A solid-phase route to N-cyanoamides.
[reaction: see text] A new method for the solid-phase synthesis of cyanamides is described. The attachment of a secondary amine to solid support is accomplished using Merrifield resin. After functionalization, cleavage is readily achieved with cyanogen bromide to afford the desired cyanamide.
Morgan
Trevor
T
Celltech R&D Ltd., Granta Park, Great Abington, Cambridge CB1 6GS, UK.
Ray
Nicholas C
NC
Parry
David M
DM
D002384:Catalysis; D003488:Cyanogen Bromide; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D009570:Nitriles / Q000138:chemical synthesis*; D011759:Pyrrolidines / Q000138:chemical synthesis*
D015853:Cysteine Proteinase Inhibitors; D007202:Indicators and Reagents; D009570:Nitriles; D011759:Pyrrolidines; D003488:Cyanogen Bromide