The radiation-induced lesions which trigger the bystander effect.
The ionizing radiation induced bystander effect is initiated by damage to a cellular molecule which then gives rise to a signal exported to other cells. The nature of this damage is considered with the understanding that it may not be the same as that responsible for the traditional cellular effects of radiation. Consideration is give to amounts of endogenous damage and to radiation yields of the various candidate lesions.
Ward
John F
JF
Department of Radiology, 0610, University of California, La Jolla, San Diego, CA 92093, USA. ifward@ucsd.edu
D024201:Bystander Effect / Q000502:physiology*; D002470:Cell Survival; D002477:Cells / Q000473:pathology / Q000528:radiation effects*; D004247:DNA / Q000378:metabolism; D004249:DNA Damage / Q000235:genetics*; D004277:DNA, Single-Stranded / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D010084:Oxidation-Reduction
D004277:DNA, Single-Stranded; D004247:DNA