Gut adaptation and the glucagon-like peptides.
The glucagon-like peptides GLP-1 and GLP-2 are synthesised and then released from enteroendocrine cells in the small and large intestine. GLP-1 promotes efficient nutrient assimilation while GLP-2 regulates energy absorption via effects on nutrient intake, gastric acid secretion and gastric emptying, nutrient absorption, and mucosal permeability. Preliminary human studies indicate that GLP-2 may enhance energy absorption and reduce fluid loss in subjects with short bowel syndrome suggesting that GLP-2 functions as a key regulator of mucosal integrity, permeability, and nutrient absorption. Hence GLP-2 may be therapeutically useful in diseases characterised by injury or dysfunction of the gastrointestinal epithelium.
Drucker
D J
DJ
The Banting and Best Diabetes Centre, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada M5G 2C4 d.drucker@utoronto.ca
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D005934:Glucagon / Q000502:physiology; D052216:Glucagon-Like Peptide 1; D053767:Glucagon-Like Peptide 2; D006801:Humans; D007410:Intestinal Diseases / Q000188:drug therapy; D007422:Intestines / Q000502:physiology*; D051379:Mice; D010446:Peptide Fragments / Q000502:physiology; D010455:Peptides / Q000502:physiology* / Q000627:therapeutic use; D011498:Protein Precursors / Q000502:physiology; D051381:Rats; D012778:Short Bowel Syndrome / Q000188:drug therapy
D053767:Glucagon-Like Peptide 2; D010446:Peptide Fragments; D010455:Peptides; D011498:Protein Precursors; D052216:Glucagon-Like Peptide 1; D005934:Glucagon