Monitoring cytotoxic tumour treatment response by diffusion magnetic resonance imaging and proton spectroscopy.
Exposure of tumours to anti-cancer drugs, gene or radiation therapy consistently leads to an increase in water diffusion in the cases expressing favourable treatment response. The diffusion change coincides cytotoxic cell eradication and precedes volume reduction in drug or gene therapy-treated experimental tumours. Interestingly, the recent studies from human brain tumour patients undergoing chemotherapy show similar behaviour of diffusion, suggesting important application for MRI in patient management. In this review observations from diffusion MRI and MRS in the tumours during cytotoxic treatment are summarized and the cellular mechanisms affecting molecular mobility are discussed in the light of tissue microenvironmental and microdynamic changes.
Kauppinen
Risto A
RA
National Bio-NMR Facility, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland. kauppine@messi.uku.fi
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000628:therapy; D004058:Diffusion; D005110:Extracellular Space; D015316:Genetic Therapy; D005910:Glioma / Q000628:therapy; D006801:Humans; D007424:Intracellular Fluid; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000628:therapy*
D000970:Antineoplastic Agents