title: Is it possible to detect ulcerative colitis-related respiratory syndrome early?
abstract: OBJECTIVE
  Obstructive airway disease, bronchiectasis, non-specific parenchymal infiltration and bronchiolitis obliterans organizing pneumonia are seen occasionally in patients with inflammatory bowel disease. In the present study, we evaluated ulcerative colitis (UC) patients for latent pulmonary involvement.
  
  
  METHODS
  Fifteen patients (nine females, six males, mean age 44 years) were admitted into the study. All patients were free of respiratory symptoms. Ulcerative colitis was active in nine patients and all patients were using anti-inflammatory treatment. Pulmonary function tests (PFT), high resolution computed tomography of thorax (HRCT) and bronchoscopy with bronchoalveolar lavage (BAL) and transbronchial biopsy (TBLB) were carried out in all subjects.
  
  
  RESULTS
  Mild airways obstruction was found in 1 of 13 patients. High resolution CT was abnormal in 4 of 15 patients. Ground glass appearance suggestive of an interstitial lung disease was present in three patients. Radiolucency and pneumocysts were present in the fourth patient suggesting obstructive small airway disease. High resolution CT findings correlated with disease activity (P < 0.05). Fiberoptic bronchoscopy was performed in 10 patients. A mixed type alveolitis was detected in BAL fluid in five patients. In eight patients, TBLB showed alveolar septal thickening by connective tissue, lymphocytic accumulation in the septal area and minimal septal fibrosis, suggesting subclinical pulmonary parenchymal involvement linked to UC.
  
  
  CONCLUSIONS
  Our data suggest that latent interstitial pulmonary involvement may occur during the course of UC, despite an absence of symptoms of lung disease.
authors.affiliation: Department of Chest Diseases, Ege University Medical Faculty, Izmir, Turkey. fisunkaradag@yahoo.com
authors.forename: F
authors.initials: F
authors.lastname: Karadag
authors.forename: M H
authors.initials: MH
authors.lastname: Ozhan
authors.forename: E
authors.initials: E
authors.lastname: Akçiçek
authors.forename: O
authors.initials: O
authors.lastname: Günel
authors.forename: H
authors.initials: H
authors.lastname: Alper
authors.forename: A
authors.initials: A
authors.lastname: Veral
mesh_terms: D000328:Adult; D001706:Biopsy; D018893:Bronchoalveolar Lavage; D001999:Bronchoscopy; D003093:Colitis, Ulcerative / Q000150:complications*; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000209:etiology*; D008297:Male; D011446:Prospective Studies; D012129:Respiratory Function Tests; D012907:Smoking / Q000453:epidemiology; D014057:Tomography, X-Ray Computed