Pyrrolo[1,2-f]phenanthridines and related non-rigid analogues as antiviral agents.
The pyrrolo[1,2-f]phenanthridines 8-22 and the corresponding non-rigid analogues 23-41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10, 11, and 13 showed a weak anti-HIV activity, whereas several pyrrolo-phenanthridines (8, 10, 16-18) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition.
Almerico
Anna Maria
AM
Dipartimento Farmacochimico, Tossicologico e Biologico, Universita' degli Studi, Via Archirafi 32-90123, Palermo, Italy. almerico@unipa.it
Mingoia
Francesco
F
Diana
Patrizia
P
Barraja
Paola
P
Montalbano
Alessandra
A
Lauria
Antonino
A
Loddo
Roberta
R
Sanna
Laura
L
Delpiano
Donatella
D
Setzu
Maria Giovanna
MG
Musiu
Chiara
C
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008958:Models, Molecular; D010617:Phenanthridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D010617:Phenanthridines; D011758:Pyrroles