Feedback regulation of pancreatic secretion by peptide YY.
The present status of our understanding of the feedback regulation of pancreatic secretion by peptide YY (PYY) released from the distal intestine is reviewed. Exocrine pancreatic secretion is primarily controlled by the cephalic (the vagus nerve), gastric (acid and pepsin secretion, and nutrients delivered into the duodenum by gastric emptying), and intestinal (secretin and CCK) mechanisms. PYY acts on the multiple sites in the brain and gut, and inhibits pancreatic secretion by regulating these primary control mechanisms. The involvement of Y(1) and Y(2) receptors has been suggested in the regulation of pancreatic secretion. However, it remains to be studied which site of action or receptor subtype is physiologically most important for this regulation.
Naruse
Satoru
S
Internal Medicine II, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. snaruse@med.nagoya-u.ac.jp
Kitagawa
Motoji
M
Ishiguro
Hiroshi
H
Hayakawa
Tetsuo
T
D000818:Animals; D001921:Brain / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism*; D019894:Peptide YY / Q000378:metabolism* / Q000502:physiology; D013997:Time Factors
D019894:Peptide YY