title: Genomics approaches to drug discovery.
abstract: New approaches to drug discovery have come about in recent years as a result of important advances in genomics and bioinformatics. The availability of genome-scale sequence data, the development of new tools for high-throughput gene expression monitoring, and improvements in the ability to analyze large data sets have revolutionized the field. In this article, we discuss three applications of genomics data in the drug discovery process: target discovery, prodrug strategies, and vaccine development.
authors.affiliation: Department of Genomic and Information Sciences, Hoffmann-La Roche Inc., Nutley, New Jersey 07110-1199, USA. john.reidhaar-olson@roche.com
authors.forename: J F
authors.initials: JF
authors.lastname: Reidhaar-Olson
authors.forename: B K
authors.initials: BK
authors.lastname: Rhees
authors.forename: J
authors.initials: J
authors.lastname: Hammer
mesh_terms: D000595:Amino Acid Sequence; D019295:Computational Biology / Q000379:methods; D016503:Drug Delivery Systems; D015195:Drug Design; D020869:Gene Expression Profiling / Q000379:methods*; D023281:Genomics / Q000379:methods*; D008969:Molecular Sequence Data; D011355:Prodrugs; D011743:Pyrimidines; D014612:Vaccines
chemical_list: C097286:H 0294; D011355:Prodrugs; D011743:Pyrimidines; D014612:Vaccines