title: Evaluation of the efficacy of the crude extract of Aloe secundiflora in chickens experimentally infected with Newcastle disease virus.
abstract: Two replicate experiments were carried out to verify the efficacy of Aloe species (Aloaceae) as used for the control of Newcastle disease (ND) in rural poultry in free-range systems among several communities in Tanzania. Four months old local chickens free of Newcastle disease antibodies were used. Following inoculation with ND virus, body weights, clinical signs, antibody levels and mortality were monitored. Results showed that there was reduced mortality rate and the severity of clinical signs during the acute phase of the infection in Aloe treated chickens compared with the non-treated ones. However, there was no significant effect of the Aloe on the antibody levels that were attributed to the recovery of the surviving chickens. The findings of this study suggest that Aloe secundiflora could be a potential candidate on the management of Newcastle disease in chickens. Further studies are in progress to identify the active ingredients of A. secundiflora against Newcastle disease virus.
authors.affiliation: Department of Zoology and Marine Biology, University of Dar es Salaam, PO Box 35064, Dar es Salaam, Tanzania.
authors.forename: R K
authors.initials: RK
authors.lastname: Waihenya
authors.forename: M M A
authors.initials: MM
authors.lastname: Mtambo
authors.forename: G
authors.initials: G
authors.lastname: Nkwengulila
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000818:Animals; D002645:Chickens; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data; D009521:Newcastle Disease / Q000188:drug therapy* / Q000401:mortality / Q000821:virology; D009522:Newcastle disease virus; D008517:Phytotherapy / Q000379:methods* / Q000706:statistics & numerical data; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D010936:Plant Extracts