1-tert-butoxy-2-tert-butoxycarbonyl-1,2-dihydroisoquinoline: a novel and chemoselective tert-butoxycarbonylation reagent.
[reaction: see text] The use of 1-tert-butoxy-2-tert-butoxycarbonyl-1,2-dihydroisoquinoline (BBDI) as tert-butoxycarbonylation reagent for aromatic and aliphatic amine hydrochlorides and phenols in the absence of a base has been demonstrated. The reactions proceed chemoselectively in high yield under mild conditions.
Ouchi
Hidekazu
H
Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
Saito
Yukako
Y
Yamamoto
Yutaka
Y
Takahata
Hiroki
H