title: Synthesis and vasorelaxant activity of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans.
abstract: A series of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans related to cromakalim (1) has been prepared and their vasorelaxant activities on isolated rat thoracic aorta precontracted with phenylephrine have been evaluated. The relaxant mechanism of 3a was found not through ATP-sensitive K(+) channels as cromakalim, but through opening voltage-sensitive K(+) channels.
authors.affiliation: National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC.
authors.forename: Wen Fei
authors.initials: WF
authors.lastname: Chiou
authors.forename: Shyh Yuan
authors.initials: SY
authors.lastname: Li
authors.forename: Li Kang
authors.initials: LK
authors.lastname: Ho
authors.forename: Ming Ling
authors.initials: ML
authors.lastname: Hsien
authors.forename: Ming Jaw
authors.initials: MJ
authors.lastname: Don
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D015221:Potassium Channels / Q000187:drug effects; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D015221:Potassium Channels; D011714:Pyrans; D014665:Vasodilator Agents