title: Psychological mediation of a type of oxidative DNA damage, 8-hydroxydeoxyguanosine, in peripheral blood leukocytes of non-smoking and non-drinking workers.
abstract: BACKGROUND
  The present study investigates whether the formation of 8-hydroxydeoxyguanosine (8-OH-dG), a known oxidative DNA damage relevant to carcinogenicity, can be associated with psychological factors, in order to clarify the possible stress-cancer linkage from a genetic viewpoint.
  
  
  METHODS
  We performed a cross-sectional study in which we examined the relationships of the levels of 8-OH-dG in peripheral blood leukocytes to various psychological factors, including the Profile of Mood States (POMS) and the Center for Epidemiologic Studies Depression Scale (CES-D) in 38 non-smoking and non-drinking workers (19 males and 19 females).
  
  
  RESULTS
  The levels of 8-OH-dG in male subjects were negatively correlated with the Tension-Anxiety scores of the POMS. In contrast, the levels of 8-OH-dG in female subjects were positively correlated with the Depression-Rejection scores of the POMS and the CES-D scores, and negatively associated with the Vigor scores of the POMS, respectively. Male subjects who had self-blame coping strategy displayed significantly high levels of 8-OH-dG. Moreover, the worse the subjective closeness to parents in childhood, the higher the levels of 8-OH-dG became in male subjects. The levels of 8-OH-dG increased reliably in subjects who had experienced the loss of a close family member within 3 years, when compared with non-bereaved subjects.
  
  
  CONCLUSIONS
  Psychological distress may be associated with cancer risk, although sex difference influences them. Inadequate coping styles, possibly resulting from a poor interpersonal relationship with parents since childhood, and experience of a relatively recent loss of a close family member also appear to influence the pathogenesis of cancer.
authors.affiliation: Department of Mental Health, Institute of Industrial Ecological Sciences, Kitakyushu, Japan. irie@aichi-med-u.ac.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Irie
authors.forename: Shinya
authors.initials: S
authors.lastname: Asami
authors.forename: Shoji
authors.initials: S
authors.lastname: Nagata
authors.forename: Masakazu
authors.initials: M
authors.lastname: Miyata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kasai
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000223:Adaptation, Psychological; D000328:Adult; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000097:blood*; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D007962:Leukocytes; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology* / Q000523:psychology*; D018384:Oxidative Stress; D012737:Sex Factors; D012944:Social Support; D013315:Stress, Psychological
chemical_list: D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine