A rapid spectrophotometric method for the determination of mefloquine hydrochloride.
A simple ultraviolet spectrophotometric method for the estimation of mefloquine hydrochloride in methanol (ME(2)) has been developed and has been compared with the reported ultraviolet spectrophotometric method in 0.1 N hydrochloric acid (ME(1)). Analytical parameters such as stability, selectivity, accuracy and precision have been established for both the methods and evaluated statistically to assess the application of the individual methods. Both the methods were compared with the existing pharmacopoeial method for estimation of the drug. Both the methods were found to have the advantages for simplicity, stability, sensitivity, reproducibility and accuracy for using as an alternate to the existing non-spectrophotometric methods for the routine analysis of the drug in pharmaceutical formulations and also in pharmaceutical investigations involving mefloquine hydrochloride.
Rao
Ashwin B
AB
Pharmacy Department, Faculty of Technology and Engineering, M.S. University of Baroda, Kalabhavan, Vadodara, India.
Murthy
R S R
RS
D000962:Antimalarials / Q000032:analysis*; D015767:Mefloquine / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
D000962:Antimalarials; D015767:Mefloquine