title: Synthesis of 2,2'-dihydroxybisphenols and antiviral activity of some bisphenol derivatives.
abstract: New diphenylmethane-type 2,2'-dihydroxybisphenols (5a-d) were prepared regioselectively in good yields. We evaluated the antiviral activity of some bisphenol derivatives synthesized by the plaque reduction assay. Most of the compounds showed significant antiviral activity and the 4,4'-dihydroxybisphenol derivative (10) showed higher activity than 2,2'-bisphenol derivatives. This compound had EC50 value of 1.8 microg/ml.
authors.affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan. kunihiro@cis.fukuoka-u.ac.jp
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Sumoto
authors.forename: Nobuko
authors.initials: N
authors.lastname: Mibu
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yokomizo
authors.forename: Masaru
authors.initials: M
authors.lastname: Uyeda
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D010636:Phenols