Five new nortropane alkaloids and six new amino acids from the fruit of Morus alba LINNE growing in Turkey.
Investigation of the constituents of the fruits of Morus alba LINNE (Moraceae) afforded five new nortropane alkaloids (1-5) along with nor-psi-tropine (6) and six new amino acids, morusimic acids A-F (7-12). The structures of the new compounds were determined to be 2alpha,3beta-dihydroxynortropane (1), 2beta,3beta-dihydroxynortropane (2), 2alpha,3beta,6exo-trihydroxynortropane (3), 2alpha,3beta,4alpha-rihydroxynortropane (4), 3beta,6exo-dihydroxynortropane (5), (3R)-3-hydroxy-12-[(1S,4S)-4-[(1S)-1-hydroxyethyl]-pyrrolidin-1-yll-dodecanoic acid-3-O-beta-D-glucopyranoside (7), (3R)-3-hydroxy-12-[(1S,4S)-4-[(1S)-1-hydroxyethyl]-pyrrolidin-1-yll-dodecanoic acid (8), (3R)-3-hydroxy-12-1(1R,4R,5S)-4-hydroxy-5-methyl-piperidin-1-yll-dodecanoic acid-3-O-beta-D-glucopyranoside (9), (3R)-3-hydroxy-12-[(1R,4R,5S)-4-hydroxy-5-methyl-piperidin-1-yll-dodecanoic acid (10), (3R)-3-hydroxy-12-[(1R,4R,5S)-4-hydroxy-5-hydroxymethyl-piperidin-1-yl]-dodecanoic acid-3-O-beta-D-glucopyranoside (11), and (3R)-3-hydroxy-12-[(1R,4S,5S)-4-hydroxy-5-methyl-piperidin-1-yl]-dodecanoic acid (12) on the basis of spectral and chemical data.
Kusano
Genjirou
G
Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan. kusano@gly.oups.ac.jp
Orihara
Shiho
S
Tsukamoto
Daisuke
D
Shibano
Makio
M
Coskun
Maksut
M
Guvenc
Aysegul
A
Erdurak
Ceyda Sibel
CS
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000596:Amino Acids / Q000737:chemistry / Q000302:isolation & purification*; D005638:Fruit; D009682:Magnetic Resonance Spectroscopy; D029586:Moraceae / Q000737:chemistry*; D014421:Turkey
D000470:Alkaloids; D000596:Amino Acids