title: Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain.
abstract: The gene encoding human neuroblastoma apoptosis-related RNA binding protein (NAPOR) has rat and mouse homologues, Etr-r3 and mNapor, cloned recently by ourselves and others. Etr-r3/mNapor is transcribed in embryonic brain but its detailed expression patterns are unknown. It has been hypothesised that its expression coincides with the occurrence of programmed cell death, but existing expression data are insufficient to evaluate this possibility. We used northern blots and in situ hybridisation to show that Etr-r3/mNapor is expressed by most postmitotic differentiating cells throughout the forebrain during embryogenesis and the first weeks of postnatal life. Expression is particularly high in the developing cerebral cortex, in nuclei of the ventral telencephalon, in dorsal thalamus and in hypothalamus. In contrast, Etr-r3/mNapor is expressed by very few cells in proliferative regions, where cell death rates are highest.
authors.affiliation: Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK.
authors.forename: Teresa E
authors.initials: TE
authors.lastname: Levers
authors.forename: Steven
authors.initials: S
authors.lastname: Tait
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Birling
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Brophy
authors.forename: David J
authors.initials: DJ
authors.lastname: Price
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D000067878:CELF Proteins; D016923:Cell Death; D002454:Cell Differentiation; D002455:Cell Division; D002540:Cerebral Cortex / Q000196:embryology; D018076:DNA, Complementary / Q000378:metabolism; D007031:Hypothalamus / Q000196:embryology; D051379:Mice; D009419:Nerve Tissue Proteins; D016548:Prosencephalon / Q000196:embryology* / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics*; D051381:Rats; D013687:Telencephalon / Q000196:embryology; D013788:Thalamus / Q000196:embryology; D013997:Time Factors
chemical_list: D000067878:CELF Proteins; C117363:CELF2 protein, human; D018076:DNA, Complementary; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins