Lectin (WGA)-dependent superoxide anion release by neutrophils as a prognostic factor in lung cancer.
This study was performed to explore whether lectin-induced generation of superoxide anions by neutrophils, lectin-induced degranulation of these cells and NO-synthase activity in pleural effusions can be used as prognostic factors of primary lung cancer patients. Among the activities tested, increased generation of superoxide by Triticum vulgaris agglutinin (WGA)-activated neutrophils showed prognostic relevance. Thus, this lectin-dependent reactivity of immune cells warrants further investigation in addition to the histochemical analysis.
Timoshenko
A V
AV
Institute of Photobiology, National Academy of Sciences of Belarus, Minsk. atimoshe@uwo.ca
Andre
S
S
Kayser
K
K
Gabius
H J
HJ
D015550:Cell Degranulation / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000378:metabolism*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D016066:Pleural Effusion, Malignant / Q000201:enzymology; D011379:Prognosis; D016897:Respiratory Burst / Q000187:drug effects; D013481:Superoxides / Q000378:metabolism*; D014909:Wheat Germ Agglutinins / Q000494:pharmacology*
D014909:Wheat Germ Agglutinins; D013481:Superoxides; D019001:Nitric Oxide Synthase