title: Renin producing neuroendocrine pancreatic carcinoma--a case report and review of the literature.
abstract: A 44 year old male patient presented with severe hypertension. The diagnostic work-up revealed elevated levels of plasma renin activity (about 10 times the upper limit of normal) in the presence of normal plasma aldosterone levels and serum potassium concentrations. Renovascular disease was excluded by angiography. Selective renal vein sampling did not show any renin gradient. CT-scans of the abdomen demonstrated normal morphology of the kidneys and adrenals but revealed a big mass in the pancreatic corpus and tail with infiltration of the splenic vein and the presence of enlarged local lymph nodes. The endocrine nature of the pancreatic mass was further supported by a positive octreotide scintigraphy scan. Surgical removal of the tumor by left sided pancreatectomy combined with splenectomy resulted in rapid normalization of elevated renin concentrations as well as blood pressure. Histological examination of the tumor tissue revealed the presence of a neuroendocrine pancreatic carcinoma. Highly (x 70) elevated renin levels were detected by radioimmunoassay in the tumor tissue. To our knowledge this is the first renin-producing neuroendocrine pancreatic carcinoma described in the literature. The present paper describes the case in detail and reviews the available literature on clinical symptomatology, diagnosis and treatment of renin-producing tumors.
authors.affiliation: Department of General Surgery, University Hospital, Philipps-University of Marburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Langer
authors.forename: D
authors.initials: D
authors.lastname: Bartsch
authors.forename: B
authors.initials: B
authors.lastname: Gerdes
authors.forename: I
authors.initials: I
authors.lastname: Schwetlick
authors.forename: A
authors.initials: A
authors.lastname: Wild
authors.forename: B
authors.initials: B
authors.lastname: Brehm
authors.forename: C
authors.initials: C
authors.lastname: Erley
authors.forename: R
authors.initials: R
authors.lastname: Lamberts
mesh_terms: D000328:Adult; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D008297:Male; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D011877:Radionuclide Imaging; D012083:Renin / Q000096:biosynthesis*; D013156:Splenectomy; D014057:Tomography, X-Ray Computed
chemical_list: D012083:Renin