Selenium-enriched broccoli decreases intestinal tumorigenesis in multiple intestinal neoplasia mice.
Multiple intestinal neoplasia (Min) mice are a good model for the investigation of the effects of dietary alterations in a genetic model for intestinal cancer. Previous studies have shown that selenium-enriched broccoli is protective against chemically induced colon cancer susceptibility. This study investigated whether selenium-enriched broccoli would be protective against intestinal cancer susceptibility in Min mice. Five-week-old heterozygotic male Min mice were fed an AIN-93-based diet containing either low-selenium broccoli or an equivalent amount of high-selenium broccoli for 10 wk. Mice fed the selenium-enriched broccoli had fewer (P < 0.02) small intestinal (46.4 +/- 3.7 vs. 65.6 +/- 6.1) and large intestinal (0.43 +/- 0.17 vs. 1.93 +/- 0.27) tumors than those fed an equivalent amount of unenriched broccoli. Min mice fed the selenium-enriched broccoli had small but significant (P < 0.0001) increases in plasma and liver selenium concentrations and red blood cell glutathione peroxidase activity. These results extend previous observations that selenium-enriched broccoli is protective against chemically induced mammary and colon cancer in rats.
Davis
Cindy D
CD
U. S. Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202-9034, USA. cdavis@gfhnrc.ars.usda.gov
Zeng
Huawei
H
Finley
John W
JW
D000818:Animals; D001937:Brassica / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D007414:Intestinal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012643:Selenium / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
D005979:Glutathione Peroxidase; D012643:Selenium