Use of Etests with carbapenems for Gram-negative rods producing beta-lactamases.
The in vitro activity of imipenem and meropenem on strains of Gram-negative rods producing extended-spectrum beta-lactamase (ESBL) and inducible beta-lactamase (IBL) was studied using the Etest. In all, 185 strains from the surgical intensive care units of four different hospitals were looked at over 2 years. Of these, 94 were ESBL producers and 91 were IBL positive. The in vitro sensitivities of imipenem and meropenem were 89.7 and 95.1%, respectively, against all strains. The imipenem and meropenem sensitivities of Klebsiella spp. were 98.4 and 100%, respectively, but imipenem resistance (21.6%) in Pseudomonas aeruginosa strains was higher than that of meropenem (10.8%).
Kocazeybek
Bekir S
BS
Cerrahpaşa Medical Faculty, Microbiology and Clinical Microbiology Department, University of Istanbul, Cerrahpaşa, Istanbul, Turkey. bekirkcz@superonline.com
Arabaci
Umit
U
D024901:Drug Resistance, Multiple, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology; D016946:Gram-Negative Aerobic Rods and Cocci / Q000187:drug effects* / Q000201:enzymology*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D011548:Pseudomonadaceae / Q000187:drug effects / Q000201:enzymology; D013045:Species Specificity; D013845:Thienamycins / Q000494:pharmacology*; D001618:beta-Lactamases / Q000378:metabolism*
D013845:Thienamycins; D015378:Imipenem; D001618:beta-Lactamases; D000077731:Meropenem