title: Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance.
abstract: The syntheses and SAR studies of various quinazolinone compounds are described for the dual inhibition of Pgp and MRP1 in multidrug resistance.
authors.affiliation: Department of Medicinal Chemistry, Xenova Ltd., 957 Buckingham Avenue, Slough, Berkshire SL1 4NL, UK. shouming_wang@xenova.co.uk
authors.forename: Shouming
authors.initials: S
authors.lastname: Wang
authors.forename: Hamish
authors.initials: H
authors.lastname: Ryder
authors.forename: Ian
authors.initials: I
authors.lastname: Pretswell
authors.forename: Paul
authors.initials: P
authors.lastname: Depledge
authors.forename: John
authors.initials: J
authors.lastname: Milton
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Hancox
authors.forename: Ian
authors.initials: I
authors.lastname: Dale
authors.forename: Wendy
authors.initials: W
authors.lastname: Dangerfield
authors.forename: Peter
authors.initials: P
authors.lastname: Charlton
authors.forename: Richard
authors.initials: R
authors.lastname: Faint
authors.forename: Rory
authors.initials: R
authors.lastname: Dodd
authors.forename: Stephanie
authors.initials: S
authors.lastname: Hassan
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D000903:Antibiotics, Antineoplastic / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D003630:Daunorubicin / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D004317:Doxorubicin / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D004347:Drug Interactions; D018432:Drug Resistance, Multiple; D006801:Humans; D020128:Inhibitory Concentration 50; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D011799:Quinazolines; D004317:Doxorubicin; D003630:Daunorubicin