title: PROGINS receptor gene polymorphism is associated with endometriosis.
abstract: OBJECTIVE
  To investigate the association between the 306-base pair insertion polymorphism in intron G of the progesterone receptor (PROGINS) and endometriosis.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Tertiary care center.
  
  
  METHODS
  Ninety-five white women with surgically diagnosed and histologically confirmed endometriosis and 107 white women without endometriosis (controls).
  
  
  METHODS
  Determination of PROGINS was performed by polymerase chain reaction and gel electrophoresis. MAIN OUTCOIME MEASURE(S): Frequency and distribution of the PROGINS allele.
  
  
  RESULTS
  Frequencies of the mutant allele T2 was 0.17 among women with endometriosis and 0.08 among controls (odds ratio, 2.41 [CI, 1.31-4.53]). Homozygosity for allele T2 was present in 3.2% of women with endometriosis and 0.9% of controls.
  
  
  CONCLUSIONS
  PROGINS appears to be associated with endometriosis in white persons.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, University of Vienna, Waeringer Guertel 18-20, A-1090 Vienna, Austria.
authors.forename: Fritz
authors.initials: F
authors.lastname: Wieser
authors.forename: Christian
authors.initials: C
authors.lastname: Schneeberger
authors.forename: Dan
authors.initials: D
authors.lastname: Tong
authors.forename: Clemens
authors.initials: C
authors.lastname: Tempfer
authors.forename: Johannes C
authors.initials: JC
authors.lastname: Huber
authors.forename: Rene
authors.initials: R
authors.lastname: Wenzl
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004247:DNA / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D004587:Electrophoresis, Agar Gel; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics*; D018709:Statistics, Nonparametric
chemical_list: D011980:Receptors, Progesterone; D004247:DNA