title: Increased frequency dependence of specific airway resistance in patients with laryngeal hemiplegia.
abstract: The aim of this study was to investigate whether patients with laryngeal hemiplegia (LH) show a frequency-dependent increase in specific airway resistance (sRaw), measured by body plethysmography. In addition to the flow-volume loop, usually considered in the functional evaluation of upper airway obstructions, variations in sRaw at respiratory frequencies of 30+/-5 (=0.5 Hz), 60+/-5 (=1 Hz) and 90+5 breaths x min(-1) (=1.5 Hz) in 21 never-smoking patients (LH group, mean age+/-SD 55+/-12.09 yrs; 17 females) whose unilateral vocal-cord paralysis was documented by laryngoscopy and who had no signs or symptoms of other respiratory diseases studied. They were compared to 21 healthy control subjects (C group: 50.1+/-15.44 yrs; 10 females). The sRaw values at 30+/-5 breaths min(-1) were similar in the two groups (5.54+/-1.88 versus 5.68+/-1.06 cmH2O x s(-1); p=NS), but at increasing frequencies (30+/-5, 60+/-5 and 90+/-5 breaths min(-1)), they progressively and significantly increased in the LH patients (from 5.54+/-1.88 to 6.63+/-1.96 and 8.05+/-2.6 mH2O x s(-1); p<0.0005), and not significantly in controls (5.68+/-1.06, 5.85+/-0.95 and 5.9+/-1.12 cmH2O x s(-1); p=NS). Linear discriminant analysis using AsRaw (sRaw at 1.5 Hz-sRaw at 0.5 Hz) and forced inspiratory flow at 50% of the vital capacity made it possible to correctly classify all of the controls and 19 of the 21 patients. In conclusion, the multiple, rapid and noninvasive plethysmographical testing of frequency-dependent increase in specific airway resistance with the flow-volume loop, allows the sufficiently satisfactory discrimination of laryngeal hemiplegia patients from controls.
authors.affiliation: Institute of Respiratory Diseases, University of Milan, Ospedale Maggiore of Milan, IRCCS, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Fasano
authors.forename: L
authors.initials: L
authors.lastname: Raiteri
authors.forename: E
authors.initials: E
authors.lastname: Bucchioni
authors.forename: S
authors.initials: S
authors.lastname: Guerra
authors.forename: G
authors.initials: G
authors.lastname: Cantarella
authors.forename: M G
authors.initials: MG
authors.lastname: Massari
authors.forename: B M
authors.initials: BM
authors.lastname: Cesana
authors.forename: L
authors.initials: L
authors.lastname: Allegra
mesh_terms: D000328:Adult; D000368:Aged; D000403:Airway Resistance; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D001239:Inhalation; D008297:Male; D008875:Middle Aged; D010993:Plethysmography, Whole Body; D012123:Pulmonary Ventilation; D014826:Vocal Cord Paralysis / Q000175:diagnosis* / Q000503:physiopathology*