title: Differential expression of viral Bcl-2 encoded by Kaposi's sarcoma-associated herpesvirus and human Bcl-2 in primary effusion lymphoma cells and Kaposi's sarcoma lesions.
abstract: Expression of human herpesvirus 8 viral Bcl-2 protein was demonstrated in spindle cells of late-stage Kaposi's sarcoma lesions but not in primary effusion lymphoma cell lines. In contrast, strong expression of human Bcl-2 was found in stimulated primary effusion lymphoma cells, whereas in Kaposi's sarcoma lesions preferential mononuclear cells, and to a lesser extent spindle cells, stained positive.
authors.affiliation: Institute for Medical Microbiology, University of Basel, Petersplatz 10, CH-4003 Basel, Switzerland.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Widmer
authors.forename: Marion
authors.initials: M
authors.lastname: Wernli
authors.forename: Felix
authors.initials: F
authors.lastname: Bachmann
authors.forename: Fred
authors.initials: F
authors.lastname: Gudat
authors.forename: Gieri
authors.initials: G
authors.lastname: Cathomas
authors.forename: Peter
authors.initials: P
authors.lastname: Erb
mesh_terms: D019288:Herpesvirus 8, Human / Q000235:genetics* / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D012509:Sarcoma / Q000378:metabolism / Q000821:virology; D012514:Sarcoma, Kaposi / Q000378:metabolism* / Q000821:virology; D014407:Tumor Cells, Cultured
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2