Sibling rivalry in the E2F family.
The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this 'push-me-pull-you' regulation, and what are its biological consequences?
Trimarchi
Jeffrey M
JM
Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Lees
Jacqueline A
JA
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000502:physiology; D002454:Cell Differentiation; D002455:Cell Division; D002843:Chromatin / Q000378:metabolism; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D050701:E2F6 Transcription Factor; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008957:Models, Genetic; D009369:Neoplasms / Q000209:etiology; D017434:Protein Structure, Tertiary; D016160:Retinoblastoma Protein / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D018797:Cell Cycle Proteins; D002843:Chromatin; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D050701:E2F6 Transcription Factor; C491744:E2F6 protein, human; C111236:E2f6 protein, mouse; D016160:Retinoblastoma Protein; D014157:Transcription Factors