title: Leishmanicidal activity of some aliphatic diamines and amino-alcohols.
abstract: A number of aliphatic diamines and amino-alcohols and several of their alkyl, acyl and carbamoyl derivatives, have been synthesised and evaluated in vitro on cultures of Leishmania spp. In general, diamine derivatives resulted to be more potent than their amino-alcohol or amino-ether analogues. Two diamine derivatives (8b and 9d) and one amino-alcohol (6a) showed a fair inhibition of parasite growth, at concentrations below 10 microg/mL, with potencies close to that of the reference drug, amphotericin B. Some SAR considerations have been deduced.
authors.affiliation: Departamento de Quijmica Farmaceutica, Facultad de Farmacia, Univ. de Salamanca, 37007, Salamanca, Spain. olmo@usal.es
authors.forename: Esther
authors.initials: E
authors.lastname: del Olmo
authors.forename: Mario
authors.initials: M
authors.lastname: Alves
authors.forename: José L
authors.initials: JL
authors.lastname: López
authors.forename: Alba
authors.initials: A
authors.lastname: Inchaustti
authors.forename: Gloria
authors.initials: G
authors.lastname: Yaluff
authors.forename: Antonieta
authors.initials: A
authors.lastname: Rojas de Arias
authors.forename: Arturo
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007891:Leishmania / Q000187:drug effects* / Q000254:growth & development; D021261:Parasitic Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000605:Amino Alcohols; D000981:Antiprotozoal Agents; D003959:Diamines