Mutator bacteria as a risk factor in treatment of infectious diseases.
We show in a gnotobiotic mouse model that, in addition to direct selection of antibiotic-resistant bacteria, some antibiotic treatments also select for mutator alleles. Because of these mutator alleles' high mutation rates, the initial treatment failure increases the probability of failures in subsequent treatments with other drugs.
Giraud
Antoine
A
UEPSD-FBI, Bat 440-CRJ-Institut National de la Recherche Agronomique, 78352 Jouy-en-Josas, France.
Matic
Ivan
I
Radman
Miroslav
M
Fons
Michel
M
Taddei
François
F
D000483:Alleles; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000235:genetics* / Q000382:microbiology*; D015169:Colony Count, Microbial; D004064:Digestive System / Q000382:microbiology; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D005856:Germ-Free Life; D051379:Mice; D008809:Mice, Inbred C3H; D009154:Mutation / Q000235:genetics*; D012307:Risk Factors
D000900:Anti-Bacterial Agents