[Pathological study of ER and PR in osteosarcoma].
OBJECTIVE
To determine the relationship between estrogen receptor (ER), progesterone receptor (PR) and pathological characteristics of osteosarcoma.


METHODS
ER and PR were detected by streptavidin/peroxidase (SP) method immunohistochemically using the paraffin embedded tissues from 65 cases of osteosarcoma. The patients were typed and graded pathologically according to Liu Zijun's classification.


RESULTS
The positive rates of ER and PR were 40% (26/65), 32.3% (21/65) respectively. The positive particles were distributed in cytoplasm and nucleus. The positive rates of ER and PR in osteosarcoma with higher cell differentiation grade were higher than those in the tumor with lower one. The differences were statistically significant (P < 0.05). There were no relations to the pathological type.


CONCLUSIONS
ER and PR exist in osteosarcoma and their positive rates are related to the cell differentiation of osteosarcoma.
Liu
J
J
Department of Orthopaedics, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003.
Le
X
X
Li
Y
Y
D001859:Bone Neoplasms / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012516:Osteosarcoma / Q000737:chemistry / Q000473:pathology*; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone