[Intrauterine growth retardation and cerebral palsy].
OBJECTIVE
To obtain the prevalence of cerebral palsy in children affected with intrauterine growth retardation (IUGR) and to explore the association between IUGR and cerebral palsy.


METHODS
A cross-sectional survey was carried out among children aged under 7 years in seven cities of south Jiangsu Province.


RESULTS
There were 5.6% (95% CI 5.6% to 5.7%) of the children classified as IUGR with a bimodal distribution, the highest in the 35-36 and 42-43 weeks of gestational age. The prevalence of cerebral palsy (CP) in IUGR children was 5.7@1000 (95% CI of 4.7@1000 to 6.9@1000), 4.2 times more than that in non-IUGR children (95% CI of 3.4-5.2). The prevalence of CP in IUGR children of preterm and term delivery (< 37 weeks and > or = 37 weeks of gestational age) was 1.9 (95% CI of 1.2 to 3.0) and 4.2 (95% CI of 3.3 to 5.3) times more than that in non-IUGR children, respectively. Multiple logistic regression analysis showed the effect of IUGR on CP for children with birth weight greater than 2,500 g, after controlling for birth weight and gestational age. CP prevalence in IUGR children was two times more than that in non-IUGR children. Furthermore, prevalence of IUGR in children with birth weight lower than the 3rd percentile and in those with the 3rd percentile to lower than the 10th percentile was 3.4 and 1.8 times more than that in non-IUGR children, respectively.


CONCLUSIONS
The prevalence of cerebral palsy in IUGR children was 5.7@1000, 4.2 times that in non-IUGR children and IUGR is an independent risk factor for cerebral palsy.
Liu
J
J
Institute for Reproductive and Child Health, Peking University Health Science Center, Beijing 100083, China.
Li
Z
Z
Lin
Q
Q
D001724:Birth Weight; D002547:Cerebral Palsy / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000150:complications*; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D011247:Pregnancy