The conventional doses of human chorionic gonadotropins may not always be sufficient to induce ovulation in all women: a reappraisal.
BACKGROUND
Failure of ovulation has occasionally been reported following the administration of conventionally recommended doses of exogenous human chorionic gonadotropins.


METHODS
A 25-year-old nulliparous woman with polycystic ovary syndrome underwent ovulation induction for primary infertility. Following successful ovarian stimulation, she failed to ovulate during two consecutive cycles in response to human chorionic gonadotropin doses of 5,000 and 10,000 IU. When challenged with a higher than conventional dose (15,000 IU) on the third cycle, she ovulated and conceived.


CONCLUSIONS
Conventional doses of exogenous human chorionic gonadotropins occasionally fail to complete the ovulatory process in some women. Women with polycystic ovary syndrome appear to be particularly susceptible. Routine documentation of ovulation and individualization of the dose of exogenous human chorionic gonadotropins could therefore prove to be useful in some of these women in order to achieve the best treatment outcome.
Awwad
J T
JT
Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Lebanon.
Farra
C G
CG
Awwad
S T
ST
Bu-Habib
R M
RM
Abdallah
M A
MA
Usta
I M
IM
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology
D006063:Chorionic Gonadotropin