[The influence of chosen hormones on lipids and its correlation during normal pregnancy].
OBJECTIVE
Lipids and hormones levels in nonpregnant and pregnant with uneventful gestation (from I, II, III trimester) were estimated and its correlation was evaluated.


METHODS
The study group consisted of 219 women: 49 nonpregnant and 170 pregnant women (35 in I trimester, 35 in II and 100 in III trimester of gestation). All subjects were healthy. Following parameters were measured in blood serum: total lipids, LDL total fraction, (beta-lipoproteids), cholesterol both total and free, HDL cholesterol, LDL cholesterol. Percentage of free cholesterol contained on total cholesterol was evaluated. HPL and estrogens levels were estimated.


RESULTS
Serum levels of total lipids, phosphlipids, triglicerides, total fraction of LDL and its contains of cholesterol increase with gestational age (p < 0.001). During pregnancy positive correlation between estrogens, HPL and triglycerides was also observed (p < 0.001). Additionally in II trimester positive correlation of total cholesterol, phospholipids and HPL was noted (respectively r = 0.469 p < 0.001 and r = 0.452 p < 0.01).


CONCLUSIONS
In case of women with uneventful pregnancy positive correlation between estrogens and total lipids, total fractions LDL and triglycerides was stated. Also positive correlation among lipids parameters and HPL concentration was noted. No correlation between HPL and free cholesterol, LDL, HDL cholesterol nor between estrogens and total cholesterol, free cholesterol and LDL cholesterol was found. Lipids status in case of nonpregnant women is multihormonaly influenced.
Smolarczyk
R
R
II Katedra i Klinika Połoznictwa i Ginekologii Akademii Medycznej w Warszawie.
Czajkowski
K
K
Wójcicka-Jagodzińska
J
J
Kostro
I
I
Demkow
K
K
Teliga-Czajkowska
J
J
Mrozek
J
J
D000367:Age Factors; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D004967:Estrogens / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D008055:Lipids / Q000097:blood*; D010743:Phospholipids / Q000097:blood; D010928:Placental Lactogen / Q000097:blood; D011247:Pregnancy / Q000097:blood*; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004967:Estrogens; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D010928:Placental Lactogen