title: New anti-malarial compounds from database searching.
abstract: In a serendipitous result, pharmacophores generated for the database searching for new non-nucleoside inhibitors of the HIV-1 reverse transcriptase enzyme unearthed 12 new lead compounds which were active against the Plasmodium falciparum strain of malaria.
authors.affiliation: School of Biological and Chemical Sciences, University of Newcastle, 2308, Callaghan, NSW, Australia.
authors.forename: Renate
authors.initials: R
authors.lastname: Griffith
authors.forename: Rachada
authors.initials: R
authors.lastname: Chanphen
authors.forename: Scott P
authors.initials: SP
authors.lastname: Leach
authors.forename: Paul A
authors.initials: PA
authors.lastname: Keller
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D016208:Databases, Factual; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors; D006571:Heterocyclic Compounds; D006801:Humans; D020128:Inhibitory Concentration 50; D010963:Plasmodium falciparum / Q000187:drug effects*; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D006571:Heterocyclic Compounds; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase