Effects of chronic administration of huperzine A on memory in guinea pigs.
Effects of subchronic administration of huperzine A, a cholinesterase inhibitor, on spatial memory were studied in guinea pig. Spatial memory was appreciated by the Morris water maze test. At a dose of 0.25 microgram/h, inhibiting 36% of blood AChE and 14-20% of central AChE, no effect on spatial learning was found. At a dose of 1 microgram/h, inhibiting 20% of blood AChE and 14-20% of central AChE, no memory impairment was found, on the other hand, a memory enhancing effect, limited to the first day was shown. It thus appears that subchronic administration of huperzine A did not induce deleterious effects on spatial memory.
Filliat
Pierre
P
Unité de Neuropharmacologie, CRSSA, 24, avenue des Maquis du Grésivaudan, BP 87, 38702, La Tronche Cedex, France. 100437.201@compuserve.com
Foquin
Annie
A
Lallement
Guy
G
D000110:Acetylcholinesterase / Q000187:drug effects / Q000378:metabolism; D000470:Alkaloids; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D012717:Sesquiterpenes; C050426:huperzine A; D000110:Acetylcholinesterase