title: The treatment of Lewisite burns with laser debridement---'lasablation'.
abstract: Lewisite (dichloro (2-chlorovinyl) arsine) was first synthesised in 1918 and its potential for use in military confrontations as a vesicant agent has been widely recognised. These agents cause blistering skin reactions with resultant full thickness burns. Effective treatments to date have been delayed by the lack of suitable animal models. Porcine skin has recently been used successfully to model the development and natural history of these burn injuries. A large white pig model (n=6) was employed to investigate the effectiveness of CO(2) and Erbium-YAG lasers (EYL) in laser dermabrasion of established Lewisite burns. Burns underwent treatment at 4 days post-exposure and were assessed at 1, 2 and 3 weeks, thereafter, for the rate of epithelial healing. The re-epithelialisation rates in the laser dermabraded groups were accelerated by a factor of four compared to untreated controls by the first week (analysis of vartiance, ANOVA, P=0.006 for pulsed CO(2) and P=0.011 for Erbium-YAG). Ablation of the burn eschar was thought to accelerate the rate of healing by causing partial debridement. This method has been termed 'lasablation' and represents a significant advance in the clinical management of this type of injury.
authors.affiliation: Biomedical Sciences Department, Dstl Chemical and Biological Sciences, Porton Down, Wiltshire SP4 0JQ, Salisbury, UK.
authors.forename: D G K
authors.initials: DG
authors.lastname: Lam
authors.forename: P
authors.initials: P
authors.lastname: Rice
authors.forename: R F R
authors.initials: RF
authors.lastname: Brown
mesh_terms: D000818:Animals; D001152:Arsenicals / Q000009:adverse effects*; D002057:Burns, Chemical / Q000503:physiopathology / Q000601:surgery*; D003646:Debridement / Q000379:methods*; D003869:Dermabrasion / Q000379:methods*; D004195:Disease Models, Animal; D004848:Epithelium / Q000503:physiopathology; D053685:Laser Therapy; D013552:Swine; D014945:Wound Healing / Q000502:physiology
chemical_list: D001152:Arsenicals; C035965:lewisite