The effect of quercetin on light-induced cytotoxicity of hypericin.
Protective effect of quercetin, a natural antioxidant compound, on hypericin-induced cytotoxicity was studied in human promyelocytic leukemia cells (HL-60). Hypericin (10(-5) mol x l(-1)) alone significantly decreased cell survival to 21% that found in the controls, whereas in combination with quercetin (10(-5) mol x l(-1)) this decrease was diminished to 46%. Lower concentrations of quercetin had no protective effect. These findings indicate that oxygen radicals can play an important role in hypericin-induced phototoxic effects.
Mirossay
A
A
Department of Pharmacology, Faculty of Medicine, P.J. Safárik University, Kosice, Slovak Republic.
Onderková
H
H
Mirossay
L
L
Sarisský
M
M
Mojzis
J
J
D000873:Anthracenes; D002470:Cell Survival / Q000187:drug effects; D004347:Drug Interactions; D018922:HL-60 Cells; D006801:Humans; D008027:Light; D010569:Perylene / Q000031:analogs & derivatives* / Q000633:toxicity*; D010777:Photochemistry; D011794:Quercetin / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000633:toxicity*; D017382:Reactive Oxygen Species / Q000737:chemistry
D000873:Anthracenes; D011838:Radiation-Sensitizing Agents; D017382:Reactive Oxygen Species; D010569:Perylene; C004965:hypericin; D011794:Quercetin