mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family.
The JAK/STAT signal transduction pathway controls numerous events in Drosophila melanogaster development. Receptors for the pathway have yet to be identified. Here we have identified a Drosophila gene that shows embryonic mutant phenotypes identical to those in the hopscotch (hop)/JAK kinase and marelle (mrl)/Stat92e mutations. We named this gene master of marelle (mom). Genetic analyses place mom's function between upd (the ligand) and hop. We further show that cultured cells transfected with the mom gene bind UPD and activate the HOP/STAT92E signal transduction pathway. mom encodes a protein distantly related to the mammalian cytokine receptor family. These data show that mom functions as a receptor of the Drosophila JAK/STAT signal transduction pathway.
Chen
Hua-Wei
HW
The Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.
Chen
Xiu
X
Oh
Su-Wan
SW
Marinissen
Maria J
MJ
Gutkind
J Silvio
JS
Hou
Steven X
SX
D000595:Amino Acid Sequence; D000818:Animals; D019521:Body Patterning; D002478:Cells, Cultured; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000196:embryology / Q000254:growth & development / Q000502:physiology*; D005091:Exons; D005260:Female; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism; D017403:In Situ Hybridization; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D007438:Introns; D053613:Janus Kinase 1; D053612:Janus Kinases; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D018121:Receptors, Cytokine / Q000235:genetics / Q000378:metabolism*; D050791:STAT Transcription Factors; D015398:Signal Transduction / Q000502:physiology*; D014132:Trachea / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors; D014162:Transfection
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D006023:Glycoproteins; D019476:Insect Proteins; D008565:Membrane Proteins; D018121:Receptors, Cytokine; D050791:STAT Transcription Factors; C105675:Stat92E protein, Drosophila; D015534:Trans-Activators; D014157:Transcription Factors; C103067:por protein, Drosophila; C115570:upd1 protein, Drosophila; D011505:Protein-Tyrosine Kinases; D053613:Janus Kinase 1; D053612:Janus Kinases; C085845:hop protein, Drosophila