title: Phytochemical and pharmacological analysis of Bauhinia microstachya (Raddi) Macbr. (Leguminosae).
abstract: This paper describes the isolation of four phytoconstituents from the leaves of Bauhinia microstachya, a Brazilian medicinal plant used in folk medicine for the treatment of several ailments. Based on spectroscopic evidence, these compounds were identified as methyl gallate (1), kaempferol 3-O-rhamnosyl (2), quercitrin (3) and myricitrin (4). The crude methanolic extract and two compounds (3 and 4) were tested as analgesic using the writhing test in mice. The extract and compound 3 caused potent and dose-related analgesic effects, confirming the popular use of this plant for the treatment dolorous processes.
authors.affiliation: Departamento de Química, Universidade Federal de Santa Catarina UFSC, Florianópolis, SC, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Meyre-Silva
authors.forename: R A
authors.initials: RA
authors.lastname: Yunes
authors.forename: F
authors.initials: F
authors.lastname: Delle Monache
authors.forename: A R
authors.initials: AR
authors.lastname: Santos
authors.forename: L O
authors.initials: LO
authors.lastname: Schmeling
authors.forename: V M
authors.initials: VM
authors.lastname: Gadotti
authors.forename: F
authors.initials: F
authors.lastname: Liz
authors.forename: V
authors.initials: V
authors.lastname: Cechinel-Filho
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001938:Brazil; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D044949:Kaempferols; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D044949:Kaempferols; C012526:quercitrin; C052082:methyl gallate; D005707:Gallic Acid; C006552:kaempferol; D011794:Quercetin