[Vascular endothelial factor of meningomas and peritumoural vasogenic brain edema].
OBJECTIVE
To study the expression of vascular endothelial growth factor (VEGF) in meningomas correlated with peritumoral vasogenic brain edema (PVBE) and angiogenesis.


METHODS
VEGF protein expression in 33 patients with meningomas (12 men, average 50 +/- 12 years; 21 women average 46 +/- 14 years) was examined by immunohistochemical and western blotting. The number of microvessels which were immunostained with von willelrand factor was counted and PVBE was assessed blindly before MRI scan or CT scan.


RESULTS
The expression of VEGF protein was found in 75.8% (25/33). The mean rate of immunostaining was 2.03 and the mean rate of PVBE was 2.39. The rate of staining intensity was correlated with PVBE rate (r = 0.7352, P < 0.01) and vascular counts (r = 0.6974, P < 0.01). VEGF protein isoform of molecular sizes corresponding to VEGF165 was detected in cytosolic extracts of meningomas.


CONCLUSIONS
VEGF is highly related to PVBE and angiogenesis of meningoma. Wide-spread distribution of VEGF in meningomas suggests VEGF165 isoform.
Zhang
Z
Z
Department of Neurosurgery, Union Hospital of Tongji Medical University, Wuhan 430022, China.
Zhao
H
H
Zhu
X
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D001929:Brain Edema / Q000378:metabolism*; D016228:Endothelial Growth Factors / Q000378:metabolism*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008222:Lymphokines / Q000378:metabolism*; D008297:Male; D008579:Meningioma / Q000378:metabolism*; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors