Long-term retention of injected barium-133 in man.
Data are presented on the whole-body retention of 133Ba (half-life 10.74 y), over periods of up to 13 y after injection into six healthy male volunteers aged 25-81, and on their levels of biochemical markers for bone turnover. The results are relevant to propositions underlying the ICRP's current (Publication 67) and former (Publication 20) models of alkaline earth metabolism. The tracer was predominantly skeletal within weeks of the injection, as predicted in the current model. The mean retention accorded satisfactorily throughout with predictions based on the current model, but this accord does not necessarily validate the model, for two reasons. First, parameter values attributed to barium were influenced by data emerging during the early years of this study. Second, bone resorption rates in these subjects, as indicated by urinary markers, appear insufficient to explain the long-term reductions in skeletal retention which, in the present model, arise exclusively through this mechanism.
Newton
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Biosciences, AEA Technology plc, Harwell, Oxon, UK. drd.newton@virgin.net
Ancill
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Naylor
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Eastell
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood / Q000652:urine; D000596:Amino Acids / Q000097:blood / Q000652:urine; D001465:Barium Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D003094:Collagen / Q000097:blood / Q000652:urine; D024042:Collagen Type I / Q000097:blood / Q000652:urine; D019583:Dose Fractionation, Radiation; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood / Q000652:urine; D010455:Peptides / Q000097:blood / Q000652:urine; D014018:Tissue Distribution
D000596:Amino Acids; D001465:Barium Radioisotopes; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; C036020:deoxypyridinoline; D003094:Collagen; D000469:Alkaline Phosphatase