title: [Wound botulism after drug injection].
abstract: METHODS
  A 32-year old male drug user presented with diplopia, ataxia and general weakness. The patient had abscesses on arms and legs at injection sites, bilateral ptosis, a bifacial weakness, nasal speech, severely reduced ability to raise his arms and a positive Trendelelenburg sign with normal motor neuron reflexes and normal sensation.
  
  
  METHODS
  The haematological values indicated a hypochromic, microcytic anaemia (12,1 mg/dl), a slight leuko (10,8 G/L) - and thrombocytosis (582G/l) with elevated erythrocyte sedimentation rate (74 mm/h), and a reduced prothrombin time (67%). The HIV test was negative. The MRI scan of the brain and the bacterial, serological and cytological results of a lumbar puncture were normal. In the bloodculture no bacterial growth and no botulinum toxin was found. In a culture of the wound material grew coagulase-negative staphylococcus and Clostridium perfringens, diagnosed with PCR. The serum anti-acethylcholine antibodies were negative. The motor-nerve conduction test with repetitive stimulation of the ulnari nerve with a 3 Hz trigger showed no change in the amplitude, while a 20 Hz trigger showed an increment up to 160 %.
  Another possible diagnosis was excluded through MRI, CSF and serum examination. The typical presentation of a rapidly progressive descending paralysis without loss of sensation and the typical motor-nerve conduction disorder of a presynaptic block established the diagnosis of wound botulism. This was treated immediately by surgical removal of wound debris, antitoxin- and penicillin therapy. After 28 days the patient left the hospital with slight residual problems. He had been admitted to the intensive care unit for a short period only and intubation was not necessary at any time.
  
  
  CONCLUSIONS
  After exclusion of any other possible diagnosis, it is possible to establish an early diagnosis of injection related wound botulism by its typical symptoms and signs. These are presented as wound abcesses at intramuscular drug injection sites together with rapidly progressive descending paralysis with preserved sensation. Treatment consists of surgical excision of wound debris combined with antitoxin and penicillin administration in order to prevent a possible build-up of residues. Early diagnosis and associated therapy overcome the necessity of intubation and prolonged intensive care.
authors.affiliation: Kantonsspital Luzern, Schweiz, Germany. Friedrich.Scheibe@Spital-muri.ch
authors.forename: F
authors.initials: F
authors.lastname: Scheibe
authors.forename: B
authors.initials: B
authors.lastname: Hug
authors.forename: M
authors.initials: M
authors.lastname: Rossi
mesh_terms: D000328:Adult; D001904:Botulinum Antitoxin / Q000627:therapeutic use; D001906:Botulism / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003937:Diagnosis, Differential; D003932:Heroin / Q000008:administration & dosage*; D006556:Heroin Dependence / Q000150:complications*; D006801:Humans; D007273:Injections, Intramuscular / Q000009:adverse effects*; D007275:Injections, Intravenous; D008297:Male; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D014946:Wound Infection / Q000175:diagnosis
chemical_list: D001904:Botulinum Antitoxin; D010406:Penicillins; D003932:Heroin