title: Bypass of A- and B-signaling requirements for Myxococcus xanthus development by mutations in spdR.
abstract: Mutations in spdR, previously reported to bypass the developmental requirement for B-signaling in Myxococcus xanthus, also bypass the requirement for A-signaling but not C-, D-, or E-signaling. Mutations in spdR restored nearly wild-type levels of sporulation to representative A-signal-deficient mutants carrying asgA476, asgB480, and asgC767 and improved the quality of fruiting body formation in the asgB480 mutant. The defect in A-factor production by the asgB480 mutant was not restored in the spdR2134 asgB480 double mutant.
authors.affiliation: Department of Microbiology, University of Colorado Health Sciences Center, 4200 E. Ninth Street, Denver, CO 80262, USA.
authors.forename: Hubert
authors.initials: H
authors.lastname: Tse
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Gill
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D009154:Mutation; D016941:Myxococcus xanthus / Q000235:genetics / Q000254:growth & development*; D015398:Signal Transduction; D014157:Transcription Factors
chemical_list: D001426:Bacterial Proteins; C433529:SpdR protein, Myxococcus xanthus; D014157:Transcription Factors; C025035:A-factor (Streptomyces); D010450:Endopeptidases; C082110:BsgA protein, Myxococcus xanthus; D015107:4-Butyrolactone