title: Catechol as a nucleophilic catalyst of peptide bond formation.
abstract: The aminolysis of a mildly activated aminoacid ester, benzyloxycarbonyl-L-phenylalanine cyanomethyl ester, by glycine esters in the presence of catechol has been studied as a model of catalysis by RNA cis-vicinal-diol systems in protein biosynthesis. Catechol accelerated the aminolysis, especially in the presence of bases, probably by nucleophilic catalysis.
authors.affiliation: Laboratory of BioCatalysis, Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofia.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Ivanova
authors.forename: Emilia
authors.initials: E
authors.lastname: Bratovanova
authors.forename: Dimiter
authors.initials: D
authors.lastname: Petkov
mesh_terms: D002384:Catalysis; D002396:Catechols / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D007700:Kinetics; D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry*; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000737:chemistry; D011485:Protein Binding; D013997:Time Factors
chemical_list: D002396:Catechols; D010455:Peptides; C461640:benzyloxycarsbonylphenylalanine cyanomethyl ester; D010649:Phenylalanine; C034221:catechol