[Correlation between epidermal growth factor receptor messenger RNA expression and the onset of labor].
OBJECTIVE
To study the correlation between epidermal growth factor receptor messenger RNA expression and the onset of labor.


METHODS
Semiquantitative reverse transcriptase polymerase chain reaction, using GAPDH as internal standard, was applied to determine the levels of epidermal growth factor receptor messenger RNA in human myometrium (n = 20) and fetal membranes (n = 20) before and during labor.


RESULTS
In myometrium, epidermal growth factor receptor messenger RNA increased from 0.91 +/- 0.32 before labor to 1.33 +/- 0.23 after the onset of labor (P < 0.05). In fetal membranes, epidermal growth factor receptor messenger RNA increased from 1.05 +/- 0.30 before labor to 1.65 +/- 0.71 after the onset of labor (P < 0.05).


CONCLUSIONS
The study indicates it is Up-regulation of epidermal growth factor receptors messenger RNA expression in myometrium and fetal membrane before and after the onset of labor.
Chen
J
J
Departrnent of Obstetrics and Gynecology, The Second Affiliated Hospital, Hunan Medical University, Changsha 410008, China.
Zeng
W
W
Wu
J
J
D000650:Amnion / Q000378:metabolism; D066246:ErbB Receptors / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D006801:Humans; D007745:Labor Onset / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014599:Uterus / Q000378:metabolism*
D012333:RNA, Messenger; D066246:ErbB Receptors