title: [Effects of theraphthal-Lio on hemostasis in experimental animals].
abstract: Teraphtal-Lio (Tph) exerted a toxic dose-dependent effect on the hemostatic system. Treatment of experimental animals with maximum tolerated and highly toxic doses was followed by acute DVS syndrome formation involving a hemophilic condition, soaring activated partial prothrombin time, absence of fibrinogen, sharp rise in fibrinogen degradation product and D-dimer matched by fall in thrombocyte count. No toxic influence on the hemostatic system was registered when Tph doses recommended for humans in the course of phase II clinical trials were administered to animals.
authors.affiliation: N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Madzhuga
authors.forename: N P
authors.initials: NP
authors.lastname: Ermakova
authors.forename: E L
authors.initials: EL
authors.lastname: Chlenova
authors.forename: O N
authors.initials: ON
authors.lastname: Koniaeva
authors.forename: O V
authors.initials: OV
authors.lastname: Somonova
authors.forename: A L
authors.initials: AL
authors.lastname: Elizarova
authors.forename: L M
authors.initials: LM
authors.lastname: Mikhaĭlova
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000633:toxicity*; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects / Q000633:toxicity*; D007275:Injections, Intravenous; D008297:Male; D051381:Rats
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; C403768:theraphthal