Life in the fast lane: high-throughput chemistry for lead generation and optimisation.
The pharmaceutical industry has come under increasing pressure due to regulatory restrictions on the marketing and pricing of drugs, competition, and the escalating costs of developing new drugs. These forces can be addressed by the identification of novel targets, reductions in the development time of new drugs, and increased productivity. Emphasis has been placed on identifying and validating new targets and on lead generation: the response from industry has been very evident in genomics and high throughput screening, where new technologies have been applied, usually coupled with a high degree of automation. The combination of numerous new potential biological targets and the ability to screen large numbers of compounds against many of these targets has generated the need for large diverse compound collections. To address this requirement, high-throughput chemistry has become an integral part of the drug discovery process.
Hunter
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Discovery Research, High-Throughput Chemistry, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, United Kingdom. david_hunter@gsk.com
D001331:Automation / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000639:trends*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004526:Efficiency; D023281:Genomics; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical / Q000639:trends*
D004364:Pharmaceutical Preparations