Structure motif discovery and mining the PDB.
BACKGROUND
Many of the most interesting functional and evolutionary relationships among proteins are so ancient that they cannot be reliably detected through sequence analysis and are apparent only through a comparison of the tertiary structures. The conserved features can often be described as structural motifs consisting of a few single residues or Secondary Structure (SS) elements. Confidence in such motifs is greatly boosted when they are found in more than a pair of proteins.


RESULTS
We describe an algorithm for the automatic discovery of recurring patterns in protein structures. The patterns consist of individual residues having a defined order along the protein's backbone that come close together in the structure and whose spatial conformations are similar. The residues in a pattern need not be close in the protein's sequence. The work described in this paper builds on an earlier reported algorithm for motif discovery. This paper describes a significant improvement of the algorithm which makes it very efficient. The improved efficiency allows us to use it for doing unsupervised learning of patterns occurring in small subsets in a large set of structures, a non-redundant subset of the Protein Data Bank (PDB) database of all known protein structures.
Jonassen
Inge
I
Department of Informatics, University of Bergen, HIB, N5020 Bergen, Norway. Inge.Jonassen@ii.uib.no
Eidhammer
Ingvar
I
Conklin
Darrell
D
Taylor
William R
WR
D000465:Algorithms; D020816:Amino Acid Motifs; D019295:Computational Biology; D003553:Cystine / Q000737:chemistry; D030562:Databases, Protein; D015394:Molecular Structure; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D012984:Software
D011506:Proteins; D003553:Cystine