Leishmanicidal effect of curcumin in vitro.
From a study to find anti-parasitic agents from natural resources, we found that curcumin showed the cytotoxicity against leishmania in vitro. The LD50 value of this activity was 37.6+/-3.5 microM.
Koide
Tatsuo
T
Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan.
Nose
Mitsuhiko
M
Ogihara
Yuiko
Y
Yabu
Yoshisada
Y
Ohta
Nobuo
N
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D003474:Curcumin / Q000494:pharmacology*; D018320:Leishmania major / Q000187:drug effects* / Q000254:growth & development; D007928:Lethal Dose 50; D014344:Trypanocidal Agents / Q000494:pharmacology; D014346:Trypanosoma brucei brucei / Q000187:drug effects
D000975:Antioxidants; D000981:Antiprotozoal Agents; D014344:Trypanocidal Agents; D003474:Curcumin