The genetic background of medullary thyroid carcinoma in young patients.
The study was undertaken to evaluate the frequency of RET polymorphisms at codons 769 and 836 in young medullary thyroid carcinoma (MTC) patients in whom the presence of a known germline mutation has been excluded. 40 patients aged 10-29 were subjected to genetic analysis of RET exons 10, 11, 13, 14 and 16 and compared to 140 older patients. The hereditary component occurred to be very high in young MTC patients: 57% carry the germline mutation, other 28% exhibit at least one rare polymorphic variant of RET. The observed allelic frequencies were 38% for polymorphic variant L769CTG and 6% for variant S836AGT. The results were significantly higher than those obtained in the group of older patients: 20% and 1% for L769CTG and S836AGT, respectively. Our results speak in favour that the polymorphism in RET codon 769 and 836 may also be a factor predisposing to the development of MTC in young age.
Wiench
M
M
Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial Institute, Gliwice, Poland.
Wygoda
Z
Z
Gubała
E
E
Włoch
J
J
Oczko
M
M
Jarzab
B
B
D000328:Adult; D000367:Age Factors; D018276:Carcinoma, Medullary / Q000235:genetics*; D002648:Child; D029721:Drosophila Proteins; D005091:Exons; D005787:Gene Frequency; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000235:genetics*
D029721:Drosophila Proteins; D011518:Proto-Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila