Fluctuations in plasma macrophage colony-stimulating factor levels during autologous peripheral blood stem cell transplantation for haematologic diseases.
Plasma macrophage colony-stimulating factor (M-CSF) levels were measured in 13 haematologic patients treated with autologous peripheral blood stem cell transplantation (PBSCT). Six of the patients showed an increase in M-CSF peak levels (>3000 pg/ml) during the conditioning and stem cell infusion period. The peak levels of M-CSF in this phase correlated with thrombomodulin levels, indicating the endothelial origin of plasma M-CSF. However, the M-CSF levels were not influenced by TNFalpha. More patients with high M-CSF levels (>5000 pg/ml) suffered from organ failure than those with lower M-CSF levels. These results suggest that high M-CSF levels may correlate with cellular or organ damage in patients treated with PBSCT.
Saigo
K
K
Blood Transfusion Division, Kobe University Hospital, Kobe, Japan. saigo@med.kobe-u.ac.jp
Sugimoto
T
T
Matsui
T
T
Ryo
R
R
Kumagai
S
S
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001773:Blood Cells / Q000637:transplantation; D004727:Endothelium / Q000378:metabolism / Q000473:pathology; D006402:Hematologic Diseases / Q000097:blood / Q000150:complications / Q000628:therapy*; D006801:Humans; D017093:Liver Failure / Q000378:metabolism; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000150:complications / Q000628:therapy; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D008875:Middle Aged; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D018180:Thrombomodulin / Q000097:blood; D019172:Transplantation Conditioning / Q000379:methods; D014182:Transplantation, Autologous / Q000009:adverse effects; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015415:Biomarkers; D018180:Thrombomodulin; D014409:Tumor Necrosis Factor-alpha; D016173:Macrophage Colony-Stimulating Factor