In vitro susceptibility of Mycobacterium tuberculosis to fusidic acid.
The aim of this study was to determine the in vitro susceptibility of 170 clinical isolates of Mycobacterium tuberculosis to fusidic acid using a proportion dilution method. Nineteen isolates were resistant to at least one first-line anti-tuberculosis drug. A total of 1.8% of the isolates were resistant to fusidic acid. Fusidic acid should be evaluated clinically as a potential supplementary drug for the treatment of infections due to multidrug-resistant strains of M. tuberculosis.
Cicek-Saydam
C
C
Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, 35100 Turkey. candanc2001@yahoo.com
Cavusoglu
C
C
Burhanoglu
D
D
Hilmioglu
S
S
Ozkalay
N
N
Bilgic
A
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial; D005672:Fusidic Acid / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D005672:Fusidic Acid