title: Sinusoidal spread of liver metastases from renal cell carcinoma: simulation of diffuse liver disease on MR imaging.
abstract: Rarely, hepatic metastases can simulate hepatic infiltrative diseases. We present a case of a patient with advanced metastatic renal cell carcinoma who developed hepatomegaly and clinical signs of hepatocellular injury. On magnetic resonance imaging, the injury simulated a diffuse process, e.g., acute fulminant viral or chemical hepatitis or drug toxicity. Despite its high resolution, magnetic resonance imaging might not depict focal lesions in patients with extensive metastases. In correlation with clinical history, malignant disease should be considered when diffusely abnormal hepatic signal intensity is noted.
authors.affiliation: Department of Radiology, Thomas Jefferson University Hospital, 132 South 10th Street, 1096 Main Building, Philadelphia, PA 19107, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Nascimento
authors.forename: D G
authors.initials: DG
authors.lastname: Mitchell
authors.forename: R
authors.initials: R
authors.lastname: Rubin
authors.forename: E
authors.initials: E
authors.lastname: Weaver
mesh_terms: D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000556:secondary*; D003937:Diagnosis, Differential; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008107:Liver Diseases / Q000175:diagnosis; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged