A BAC contig of approximately 400 kb contains the classical class I major histocompatibility complex (MHC) genes of cattle.
A cattle BAC library derived from an MHC homozygous animal was screened for MHC class I genes. This revealed at least nine class I-related genes in a contig spanning approximately 400 kb, and several additional genes on other clones. The three classical class I genes expressed on this haplotype (A14) were shown to be distributed over a region at most 212 kb apart.
Di Palma
F
F
NIDCD, National Institutes of Health, Rockville, MD 20850-3227, USA.
Archibald
S D
SD
Young
J R
JR
Ellis
S A
SA
D000818:Animals; D002417:Cattle / Q000235:genetics*; D022202:Chromosomes, Artificial, Bacterial; D020451:Contig Mapping; D015395:Histocompatibility Antigens Class I / Q000235:genetics*
D015395:Histocompatibility Antigens Class I