Tricorn-like proteases in bacteria.
The tricorn protease is an archaeal protease that forms massive proteasome-like capsids with a hollow chamber. beta-Propeller and PDZ domains are thought to play a role in substrate selection. By analysis of predicted proteins from novel bacterial genome sequences, we have identified four new bacterial tricorn-like proteases, complete with similar beta-propeller, PDZ and catalytic domains. We propose various hypotheses as to the function of these domains that can now be tested in the laboratory.
Pallen
M J
MJ
Microbial Genomics and Pathogenesis Unit, Division of Immunity and Infection, The Medical School, University of Birmingham, B15 2TT., Birmingham, UK. m.pallen@bham.ac.uk
Lam
A C
AC
Loman
N
N
D000595:Amino Acid Sequence; D001419:Bacteria / Q000201:enzymology*; D020134:Catalytic Domain / Q000235:genetics; D010450:Endopeptidases / Q000032:analysis / Q000235:genetics*; D017434:Protein Structure, Tertiary / Q000235:genetics*; D020539:Sequence Analysis, Protein; D017385:Sequence Homology
D010450:Endopeptidases; C102094:tricorn protease