title: Resolution of recurrent perianal condylomata acuminata by topical cidofovir in patients with HIV infection.
abstract: Anogenital condylomata acuminata are the most frequent clinical manifestation of genital human papillomavirus (HPV) infection. Association between human immunodeficiency virus (HIV) and HPV infections is frequent (range: 26-60% in males). Topical cidofovir (a nucleotide analogue antiviral drug active against a broad range of DNA viruses) is a potential treatment for anogenital warts in immunocompromised patients. We treated three HIV-infected patients with HPV perianal condylomas with topical 1% cidofovir in flexible collodion once a day for 2 weeks. The treatment resulted in complete clearance of the HPV lesions. The patients experienced mild transient erythema without any other side-effects. None of the patients relapsed during the 10-14-month follow-up period.
authors.affiliation: Infectious Diseases Unit, Azienda Ospedaliera Careggi, Florence, Italy. fohle@tin.it
authors.forename: C
authors.initials: C
authors.lastname: Martinelli
authors.forename: A
authors.initials: A
authors.lastname: Farese
authors.forename: A D
authors.initials: AD
authors.lastname: Mistro
authors.forename: S
authors.initials: S
authors.lastname: Giorgini
authors.forename: I
authors.initials: I
authors.lastname: Ruffino
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy*; D000287:Administration, Topical; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D000077404:Cidofovir; D003218:Condylomata Acuminata / Q000175:diagnosis / Q000188:drug therapy*; D003596:Cytosine / Q000008:administration & dosage* / Q000031:analogs & derivatives; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage*; D012008:Recurrence; D012720:Severity of Illness Index; D017193:Skin Diseases, Viral / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir