High serum luteinizing hormone and testosterone concentrations do not predict pregnancy outcome in women with recurrent miscarriage.
OBJECTIVE
To investigate the relationship between Day 8 serum luteinizing hormone (LH) and testosterone (T) concentrations, and body mass index (BMI) with pregnancy outcome in women with recurrent miscarriage.


METHODS
Prospective observational study.


METHODS
National recurrent miscarriage clinic.


METHODS
Three hundred forty-four women (median age 32 years; range 18-44) with a history of recurrent first trimester miscarriage (median 4; 3-14; <12 weeks gestation) who conceived spontaneously and who received no pharmacological treatment during pregnancy were studied. All women were antiphospholipid antibody negative and had a normal peripheral karyotype as did their partners.


METHODS
Outcome of untreated pregnancies.


METHODS
Day 8 serum LH and T concentrations and BMI were correlated with pregnancy outcome.


RESULTS
One hundred and ninety-two (55.8%) women had a live birth and 152 (44.2%) women miscarried. Polycystic ovarian morphology was diagnosed in 174 women (50.6%). There was no significant relationship between follicular phase LH concentrations and pregnancy outcome. Pregnancy outcome was similar in women with normal and high serum T concentrations. BMI value was not significantly different between women who had a live birth and those who miscarried.


CONCLUSIONS
The analysis of this large cohort of women with recurrent miscarriage demonstrates that prepregnancy Day 8 serum LH and T concentrations, and BMI do not have a statistically significant relationship with pregnancy outcome.
Nardo
Luciano G
LG
Department of Reproductive Science and Medicine, Imperial College School of Medicine, St Mary's Hospital, Praed Street, London W2 1PG, United Kingdom.
Rai
Raj
R
Backos
May
M
El-Gaddal
Safaa
S
Regan
Lesley
L
D000026:Abortion, Habitual / Q000097:blood*; D000293:Adolescent; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D013739:Testosterone / Q000097:blood*
D017153:Antibodies, Anticardiolipin; D016682:Lupus Coagulation Inhibitor; D013739:Testosterone; D007986:Luteinizing Hormone