Severe decrease in peripheral blood dendritic cells in hairy cell leukaemia.
Clinical studies in hairy cell leukaemia (HCL) have linked the frequent occurrence of infections due to intracellular pathogens and a profound monocytopenia. More recently, dendritic cells (DC), a subset of which are related to monocytes, were shown to be the professional antigen-presenting cells which stimulate the adaptive immune response. Using membrane markers and flow cytometry, we determined in peripheral blood whether various DC subsets and monocytes were impaired in HCL. Lymphoid and myeloid DC were virtually absent in five HCL patients with active disease. After treatment, both DC and monocytes recovered slowly. The decrease in DC suggests that defective antigen presentation could affect susceptibility to intracellular pathogens in HCL.
Bourguin-Plonquet
Anne
A
Service d'Immunologie Biologique, Hôpital Henri Mondor, Créteil, France. anne.plonquet@hmn.ap-hop-paris.fr
Rouard
Hélène
H
Roudot-Thoraval
Françoise
F
Bellanger
Coralie
C
Marquet
Jeanine
J
Delfau-Larue
Marie-Hélène
MH
Diviné
Marine
M
Farcet
Jean-Pierre
JP
D000328:Adult; D000368:Aged; D017951:Antigen Presentation; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002452:Cell Count; D017338:Cladribine / Q000627:therapeutic use; D003713:Dendritic Cells / Q000187:drug effects / Q000473:pathology*; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000188:drug therapy / Q000276:immunology*; D008875:Middle Aged
D000970:Antineoplastic Agents; D017338:Cladribine