[Effect of recombinant human growth hormone with total parenteral nutrition on albumin synthesis in patients with peritoneal sepsis].
OBJECTIVE
To investigate the effect of recombinant human growth hormone (rhGH) in combination with total parenteral nutrition (TPN) on albumin synthesis in patients with peritoneal sepsis.


METHODS
17 patients with peritoneal sepsis were divided randomly into two groups. The control group received TPN only for 7 days, and the GH group received both rhGH (12 U/d) and TPN for 7 days. The TPN scheme and other treatment were the same in the two groups.


RESULTS
Serum albumin, prealbumin, and transferrin concentration were increased in patients in the GH group (P < 0.01), but no apparent effect was observed in the control group (P > 0.05).


CONCLUSIONS
In condition of serious peritoneal sepsis, TPN can not increase albumin, prealbumin, and transferrin synthesis alone, whereas rhGH in combination with TPN significantly increase the synthesis of visceral proteins.
Li
W
W
Institute of General Surgery, Nangjing General Hospital, People's Liberation Army, Nangjing 210002.
Li
J
J
Xu
B
B
Yin
L
L
Wang
L
L
Gu
J
J
Ren
J
J
Quan
Z
Z
D000293:Adolescent; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000096:biosynthesis* / Q000187:drug effects; D003131:Combined Modality Therapy; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D010532:Peritoneal Diseases / Q000378:metabolism* / Q000628:therapy; D011228:Prealbumin / Q000096:biosynthesis / Q000187:drug effects; D011994:Recombinant Proteins / Q000627:therapeutic use; D018805:Sepsis / Q000378:metabolism* / Q000628:therapy; D012709:Serum Albumin / Q000096:biosynthesis / Q000187:drug effects; D013997:Time Factors; D014168:Transferrin / Q000096:biosynthesis / Q000187:drug effects; D016896:Treatment Outcome
D001798:Blood Proteins; D011228:Prealbumin; D011994:Recombinant Proteins; D012709:Serum Albumin; D014168:Transferrin; D019382:Human Growth Hormone