Glomerulonephritis after recombinant hepatitis B vaccine.
Renal complications after vaccination with hepatitis B recombinant vaccine are rare; very few cases are reported without a histopathologic definition. We describe a case of glomerulonephritis in a 12-year-old girl, beginning after the inoculation of hepatitis B vaccine. The immunohistochemical examination of her renal biopsy, with the use of monoclonal antibodies, shows the presence of hepatitis B surface antigen in renal tissue. After 2 years chronic glomerulonephritis persisted and was treated with angiotensin-converting enzyme inhibitors. After 3 years of follow-up, the renal disease was in remission, and treatment was stopped.
Pennesi
Marco
M
Department of Pediatrics, IRCCS Burlo Garofolo Children's Hospital, Trieste, Italy. pennesi@burlo.trieste.it
Torre
Giuliano
G
Del Santo
Manuela
M
Sonzogni
Aurelio
A
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000911:Antibodies, Monoclonal; D001706:Biopsy; D002648:Child; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000276:immunology / Q000473:pathology
D000806:Angiotensin-Converting Enzyme Inhibitors; D000911:Antibodies, Monoclonal; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines