[Localization of corticoliberin receptors in the rat brain].
Using the in situ hybridization, a distribution of corticotropin-releasing hormone (CRH) receptors CRH-1 and CRH-2 in the rat brain has been studied. Brain levels of CRH-1 mRNA were higher than the those of CRH-2 mRNA. Most intensive CRH-1 gene expression was observed in the forebrain, including neocortex, archicortex, paleocortex and cerebellar cortex. In addition, significant CRH-1 mRNA expression was detected in the red nucleus, pontine nucleus, cochlear nucleus and reticular tegmental nucleus. CRH-2 mRNA was intensively expressed in the olfactory structures, corticomedial amygdala, CA1-CA4 of hippocampus, ventramedial hypothalamus and several modullar nuclei. Moderate CRH-2 mRNA level were seen in the dorsomedial neostriatum. The findings indicate that within the brain two types of CRH receptors are widely expressed. A distinct pattern of CRH-1 and CRH-2 expression in the brain appears to underline the functional specifics of the CRH actions in brain structures.
Rybnikova
E A
EA
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., St. Petersburg, 199034, Nab. Makarova, 6.
Pelto-Huikko
M
M
Rakitskaia
V V
VV
Shaliapina
V G
VG
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics / Q000378:metabolism*; D000099052:CRF Receptor, Type 1
C101531:CRF receptor type 2; D012333:RNA, Messenger; D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1