title: The Laugier-Hunziker syndrome.
abstract: Laugier and Hunziker described a syndrome consisting of asymptomatic benign areas of hyperpigmentation affecting the lips, buccal mucosa and, in 50%, the fingernails. We report a 67-year-old woman with the clinical features of Laugier-Hunziker syndrome in association with vulval pigmentation. Histology, immunohistochemistry and electron microscopy from the various areas of pigmentation on the body confirmed the benign nature of the pigmentation. We review potential causes of oral and genital pigmentation, and suggest an expansion of the original syndrome described by Laugier and Hunziker to include more widespread areas of benign hyperpigmentation, which may associated.
authors.affiliation: Regional Centre of Dermatology, Mater Misericordiae Hospital, Dublin, Ireland.
authors.forename: P
authors.initials: P
authors.lastname: Lenane
authors.forename: D O
authors.initials: DO
authors.lastname: Sullivan
authors.forename: C O
authors.initials: CO
authors.lastname: Keane
authors.forename: S O
authors.initials: SO
authors.lastname: Loughlint
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000150:complications / Q000175:diagnosis*; D007150:Immunohistochemistry; D008047:Lip Diseases / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology; D009260:Nail Diseases / Q000150:complications / Q000473:pathology*; D011379:Prognosis; D013577:Syndrome; D014845:Vulvar Diseases / Q000150:complications / Q000473:pathology*