[Application of recombinant human epidermal growth factor on chronic ulcer wound].
OBJECTIVE
To observe the effect of recombinant human epidermal growth factor (rhEGF) on healing of chronic ulcer wound.


METHODS
From January 1999 to January 2001, twenty-six patients with chronic wounds were adopted in this study. Among them, there were 17 males and 9 females, aged from 12 to 61 years. The area of the chronic wound varied from 3 cm x 3 cm to 5 cm x 8 cm and the disease course was 7 to 16 days. These patients were treated with rhEGF in the way of sprinkling locally (400 U/10 cm2). Another 26 patients with chronic wounds were adopted as the control group and were treated with 0.9% saline in the same way. The healing time of wounds and the local and systemic reactions of patients were observed.


RESULTS
The healing time of chronic wounds was shorter obviously to about 7 days with rhEGF than that of the control group and there was significant difference between the two groups(P < 0.01).


CONCLUSIONS
rhEGF can obviously promote the healing of chronic ulcer wound.
Zhu
Jian-xin
JX
Department of Orthopedic Surgery, Sichuan Provincial People's Hospital, Chengdu Scihuan, P. R. China 610071.
Zhang
Yao-ming
YM
D000293:Adolescent; D000328:Adult; D002648:Child; D002908:Chronic Disease; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D012883:Skin Ulcer / Q000188:drug therapy* / Q000473:pathology
D011994:Recombinant Proteins; D004815:Epidermal Growth Factor