[The preliminary analysis of domestic hydrogel microspheres for endovascular embolization].
OBJECTIVE
To evaluate the embolic effects and biocompatibility of domestic hydrogel microspheres (HMs).


METHODS
22 domestic rabbits were used. 0.03 g/2ml, 0.06 g/2ml domestic Hms of 70 - 150 microm and 2 ml normal saline were injected respectively through catheterization in the right common carotid arteries of rabbits. The changes in neurologic functions, general state and average weight of rabbits were observed, and the histomorphological changes of embolized arteries and surrounding tissues were evaluated by analysis of macroscopy and light microscope.


RESULTS
Rabbits' neurologic symptoms (hemiparalysis, convulsion and hypotonia) and death were observed after embolization. Thrombogenesis was present and the entire cross sections of blood vessels could easily be embolized. Neither acute and chronic inflammatory cells nor remarkable general toxic and side effects were shown in rabbits.


CONCLUSIONS
Domestic HMs can effectively block the vessels, and they have the characteristics of good biocompatibility. The kind of domestic HMs is a promising particulate embolic agent in clinical sets.
Li
T
T
Department of Neurosurgery, Zhujiang Hospital, First Military Medical University, Guangzhou 510282.
Wang
Q
Q
Ling
F
F
Lu
Z
Z
Duan
C
C
Wang
X
X
D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects / Q000627:therapeutic use; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D005260:Female; D020100:Hydrogels / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008863:Microspheres; D009422:Nervous System Diseases / Q000209:etiology; D011817:Rabbits
D001672:Biocompatible Materials; D020100:Hydrogels