title: Influence of 2-substituent on the activity of imidazo[1,2-a] pyridine derivatives against human cytomegalovirus.
abstract: The synthesis of various 2-substituted imidazo[1,2-a]pyridine bearing a thioether side chain in position 3 was reported. The new compounds were characterized by 1H and 13C NMR spectra. A conformational study was obtained by X-ray crystallographic analysis for 2-biphen-4-ylimidazopyridine 7. The antiviral activity against human cytomegalovirus (HCMV) was investigated. It was strongly influenced by the nature of C-2 substituent.
authors.affiliation: Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 31 Av. Monge, 37200, Tours, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Mavel
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Renou
authors.forename: Christophe
authors.initials: C
authors.lastname: Galtier
authors.forename: Hassan
authors.initials: H
authors.lastname: Allouchi
authors.forename: Robert
authors.initials: R
authors.lastname: Snoeck
authors.forename: Graciella
authors.initials: G
authors.lastname: Andrei
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Alain
authors.initials: A
authors.lastname: Gueiffier
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D018360:Crystallography, X-Ray; D003587:Cytomegalovirus / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D011725:Pyridines; C001439:imidazo(1,2-a)pyridine