Studies on DNA cleavage by cytotoxic pyrrole alkaloids reveal the distinctly different behavior of roseophilin and prodigiosin derivatives.
Fürstner
A
A
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim/Ruhr, Germany. fuerstner@mpi.muelheim.mpg.de
Grabowski
E J
EJ
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D004587:Electrophoresis, Agar Gel; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000494:pharmacology; D011353:Prodigiosin / Q000737:chemistry* / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D006575:Heterocyclic Compounds, 3-Ring; D011758:Pyrroles; C408872:roseophilin; D004247:DNA; D011353:Prodigiosin