title: Naive and memory B cells in T-cell-dependent and T-independent responses.
abstract: This review focuses on the properties and roles of distinct subsets among the primary and the memory B lymphocytes regarding their contribution to helper-T-cell-dependent and -independent antibody responses. The naive/memory B cell functions are explained in the context of current concepts on the basic mechanisms of humoral immunity. Differences between murine and human B cells are also discussed.
authors.affiliation: Division of Hematology, Geneva University Hospital, 1211 Geneva 14, Switzerland. rudolf.zubler@hcuge.ch
authors.forename: R H
authors.initials: RH
authors.lastname: Zubler
mesh_terms: D000818:Animals; D000917:Antibody Formation; D017951:Antigen Presentation / Q000276:immunology; D000955:Antigens, T-Independent / Q000276:immunology; D053264:B-Cell Activating Factor; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D020013:Calcium Signaling; D002455:Cell Division; D003713:Dendritic Cells / Q000276:immunology; D018858:Germinal Center / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D007114:Immunization; D017578:Immunoglobulin Class Switching; D007156:Immunologic Memory / Q000276:immunology*; D008213:Lymphocyte Activation; D008565:Membrane Proteins / Q000502:physiology; D051379:Mice; D010950:Plasma Cells / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D012756:Sheep; D027041:Somatic Hypermutation, Immunoglobulin; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D000955:Antigens, T-Independent; D053264:B-Cell Activating Factor; D008565:Membrane Proteins; D011947:Receptors, Antigen, B-Cell; C505719:TNFSF13B protein, human; C505720:Tnfsf13b protein, mouse; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D014409:Tumor Necrosis Factor-alpha