title: Contrast-enhanced power Doppler sonography of the intestinal wall in the differentiation of hypervascularized and hypovascularized intestinal obstructions in patients with Crohn's disease.
abstract: OBJECTIVE
  To use power Doppler sonography to quantify the vascularization in the area of stenosed bowel segments in patients with Crohn's disease and to draw conclusions from these findings with regard to the development of these stenoses.
  
  
  METHODS
  The study collective included 11 patients with confirmed Crohn's disease and sonographically visualized stenoses of the small bowel together with intermittent abdominal cramping as a clinical correlate. Power mode examination was repeated after application of a sonographic signal-enhancing agent. Semiquantitative evaluation based on the sonographically indicated degree of vascularization led to the presumptive diagnosis of either inflammatory or cicatricial intestinal obstruction. Sonographic diagnoses were compared with the findings of surgery and subsequent histologic examination or with patients' clinical responses to conservative therapy.
  
  
  RESULTS
  Nine of 11 patients underwent surgery within 1 year of examination. All 3 cases in which sonography had facilitated the diagnosis of cicatricial stenosis were confirmed at postoperative histologic examination; similarly, the surgical and histologic findings in the other 6 patients confirmed the sonographic diagnosis of inflammatory stenosis.
  
  
  CONCLUSIONS
  Power Doppler sonography in combination with the use of a signal-enhancing agent appears to be effective in the recognition of predominantly cicatricial stenoses in patients with Crohn's disease.
authors.affiliation: Department of Internal Medicine I, University of Ulm, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kratzer
authors.forename: Christian
authors.initials: C
authors.lastname: von Tirpitz
authors.forename: Richard
authors.initials: R
authors.lastname: Mason
authors.forename: Max
authors.initials: M
authors.lastname: Reinshagen
authors.forename: Guido
authors.initials: G
authors.lastname: Adler
authors.forename: Peter
authors.initials: P
authors.lastname: Möller
authors.forename: Andrea
authors.initials: A
authors.lastname: Rieber
authors.forename: Volker
authors.initials: V
authors.lastname: Kächele
mesh_terms: D000328:Adult; D003287:Contrast Media; D003424:Crohn Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000000981:diagnostic imaging*; D007421:Intestine, Small / Q000000981:diagnostic imaging; D008297:Male; D011134:Polysaccharides; D018608:Ultrasonography, Doppler
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508