Hitchhiking fads en route to peroxisomes.
A unique aspect of protein translocation across the peroxisomal membrane is that folded and oligomeric proteins get across this membrane (Purdue and Lazarow, 2001). The generality of this rule, its specific features, and its mechanism are not fully understood. A paper in this issue addresses, in a very thorough fashion, the assembly, cofactor binding, and import of an oligomeric protein, acyl-CoA oxidase (Aox), into the peroxisome matrix (Titorenko et al., 2002, this issue).
Subramani
Suresh
S
Section of Molecular Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA. ssubramani@ucsd.edu
D042962:Acyl-CoA Oxidase; D000818:Animals; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D010088:Oxidoreductases / Q000096:biosynthesis*; D020675:Peroxisomes / Q000378:metabolism*; D011108:Polymers / Q000378:metabolism*; D011387:Prokaryotic Cells / Q000166:cytology / Q000378:metabolism; D017510:Protein Folding; D017434:Protein Structure, Tertiary / Q000502:physiology; D021381:Protein Transport / Q000502:physiology*
D011108:Polymers; D010088:Oxidoreductases; D042962:Acyl-CoA Oxidase