title: [Clinical observation of splenectomy on chronic idiopathic thrombocytopenic purpura in 63 patients].
abstract: OBJECTIVE
  To investigate the effectiveness of splenectomy in patients with idiopathic thrombocytopenic purpura who failed to respond to conservative management.
  
  
  METHODS
  Sixty-three patients were treated with splenectomy and followed up for 2 months to 16 years (average 4.7 years).
  
  
  RESULTS
  The patients had symptoms of bleeding and their platelet count on average was 24 x 10(9)/L. The first, 3rd, 5th and 7th day after operation, the average platelet count was 110 x 10(9)/L, 202 x 10(9)/L, 251 x 10(9)/L and 246 x 10(9)/L. Their platelet recovered to normal during a week in 51 cases (80.9%). The total effective rate was 86.9% after follow-up for 2 months. The recurrence rate was 17.9% in 39 cases after follow-up for longtime.
  
  
  CONCLUSIONS
  The curative effect of splenectomy is better in children than in adults. In patients with increased platelet have a favourable prognosis. Splenectomy is safe and effective in the treatment of idiopathic thrombocytopenic purpura.
authors.affiliation: Department of Surgery, People's Hospital, Beijing Medical University, Beijing 100044.
authors.forename: J
authors.initials: J
authors.lastname: Zhu
authors.forename: X
authors.initials: X
authors.lastname: Leng
authors.forename: N
authors.initials: N
authors.lastname: Dong
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Huang
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.forename: R
authors.initials: R
authors.lastname: Du
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000601:surgery*; D013156:Splenectomy; D016896:Treatment Outcome