title: One-step synthesis of substituted 6-amino-5-cyanospiro-4-(piperidine-4')- 2H,4H-dihydropyrazolo[3,4-b]pyrans.
abstract: Three-component condensation of 4-piperidinones (7), 5-pyrazolones (8), and malononitrile (4) proceeds chemically and electrochemically and is a convenient one-step means of synthesis of substituted 6-amino-5-cyanospiro-4-(piperidine-4')-2H,4H-dihydropyrazolo[3,4-b]pyrans (12). The electrochemical reactions proceed under milder conditions and with yields 12-15% greater than those of the reactions catalyzed by chemical bases.
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 117913 Moscow, Russia.
authors.forename: Anatoliy M
authors.initials: AM
authors.lastname: Shestopalov
authors.forename: Yuliya M
authors.initials: YM
authors.lastname: Emeliyanova
authors.forename: Aleksandr A
authors.initials: AA
authors.lastname: Shestopalov
authors.forename: Lyudmila A
authors.initials: LA
authors.lastname: Rodinovskaya
authors.forename: Zukhra I
authors.initials: ZI
authors.lastname: Niazimbetova
authors.forename: Dennis H
authors.initials: DH
authors.lastname: Evans