Placental site trophoblastic tumor (PSTT) in mother and child: first report of PSTT in infancy.
BACKGROUND
To the authors' knowledge, placental site trophoblastic tumors occurring simultaneously in mother and infant have not previously been reported.


METHODS
The clinicopathologic features of metastatic placental site trophoblastic tumor in a mother and her 4-month-old son are described.


RESULTS
The disease in the infant was aggressive, and he died in multiorgan failure within 5 weeks of hospital admission. Autopsy showed widespread metastases to liver, lungs, pleura, kidney, mesentery and lymph nodes. The mother, who had a uterine tumor and lung metastases, was treated with chemotherapy and hysterectomy and has no evidence of disease 26 months post-treatment.


CONCLUSIONS
This report shows that placental site trophoblastic tumors can metastasize in both mother and child.
Monclair
Tom
T
Pediatric Surgical Service, Department of Surgery, The National Hospital, Rikshospitalet, Oslo, Norway. tom.monclair@rikshospitalet.no
Abeler
Vera M
VM
Kaern
Janne
J
Walaas
Lisa
L
Zeller
Bernward
B
Hilstrøm
Carsten
C
D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007223:Infant; D008113:Liver Neoplasms / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008297:Male; D011247:Pregnancy; D018245:Trophoblastic Tumor, Placental Site / Q000473:pathology / Q000556:secondary / Q000601:surgery; D014594:Uterine Neoplasms / Q000473:pathology / Q000601:surgery