One-pot preparation of chiral beta-amino esters by rhodium-catalyzed three-components coupling reaction.
Chiral beta-amino esters are synthesized in one-pot from three components, amines, aldehydes, and ethyl bromoacetate, under the rhodium-catalyzed Reformatsky-type reaction condition, where complete diastereoselection is achieved in the nucleophilic addition step of ethyl bromoacetate to the imines prepared in
Honda
Toshio
T
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. honda@hoshi.ac.jp
Wakabayashi
Hitoshi
H
Kanai
Kazuo
K
D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D012238:Rhodium / Q000494:pharmacology; D013237:Stereoisomerism
D000596:Amino Acids; D012238:Rhodium