Why we need to know whether prophylactic antibiotics can reduce measles-related morbidity.
In some parts of the world, measles vaccination has resulted in very substantial reductions in measles-related morbidity and mortality. Even so, it has been estimated that 30 million people still contract the disease every year, that nearly 1 million of these die, and that measles-related deaths account for about 10% of all deaths in children under the age of 5 in developing countries. Existing evidence from controlled trials suggests that antibiotic prophylaxis in measles can result in important reductions in measles-related morbidity, and, at a World Health Organization meeting convened in 1993 to decide on research priorities for the treatment of measles, highest priority was accorded to additional controlled trials of prophylactic antibiotics. As controlled trials of vitamin A in measles have made clear, such trials are feasible. Continued acquiescence in uncertainties about the effects of prophylactic antibiotics in a disease that continues to afflict so many children worldwide is unacceptable.
Chalmers
Iain
I
UK Cochrane Centre, NHS Research and Development Programme, Summertown Pavilion, Middle Way, Oxford OX2 7LG, United Kingdom. ichalmers@cochrane.co.uk
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D018849:Controlled Clinical Trials as Topic / Q000706:statistics & numerical data; D024881:Drug Resistance, Bacterial; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D008171:Lung Diseases / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control; D008457:Measles / Q000150:complications* / Q000188:drug therapy / Q000401:mortality*; D008458:Measles Vaccine / Q000627:therapeutic use; D015163:Superinfection / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D008458:Measles Vaccine