title: Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs?
abstract: Alzheimer disease (AD) is defined pathologically and diagnostically defined by amyloid-beta senile plaques and neurofibrillary tangles (NFT) composed of tau. From the time of their original description nearly a century ago, a major focus has been to understand the role that these lesions play in the pathogenesis of the disease. The majority favors the notion that these lesions cause the disease and therefore attempts at therapeutic intervention are focused on preventing lesions formation. However, this rationale may be misguided since new evidence from our laboratories and others suggest that the lesions not only occur as a by-product of the fundamental disease process but also that they may be protective.
authors.affiliation: Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA. mas21@po.cwru.edu
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Drew
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nunomura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeda
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hirai
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zhu
authors.forename: Craig S
authors.initials: CS
authors.lastname: Atwood
authors.forename: Arun K
authors.initials: AK
authors.lastname: Raina
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Rottkamp
authors.forename: Lawrence M
authors.initials: LM
authors.lastname: Sayre
authors.forename: Robert P
authors.initials: RP
authors.lastname: Friedland
authors.forename: George
authors.initials: G
authors.lastname: Perry
mesh_terms: D000375:Aging / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001057:Apolipoproteins E / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology*; D018384:Oxidative Stress / Q000502:physiology; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D016875:tau Proteins