Prevention of murine experimental autoimmune orchitis by recombinant human interleukin-6.
We studied the effect of exogenously administered recombinant human interleukin (IL)-6 on the development of experimental autoimmune orchitis (EAO) in C3H/Hej mice. IL-6 significantly reduced histological signs of EAO and appearance of delayed type hypersensitivity against the immunizing testicular germinal cells. The effect was seen even though the cytokine was administered for only 6 consecutive days and 2 weeks after immunization.
Li
Lu
L
Department of Internal Medicine, Kagawa Medical University, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Itoh
Masahiro
M
Ablake
Maila
M
Macrì
Battesimo
B
Bendtzen
Klaus
K
Nicoletti
Ferdinando
F
D000818:Animals; D006801:Humans; D015850:Interleukin-6 / Q000276:immunology / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009920:Orchitis / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control*; D011994:Recombinant Proteins / Q000276:immunology / Q000494:pharmacology; D013997:Time Factors
D015850:Interleukin-6; D011994:Recombinant Proteins