title: [A search for chromosome 13 QTL in a complex pig family].
abstract: A search for chromosome 13 QTL was carried out in a pig family of complex pedigree. The results indicated that a significant QTL on chromosome 13 was segregating in pig family. The QTL significantly affected body weight and average daily gain (P < 0.05), but the effect on backfat thickness was not significant (P > 0.05). Interval mapping localized this QTL between SW1898 and SW398. The estimated linkage position of this QTL was 75.2 cM. The QTL variance estimated at the marker interval was 0.9037 for the body weight and 0.0010 for average daily gain, respectively. This was the region which flanked the PIT1 gene, an essential transcriptional regulatory factor of growth hormone, prolactin and thyrotropin beta subunit. The present result confirmed a previous suggestion of a QTL for early growth traits at the estimated PIT1 position, and further implied that the effect of PIT1 genes on growth and body weight remained for the whole period of individual growth and development. Aditional evidence was also found which suggested a backfat QTL on chromosome 13, at a location approximately 28.3-63.4 cM apart from the one for body weight and growth, but the level of significance was not consistent in different generations.
authors.affiliation: Lab of Molecular Biology, Hunan Institute of Animal & Veterinary Science, Changsha 410131, China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Wu
authors.forename: Qi-Shun
authors.initials: QS
authors.lastname: Shi
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Liu
authors.forename: Ying-Lin
authors.initials: YL
authors.lastname: Peng
authors.forename: Juan
authors.initials: J
authors.lastname: Jiang
authors.forename: Shi-Liu
authors.initials: SL
authors.lastname: Yang
authors.forename: Bing-Nan
authors.initials: BN
authors.lastname: Xiao
mesh_terms: D000818:Animals; D001835:Body Weight / Q000235:genetics*; D002874:Chromosome Mapping; D002875:Chromosomes; D018895:Microsatellite Repeats / Q000235:genetics*; D008957:Models, Genetic; D010375:Pedigree; D019655:Quantitative Trait, Heritable; D013552:Swine / Q000235:genetics*; D015430:Weight Gain / Q000235:genetics