title: [Bacterial meningitis in Yaoundé (Cameroon) in 1999-2000].
abstract: All cephalo-spinal fluid (CSF) samples sent to the Yaoundé Pasteur Centre in Cameroon, between July 1999 and June 2000, were cultured and tested for soluble antigens. The percentage of positive samples was 10.4%. The main etiological agents detected were Streptococcus pneumoniae (56.2%), Haemophilus influenzae (18.5%) et Neisseria meningitidis (13.4%). Most of these cases of bacterial meningitis were children (86.7%). The susceptibility of the isolates to antibiotics was investigated. The streptococci and meningococci were mostly susceptible to beta-lactams, but the Gram-negative bacteria were not. Combinations of amino-penicillin and aminoside or chloramphenicol continue to be effective, as are third generation cephalosporins used alone. Meningococci appear to have emerged during the year 1999/2000, with 23 such isolates identified, of which 17 were serogroup A, subtype P1-9, clone III-1, which was responsible for the second pandemic. It should also be noted that 4 strains of N. meningitidis of serogroup W135 were isolated in Yaoundé.
authors.affiliation: Laboratoire de bactériologie, Centre Pasteur du Cameroun, BP 1274 Yaoundé, Cameroun.
authors.forename: M C
authors.initials: MC
authors.lastname: Fonkoua
authors.forename: P
authors.initials: P
authors.lastname: Cunin
authors.forename: P
authors.initials: P
authors.lastname: Sorlin
authors.forename: J
authors.initials: J
authors.lastname: Musi
authors.forename: P M
authors.initials: PM
authors.lastname: Martin
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000942:Antigens, Bacterial / Q000134:cerebrospinal fluid; D002163:Cameroon / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D006193:Haemophilus influenzae; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016920:Meningitis, Bacterial / Q000453:epidemiology* / Q000382:microbiology; D008583:Meningitis, Haemophilus / Q000453:epidemiology / Q000382:microbiology; D008585:Meningitis, Meningococcal / Q000453:epidemiology / Q000382:microbiology; D008586:Meningitis, Pneumococcal / Q000453:epidemiology / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial