[The effects of inhaled bronchodilators on central inspiratory drive in patients with COPD].
OBJECTIVE
To evaluate the effects of inhaled bronchodilators on the central inspiratory drive in patients with COPD.


METHODS
91 patients with COPD were divided into three groups (A, B, C) randomly. Lung functions and P(0.1) were measured at baseline and 20 min and 60 min after inhalation (A: albuterol; B: iprotropium; C: albuterol + iprotropium).


RESULTS
P(0.1) decreased after inhalation in all three groups (P < 0.05 approximately 0.001). A positive correlation between DeltaP(0.1) and DeltaFRC was found in the three groups (r = 0.4325 - 0.5230, P < 0.05 approximately 0.01). V(E)/P(0.1) increased in the three groups after inhalation (P < 0.05 approximately 0.005). There was significant improvement of V(E)/P(0.1) in group B and C as compared with that of group A (P < 0.05, P < 0.001); There was a different correlative factor with V(E)/P(0.1) in group B and C.


CONCLUSIONS
(1) P(0.1) decreased after inhalation, It may be caused by decreased FRC. (2) V(E)/P(0.1) became appropriate after inhalation in all groups; The improvement in group B and C was superior to that of group A. There may be different mechanisms to improve V(E)/P(0.1) by different inhalators.
Yu
H
H
The Third Affiliated Hospital of Beijing Medical University, Beijing 100083.
Zhao
M
M
Yao
W
W
Qi
G
G
Zhao
C
C
D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D005260:Female; D005541:Forced Expiratory Volume; D005652:Functional Residual Capacity; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000503:physiopathology
D001993:Bronchodilator Agents