[The effects of the complex of rhBMP2 and fibrin sealant on dental pulp].
OBJECTIVE
To investigate the reparative dentine formation induced by the complex of recombinant human bone morphogenetic protein 2 (rhBMP2) and fibrin sealant (FS) in dog tooth.


METHODS
Freshly exposed molars, premolars and cuspids were treated with the complex of rhBMP2/FS, rhBMP2 and Ca(OH)(2) paste which served as control.


RESULTS
The wound healing of exposed pulp treated with FS seemed to be better than that without FS. Dentine bridge formation was observed in pulp treated with the complex at 7 days, with rhBMP2, Ca(OH)(2) at 28 days. At 63 days after operation, the cases of tubular dentine bridge formation of the pulp treated with the complex were more than that of pulp treated with rhBMP2.


CONCLUSIONS
The synergistic effects of FS and the complex rhBMP2 exist and can be used as bioactive pulp capping agent.
Ren
W
W
Department of Oral Pathology, School of Stomatology, Fourth Military Medical University, Xi'an 710032, China.
Yang
L
L
Dong
S
S
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D003785:Dental Pulp Capping / Q000379:methods; D003809:Dentin, Secondary / Q000187:drug effects* / Q000254:growth & development; D004285:Dogs; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D015718:Fibrin Tissue Adhesive; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta