Involvement of the serotonergic system in orexin-induced behavioral alterations in rats.
We have demonstrated involvement of the serotonergic system in orexin-induced behavioral responses in rats. Orexin-A and -B (hypocretin-1 and -2) significantly increased total locomotor activity when administered centrally. They also induced behavioral alterations; increasing grooming, face washing and wet dog shaking in rats. Haloperidol inhibited orexin-induced hyperlocomotion and these behavioral alterations. Serotonin antagonists, ritanserin and metergoline, did not attenuate orexin-induced hyperlocomotion but partly inhibited orexin-induced behavioral alterations. These results suggest that the dopaminergic system might be involved in orexin-induced hyperlocomotion, while both the serotonergic system as well as the dopaminergic system might be involved in orexin-induced behavioral responses.
Matsuzaki
Ichiyo
I
Department of Environmental Health, Institute of Community Medicine, University of Tsukuba, Ibaraki 305-8575, Tsukuba, Japan.
Sakurai
Takeshi
T
Kunii
Kaiko
K
Nakamura
Toshiaki
T
Yanagisawa
Masashi
M
Goto
Katsutoshi
K
D000818:Animals; D002352:Carrier Proteins / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D006120:Grooming / Q000187:drug effects / Q000502:physiology; D006220:Haloperidol / Q000494:pharmacology; D007276:Injections, Intraventricular / Q000379:methods; D047908:Intracellular Signaling Peptides and Proteins; D008124:Locomotion / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D009479:Neuropeptides / Q000494:pharmacology*; D000068797:Orexins; D051381:Rats; D017208:Rats, Wistar; D016713:Ritanserin / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology
D002352:Carrier Proteins; D018492:Dopamine Antagonists; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins; D012702:Serotonin Antagonists; D016713:Ritanserin; D008711:Metergoline; D012701:Serotonin; D006220:Haloperidol; D004298:Dopamine