[Intestinal blood perfusion improved by early enteral feeding in burned rat].
OBJECTIVE
To explore the mechanism of intestinal blood perfusion improved by early enteral feeding after burn injury.


METHODS
Wistar rats were inflicted with 30% total body surface area full thickness flame burn and randomly divided into three groups: burned control (B), burned and early feeding (EF), and normal control (C). The content of endothelin (ET), nitric oxide (NO), vasoactive intestinal peptide (VIP), and intestine mucosal blood flow (IMBF) were determined at postburn 0, 3, 6, 12, 24, 48 hours.


RESULTS
The content of ET, NO, VIP in small intestine as well as the ratio of ET/NO, ET/VIP were increased significantly and the IMBF was decreased markedly postburn. In EF group, ET, ET/NO and ET/VIP were significantly lower (P < 0.05, P < 0.01), and NO, VIP as well as IMBF were higher than those in B group (P < 0.05, P < 0.01). There were negative correlation between ET/NO, ET/VIP and IMBF (r(1) = -0.95, P < 0.01; r(2) = -0.87, P < 0.01).


CONCLUSIONS
The mechanism of intestinal blood perfusion improved by early enteral feeding may be correlated with increased NO, VIP and decreased ET induced by foods stimulating intestinal nerve.
Peng
X
X
Institute of Burn Research, Southwest Hospital, Chongqing 400038.
Wang
S
S
Feng
J
J
You
Z
Z
Wang
P
P
Li
A
A
D000818:Animals; D002056:Burns / Q000503:physiopathology*; D016232:Endothelins / Q000378:metabolism; D004750:Enteral Nutrition; D005260:Female; D007413:Intestinal Mucosa / Q000098:blood supply*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow; D013997:Time Factors; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
D016232:Endothelins; D009569:Nitric Oxide; D014660:Vasoactive Intestinal Peptide