title: Factor V Leiden and G20210A prothrombin mutations are risk factors for very early recurrent miscarriage.
abstract: OBJECTIVE
  To determine whether there is an association between early recurrent miscarriage (before 10 weeks of pregnancy) and Factor V Leiden and G20210A prothrombin mutations.
  
  
  METHODS
  A prospective study.
  
  
  METHODS
  Department of Gynaecology and Obstetrics, Saint Antoine Hospital, Paris, France.
  
  
  METHODS
  Two groups of women: those with early unexplained recurrent miscarriage before 10 weeks of pregnancy (n = 260) and control healthy women without a previous history of thromboembolism (n = 240).
  
  
  METHODS
  Screening for defects in the protein C anticoagulant pathway was performed using the anticoagulant response to agkistrodon confortrix venom (ACV test). Protein C and Factor V Leiden mutation testing was performed for each low ACV level. Each sample was tested for the G20210A prothrombin mutation.
  
  
  RESULTS
  Factor V Leiden and G20210A mutations were found to be associated with early recurrent spontaneous miscarriage before 10 weeks of pregnancy, the odds ratios being 2.4 (95% CI 1-5) and 2.7 (95% CI 1-7), respectively. Similar results were found whether or not women had had a previous live birth.
  
  
  CONCLUSIONS
  Early recurrent miscarriage before 10 weeks of pregnancy is significantly associated with Factor V or G20210A prothrombin mutations. These results indicate a possible role for anticoagulant prevention in these early miscarriages.
authors.affiliation: Department of Obstetrics and Gynaecology, Saint Antoine Hospital, Paris, France.
authors.forename: M F
authors.initials: MF
authors.lastname: Reznikoff-Etiévan
authors.forename: V
authors.initials: V
authors.lastname: Cayol
authors.forename: B
authors.initials: B
authors.lastname: Carbonne
authors.forename: A
authors.initials: A
authors.lastname: Robert
authors.forename: F
authors.initials: F
authors.lastname: Coulet
authors.forename: J
authors.initials: J
authors.lastname: Milliez
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D005165:Factor V / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D009154:Mutation / Q000235:genetics*; D011247:Pregnancy; D011446:Prospective Studies; D011516:Prothrombin / Q000235:genetics*; D012307:Risk Factors
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin