Regulatory role of SGT1 in early R gene-mediated plant defenses.
Animal SGT1 is a component of Skp1-Cullin-F-box protein (SCF) ubiquitin ligases that target regulatory proteins for degradation. Mutations in one (SGT1b) of two highly homologous Arabidopsis SGT1 genes disable early plant defenses conferred by multiple resistance (R) genes. Loss of SGT1b function in resistance is not compensated for by SGT1a. R genes differ in their requirements for SGT1b and a second resistance signaling gene, RAR1, that was previously implicated as an SGT1 interactor. Moreover, SGT1b and RAR1 contribute additively to RPP5-mediated pathogen recognition. These data imply both operationally distinct and cooperative functions of SGT1 and RAR1 in plant disease resistance.
Austin
Mark J
MJ
Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK.
Muskett
Paul
P
Kahn
Katherine
K
Feys
Bart J
BJ
Jones
Jonathan D G
JD
Parker
Jane E
JE
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D016923:Cell Death; D017343:Genes, Plant; D007113:Immunity, Innate; D047908:Intracellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D009154:Mutation; D009868:Oomycetes / Q000472:pathogenicity / Q000502:physiology; D010935:Plant Diseases; D018515:Plant Leaves / Q000382:microbiology; D010940:Plant Proteins / Q000235:genetics* / Q000502:physiology; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D013172:Spores, Fungal / Q000502:physiology
D029681:Arabidopsis Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D047908:Intracellular Signaling Peptides and Proteins; C499581:PBS2 protein, Arabidopsis; D010940:Plant Proteins; C107295:RPP5 protein, Arabidopsis; C452191:SGT1a protein, Arabidopsis; C452192:SGT1b protein, Arabidopsis