Clonally unrelated Hodgkin's disease following autologous stem cell transplant for B-cell lymphoma.
Lymphoproliferative disorders after autologous stem cell transplantation (SCT) are rare. We describe two cases of Hodgkin's disease (HD) as a late secondary neoplasia following autologous SCT for mantle cell lymphoma and B-cell chronic lymphocytic leukaemia respectively. Both HD cases were of mixed cellularity type, showed Epstein-Barr virus (EBV) positivity and followed an aggressive course. Clonal analysis of rearranged immunoglobulin genes from the primary B-cell neoplasm and the secondary HD provided evidence of separate clonal origins of the two tumours in both patients, thus excluding secondary transformation of the original B-cell clone through EBV as the causative event for development of HD.
Fend
Falko
F
Department of Pathology, Technical University Munich and GSF National Research Center for Environment and Health Neuherberg, Munich, Germany. fend@lrz.tum.de
Martinez
Antonio
A
Quintanilla-Martinez
Leticia
L
Sanz
Llucia
L
Combalia
Neus
N
Raffeld
Mark
M
Jaffe
Elaine S
ES
Montserrat
Emilio
E
Campo
Elias
E
D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000150:complications* / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000276:immunology / Q000601:surgery*; D020522:Lymphoma, Mantle-Cell / Q000150:complications / Q000276:immunology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000276:immunology*; D016133:Polymerase Chain Reaction; D014182:Transplantation, Autologous