Beta-carboline-carbohydrate hybrids: molecular design, chemical synthesis and evaluation of novel DNA photocleavers.
Beta-carboline present in beta-carboline alkaloids from marine organisms was found, for the first time, to cleave DNA at the guanine site upon irradiation with UV light with a long wavelength without any additive, and beta-carboline-carbohydrate hybrid system was effective for DNA cleavage.
Toshima
Kazunobu
K
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, 223-8522, Yokohama, Japan. toshima@apple.keio.ac.jp
Okuno
Yukiko
Y
Nakajima
Yoko
Y
Matsumura
Shuichi
S
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002241:Carbohydrates / Q000737:chemistry / Q000494:pharmacology*; D002243:Carbolines / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D015195:Drug Design; D015394:Molecular Structure; D010777:Photochemistry; D010789:Phototherapy / Q000379:methods; D014466:Ultraviolet Rays
D000970:Antineoplastic Agents; D002241:Carbohydrates; D002243:Carbolines; D004247:DNA