Vernoguinosterol and vernoguinoside, trypanocidal stigmastane derivatives from Vernonia guineensis (Asteraceae).
Two bitter stigmastane derivatives, vernoguinosterol (1) and vernoguinoside (2), have been isolated from the stem bark of Vernonia guineensis and their structures eludicated using spectroscopic methods. The new compounds exhibit trypanocidal activity.
Tchinda
Alembert T
AT
Department of Chemistry, University of Dschang, Box 67, Dschang, Cameroon.
Tsopmo
Apollinaire
A
Tane
Pierre
P
Ayafor
Johnson F
JF
Connolly
Joseph D
JD
Sterner
Olov
O
D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012855:Sitosterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects*
D012855:Sitosterols; D014344:Trypanocidal Agents; C454561:vernoguinoside; C454560:vernoquinosterol