title: Reaction of 1-alkylthioisoquinolinium salts with active methylene compounds.
abstract: 2-Alkyl-1-alkylthioisoquinolinium salts were readily prepared from 2-alkyl-1(2H)-isoquinolones via 2-alkyl1(2H)-thioisoquinolones in two steps. Under mild conditions, the reaction of 2-alkyl-1-alkylthioisoquinolinium salts with active methylene compounds in the presence of sodium hydride afforded 2-alkyl-1-(substituted methylene)iso-quinolines in good yields. Pyrrolo[2,1-a]isoquinolines were synthesized by the cyclization of 2-benzyl-1-(substituted methylene)isoquinolines using acetic anhydride.
authors.affiliation: Tohoku Pharmaceutical University, Sendai, Japan. refujita@tohoku-pharm.ac.jp
authors.forename: Reiko
authors.initials: R
authors.lastname: Fujita
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Watanabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomisawa
mesh_terms: D006838:Hydrocarbons; D007546:Isoquinolines / Q000138:chemical synthesis*; D008697:Methane / Q000031:analogs & derivatives*
chemical_list: D006838:Hydrocarbons; D007546:Isoquinolines; C030011:carbene; D008697:Methane