title: A real-time classification system of thalassemic pathologies based on artificial neural networks.
abstract: Thalassemias are pathologies that derive from genetic defects of the globin genes. The most common defects among the population affect the genes that are involved in the synthesis of alpha and beta chains. The main aspects of these pathologies are well explained from a biochemical and genetic point of view. The diagnosis is fundamentally based on hematologic and genetic tests. A genetic analysis is particularly important to determine the carriers of alpha-thalassemia, whose identification by means of the hematologic parameters is more difficult in comparison with heterozygotes for alpha-thalassemia. This work investigates the use of artificial neural networks (ANNs) for the classification of thalassemic pathologies using the hematologic parameters resulting from hemochromocytometric analysis only. Different combinations of ANNs are reported, which allow thalassemia carriers to be discriminated from normals with 94% classification accuracy, 92% sensitivity, and 95% specificity. On the basis of these results, an automated system that allows real-time support for diagnoses is proposed. The automated system interfaces a hemochromo analyzer to a simple PC.
authors.affiliation: Dipartimento di Matematica e Fisica, Università di Sassari, Italy.
authors.forename: S R
authors.initials: SR
authors.lastname: Amendolia
authors.forename: A
authors.initials: A
authors.lastname: Brunetti
authors.forename: P
authors.initials: P
authors.lastname: Carta
authors.forename: G
authors.initials: G
authors.lastname: Cossu
authors.forename: M L
authors.initials: ML
authors.lastname: Ganadu
authors.forename: B
authors.initials: B
authors.lastname: Golosio
authors.forename: G M
authors.initials: GM
authors.lastname: Mura
authors.forename: M G
authors.initials: MG
authors.lastname: Pirastru
mesh_terms: D000293:Adolescent; D003661:Decision Support Techniques; D004906:Erythrocyte Count; D004909:Erythrocyte Indices; D005103:Expert Systems; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D016571:Neural Networks, Computer; D012680:Sensitivity and Specificity; D017085:alpha-Thalassemia / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D017086:beta-Thalassemia / Q000097:blood / Q000175:diagnosis* / Q000473:pathology
chemical_list: D006454:Hemoglobins