title: Mechanism of response enhancement in evaporative light scattering detection with the addition of triethylamine and formic acid.
abstract: Triethylamine with an equimolar amount of formic acid added to the mobile phase provides an enhancement of the evaporative light scattering detector (ELSD) response. After characterization of the influence of various parameters on the ELSD response, a sequential strategy was defined to elucidate this response enhancement. The response enhancement was more marked at low mobile phase flow rate, and was highly dependent on solutes and solvents. The influence of drift tube temperature on response enhancement with various solutes demonstrated that triethylamine and formic acid mainly act as mass amplifiers by the inclusion of triethylamine-formic acid clusters inside the droplets.
authors.affiliation: Laboratoire de Chimie Analytique, Faculté de Pharmacie, Châtenay-Malabry, France. Frantz.Deschamps@cep.u-psud.fr
authors.forename: Frantz S
authors.initials: FS
authors.lastname: Deschamps
authors.forename: Arlette
authors.initials: A
authors.lastname: Baillet
authors.forename: Pierre
authors.initials: P
authors.lastname: Chaminade
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods; D005021:Ethylamines; D017022:Flow Injection Analysis; D005561:Formates; D008027:Light; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012542:Scattering, Radiation
chemical_list: D005021:Ethylamines; D005561:Formates; D004364:Pharmaceutical Preparations; C030544:formic acid; C016162:triethylamine