Vasopressin and epinephrine are equally effective for CPR in a rat asphyxia model.
Epinephrine has been administered as a drug essential for cardiopulmonary resuscitation (CPR). Recently, vasopressin has been reported to be more effective than epinephrine for CPR in a ventricular fibrillation (VF) model. As a different myocardial pathology is speculated to exist between the VF model and the asphyxia model, we investigated whether vasopressin is also effective in a rat asphyxia model. Twenty-one Sprague-Dawley male rats were divided into three groups: vasopressin 0.8 U/kg (Vaso-Gr), epinephrine 0.05 mg/kg (Epi-Gr), and saline same volume as the other two drugs (Sal-Gr). Five minutes after suffocation induced by obstruction of the tracheal tube, CPR was performed using each drug. Although only one animal survived (17%) in the Sal-Gr, 6/7 (85%) survived in both Vaso-Gr and Epi-Gr (P<0.01). Vasopressin is as effective as epinephrine for CPR in asphyxia-induced rats.
Kono
S
S
Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Handacho 3600, Hamamatsu, Shizuoka 431 3192, Japan. jo2qas@hama-med.ac.jp
Bito
H
H
Suzuki
A
A
Obata
Y
Y
Igarashi
H
H
Sato
S
S
D000818:Animals; D001237:Asphyxia / Q000401:mortality / Q000628:therapy*; D016887:Cardiopulmonary Resuscitation; D004837:Epinephrine / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*; D014667:Vasopressins / Q000627:therapeutic use*
D014662:Vasoconstrictor Agents; D014667:Vasopressins; D004837:Epinephrine