Atrichia with papular lesions resulting from mutations in the rhesus macaque (Macaca mulatta) hairless gene.
Atrichia with papular lesions (APL) is a rare form of hair loss with an autosomal recessive mode of inheritance that is characterized by the absence of normal hair follicles, and formation of intradermal cystic structures. Mutations in the hairless (hr) gene in mice and humans have been implicated in the development of this phenotype. Hairless is a putative transcription factor containing a single zinc-finger DNA binding domain, with restricted expression in brain and skin. Here, we describe the complete hr cDNA sequence from the rhesus macaque (Macaca mulatta) and report the identification of a compound heterozygous mutation in a hairless rhesus macaque born from unrelated parents. Cutaneous biopsy samples from the affected macaque revealed abnormalities, including the replacement of normal hair follicles with dermal cysts and comedones, reminiscent of the skin phenotype observed in hairless mice and humans with APL.
Ahmad
Wasim
W
Department of Dermatology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
Ratterree
Marion S
MS
Panteleyev
Andrei A
AA
Aita
Vincent M
VM
Sundberg
John P
JP
Christiano
Angela M
AM
D000505:Alopecia / Q000151:congenital / Q000235:genetics / Q000662:veterinary*; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004252:DNA Mutational Analysis / Q000662:veterinary; D005260:Female; D006579:Heterozygote; D006801:Humans; D008253:Macaca mulatta / Q000235:genetics*; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000235:genetics* / Q000473:pathology; D009154:Mutation; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics*; D051381:Rats; D017444:Skin Diseases, Papulosquamous / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D014157:Transcription Factors; D016335:Zinc Fingers / Q000235:genetics*
C490267:HR protein, human; D011506:Proteins; D014157:Transcription Factors; C088661:hr protein, mouse; C490268:hr protein, rat