[Histamine-1 and -2 receptors in hepatic tissues of cirrhotic patients with portal hypertension].
OBJECTIVE
To study histamine-1 and histamine-2 receptors in hepatic tissues of cirrhotic patients with portal hypertension.


METHODS
Light autoradiography was used.


RESULTS
The density of histamine-2 (H-2) receptors (cirrhotic patients/controls) in hepatocytes was 168.4 +/- 22.6/511.9 +/- 37.6 (P < 0.01), in hepatic vein 238.8 +/- 40.7/313.0 +/- 52.4 (P < 0.01), in hepatic artery 55.6 +/- 7.1/175.4 +/- 26.1 (P < 0.01), and in portal vein 52.0 +/- 5.4/166.4 +/- 17.7 (P < 0.01). The density of histamine-1 receptors in hepatocytes, hepatic vein, hepatic artery and portal vein was not statistically changed between cirrhotic patients and controls (P > 0.05).


CONCLUSIONS
The density of H-2 receptors in hepatic tissues of cirrhotic patients decreased significantly.
Zhang
Z
Z
Department of General Surgery, 252nd Hospital of People's Liberation Army, Baoding 071000.
Leng
X
X
Feng
H
H
Ma
F
F
Wang
B
B
D000328:Adult; D001345:Autoradiography; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism*; D008875:Middle Aged; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D011970:Receptors, Histamine H2 / Q000378:metabolism*
D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2