The effect of nimesulide on the indomethacin- and ethanol-induced gastric ulcer in rats.
In the present study, we investigated the effects of nimesulide, indomethacin, naproxene, ibuprofen and diclofenac, at anti-inflammatory doses, on the rat gastric tissue (total number = 102). In addition, the effect of nimesulide at doses of 100, 300 and 500 mg kg(-1) on indomethacin-induced and ethanol-induced damage (ulcer) was examined. The potency of nimesulide was compared with that of ranitidine (at 150 mg kg(-1)). Results indicated that nimesulide did not produce any gastric damage. Additionally, it has a therapeutic effect on indomethacin- and ethanol-induced gastric lesions. Ulcer areas were measured in the rats given nonsteroidal anti-inflammatory drugs (NSAIDs). Nimesulide (at doses of 100, 300 and 500 mg kg(-1)) and ranitidine (at a dose of 150 mg kg(-1)) treated completely indomethacin-induced ulcer. The mean ulcer area was 21.9 +/- 8.9 mm(2)in the indomethacin-given control group. Nimesulide and ranitidine reduced the ethanol-induced gastric ulcer. The ulcer area was 114.3 +/- 10.3 mm(2) in the ethanol-given group and it was 4.5 +/- 4.8, 20.1 +/- 1.66, 15.16 +/- 4.05 mm(2) for nimesulide (at doses of 100, 300 and 500 mg kg(-1)), respectively, and 64.16 +/- 3.97 mm(2) for ranitidine.
Süleyman
Halis
H
Department of Pharmacology, Atatürk University, Medical Faculty, Erzurum, Turkey. suleyman@atauni.edu.tr
Akçay
Fatih
F
Altinkaynak
Konca
K
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects*; D007213:Indomethacin / Q000633:toxicity*; D008297:Male; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D013449:Sulfonamides / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D000431:Ethanol; D011899:Ranitidine; C012655:nimesulide; D007213:Indomethacin