title: Pathological effects of lyngbyatoxin A upon mice.
abstract: Histopathological changes induced in mice by lyngbyatoxin A were studied in connection with the occurrence of the toxin in marine turtles implicated in human intoxication. Lyngbyatoxin A showed an i.p. lethal dose 250 microg/kg in immature mice (3-week old) and most severely damaged capillaries of villi in the small intestine. Immature mice were more sensitive than matured ones and died of bleeding from the small intestines. With sublethal doses were observed erosion in the stomach, small intestine, cecum, and large intestine, as well as inflammation in the lung. Time course changes observed after p.o. administration of sublethal doses indicated severe mucus secretion and injuries to occur within 60 min in the intestine and within 24h in the stomach. Increased inflammatory cells followed these injuries. The injuries in the lung, stomach, and small intestine took a few weeks for recovery. The cause of death and the effective dose levels resembled those of aplysiatoxin poisoning.
authors.affiliation: Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8673, Chiba, Japan. emiko@myco.pf.chiba-u.ac.jp
authors.forename: Emiko
authors.initials: E
authors.lastname: Ito
authors.forename: Masayuki
authors.initials: M
authors.lastname: Satake
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yasumoto
mesh_terms: D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D004064:Digestive System / Q000187:drug effects* / Q000473:pathology; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008235:Lyngbya Toxins / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051379:Mice; D013997:Time Factors
chemical_list: D002273:Carcinogens; D008235:Lyngbya Toxins; C006610:aplysiatoxin; C019457:lyngbyatoxin A