No post-genetics era in human disease research.
In the 1980s, linkage emerged as a route to discovering genetic defects, spurring the rise of genomics and making gene-based approaches available to previously phenotype-orientated researchers. In the post-genomics era, genetics is fundamental to understanding disease at all stages of the pathogenic process.
Gusella
James
J
Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. gusella@helix.mgh.harvard.edu
MacDonald
Marcy
M
D000818:Animals; D004195:Disease Models, Animal; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005826:Genetics, Medical; D005838:Genotype; D006801:Humans; D010641:Phenotype; D012106:Research