Phosphoramidate-mediated conversion of carbonyl ligands into isocyanide ligands: a new approach to chiral isocyanide ligands.
Metal isocyanides have been used and studied by organometallic chemists for many years and, as a result, they have a rich and interesting chemistry. The nature of metal-free isocyanides and the methods of making isocyanide complexes, however, has resulted in the vast majority of studies to date being performed with structurally simple isocyanides. We report here a new approach to the synthesis of isocyanide ligands that involves the reaction of a metal carbonyl ligand with the anion of a phosphoramidate. As phosphoramidates can be synthesised in one step from amines, our method means that the structural diversity of readily available amines, particularly chiral amines, can now be incorporated into isocyanide ligands.
Gibson
Susan E
SE
Department of Chemistry, King's College London, UK. susan.gibson@kcl.ac.uk
Ibrahim
Hasim
H
Pasquier
Corinne
C
Peplow
Mark A
MA
Rushton
Julia M
JM
Steed
Jonathan W
JW
Sur
Surojit
S