Synthesis of 2,2'-dihydroxybisphenols and antiviral activity of some bisphenol derivatives.
New diphenylmethane-type 2,2'-dihydroxybisphenols (5a-d) were prepared regioselectively in good yields. We evaluated the antiviral activity of some bisphenol derivatives synthesized by the plaque reduction assay. Most of the compounds showed significant antiviral activity and the 4,4'-dihydroxybisphenol derivative (10) showed higher activity than 2,2'-bisphenol derivatives. This compound had EC50 value of 1.8 microg/ml.
Sumoto
Kunihiro
K
Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan. kunihiro@cis.fukuoka-u.ac.jp
Mibu
Nobuko
N
Yokomizo
Kazumi
K
Uyeda
Masaru
M
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology
D000998:Antiviral Agents; D010636:Phenols