title: Alteration of biochemical parameters related with exposure to lead in heavy alcohol drinkers.
abstract: Blood lead levels (PbB), delta-ALA dehydratase activity (ALAD) and erythrocytic protoporphyrin (EPP) values were studied in heavy wine and spirit drinkers. Results were compared in both groups and with a control group (teetotalers). Results in all cases are expressed as arithmetic means +/- SD. PbB values found in the three groups were statistically different inter se: wine group, 195 +/- 82 microg l(-1); spirits group, 159 +/- 69 microg l(-1); teetotalers, 72 +/- 43 microg l(-1). ALAD was significantly lower in the drinker groups (wine 26.9 plus minus 11.4 U l(-1)and spirits 28.3 plus minus 11.6 U l(-1))vs the control group (48.3 plus minus 13.5 U l(-1)). Differences in EPP levels in the three groups were only significant between the teetotaler and the wine drinker groups. Our findings indicate that, in heavy drinkers (more than 2 liters of wine per day), not only are lead levels increased in the blood but there are also biochemical alterations that affect the heme biosynthetic pathway, which should be taken into account in treatment for alcoholics.
authors.affiliation: Toxicology and Legal Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
authors.forename: C M
authors.initials: CM
authors.lastname: Lopez
authors.forename: N E
authors.initials: NE
authors.lastname: Vallejo
authors.forename: A E
authors.initials: AE
authors.lastname: Piñeiro
authors.forename: R
authors.initials: R
authors.lastname: Uicich
authors.forename: C F
authors.initials: CF
authors.lastname: Damin
authors.forename: M I
authors.initials: MI
authors.lastname: Sarchi
authors.forename: E C
authors.initials: EC
authors.lastname: Villaamil Lepori
authors.forename: O E
authors.initials: OE
authors.lastname: Roses
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D000434:Alcoholic Beverages / Q000009:adverse effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007854:Lead / Q000097:blood*; D008297:Male; D000623:Porphobilinogen Synthase / Q000378:metabolism*; D011524:Protoporphyrins / Q000378:metabolism*
chemical_list: D011524:Protoporphyrins; D007854:Lead; D000623:Porphobilinogen Synthase