Endothelial damage during myocardial preservation and storage.
Preservation and storage techniques represent two major issues in routine cardiac surgery and heart transplantation. Historically, these methods were conceived to prevent ischemic injury to myocardium after cardiac arrest during heart operations. Evidence shows that endothelium plays a critical role in the maintenance of normal heart function after cardiac operation, mainly by controlling the coronary circulation. Methods for preservation and storage, developed initially to protect cardiomyocyte function, may be deleterious for vascular endothelium and compromise myocardial protection. In this review article the present knowledge about endothelial injury secondary to preservation and storage techniques is discussed.
Parolari
Alessandro
A
Department of Cardiac Surgery, University of Milan, Centro Cardiologico, Fondazione Monzino IRCCS, Italy. alessandro.parolari@cardiologicomonzino.it
Rubini
Patrizia
P
Cannata
Aldo
A
Bonati
Luigi
L
Alamanni
Francesco
F
Tremoli
Elena
E
Biglioli
Paolo
P
D002314:Cardioplegic Solutions / Q000009:adverse effects; D003326:Coronary Circulation / Q000502:physiology; D015925:Cryopreservation; D004730:Endothelium, Vascular / Q000503:physiopathology*; D016027:Heart Transplantation / Q000502:physiology*; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology*; D009926:Organ Preservation; D012307:Risk Factors
D002314:Cardioplegic Solutions