title: Synthesis of 2,3-disubstituted indole using palladium(II)-catalyzed cyclization with alkenylation reaction.
abstract: The reaction of ethyl 2-ethynylphenylcarbamate derivative with alkenes in the presence of a palladium(II) catalyst, copper dichloride and tetrabutylammonium fluoride (TBAF) produced 2-substituted 3-ethenylindoles during refluxing. The intramolecular cyclization reaction of ethyl 2-ethynylphenylcarbamates, which have an ethenyl part in the ethynyl group, was also used to produce carbazole derivatives.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. yasuhara@mail.pharm.tohoku.ac.jp
authors.forename: Akito
authors.initials: A
authors.lastname: Yasuhara
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Takeda
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Takao
authors.initials: T
authors.lastname: Sakamoto
mesh_terms: D000475:Alkenes; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis*; D010165:Palladium / Q000494:pharmacology*
chemical_list: D000475:Alkenes; D007211:Indoles; D010165:Palladium