title: Emc, a negative HLH regulator with multiple functions in Drosophila development.
abstract: Expression and functional analyses of Emc have demonstrated that it is a prototype for a protein required for multiple processes in development. Initially characterized as a negative regulator of sensory organ development, it was later found to regulate many other developmental processes and cell proliferation. Its ability to block the function of bHLH proteins by forming heterodimers, which are ineffective in DNA binding, accounts for the role of Emc in preventing the acquisition of several cell fates which are under the control of bHLH proteins. However, while maintaining this repressive molecular mechanism, emc also appears to act as a positive regulator of differentiation.
authors.affiliation: Centro de Biología Molecular Severo Ochoa, Cantoblanco, 28049 Madrid, Spain. scampuzano@cbm.uam.es
authors.forename: S
authors.initials: S
authors.lastname: Campuzano
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002455:Cell Division; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D019281:Dimerization; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D004625:Embryo, Nonmammalian / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000235:genetics / Q000502:physiology; D004817:Epidermis / Q000196:embryology / Q000294:innervation; D005123:Eye / Q000196:embryology / Q000254:growth & development; D005136:Eye Proteins / Q000235:genetics / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology*; D018257:Helix-Loop-Helix Motifs; D051796:Inhibitor of Differentiation Proteins; D007814:Larva; D008317:Malpighian Tubules / Q000196:embryology / Q000254:growth & development; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009024:Morphogenesis / Q000235:genetics / Q000502:physiology; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology; D012097:Repressor Proteins; D012679:Sense Organs / Q000196:embryology / Q000502:physiology; D014132:Trachea / Q000196:embryology / Q000254:growth & development; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D014921:Wings, Animal / Q000098:blood supply
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D005136:Eye Proteins; D051796:Inhibitor of Differentiation Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C090080:Da protein, Drosophila; C089199:ac protein, Drosophila; C063577:emc protein, Drosophila; C089197:sc protein, Drosophila; C075640:ID3 protein, human