Evaluation of psychopharmacological effects of Clerodendrum phlomidis Linn. extract.
The methanolic extract of Clerodendrum phlomidis Linn. (MECP) leaves was evaluated for its psychopharmacological activities in several experimental models using Swiss albino mice and Wistar albino rats. The MECP was found to cause significant reduction in spontaneous activity, and decreases in exploratory behavioral profiles by the Y-maze and head dip test. It also showed reduction in muscle relaxant activity by rotarod, 30 degrees inclined screen and traction tests, as well as significantly potentiated the phenobarbitone sodium-induced sleeping time in the doses examined (200, 400 and 600 mg/kg body wt.). All the results were compared with respective controls for the evaluation of significance.
Murugesan
T
T
Department of Pharmaceutical Technology, Jadavpur university, Calcutta, India. goldmurugesan@yahoo.com
Saravanan
K S
KS
Lakshmi
S
S
Ramya
G
G
Thenmozhi
K
K
D000045:Acacia / Q000737:chemistry; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008954:Models, Biological; D009126:Muscle Relaxation / Q000187:drug effects / Q000502:physiology; D010634:Phenobarbital / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects; D029648:Verbenaceae
D010936:Plant Extracts; D003975:Diazepam; D010634:Phenobarbital