title: [Neoadjuvant chemotherapy and chemoradiotherapy in surgically treated non-small-cell stage III bronchial carcinoma].
abstract: Patients with unfavorable stages of lung cancer are rarely cured with local treatment modalities alone. Aim of our phase II trial was to investigate the effectivity of a multimodality treatment. Ninety-four patients with NSCLC (stage IIIA/IIIB) were treated preoperatively with chemoradiotherapy (cisplatin and etoposide, 45 Gy hyperfractionated accelerated radiotherapy). After repeat mediastinoscopy patients underwent surgery. Complete resection (R0) was achieved in 53% of all patients with NSCLC. Two patients died of sepsis preoperatively and four postoperatively (90-days lethality: 6.4%). The median survival time was 20 months for IIIA and 18 months for IIIB. Calculated survival rates at 6 years were 34% for IIIA and 17% for IIIB. This multimodality treatment demonstrates high efficacy in prognostically unfavorable NSCLC compared with historical controls.
authors.affiliation: Ruhrlandklinik Essen, Tüschenerweg 40, 45239 Essen.
authors.forename: L
authors.initials: L
authors.lastname: Hillejan
authors.forename: M R
authors.initials: MR
authors.lastname: Müller
authors.forename: W
authors.initials: W
authors.lastname: Eberhardt
authors.forename: G
authors.initials: G
authors.lastname: Stüben
authors.forename: G
authors.initials: G
authors.lastname: Stamatis
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D005047:Etoposide / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D012086:Reoperation; D015996:Survival Rate
chemical_list: D005047:Etoposide; D002945:Cisplatin