title: Effect of low-dose irradiation on induction of an apoptotic adaptive response in the murine system.
abstract: The aim of the study was to investigate the effect of low doses of irradiation on the induction of an apoptotic adaptive response in the murine system using C3H/HeJ mice bearing 8 mm syngeneic tumors, HCa-I and OCa-I. In OCa-I, the 0.05 Gy priming dose significantly reduced the 25 Gy-induced apoptosis by 30%, whereas this reduction was not seen in HCa-I. The analysis of apoptosis-regulating molecules showed that the application of a priming dose increased the radiation-induced p53 level in both tumors. No other regulators changed in OCa-I. However, in HCa-I, the application of a priming dose increased radiation-induced Bcl-XL and Bcl-XS, but not Bcl-2 or Bax. An apoptotic adaptive response induced by low-dose radiation was shown in one murine tumor, OCa-I and Bcl-XL and Bcl-XS appeared to be implicated.
authors.affiliation: Department of Radiation Oncology, Yonsei University Medical College, Seoul, Korea. jsseong@yumc.yonsei.ac.kr
authors.forename: J
authors.initials: J
authors.lastname: Seong
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: H R
authors.initials: HR
authors.lastname: Pyo
authors.forename: E J
authors.initials: EJ
authors.lastname: Chung
authors.forename: C O
authors.initials: CO
authors.lastname: Suh
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D015153:Blotting, Western; D053938:DNA Fragmentation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D014407:Tumor Cells, Cultured