title: Renal effects of essential fatty acid deficiency in hydropenic and volume-expanded rats.
abstract: The aim of this paper was to study the effects of essential fatty acid (EFA) on fractional sodium excretion (FE(Na(+))) and renal hemodynamics in rats during hydropenia (H) and acute volume expansion (VE), successively. Mean arterial pressure (MAP) and renal blood flow (RBF) were measured using a blood pressure transducer and a flow probe, respectively, both connected to a flowmeter. Glomerular filtration rate (GFR) was estimated by inulin clearance. The rats receiving coconut oil as only source of dietary lipids (the EFA-deficient group) presented lower levels of linoleic acid in cortex and medulla and lower body weight than the rats receiving soy oil in place of coconut oil (the control non-EFA-deficient group). During H, the EFA-deficient rats exhibited a lower level of renal vascular resistance resulting in a higher level of RBF and a higher urinary flow (V') and FE(Na(+)), although GFR was lower than in the control group. During VE, the rats of the control group responded with increased MAP, RBF, V' and FE(Na(+)), which were not found in the EFA-deficient group, suggesting an impaired hemodynamic adjustment in EFA deficiency. In conclusion, both experimental conditions revealed that EFA deficiency affects the renal hemodynamics.
authors.affiliation: Department of Physiology and Pharmacology, Biological Science Center, Federal University of Pernambuco, Recife, PE, Brazil. adpaixao@npd.ufpe.br
authors.forename: Ana D O
authors.initials: AD
authors.lastname: Paixão
authors.forename: Flávia A
authors.initials: FA
authors.lastname: Nunes
authors.forename: Claude
authors.initials: C
authors.lastname: Léger
authors.forename: Maria L M
authors.initials: ML
authors.lastname: Aléssio
mesh_terms: D000818:Animals; D000074263:Coconut Oil; D004032:Diet; D005227:Fatty Acids / Q000008:administration & dosage* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D007668:Kidney / Q000187:drug effects*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D010938:Plant Oils / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000187:drug effects; D012965:Sodium Chloride / Q000494:pharmacology*; D013024:Soybean Oil / Q000494:pharmacology; D014868:Water Deprivation / Q000502:physiology*
chemical_list: D005227:Fatty Acids; D010938:Plant Oils; D012965:Sodium Chloride; D013024:Soybean Oil; D000074263:Coconut Oil