title: Structure and function of IRF-7.
abstract: Interferon (IFN) regulatory factors (IRF) are a family of transcription factors with multiple functions. IRF-7 was initially cloned within the biologic context of Epstein-Barr virus (EBV) latency and discovered to have an intimate relation with the EBV primary oncogenic protein, latent membrane protein-1 (LMP-1). EBV regulates and uses IRF-7 as a secondary mediator for several target genes involved in latency and immune regulation. Other than its functions in EBV latency, IRF-7 has been identified as one of the major players in virally induced IFN production that is central to innate immunity. Thus, IRF-7 plays important roles in a variety of biologic systems.
authors.affiliation: Nebraska Center for Virology, UNL Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA. lzhang@unlnotes.unl.edu
authors.forename: Luwen
authors.initials: L
authors.lastname: Zhang
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Pagano
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000378:metabolism; D002880:Chromosomes, Human, Pair 11; D016384:Consensus Sequence; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D004854:Herpesvirus 4, Human / Q000502:physiology; D006801:Humans; D050839:Interferon Regulatory Factor-7; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D014157:Transcription Factors / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D015533:Transcriptional Activation; D017735:Virus Latency
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; C494234:IRF7 protein, human; D050839:Interferon Regulatory Factor-7; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; C484380:PDLIM7 protein, human; D014157:Transcription Factors