title: Comparison of cyclizine and ondansetron for the prevention of postoperative nausea and vomiting in laparoscopic day-case gynaecological surgery.
abstract: Seventy-four patients undergoing laparoscopic gynaecological surgery were randomly allocated to two groups receiving cyclizine 50 mg or ondansetron 4 mg at induction of anaesthesia. Anaesthetic and postoperative analgesia regimens were standardised. Approximately half of the patients in each group experienced some degree of postoperative nausea and vomiting (cyclizine, 56%; ondansetron, 54%). There was no difference between groups in respect of pre- and postdischarge incidence. Mean (SD) time to eye opening was significantly prolonged in the cyclizine group [10 (4) min vs. 8 (2) min; p < 0.001], but this had no influence on discharge times. Cyclizine and ondansetron appear equally effective in preventing postoperative nausea and vomiting but the 10-fold price differential favours cyclizine.
authors.affiliation: Anaesthetics, Ninewells Hospital, Dundee DD1 9SY, UK.
authors.forename: K
authors.initials: K
authors.lastname: Grimsehl
authors.forename: J B
authors.initials: JB
authors.lastname: Whiteside
authors.forename: N
authors.initials: N
authors.lastname: Mackenzie
mesh_terms: D000328:Adult; D000556:Ambulatory Surgical Procedures; D000762:Anesthesia Recovery Period; D000932:Antiemetics / Q000627:therapeutic use*; D003501:Cyclizine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D010535:Laparoscopy; D017294:Ondansetron / Q000627:therapeutic use*; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D012702:Serotonin Antagonists / Q000627:therapeutic use
chemical_list: D000932:Antiemetics; D006634:Histamine H1 Antagonists; D012702:Serotonin Antagonists; D017294:Ondansetron; D003501:Cyclizine