ECM remodeling regulates angiogenesis: endothelial integrins look for new ligands.
The process of angiogenesis is a dynamic one. Vascular endothelial cells are changing at the same time the extracellular matrix is being remodeled. Stupack and Cheresh discuss how remodeling of the extracellular matrix (ECM) and changes in the endothelial cell protein production and integrin expression contribute to the complex process of new blood vessel growth from an existing vascular bed.
Stupack
Dwayne G
DG
Departments of Immunology and Vascular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. stupack@scripps.edu
Cheresh
David A
DA
D000818:Animals; D004730:Endothelium, Vascular / Q000378:metabolism / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008024:Ligands; D018919:Neovascularization, Physiologic / Q000502:physiology*
D016326:Extracellular Matrix Proteins; D016023:Integrins; D008024:Ligands