Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study.
OBJECTIVE
To investigate whether measles, mumps, and rubella (MMR) vaccination is associated with bowel problems and developmental regression in children with autism, looking for evidence of a "new variant" form of autism.


METHODS
Population study with case note review linked to independently recorded vaccine data.


METHODS
Five health districts in north east London.


METHODS
278 children with core autism and 195 with atypical autism, mainly identified from computerised disability registers and born between 1979 and 1998.


METHODS
Recorded bowel problems lasting at least three months, age of reported regression of the child's development where it was a feature, and relation of these to MMR vaccination.


RESULTS
The proportion of children with developmental regression (25% overall) or bowel symptoms (17%) did not change significantly (P value for trend 0.50 and 0.47, respectively) during the 20 years from 1979, a period which included the introduction of MMR vaccination in October 1988. No significant difference was found in rates of bowel problems or regression in children who received the MMR vaccine before their parents became concerned about their development (where MMR might have caused or triggered the autism with regression or bowel problem), compared with those who received it only after such concern and those who had not received the MMR vaccine. A possible association between non-specific bowel problems and regression in children with autism was seen but this was unrelated to MMR vaccination.


CONCLUSIONS
These findings provide no support for an MMR associated "new variant" form of autism with developmental regression and bowel problems, and further evidence against involvement of MMR vaccine in the initiation of autism.
Taylor
Brent
B
Centre for Community Child Health, Royal Free and University College Medical School, University College London Royal Free Campus, London. b.taylor@rfc.ucl.ac.uk
Miller
Elizabeth
E
Lingam
Raghu
R
Andrews
Nick
N
Simmons
Andrea
A
Stowe
Julia
J
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007410:Intestinal Diseases / Q000453:epidemiology / Q000209:etiology*; D016015:Logistic Models; D008131:London / Q000453:epidemiology; D022542:Measles-Mumps-Rubella Vaccine / Q000009:adverse effects*; D008498:Medical Record Linkage; D014611:Vaccination / Q000009:adverse effects
D022542:Measles-Mumps-Rubella Vaccine