title: ["High pouch output" syndrome. Role of mineralocorticoid diagnosis after restorative proctocolectomy].
abstract: The two-phase restorative proctocolectomy is the treatment of choice for surgical therapy of the familial adenomatous polyposis (FAP) and also for the ulcerative colitis (UC). Besides the well-known complications the entire removal of the colorectum leads to an impairment of fluid and electrolyte resorption.
  
  
  METHODS
  Over a time period of two years we observed 320 proctocolectomized patients with ileal pouch-anal anastomosis (IPAA). All patients with high pouch output but without organic malfunction were identified. The organic reasons were excluded with the help of pouchoscopy, radiography or MR imaging. We evaluated routine parameters, the kidney function, the electrolyte changes, the acid-base balance and the urine pH, as well as the hormonal changes of the suprarenal glands. We identified seven patients with 'high pouch output' out of 320 patients observed. The control group consisted of 14 proctocolectomized patients without hints of complications in the endoscopic, radiographic and routine laboratory diagnostics.
  
  
  RESULTS
  Neither group showed any significant differences in the analysis of the routine parameters. A significant drop of the urine sodium concentration of 40.5 +/- 18.7 mmol/l (control group 98 +/- 43.4 mmol/l) was observed in the group with 'high pouch output'. In this group the plasma aldosterone values were strongly increased with an average of 42.6 +/- 28.9 ng/dl (control group 13.2 +/- 6.8 ng/dl) as well as the plasma 18-hydroxycorticosterone with an average of 153.7 +/- 121.1 ng/dl (control group 153.7 +/- 121.1 ng/dl). Neither group of patients showed increased activity of free corticosterone and free cortisol. Only free 11-desoxycorticosterone was elevated in the group with 'high pouch output'.
  
  
  CONCLUSIONS
  Our results prove that the mineralocorticoid adrenal activity plays a central role in order to preserve the volume and electrolyte homeostasis. The low frequency of 'high-pouch-output'-complications in realms of the restorative proctocolectomy proves the excellent compensation of the removal of the colon mucosa. Plasma aldosterone seems to be a diagnostic marker encapsulating the reabsorption problems of intestinal salt and volume losses after proctocolectomy.
authors.affiliation: Chirurgische Universitätsklinik, Heidelberg.
authors.forename: F X
authors.initials: FX
authors.lastname: Huber
authors.forename: U
authors.initials: U
authors.lastname: Hinz
authors.forename: D
authors.initials: D
authors.lastname: Haack
authors.forename: M
authors.initials: M
authors.lastname: Lucas
authors.forename: U
authors.initials: U
authors.lastname: Heuschen
authors.forename: C
authors.initials: C
authors.lastname: Herfarth
authors.forename: J
authors.initials: J
authors.lastname: Stern
mesh_terms: D015069:18-Hydroxycorticosterone / Q000097:blood; D011125:Adenomatous Polyposis Coli / Q000601:surgery*; D000311:Adrenal Glands / Q000503:physiopathology; D000328:Adult; D000450:Aldosterone / Q000097:blood; D003093:Colitis, Ulcerative / Q000601:surgery*; D005260:Female; D006706:Homeostasis; D006801:Humans; D007081:Ileostomy; D008297:Male; D008901:Mineralocorticoids / Q000097:blood*; D011183:Postoperative Complications / Q000175:diagnosis / Q000503:physiopathology*; D016737:Proctocolectomy, Restorative; D012086:Reoperation; D012307:Risk Factors; D014882:Water-Electrolyte Balance / Q000502:physiology*
chemical_list: D008901:Mineralocorticoids; D000450:Aldosterone; D015069:18-Hydroxycorticosterone