[Perioperative changes of plasma ET-1 in patients undergoing coronary artery bypass grafting and the effect of nitroglycerin].
OBJECTIVE
To observe the dynamic changes of the plasma ET-1 and the effect of low dose nitroglycerin in patients with coronary artery bypass surgery.


METHODS
40 patients with coronary artery bypass surgery were divided into group A and B. Group B received intravenous nitroglycerin 1 microg x kg(-1) x min(-1) perioperatively. We used RIA to assay the plasma ET-1 level. All the hemodynamic parameters were recorded by the Swan-Ganz catheter.


RESULTS
The preoperative plasma ET-1 level in patients with coronary artery disease was significantly higher than the normal level. Five minutes after cardiopulmonary bypass in these patients the plasma ET-1 level was increased significantly until 6 to 8 hours after operation. The increased plasma ET-1 level in group B was less than in group A. There was a positive correlation between the plasma ET-1 level and the mean pulmonary pressure in group A 2 and 8 hours after operation.


CONCLUSIONS
In patients undergoing coronary artery bypass surgery, the increased plasma ET-1 level may be partly due to the influence of cardiopulmonary bypass. Low dose of nitroglycerin is beneficial to these patients.
Chen
X
X
Department of Cardiothoracic Surgery, Nanjing First Hospital, Nanjng Medical University, Nanjing 210006, China.
Jiang
Y
Y
Xu
M
M
Bao
H
H
Mu
X
X
Xiao
L
L
Guo
Z
Z
D001026:Coronary Artery Bypass; D019332:Endothelin-1 / Q000097:blood*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*; D019990:Perioperative Care; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology
D019332:Endothelin-1; D014665:Vasodilator Agents; D005996:Nitroglycerin