title: Vernoguinosterol and vernoguinoside, trypanocidal stigmastane derivatives from Vernonia guineensis (Asteraceae).
abstract: Two bitter stigmastane derivatives, vernoguinosterol (1) and vernoguinoside (2), have been isolated from the stem bark of Vernonia guineensis and their structures eludicated using spectroscopic methods. The new compounds exhibit trypanocidal activity.
authors.affiliation: Department of Chemistry, University of Dschang, Box 67, Dschang, Cameroon.
authors.forename: Alembert T
authors.initials: AT
authors.lastname: Tchinda
authors.forename: Apollinaire
authors.initials: A
authors.lastname: Tsopmo
authors.forename: Pierre
authors.initials: P
authors.lastname: Tane
authors.forename: Johnson F
authors.initials: JF
authors.lastname: Ayafor
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Connolly
authors.forename: Olov
authors.initials: O
authors.lastname: Sterner
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012855:Sitosterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects*
chemical_list: D012855:Sitosterols; D014344:Trypanocidal Agents; C454561:vernoguinoside; C454560:vernoquinosterol