Towards the structure of the mammalian signal recognition particle.
The signal recognition particle (SRP) is a ubiquitous ribonucleoprotein particle involved in the co-translational targeting of proteins to membranes. Crystal structures are now available for three protein-RNA subcomplexes from the SRP, which give insights into fundamental aspects of protein-RNA recognition, the assembly of stable ribonucleoprotein particles and the mechanism of action of the SRP.
Wild
Klemens
K
Biochemie-Zentrum (BZH), University of Heidelberg, Im Neuenheimer Feld 328, D-69120, Heidelberg, Germany.
Weichenrieder
Oliver
O
Strub
Katharina
K
Sinning
Irmgard
I
Cusack
Stephen
S
D020087:Alu Elements; D000818:Animals; D001483:Base Sequence; D004926:Escherichia coli; D008322:Mammals; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D012313:RNA / Q000737:chemistry; D012329:RNA, Bacterial / Q000737:chemistry; D016601:RNA-Binding Proteins / Q000737:chemistry; D018271:Signal Recognition Particle / Q000737:chemistry* / Q000502:physiology
D012329:RNA, Bacterial; D016601:RNA-Binding Proteins; C117074:SRP19 protein, human; D018271:Signal Recognition Particle; D012313:RNA