title: High prevalence of anticardiolipin antibodies in patients with HCV-associated oral lichen planus.
abstract: Hepatitis C virus (HCV) has been linked to extrahepatic manifestations such as oral lichen planus (OLP). In addition, anticardiolipin antibodies (aCL) and cryoglobulin have been demonstrated in chronic hepatitis C. The aim of this study was to investigate these prevalences in patients with HCV-associated OLP. The prospective study investigated the role of these factors in 133 subjects: 28 with OLP-HCV(+) (group 1), 22 with OLP-HCV(-) (group 2), 33 without OLP-HCV(+) (group 3), and 50 healthy volunteers matched for age and sex served as control group (group 4). Levels of immunoglobulin G (IgG) and IgM aCL antibodies, and cryoglobulin in serum were evaluated by enzyme-linked immunosorbent assay. The prevalence of aCL in groups 1, 2, 3, and 4 were 32.1, 18, 36.3, and 8%, respectively. The positive rate of aCL was significantly higher in groups 1 and 3 than that in the control group (group 1; p=0.02 vs. the control group, group 3; p<0.01 vs. the control group). There were no significant differences in cryoglobulin among the groups. The findings of the present study showed a high prevalence of IgG and IgM aCL in the serum of patients with HCV infectious diseases. A positive factor for aCL was determined by age, sex, the presence of OLP, and HCV infection.
authors.affiliation: Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume 830-0011, Japan. nagao@med.kurume-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Nagao
authors.forename: K
authors.initials: K
authors.lastname: Tsubone
authors.forename: R
authors.initials: R
authors.lastname: Kimura
authors.forename: S
authors.initials: S
authors.lastname: Hanada
authors.forename: R
authors.initials: R
authors.lastname: Kumashiro
authors.forename: T
authors.initials: T
authors.lastname: Ueno
authors.forename: M
authors.initials: M
authors.lastname: Sata
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017153:Antibodies, Anticardiolipin / Q000097:blood* / Q000276:immunology; D003450:Cryoglobulins; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D017676:Lichen Planus, Oral / Q000097:blood / Q000150:complications / Q000276:immunology* / Q000821:virology; D008107:Liver Diseases / Q000150:complications / Q000276:immunology / Q000821:virology; D008297:Male; D008875:Middle Aged; D015995:Prevalence
chemical_list: D017153:Antibodies, Anticardiolipin; D003450:Cryoglobulins; D007074:Immunoglobulin G; D007075:Immunoglobulin M