title: The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats.
abstract: The effects of a previous long-term administration of the mitochondrial toxin 3-nitropropionic acid were studied on an animal model of tardive dyskinesia, i.e., the frequency of spontaneous tongue protrusions in rats repeatedly treated with reserpine. 3-Nitropropionic acid (10 or 15 mg/kg i.p., every other day for 17 days) potentiated the increase in tongue-protrusion frequency induced by reserpine (1 mg/kg, s.c., every other day for 3 days) but did not modify reserpine-induced increase in immobility duration and decrease in locomotion frequency. These results support the notion that neurotoxic events are associated with the development of tardive dyskinesia.
authors.affiliation: Departamento de Farmacologia, São Paulo, SP, Brazil.
authors.forename: Patricia R V
authors.initials: PR
authors.lastname: Calvente
authors.forename: Carlos C S
authors.initials: CC
authors.lastname: Araujo
authors.forename: Marcelo
authors.initials: M
authors.lastname: Bergamo
authors.forename: Vanessa C
authors.initials: VC
authors.lastname: Abilio
authors.forename: Vânia
authors.initials: V
authors.lastname: D'Almeida
authors.forename: Rosana De A
authors.initials: Rde A
authors.lastname: Ribeiro
authors.forename: Filho Roberto
authors.initials: FR
authors.lastname: Frussa
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000633:toxicity; D000818:Animals; D003292:Convulsants / Q000633:toxicity; D004195:Disease Models, Animal; D004357:Drug Synergism; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D009574:Nitro Compounds; D011422:Propionates / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000633:toxicity*
chemical_list: D018759:Adrenergic Uptake Inhibitors; D003292:Convulsants; D009574:Nitro Compounds; D011422:Propionates; D012110:Reserpine; C015392:3-nitropropionic acid