title: Synthesis of allenes from allylic alcohol derivatives bearing a bromine atom using a palladium(0)/diethylzinc system.
abstract: A general and efficient synthesis of allenes using a palladium(0)/diethylzinc system is described. Treatment of mesylates or trichloroacetates of (E)- or (Z)-2-bromoalk-2-en-1-ols with diethylzinc in the presence of a catalytic amount of palladium(0) affords allenes bearing an aminoalkyl, alkyl, or aryl substituent(s) in good to high yields. No transfer of chirality from the stereogenic center carrying the mesyloxy group to the allene was observed.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ohno
authors.forename: Kumiko
authors.initials: K
authors.lastname: Miyamura
authors.forename: Tetsuaki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Shinya
authors.initials: S
authors.lastname: Oishi
authors.forename: Ayako
authors.initials: A
authors.lastname: Toda
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Takemoto
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Fujii
authors.forename: Toshiro
authors.initials: T
authors.lastname: Ibuka