Solid phase chemical technologies for combinatorial chemistry.
This article describes the exploration of synthetic methodologies on solid phase for combinatorial chemistry. Examples will cover various cyclisation strategies that include; the intramolecular Heck cyclisation leading to the formation of oxindoles, the radical cyclisation mechanism in the synthesis of furans, and a stereoselective cyclisation to form oxopiperazines.
Balasubramanian
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University Chemical Laboratory, University of Cambridge, Cambridge, United Kingdom. sb10031@cam.ac.uk
D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis; D008968:Molecular Conformation; D010879:Piperazines / Q000138:chemical synthesis
D001572:Benzofurans; D005609:Free Radicals; D005663:Furans; D007211:Indoles; D010879:Piperazines; C105430:benzofuran