title: Aortic wall alterations after use of gelatin-resorcinol-formalin glue.
abstract: We report the case of a patient who underwent reoperation 8 years after aortic valve replacement because of aneurysmal dilatation of the aortic root. During the initial intervention, gelatin-resorcinol-formalin glue had been applied on the outside of the aortic root. Perioperative examination revealed a necrotic appearance of the right coronary sinus, with contained ruptures at two different sites. Histologic analysis showed major destruction of the aortic root media, leading to vascular wall thinning and rupture. The use of gelatin-resorcinolformalin glue may expose patients to major alterations of the aortic wall.
authors.affiliation: Department of Cardiothoracic Surgery, Association Claude Bernard, Hĵpital Henri Mondor, Créteil, France. loisance@univparis12.fr
authors.forename: Matthias
authors.initials: M
authors.lastname: Kirsch
authors.forename: Maryvonne
authors.initials: M
authors.lastname: Ginat
authors.forename: Laure
authors.initials: L
authors.lastname: Lecerf
authors.forename: Rémi
authors.initials: R
authors.lastname: Houël
authors.forename: Daniel
authors.initials: D
authors.lastname: Loisance
mesh_terms: D001013:Aorta, Thoracic / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D001022:Aortic Valve Insufficiency / Q000601:surgery*; D001705:Bioprosthesis; D019917:Blood Vessel Prosthesis Implantation; D004338:Drug Combinations; D005557:Formaldehyde / Q000008:administration & dosage / Q000009:adverse effects*; D005780:Gelatin / Q000008:administration & dosage / Q000009:adverse effects*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012086:Reoperation; D012118:Resorcinols / Q000008:administration & dosage / Q000009:adverse effects*; D012422:Rupture, Spontaneous; D012850:Sinus of Valsalva / Q000187:drug effects* / Q000473:pathology; D017540:Tunica Media / Q000187:drug effects / Q000473:pathology
chemical_list: D004338:Drug Combinations; D012118:Resorcinols; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; D005557:Formaldehyde; D005780:Gelatin