title: [Investigation of factors affecting the development of COPD].
abstract: OBJECTIVE
  To investigate the factors which affect the development of COPD.
  
  
  METHODS
  88 patients with mPAP less than 20 mm Hg were followed up by 5 - 20 years. Pulmonary ventilation, blood gas analysis, ECG, pulmonary hemodynamic parameters and oxygen saturation at night were performed one time every 5 years.
  
  
  RESULTS
  The results showed that: 5 year, 10 year and 20 year's mortality is 6%, 25% and 43% respectively; MVV%, FEV(1)% and PaO(2) declined accompanied by the increase of PaCO(2); among 41 patients with mPAP 16 - 20 mm Hg, 20 patients' mPAP were more than 20 mm Hg and 15 patients died after 10 years' follow up. Among 16 patients with the declination of oxygen saturation, 8 patients' mPAP were more than 20 mm Hg and 6 patients died. 57 strains of infectious bacteria were found in 88 patients' sputum with 43 strains in the death group.
  
  
  CONCLUSIONS
  These results demonstrated that COPD is a kind of chronic diseases with high death rate; infection, decline of oxygen saturation at night and mPAP more than 16 mm Hg were high risk factors in COPD.
authors.affiliation: Respiratory Department, General Hospital of Guangzhou Unit, PLA, Guangzhou 510010.
authors.forename: X
authors.initials: X
authors.lastname: Zou
authors.forename: D
authors.initials: D
authors.lastname: Xin
authors.forename: L
authors.initials: L
authors.lastname: Chi
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: W
authors.initials: W
authors.lastname: Qin
authors.forename: R
authors.initials: R
authors.lastname: Weng
mesh_terms: D000328:Adult; D000368:Aged; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000860:Hypoxia / Q000150:complications; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011651:Pulmonary Artery / Q000503:physiopathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology* / Q000503:physiopathology; D012141:Respiratory Tract Infections / Q000150:complications; D012907:Smoking / Q000009:adverse effects
chemical_list: D010100:Oxygen