Quantification of adenovirus DNA in plasma for management of infection in stem cell graft recipients.
We used a real-time polymerase chain reaction method for quantification of adenovirus to monitor the dynamics of viral DNA load in plasma in pediatric stem-cell graft recipients. Two cases are described to demonstrate that detection and quantification of the adenovirus DNA load at regular intervals may be important to document the stage of adenovirus infection, to make decisions on clinical intervention, and to accurately monitor the response to antiviral therapy.
Lankester
A C
AC
Department of Pediatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. a.lankester@lumc.nl
van Tol
M J D
MJ
Claas
E C J
EC
Vossen
J M
JM
Kroes
A C M
AC
D000256:Adenoviridae / Q000235:genetics / Q000502:physiology*; D000258:Adenovirus Infections, Human / Q000188:drug therapy; D002648:Child; D004279:DNA, Viral / Q000097:blood*; D016903:Drug Monitoring; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D019737:Transplants; D019562:Viral Load
D004279:DNA, Viral