title: [Effect of calmodulin inhibitor on spinal cord injury].
abstract: OBJECTIVE
  To evaluate the effect of a special calmodulin (CaM) inhibitor-trifluoperizine (TFP) on spinal cord injury (SCI) and the role of CaM in SCI.
  
  
  METHODS
  We observed the effect of TFP on spinal cord blood flow (SCBF), motor evoked potentials (MEP) and motor function in SCI by using hydrogen clearance, inclined plane and electro physiological technique.
  
  
  RESULTS
  There was significant improvement of SCBF, MEP and motor function with TFP, when adrenaline maintained the system arterial pressure in SCI.
  
  
  CONCLUSIONS
  Prevention by TFP of spinal cord function in SCI suggested that CaM plays a role in the pathogenesis of SCI.
authors.affiliation: Department of Orthopedics, 304th Hospital of Chenese People's Liberation Army, Beijing 100037.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Hou
authors.forename: R
authors.initials: R
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002147:Calmodulin / Q000037:antagonists & inhibitors* / Q000502:physiology; D019054:Evoked Potentials, Motor / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D013116:Spinal Cord / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000188:drug therapy / Q000503:physiopathology*; D014268:Trifluoperazine / Q000494:pharmacology*
chemical_list: D014150:Antipsychotic Agents; D002147:Calmodulin; D014268:Trifluoperazine