Protein transduction technology.
Intracellular delivery of macromolecules remains problematic because of the bioavailability restriction imposed by the cell membrane. Recent studies on protein transduction domains have circumvented this barrier, however, and have resulted in the delivery of peptides, full-length proteins, iron beads, liposomes, and radioactive isotopes into cells in culture and animal models in vivo.
Wadia
Jehangir S
JS
Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0686, USA.
Dowdy
Steven F
SF
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D017434:Protein Structure, Tertiary; D021381:Protein Transport