title: Vascular response of current and potential dental etchants.
abstract: This study investigated the hemostatic properties of current and potential dentin conditioners by observing the contraction of blood vessels using the rat carotid artery model. Four different agents (3M Scotchbond etchant, NRC, RC-Prep, File-Eze) were used. Dose-dependent contractions/relaxations of the test materials were first compared with epinephrine, followed by administration of papaverine, which was used to reverse epinephrine-induced contractions. In all sequences, the contraction or relaxation forces produced by the test and control materials were recorded using a force displacement transducer. RC-Prep was the only agent to produce epinephrine-like contractions (vasoconstriction) in the rat carotid artery. No contraction could be achieved with 3M etchant. Dose-dependent relaxations were observed with 3M etchant, which eventually led to collapse of the vessel wall; afterward, no response could be achieved with administration of adrenalin. File-Eze and NRC also did not cause vasoconstriction. Both materials caused dose-dependent relaxations in the smooth muscle. However, subsequent administration of adrenalin and papaverine caused dose-dependent contractions and relaxations, respectively, showing that these etchant effects did not lead to collapse of the vessel wall, as did 3M etchant.
authors.affiliation: Department of Pedodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.
authors.forename: Zafer C
authors.initials: ZC
authors.lastname: Cehreli
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Onur
authors.forename: Fügen
authors.initials: F
authors.lastname: Taşman
authors.forename: Ayşe
authors.initials: A
authors.lastname: Gümrükçuölu
mesh_terms: D000134:Acid Etching, Dental; D000704:Analysis of Variance; D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects*; D002614:Chelating Agents / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D005260:Female; D006490:Hemostatics / Q000494:pharmacology*; D008298:Maleates / Q000494:pharmacology; D008422:Materials Testing; D009930:Organic Chemicals; D063065:Organophosphonates; D010545:Peroxides / Q000494:pharmacology; D010756:Phosphoric Acids / Q000494:pharmacology; D051381:Rats; D018709:Statistics, Nonparametric; D014508:Urea / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014885:Waxes / Q000494:pharmacology
chemical_list: D002614:Chelating Agents; C454541:File-Eze; D006490:Hemostatics; D008298:Maleates; D009930:Organic Chemicals; D063065:Organophosphonates; D010545:Peroxides; D010756:Phosphoric Acids; C454540:Scotchbond etchant; D014662:Vasoconstrictor Agents; D014885:Waxes; C444699:non-rinse conditioner; C025081:RC-Prep; D014508:Urea; D004492:Edetic Acid