title: Ki-67 expression in dentigerous cysts, unicystic ameloblastomas, and ameloblastomas arising from dental cysts.
abstract: This study investigated whether or not an ameloblastoma developing in the wall of a dentigerous cyst is a distinct lesion from the unicystic ameloblastoma. An immunohistochemical evaluation of Ki-67 in dentigerous cysts, unicystic ameloblastomas, and ameloblastomas arising in dentigerous cysts was done. The values of Ki-67 positivity were 3.14 for the dentigerous cyst, between 5.32 and 16.56 for unicystic ameloblastoma, and 11.77 for ameloblastoma arising in a dentigerous cyst. Statistically significant differences were found between the dentigerous cyst and the unicystic ameloblastoma and between the dentigerous cyst and the ameloblastoma arising from a dentigerous cyst. No statistically significant difference was present between unicystic ameloblastoma and ameloblastoma arising from dentigerous cyst. These immunohistochemical data confirm the hypothesis that an ameloblastoma arising from a dentigerous cyst has a similar biological behavior to the unicystic ameloblastoma and should be considered as merely a histologic variant.
authors.affiliation: Department of Oral Medicine and Pathology, Dental School, University of Chieti, Italy.
authors.forename: Adriano
authors.initials: A
authors.lastname: Piattelli
authors.forename: Giovanna
authors.initials: G
authors.lastname: Lezzi
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Fioroni
authors.forename: Alfredo
authors.initials: A
authors.lastname: Santinelli
authors.forename: Corrado
authors.initials: C
authors.lastname: Rubini
mesh_terms: D000328:Adult; D000564:Ameloblastoma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D003803:Dentigerous Cyst / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008875:Middle Aged; D018709:Statistics, Nonparametric
chemical_list: D019394:Ki-67 Antigen