Combined effect of glutathione S-transferase M1 and T1 genotypes on bladder cancer risk.
To evaluate the association between genetic polymorphism of GSTM1, GSTT1 and development of bladder cancer, a hospital-based case-control study was conducted in South Korea. The study population consisted of 232 histologically confirmed male bladder cancer cases and 165 male controls enrolled from urology departments with no previous history of cancer or systemic diseases in Seoul during 1997-1999. The GSTM1 null genotype was significantly associated with bladder cancer (OR: 1.6, 95% CI: 1.0-2.4), whereas the association observed for GSTT1 null genotype did not reach statistical significance (OR: 1.3, 95% CI: 0.9-2.0). There was a statistically significant multiple interaction between GSTM1 and GSTT1 genotype for risk of bladder cancer (P=0.04); the risk associated with the concurrent lack of both of the genes (OR: 2.2, 95% CI: 1.2-4.3) was greater than the product of risk in men with GSTM1 null/GSTT1 present (OR: 1.3, 95% CI: 0.7-2.5) or GSTM1 present/GSTT1 null (OR: 1.1, 95% CI: 0.6-2.2) genotype combinations.
Lee
Seung Joon
SJ
Department of Internal Medicine, Hallym University College of Medicine, ChoonChun, South Korea.
Cho
Soo Hun
SH
Park
Sue Kyung
SK
Kim
Soo Woong
SW
Park
Moon Soo
MS
Choi
Han Yong
HY
Choi
Ji Yeob
JY
Lee
Sang Yoon
SY
Im
Hyoung June
HJ
Kim
Jae Yong
JY
Yoon
Ki Jung
KJ
Choi
Hwang
H
Shin
Sang Goo
SG
Park
Tae Won
TW
Rothman
Nathaniel
N
Hirvonen
Ari
A
Kang
Daehee
D
D000368:Aged; D000369:Aged, 80 and over; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000235:genetics*
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1