[The TRALI syndrome--a life-threatening transfusion reaction].
Transfusion related acute lung injury (TRALI) is a serious complication of blood transfusion, characterized by non-cardiogenic lung oedema. We describe a case of TRALI due to granulocyte-specific antibodies. The 58-year-old patient received 2 units of fresh frozen plasma following colon surgery and within 30 min the patient developed an acute respiratory distress syndrome. Granulocyte-specific antibodies were found in one of the transfused plasma of a female blood donor who most likely became immunized against granulocyte alloantigens during her three pregnancies.
Voss
J
J
Institut für Immunologie und Transfusionsmedizin, Ernst-Moritz-Arndt-Universität Greifswald, Diagnostikzentrum/Sauerbruchstrasse, 17487 Greifswald.
Westphal
K
K
Böhme
J
J
Bux
J
J
Greinacher
A
A
D000208:Acute Disease; D000906:Antibodies / Q000276:immunology; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007431:Intraoperative Complications / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011654:Pulmonary Edema / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D011859:Radiography; D012128:Respiratory Distress Syndrome / Q000503:physiopathology; D013577:Syndrome; D065227:Transfusion Reaction
D000906:Antibodies