title: Functional cell-based uHTS in chemical genomic drug discovery.
abstract: The availability of genomic information significantly increases the number of potential targets available for drug discovery, although the function of many targets and their relationship to disease is unknown. In a chemical genomic research approach, ultra-high throughput screening (uHTS) of genomic targets takes place early in the drug discovery process, before target validation. Target-selective modulators then provide drug leads and pharmacological research tools to validate target function. Effective implementation of a chemical genomic strategy requires assays that can perform uHTS for large numbers of genomic targets. Cell-based functional assays are capable of the uHTS throughput required for chemical genomic research, and their functional nature provides distinct advantages over ligand-binding assays in the identification of target-selective modulators.
authors.affiliation: ACADIA Pharmaceuticals, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA. gcroston@acadia-pharm.com
authors.forename: Glenn E
authors.initials: GE
authors.lastname: Croston
mesh_terms: D001667:Binding, Competitive / Q000502:physiology; D002478:Cells, Cultured; D002621:Chemistry / Q000379:methods; D019295:Computational Biology / Q000379:methods; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004347:Drug Interactions / Q000502:physiology; D023281:Genomics / Q000379:methods*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology