title: Pleomorphic adenoma of the parotid gland with extensive bone formation.
abstract: We report an unusual case of pleomorphic adenoma with extensive bone formation, occurring in the parotid gland of a 58-year-old Japanese man. The tumor was a well-circumscribed mass that measured 20 x 20 x 15 mm and contained extensive bone formation. Histologically, most of the tumor was composed of bone and chondroid tissues. The bone formation with a marrow-like structure occupied half the volume of the tumor. The chondroid tissues merged continuously into bone tissues. The bone tissue seemed to be formed within areas of chondral tissue by a process of enchondral ossification. Except for the unusual amount of large bone formation, the tumor showed histology of pleomorphic adenoma, particularly at the periphery of the tumor. These histological findings suggest the possibility of extensive enchondral ossification in pleomorphic adenoma.
authors.affiliation: First Department of Pathology, Hiroshima University Faculty of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Shigeishi
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Takata
authors.forename: H
authors.initials: H
authors.lastname: Kuniyasu
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: W
authors.initials: W
authors.lastname: Yasui
mesh_terms: D008949:Adenoma, Pleomorphic / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D010307:Parotid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed