Vascular-platelet and plasma hemostasis regulators from bloodsucking animals.
Saliva of bloodsuckers (leeches, insects, ticks, vampire bats) contains various regulators of some hemostatic stages. This review summarizes information on their structural characteristics and mechanisms of action. Most bloodsuckers are shown to inhibit vascular-platelet hemostasis by blocking collagen-induced platelet adhesion/aggregation. Plasma hemostasis is inhibited by blocking activation of factor X or factor Xa directly.
Basanova
A V
AV
School of Biology, Lomonosov Moscow State University, Moscow, 119899, Russia. leech@humgen.siobc.ras.ru
Baskova
I P
IP
Zavalova
L L
LL
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D002448:Cell Adhesion; D002685:Chiroptera; D003094:Collagen / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects*; D005170:Factor X / Q000378:metabolism; D015951:Factor Xa / Q000378:metabolism; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D007313:Insecta; D007865:Leeches; D010974:Platelet Aggregation; D013925:Thromboplastin / Q000378:metabolism; D013987:Ticks
D005170:Factor X; D003094:Collagen; D013925:Thromboplastin; D015951:Factor Xa