[Application and time-effect analysis of antibiotics among neonatal pneumonia treatment].
OBJECTIVE
To understand the results of antibiotics use in curing neonatal pneumonia and to evaluate the time-effect of different drugs.


METHODS
Through stratified sampling, all the hospitalized cases of neonatal pneumonia from 5 hospitals with different levels in Hunan province in five years were retrospectively studied. Analysis of time-effect for different antibiotics was done through Kaplan-Meier.


RESULTS
Twenty-six kinds of anti-bacterium drugs were used in 685 cases of neonatal pneumonia, among which penicillin and ampicillin were mostly used but cephalosporins also became one of the main drugs used in treating neonatal pneumonia. Most cases were discovered (51.1%) using two kinds of antibiotics during the course of diseases through time-effect analysis. We found the effect of penicillin was better than others in treating neonatal pneumonia when used as basic medicine. It was not desirable to use two or more medicines at the beginning of the treatment.


CONCLUSIONS
Penicillin and ampicillin were still the main drugs used in treating neonatal pneumonia but more cephalosporins were used than ever. The blindness in applying antibiotics should be recovered. From Kaplan-Meier analysis, we could better understand and evaluate the time-effects of different drug treatments.
Li
S
S
School Public Health of Xiangya, Medical College of Central South University, Changsha 410078, China.
Li
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X
Yang
T
T
D000667:Ampicillin / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010406:Penicillins / Q000627:therapeutic use*; D011014:Pneumonia / Q000188:drug therapy*; D012189:Retrospective Studies; D013995:Time
D002511:Cephalosporins; D010406:Penicillins; D000667:Ampicillin