title: A new antibacterial diterpene from the roots of Salvia caespitosa.
abstract: From the roots of Saliva caespitosa Montbret and Aucher ex. Bentham a new diterpene 6beta-hydroxyisopimaric acid (1) has been isolated together with four known diterpenes, one new triterpenoid, 3-acetylvergatic acid (2), as well as five known triterpenoids, two steroids and a flavone. The structures of the compounds were established by spectroscopic analyses. The isolated compounds were tested against standard bacterial strains. Only the new diterpene, 6beta-hydroxyisopimaric acid has strong activity (MIC 9 microg/ml) against S. aureus and (MIC 18 microg/ml) against S. epidermidis as well as against B. subtilis (MIC 9 microg/ml).
authors.affiliation: Department of Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Ulubelen
authors.forename: S
authors.initials: S
authors.lastname: Oksüz
authors.forename: G
authors.initials: G
authors.lastname: Topcu
authors.forename: A C
authors.initials: AC
authors.lastname: Gören
authors.forename: C
authors.initials: C
authors.lastname: Bozok-Johansson
authors.forename: C
authors.initials: C
authors.lastname: Celik
authors.forename: G
authors.initials: G
authors.lastname: Kökdil
authors.forename: W
authors.initials: W
authors.lastname: Voelter
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D027544:Salvia / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014421:Turkey
chemical_list: C447264:3-acetylvergatic acid; C447263:6-hydroxyisopimaric acid; D000900:Anti-Bacterial Agents; D004224:Diterpenes; D005419:Flavonoids; D013256:Steroids; D014315:Triterpenes; C447265:vergatic acid