title: Mapping of Myxococcus xanthus social motility dsp mutations to the dif genes.
abstract: Myxococcus xanthus dsp and dif mutants have similar phenotypes in that they are deficient in social motility and fruiting body development. We compared the two loci by genetic mapping, complementation with a cosmid clone, DNA sequencing, and gene disruption and found that 16 of the 18 dsp alleles map to the dif genes. Another dsp allele contains a mutation in the sglK gene. About 36.6 kb around the dsp-dif locus was sequenced and annotated, and 50% of the genes are novel.
authors.affiliation: Molecular Biology Institute and School of Dentistry, University of California-Los Angeles, Los Angeles, CA 90095-1668, USA.
authors.forename: Hope
authors.initials: H
authors.lastname: Lancero
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Brofft
authors.forename: John
authors.initials: J
authors.lastname: Downard
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Birren
authors.forename: Chad
authors.initials: C
authors.lastname: Nusbaum
authors.forename: Jerome
authors.initials: J
authors.lastname: Naylor
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Shi
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Shimkets
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial / Q000235:genetics; D017353:Gene Deletion; D005798:Genes, Bacterial; D005816:Genetic Complementation Test; D008969:Molecular Sequence Data; D009068:Movement; D016941:Myxococcus xanthus / Q000235:genetics / Q000502:physiology*; D017422:Sequence Analysis, DNA
chemical_list: D001426:Bacterial Proteins