Of mice and worms: novel insights into ClC-2 anion channel physiology.
ClC anion channels are found in all major groups of organisms. Recent studies in nematodes and mice suggest that the function and regulation of ClC-2 have been conserved over vast evolutionary time spans. These studies illustrate the experimental advantages of using genomically defined nonmammalian model organisms for characterizing ClC channel functional genomics.
Strange
Kevin
K
Anesthesiology Research Division, Laboratory of Cellular Physiology, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
D000818:Animals; D000090007:CLC-2 Chloride Channels; D017173:Caenorhabditis elegans / Q000378:metabolism; D018118:Chloride Channels / Q000502:physiology*; D051379:Mice / Q000378:metabolism
D000090007:CLC-2 Chloride Channels; D018118:Chloride Channels