[Allotransplantation of cultured fetal parathyroid gland cells in treating patients with hypoparathyroidism].
OBJECTIVE
To evaluate the therapeutic efficacy of transplantation of cultured human fetal parathyroid gland (chf-PTG) cells in treating patients with primary or secondary hypoparathyroidism.


METHODS
Chf-PTG cells were allotransplanted into the renal adipose capsules of 6 patients with hypoparathyroidism under the ultrasonic guidance. The levels of serum parathyroid hormone (PTH) and calcium were monitored by radioimmunometric assay (RIA) and biochemical method, respectively. Both indexes of pre-and post-operation were compared and the data were analyzed.


RESULTS
The levels of serum PTH and calcium were markedly elevated from three days to the first two weeks following transplantation of chf-PTG cells (P < 0.01). The PTH and calcium levels gradually stabilized from day 14 up to months 9-12, during which the symptoms of the patients alleviated or relieved.


CONCLUSIONS
The transplantation of chf-PTG cells is a potential method for treating patients with primary or secondary hypoparathyroidism.
Song
C
C
Department of General Surgery, First Hospital, Harbin Medical University, Harbin 150001, China.
Song
Y
Y
Wu
L
L
Ma
B
B
Duan
X
X
Pan
S
S
Song
C
C
D000328:Adult; D002118:Calcium / Q000097:blood; D017690:Cell Transplantation / Q000379:methods*; D002478:Cells, Cultured; D005260:Female; D005333:Fetus; D005500:Follow-Up Studies; D006801:Humans; D007011:Hypoparathyroidism / Q000097:blood / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands; D010281:Parathyroid Hormone / Q000097:blood; D011863:Radioimmunoassay; D014184:Transplantation, Homologous; D016896:Treatment Outcome
C470125:PTH protein, human; D010281:Parathyroid Hormone; D002118:Calcium