title: Resistance of succinic acid dimethyl ester insulinotropic action to exendin (9-39) amide.
abstract: Exendin (9-39) amide (Ex [9-39]) was recently proposed for use in the treatment of alimentary or reactive hypoglycaemia. It was indeed found to antagonise the insulinotropic action of GLP-1 in rats infused with the dimethyl ester of succinic acid (SAD). We have now investigated whether, under comparable experimental conditions, Ex (9-39) also opposes the insulin-releasing action of SAD itself. Since this was not the case, Ex (9-39) could be safely used to abolish the incretin effect of GLP-1 without interfering with the control of insulin secretion by circulating nutrients.
authors.affiliation: Fundación Jiménez Diaz, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Cancelas
authors.forename: J A
authors.initials: JA
authors.lastname: García-Martínez
authors.forename: M L
authors.initials: ML
authors.lastname: Villanueva-Peñacarrillo
authors.forename: I
authors.initials: I
authors.lastname: Valverde
authors.forename: W J
authors.initials: WJ
authors.lastname: Malaisse
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013386:Succinates / Q000037:antagonists & inhibitors*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010446:Peptide Fragments; D013386:Succinates; C083773:exendin (9-39); C056451:dimethyl succinate