title: Third-generation progestogen type influences hemostatic changes caused by oral contraceptives in Brazilian women.
abstract: We compared the effects of two third-generation progestogens, desogestrel (DSG) and gestodene (GSD), on coagulation and fibrinolysis in Brazilian users of oral contraceptives (OCs). Forty-six women were evaluated before treatment and after six cycles of treatment. The coagulation, anticoagulant, and fibrinolytic systems were investigated. During the use of the DSG-containing OC, the activity of factors VII, VIII, IX, X, and XII increased significantly whereas the GSD-containing OC caused no changes in coagulation parameters. Concerning the anticoagulant pathways, the DSG-containing OC increased protein C levels and decreased total protein S levels, and the GSD-containing OC only decreased total protein S. Both OCs increased plasminogen activity, although the DSG-containing OC increased fibrin degradation products levels and decreased the tissue plasminogen activator antigen. In conclusion, we have found that in Brazilian women the effects of DSG and GSD on hemostatic parameters are different and, therefore, third-generation progestogens may not contribute equally to the thrombotic risk.
authors.affiliation: Department of Clinical, Toxicological and Bromatological Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil.
authors.forename: A C
authors.initials: AC
authors.lastname: Ferreira
authors.forename: M B
authors.initials: MB
authors.lastname: Montes
authors.forename: S A
authors.initials: SA
authors.lastname: Franceschini
authors.forename: M R
authors.initials: MR
authors.lastname: Toloi
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D001938:Brazil / Q000453:epidemiology; D020147:Coagulation Protein Disorders / Q000097:blood / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D003276:Contraceptives, Oral / Q000009:adverse effects; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D017135:Desogestrel / Q000008:administration & dosage / Q000494:pharmacology*; D005006:Ethnicity; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D009652:Norpregnenes / Q000008:administration & dosage / Q000494:pharmacology*; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic; D009652:Norpregnenes; D045167:Progesterone Congeners; C033273:Gestodene; D017135:Desogestrel