title: Angiotensin 1-7 increases quantal content and facilitation at the frog neuromuscular junction.
abstract: At the neuromuscular junction, several endogenous substances have been shown to act presynaptically to modify transmitter release. Here we show that angiotensin 1-7, a vasoactive peptide of the renin-angiotensin system, increased quantal content in a dose-dependent manner, with a maximal increase of 78% at 250 nM. At the same dose, angiotensin 1-7 increased paired pulse facilitation by 70%. This is the first report of angiotensin 1-7 altering a cholinergic synapse.
authors.affiliation: Departamento de Fisiologia e Biofísica, ICB-Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
authors.forename: Enéias Ricardo
authors.initials: ER
authors.lastname: Bevilaqua
authors.forename: Christopher
authors.initials: C
authors.lastname: Kushmerick
authors.forename: Paulo Sérgio Lacerda
authors.initials: PS
authors.lastname: Beirão
authors.forename: Lígia Araujo
authors.initials: LA
authors.lastname: Naves
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000803:Angiotensin I / Q000494:pharmacology* / Q000502:physiology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D018482:Muscle, Skeletal / Q000294:innervation; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology* / Q000502:physiology; D011892:Rana catesbeiana
chemical_list: D000959:Antihypertensive Agents; D010446:Peptide Fragments; D000803:Angiotensin I; C118790:angiotensin I (1-7); D000109:Acetylcholine