title: A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor.
abstract: Replacement of the thiol groups in 1, a potent and highly selective Candida albicans GGTase I inhibitor discovered through screening, with an imidazole ring was achieved by using solid phase synthesis. A non-thiol compound, 7, was found as a representative of a new class of potent C. albicans GGTase I inhibitor with high selectivity against human GGTase I.
authors.affiliation: Banyu Tsukuba Research Institute, Okubo-3, Tsukuba 300-2611, Ibaraki, Japan. sunamist@banyu.co.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sunami
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ohkubo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sagara
authors.forename: Jun
authors.initials: J
authors.lastname: Ono
authors.forename: Shuichi
authors.initials: S
authors.lastname: Asahi
authors.forename: Seita
authors.initials: S
authors.lastname: Koito
authors.forename: Hajime
authors.initials: H
authors.lastname: Morishima
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000145:classification / Q000494:pharmacology; D002176:Candida albicans / Q000201:enzymology; D020650:Combinatorial Chemistry Techniques; D004151:Dipeptides; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D004151:Dipeptides; D004791:Enzyme Inhibitors; D007093:Imidazoles; C029899:imidazole