The effect of IFNgamma on the hepatocyte: cell cycle and apoptosis.
The inflammatory cytokine interferon gamma (IFNgamma) can cause cell cycle arrest and apoptosis in the hepatocyte. Primarily these processes are protective but in chronic liver disease oncogenic mutations may prosper. IFNgamma signalling is discussed showing how p53 is induced to cause cell cycle arrest. While caspases are are known to be responsible for IFNgamma induced apoptosis, how they are activated is unclear. Potential mechanisms are reviewed.
Tura
B J
BJ
Cell Injury and Apoptosis Group, (Department of Pathology), MRC Centre for Inflammation Research, University of Edinburgh Medical School, Edinburgh, UK.
Bunyan
K E
KE
Harrison
D J
DJ
D017209:Apoptosis / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology; D022781:Hepatocytes / Q000166:cytology*; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D007371:Interferon-gamma