Estrogenic activities of chemicals in diesel exhaust particles.
In a previous study, we focused on estrogenic activity of the hexane extract of diesel exhaust particles (DEP). The extract of hexane was first fractionated to acidic, phenolic and neutral portions according to their chemical properties, of which the neutral fraction was fractionated by column chromatography on silica gel. The chemical structures of compounds in these fractions were then analyzed. It was found that the neutral fraction of the hexane extract of DEP contains dibenzothiophene derivatives, one of which, 4,6-dimethyldibenzothiophene, possesses estrogenic activity.
Mori
Yoki
Y
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan. mori@hoku-iryo-u.ac.jp
Taneda
Shinji
S
Hayashi
Hideyuki
H
Sakushima
Akiyo
A
Kamata
Kazuyuki
K
Suzuki
Akira K
AK
Yoshino
Shin
S
Sakata
Masakatsu
M
Sagai
Masaru
M
Seki
Koh-ichi
K
D004968:Estrogens, Non-Steroidal / Q000737:chemistry / Q000633:toxicity*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011960:Receptors, Estrogen / Q000378:metabolism; D012441:Saccharomyces cerevisiae; D013876:Thiophenes / Q000737:chemistry / Q000633:toxicity; D001335:Vehicle Emissions / Q000032:analysis / Q000633:toxicity*
C414426:4,6-dimethyldibenzothiophene; D004968:Estrogens, Non-Steroidal; D007202:Indicators and Reagents; D011960:Receptors, Estrogen; D013876:Thiophenes; D001335:Vehicle Emissions