Effect of Calcium Entry Blocking Agents (Nifedipine and Verapamil) on Myocardial Recovery during Reperfusion.
A comparative study on isolated guinea pig hearts was carried out to determine the effect of calcium entry blocking agents: nifedipine- and verapamil-added reperfusion solutions on myocardial recovery after global ischemia. After 20 min of normothermic ischemia, three groups of solutions were used for reperfusion (10 animals each): (1) Nifedipine-added (10--8 mmol L(minus sign1)) Krebs--Henseleit solution; (2) verapamil-added (10--8 mmol L(minus sign)) Krebs-Henseleit solution; (3) Krebs--Henseleit solution. Postischemic myocardial functions (ventricular contractile force and heart work) and enzyme activities were compared with their preischemic values. The addition of calcium entry blocking agents does not have any significant advantage over control solutions in myocardial recovery.
Gökgöz
Levent
L
Gazi University, School of Medicine Ankara, Turkey.
Gunaydin
Serdar
S
Tatlican
Oguz
O
Babacan
Avni
A
Halit
Velit
V
Oğuz
Aydin
A
Cevik
Cemal
C
Aydin
Hakan
H
Yavuz
Ozlem
Soncul
Halim
H