title: A founder factor VIII mutation, valine 2016 to alanine, in a population with an extraordinarily high prevalence of mild hemophilia A.
authors.forename: Y G
authors.initials: YG
authors.lastname: Xie
authors.forename: H
authors.initials: H
authors.lastname: Zheng
authors.forename: J
authors.initials: J
authors.lastname: Leggo
authors.forename: M F
authors.initials: MF
authors.lastname: Scully
authors.forename: D
authors.initials: D
authors.lastname: Lillicrap
mesh_terms: D019943:Amino Acid Substitution; D003062:Codon / Q000235:genetics; D005091:Exons / Q000235:genetics; D005169:Factor VIII / Q000737:chemistry / Q000235:genetics*; D018703:Founder Effect; D006467:Hemophilia A / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D009523:Newfoundland and Labrador / Q000453:epidemiology; D017354:Point Mutation; D015995:Prevalence; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D014960:X Chromosome / Q000235:genetics
chemical_list: D003062:Codon; D005169:Factor VIII