Developmental expression profiles of Celsr (Flamingo) genes in the mouse.
Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus. The Drosophila Fmi gene regulates epithelial planar cell polarity and dendritic field deployment. The three Flamingo gene orthologs in man and rodents are named, respectively, CELSR1-3 and Celsr1-3. Celsr1 and 2 are expressed during early development, in the brain and epithelia. In this report, we characterized further Celsr genes in the mouse, and examined their developmental pattern of expression. Each Celsr is expressed prominently in the developing brain following a specific pattern, suggesting that they serve distinct functions.
Tissir
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Neurobiology Unit 2853, FUNDP School of Medicine, B5000 Namur, Belgium.
De-Backer
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Goffinet
A M
AM
Lambert de Rouvroit
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C
D000818:Animals; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D015820:Cadherins / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D005326:Fetal Proteins; D017403:In Situ Hybridization; D051379:Mice; D008957:Models, Genetic; D017434:Protein Structure, Tertiary; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics; D043562:Receptors, G-Protein-Coupled; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D014018:Tissue Distribution
D015820:Cadherins; C117380:Celsr1 protein, mouse; C498478:Celsr2 protein, mouse; C444454:Celsr3 protein, mouse; D005326:Fetal Proteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled