Synthesis and vasorelaxant activity of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans.
A series of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans related to cromakalim (1) has been prepared and their vasorelaxant activities on isolated rat thoracic aorta precontracted with phenylephrine have been evaluated. The relaxant mechanism of 3a was found not through ATP-sensitive K(+) channels as cromakalim, but through opening voltage-sensitive K(+) channels.
Chiou
Wen Fei
WF
National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC.
Li
Shyh Yuan
SY
Ho
Li Kang
LK
Hsien
Ming Ling
ML
Don
Ming Jaw
MJ
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D015221:Potassium Channels / Q000187:drug effects; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D015221:Potassium Channels; D011714:Pyrans; D014665:Vasodilator Agents