title: Wall stress misrepresents afterload in children and young adults with abnormal left ventricular geometry.
abstract: Wall stress, although commonly used as an index of afterload, fails to take into account forces generated within the wall of the left ventricle (LV) that oppose systolic fiber shortening. Wall stress may, therefore, misrepresent fiber stress, the force resisting fiber shortening, particularly in the presence of an abnormal LV thickness-to-dimension ratio (h/D). M-mode LV echocardiograms were obtained from 207 patients with a wide range of values for LV mass and/or h/D. Diagnoses were valvar aortic stenosis, coarctation repair, anthracycline treated, and severe aortic and/or mitral regurgitation. End-systolic wall stress (WS(es)) and fiber stress (FS(es)) were expressed as age-corrected Z scores relative to a normal population. The difference between WS(es) and FS(es) was extreme when h/D was elevated or reduced [WS(es) Z score - FS(es) Z score = 0.14 x (h/D)(-1.47) - 2.13; r = 0.78, P < 0.001], with WS(es) underestimating FS(es) when h/D was increased and overestimating FS(es) when h/D was decreased. Analyses of myocardial mechanics based on wall stress have limited validity in patients with abnormal ventricular geometry.
authors.affiliation: Department of Paediatric Cardiology, Green Lane Hospital, Auckland 1003, New Zealand. tomg@adhb.govt.nz
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Gentles
authors.forename: Steven D
authors.initials: SD
authors.lastname: Colan
mesh_terms: D000293:Adolescent; D000328:Adult; D018943:Anthracyclines / Q000627:therapeutic use; D001017:Aortic Coarctation / Q000503:physiopathology; D001022:Aortic Valve Insufficiency / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D006331:Heart Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006352:Heart Ventricles; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008944:Mitral Valve Insufficiency / Q000503:physiopathology; D008955:Models, Cardiovascular; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D012016:Reference Values; D013314:Stress, Mechanical
chemical_list: D018943:Anthracyclines