[Changes in mammography and breast ultrasonography in women undergoing hormonal replacement therapy].
OBJECTIVE
The aim of this study was to compare changes in mammography and breast ultrasonography in women undergoing Hormonal Replacement Therapy (HRT) and a control group.


METHODS
Retrospective analysis of clinical documentation form 12.1998 to 11.1999 of 1075 women over 45 years old. COLLECTED DATA INCLUDED: Breast imaging, hormonal therapy, gynecological, obstetrical and oncological interview and examination. Analysis was performed using MS Access DataBase and Statistica v5.0, p = 0.05 was considered significant.


RESULTS
710 women were actually undergoing HRT and 365 were qualified to the control group. Oral HRT was used by 72.2% women, transcutaneous by 24.1% and transvaginal by 3.7%. There were no differences of breast cancer risk factors, age and cancer suspicious changes (relative risk 1.03) in analyzed groups. Suspicious microcalcifications were rarer in women undergoing HRT (relative risk 0.49) while breast cysts (especially to 0.5 cm) were more frequent. There were no statistically significant differences in other changes like: benign breast masses, macrocalcifications and mastopathy. All findings referred to superiolateral quadrant in 50% of HRT women and 56% of control group.


CONCLUSIONS
Hormonal Replacement Therapy has no marked influence on changes in mammography and ultrasonography. Among women undergoing HRT, microcysts are more frequent while suspicious microcalcifications are less.
Rzymski
P
P
Katedr Ginekologii i Połoznictwa AM w Poznaniu.
Szpakowska-Rzymska
I
I
Wilczak
M
M
Warenik-Szymankiewicz
A
A
Sajdak
S
S
D001940:Breast / Q000187:drug effects* / Q000473:pathology*; D001941:Breast Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000473:pathology; D001943:Breast Neoplasms / Q000139:chemically induced / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000139:chemically induced; D016022:Case-Control Studies; D003560:Cysts / Q000139:chemically induced / Q000473:pathology; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D017698:Postmenopause; D012189:Retrospective Studies; D014463:Ultrasonography