title: [Beta-catenin and its mRNA in renal cell carcinoma].
abstract: OBJECTIVE
  To investigate the role of beta-catenin in renal cell carcinoma.
  
  
  METHODS
  The expression of beta-catenin in 26 cases of renal cell carcinoma was studied by LSAB immunohistochemistry, Western blotting and RT-PCR.
  
  
  RESULTS
  The expression of beta-catenin was higher in cancer tissues than in normal kidney tissues in 25 cases and the level of beta-catenin was associated with tumor stage. The expression was obviously higher in pT3 and pT4 than in pT1 and pT2 (P < 0.01). The expression of its mRNA was not higher in tumor cells than in normal cells. Beta-catenin was expressed mainly in cytoplasm.
  
  
  CONCLUSIONS
  Beta-catenin might be related to the occurrence and development of kidney tumor.
authors.affiliation: Institute of Urology, Beijing Medcal University, Beijing 100034, China.
authors.forename: T
authors.initials: T
authors.lastname: Zang
authors.forename: L
authors.initials: L
authors.lastname: Zhuang
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Xin
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D051176:beta Catenin
chemical_list: D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D012333:RNA, Messenger; D015534:Trans-Activators; D051176:beta Catenin