title: Human absorption and retention of polonium-210 from caribou meat.
abstract: The gastrointestinal (GI) absorption factors and the biological retention times for polonium were determined for a group of 14 volunteers--seven men and seven women--from Saskatoon, Saskatchewan, Canada. Each volunteer consumed 2.0 kg of caribou meat containing known amounts of naturally occurring 210Po. Urine and faecal samples were collected for up to 65 days after meat consumption and analysed for 210Po. The average GI absorption factor for the 14 volunteers was 56 +/- 4% (range = 31-71%), not significantly different from the ICRP value of 50%. About 3% of absorbed polonium underwent prompt excretion by the urinary pathway. The remainder was retained by the body with a half-time >100 days, compared to the ICRP value of 50 days. The effect of these findings increases the dose estimate for ingestion of 210Po in food by a factor of 1.5 to 3.5. Thus, background doses to people consuming caribou and reindeer may be higher than previously thought.
authors.affiliation: Toxicology Centre, University of Saskatchewan, Saskatoon, Canada.
authors.forename: P A
authors.initials: PA
authors.lastname: Thomas
authors.forename: I
authors.initials: I
authors.lastname: Fisenne
authors.forename: D
authors.initials: D
authors.lastname: Chorney
authors.forename: A S
authors.initials: AS
authors.lastname: Baweja
authors.forename: B L
authors.initials: BL
authors.lastname: Tracy
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000818:Animals; D005260:Female; D005507:Food Contamination, Radioactive; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008460:Meat; D008875:Middle Aged; D011059:Polonium / Q000493:pharmacokinetics*; D011834:Radiation Monitoring; D012053:Reindeer; D014018:Tissue Distribution
chemical_list: D011059:Polonium