title: Intracortical inhibition is reduced in a patient with a lesion in the posterolateral thalamus.
abstract: We describe a patient who developed a complex movement disorder following an ischemic lesion in the right posterolateral thalamus. Transcranial magnetic stimulation showed a shortening of the cortical silent period and deficient cortico-cortical inhibition using paired magnetic pulses on the affected side, indicating reduced effectiveness of intracortical inhibitory mechanisms.
authors.affiliation: Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
authors.forename: Alexander
authors.initials: A
authors.lastname: Münchau
authors.forename: Michael
authors.initials: M
authors.lastname: Orth
authors.forename: John C
authors.initials: JC
authors.lastname: Rothwell
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Lazzaro
authors.forename: Antonio
authors.initials: A
authors.lastname: Oliviero
authors.forename: Paolo
authors.initials: P
authors.lastname: Profice
authors.forename: Pietro
authors.initials: P
authors.lastname: Tonali
authors.forename: Peter P
authors.initials: PP
authors.lastname: Pramstaller
authors.forename: Kailash P
authors.initials: KP
authors.lastname: Bhatia
mesh_terms: D000328:Adult; D055590:Electromagnetic Phenomena / Q000379:methods*; D004576:Electromyography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009069:Movement Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D009433:Neural Inhibition / Q000502:physiology*; D020656:Posterior Thalamic Nuclei / Q000473:pathology*; D014743:Videotape Recording