title: Apoptosis: a link between cancer genetics and chemotherapy.
abstract: Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.
authors.affiliation: Cancer Immunology Division, The Peter MacCallum Cancer Institute, Trescowthick Research Laboratories, Smorgon Family Building, St. Andrews Place, East Melbourne, 3002 Victoria, Australia. r.johnstone@pmci.unimelb.edu.au
authors.forename: Ricky W
authors.initials: RW
authors.lastname: Johnstone
authors.forename: Astrid A
authors.initials: AA
authors.lastname: Ruefli
authors.forename: Scott W
authors.initials: SW
authors.lastname: Lowe
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents