title: [Linkage analysis of X-linked nuclear protein gene in Smith-Fineman-Myers syndrome].
abstract: OBJECTIVE
  To determine the linkage between Smith-Fineman-Myers syndrome (SFMS) and X-linked nuclear protein(XNP) locus.
  
  
  METHODS
  Polymerase chain reaction and denaturing polyacrylamide gel electrophoresis were used to genotype two polymorphic short tandem repeats within XNP gene.
  
  
  RESULTS
  One of the two short tandem repeats was informative in SFMS family from Shandong, China. Recombination between SFMS locus and XNP gene was observed in the SFMS family.
  
  
  CONCLUSIONS
  XNP gene is not associated with the disease in the SFMS family from Shandong, China. SFMS exhibits locus heterogeneity at molecular level.
authors.affiliation: Department of Medical Genetics, School of Medicine, Shandong University, Jinan, Shandong, 250012 P. R. China. gongyaoqin@yahoo.com
authors.forename: Qiji
authors.initials: Q
authors.lastname: Liu
authors.forename: Yaoqin
authors.initials: Y
authors.lastname: Gong
authors.forename: Bingxi
authors.initials: B
authors.lastname: Chen
authors.forename: Chenhong
authors.initials: C
authors.lastname: Guo
authors.forename: Jiangxia
authors.initials: J
authors.lastname: Li
authors.forename: Yishou
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D019465:Craniofacial Abnormalities / Q000235:genetics; D004265:DNA Helicases; D005260:Female; D008040:Genetic Linkage; D006130:Growth Disorders / Q000235:genetics; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D008297:Male; D009123:Muscle Hypotonia / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D013577:Syndrome; D014960:X Chromosome; D000075924:X-linked Nuclear Protein
chemical_list: D009687:Nuclear Proteins; D004265:DNA Helicases; C092332:ATRX protein, human; D000075924:X-linked Nuclear Protein