Th1 cytokines in autoimmune thyroiditis.
This study was performed on a lot of 51 patients and intends to correlate the autoimmune thyroiditis to the synthesis of Th1 cytokines and to the activation of T lymphocytes. We find out that CD25, an activation marker of T lymphocytes, is significantly increased in these patients. We also find out that certain cytokine serum levels are increased (IL-2, TNF-alpha, IFN-gamma). These cytokines correspond to the secretor profile of the Th1 subset. Mononuclear cell culture supernatants showed an increased level of IL-2 and TNF-alpha in samples stimulated with ConA in comparison to unstimulated samples from the same patient, suggesting the existence of an expansioned Th1 and CD8+ cytotoxic population.
Drugărin
D
D
Department of Immunology, University of Medicine and Pharmacy, Timişoara, Romania.
Negru
S
S
Koreck
A
A
D000293:Adolescent; D000328:Adult; D003208:Concanavalin A; D016207:Cytokines / Q000032:analysis* / Q000097:blood; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000032:analysis; D018417:Th1 Cells / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000276:immunology*
D016207:Cytokines; D015375:Receptors, Interleukin-2; D003208:Concanavalin A