title: [Comparative study of HLA-DQA1 and HLA-DRB1 allele in patients with endometriosis and adenomyosis].
abstract: OBJECTIVE
  To make a comparative study of HLA-DQA1 and HLA-DRB1 allele frequencies in the cases of endometriosis and adeonmyosis.
  
  
  METHODS
  The allelic types of HLA-DQA1 and HLA-DRB1 were detected by polymerase chain reaction-sequence specific primers (PCR-SSP) technique in 51 cases of endometriosis, 45 cases of adenomyosis, and 44 normal individuals as the control.
  
  
  RESULTS
  The frequencies of HLA-DQA1*0401(7.8%, 10.0%) were significantly increased in the endometriosis group and the adenomyosis group (Pc=0.03, Pc=0.01), and the frequencies of HLA-DQA1*0301(8.8%, 5.6%) were significantly decreased in these two groups (Pc=0.00, Pc=0.00).There was no significant difference between the frequencies of HLA-DQA1 and HLA-DRB1 of endometriosis and adenomyosis.
  
  
  CONCLUSIONS
  The results indicate that HLA-DQA1*0301 and *0401 alleles are associated with both endometriosis and adenomyosis, and there is perhaps common mechanism involved in both endometriosis and adenomyosis based on HLA-DQA1 and HLA-DRB1 allele frequencies.
authors.affiliation: Department of Gynecology and Obstetrics, Zhujiang Hospital, First Military Medical University, Guangzhou, Guangdong, 510282 P. R. China. Houwm@gdvnet.com
authors.forename: Lili
authors.initials: L
authors.lastname: Zong
authors.forename: Dejing
authors.initials: D
authors.lastname: Pan
authors.forename: Weiming
authors.initials: W
authors.lastname: Chen
authors.forename: Yuanli
authors.initials: Y
authors.lastname: He
authors.forename: Zehuan
authors.initials: Z
authors.lastname: Liu
authors.forename: Jianghai
authors.initials: J
authors.lastname: Lin
authors.forename: Anlong
authors.initials: A
authors.lastname: Xu
mesh_terms: D044466:Asian People / Q000235:genetics; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains