title: A unique renal lesion in common variable immunodeficiency.
abstract: This article reports the case of a 33-year-old woman with common variable immunodeficiency (CVI) who developed renal failure 17 years after diagnosis and initiation of treatment with monthly IVIG. A renal biopsy revealed mesangial and paramesangial immune complex deposition and interstitial granulomatous infiltration. Renal function improved with oral corticosteroids, but did not return to normal. Decreasing the dose of IVIG had no effect on renal function. Immune dysfunction can be associated with both granulomatous disease and immune complex glomerulonephritis, or the latter may be related to chronic infection or immunoglobulin use. This is the first report of concomitant glomerular-tubulointerstitial lesions in this immunodeficiency syndrome. Renal function should be closely followed in patients with CVI.
authors.affiliation: University of Toronto, ON, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Stigant
authors.forename: D
authors.initials: D
authors.lastname: Sapir
authors.forename: J
authors.initials: J
authors.lastname: Sweet
authors.forename: G
authors.initials: G
authors.lastname: Downey
authors.forename: J M
authors.initials: JM
authors.lastname: Bargman
mesh_terms: D000328:Adult; D001706:Biopsy; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000473:pathology / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006099:Granuloma / Q000209:etiology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000473:pathology / Q000628:therapy
chemical_list: D016756:Immunoglobulins, Intravenous