[The influence of side-to-side portacaval shunt plus enhancement of perfusion of hepatic artery on cirrhotic liver: an experimental study].
OBJECTIVE
To for improving the perfusion of liver, we designed an operation of portacaval shunt (PCS) plus enhancement of perfusion of hepatic artery (EPHA).


METHODS
48 wistar rats were divided into 4 groups randomly. group I (normal control), group II (liver cirrhotic control), group III (PCS on liver cirrhosis), and group IV (PCS + EPHA on liver cirrhosis). The EPHA was performed by the ligation of the left gastric and splenic artery. Liver function tests, liver biopsy, and nuclide hepatobiliary dynamic imaging (NHDI) were performed on the 2nd week and the 6th month after operation.


RESULTS
In NHDI, the peak time was short (P < 0.05) and the excretive rate was high (P < 0.01). The liver function and the proliferative degree of the fibrotic tissue of the liver were perfected significantly (P < 0.05) in the group IV compared with the group III after operation.


CONCLUSIONS
PCS + EPHA can increase the perfusion of the hepatic artery, maintain the liver function and delay liver cirrhosis, and overcome the side effects of PCS. It is a new surgical technique in treating portal hypertension.
Weng
Y
Y
Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050.
Wang
Y
Y
Xue
J
J
Zhang
Z
Z
Zhou
Y
Y
Chen
D
D
Li
C
C
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D006499:Hepatic Artery / Q000503:physiopathology*; D006975:Hypertension, Portal / Q000150:complications / Q000601:surgery*; D008099:Liver / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000150:complications / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D010477:Perfusion; D011167:Portacaval Shunt, Surgical / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
D000410:Alanine Transaminase