title: Development and evaluation of matrix and two layered sustained release suppositories of theophylline.
abstract: Theophylline loaded conventional suppositories, sustained release matrix suppositories and sustained release two layered suppositories were prepared using polyethylene glycol 4000 and eudragit RS-100 and their characteristics were evaluated both in-vitro and in-vivo. In comparison to conventional suppositories, the release of the drug from sustained release matrix suppositories was gradual and extended over a period of time. On the other hand two layered suppositories produced an initial quick release followed by extended release of the drug. The in-vivo results were found to correlate with the in-vitro results.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
authors.forename: S
authors.initials: S
authors.lastname: Maity
authors.forename: B
authors.initials: B
authors.lastname: Sa
authors.forename: A K
authors.initials: AK
authors.lastname: Bandyopadhyay
mesh_terms: D000818:Animals; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations; D005079:Excipients; D008297:Male; D011817:Rabbits; D012995:Solubility; D013488:Suppositories; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D005079:Excipients; D013488:Suppositories; D013806:Theophylline