Nitric oxide metabolites in gnotobiotic piglets orally infected with Salmonella enterica serovar typhimurium.
Reactive NO metabolites play a distinct role in the control of Salmonella enterica serovar Typhimurium (ST; a facultative intracellular pathogen) in susceptible host. A significant increase of nitrite and/or nitrate plasma levels, 3-nitro-tyrosine expression and pathological changes in mesenteric lymph nodes have been observed in gnotobiotic piglets orally infected for 1 d with a virulent strain of ST but not in piglets infected with a rough mutant of ST.
Trebichavský
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Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 549 22 Nový Hrádek, Czechia. treb@biomed.cas.cz
Zídek
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Franková
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Zahradnícková
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Splíchal
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D000818:Animals; D005856:Germ-Free Life; D007124:Immunoenzyme Techniques; D007422:Intestines / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure; D008168:Lung / Q000648:ultrastructure; D008198:Lymph Nodes / Q000378:metabolism / Q000648:ultrastructure; D008643:Mesentery; D008854:Microscopy, Electron; D009569:Nitric Oxide / Q000378:metabolism*; D010587:Phagocytosis; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D012486:Salmonella typhimurium / Q000472:pathogenicity*; D013552:Swine; D013556:Swine, Miniature; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000378:metabolism*; D014774:Virulence
D009569:Nitric Oxide; C002744:3-nitrotyrosine; D014443:Tyrosine