title: [Evolution of antithrombin activity and plasma fibrinogen levels and of hematologic values among women in child-bearing age on treatment with the new hormonal oral contraceptives].
abstract: OBJECTIVE
  To study the evolution of antithrombin (AT) and plasma fibrinogen levels and of hematologic values among women in child-bearing age on treatment with the new hormonal oral contraceptives (HOC): in microdose, ultramicrodose and Diane-35.
  
  
  METHODS
  Retrospective review of 100 randomized cases out of a total registry of 1,245 clinical records.
  
  
  RESULTS
  The mean age in our series was 23.4 years (range: 18-39 years). The mean study time was 3.3 years (range: 1-5 years). During the study period, there was not a single woman with an AT lower than 70%. There were no significant changes at the end of the study period regarding AT, plasma fibrinogen, hematocrit, hemoglobin, prothrombin activity and activated partial thromboplastin time. A significant decrease was observed for platelet count (246,113 5,842 vs. 215,636 4,383 platelets/mm3; p = 0.003). There was not a single case of thrombocytopenia registered. No relevant differences were observed between the treatment groups with microdosaged, ultramicrodosaged and Diane-35.
  
  
  CONCLUSIONS
  At mid-term (3.3 years), the new HOC (in microdose, ultramicrodose and Diane-35), do not cause significant changes in AT, plasma fibrinogen, hematocrit, hemoglobin, prothrombin activity and activated partial thromboplastin time. In our series, a moderate but significant decrease in the platelet count was observed but there were no cases of thrombocytopenia. The effect of the different new HOC on the studied parameters was similar.
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario Infanta Cristina, Badajoz, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Calvo Romero
authors.forename: E M
authors.initials: EM
authors.lastname: Lima Rodríguez
authors.forename: M T
authors.initials: MT
authors.lastname: Peinado Rodríguez
authors.forename: P
authors.initials: P
authors.lastname: Bureo Dacal
authors.forename: M
authors.initials: M
authors.lastname: Pérez Miranda
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D012189:Retrospective Studies
chemical_list: D003278:Contraceptives, Oral, Hormonal