title: Fluoride modifies adhesion of Streptococcus pyogenes.
abstract: Streptococcus pyogenes grown in the presence of subinhibitory concentrations of sodium fluoride had a diminished ability, compared to control cells, to adhere to buccal cells, collagen, fibronectin, and laminin. In addition, sodium fluoride was a competitive inhibitor of streptococcal adhesion to collagen and fibronectin, but not laminin. It is suggested that sodium fluoride may be useful in therapy or prophylaxis in infections involving group A streptococci.
authors.affiliation: Department of Microbiology and Immunology, University of Louisville, Health Science Center, Louisville, KY 40292, USA.
authors.forename: Junkai
authors.initials: J
authors.lastname: Cao
authors.forename: R J
authors.initials: RJ
authors.lastname: Doyle
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D006801:Humans; D012969:Sodium Fluoride / Q000494:pharmacology*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D012969:Sodium Fluoride