[Chrono-pharmacodynamics of capoten in patients with ischemic heart disease, postinfarction cardiosclerosis with cardiac failure].
Hemodynamic parameters were measured before and 30 min, 1, 2 and 3 hours after intake of 12.5 mg capoten in acute pharmacological test at 7.00, 10.00, 13.00, 16.00, 19.00 and 22.00 in 70 patients with ischemic heart disease, postinfarction cardiosclerosis with heart failure stage I-II. The patients were randomized into 6 groups according to the time of the pharmacological test. As shown by tetrapolar chest rheography, the lowest peripheral vascular resistance and the highest cardiac ejection occurred if capoten was used at 10.00. In contrast, vascular resistance rose and cardiac ejection fell in capoten intake at 13.00. At the other hours circulation responded more favourably than at 13.00 but not so strongly as at 10.00. Different hemodynamic reaction to capoten within 24 hours demands further studies.
Zaslavskaia
R M
RM
Zhamankulov
K Zh
KZh
Akhmetova
A S
AS
Teĭblium
M M
MM
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use*; D002909:Chronobiology Phenomena; D005260:Female; D006331:Heart Diseases / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D017202:Myocardial Ischemia / Q000188:drug therapy*; D012598:Sclerosis / Q000188:drug therapy / Q000473:pathology
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril