Identification of a new circulating recombinant form of HIV type 1, CRF11-cpx, involving subtypes A, G, J, and CRF01-AE, in Central Africa.
In this study, we characterized three full-length genome sequences with a similar mosaic structure from epidemiologically unlinked individuals from Cameroon (97CM-MP818) and the Central African Republic (99CF-MP1298 and 99CF-MP1307). Phylogenetic and recombinant analysis confirmed that the three strains had a similar complex recombinant genome, which we can designate now as CRF11-cpx. This new CRF was composed of successive fragments of subtype A, G, J, and CRF01-AE. The previously reported GR17 virus from a Greek patient infected in the Democratic Republic of Congo (DRC) has a similar structure and should be considered as the prototype strain of CRF11-cpx. This new CRF circulates in Cameroon, Central African Republic, Gabon, and DRC, although the exact prevalences remain to be determined.
Montavon
Celine
C
Laboratoire Retrovirus, UR36, IRD and University of Montpellier, Montpellier, France.
Vergne
Laurence
L
Bourgeois
Anke
A
Mpoudi-Ngole
Eitel
E
Malonga-Mouellet
Gabriel
G
Butel
Christelle
C
Toure-Kane
Coumba
C
Delaporte
Eric
E
Peeters
Martine
M
D001483:Base Sequence; D002163:Cameroon / Q000453:epidemiology; D002488:Central African Republic / Q000453:epidemiology; D004279:DNA, Viral; D015752:Genes, env; D015754:Genes, nef; D015751:Genes, pol; D016679:Genome, Viral; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic
D004279:DNA, Viral