Highly cohesive monolayers of lipid derivatives of colchicine: a dynamics study.
Monolayers of lipid derivatives of colchicine spread at the air--water interface reach the thermodynamic equilibrium over an abnormally long period of time. Dynamics of this equilibration and the behavior of the film during compression--decompression cycles are observed by fluorescence microscopy. The thermodynamically disfavored structures observed are unrelated to previously described unusual shapes in the liquid expanded-gas coexistence regions. The relation between the cholesterol-like effect of the colchicinoid moiety, its propensity to dimerize, and the high viscosity of the monolayer are discussed.
Mons
Stephane
S
Faculte de Pharmacie, Laboratoire de Synthèse Bioorganique associé au CNRS, Université Louis Pasteur, 74, route du Rhin BP 24, 67401, Illkirch, France.
Salesse
Christian
C
Mioskowski
Charles
C
Lebeau
Luc
L
D003078:Colchicine / Q000737:chemistry*; D019281:Dimerization; D005456:Fluorescent Dyes; D008055:Lipids / Q000737:chemistry*; D008823:Micelles; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D010714:Phosphatidylethanolamines; D013329:Structure-Activity Relationship; D013499:Surface Properties; D013816:Thermodynamics; D014783:Viscosity
D005456:Fluorescent Dyes; D008055:Lipids; D008823:Micelles; D010714:Phosphatidylethanolamines; D003078:Colchicine