Genetic control of a mouse serum lipoprotein factor that inactivates murine leukemia viruses: evaluation of apolipoprotein F as a candidate.
Mice contain a serum factor capable of inactivating some subgroups of murine leukemia viruses. This leukemia virus-inactivating factor (LVIF) is distinct from immunoglobulin and complement; it has been associated with lipoprotein serum fractions and may be an apolipoprotein. The present study demonstrates that some Swiss-derived inbred strains are LVIF negative. Genetic crosses show this factor to be under control of a single gene that maps to distal chromosome 10 at or near the gene encoding a minor serum apolipoprotein, apolipoprotein F (ApoF). To evaluate this gene as a potential candidate for LVIF, the mouse ApoF gene was cloned and sequenced and its expression was assessed in LVIF-positive and -negative mice; no obvious differences were detected, suggesting that LVIF is under the control of a distinct linked gene.
Wu
Tiyun
T
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Building 4, Room 329, 4 Center Drive, Bethesda, MD 20892-0460, USA.
Lee
Chun G
CG
Buckler-White
Alicia
A
Kozak
Christine A
CA
D000595:Amino Acid Sequence; D000818:Animals; D000998:Antiviral Agents / Q000097:blood / Q000737:chemistry / Q000235:genetics*; D001053:Apolipoproteins / Q000097:blood / Q000737:chemistry / Q000235:genetics*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D020022:Genetic Predisposition to Disease; D006801:Humans; D009052:Leukemia Virus, Murine / Q000187:drug effects / Q000472:pathogenicity* / Q000502:physiology; D007942:Leukemia, Experimental / Q000235:genetics* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D012192:Retroviridae Infections / Q000235:genetics / Q000821:virology; D017422:Sequence Analysis, DNA; D014158:Transcription, Genetic; D014412:Tumor Virus Infections / Q000235:genetics / Q000821:virology
D000998:Antiviral Agents; D001053:Apolipoproteins; C036321:apolipoprotein F