title: Successful treatment of a case with rapidly progressive Bronchiolitis obliterans organizing pneumonia (BOOP) using cyclosporin A and corticosteroid.
abstract: A 60-year-old woman was suffering from acute onset and progressive respiratory distress. Her radiographic findings showed bilateral volume loss in her lower lobes and consolidation predominantly distributed in peribronchovascular areas. The biopsied specimens performed by video-assisted thoracoscopic surgery revealed prominent fibromyxoid connective tissue within the terminal respiratory bronchioles and the alveolar spaces along the airways without marked interstitial fibrosis. No relevant cause was determined, and she was diagnosed as having idiopathic BOOP. Although her clinical course was fulminant with a poor reaction to steroid therapy, simultaneous administration of cyclosporin A and corticosteroid elicited a rapid improvement. This case report presents the effectiveness of cyclosporin A in the treatment of progressive BOOP.
authors.affiliation: Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai.
authors.forename: Daizo
authors.initials: D
authors.lastname: Koinuma
authors.forename: Makoto
authors.initials: M
authors.lastname: Miki
authors.forename: Masahito
authors.initials: M
authors.lastname: Ebina
authors.forename: Minoru
authors.initials: M
authors.lastname: Tahara
authors.forename: Koichi
authors.initials: K
authors.lastname: Hagiwara
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Taguchi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nukiwa
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D018549:Cryptogenic Organizing Pneumonia / Q000188:drug therapy*; D016572:Cyclosporine / Q000627:therapeutic use*; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D016572:Cyclosporine; D011239:Prednisolone