title: Effect of anticonvulsant drugs on interleukins-1, -2 and -6 and monocyte chemoattractant protein-1.
abstract: In order to evaluate whether treatment with valproic acid or carbamazepine can modify interleukins and monocyte chemoattractant protein-1, we studied 40 epileptic children and adolescents. We evaluated the patients before and after 1 year of therapy. At the end of follow-up, the patients showed a significant increase of the production of interleukin-1alpha, interleukin-1beta, interleukin-6, and monocyte chemoattractant protein-1; interleukin-2 production was significantly higher only in patients receiving carbamazepine. In conclusion, antiepileptic drugs can influence the immune system by modifying interleukin and chemokine concentrations; these changes seem to be independent of the serum concentrations of these drugs.
authors.affiliation: Department of Medicine, University of Chieti, Ospedale Policlinico, Italy. averrott@obelix.unich.it
authors.forename: A
authors.initials: A
authors.lastname: Verrotti
authors.forename: F
authors.initials: F
authors.lastname: Basciani
authors.forename: D
authors.initials: D
authors.lastname: Trotta
authors.forename: R
authors.initials: R
authors.lastname: Greco
authors.forename: G
authors.initials: G
authors.lastname: Morgese
authors.forename: F
authors.initials: F
authors.lastname: Chiarelli
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use; D018932:Chemokine CCL2 / Q000378:metabolism*; D002648:Child; D004827:Epilepsy / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D007376:Interleukin-2 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D018932:Chemokine CCL2; D007375:Interleukin-1; D007376:Interleukin-2; D015850:Interleukin-6; D002220:Carbamazepine; D014635:Valproic Acid