title: Preincisional bupivacaine in posttonsillectomy pain relief: a randomized prospective study.
abstract: OBJECTIVE
  To determine the effect of preincisional bupivacaine hydrochloride infiltration on postoperative pain after tonsillectomy.
  
  
  METHODS
  Prospective, randomized, double-blind clinical trial.
  
  
  METHODS
  A secondary/tertiary referral center in Christchurch, New Zealand.
  
  
  METHODS
  A volunteer sample of 70 patients, aged 16 to 42 years, with recurrent tonsillitis. Seven patients were excluded.
  
  
  METHODS
  After randomization, one group received 5 mL of 0.5% bupivacaine hydrochloride in the peritonsillar space, with the patient under general anesthesia. The other group received 5 mL of isotonic sodium chloride solution, with the patient under general anesthesia. Both groups underwent surgery with a standardized surgical and anesthetic technique.
  
  
  METHODS
  Postoperative pain was assessed with a visual analog scale at 15 minutes and 1, 4, 12, 16, and 24 hours after the procedure. Postoperative analgesic requirement, length of admission, and antiemetic requirement were also assessed.
  
  
  RESULTS
  No statistical difference was found between the 2 groups for postoperative pain by means of the visual analog scale at any time interval, nor was any statistical difference found for the other variables measured. A trend toward less pain in the immediate postoperative period in the group receiving bupivacaine was noted.
  
  
  CONCLUSIONS
  No statistically significant benefit is found for use of preincisional bupivacaine in tonsillectomy.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Glasgow Royal Infirmary, 84 Castle St, Glasgow G4 0SF, Scotland, UK. nileshvasan@aol.com
authors.forename: Nilesh Raman
authors.initials: NR
authors.lastname: Vasan
authors.forename: Scott
authors.initials: S
authors.lastname: Stevenson
authors.forename: Mark
authors.initials: M
authors.lastname: Ward
mesh_terms: D000293:Adolescent; D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000627:therapeutic use; D002045:Bupivacaine / Q000008:administration & dosage* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007322:Instillation, Drug; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology*; D011229:Preanesthetic Medication; D011446:Prospective Studies; D013997:Time Factors; D014068:Tonsillectomy / Q000009:adverse effects*
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine