Grapefruit juice potentiates the anti-inflammatory effects of diclofenac on the carrageenan-induced rat's paw oedema.
The anti-inflammatory effect of diclofenac alone or in combination with double strength grapefruit juice was investigated on carrageenan-induced rat's paw oedema. Paw was measured by using a plethysmometer 3 h after injecting the phlogestic agent. There was significant inhibition (P< 0.05) of the oedematous response after oral administration of diclofenac alone (1, 2.5, 5 mg kg(-1)p.o.) in a dose-dependent manner. Coadministration of grapefruit juice (10 ml kg(-1)p.o.) orally with all doses of diclofenac, enhanced the inhibitory effect of diclofenac on rat's paw oedema. Double-strength grapefruit juice has synergistic inhibitory effect on rat's paw oedema when administered in combination with diclofenac.
Mahgoub
Afaf A
AA
Department of Pharmacology, College of Medicine, King Saud University, P. O. Box 22452, Riyadh 11495, Saudi Arabia.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002351:Carrageenan; D002957:Citrus; D004008:Diclofenac / Q000494:pharmacology*; D004357:Drug Synergism; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D006614:Hindlimb; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D002351:Carrageenan