Direct effect of Pa(CO2) on respiratory sinus arrhythmia in conscious humans.
Respiratory sinus arrhythmia (RSA) may improve the efficiency of pulmonary gas exchange by matching the pulmonary blood flow to lung volume during each respiratory cycle. If so, an increased demand for pulmonary gas exchange may enhance RSA magnitude. We therefore tested the hypothesis that CO2 directly affects RSA in conscious humans even when changes in tidal volume (V(T)) and breathing frequency (F(B)), which indirectly affect RSA, are prevented. In seven healthy subjects, we adjusted end-tidal PCO2 (PET(CO2)) to 30, 40, or 50 mmHg in random order at constant V(T) and F(B). The mean amplitude of the high-frequency component of R-R interval variation was used as a quantitative assessment of RSA magnitude. RSA magnitude increased progressively with PET(CO2) (P < 0.001). Mean R-R interval did not differ at PET(CO2) of 40 and 50 mmHg but was less at 30 mmHg (P < 0.05). Because V(T) and F(B) were constant, these results support our hypothesis that increased CO2 directly increases RSA magnitude, probably via a direct effect on medullary mechanisms generating RSA.
Sasano
Nobuko
N
Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada M5G 2C4.
Vesely
Alex E
AE
Hayano
Junichiro
J
Sasano
Hiroshi
H
Somogyi
Ron
R
Preiss
David
D
Miyasaka
Kiyoyuki
K
Katsuya
Hirotada
H
Iscoe
Steve
S
Fisher
Joseph A
JA
D000328:Adult; D001146:Arrhythmia, Sinus / Q000097:blood* / Q000503:physiopathology; D002245:Carbon Dioxide / Q000097:blood*; D003243:Consciousness; D004562:Electrocardiography; D006801:Humans; D008297:Male; D010313:Partial Pressure; D011652:Pulmonary Circulation; D012016:Reference Values; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics; D013990:Tidal Volume
D002245:Carbon Dioxide