title: [Preclinical toxicological study of theraphthal-Lio and binary catalytic system "theraphthal-Lio+ascorbic acid"].
abstract: Pre-clinical toxicologic studies were conducted of a new drug teraphtal-Lio (TPh) and a teraphtal-Lio + ascorbic acid (TPh + AA) catalytic system recommended for binary catalytic therapy of malignant tumors. Quantitative criteria for "acute" and "chronic" toxicity of TPh and TPh + AA were established, which describe their toxic effects in single or multiple application. The coefficient of specific sensitivity and cumulation index for TPh and TPh + AA were determined. The toxicodynamic characteristics of TPh and TPh + AA were investigated. The results were used to prognose pulmonary, cardio-vascular, hemato- and hepatotoxic as well as hemodynamic and ophthalmologic disorders and functional changes in the central nervous system involved in clinical use of TPh and TPh + AA.
authors.affiliation: N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.
authors.forename: L M
authors.initials: LM
authors.lastname: Mikhaĭlova
authors.forename: O N
authors.initials: ON
authors.lastname: Koniaeva
authors.forename: E L
authors.initials: EL
authors.lastname: Chlenova
authors.forename: I B
authors.initials: IB
authors.lastname: Merkulova
authors.forename: N P
authors.initials: NP
authors.lastname: Ermakova
authors.forename: T N
authors.initials: TN
authors.lastname: Gavrilova
authors.forename: A A
authors.initials: AA
authors.lastname: Sergeev
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects / Q000633:toxicity*; D008297:Male; D051379:Mice; D011379:Prognosis; D051381:Rats; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; C403768:theraphthal