Resolution of recurrent perianal condylomata acuminata by topical cidofovir in patients with HIV infection.
Anogenital condylomata acuminata are the most frequent clinical manifestation of genital human papillomavirus (HPV) infection. Association between human immunodeficiency virus (HIV) and HPV infections is frequent (range: 26-60% in males). Topical cidofovir (a nucleotide analogue antiviral drug active against a broad range of DNA viruses) is a potential treatment for anogenital warts in immunocompromised patients. We treated three HIV-infected patients with HPV perianal condylomas with topical 1% cidofovir in flexible collodion once a day for 2 weeks. The treatment resulted in complete clearance of the HPV lesions. The patients experienced mild transient erythema without any other side-effects. None of the patients relapsed during the 10-14-month follow-up period.
Martinelli
C
C
Infectious Diseases Unit, Azienda Ospedaliera Careggi, Florence, Italy. fohle@tin.it
Farese
A
A
Mistro
A D
AD
Giorgini
S
S
Ruffino
I
I
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy*; D000287:Administration, Topical; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D000077404:Cidofovir; D003218:Condylomata Acuminata / Q000175:diagnosis / Q000188:drug therapy*; D003596:Cytosine / Q000008:administration & dosage* / Q000031:analogs & derivatives; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage*; D012008:Recurrence; D012720:Severity of Illness Index; D017193:Skin Diseases, Viral / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir