Effects of recombinant human basic fibroblast growth factor on cell proliferation during mandibular fracture healing in rabbits.
OBJECTIVE
To investigate the effects of recombinant human basic fibroblast growth factor (rhbFGF) on the cell proliferation during mandibular fracture healing in rabbits.


METHODS
The complex of rhbFGF and bovine type I collagen was implanted into the mandibular fracture site under periosteum of the animal. The whole mandible was harvested at 7, 14, 28, 56 and 84 days respectively after operation. The expression of proliferating cell nuclear antigen (PCNA) in callus was examined with immunohistochemical staining.


RESULTS
PCNA-positive cells in callus in the rhbFGF-treated group on days 7 and 14 were more than that in the control group (P<0.01).


CONCLUSIONS
It indicates that rhbFGF can stimulate cell proliferation during mandibular fracture healing in rabbits.
Gong
Z
Z
Department of Oral-Maxillofacial Surgery, College of Stomatology, Fourth Military Medical University, Xi'an, 710032, China.
Zhou
S
S
Cao
J
J
Gu
X
X
D000818:Animals; D016222:Fibroblast Growth Factor 2 / Q000627:therapeutic use*; D008337:Mandibular Fractures / Q000628:therapy*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D011817:Rabbits; D011994:Recombinant Proteins / Q000627:therapeutic use*
D018809:Proliferating Cell Nuclear Antigen; D011994:Recombinant Proteins; D016222:Fibroblast Growth Factor 2