Normal outcome of pregnancy in chronic myeloid leukemia treated with interferon-alpha in 1st trimester: report of 3 cases and review of the literature.
Three patients with chronic myeloid leukemia (CML) in chronic phase received interferon-alpha during pregnancy, starting from the 1st trimester. No maternal complications were reported. The 3 patients delivered normal looking babies apart from one baby who was found to have transient mild thrombocytopenia. Subsequently these children were followed for 30, 12, and 4 months and all had normal growth and development.
Mubarak
A A S
AA
Hamad Medical Corporation, Department of Medicine, Hematology/Oncology Division, Doha, Qatar.
Kakil
I R
IR
Awidi
A
A
Al-Homsi
U
U
Fawzi
Z
Z
Kelta
M
M
Al-Hassan
A
A
D000328:Adult; D005260:Female; D005865:Gestational Age; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First
D016898:Interferon-alpha