[Thiazolidinediones and PPARgamma system in repair of liver damage].
PPAR-gamma belongs to the nuclear hormone receptor superfamily and its ligands include antidiabetic drugs of the thiazolidindione class, and endogenous molecules, including eicosanoids and fatty acids. PPAR-gamma is involved in the pathophysiology of obesity and type II diabetes. More recently, accumulating evidence suggests its role in atherosclerosis, inflammation and cancer. Recent data obtained in cellular models of liver fibrosis indicate that PPAR-gamma activation results in the inhibition of the processes leading to the development of liver fibrosis. These studies identify potential novel therapeutic strategies for the treatment of liver fibrosis.
Marra
Fabio
F
Dipartimento di Medicina Interna, Università, Firenze. f.marra@dmi.unifi.it
Pastacaldi
Sabrina
S
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000503:physiopathology; D002839:Chromans / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology; D015777:Eicosanoids / Q000502:physiology; D005227:Fatty Acids / Q000502:physiology; D005544:Forecasting; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D066298:In Vitro Techniques; D007249:Inflammation / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000503:physiopathology / Q000628:therapy*; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D009765:Obesity / Q000188:drug therapy / Q000503:physiopathology; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D012106:Research; D013844:Thiazoles / Q000494:pharmacology / Q000627:therapeutic use*; D045162:Thiazolidinediones; D014157:Transcription Factors / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D000077288:Troglitazone
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D000975:Antioxidants; D002839:Chromans; D015777:Eicosanoids; D005227:Fatty Acids; D007004:Hypoglycemic Agents; D018160:Receptors, Cytoplasmic and Nuclear; D013844:Thiazoles; D045162:Thiazolidinediones; D014157:Transcription Factors; D000077288:Troglitazone; C039671:ciglitazone