Experimental evidence for a non-renin mediated pathway during TAME-esterase induced contractions in rat aorta in vitro.
Possible pharmacological effects of N-alpha-tosyl L-arginine methyl ester [TAME] were studied on rat aorta strips in vitro. Results showed that [TAME]-esterase was an endothelium dependent component that involved a nitric oxide cyclic-GMP mediated pathway. Furthermore, during activation of Kinin-Kallikrein system, TAME-esterase induced contractions involve degradation of kinins by kininases.
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Department of Health and Medical Sciences, Faculty of Science, University of Mauritius, Reduit.
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D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001120:Arginine / Q000494:pharmacology; D002216:Captopril / Q000494:pharmacology; D006152:Cyclic GMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D008751:Methylene Blue / Q000494:pharmacology; D009119:Muscle Contraction / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D010447:Peptide Hydrolases / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012083:Renin; D015398:Signal Transduction / Q000502:physiology*; D014106:Tosylarginine Methyl Ester / Q000494:pharmacology; D014661:Vasoconstriction
D000806:Angiotensin-Converting Enzyme Inhibitors; D014106:Tosylarginine Methyl Ester; D001120:Arginine; D002216:Captopril; D010447:Peptide Hydrolases; C023073:tosylarginine methyl ester hydrolase; D012083:Renin; D006152:Cyclic GMP; D008751:Methylene Blue