New pyrrolizidinone antibiotics CJ-16,264 and CJ-16,367.
Two new antibiotics, CJ-16,264 (I) and CJ-16,367 (II), were isolated from the fermentation broth of an unidentified fungus CL39457. These antibiotics have a pyrrolizidinone skeleton, first discovered in fungi. Compounds I and II inhibit the growth of Gram-positive multi-drug resistant bacteria and some Gram-negative strains such as Moraxella catarrhalis and Escherichia coli with altered permeability (imp). Comparison of an antibacterial profile between the two compounds suggested that the gamma-lactone portion of I is important for the activity.
Sugie
Y
Y
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. Yutaka.Sugie@japan.pfizer.com
Hirai
H
H
Kachi-Tonai
H
H
Kim
Y J
YJ
Kojima
Y
Y
Shiomi
Y
Y
Sugiura
A
A
Sugiura
A
A
Suzuki
Y
Y
Yoshikawa
N
N
Brennan
L
L
Duignan
J
J
Huang
L H
LH
Sutcliffe
J
J
Kojima
N
N
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D005285:Fermentation; D005658:Fungi / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; C447443:CJ-16,246; C447444:CJ-16,367; D007783:Lactones; D011758:Pyrroles