In vitro antiviral effect of flavonoid-rich extracts of Vitex polygama (Verbenaceae) against acyclovir-resistant herpes simplex virus type 1.
Extracts and fractions rich in flavonoids from fruits and leaves of Vitex polygama Cham. (Verbenaceae) were tested against acyclovir-resistant herpes simplex virus type 1 (ACV-HSV-1). Both fruit and leaf extracts exhibited a dose-dependent antiviral activity. The extract from the leaves showed intracellular antiviral activity while the extract from the fruits had virucidal effect. A fraction from the ethyl actetate extract of the leaves inhibited virus propagation by blocking HEp-2 cell receptors.
Gonçalves
J L
JL
Instituto de Microbiologia Professor Paulo de Góes, Departamento de Virologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Leitão
S G
SG
Monache
F D
FD
Miranda
M M
MM
Santos
M G
MG
Romanos
M T
MT
Wigg
M D
MD
D000212:Acyclovir / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D014407:Tumor Cells, Cultured; D020950:Vitex
D000998:Antiviral Agents; D005419:Flavonoids; D010936:Plant Extracts; D000212:Acyclovir