[E-CD expression and its clinical significance in human bladder carcinoma].
OBJECTIVE
To invest the expression of the E-CD protein and its clinical significance in human recurrent bladder transitional cell carcinoma.


METHODS
Immunohistological chemistry method was employed to assess the expression of E-CD in 54 cases of bladder transitional cell carcinoma.


RESULTS
Decreased E-CD expression correlated with both increased grade and stage (chi(2) = 6.65, P < 0.05; chi(2) = 7.15, P < 0.01). More importantly, abnormal expression of E-CD correlated with the high recurrence in short time and the poor survival (chi(2) = 4.88, P < 0.05; Log-rank test: chi(2) = 4.6, P < 0.05).


CONCLUSIONS
The expression of E-CD is an useful parameter of malignancy of carcinoma. The detection of E-CD expression might be significant in determining the malignancy, recurrence and prognosis of bladder transitional cell carcinoma.
Hao
Y
Y
Department of Urology, Central Hospital of Shenyang, Shenyang 110024.
Zhao
C
C
Li
X
X
Teng
M
M
D000328:Adult; D000368:Aged; D015820:Cadherins / Q000378:metabolism*; D002295:Carcinoma, Transitional Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000473:pathology
D015820:Cadherins