title: [Development of new methods in asymmetric reactions and their applications].
abstract: Several novel methods using chiral reagents and biocatalysts for asymmetric reactions are described. Among those reactions, asymmetric reduction via a novel tandem Michael addition/Meerwein-Ponndorf-Verley reduction of acyclic alpha,beta-unsaturated ketones using a chiral mercapto alcohol, asymmetric synthesis of allene-1,3-dicarboxylate via crystallization induced asymmetric transformation, and improved asymmetric nitroolefination of lactones and lactames at alpha-carbon using new chiral reagents were developed. In the reactions using biocatalysts, asymmetric dealkoxycarbonylation of bicyclic beta-keto diesters having sigma-symmetry with lipase or esterase to give optically active beta-keto esters, the asymmetric reduction of bicyclic 1,3-diketones having sigma-symmetry with Baker's yeast to give optically active keto alcohols, and the asymmetric aldol reaction of glycine with threonine aldolase were also developed. The above mentioned products were effectively utilized as chiral building blocks for the asymmetric synthesis of natural products and drugs.
authors.affiliation: Kyoto Pharmaceutical University, 1 Shichono-cho, Misasagi, Yamashina, Kyoto 607-8412, Japan. node@mb.kyoto-phu.ac.jp
authors.forename: Manabu
authors.initials: M
authors.lastname: Node
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D003460:Crystallization; D015195:Drug Design; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D007659:Ketones