Retinal vein occlusion and factor V Leiden and prothrombin 20210 G:A mutations.
OBJECTIVE
The aim of this study was to establish whether the factor V Leiden mutation and the prothrombin 20210 G:A mutation were risk factors for retinal vein occlusion.


METHODS
Blood samples were obtained from 40 patients with retinal vein occlusion and from 50 healthy normal volunteers as controls. Polymerase chain reaction assays were done to detect factor V Leiden and prothrombin 20210 G:A mutations, and the two groups were compared.


RESULTS
Two (5%) of 40 patients with retinal vein occlusion and three (6%) of 50 controls were heterozygous for factor V Leiden (p=0.84). None of the individuals in either group had the prothrombin 20210 G:A mutation.


CONCLUSIONS
There was no significant association between retinal vein occlusion and the factor V Leiden mutation.
Aras
S
S
Department of Genetics, Başkent University, School of Medicine, Ankara, Turkey.
Yilmaz
G
G
Alpas
I
I
Baltaci
V
V
Tayanç
E
E
Aydin
P
P
D000328:Adult; D000368:Aged; D004252:DNA Mutational Analysis; D017931:DNA Primers / Q000737:chemistry; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D011516:Prothrombin / Q000235:genetics*; D012170:Retinal Vein Occlusion / Q000235:genetics*; D012307:Risk Factors
D017931:DNA Primers; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin