title: Brachytherapy for locally recurrent soft-tissue sarcoma.
abstract: Radiation is used to reduce potential risk of local recurrence from microscopic residual disease after surgical resection. Brachytherapy is a clinically established means of providing radiation for soft-tissue sarcomas that recur after surgical resection alone or surgical resection and radiation. Although the total dose of radiation that is prescribed is approximately the same for patients undergoing external beam radiation or brachytherapy, the radiobiologic characteristics of brachytherapy, based on the inverse-square law, provide higher doses of radiation to the surgical bed. This provides a theoretical advantage for the use of brachytherapy as compared with external beam radiation among patients with recurrence after surgical resection. When soft-tissue sarcomas recur in a previously irradiated area, further external beam radiation generally is not possible; therefore, brachytherapy allows a radiotherapeutic alternative in an attempt to reduce the risk of further local recurrence. Recommendations for patient selection, the total dose of radiation, and the radiation dose-rate are outlined. Standard grading systems for response, symptoms, and severity of complications should be used.
authors.affiliation: University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, U.S.A.
authors.forename: Nora
authors.initials: N
authors.lastname: Janjan
authors.forename: Christopher
authors.initials: C
authors.lastname: Crane
authors.forename: Marc
authors.initials: M
authors.lastname: Delclos
authors.forename: Matthew
authors.initials: M
authors.lastname: Ballo
mesh_terms: D001918:Brachytherapy; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D012509:Sarcoma / Q000532:radiotherapy* / Q000601:surgery