title: [Effect of sevoflurane on spinal dorsal horn WDR neuronal activity in cats].
abstract: The effects of sevoflurane (0.5%, 1.5%, and 2.5%) on the spinal dorsal horn wide dynamic range (WDR) neuronal activity were studied in either spinal cord intact or spinal cord-transected cats. Extracellular activity was recorded in the dorsal horn from single WDR neurons responding to noxious and non-noxious stimuli applied to the cutaneous receptive fields on the left hind foot pads of intact cats or decerebrate and spinal cord-transected (L 1-2) cats. The experiment was divided into two sections. When bradykinin (BK) 10 micrograms was injected into the femoral artery contralateral to the recording site as a noxious test stimulus in the spinal cord-transected cat, 7 of 15 WDR neurons gave inhibitory responses which were depressed by 0.5%, 1.5%, and 2.5% sevoflurane. On the other hand, when the injection of BK 10 micrograms into the femoral artery contralateral to the recording site was used in the spinal cord-intact cat, all of 7 WDR neurons gave inhibitory responses, which were significantly depressed by 0.5%, 1.5%, and 2.5% sevoflurane. The results suggest that sevoflurane reduces the inhibition of dorsal horn WDR neuronal activities induced by BK injection in spinal cord-intact cats as well as in spinal cord-transected cats.
authors.affiliation: Department of Anesthesiology, Meikai University School of Dentistry, Sakado 350-0283.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagasaka
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Takahara
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D003655:Decerebrate State; D008738:Methyl Ethers / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D000077149:Sevoflurane; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane