Adapalene gel 0.1%: effective and well tolerated in the topical treatment of acne vulgaris in Chinese patients.
Acne vulgaris is a common dermatologic disease in Asian populations, as well as in Caucasians. Our objective was to evaluate the safety and efficacy of adapalene gel 0.1% in comparison with tretinoin gel 0.025% in Chinese patients with acne vulgaris. We used an 8-week, multicenter, randomized, controlled, investigator-masked, parallel group design study of adapalene gel 0.1% and tretinoin gel 0.025% in 150 Chinese patients with mild-to-moderate acne vulgaris. Our results showed that adapalene gel 0.1% had efficacy equivalent to tretinoin gel 0.025% against acne lesions in Chinese patients, with a more acceptable tolerability profile.
Zhu
X J
XJ
Department of Dermatology, Peking University First Hospital, Beijing, People's Republic of China.
Tu
P
P
Zhen
J
J
Duan
Y Q
YQ
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000208:ethnology; D000068816:Adapalene; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002681:China; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use; D008297:Male; D009281:Naphthalenes / Q000627:therapeutic use*; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014212:Tretinoin / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007641:Keratolytic Agents; D009281:Naphthalenes; D000068816:Adapalene; D014212:Tretinoin