[Influence of gravity change on EGF-induced signal transduction].
With the development of aerospace technology, biological effects induced by alteration of gravitation are drawing more and more attention. Among them the influence of alteration of gravitation on cytokine-induced signal transduction has been well studied recently. Epidermal growth factor (EGF)-induced signal transduction can activate increase of cell proliferation in most cell types, so it is always a hotspot in these years. Among the early effects evoked by EGF are receptor clustering, cell rounding, and early gene expression. After the study about the induction of EGF on human A431 cell line, it was observed that EGF-induced c-fos and c-jun expression decreased in microgravity. This was caused by alteration of the EGF receptor and protein kinase C-mediated signal transduction pathways. Meanwhile the key component of cytoskeleton, the actin microfilament system, was found to be linked to the EGF-induced signal transduction cascades either. So it seems reasonable to suggest that the cytoskeleton constitutes the gravity-sensitive cell component.
Zhang
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Y
Department of Aerospace Medicine, The Fourth Military Medical University, Xi'an, China.
Wu
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XY
Chen
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SM
D008841:Actin Cytoskeleton / Q000502:physiology; D000199:Actins / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002460:Cell Line; D004815:Epidermal Growth Factor / Q000502:physiology*; D018466:Gravity Sensing / Q000502:physiology*; D018470:Gravity, Altered; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D013026:Space Flight; D014893:Weightlessness
D000199:Actins; D004815:Epidermal Growth Factor