title: New and antifungal xanthones from Calophyllum caledonicum.
abstract: Two new xanthones, namely caledonixanthones E (1) and F (2), were isolated from the stem bark of Calophyllum caledonicum (Guttiferae). The structural elucidation of these compounds was mainly established on the basis of 1D, 2D NMR and HRMS spectroscopic analysis. Among the isolated compounds, eight other known xanthones were also identified in the course of this phytochemical study. In addition to this report, a preliminary evaluation of the antifungal properties of these polyphenolic compounds against Aspergillus fumigatus and Candida albicans is presented.
authors.affiliation: SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la santé, 16, Bd Daviers, Angers, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Morel
authors.forename: Denis
authors.initials: D
authors.lastname: Séraphin
authors.forename: Agnès
authors.initials: A
authors.lastname: Teyrouz
authors.forename: Gérald
authors.initials: G
authors.lastname: Larcher
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Bouchara
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Pascal
authors.initials: P
authors.lastname: Richomme
authors.forename: Jean
authors.initials: J
authors.lastname: Bruneton
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D029759:Calophyllum; D002176:Candida albicans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D044004:Xanthones
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts; D014966:Xanthenes; D044004:Xanthones; C452872:caledonixanthone E; C452871:caledonixanthone F