Cancer chemopreventive effects of constituents of Caesalpinia ferrea and related compounds.
The anti-tumor promoting effects of fruits of Caesalpinia ferrea MART. (Leguminosae) were tested by the in vitro Epstein-Barr virus early antigen (EBV-EA) activation assay, and its active constituents were identified as gallic acid (1) and methyl gallate (2). A total of 49 related compounds of 1 and 2 were analysed for the effects by this assay, and the structure activity relationships have been proposed. Three acetophenone derivatives, 2,6-dihydroxyacetophenone (48), 2,3,4-trihydroxyacetophenone (50) and 2,4,6-trihydroxy- acetophenone (51) were found to show potent inhibitory activity.
Nakamura
Eliane S
ES
Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0194, Japan.
Kurosaki
Fumiya
F
Arisawa
Munehisa
M
Mukainaka
Teruo
T
Okuda
Masato
M
Tokuda
Harukuni
H
Nishino
Hoyoku
H
Pastore
Floriano
F
D000956:Antigens, Viral / Q000187:drug effects* / Q000378:metabolism; D001681:Biological Assay; D029911:Caesalpinia; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D008517:Phytotherapy; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D028321:Plant Preparations; C052082:methyl gallate; D005707:Gallic Acid