Rotavirus translation control protein takes RNA to heart.
Viruses commonly evolve distinct mechanisms to perform some of the same functions as cells. In the January 11 issue of Cell, Deo et al. describe the structure of rotavirus nonstructural protein 3 in complex with RNA, which explains how it acts as a functional homolog of cellular poly(A) binding protein to promote translation of the nonpolyadenylated rotavirus mRNAs.
Nibert
Max L
ML
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
D015967:Gene Expression Regulation, Viral; D008958:Models, Molecular; D014176:Protein Biosynthesis; D011487:Protein Conformation; D012367:RNA, Viral / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D012401:Rotavirus / Q000737:chemistry / Q000235:genetics; D017361:Viral Nonstructural Proteins / Q000737:chemistry* / Q000378:metabolism*
C082740:NSP3 protein, Rotavirus; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins