Applications of display technologies to proteomic analyses.
With the rapid accumulation of genetic information, development of general experimental approach suitable for large scale annotation and profiling of the whole proteome have become one of the major challenges in postgenomic era. Biomolecular display technologies, which allow expressing of a large pool of modularly coded biomolecules, are extremely useful for accessing and analyzing protein diversity and interaction profile on a large scale. Recent advances in protein display technologies and their applications to proteomic analyses have been discussed.
Ma
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Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Li
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D003001:Cloning, Molecular; D020650:Combinatorial Chemistry Techniques; D005057:Eukaryotic Cells / Q000378:metabolism*; D005544:Forecasting; D019151:Peptide Library; D011387:Prokaryotic Cells / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D020543:Proteome / Q000032:analysis* / Q000378:metabolism
D019151:Peptide Library; D011506:Proteins; D020543:Proteome