Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L.
The acute LD50s of ferulenol were determined in albino mice by single po or ip as 2,100 and 319 mg/kg bw, respectively. Ferulenol had a higher LD50 compared to warfarin and thus has a lower acute toxicity. Three days after ferulenol administration, dosed animals showed hypoprothrombinemia with internal and external hemorrhages similar to those described in ferulosys and anti-vitamin K experimental poisonings. Male mice were more sensitive to intoxication by ferulenol than were females.
Fraigui
O
O
Département de Pharmacognosie, Faculté de Médecine et de Pharmacie, Rabat-lnstituts, Maroc.
Lamnaouer
D
D
Faouzi
M Y A
MY
D000284:Administration, Oral; D000818:Animals; D003374:Coumarins / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice
D003374:Coumarins; C092340:ferulenol