Chromosomal imbalances identified by comparative genomic hybridization in sporadic parathyroid adenomas.
OBJECTIVE
To identify chromosomal gains and losses in sporadic parathyroid adenomas (PAs).


METHODS
Fourteen sporadic PAs were studied by comparative genomic hybridization (CGH).


RESULTS
The fourteen studied PAs showed chromosomal imbalances. All cases except one exhibited two or more abnormalities. Chromosomal gains were found in all cases, and three cases (21%) also presented chromosomal losses. Genomic amplification was not observed. Chromosome 9 was involved in ten cases. Recurrent genetic gain was found on 9p22-24 and on 9q34, each in 6 of 14 cases (43%). Other recurrent gains included Xq26 in 6 PAs (43%) and 4q21-28 and 8p22-23, each in 4 of 14 cases (29%). Regions of recurrent genetic loss involved whole chromosome 11 and 20q12-13, each in 2 of 14 cases (14%).


CONCLUSIONS
Our findings show chromosomal imbalances in all sporadic PAs studied by CGH, partly confirming previous reports, with the exception that we observed more chromosomal gains than losses. Several regions (9p22-24, 9q34, Xq26, 4q21-28, and 8p22-23) probably deserve further investigation in order to discard the presence of genes involved in parathyroid tumorigenesis.
Garcia
Juan Luis
JL
Centro de Investigacion del Cancer, Universidad de Salamanca-CSIC, Salamanca, Spain.
Tardio
Juan C
JC
Gutierrez
Norma Carmen
NC
Gonzalez
Maria Belen
MB
Polo
Jose Ramon
JR
Hernandez
Jesus Maria
JM
Menarguez
Javier
J
D000236:Adenoma / Q000235:genetics*; D000368:Aged; D002869:Chromosome Aberrations; D002894:Chromosomes, Human, Pair 4; D002898:Chromosomes, Human, Pair 8; D002899:Chromosomes, Human, Pair 9; D016384:Consensus Sequence; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D010282:Parathyroid Neoplasms / Q000235:genetics*; D014960:X Chromosome