Development and evaluation of matrix and two layered sustained release suppositories of theophylline.
Theophylline loaded conventional suppositories, sustained release matrix suppositories and sustained release two layered suppositories were prepared using polyethylene glycol 4000 and eudragit RS-100 and their characteristics were evaluated both in-vitro and in-vivo. In comparison to conventional suppositories, the release of the drug from sustained release matrix suppositories was gradual and extended over a period of time. On the other hand two layered suppositories produced an initial quick release followed by extended release of the drug. The in-vivo results were found to correlate with the in-vitro results.
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Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
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Bandyopadhyay
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D000818:Animals; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations; D005079:Excipients; D008297:Male; D011817:Rabbits; D012995:Solubility; D013488:Suppositories; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry*
D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D005079:Excipients; D013488:Suppositories; D013806:Theophylline