[Relation between uricemia and total, cardiovascular and coronary mortality in both genders of non-selected sample of the Belgium population].
BACKGROUND
Despite more than 40 years of research on the prognostic value of hyperuricemia in relation to all-causes cardiovascular and coronary mortality, no clear consensus appears in the medical literature. Moreover, the observed relationship between hyperuricemia and the incidence of coronary heart disease mortality is related to gender. However, prospective studies including both genders are rare.


METHODS
A prospective study was conducted in a random sample of 5225 males and 4476 females from the Belgian population aged 25 to 74 years at the initial survey and followed for 10 years for all-causes and specific mortality.


RESULTS
The number of observed total, cardiovascular, and coronary heart disease deaths were 648 and 239, 150 and 225, and 96 and 51 in males and females respectively. At multivariate analysis, uricemia was significantly correlated with all-causes mortality in males whereas a tendency was observed in females. The same diverging association was observed for cardiovascular mortality. However, for coronary heart disease mortality, there was a very significant correlation only in females.


CONCLUSIONS
Our findings confirm the observed gender-related differences in the relation of hyperuricemia with all-causes and coronary heart disease mortality. We propose possible pathogenic mechanisms concerning the relationship with coronary heart disease mortality observed only in females.
Aboa Eboule
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AC
Ministère de la Santé Publique, Institut de Cardiologie d'Abidjan, 22 BP 1048 Abidjan 22, République de Côte d'Ivoire.
De Smet
P
P
Dramaix
M
M
De Backer
G
G
Kornitzer
M
M
D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D001530:Belgium; D002318:Cardiovascular Diseases / Q000401:mortality*; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends*; D015999:Multivariate Analysis; D011446:Prospective Studies; D012307:Risk Factors; D012494:Sampling Studies; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D013997:Time Factors; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid