title: Beta-oxidation of conjugated linoleic acid isomers and linoleic acid in rats.
abstract: To assess the oxidative metabolism of conjugated linoleic acid (CLA) isomers, rats were force-fed 1.5-2.6 MBq of [1-14C]-linoleic acid (9c,12c-18:2), -rumenic acid (9c,11t-18:2), or-10trans,12cis-18:2 (10t,12c-18:2), and 14CO2 production was monitored for 24 h. The animals were then necropsied and the radioactivity determined in different tissues. Both CLA isomers were oxidized significantly more than linoleic acid. Moreover, less radioactivity was recovered in most tissues after CLA intake than after linoleic acid intake. The substantial oxidation of CLA isomers must be considered when assessing the putative health benefits of CLA supplements.
authors.affiliation: INRA, Unité de Nutrition Lipidique, Dijon, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Sergiel
authors.forename: J M
authors.initials: JM
authors.lastname: Chardigny
authors.forename: J L
authors.initials: JL
authors.lastname: Sébédio
authors.forename: O
authors.initials: O
authors.lastname: Berdeaux
authors.forename: P
authors.initials: P
authors.lastname: Juaneda
authors.forename: O
authors.initials: O
authors.lastname: Loreau
authors.forename: B
authors.initials: B
authors.lastname: Pasquis
authors.forename: J P
authors.initials: JP
authors.lastname: Noel
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes; D008041:Linoleic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D013237:Stereoisomerism; D014018:Tissue Distribution
chemical_list: D002250:Carbon Radioisotopes; D008041:Linoleic Acids