[The level of expression of adhesion molecules CD44v6 and E-cadherin in colorectal cancer and analysis of correlates with metastasis].
OBJECTIVE
To determine the expression of adhesion molecules CD44v6 and E cadherin in colorectal cancer and its relation with metastasis.


METHODS
The expression of CD44v6 and E-cadherin in 32 patients with colorectal carcinoma was investigated using immunohistochemical staining, which was performed on surgical specimens.


RESULTS
No significant correlation with CD44v6 and histologic type, TNM and Dukes staging was noted, but it was significantly correlated with lymph node and hematogenous metastasis. E-cadherin was strongly expressed in normal epithelium examined. However, E-cadherin expression in colorectal carcinoma was reduced (positive rate 46.9%). Metastatic colorectal carcinoma showed significant reduction (positive rate 20%).


CONCLUSIONS
CD44v6, E-cadherin immunoreactivity are significantly correlated with lymph node and hematogenous metastasis.
Gu
J
J
Department of Surgery, People's Hospital, Beijing Medical University, Beijing 100044.
Zhu
X
X
Ye
Y
Y
Qu
J
J
Huang
L
L
Li
R
R
Yu
Y
Y
Leng
X
X
D015820:Cadherins / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis
D015820:Cadherins; D018960:Hyaluronan Receptors