title: Benzylidene rhodanines as novel inhibitors of UDP-N-acetylmuramate/L-alanine ligase.
abstract: Benzylidene rhodanines are novel inhibitors of UDP N-acetylmuramate/L-alanine ligase. They showed selective whole-cell activity against the Gram-positive MRSA but not against the Gram-negative Escherichia coli. Their cytotoxic effect on mammalian CHO cells was also evaluated.
authors.affiliation: Medicinal and Combinatorial Chemistry Laboratory, Institute of Molecular and Cell Biology, 30Medical Drive, 117609, Singapore, Singapore. mcbsimmm@imcb.nus.edu.sg
authors.forename: Mui Mui
authors.initials: MM
authors.lastname: Sim
authors.forename: Siew Bee
authors.initials: SB
authors.lastname: Ng
authors.forename: Antony David
authors.initials: AD
authors.lastname: Buss
authors.forename: Sharon Carmelita
authors.initials: SC
authors.lastname: Crasta
authors.forename: Kah Lin
authors.initials: KL
authors.lastname: Goh
authors.forename: Sue Kim
authors.initials: SK
authors.lastname: Lee
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001597:Benzylidene Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D016466:CHO Cells / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010453:Peptide Synthases / Q000037:antagonists & inhibitors*; D012236:Rhodanine / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001597:Benzylidene Compounds; D004791:Enzyme Inhibitors; D012236:Rhodanine; D010453:Peptide Synthases; C023229:UDP-N-acetylmuramoyl-alanine synthetase