title: Neurotensin analogs indications for use as potential antipsychotic compounds.
abstract: This review will be an update, focusing on the central nervous system (CNS) roles of the neurotransmitter, neurotensin. We will provide a summary of current knowledge about neurotensin, why it is an important peptide to study, and where the field is heading. Special emphasis is placed on the development of neurotensin analogs, which has been a major effort of our group, the potential role of neurotensin in Parkinson's disease, and the interaction of neurotensin with other neurotransmitters as evidenced by microdialysis studies.
authors.affiliation: Laboratory of Neuropharmacology, Mayo Foundation for Medical and Educational Research, Jacksonville, FL 32224, USA. McMahon.beth@mayo.edu
authors.forename: Beth M
authors.initials: BM
authors.lastname: McMahon
authors.forename: Mona
authors.initials: M
authors.lastname: Boules
authors.forename: Lewis
authors.initials: L
authors.lastname: Warrington
authors.forename: Elliott
authors.initials: E
authors.lastname: Richelson
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001812:Blood-Brain Barrier; D006801:Humans; D017551:Microdialysis; D009496:Neurotensin / Q000031:analogs & derivatives* / Q000502:physiology / Q000627:therapeutic use; D010300:Parkinson Disease / Q000188:drug therapy / Q000209:etiology; D018028:Receptors, Neurotensin / Q000032:analysis / Q000502:physiology; D012559:Schizophrenia / Q000188:drug therapy / Q000209:etiology
chemical_list: D014150:Antipsychotic Agents; D018028:Receptors, Neurotensin; D009496:Neurotensin