The role of physiologically based toxicokinetic models in biologically based risk assessment.
Biologically-based cancer risk assessment relies on mathematical models that represent the toxicokinetics and toxicodynamics of the xenobiotic in the body. Physiologically-based toxicokinetic (PBTK) models are used as a tool for predicting the target tissue dose of a xenobiotic from different routes of exposure, extrapolating from high doses to low doses and extrapolating between species. This paper reviews the role of PBTK models and their limitations in biologically-based risk assessment.
Watanabe
K H
KH
Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA.
Chen
C
C
D000818:Animals; D004785:Environmental Pollutants / Q000009:adverse effects / Q000493:pharmacokinetics*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000139:chemically induced*; D010599:Pharmacokinetics; D018570:Risk Assessment / Q000379:methods*
D004785:Environmental Pollutants