title: Correlation of serum levels of soluble intercellular adhesion molecule-1 with disease activity in systemic lupus erythematosus.
abstract: Intercellular adhesion molecule-1 (ICAM-1) is a membrane-bound molecule primarily involved in cell-cell adhesive interactions of the immune system. It is a cytokine-induced glycoprotein involved in the recruitment of cells into tissues undergoing inflammatory responses. The levels of soluble ICAM-1 were measured in sera of patients with systemic lupus erythematosus (SLE) using sandwich enzyme-linked immunoassay. Serum levels (mean +/- SD) of soluble ICAM-1 (sICAM-1) were significantly higher in 24 patients with SLE than in 20 controls (372+/-42 ng/dL vs 231+/-29 ng/dL, P < 0.001). A statistically significant positive correlation was observed between sICAM-1 levels and SLE disease activity index (SLEDAI) score in SLE patients, and no correlation was found between sICAM-1 and CRP, SLEDAI and CRP, or SLEDAI and ESR in patient groups (P>0.05). These findings suggest that sICAM-1 measurement may serve as an additional serologic marker of disease activity in patients with SLE.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Atatürk University, Erzurum, Turkey. refikali@yahoo.com
authors.forename: Refik Ali
authors.initials: RA
authors.lastname: Sari
authors.forename: Seyithan
authors.initials: S
authors.lastname: Taysi
authors.forename: Fuat
authors.initials: F
authors.lastname: Erdem
authors.forename: Omer
authors.initials: O
authors.lastname: Yilmaz
authors.forename: Said
authors.initials: S
authors.lastname: Keleş
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kiziltunç
authors.forename: Ali Rýza
authors.initials: AR
authors.lastname: Odabaş
authors.forename: Ramazan
authors.initials: R
authors.lastname: Cetinkaya
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011336:Probability; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012995:Solubility; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1