[Chemotherapeutic failure in micrometastasis in peripheral blood of patients with colorectal carcinomas].
OBJECTIVE
To study chemotherapeutic failure in the micrometastasis in peripheral blood of patients with colorectal carcinomas and its clinical significance.


METHODS
We investigated the changes of micrometastasis in peripheral blood of patients with colorectal carcinomas before and after chemotherapy.


RESULTS
The positive rate of CK2O mRNA in peripheral blood was 58.3%. Five more positive cases were detected 3 days after operation than before operation. After early short-term chemotherapy following operation, 22 cases turned to be negative. The maintaince of micrometastasis in peripheral blood after chemotherapy was significantly related to bcl-2 expression and p53 mutation in cancer tissues.


CONCLUSIONS
The early short-term chemotherapy after operation plays a role in controlling the micrometastasis of colorectal carcinoma. The study of chemotherapeutic effect on micrometastasis in peripheral blood and its relation with the related genes may contribute to the selection of drugs and plans of adjuvant treatment.
Luo
C
C
Department of General Surgery, Beijing General Hospital, People's Liberation Army, Beijing 100700.
Li
S
S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D007381:Intermediate Filament Proteins / Q000097:blood*; D053554:Keratin-20; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D012333:RNA, Messenger / Q000097:blood; D017211:Treatment Failure; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D007381:Intermediate Filament Proteins; C507499:KRT20 protein, human; D053554:Keratin-20; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D016159:Tumor Suppressor Protein p53