[Effect of a dopamine agonist on working memory in monkeys].
Prior to and after pharmacological effect of Agroclavine (a dopamine receptors' agonist) following its per os administration, its optimal dose (5 mg/kg) for cognitive processes was established in monkeys. Psychotropic effect of Agroclavine resulting in cognitive dysfunction manifested itself to a greater of lesser extent in all the experimental animals. Correctness of visual differentiation, probability of refusal to solve a task, time of a correct motor response were assumed as the behavioural criteria. In fact, all the animals revealed absence of any increase in the number of wrong solutions in visual differentiation or spatial choice, although the time of correct morot response and the number of refusal to solve the task mostly increased. The Agroclavine effect was found to be rather variable in respect to different types of visual information. A possible structural-functional organisation of the working memory processes is discussed.
Dudkin
K N
KN
G. K. Skriabin Institute of the Micro-Organisms Biochemistry and Physiology, Russian Acad. Sci., Moscow Region.
Chueva
I V
IV
Arinbasarov
M U
MU
Bobkova
N V
NV
D000818:Animals; D003071:Cognition / Q000187:drug effects; D018491:Dopamine Agonists / Q000494:pharmacology*; D004873:Ergolines / Q000494:pharmacology*; D008253:Macaca mulatta; D008570:Memory, Short-Term / Q000187:drug effects*; D009042:Motivation; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D014796:Visual Perception / Q000187:drug effects
D018491:Dopamine Agonists; D004873:Ergolines; C004465:agroclavine