title: From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch.
abstract: The presence of 10-13 M of chiral clusters of aromatic amino acids addresses aggregation of opposite-charged achiral porphyrin towards the formation of smart chiral assemblies. The latter supramolecular complexes are able to self-propagate and transfer their chiral information with a 100% yield. The chiral bias occurs through a correlated sequence of induction, memory, and amplification of chirality that strongly recalls possible prebiotic scenarios.
authors.affiliation: Istituto per lo Studio delle Sostanze Naturali di Interesse Alimentare e Chimico Farmaceutico, CNR, Sezione di Catania, Catania, Italy.
authors.forename: Rosaria
authors.initials: R
authors.lastname: Lauceri
authors.forename: Antonio
authors.initials: A
authors.lastname: Raudino
authors.forename: Luigi Monsù
authors.initials: LM
authors.lastname: Scolaro
authors.forename: Norberto
authors.initials: N
authors.lastname: Micali
authors.forename: Roberto
authors.initials: R
authors.lastname: Purrello
mesh_terms: D002942:Circular Dichroism; D003300:Copper / Q000737:chemistry*; D008665:Metalloporphyrins / Q000737:chemistry*; D010649:Phenylalanine / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D013237:Stereoisomerism; D013698:Templates, Genetic
chemical_list: C429764:5,10,15-tris(4-sulfonatophenyl)-20-phenylporphryin; D008665:Metalloporphyrins; D011166:Porphyrins; C078184:copper tetra(4-N-methylpyridyl)porphine; D010649:Phenylalanine; D003300:Copper