title: Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model system.
abstract: A significant difference in blood-acetaldehyde concentration was observed between high alcohol-preference (HAP) rats and low alcohol-preference (LAP) rats, newly developed different alcohol preference lines. This difference of acetaldehyde accumulation may be due to cytosolic aldehyde dehydrogenase (ALDH1) polymorphism, which has been reported previously. As the doses of ethanol we employed are higher than that of voluntary drinking, there may be little direct relationship between acetaldehyde accumulation and alcohol preference. We suggest therefore that the ALDH1 polymorphism is associated with alcohol preference in HAP/LAP lines through some other unidentified mechanism.
authors.affiliation: Department of Legal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501 Japan.
authors.forename: Minori
authors.initials: M
authors.lastname: Nishiguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Jamal
authors.initials: J
authors.lastname: Mostofa
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Harumi
authors.initials: H
authors.lastname: Ouchi
authors.forename: Takako
authors.initials: T
authors.lastname: Minami
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Hatake
authors.forename: Takao
authors.initials: T
authors.lastname: Utsumi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Motomura
authors.forename: Shigeru
authors.initials: S
authors.lastname: Hishida
mesh_terms: D000079:Acetaldehyde / Q000097:blood*; D000428:Alcohol Drinking / Q000235:genetics; D000437:Alcoholism / Q000097:blood / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D000080924:Aldehyde Dehydrogenase 1 Family; D000818:Animals; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005518:Food Preferences; D007527:Isoenzymes / Q000235:genetics; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D050697:Retinal Dehydrogenase; D012641:Selection, Genetic
chemical_list: D002492:Central Nervous System Depressants; D007527:Isoenzymes; D000431:Ethanol; D000080924:Aldehyde Dehydrogenase 1 Family; D000444:Aldehyde Dehydrogenase; C515028:ALDH1A1 protein, mouse; C523119:Aldh1a1 protein, rat; D050697:Retinal Dehydrogenase; D000079:Acetaldehyde