title: Comprehensive cytogenetic evaluation of a mature ovarian teratoma case.
abstract: Mature ovarian teratomas are benign ovarian germ cell tumors that usually present with a normal karyotype. There are very few reports describing chromosomal abnormalities in these tumors, none of which are recurrent. In this study we report on a mature teratoma case with clonal chromosomal alterations which include monosomies of chromosomes 6, 14, 16, and 21; trisomies of chromosomes 14 and 21; and deletions of Xq, 5p, 16p, and 17p. Comparative genomic hybridization evaluation of the sample revealed a normal profile. These findings are discussed together with the cytogenetic reports on other cases of ovarian teratomas described in the literature.
authors.affiliation: Departamento de Genética, Universidade Federal do Paraná, Caixa Postal 19071, CEP 81531-970, Curitiba, Paraná, Brazil.
authors.forename: Ana Teresa
authors.initials: AT
authors.lastname: Schmid-Braz
authors.forename: Luciane Regina
authors.initials: LR
authors.lastname: Cavalli
authors.forename: Déborah Afonso
authors.initials: DA
authors.lastname: Cornélio
authors.forename: Lismeri
authors.initials: L
authors.lastname: Wuicik
authors.forename: Enilze M S F
authors.initials: EM
authors.lastname: Ribeiro
authors.forename: Luiz F
authors.initials: LF
authors.lastname: Bleggi-Torres
authors.forename: Rubens Silveira
authors.initials: RS
authors.lastname: Lima
authors.forename: Cícero
authors.initials: C
authors.lastname: de Andrade Urban
authors.forename: Bassem R
authors.initials: BR
authors.lastname: Haddad
authors.forename: Iglenir João
authors.initials: IJ
authors.lastname: Cavalli
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D010051:Ovarian Neoplasms / Q000235:genetics*; D013724:Teratoma / Q000235:genetics*