title: Impact of duodenal feeding on the oxygen balance of the splanchnic region during different phases of severe burn injury.
abstract: Enteral nutrition is recommended in burned patients. Depending on the amount administered, enteral feeding causes an increase of intestinal oxygen-demand. Since intestinal perfusion is decreased after major burns the aim of this study was to evaluate, whether duodenal feeding might be a cofactor for the development of a splanchnic O(2)-imbalance. In 15 severely burned patients during duodenal feeding starting within 6 h after injury the assessment of the CO(2)-gap between arterial and gastric CO(2), as a parameter for the measurement of intestinal O(2)-balance was performed. Beginning prior to enteral nutrition CO(2)-gap measurements were carried out to show when the CO(2)-gap increased above 30 mmHg during the whole critical illness phase of the patients. When the CO(2)-gap increased above 30 mmHg enteral nutrition was reduced by 50% and the CO(2)-gap was measured 1 h later. In none of the patients the CO(2)-gap increased during increase of enteral nutrition. In seven patients, the CO(2)-gap increased between the 6th and 13th day above 30 mmHg and fell significantly 1 h after reduction of enteral nutrition. Contrary to the early postburn phase, enteral feeding might have adverse effects on the oxygen balance of the intestine in the later stages of the critical illness phase.
authors.affiliation: Department of Anesthesiology and Intensive Care, Vienna Medical School, University of Vienna, 18--20 Waehringer Guertel, A-1090, Vienna, Austria. harald.andel@univie.ac.at
authors.forename: Harald
authors.initials: H
authors.lastname: Andel
authors.forename: Matthias
authors.initials: M
authors.lastname: Rab
authors.forename: Dorothea
authors.initials: D
authors.lastname: Andel
authors.forename: Klaus
authors.initials: K
authors.lastname: Horauf
authors.forename: Dagmar
authors.initials: D
authors.lastname: Felfernig
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Schramm
authors.forename: Michael
authors.initials: M
authors.lastname: Zimpfer
mesh_terms: D000328:Adult; D000368:Aged; D002056:Burns / Q000378:metabolism* / Q000628:therapy*; D002245:Carbon Dioxide / Q000378:metabolism; D016638:Critical Illness / Q000628:therapy; D004386:Duodenum / Q000378:metabolism*; D002149:Energy Intake; D004750:Enteral Nutrition / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007441:Intubation, Gastrointestinal / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D012720:Severity of Illness Index
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen