Intracortical inhibition is reduced in a patient with a lesion in the posterolateral thalamus.
We describe a patient who developed a complex movement disorder following an ischemic lesion in the right posterolateral thalamus. Transcranial magnetic stimulation showed a shortening of the cortical silent period and deficient cortico-cortical inhibition using paired magnetic pulses on the affected side, indicating reduced effectiveness of intracortical inhibitory mechanisms.
Münchau
Alexander
A
Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Orth
Michael
M
Rothwell
John C
JC
Di Lazzaro
Vincenzo
V
Oliviero
Antonio
A
Profice
Paolo
P
Tonali
Pietro
P
Pramstaller
Peter P
PP
Bhatia
Kailash P
KP
D000328:Adult; D055590:Electromagnetic Phenomena / Q000379:methods*; D004576:Electromyography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009069:Movement Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D009433:Neural Inhibition / Q000502:physiology*; D020656:Posterior Thalamic Nuclei / Q000473:pathology*; D014743:Videotape Recording