The role of NPY in the mediation of orexin-induced hypothermia.
The mediation of orexin-A-induced hypothermia was investigated. Different doses of orexin-A (140-560 pmol) were administered intracerebroventricularly (i.c.v.) to adult male rats, and the colon temperature was used as an index of the thermoregulatory action. Orexin-A decreased both the basal colon temperature and the lipopolysaccharide-induced fever and exhibited a bell-shaped dose-response curve. I.c.v. pretreatment with neuropeptide Y (NPY) antiserum 24 h before orexin administration significantly decreased the hypothermic effect of orexin-A. These data strengthen the hypothesis that this appetite-regulating peptide might also play a role in thermoregulation, and its hypothermic effect seems to be mediated at least partially by NPY.
Jászberényi
Miklós
M
Department of Pathophysiology, Albert Szent-Györgyi Medical and Pharmaceutical Centre, University of Szeged, MTA-SZTE Neurohumoral Research Group, PO Box 427, H-6701, Szeged, Hungary.
Bujdosó
Erika
E
Kiss
Edina
E
Pataki
Imre
I
Telegdy
Gyula
G
D000818:Animals; D001831:Body Temperature / Q000187:drug effects* / Q000502:physiology; D001833:Body Temperature Regulation / Q000502:physiology*; D002352:Carrier Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D003106:Colon / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy; D007035:Hypothermia / Q000139:chemically induced / Q000503:physiopathology*; D007276:Injections, Intraventricular / Q000379:methods; D047908:Intracellular Signaling Peptides and Proteins; D008070:Lipopolysaccharides; D008297:Male; D009478:Neuropeptide Y / Q000502:physiology*; D009479:Neuropeptides / Q000494:pharmacology* / Q000627:therapeutic use; D000068797:Orexins; D051381:Rats; D017208:Rats, Wistar
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008070:Lipopolysaccharides; D009478:Neuropeptide Y; D009479:Neuropeptides; D000068797:Orexins