Biocatalytic synthesis of hydroxylated natural products using aldolases and related enzymes.
Synthetic building blocks bearing hydroxylated chiral centers are important targets for biocatalysis. Many C-C bond forming enzymes have recently been investigated for new applications and new strategies towards the synthesis of natural products and related oxygenated compounds. Several old catalysts have been studied to increase our functional knowledge of natural aldolase-type enzymes, and new mutated catalysts or catalytic antibodies have been tested for their synthetic utility.
Fessner
W D
WD
Department of Organic Chemistry, Darmstadt University of Technology, Petersenstrasse 22, D-64287 Darmstadt, Germany.
Helaine
V
V
D000446:Aldehyde-Lyases / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry; D001709:Biotechnology / Q000379:methods*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006900:Hydroxylation; D008956:Models, Chemical; D014174:Transketolase / Q000737:chemistry
D000596:Amino Acids; D002244:Carbon; D014174:Transketolase; D000446:Aldehyde-Lyases; C021541:mandelonitrile lyase