In search of a 9q13 latent centromere in 9qh polymorphic inversions.
In search of a 9q13 latent centromere in 9qh polymorphic inversions: The presence of alphoid sequences in 9q13 has prompted the suggestion that such a region could harbor a latent centromere which under certain circumstances may appear as a neocentromere. We tested this hypothesis by means of FISH with a centromere 9-specific alphoid probe in lymphocyte metaphases from 13 unrelated individuals with a 9qh polymorphic inversion. Since all inverted chromosomes had the alphoid signal onto the primary constriction, it was not possible to identify any neocentromere . We believe, however, that the number of cases was not enough to conclude that all the polymorphic inversions of chromosome 9 are genuine.
Gutiérrez-Angulo
M
M
Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jal.
Vásquez
A I
AI
Ramos
A L
AL
Domínguez
M G
MG
González-García
J R
JR
Rivera
H
H
D001483:Base Sequence; D002503:Centromere; D007446:Chromosome Inversion; D002899:Chromosomes, Human, Pair 9; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011110:Polymorphism, Genetic
D005819:Genetic Markers