Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism.
We present the results of a study using vibrational circular dichroism (VCD) for (+)-1, which furnished an unambiguous determination of its absolute configuration as S. The most abundant conformation of (+)-1 in CDCl(3) solution was also established.
Dyatkin
Alexey B
AB
The R.W. Johnson Pharmaceutical Research Institute, Drug Discovery, Spring House, Pennsylvania 19477-0766, USA.
Freedman
Teresa B
TB
Cao
Xiaolin
X
Dukor
Rina K
RK
Maryanoff
Bruce E
BE
Maryanoff
Cynthia A
CA
Matthews
Jay M
JM
Shah
Rekha D
RD
Nafie
Laurence A
LA
D065092:Antidiuretic Hormone Receptor Antagonists; D001569:Benzodiazepines / Q000737:chemistry*; D002942:Circular Dichroism; D008968:Molecular Conformation; D012997:Solvents; D013055:Spectrophotometry, Infrared
D065092:Antidiuretic Hormone Receptor Antagonists; D012997:Solvents; D001569:Benzodiazepines