Effect of dilazep dihydrochloride on serum cardiac troponin T levels in hemodialysis patients.
OBJECTIVE
Cardiac troponin T is a highly sensitive marker for the detection of myocardial injury. We studied whether dilazep dihydrochloride affects cardiac troponin T levels in hemodialysis patients.


METHODS
Our study included 60 hemodialysis patients without symptoms of acute myocardial ischemia. We measured serum cardiac troponin T levels by the Elecsys troponin T assay and randomized 40 hemodialysis patients with left ventricular hypertrophy (LVH) into two treatment groups: a dilazep dihydrochloride group (300 mg/day, n = 20) and a placebo group (n = 20). Treatment was continued for 12 months.


RESULTS
There were no significant differences between pre- and postdialysis cardiac troponin T levels before treatment. LVH was noted in 40 patients out of 60 hemodialysis patients (67%). Cardiac troponin T levels were significantly higher in these patients (0.23 +/- 0.08 microg/l) than in hemodialysis patients without LVH (0.09 +/- 0.03 microg/l). Cardiac troponin T levels were reduced from 0.24 +/- 0.08 to 0.12 +/- 0.06 microg/l (p < 0.01) in patients treated with dilazep dihydrochloride. There were no change in cardiac troponin T levels in patients receiving placebo (from 0.21 +/- 0.08 at baseline to 0.20 +/- 0.07 microg/l).


CONCLUSIONS
Dilazep dihydrochloride may be effective in ameliorating myocardial damage in hemodialysis patients.
Nakamura
Tsukasa
T
Department of Medicine, Misato Junshin Hospital, Tokyo, Japan.
Ushiyama
Chifuyu
C
Osada
Shiwori
S
Ugai
Kazuya
K
Takahashi
Yutaka
Y
Tanaka
Araki
A
Shimada
Noriaki
N
Ebihara
Isao
I
Koide
Hikaru
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004109:Dilazep / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D006435:Renal Dialysis; D020107:Troponin T / Q000097:blood*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D020107:Troponin T; D014665:Vasodilator Agents; D004109:Dilazep