Case report. Disseminated infection of Blastoschizomyces capitatus in a patient with acute myelocytic leukaemia.
Blastoschizomyces capitatus infection in a 48-year-old man with acute myelocytic leukaemia is reported. A multiorgan involvement and fulminant course of the fungal infection resulted in the patient's death despite fluconazole prophylaxis, therapy with amphotericin B and administration of granulocyte colony-stimulating factor. Predisposing factors to the infection, clinical relevance of surveillance strains and in vitro antifungal susceptibility testing are discussed.
Buchta
V
V
Zák
P
P
Kohout
A
A
Otcenásek
M
M
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D017809:Fatal Outcome; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D003904:Mitosporic Fungi / Q000187:drug effects / Q000302:isolation & purification*; D009102:Multiple Organ Failure / Q000150:complications; D009181:Mycoses / Q000188:drug therapy / Q000209:etiology*
D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole