Angiotensin 1-7 increases quantal content and facilitation at the frog neuromuscular junction.
At the neuromuscular junction, several endogenous substances have been shown to act presynaptically to modify transmitter release. Here we show that angiotensin 1-7, a vasoactive peptide of the renin-angiotensin system, increased quantal content in a dose-dependent manner, with a maximal increase of 78% at 250 nM. At the same dose, angiotensin 1-7 increased paired pulse facilitation by 70%. This is the first report of angiotensin 1-7 altering a cholinergic synapse.
Bevilaqua
Enéias Ricardo
ER
Departamento de Fisiologia e Biofísica, ICB-Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
Kushmerick
Christopher
C
Beirão
Paulo Sérgio Lacerda
PS
Naves
Lígia Araujo
LA
D000109:Acetylcholine / Q000378:metabolism; D000803:Angiotensin I / Q000494:pharmacology* / Q000502:physiology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D018482:Muscle, Skeletal / Q000294:innervation; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology* / Q000502:physiology; D011892:Rana catesbeiana
D000959:Antihypertensive Agents; D010446:Peptide Fragments; D000803:Angiotensin I; C118790:angiotensin I (1-7); D000109:Acetylcholine