title: Cytotoxic and antibacterial activity of 2-oxopurine derivatives.
abstract: Initial screening of the cytotoxic and antibacterial properties of 6-substituted 2-oxopurines and dihydro-2-oxopurines revealed that several compounds exhibited cytotoxicity against K-562 cells in the same range as the well known antileukemic drug 6-mercaptopurine. Most compounds were also tested for inhibitory effect on a Gram-positive bacterium, Lactobacillus casei, as well as the mycobacterium Mycobacterium tuberculosis. Generally the 2-oxopurines exhibited low antibacterial effect.
authors.affiliation: Department of Chemistry, University of Oslo, PO Box 1033, Blindern, 0315 Oslo, Norway.
authors.forename: Geir
authors.initials: G
authors.lastname: Andresen
authors.forename: Lise-Lotte
authors.initials: LL
authors.lastname: Gundersen
authors.forename: Jon
authors.initials: J
authors.lastname: Nissen-Meyer
authors.forename: Frode
authors.initials: F
authors.lastname: Rise
authors.forename: Bjørn
authors.initials: B
authors.lastname: Spilsberg
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D020014:K562 Cells / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011687:Purines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C475780:2-oxopurine; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D011687:Purines