[Language and learning disorders in epilepsy with continuous spike-waves during slow sleep].
Efficacy of antiepileptic drugs in children with epilepsy is usually evaluated on the basis of reduction in seizure frequency. However, in a number of cases, the effect of a drug in reducing EEG paroxysmal activity should be considered. This applies particularly to Landau-Kleffner syndrome and to the syndrome of continuous spike-waves during slow sleep. In developmental language disorders, EEG paroxysmal activity is present in almost 30% of the cases. Paroxysmal abnormalities are usually less frequent than what is observed in epilepsy with continuous spike-waves during slow sleep. Pathogenesis remains unknown and the relationship between EEG evolution and language improvement is not as clear as in Landau-Kleffner syndrome.
Billard-Daudu
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Hôpital Kremlin-Bicêtre, 78, rue du Général-Leclerc, 94175 Le Kremlin-Bicêtre, France.
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D007805:Language Development Disorders / Q000175:diagnosis* / Q000188:drug therapy; D007859:Learning Disabilities / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D017286:Polysomnography; D011379:Prognosis; D012893:Sleep Wake Disorders / Q000175:diagnosis* / Q000188:drug therapy
D000927:Anticonvulsants