Genomewide scan of hoarding in sib pairs in which both sibs have Gilles de la Tourette syndrome.
A genome scan of the hoarding phenotype (a component of obsessive-compulsive disorder) was conducted on 77 sib pairs collected by the Tourette Syndrome Association International Consortium for Genetics (TSAICG). All sib pairs were concordant for a diagnosis of Gilles de la Tourette syndrome (GTS). However, the analyses reported here were conducted for hoarding as both a dichotomous trait and a quantitative trait. Not all sib pairs in the sample were concordant for hoarding. Standard linkage analyses were performed using GENEHUNTER and Haseman-Elston methods. In addition, novel analyses with a recursive-partitioning technique were employed. Significant allele sharing was observed for both the dichotomous and the quantitative hoarding phenotypes for markers at 4q34-35 (P=.0007), by use of GENEHUNTER, and at 5q35.2-35.3 (P=.000002) and 17q25 (P=.00002), by use of the revisited Haseman-Elston method. The 4q site is in proximity to D4S1625, which was identified by the TSAICG as a region linked to the GTS phenotype. The recursive-partitioning technique examined multiple markers simultaneously. Results suggest joint effects of specific loci on 5q and 4q, with an overall P value of.000003. Although P values were not adjusted for multiple comparison, nearly all were much smaller than the customary significance level of.0001 for genomewide scans.
Zhang
Heping
H
Department of Epidemiology and Public Health, Yale Child Study Center, Yale University School of Medicine, 60 College Street, New Haven, CT 06520-8034, USA. heping.zhang@yale.edu
Leckman
James F
JF
Pauls
David L
DL
Tsai
Chin-Pei
CP
Kidd
Kenneth K
KK
Campos
M Rosario
MR
D000483:Alleles; D001526:Behavioral Symptoms / Q000150:complications / Q000235:genetics; D002877:Chromosomes, Human / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D016555:Matched-Pair Analysis; D009679:Nuclear Family; D009771:Obsessive-Compulsive Disorder / Q000150:complications* / Q000235:genetics*; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D012984:Software; D018709:Statistics, Nonparametric; D005879:Tourette Syndrome / Q000150:complications* / Q000235:genetics*
D005819:Genetic Markers