title: Acute toxicity, mutagenicity, and estrogenicity of bisphenol-A and other bisphenols.
abstract: Although abundant data are available on the toxicity of bisphenol-A (2,2-bis (4-hydroxydiphenyl)propane; BPA), little is known about the toxicities of the structurally similar compounds, namely bisphenols (BPs). A variety of BPs were examined for their acute toxicity against Daphnia magna, mutagenicity, and estrogenic activity using the Daphtoxkit (Creasel Ltd.), the umu test system, and the yeast two-hybrid system, respectively, in comparison with BPA. BPA was moderately toxic to D. magna (48-h EC50 was 10 mg/l) according to the current U.S. EPA acute toxicity evaluation standard, and it was weakly estrogenic with 5 orders of magnitude lower activity than that of the natural estrogen 17 beta-estradiol in the yeast screen, while no mutagenicity was observed. All seven BPs tested here showed moderate to slight acute toxicity, no mutagenicity, and weak estrogenic activity as well as BPA. Some of the BPs showed considerably higher estrogenic activity than BPA, and others exhibited much lower activity. Among the tested BPs, two compounds, i.e., bisphenol-S (bis(4-hydroxydiphenyl)sulfone) and bis(4-hydroxyphenyl)sulfide, have never been reported for their estrogenic activity previously.
authors.affiliation: Department of Environmental Engineering, Graduate School of Engineering, Osaka University, 2-1, Yamada-Oka, Suita, Osaka 565-0871, Japan.
authors.forename: Min-Yu
authors.initials: MY
authors.lastname: Chen
authors.forename: Michihiko
authors.initials: M
authors.lastname: Ike
authors.forename: Masanori
authors.initials: M
authors.lastname: Fujita
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D004249:DNA Damage; D003621:Daphnia; D004968:Estrogens, Non-Steroidal / Q000633:toxicity*; D005786:Gene Expression Regulation / Q000187:drug effects; D009152:Mutagenicity Tests; D010636:Phenols / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D018675:Toxicity Tests; D015003:Yeasts; D001616:beta-Galactosidase / Q000096:biosynthesis; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D001616:beta-Galactosidase; C006780:bisphenol A; D000098826:Bisphenol A Compounds