[Current results and perspectives of the use of human tumor cell lines for antitumor drug screening].
Cytotoxic screening of 2,000 chemical compounds against human tumor cell lines has identified certain antimetabolities, platinum complexes, actinomycin D derivatives and somatostatin analogs as possible antitumor agents. Differential sensitivity of such lines derived from five cancers (lung, colon, ovary, breast and leukemia) to certain antitumor agents has been established. This panel of cell lines is currently employed as a model for in vitro drug screening to identify biological response profile at earlier stages.
Zhukova
O S
OS
N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.
Dobrynin
Ia V
IaV
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D003110:Colonic Neoplasms / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D010051:Ovarian Neoplasms / Q000188:drug therapy; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000970:Antineoplastic Agents