title: Prevalence of IgG antibodies to human parvovirus B19 in haemophilia children treated with recombinant factor (F)VIII only or with at least one plasma-derived FVIII or FIX concentrate: results from the French haemophilia cohort.
abstract: Human parvovirus B19 (B19) has been transmitted by some brands of virally attenuated plasma-derived factor VIII (FVIII) or IX (FIX) concentrates. To quantify the differences of human parvovirus B19 risk transmission between albumin-stabilized recombinant factor and plasma-derived factor, we studied the prevalence of IgG antibodies to B19 (anti-B19) in 193 haemophiliac children between 1 and 6-years of age who had previously been treated with albumin-stabilized recombinant FVIII only (n = 104), and in children previously treated with solvent/detergent high-purity non-immunopurified and non-nanofiltered FVIII or IX concentrates (n = 89). Association between the prevalence of anti-B19 and the treatment group was analysed using multivariate logistic regression. Age, severity and type of haemophilia, number of cumulative days of exposure to factor VIII or IX, previous history of red blood cells or plasma transfusion were considered as potential confounding variables. A higher prevalence of anti-B19 was found in children previously treated with solvent/detergent high-purity non-immunopurified and non-nanofiltered FVIII or IX concentrates than in children treated with albumin- stabilized recombinant FVIII only (OR: 22.3; CI: 7.9-62.8), independently of the other factors studied.
authors.affiliation: Inserm SC4, Faculté de médecine de Saint-Antoine, Paris, France. gaboulaud@b3e.jussieu.fr
authors.forename: Valérie
authors.initials: V
authors.lastname: Gaboulaud
authors.forename: Armelle
authors.initials: A
authors.lastname: Parquet
authors.forename: Cedric
authors.initials: C
authors.lastname: Tahiri
authors.forename: Ségolène
authors.initials: S
authors.lastname: Claeyssens
authors.forename: Valérie
authors.initials: V
authors.lastname: Potard
authors.forename: Albert
authors.initials: A
authors.lastname: Faradji
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Peynet
authors.forename: Dominique
authors.initials: D
authors.lastname: Costagliola
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D001803:Blood Transfusion; D017848:Blood-Borne Pathogens; D002648:Child; D002675:Child, Preschool; D005164:Factor IX / Q000627:therapeutic use*; D005169:Factor VIII / Q000627:therapeutic use*; D006467:Hemophilia A / Q000628:therapy* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D016015:Logistic Models; D008297:Male; D010322:Parvoviridae Infections / Q000635:transmission*; D016732:Parvovirus B19, Human / Q000276:immunology*; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D011994:Recombinant Proteins; D005169:Factor VIII; D005164:Factor IX