title: Short-wavelength sensitivity deficits in patients with migraine.
abstract: OBJECTIVE
  To examine short-wavelength sensitivity in patients with migraine using short-wavelength automated perimetry (SWAP) and Stiles 2-color increment threshold procedures.
  
  
  METHODS
  Twenty-five subjects with migraine with (n = 11) and without (n = 14) aura and 20 age-matched headache-free subjects underwent testing. All subjects underwent standard automated perimetry (SAP) and SWAP (using a Humphrey field analyzer; 24-2 presentation pattern). In 2 migraine patients (one with and another without aura), the 2-color increment threshold procedure was used to determine whether sensitivity losses were specific to short-wavelength sensitivity pathways or a generalized loss to multiple pathways.
  
  
  RESULTS
  No statistically significant differences between migraine patients and controls were found for mean deviation (MD) or pattern-standard deviation (PSD) for SAP. However, for SWAP, MD and PSD were worse for the migraine group (P =.04). Twelve migraine patients had more than 4 locations with sensitivity worse than the 5% probability level (reference value). Increment threshold determinations in the 2 selected migraine patients indicated a selectively greater loss for short-wavelength sensitivity mechanisms.
  
  
  CONCLUSIONS
  Approximately 50% of subjects with migraine (with or without aura) demonstrate SWAP sensitivity losses, at times between migraine events. These findings, in conjunction with previous results for SAP and flicker perimetry, suggest that migraine patients should be excluded from normative databases of visual function, and warrant further investigations of the relationship between migraine and glaucoma.
authors.affiliation: Discoveries in Sight, Devers Eye Institute, Legacy Clinical Research and Technology Center, 1225 NE Second Ave, PO Box 3950, Portland, OR 97208-3950, USA.
authors.forename: Allison M
authors.initials: AM
authors.lastname: McKendrick
authors.forename: George A
authors.initials: GA
authors.lastname: Cioffi
authors.forename: Chris A
authors.initials: CA
authors.lastname: Johnson
mesh_terms: D000293:Adolescent; D000328:Adult; D003119:Color Perception Tests; D006801:Humans; D008881:Migraine Disorders / Q000150:complications*; D010468:Perceptual Disorders / Q000209:etiology / Q000503:physiopathology; D017949:Retinal Cone Photoreceptor Cells / Q000503:physiopathology; D012684:Sensory Thresholds; D014786:Vision Disorders / Q000209:etiology* / Q000503:physiopathology; D058609:Visual Field Tests; D014794:Visual Fields; D014795:Visual Pathways / Q000503:physiopathology; D014796:Visual Perception