Synthesis of 2,3-disubstituted indole using palladium(II)-catalyzed cyclization with alkenylation reaction.
The reaction of ethyl 2-ethynylphenylcarbamate derivative with alkenes in the presence of a palladium(II) catalyst, copper dichloride and tetrabutylammonium fluoride (TBAF) produced 2-substituted 3-ethenylindoles during refluxing. The intramolecular cyclization reaction of ethyl 2-ethynylphenylcarbamates, which have an ethenyl part in the ethynyl group, was also used to produce carbazole derivatives.
Yasuhara
Akito
A
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. yasuhara@mail.pharm.tohoku.ac.jp
Takeda
Yousuke
Y
Suzuki
Naoyuki
N
Sakamoto
Takao
T
D000475:Alkenes; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis*; D010165:Palladium / Q000494:pharmacology*
D000475:Alkenes; D007211:Indoles; D010165:Palladium