title: Localization of a susceptibility gene for common forms of stroke to 5q12.
abstract: Stroke is one of the most complex diseases, with several subtypes, as well as secondary risk factors, such as hypertension, hyperlipidemia, and diabetes, which, in turn, have genetic and environmental risk factors of their own. Here, we report the results of a genomewide search for susceptibility genes for the common forms of stroke. We cross-matched a population-based list of patients with stroke in Iceland with an extensive computerized genealogy database clustering 476 patients with stroke within 179 extended pedigrees. Linkage to 5q12 was detected, and the LOD score at this locus meets the criteria for genomewide significance (multipoint allele-sharing LOD score of 4.40, P=3.9 x 10(-6)). A 20-cM region on 5q was physically and genetically mapped to obtain accurate marker order and intermarker distances. This locus on 5q12, which we have designated as "STRK1," does not correspond to known susceptibility loci for stroke or for its risk factors and represents the first mapping of a locus for common stroke.
authors.affiliation: deCODE Genetics, Reykjavik, Iceland.
authors.forename: Solveig
authors.initials: S
authors.lastname: Gretarsdottir
authors.forename: Sigurlaug
authors.initials: S
authors.lastname: Sveinbjörnsdottir
authors.forename: Hjörtur H
authors.initials: HH
authors.lastname: Jonsson
authors.forename: Finnbogi
authors.initials: F
authors.lastname: Jakobsson
authors.forename: Elisabet
authors.initials: E
authors.lastname: Einarsdottir
authors.forename: Uggi
authors.initials: U
authors.lastname: Agnarsson
authors.forename: Dana
authors.initials: D
authors.lastname: Shkolny
authors.forename: Gisli
authors.initials: G
authors.lastname: Einarsson
authors.forename: Herdis M
authors.initials: HM
authors.lastname: Gudjonsdottir
authors.forename: Einar M
authors.initials: EM
authors.lastname: Valdimarsson
authors.forename: Olafur B
authors.initials: OB
authors.lastname: Einarsson
authors.forename: Gudmundur
authors.initials: G
authors.lastname: Thorgeirsson
authors.forename: Radinka
authors.initials: R
authors.lastname: Hadzic
authors.forename: Sif
authors.initials: S
authors.lastname: Jonsdottir
authors.forename: Sigridur Th
authors.initials: ST
authors.lastname: Reynisdottir
authors.forename: Sigrun M
authors.initials: SM
authors.lastname: Bjarnadottir
authors.forename: Thorunn
authors.initials: T
authors.lastname: Gudmundsdottir
authors.forename: Gudrun J
authors.initials: GJ
authors.lastname: Gudlaugsdottir
authors.forename: Ramanjit
authors.initials: R
authors.lastname: Gill
authors.forename: Klaus
authors.initials: K
authors.lastname: Lindpaintner
authors.forename: Jesus
authors.initials: J
authors.lastname: Sainz
authors.forename: Helgi H
authors.initials: HH
authors.lastname: Hannesson
authors.forename: Gunnar Th
authors.initials: GT
authors.lastname: Sigurdsson
authors.forename: Michael L
authors.initials: ML
authors.lastname: Frigge
authors.forename: Augustine
authors.initials: A
authors.lastname: Kong
authors.forename: Vilmundur
authors.initials: V
authors.lastname: Gudnason
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Gulcher
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000235:genetics; D006973:Hypertension / Q000150:complications / Q000235:genetics; D007055:Iceland; D008126:Lod Score; D008297:Male; D010375:Pedigree; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000235:genetics*
chemical_list: D005819:Genetic Markers