[How can the effectiveness of multimodality therapy concepts be evaluated? From the viewpoint of the pathologist].
Prognostically relevant histopathological grading of tumor regression (grades I-III) is possible, although laborious. Morphological changes after chemotherapy indicate a specific response to treatment with central fibrosis and residual tumor islands in the periphery. Prognostic factors, such as TNM categories, UICC-R status, tumor size, and lymphangiosis, which are not intrinsic part of regression grading still correlate with patient survival.
Becker
K
K
Institut für Pathologie, Technische Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 München.
Fink
U
U
Ott
K
K
Busch
R
R
Siewert
J R
JR
Höfler
H
H
D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D006801:Humans; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000401:mortality / Q000473:pathology / Q000628:therapy; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate