title: Manipulation of epitope function by modification of peptide structure: a minireview.
abstract: We have explored various approaches to modify the immunrecognition of linear peptides representing sequential or continuous topographic B-cell or T-cell epitopes. For these studies, epitopes from herpes simplex virus (HSV) glycoprotein D (gD) and from mucin 1 and mucin 2 glycoproteins or T-cell epitopes from 16 kDa and 38 kDa proteins of Mycobacterium tuberculosis were selected. To increase antigenicity and immunogenicity we have prepared cyclic and chimaeric peptide variants as well as epitope peptides with altered flanking regions and epitope-carrier conjugates containing multiple epitope copies.
authors.affiliation: Research Group of Peptide Chemistry, Hungarian Academy of Science, Eötvös L. University, Budapest 112, Hungary, H-1518. fhudecz@ludens.elte.hu
authors.forename: F
authors.initials: F
authors.lastname: Hudecz
mesh_terms: D000595:Amino Acid Sequence; D000939:Epitopes / Q000737:chemistry / Q000276:immunology*; D008969:Molecular Sequence Data; D011487:Protein Conformation
chemical_list: D000939:Epitopes