[Combined five tumor markers in detecting primary hepatic carcinoma].
OBJECTIVE
To increase the detection rate of primary hepatic carcinoma (PHC) and to diagnose PHC earlier.


METHODS
AFP was combined with r-glutamyle transpeptidase (r-GT), alpha-fucosidase (AFU), tumor necrosis factor-alpha (TNF-alpha) and DR-70.


RESULTS
The positive detection rate of PHC negative AFP with combined four markers was 9.4%. The total positive detection rate of PHC with combined five tumor markers reached 98.0% which was significantly higher than that with AFP (P < 0.01).


CONCLUSIONS
The positive detection rate of PHC can be increased by combined five tumor markers. It is helpful in diagnosing PHC earlier and can differentiate PHC from liver cirrhosis.
Ma
J
J
Department of Clinical Laboratory, Qianfoshan Hospital of Shandong Province, Ji'nan 250014, China.
Gong
Q
Q
Lin
M
M
Xi
Y
Y
Wang
M
M
Chen
Z
Z
Pei
Z
Z
Ma
W
W
D014408:Biomarkers, Tumor / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis; D005644:alpha-L-Fucosidase / Q000032:analysis; D005723:gamma-Glutamyltransferase / Q000032:analysis
D014408:Biomarkers, Tumor; D014409:Tumor Necrosis Factor-alpha; D000509:alpha-Fetoproteins; D005723:gamma-Glutamyltransferase; D005644:alpha-L-Fucosidase