[Expression and significance of Fas/APO-1 and bcl-2 protein in renal cell carcinoma].
OBJECTIVE
To investigate the role of Fas/APO-1 and bcl-2 in occurrence and progression of renal cell carcinoma.


METHODS
Immunohistochemistry method was used to detect the expression of Fas/APO-1 and bcl-2 protein in 35 cases of renal cell carcinoma tissues and 26 cases of normal renal tissues.


RESULTS
The expression rate of Fas/APO-1 protein in renal cell carcinoma tissues was 57.14%, significantly lower than that in normal renal tissues (84.62%) (P < 0.05), and the intensity of expression was also lower. The expression rate of bcl-2 protein reached 80.00%, much higher than that in normal renal tissues (53.85%) (P < 0.05).


CONCLUSIONS
Both Fas/APO-1 and bcl-2 take part in the occurrence and progression of renal cell carcinoma.
Li
H
H
Institute of Urology, First Teaching Hospital, Beijing Medical University, Beijing 100034.
Yu
L
L
Yang
B
B
Kong
X
X
Mi
P
P
Guo
Y
Y
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D019014:fas Receptor / Q000096:biosynthesis*
D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor