title: Prediction of pregnancy in infertile women with endometriosis.
abstract: To estimate the probability of pregnancy in infertile women with endometriosis, two series of multivariate analyses were performed in Tohoku University Hospital. In the first series, from 1993 to 1997, 103 patients participated. The Cox proportional hazard regression model revealed a hazard ratio of 2.43 in patients with high ovarian adhesion scores. Bilateral ovarian adhesion was an important variable in anatomical factors, probably second only to bilateral tubal adhesion. In the next series, from 1998 to 1999, 23 patients were included, and the preoperative serum concentrations of cytokines, interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-alpha were analyzed. Only TNF-alpha was selected with a forward stepwise analysis after forcing age and infertile duration. In the logistic regression model, the serum TNF-alpha level had a significant and negative impact on the likelihood of pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Tohoku University, Sendai, Japan. tm@ob-gy.med.tohoku.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Murakami
authors.forename: Chikako
authors.initials: C
authors.lastname: Okamura
authors.forename: Sachiko
authors.initials: S
authors.lastname: Matsuzaki
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Terada
authors.forename: Rei
authors.initials: R
authors.lastname: Yokomizo
authors.forename: Takahiro
authors.initials: T
authors.lastname: Noda
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yaegashi
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Okamura
mesh_terms: D000328:Adult; D016207:Cytokines / Q000096:biosynthesis* / Q000097:blood; D004715:Endometriosis / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000150:complications* / Q000175:diagnosis; D016015:Logistic Models; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011247:Pregnancy / Q000706:statistics & numerical data*; D011336:Probability; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D016207:Cytokines