Synthesis and molecular mechanical studies of antiviral copper(II) complexes with morpholinebiguanide drug.
The synthesis and characterization of new Cu(II) complexes with morpholinebiguanide drug are described. The complexes formed have been characterized by elemental analysis, IR, UV-VIS, conductance measurements, EPR spectra and magnetic susceptibility measurements. Their biological activity is supported by the experimental data and enhanced by the theoretical ones. The morpholinebiguanide ligand and their copper(II)-complexes were studied by molecular mechanics program.
Patrinoiu
G
G
I. G. Murgulescu Institute of Physical Chemistry, Department of Coordination Chemistry, Spl. Independentei 202, 77208 Bucharest, Romania.
Patron
L
L
Weinberg
J
J
Nita
S
S
Meghea
A
A
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001645:Biguanides; D002413:Cations, Divalent; D003300:Copper / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D015394:Molecular Structure; D009025:Morpholines / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013055:Spectrophotometry, Infrared
D000998:Antiviral Agents; D001645:Biguanides; D002413:Cations, Divalent; D009025:Morpholines; D003300:Copper; C005267:moroxydine