title: Lamotrigine plus leukocyte filtration as a neuroprotective strategy in experimental hypothermic circulatory arrest.
abstract: BACKGROUND
  Lamotrigine and leukocyte filtration seem to improve cerebral protection during experimental hypothermic circulatory arrest (HCA). This study was performed to evaluate whether their combined use may further improve cerebral protection.
  
  
  METHODS
  Twenty-four pigs undergoing 75-minute period of HCA at 20 degrees C were randomly assigned to receive saline; lamotrigine (20 mg/kg) before HCA (L); or lamotrigine (20 mg/kg) before HCA plus leukocyte filtration before and after HCA (L + LF).
  
  
  RESULTS
  Seven animals (87%) in the L + LF group, 4 (50%) in the L group, and 3 (37%) in the control group were alive on the seventh postoperative day. The median electroencephalogram burst recovery was 94% in the L + LF group (p = 0.024 versus control group), 81% in the L group, and 64% in the control group. Among the surviving animals, the median behavioral scores were 9, 9, and 6 at the seventh day, respectively (p = 0.005 between the L + LF group and the control group). The median histopathologic score was 14 in the L + LF group (p = 0.046 versus control group), 14.5 in the L group (p = 0.062 versus control group), and 21 in the control group.
  
  
  CONCLUSIONS
  Lamotrigine has neuroprotective effect during HCA. The combined use of lamotrigine and LF may further improve the survival outcome.
authors.affiliation: Department of Surgery, University of Oulu, Finland.
authors.forename: Jussi
authors.initials: J
authors.lastname: Rimpiläinen
authors.forename: Pekka
authors.initials: P
authors.lastname: Romsi
authors.forename: Matti
authors.initials: M
authors.lastname: Pokela
authors.forename: Jorma
authors.initials: J
authors.lastname: Hirvonen
authors.forename: Vilho
authors.initials: V
authors.lastname: Vainionpää
authors.forename: Kai T
authors.initials: KT
authors.lastname: Kiviluoma
authors.forename: Fausto
authors.initials: F
authors.lastname: Biancari
authors.forename: Pasi
authors.initials: P
authors.lastname: Ohtonen
authors.forename: Ville
authors.initials: V
authors.lastname: Jäntti
authors.forename: Vesa
authors.initials: V
authors.lastname: Anttila
authors.forename: Tatu
authors.initials: T
authors.lastname: Juvonen
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000473:pathology / Q000517:prevention & control*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004569:Electroencephalography; D005260:Female; D005374:Filtration; D006324:Heart Arrest, Induced; D006440:Hemofiltration; D007036:Hypothermia, Induced; D000077213:Lamotrigine; D007962:Leukocytes; D011897:Random Allocation; D015427:Reperfusion Injury / Q000517:prevention & control*; D013552:Swine; D014227:Triazines / Q000627:therapeutic use*
chemical_list: D002121:Calcium Channel Blockers; D014227:Triazines; D000077213:Lamotrigine