Neurogenesis in adult primate neocortex: an evaluation of the evidence.
Reports of continuous genesis and turnover of neurons in the adult primate association neocortex--the site of the highest cognitive functions--have generated great excitement. Here, I review the available evidence, and question the scientific basis of this claim.
Rakic
Pasko
P
Pasko Rakic is at the Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. pasko.rakic@yale.edu
D000818:Animals; D000963:Antimetabolites / Q000378:metabolism; D015415:Biomarkers; D001973:Bromodeoxyuridine / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology; D004247:DNA / Q000378:metabolism; D008251:Macaca; D008959:Models, Neurological; D019579:Neocortex / Q000166:cytology* / Q000502:physiology*; D009457:Neuroglia / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009711:Nucleotides / Q000378:metabolism
D000963:Antimetabolites; D015415:Biomarkers; D009711:Nucleotides; D004247:DNA; D001973:Bromodeoxyuridine