Successful pregnancy outcome in a lung transplant recipient with tacrolimus immunosuppression. A case report.
BACKGROUND
The use of tacrolimus (FK506, PROGRAF) in pregnant lung transplant recipients has been very rarely reported.


METHODS
A 32-year-old woman, gravida 1, para 0, had previously undergone a unilateral lung transplant secondary to pulmonary fibrosis. Four years later she spontaneously conceived. During pregnancy, she was maintained on an immunosuppressive regimen of tacrolimus and prednisone. Bi-weekly pulmonary function testing remained unchanged until 34 weeks' gestation. At that time, labor was induced due to concern for allograft rejection. A healthy, 2,208-g, female infant was born via an uncomplicated vaginal delivery. Postpartum transbronchial biopsy showed minimal acute cellular rejection.


CONCLUSIONS
Lung transplant recipients may achieve successful pregnancy outcomes with the use of tacrolimus.
Kruszka
Stephen J
SJ
Division of Maternal/Fetal Medicine, Department of Obstetrics and Gynecology, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708, USA.
Gherman
Robert B
RB
D000328:Adult; D005260:Female; D005865:Gestational Age; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D016040:Lung Transplantation / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control*; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk; D011379:Prognosis; D011658:Pulmonary Fibrosis / Q000601:surgery; D016559:Tacrolimus / Q000008:administration & dosage*; D014181:Transplantation Immunology
D007166:Immunosuppressive Agents; D016559:Tacrolimus