Amino(hydroxymethyl)cyclopentanetriols, an emerging class of potent glycosidase inhibitors--Part I: Synthesis and evaluation of beta-D-pyranoside analogues in the manno, gluco, galacto, and GlcNAc series.
Kleban
M
M
Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany.
Hilgers
P
P
Greul
J N
JN
Kugler
R D
RD
Li
J
J
Picasso
S
S
Vogel
P
P
Jäger
V
V
D000117:Acetylglucosamine / Q000737:chemistry; D000606:Amino Sugars / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005690:Galactose / Q000737:chemistry; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006027:Glycosides / Q000737:chemistry; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008358:Mannose / Q000737:chemistry; D013329:Structure-Activity Relationship
D000606:Amino Sugars; D003517:Cyclopentanes; D004791:Enzyme Inhibitors; D006027:Glycosides; C013904:cyclopentane-1,2,3-triol; D006026:Glycoside Hydrolases; D008358:Mannose; D000117:Acetylglucosamine; D005690:Galactose