Sequence variation in a newly identified HLA-B35-restricted epitope in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes.
Here, we describe a new HLA-B*3501-restricted cytotoxic T lymphocyte (CTL) epitope in the influenza A virus (H3N2) nucleoprotein, which was found to exhibit a high degree of variation at nonanchor residues. The influenza virus variants emerged in chronological order, and CTLs directed against old variants failed to recognize more recent strains of influenza A virus, indicating an escape from CTL immunity.
Boon
A C M
AC
Institute of Virology, Erasmus University Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.
de Mutsert
G
G
Graus
Y M F
YM
Fouchier
R A M
RA
Sintnicolaas
K
K
Osterhaus
A D M E
AD
Rimmelzwaan
G F
GF
D000595:Amino Acid Sequence; D000940:Antigenic Variation; D000939:Epitopes / Q000276:immunology*; D015797:HLA-B35 Antigen / Q000378:metabolism*; D006801:Humans; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology*; D008969:Molecular Sequence Data; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins / Q000235:genetics* / Q000276:immunology*; D016601:RNA-Binding Proteins; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014758:Viral Core Proteins / Q000235:genetics* / Q000276:immunology*
D000939:Epitopes; D015797:HLA-B35 Antigen; C048842:NP protein, Influenza A virus; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D016601:RNA-Binding Proteins; D014758:Viral Core Proteins