G proteins and pheromone signaling.
All cells have the capacity to respond to chemical and sensory stimuli. Central to many such signaling pathways is the heterotrimeric G protein, which transmits a signal from cell surface receptors to intracellular effectors. Recent studies using the yeast Saccharomyces cerevisiae have produced important advances in our understanding of G protein activation and inactivation. This review focuses on the mechanisms by which G proteins transmit a signal from peptide pheromone receptors to the mating response in yeast and how mechanisms elucidated in yeast can provide insights to signaling events in more complex organisms.
Dohlman
Henrik G
HG
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA. henrik_dohlman@med.unc.edu
D019204:GTP-Binding Proteins / Q000502:physiology*; D010675:Pheromones / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D010675:Pheromones; D019204:GTP-Binding Proteins