[Genetic mutations, acquired coagulation system disorders and obstetric pathology. Personal experience].
BACKGROUND
To evaluate the incidence of thrombophilic disorders such as Factor II mutation, Leiden factor V and MTHFR genotype, and anti-phospholipid anti-bodies syndrome in women with or without pregnancy related problems.


METHODS
Sixty-three patients (group A) with pregnancy complications were included in the study and tested for Factor V mutation, Factor II mutation, 5-10 MTHFR reductase mutation and anti-phospholipid antibodies syndrome. The incidence of disorders was compared with thirty-six pregnancies without complications (control study, group B).


RESULTS
Hemostasis thrombophilic like disorders, were significantly high (p=0.001 vs group B). Nobody in both groups was homozygous for Leiden mutation or prothrombin mutation (Factor II). The prevalence of Factor V mutation in heterozygosis was significantly (p=0.01) higher in group A in comparison with group B. The MTHFR mutation in homozygosis was found in 21.4% of group A while in the control group it was 11%. Factor II mutation in heterozygosis and anti-phospholipid antibodies were found only in group A.


CONCLUSIONS
It is important to evaluate the hemocoagulation patterns in women with a history of complicated pregnancies.
Arcadia
P
P
Istituto di Scienze Ginecologiche, Università degli Studi Magna Graecia, Catanzaro, Italy.
Cosco
A G
AG
Ierullo
A M
AM
Palomba
S
S
Guarany
R
R
Muleo
G
G
Santoro
R
R
Zullo
F
F
D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D015994:Incidence; D009154:Mutation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence