title: Phenytoin toxicity with mandibular tremor secondary to intravenous administration.
abstract: The parenteral form of phenytoin is the most commonly used antiepileptic agent during the perioperative period in neurosurgery clinics. We report observations in a 52-year-old male patient with hypoalbuminemia and phenytoin intoxicity following 1 day preoperative administration and a 7-day postoperative intravenous administration of the drug with no modification of the oral dose. This report emphasizes the need for careful surveillance of phenytoin-induced toxicity during parenteral therapy, especially in debilitated patients.
authors.affiliation: Institute of Neurological Sciences, University of Marmara, Maltepe, Istanbul, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Türkdogan
authors.forename: F
authors.initials: F
authors.lastname: Onat
authors.forename: U
authors.initials: U
authors.lastname: Türe
authors.forename: N
authors.initials: N
authors.lastname: Pamir
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects* / Q000097:blood; D017029:Epilepsy, Complex Partial / Q000188:drug therapy; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage* / Q000009:adverse effects* / Q000097:blood; D014202:Tremor / Q000139:chemically induced*
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin