title: Penicillin-resistant Aerococcus viridans bacteremia associated with granulocytopenia.
abstract: Aerococcus viridans, a catalase-negative gram-positive coccus rarely causing bacteremia, was isolated from blood cultures of a 52-yr-old man under the granulocytopenic condition. The isolate showed the typical characteristics of A. viridans, i.e., tetrad arrangements in gram stain, positive pyrrolidonyl aminopeptidase (PYR) and negative leucine aminopeptidase (LAP) reactions, and no growth at 45 degrees C. The isolate was revealed to be highly resistant to penicillin, erythromycin, clindamycin, and ceftriaxone, although most strains of A. viridans isolated from the previously reported patients were susceptible to penicillin and other commonly used antibiotics. Even though A. viridans is rarely associated with human infections, it could be a potential causative agent of bacteremia, especially in immunocompromised patients.
authors.affiliation: Department of Clinical Pathology, Yonsei University Wonju College of Medicine, 162 Ilsan-dong, Wonju 220-701, Korea. u931018@wonju.yonsei.ac.kr
authors.forename: Young
authors.initials: Y
authors.lastname: Uh
authors.forename: Jeong Seog
authors.initials: JS
authors.lastname: Son
authors.forename: In Ho
authors.initials: IH
authors.lastname: Jang
authors.forename: Kap Jun
authors.initials: KJ
authors.lastname: Yoon
authors.forename: Soon Ki
authors.initials: SK
authors.lastname: Hong
mesh_terms: D000380:Agranulocytosis / Q000150:complications* / Q000382:microbiology / Q000503:physiopathology; D016470:Bacteremia / Q000150:complications* / Q000382:microbiology / Q000503:physiopathology; D002443:Ceftriaxone / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D016908:Gram-Positive Bacterial Infections / Q000150:complications* / Q000382:microbiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000494:pharmacology*; D013289:Streptococcaceae / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D010406:Penicillins; D002981:Clindamycin; D004917:Erythromycin; D002443:Ceftriaxone