[Association between DLST gene polymorphism and Alzheimer's disease].
OBJECTIVE
To investigate the association between the polymorphic alleles of dihydrolipoamide succinyltransferase (DLST) gene cDNA at position A19117G in intron 13 and C19183T in exon 14 and the risk for sporandic Alzheimer's disease (SAD).


METHODS
The polymorphism of DLST gene was detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques in 105 patients with sporadic Alzheimer disease and 109 normal controls.


RESULTS
The frequency of AT/AC genotype was found to be significantly higher in SAD patients (21%) than in controls (10%) with an odds ratio of 2.36 (P < 0.05). The frequencies of AC/AC, AT/AT genotypes and AC allele were slightly decreased in cases with SAD as compared with controls. While the frequencies of the GC/GC genotype and GC allele were slightly higher in SAD patients than in controls. However, these differences were not statistically significant (P > 0.05).


CONCLUSIONS
The AT/AC genotype of DLST gene is associated with an increased risk for SAD.
Ma
Q
Q
Department of Neurology, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, China.
Chan
P
P
Yang
J
J
D000217:Acyltransferases / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D000217:Acyltransferases; C021515:dihydrolipoamide succinyltransferase