Deadly encounter: ubiquitin meets apoptosis.
The ubiquitin/proteasome pathway is the main non-lysosomal route for intracellular protein degradation in eukaryotes. It is instrumental to various cellular processes, such as cell-cycle progression, transcription and antigen processing. Recent findings also substantiate a pivotal role of the ubiquitin/proteasome pathway in the regulation of apoptosis. Regulatory molecules that are involved in programmed cell death have been identified as substrates of the proteasome. Moreover, key regulators of apoptosis themselves seem to have an active part in the proteolytic inactivation of death executors.
Jesenberger
Veronika
V
Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18 a, 82152 Martinsried, Germany. Jesenber@biochem.mpg.de
Jentsch
Stefan
S
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000502:physiology; D003546:Cysteine Endopeptidases / Q000502:physiology; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D019476:Insect Proteins / Q000502:physiology; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000502:physiology; D016328:NF-kappa B / Q000502:physiology; D046988:Proteasome Endopeptidase Complex; D011506:Proteins; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D025801:Ubiquitin / Q000502:physiology*
D051034:Inhibitor of Apoptosis Proteins; D019476:Insect Proteins; D009097:Multienzyme Complexes; D016328:NF-kappa B; D011506:Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D025801:Ubiquitin; D020169:Caspases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex