Synthesis of a sialic acid dimer derivative, 2'alpha-O-benzyl Neu5Ac-alph-(2-->5)Neu5Gc.
The preparation of a disaccharide 2, Neu5Ac-alpha-(2-->5)Neu5Gc having a alpha-benzyl protecting group at the reducing end, by the coupling of the easily accessible building units 4 and 5 is described. Subsequent deprotection of the coupling adduct led to the isolation of the target compound 2 in high yield.
Ren
Chien-Tai
CT
Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Chen
Chien-Sheng
CS
Wu
Shih-Hsiung
SH
D002384:Catalysis; D004187:Disaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012794:Sialic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
C454479:2'-alpha-O-benzyl N-acetylneuraminic acid-alpha-(2-5)-N-glycolylneuraminic acid; D004187:Disaccharides; D012794:Sialic Acids