[Expression of cell adhesion molecule CD44 variant isoform correlated with the clinical behavior of renal cell carcinoma].
OBJECTIVE
To determinate whether the expression of CD44v in renal cell carcinoma (RCC) is associated with tumor malignant behavior.


METHODS
Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect CD44v in 31 human renal cell carcinoma (RCC) in addition to 18 normal renal tissues from patients with non-malignant disease.


RESULTS
Eighteen RCCs showed positive expression while none of normal renal tissue expressed CD44v (P < 0.001). CD44v was expressed in metastatic or high pathological stage RCC, but the expression of CD44v was not correlated with cellular differentiation.


CONCLUSIONS
Our data indicate that a role for CD44v in human RCC progression and metastases, and CD44v may prove to be a marker for high metastasis potential of RCC.
Long
H
H
Department of Urology, Li Huili Hospital, Ningbo Medical Center, Ningbo 315040.
Chen
C
C
Guo
Z
Z
Yan
C
C
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics*; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D020033:Protein Isoforms / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
D018960:Hyaluronan Receptors; D020033:Protein Isoforms