title: Role of color flow Doppler sonography in pre-operative diagnostics of the thyroid pathology.
abstract: BACKGROUND
  The aim of this work is to demonstrate the high effectiveness of preoperative diagnosis by echotomographic study of thyroid nodules through color-Doppler sonography integrated by B-mode. The authors performed both B-mode ultrasonography and color-Doppler sonography on 125 patients expecting total thyroidectomy surgical intervention, without a previous evaluation of a number of other already performed clinical and instrumental tests. After the intervention, we compared the histologic test with the data drawn from the ultrasound scan, in order to demonstrate that color-Doppler sonography is able to provide for additional diagnostic information in the preoperative period.
  
  
  METHODS
  One hundred and twenty five patients with thyroid pathologies were examined by both B-mode and color-Doppler sonography. Two diagnoses were made for each clinical case: the first supported by B-mode data, the second based on vascularity. Our aim was to check color-Doppler's ability to provide new information in the ultrasound diagnosis. All patients underwent a total thyroidectomy surgical intervention. The data were examined by K concordance test.
  
  
  RESULTS
  Ultrasound data were compared with the histologic test, which showed 118 (97.4%) benign and 7 (5.6%) malignant lesions. B-mode ultrasound test gave a correct diagnosis in 115 (97%) out of 118 benign lesions and in 4 (57%) out of 7 malignant lesions, while 3 (2.5%) out of 118 cases were false positive and 3 (42.8%) out of 7 were false negative. In those cases showing a wrong conventional ultrasound diagnosis, after the integration of B-mode with color-Doppler results, a decrease was recorded in both false negative and false positive.
  
  
  CONCLUSIONS
  Even if no correspondence was found between the different aspects of blood flow and the histologic types of lesions, this experience proves that the color-Doppler test has a high predictive value of benignity in cases with pattern I II and IV, while lesions with pattern III should be more carefully examined, since both malignant and benign lesions belong to this group. From the data drawn from this study, we are able to infer that color-Doppler sonography is undoubtedly an advantage not only in terms of cutting the false negatives, but also in the aim of obtaining a higher effectiveness in the screening of goitrogenic pathology.
authors.affiliation: Department of Surgical, Anatomical and Oncological Science, University of Palermo, Italy. giammanco@interfree.it
authors.forename: M
authors.initials: M
authors.lastname: Giammanco
authors.forename: G
authors.initials: G
authors.lastname: Di Gesù
authors.forename: M F
authors.initials: MF
authors.lastname: Massenti
authors.forename: B
authors.initials: B
authors.lastname: Di Trapani
authors.forename: G
authors.initials: G
authors.lastname: Vetri
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000098:blood supply / Q000000981:diagnostic imaging; D000236:Adenoma / Q000098:blood supply / Q000000981:diagnostic imaging; D018249:Adenoma, Oxyphilic / Q000098:blood supply / Q000000981:diagnostic imaging; D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000098:blood supply / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006111:Graves Disease / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D013964:Thyroid Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging*; D016606:Thyroid Nodule / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000601:surgery; D013965:Thyroidectomy; D018615:Ultrasonography, Doppler, Color