title: Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis.
abstract: In homozygous sickle cell disease (SCD), decreased serum Vitamin E is present. Excessive transfusions may lead to iron overload. We hypothesised a relationship between the two and found that Vitamin E type antioxidant capacity was significantly lower in 30 SCD patients than in 30 age- and sex-matched controls (P < 0.001). Antioxidant capacity was lower in 10 transfused patients compared with 20 non-transfused patients (P < 0.001). Transfusional iron overload in SCD may increase the potential for oxidative damage, and low antioxidant capacity may compound this effect.
authors.affiliation: Department of Haematology, City Hospital Trust, Birmingham, United Kingdom. sukhjinder.marwah@cityhospbham.wmids.nhs.uk
authors.forename: S S
authors.initials: SS
authors.lastname: Marwah
authors.forename: A D
authors.initials: AD
authors.lastname: Blann
authors.forename: C
authors.initials: C
authors.lastname: Rea
authors.forename: J D
authors.initials: JD
authors.lastname: Phillips
authors.forename: J
authors.initials: J
authors.lastname: Wright
authors.forename: D
authors.initials: D
authors.lastname: Bareford
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000628:therapy; D000975:Antioxidants / Q000032:analysis*; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D019190:Iron Overload / Q000097:blood / Q000209:etiology; D008297:Male; D018384:Oxidative Stress; D065227:Transfusion Reaction; D014810:Vitamin E / Q000097:blood*
chemical_list: D000975:Antioxidants; D014810:Vitamin E