[Effects of polymorphism of apolipoprotein E gene on body mass index and plasma lipid levels in obese children].
OBJECTIVE
To investigate the association between body mass index (BMI) and plasma lipid levels in obese children with different apolipoprotein E (ApoE) genotypes.


METHODS
BMI, ApoE genotype and plasma level of lipid were measured in 324 obese children. Genotype of ApoE was performed with polymerase chain reaction (PCR).


RESULTS
Distribution of genotypes was E3/3 in 198(61.1%), E3/4 in 36(11.1%), E2/3 in 54 (16.7%) and E4/4 in 36(11.1%). In the ApoE3 group, BMI correlated significantly with all indices of blood lipid (P < 0.05). However, with the exception of low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), apolipoprotein B (ApoB), correlation between other indices of blood lipid and BMI varied in the ApoE genotypes. In the ApoE2 group, BMI correlated significantly with TG (P < 0.05), but not with ApoA I or high-density lipoprotein-cholesterol (HDL-C). In the ApoE4 group, BMI correlated significant with HDL-C and ApoA I (P < 0.05), but not with TG.


CONCLUSIONS
Polymorphism of the ApoE gene could play a role in association of BMI with plasma level of lipid.
Zhang
X
X
Department of Pediatrics Renmin Hospital of Wuhan University, Hubei 430060, China.
Xia
G
G
Mai
G
G
D016632:Apolipoprotein A-I / Q000097:blood; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood* / Q000235:genetics; D008297:Male; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005819:Genetic Markers; D008055:Lipids; D014280:Triglycerides