[Somatostatin and growth hormone promote spontaneous closure of enterocutaneous fistula].
OBJECTIVE
To find out the method for promoting spontaneous heal of enterocutaneous fistula.


METHODS
Experimentally, we investigated the effect of rhGH on wound granulation and intestinal mucosa. Clinically, combined somatostatin and rhGH was compared with somatostatin in the treatment of enteric fistula.


RESULTS
Animal studies demonstrated that rhGH was effective to increase the content of hydroxyproline and amount of fibroblast cell in wound granulation. In clinical trial, the spontaneous cure rate was significantly higher in patients treated with combined rhGH and somatostatin than in those treated with somatostatin alone (96.5% vs 68.4%, P < 0.01).


CONCLUSIONS
Combined rhGH and somatostatin is a new therapeutic method for the treatment of enteric fistula. It may promote the spontaneous cure of enteric fistula.
Li
J
J
Institute of General Surgery, Nanjing General Hospital, People's Liberation Army, Nanjing 210002, Chian.
Ren
J
J
Wang
X
X
Gu
J
J
Jiang
J
J
D000328:Adult; D000368:Aged; D000818:Animals; D002455:Cell Division; D004359:Drug Therapy, Combination; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects*; D005260:Female; D006097:Granulation Tissue / Q000166:cytology / Q000187:drug effects*; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007412:Intestinal Fistula / Q000188:drug therapy*; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000627:therapeutic use*; D014945:Wound Healing
D013004:Somatostatin; D013006:Growth Hormone