Idiopathic myelofibrosis with extramedullary haemopoiesis involving the urinary bladder in a Chinese lady.
Extramedullary haemopoiesis (EMH) associated with idiopathic myelofibrosis most commonly involves the reticuloendothelial organs, such as the spleen and liver, although ectopic haemopoietic tissue has also been described rarely in the lymph nodes, skin, gastrointestinal tract, pleura, peritoneum, central nervous system, and genital and urinary tracts. We report on a 54-year-old Chinese lady with a long history of idiopathic myelofibrosis who presented with gross haematuria and left hydronephrosis due to EMH in the bladder trigone. Cystoscopic examination revealed a sessile necrotic papillary growth at the trigone, obstructing the left ureteric orifice. Transurethral resection of the bladder tumour was performed, and microscopic examination of the tumour chips demonstrated atypical megakaryocytes, immature granulocytes and normoblasts, confirming the presence of EMH. The residual bladder tumour responded well to low dose radiotherapy, with subsequent disappearance of haematuria and normalization of ultrasonogram findings.
Mak
Y K
YK
Department of Medicine, Queen Elizabeth Hospital, Kowloon, China.
Chan
C H
CH
So
C C
CC
Chan
M K
MK
Chu
Y C
YC
D019070:Cell Lineage; D005260:Female; D006411:Hematopoiesis, Extramedullary / Q000528:radiation effects; D006801:Humans; D008213:Lymphocyte Activation; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000209:etiology / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000473:pathology* / Q000532:radiotherapy