The release of diazepam from poly(hydroxybutyrate-hydroxyvalerate) microspheres.
Microspheres based on a poly(hydroxybutyrate-hydroxyvalerate) copolymer (PHBV) (Mw = 630kD, 21% mol HV) were loaded with diazepam using different emulsion-solvent evaporation processes. Gelatin was used as a strategy to alter the release profile of the incorporated drug. The mean diameter of microspheres was from 30-40 micron. Drug-release from the microspheres over a 30-day period showed a characteristic triphasic release pattern with an initial burst effect, but was linear over the same period and without a burst effect when gelatin was used as a coating agent. Scanning electron microscopy revealed that the microspheres had different structures depending upon their method of preparation.
Chen
J
J
Department of Pharmaceutical Sciences, Nanfang Hospital, The First Medical University of PLA, TongHe, Guangzhou, PR China.
Davis
S S
SS
D003692:Delayed-Action Preparations / Q000493:pharmacokinetics; D003975:Diazepam / Q000493:pharmacokinetics*; D004339:Drug Compounding / Q000379:methods*; D005780:Gelatin; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011091:Polyesters; D000094122:Polyhydroxybutyrates
D003692:Delayed-Action Preparations; D003975:Diazepam; D005780:Gelatin; D011091:Polyesters; C052620:poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate); D000094122:Polyhydroxybutyrates