Imaging and quantitation of the hypoxic cell fraction of viable tumor in an animal model of intracerebral high grade glioma using [18F]fluoromisonidazole (FMISO).
We have demonstrated that FMISO uptake is significantly higher in tumor tissue in the C6 intracerebral glioma rat model compared to normal brain, and that there is persisting hypoxia in gliomas independent of tumor size. FMISO uptake was observed homogeneously throughout viable glioma tissue in tumor sizes ranging from 2mm to almost 1cm. Quantitation of uptake of FMISO showed a tumor/brain ratio of 1.9 and a tumor/blood ratio of 2.6 at 2 hours post injection.
Tochon-Danguy
Henri J
HJ
Centre for PET, Austin & Repatriation Medical Centre, 3084, Melbourne, Victoria, Australia. htd@austin.unimelb.edu.au
Sachinidis
John I
JI
Chan
Fiona
F
Chan
J Gordon
JG
Hall
Catherine
C
Cher
Lawrence
L
Stylli
Stan
S
Hill
John
J
Kaye
Andrew
A
Scott
Andrew M
AM
D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D015687:Cell Hypoxia; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics / Q000652:urine; D005910:Glioma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008920:Misonidazole / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; C031843:fluoromisonidazole; D008920:Misonidazole