title: Evaluating routine diuretics after coronary surgery: a prospective randomized controlled trial.
abstract: BACKGROUND
  Routine diuretic administration after cardiopulmonary bypass is common despite the lack of evidence for its benefit. We performed a prospective study to evaluate if diuretics assist in weight loss or alter clinical outcome.
  
  
  METHODS
  Seventy-nine patients undergoing primary elective coronary bypass surgery were randomized to either diuretic (fusemide and amiloride) or placebo (lactose) postoperatively until preoperative weight was achieved or for 5 days in total. Proportions were compared with chi2 or Fisher's exact test.
  
  
  RESULTS
  Forty patients were randomized to diuretics and 39 to placebo. By day 5, 97% of patients (37 of 38) still in the diuretic arm, and 74% of patients (29 of 39) in the placebo arm, achieved preoperative weight (p = 0.02). There were no differences in clinical outcomes.
  
  
  CONCLUSIONS
  Routine diuretics promote an earlier diuresis but no clinical benefits are apparent in low risk patients with normal renal function. Clinicians should reconsider routine diuretic prescription in this setting.
authors.affiliation: Department of Cardiothoracic Surgery, Northern General Hospital, Sheffield, United Kingdom.
authors.forename: Eric
authors.initials: E
authors.lastname: Lim
authors.forename: Ziad A
authors.initials: ZA
authors.lastname: Ali
authors.forename: Robert
authors.initials: R
authors.lastname: Attaran
authors.forename: Graham
authors.initials: G
authors.lastname: Cooper
mesh_terms: D000368:Aged; D000584:Amiloride / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D004232:Diuretics / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D004232:Diuretics; D000584:Amiloride; D005665:Furosemide