Recent advances in the physiology of whole body immersion.
Recent investigations have furnished a complete analysis of the hemodynamic events accompanying whole-body immersion. About 700 ml of blood are translocated into the intrathoracic circulation, and heart volume increases by 180 +/- 62 ml. These changes are followed by an increase in stroke volume and cardiac output of over 30%. At the same time a reflex reduction of total peripheral resistance and venous tone occurs. Renin and aldosterone activity are reduced while the 17-hydroxycorticosteroid is not affected. Treatment of the subject with DOCA attenuates but does not extinguish the excess sodium excretion of immersion. This finding strengthens the arguments in favor of an unknown factor enhancing sodium excretion. Finally, the relative activation of the three factors that serve volume control, the excretory function of the kidney, capillary filtration pressure, and the thirst mechanism, is discussed.
Gauer
O H
OH
Physiologisches Institut der Freien Universitat Berlin, Berlin, Germany.
D015065:17-Hydroxycorticosteroids / Q000097:blood / Q000378:metabolism; D000450:Aldosterone / Q000097:blood / Q000378:metabolism; D001810:Blood Volume / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D002306:Cardiac Volume / Q000502:physiology; D003900:Desoxycorticosterone / Q000494:pharmacology; D005110:Extracellular Space / Q000378:metabolism / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007101:Immersion; D007668:Kidney / Q000187:drug effects; D010953:Plasma Volume / Q000502:physiology*; D012083:Renin / Q000097:blood / Q000378:metabolism; D012964:Sodium / Q000378:metabolism* / Q000652:urine; D013318:Stroke Volume / Q000502:physiology; D013894:Thirst / Q000502:physiology; D018474:Weightlessness Simulation
D015065:17-Hydroxycorticosteroids; D003900:Desoxycorticosterone; D000450:Aldosterone; D012964:Sodium; D012083:Renin