Calculating the potential of C2 domains for membrane binding.
A recent report in Molecular Cell demonstrates the ability of electrostatic calculations to predict the membrane binding properties of structurally characterized C2 domains and assign probable membrane targeting functions to numerous uncharacterized C2 domains.
Merithew
Eric
E
Program in Molecular Medicine, Department of Biochemistry and Molecular, Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Lambright
David G
DG
D001665:Binding Sites; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D002135:Calcium-Binding Proteins; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D011493:Protein Kinase C / Q000737:chemistry / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000187:drug effects; D055672:Static Electricity; D050857:Synaptotagmins
D002135:Calcium-Binding Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D050857:Synaptotagmins; D011493:Protein Kinase C; D002118:Calcium