[Clinicopathologic factors influencing the serum of interleukin-12 level of patients with PHC: multivariate statistical analysis].
OBJECTIVE
To investigate clinicopathologic factors influencing the serum of IL-12 level of patients with PHC.


METHODS
Serum interleukin-12 (IL-12) level was determined by ELISA in 16 patients with primary hepatic carcinoma (PHC). The following clinicopathologic factors were considered for the serum IL-12 effect: age, serum albumin and serum total bilirubin, size of tumor, number of tumor, tumor thrombus of portal vessels (present or absent), time of operation, tumor resected (yes or no), histological grade of tumor, and the amount of lost blood during operation. Dependent variables were serum IL-12 level at 1 day before operation and at 1 and 7 days after operation. The multivariate results were confirmed using multiple regression analysis.


RESULTS
Size of tumor and serum albumin greatly affected serum IL-12 level before operation. Serum total bilirubin and age affected serum IL-12 level. It was significantly different before and after operation, because of the amount of lost blood.


CONCLUSIONS
The main effective factors of serum IL-12 level were size of tumor and the hepatic function of patients. Operative trauma was the major factor reducing IL-12 level after operation.
Qiao
S
S
Department of Surgery, Tongji Hospital, Tongji Medical University, Wuhan 430030.
Chen
X
X
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000473:pathology* / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D018664:Interleukin-12 / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D013997:Time Factors
D018664:Interleukin-12