Molecular linkage studies of bipolar disorders.
OBJECTIVE
To review the reports of linkage findings for bipolar disorder.


METHODS
Literature review of published linkage findings in bipolar disorder.


RESULTS
There are several regions of the human genome that have been implicated repeatedly by independent investigators. These include 4p16, 12q24, 18q22, 18p11, 21q21 and 22q11. Two of these regions (18p11 and 22q11) are also implicated in genome scans of schizophrenia, suggesting that these two distinct nosological categories may share some genetic susceptibility. This hypothesis can only be tested when the underlying genes are identified.
Berrettini
W H
WH
Department of Psychiatry and the Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19107, USA. wadeb@mail.med.upenn.edu
D001714:Bipolar Disorder / Q000235:genetics*; D005787:Gene Frequency; D008040:Genetic Linkage; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D011110:Polymorphism, Genetic / Q000235:genetics