[Pharmacokinetical study of safflor yellow on rat acute model of blood stasis syndrome].
OBJECTIVE
To study the pharmacokinetical character of safflor yellow in rat acute model of blood stasis syndrome.


METHODS
The rat acute model of blood stasis syndrome was made by i.p. adrenalin (0.07 ml/kg) and the stimulation of ice-water. At the time of 5, 10, 30, 60, 120, 180, 320, 480 min, the concentration of safflor yellow in the serum after i.v. safflor yellow (37.08 ml/kg) was determined.


RESULTS
The concentration-time date of safflor yellow in rat acute model of blood stasis syndrome was shown to fit a double-compartment open model, t1/2 alpha = 1.43 min, t1/2 beta = 95.65 min, AUC = 49,632.90 micrograms.min/ml; while the concentration-time data of safflor yellow in normal rat was shown to fit a single-compartment open model, t1/2 alpha = 66.27 min, AUC = 42,267 micrograms.min/ml.


CONCLUSIONS
The metabolism of safflor yellow was evidently later in rat acute model of blood stasis syndrome than in normal rat.
Yang
Z
Z
Xijing Hospital, Fourth Military Medical University, Xi'an 710032.
Wen
A
A
Mei
Q
Q
Jiang
Y
Y
Zhao
M
M
Zhang
S
S
D000208:Acute Disease; D000818:Animals; D002599:Chalcone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D018056:Hemorheology; D008297:Male; D008516:Medicine, Chinese Traditional; D051381:Rats; D017207:Rats, Sprague-Dawley
C076422:safflower yellow; D002599:Chalcone