Recombinant follicle-stimulating hormone stimulates ovarian androgen synthesis in down-regulated ovulatory women.
In order to study androgen secretion during controlled ovarian hyperstimulation for in-vitro fertilization-embryo transfer, an open randomized study comparing the response to recombinant or urinary follicle-stimulating hormone (FSH) in down-regulated cycles was performed. During FSH administration significant increases in testosterone, androstenedione and dehydroepiandrosterone sulfate (DHEAS) levels were observed. During the same period a slight decrease in luteinizing hormone (LH) levels was seen. At all times during the stimulation period a significant correlation between estradiol and testosterone or androstenedione levels was observed. We conclude that FSH, through granulosa derived paracrine factors, initiates thecal androgen synthesis and secretion.
Tanbo
T
T
Department of Obstetrics and Gynecology, National Hospital, University of Oslo, Norway.
Dale
P O
PO
Abyholm
T
T
D000728:Androgens / Q000096:biosynthesis*; D000735:Androstenedione / Q000096:biosynthesis / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004624:Embryo Transfer; D004958:Estradiol / Q000096:biosynthesis; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism*; D010060:Ovulation; D011994:Recombinant Proteins / Q000494:pharmacology; D013739:Testosterone / Q000096:biosynthesis / Q000097:blood
D000728:Androgens; D011994:Recombinant Proteins; D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone