title: Immunity to hepatitis C virus: stunned but not defeated.
abstract: Hepatitis C virus (HCV) readily causes a persistent infection, although some individuals spontaneously control infection. 'Successful' immune responses appear to be multi-specific and sustained-including a major role for CD4(+)T cells. Some antiviral CD8(+)T cells show reduced capacity to secrete antiviral cytokines either temporarily ('stunning') or in the long term ('stunting'). The co-ordination of multiple immune effector functions may be required to gain control of HCV.
authors.affiliation: Nuffield Department of Medicine, University of Oxford, Peter Medawar Building, South Parks Road, Oxford OX1 3SY, UK. klener@molbiol.ox.ac.uk
authors.forename: Paul
authors.initials: P
authors.lastname: Klenerman
authors.forename: Michaela
authors.initials: M
authors.lastname: Lucas
authors.forename: Ellie
authors.initials: E
authors.lastname: Barnes
authors.forename: Gillian
authors.initials: G
authors.lastname: Harcourt
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology* / Q000821:virology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism*
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta