From funny current to HCN channels: 20 years of excitation.
The "funny" (pacemaker) current has unusual characteristics, including activation on hyperpolarization, permeability to K(+) and Na(+), modulation by internal cAMP, and a tiny, single-channel conductance. In cardiac cells and neurons, pacemaker channels control repetitive activity and excitability. The recent cloning of HCN subunits provides new insight into the molecular basis for the funny channel properties.
Accili
E A
EA
. School of Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Proenza
C
C
Baruscotti
M
M
DiFrancesco
D
D
D000818:Animals; D054815:Cyclic Nucleotide-Gated Cation Channels; D004594:Electrophysiology; D006801:Humans; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000737:chemistry / Q000502:physiology*; D007700:Kinetics; D009419:Nerve Tissue Proteins; D009712:Nucleotides, Cyclic / Q000502:physiology; D015221:Potassium Channels; D011499:Protein Processing, Post-Translational
D054815:Cyclic Nucleotide-Gated Cation Channels; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels; D009419:Nerve Tissue Proteins; D009712:Nucleotides, Cyclic; D015221:Potassium Channels