Vaticanol C, a novel resveratrol tetramer, inhibits cell growth through induction of apoptosis in colon cancer cell lines.
A novel resveratrol tetramer, vaticanol C, isolated from the stem bark of Vatica rassak markedly suppressed cell growth through induction of apoptosis, which was characterized by nuclear changes and DNA ladder formation, in three different human colon cancer cell lines.
Ito
Tetsuro
T
Gifu Pharmaceutical University, Mitahora-higashi, Japan.
Akao
Yukihiro
Y
Tanaka
Toshiyuki
T
Iinuma
Munekazu
M
Nozawa
Yoshinori
Y
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004273:DNA, Neoplasm / Q000187:drug effects; D006801:Humans; D008970:Molecular Weight; D019441:Plant Epidermis / Q000737:chemistry; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004273:DNA, Neoplasm; D013267:Stilbenes; C459559:vaticanol C; D000077185:Resveratrol