[Modulation of calcium conductance by opioid and anti-opioid peptides].
In the central nervous system, opening of voltage-gated Ca2+ channels triggers the release of neurotransmitters. Numerous membrane receptors, particularly those belonging to the superfamily of G-protein coupled receptors modulate, in most cases inhibit the activity of these channels. In the present review, we describe the modulation of calcium channels by opioid and anti-opioid peptides. Following a brief presentation of the opioid system, we describe the characteristics of the modulation of calcium channels by opioids. Recent major advances concerning neuropeptide FF (NPFF), taken as an example of anti-opioid systems, are reviewed. Results from our laboratory demonstrating the anti-opioid activity of NPFF, in the modulation of Ca2+ channels in isolated neurones, are described.
Roumy
M
M
Institut de Pharmacologie et de Biologie Structurale, C.N.R.S. UMR 5089, 205 Route de Narbonne, 31077 Toulouse, France.
Zajac
J M
JM
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects* / Q000502:physiology*; D004553:Electric Conductivity; D006801:Humans; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009842:Oligopeptides; D018847:Opioid Peptides / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000502:physiology
D015220:Calcium Channels; D009292:Narcotic Antagonists; D009842:Oligopeptides; D018847:Opioid Peptides; D011957:Receptors, Opioid; C053651:phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide