title: [Perioperative changes of plasma ET-1 in patients undergoing coronary artery bypass grafting and the effect of nitroglycerin].
abstract: OBJECTIVE
  To observe the dynamic changes of the plasma ET-1 and the effect of low dose nitroglycerin in patients with coronary artery bypass surgery.
  
  
  METHODS
  40 patients with coronary artery bypass surgery were divided into group A and B. Group B received intravenous nitroglycerin 1 microg x kg(-1) x min(-1) perioperatively. We used RIA to assay the plasma ET-1 level. All the hemodynamic parameters were recorded by the Swan-Ganz catheter.
  
  
  RESULTS
  The preoperative plasma ET-1 level in patients with coronary artery disease was significantly higher than the normal level. Five minutes after cardiopulmonary bypass in these patients the plasma ET-1 level was increased significantly until 6 to 8 hours after operation. The increased plasma ET-1 level in group B was less than in group A. There was a positive correlation between the plasma ET-1 level and the mean pulmonary pressure in group A 2 and 8 hours after operation.
  
  
  CONCLUSIONS
  In patients undergoing coronary artery bypass surgery, the increased plasma ET-1 level may be partly due to the influence of cardiopulmonary bypass. Low dose of nitroglycerin is beneficial to these patients.
authors.affiliation: Department of Cardiothoracic Surgery, Nanjing First Hospital, Nanjng Medical University, Nanjing 210006, China.
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Jiang
authors.forename: M
authors.initials: M
authors.lastname: Xu
authors.forename: H
authors.initials: H
authors.lastname: Bao
authors.forename: X
authors.initials: X
authors.lastname: Mu
authors.forename: L
authors.initials: L
authors.lastname: Xiao
authors.forename: Z
authors.initials: Z
authors.lastname: Guo
mesh_terms: D001026:Coronary Artery Bypass; D019332:Endothelin-1 / Q000097:blood*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*; D019990:Perioperative Care; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D019332:Endothelin-1; D014665:Vasodilator Agents; D005996:Nitroglycerin