title: Liver enzymes as predictors of liver damage due to blunt abdominal trauma in children.
abstract: BACKGROUND
  Blunt abdominal trauma in children can result in injury to the liver. In hemodynamically stable patients, initial evaluation of liver transaminase levels may be useful in determining the need for computed tomography (CT).
  
  
  METHODS
  We reviewed the medical records of 44 hemodynamically stable children who had abdominal CT and who also had liver enzyme determinations as the initial workup.
  
  
  RESULTS
  Liver enzymes were found to be elevated in all but one patient with CT confirmed hepatic injury. The sensitivity and specificity of elevated liver enzyme levels were 92.9% and 100%, respectively, for predicting liver injury.
  
  
  CONCLUSIONS
  When hemodynamically stable pediatric patients with blunt abdominal trauma have AST levels >400 and/or ALT levels >250 IU/L, abdominal CT is indicated. Children in this study with serum transaminase levels below these values were at decreased risk of liver injury.
authors.affiliation: Division of Trauma Services, Broward General Medical Center, Fort Lauderdale, FL, USA.
authors.forename: Subhash R
authors.initials: SR
authors.lastname: Puranik
authors.forename: Janice S
authors.initials: JS
authors.lastname: Hayes
authors.forename: Julie
authors.initials: J
authors.lastname: Long
authors.forename: Maria
authors.initials: M
authors.lastname: Mata
mesh_terms: D000007:Abdominal Injuries / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000201:enzymology; D000367:Age Factors; D002648:Child; D005260:Female; D006801:Humans; D008099:Liver / Q000293:injuries*; D008111:Liver Function Tests; D008297:Male; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014949:Wounds, Nonpenetrating / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000201:enzymology