title: Determination of Three Acetylator Phenotypes in a Mexican Population Using Sulfamethazine Metabolic Ratio.
abstract: Eighty-six Mexican young healthy volunteers received a 500-mg oral sulfamethazine dose. Urine was collected 0--6 h after medication and acetylated, and unchanged sulfamethazine were determined by the Bratton--Marshall method. The frequency distribution of acetylated/unchanged sulfamethazine, determined by probit analysis, appeared to be trimodal, allowing the discrimination of three acetylator phenotypes. The frequencies of rapid, intermediate, and slow acetylators were 28%, 42%, and 30% respectively, being consistent with the Hardy-Weinberg law.
authors.affiliation: Sección de Terapéutica Experimental, Departamento de Farmacologia y Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México, D.F., Mexico.
authors.forename: G.
authors.initials: G
authors.lastname: Castañeda-Hernández
authors.forename: A.
authors.initials: A
authors.lastname: Falcón-Neri
authors.forename: A.
authors.initials: A
authors.lastname: Herrera-Abarca
authors.forename: J. E.
authors.initials: JE
authors.lastname: Herrera
authors.forename: F. J.
authors.initials: FJ
authors.lastname: Flores-Murrieta