title: Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease.
abstract: In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off- and on-drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L-dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L-dopa. GPi stimulation and L-dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity, the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase. This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L-dopa.
authors.affiliation: Department of Gait Analysis, University of Lille, Lille, France. Ldefebvre@chru-lille.fr
authors.forename: Luc J P
authors.initials: LJ
authors.lastname: Defebvre
authors.forename: Pierre
authors.initials: P
authors.lastname: Krystkowiak
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Blatt
authors.forename: Alain
authors.initials: A
authors.lastname: Duhamel
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Bourriez
authors.forename: Myriame
authors.initials: M
authors.lastname: Périna
authors.forename: Serge
authors.initials: S
authors.lastname: Blond
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Guieu
authors.forename: Alain
authors.initials: A
authors.lastname: Destée
mesh_terms: D000978:Antiparkinson Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004185:Disability Evaluation; D004599:Electric Stimulation Therapy / Q000379:methods*; D005260:Female; D005684:Gait / Q000187:drug effects*; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D007980:Levodopa / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000175:diagnosis; D010300:Parkinson Disease / Q000188:drug therapy / Q000628:therapy*; D011187:Posture
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa