Study on of bioadhesive property of carbomer 934 by a gamma camera in vivo.
OBJECTIVE
To study the bioadhesive property of carbomer934 in dog alimentary tract.


METHODS
Carbomer934 and ethylcellulose were radiolabelled with technetium-99m; and Gastrointestinal emptying rate of materials was measured using the technique of gamma scintigraphy.


RESULTS
After oral administration,the maximum intestinal radioactivity of non-bioadhesive granules and bioadhesive granules were observed in the second hour and the sixth hour respectively. Constants of stomach emptying rate of nonadhesive granules,bioadhesive granules I and bioadhesive granules II were 0.774 h(-1), 0.265 h(-1) and 0.321 h(-1) respectively on the base of gastric residual amount. Compared to nonadhesive material (ethylcellulose), the migration rate of adhesive material(carbomer934) was remarkably slower in dog alimentary canal.


CONCLUSIONS
It is concluded that, in the dog, interactions between gastrointestinal mucus layer and adhesive material or nonadhesive material were significantly different. Carbomer934 had stronger in vivo bioadhesive property than ethylcellulose.
Fu
Jie
J
West China School of Pharmacy, Sichuan University.Chengdu, 610041, China.
Sun
Xun
X
Zhang
Zhi-Rong
ZR
D000180:Acrylic Resins / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D002482:Cellulose / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D004285:Dogs; D015902:Gamma Cameras; D005746:Gastric Emptying; D005753:Gastric Mucosa / Q000000981:diagnostic imaging / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging
D000180:Acrylic Resins; D000970:Antineoplastic Agents; C006903:carbopol 940; C013517:ethyl cellulose; D002482:Cellulose