Anterior chamber infiltrates associated with systemic lymphoma: report of two cases and review of the literature.
OBJECTIVE
To describe the clinicopathologic features of two patients with systemic lymphoma who developed anterior chamber (AC) infiltrates of lymphoma cells.


METHODS
Two case reports and literature review.


METHODS
The clinical and pathologic findings in two patients with AC infiltrates secondary to systemic B-cell lymphoma are reviewed.


METHODS
Clinical observation and cytologic/flow cytometric examination of the infiltrate after AC aspiration.


RESULTS
One patient presented with uveal infiltration, an exudative retinal detachment and an AC infiltrate. Systemic evaluation revealed a follicular lymphoma involving several groups of lymph nodes. The second patient with a known history of abdominal lymphoma was found to have blurred vision, photophobia and an AC infiltrate. Flow cytometric analysis of the AC infiltrate in both patients showed phenotypes consistent with the patients' systemic lymphomas.


CONCLUSIONS
A pseudohypopyon in an adult may represent either the initial manifestation or a later complication of systemic lymphoma, similar to what has been reported in acute leukemia.
O'Keefe
J Stewart
JS
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Sippy
Brian D
BD
Martin
Daniel F
DF
Holden
Jeannine T
JT
Grossniklaus
Hans E
HE
D000008:Abdominal Neoplasms / Q000473:pathology; D000328:Adult; D000867:Anterior Chamber / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D003131:Combined Modality Therapy; D005134:Eye Neoplasms / Q000556:secondary*; D017809:Fatal Outcome; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D008207:Lymphatic Metastasis; D008224:Lymphoma, Follicular / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D008297:Male; D013492:Suppuration / Q000473:pathology
D014408:Biomarkers, Tumor