Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models.
Cancer directly affects at least one-third of the human population, but the inherited genetic determinants of cancer risk remain largely unknown. Mouse models of human cancer are helping us to understand this disease as a complex genetic trait and thus to identify the multiple genetic variant alleles involved in pathways that affect individual cancer susceptibility.
Balmain
Allan
A
Comprehensive Cancer Center, Department of Biochemistry and Biophysics, 2340 Sutter Street, University of California San Francisco, San Francisco, CA 94143, USA. abalmain@cc.ucsf.edu
D000483:Alleles; D000818:Animals; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D012307:Risk Factors