title: Antimicrobial susceptibilities of clinical isolates of Haemophilus influenzae and Moraxella catarrhalis collected during 1999-2000 from 13 countries.
abstract: OBJECTIVE
  To determine antimicrobial activity against Haemophilus influenzae and Moraxella catarrhalis.
  
  
  METHODS
  A central laboratory performed NCCLS susceptibility testing for all isolates and beta-lactamase and capsular serotype determinations for H. influenzae.
  
  
  RESULTS
  A total of 2712 H. influenzae and 1079 M. catarrhalis were collected. H. influenzae susceptibilities were >90% for amoxicillin/clavulanate, cefaclor, loracarbef, cefprozil, cefuroxime, ciprofloxacin, azithromycin and clarithromycin and were <80% for trimethoprim/sulfamethoxazole and ampicillin. 19.3% were beta-lactamase positive. The most common serotype was type-b (5.6%); 86.1% were nontypeable. M. catarrhalis had MIC90 within therapeutic range for all antimicrobials except ampicillin.
  
  
  CONCLUSIONS
  The conclusion of the study is that antimicrobials, except ampicillin and trimethoprim/sulfamethoxazole, remain good empiric choices against H. influenzae and M. catarrhalis.
authors.affiliation: Lilly Research Laboratories, Lilly Corporate Center, DC 6061, Indianapolis, IN 46285, USA. turnak_mark@lilly.com
authors.forename: M R
authors.initials: MR
authors.lastname: Turnak
authors.forename: S I
authors.initials: SI
authors.lastname: Bandak
authors.forename: S K
authors.initials: SK
authors.lastname: Bouchillon
authors.forename: B S
authors.initials: BS
authors.lastname: Allen
authors.forename: D J
authors.initials: DJ
authors.lastname: Hoban
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001208:Asia; D001315:Australia; D002648:Child; D002675:Child, Preschool; D004534:Egypt; D005060:Europe; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008800:Mexico; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D001936:Moraxella catarrhalis / Q000187:drug effects* / Q000302:isolation & purification; D065093:beta-Lactamase Inhibitors
chemical_list: D000900:Anti-Bacterial Agents; D065093:beta-Lactamase Inhibitors