Race and cancer genetics: lessons from BRCA1.
The effect of a patient's race or ethnicity on cancer incidence and mortality rates remains a neglected area of cancer research. However, with cancer statistics differing among various populations, research on racial and ethnic groups could provide clues to cancer trends. Definitions of ethnicity and/or race need to be established and standardizedfor use in study protocols. Accordingly, all research on ethnic groups must address two questions: (1) When is genetic research on a population appropriate? (2) How should researchers define a given population being studied?
Hoffman
Leslie Klein
LK
Johns Hopkins School of Medicine, Baltimore, Maryland, USA. lcklein@jhmi.edu
D019313:BRCA1 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000208:ethnology* / Q000235:genetics*; D005006:Ethnicity; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D018095:Germ-Line Mutation; D006801:Humans; D012307:Risk Factors
D019313:BRCA1 Protein