title: Malignant fibrous histiocytoma associated with a meningothelial meningioma.
abstract: A 72-year-old woman was operated for a left parietal tumor of the meninges. The symptomatology began 22 years earlier with a right hemiparesis. The histological examination of the tumor showed a proliferation of meningothelial cells with whorl formation, associated with a pleomorphic proliferation of a malignant fibrous histiocytoma. The meningothelial meningioma showed a typical aspect, with nuclear inclusions and absence of mitotic activity. The second tumor component showed a storiform architecture with giant multinucleated cells, necrosis and many typical and atypical mitoses. There was also an inflammatory component with infiltrates of lymphocytes. This tumor component at the border with the meningioma appeared to arise from the septa of the meningioma with many prongs merging into one large and pleomorphic histiocytomatous tumor. The dual histological aspect and the case are discussed in the light of what is already known in the literature. The woman has been irradiated after surgery and she is doing well 6 months after operation.
authors.affiliation: Department of Neuroscience, University of Turin, Italy. davide.schiffer@unito.it
authors.forename: D
authors.initials: D
authors.lastname: Schiffer
authors.forename: A
authors.initials: A
authors.lastname: Ferraiolo
authors.forename: V
authors.initials: V
authors.lastname: Fiano
authors.forename: A
authors.initials: A
authors.lastname: Romano
mesh_terms: D000368:Aged; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006801:Humans; D008577:Meningeal Neoplasms / Q000473:pathology*; D008579:Meningioma / Q000473:pathology*