Differential expression of viral Bcl-2 encoded by Kaposi's sarcoma-associated herpesvirus and human Bcl-2 in primary effusion lymphoma cells and Kaposi's sarcoma lesions.
Expression of human herpesvirus 8 viral Bcl-2 protein was demonstrated in spindle cells of late-stage Kaposi's sarcoma lesions but not in primary effusion lymphoma cell lines. In contrast, strong expression of human Bcl-2 was found in stimulated primary effusion lymphoma cells, whereas in Kaposi's sarcoma lesions preferential mononuclear cells, and to a lesser extent spindle cells, stained positive.
Widmer
Isabelle
I
Institute for Medical Microbiology, University of Basel, Petersplatz 10, CH-4003 Basel, Switzerland.
Wernli
Marion
M
Bachmann
Felix
F
Gudat
Fred
F
Cathomas
Gieri
G
Erb
Peter
P
D019288:Herpesvirus 8, Human / Q000235:genetics* / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D012509:Sarcoma / Q000378:metabolism / Q000821:virology; D012514:Sarcoma, Kaposi / Q000378:metabolism* / Q000821:virology; D014407:Tumor Cells, Cultured
D019253:Proto-Oncogene Proteins c-bcl-2