Pharmacological modulation of intracellular Ca(2+) channels at the single-channel level.
Synaptic signaling, memory formation, neuronal development, and neuronal pathology are strongly influenced by the properties of intracellular Ca2+ channels, ryanodine, and inositol 1, 4, 5 trisphosphate receptors. This review will focus on recently developed and discovered pharmacological tools to modulate these channel proteins at the single-channel level. It will allow the readers of Molecular Neurobiology to evaluate the current knowledge on the pharmacological modulation of intracellular Ca2+ channels and to direct future research efforts effectively using available experimental tools and concepts.
Koulen
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Department of Pharmacology and Neuroscience, University of North Texas, Fort Worth 76107-2699, USA. pkoulen@hsc.unt.edu
Thrower
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D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D000431:Ethanol / Q000494:pharmacology; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007424:Intracellular Fluid / Q000502:physiology; D009474:Neurons / Q000502:physiology; D011073:Polyamines / Q000494:pharmacology; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects / Q000502:physiology; D012430:Ruthenium Red / Q000494:pharmacology; D019837:Ryanodine Receptor Calcium Release Channel / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction; D013439:Sulfhydryl Reagents / Q000494:pharmacology; D013569:Synapses / Q000502:physiology*
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D011073:Polyamines; D018160:Receptors, Cytoplasmic and Nuclear; D019837:Ryanodine Receptor Calcium Release Channel; D013439:Sulfhydryl Reagents; D012430:Ruthenium Red; D000431:Ethanol