Manganese superoxide dismutase genotypes and asbestos-associated pulmonary disorders.
Manganese superoxide dismutase (MnSOD) activity is highly elevated in the biopsies of human asbestos-associated malignant mesothelioma. We therefore examined if polymorphism in the mitochondrial targeting sequence of the MnSOD gene modified individual susceptibility to this malignancy or related asbestos-associated pulmonary disorders. The study population consisted of 124 male Finnish asbestos insulators who were all classified as having been exposed to high levels of asbestos; 63 of the workers had no pulmonary disorders and 61 either had malignant mesothelioma or the non-malignant pulmonary disorders asbestosis and/or pleural plaques. No significant associations were found between the MnSOD genotypes and these ill-health. This study therefore suggest no major modifying role for the MnSOD polymorphism in development of asbestos-associated pulmonary disorders.
Hirvonen
Ari
A
Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, FIN-00250 Helsinki, Finland. ari.hirvonen@occuphealth.fi
Tuimala
Jarno
J
Ollikainen
Tiina
T
Linnainmaa
Kaija
K
Kinnula
Vuokko
V
D001194:Asbestos / Q000009:adverse effects*; D001195:Asbestosis / Q000201:enzymology* / Q000209:etiology / Q000235:genetics; D015331:Cohort Studies; D017931:DNA Primers / Q000737:chemistry; D005260:Female; D005838:Genotype; D006801:Humans; D008214:Lymphocytes / Q000502:physiology; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced / Q000201:enzymology* / Q000235:genetics; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D010997:Pleural Neoplasms / Q000139:chemically induced / Q000201:enzymology* / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics*
D017931:DNA Primers; D001194:Asbestos; D013482:Superoxide Dismutase