Relative impact of low-density lipoprotein-cholesterol concentration and insulin resistance on carotid wall thickening in nondiabetic, normotensive volunteers.
The relative effect of an increase in low-density lipoprotein-cholesterol (LDL-C) concentration, as compared with insulin resistance and its manifestations, on intimal medial thickening (IMT) of the common carotid artery was defined in 72 healthy men and women. Insulin-mediated glucose disposal was quantified by the insulin suppression tests, in which the height of the steady-state plasma glucose (SSPG) concentration during the last 30 minutes of a 180-minute infusion of octreotide, insulin, and glucose provides an estimate of insulin resistance. IMT was determined by high-resolution B-mode ultrasonography. Univariate analyses defined statistically significant correlation coefficients between IMT and LDL-C concentration (r =.25, P <.05), SSPG concentration (r =.32, P <.01), triglycerides (TG) (r =.25, P <.05), and high-density lipoprotein-cholesterol (HDL-C) (r = -.28, P <.05) concentrations (changes associated with insulin resistance) and ratio of waist-to-hip girth (r =.29, P <.05). When forward step-wise linear regression analysis was used, concentrations of SSPG, LDL-C and HDL-C all emerged as independent predictors of IMT (P <.05). Furthermore, the magnitude of their relationship to IMT values was comparable. These results provide evidence that insulin resistance is as significant a predictor of degree of atherogenesis (estimated by IMT) of the common carotid artery as a high LDL-C concentration.
Wang
Pei-Wen
PW
Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC.
Liou
Chia-Wei
CW
Wang
Shan-Tair
ST
Eng
Hock-Liow
HL
Liu
Rue-Tsuan
RT
Tung
Shih-Chen
SC
Chien
Wen-Yen
WY
Lu
Yung-Chuan
YC
Kuo
Ming-Chun
MC
Hsieh
Ching-Jung
CJ
Chen
Cheng-Hsiung
CH
Chen
Jung-Fu
JF
Chu
James W
JW
Reaven
Gerald M
GM
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002339:Carotid Arteries / Q000473:pathology*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D003920:Diabetes Mellitus / Q000473:pathology; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D012016:Reference Values; D017539:Tunica Intima / Q000473:pathology*
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL