B7 costimulation plays an important role in protection from herpes simplex virus type 2-mediated pathology.
We have used mice lacking both B7-1 and B7-2 costimulation molecules (B7KO) to investigate the effects of B7 costimulation on herpes simplex virus type 2 (HSV-2) pathogenesis. B7KO mice infected intravaginally with virulent HSV-2 showed more severe genital and neurologic disease and higher mortality rates than their wild-type counterparts. These results suggest that B7 costimulation molecules play an important role in the development of primary immune responses protective against HSV-2.
Thebeau
Lydia G
LG
Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 Grand Boulevard, St. Louis, Missouri 63104, USA.
Morrison
Lynda A
LA
D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D018122:B7-1 Antigen / Q000235:genetics / Q000378:metabolism*; D051940:B7-2 Antigen; D006558:Herpes Genitalis / Q000276:immunology* / Q000401:mortality / Q000503:physiopathology; D018258:Herpesvirus 2, Human / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology
D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497964:CD86 protein, human; C497965:Cd86 protein, mouse; D008562:Membrane Glycoproteins