Using salivary glands as a tissue target for gene therapeutics.
Gene transfer offers a potential way to correct local and systemic protein deficiency disorders by using genes as drugs, so called gene therapeutics. Salivary glands present an interesting target site for gene therapeutic applications. Herein, we review proofs of concept achieved for salivary glands with in vivo animal models. In that context we discuss problems (general and salivary tissue-specific) that limit immediate clinical use for this application of gene transfer. Ongoing efforts, however, suggest that salivary glands may be suitable as gene therapeutic target sites for drug delivery in the near future.
Hoque
A T
AT
Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892-1190, USA.
Yamano
S
S
Baccaglini
L
L
Baum
B J
BJ
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D023421:Models, Animal; D009928:Organ Specificity; D021381:Protein Transport; D012469:Salivary Glands / Q000378:metabolism*; D019076:Transgenes / Q000235:genetics*