[Preclinical toxicological study of theraphthal-Lio and binary catalytic system "theraphthal-Lio+ascorbic acid"].
Pre-clinical toxicologic studies were conducted of a new drug teraphtal-Lio (TPh) and a teraphtal-Lio + ascorbic acid (TPh + AA) catalytic system recommended for binary catalytic therapy of malignant tumors. Quantitative criteria for "acute" and "chronic" toxicity of TPh and TPh + AA were established, which describe their toxic effects in single or multiple application. The coefficient of specific sensitivity and cumulation index for TPh and TPh + AA were determined. The toxicodynamic characteristics of TPh and TPh + AA were investigated. The results were used to prognose pulmonary, cardio-vascular, hemato- and hepatotoxic as well as hemodynamic and ophthalmologic disorders and functional changes in the central nervous system involved in clinical use of TPh and TPh + AA.
Mikhaĭlova
L M
LM
N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.
Koniaeva
O N
ON
Chlenova
E L
EL
Merkulova
I B
IB
Ermakova
N P
NP
Gavrilova
T N
TN
Sergeev
A A
AA
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects / Q000633:toxicity*; D008297:Male; D051379:Mice; D011379:Prognosis; D051381:Rats; D013997:Time Factors
D000970:Antineoplastic Agents; D007211:Indoles; C403768:theraphthal