title: Partitioning of polychlorinated biphenyls and hexachlorobenzene into human faeces.
abstract: The dietary absorption of persistent lipophilic organic pollutants (PLOPs) in humans is believed to occur via partitioning of the chemical between the lumen and the wall of the digestive tract. As such, the partitioning properties of the lumen contents are a key factor governing absorption. In this study, the partitioning properties of faeces were measured for 11 polychlorinated biphenyls and hexachlorobenzene (HCB). Four volunteers participated in the study, each of them providing faeces from a normal diet and a vegetarian diet. The faeces/gas equilibrium partition coefficient K(FG) varied by over three orders of magnitude between the different compounds. A linear relationship between log K(FG) and log KOA, the octanol/air partition coefficient, was observed. The slope of the relationship was > 1, indicating that the solvent properties of faeces were less polar than those of octanol. For a given compound, KFG varied up to a factor of 2.8 between the individuals on a normal diet. The influence of the vegetarian diet on K(FG) was negligible for the two volunteers who simply deleted fish and animal products from their normal diet, but K(FG) increased on average by a factor of 2 in the two individuals who increased their consumption of less readily digestible whole grains and vegetables in their vegetarian diet. On the basis of K(FG), the fugacities in the faeces were calculated. They were found to be much lower than the fugacities in blood. It is hypothesised that this is due to a temporary decrease in the fugacity in the wall of the jejunum caused by absorption of dietary lipids that results in equilibration between the lumen contents and the wall of the digestive tract at a fugacity below that present in the blood and the rest of the body.
authors.affiliation: Ecological Chemistry and Geochemistry, University of Bayreuth, Germany.
authors.forename: G Andreas
authors.initials: GA
authors.lastname: Moser
authors.forename: Michael S
authors.initials: MS
authors.lastname: McLachlan
mesh_terms: D000328:Adult; D004032:Diet; D005243:Feces; D006581:Hexachlorobenzene / Q000032:analysis / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000493:pharmacokinetics*
chemical_list: D006581:Hexachlorobenzene; D011078:Polychlorinated Biphenyls