Loss of heterozygosity on chromosome 11 in esophageal squamous cell carcinomas.
Esophageal cancer (ESC) is an important cancer worldwide. Chromosome 11 plays an important role in the development of several human cancers. In this study, 19 polymorphic microsatellite markers spanning the whole chromosome 11 were used to screen for loss of heterozygosity (LOH) in 38 primary esophageal squamous cell carcinomas. Thirty-three of 38 samples (86.8%) showed LOH at one or more loci. High frequencies (51.9-61.1%) of allelic loss were observed at D11S1338, D11S2000, D11S1990, and D11S1647 loci, in two chromosomal regions, 11p15.5 and 11q22.3. The results of this study suggest the presence of putative tumor suppressor genes in these two regions on chromosome 11 related to ESC.
Lam
Chi Tat
CT
Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, (SAR), Hong Kong, People's Republic of China.
Tang
Cecilia Man Ching
CM
Lau
Kwok Wai
KW
Lung
Maria Li
ML
D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics*; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000235:genetics; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D012907:Smoking / Q000009:adverse effects; D015996:Survival Rate