Sensitization to p-phenylenediamine.
p-Phenylenediamine (PPD) from 0.2 mg to 1.6 mg in water or in petrolatum was applied as a patch test to 501 patients with different dermatoses, asthma, hay fever, and venereal diseases. Of these patients 10.6% reacted within the first five days indicating previous hypersensitivity and 14.4% between the sixth and the 16th day indicating the initiation of hypersensitivity to PPD by the patch application (flare-up). The reactions within the first five days were not correlated with the amount of PPD in the tests, but a statistically significant correlation was found between flare-ups and amount, so that the larger the amount of PPD the higher the frequency of flare-ups. About one half of both reactions occurred in patients with eczematous dermatitis.
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National Institute of Public Health, Department of Dermatology, Karolinska Sjukhuset, Stockholm, Sweden.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004396:Coloring Agents; D003877:Dermatitis, Contact / Q000209:etiology; D006801:Humans; D007114:Immunization; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods; D010655:Phenylenediamines / Q000276:immunology*
D004396:Coloring Agents; D010655:Phenylenediamines; C029728:4-phenylenediamine