title: Antiinflammatory effect of heparin-coated circuits with leukocyte-depleting filters in coronary bypass surgery.
abstract: Cardiac surgery with cardiopulmonary bypass is associated with a systemic inflammatory response. We examined combined use of heparin coating of the cardiopulmonary bypass circuit and a leukocyte-depleting arterial line filter to reduce this response. Thirty patients were allocated randomly to equal groups with a conventional circuit and arterial line filter (C group), a heparin-coated circuit with a conventional filter (H group), or a heparin-coated circuit with a leukocyte-depleting arterial line filter (HF group). Cytokines and respiratory function were repeatedly measured perioperatively. Plasma interleukin (IL)-6 concentrations in the HF group were lower than in the C group immediately following bypass and operation, at 4 h, and 12 h (p < 0.05). Plasma IL-8 was lower in the HF group than in the C group at 4 h (p < 0.05). The respiratory index was lower immediately after bypass in the HF group than the C group (0.61 +/- 0.2 versus 1.05 +/- 0.4, p < 0.05). Heparin-coated circuits with leukocyte-depleting filters decrease inflammatory responses and improve pulmonary function during operation.
authors.affiliation: Department of Surgery II, Ehime University School of Medicine, Shigenobu, Ehime, Japan. ryoji@m.ehime-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Hamada
authors.forename: K
authors.initials: K
authors.lastname: Kawachi
authors.forename: T
authors.initials: T
authors.lastname: Nakata
authors.forename: T
authors.initials: T
authors.lastname: Kohtani
authors.forename: S
authors.initials: S
authors.lastname: Takano
authors.forename: N
authors.initials: N
authors.lastname: Tsunooka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002315:Cardiopulmonary Bypass; D020099:Coated Materials, Biocompatible; D001026:Coronary Artery Bypass; D005260:Female; D005374:Filtration; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D020099:Coated Materials, Biocompatible; D015850:Interleukin-6; D016209:Interleukin-8; D006493:Heparin