[Preoperative arterial infusion chemotherapy of colorectal carcinoma pathological and clinical effects].
OBJECTIVE
To investigate the pathological and clinical effects of preoperative selective intra-arterial infusion chemotherapy on colorectal carcinoma.


METHODS
30 patients with colorectal carcinoma underwent selective regional arterial angiography by Seldinger's method followed by intra-arterial infusion chemotherapy.


RESULTS
changes of karyopyknosis, karyorrhexis, coagulation and necrosis of cytoplasm in cancer cells around vascular vessels were found in all cases. Interstitial edema, invasion of inflammatory cells, fibroelastosis around cancer cells, proliferous intima, thrombus and inflammation of vessels were also found at the same sites.


CONCLUSIONS
Histological changes are significant after preoperative selective intra-arterial infusion chemotherapy for colorectal carcinoma. This therapy can relieve symptoms.
Gu
J
J
Department of Surgery, People's Hospital, Beijing Medical University, Beijing 100044.
Ma
Z
Z
Ye
Y
Y
Xue
W
W
Qu
J
J
Zhao
Y
Y
Yu
Y
Y
Leng
X
X
Zhu
X
X
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome