Non-T(H)1 cytokines are augmented systematically early in Guillain-Barré syndrome.
The T(H)1 vs non-T(H)1 cytokine balance in Guillain-Barré syndrome (GBS) is unknown. Using enzyme-linked immunospot (ELISPOT) assays, we observed elevated numbers of interleukin (IL)-6 and IL-10-secreting blood mononuclear cells (BMNC) during the acute phase in untreated patients, and low levels of tumor necrosis factor alpha-secreting BMNC in the recovery phase of GBS. Numbers of IL-12p70-secreting BMNC were not affected over the course of GBS. The non-T(H)1 cytokine profile observed early in GBS may explain the self-limited clinical course associated with GBS.
Press
Rayomand
R
Division of Neurology, Neuroimmunology Unit, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden. rayomand.press@neurotec.ki.se
Ozenci
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Kouwenhoven
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D000208:Acute Disease; D020275:Guillain-Barre Syndrome / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism*; D018664:Interleukin-12 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D018664:Interleukin-12