title: Elements in autopsy liver tissue samples from Greenlandic Inuit and Danes. III. Zinc measured by X-ray fluorescence spectrometry.
abstract: The aim of the study was to measure the content of zinc (Zn) in liver tissue samples from Greenlandic Inuit using X-ray fluorescence spectrometry, and compare the results with those obtained in liver samples from Danes. Normal liver tissue samples was obtained at autopsy from 50 Greenlandic Inuit (27 men) with a median age of 61 years (range 23-83) and from 74 Danes (44 men) with a median age of 60 years (range 15-87). In the entire series, liver zinc content in Inuit was not significantly different compared with Danes. There was no significant gender difference in liver zinc content either in Inuit or in Danes. The content of zinc given as median (5-95 percentile) was in Inuit 3.809 mmol/kg dry liver (2.355-7.406), and in Danes 3.992 mmol/kg dry liver (2.499-8.645). There was a significant, positive correlation between liver zinc content and age in Danish women (r(s) = 0.43, p = 0.02), which could not be demonstrated in Danish men or in Inuit. Median hepatic zinc index (zinc content in mmol/kg dry weight divided by age in years) in Inuit was 0.073, and in Danes 0.080 (p = 0.3) without any significant difference between the two genders. In Inuit and Danes there was an inverse correlation between hepatic zinc index and age both in the two genders and in the entire series: Inuit: r(s) = -0.62, p < 0.0001; Danes: r(s) = -0.70, p < 0.0001. The results indicate that Inuit have liver zinc levels, which are similar to those found in Danes.
authors.affiliation: Department of Mathematics and Physics, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Laursen
authors.forename: N
authors.initials: N
authors.lastname: Milman
authors.forename: H S
authors.initials: HS
authors.lastname: Pedersen
authors.forename: G
authors.initials: G
authors.lastname: Mulvad
authors.forename: H
authors.initials: H
authors.lastname: Saaby
authors.forename: K E
authors.initials: KE
authors.lastname: Byg
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D003718:Denmark; D005260:Female; D006801:Humans; D004930:Inuit; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013053:Spectrophotometry; D014965:X-Rays; D015032:Zinc / Q000378:metabolism*
chemical_list: D015032:Zinc