title: [The proper opportunity of surgery for rectal cancer after preoperative adjuvant chemotherapy].
abstract: OBJECTIVE
  To discuss the proper opportunity of surgery for rectal cancer after preoperative intra-arterial chemotherapy.
  
  
  METHODS
  Preoperative chemotherapy was performed on 27 rectal cancer cases at Dukes stage B and C. The therapy comprised of arterial infusion of 5-fluorouracil 600 mg/m(2), mitomycin 15 mg/m(2) and epirubicin 30 mg/m(2) for one course. Miles' or Dixon's operation was carried out 7 to 10 days later. The effects of chemotherapy were evaluated. Dynamic changes of proliferating cell nuclear antigen (PCNA) expression were studied by immunohistochemistry on paraffin-embedded sections.
  
  
  RESULTS
  Hematochezia was remitted in 19 cases. Histologically, the effects of chemotherapy were considered as slight, moderate and marked in 9, 15 and 3 cases, respectively. Side effects were slight and recovered in 4 days. There was a high expression of PCNA in rectal cancer. On the 7th to the 10th day, proliferating index was significantly higher than that of before chemotherapy (46.48 +/- 10.62)%, P < 0.05.
  
  
  CONCLUSIONS
  Preoperative adjuvant chemotherapy plays a role in the treatment of resectable rectal cancer. It is suggested that radical surgery should be carried out 5 to 6 days after intra-arterial chemotherapy.
authors.affiliation: Institute of General Surgery, Nanjing General Hospital of People's Liberation Army, Nanjing 210002.
authors.forename: Z
authors.initials: Z
authors.lastname: Xu
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: F
authors.initials: F
authors.lastname: Liu
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Qi
authors.forename: G
authors.initials: G
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Ye
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D013997:Time Factors
chemical_list: D016685:Mitomycin; D005472:Fluorouracil