Resistance of succinic acid dimethyl ester insulinotropic action to exendin (9-39) amide.
Exendin (9-39) amide (Ex [9-39]) was recently proposed for use in the treatment of alimentary or reactive hypoglycaemia. It was indeed found to antagonise the insulinotropic action of GLP-1 in rats infused with the dimethyl ester of succinic acid (SAD). We have now investigated whether, under comparable experimental conditions, Ex (9-39) also opposes the insulin-releasing action of SAD itself. Since this was not the case, Ex (9-39) could be safely used to abolish the incretin effect of GLP-1 without interfering with the control of insulin secretion by circulating nutrients.
Cancelas
J
J
Fundación Jiménez Diaz, Madrid, Spain.
García-Martínez
J A
JA
Villanueva-Peñacarrillo
M L
ML
Valverde
I
I
Malaisse
W J
WJ
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013386:Succinates / Q000037:antagonists & inhibitors*
D001786:Blood Glucose; D007328:Insulin; D010446:Peptide Fragments; D013386:Succinates; C083773:exendin (9-39); C056451:dimethyl succinate