title: Dental extractions in patients maintained on oral anticoagulant therapy: comparison of INR value with occurrence of postoperative bleeding.
abstract: The purpose of this study was to evaluate the incidence of postoperative bleeding in patients treated with oral anticoagulant medication who underwent dental extractions without interruption of the treatment and to analyze the incidence of postoperative bleeding according to the International Normalized Ratio (INR) value. The 249 patients who underwent 543 dental extractions were divided into five groups: Group 1 with INRs of 1.5-1.99, Group 2 with INRs of 2-2.49, Group 3 with INRs of 2.5-2.99, Group 4 with INRs of 3-3.49 and Group 5 with INRs>3.5. The INR was measured on the day of the procedure. Local haemostasis was carried out with gelatin sponge and multiple silk sutures. Of the 249 patients, 30 presented with postoperative bleeding (12%): Group 1, three patients presented with bleeding (5%), Group 2, 10 patients (12.8%), Group 3, nine patients (15.2%), Group 4, five patients (16.6%) and Group 5, three patients (13%). The incidence of postoperative bleeding was not significantly different among the five groups. The value of the INR at the therapeutic dose did not significantly influence the incidence of postoperative bleeding. Thus, dental extractions can be performed without modification of oral anticoagulant treatment. Local haemostasis with gelatin sponge and sutures appears to be sufficient to prevent postoperative bleeding.
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Chaim Sheba Medical Center, Tel Hashomer, Israel. aleshkov@netvision.net.il
authors.forename: D
authors.initials: D
authors.lastname: Blinder
authors.forename: Y
authors.initials: Y
authors.lastname: Manor
authors.forename: U
authors.initials: U
authors.lastname: Martinowitz
authors.forename: S
authors.initials: S
authors.lastname: Taicher
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D003374:Coumarins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003475:Curettage; D003731:Dental Caries / Q000628:therapy; D005260:Female; D005781:Gelatin Sponge, Absorbable / Q000627:therapeutic use; D006488:Hemostasis, Surgical; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D019476:Insect Proteins; D019934:International Normalized Ratio / Q000145:classification; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000628:therapy; D019106:Postoperative Hemorrhage / Q000209:etiology* / Q000517:prevention & control; D047011:Silk; D013223:Statistics as Topic; D013536:Suture Techniques; D013537:Sutures; D014081:Tooth Extraction; D014148:Tranexamic Acid / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D003374:Coumarins; D006490:Hemostatics; D019476:Insect Proteins; D047011:Silk; D014148:Tranexamic Acid; C030123:coumarin