Hypercalcemia induced by parathyroid hormone-related peptide after treatment of carcinoma.
Squamous cell carcinoma of the head and neck is a rare cause of humoral hypercalcemia of malignancy. This paraneoplastic syndrome is usually one of the presenting symptoms of the disease. We report a case of squamous cell carcinoma of the oral cavity that presumably elaborated parathyroid hormone-related peptide (PTH-rP) and caused hypercalcemia only after radiotherapy and chemotherapy.
Gover
Alina
A
Department of Medicine, Huron Hospital, Cleveland Clinic Health System, OH 44112, USA.
Kumar
P Dileep
PD
Brown
Leon A
LA
Ravakhah
Keyvan
K
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D009384:Paraneoplastic Endocrine Syndromes / Q000209:etiology; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism*; D011878:Radiotherapy / Q000009:adverse effects
C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins