Chronic lymphocytic leukemia with a novel der(8;15)(q10;q10) translocation.
A 71-year-old male was found to have chronic lymphocytic leukemia. Cytogenetic study of the leukemic lymphocytes shows a 46,XY,der(8;15)+15. The der(8;15) is a novel chromosomal abnormality in human malignancies. The resulting loss of 8p and trisomy 15q are both unusual chromosomal changes in chronic lymphocytic leukemia.
Wong
K F
KF
Department of Pathology, Queen Elizabeth Hospital, SAR, Hong Kong, China. kfwong@ha.org.hk
So
C C
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D000368:Aged; D002884:Chromosomes, Human, Pair 15; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic