Comprehensive cytogenetic evaluation of a mature ovarian teratoma case.
Mature ovarian teratomas are benign ovarian germ cell tumors that usually present with a normal karyotype. There are very few reports describing chromosomal abnormalities in these tumors, none of which are recurrent. In this study we report on a mature teratoma case with clonal chromosomal alterations which include monosomies of chromosomes 6, 14, 16, and 21; trisomies of chromosomes 14 and 21; and deletions of Xq, 5p, 16p, and 17p. Comparative genomic hybridization evaluation of the sample revealed a normal profile. These findings are discussed together with the cytogenetic reports on other cases of ovarian teratomas described in the literature.
Schmid-Braz
Ana Teresa
AT
Departamento de Genética, Universidade Federal do Paraná, Caixa Postal 19071, CEP 81531-970, Curitiba, Paraná, Brazil.
Cavalli
Luciane Regina
LR
Cornélio
Déborah Afonso
DA
Wuicik
Lismeri
L
Ribeiro
Enilze M S F
EM
Bleggi-Torres
Luiz F
LF
Lima
Rubens Silveira
RS
de Andrade Urban
Cícero
C
Haddad
Bassem R
BR
Cavalli
Iglenir João
IJ
D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D010051:Ovarian Neoplasms / Q000235:genetics*; D013724:Teratoma / Q000235:genetics*