The structure of diversity within New World mitochondrial DNA haplogroups: implications for the prehistory of North America.
The mitochondrial DNA haplogroups and hypervariable segment I (HVSI) sequences of 1,612 and 395 Native North Americans, respectively, were analyzed to identify major prehistoric population events in North America. Gene maps and spatial autocorrelation analyses suggest that populations with high frequencies of haplogroups A, B, and X experienced prehistoric population expansions in the North, Southwest, and Great Lakes region, respectively. Haplotype networks showing high levels of reticulation and high frequencies of nodal haplotypes support these results. The haplotype networks suggest the existence of additional founding lineages within haplogroups B and C; however, because of the hypervariability exhibited by the HVSI data set, similar haplotypes exhibited in Asia and America could be due to convergence rather than common ancestry. The hypervariability and reticulation preclude the use of estimates of genetic diversity within haplogroups to argue for the number of migrations to the Americas.
Malhi
Ripan S
RS
Department of Human Genetics, 3726 Medical Science II, University of Michigan, 1301 E. Catherine Street, Ann Arbor, MI 48109-0618, USA. malhi@umich.edu
Eshleman
Jason A
JA
Greenberg
Jonathan A
JA
Weiss
Deborah A
DA
Schultz Shook
Beth A
BA
Kaestle
Frederika A
FA
Lorenz
Joseph G
JG
Kemp
Brian M
BM
Johnson
John R
JR
Smith
David Glenn
DG
D004272:DNA, Mitochondrial / Q000235:genetics*; D004641:Emigration and Immigration; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D009656:North America
D004272:DNA, Mitochondrial