Macrocyclic diterpenes from Euphorbia nivulia.
The latex of Euphorbia nivulia afforded two ingol diterpenes 3,12-diacetyl-8-benzoylingol (4) and 3,12-diacetyl-7-benzoyl-8-nicotinylingol (5) along with three known ingol diterpenes 1, 2,and 3, and two known triterpenes cycloart-25-en-3beta-ol and cyclonivulinol. Their structures have been assigned on the basis of their structural data as well as their acetylated products. The diterpenes 1-5 were tested for the LPS induced PGE(2) inhibition activity.
Ravikanth
V
V
Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
Niranjan Reddy
V L
VL
Prabhakar Rao
T
T
Diwan
P V
PV
Ramakrishna
S
S
Venkateswarlu
Y
Y
D015232:Dinoprostone / Q000037:antagonists & inhibitors; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification
D004224:Diterpenes; D014315:Triterpenes; D015232:Dinoprostone