Protective effect of ischemic preconditioning on liver.
OBJECTIVE
To study the protective effect of ischemic preconditioning (IPC) on the hepatic ischemia reperfusion injury.


METHODS
The model of rat liver subjected to ischemia/reperfusion (I/R) injury was made. All 24 mice were divided randomly into 3 groups and anesthetized by 2% sodium pentobarbital (30-40 mg/kg). The enzyme activity of AST, ALT, LDH, SOD and the content of LPO were assayed respectively. Specimens were observed under transmission electron microscope.


RESULTS
IPC prevented the increase of ALT, AST and LDH in the blood and that of LPO in the tissues (P<0.05), and maintained high level of SOD in the tissues (P<0.05).


CONCLUSIONS
IPC has protective effect on the liver function.
Zhang
Y
Y
Vascular Surgery, Affiliated Renji Hospital, Shanghai Second Medical University, Shanghai, 200001, China.
Zhang
B
B
Pan
R
R
D000818:Animals; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology; D019194:Ischemic Preconditioning; D008099:Liver / Q000098:blood supply* / Q000473:pathology*; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*