Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase.
Arenz
C
C
Institut für Organische Chemie, Universität Karlsruhe, Richard-Willstätter-Allee 2, 76128 Karlsruhe, Germany.
Thutewohl
M
M
Block
O
O
Waldmann
H
H
Altenbach
H J
HJ
Giannis
A
A
D019883:Alkyl and Aryl Transferases / Q000378:metabolism; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007700:Kinetics; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D011090:Polyenes / Q000138:chemical synthesis / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides; D051381:Rats; D015398:Signal Transduction; D013108:Sphingomyelin Phosphodiesterase / Q000037:antagonists & inhibitors* / Q000302:isolation & purification
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004791:Enzyme Inhibitors; D011090:Polyenes; D053284:Polyunsaturated Alkamides; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase; D013108:Sphingomyelin Phosphodiesterase; C054474:manumycin