Hip1 and Hippi participate in a novel cell death-signaling pathway.
Neuronal apoptosis is a cardinal feature of late-onset neurodegenerative disorders such as Alzheimer's and Huntington's disease. Biochemical and cell biological studies point to a role for Hip1 and Hippi in caspase-8 activation and the initiation of apoptosis during the pathogenesis of Huntington's disease.
Wanker
Erich E
EE
Neuroproteomics Section, Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Str. 10, D-13125 Buch, Berlin, Germany.
D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction
D004268:DNA-Binding Proteins; C073368:HIP1 protein, human; D020169:Caspases