[Intrahepatic portal vein compliance in cirrhosis].
OBJECTIVE
To elaborate the effects of increase in portal flow on intrahepatic vein compliance with isolated perfused cirrhotic model (IPCM).


METHODS
Cirrhosis was induced by CCl(4) in 80 Wistar rats, which were divided into two groups A and B, by portal with/without hepato-artery. Portal flow was increased and hemodynamic parameters were recorded and analysed.


RESULTS
In group A, compared with 1.65 +/- 0.28 kPa at basal control, portal pressure was elevated from 2.55 +/- 0.40 kPa to 3.96 +/- 0.67 kPa. Q(35)-Q(55) flow rates were raised from 35 to 55 ml/min, respectively. A correlation existed between portal flows and pressures (r = 0.985, P < 0.01). The low flow rate of 15 ml/min at Q(15) caused a irreversible model injury. A largest flow rate in IPCM was, less than in IPRL. In group B, no low flow-injury was found.


CONCLUSIONS
Portal vein compliance of liver is decreased markedly in cirrhotic portal hypertension, but hepatic flow is increased. There are likely some compensative relations between portal and hepato-arterial system.
Zheng
E
E
Department of Surgery, People's Hospital, Beijing Medical University, Beijing 100044.
Leng
X
X
Liu
J
J
Xu
Q
Q
Peng
J
J
Du
R
R
D000818:Animals; D008102:Liver Circulation; D008106:Liver Cirrhosis, Experimental / Q000503:physiopathology*; D008297:Male; D017082:Portal Pressure; D011169:Portal Vein / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow; D014655:Vascular Resistance