Unrelated clonal chromosome abnormalities in myelodysplastic syndromes and acute myeloid leukemias.
Most neoplasms are monoclonal and the tumor cells are believed to be the progeny of a single transformed cell. Clonality has been demonstrated by X-chromosomal enzymes, immunoglobulin and T-cell receptor gene rearrangements, or clonal cytogenetic abnormalities. Nevertheless, cytogenetically unrelated clones with disparate chromosome abnormalities are found infrequently in hematologic malignancies. We report four kinds of coexisting independent clones, +8/+21, der(1;7)/+8, del(9)/-X/i(Xq), and i(7p)/+11, respectively, which to our knowledge mostly have not been reported in same individuals, in two myelodysplastic syndrome and two acute myeloid leukemia cases.
Han
Jin Yeong
JY
Department of Clinical Pathology, Dong-A University College of Medicine, Pusan, South Korea. jyhan@daunet.donga.ac.kr
Kim
Kyeong Hee
KH
Kwon
Hyuk Chan
HC
Kim
Jae Seok
JS
Kim
Hyo Jin
HJ
Lee
Young Ho
YH
D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*