Mechanisms of transcription-coupled DNA repair.
Several types of helix-distorting DNA lesions block the passage of elongating RNA polymerase II. Surprisingly, such transcription-blocking lesions are usually repaired considerably faster than non-obstructive lesions in the non-transcribed strand or in the genome overall. In this review, our knowledge of eukaryotic transcription-coupled repair (TCR) will be considered from the point of view of transcription, and current models for the mechanism of TCR will be discussed.
Svejstrup
Jesper Q
JQ
Imperial Cancer Research Fund, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK. j.svejstrup@icrf.icnet.uk
D000818:Animals; D003057:Cockayne Syndrome / Q000235:genetics; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D008957:Models, Genetic; D009707:Nucleosomes / Q000502:physiology; D012319:RNA Polymerase II / Q000502:physiology; D014158:Transcription, Genetic; D015003:Yeasts / Q000235:genetics
D004268:DNA-Binding Proteins; D009707:Nucleosomes; D012319:RNA Polymerase II