title: [Anemia and neutropenia in primary empty sella syndrome].
abstract: BACKGROUND
  A 64-year-old man was admitted to our hospital with significant weight loss and symptoms of fatigue. He had normocytic anaemia and absolute neutropenia in peripheral blood.
  
  
  METHODS
  Further haematological and endocrinological investigations were performed.
  
  
  RESULTS
  Bone marrow aspiration and biopsy showed dysplastic signs. Immunophenotyping and cytogenetics did not provide evidence of primary haematological disease. Endocrinological testing demonstrated secondary adrenal insufficiency. Magnetic resonance imaging of the sella turcica showed an empty sella. Cortisol substitution eliminated the symptoms of the patient and normalised his peripheral blood values. The disturbed maturity and hypoplasia of the bone marrow were also normalised.
  
  
  CONCLUSIONS
  Normalisation of haematopoiesis after cortisol substitution indicates that cortisol plays an important role in the regulation of haematopoiesis. Primary empty sella syndrome with isolated ACTH cortisol deficiency is a very rare cause of disturbed haematopoiesis.
authors.affiliation: Medisinsk avdeling, Regionsykehuset i Tromsø 9038 Tromsø. randi.fykse.hallstensen@rito.no
authors.forename: R F
authors.initials: RF
authors.lastname: Hallstensen
authors.forename: J
authors.initials: J
authors.lastname: Svartberg
authors.forename: V
authors.initials: V
authors.lastname: Isaksen
authors.forename: R
authors.initials: R
authors.lastname: Bajic
authors.forename: M L
authors.initials: ML
authors.lastname: Løchen
authors.forename: J B
authors.initials: JB
authors.lastname: Hansen
mesh_terms: D000328:Adult; D000740:Anemia / Q000150:complications / Q000175:diagnosis*; D001853:Bone Marrow / Q000473:pathology; D001856:Bone Marrow Examination; D003937:Diagnosis, Differential; D004652:Empty Sella Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D006410:Hematopoiesis / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications / Q000175:diagnosis*; D012658:Sella Turcica / Q000473:pathology
chemical_list: D006454:Hemoglobins