Human metabotropic glutamate receptor 2 gene (GRM2): chromosomal sublocalization (3p21.1-p21.2) and genomic organization.
Imbalances in glutamatergic function have been implicated in the pathogenesis of neuropsychiatric disorders. Consequently, glutamate receptors genes are promising candidates in search of susceptibility genes for these disorders. In the present study, we report the chromosomal sublocalization and genomic organization of the human metabotropic glutamate receptor 2 gene (GRM2). Using monochromosomal hybrid cell lines of NIGMS Mapping Panel 2 (Coriell Cell Repository), the GRM2 gene was localized to human chromosome 3, confirming previously reported localization. In addition, using the radiation hybrid panel RH3 (Research Genetics), we sublocalized the GRM2 gene to chromosomal region 3p21.1-p21.2. The genomic organization of the GRM2 gene was established using a premade library of adaptor-ligated, human-specific genomic DNA fragments. The gene consists of 5 exons, with sizes ranging from 74 to 1,076 bp.
Martí
Sylvia Bort
SB
Institute of Human Genetics, University of Bonn, Bonn, Germany. borts@tcd.ie
Cichon
Sven
S
Propping
Peter
P
Nöthen
Markus
M
D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*; D017422:Sequence Analysis, DNA
D018094:Receptors, Metabotropic Glutamate; C108822:metabotropic glutamate receptor 2