title: Right ventricular performance during left ventricular unloading conditions: the contribution of the right ventricular free wall.
abstract: OBJECTIVE
  Right ventricular (RV) dysfunction is a significant complication following implantation of left ventricular assist device (LVAD). However, RV performance after LVAD implantation remains unclear. We have studied the effects of preload and afterload on RV performance under left ventricular (LV) unloading.
  
  
  METHODS
  Six adult mongrel dogs were subjected to cardiopulmonary bypass. RV preload and afterload were independently regulated. Dynamic pressure-length analysis of RV free walls was performed using micromanometer catheter and sonomicrometric dimension transducers. Global RV systolic function was evaluated by the relationship between stroke volume vs. end-diastolic length (EDL) or end-diastolic pressure (EDP). We also examined the afterload dependency of RV performance at constant stroke volume.
  
  
  RESULTS
  Stroke volume vs. EDP and stroke volume vs. EDL demonstrated a linear relationship (r(2) = 0.849 +/- 0.147 and 0.776 +/- 0.121, respectively). At constant stroke volume, RV systolic peak pressure vs. EDL or EDP were shown to have a linear relationship (r(2) = 0.906 +/- 0.050 vs. 0.909 +/- 0.047, respectively).
  
  
  CONCLUSIONS
  The Frank-Starling relationship for RV performance was shown in this animal model. Without interventricular interaction, RV preload is dependent on RV afterload.
authors.affiliation: Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: T
authors.initials: T
authors.lastname: Omoto
authors.forename: H
authors.initials: H
authors.lastname: Tanabe
authors.forename: P J
authors.initials: PJ
authors.lastname: LaRia
authors.forename: J
authors.initials: J
authors.lastname: Guererro
authors.forename: G J
authors.initials: GJ
authors.lastname: Vlahakes
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002315:Cardiopulmonary Bypass; D004285:Dogs; D006353:Heart-Assist Devices / Q000009:adverse effects*; D013318:Stroke Volume / Q000502:physiology; D018497:Ventricular Dysfunction, Right / Q000503:physiopathology*; D016278:Ventricular Function, Right / Q000502:physiology*; D017725:Ventricular Pressure / Q000502:physiology