title: [Clinical study on sodium hyaluronate intra-articular injection in treatment of degenerative osteoarthritis of knee].
abstract: OBJECTIVE
  To evaluate the clinical effect of sodium hyaluronate (SH) intra-articular injection in treatment of degenerative osteoarthritis (DOA) of knees.
  
  
  METHODS
  One hundred patients (116 knees) suffered from DOA were treated by SH injection intra-articularly once a week for three times. According to Lysholm scoring, clinical signs such as pain, swelling, excludes, range of movement (ROM), and the ability of walking, going upstairs and downstairs, squatting, running, were assessed before and after treatment.
  
  
  RESULTS
  Ninety-six cases were followed up for 1 to 6 months. There were obvious improvements in the signs and function of knee in 39 patients (40.6%), only some improvements in 48 patients (50.0%), and no obvious improvements in other 9 patients (9.4%). The total effectiveness rate was 74.0%. No toxic or side effect was observed.
  
  
  CONCLUSIONS
  Intraarticular injection of SH has a positive effect in relief of clinical symptoms and in improvement of articular function of DOA of knee.
authors.affiliation: Department of Orthopedic Surgery, Second Xiangya Hospital, Zhongnan University, Changsha Hunan, P. R. China 410011.
authors.forename: You
authors.initials: Y
authors.lastname: Chen
authors.forename: Dan
authors.initials: D
authors.lastname: Peng
authors.forename: Cai-jiang
authors.initials: CJ
authors.lastname: Sun
authors.forename: Wan-chun
authors.initials: WC
authors.lastname: Wang
authors.forename: Ju-yuan
authors.initials: JY
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000188:drug therapy*
chemical_list: D006820:Hyaluronic Acid