Primary neuroendocrine carcinoma of the liver: an autopsy case.
An autopsy case of primary hepatic neuroendocrine carcinoma is described. A 72-year-old man had a large tumor mass measuring 22 cm in its greatest diameter and localized to the right, left and caudal lobes of the non-cirrhotic liver. Microscopically, the tumor was composed of middle-sized pleomorphic cells organized in ribbons or trabeculae, with scanty intersecting fibrous septae. Immunohistochemically, the tumor cells were positive for multikeratin C11, chromogranin A and synaptophysin. The patient also had metastases in the bone marrow. No alternative primary source of endocrine tumor was detected. The patient died 4 days after presentation.
Kaya
G
G
Institute of Pathology, University Hospital of Lausanne, Switzerland. gkaya@hcuge.ch
Pasche
C
C
Osterheld
M C
MC
Chaubert
P
P
Fontolliet
C
C
D000368:Aged; D014408:Biomarkers, Tumor / Q000737:chemistry; D019046:Bone Marrow Neoplasms / Q000556:secondary*; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry / Q000556:secondary*; D053379:Chromogranin A; D002864:Chromogranins / Q000737:chemistry; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology*; D008297:Male; D016708:Synaptophysin / Q000032:analysis
D014408:Biomarkers, Tumor; D053379:Chromogranin A; D002864:Chromogranins; D016708:Synaptophysin; D007633:Keratins