Total synthesis of the mycolactones.
[structure: see text] The first total synthesis of the mycolactones is reported. This work unambiguously confirms our earlier relative and absolute stereochemical assignment of the mycolactones.
Song
Fengbin
F
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Fidanze
Steve
S
Benowitz
Andrew B
AB
Kishi
Yoshito
Y
D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D019911:Mycobacterium ulcerans / Q000737:chemistry*
D007202:Indicators and Reagents; D007783:Lactones; D018942:Macrolides; C451488:mycolactone A; C451489:mycolactone B