title: N2,N2,7-trimethylguanine, a new trimethylated guanine natural product from the New Zealand ascidian, Lissoclinum notti.
abstract: From the New Zealand ascidian, Lissoclinum notti a new natural product, N2,N2,7-trimethylguanine (1) has been isolated. The structure of 1 was elucidated by analysis of spectroscopic data.
authors.affiliation: Department of Chemistry, School of Environmental and Marine Science, University of Auckland, New Zealand.
authors.forename: A N
authors.initials: AN
authors.lastname: Pearce
authors.forename: R C
authors.initials: RC
authors.lastname: Babcock
authors.forename: G
authors.initials: G
authors.lastname: Lambert
authors.forename: B R
authors.initials: BR
authors.lastname: Copp
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D001943:Breast Neoplasms; D016203:CDC2 Protein Kinase / Q000378:metabolism; D017489:CDC28 Protein Kinase, S cerevisiae / Q000378:metabolism; D002176:Candida albicans / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D008175:Lung Neoplasms; D013058:Mass Spectrometry; D051379:Mice; D015394:Molecular Structure; D009423:Nervous System Neoplasms; D009520:New Zealand; D012313:RNA / Q000502:physiology; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D014249:Trichophyton / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; C446958:N(2),N(2),7-trimethylguanine; D006147:Guanine; D012313:RNA; D016203:CDC2 Protein Kinase; D017489:CDC28 Protein Kinase, S cerevisiae