[Relationship between retinal and glomerular microvascular lesions in experimental diabetes in rat].
OBJECTIVE
To evaluate the relationship between diabetic retinopathy (DR) and diabetic nephropathy (DN).


METHODS
The thickness of retinal capillary basement membrane (RBM) and glomerular basement membrane (GBM) and their anionic sites were quantitatively analyzed by electron microscopy and immunohistochemical methods.


RESULTS
RBM and GBM became gradually thickened with the development of diabetes. The thickened basement membrane was accompanied with decrease of anionic sites in number.


CONCLUSIONS
DR and DN share partly the pathological process, and there are also some incoordinate phenomena in the microvascular lesion.
Wei
L
L
Department of Ophthalmology, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang 050000.
Wang
C
C
Duan
H
H
Zhang
Z
Z
D000818:Animals; D002196:Capillaries / Q000473:pathology / Q000648:ultrastructure; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D003928:Diabetic Nephropathies / Q000473:pathology*; D003930:Diabetic Retinopathy / Q000473:pathology*; D005260:Female; D005920:Glomerular Mesangium / Q000098:blood supply* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D017207:Rats, Sprague-Dawley; D012171:Retinal Vessels / Q000473:pathology* / Q000648:ultrastructure