Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin.
Numerous analogues of the naturally occurring antibiotic althiomycin have been synthesised exploiting both total- and semi-synthetic methodologies. The antibacterial activity of these derivatives has been determined in whole cell assays and indicates the natural product exhibits a restricted SAR.
Zarantonello
Paola
P
GlaxoSmithKline SpA, Medicines Research Centre, Via Fleming 4, 37135, Verona, Italy. pz29728@gsk.com
Leslie
Colin P
CP
Ferritto
Rafael
R
Kazmierski
Wieslaw M
WM
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013844:Thiazoles; C010018:althiomycin