title: Pore formation in tablets compressed from binary mixtures as a result of deformation and relaxation of particles.
abstract: This paper describes the internal structure of tablets compressed from binary mixtures of sodium chloride and pregelatinised starch. The minimum particle diameter of pregelatinised starch inside tablets compressed from mixtures was calculated from the difference between the initial pore size distribution and the pore size distribution after removal of the starch particles by burning. Subsequently, the tablets were carefully crushed. These powders, consisting of almost only sodium chloride particles, were measured by laser diffraction. It was found that the diameter of the sodium chloride particles hardly changed, whereas the minimum diameter of starch particles strongly decreased during the compaction process. As an effect of the difference in yield pressure, the harder sodium chloride particles cause deformation of the softer starch particles, resulting in a change in particle shape. The pore size distribution of tablets compressed from mixtures of sodium chloride and starch is typically that of viscoelastic materials; the larger pores (>5 microm) change, while the small pores stay constant in number and size. The median pore diameter in tablets compressed from the mixtures is higher than the median pore diameter in tablets compressed from the pure materials. This paper shows that the formation of large pores was the result of the extra porosity expansion of tablets compressed from binary mixtures of sodium chloride and pregelatinised starch.
authors.affiliation: Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. B.van.Veen@farm.rug.nl
authors.forename: B
authors.initials: B
authors.lastname: van Veen
authors.forename: K
authors.initials: K
authors.lastname: van der Voort Maarschalk
authors.forename: G K
authors.initials: GK
authors.lastname: Bolhuis
authors.forename: M R
authors.initials: MR
authors.lastname: Visser
authors.forename: K
authors.initials: K
authors.lastname: Zuurman
authors.forename: H W
authors.initials: HW
authors.lastname: Frijlink
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004339:Drug Compounding / Q000379:methods; D004548:Elasticity; D006358:Hot Temperature; D010316:Particle Size; D016062:Porosity; D011312:Pressure; D012965:Sodium Chloride / Q000737:chemistry*; D013213:Starch / Q000737:chemistry*; D013314:Stress, Mechanical; D013607:Tablets / Q000737:chemistry*; D013997:Time Factors
chemical_list: D013607:Tablets; D012965:Sodium Chloride; D013213:Starch