title: In search of a 9q13 latent centromere in 9qh polymorphic inversions.
abstract: In search of a 9q13 latent centromere in 9qh polymorphic inversions: The presence of alphoid sequences in 9q13 has prompted the suggestion that such a region could harbor a latent centromere which under certain circumstances may appear as a neocentromere. We tested this hypothesis by means of FISH with a centromere 9-specific alphoid probe in lymphocyte metaphases from 13 unrelated individuals with a 9qh polymorphic inversion. Since all inverted chromosomes had the alphoid signal onto the primary constriction, it was not possible to identify any neocentromere . We believe, however, that the number of cases was not enough to conclude that all the polymorphic inversions of chromosome 9 are genuine.
authors.affiliation: Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jal.
authors.forename: M
authors.initials: M
authors.lastname: Gutiérrez-Angulo
authors.forename: A I
authors.initials: AI
authors.lastname: Vásquez
authors.forename: A L
authors.initials: AL
authors.lastname: Ramos
authors.forename: M G
authors.initials: MG
authors.lastname: Domínguez
authors.forename: J R
authors.initials: JR
authors.lastname: González-García
authors.forename: H
authors.initials: H
authors.lastname: Rivera
mesh_terms: D001483:Base Sequence; D002503:Centromere; D007446:Chromosome Inversion; D002899:Chromosomes, Human, Pair 9; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers