Expression of proteins: D1 cyclin and Ki-67 in papillary thyroid carcinomas.
The aim of the study was an evaluation of expression of D1 cyclin and Ki-67 proteins in tissue of human papillary thyroid carcinoma (PTC) in a group of papillary microcarcinomas and in a group of PTC with a degree of staging higher than pT1a in TNM classification. We performed immunohistochemical staining and found no statistical differences between groups. These results suggest that changes of expression of D1 cyclin are an early event in tumorigenesis.
Timler
D
D
Department of Endocrinological and General Surgery, Medical University, Lódź, Poland. sokmr@poczta.onet.pl
Tazbir
J
J
Matejkowska
M
M
Gosek
A
A
Czyz
W
W
Brzeziński
J
J
D000328:Adult; D002291:Carcinoma, Papillary / Q000737:chemistry* / Q000473:pathology; D019938:Cyclin D1 / Q000032:analysis*; D005260:Female; D016193:G1 Phase; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D016196:S Phase; D013964:Thyroid Neoplasms / Q000737:chemistry* / Q000473:pathology
D019394:Ki-67 Antigen; D019938:Cyclin D1