title: Synthesis and molecular mechanical studies of antiviral copper(II) complexes with morpholinebiguanide drug.
abstract: The synthesis and characterization of new Cu(II) complexes with morpholinebiguanide drug are described. The complexes formed have been characterized by elemental analysis, IR, UV-VIS, conductance measurements, EPR spectra and magnetic susceptibility measurements. Their biological activity is supported by the experimental data and enhanced by the theoretical ones. The morpholinebiguanide ligand and their copper(II)-complexes were studied by molecular mechanics program.
authors.affiliation: I. G. Murgulescu Institute of Physical Chemistry, Department of Coordination Chemistry, Spl. Independentei 202, 77208 Bucharest, Romania.
authors.forename: G
authors.initials: G
authors.lastname: Patrinoiu
authors.forename: L
authors.initials: L
authors.lastname: Patron
authors.forename: J
authors.initials: J
authors.lastname: Weinberg
authors.forename: S
authors.initials: S
authors.lastname: Nita
authors.forename: A
authors.initials: A
authors.lastname: Meghea
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001645:Biguanides; D002413:Cations, Divalent; D003300:Copper / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D015394:Molecular Structure; D009025:Morpholines / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013055:Spectrophotometry, Infrared
chemical_list: D000998:Antiviral Agents; D001645:Biguanides; D002413:Cations, Divalent; D009025:Morpholines; D003300:Copper; C005267:moroxydine