Expression of c-Fos after noise-induced temporary threshold shift in the guinea pig cochlea.
c-Fos is known to be a component of a transcription factor, activator protein-1, which is induced by oxidative stress. Guinea pigs were exposed to 4 kHz band noise of 110 dB SPL for 1 or 5 h and the expression of c-Fos in the organ of Corti was determined using Western blotting analysis and immunocytochemistry. c-Fos was expressed only after the noise exposure. The c-Fos expression was mainly found in the Hensen's cells, Claudius' cells and Deiter's cells of the basal and second turns of the cochlea. Since the threshold shift was temporary, the expression of c-Fos is therefore considered to contribute to the survival or protective function of the organ of Corti.
Shizuki
Ken
K
Department of Otolaryngology, National Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan. uu8k-szk@asahi-net.or.jp
Ogawa
Kaoru
K
Matsunobu
Takeshi
T
Kanzaki
Jin
J
Ogita
Kiyokazu
K
D000161:Acoustic Stimulation; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001309:Auditory Threshold / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology*; D003051:Cochlea / Q000166:cytology / Q000378:metabolism*; D006168:Guinea Pigs; D007150:Immunohistochemistry; D009622:Noise / Q000009:adverse effects*; D018384:Oxidative Stress / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D018808:Transcription Factor AP-1 / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology
D016760:Proto-Oncogene Proteins c-fos; D018808:Transcription Factor AP-1