title: 2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.
abstract: A series of 2'-heteroaryl and 2'-oxime anilinomethylimidazolines was prepared and evaluated in in vitro functional assays for cloned human alpha1A, alpha1B, and alpha1D receptor subtypes. Potent and selective alpha1A agonists have been identified in these series.
authors.affiliation: Division of Chemistry, GlaxoSmithKline, 5Moore Drive, Research Triangle Park, NC 27709, USA. fn28689@gsk.com
authors.forename: Frank
authors.initials: F
authors.lastname: Navas
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bishop
authors.forename: Deanna T
authors.initials: DT
authors.lastname: Garrison
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Hodson
authors.forename: Jason D
authors.initials: JD
authors.lastname: Speake
authors.forename: Eric C
authors.initials: EC
authors.lastname: Bigham
authors.forename: David H
authors.initials: DH
authors.lastname: Drewry
authors.forename: David L
authors.initials: DL
authors.lastname: Saussy
authors.forename: James H
authors.initials: JH
authors.lastname: Liacos
authors.forename: Paul E
authors.initials: PE
authors.lastname: Irving
authors.forename: M Jeffrey
authors.initials: MJ
authors.lastname: Gobel
mesh_terms: D058646:Adrenergic alpha-1 Receptor Agonists; D000316:Adrenergic alpha-Agonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D020013:Calcium Signaling / Q000187:drug effects; D002460:Cell Line; D003001:Cloning, Molecular; D006571:Heterocyclic Compounds; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010091:Oximes; D010656:Phenylephrine / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism
chemical_list: C547713:ADRA1A protein, human; C547716:ADRA1B protein, human; C547719:ADRA1D protein, human; D058646:Adrenergic alpha-1 Receptor Agonists; D000316:Adrenergic alpha-Agonists; D006571:Heterocyclic Compounds; D007093:Imidazoles; D010091:Oximes; D018340:Receptors, Adrenergic, alpha-1; D010656:Phenylephrine