title: Resolution of chronic idiopathic thrombocytopenia purpura following syngeneic peripheral blood progenitor transplant.
abstract: Idiopathic thrombocytopenia purpura (ITP) is an acquired disease of children and adults characterized by a low platelet count, an essentially normal bone marrow, and absence of evidence for other disease. We report the use of syngeneic peripheral blood progenitor transplantation (PBPT) in a 19-year-old male with chronic refractory ITP since the age of 5. Engraftment was successful and has resulted in resolution of his disease. We conclude that syngeneic PBPT is a potentially curative option for refractory ITP.
authors.affiliation: Tulane Cancer Center, Tulane Bone Marrow Transplant Program and Department of Medicine, Tulane University, New Orleans, LA 70112-2699, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Zaydan
authors.forename: C
authors.initials: C
authors.lastname: Turner
authors.forename: A M
authors.initials: AM
authors.lastname: Miller
mesh_terms: D000328:Adult; D001773:Blood Cells / Q000637:transplantation; D002908:Chronic Disease; D018572:Disease-Free Survival; D006085:Graft Survival; D006801:Humans; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000628:therapy*; D014185:Transplantation, Isogeneic; D014430:Twins, Monozygotic