title: Resistance to Ralstonia solanacearum in Arabidopsis thaliana is conferred by the recessive RRS1-R gene, a member of a novel family of resistance genes.
abstract: The identification of two Arabidopsis thaliana genes involved in determining recessive resistance to several strains of the causal agent of bacterial wilt, Ralstonia solanacearum, is reported. Dominant (RRS1-S) and recessive (RRS1-R) alleles from susceptible and resistant accessions encode highly similar predicted proteins differing in length and which present a novel structure combining domains found in plant Toll-IL-1 receptor-nucleotide binding site-leucin-rich repeat resistance proteins and a WRKY motif characteristic of some plant transcriptional factors. Although genetically defined as a recessive allele, RRS1-R behaves as a dominant resistance gene in transgenic plants. Sequence analysis of the RRS1 genes present in two homozygous intragenic recombinant lines indicates that several domains of RRS1-R are essential for its resistance function. Additionally, RRS1-R-mediated resistance is partially salicylic acid- and NDR1-dependent, suggesting the existence of similar signaling pathways to those controlled by resistance genes in specific resistance.
authors.affiliation: Max-Planck-Institut fur Züchtungsforschung, Abteilung Biochemie, Carl-von-Linne-Weg 10, D-50829 Cologne, Germany.
authors.forename: Laurent
authors.initials: L
authors.lastname: Deslandes
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Olivier
authors.forename: Frederic
authors.initials: F
authors.lastname: Theulieres
authors.forename: Judith
authors.initials: J
authors.lastname: Hirsch
authors.forename: Dong Xin
authors.initials: DX
authors.lastname: Feng
authors.forename: Peter
authors.initials: P
authors.lastname: Bittner-Eddy
authors.forename: Jim
authors.initials: J
authors.lastname: Beynon
authors.forename: Yves
authors.initials: Y
authors.lastname: Marco
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics* / Q000378:metabolism*; D029681:Arabidopsis Proteins; D003001:Cloning, Molecular; D005808:Genes, Recessive; D016946:Gram-Negative Aerobic Rods and Cocci / Q000472:pathogenicity*; D007113:Immunity, Innate / Q000235:genetics*; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010935:Plant Diseases / Q000235:genetics*; D010940:Plant Proteins / Q000235:genetics*; D017434:Protein Structure, Tertiary; D011994:Recombinant Proteins / Q000378:metabolism; D011995:Recombination, Genetic; D020156:Salicylic Acid / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D013997:Time Factors; D014157:Transcription Factors / Q000502:physiology
chemical_list: D029681:Arabidopsis Proteins; C109369:NDR1 protein, Arabidopsis; D010940:Plant Proteins; D011994:Recombinant Proteins; D014157:Transcription Factors; D020156:Salicylic Acid