Protective effect of allopurinol in the renal ischemia--reperfusion in uninephrectomized rats.
The effect of allopurinol (an inhibitor of xanthine oxidase) on oxidative stress, renal dysfunction, and histologic alterations was evaluated during the renal ischemia--reperfusion in uninephrectomized rats. Renal malondialdehyde and serum creatinine levels significantly increased after renal ischemia--reperfusion. However, the pretreatment with allopurinol demonstrated a protector effect in these parameters. Renal ischemia--reperfusion provoked a significant renal damage in the operated group. Tubular atrophy and interstitial fibrosis were attenuated by allopurinol when given prior to the surgery. In our study, allopurinol had a strong tendency to exert a beneficial effect during renal ischemia--reperfusion in uninephrectomized rats.
Rhoden
E
E
Department of Urology, Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre (FFFCMPA), Rua Jaragua, 370/302, Bairro Bela Vista, RS 90450-140, Porto Alegre, Brazil. ernanirh@terra.com.br
Teloken
C
C
Lucas
M
M
Rhoden
C
C
Mauri
M
M
Zettler
C
C
Bello-Klein
A
A
Barros
E
E
D000493:Allopurinol / Q000627:therapeutic use*; D000818:Animals; D003404:Creatinine / Q000097:blood; D007511:Ischemia / Q000188:drug therapy*; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D015227:Lipid Peroxidation; D008297:Male; D009392:Nephrectomy; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D015424:Reperfusion; D014969:Xanthine Oxidase / Q000502:physiology
D017382:Reactive Oxygen Species; D000493:Allopurinol; D003404:Creatinine; D014969:Xanthine Oxidase