title: Surface, corrosion and biocompatibility aspects of Nitinol as an implant material.
abstract: The present review surveys studies on physical-chemical properties and biological response of living tissues to NiTi (Nitinol) carried out recently, aiming at an understanding of the place of this material among the implant alloys in use. Advantages of shape memory and superelasticity are analyzed in respect to functionality of implants in the body. Various approaches to surface treatment, sterilization procedures, and resulting surface conditions are analyzed. A review of corrosion studies conducted both on wrought and as-cast alloys using potentiodynamic and potentiostatic techniques in various corrosive media and in actual body fluids is also given. The parameters of localized and galvanic corrosion are presented. The corrosion behavior is analyzed with respect to alloy composition, phase state, surface treatment, and strain and compared to that of conventional implant alloys. Biocompatibility of porous Nitinol, Ni release and its effect on living cells are analyzed based on understanding of the surface conditions and corrosion behavior. Additionally, the paper offers a brief overview of the comparative toxicity of metals, components of commonly used medical alloys, indicating that the biocompatibility profile of Nitinol is conducive to present in vivo applications.
authors.forename: Svetlana A
authors.initials: SA
authors.lastname: Shabalovskaya
mesh_terms: D016475:3T3 Cells; D000388:Air; D000497:Alloys / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D003343:Corrosion; D004305:Dose-Response Relationship, Drug; D004563:Electrochemistry; D004577:Electron Probe Microanalysis; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008422:Materials Testing; D051379:Mice; D009532:Nickel / Q000737:chemistry / Q000633:toxicity; D010100:Oxygen / Q000378:metabolism; D019736:Prostheses and Implants; D013314:Stress, Mechanical; D014867:Water / Q000378:metabolism
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D014867:Water; C013616:nitinol; D009532:Nickel; D010100:Oxygen