In vitro synergy testing of levofloxacin, ofloxacin, and ciprofloxacin in combination with aztreonam, ceftazidime, or piperacillin against Pseudomonas aeruginosa.
The synergistic potential of levofloxacin, ofloxacin and ciprofloxacin combined with aztreonam, ceftazidime, or piperacillin was compared using 24 strains of Pseudomonas aeruginosa with varying susceptibility profiles. Levofloxacin and ciprofloxacin demonstrated similar in vitro activity, with ofloxacin demonstrating less activity compared to the other agents. Predominantly additive effects were seen with all combinations, with no significant differences detected between the fluoroquinolone agents.
Pendland
Susan L
SL
The University of Illinois at Chicago, Department of Pharmacy Practice, Microbiology Research Laboratory, Chicago, IL, USA. Pendland@uic.edu
Messick
Chad R
CR
Jung
Rose
R
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001398:Aztreonam / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology*; D004357:Drug Synergism; D006801:Humans; D007769:Lactams / Q000494:pharmacology*; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D008997:Monobactams / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D000890:Anti-Infective Agents; D002511:Cephalosporins; D007769:Lactams; D008997:Monobactams; D010406:Penicillins; D002939:Ciprofloxacin; D064704:Levofloxacin; D002442:Ceftazidime; D015242:Ofloxacin; D001398:Aztreonam; D010878:Piperacillin