title: Comparison of normal saline and heparinized saline for patency of IV locks in neonates.
abstract: In this randomized double-blind experiment of 49 neonatal intensive care unit patients, probable time to catheter failure was significantly longer (p =.0358) for catheters flushed with heparinized saline (median = 127) compared with those flushed with normal saline (median = 39). This is in contrast to the nonsignificant difference (p =.841) in mean scores for six heparin-flushed catheters (M = 41.5 hours, SD = 44.0) compared with 18 saline-flushed catheters (M = 30.4 hours, SD = 20.8) discontinued for reasons other than completion of treatment. We concluded that survival time analysis is necessary when evaluating results of time-dependent studies in which the end point may not be elective.
authors.affiliation: Maine Medical Center, Portland, ME 04102, USA. schula@mmc.org
authors.forename: Alyce A
authors.initials: AA
authors.lastname: Schultz
authors.forename: Debra
authors.initials: D
authors.lastname: Drew
authors.forename: Hilary
authors.initials: H
authors.lastname: Hewitt
mesh_terms: D000925:Anticoagulants; D002404:Catheterization / Q000295:instrumentation* / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D006493:Heparin; D006801:Humans; D007231:Infant, Newborn; D007362:Intensive Care Units; D008297:Male; D012965:Sodium Chloride
chemical_list: D000925:Anticoagulants; D012965:Sodium Chloride; D006493:Heparin