title: A new biologically active triterpenoid saponin from the leaves of Lepidagathis hyalina Nees.
abstract: A new biologically active triterpenoid saponin m.f. C42H68O13, m.p. 315 degrees-317 degrees C was isolated from the ethyl acetate soluble fraction of the methanolic extract of the leaves of Lepidagathis hyalina. Its structure was characterized as 3-beta-O-[alpha-L-rhamnopyranosyl(1-->4)O-beta-D-glucopyranosyl]16-alpha-hydroxy-olean-12-en(13)-28-oic acid by several spectral and chemical analysis. This new triterpenoid saponin showed antimicrobial activity against various plants pathogenic bacteria and fungi.
authors.affiliation: Department of Chemistry, Dr. H.S. Gour University, Sagar, India.
authors.forename: R N
authors.initials: RN
authors.lastname: Yadava
mesh_terms: D027901:Acanthaceae / Q000737:chemistry*; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016282:Aspartic Acid Endopeptidases / Q000378:metabolism; D001230:Aspergillus / Q000187:drug effects; D001407:Bacillus / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D006868:Hydrolysis; D007194:India; D007709:Klebsiella / Q000187:drug effects; D008515:Medicine, Ayurvedic; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010407:Penicillium / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011511:Proteus / Q000187:drug effects; D012233:Rhizopus / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013210:Staphylococcus / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C447179:3-beta-O-(alpha-L-rhamnopyranosyl(1-4)O-beta-D-glucopyranosyl)16-alpha-hydroxy-olean-12-en(13)-28-oic acid; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D012503:Saponins; D014315:Triterpenes; D009828:Oleanolic Acid; D016282:Aspartic Acid Endopeptidases; C022772:Aspergillus oryzae carboxyl proteinase