Molecular design and biological potential of galacto-type trehalose as a nonnatural ligand of shiga toxins.
Galacto-type trehalose, a "C-4 epimer of trehalose", possesses a stereochemical structure around the alpha(1-1)-linkage analogous to that of the globobiosyl alpha(1-4)-linkage in Gb(2) and Gb(3) ceramides, which are known as the ligands of Shiga toxins produced by pathogenic E. coli. This paper presents evidence supporting the new idea of using a trehalosyl alpha(1-1)-linkage as a substitute for the galactobiosyl alpha(1-4)-linkage.
Dohi
Hirofumi
H
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan.
Nishida
Yoshihiro
Y
Furuta
Yuki
Y
Uzawa
Hirotaka
H
Yokoyama
Shin-ichiro
S
Ito
Saori
S
Mori
Hiroshi
H
Kobayashi
Kazukiyo
K
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D005690:Galactose / Q000737:chemistry*; D006386:Hemagglutination Tests; D008024:Ligands; D008958:Models, Molecular; D022621:Shiga Toxin / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D014199:Trehalose / Q000737:chemistry / Q000378:metabolism*
D008024:Ligands; D022621:Shiga Toxin; D014199:Trehalose; D005690:Galactose