Linkage disequilibrium of HLA-A11 and A1 with one of the polymorphisms of the gamma-aminobutyric acid receptor type B.
The gamma-aminobutyric acid receptor type B 1 (GABA(B) R1) is located approximately at 200 kb telomeric to HLA-A on chromosome 6. It has 11 single-nucleotide polymorphisms (SNPs). We studied the most common of its SNPs (T1974C) in a panel of 118 normal Caucasians from New England and 161 epileptic patients of Caucasian ancestry residing in USA. The frequency of the polymorphism did not differ between patients and controls. Here, we report that the allele C of this SNP in the GABA(B) R1 gene is in linkage disequilibrium with HLA-A11 (P<0.00001) and to a lesser extent with HLA-A1 (P<0.01).
Anaya
M
M
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachussetts 02115, USA.
Romero
T
T
Sofia
R D
RD
Yunis
E J
EJ
D000483:Alleles; D004827:Epilepsy / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics*; D015788:HLA-A1 Antigen / Q000235:genetics*; D059870:HLA-A11 Antigen; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D018080:Receptors, GABA-B / Q000235:genetics*; D044465:White People / Q000235:genetics
D015234:HLA-A Antigens; D015788:HLA-A1 Antigen; D059870:HLA-A11 Antigen; D018080:Receptors, GABA-B