Cytotoxic effect of Argentine medicinal plant extracts on human hepatocellular carcinoma cell line.
Methanolic extracts from Achyrocline satureioides (Dc.) Lam, Aristolochia macroura Gomez, Lithraea molleoides (Vell.) Engl., Schinus molle L., unlike those from Celtis spinosa Spreng, Chenopodium ambrosioides L., Petiveria alliacea L., and Plantago major L. showed cytotoxic activity against a human hepatocellular carcinoma cell line, Hep G2. Schinus molle L. was the most active (IC50=50+/-7 microg/ml). These results call for further studies of these extracts.
Ruffa
M J
MJ
Facultad de Farmacia y Bioquijmica, Catedra de Virologija, Universidad de Buenos Aires, Capital Federal, Argentina.
Ferraro
G
G
Wagner
M L
ML
Calcagno
M L
ML
Campos
R H
RH
Cavallaro
L
L
D027926:Anacardiaceae / Q000633:toxicity; D000970:Antineoplastic Agents / Q000633:toxicity*; D001118:Argentina; D030022:Aristolochia / Q000633:toxicity; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology*; D027462:Chenopodium / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D006131:Growth Inhibitors / Q000633:toxicity*; D006801:Humans; D010936:Plant Extracts / Q000633:toxicity; D018514:Plant Structures; D010943:Plantago / Q000633:toxicity; D010946:Plants, Medicinal / Q000633:toxicity*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D010936:Plant Extracts