title: An unusual metastatic motilin-secreting neuroendocrine tumour with a 20-year survival. Pathological, biochemical and motility features.
abstract: Motilin-secreting neuroendocrine tumours have been rarely described. Immunohistochemical, biochemical and motility investigations were performed in a 62-year-old man with liver and bone metastases of a motilin-secreting neuroendocrine tumour originating from a rectal polyp removed 14 years previously. Symptoms related to liver metastases were reduced by a right hepatectomy whereas plasma motilin levels were decreased. The patient also underwent two operations for spinal cord decompression and survived 6 more years under medical treatment, mainly octreotide. Immunohistochemistry revealed predominant expression of motilin-containing cells, with rare cells expressing somatostatin and pancreatic polypeptide, and staining for only one panendocrine marker, neurone-specific enolase. A liver tumour extract contained 17.9 microg motilin per gram of tissue, which permitted to isolate and characterize human motilin, which was identical to porcine motilin. Plasma column gel chromatography revealed a main peak corresponding apparently to porcine motilin. The patient had no symptoms of disturbed motility. Gastric emptying and gastroduodenojejunal motility were found within normal limits. The absence of alterations of gut motility was perhaps related to sustained autonomous motilin production. The long evolution of this type of tumour suggests that plasma motilin determination should be added to the investigations for neuroendocrine tumours.
authors.affiliation: Department of Gastroenterology, University Hospital St-Luc, Brussels, Belgium. rene.fiasse@gaen.ucl.ac.be
authors.forename: R
authors.initials: R
authors.lastname: Fiasse
authors.forename: P
authors.initials: P
authors.lastname: Deprez
authors.forename: B
authors.initials: B
authors.lastname: Weynand
authors.forename: P
authors.initials: P
authors.lastname: De Clercq
authors.forename: E
authors.initials: E
authors.lastname: Wibin
authors.forename: S
authors.initials: S
authors.lastname: Pauwels
authors.forename: J
authors.initials: J
authors.lastname: Rahier
authors.forename: T
authors.initials: T
authors.lastname: Peeters
mesh_terms: D001859:Bone Neoplasms / Q000097:blood* / Q000556:secondary; D018572:Disease-Free Survival; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000378:metabolism*; D018358:Neuroendocrine Tumors / Q000097:blood* / Q000556:secondary; D012004:Rectal Neoplasms / Q000097:blood* / Q000473:pathology*; D013997:Time Factors
chemical_list: D009037:Motilin