Effects of thyroid hormones on inner mitochondrial membrane fluidity.
Authors studied the effects of thyroid hormones and their diasteroisomers and 3,5-diiodothyronine (LT2) on the fluidity properties of inner mitochondrial membrane (IMM) by specifical fluorescent probe for the internal zone of biological membranes, the 1,6-diphenyl-1,3,5-hexatriene (DPH). The studied parameters are Arrhenius and Perrin plots. The DPH shows a decreased fluorescence quenching in the presence of both T3 and T4. The maximum effect is observed with 2 nM LT2. LT2 is more effective than LT3 in the central zone. The data confirm the selective action of LT3 and LT4 on IMM fluidity.
Chimenti
R
R
Department of Cell Biology, University of Calabria, Rende.
Covello
C
C
De Cicco
T
T
Bruno
R
R
Martino
G
G
D000818:Animals; D004104:Diiodothyronines / Q000378:metabolism* / Q000494:pharmacology; D007425:Intracellular Membranes / Q000187:drug effects; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects / Q000502:physiology*; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000378:metabolism* / Q000494:pharmacology; D014284:Triiodothyronine / Q000378:metabolism* / Q000494:pharmacology
D004104:Diiodothyronines; D014284:Triiodothyronine; D013974:Thyroxine