Chymase inhibitor suppresses adhesion formation in a hamster experimental model.
To clarify the role of chymase produced by mast cells in adhesion formation, we investigated the preventive effect of a specific chymase inhibitor, Suc-Val-Pro-Phe(p) (OPh)2, on adhesion formation in a hamster experimental model. Hamsters underwent resection of the right uterine body and then 10 microM Suc-Val-Pro-Phe(p) (OPh)2 or placebo was injected into the abdomen. Two weeks after the operation, the scores for adhesion formation in the chymase inhibitor-treated group were significantly lower than that in the placebo-treated group (placebo-treated group, 3.60+/-0.22; chymase inhibitor-treated group, 2.10+/-0.22; P<0.01). This specific chymase inhibitor, Suc-Val-Pro-Phe(p) (OPh)2, significantly suppressed the scores for adhesion formation in a hamster experimental model. Thus, chymase may play an important role in the adhesion formation.
Okamoto
Yukiko
Y
Department of Pharmacology, Osaka Medical College, Osaka 589-8686, Takatsuki City, Japan.
Takai
Shinji
S
Miyazaki
Mizuo
M
D000818:Animals; D053818:Chymases; D006224:Cricetinae; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D008407:Mast Cells / Q000187:drug effects* / Q000502:physiology; D009842:Oligopeptides / Q000494:pharmacology*; D012697:Serine Endopeptidases / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology; D000267:Tissue Adhesions / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*
D004791:Enzyme Inhibitors; D009842:Oligopeptides; D015842:Serine Proteinase Inhibitors; C102024:succinyl-valyl-prolyl-phenylalanyl-diphenylphosphonate; D012697:Serine Endopeptidases; D053818:Chymases