title: New antidiabetic medications. Clinical evidence, clinical practice and pharmacoeconomics.
abstract: BACKGROUND
  Type 2 diabetes is a progressive and complex disease with underlying defects in insulin sensitivity, insulin secretion and hepatic glucose production. There is a range of antidiabetic treatment options now available to address these defects. Determination of which therapy for which patient is not always apparent from the clinical literature or the product information.
  
  
  OBJECTIVE
  To summarise the extent and use of clinical evidence, clinical practice and pharmacoeconomics in positioning antidiabetic agents in Australian clinical practice.
  
  
  CONCLUSIONS
  This paper summarises the introduction of new agents into the options for treatment of type 2 diabetes through the Pharmaceutical Benefits Scheme. Combining evidence based medicine, accepted clinical practice and decision analysis, allows the controlled introduction of new therapies in a climate of limited resources and a population with increasing therapeutic needs.
authors.affiliation: Eli Lilly Australia. graham-clarke_peita@lilly.com
authors.forename: P
authors.initials: P
authors.lastname: Graham-Clarke
authors.forename: K
authors.initials: K
authors.lastname: Mullen
mesh_terms: D001315:Australia; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D017850:Economics, Pharmaceutical; D006801:Humans; D007004:Hypoglycemic Agents / Q000191:economics*
chemical_list: D007004:Hypoglycemic Agents