title: [Certain aspects of neoadjuvant therapy of locally advanced breast cancer].
abstract: The paper presents the results of a complex investigation of patients with locally-advanced breast cancer who received neoadjuvant chemotherapy or chemoradiation at initial stage. The clinical and pathomorphological effects, nature of neoadjuvant therapy and number of courses were followed up for 5- and 10-year periods. A direct correlation was found between number of courses for chemotherapy-sensitive patients, on the one hand, and greater effect, more intensive medicinal pathomorphism and longer recurrence-free survival, particularly, at later stages, on the other.
authors.affiliation: Russian Center for Roentgeno-Radiology Research, Ministry of Health of the RF, Moscow.
authors.forename: E K
authors.initials: EK
authors.lastname: Voznyĭ
authors.forename: S N
authors.initials: SN
authors.lastname: Gurov
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Dobrovol'skaia
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020360:Neoadjuvant Therapy; D013997:Time Factors