Antipruritic effects of 1,4-naphthoquinones and related compounds.
The antipruritic effects of orally administered 1,4-naphthoquinone derivatives and related compounds on compound 48/80-induced scratching behavior in mice were studied. 2-Hydroxy-3-(2-hydroxyethyl)-1,4-naphthoquinone, ferulic acid, 2,2'-methylenebis(3-hydroxy-1,4-naphthoquinone), and 2,2'-ethylidenebis(3-hydroxy-1,4-naphthoquinone) (impatienol) all exhibited significant antipruritic activity. However, 2-methoxy-3-(2-hydroxyethyl)-1,4-naphthoquinone (balsaquinone), which was isolated from a natural source for the first time, did not show any activity. The present results indicate that these compounds are promising for treating allergic diseases with chronic and severe pruritus.
Oku
Hisae
H
Mukogawa Women's University, School of Pharmaceutical Sciences, Nishinomiya, Japan.
Kato
Toyonari
T
Ishiguro
Kyoko
K
D000818:Animals; D000982:Antipruritics; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011537:Pruritus / Q000139:chemically induced / Q000517:prevention & control*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D003189:p-Methoxy-N-methylphenethylamine
D000982:Antipruritics; D009285:Naphthoquinones; D003189:p-Methoxy-N-methylphenethylamine