A new antibiotic CJ-17,665 from Aspergillus ochraceus.
A new antibiotic, CJ-17,665 (I) was isolated from the fermentation broth of Aspergillus ochraceus, CL41582. It inhibits growth of multi-drug resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 microg/ml, respectively. The structure contains a diketopiperazine and an indole N-oxide moiety that is unusual in natural products.
Sugie
Y
Y
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. Yutaka.Sugie@japan.pfizer.com
Hirai
H
H
Inagaki
T
T
Ishiguro
M
M
Kim
Y J
YJ
Kojima
Y
Y
Sakakibara
T
T
Sakemi
S
S
Sugiura
A
A
Suzuki
Y
Y
Brennan
L
L
Duignan
J
J
Huang
L H
LH
Sutcliffe
J
J
Kojima
N
N
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001235:Aspergillus ochraceus / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D013293:Enterococcus faecalis / Q000187:drug effects; D005285:Fermentation; D008401:Gas Chromatography-Mass Spectrometry; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D009904:Optical Rotation; D010879:Piperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects
D000900:Anti-Bacterial Agents; D007659:Ketones; D010879:Piperazines