title: A therapeutical outlook in "infectious" bronchial asthma.
abstract: Chronic bronchial asthma seems to be generated by abnormal functions of PMNs and eosinophils stimulated by local bacterial flora. Once stimulated, they release uncontrolled excessive amounts of ROI and various soluble mediators. These are the expression of disorders in the synthesis of SOD, catalase and other enzymes by PMNs and an excessive production of the so-called anti-inflammatory Th2 type cytokines, mainly IL-4 and IL-5 to the detriment of IFN gamma and other Th1 type cytokines. Treatment consisting of autovaccines obtained from local flora associated with immunomodulators instead of antibiotics or glucocorticoids proved to be beneficial for patients.
authors.affiliation: Cantacuzino Institute, Bucharest, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Olinescu
authors.forename: I
authors.initials: I
authors.lastname: Leveneţ
mesh_terms: D001249:Asthma / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D001424:Bacterial Infections / Q000276:immunology / Q000628:therapy*; D001980:Bronchi / Q000382:microbiology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007167:Immunotherapy; D018417:Th1 Cells / Q000502:physiology; D018418:Th2 Cells / Q000502:physiology
chemical_list: D016207:Cytokines