Expression of glial cell line-derived neurotrophic factor mRNA in the human newborn and adult hippocampal formation.
Glial cell line-derived neurotrophic factor (GDNF) mRNA-containing neurons were found in normal neonate and adult human hippocampus with a localization pattern consistently similar among different ages. They were numerous in proximal CA1 to CA3 pyramidal layer, granular layer and hilus, and sparse in oriens and molecular layers. The present data provide a map of GDNF-producing neurons in the human archicortex and suggest a role for GDNF in neuronal function throughout life.
Serra
Maria Pina
MP
Department of Cytomorphology, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrat, Italy.
Quartu
Marina
M
Lai
Maria Letizia
ML
Follesa
Paolo
P
Del Fiacco
Marina
M
D000328:Adult; D000368:Aged; D000375:Aging / Q000235:genetics / Q000378:metabolism*; D051100:Glial Cell Line-Derived Neurotrophic Factor; D006624:Hippocampus / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins / Q000235:genetics*; D017966:Pyramidal Cells / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*
C495039:GDNF protein, human; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger