Recruiting the immune response to promote axon regeneration in the injured spinal cord.
Myelin contains molecules that can inhibit the growth and regeneration of axons. Neutralizing the activity of these inhibitors can enhance axon regeneration in the adult mammalian central nervous system (CNS). The complexity of the CNS-immune system interactions after CNS trauma is now beginning to be better understood. Recent studies indicate that both cell-mediated and antibody-mediated immune responses can help in promoting axon regeneration after CNS injury. It is hoped that such advances will lead to the development of safe and effective vaccine and cytokine treatments for spinal cord injuries.
David
Samuel
S
Centre for Research in Neuroscience, Montreal General Hospital Research Institute, McGill University, Quebec, Canada. sdavid11@po-box.mcgill.ca
Ousman
Shalina S
SS
D000818:Animals; D001369:Axons / Q000276:immunology* / Q000502:physiology; D002465:Cell Movement / Q000276:immunology*; D006801:Humans; D008262:Macrophage Activation / Q000276:immunology; D009186:Myelin Sheath / Q000276:immunology / Q000378:metabolism; D009416:Nerve Regeneration / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology; D013119:Spinal Cord Injuries / Q000276:immunology* / Q000473:pathology