title: Pyrrolo[1,2-f]phenanthridines and related non-rigid analogues as antiviral agents.
abstract: The pyrrolo[1,2-f]phenanthridines 8-22 and the corresponding non-rigid analogues 23-41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10, 11, and 13 showed a weak anti-HIV activity, whereas several pyrrolo-phenanthridines (8, 10, 16-18) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition.
authors.affiliation: Dipartimento Farmacochimico, Tossicologico e Biologico, Universita' degli Studi, Via Archirafi 32-90123, Palermo, Italy. almerico@unipa.it
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Almerico
authors.forename: Francesco
authors.initials: F
authors.lastname: Mingoia
authors.forename: Patrizia
authors.initials: P
authors.lastname: Diana
authors.forename: Paola
authors.initials: P
authors.lastname: Barraja
authors.forename: Alessandra
authors.initials: A
authors.lastname: Montalbano
authors.forename: Antonino
authors.initials: A
authors.lastname: Lauria
authors.forename: Roberta
authors.initials: R
authors.lastname: Loddo
authors.forename: Laura
authors.initials: L
authors.lastname: Sanna
authors.forename: Donatella
authors.initials: D
authors.lastname: Delpiano
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Setzu
authors.forename: Chiara
authors.initials: C
authors.lastname: Musiu
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008958:Models, Molecular; D010617:Phenanthridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D010617:Phenanthridines; D011758:Pyrroles