title: Efficacy of ravuconazole in treatment of systemic murine histoplasmosis.
abstract: Ravuconazole (RCZ) was evaluated for efficacy in comparison to fluconazole (FCZ) and itraconazole (ITZ) in murine models of disseminated histoplasmosis. All regimens tested prolonged survival (P < 0.05 to 0.0001). At equivalent doses of 50 mg/kg of body weight, RCZ and ITZ were equally effective and RCZ was more effective than FCZ (P = 0.02). Clearance of fungal burden from the livers and spleens of mice showed RCZ and ITZ at doses of 50 mg/kg to be efficacious but not curative. These data indicate that RCZ should be studied further.
authors.affiliation: California Institute for Medical Research. Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128, USA. clemons@cimr.org
authors.forename: K V
authors.initials: KV
authors.lastname: Clemons
authors.forename: M
authors.initials: M
authors.lastname: Martinez
authors.forename: L
authors.initials: L
authors.lastname: Calderon
authors.forename: D A
authors.initials: DA
authors.lastname: Stevens
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006660:Histoplasmosis / Q000188:drug therapy* / Q000382:microbiology; D017964:Itraconazole / Q000627:therapeutic use; D008099:Liver / Q000382:microbiology; D051379:Mice; D013154:Spleen / Q000382:microbiology; D013534:Survival; D016019:Survival Analysis; D013844:Thiazoles / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D013844:Thiazoles; D014230:Triazoles; D017964:Itraconazole; D015725:Fluconazole; C104066:ER 30346