Activities of polymyxin B and cecropin A-,melittin peptide CA(1-8)M(1-18) against a multiresistant strain of Acinetobacter baumannii.
Polymyxin B (PXB) and the cecropin A-melittin hybrid CA(1-8)M(1-18) (KWKLFKKIGIGAVLKVLTTGLPALIS-NH2) were compared for antibiotic activity on reference and multiresistant Acinetobacter baumannii strains. Significant differences for both peptides were observed on their inner membrane interaction and inhibition by environmental factors, supporting the use of CA(1-8)M(1-18) as a potential alternative to PXB against ACINETOBACTER:
Saugar
José María
JM
Centro de Investigaciones Biológicas (CSIC) , E-28006 Madrid, Spain.
Alarcón
Teresa
T
López-Hernández
Susana
S
López-Brea
Manuel
M
Andreu
David
D
Rivas
Luis
L
D000150:Acinetobacter / Q000187:drug effects*; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000187:drug effects; D015169:Colony Count, Microbial; D003428:Cross Infection / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006801:Humans; D008555:Melitten / Q000494:pharmacology*; D008566:Membranes / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010101:Oxygen Consumption / Q000187:drug effects; D011112:Polymyxin B / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D001425:Bacterial Outer Membrane Proteins; D008555:Melitten; C031161:cecropin A; D011112:Polymyxin B