[A study on transplantation of rat photoreceptor cell layer].
OBJECTIVE
To study the relationship between photoreceptors and other layers of the retina in the aspects of anatomical structure, physiology, pathology, etc.


METHODS
RCS rats were used as host animals, and the pure cone and rod layer of the donor retina was prepared from Wistar rat and was transplanted under the host retina where the cones and rods were degenerated.


RESULTS
After 2 weeks of transplantation, the retinas of the host rats were reattached, and the transplanted cells were survival. The transplanted cells were in the subretinal space between the retinal pigment epithelium (RPE) and the inner unclear layer, and they had the staining characteristics similar to that of the normal control photoreceptors.


CONCLUSIONS
In the animal model of photoreceptor cell layer transplantation, the transplanted cells possess normal anatomical location and are connected with RPE and inner nuclear layer. The results provide a new route to investigate the re-establishment of anatomical association with the optic nerve and the physiological activity of the nerve.
Wang
W
W
Department of Ophthalmology, Third Hospital of Beijing Medical University, Beijing 100083.
Ma
M
M
Bai
F
F
Zhang
H
H
D000818:Animals; D017690:Cell Transplantation / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000166:cytology / Q000637:transplantation*; D017949:Retinal Cone Photoreceptor Cells / Q000637:transplantation*; D017948:Retinal Rod Photoreceptor Cells / Q000637:transplantation*