Caenorhabditis elegans as a host for the study of host-pathogen interactions.
Recently, pathogenicity models that involve the killing of the genetically tractable nematode Caenorhabditis elegans by human pathogens have been developed. From the perspective of the pathogen, the advantage of these models is that thousands of mutagenized bacterial clones can be individually screened for avirulent mutants on separate petri plates seeded with C. elegans. The advantages of using C. elegans to study host responses to pathogen attack are the extensive genetic and genomic resources available and the relative ease of identifying C. elegans mutants that exhibit altered susceptibility to pathogen attack. The use of Caenorhabditis elegans as the host for a variety of human pathogens is discussed.
Aballay
Alejandro
A
Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA. aballay@molbio.mgh.harvard.edu
Ausubel
Frederick M
FM
D000192:Actinomycetales / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology*; D000818:Animals; D001424:Bacterial Infections / Q000503:physiopathology*; D001426:Bacterial Proteins / Q000276:immunology* / Q000494:pharmacology / Q000633:toxicity; D017173:Caenorhabditis elegans / Q000469:parasitology / Q000502:physiology*; D015870:Gene Expression; D016908:Gram-Positive Bacterial Infections / Q000276:immunology; D006790:Host-Parasite Interactions / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D016254:Mutagenesis, Insertional / Q000276:immunology*; D011550:Pseudomonas aeruginosa / Q000378:metabolism* / Q000472:pathogenicity; D015398:Signal Transduction; D014774:Virulence
D001426:Bacterial Proteins