title: [Somatostatin and growth hormone promote spontaneous closure of enterocutaneous fistula].
abstract: OBJECTIVE
  To find out the method for promoting spontaneous heal of enterocutaneous fistula.
  
  
  METHODS
  Experimentally, we investigated the effect of rhGH on wound granulation and intestinal mucosa. Clinically, combined somatostatin and rhGH was compared with somatostatin in the treatment of enteric fistula.
  
  
  RESULTS
  Animal studies demonstrated that rhGH was effective to increase the content of hydroxyproline and amount of fibroblast cell in wound granulation. In clinical trial, the spontaneous cure rate was significantly higher in patients treated with combined rhGH and somatostatin than in those treated with somatostatin alone (96.5% vs 68.4%, P < 0.01).
  
  
  CONCLUSIONS
  Combined rhGH and somatostatin is a new therapeutic method for the treatment of enteric fistula. It may promote the spontaneous cure of enteric fistula.
authors.affiliation: Institute of General Surgery, Nanjing General Hospital, People's Liberation Army, Nanjing 210002, Chian.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Ren
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Gu
authors.forename: J
authors.initials: J
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002455:Cell Division; D004359:Drug Therapy, Combination; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects*; D005260:Female; D006097:Granulation Tissue / Q000166:cytology / Q000187:drug effects*; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007412:Intestinal Fistula / Q000188:drug therapy*; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000627:therapeutic use*; D014945:Wound Healing
chemical_list: D013004:Somatostatin; D013006:Growth Hormone