Serum copper, zinc, selenium, glutathione peroxidase and superoxide dismutase levels in epileptic children before and after 1 year of sodium valproate and carbamazepine therapy.
To assess whether epileptic children have abnormal values of serum copper (Cu), zinc (Zn), selenium (Se), glutathione peroxidase (GSH-PX) and superoxide dismutase (CuZn-SOD), and to evaluate the effect of long-term therapy with sodium valproate (VPA) and carbamazepine (CBZ) on these parameters, we studied 36 epileptic patients before the beginning of therapy and after 1 year of therapy with VPA or CBZ. Before the beginning of therapy, there were no differences in levels of all parameters studied between controls and epileptics. After 1 year of therapy, patients treated with VPA and CBZ continued to show normal values. In conclusion our study demonstrates that epilepsy per se and treatment with VPA and CBZ do not affect levels of Cu, Zn, Se, GSH-PX and CuZn-SOD concentrations.
Verrotti
A
A
Department of Medicine, Division of Pediatrics, University of Chieti, Ospedale Policlinico, via dei Vestini 5, I-66100 Chieti, Italy. averrott@obelix.unich.it
Basciani
F
F
Trotta
D
D
Pomilio
M P
MP
Morgese
G
G
Chiarelli
F
F
D000293:Adolescent; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000627:therapeutic use; D002220:Carbamazepine / Q000627:therapeutic use*; D003300:Copper / Q000097:blood; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008297:Male; D008670:Metals / Q000097:blood*; D012643:Selenium / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood*; D013997:Time Factors; D014635:Valproic Acid / Q000627:therapeutic use*; D015032:Zinc / Q000097:blood
D000927:Anticonvulsants; D008670:Metals; D002220:Carbamazepine; D014635:Valproic Acid; D003300:Copper; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium; D015032:Zinc