Effect of low-dose irradiation on induction of an apoptotic adaptive response in the murine system.
The aim of the study was to investigate the effect of low doses of irradiation on the induction of an apoptotic adaptive response in the murine system using C3H/HeJ mice bearing 8 mm syngeneic tumors, HCa-I and OCa-I. In OCa-I, the 0.05 Gy priming dose significantly reduced the 25 Gy-induced apoptosis by 30%, whereas this reduction was not seen in HCa-I. The analysis of apoptosis-regulating molecules showed that the application of a priming dose increased the radiation-induced p53 level in both tumors. No other regulators changed in OCa-I. However, in HCa-I, the application of a priming dose increased radiation-induced Bcl-XL and Bcl-XS, but not Bcl-2 or Bax. An apoptotic adaptive response induced by low-dose radiation was shown in one murine tumor, OCa-I and Bcl-XL and Bcl-XS appeared to be implicated.
Seong
J
J
Department of Radiation Oncology, Yonsei University Medical College, Seoul, Korea. jsseong@yumc.yonsei.ac.kr
Kim
S H
SH
Pyo
H R
HR
Chung
E J
EJ
Suh
C O
CO
D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D015153:Blotting, Western; D053938:DNA Fragmentation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D014407:Tumor Cells, Cultured