SW-163A and B, novel immunosuppressants produced by Streptomyces sp.
SW-163A and B, novel immunosuppressants, were isolated from the culture broth of Streptomyces sp. SNA15896. The molecular formulas of SW-163A and B were determined as C34H42N2O12 and C33H40N2O12 based on the HRFAB-MS analysis, respectively. Both compounds were elucidated to be a large ring ester structure through spectroscopic analyses including various NMR measurements. SW-163A and B showed immunosuppressive and antimicrobial activities in vitro.
Takahashi
K
K
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan. adagio@mxz.mesh.ne.jp
Tsuda
E
E
Kurosawa
K
K
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D005285:Fermentation; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020014:K562 Cells; D007624:KB Cells; D007959:Lymphocyte Culture Test, Mixed; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism*
D000596:Amino Acids; D007166:Immunosuppressive Agents; D010456:Peptides, Cyclic; C447401:SW-163A; C447402:SW-163B