[An experimental study on effect of methazolamide on decreasing intraocular pressure in rabbits].
OBJECTIVE
To study the therapeutic effect of methazolamide on glaucoma.


METHODS
Various doses of methazolamide were orally administered in rabbits, their effects on high intraocular pressures and on recovery of low intraocular pressures were observed.


RESULTS
The high intraocular pressures were significantly decreased and the maintenance of low intraocular pressure was significantly prolonged by the oral administration of 40, 20, 10 mg/kg of methazolamide. A dose-effect relationship that is the reduction of intraocular pressure increases with the increase of the dosage administration of methazolamide could be observed.


CONCLUSIONS
This study indicates that methazolamide might play an effective therapeutic role in glaucoma.
Xu
H
H
Jiangsu Institute of Materia Medica, Nangjing 210009.
Yao
Q
Q
Zhou
G
G
D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005901:Glaucoma / Q000188:drug therapy*; D007429:Intraocular Pressure / Q000187:drug effects*; D008704:Methazolamide / Q000008:administration & dosage*; D015814:Ocular Hypotension / Q000188:drug therapy*; D011817:Rabbits
D002257:Carbonic Anhydrase Inhibitors; D008704:Methazolamide