New indene-derivatives with anti-proliferative properties.
Metabolites of the non-steroidal anti-inflammatory drug Sulindac inhibit cell proliferation by affecting several intracellular signaling pathways including the tumorigenic Ras/Raf/MAPK pathway. Here, we report the synthesis of eight new indene derivatives derived from the Sulindac structure, and present data on their anti-proliferative properties and their effects on the p21ras protein.
Karaguni
Ioanna-Maria
IM
Max-Planck-Institut fur Molekulare Physiologie, Dortmund, Germany.
Glüsenkamp
Karl-Heinz
KH
Langerak
Anette
A
Geisen
Christoph
C
Ullrich
Volker
V
Winde
Günther
G
Möröy
Tarik
T
Müller
Oliver
O
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D004285:Dogs; D006801:Humans; D007192:Indenes / Q000138:chemical synthesis / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D051379:Mice; D015689:Oncogene Protein p21(ras) / Q000037:antagonists & inhibitors / Q000187:drug effects; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects; D013467:Sulindac / Q000031:analogs & derivatives*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D016861:Cyclooxygenase Inhibitors; D007192:Indenes; D013467:Sulindac; D011451:Prostaglandin-Endoperoxide Synthases; D015689:Oncogene Protein p21(ras)