title: Solid-phase synthesis of c(RGDfK) derivatives: on-resin cyclisation and lysine functionalisation.
abstract: The cyclic pentapeptide c(RGDfK), a selective ligand for the alpha(v)beta3 integrin, was synthesised on solid phase. All synthetic operations including the cyclisation step and the appendage of the Bolton-Hunter reagent was conducted on-resin.
authors.affiliation: Department of Chemistry, Leeds University, LS2 9JT, Leeds, UK.
authors.forename: Catherine F
authors.initials: CF
authors.lastname: McCusker
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Kocienski
authors.forename: F Thomas
authors.initials: FT
authors.lastname: Boyle
authors.forename: Andreas G
authors.initials: AG
authors.lastname: Schätzlein
mesh_terms: D003500:Cyclization; D039302:Integrin alphaVbeta3; D008024:Ligands; D008239:Lysine / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D012117:Resins, Synthetic / Q000737:chemistry
chemical_list: D039302:Integrin alphaVbeta3; D008024:Ligands; D010456:Peptides, Cyclic; D012117:Resins, Synthetic; C099250:cyclic (arginyl-glycyl-aspartyl-phenylalanyl-lysyl); D008239:Lysine