Synthesis of some new triazoles as potential antifungal agents.
The rise in the incidence of fungal infections over the past two decades, particularly those caused by opportunistic pathogens in immune-compromised patients, has strengthened the need for new antifungal drugs. New triazole derivatives were synthesized and evaluated for their in-vitro antifungal activities against three species of fungi. Most of the prepared compounds showed good antifungal activity. Three compounds exhibited pronounced activity against Cryptococcus neoformans with MIC less than 12.5 g/ml.
Fahmy
H T
HT
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000935:Antifungal Agents; D014230:Triazoles