title: The nature of chromosomal aberrations detected in humans exposed to benzene.
abstract: Benzene is an established cause of human leukemia that is thought to act by producing chromosomal aberrations and altered in cell differentiation. In several recent studies increased levels of chromosomal aberrations in peripheral blood lymphocytes were correlated with a heightened risk of cancer, especially hematological malignancies. Thus, chromosomal aberrations may be a predictor of future leukemia risk. Previous studies exploring whether benzene exposure induces chromosomal aberrations have yielded mostly positive results. However, it remains unclear whether the chromosomal aberrations induced by benzene occur in a distinct pattern. Here, we thoroughly review the major chromosome studies published to date in benzene-exposed workers, benzene-poisoned and preleukemia patients, and leukemia cases associated with benzene expose. Although three cytogenetic markers (chromosomal aberrations, sister chromatid exchanges, and micronuclei) are commonly examined, our primary focus is on studies of chromosomal aberrations, because only this marker has so far been correlated with increased cancer risk. This review surveys the published literature, analyzes the study results, and discusses the characteristics of effects reported. In most studies of currently exposed workers, increases in chromosomal aberrations were observed. However, due to the relatively small number of affected individuals and variability in the reported aberrations, firm conclusions cannot be made about the involvement of specific chromosomes or chromosome regions. Further, in leukemia cases associated with benzene exposure, there is no evidence of a unique pattern of benzene-induced chromosomal aberrations in humans. Leukemia cases associated with benzene exposure are, however, more likely to contain clonal chromosome aberrations then those arising de novo in the general population.
authors.affiliation: School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley 94720-7360, USA. luoping@uclink.berkeley.edu
authors.forename: Luoping
authors.initials: L
authors.lastname: Zhang
authors.forename: David A
authors.initials: DA
authors.lastname: Eastmond
authors.forename: Martyn T
authors.initials: MT
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001554:Benzene / Q000009:adverse effects*; D015415:Biomarkers; D002273:Carcinogens / Q000633:toxicity*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007938:Leukemia / Q000139:chemically induced* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002273:Carcinogens; D001554:Benzene