title: Randomised trial of amnioinfusion during labour with meconium stained amniotic fluid.
abstract: OBJECTIVE
  To assess the effect of amnioinfusion during labour with meconium stained amniotic fluid on caesarean section rate and perinatal outcome.
  
  
  METHODS
  Prospective randomised controlled study.
  
  
  METHODS
  A tertiary care teaching hospital in India.
  
  
  METHODS
  Women in labour at term with meconium stained amniotic fluid.
  
  
  METHODS
  Two hundred women in labour with > or = 37 weeks gestation, single cephalic presentation with moderate or thick meconium were randomised to control and amnioinfusion groups at a 1:1 ratio. Amnioinfusion was performed using 500 mL of normal saline over a period of 30 minutes in a study group. The control group received routine care. Both groups had intermittent auscultation of fetal heart rate during labour.
  
  
  METHODS
  The primary outcome measure was caesarean section rate. Secondary outcome measures were meconium aspiration syndrome, 1 minute and 5 minute apgar < 7, hypoxic ischaemic encephalopathy, neonatal intensive care unit admission, meconium at the level of vocal cords.
  
  
  RESULTS
  The caesarean section rate in the amnioinfusion group was less than the control group (RR 0.47; 95% CI 0.24-0.93). Amnioinfusion was associated with a significant decrease in the incidence of meconium at the vocal cords (P = 0.001); improvement in 1 minute apgar scores (P < 0.05), respiratory distress (P = 0.002) and fewer admissions to nursery compared with the controls. This sample size was inadequate to study the impact on meconium aspiration syndrome.
  
  
  CONCLUSIONS
  Amnioinfusion in an under resourced labour ward decreases caesarean section rates and fetal morbidity.
authors.affiliation: Department of Obstetrics and Gynaecology, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India.
authors.forename: Asmita Muthal
authors.initials: AM
authors.lastname: Rathor
authors.forename: Ruchira
authors.initials: R
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Ramji
authors.forename: Reva
authors.initials: R
authors.lastname: Tripathi
mesh_terms: D000328:Adult; D000650:Amnion / Q000637:transplantation*; D002585:Cesarean Section / Q000706:statistics & numerical data; D005113:Extraction, Obstetrical / Q000706:statistics & numerical data; D005260:Female; D005316:Fetal Distress / Q000517:prevention & control; D005334:Fever / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008470:Meconium / Q000737:chemistry*; D008471:Meconium Aspiration Syndrome / Q000517:prevention & control; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D011644:Puerperal Disorders / Q000209:etiology; D012307:Risk Factors