Effect of anticonvulsant drugs on interleukins-1, -2 and -6 and monocyte chemoattractant protein-1.
In order to evaluate whether treatment with valproic acid or carbamazepine can modify interleukins and monocyte chemoattractant protein-1, we studied 40 epileptic children and adolescents. We evaluated the patients before and after 1 year of therapy. At the end of follow-up, the patients showed a significant increase of the production of interleukin-1alpha, interleukin-1beta, interleukin-6, and monocyte chemoattractant protein-1; interleukin-2 production was significantly higher only in patients receiving carbamazepine. In conclusion, antiepileptic drugs can influence the immune system by modifying interleukin and chemokine concentrations; these changes seem to be independent of the serum concentrations of these drugs.
Verrotti
A
A
Department of Medicine, University of Chieti, Ospedale Policlinico, Italy. averrott@obelix.unich.it
Basciani
F
F
Trotta
D
D
Greco
R
R
Morgese
G
G
Chiarelli
F
F
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use; D018932:Chemokine CCL2 / Q000378:metabolism*; D002648:Child; D004827:Epilepsy / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D007376:Interleukin-2 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D014635:Valproic Acid / Q000627:therapeutic use
D000927:Anticonvulsants; D018932:Chemokine CCL2; D007375:Interleukin-1; D007376:Interleukin-2; D015850:Interleukin-6; D002220:Carbamazepine; D014635:Valproic Acid