Eptifibatide and 7E3, but not tirofiban, inhibit alpha(v)beta3 integrin-mediated binding of smooth muscle cells to thrombospondin and prothrombin.
Scarborough
Robert M
RM
D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D000077542:Eptifibatide; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D011485:Protein Binding / Q000187:drug effects; D011516:Prothrombin / Q000378:metabolism; D019030:Receptors, Vitronectin / Q000037:antagonists & inhibitors* / Q000187:drug effects / Q000378:metabolism; D019699:Thrombospondins / Q000378:metabolism; D000077466:Tirofiban; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019030:Receptors, Vitronectin; D019699:Thrombospondins; D014443:Tyrosine; D011516:Prothrombin; D000077466:Tirofiban; D000077542:Eptifibatide