Biocompatibility of fluorinated polyimide.
Contact between blood and biomaterial triggers a complex series of events including protein adsorption, leukocyte adhesion and activation, and complement activation. In this article, a series of fluorinated polyimides cured at a different temperatures was prepared, and the biocompatibility of the membranes was evaluated using in vitro protein adsorption, neutrophil adhesion, and complement activation experiments under static conditions. We found that protein adsorption, neutrophil adhesion, and complement activation for the polyimides significantly depends on the curing temperature and decreases with an increase in the temperature and that the polyimide has a good biocompatibility compared with poly(styrene) and polydimethylsiloxane. We concluded that the rearrangement of molecules such as CF(3), sulfone, and ketone at the outermost surface occurs because of curing, which induces an increase in the hydrophobicity and that the cured polyimide suppresses protein adsorption, neutrophil adhesion, and complement activation because of its high hydrophobicity and low surface free energy.
Kanno
M
M
Department of Industrial Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397 Japan.
Kawakami
H
H
Nagaoka
S
S
Kubota
S
S
D000327:Adsorption; D000706:Anaphylatoxins / Q000737:chemistry; D001672:Biocompatible Materials / Q000494:pharmacology*; D001798:Blood Proteins / Q000737:chemistry; D002448:Cell Adhesion; D003167:Complement Activation / Q000187:drug effects; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D018375:Neutrophil Activation / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D010796:Phthalic Anhydrides / Q000494:pharmacology; D011073:Polyamines / Q000494:pharmacology; D011506:Proteins / Q000737:chemistry; D013499:Surface Properties; D013696:Temperature
D000706:Anaphylatoxins; D001672:Biocompatible Materials; D001798:Blood Proteins; D008567:Membranes, Artificial; D010796:Phthalic Anhydrides; D011073:Polyamines; D011506:Proteins; C454118:poly(2,2'-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride-co-2,2'-bis(4-aminophenyl)hexafluoropropane)