[Influence of transjugular intrahepatic portosystemic stent shunts on portal and systemic hemodynamics of patients with portal hypertension].
OBJECTIVE
To determine the influence of transjugular intrahepatic portosystemic stent shunts (TIPSS) on portal and systemic hemodynamics of patients with portal hypertension.


METHODS
Fifteen patients who had undergone TIPSS with 10 mm stents were studied. The parameters of portal, systemic and pulmonary hemodynamics were measured with Doppler sonography, direct portal pressure measurement, blood-gas analysis and Swan-Ganz catheter before and 30 min and 2 weeks after TIPSS.


RESULTS
Portal pressure decreased by 34% and 55.4%, and PO(2), SatO(2) increased by 67.7%, 21.3% and 68%, 20.4% respectively 30 min and 2 weeks after TIPSS. Portal blood velocity increased by 1.4 times 2 weeks after TIPSS. CO, CI, SI increased (P < 0.01) and SVR, PVR decreased (P < 0.01) after TIPSS. Also, RAP, PAP increased (P < 0.05). Renal blood flow increased (P < 0.01) and renal function significantly improved.


CONCLUSIONS
TIPSS can not only decrease portal pressure and improve renal function, but also worsen portal and systemic hemodynamics. Cardiac and liver function should be monitored before and after TIPSS.
Wu
X
X
General Hospital of Nanjing Unit, Chinese People's Liberation Army, Nanjing 210002.
Li
J
J
Cao
J
J
Wu
X
X
Ni
X
X
D001775:Blood Circulation; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D011169:Portal Vein / Q000502:physiology; D019168:Portasystemic Shunt, Transjugular Intrahepatic