Antioxidant properties of 8.0.4'-neolignans.
A series of naturally occurring 8.0.4'-neolignans (1a-d, 1g, 2g, 2h) and their analogues (le-f, lh, 1i, 2a-f, 2i) have been synthesized in racemic form starting from commercially available phenols, such as eugenol, isoeugenol and 4-allyl-2,6-dimethoxyphenol and from aromatic aldehydes, such as piperonal, veratraldehyde and 3,4,5-trimethoxybenzaldehyde. The inhibitory activity of these compounds on superoxide anion (O2.-) release by human polymorphonuclear leukocytes (PMNLs) was tested and the structure-activity relationship was also studied.
Kónya
K
K
Department of Organic Chemistry, University of Debrecen, Hungary.
Varga
Z S
ZS
Antus
S
S
D000447:Aldehydes / Q000737:chemistry; D000975:Antioxidants / Q000494:pharmacology*; D001547:Benzaldehydes / Q000737:chemistry; D052117:Benzodioxoles; D002478:Cells, Cultured; D005054:Eugenol / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D017705:Lignans / Q000138:chemical synthesis / Q000494:pharmacology*; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010636:Phenols / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D013481:Superoxides / Q000378:metabolism
D000447:Aldehydes; D000975:Antioxidants; D001547:Benzaldehydes; D052117:Benzodioxoles; D017705:Lignans; D010636:Phenols; D013481:Superoxides; D005054:Eugenol; C036643:isoeugenol; C112468:4-allyl-2,6-dimethoxyphenol; C005454:piperonal; C427725:veratraldehyde