title: A new antibiotic CJ-17,665 from Aspergillus ochraceus.
abstract: A new antibiotic, CJ-17,665 (I) was isolated from the fermentation broth of Aspergillus ochraceus, CL41582. It inhibits growth of multi-drug resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 microg/ml, respectively. The structure contains a diketopiperazine and an indole N-oxide moiety that is unusual in natural products.
authors.affiliation: Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. Yutaka.Sugie@japan.pfizer.com
authors.forename: Y
authors.initials: Y
authors.lastname: Sugie
authors.forename: H
authors.initials: H
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Inagaki
authors.forename: M
authors.initials: M
authors.lastname: Ishiguro
authors.forename: Y J
authors.initials: YJ
authors.lastname: Kim
authors.forename: Y
authors.initials: Y
authors.lastname: Kojima
authors.forename: T
authors.initials: T
authors.lastname: Sakakibara
authors.forename: S
authors.initials: S
authors.lastname: Sakemi
authors.forename: A
authors.initials: A
authors.lastname: Sugiura
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: L
authors.initials: L
authors.lastname: Brennan
authors.forename: J
authors.initials: J
authors.lastname: Duignan
authors.forename: L H
authors.initials: LH
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Sutcliffe
authors.forename: N
authors.initials: N
authors.lastname: Kojima
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001235:Aspergillus ochraceus / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D013293:Enterococcus faecalis / Q000187:drug effects; D005285:Fermentation; D008401:Gas Chromatography-Mass Spectrometry; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D009904:Optical Rotation; D010879:Piperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D007659:Ketones; D010879:Piperazines