Antiallergic/antiasthmatic effect of novel antiallergic hexapeptide-95/220 in various experimental models.
The effects of newly synthesized antiallergic hexapeptide 95/220 was investigated on various allergic and asthmatic test models. This newly developed peptide was found to be more potent than clinically used drug disodium cromoglycate (DSCG). Hexapeptide 95/220 inhibited immediate hypersensitivity reactions such as passive cutaneous anaphylaxis (PCA) and mast cell degranulation in rats, antigen-induced bronchoconstriction in actively sensitized guinea pigs in dose dependent manner like DSCG. Antigen-induced contraction of guinea pig ileum was also markedly inhibited by this newly developed hexapeptide in the same fashion as ketotifen and DSCG did but at comparatively lower dose. Egg albumin-induced histamine release was also blocked by this hexapeptide from chopped lung tissues of sensitized guinea pigs. These results suggest that hexapeptide' 95/220 has potent inhibitory effect on immediate hypersensitivity reactions thereby inhibiting mediator release from mast cell. Moreover, this newly synthesized peptide is orally active and effective at lower doses as compared to standard drugs.
Singh
R
R
Division of Pharmacology, Central Drug Research Institute, Lucknow, India.
Nath
A
A
Gupta
P P
PP
Shukla
M
M
Khare
S K
SK
Kundu
B
B
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D016084:Bronchoconstriction / Q000187:drug effects*; D017332:Cetirizine / Q000494:pharmacology; D004205:Cromolyn Sodium / Q000494:pharmacology; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D006969:Hypersensitivity, Immediate / Q000517:prevention & control*; D007665:Ketotifen / Q000494:pharmacology; D008168:Lung / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018926:Anti-Allergic Agents; D018927:Anti-Asthmatic Agents; D009842:Oligopeptides; C450048:hexapeptide-95; D004205:Cromolyn Sodium; D007665:Ketotifen; D017332:Cetirizine