Rapid efficacy of highly active antiretroviral therapy in a case of HIV myelitis.
An HIV-seropositive patient with severe immunodepression was diagnosed as having HIV myelitis. Plasma and cerebrospinal fluid (CSF) HIV-RNA PCR were, respectively, 4.11 and 5.19log(10). After 1 month of treatment with highly active antiretroviral therapy (HAART), there was clinical recovery and both plasma and CSF HIV viral load had decreased considerably. This dramatic improvement was associated with a high concentration of antiviral drugs in the CSF, suggestive of the direct efficacy of HAART on HIV myelitis.
Michou
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Service de Medicine Interne, Ho^pital Saint-Louis, Lavande 6, 1, avenue Claude Vellfaux, F-75475 Cedex 10, Paris, France
Sauve
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C
Sereni
C
C
Lamotte
C
C
Maillard
A
A
Sereni
D
D