[Hepatitis B virus replication status and its response to surgery for tumor in hepatocellular carcinoma patients with positive markers of HBV].
OBJECTIVE
To investigate the status of hepatitis B virus (HBV) activity in patients with hepatocellular carcinoma (HCC) and its response to surgical interventions for tumor in HBV positive HCC patients.


METHODS
We analyzed HBV marker results and detected HBV DNA in sera of 97 HCC patients (pre-operation 66 cases, post-operation 31 cases) with polymerase chain reaction (PCR) assay. We also investigated the HBV DNA titer in sera before and one week after operation in 20 HCC patients with positive HBV markers by quantitative polymerase chain reaction (Q-PCR).


RESULTS
HBV DNA positive rate in sera was 40.9% and 64.52% in the two subgroup respectively (P < 0.05). HBV DNA titer in sera increased after operation (P < 0.01).


CONCLUSIONS
The infection rate of HBV in Chinese HCC patients is very high. The replication of hepatitis B virus is strong in partial HBV marker positive HCC patients and surgical interventions may promote the virus replication.
Chen
T
T
Department of Surgery, Sun Yat-sen Memorial Hospital, University of Medical Sciences, Guangzhou 510120.
Ou
Q
Q
Chen
J
J
Deng
Q
Q
Zhang
F
F
D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000601:surgery* / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000821:virology*; D006511:Hepatitis B Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000601:surgery* / Q000821:virology; D008297:Male; D013997:Time Factors
D004279:DNA, Viral; D006511:Hepatitis B Antigens