[Changes of interleukin-2 and soluble interleukin-2 receptor serum level and multiple organ dysfunction syndrome in severely traumatic patients].
OBJECTIVE
To evaluate the role in the changes of interleukin-2 (IL-2) and soluble interleukin-2R (sIL-2R) serum level in the mechanism of post-traumatic multiple organ dysfunction syndrome (MODS).


METHODS
59 severe traumatic patients were divided into MODS group (n = 24) and non-MODS group (n = 35) according to the occurrence of MODS after trauma. The changes in IL-2 and sIL-2R serum level were observed by enzyme linked immunoabsorbed assay (ELISA). Sera from 30 healthy individuals were used as normal controls.


RESULTS
The serum level of sIL-2R was increased and that of IL-2 decreased in 59 traumatic patients. These changes were more marked in the MODS group than in non-MODS group (p < 0.05).


CONCLUSIONS
The changes in IL-2 and sIL-2R serum level after trauma might participate in the mechanism of post-traumatic MODS.
He
Z
Z
Hainan Provincial People's Hospital, Haikou 570311.
Wang
S
S
Su
Z
Z
Huang
Y
Y
Yang
J
J
D000293:Adolescent; D000328:Adult; D016638:Critical Illness; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology*; D015375:Receptors, Interleukin-2 / Q000097:blood*; D014947:Wounds and Injuries / Q000097:blood* / Q000150:complications
D007376:Interleukin-2; D015375:Receptors, Interleukin-2