Marginal utility of montelukast for persistent asthma.
BACKGROUND
The efficacy of a new pharmacologic agent for asthma, in this instance the leukotriene receptor antagonist montelukast, is determined in controlled trials in research subjects. The utility of a new drug is determined by multiple uncontrollable factors in individual patients.


OBJECTIVE
To assess the utility of montelukast in the management of persistent asthma.


METHODS
Observational, retrospective.


METHODS
Suburban multispecialty medical clinic.


METHODS
From April 1998, montelukast was prescribed for 110 patients with persistent but controlled asthma, primarily for the corticosteroid-sparing effect. Outcomes after 1 year were determined from audits of medical records and responses to questionnaires.


RESULTS
At least 56% of patients continued receiving montelukast for the entire year. However, compared to those patients who had discontinued montelukast therapy, those who continued receiving it had no difference in the use of inhaled or systemic corticosteroid or inhaled beta(2)-agonist therapy.


CONCLUSIONS
Montelukast had marginal utility in the management of these adult patients with controlled persistent asthma.
Mathison
David A
DA
Division of Allergy, Asthma and Immunology, Scripps Clinic, La Jolla, CA 92037, USA. dmathison@scrippsclinic.com
Koziol
James A
JA
D000085:Acetates / Q000627:therapeutic use*; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D003521:Cyclopropanes; D006801:Humans; D020024:Leukotriene Antagonists; D008875:Middle Aged; D011804:Quinolines / Q000627:therapeutic use*; D012189:Retrospective Studies; D013440:Sulfides; D016896:Treatment Outcome
D000085:Acetates; D000305:Adrenal Cortex Hormones; D000318:Adrenergic beta-Agonists; D018927:Anti-Asthmatic Agents; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast