Erythropoietic effects of space flight.
Various factors which are important in the regulation of erythropoiesis have been studied in dehydrated mice in the belief that some information would be gained relevant to the erythropoietic effects of space flight. Dehydration reduced the plasma volume and, because changes in red cell volume were minimal, the hematocrit was elevated. Thus a state of relative erythrocytosis was produced. Our understanding of the mechanism whereby these changes decreased red cell production is uncertain and appears to differ somewhat from the erythroid suppression seen following elevation of the hematocrit in animals with an absolute erythrocytosis. It is suggested that factors outside of the normal erythropoietic control pathway (such as energy balance) may play an important role in the decrease in red cell volume seen in man following space flight.
Dunn
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The Department of Medical Biology, The University of Tennessee Memorial Research Center, Knoxville, TN 37920, USA.
Lange
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RD
D000818:Animals; D001835:Body Weight; D001854:Bone Marrow Cells / Q000378:metabolism; D002478:Cells, Cultured; D003681:Dehydration / Q000097:blood* / Q000503:physiopathology; D004911:Erythrocyte Volume / Q000502:physiology*; D004920:Erythropoiesis / Q000502:physiology*; D005260:Female; D006400:Hematocrit; D006418:Heme / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D023421:Models, Animal; D010953:Plasma Volume / Q000502:physiology; D013026:Space Flight; D013154:Spleen / Q000166:cytology / Q000378:metabolism; D014893:Weightlessness
D006418:Heme