Regulation of naïve and memory T-cell homeostasis.
Recent work has confirmed the existence of homeostatic mechanisms that regulate the overall size and composition of the mature T-cell pool. Homeostatic mechanisms not only control total T-cell numbers but appear to act differently on naïve vs. memory cells. The roles of self-MHC/peptide ligands and certain cytokines in T-cell homeostasis are discussed.
Surh
Charles D
CD
Department of Immunology, IMM26, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. csurh@scripps.edu
Sprent
Jonathan
J
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D005786:Gene Expression Regulation; D006706:Homeostasis / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*
D016207:Cytokines