[Identification of elements responsible for regulation of keratinocyte growth factor gene by steroid hormones and 1,25-dihydroxyvitamin D3].
Data are provided on the up-regulation of keratinocyte growth factor gene (kgf) at mRNA and protein level in prostate cancer cells (LNCaP) stimulated by 1,25-dihydroxy-vitamin D3 and 17-beta-estradiol (E2). The computer analysis of the 5-flanking region of kgf gene using different software and databases (TESS, TRANSFAC etc.) enabled us to identify some potential elements responsible for binding the nuclear receptors of vitamin D3, E2, and some other steroid hormones.
Aksenov
N L
NL
Institute of Cytology RAS, St. Petersburg, Russia. NiLAksenov@mail.ru
Liakhovich
A V
AV
Mikhel'son
V M
VM
Spivak
I V
IV
Tuohimaa
P
P
Ylikomi
T
T
D020121:5' Untranslated Regions / Q000235:genetics; D002117:Calcitriol / Q000494:pharmacology*; D030561:Databases, Nucleic Acid; D004958:Estradiol / Q000494:pharmacology*; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors / Q000235:genetics*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D011401:Promoter Regions, Genetic / Q000235:genetics; D017422:Sequence Analysis, DNA; D014407:Tumor Cells, Cultured
D020121:5' Untranslated Regions; C496453:FGF7 protein, human; D051523:Fibroblast Growth Factor 7; D004958:Estradiol; D005346:Fibroblast Growth Factors; D002117:Calcitriol