Signaling survival: how axons rescue their glia.
The trophic theory of cell survival hypothesizes that cell number is regulated by survival signals generated by other cells. Work published in this issue of Developmental Cell confirms that neurons can provide trophic support for glia in Drosophila, and fills in important molecular details of this interaction.
White
Kristin
K
Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
D000818:Animals; D001369:Axons / Q000502:physiology*; D002470:Cell Survival; D004330:Drosophila / Q000166:cytology* / Q000196:embryology* / Q000502:physiology; D029721:Drosophila Proteins; D004815:Epidermal Growth Factor; D066246:ErbB Receptors / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D008954:Models, Biological; D009457:Neuroglia / Q000166:cytology* / Q000378:metabolism; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism
D029721:Drosophila Proteins; D008565:Membrane Proteins; C076026:spi protein, Drosophila; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D020928:Mitogen-Activated Protein Kinases; D018631:ras Proteins