The cell cycle in steroid hormone regulated proliferation and differentiation.
Steroid hormones mediate pleiotropic cellular processes involved in metabolism, cellular proliferation, and differentiation. The ability of the cell to respond to its hormonal environment is transduced by nuclear receptors (NRs) that bind both hormone and DNA. Hence, NRs represent a link between the external hormonal milieu and the genes that control cell physiology. Therefore, understanding the effects of steroid hormones on proliferation and differentiation requires a knowledge of the cell cycle, the interaction of NRs at the level of transcription, and the potential areas of cross-talk between these two.
Amanatullah
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Albert Einstein College of Medicine Comprehensive, Cancer Center Division of Hormone Responsive Tumors, Bronx, New York, USA.
Zafonte
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Pestell
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RG
D000818:Animals; D001692:Biological Transport; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology*; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D016213:Cyclins / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D005938:Glucocorticoids / Q000494:pharmacology / Q000502:physiology; D012739:Gonadal Steroid Hormones / Q000494:pharmacology / Q000502:physiology; D006728:Hormones / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D009928:Organ Specificity; D011987:Receptors, Steroid / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013256:Steroids / Q000494:pharmacology / Q000502:physiology*; D014158:Transcription, Genetic / Q000187:drug effects / Q000502:physiology; D014212:Tretinoin / Q000494:pharmacology / Q000502:physiology; D014807:Vitamin D / Q000494:pharmacology / Q000502:physiology
D016213:Cyclins; D005938:Glucocorticoids; D012739:Gonadal Steroid Hormones; D006728:Hormones; D011987:Receptors, Steroid; D013256:Steroids; D014807:Vitamin D; D014212:Tretinoin; D018844:Cyclin-Dependent Kinases