Six year multicenter surveillance of invasive pneumococcal infections in children.
OBJECTIVE
Monitor clinical and microbiologic features including antimicrobial susceptibility of invasive pneumococcal infections among children.


METHODS
A 6-year (September, 1993, through August, 1999) prospective surveillance study of all invasive pneumococcal infections in children.


METHODS
Infants and children cared for at eight children's hospitals in the United States with culture-proved invasive pneumococcal infection.


RESULTS
During the 6-year period 2581 episodes of invasive pneumococcal infection occurred in 2498 children. Underlying conditions were present in 29% of the children. Of children without an underlying condition, 15% of the total infections occurred in those 25 to 60 months old. As the ages of the children advanced the proportion of cases classified as bacteremia declined, whereas the proportion classified as pneumonia increased. Also, as the ages of the children increased the proportion of isolates in serotypes/serogroups 1, 3 and 23 increased. whereas the proportion for serotype 14 diminished. During the 6 years of the study, there was a significant increase in the percentage of isolates intermediate or resistant to penicillin (P < 0.000001) or intermediate to ceftriaxone (P < 0.002). By the sixth year of the study, 37 and 11% of the isolates were nonsusceptible to penicillin or ceftriaxone, respectively. Antibiotic use in the 30 days before diagnosis of systemic pneumococcal infection occurred in 30 to 35% of the children for each of the 6 years. The overall case-fatality rate for children with systemic pneumococcal infection was 1.56%. Mortality was greatest in children >60 months old and in those with underlying conditions; mortality was not related to antibiotic susceptibility.


CONCLUSIONS
The percentage of pneumococcal isolates recovered from children with systemic infection which were intermediate for penicillin or ceftriaxone or resistant to penicillin increased steadily during the 6-year period. There was also a trend toward increasing rates of resistance to ceftriaxone. The age and serogroup/serotype distributions of our patients support the recommendations to consider administration of the seven valent pneumococcal conjugate vaccine for all children 24 to 59 months old, with special consideration for selected groups.
Kaplan
Sheldon L
SL
Pediatric Infectious Diseases Sections, Baylor College of Medicine, Houston, TX , USA. skaplan@bcm.tmc.edu
Mason
Edward O
EO
Wald
EllenR
E
Tan
Tina Q
TQ
Schutze
Gordon E
GE
Bradley
John S
JS
Givner
Laurence B
LB
Kim
Kwang Sik
KS
Yogev
Ram
R
Barson
William J
WJ
D000367:Age Factors; D002443:Ceftriaxone / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009026:Mortality; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D011159:Population Surveillance; D011446:Prospective Studies; D012307:Risk Factors; D012698:Serologic Tests
D002511:Cephalosporins; D002443:Ceftriaxone