Effects of long-term renal sympathetic denervation on heart failure after myocardial infarction in rats.
The purpose of the present study was to investigate the effects of long-term renal denervation (RD) on heart failure due to myocardial infarction (MI). Wistar rats were anesthetized and the bilateral renal nerves were surgically denervated 2 days before MI was induced by coronary artery ligation. Four weeks later, left ventricular (LV) function and sodium excretion were determined. In MI rats, RD improved the reduced sodium excretion. MI + RD rats revealed lower LV end-diastolic pressure and greater maximum dP/dt as compared with those of MI+ innervation (INN) rats. LV end-diastolic and end-systolic dimensions were significantly smaller and LV fractional shortening was greater in MI + RD rats than in MI + INN rats (20.9% +/- 3.2% vs 14.9% +/- 3.0%). In rats without MI, RD did not affect either sodium excretion or LV function and dimensions. The present results suggest that the long-term RD reduces LV filling pressure and improves LV function after MI, probably due to a restoration of impaired natriuresis. Increased renal sympathetic nerve activity might contribute to the progression of heart failure after MI.
Nozawa
Takashi
T
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Igawa
Akihiko
A
Fujii
Nozomu
N
Kato
Bun-ichi
B
Yoshida
Naohiro
N
Asanoi
Hidetsugu
H
Inoue
Hiroshi
H
D000818:Animals; D003326:Coronary Circulation; D003331:Coronary Vessels; D004195:Disease Models, Animal; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology*; D006439:Hemodynamics; D007668:Kidney / Q000294:innervation*; D008026:Ligation; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000209:etiology / Q000503:physiopathology; D009318:Natriuresis; D051381:Rats; D017208:Rats, Wistar; D013153:Splanchnic Nerves; D013562:Sympathectomy; D013997:Time Factors; D016277:Ventricular Function, Left