title: Telomere lengths are characteristic in each human individual.
abstract: BACKGROUND
  A great deal of attention has been focused on telomeres in relation to cellular aging, immortality, and cancer. However, there is no simple link between telomeres and tissue turnover. We recently proposed a hypothesis that telomere shortening with aging and telomere lengths in different organs are characteristic for human individuals.
  
  
  METHODS
  To test this, telomere lengths were measured using DNA from cerebral cortex, myocardium, liver, renal cortex and spleen tissues obtained from human subjects ranging in age from neonates to centenarians.
  
  
  RESULTS
  Regression analyses demonstrated telomere reduction rates of 29-60 base pair (bp) per year in the liver, renal cortex and spleen, but no such decrease in the cerebral cortex and myocardium. Significant correlation was found between tissues within individuals, such as cerebral cortex versus (vs) myocardium, cerebral cortex vs liver, cerebral cortex vs renal cortex, myocardium vs liver, myocardium vs renal cortex, and liver vs renal cortex. In most cases, the longest telomeres were observed in the myocardium and the shortest in the liver or renal cortex.
  
  
  CONCLUSIONS
  Telomere lengths did not show clear correlation with tissue renewal times in vivo, but rather were characteristic for individuals.
authors.affiliation: Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173 0015, Japan. takubo@tmig.or.jp
authors.forename: Kaiyo
authors.initials: K
authors.lastname: Takubo
authors.forename: Naotaka
authors.initials: N
authors.lastname: Izumiyama-Shimomura
authors.forename: Naoko
authors.initials: N
authors.lastname: Honma
authors.forename: Motoji
authors.initials: M
authors.lastname: Sawabe
authors.forename: Tomio
authors.initials: T
authors.lastname: Arai
authors.forename: Motonobu
authors.initials: M
authors.lastname: Kato
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Oshimura
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Nakamura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015139:Blotting, Southern; D001921:Brain / Q000648:ultrastructure; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000032:analysis; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D007223:Infant; D007668:Kidney / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000648:ultrastructure; D012044:Regression Analysis; D016615:Telomere
chemical_list: D004247:DNA