New and antifungal xanthones from Calophyllum caledonicum.
Two new xanthones, namely caledonixanthones E (1) and F (2), were isolated from the stem bark of Calophyllum caledonicum (Guttiferae). The structural elucidation of these compounds was mainly established on the basis of 1D, 2D NMR and HRMS spectroscopic analysis. Among the isolated compounds, eight other known xanthones were also identified in the course of this phytochemical study. In addition to this report, a preliminary evaluation of the antifungal properties of these polyphenolic compounds against Aspergillus fumigatus and Candida albicans is presented.
Morel
Cécile
C
SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la santé, 16, Bd Daviers, Angers, France.
Séraphin
Denis
D
Teyrouz
Agnès
A
Larcher
Gérald
G
Bouchara
Jean-Philippe
JP
Litaudon
Marc
M
Richomme
Pascal
P
Bruneton
Jean
J
D000935:Antifungal Agents / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D029759:Calophyllum; D002176:Candida albicans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D044004:Xanthones
D000935:Antifungal Agents; D010936:Plant Extracts; D014966:Xanthenes; D044004:Xanthones; C452872:caledonixanthone E; C452871:caledonixanthone F