title: [Nitrullin -- a new original Russian drug of the nitrosomethylurea group].
abstract: Hematologic thrombopenia and leukopenia formation limits use of nitrullin as a toxic hazard. The drug showed moderate effect in treating inoperable non-small cell cancer of the lung and satisfactory end results. The treatment had marked symptomatic effect in patients with this cancer and, as a consequence, improved the quality of life. Nutrullin had immuno-modulating effect. Its application alone or in combination with VPN showed good results in the management of small-cell cancer of the lung.
authors.affiliation: N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.
authors.forename: V A
authors.initials: VA
authors.lastname: Gorbunova
authors.forename: N F
authors.initials: NF
authors.lastname: Orel
authors.forename: O V
authors.initials: OV
authors.lastname: Semina
authors.forename: N S
authors.initials: NS
authors.lastname: Besova
authors.forename: Z G
authors.initials: ZG
authors.lastname: Kadagidze
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000401:mortality; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000401:mortality; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality; D002956:Citrulline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009607:Nitrosourea Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; C107500:nitrullin; D002956:Citrulline