Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050.
A new preussomerin isomer, 3'-O-demethylpreussomerin I, five known preussomerins E - I, and two known deoxypreussomerins, deoxypreussomerin A and bipendensin (palmarumycin C11), were isolated from a lichenicolous fungus Microsphaeropsis sp. BCC 3050. These structures were elucidated by spectroscopic methods, especially 1D- and 2D-NMR. The preussomerins were evaluated for their antimycobacterial and antiplasmodial activities as well as cytotoxicity against KB, BC-1 and vero cell lines.
Seephonkai
Prapairat
P
Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
Isaka
Masahiko
M
Kittakoop
Prasat
P
Palittapongarnpim
Prasit
P
Kamchonwongpaisan
Sumalee
S
Tanticharoen
Morakot
M
Thebtaranonth
Yodhathai
Y
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D004852:Epoxy Compounds; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010961:Plasmodium / Q000187:drug effects; D018675:Toxicity Tests; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000962:Antimalarials; D000995:Antitubercular Agents; D004852:Epoxy Compounds; D006576:Heterocyclic Compounds, 4 or More Rings; C410322:preussomerin I