title: Function of the Yersinia effector YopJ.
abstract: The Yersinia virulence factor YopJ inhibits the host immune response and induces apoptosis by blocking multiple signaling pathways, including the MAPK and NFkappaB pathways in the infected cell. YopJ is a cysteine protease that cleaves a reversible post-translational modification in the form of ubiquitin or a ubiquitin-like protein. Homologues of YopJ are expressed in animal and plant pathogens, as well as a plant symbiont, suggesting a universal mechanism of regulating or modulating a variety of signaling pathways. The ability of YopJ to block the innate immune response, its activity as a ubiquitin-like protein protease and its activity with respect to mammalian signalling pathways are discussed in this review.
authors.affiliation: Department of Molecular Biology, 5323 Harry Hines Boulevard, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA. kimorth@hamon.swmed.edu
authors.forename: Kim
authors.initials: K
authors.lastname: Orth
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001424:Bacterial Infections / Q000276:immunology*; D001426:Bacterial Proteins / Q000737:chemistry / Q000502:physiology*; D016923:Cell Death; D003546:Cysteine Endopeptidases / Q000378:metabolism; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism; D006790:Host-Parasite Interactions; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D025842:SUMO-1 Protein / Q000378:metabolism; D016415:Sequence Alignment; D015398:Signal Transduction; D015007:Yersinia / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D016328:NF-kappa B; D025842:SUMO-1 Protein; C109227:YopP protein, Yersinia; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; C118083:Ulp1 protease