The hemangioblast: a common progenitor of hematopoietic and endothelial cells.
In the developing embryo, the initial hematopoietic and vascular structure can be identified as the blood islands of the yolk sac. Blood islands are formed from mesodermal aggregates that have migrated from the primitive streak. The outer cells differentiate into endothelial cells and the inner to primitive blood. The close developmental association between hematopoietic and endothelial cell lineages has led to a hypothesis that they share a common progenitor, the hemangioblast. This review will examine emerging studies supporting the existence of such cells in order to further understand how the hematopoietic and vascular systems are established during mouse development.
Choi
Kyunghee
K
School of Medicine, Department of Pathology and Immunology, Washington University, 660 South Euclid Avenue, St. Louis, MO 63110, USA. kchoi@immunology.wustl.edu
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D004730:Endothelium, Vascular / Q000166:cytology / Q000196:embryology; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D018919:Neovascularization, Physiologic / Q000187:drug effects; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects