[Combination therapy including mutamycin (mitomycin C) in the treatment of advanced colorectal and gastric cancer].
The paper reports the data on treatment of 57 patients with disseminated gastric and colorectal carcinoma using a combination of mutamycin + 5-fluorouracil + leucovorin + cisplatin. Overall response was 26.3% including complete--7.01 and partial--19.29%. Mean duration of complete and partial remission was 10.88 +/- 5.65 and 5.18 +/- 0.82 months, respectively. Treatment as first-line chemotherapy was significantly more effective (36.1 and 9.5%). The regimens proved relatively low-toxic and therefore, can be recommended for out-patient application.
Manziuk
L V
LV
N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.
Artamonova
E V
EV
Sholokhov
V N
VN
Strygina
E A
EA
D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage* / Q000009:adverse effects; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D010045:Outpatients; D013274:Stomach Neoplasms / Q000188:drug therapy*; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D016685:Mitomycin; D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil