Matrix metalloproteinases 2 and 9 in otitis media with effusion.
A qualitative and quantitative study of the presence of matrix metalloproteinase 2 (MMP 2) and matrix metalloproteinase 9 (MMP 9), in the effusions of otitis media with effusion (OME), was performed. The activity of the above enzymes was compared in thick and thin effusions, and concentrations compared in samples from children with one, two, three and four sets of ventilation tubes. The activity of both MMP 2 and MMP 9 was higher in thick than thin effusions, P = 0.07 and P = 0.04, respectively. The concentrations of MMP 9 did not vary with the number of tube insertions but those of MMP 2 did (ANOVA P < 0.05). MMPs may be involved in tympanic membrane damage and prognosis of OME.
Jennings
C R
CR
Department of Otorhinolaryngology and Head and Neck Surgery, Queen's Medical Centre, University Hospital, Nottingham, UK.
Guo
L
L
Collins
H M
HM
Birchall
J P
JP
D002648:Child; D002675:Child, Preschool; D004587:Electrophoresis, Agar Gel; D004797:Enzyme-Linked Immunosorbent Assay; D005122:Exudates and Transudates / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008876:Middle Ear Ventilation; D010034:Otitis Media with Effusion / Q000201:enzymology* / Q000601:surgery; D014783:Viscosity
D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9