Chemistry of zinc(II) fluorophore sensors.
The biological role of the zinc(II) ion has been recognized in DNA and RNA synthesis, apoptosis, gene expression, or protein structure and function. Therefore, development of useful zinc(II) sensors has recently been attracting much interest. Chemistry for selective and efficient detection of trace Zn2+ is a central issue. Recently, various types of zinc-fluorophores are emerging, comprising bio-inspired aromatic sulfonamide derivatives, zinc-finger peptides attached to fluorescent dyes, or fluorophore-pendant macrocyclic polyamines. The chemical principles, properties and limitations of these Zn2+-fluorophores are discussed.
Kimura
E
E
Department of Medicinal Chemistry, Faculty of Medicine, Hiroshima University, Japan. ekimura@hiroshima-u.ac.jp
Aoki
S
S
D000595:Amino Acid Sequence; D000818:Animals; D015374:Biosensing Techniques; D002256:Carbonic Anhydrases / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry; D015032:Zinc / Q000032:analysis*
D002614:Chelating Agents; D005456:Fluorescent Dyes; D010455:Peptides; D002256:Carbonic Anhydrases; D015032:Zinc