title: Gene therapy: some results, many problems to solve.
abstract: Gene therapy is raising incredible hopes. The prospects of treating numbers of severe pathologies (hereditary, cancerous, degenerative or infectious) are vast. Nevertheless, the technological bolts to lift are still numerous, whether they be bringing the vectors into focus, the systems of expression of transgenes or the neutralization of immune responses of the host against the vector, the product of transgenes, or the knowledge of the considered pathologies of physiopathology. Solving these difficulties entails the gathering of multiple disciplines, from chemistry to medicine, passing through virology and immunology.
authors.affiliation: INSERM Unit 429, Hĵpital Necker-Enfants Malades, Paris, France. fischer@necker.fr
authors.forename: A
authors.initials: A
authors.lastname: Fischer
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends*; D005822:Genetic Vectors; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D012190:Retroviridae / Q000235:genetics; D019076:Transgenes