Weaning success among ventilator-dependent patients in a rehabilitation facility.
OBJECTIVE
To determine outcomes of difficult-to-wean, ventilator-dependent patients transferred from intensive care units to rehabilitation hospitals and to determine predictors of weaning success in such patients.


METHODS
A retrospective cohort study.


METHODS
A rehabilitation facility.


METHODS
One hundred forty-five difficult-to-wean patients (55.2% men; 83.4% white; mean age +/- standard deviation, 65.8 +/- 16.4y) transferred to a rehabilitation facility between July 1994 and June 1996.


METHODS
Not applicable.


METHODS
Demographic and clinical data, including variables identified previously as predictive of weaning success among highly selected populations.


RESULTS
Patients' Gillespie categories (reason for ventilator dependency) included "other medical conditions" (eg, pneumonia, neurologic) in 42.1% of the cases, postoperative in 24.8%, previous lung disease (eg, chronic obstructive pulmonary disease, interstitial lung disease) in 15.2%, trauma in 11.7%, respiratory failure with multisystem failure in 3.4%, and uncomplicated acute lung injury (acute respiratory distress syndrome) in 2.8%. Of 145 patients, 50.3% were completely weaned, 4.8% were partially weaned, and 44.8% remained ventilator dependent. In a stepwise multivariable logistic regression analysis, significant predictors of weaning success included white race (odds ratio [OR] = 3.4), serum albumin level (OR = 2.1g/dL), and blood urea nitrogen (BUN) level (OR = .97mg/dL); in addition, compared with postoperative patients, patients with "other medical conditions" (OR = .15) or previous lung disease (OR = .08) were less likely to be weaned (area under receiver operating characteristic curve = .76). Among 31 long-term survivors who were interviewed at least 6 months after discharge from the rehabilitation facility, 58.1% rated their health-related quality of life as good or better.


CONCLUSIONS
Half of the patients admitted to a rehabilitation facility were weaned from their ventilators. Predictors of weaning success included race, BUN level, albumin level, and reason for ventilator dependency.
Modawal
Arvind
A
Section of Geriatric Medicine, Department of Family Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267-0535, USA.
Candadai
Niranjana P
NP
Mandell
Karen M
KM
Moore
Eileen S
ES
Hornung
Richard W
RW
Ho
Mona L
ML
Tsevat
Joel
J
D000368:Aged; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009820:Ohio; D017063:Outcome Assessment, Health Care; D010360:Patient Transfer; D012047:Rehabilitation Centers; D012189:Retrospective Studies; D012306:Risk; D015300:Ventilator Weaning