Pyloricidins, novel anti-helicobacterpylori antibiotics produced by Bacillus sp. I. Taxonomy, fermentation and biological activity.
Novel anti-Helicobacter pylori antibiotics, pyloricidins A, A1, A2, B, C and D, were discovered in the culture broth of two bacilli strains. Pyloricidins selectively inhibited the growth of H. pylori. Pyloricidin B was efficacious in the treatment of gastric infection caused by H. pylori in Mongolian gerbils and may be promising for cure of H. pylori infection as a single agent.
Nakao
M
M
Pharmacology Research laboratories II, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan.
Miyagaw
K
K
Nakano
Y
Y
Sakane
T
T
Tada
M
M
Nishimura
O
O
Fujino
M
M
D000658:Amoxicillin / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001407:Bacillus / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D001681:Biological Assay; D017291:Clarithromycin / Q000494:pharmacology; D005285:Fermentation; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010455:Peptides
D000900:Anti-Bacterial Agents; D010455:Peptides; D008795:Metronidazole; D000658:Amoxicillin; D017291:Clarithromycin