title: Antipyretic effects of dipyrone versus ibuprofen versus acetaminophen in children: results of a multinational, randomized, modified double-blind study.
abstract: This study compared the antipyretic effectiveness of acetaminophen, ibuprofen, and dipyrone in young children with fever. The results were based on a modified double-blind, randomized, multinational trial that evaluated 628 febrile children, aged 6 months to 6 years. All three drugs lowered temperature in the 555 patients completing the study. Temperature normalization rates in the ibuprofen and dipyrone groups (78% and 82%, respectively) were significantly higher than the acetaminophen group (68%, P = 0.004). After 4 to 6 hours, mean temperature in the dipyrone group was significantly lower than the other groups, demonstrating longer temperature normalization with dipyrone. All three drugs showed comparable tolerability profiles.
authors.affiliation: Hospital de Clínicas, University of São Paulo, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Wong
authors.forename: A
authors.initials: A
authors.lastname: Sibbald
authors.forename: F
authors.initials: F
authors.lastname: Ferrero
authors.forename: M
authors.initials: M
authors.lastname: Plager
authors.forename: M E
authors.initials: ME
authors.lastname: Santolaya
authors.forename: A M
authors.initials: AM
authors.lastname: Escobar
authors.forename: S
authors.initials: S
authors.lastname: Campos
authors.forename: S
authors.initials: S
authors.lastname: Barragán
authors.forename: M
authors.initials: M
authors.lastname: De León González
authors.forename: G L
authors.initials: GL
authors.lastname: Kesselring
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001831:Body Temperature / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004177:Dipyrone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D011446:Prospective Studies; D018401:Sample Size; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D004177:Dipyrone; D007052:Ibuprofen