title: A new coumarin from Murraya paniculata.
abstract: A new natural product, 2'-O-ethylmurrangatin (1) was isolated along with two previously known compounds murranganone (2) and paniculatin (3) from the leaves of Murraya paniculata. The structure of compound 1 was elucidated with the help of spectroscopic studies and by chemical reactions. Compounds 2 and 3 have been found to be cholinesterase inhibitors.
authors.affiliation: International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan. hejric@digicom.net.pk
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.lastname: Azizuddin
authors.forename: Asaad
authors.initials: A
authors.lastname: Khalid
authors.forename: Shaikh Ziauddin
authors.initials: SZ
authors.lastname: Sultani
authors.lastname: Atta-ur-Rahman
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D027821:Rutaceae
chemical_list: C452986:2'-O-ethylmurrangatin; D002800:Cholinesterase Inhibitors; D003374:Coumarins; D010936:Plant Extracts; C452985:murranganone; C452987:paniculatin; C030123:coumarin; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase