Alpha-glucosidase inhibitory constituents from Cuscuta reflexa.
Two new compounds, 7'-(3',4'-dihydroxyphenyl)-N-[(4-methoxyphenyl)ethyl]propenamide (4), and 7'-(4'-hydroxy,3'-methoxyphenyl)-N-[(4-butylphenyl)ethyl]propenamide (5) have been isolated from Cuscuta reflexa along with five known compounds, 6,7-dimethoxy-2H-1-benzopyran-2-one (1), 3-(3,4-dihydroxyphenyl)-2-propen-1-ethanoate (2), 6,7,8-trimethoxy-2H-1-benzopyran-2-one (3), 3-(4-O-beta-D-glucopyranoside-3,5-dimethoxyphenyl)-2-propen-1-ol (6), 2-(3-hydroxy-4-methoxyphenyl)-3,5-dihydroxy-7-O-beta-D-glucopyranoside-4H-1-benzopyrane-4-one (7), reported for the first time from this species. Structures of these compounds were determined by spectral analysis. These compounds showed strong inhibitory activity against alpha-glucosidase.
Anis
Erum
E
International Center for Chemical Sciences, H.E.J Research Institute of Chemistry, University of Karachi, Pakistan.
Anis
Itrat
I
Ahmed
Saeed
S
Mustafa
Ghulam
G
Malik
Abdul
A
Afza
Nighat
N
Hai
Syed Muhammad Abdul
SM
Shahzad-ul-hussan
Syed
S
Choudhary
Muhammad Iqbal
MI
D000577:Amides / Q000302:isolation & purification*; D002850:Chromatography, Gel; D027722:Convolvulaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000302:isolation & purification*; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
C460621:7'-(3',4'-dihydroxyphenyl)-N-((4-methoxyphenyl)ethyl)propenamide; C460639:7'-(4'-hydroxy,3'-methoxyphenyl)-N-((4-butylphenyl)ethyl)propenamide; D000577:Amides; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts