Adherence of Aspergillus species to soft contact lenses and attempts to inhibit the adherence.
The aim of this research was to assess the adherence of various Aspergillus species (A. niger, A. fumigatus, A. flavus) to contact lenses with different water content and to attempt to inhibit the adherence of Aspergillus spp. to the contact lenses by a chitin derivative (CSE). Adherence of Aspergillus spp. to lenses with higher water content was greater. Differences were found between the adherence levels of various Aspergillus species to contact lenses with different water content. CSE significantly inhibits the adherence in vitro of A. niger, A. fumigatus and A. flavus to soft contact lenses. These findings suggest a possibility for prevention of fungal ocular infections caused by Aspergillus spp. in wearers of contact lenses.
Sionov
E
E
Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Israel.
Sandovsky-Losica
H
H
Gov
Y
Y
Segal
E
E
D001230:Aspergillus / Q000502:physiology*; D002448:Cell Adhesion / Q000187:drug effects*; D002686:Chitin / Q000494:pharmacology*; D003261:Contact Lenses / Q000382:microbiology*; D004305:Dose-Response Relationship, Drug
D002686:Chitin