Turning on the Arp2/3 complex at atomic resolution.
The recently published 2 A X-ray crystal structure of bovine Arp2/3 complex gives us atomic scale insight into Arp2/3-mediated actin nucleation, while cryo-EM work and functional studies begin to fill in exciting mechanistic details.
Borths
Elizabeth L
EL
Department of Chemistry, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
Welch
Matthew D
MD
D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins / Q000737:chemistry* / Q000648:ultrastructure; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003598:Cytoskeletal Proteins; D046911:Macromolecular Substances; D008958:Models, Molecular; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins; D003598:Cytoskeletal Proteins; D046911:Macromolecular Substances; D000255:Adenosine Triphosphate