title: The effect of four-week administration of amitriptyline on sleep bruxism. A double-blind crossover clinical study.
abstract: The purpose of this study was to evaluate the effect of a tricyclic antidepressant (amitriptyline) on nocturnal masseteric activity and duration of sleep in bruxists. Using a randomized, double blind, crossover design, ten females (mean age 39 yrs, +/- sd seven yrs) received active (amitriptyline 25 mg/night) and inactive (placebo 25 mg/night) medication, over a period of four weeks each. A portable EMG integrator recorded the nocturnal, unilateral, and cumulative myoelectrical activity (microV/min of sleep) of the masseter muscle during the fourth and eighth weeks of the study. The results showed that amitriptyline did not significantly decrease the mean EMG activity (df = 9, alpha = 0.05, paired-t = 0.892, p = 0.3964), nor did it significantly increase the duration of sleep (df = 9, alpha = 0.05, paired-t = 2.140, p = 0.061). The results of this study do not support the administration of 25 mg of amitriptyline per night over a period of four weeks for the management of sleep bruxism.
authors.affiliation: Department of Prosthodontics at the Louisiana State University Health Sciences Center, School of Dentistry, New Orleans 70119-2799, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Raigrodski
authors.forename: L V
authors.initials: LV
authors.lastname: Christensen
authors.forename: S E
authors.initials: SE
authors.lastname: Mohamed
authors.forename: D M
authors.initials: DM
authors.lastname: Gardiner
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000704:Analysis of Variance; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004576:Electromyography / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008406:Masseter Muscle / Q000187:drug effects; D016011:Normal Distribution; D010919:Placebos; D012890:Sleep / Q000187:drug effects; D020186:Sleep Bruxism / Q000188:drug therapy*; D013223:Statistics as Topic; D016896:Treatment Outcome
chemical_list: D000929:Antidepressive Agents, Tricyclic; D010919:Placebos; D000639:Amitriptyline