Cytotoxic and antibacterial activity of 2-oxopurine derivatives.
Initial screening of the cytotoxic and antibacterial properties of 6-substituted 2-oxopurines and dihydro-2-oxopurines revealed that several compounds exhibited cytotoxicity against K-562 cells in the same range as the well known antileukemic drug 6-mercaptopurine. Most compounds were also tested for inhibitory effect on a Gram-positive bacterium, Lactobacillus casei, as well as the mycobacterium Mycobacterium tuberculosis. Generally the 2-oxopurines exhibited low antibacterial effect.
Andresen
Geir
G
Department of Chemistry, University of Oslo, PO Box 1033, Blindern, 0315 Oslo, Norway.
Gundersen
Lise-Lotte
LL
Nissen-Meyer
Jon
J
Rise
Frode
F
Spilsberg
Bjørn
B
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D020014:K562 Cells / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011687:Purines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
C475780:2-oxopurine; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D011687:Purines