Suppression of atrial tachyarrhythmias by pacing.
BACKGROUND
Treatment of atrial tachyarrhythmias (ATs) remains difficult in many patients. Accordingly, new therapeutic approaches for AT suppression are evaluated. Atrial pacing may prevent ATs by modifying the electrophysiologic conditions required for sustained ATs.


RESULTS
New pacing algorithms for prevention of AT are aimed at permanent overdrive suppression of arrhythmic activity, reduction of dispersion of atrial refractoriness produced by short-long cycles, more aggressive overdrive pacing after spontaneous sinus conversion to prevent early reinitiation of ATs, and prevention of inadequate rate decay in patients with vagally induced ATs. AT prevention may be achieved by dedicated atrial pacing sites, e.g., pacing at the insertion of Bachmann's bundle or biatrial pacing, which compensates for interatrial conduction delay. Preexciting regions of critical conduction delay, pacing at the triangle of Koch or coronary sinus os, and dual-site right atrial pacing have shown antiarrhythmic effects. Atrial preventive pacing and pharmacologic treatment may work synergistically in the concept of hybrid therapy. To prevent atrial electrical remodeling, early termination of AT seems desirable. This may be achieved by implanted devices that automatically detect ATs and provide atrial antitachycardia pacing for organized ATs. Initial studies showed that regular AT can automatically be terminated in approximately 50% of treated episodes.


CONCLUSIONS
Pacing for prevention of AT and termination of organized AT episodes may become important steps within the concept of hybrid therapy of AT. However, their clinical efficacy and optimal patient selection remain to be evaluated in prospective, well-designed clinical trials.
Israel
Carsten W
CW
Department of Medicine, J.W. Goethe University, Frankfurt, Germany.
Grönefeld
Gerian
G
Ehrlich
Joachim R
JR
Hohnloser
Stefan H
SH
D000465:Algorithms; D001281:Atrial Fibrillation / Q000503:physiopathology / Q000628:therapy; D002304:Cardiac Pacing, Artificial; D003131:Combined Modality Therapy; D006329:Heart Conduction System / Q000502:physiology; D006352:Heart Ventricles; D006801:Humans; D010138:Pacemaker, Artificial; D013612:Tachycardia, Ectopic Atrial / Q000517:prevention & control / Q000628:therapy*