title: Nutritional implications of chronic dyspepsia in childhood.
abstract: Chronic dyspepsia is common in children. However, the association of individual predominant symptoms with gastric emptying and their impact on nutritional status are poorly defined. We therefore studied 31 children (mean age 11 years, 14 boys) with chronic dyspepsia and classified their predominant symptoms (PS) by their character and severity. Gastric emptying (GE) T(1/2) of a solid meal was carried out in all patients, while upper gastrointestinal endoscopy was done in the treatment failures. All patients received two months treatment with cisapride. Weight for age z scores were recorded before and three months after treatment. There were 12 patients with epigastric pain (EP) as the PS (7 moderate/severe). Postprandial fullness (PF) was the PS in 19 patients (12 moderate/severe). GE T(1/2) was prolonged and weight for age z scores were lower in children who had moderate/severe (but not mild) PF comparing to those who had EP (P < 0.0001 and P = 0.003, respectively). A significant improvement in weight was observed in the same group alone following treatment with cisapride (P = 0.0003). In conclusion, impaired GE is common in dyspeptic children with PF and have adverse effects on nutritional status.
authors.affiliation: Department of Paediatrics, Faculty of Nursing, University of Athens, P & A Kyriakou Children's Hospital, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Papadopoulou
authors.forename: A
authors.initials: A
authors.lastname: Vazeou
authors.forename: C
authors.initials: C
authors.lastname: Siafakas
authors.forename: A
authors.initials: A
authors.lastname: Papadimitriou
authors.forename: C
authors.initials: C
authors.lastname: Bartsocas
mesh_terms: D001835:Body Weight; D002648:Child; D002908:Chronic Disease; D020117:Cisapride / Q000627:therapeutic use; D004415:Dyspepsia / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D008297:Male; D009752:Nutritional Status
chemical_list: D020117:Cisapride