title: Poly(A) tail synthesis and regulation: recent structural insights.
abstract: Polyadenylation at the 3' ends of mRNAs is critical to the translation and stability of the messages. Recently determined structures of poly(A) polymerase, U1A and domains of the poly(A)-binding protein provide a framework for understanding the synthesis and regulation of the poly(A) tail.
authors.affiliation: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, MDF3-05, Research Triangle Park, NC 27709, USA. hall4@niehs.nih.gov
authors.forename: Traci M Tanaka
authors.initials: TM
authors.lastname: Hall
mesh_terms: D000818:Animals; D029968:Escherichia coli Proteins; D006801:Humans; D009690:Nucleic Acid Conformation; D011061:Poly A / Q000096:biosynthesis* / Q000737:chemistry; D039102:Poly(A)-Binding Proteins; D011062:Polynucleotide Adenylyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology; D011487:Protein Conformation; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000737:chemistry; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000502:physiology; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000737:chemistry / Q000502:physiology; D013329:Structure-Activity Relationship; D015003:Yeasts
chemical_list: D029968:Escherichia coli Proteins; D039102:Poly(A)-Binding Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D017412:Ribonucleoprotein, U1 Small Nuclear; C075339:U1A protein; D011061:Poly A; D011062:Polynucleotide Adenylyltransferase; C063643:pcnB protein, E coli