Reactive dienes: intramolecular aromatic oxidation of 3-(2-hydroxyphenyl)-propionic acids.
[reaction: see text] Treatment of 3-(2-hydroxyphenyl)-propionic acids with a hypervalent iodine reagent in the presence of a dienophile initiates a tandem intramolecular aromatic oxidation/Diels-Alder reaction. Herein we report (1) investigations on the scope and limitations of this novel reaction combination and (2) preliminary diastereoselectivity studies using alpha- and beta-substituted acids.
Drutu
Ioana
I
Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.
Njardarson
Jón T
JT
Wood
John L
JL