Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones.
Nicolaou
K C
KC
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 USA. kcn@scripps.edu
Namoto
K
K
Li
J
J
Ritzén
A
A
Ulven
T
T
Shoji
M
M
Zaharevitz
D
D
Gussio
R
R
Sackett
D L
DL
Ward
R D
RD
Hensler
A
A
Fojo
T
T
Giannakakou
P
P
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D034261:Epothilones; D006801:Humans; D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology*; D008854:Microscopy, Electron; D008958:Models, Molecular; D013237:Stereoisomerism; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014404:Tubulin / Q000378:metabolism / Q000648:ultrastructure; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; C113666:C12,13-cyclopropylepothilone A; C452199:C12,C13-cyclobutylepothilone A; D034261:Epothilones; D007202:Indicators and Reagents; D007783:Lactones; D013844:Thiazoles; D014404:Tubulin