[Effects of theraphthal-Lio on hemostasis in experimental animals].
Teraphtal-Lio (Tph) exerted a toxic dose-dependent effect on the hemostatic system. Treatment of experimental animals with maximum tolerated and highly toxic doses was followed by acute DVS syndrome formation involving a hemophilic condition, soaring activated partial prothrombin time, absence of fibrinogen, sharp rise in fibrinogen degradation product and D-dimer matched by fall in thrombocyte count. No toxic influence on the hemostatic system was registered when Tph doses recommended for humans in the course of phase II clinical trials were administered to animals.
Madzhuga
A V
AV
N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.
Ermakova
N P
NP
Chlenova
E L
EL
Koniaeva
O N
ON
Somonova
O V
OV
Elizarova
A L
AL
Mikhaĭlova
L M
LM
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000633:toxicity*; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects / Q000633:toxicity*; D007275:Injections, Intravenous; D008297:Male; D051381:Rats
D000970:Antineoplastic Agents; D007211:Indoles; C403768:theraphthal