Ricardo Miledi and the calcium hypothesis of neurotransmitter release.
Ricardo Miledi has made significant contributions to our basic understanding of how synapses work. Here I discuss aspects of Miledi's research that helped to establish the requirement of presynaptic calcium for neurotransmitter release, from his earliest scientific studies to his classic experiments in the squid giant synapse.
Jeng
Jade-Ming
JM
Department of Neurobiology and Behavior, University of California, Irvine 92697-4292, USA. jengj@uci.edu
D000818:Animals; D001369:Axons / Q000502:physiology; D002118:Calcium / Q000266:history* / Q000378:metabolism; D049832:Decapodiformes; D049673:History, 20th Century; D008800:Mexico; D009469:Neuromuscular Junction / Q000502:physiology; D009482:Neurophysiology / Q000266:history; D018377:Neurotransmitter Agents / Q000266:history* / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*; D014481:United States
D018377:Neurotransmitter Agents; D002118:Calcium