Plasmapheresis: an adjunct therapy in severe progressive neuropsychiatric lupus.
OBJECTIVE
We report our experience with use of plasmapheresis (PP) as an adjunct therapy in severe progressive neuropsychiatric systemic lupus erythematosus (NPSLE).


METHODS
Three patients of NPSLE (including 2 with status epilepticus) who were progressively worsening on steroids or combination of pulse cyclophosphamide (CPM) and steroids were treated with PP followed by synchronized CPM. Pre and post treatment SLE Disease Activity Index (SLEDAI) and laboratory tests were carried out.


RESULTS
Significant clinical improvement with decrease in SLEDAI occurred immediately following PP. Mean SLEDAI before and after PP were 33 and 11. Mean erythrocyte sedimentation rate decreased from 121 to 31. Rebound flare of disease activity noted in two patients between 7th-10th day requiring additional immunosuppressants or steroids.


CONCLUSIONS
PP used as an adjunct therapy in severe, progressive NPSLE is well tolerated and can turn the patient around. PP should be followed by synchronized pulse CPM to prevent disease flare.
Gokhale
Y A
YA
Department of Medicine, LTM Medical College Sion, Mumbai.
Bhide
S
S
Rajadhyaksha
S
S
Bichile
L S
LS
Hase
N K
NK
D000293:Adolescent; D000328:Adult; D002493:Central Nervous System Diseases / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000628:therapy*; D009422:Nervous System Diseases / Q000209:etiology; D019965:Neurocognitive Disorders / Q000209:etiology; D010956:Plasmapheresis; D013997:Time Factors