Necrolytic migratory erythema associated with glucagonoma syndrome: a case report.
Necrolytic migratory erythema is a rare skin condition that consists of migrating areas of erythema with blisters that heal with hyperpigmentation. It usually occurs in patients with an alpha islet cell tumor of the pancreas-or glucagonoma-and when associated with glucose intolerance, anemia, hyperglucagonemia, and weight loss defines the glucagonoma syndrome. We describe a 52-year-old female patient with necrolytic migratory erythema associated with glucagonoma syndrome who had metastatic disease at presentation and passed away one week after her admission. The autopsy showed a tumor in the body of the pancreas, which was diagnosed as a neuroendocrine tumor and confirmed by immunohistochemistry. The diagnosis of necrolytic migratory erythema is a matter of great importance, since it might be an auxiliary tool for the early detection of glucagonoma.
Dal Coleto
C C
CC
Department of Dermatology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, Brazil.
de Mello
A P
AP
Piquero-Casals
J
J
Lima
F R
FR
Vilela
M A
MA
Festa-Neto
C
C
Sanches
J A
JA
D004890:Erythema / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005935:Glucagonoma / Q000150:complications* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000473:pathology; D013577:Syndrome