Epigenetics: monoallelic expression in the immune system.
Epigenetic modifications to DNA and chromatin programme important genome functions including gene expression, chromosomal architecture and stability, and the maintenance of developmental states. Recent findings further implicate epigenetic modifications in the control of allelic choice in the immune system.
Rada
Cristina
C
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. car@mrc-lmb.cam.ac.uk
Ferguson-Smith
Anne C
AC
D000483:Alleles; D002454:Cell Differentiation; D002455:Cell Division; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D004261:DNA Replication; D005786:Gene Expression Regulation; D015321:Gene Rearrangement; D007107:Immune System / Q000378:metabolism*; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D045567:VDJ Recombinases
D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases