Prophylaxia of cystine calculosis by alpha-mercaptopropionyl-glycine administered continuously or every other day.
We determined the efficacy of alpha-mercaptopropionyl-glycine administered in a low dosage continuously or every other day for prophylaxis of cystine calculosis. Two homozygous cystinuric patients with previous calculosis and renal unilateral hypoplasia and been given preventive treatment with alpha-mercaptopropionyl-glycine continuously administered in a low dosage (1.5-4 mg Kg-1 day-1 for 14 1/2 years and 10(-4) mg Kg-1 day-1 for 9 years respectively). Neither calculosis, nor side effects were observed. Subsequently, the patients were given 4 mg Kg-1 of the drug every second day for 1 and 1-2 years respectively without calculosis or side effect being observed. A low dosage of alpha-mercaptopropionyl-glycine(1.5-4 mg Kg-1 day-1) supplied continuously or, for a short time, 4 mg Kg-1 day-1 supplied every other day can be effective in the prophylaxis of cystine nephrolithiasis in some homozygous patients with renal unilateral hypoplasia, with lower risk of side effects.
Berio
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Cattedra di Pediatria, Università di Genova.
Piazzi
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D000328:Adult; D004334:Drug Administration Schedule; D006801:Humans; D020347:Lithiasis / Q000517:prevention & control*; D008297:Male; D008625:Tiopronin / Q000008:administration & dosage / Q000627:therapeutic use*
D008625:Tiopronin