title: Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase.
authors.affiliation: Institut für Organische Chemie, Universität Karlsruhe, Richard-Willstätter-Allee 2, 76128 Karlsruhe, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Arenz
authors.forename: M
authors.initials: M
authors.lastname: Thutewohl
authors.forename: O
authors.initials: O
authors.lastname: Block
authors.forename: H
authors.initials: H
authors.lastname: Waldmann
authors.forename: H J
authors.initials: HJ
authors.lastname: Altenbach
authors.forename: A
authors.initials: A
authors.lastname: Giannis
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000378:metabolism; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007700:Kinetics; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D011090:Polyenes / Q000138:chemical synthesis / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides; D051381:Rats; D015398:Signal Transduction; D013108:Sphingomyelin Phosphodiesterase / Q000037:antagonists & inhibitors* / Q000302:isolation & purification
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004791:Enzyme Inhibitors; D011090:Polyenes; D053284:Polyunsaturated Alkamides; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase; D013108:Sphingomyelin Phosphodiesterase; C054474:manumycin