[Prediction of individual radio-resistance in animals by the parameters of initial endocrine functioning of the organism].
Predictability of individual radioresistance by initial parameters of endocrine functions, i.e. peripheral blood levels of adrenal hormones (corticosterone) and thyroid hormones (triiodthyronin and thyroxin) was tested. An integral logarithmic index of parameter deviation from the mean statistical norm was used as a predictive criterion. The initial corticosterone content was found to be very informative of future radioresistance and allowed identification of subgroups of animals whose survivability reached 92.3% against group-average 57.2%. Triiodthyronin also turned to be a predictor as survivability of animals positively qualified by the parameter made up 83.5%. In the experiment with irradiation of rats with a higher dose resulting in group-average survivability of 28.7%, a subgroup with 2.2-fold higher survivability was identified.
Shtemberg
A S
AS
Shafirkov
A V
AV
Shikhov
S N
SN
D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D005544:Forecasting; D011832:Radiation Injuries / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013963:Thyroid Hormones / Q000378:metabolism*
D013963:Thyroid Hormones