title: Novel steroidal vinyl fluorides as inhibitors of steroid C17(20) lyase.
abstract: 20-fluoro-17(20)-pregnenolone derivatives were designed as enol mimics of pregnenolone. All of the targeted, novel fluoroolefins were potent inhibitors of C17(20) lyase.
authors.affiliation: Aventis Pharmaceuticals, Route 202-206, Bridgewater, NJ 08807-0800, USA.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Burkhart
authors.forename: Philip M
authors.initials: PM
authors.lastname: Weintraub
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Gates
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Resvick
authors.forename: Roy J
authors.initials: RJ
authors.lastname: Vaz
authors.forename: Dirk
authors.initials: D
authors.lastname: Friedrich
authors.forename: Michael R
authors.initials: MR
authors.lastname: Angelastro
authors.forename: Philippe
authors.initials: P
authors.lastname: Bey
authors.forename: Norton P
authors.initials: NP
authors.lastname: Peet
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D008252:Macaca fascicularis; D011284:Pregnenolone / Q000031:analogs & derivatives; D013254:Steroid 17-alpha-Hydroxylase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013259:Steroids, Fluorinated / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013259:Steroids, Fluorinated; D014753:Vinyl Compounds; C016829:vinyl fluoride; D011284:Pregnenolone; D013254:Steroid 17-alpha-Hydroxylase