Photoresponsive dendritic azobenzene peptides.
Two dendritic peptides containing a branched lysine core and up to eight azobenzene moieties in the periphery were synthesized on solid support employing the omega-amino acid 4-(aminomethyl)phenylazobenzoic acid. With an additional peptidic tail consisting of an oligolysine portion, water solubility was achieved for the dendrimers, which allowed for the characterization of the cis/trans photoisomerization of the dendritic azobenzene species in both organic and aqueous media. Despite the interactions between the chromophores, which occur particularly in aqueous media, at higher dilution the photoisomerization process was found to proceed to extents that should permit photomodulation of molecular recognition processes between ligands grafted to the photosensitive azobenzene units and receptor molecules.
Cattani-Scholz
A
A
Max-Planck-Institut für Biochemie, Am Klopferspitz 18a, 82152 Martinsried, Germany.
Renner
C
C
Oesterhelt
D
D
Moroder
L
L
D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D003198:Computer Simulation; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010777:Photochemistry; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D001391:Azo Compounds; D010455:Peptides; C009850:azobenzene