The first intermolecular Friedel-Crafts acylation with beta-lactams.
The first intermolecular Friedel-Crafts acylation of a variety of aromatic substrates with azetidinones is described. The Friedel-Crafts acylations are performed under very mild conditions, using trifluoromethanesulfonic acid to produce beta-amino aromatic ketones in excellent yields.
Anderson
Kevin W
KW
Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA.
Tepe
Jetze J
JJ