[Hormonal perturbations in fibromyalgia].
Fibromyalgia is a syndrome characterized by chronic musculoskeletal pain and fatigue without biological detectable disturbances. The mechanisms of this disease are unknown. It has been postulated that it can be the consequence of a chronic stress mediated mainly through the hypothalamo-pituitary-adrenal axis and the sympathetic nervous system. These fields have been extensively studied. Results were scattered and non convincing. A reduction of growth hormone and IGF-1 levels described in a third of patients has led to a double blind random clinical trial with biogenetic growth hormone. Results were equivocal . Other hormonal systems are grossly normals and circadian rhythms are unaltered. Despite some arguments in favour of a CRH neurons hyperactivity, these results are not able to consolide a particular physiopathological mechanism and to argument for a new therapeutic approach. Many of the abnormalities may be the consequence of psychological disturbances.
Schlienger
J L
JL
Service de Médecine Interne et de Nutrition, Hôpital de Hautepierre, 67098 Strasbourg Cedex, France.
Perrin
A E
AE
Grunenberger
F
F
Goichot
B
B
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D002940:Circadian Rhythm; D003346:Corticotropin-Releasing Hormone; D005221:Fatigue / Q000209:etiology; D005260:Female; D005356:Fibromyalgia / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000523:psychology; D006728:Hormones / Q000097:blood*; D019382:Human Growth Hormone / Q000172:deficiency / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007037:Hypothyroidism / Q000150:complications; D007334:Insulin-Like Growth Factor I / Q000172:deficiency; D015850:Interleukin-6; D008297:Male; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011388:Prolactin / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000503:physiopathology
D006728:Hormones; D015850:Interleukin-6; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone