Prolonged survival after experimental paraquat intoxication: role of alternative antioxidants.
Since paraquat poisoning causes multiorgan damage through the generation of several redox products, the usual therapy includes antioxidative drugs, such as N-acetylcysteine. We investigated whether selected antioxidative drugs can improve survival from acute paraquat toxicity. Forty-eight male 2-3-mo-old Wistar rats were divided into 4 groups receiving paraquat dichloride in a single injection (11 mg/kg bw ip) I h before the administration of normal saline (control ip), S-carboxymethylcysteine (600 mg/kg bw po), propofol (100 mg/kg bw ip) or trimetazidine (10 mg/kg bw po). Animals were observed for 7 d. The median survival time in the control group was 3 d whereas it was 4 (p = 0.15), 4.5 (p < 0.05) or 5 (p < 0.05) d for the trimetazidine, S-carboxymethylcysteine or propofol-treated groups, respectively.
Lugo-Vallín
Nelly del Valle
Ndel V
Sección de Farmacología, Universidad Centroccidental Lisandro Alvarado, Barquisimeto, Estado Lara, Venezuela.
Pascuzzo-Lima
Carmine
C
Maradei-Irastorza
Idania
I
Ramírez-Sánchez
Manuel
M
Sosa-Sequera
Miriam
M
Aguero-Penã
Rafael
R
Granado-Duque
Angel
A
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002233:Carbocysteine / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006540:Herbicides / Q000633:toxicity*; D008297:Male; D015742:Propofol / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D015996:Survival Rate; D014292:Trimetazidine / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000627:therapeutic use
D000975:Antioxidants; D016166:Free Radical Scavengers; D006540:Herbicides; D014665:Vasodilator Agents; D002233:Carbocysteine; D014292:Trimetazidine; D015742:Propofol