Does vitamin C intake slow the progression of gastric cancer in Helicobacter pylori-infected populations?
Vitamin C's role in the prevention of disease and malignancy has been studied over the last several decades. Vitamin C intake has been shown to have an inverse relationship with gastric cancer. Recent follow-up studies on high-risk populations suggest that ascorbic acid, the reduced form of vitamin C, protects against gastric cancer, for which H. pylori is a significant risk factor. In populations infected with H. pylori, there is a reduction in gastric juice ascorbic acid concentration. This article reviews the risk factors for gastric cancer and the role of vitamin C in prevention of the disease.
Feiz
Hamid Reza
HR
Department of Gastroenterology, Loyola University of Chicago, Maywood, IL 60153, USA.
Mobarhan
Sohrab
S
D001205:Ascorbic Acid / Q000627:therapeutic use*; D018450:Disease Progression; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D005756:Gastritis / Q000150:complications* / Q000382:microbiology / Q000517:prevention & control; D016481:Helicobacter Infections / Q000150:complications* / Q000517:prevention & control; D016480:Helicobacter pylori; D006801:Humans; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology / Q000517:prevention & control*
D016166:Free Radical Scavengers; D001205:Ascorbic Acid