title: Coupling of folding and binding for unstructured proteins.
abstract: There are now numerous examples of proteins that are unstructured or only partially structured under physiological conditions and yet are nevertheless functional. Such proteins are especially prevalent in eukaryotes. In many cases, intrinsically disordered proteins adopt folded structures upon binding to their biological targets. Many new examples of coupled folding and binding events have been reported recently, providing new insights into mechanisms of molecular recognition.
authors.affiliation: Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. dyson@scripps.edu
authors.forename: H Jane
authors.initials: HJ
authors.lastname: Dyson
authors.forename: Peter E
authors.initials: PE
authors.lastname: Wright
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology; D005057:Eukaryotic Cells; D006801:Humans; D011485:Protein Binding / Q000502:physiology*; D017510:Protein Folding; D015398:Signal Transduction; D016335:Zinc Fingers / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins