High serum concentrations of dimeric inhibins A and B in normal newborn girls.
OBJECTIVE
To establish the serum pattern of dimeric inhibins in normal girls during the newborn period and to examine its relationship with the postnatal gonadotropic surge.


METHODS
Retrospective study. SETTING; Division of endocrinology of a children's hospital.


METHODS
Thirty-one girls 4 to 65 days of age.


METHODS
Serum levels of FSH, LH, and inhibin A and B.


RESULTS
High serum concentrations of both dimeric inhibins were detected during the first weeks of life. Concentrations tended to decrease through the second month of age. Inhibin A and B concentrations positively correlated with age only during the first 2 weeks of life (r =.57, P<.05 and r =.70, P<.01, respectively). Inhibin A and B were positively and significantly correlated with LH (r =.57, P<.05 and r =.52, P<.05, respectively) and with each other (r =.68, P<.0001). No correlation was found between dimeric inhibins and FSH.


CONCLUSIONS
The high inhibin concentrations observed in newborn girls, which indicate advanced follicular development and granulosa cell differentiation, may be useful markers for congenital gonadal disorders.
Bergadá
Ignacio
I
Centro de Investigaciones Endocrinológicas, R. Gutierrez Hospital de Niños, Gallo 1330, 1425 Buenos Aires, Argentina. ibergada@cedie.guti.gov.ar
Ballerini
Gabriela M
GM
Ayuso
Sandra
S
Groome
Nigel P
NP
Bergadá
César
C
Campo
Stella
S
D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015200:Fluoroimmunoassay; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000097:blood*; D007265:Inhibins / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
C422362:inhibin A; C422364:inhibin B; D007265:Inhibins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone