title: Skylab experiment results: hematology studies.
abstract: These studies were designed and coordinated to evaluate specific aspects of man's immunologic and hematologic systems which might be altered by or respond to the space flight environment. The biochemical functions investigated included cytogenetic damage to blood cells, immune resistance to disease, regulation of plasma and red cell volumes, metabolic processes of the red blood cell, and physical chemical aspects of red blood cell functions. Only minor changes were observed in the functional capacity of erythrocytes as determined by measuring the concentrations of selected intracellular enzymes and metabolites. Tests of red cell osmotic regulation indicated some elevation in the activity of the metabolic dependent Na-K pump, with no significant alterations in the cellular Na and K concentrations or osmotic fragility. A transient shift in red cell specific-gravity profile was observed on recovery, possibly related to changes in cellular water content. Measurements of hemoconcentration (hematocrit, hemoglobin concentration, red cell count) indicated significant fluctuations postflight, reflecting observed changes in red cell mass and plasma volume. There was no apparent reticulocytosis during the 18 days following the first manned Skylab mission in spite of a significant loss in red cell mass. However, the reticulocyte count and index did increase significantly 5 to 7 days after completion of the second, longer duration, flight. There were no significant changes in either the while blood cell count or differential. However, the capacity of lymphocytes to respond to an in vitro mitogenic challenge was repressed postflight, and appeared to be related to mission duration. The cause of this repression is unknown at this time. Only minor differences were observed in plasma protein patterns. In the second mission there were changes in the proteins involved in the coagulation process which suggested a hypercoagulative condition.
authors.affiliation: Cellular Analytical Laboratory, Johnson Space Center, Houston, Texas, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Kimzey
authors.forename: S E
authors.initials: SE
authors.lastname: Ritzmann
authors.forename: C E
authors.initials: CE
authors.lastname: Mengel
authors.forename: C L
authors.initials: CL
authors.lastname: Fischer
mesh_terms: D000337:Aerospace Medicine; D001798:Blood Proteins / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D004912:Erythrocytes / Q000378:metabolism / Q000502:physiology*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007109:Immunity / Q000502:physiology*; D008213:Lymphocyte Activation / Q000502:physiology; D008214:Lymphocytes / Q000378:metabolism / Q000502:physiology*; D008297:Male; D012313:RNA / Q000096:biosynthesis; D012156:Reticulocytes; D013026:Space Flight; D014893:Weightlessness
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins; D012313:RNA; D004247:DNA