DNA hybridization arrays for gene expression analysis of human oral cancer.
DNA hybridization arrays permit global gene expression profiling to be done in a single experiment. The evolution and challenges of DNA hybridization arrays are reflected in the variety of experimental platforms, probe composition, hybridization/signal detection methods, and bioinformatic interpretation. In tumor biology, DNA hybridization arrays are being used for gene/gene pathway discovery, diagnosis, and therapeutic design. Similar applications are advancing our understanding of oral cancer cell biology.
Todd
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Laboratory of Oral & Maxillofacial Surgery, Harvard School of Dental Medicine, Boston, MA 02115, USA. randy_todd@hms.harvard.edu
Wong
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DT
D019295:Computational Biology / Q000379:methods; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000235:genetics*; D020869:Gene Expression Profiling / Q000379:methods*; D005838:Genotype; D006801:Humans; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D009693:Nucleic Acid Hybridization / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D009857:Oncogenes / Q000235:genetics; D010347:Patient Care Planning; D010641:Phenotype; D015398:Signal Transduction / Q000235:genetics
D015342:DNA Probes; D004273:DNA, Neoplasm