title: Effect of topical betaxolol on the acute rise of aqueous flare induced by highly selective agonists for prostaglandin E2 receptor subtypes in pigmented rabbits.
abstract: OBJECTIVE
  To evaluate the role of topical betaxolol on experimental ocular inflammation in rabbits.
  
  
  METHODS
  Transcorneal diffusion of highly selective agonists for prostaglandin E2 receptor subtypes (EP), 25 microg/ml, with the use of a glass cylinder, was performed to produce aqueous flare elevation in pigmented rabbits. Betaxolol was topically administered before EP agonist application. Aqueous flare was measured with a laser flare cell meter.
  
  
  RESULTS
  Performing topical instillation of 0.5% betaxolol 4 times inhibited 52 +/- 9% of EP2-agonist (ONO-AE1-259-01)-induced aqueous flare elevation. The inhibition of flare elevation was dependent on the number of betaxolol instillations. Betaxolol did not suppress the elevation induced by an EP4 agonist (ONO-AE1-392).
  
  
  CONCLUSIONS
  Betaxolol inhibited EP2-agonist-induced aqueous flare elevation in pigmented rabbits.
authors.affiliation: Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan.
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Yanagisawa
authors.forename: Seiji
authors.initials: S
authors.lastname: Hayasaka
authors.forename: Xue-Yun
authors.initials: XY
authors.lastname: Zhang
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Hayasaka
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Nagaki
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kitagawa
mesh_terms: D000208:Acute Disease; D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D015784:Betaxolol / Q000008:administration & dosage / Q000627:therapeutic use*; D018916:Blood-Aqueous Barrier; D008297:Male; D011817:Rabbits; D018078:Receptors, Prostaglandin E / Q000819:agonists* / Q000378:metabolism; D058307:Receptors, Prostaglandin E, EP2 Subtype; D058309:Receptors, Prostaglandin E, EP4 Subtype; D014606:Uveitis, Anterior / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*
chemical_list: D000319:Adrenergic beta-Antagonists; D018078:Receptors, Prostaglandin E; D058307:Receptors, Prostaglandin E, EP2 Subtype; D058309:Receptors, Prostaglandin E, EP4 Subtype; D015784:Betaxolol