[Expression and significance of human leukocyte antigen DR and intercellular adhesion molecule-1 in normal and pathological corneas].
OBJECTIVE
To study the expression of human leukocyte antigen DR (HLA-DR) and intercellular adhesion molecule-1 (ICAM-1) in normal and pathological corneas and their significance in corneal inflammation and rejection after keratoplasty.


METHODS
The expression of HLA-DR and ICAM-1 were detected in 10 normal corneas and 48 pathological corneas by using immunohistochemical techniques.


RESULTS
HLA-DR and ICAM-1 were not expressed or only slightly expressed in normal corneas and markedly expressed in pathological corneas, especially in inflammatory corneas. In general, HLA-DR and ICAM-1 were co-expressed in similar regions. The expression rates of HLA-DR and ICAM-1 in the 7 cases of keratoplasty rejection were higher than that in the 21 cases of non-rejection.


CONCLUSIONS
The overexpression of HLA-DR and ICAM-1 is related to corneal inflammation and can promote the occurrence of keratoplasty rejection.
Gu
Y
Y
Department of Ophthalmology, First Hospital of Zhejiang University, Hangzhou 310003.
Wang
J
J
D000293:Adolescent; D000328:Adult; D003315:Cornea / Q000378:metabolism*; D003316:Corneal Diseases / Q000378:metabolism*; D005260:Female; D006684:HLA-DR Antigens / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged
D006684:HLA-DR Antigens; D018799:Intercellular Adhesion Molecule-1