[Dose-effect of inhaled nitric oxide on pulmonary hypertension in inhaled injury in rabbits].
OBJECTIVE
To explore the relation of dose-response of NO inhalation in treatment of pulmonary hypertension in rabbits with smoke inhalation injury.


METHODS
The effect of various concentrations (1, 5, 10, 20, 30, 40, 50 and 60) x 10(-6) of NO on pulmonary hypertension after smoke inhalation injury was studied with right heart catheterization in 15 rabbits.


RESULTS
Mean pulmonary artery pressure (mPAP), pulmonary capillary wedge pressure (PCWP), pulmonary minute vessel pressure (Pmv), and pulmonary vascular resistance (PVR) were not changed remarkably (P > 0.05) after inhalation of (1 or 5) x 10(-6) NO. mPAP, PCWP, and Pmv were lowered significantly after inhalation of (10, 20, 30, 40, 50 and 60) x 10(-6) NO (P < 0.05, P < 0.01). Major vascular relaxation occurred when NO concentration was at 30 x 10(-6), and PVR did not further decrease along with the increase of NO concentration.


CONCLUSIONS
The concentration of inhaled NO should not exceed 30 x 10(-6) for the treatment of pulmonary hypertension in early stage of smoke inhalation.
Qi
S
S
Department of Burns and Plastic Surgery, Bethune International Peace Hospital, Shijiazhuang 050082.
Sun
Z
Z
Yang
J
J
D000280:Administration, Inhalation; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage*; D011817:Rabbits; D015208:Smoke Inhalation Injury / Q000150:complications*
D009569:Nitric Oxide