[The expressions of Fas and Fas-L in human breast invasive ductal carcinomas and their surrounding tissues].
OBJECTIVE
To study the relationship of the expression of Fas and Fas-L with the pathogenesis and differentiation of breast invasive ductal carcinomas.


METHODS
Both carcinoma tissues and their surrounding tissues from 50 patients with breast invasive ductal carcinomas were studied for the expression of Fas and Fas-L by immunohistochemical staining.


RESULTS
The expression level of Fas in breast ductal carcinoma was significantly lower than that of tissues surrounding carcinomas, and the expression level of Fas-L in breast ductal carcinoma was significantly higher than that of tissues surrounding carcinomas. There was no significant difference in the expression of Fas and Fas-L in carcinomas with different differentiation grades.


CONCLUSIONS
The expression of Fas is downregulated and the expression of Fas-L is upregulated in human breast invasive ductal carcinomas. Human breast invasive ductal carcinomas may enhance their development through downregulating the expression of Fas and upregulating the expression of Fas-L. The expression level of Fas and Fas-L has nothing to do with the differentiation of human breast invasive ductal carcinomas.
Xia
C
C
Department of Pathology, Chaoyang Hospital, Capital Medical University, Beijing 100020.
Zhao
H
H
Tang
X
X
D001943:Breast Neoplasms / Q000378:metabolism*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism*; D053222:Fas Ligand Protein; D005260:Female; D006801:Humans; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D019014:fas Receptor / Q000096:biosynthesis*
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor