Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains.
The association between the K-variant of the butyrylcholinesterase gene (BCHE-K) and Alzheimer disease (AD) or AD-related neuropathology has been reported to date with conflicting results. Here, we determined in a sample of 521 cases the severity of AD-related neuropathology and the polymorphisms of both BCHE-K and apolipoprotein E (ApoE). Histopathologically, all brains were classified according to procedures permitting differentiation of the evolutionary stages of neurofibrillary tangles (NFTs) and amyloid-beta-protein deposition (A beta-deposits). The results show that the association between BCHE-K and AD-related neuropathology only was limited to homozygotes for the K allele (P=0.036 for NFTs, and P=0.045 for A beta-deposits) at ages > or = 70 years but not 50-69 years. Furthermore, no interaction was apparent between BCHE-K and ApoE.
Ghebremedhin
Estifanos
E
Department of Clinical Neuroanatomy, J.W. Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. ghebremedhin@em.uni-frankfurt.de
Thal
Dietmar R
DR
Schultz
Christian
C
Braak
Heiko
H
D000368:Aged; D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000544:Alzheimer Disease / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D002091:Butyrylcholinesterase / Q000235:genetics* / Q000378:metabolism; D002540:Cerebral Cortex / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000235:genetics / Q000473:pathology; D058225:Plaque, Amyloid / Q000235:genetics / Q000473:pathology; D011110:Polymorphism, Genetic / Q000235:genetics*
D001057:Apolipoproteins E; D002091:Butyrylcholinesterase