title: Imaging and quantitation of the hypoxic cell fraction of viable tumor in an animal model of intracerebral high grade glioma using [18F]fluoromisonidazole (FMISO).
abstract: We have demonstrated that FMISO uptake is significantly higher in tumor tissue in the C6 intracerebral glioma rat model compared to normal brain, and that there is persisting hypoxia in gliomas independent of tumor size. FMISO uptake was observed homogeneously throughout viable glioma tissue in tumor sizes ranging from 2mm to almost 1cm. Quantitation of uptake of FMISO showed a tumor/brain ratio of 1.9 and a tumor/blood ratio of 2.6 at 2 hours post injection.
authors.affiliation: Centre for PET, Austin & Repatriation Medical Centre, 3084, Melbourne, Victoria, Australia. htd@austin.unimelb.edu.au
authors.forename: Henri J
authors.initials: HJ
authors.lastname: Tochon-Danguy
authors.forename: John I
authors.initials: JI
authors.lastname: Sachinidis
authors.forename: Fiona
authors.initials: F
authors.lastname: Chan
authors.forename: J Gordon
authors.initials: JG
authors.lastname: Chan
authors.forename: Catherine
authors.initials: C
authors.lastname: Hall
authors.forename: Lawrence
authors.initials: L
authors.lastname: Cher
authors.forename: Stan
authors.initials: S
authors.lastname: Stylli
authors.forename: John
authors.initials: J
authors.lastname: Hill
authors.forename: Andrew
authors.initials: A
authors.lastname: Kaye
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Scott
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D015687:Cell Hypoxia; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics / Q000652:urine; D005910:Glioma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008920:Misonidazole / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; C031843:fluoromisonidazole; D008920:Misonidazole