Necrosis in leg ulcers. Probable role of fluocinolone acetonide.
Necrosis in chronic leg ulcers developed in all of the four patients who were treated topically with a fluocinolone acetonide-neomycin sulfate ointment. This was probably due to the vasoconstrictive properties of the steroid. A warning against the topical use of potent steroids in skin diseases with impaired circulation seems to be justified.
Bjornberg
A
A
Universitetet I Goteborg, Department of Dermatology, Sahlgrenska sjukhuset, Gothenburg, Sweden.
Hellgren
L
L
D000287:Administration, Topical; D000368:Aged; D005260:Female; D005446:Fluocinolone Acetonide / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy* / Q000473:pathology*; D008875:Middle Aged; D009336:Necrosis; D009355:Neomycin / Q000008:administration & dosage; D009824:Ointments
D009824:Ointments; D005446:Fluocinolone Acetonide; D009355:Neomycin