Radical scavengers from the entomogenous deuteromycete Beauveria amorpha.
The culture medium of Beauveria amorpha Hohn. exhibited strong radical scavenging properties. Activity-directed fractionation assisted by a radical scavenging assay on TLC afforded two active compounds which were identified as 6-methyl-2,4-dihydroxyphenyl 4-O-methyl-beta-D-glucopyranoside (1) and (-)-terredionol (2). Compound 1 displays radical scavenging and lipid peroxidation inhibitory activity comparable to those of TroloxC, ascorbic acid or quercetin.
Hu
Fenglin
F
Institute of Pharmacy, Friedrich-Schiller-University, Jena, Germany.
Schmidt
Karen
K
Stoyanova
Stefka
S
Zengzhi
Li
L
Gräfe
Udo
U
Hamburger
Matthias
M
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D002839:Chromans / Q000302:isolation & purification / Q000494:pharmacology; D003512:Cyclohexanones / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D003904:Mitosporic Fungi / Q000737:chemistry*; D009005:Monosaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016716:PC12 Cells; D011794:Quercetin / Q000494:pharmacology; D051381:Rats; D014810:Vitamin E / Q000031:analogs & derivatives
C452874:6-methyl-2,4-dihydroxyphenyl 4-O-methyl-glucopyranoside; D000975:Antioxidants; D002839:Chromans; D003512:Cyclohexanones; D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D009005:Monosaccharides; C452875:terredionol; D014810:Vitamin E; D011794:Quercetin; D001205:Ascorbic Acid; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid