title: Diastereoselective synthesis of protected syn 1,3-diols: preparation of the C16-C24 portion of Dolabelides.
abstract: We have designed a new method to make synthons encompassing a protected syn 1,3-diol motif and an aldehyde alpha to the 1,3-dioxane ring. An additional stereocenter was also created, potentially leading to stereochemically defined 1,2,4-triols. This method was successfully applied to the synthesis of the C16-C24 portion of Dolabelides.
authors.affiliation: Laboratoire Chimie et Procédés, Ecole Nationale Supérieure des Techniques Avancées, 32 boulevard Victor, F-75015 Paris, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Grimaud
authors.forename: Romain
authors.initials: R
authors.lastname: de Mesmay
authors.forename: Joëlle
authors.initials: J
authors.lastname: Prunet
mesh_terms: D004224:Diterpenes / Q000138:chemical synthesis*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes