[Effect of calmodulin inhibitor on spinal cord injury].
OBJECTIVE
To evaluate the effect of a special calmodulin (CaM) inhibitor-trifluoperizine (TFP) on spinal cord injury (SCI) and the role of CaM in SCI.


METHODS
We observed the effect of TFP on spinal cord blood flow (SCBF), motor evoked potentials (MEP) and motor function in SCI by using hydrogen clearance, inclined plane and electro physiological technique.


RESULTS
There was significant improvement of SCBF, MEP and motor function with TFP, when adrenaline maintained the system arterial pressure in SCI.


CONCLUSIONS
Prevention by TFP of spinal cord function in SCI suggested that CaM plays a role in the pathogenesis of SCI.
Zhang
Y
Y
Department of Orthopedics, 304th Hospital of Chenese People's Liberation Army, Beijing 100037.
Hou
S
S
Liu
R
R
Zhu
Y
Y
Liu
Y
Y
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002147:Calmodulin / Q000037:antagonists & inhibitors* / Q000502:physiology; D019054:Evoked Potentials, Motor / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D013116:Spinal Cord / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000188:drug therapy / Q000503:physiopathology*; D014268:Trifluoperazine / Q000494:pharmacology*
D014150:Antipsychotic Agents; D002147:Calmodulin; D014268:Trifluoperazine