[Acoustic densitometry for quantification of renal allografts microcirculation and microstructure].
OBJECTIVE
To establish a new method for observing renal allografts microcirculation and microstructure with acoustic densitometry (integrated backscatter, contrast, second harmonics).


METHODS
27 patients with renal allografts were investigated by Doppler, IBS, contrast and second harmonics. Renal allografts failed age in 5 patients 20-61 years. Intravenous injection of SHU-508A was given, compared with pre-injection by quantitative assessment of acoustic densitometry (AD) of renal microstructure.


RESULTS
There was a significant difference in the peak intensity, the area under the curve and the half-time of wash-out between pre-injection and injection contrast agent. The wish-in and wish-out curve was shown in a peak shape. The renal allografts with acute rejection were significantly lower than the control group in AD (P < 0.05). No contrast opacification of renal microstructure was present in 5 failed renal allografts and the wish-in and wish-out curve appeared in a straight line shape.


CONCLUSIONS
AD is safe, and efficient in assessing renal allografts microstructure. It more sensitive in detecting allograft complication such as rejection than Doppler.
Wang
X
X
Department of Utrasound, General Hospital, People Liberation Army, Beijing 100853, China.
Mu
S
S
Ao
J
J
Zhou
G
G
D000328:Adult; D005260:Female; D006084:Graft Rejection / Q000000981:diagnostic imaging*; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D014184:Transplantation, Homologous; D018608:Ultrasonography, Doppler