Polymorphisms of interferon-gamma gene CA-repeat and interleukin-10 promoter region (-592A/C) in Japanese type I diabetes.
We investigated the association of the polymorphisms of interferon-gamma gene (IFNG) CA-repeat and IL-10-592A/C with clinical heterogeneity of type I diabetes as well as susceptibility to type I diabetes. Two hundred seven Japanese type I diabetic patients and 160 healthy control subjects were studied in this case-control study. No significant differences of global IFNG allele frequencies were found between controls and type I diabetic patients, and between each subgroup of the patients and controls. When compared with controls, the a12 allele was increased in the patients with age at onset <25 years (p 0.0241, p(c) = 0.1205), and a significant increased frequency of the a12 positive genotype was observed in the patients with age at onset <25 years (p(c) = 0.0121). There were no differences of IL-10-592 genotype and allele frequencies between controls and type I diabetes. However, the frequency of the -592*C allele was significantly increased in the patients with highly positive-GADab compared with controls (p(c) = 0.0060) or compared with the GADab-negative type I patients (p(c) = 0.0276). These results suggest that the IFNG CA-repeat and the IL-10-592A/C polymorphisms are not strong determinants of susceptibility to the development of type I diabetes in Japanese individuals. However, both the IFNG CA-repeat and the IL-10-592A/C polymorphisms are associated with clinical heterogeneity in type I diabetes.
Tegoshi
Hisataka
H
First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hasegawa
Goji
G
Obayashi
Hiroshi
H
Nakano
Koji
K
Kitagawa
Yoshihiro
Y
Fukui
Michiaki
M
Matsuo
Satoshi
S
Deguchi
Masako
M
Ohta
Mitsuhiro
M
Nishimura
Masataka
M
Nakamura
Naoto
N
Yoshikawa
Toshikazu
T
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics*; D007564:Japan; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
D001323:Autoantibodies; D016753:Interleukin-10; D007371:Interferon-gamma; D005968:Glutamate Decarboxylase