title: Endoscopic injection sclerotherapy in the management of 2105 patients with esophageal varices.
abstract: BACKGROUND
  The objective of this study is to examine the overall clinical results of endoscopic injection sclerotherapy (EIS) for patients with esophageal varices in our institution.
  
  
  METHODS
  From January 1982 to May 2001, 2105 patients with esophageal varices were treated with EIS, which included prophylactic injections for patients with risky varices according to our criteria. Follow-up endoscopy was performed every 3 months, and recurrent varices were treated with additional EIS.
  
  
  RESULTS
  Acute variceal bleeding was controlled in 468 of 473 patients (98.9%). Esophageal varices were completely eradicated in 1757 of 2105 patients (83.5%) with 3.8 +/- 1.6 sessions of EIS. The cumulative recurrence rates were 32.2% at 5 years, 36.5% at 10 years, and 37.8% at 15 years. The cumulative nonbleeding rates were 92.3% at 5 years, 90.1% at 10 years, and 89.5% at 15 years. The survival rate of acute bleeders was significantly lower than for both elective and prophylactic cases (P <.05). The overall cumulative survival rate was 28.2% at 10 years.
  
  
  CONCLUSIONS
  EIS is the first choice of treatment for esophageal variceal bleeding, and rebleeding was shown to be well controlled in a long-term follow-up with endoscopy and additional EIS. The lower survival rate observed in acute bleeders may therefore justify the use of prophylactic EIS.
authors.affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Morimasa
authors.initials: M
authors.lastname: Tomikawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashizume
authors.forename: Keishi
authors.initials: K
authors.lastname: Okita
authors.forename: Seigo
authors.initials: S
authors.lastname: Kitano
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ohta
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Higashi
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Akahoshi
mesh_terms: D000208:Acute Disease; D000368:Aged; D016099:Endoscopy, Gastrointestinal; D004932:Esophageal and Gastric Varices / Q000401:mortality / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006471:Gastrointestinal Hemorrhage / Q000401:mortality / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D015911:Sclerotherapy; D015996:Survival Rate; D016896:Treatment Outcome