In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii.
The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani-infected mice but was less effective against T. gondii-infected mice.
Yardley
Vanessa
V
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom.
Khan
Anis A
AA
Martin
Michael B
MB
Slifer
Teri R
TR
Araujo
Fausto G
FG
Moreno
Silvia N J
SN
Docampo
Roberto
R
Croft
Simon L
SL
Oldfield
Eric
E
D000284:Administration, Oral; D019386:Alendronate / Q000494:pharmacology; D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D006224:Cricetinae; D004164:Diphosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D051228:Geranyltranstransferase; D007274:Injections, Intraperitoneal; D007893:Leishmania donovani / Q000187:drug effects* / Q000201:enzymology*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000469:parasitology*; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D011355:Prodrugs / Q000494:pharmacology; D016019:Survival Analysis; D014122:Toxoplasma / Q000187:drug effects* / Q000201:enzymology*; D014124:Toxoplasmosis, Animal / Q000188:drug therapy* / Q000469:parasitology*
D004164:Diphosphonates; D004791:Enzyme Inhibitors; D011355:Prodrugs; D019883:Alkyl and Aryl Transferases; D051228:Geranyltranstransferase; D019386:Alendronate