title: Differential scanning calorimetric study of the binding of the primary water of hydration to nucleosides.
abstract: Differential scanning calorimetry was used to study the water of hydration of all of the nucleosides at 59% relative humidity. Hydration was observed in pristine samples of guanosine, (rG), deoxyguanosine, (dG), and deoxyadenosine, (dA). Two inequivalent water sites were observed in dG and one site in rG. Re-hydration was observed in rG and dG, but not in dA. The activation energies for rG were 0.697 +/- 0.051 eV and 0.683 plus minus 0.090 eV for pristine and cycled samples respectively. dG had activation energies of 0.726 +/- 0.026 eV and 0.997 +/- 0.034 eV for the first and second peaks in the pristine samples while the activation energy for cycled dG was 0.671 +/- 0.133 eV.
authors.affiliation: Department of Physics and Astronomy, University of Toledo, Toledo, OH 43606, USA.
authors.forename: D
authors.initials: D
authors.lastname: Cavanaugh
authors.forename: S A
authors.initials: SA
authors.lastname: Lee
mesh_terms: D001665:Binding Sites; D002152:Calorimetry, Differential Scanning; D003839:Deoxyadenosines / Q000737:chemistry; D003849:Deoxyguanosine / Q000737:chemistry; D006151:Guanosine / Q000737:chemistry; D009705:Nucleosides / Q000737:chemistry*; D013816:Thermodynamics; D014867:Water
chemical_list: D003839:Deoxyadenosines; D009705:Nucleosides; D014867:Water; D006151:Guanosine; D003849:Deoxyguanosine