Plasticity-driven gene expression in the rat retina.
Animals exposed to an enriched environment display features of neural plasticity such as an increased brain volume, enhanced number of dendritic spines, as well as enlarged synapses. Here we report the first description of molecular plasticity in the mammalian retina, as revealed by gene expression. A marked upregulation of both NGFI-A and Arc, two candidate-plasticity genes, was observed in adult rats that had been exposed to an enriched environment for 3 weeks. This increase was paralleled by an increase in the expression of the late genes GAP-43 and Synapsin I, which also indicated changes in retinal connectivity. Our results suggest that both NGFI-A and Arc may regulate mechanisms of plasticity that had been invoked by heightened complexity of the visual environment.
Pinaud
Raphael
R
Department of Anatomy and Neurobiology, Laboratory of Molecular Neurobiology, Dalhousie University, Nova Scotia B3H 4H7, Halifax, Canada.
Tremere
Liisa A
LA
Penner
Marsha R
MR
Hess
Felipe F
FF
Barnes
Steven
S
Robertson
Harold A
HA
Currie
R William
RW
D000818:Animals; D002452:Cell Count; D003598:Cytoskeletal Proteins / Q000096:biosynthesis / Q000235:genetics; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics; D051766:Early Growth Response Protein 1; D004777:Environment; D005106:Exploratory Behavior; D005136:Eye Proteins / Q000096:biosynthesis / Q000235:genetics*; D019922:GAP-43 Protein / Q000096:biosynthesis / Q000235:genetics; D005786:Gene Expression Regulation; D017781:Genes, Immediate-Early; D006234:Handling, Psychological; D006799:Housing, Animal; D017874:Immediate-Early Proteins / Q000096:biosynthesis; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics; D009473:Neuronal Plasticity / Q000235:genetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000166:cytology / Q000378:metabolism*; D016704:Synapsins / Q000096:biosynthesis / Q000235:genetics; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics
D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; C486110:Egr1 protein, rat; D005136:Eye Proteins; D019922:GAP-43 Protein; D017874:Immediate-Early Proteins; D009419:Nerve Tissue Proteins; D016704:Synapsins; D014157:Transcription Factors; C092069:activity regulated cytoskeletal-associated protein