[Dynamic change of androgen-receptor in tumor and surrounding liver tissue of nude mice model with transplanted human HCC].
OBJECTIVE
To research into the law of androgen-receptor (AR) dynamic change in developing course of human HCC.


METHODS
Dynamic measurement of AR in tumor and peritumorous tissue was performed in nude mice model with orthotopic transplanted human HCC.


RESULTS
Tumor nodules were present in 90% nude mice 4 weeks after transplantation, tumor necrosis was found in the 10th week, and remarkable necrosis occurred in the 12th week. The quantity of AR in tumor and peritumorous tissue was highest in the early stage of tumor (102.32 +/- 21.42 fmol/mg protein and 72.45 +/- 10.11 fmol/mg protein respectively), and then decreased progressively with time to the 10th week (40.98 +/- 21.11 fmol/mg protein and 53.39 +/- 7.01 fmol/mg protein respectively). The difference in AR between each two weeks was significant.


CONCLUSIONS
Androgen promotes the development of tumor because of existence of AR, and its action may decline after establishment of tumor. Therefore, antiandrogen treatment may be ineffective after establishment of tumor.
Liang
L
L
Department of Hepatobiliary Surgery, First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080.
Zhou
Z
Z
Lu
M
M
Peng
B
B
Lu
H
H
Yin
X
X
He
Q
Q
Huang
J
J
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011944:Receptors, Androgen / Q000378:metabolism*; D013997:Time Factors; D014183:Transplantation, Heterologous
D011944:Receptors, Androgen