[Assessing the chemical cross-reaction from cefixime and some nonsteroidal anti-inflammatory agents in a soluble formulation].
The presence of chemical cross-reactivity between drugs may be an underestimated factor, responsible for decreased bio-availability of a drug active component(s); the absence of chemical cross-reactivity between drugs is undoubtedly the prerequisite for their simultaneous co-administration. Here, by means of thin layer chromatography, we show that cefixime, a third generation oral cephalosporin, does not display chemical reactivity versus a series of non-steroidal antiinflammatory agents. The four compounds tested can therefore be safely soluted together with the cephalosporin.
Bolognesi
M
M
Centro di Biotecnologie Avanzate, Università degli studi di Genova, Genova, Italy.
Spallarossa
A
A
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D020682:Cefixime / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002855:Chromatography, Thin Layer
D000894:Anti-Inflammatory Agents, Non-Steroidal; D020682:Cefixime