolases from microbial sources are highly versatile biocatalysts for the asymmetric hydrolysis of epoxides on a preparative scale. Besides kinetic resolution, which furnishes the corresponding vicinal diol and remaining non-hydrolysed epoxide in nonracemic form, enantioconvergent processes are possible: these are highly attractive as they lead to the formation of a single enantiomeric diol from a racemic oxirane. The data accumulated over recent years reveal a common picture of the substrate structure selectivity pattern of microbial epoxide hydrolases and indicate that substrates of various structural types can be selectively hydrolysed with enzymes from certain microbial sources.
Steinreiber
A
A
Department of Chemistry, Organic and Bio-organic Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
Faber
K
K
D001426:Bacterial Proteins / Q000737:chemistry*; D001709:Biotechnology / Q000379:methods; D002384:Catalysis; D004851:Epoxide Hydrolases / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry; D006868:Hydrolysis; D007700:Kinetics; D008956:Models, Chemical
D001426:Bacterial Proteins; D004852:Epoxy Compounds; D004851:Epoxide Hydrolases