title: Effect of Acanthopanax senticosus stem on mast cell-dependent anaphylaxis.
abstract: We studied the effect of Acanthopanax senticosus stem (ACPS) on mast cell-dependent anaphylaxis. ACPS inhibited compound 48/80-induced systemic anaphylaxis at a dose of 1.0 g/kg by 50%. ACPS also inhibited passive cutaneous anaphylaxis reaction and histamine release from mast cells in a dose-dependent manner, respectively. Moreover, ACPS had an inhibitory effect on anti-dinitrophenyl IgE-induced tumor necrosis factor-alpha (TNF-alpha) production from mast cells. These results indicate that ACPS inhibits mast cell-mediated anaphylaxis in vivo and in vitro murine model.
authors.affiliation: Department of Oriental Pharmacy, College of Pharmacy, Korea Institute of Oriental Pharmacy, Wonkwang University, Iksan, Chonbuk 570-749, South Korea.
authors.forename: Jin Mu
authors.initials: JM
authors.lastname: Yi
authors.forename: Seung Heon
authors.initials: SH
authors.lastname: Hong
authors.forename: Jong Ha
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyeong Kyun
authors.initials: HK
authors.lastname: Kim
authors.forename: Ho Joon
authors.initials: HJ
authors.lastname: Song
authors.forename: Hyung Min
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D028001:Eleutherococcus / Q000502:physiology*; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018547:Plant Stems / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D003189:p-Methoxy-N-methylphenethylamine