Myotonia and keratoderma induced by 20,25 diazacholestenol.
A new inhibitor of cholesterol synthesis, 20,25 diazachlestenol, produced myotonia in 31 persons; and, in six of these, a keratoderma which resembles the natural disease, keratoderma climactericum. These observations further emphasize the importance of normal lipid synthesis in orderly cornification.
Anderson
P C
PC
Division of Dermatology, Cardiovascular Laboratory, University of Missouri Medical School, Columbia, USA.
Martt
J M
JM
D001373:Azacosterol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000139:chemically induced*; D008875:Middle Aged; D009222:Myotonia / Q000139:chemically induced*
D001373:Azacosterol