title: Five new nortropane alkaloids and six new amino acids from the fruit of Morus alba LINNE growing in Turkey.
abstract: Investigation of the constituents of the fruits of Morus alba LINNE (Moraceae) afforded five new nortropane alkaloids (1-5) along with nor-psi-tropine (6) and six new amino acids, morusimic acids A-F (7-12). The structures of the new compounds were determined to be 2alpha,3beta-dihydroxynortropane (1), 2beta,3beta-dihydroxynortropane (2), 2alpha,3beta,6exo-trihydroxynortropane (3), 2alpha,3beta,4alpha-rihydroxynortropane (4), 3beta,6exo-dihydroxynortropane (5), (3R)-3-hydroxy-12-[(1S,4S)-4-[(1S)-1-hydroxyethyl]-pyrrolidin-1-yll-dodecanoic acid-3-O-beta-D-glucopyranoside (7), (3R)-3-hydroxy-12-[(1S,4S)-4-[(1S)-1-hydroxyethyl]-pyrrolidin-1-yll-dodecanoic acid (8), (3R)-3-hydroxy-12-1(1R,4R,5S)-4-hydroxy-5-methyl-piperidin-1-yll-dodecanoic acid-3-O-beta-D-glucopyranoside (9), (3R)-3-hydroxy-12-[(1R,4R,5S)-4-hydroxy-5-methyl-piperidin-1-yll-dodecanoic acid (10), (3R)-3-hydroxy-12-[(1R,4R,5S)-4-hydroxy-5-hydroxymethyl-piperidin-1-yl]-dodecanoic acid-3-O-beta-D-glucopyranoside (11), and (3R)-3-hydroxy-12-[(1R,4S,5S)-4-hydroxy-5-methyl-piperidin-1-yl]-dodecanoic acid (12) on the basis of spectral and chemical data.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan. kusano@gly.oups.ac.jp
authors.forename: Genjirou
authors.initials: G
authors.lastname: Kusano
authors.forename: Shiho
authors.initials: S
authors.lastname: Orihara
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tsukamoto
authors.forename: Makio
authors.initials: M
authors.lastname: Shibano
authors.forename: Maksut
authors.initials: M
authors.lastname: Coskun
authors.forename: Aysegul
authors.initials: A
authors.lastname: Guvenc
authors.forename: Ceyda Sibel
authors.initials: CS
authors.lastname: Erdurak
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000596:Amino Acids / Q000737:chemistry / Q000302:isolation & purification*; D005638:Fruit; D009682:Magnetic Resonance Spectroscopy; D029586:Moraceae / Q000737:chemistry*; D014421:Turkey
chemical_list: D000470:Alkaloids; D000596:Amino Acids