title: Automated assignment of SCOP and CATH protein structure classifications from FSSP scores.
abstract: We present an automated procedure to assign CATH and SCOP classifications to proteins whose FSSP score is available. CATH classification is assigned down to the topology level, and SCOP classification is assigned to the fold level. Because the FSSP database is updated weekly, this method makes it possible to update also CATH and SCOP with the same frequency. Our predictions have a nearly perfect success rate when ambiguous cases are discarded. These ambiguous cases are intrinsic in any protein structure classification that relies on structural information alone. Hence, we introduce the "twilight zone for structure classification." We further suggest that to resolve these ambiguous cases, other criteria of classification, based also on information about sequence and function, must be used.
authors.affiliation: Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Gad
authors.initials: G
authors.lastname: Getz
authors.forename: Michele
authors.initials: M
authors.lastname: Vendruscolo
authors.forename: David
authors.initials: D
authors.lastname: Sachs
authors.forename: Eytan
authors.initials: E
authors.lastname: Domany
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D000818:Animals; D001331:Automation; D030562:Databases, Protein; D020407:Internet; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000145:classification*; D015203:Reproducibility of Results; D016415:Sequence Alignment
chemical_list: D011506:Proteins