Suppression of vagal motor activities evokes laryngeal afferent-mediated inhibition of gastric motility.
We previously reported that the activation of water-responsive afferents in the superior laryngeal nerve was responsible for the inhibition of gastric motility. The present study was undertaken to clarify the roles of the vagal preganglionic neurons responsible for laryngeal afferent-mediated inhibition of gastric motility. Intravenous injection of atropine abolished the inhibition of motility in both the distal and the proximal stomach induced by water administration into the larynx. The neurons in the dorsal motor nucleus of the vagus (DMV), which project to the abdominal viscera, were exclusively inhibited by water administration. Taken together, inhibition of neurons in the DMV induces inhibition of gastric motility evoked by laryngeal water-responsive afferents via a cholinergic pathway. Because chemical lesions of the intermediate DMV, but not the caudal DMV, abolished the inhibition of the distal stomach motility induced by water administration, the intermediate DMV is responsible for the inhibition shown in the distal stomach.
Kobashi
Motoi
M
Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 - 8525, Japan. mkobashi@md.okayama-u.ac.jp
Koga
Tomoshige
T
Mizutani
Masatoshi
M
Matsuo
Ryuji
R
D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D002799:Cholinergic Fibers / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology*; D007275:Injections, Intravenous; D007823:Laryngeal Nerves / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D018727:Muscarinic Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014630:Vagus Nerve / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D014867:Water / Q000494:pharmacology
D018727:Muscarinic Antagonists; D014867:Water; D001285:Atropine