title: Measurement of physical strength of pharmaceutical extruded pellets.
abstract: This paper describes a novel and simple method for measuring the physical strength of pharmaceutical pellets prepared by extrusion granulation. Pharmaceutical powders composed of lactose, cornstarch, and microcrystalline cellulose were kneaded with purified water and dry binder (hydroxypropylcellulose), then extruded through a dome-type extrusion granulator. The physical strength of the dried extruded pellets was measured with a novel system: pellets and grinding alumina media were both fed into a ball mill pot and then "grinding degree" was measured as defined by the ground fine powder fraction after being rotated in the pot. The grinding conditions such as grinding time and number of alumina balls were optimized. The measured physical strength and pellet strength measured with a typical strength tester was compared. Quantitative relationships between the strength and the physical properties of the pellets such as friability and disintegration time were also investigated. It was found that the newly developed system could easily and accurately evaluate the physical strength of extruded pellets and could also predict the various physical properties.
authors.affiliation: Department of Chemical Engineering, Osaka Prefecture University, Sakai, Japan. watano@chemeng.osakafu-u.ac.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Watano
authors.forename: Eri
authors.initials: E
authors.lastname: Shimoda
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Osako
mesh_terms: D019245:Compressive Strength; D005079:Excipients / Q000737:chemistry; D010316:Particle Size; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000295:instrumentation* / Q000379:methods*
chemical_list: D005079:Excipients