Comparison between pediatric acute myeloid leukemia (AML) and adult AML in VEGF and KDR (VEGF-R2) protein levels.
We reported previously that high levels of vascular endothelial growth factor (VEGF) were associated with shorter survival in adult acute myeloid leukemia (AML) patients. In this study, cellular VEGF and its receptor, VEGF-R2 (kinase domain receptor (KDR)), were analyzed in 45 pediatric AML patients using Western blot and solid-phase radioimmunoassay (RIA). Cellular VEGF levels were significantly lower in pediatric AML compared to adult AML patients. In contrast, there was no significant difference in VEGF-R2 levels between adult and pediatric AML. Higher VEGF and VEGF-R2 levels in pediatric AML patients correlated with higher white blood cell (WBC). Unlike in adults, VEGF and VEGF-R2 levels in pediatric AML patients did not correlate with survival. This data suggest that the role of VEGF and its receptor VEGF-R2 in pediatrics AML may be different from that in adult AML.
Jeha
Sima
S
Department of Pediatrics, University of Texas, M.D. Anderson Cancer Center, P.O. Box 072, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Smith
Franklin O
FO
Estey
Elihu
E
Shen
Yu
Y
Liu
Diane
D
Manshouri
Taghi
T
Albitar
Maher
M
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001853:Bone Marrow / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D016228:Endothelial Growth Factors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D007951:Leukemia, Myeloid / Q000378:metabolism* / Q000503:physiopathology; D008222:Lymphokines / Q000378:metabolism*; D008297:Male; D011379:Prognosis; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D017978:Receptors, Growth Factor / Q000378:metabolism*; D040262:Receptors, Vascular Endothelial Growth Factor; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D017978:Receptors, Growth Factor; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D020794:Receptor Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor