Generation of myo-inositol-auxotrophic Leishmania mexicana mutants by targeted replacement of the myo-inositol-1-phosphate synthase gene.
Ilg
Thomas
T
Max-Planck-Institut fur Biologie, Abteilung Membranbiochemie, Corrensstrasse 38, 72076, Tubingen, Germany. thomas.ilg@intervet.com
D000818:Animals; D017353:Gene Deletion; D018390:Gene Targeting; D007294:Inositol / Q000378:metabolism; D007894:Leishmania mexicana / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism / Q000472:pathogenicity; D016773:Leishmaniasis, Cutaneous / Q000469:parasitology* / Q000503:physiopathology; D051379:Mice; D008969:Molecular Sequence Data; D007296:Myo-Inositol-1-Phosphate Synthase / Q000235:genetics* / Q000378:metabolism; D016133:Polymerase Chain Reaction; D014774:Virulence
D007294:Inositol; D007296:Myo-Inositol-1-Phosphate Synthase