Iridoids with anti-inflammatory activity from Vitex peduncularis.
A new iridoid, pedunculariside, together with the known iridoid agnuside were isolated from the butanol extract of Vitex peduncularis stem bark. Both pedunculariside and agnuside showed preferential inhibition of COX-2, with IC50 values of 0.15 +/- 0.21 mg/ml and 0.026 +/- 0.015 mg/ml respectively, while having only small inhibitory effects on COX-1. Both compounds did not exhibit cytotoxicity against vero cells.
Suksamrarn
A
A
Department of Chemistry, Ramkhamhaeng University, Bangkok, Thailand. apichart@ram1.ru.ac.th
Kumpun
S
S
Kirtikara
K
K
Yingyongnarongkul
B
B
Suksamrarn
S
S
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D039823:Iridoids; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008565:Membrane Proteins; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014709:Vero Cells / Q000166:cytology / Q000187:drug effects; D020950:Vitex
D000893:Anti-Inflammatory Agents; D005960:Glucosides; D039823:Iridoids; D007527:Isoenzymes; D008565:Membrane Proteins; D010936:Plant Extracts; D011714:Pyrans; C452959:pedunculariside; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; C496512:Ptgs1 protein, mouse; C452960:agnuside