title: [A case of bladder tumor producing granulocyte-colony stimulation factor and parathyroid hormone-related protein].
abstract: A 68-year-old woman presented with urinary pain and frequency. Cystoscopy, intravenous pyelography and magnetic resonance imaging showed a huge bladder mass and hydronephrosis of the left kidney. Transurethral resection of bladder tumor (TUR-Bt) was done. Histopathological findings of TUR-biopsy was high grade transitional cell carcinoma. Post operatively, the laboratory examination showed marked leukocytosis with a maximum of 99,600/mm3 in the peripheral blood and a high level of granulocyte colony stimulating factor (G-CSF), 70 pg/ml in the serum (normal: less than 9.8 pg/ml). Serum calcium level increased gradually and parathyroid hormone-related protein (PTH-rP) revealed high, 8.4 pMol/l (normal: less than 0.6 pMol/l). The tumor cells were positive for G-CSF and PTH-rP immunohistochemical staining. She died of the disease 46 days after the operation. This is the third case of G-CSF and PTH-rP producing bladder tumor in the literature.
authors.affiliation: Department of Urology, Yokohama Minami Kyousai Hospital.
authors.forename: F
authors.initials: F
authors.lastname: Tsuchiya
authors.forename: I
authors.initials: I
authors.lastname: Ikeda
authors.forename: F
authors.initials: F
authors.lastname: Kanda
authors.forename: H
authors.initials: H
authors.lastname: Fukuoka
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000378:metabolism*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D010281:Parathyroid Hormone / Q000096:biosynthesis*; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments / Q000096:biosynthesis*; D011506:Proteins; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*
chemical_list: D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments; D011506:Proteins; C071784:parathyroid hormone-related protein (107-111); D016179:Granulocyte Colony-Stimulating Factor