title: Short-term (48 hours) versus long-term (7 days) antibiotic prophylaxis for permanent pacemaker implantation.
abstract: BACKGROUND
  Infection following permanent pacemaker implantation is a dreaded complication. Antibiotic prophylaxis for 1-10 days at the time of implant has been used in the past but there is no consensus regarding its duration. We carried out a prospective, randomized study of two durations of antibiotic prophylaxis to determine which one was more effective.
  
  
  RESULTS
  One hundred and seventy-eight patients undergoing permanent pacemaker implantation for the first time were randomized to receive short duration (group A, n = 8 8) or longer duration (group B, n = 90) antibiotic prophylaxis for 2 days and 7 days, respectively. Patients in both groups received cloxacillin 2 g 2 hours prior to the procedure followed by ampicillin and cloxacillin (50 mg/kg/day in 4 divided doses) and gentamicin (3 mg/kg/day in 2 divided doses) for the respective duration. Patients were followed up for 1-17.3 months (9.3 +/- 1.8 months) in group A and 1-16.5 months (8.9 +/- 2 months) in group B. One patient in group B had an infection at the pacemaker site and two patients in each group had to undergo reimplantation due to pus in the pocket. There was no significant difference in the primary end-point in both groups.
  
  
  CONCLUSIONS
  A short course (48 hours) of antibiotic prophylaxis following permanent pacemaker implantation is as effective as a longer course (7 days).
authors.affiliation: Department of Cardiology, King George's Medical College, Lucknow.
authors.forename: S K
authors.initials: SK
authors.lastname: Dwivedi
authors.forename: R K
authors.initials: RK
authors.lastname: Saran
authors.forename: P
authors.initials: P
authors.lastname: Khera
authors.forename: N
authors.initials: N
authors.lastname: Tripathi
authors.forename: A K
authors.initials: AK
authors.lastname: Kochar
authors.forename: V S
authors.initials: VS
authors.lastname: Narain
authors.forename: V K
authors.initials: VK
authors.lastname: Puri
mesh_terms: D000900:Anti-Bacterial Agents; D019072:Antibiotic Prophylaxis / Q000379:methods*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial / Q000009:adverse effects*; D011446:Prospective Studies; D016459:Prosthesis-Related Infections / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents