Effects of paraquat on essential antioxidant elements in osteogenic disorder Shionogi rat.
This study reports the effect of paraquat (PQ) on concentrations of four elements (Cu, Fe, Mg, Zn) in lung, kidney, spleen, liver, and heart of male osteogenic disorder Shionogi (ODS) rats, a strain not able to synthesize vitamin C. PQ significantly increased the Cu concentrations in lung, liver, and plasma, accompanied by a fall in renal levels. Fe levels were elevated in liver and spleen but lowered in plasma. PQ produced an increase in kidney Mg and a rise in liver Mg and Zn levels. Cardiac elemental levels were not affected by PQ treatment. PQ, a known oxidant, produced changes in tissue elements involved in antioxidant mechanisms.
Minakata
Kayoko
K
Department of Legal Medicine, Hamamatsu University School of Medicine, Japan. kminakat@hama-med.ac.jp
Suzuki
Osamu
O
Saito
Shin-ichi
S
Kawai
Kaori
K
Horio
Fumihiko
F
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D006540:Herbicides / Q000493:pharmacokinetics / Q000633:toxicity*; D008297:Male; D008670:Metals / Q000378:metabolism*; D010269:Paraquat / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D014018:Tissue Distribution / Q000187:drug effects
D000975:Antioxidants; D006540:Herbicides; D008670:Metals; D010269:Paraquat