title: Concentration profile of mRNA of kinine B1 and B2 receptors in the evaluation of colon pathologies.
abstract: Colon pathologies involve the activation of a number of inflammation mediators: cytokines, prostanoids and kinines. The expression patterns of the genes associated with their activation may provide a very sensitive marker of the physiological condition of the cells. This paper demonstrates certain statistically significant differences (p = 0.008) between the expression patterns of kinine B1 and B2 receptor encoding genes for colitis ulcerosa and a control group. The ratio of kinine B1/B2 concentrations changes significantly, on the average from 1.3 for a tissue assessed as healthy to 6.6 for colitis ulcerosa.
authors.affiliation: Department of Molecular Biology, Biochemistry and Biopharmacy, Medical University of Silesia, Katowice, Poland. umazurek@farmant.slam.katowice.pl
authors.forename: U
authors.initials: U
authors.lastname: Mazurek
authors.forename: E
authors.initials: E
authors.lastname: Pastucha
authors.forename: J
authors.initials: J
authors.lastname: Orchel
authors.forename: G
authors.initials: G
authors.lastname: Bierzyńska-Macyszyn
authors.forename: K
authors.initials: K
authors.lastname: Cholewa
authors.forename: A
authors.initials: A
authors.lastname: Stadnicki
authors.forename: T
authors.initials: T
authors.lastname: Wilczok
mesh_terms: D003093:Colitis, Ulcerative / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D043783:Receptor, Bradykinin B1; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin / Q000235:genetics*; D019914:Taq Polymerase
chemical_list: D012333:RNA, Messenger; D043783:Receptor, Bradykinin B1; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin; D019914:Taq Polymerase