[Effectiveness of treatment of recurrences of non-Hodgkin's lymphoma after combined chemoradiotherapy depending on prognostic indicators].
The results were evaluated of the management of non-Hodgkin's lymphomas in 46 out of 150 patients relapsing after first complete remission, following early-stage chemoradiotherapy. Polychemotherapy of recurrent tumors was given to 85% (39/46), repeat combined treatment--13% (6/46) and radiotherapy--2% (1/46). Remission was reported in 91% (42/46): complete--69% (32) and partial--22% (10). Remission frequency and duration directly depended on degree of risk (IPI), stage of recurrence development and advancement, tumor size and general symptoms of intoxication. There was no relationship between frequency and duration, on the one hand, and sex and age, tumor pattern or number of involvement areas, on the other. Instead, the efficacy was influenced by the general condition of the patient, damage to the lymph nodes rather than adjacent areas as well as number of such areas. LDH blood level impacted the end results.
Kruglova
G V
GV
N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.
Finogenova
I A
IA
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy; D008224:Lymphoma, Follicular / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011879:Radiotherapy Dosage; D012008:Recurrence; D012074:Remission Induction; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors
D007770:L-Lactate Dehydrogenase