title: Extracorporeal shock wave lithotripsy of gallstones with oral dissolution. Results in course of ten years in Czech Republic in correlation to indication criteria.
abstract: OBJECTIVE
  We compared the results of treatment of gallbladder stones by extracorporeal shock wave lithotripsy with dissolution during two periods to different criteria of indication. In the first period (1990-1991) we treated patients with stones up to 3 cm in diameter. In the second period (1992-1994) the indication included stones up to 1.5 cm with gallbladder contraction on cholecystography, which was also quantitatively determined by USG exceeding 60% of fasting volume.
  
  
  METHODS
  We used Czech made lithotriptors MEDILIT. The shock waves (SW) are produced by an underwater high voltage discharge and the concentration of SW is achieved by reflection. The localization of stones is performed by means of a sonographic probe. After stone localization usually 700 SW are applied to a patient lying in prone position. Oral dissolution was started in both groups of patients two weeks before shock wave application. Ursodeoxycholic acid and chenodeoxycholic were administered in doses of 7.5 mg/kg body weight/day.
  
  
  RESULTS
  In the first group of 260 patients (average age 42), which had moderate indication criteria, disappearance of fragments during one year was found only in 148 (57%). The remaining patients were treated symptomatically or recommended to cholecystectomy. In a second group of 160 patients (average age 45), disappearance of fragments during one year was achieved in 125 (78%). We used stricter indication criteria and our results are much better compared to the first group. Only 208 patients from both groups were controlled for more 5 years, in 89 cases of this number was a recidivity of lithiasis and at 20 of them we indicated cholecystectomy, 22 of the patients refused to continue in the therapy, because the stones are asymptomatic.
  
  
  CONCLUSIONS
  In our opinion, this therapy (ESWL combined with oral dissolution) is suitable in 7% patients with gallbladder stones. Its side effects are very small, practically negligible. It can be performed without general anaesthesia and on an out-patient basis. After the advent of laparoscopic cholecystectomy we observed diminished interest of both patients and their physicians for gallbladder ESWL, however, after it has reached a widespread use, a new interest in ESWL and dissolution therapy is emerging, which we attribute to its above-mentioned advantages.
authors.affiliation: Institute of Biophysics, Charles University. benesjiri@cesnet.cz
authors.forename: J
authors.initials: J
authors.lastname: Benes
authors.forename: J
authors.initials: J
authors.lastname: Chmel
authors.forename: O
authors.initials: O
authors.lastname: Blazek
authors.forename: Z
authors.initials: Z
authors.lastname: Marecek
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002635:Chenodeoxycholic Acid / Q000008:administration & dosage*; D002756:Cholagogues and Choleretics / Q000008:administration & dosage* / Q000627:therapeutic use; D002769:Cholelithiasis / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D008096:Lithotripsy; D008875:Middle Aged; D012189:Retrospective Studies; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D002756:Cholagogues and Choleretics; D002635:Chenodeoxycholic Acid; D014580:Ursodeoxycholic Acid