Bifunctional derivative of p,p'-dichlorochalcone. Part III. Synthesis and study for cytotoxic activity of a new compound, 2-[2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-thiazolidin-4-one from p,p'-dichlorochalcone.
The synthesis of 2-(2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-thiazolidin-4-one (3) from p,p'-dichlorochalcone (1) via 1,3,3-tris(4-chlorophenyl)-propan-1-one (2) using thioglycollic acid in the presence of ammonium carbonate is described. Structural assignment, stereochemistry and biological assay are discussed.
Singh
Shishu Pal
SP
Department of Chemistry, Aligarh Muslim University, Aligarh 202 002, India.
Ansari
Wajid Husain
WH
Lemière
Guy
G
Jonckers
Tim
T
Dommisse
Roger
R
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives / Q000737:chemistry*; D047188:Chalcones; D002722:Chlorobenzenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D003432:Cross-Linking Reagents; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D053778:Thiazolidines; D014407:Tumor Cells, Cultured
C456419:2-(2,2-bis(4-chlorophenyl)ethyl)-2-(4-chlorophenyl)thiazolidin-4-one; C456420:4,4'-dichlorochalcone; D000970:Antineoplastic Agents; D047188:Chalcones; D002722:Chlorobenzenes; D003432:Cross-Linking Reagents; D013844:Thiazoles; D053778:Thiazolidines; D002599:Chalcone