title: Decrease of the electroacupuncture-induced analgesic effects in nuclear factor-kappa B1 knockout mice.
abstract: To investigate the involvement of nuclear factor kappa B1 (NF-kappaB1; p50/p105) in electroacupuncture (EA)-induced analgesia, 2 and 100 Hz EA stimulations were applied at acupoint ST36 (Zusanli) in NF-kappaB1 knockout mice. EA was performed for 30 min and tail-flick latencies (TFLs) were evaluated every 15 min for 1 h. Wild-type mice displayed a 63.3% increase in TFLs compared to baseline after 2 Hz EA, whereas NF-kappaB1+/- mice exhibited a 41.8% increase and NF-kappaB1-/- mice showed only a 3.9% increase of TFLs. The TFLs of 100 Hz EA showed similar trends: a 72.6% increase of TFLs in wild-type, a 38.6% increase in NF-kappaB1+/- and a 9.3% increase in NF-kappaB1-/- mice. The present findings suggest that NF-kappaB1 may play a crucial role in both low and high frequency EA-induced analgesic effects.
authors.affiliation: Research Group of Pain and Neuroscience, Kyung Hee University, Hoegidong, Dongdaemoongu, Seoul, South Korea.
authors.forename: Hi-Joon
authors.initials: HJ
authors.lastname: Park
authors.forename: Hyang-Sook
authors.initials: HS
authors.lastname: Lee
authors.forename: Hye-Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Yeong-Min
authors.initials: YM
authors.lastname: Yoo
authors.forename: Hee Jae
authors.initials: HJ
authors.lastname: Lee
authors.forename: Soon Ae
authors.initials: SA
authors.lastname: Kim
authors.forename: Kanghyun
authors.initials: K
authors.lastname: Leem
authors.forename: Ho-Chul
authors.initials: HC
authors.lastname: Kim
authors.forename: Jung-Chul
authors.initials: JC
authors.lastname: Seo
authors.forename: Ee-Hwa
authors.initials: EH
authors.lastname: Kim
authors.forename: Sabina
authors.initials: S
authors.lastname: Lim
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000698:Analgesia; D000818:Animals; D015671:Electroacupuncture; D005260:Female; D008297:Male; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics; D016328:NF-kappa B / Q000235:genetics / Q000502:physiology*; D010146:Pain / Q000503:physiopathology; D010147:Pain Measurement; D020033:Protein Isoforms / Q000235:genetics / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013623:Tail / Q000503:physiopathology
chemical_list: D016328:NF-kappa B; D020033:Protein Isoforms