Limits to lifespan.
It has long-been accepted that normal somatic cells have intrinsic mechanisms that limit their proliferative lifespan. Recent work has now challenged this view by demonstrating that extrinsic factors might be determining proliferative potential.
Lloyd
Alison C
AC
Cancer Research Campaign, MRC Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK. alison.lloyd@ucl.ac.uk
D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods*; D002455:Cell Division / Q000502:physiology*; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000502:physiology*; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D006801:Humans; D010641:Phenotype; D015398:Signal Transduction / Q000502:physiology; D019098:Telomerase / Q000378:metabolism
D019098:Telomerase