An efficient route to alkyl chlorides from alcohols using the complex TCT/DMF.
[reaction: see text] Efficient conversion of alcohols and beta-amino alcohols to the corresponding chlorides (and bromides) can be carried out at room temperature in methylene chloride, using 2,4,6-trichloro[1,3,5]triazine and N,N-dimethyl formamide. This procedure can also be applied to optically active carbinols.
De Luca
Lidia
L
Dipartimento di Chimica, Università degli Studi di Sassari, Via Vienna 2, I-07100 Sassari, Italy.
Giacomelli
Giampaolo
G
Porcheddu
Andrea
A