title: Relapse of hyperprolactinemia after transsphenoidal surgery for microprolactinoma: lessons from long-term follow-up.
abstract: OBJECTIVE
  The long-term results of transsphenoidal surgery for microprolactinoma, with particular reference to the question of permanence of relapse of hyperprolactinemia after biochemical cure, are examined.
  
  
  METHODS
  Patients whose operations were performed in the city of Glasgow, Scotland, by one neurosurgeon (GMT) have been followed up for between 15 and 21 years after surgery was performed.
  
  
  RESULTS
  Of a cohort of 44 patients with confirmed microprolactinoma at the time of surgery, 8 patients (18.2%) who experienced recurrent hyperprolactinemia postoperatively continued to be monitored. Selective hypophysectomy resulted in normal prolactin levels in all patients initially. Relapse occurred at 2 to 10 years (mean, 5.3 yr) postoperatively, but was permanent in only two patients (4.5%). Of the remaining six patients (13.6%), four (9.1%) became normoprolactinemic after 6 or 7 years' recurrence, and two (4.5%) are now only marginally hyperprolactinemic (prolactin >500 but <700 mU/L) at 15 and 18 years after transsphenoidal hypophysectomy.
  
  
  CONCLUSIONS
  The recurrence of hyperprolactinemia after transsphenoidal surgery for microprolactinoma is not necessarily a permanent feature and does not inevitably indicate operative failure.
authors.affiliation: University Department of Medicine, Glasgow Royal Infirmary, Glasgow, Scotland G4 0SF, UK.
authors.forename: John A
authors.initials: JA
authors.lastname: Thomson
authors.forename: Christina E
authors.initials: CE
authors.lastname: Gray
authors.forename: Graham M
authors.initials: GM
authors.lastname: Teasdale
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006966:Hyperprolactinemia / Q000175:diagnosis / Q000601:surgery*; D007016:Hypophysectomy; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000601:surgery*; D011183:Postoperative Complications / Q000175:diagnosis*; D011388:Prolactin / Q000097:blood*; D015175:Prolactinoma / Q000175:diagnosis / Q000601:surgery*; D012008:Recurrence; D013101:Sphenoid Sinus / Q000601:surgery
chemical_list: D011388:Prolactin