title: A low serum sICAM-1 level may assist in the exclusion of neonatal infection.
abstract: Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in 46 samples from 46 infants undergoing intensive care were studied. Residual serum remaining after routine electrolyte analysis was utilised. sICAM-1 levels were determined by ELISA. Blind retrospective chart review was employed to determine whether infants were infected. Serum levels were significantly elevated in infants with proven and probable infection, compared with non-infected infants (p < 0.001). sICAM-1 levels in serum were comparable to levels previously established in plasma samples. The results suggest that serum sICAM-1 measurement is a simple and robust test that differentiates infected from non-infected infants and that a low level of serum sICAM-1 may particularly assist in the exclusion of infection.
authors.affiliation: Regional Immunology Service, Royal Hospitals Trust, Belfast, UK. david-edgar@bll.n-i.nhs.uk
authors.forename: David
authors.initials: D
authors.lastname: Edgar
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gabriel
authors.forename: Adam
authors.initials: A
authors.lastname: Craig
authors.forename: Darren
authors.initials: D
authors.lastname: Wheeler
authors.forename: Moira
authors.initials: M
authors.lastname: Thomas
authors.forename: Judith
authors.initials: J
authors.lastname: Grant
mesh_terms: D001424:Bacterial Infections / Q000097:blood* / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D012189:Retrospective Studies
chemical_list: D018799:Intercellular Adhesion Molecule-1