[3,5-Dinitrobenzoic acid anhydride as reagent for the characterization of drugs and for the activation of polarographically inactive compounds].
Drugs with primary or secondary amino groups react with 3,5-dinitrobenzoic acid anhydride under catalysis of pyridine derivatives almost quantitatively to yield the corresponding amides which are reducible at the dropping mercury electrode (DME). 3,5-Dinitrobenzoic acid will be separated by thin layer chromatography. The limit of detection by DPP is in the range of 10(-8) M. The electrode reaction is irreversible.
Köhler
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W
Institut für Pharmazie der Friedrich-Schiller-Universität, Jena, Germany.
Oelschläger
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H
D000812:Anhydrides; D002384:Catalysis; D002855:Chromatography, Thin Layer; D004566:Electrodes; D007202:Indicators and Reagents; D008628:Mercury; D009579:Nitrobenzoates / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011048:Polarography; D011725:Pyridines / Q000737:chemistry
D000812:Anhydrides; D007202:Indicators and Reagents; D009579:Nitrobenzoates; D004364:Pharmaceutical Preparations; D011725:Pyridines; C026017:3,5-dinitrobenzoic acid; D008628:Mercury