title: Post-trial administration of vasopressin in humans does not enhance memory formation (vasopressin and memory consolidation).
abstract: Many animal studies show an enhancing effect of vasopressin (VP) on memory, but not all human studies could confirm this finding. This study examined the influence of post-learning administration of VP (40 IU, intranasally) on the consolidation of declarative memories in healthy humans during different intervals of sleep and waking. We could not find any effect of VP on memory consolidation, but EEG activity indicated a significant arousing influence of VP. Results suggest that if VP affects memory function it might do so primarily at the stage of encoding of the materials to be learned but it leaves unaffected processes of consolidation.
authors.affiliation: Clinical Neuroendocrinology, University of Lübeck, Lübeck, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Gais
authors.forename: Marcel
authors.initials: M
authors.lastname: Sommer
authors.forename: Stefan
authors.initials: S
authors.lastname: Fischer
authors.forename: Boris
authors.initials: B
authors.lastname: Perras
authors.forename: Jan
authors.initials: J
authors.lastname: Born
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology; D014667:Vasopressins / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014662:Vasoconstrictor Agents; D014667:Vasopressins