title: [Orthokeratology induced infective corneal ulcer].
abstract: OBJECTIVE
  To investigate the clinical course, treatment and outcome of infective corneal ulcer induced by orthokeratology.
  
  
  METHODS
  Sixteen cases of infective corneal ulcer caused by orthokeratology were reported, including 7 cases of pseudomonas corneal ulcers, 8 cases of acanthamoeba keratitis and 1 case of mycotic keratitis. Smears and cultures from corneal scrapings for bacteria, fungi and amoeba were performed for all of the patients. According to the results of pathogenic microorganisms, different therapeutic approaches were given. Lamellar keratoplasty or penetrating keratoplasty was performed for 9 patients whose corneal lesions were serious and unresponsive to medical therapy.
  
  
  RESULTS
  After medical treatment or keratoplasty, corneal infections of all the patients were controlled. The visual acuity of most cases was improved.
  
  
  CONCLUSIONS
  The infective corneal ulcer is the most serious complication of orthokeratology. The treatment of infective corneal ulcer should be directed toward the elimination of the pathogenic microorganisms from the cornea. Keratoplasty continues to have a central role in the management of some advanced cases. Although the infections can be controlled, the vision of these patients is seriously damaged.
authors.affiliation: Department of Ophthalmology, Affiliated Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China.
authors.forename: L
authors.initials: L
authors.lastname: Lü
authors.forename: L
authors.initials: L
authors.lastname: Zou
authors.forename: R
authors.initials: R
authors.lastname: Wang
mesh_terms: D015823:Acanthamoeba Keratitis / Q000188:drug therapy / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D003261:Contact Lenses / Q000009:adverse effects*; D016039:Corneal Transplantation; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D015818:Eye Infections, Bacterial / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D009216:Myopia / Q000628:therapy; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents