Synthesis, characterization and antitumor studies of Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) complexes of N-salicyloyl-N'-o-hydroxythiobenzhydrazide.
A new ligand N-salicyloyl-N'-o-hydroxythiobenzhydrazide (H2Sotbh) forms complexes [Mn(HSotbh)2], [Fe(Sotbh-H)(H2O)2], [M(Sotbh)] [M=Co(II), Cu(II) and Zn(II)] and [Ni(Sotbh)(H(2)O)2], which were characterized by various physico-chemical techniques. Mössbauer spectrum of [Fe(Sotbh-H)(H2O)2] reveals the quantum admixture of 5/2 and 3/2 spin-states. Mn(II), Cu(II) and Ni(II) complexes were observed to inhibit the growth of tumor in vitro, whereas, Fe(III), Co(II), Zn(II) complexes did not. In vivo administration of Mn(II), Cu(II) and Ni(II) resulted in prolongation of survival of tumor bearing mice. Tumor bearing mice administered with Mn(II), Cu(II) and Ni(II) complexes showed reversal of tumor growth associated induction of apoptosis in lymphocytes. The paper discusses the possible mechanisms and therapeutic implication of the H2Sotbh and its metal complexes in tumor regression and tumor growth associated immunosuppression.
Shrivastav
Anuraag
A
Department of Chemistry, Faculty of Science, Banaras Hindu University, 221005, Varanasi, India. anuraagshrivastav@yahoo.com
Singh
Nand K
NK
Singh
Sukh Mahendra
SM
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D006834:Hydrazines / Q000737:chemistry / Q000494:pharmacology*; D008024:Ligands; D008345:Manganese / Q000737:chemistry; D019216:Metals, Heavy / Q000737:chemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D015204:Spectroscopy, Mossbauer; D014407:Tumor Cells, Cultured; D015032:Zinc / Q000737:chemistry
D000970:Antineoplastic Agents; D006834:Hydrazines; D008024:Ligands; D019216:Metals, Heavy; C464980:N-salicyloyl-N'-o-hydroxythiobenzhydrazide; D009942:Organometallic Compounds; D003035:Cobalt; D008345:Manganese; D003300:Copper; D009532:Nickel; D015032:Zinc