[Primary splenic CD8-positive diffuse large B-cell lymphoma].
A 71-year-old woman was admitted for further examination of an increased serum LDH level. Abdominal ultrasonography and CT scan showed a large tumor in her spleen. Because malignant lymphoma was suspected, the spleen was removed for diagnosis and treatment planning. The histopathological and immunohistochemical features of the tumor indicated diffuse large B-cell lymphoma (DLBL). The flow-cytometric immunophenotype of the lymphoma cells was CD2-, CD3-, CD4-, CD5-, CD8+, CD10+, CD19+, CD20+, CD23-, kappa+, lambda-, CD25+, and CD56-. From these findings, the patient was diagnosed as having CD8+ DLBL. To our knowledge, this is the first reported case of primary splenic CD8-positive DLBL.
Toyama
T
T
Second Department of Internal Medicine, Miyazaki Medical School.
Kubuki
Y
Y
Sasaki
H
H
Hidaka
T
T
Okamoto
M
M
Suzuki
M
M
Tsubouchi
H
H
D000368:Aged; D016827:CD8 Antigens / Q000032:analysis*; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis*; D013160:Splenic Neoplasms / Q000175:diagnosis*
D016827:CD8 Antigens