Enhancement by cyclosporine A and tacrolimus of serotonin-induced formation of small platelet aggregation.
Cyclosporine A (CsA) may increase the incidence of thrombotic events, but whether tacrolimus (Tc) has such effects is still unclear. The serotonergic system has been linked to the thrombotic effects of CsA, but a direct effect of CsA on serotonin-induced platelet aggregation has not been demonstrated because of methodological difficulties. We measured the effects of CsA and Tc on serotonin-induced platelet aggregate formation by particle counting using light scattering. CsA and Tc both enhanced serotonin-induced formation of small platelet aggregates, however, neither CsA nor Tc affected aggregation induced by high or low concentrations of ADP, with or without addition of a serotonin receptor antagonist. Both CsA and Tc enhance platelet aggregation induced via the serotonin pathway.
Suehiro
A
A
Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Sawada
A
A
Hasegawa
Y
Y
Takatsuka
H
H
Higasa
S
S
Kakishita
E
E
D000244:Adenosine Diphosphate / Q000494:pharmacology; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D016572:Cyclosporine / Q000494:pharmacology*; D004357:Drug Synergism; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008027:Light; D010974:Platelet Aggregation / Q000187:drug effects*; D012542:Scattering, Radiation; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D016559:Tacrolimus / Q000494:pharmacology*; D019851:Thrombophilia / Q000139:chemically induced
D007166:Immunosuppressive Agents; D012702:Serotonin Antagonists; D012701:Serotonin; D000244:Adenosine Diphosphate; D016572:Cyclosporine; D016559:Tacrolimus