HTLV-I-associated myelopathy: are ferritin, S100beta protein, or guanine nucleotides CSF markers of disease?
In southern Brazil, there is an endemic high prevalence foci of HTLV-I and HTLV-II infection. HTLV-infected individuals may develop HAM/TSP. Little is known about HAM/TSP pathogenesis and there is a lack of disease progression markers. This study investigated ferritin, S-100beta protein, and guanine nucleotides (GN) concentrations in the CSF of 18 patients with HAM/TSP. In HAM/TSP patients, concentrations of ferritin and S100beta were increased, whereas GMP was reduced. CSF ferritin, S100beta, and GN are potential markers for HAM/TSP.
Regner
Andrea
A
Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Bianchini
Ottomar
O
Jardim
Claudio
C
Menna-Barreto
Marcio
M
D000328:Adult; D000368:Aged; D015415:Biomarkers; D018450:Disease Progression; D005260:Female; D005293:Ferritins / Q000134:cerebrospinal fluid*; D006150:Guanine Nucleotides / Q000134:cerebrospinal fluid*; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D011237:Predictive Value of Tests; D009418:S100 Proteins / Q000134:cerebrospinal fluid*
D015415:Biomarkers; D006150:Guanine Nucleotides; D009418:S100 Proteins; C110294:S100A1 protein; D005293:Ferritins