title: Palladium(0)-catalyzed coupling of organozinc iodide reagents with bromopyridines: synthesis of selectively protected pyridine-containing azamacrocycles.
abstract: The synthesis of azamacrocycles in which the ring nitrogens are regioselectively functionalized is described. An organozinc palladium(0)-catalyzed coupling with an appropriately functionalized bromopyridine generated a key intermediate, which was transformed in two steps to a desired precursor and subjected to an intramolecular N-alkylation to effect a macrocyclization affording selectively protected azamacrocycles 1-3.
authors.affiliation: AnorMED, Inc., #200-20353 64th Avenue, Langley, British Columbia, Canada V2Y 1N5. rskerlj@anormed.com
authors.forename: Renato T
authors.initials: RT
authors.lastname: Skerlj
authors.forename: Yuanxi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Trevor
authors.initials: T
authors.lastname: Wilson
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Bridger