Intermolecular copper-catalyzed carbon [bond] hydrogen bond activation via carbene insertion.
A series of catalysts of general formula TpXCu (TpX = homoscorpionate ligand) promote the insertion of :CHCO2Et (ethyl diazoacetate as the carbene source) into the C-H bonds of cycloalkanes and cyclic ethers in moderate to high yield. A correlation between the steric hindrance of these catalysts and the yield of the transformation has been observed.
Díaz-Requejo
M Mar
MM
Departamento de Química y Ciencia de Materiales, Universidad de Huelva, Carretera de Palos de la Frontera 21819-Huelva, Spain.
Belderraín
Tomás R
TR
Nicasio
M Carmen
MC
Trofimenko
Swiatoslaw
S
Pérez
Pedro J
PJ