title: Familial oligoasthenoteratozoospermia: evidence of autosomal dominant inheritance with sex-limited expression.
abstract: OBJECTIVE
  To report the familial occurrence of severe oligoasthenoteratozoospermia in a man and five male relatives related through their mothers.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University medical center.
  
  
  METHODS
  Six affected family members.
  
  
  METHODS
  Blood and semen samples were collected from all affected males and some of their healthy male relatives. Pedigree analysis and exclusion of X-linked disorder were done.
  
  
  RESULTS
  Analysis suggested that familial nonsyndromic male factor infertility was present.
  
  
  CONCLUSIONS
  The family described in this report suggests the existence of an autosomal dominant trait of male infertility with sex-limited expression.
authors.affiliation: Department of Human Genetics, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands. j.tuerlings@antrg.azn.nl
authors.forename: Joep H A M
authors.initials: JH
authors.lastname: Tuerlings
authors.forename: Ron J T
authors.initials: RJ
authors.lastname: van Golde
authors.forename: Astrid R
authors.initials: AR
authors.lastname: Oudakker
authors.forename: Helger G
authors.initials: HG
authors.lastname: Yntema
authors.forename: Jan A M
authors.initials: JA
authors.lastname: Kremer
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000235:genetics*; D010375:Pedigree