title: Hemodynamic Effects of Dilevalol Following Acute and Long-Term Administration in Normal and Hypertensive Subjects.
abstract: Forearm hemodynamics using pulsed Doppler flowmetry were studied in 12 healthy volunteers and 20 patients with mild to moderate hypertension before and after acute and long-term oral administration of the beta-blocking agent dilevalol. The study was performed using a double-blind design versus placebo. Both 200-mg and 400-mg dosages produced a significant acute blood pressure reduction in normotensive and hypertensive subjects. In hypertensive subjects, forearm vascular resistance was poorly modified, brachial artery diameter decreased significantly but only with long-term administration of the 400-mg dosage. A significant reduction in brachial artery tangential tension was consequently observed. The study provides evidence that Dilevalol produced a significant decrease in blood pressure in normotensive and hypertensive subjects in association with a decrease in brachial artery tangential tension.
authors.affiliation: Therapham Researches, Paris.
authors.forename: A.
authors.initials: A
authors.lastname: Cournot
authors.forename: I.
authors.initials: I
authors.lastname: Merli
authors.forename: J.
authors.initials: J
authors.lastname: Duchier
authors.forename: M.
authors.initials: M
authors.lastname: Safar