[Effects of inflammatory infiltration on the formation of abdominal aortic aneurysm].
OBJECTIVE
To explore inflammatory infiltration and its effects on the formation of abdominal aortic aneurysm (AAA).


METHODS
Immunohistochemical technique was used to detect lymphocyte (CD45 positive) and macrophage (CD68 positive) infiltration while in situ hybridization was applied to investigate the mRNA expression of Matrix Metalloproteinase-9 (MMP-9) in 20 cases of human AAA and 4 cases of normal human abdominal aortas.


RESULTS
Inflammatory infiltration occurred in every case of AAA with various degree, and there was a parallel tendency between the degree of injury of abdominal aortic elastin and that of inflammatory infiltration in AAA. Inflammatory infiltration was not found in normal aortas. MMP-9 mRNA was detected in macrophages and lymphocytes in all 20 cases, in smooth muscle cells in 13, and not in normal abdominal aortas.


CONCLUSIONS
Inflammatory infiltration attended and enhanced the formation of AAA through a complex of sequence of biochemical, cellular and immune events.
Zhang
J
J
3rd Department of General Surgery, First Clinical College, China Medical University, Shenyang 110001.
Wang
X
X
Wang
B
B
Xin
S
S
Zhang
Q
Q
Duan
Z
Z
D017544:Aortic Aneurysm, Abdominal / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008214:Lymphocytes / Q000502:physiology*; D008264:Macrophages / Q000502:physiology*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis / Q000235:genetics; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics
D012333:RNA, Messenger; D020780:Matrix Metalloproteinase 9