Botulinum toxin A for palmar hyperhidrosis.
OBJECTIVE
We evaluated the efficacy and safety of intracutaneous injections of botulinum toxin A on severe palmar hyperhidrosis.


METHODS
Ten patients with recalcitrant palmar hyperhidrosis were treated with intercutaneous injections of botulinum toxin A (Botox; 200 U for each hand). Patients were followed up to 23 months (mean +/- SD: 12.1 +/- 6.2 months). RESULTS Botulinum toxin significantly reduced abnormal sweating within 1 week in 100% of the patients. In six patients with a follow-up of 12 months or more the antisudorific effect lasted 12.3 +/- 5.5 months. The longest response duration was 22 months. Repeated treatment was performed in five patients with unchanged clinical efficacy. The only side-effect was tolerable pain from the intracutaneous injections in patients where a nerve block was not performed.


CONCLUSIONS
Botulinum toxin A (200 U Botox per palm) was able to induce long-term remission in palmar hyperhidrosis without significant acute and long-term side-effects. Strictly intracutaneous injection of small volumes is recommended. So far, response to repeated treatments did not show evidence of neutralizing antibody induction.
Wollina
U
U
Department of Dermatology and Allergology, the Friedrich-Schiller-University of Jena, Germany. Wollina-uw@khdf.de
Karamfilov
T
T
D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006225:Hand; D006801:Humans; D006945:Hyperhidrosis / Q000175:diagnosis / Q000628:therapy*; D007279:Injections, Subcutaneous; D008297:Male; D011336:Probability; D012008:Recurrence; D012720:Severity of Illness Index; D016896:Treatment Outcome
D019274:Botulinum Toxins, Type A