title: Unrelated clonal chromosome abnormalities in myelodysplastic syndromes and acute myeloid leukemias.
abstract: Most neoplasms are monoclonal and the tumor cells are believed to be the progeny of a single transformed cell. Clonality has been demonstrated by X-chromosomal enzymes, immunoglobulin and T-cell receptor gene rearrangements, or clonal cytogenetic abnormalities. Nevertheless, cytogenetically unrelated clones with disparate chromosome abnormalities are found infrequently in hematologic malignancies. We report four kinds of coexisting independent clones, +8/+21, der(1;7)/+8, del(9)/-X/i(Xq), and i(7p)/+11, respectively, which to our knowledge mostly have not been reported in same individuals, in two myelodysplastic syndrome and two acute myeloid leukemia cases.
authors.affiliation: Department of Clinical Pathology, Dong-A University College of Medicine, Pusan, South Korea. jyhan@daunet.donga.ac.kr
authors.forename: Jin Yeong
authors.initials: JY
authors.lastname: Han
authors.forename: Kyeong Hee
authors.initials: KH
authors.lastname: Kim
authors.forename: Hyuk Chan
authors.initials: HC
authors.lastname: Kwon
authors.forename: Jae Seok
authors.initials: JS
authors.lastname: Kim
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
mesh_terms: D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*