Phytochemical and pharmacological analysis of Bauhinia microstachya (Raddi) Macbr. (Leguminosae).
This paper describes the isolation of four phytoconstituents from the leaves of Bauhinia microstachya, a Brazilian medicinal plant used in folk medicine for the treatment of several ailments. Based on spectroscopic evidence, these compounds were identified as methyl gallate (1), kaempferol 3-O-rhamnosyl (2), quercitrin (3) and myricitrin (4). The crude methanolic extract and two compounds (3 and 4) were tested as analgesic using the writhing test in mice. The extract and compound 3 caused potent and dose-related analgesic effects, confirming the popular use of this plant for the treatment dolorous processes.
Meyre-Silva
C
C
Departamento de Química, Universidade Federal de Santa Catarina UFSC, Florianópolis, SC, Brazil.
Yunes
R A
RA
Delle Monache
F
F
Santos
A R
AR
Schmeling
L O
LO
Gadotti
V M
VM
Liz
F
F
Cechinel-Filho
V
V
D000700:Analgesics / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001938:Brazil; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D044949:Kaempferols; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000700:Analgesics; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D044949:Kaempferols; C012526:quercitrin; C052082:methyl gallate; D005707:Gallic Acid; C006552:kaempferol; D011794:Quercetin