title: Macrocyclic diterpenes from Euphorbia nivulia.
abstract: The latex of Euphorbia nivulia afforded two ingol diterpenes 3,12-diacetyl-8-benzoylingol (4) and 3,12-diacetyl-7-benzoyl-8-nicotinylingol (5) along with three known ingol diterpenes 1, 2,and 3, and two known triterpenes cycloart-25-en-3beta-ol and cyclonivulinol. Their structures have been assigned on the basis of their structural data as well as their acetylated products. The diterpenes 1-5 were tested for the LPS induced PGE(2) inhibition activity.
authors.affiliation: Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
authors.forename: V
authors.initials: V
authors.lastname: Ravikanth
authors.forename: V L
authors.initials: VL
authors.lastname: Niranjan Reddy
authors.forename: T
authors.initials: T
authors.lastname: Prabhakar Rao
authors.forename: P V
authors.initials: PV
authors.lastname: Diwan
authors.forename: S
authors.initials: S
authors.lastname: Ramakrishna
authors.forename: Y
authors.initials: Y
authors.lastname: Venkateswarlu
mesh_terms: D015232:Dinoprostone / Q000037:antagonists & inhibitors; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D004224:Diterpenes; D014315:Triterpenes; D015232:Dinoprostone