[Growth rate can be manipulated. Estrogen production in pubertal boys can be blocked by an aromatase inhibitor].
A review of a twelve month clinical trial [1] using a new, effective aromatase inhibitor treatment in boys with delayed puberty shows that the pubertal increase in estrogen levels can be blocked, with concomitant preserved pubertal growth rate. Circulating testosterone levels are greatly enhanced during treatment due to increased gonadotrophin secretion. Despite this, bone age maturation is slow leading to an increased final height prognosis (mean 5.1 cm) for the boys treated with aromatase inhibitor.
Hagenäs
Lars
L
Barnendokrinologiska enheten, Astrid Lindgrens barnklinik, Karolinska sjukhuset, Stockholm. lars.hagenas@kbh.ki.se
D000365:Age Determination by Skeleton; D047072:Aromatase Inhibitors; D001827:Body Height / Q000187:drug effects*; D002648:Child; D018849:Controlled Clinical Trials as Topic; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004967:Estrogens / Q000096:biosynthesis* / Q000097:blood; D006062:Gonadotropins / Q000096:biosynthesis; D006128:Growth / Q000187:drug effects*; D006801:Humans; D000077289:Letrozole; D008297:Male; D009570:Nitriles / Q000494:pharmacology*; D011628:Puberty, Delayed / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D011960:Receptors, Estrogen / Q000187:drug effects*; D012016:Reference Values; D013739:Testosterone / Q000097:blood; D014230:Triazoles / Q000494:pharmacology*
D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D004967:Estrogens; D006062:Gonadotropins; D009570:Nitriles; D011960:Receptors, Estrogen; D014230:Triazoles; D013739:Testosterone; D000077289:Letrozole