Benzylidene rhodanines as novel inhibitors of UDP-N-acetylmuramate/L-alanine ligase.
Benzylidene rhodanines are novel inhibitors of UDP N-acetylmuramate/L-alanine ligase. They showed selective whole-cell activity against the Gram-positive MRSA but not against the Gram-negative Escherichia coli. Their cytotoxic effect on mammalian CHO cells was also evaluated.
Sim
Mui Mui
MM
Medicinal and Combinatorial Chemistry Laboratory, Institute of Molecular and Cell Biology, 30Medical Drive, 117609, Singapore, Singapore. mcbsimmm@imcb.nus.edu.sg
Ng
Siew Bee
SB
Buss
Antony David
AD
Crasta
Sharon Carmelita
SC
Goh
Kah Lin
KL
Lee
Sue Kim
SK
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001597:Benzylidene Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D016466:CHO Cells / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010453:Peptide Synthases / Q000037:antagonists & inhibitors*; D012236:Rhodanine / Q000138:chemical synthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001597:Benzylidene Compounds; D004791:Enzyme Inhibitors; D012236:Rhodanine; D010453:Peptide Synthases; C023229:UDP-N-acetylmuramoyl-alanine synthetase