Saponins-mediated potentiation of cisplatin accumulation and cytotoxicity in human colon cancer cells.
The triterpene saponins jenisseensosides A, B, C, D were found to increase the accumulation and cytotoxicity of the anticancer agent cisplatin in human colon tumor cells. These compounds are glycosides of quillaic acid whose fucose residue was acylated by a trans- or cis-p methoxycinnamic acid. In contrast, other saponins derivatives without this acyl moiety were not found to potentiate the accumulation and cytotoxicity of cisplatin. These results suggested the importance of the acyl moiety for activity.
Gaidi
Ghezala
G
Laboratoire de Pharmacognosie, Unité MIB, JE 2244, Faculté de Pharmacie, Université de Bourgogne, Dijon Cedex, France.
Correia
Maria
M
Chauffert
Bruno
B
Beltramo
Jean-Luc
JL
Wagner
Hildebert
H
Lacaille-Dubois
Marie-Aleth
MA
D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D019073:HT29 Cells / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010984:Platinum / Q000378:metabolism*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029751:Silene; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C452944:jenisseensoside A; C452945:jenisseensoside B; C107206:jenisseensoside C; C107207:jenisseensoside D; D010984:Platinum; D009828:Oleanolic Acid; D002945:Cisplatin