[Experimental studies on the effect of the immunosuppressant FK-506 on penetrating keratoplasty rejection model in rats].
OBJECTIVE
To study the immunosuppressive effects of FK-506 on allogeneic transplantation in a rat model.


METHODS
Inbred strain Lou rats were used as recipients, and F344 rats were used as donors. Subconjunctival injection of FK-506 0.1 mg/kg and cyclosporine A (CsA) 3 mg/kg were administered respectively for 2 weeks, and the grafts were inspected by clinical evaluation.


RESULTS
The group receiving FK-506 had a significant delay in allograft rejection with mean survival time (22.1 +/- 5.17) days vs. (18.4 +/- 1.4) days for the CsA group and (12.1 +/- 2.13) days for the control group (P < 0.01).


CONCLUSIONS
It is indicated that FK-506 would be a useful drug to suppress corneal graft rejection.
Lü
L
L
Department of Ophthalmology, Affiliated Tong Ren Hospital, Capital Medical University, Beijing 100730.
Zhang
W
W
Sun
X
X
D000818:Animals; D003315:Cornea / Q000187:drug effects / Q000276:immunology; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D015948:Keratoplasty, Penetrating; D051381:Rats; D011916:Rats, Inbred F344; D016559:Tacrolimus / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D016559:Tacrolimus