Concentration profile of mRNA of kinine B1 and B2 receptors in the evaluation of colon pathologies.
Colon pathologies involve the activation of a number of inflammation mediators: cytokines, prostanoids and kinines. The expression patterns of the genes associated with their activation may provide a very sensitive marker of the physiological condition of the cells. This paper demonstrates certain statistically significant differences (p = 0.008) between the expression patterns of kinine B1 and B2 receptor encoding genes for colitis ulcerosa and a control group. The ratio of kinine B1/B2 concentrations changes significantly, on the average from 1.3 for a tissue assessed as healthy to 6.6 for colitis ulcerosa.
Mazurek
U
U
Department of Molecular Biology, Biochemistry and Biopharmacy, Medical University of Silesia, Katowice, Poland. umazurek@farmant.slam.katowice.pl
Pastucha
E
E
Orchel
J
J
Bierzyńska-Macyszyn
G
G
Cholewa
K
K
Stadnicki
A
A
Wilczok
T
T
D003093:Colitis, Ulcerative / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D043783:Receptor, Bradykinin B1; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin / Q000235:genetics*; D019914:Taq Polymerase
D012333:RNA, Messenger; D043783:Receptor, Bradykinin B1; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin; D019914:Taq Polymerase