[Effects of serum and decidual tissue fluid in early pregnant women on natural killer cells activity and lymphocyte proliferation].
OBJECTIVE
To study the effects of serum and decidual tissue fluid in early pregnant women on natural killer cells (NK cells) activity and lymphocyte proliferation.


METHODS
The effects of the serum and decidual tissue fluid obtained from 32 normal early pregnant women on NK cells activity and lymphocyte proliferation were tested by isotope incorporation methods. Sera of 25 nonpregnant women were chosen as controls.


RESULTS
The NK cells activity and lymphocyte proliferation of sera and decidual tissue fluids from early pregnant women were lower than those of sera from nonpregnant women (P < 0.01). So were those of decidual tissue fluid as compared with sera during early pregnancy (P < 0.005).


CONCLUSIONS
Serum and decidual tissue fluid from early pregnant women expressed immunosuppressive effects. It is possible that these effects of decidual tissue fluid play an important role in regulating local immune status of pregnant uterus.
Zhou
L
L
Department of Obstetrics and Gynecology, General Hospital of Guangzhou Command, Guangzhou 510010, China.
Huang
L
L
Yang
B
B
D000328:Adult; D002455:Cell Division / Q000276:immunology; D003656:Decidua / Q000166:cytology / Q000276:immunology*; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D011247:Pregnancy / Q000276:immunology*; D011261:Pregnancy Trimester, First