Rat genetics: attaching physiology and pharmacology to the genome.
During the past five years, the Rat Genome Project has been rapidly gaining momentum, especially since the announcement in August 2000 of plans to sequence the rat genome. Combined with the wealth of physiological and pharmacological data for the rat, the genome sequence should facilitate the discovery of mammalian genes that underlie the physiological pathways that are involved in disease. Most importantly, this combined physiological and genomic information should also lead to the development of better pre-clinical models of human disease, which will aid in the development of new therapeutics.
Jacob
Howard J
HJ
Department of Physiology, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA. jacob@mcw.edu
Kwitek
Anne E
AE
D000818:Animals; D004195:Disease Models, Animal; D016678:Genome; D006801:Humans; D010600:Pharmacology; D010827:Physiology; D019655:Quantitative Trait, Heritable; D051381:Rats / Q000235:genetics*