title: Thrombopoietin: the novel hepatic hormone.
abstract: The glycoprotein thrombopoietin (TPO) is the major stimulator of megakaryopoiesis and platelet production. Hepatocytes express TPO mRNA at a constant rate. The plasma TPO level is inversely correlated to the mass of megakaryocytes and platelets, which degrade the hormone following its binding to specific membrane receptors.
authors.affiliation: Institute of Physiology, Medical University of Luebeck, D-23538 Luebeck, Germany.
authors.forename: Eva-Maria
authors.initials: EM
authors.lastname: Wolber
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Jelkmann
mesh_terms: D000209:Acute-Phase Proteins / Q000502:physiology; D006801:Humans; D008099:Liver / Q000502:physiology*; D008967:Molecular Biology; D013926:Thrombopoietin / Q000096:biosynthesis / Q000097:blood / Q000235:genetics / Q000502:physiology*
chemical_list: D000209:Acute-Phase Proteins; D013926:Thrombopoietin