Bone marrow necrosis and refractory HELLP syndrome in a patient with catastrophic antiphospholipid antibody syndrome.
We describe a 22-year-old woman who developed extensive and fatal bone marrow necrosis along with involvement of liver, lung, and central nervous system during pregnancy in the background of very high titers of antiphospholipid and anti-beta2 glycoprotein antibodies. This case illustrates a rarely recognized, potentially fatal complication of aPL in the setting of pregnancy.
Sinha
Jayashree
J
Albert Einstein College of Medicine and White Plains Medical Center Bronx New York, USA.
Chowdhry
Iftikhar
I
Sedan
Sarah
S
Barland
Peter
P
D000028:Abortion, Induced; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D001157:Arterial Occlusive Diseases / Q000209:etiology / Q000473:pathology; D001855:Bone Marrow Diseases / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D002388:Catastrophic Illness; D002544:Cerebral Infarction / Q000209:etiology / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D017359:HELLP Syndrome / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009336:Necrosis; D011247:Pregnancy