Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala.
The behavioral effects of direct injection of the neuropeptide Y (NPY) Y2 receptor agonist C2-NPY into the basolateral nucleus of the amygdala (BLA) was assessed in rats utilizing the social interaction test (SI). C2-NPY decreased SI time in a dose-dependent manner with a significant change observed at a dose of 80 pmol/100 nl. The anxiogenic effects produced by intra-amygdalar C2-NPY injections were reversed with intraperitoneal administration of alprazolam (1 mg/kg), a known anxiolytic. These findings support the hypothesis that Y2 receptors are involved in the regulation of the anxiety response.
Sajdyk
Tammy J
TJ
Indiana University Medical Center, Indianapolis, IN 46202, USA.
Schober
Douglas A
DA
Smiley
David L
DL
Gehlert
Donald R
DR
D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D007398:Interpersonal Relations; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017476:Receptors, Neuropeptide Y / Q000819:agonists / Q000502:physiology*
D017476:Receptors, Neuropeptide Y; C095889:neuropeptide Y2 receptor