[Relationship between GSTM1 genotype and susceptibility to senile cataract].
OBJECTIVE
To study the relationship between the glutathione s-transferase gene deletion and cataract formation.


METHODS
Blood cells of total of 77 cases with senile cataract and 76 controls were detected for GSTM1 gene, and the subcapsular epithelial cells of 22 cataract lenses were also detected for GSTM1 gene.


RESULTS
The GSTM1 gene deletion rate in cataract group was 53.25% and that in the control group was 46.05%, they being not significantly different statistically (chi(2) = 0.750, P > 0.05, OR = 0.75). GSTM1 gene deletion rate in the subcapsular epithelial cells of 20 cases was basically consistent with that in blood cells.


CONCLUSIONS
GSTM1 gene deletion is not related to senile cataract formation.
Hao
Y
Y
Department of Ophthalmology, General Hospital of the PLA, Beijing 100853.
He
S
S
Gu
Z
Z
Zhao
Y
Y
Li
X
X
Wang
C
C
Li
Q
Q
Liu
T
T
D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005982:Glutathione Transferase