title: Effects of dimecron on developing chick embryo: malformations and other histopathological changes.
abstract: The effect of dimecron, an organophosphorus insecticide, on developmental alterations and histopathological damage was determined in the developing chick embryo. The insecticide was administered at two different doses (25 microg and 35 microg) into the egg yolk through a pore into the equatorial region at day 0 of incubation. Significant abnormalities in relation to organogenesis and overall retardation in growth were noted in the insecticide-treated embryos. Histopathological study of the treated whole embryo showed abnormal features in the formation of different vital organs. The liver and kidney were severely affected by the pesticide at both doses. Based upon these findings it may be concluded that dimecron does play a role in producing embryotoxicity at different stages of embryogenesis.
authors.affiliation: Department of Zoology, University of Kalyani, Kalyani, India. sahu@klyuniv.ernet.in
authors.forename: C R
authors.initials: CR
authors.lastname: Sahu
authors.forename: S
authors.initials: S
authors.lastname: Ghatak
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000196:embryology / Q000662:veterinary; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology; D002642:Chick Embryo / Q000187:drug effects* / Q000254:growth & development; D005123:Eye / Q000187:drug effects / Q000196:embryology; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000196:embryology; D008099:Liver / Q000187:drug effects / Q000196:embryology; D009672:Notochord / Q000187:drug effects / Q000196:embryology; D009929:Organ Size / Q000187:drug effects; D010707:Phosphamidon / Q000008:administration & dosage / Q000633:toxicity*; D013116:Spinal Cord / Q000187:drug effects / Q000196:embryology
chemical_list: D007306:Insecticides; D010707:Phosphamidon