The lambda switch: cI closes the gap in autoregulation.
The bacteriophage lambda genetic switch is still yielding surprises. A recent study reveals that a long-range interaction involving proteins bound 2.4 kilobases away from one another on the phage genome mediates negative autoregulation, solving a long-standing puzzle concerning the regulation of lysogeny.
Hochschild
Ann
A
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave. D-1, Boston, Massachusetts 02115, USA.
D010582:Bacteriophage lambda / Q000235:genetics*; D019281:Dimerization; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral / Q000235:genetics; D006706:Homeostasis / Q000235:genetics*; D008242:Lysogeny / Q000235:genetics; D008958:Models, Molecular; D011487:Protein Conformation; D021122:Protein Subunits; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D021122:Protein Subunits; D014764:Viral Proteins