Statins and the risk of idiopathic venous thromboembolism.
OBJECTIVE
To evaluate the association between current statin use and the risk of idiopathic venous thromboembolism (VTE).


METHODS
A population-based retrospective follow-up with a nested case-control analysis using the General Practice Research Database.


RESULTS
There were 72 cases of idiopathic VTE. Using normolipidaemic nonuse as the reference group, the adjusted relative risks for idiopathic VTE for current/recent statin use, past statin use, past other lipid-lowering drug use, and hyperlipidaemic nonuse were 0.8 (0.3, 2.7), 2.4 (0.6, 10.0), 1.8 (0.4, 7.4), and 0.9 (0.4, 2.0) in the follow-up analysis, and were 1.1 (0.3, 4.3), 3.7 (0.6, 24.1), 2.0 (0.3, 11.6), and 0.4 (0.2, 1.2) in the case-control analysis.


CONCLUSIONS
Current statin use was not associated with a reduced risk of idiopathic VTE.
Yang
Chen-Chang
CC
Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
Jick
Susan S
SS
Jick
Hershel
H
D000328:Adult; D000368:Aged; D016001:Confidence Intervals; D004341:Drug Evaluation / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000188:drug therapy / Q000453:epidemiology; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors; D013923:Thromboembolism / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D020246:Venous Thrombosis / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents