title: High serum luteinizing hormone and testosterone concentrations do not predict pregnancy outcome in women with recurrent miscarriage.
abstract: OBJECTIVE
  To investigate the relationship between Day 8 serum luteinizing hormone (LH) and testosterone (T) concentrations, and body mass index (BMI) with pregnancy outcome in women with recurrent miscarriage.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  National recurrent miscarriage clinic.
  
  
  METHODS
  Three hundred forty-four women (median age 32 years; range 18-44) with a history of recurrent first trimester miscarriage (median 4; 3-14; <12 weeks gestation) who conceived spontaneously and who received no pharmacological treatment during pregnancy were studied. All women were antiphospholipid antibody negative and had a normal peripheral karyotype as did their partners.
  
  
  METHODS
  Outcome of untreated pregnancies.
  
  
  METHODS
  Day 8 serum LH and T concentrations and BMI were correlated with pregnancy outcome.
  
  
  RESULTS
  One hundred and ninety-two (55.8%) women had a live birth and 152 (44.2%) women miscarried. Polycystic ovarian morphology was diagnosed in 174 women (50.6%). There was no significant relationship between follicular phase LH concentrations and pregnancy outcome. Pregnancy outcome was similar in women with normal and high serum T concentrations. BMI value was not significantly different between women who had a live birth and those who miscarried.
  
  
  CONCLUSIONS
  The analysis of this large cohort of women with recurrent miscarriage demonstrates that prepregnancy Day 8 serum LH and T concentrations, and BMI do not have a statistically significant relationship with pregnancy outcome.
authors.affiliation: Department of Reproductive Science and Medicine, Imperial College School of Medicine, St Mary's Hospital, Praed Street, London W2 1PG, United Kingdom.
authors.forename: Luciano G
authors.initials: LG
authors.lastname: Nardo
authors.forename: Raj
authors.initials: R
authors.lastname: Rai
authors.forename: May
authors.initials: M
authors.lastname: Backos
authors.forename: Safaa
authors.initials: S
authors.lastname: El-Gaddal
authors.forename: Lesley
authors.initials: L
authors.lastname: Regan
mesh_terms: D000026:Abortion, Habitual / Q000097:blood*; D000293:Adolescent; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D013739:Testosterone / Q000097:blood*
chemical_list: D017153:Antibodies, Anticardiolipin; D016682:Lupus Coagulation Inhibitor; D013739:Testosterone; D007986:Luteinizing Hormone