title: pH Homeostasis of cellular organelles.
abstract: An optimal pH is maintained in each secretory and endocytic organelle by the balance between active H(+) pumping and passive H(+) efflux. The progressive acidification of secretory organelles does not reflect an increased proton pumping activity but rather the decreased conduction of a "proton leak" pathway resembling the recently cloned voltage-gated proton channels.
authors.affiliation: Department of Physiology, University of Geneva, 1211 Geneva 4, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Demaurex
mesh_terms: D000818:Animals; D006863:Hydrogen-Ion Concentration; D015388:Organelles / Q000378:metabolism*; D011522:Protons
chemical_list: D011522:Protons