Transposition of the great arteries and hypocalcemia in a patient with fetal hydantoin syndrome.
We report a patient with fetal hydantoin syndrome (FHS) with associated d-transposition of the great arteries (d-TGA) and persistent hypocalcemia. d-TGA and hypocalcemia have each been individually reported once in association with FHS, but these patients were also prenatally exposed to phenobarbital. To our knowledge, this is the first report of these problems occurring after prenatal exposure to hydantoin alone. The combination of congenital heart disease and hypocalcemia in our patient raises the possibility of a hydantoin effect on neural crest migration.
Shah
Mrugeshkumar K
MK
Department of Human Genetics and Pediatrics, Division of Neonatology, Tulane University School of Medicine, New Orleans, LA, USA.
Morava
Eva
E
Gill
William
W
Marble
Michael R
MR
D000014:Abnormalities, Drug-Induced; D000328:Adult; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D006827:Hydantoins / Q000009:adverse effects*; D006996:Hypocalcemia / Q000139:chemically induced*; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013577:Syndrome; D014188:Transposition of Great Vessels / Q000139:chemically induced*
D006827:Hydantoins