Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain.
The gene encoding human neuroblastoma apoptosis-related RNA binding protein (NAPOR) has rat and mouse homologues, Etr-r3 and mNapor, cloned recently by ourselves and others. Etr-r3/mNapor is transcribed in embryonic brain but its detailed expression patterns are unknown. It has been hypothesised that its expression coincides with the occurrence of programmed cell death, but existing expression data are insufficient to evaluate this possibility. We used northern blots and in situ hybridisation to show that Etr-r3/mNapor is expressed by most postmitotic differentiating cells throughout the forebrain during embryogenesis and the first weeks of postnatal life. Expression is particularly high in the developing cerebral cortex, in nuclei of the ventral telencephalon, in dorsal thalamus and in hypothalamus. In contrast, Etr-r3/mNapor is expressed by very few cells in proliferative regions, where cell death rates are highest.
Levers
Teresa E
TE
Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK.
Tait
Steven
S
Birling
Marie-Christine
MC
Brophy
Peter J
PJ
Price
David J
DJ
D000818:Animals; D015152:Blotting, Northern; D000067878:CELF Proteins; D016923:Cell Death; D002454:Cell Differentiation; D002455:Cell Division; D002540:Cerebral Cortex / Q000196:embryology; D018076:DNA, Complementary / Q000378:metabolism; D007031:Hypothalamus / Q000196:embryology; D051379:Mice; D009419:Nerve Tissue Proteins; D016548:Prosencephalon / Q000196:embryology* / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics*; D051381:Rats; D013687:Telencephalon / Q000196:embryology; D013788:Thalamus / Q000196:embryology; D013997:Time Factors
D000067878:CELF Proteins; C117363:CELF2 protein, human; D018076:DNA, Complementary; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins