title: [19 cases of Paget's disease].
abstract: OBJECTIVE
  The clinical signs of Paget's disease are similar to those of chronic eczema. The two are often confused, especially extramammary Paget's disease. Only biopsy can help to differentiate them correctly.
  
  
  METHODS
  19 patients with Paget's disease were reviewed with regard to clinical analysis and treatment from 1987 to 1997.
  
  
  RESULTS
  Six patients had breast Paget's disease and 13 had extramammary one. The latter involved scrotum and penis in 11 patients, the groin in 1, and perianal and anal in 1. Follow up showed that 3 patients had recurrences in extramammary patients who had had positive surgical margin biopsy. One patient died of other disease.
  
  
  CONCLUSIONS
  Surgery is the first choice of treatment for Paget's disease either of breast or of extramammary regions. Negative margins must be achieved to prevent local recurrence.
authors.affiliation: Department of Plastic Surgry, Ren Ji Hospital, Shanghai Second Medical University, Shanghai 200001.
authors.forename: M
authors.initials: M
authors.lastname: Fu
authors.forename: S
authors.initials: S
authors.lastname: Gao
authors.forename: P
authors.initials: P
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis / Q000601:surgery; D005260:Female; D005834:Genital Neoplasms, Male / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010145:Paget Disease, Extramammary / Q000175:diagnosis / Q000601:surgery; D010144:Paget's Disease, Mammary / Q000175:diagnosis / Q000601:surgery; D010412:Penile Neoplasms / Q000175:diagnosis / Q000601:surgery; D012189:Retrospective Studies; D012611:Scrotum / Q000473:pathology / Q000601:surgery