Anti-Yo antibody-positive cerebellar degeneration associated with endometrial carcinoma: case report and review of the literature.
Paraneoplastic cerebellar degeneration (PCD) is a rare, severely debilitating disease, often with a rapid onset and progression, which predate the diagnosis of malignancy. Despite characteristic features, diagnosis is commonly difficult and successful therapy, which relies on early instigation of treatment, is rare. Here we present a patient in whom anti-Yo antibody-positive PCD was associated with endometrial carcinoma and an extensive review of the literature outlining the clinical features, pathogenesis and treatment of PCD.
Brock
S
S
Wessex Cancer Centre, Southampton, UK.
Ellison
D
D
Frankel
J
J
Davis
C
C
Illidge
T
T
D000368:Aged; D001324:Autoantigens / Q000276:immunology*; D004268:DNA-Binding Proteins / Q000276:immunology*; D016889:Endometrial Neoplasms / Q000276:immunology / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009363:Neoplasm Proteins / Q000276:immunology*; D009419:Nerve Tissue Proteins; D020362:Paraneoplastic Cerebellar Degeneration / Q000276:immunology / Q000473:pathology*
D001324:Autoantigens; C063762:CDR1 protein, human; C095184:CDR2 protein, human; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins