title: Detection of Helicobacter pylori antigen in faeces by enzyme immunoassay.
abstract: The detection of Helicobacter pylori antigen directly in faecal specimens may offer an alternative non-invasive method for determining the presence of H. pylori infection. This study compared the performance of the Premier Platinum HpSA enzyme immunoassay (HpSA) with histology and CLOtest, a rapid urease test. Of 134 patients undergoing upper gastrointestinal endoscopy, 37 (28%) were H. pylori-positive by histology and CLOtest. Using the HpSA test, H. pylori was detected in 35 H. pylori-positive patients (95% sensitivity) and one H. pylori-negative patient (99% specificity). The positive and negative predictive values for HpSA were 97 and 98%, respectively. HpSA is a rapid, easily performed, non-invasive method for detecting H. pylori.
authors.affiliation: Department of Microbiology and Infectious Diseases, Royal Perth Hospital, WA, Australia. geoffrey.coombs@health.wa.gov.au
authors.forename: G W
authors.initials: GW
authors.lastname: Coombs
authors.forename: N M
authors.initials: NM
authors.lastname: Foster
authors.forename: J W
authors.initials: JW
authors.lastname: Pearman
authors.forename: G M
authors.initials: GM
authors.lastname: Forbes
mesh_terms: D000942:Antigens, Bacterial / Q000032:analysis*; D001706:Biopsy; D016145:Endoscopy, Digestive System; D005243:Feces / Q000382:microbiology*; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000201:enzymology / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007124:Immunoenzyme Techniques; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014510:Urease / Q000032:analysis
chemical_list: D000942:Antigens, Bacterial; D014510:Urease