title: Regulation of chemosensory receptor expression and sensory signaling by the KIN-29 Ser/Thr kinase.
abstract: Sensory signals regulate multiple developmental and behavioral circuits in C. elegans, providing a genetically tractable system in which to investigate the mechanisms underlying the acquisition and integration of sensory information. kin-29 mutants are defective in the expression of a set of chemoreceptor genes, and exhibit characteristics associated with altered sensory signaling, including increased lifespan, decreased body size, and deregulated entry into the dauer developmental stage. kin-29 encodes a Ser/Thr kinase with similarity to the MARK and AMPK/SNF1 family of kinases. We show that KIN-29 acts cell-autonomously and non-cell-autonomously in sensory neurons to regulate chemoreceptor expression, body size, and the dauer decision, suggesting that kin-29 function is essential for the correct acquisition and transduction of sensory information.
authors.affiliation: Department of Biology and Volen Center for Complex Systems, Brandeis University, MS 008, 415 South Street, Waltham, MA 02454, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Lanjuin
authors.forename: Piali
authors.initials: P
authors.lastname: Sengupta
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D030801:Animals, Genetically Modified; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins; D002628:Chemoreceptor Cells / Q000502:physiology*; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D017930:Genes, Reporter; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D008017:Life Expectancy; D008969:Molecular Sequence Data; D009154:Mutation; D009475:Neurons, Afferent / Q000502:physiology*; D010675:Pheromones / Q000378:metabolism; D010802:Phylogeny; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D015398:Signal Transduction
chemical_list: D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; D010675:Pheromones; D011993:Recombinant Fusion Proteins; C448260:kin-29 protein, C elegans; D017346:Protein Serine-Threonine Kinases