[Hepatic arterial infusion of 32P-radionuclide microspheres for radiation therapy of hepatocellular carcinoma].
OBJECTIVE
To investigate the efficacy of internal radiation of (32)P-glass microspheres ((32)P-GMS) in unresected hepatocellular carcinoma (HCC) via subcutaneous arterial port.


METHODS
Hepatic arterial (99)technetium-macroaggregate albumin ((99)Tc-MAA) scanning via subcutaneous arterial port was undertaken to measure lung/liver shunting ratio and tumor/liver ratio. Hepatic arterial infusion of (32)P-GMS was performed in 17 cases of HCC with a dose from 1.11 to 1.30 GBq. Twenty cases of HCC undergoing hepatic arterial chemoembolization (HACE) in the same period served as controls group.


RESULTS
There was no treatment-related death in the 17 cases. In 7 of the 17 cases, AFP level and/or tumor size decreased by 50% after treatment, with a response rate of 64.7%. The median survival time was 5.5 months, and the 3-, 6-, 9-, 12-month survival rates were 94.1%, 44.1%, 31.0%, 24.4%, respectively. The therapeutic efficacy was better than that of HACE. The survival time was significantly longer in patients with T/N ratio >or= 2 than in those with T/N < 2 (P < 0.05).


CONCLUSIONS
Hepatic arterial infusion of (32)P-GMS is an alternative treatment for unresected HCC.
Liang
L
L
Department of Hepatobiliary Surgery, First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510080.
Huang
J
J
Yin
X
X
Lu
M
M
Rao
G
G
Ren
Z
Z
Li
D
D
Kuang
M
M
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D010761:Phosphorus Radioisotopes / Q000008:administration & dosage*; D015996:Survival Rate; D000509:alpha-Fetoproteins / Q000378:metabolism
D010761:Phosphorus Radioisotopes; D000509:alpha-Fetoproteins