Inoculation of chicks with viable non-colonizing strains of Campylobacter jejuni: evaluation of protection against a colonizing strain.
We have treated chicks with viable non-colonizing mutant strains of Campylobacter jejuni to test these as a possible vaccine. We found that intramuscular inoculation with and without adjuvant, and with or without a concomitant oral dose of non-colonizing strains, failed to provoke protective immunity.
Ziprin
Richard L
RL
Food and Feed Safety Research Unit, Southern Plains Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, 2881 F&B Road, College Station, TX 77845, USA. ziprin@ffsru.tamu.edu
Hume
Michael E
ME
Young
Colin R
CR
Harvey
Roger B
RB
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage; D016123:Campylobacter jejuni / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity*; D002645:Chickens / Q000276:immunology* / Q000382:microbiology*; D004064:Digestive System / Q000276:immunology / Q000382:microbiology; D005516:Food Microbiology; D005798:Genes, Bacterial; D007273:Injections, Intramuscular; D009154:Mutation; D014774:Virulence / Q000235:genetics
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines