[Investigation of factors affecting the development of COPD].
OBJECTIVE
To investigate the factors which affect the development of COPD.


METHODS
88 patients with mPAP less than 20 mm Hg were followed up by 5 - 20 years. Pulmonary ventilation, blood gas analysis, ECG, pulmonary hemodynamic parameters and oxygen saturation at night were performed one time every 5 years.


RESULTS
The results showed that: 5 year, 10 year and 20 year's mortality is 6%, 25% and 43% respectively; MVV%, FEV(1)% and PaO(2) declined accompanied by the increase of PaCO(2); among 41 patients with mPAP 16 - 20 mm Hg, 20 patients' mPAP were more than 20 mm Hg and 15 patients died after 10 years' follow up. Among 16 patients with the declination of oxygen saturation, 8 patients' mPAP were more than 20 mm Hg and 6 patients died. 57 strains of infectious bacteria were found in 88 patients' sputum with 43 strains in the death group.


CONCLUSIONS
These results demonstrated that COPD is a kind of chronic diseases with high death rate; infection, decline of oxygen saturation at night and mPAP more than 16 mm Hg were high risk factors in COPD.
Zou
X
X
Respiratory Department, General Hospital of Guangzhou Unit, PLA, Guangzhou 510010.
Xin
D
D
Chi
L
L
Li
Z
Z
Qin
W
W
Weng
R
R
D000328:Adult; D000368:Aged; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000860:Hypoxia / Q000150:complications; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011651:Pulmonary Artery / Q000503:physiopathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology* / Q000503:physiopathology; D012141:Respiratory Tract Infections / Q000150:complications; D012907:Smoking / Q000009:adverse effects
D010100:Oxygen