title: Placing the newborn on the maternal abdomen increases the volume of umbilical cord blood collected.
abstract: Haematopoietic stem cell transplantation is an important therapy for certain haematological and malignant disorders. Umbilical cord blood contains a high proportion of potentially transplantable haematopoietic progenitor cells. However, the use of cord blood stem cell transplantation is limited by the low number of stem cells obtainable from a single cord blood donor. The aim of our study was to investigate the possibility that procedures during delivery might influence the number of umbilical cord blood haematopoietic progenitor cells available for transplantation. We assessed the effects of upper and lower positions of the newborn infant on the yield of cord blood stem cells in 51 vaginal deliveries. Neonates in the upper position group were placed by the midwife on the maternal abdomen immediately after birth, while those in the lower position group were placed on the delivery table, below the maternal introitus. The total volume of cord blood and the total number of CD34+ cells collected from babies in the upper position group were significantly higher than those from babies in the lower position group. There were no significant differences in cord blood haemoglobin levels and white blood cell counts between the two groups, nor were there any adverse effects in the newborn infants. The simple manoeuvre of placing the newborn on the maternal abdomen after delivery may thus increase the yield of transplantable haematopoietic progenitor cells in cord blood.
authors.affiliation: Department of Microbiological and Gynaecological Sciences, University of Catania, Italy. pafumi@mbox.unict.it
authors.forename: C
authors.initials: C
authors.lastname: Pafumi
authors.forename: G
authors.initials: G
authors.lastname: Zizza
authors.forename: A
authors.initials: A
authors.lastname: Russo
authors.forename: M
authors.initials: M
authors.lastname: Farina
authors.forename: G
authors.initials: G
authors.lastname: Pernicone
authors.forename: S
authors.initials: S
authors.lastname: Bandiera
authors.forename: P
authors.initials: P
authors.lastname: Giardina
authors.forename: L
authors.initials: L
authors.lastname: Mangiafico
authors.forename: R
authors.initials: R
authors.lastname: Mancari
authors.forename: I
authors.initials: I
authors.lastname: Maggi
authors.forename: A E
authors.initials: AE
authors.lastname: Calogero
authors.forename: A
authors.initials: A
authors.lastname: Cianci
mesh_terms: D000005:Abdomen; D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D001800:Blood Specimen Collection / Q000379:methods*; D002452:Cell Count; D036861:Delivery, Obstetric; D005260:Female; D005312:Fetal Blood / Q000166:cytology* / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009035:Mothers; D011187:Posture; D011247:Pregnancy; D014470:Umbilical Cord
chemical_list: D018952:Antigens, CD34