cGMP, but not cAMP, in rat hippocampus is involved in early stages of object memory consolidation.
The present study investigates the role of cGMP and cAMP on the memory performance in the object recognition task in rats. The analogue 8-Br-GMP or 8-Br-cAMP was administered bilaterally into the hippocampus (0, 1, 3 and 10 microg in 0.5 microl saline/site) immediately after the exposure to two identical objects. After 24 h, saline-treated animals spent equal times exploring a new and the familiar object demonstrating that they did not recognize the familiar one. However, a dose-dependent improvement in object recognition was found after injection of 8-Br-cGMP. In contrast, 8-Br-cAMP did not improve the memory performance at the doses tested. These results indicate that hippocampal cGMP but not cAMP is involved in early stages of consolidation of object memory.
Prickaerts
Jos
J
Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience 'EURON', Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. jos.prickaerts@npunimaas.nl
de Vente
Jan
J
Honig
Wiel
W
Steinbusch
Harry W M
HW
Blokland
Arjan
A
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology*; D000818:Animals; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D015124:8-Bromo Cyclic Adenosine Monophosphate; C016276:8-bromocyclic GMP; D006152:Cyclic GMP