[Cytokine regulation of liver inflammation and fibrosis during chronic hepatic diseases].
Serum concentrations of antiinflammatory cytokines and growth factors were measured in 30 patients with chronic viral hepatitis (HCV), mainly HCV RNA, and 10 patients with liver cirrhosis (LC), classes B and C according to Child-Pew. Serum concentrations of tumor necrosis factor-alpha (TNF alpha), granulocytic-macrophagal colony-stimulating factor (GM-CSF), and growth-transforming factor-1 beta (TGF1 beta) were increased in 63.86 and 80% patients with HCV and LC, respectively, and differed significantly (p < 0.05) from the control. The level of TNF alpha positively correlated with the concentration of alanine aminotransferase (r = 0.14). A positive correlation between TGF1 beta and histologic activity index was detected (r = 0.16). Increased levels (p < 0.05) of IL-5, TNF alpha, and TGF1 beta were detected in LC patients in comparison with the control. Patients with LC concomitant with anemia had higher (though not significantly) concentrations of TNF alpha in comparison with patients without anemia. Increased levels of proinflammatory cytokines and growth factors in the sera of patients with HCV and LC indicate activation of immunocompetent cells, including mononuclear phagocytes. These data are in line with experimental findings, indicating an important role of the studied cytokines in the development of hepatic inflammation, fibrosis, and cytopenic syndromes.
Mammaev
S N
SN
Lukina
E A
EA
Shul'pekova
Iu O
IuO
Levina
A A
AA
Ivashkin
V T
VT
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000276:immunology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D016207:Cytokines