[Effects of Bay K8644 and nifedipine on L-type Ca2+ channels in hypothalamic neurons of rats].
To investigate the effects of Bay K8644 and nifedipine on L-type of Ca2+ channels in hypothalamic neurons, the cell-attached patch-clamp technique was used to record Ca2+ current from isolated neurons. The results showed that the averaged open time and NPo were markedly increased by Bay K8644, but had no effect on channel conductance. Nifedipine, on the contrary, had an inhibitory effect on the L-type Ca2+ channels.
Fu
Q J
QJ
Department of Thermal Environment Medicine, First Military Medical University, Guangzhou 510515.
Zou
F
F
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology*; D000818:Animals; D002120:Calcium Channel Agonists / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D004594:Electrophysiology; D005260:Female; D007031:Hypothalamus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002120:Calcium Channel Agonists; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D009543:Nifedipine