title: Myelin proteolipid protein--the first 50 years.
abstract: Myelin proteolipid protein (PLP), the most abundant protein of central nervous system (CNS) myelin, is a hydrophobic integral membrane protein. Because of its physical properties, which make it difficult to work with, progress towards determining the exact function(s) and disease associations of myelin PLP has been slow. However, recent molecular biology advances have given new life to investigations of PLP, and suggest that it has multiple functions within myelin and is of importance in several neurological disorders.
authors.affiliation: Department of Medicine, The University of Queensland, Brisbane, Clinical Sciences Building, Royal Brisbane Hospital, 4029, Qld, Herston, Australia. j.greer@medicine.uq.edu.au
authors.forename: Judith M
authors.initials: JM
authors.lastname: Greer
authors.forename: Marjorie B
authors.initials: MB
authors.lastname: Lees
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D018991:Myelin Proteolipid Protein / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D009422:Nervous System Diseases / Q000235:genetics* / Q000503:physiopathology; D017433:Protein Structure, Secondary
chemical_list: D018991:Myelin Proteolipid Protein