Human neuronal calcium sensor-1 shows the highest expression level in cerebral cortex.
Neuronal calcium sensors (NCS) are important constituents in the intracellular signaling pathways. A novel human gene, NCS-1, was identified in the present study. Among the 16 human tissues examined, NCS-1 is expressed most abundantly in the brain. Among the brain regions, the expression level of NCS-1 in cerebral cortex is the highest, which is about six times higher than the average level of the whole brain and a hundred times higher than the spinal cord. In the 12 different anatomical regions of human brain, the expression level of NCS-1 is very high in the temporal lobe, occipital pole, frontal lobe, thalamus, amygdala and hippocampus; moderate in cerebellum, putamen, caudate nucleus; low in the medulla, substantia nigra and the lowest in corpus callosum. Our results suggest that NCS-1 in human brain might be involved in a variety of brain functions such as sensory processing, motor control, emotional control, learning and memory.
Chen
Chiyuan
C
State Key Laboratory of Genetics Engineering, Institute of Genetics, School of Life Sciences, Fudan University, No. 220, Handan Road, Shanghai, PR China.
Yu
Long
L
Zhang
Pingzhao
P
Jiang
Jianming
J
Zhang
Yazhou
Y
Chen
Xiaosong
X
Wu
Qi
Q
Wu
Qianhong
Q
Zhao
Shouyuan
S
D015152:Blotting, Northern; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002540:Cerebral Cortex / Q000378:metabolism*; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000032:analysis / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D008969:Molecular Sequence Data; D051580:Neuronal Calcium-Sensor Proteins; D009474:Neurons / Q000378:metabolism*; D009479:Neuropeptides / Q000235:genetics*; D010802:Phylogeny; D012333:RNA, Messenger / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D002135:Calcium-Binding Proteins; D018076:DNA, Complementary; D005819:Genetic Markers; D051580:Neuronal Calcium-Sensor Proteins; D009479:Neuropeptides; D012333:RNA, Messenger; C101464:frequenin calcium sensor proteins; D002118:Calcium