Dermal pharmacokinetics of the insecticide furathiocarb in rats.
The pharmacokinetics of furathiocarb were studied in vivo in male Sprague-Dawley rats following dermal treatment. HPLC and post-column derivatization were used for the analysis of furathiocarb and its metabolites (carbofuran, 3-hydroxycarbofuran and 3-ketocarbofuran). Carbofuran and 3-hydroxycarbofuran were detected in plasma and urine rather than furathiocarb. 3-Ketocarbofuran, another potential metabolite, was not observed in any sample. The concentration of carbofuran was higher than that of 3-hydroxycarbofuran in plasma, but the reverse was the case in urine. The corresponding area under the plasma concentration-time curve, Tmax, and Cmax values of carbofuran and 3-hydroxycarbofuran for 1500 mg kg-1 doses were 2.4-8.0 mg equiv hml-1, 12 h and 0.1-0.4 mg equiv ml-1, respectively. T1/2 was calculated only for 3-hydroxycarbofuran (28 h). Two metabolites were excreted in a dose-dependent manner without saturation.
Liu
Kwang-Hyeon
KH
School of Agricultural Biotechnology, Seoul National University, Seodundong 103, Suwon, Kyungi 441-744, Korea.
Sung
Ha-Jung
HJ
Lee
Hae-Keun
HK
Song
Byung-Hun
BH
Ihm
Yang-Bin
YB
Kim
Kyun
K
Lee
Hye-Suk
HS
Kim
Jeong-Han
JH
D000279:Administration, Cutaneous; D000818:Animals; D019540:Area Under Curve; D001572:Benzofurans / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D002219:Carbamates / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D002235:Carbofuran / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D007306:Insecticides / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000378:metabolism*
D001572:Benzofurans; D002219:Carbamates; D007306:Insecticides; C032069:3-ketocarbofuran; C028403:3-hydroxycarbofuran; D002235:Carbofuran; C052300:deltanit