[The effects of suicide gene therapy system on adenoid cystic carcinoma of salivary gland in athymic mice].
OBJECTIVE
To study the effects of HSV-tk/GCV system on adenoid cystic carcinoma (ACC) in vivo.


METHODS
The cell strain of ACC-M (highly metastatic to the lung) was inoculated into the flank of nude mice, then treated with HSV-tk/GCV system.


RESULTS
The system can inhibit the tumor growth greatly, moreover this function has bystander effect.


CONCLUSIONS
HSV-tk/GCV system can be to treat ACC.
Sun
C
C
Shanghai Research Centre of Life Sciences, the Chinese Academy of Sciences, Shanghai 200031, China.
He
R
R
Zhang
Z
Z
D000818:Animals; D003528:Carcinoma, Adenoid Cystic / Q000628:therapy*; D015774:Ganciclovir / Q000008:administration & dosage* / Q000627:therapeutic use; D015316:Genetic Therapy; D066298:In Vitro Techniques; D051379:Mice; D008819:Mice, Nude; D012468:Salivary Gland Neoplasms / Q000628:therapy*; D018139:Simplexvirus / Q000201:enzymology; D013937:Thymidine Kinase / Q000235:genetics
D013937:Thymidine Kinase; D015774:Ganciclovir