[Dynamic monitoring of serum soluble HLA class I antigens in renal transplant recipients].
OBJECTIVE
To investigate the relations between serum soluble HLA class I antigens (sHLA-I) and the period of acute rejection and infection in renal transplant recipients.


METHODS
We measured the serum levels of sHLA-I in 36 renal transplant recipients with ELISA dynamically.


RESULTS
The serum sHAL-I levels were higher in uremia patients than in normal controls [(2.94 +/- 0.34) microg/L vs. (0.76 +/- 0.33) microg/L, P < 0.05]. After renal transplantation, the serum sHLA-I levels decreased significantly in stable patients [(0.63 +/- 0.33) microg/L], but increased significantly 3 days before acute rejection and 5 or 7 days after infection.


CONCLUSIONS
The serum sHLA-I levels can be used as a parameter for monitoring acute rejection and infection in renal transplantation.
Xu
J
J
Department of Kidney Transplantation, Nanfang Hospital, First Military Medical University, Guangzhou 510515.
Cao
Q
Q
Wu
D
D
Ma
J
J
Yu
L
L
D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000209:etiology / Q000276:immunology*; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006680:HLA Antigens / Q000097:blood*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015166:Monitoring, Immunologic; D011183:Postoperative Complications; D014511:Uremia / Q000276:immunology / Q000601:surgery
D006680:HLA Antigens