Prolonged neurophysiological effects of cumulative wine drinking.
The effects of a single, large dose of alcohol have been studied extensively, but how alcohol affects the brain under more realistic social drinking situations has received scant attention. The neurophysiological effects of a cumulative dose of alcohol were investigated as subjects drank three glasses of alcoholic or placebo red wine, 1 h apart. In a double-blind procedure, electroencephalographic (EEG) activity was recorded for social drinkers during rest and performance of a working memory task at two levels of difficulty. Background EEG power in the theta, slow alpha, and beta bands increased with alcohol consumption. Along with this systemic increase in background cortical resonant activity, event-related potential (ERP) amplitudes decreased between 200 and 350 ms poststimulus and P300 latency increased, effects that occurred while relevant stimulus factors were being evaluated. These neurophysiological effects endured 3 h after drinking, whereas blood/breath alcohol concentration had decreased considerably and cognitive performance returned to normal. These findings seem to indicate that moderate social alcohol consumption has cumulative effects on brain function that persist for hours after chemical and behavioral indicators of intoxication have diminished. The results seem to indicate that neuronal populations needed for stimulus processing were less available after wine consumption (as evidenced by reduced ERP amplitudes) because of increased background oscillatory activity (as evidenced by increased background EEG power).
Ilan
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San Francisco Brain Research Institute & SAM Technology, 425 Bush Street, San Francisco, CA 94108, USA. aaron@eeg.com
Gevins
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D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects / Q000503:physiopathology*; D000435:Alcoholic Intoxication / Q000503:physiopathology; D000704:Analysis of Variance; D001944:Breath Tests; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects; D018913:Event-Related Potentials, P300 / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008568:Memory / Q000187:drug effects / Q000502:physiology; D009424:Nervous System Physiological Phenomena / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D014920:Wine