title: Delirium after interleukin-2 and alpha-interferon therapy for renal cell carcinoma.
abstract: A 55-year-old man receiving alpha-interferon and interleukin-2 therapy for renal cell carcinoma presented with seizures and delirium. A CT-scan of the cerebrum did not reveal any disorder. Both alpha-interferon and interleukin-2 were stopped. Treatment with steroids led to complete regression of central nervous system symptomatology. We emphasize the importance of ruling out iatrogenesis in patients treated with alpha-interferon and/or interleukin-2 who display neuropsychiatric symptoms.
authors.affiliation: Department of Medical Oncology, University Hospital Groningen, The Netherlands. j.h.m.van.steijn@int.azg.nl
authors.forename: J H
authors.initials: JH
authors.lastname: van Steijn
authors.forename: P
authors.initials: P
authors.lastname: Nieboer
authors.forename: G A
authors.initials: GA
authors.lastname: Hospers
authors.forename: E G
authors.initials: EG
authors.lastname: de Vries
authors.forename: N H
authors.initials: NH
authors.lastname: Mulder
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D003693:Delirium / Q000139:chemically induced*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged