Effect of ethanol on hemorheology in patients with ischemic cerebrovascular disease and elderly healthy men.
Changes in hemorheological parameters were studied in patients with ischemic cerebrovascular disease and elderly healthy men who ingested ethanol at 0.5 and 1 g/kg body weight. Following ingestion of 1 g/kg, but not 0.5 g/kg of ethanol, there were significant changes in hemorheologic factors. Whole blood viscosity (WBV, shear rate: 18.8, 37.5, 75, 150, 350 sec(-1)) and blood viscosity corrected for hematocrit (BVC) were increased. WBV and BVC at high shear rate were increased and red blood cell deformability impaired in patients with ischemic cerebrovascular disease, while those factors were not significantly changed in healthy men. It is considered that ethanol ingestion could has bad influences for the microcirculation in patients with ischemic cerebrovascular disease.
Nagai
Y
Y
5th Department of Internal Medicine, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka-city 814-0180, Japan. yukik@urban.ne.jp
Ishida
K
K
Hirooka
M
M
Nishimaru
K
K
D000079:Acetaldehyde / Q000097:blood; D000368:Aged; D000428:Alcohol Drinking / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D001809:Blood Viscosity / Q000187:drug effects*; D002545:Brain Ischemia / Q000097:blood* / Q000188:drug therapy; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002544:Cerebral Infarction / Q000097:blood / Q000188:drug therapy; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004907:Erythrocyte Deformability / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D006400:Hematocrit; D006439:Hemodynamics / Q000187:drug effects; D018056:Hemorheology / Q000187:drug effects*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000188:drug therapy; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000188:drug therapy; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged
D001798:Blood Proteins; D002317:Cardiovascular Agents; D000431:Ethanol; D000079:Acetaldehyde