A facile one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones.
An efficient and practical one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones has been achieved from 1,2-diarylethanones and 2-bromoisobutyryl cyanide in the presence of excess base, by employing the 'hard soft acid base' principle. The reaction scope of 2-bromoisobutyryl cyanide could be expanded to prepare a variety of 2,2-dimethyl-3(2H)-furanone derivatives other than 4,5-diaryl-2,2-dimethyl-3(2H)-furanones.
Lee
Ki-Wha
KW
Drug Discovery, Pacific Corporation R&D Center, 314-1 Bora-ri, Kiheung-eup, Yongin-si, 449-729, Kyounggi-do, South Korea.
Choi
Young Hoon
YH
Joo
Yung Hyup
YH
Kim
Jin Kwan
JK
Shin
Song Seok
SS
Byun
Young Joo
YJ
Kim
Yeonjoon
Y
Chung
Shin
S
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis; D005663:Furans / Q000138:chemical synthesis*; D007659:Ketones
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D005663:Furans; D007659:Ketones