title: Radiation therapy and combination of cladribine, cyclophosphamide, and prednisone as treatment of Bing-Neel syndrome: Case report and review of the literature.
abstract: Waldenström's macroglobulinemia is a low-grade lymphoma that produces monoclonal IgM. Central nervous system symptoms are frequent in Waldenström's macroglobulinemia, mostly associated with blood hyperviscosity. Nevertheless, central nervous system infiltration by malignant cells (Bing-Neel syndrome) has rarely been reported. We describe the case of a 72-year-old man with Waldenstrom's macroglobulinemia and central nervous system infiltration by malignant cells with tumor formation. All similar cases reported in the literature are reviewed and the different therapeutic approaches discussed.
authors.affiliation: Department of Hematology, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Julio
authors.initials: J
authors.lastname: Delgado
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Canales
authors.forename: Beatriz
authors.initials: B
authors.lastname: Garcia
authors.forename: Javier
authors.initials: J
authors.lastname: Alvarez-Ferreira
authors.forename: Antonio
authors.initials: A
authors.lastname: Garcia-Grande
authors.forename: Fernando
authors.initials: F
authors.lastname: Hernandez-Navarro
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D001921:Brain / Q000473:pathology*; D017338:Cladribine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004244:Dizziness; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D018908:Muscle Weakness; D011241:Prednisone / Q000627:therapeutic use; D013238:Stereotaxic Techniques; D008258:Waldenstrom Macroglobulinemia / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000628:therapy*
chemical_list: D005938:Glucocorticoids; D007075:Immunoglobulin M; D017338:Cladribine; D003520:Cyclophosphamide; D011241:Prednisone