title: Synthesis and pharmacological analysis of high affinity melatonin receptor ligands.
abstract: We report the synthesis and radioligand binding analysis of a series of naphthalenic melatonin receptor ligands, N-[2-(7-alkoxy-2-methoxy-1-naphthyl)ethyl]propionamide. This series of ligands exhibits subpicomolar binding affinity to both MT1 and MT2 melatonin receptors expressed in chinese hamster ovary (CHO) cells.
authors.affiliation: Department of Medicinal Chemistry and Pharmaceutics, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA, 15282, USA.
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Chu
authors.forename: Paula A
authors.initials: PA
authors.lastname: Witt-Enderby
authors.forename: Marla
authors.initials: M
authors.lastname: Jones
authors.forename: L
authors.initials: L
authors.lastname: Pui-Kai
mesh_terms: D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D011869:Radioligand Assay; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D044094:Receptors, Melatonin
chemical_list: D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D044094:Receptors, Melatonin