Analysis of mebendazole polymorphs by Fourier transform IR spectrometry using chemometric methods.
A diffuse reflectance IR Fourier transform IR spectrometry (DRIFTS) method was developed for the rapid, direct measurement of mebendazole in drugs. Conventional KBr spectra and DRIFTS spectra were compared for the best determination of the active substance in the drug formulations. Two chemometric approaches were used in the data processing: multicomponent partial least squares (PLS2) and principal component regression. The best results were obtained with the PLS2 method.
Aboul-Enein
Hassan Y
HY
Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist & Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia. enein@kfshrc.edu.sa
Bunaciu
Andrei A
AA
Fleschin
Serban
S
D000969:Antinematodal Agents / Q000032:analysis* / Q000737:chemistry; D016018:Least-Squares Analysis; D008463:Mebendazole / Q000032:analysis* / Q000737:chemistry; D012015:Reference Standards; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013607:Tablets / Q000737:chemistry
D000969:Antinematodal Agents; D013607:Tablets; D008463:Mebendazole