title: Use of longitudinal data analysis in the determination of a global score for total hip replacement indication in osteoarthritis patients.
abstract: BACKGROUND
  A composite index would help in medical practice for considering total hip replacement (THR) in hip osteoarthritis. In association with other parameters, such as age or general status, this index could serve to objectively determine the time to THR surgery, and might be used as an outcome measure in therapeutic trials. The objective of this study was to propose such an index, taking into account symptomatic, structural and therapeutic variables, and impact on lifestyle.
  
  
  METHODS
  A curve-fitting procedure and a marginal model were used to highlight the average change in the variables over time. A discrete Cox model, with time-dependent covariates. was then performed to study the association between the variables and hip surgery, leading to the construction of a composite index.
  
  
  RESULTS
  The smoothing and fitting analysis suggested takes into account not only the variables, but also the changes in their values during the preceding year, when studying the association between variables and hip surgery. Five covariates were retained in the Cox model, among them only one concerns the changes during the preceding year, showing that the values of the covariates are more important that their changes during the preceding year for THR indication. The coefficients of the model were transformed into new coefficients, so that their sum provided a severity score with individual values 0-100.
  
  
  CONCLUSIONS
  Based on the values of reliable variables recorded during the four last visits, this score can be regarded as a valid index able to objectively help with THR indications. This score might also be used as an outcome measure in therapeutic trials.
authors.affiliation: CNRS/INSERM U88, Saint-Maurice, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Nakache
authors.forename: A
authors.initials: A
authors.lastname: Gueguen
authors.forename: J
authors.initials: J
authors.lastname: Maillefert
authors.forename: M
authors.initials: M
authors.lastname: Dougados
mesh_terms: D000368:Aged; D003627:Data Interpretation, Statistical; D005260:Female; D006622:Hip Prosthesis / Q000706:statistics & numerical data*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000175:diagnosis / Q000601:surgery*; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012306:Risk; D013997:Time Factors