The influence of midazolam on plasma concentrations and pharmacokinetic parameters of lidocaine in rabbits.
The object of this study was to investigate the influence of midazolam on the plasma concentrations and pharmacokinetic parameters of lidocaine in rabbits. Lidocaine levels were determined by the immunofluorescence polarization method, using Abbott reagents. After intravenous administration of a combined dose of midazolam (0.2 mg kg(-1)i.v.) with lidocaine (1 mg kg(-1)i.v.) a statistically perceivable decrease of lidocaine concentration, together with an increase of the constant rate of its elimination and reduction of the biological half-life with average time of lidocaine remaining in the system were observed. Midazolam administered intravenously together with lidocaine shortens the residence time of the drug.
Orszulak-Michalak
D
D
Department of Biopharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.
Owczarek
J
J
Wiktorowska-Owczarek
A K
AK
D000759:Adjuvants, Anesthesia / Q000097:blood / Q000494:pharmacology*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D019540:Area Under Curve; D004347:Drug Interactions; D005260:Female; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D008874:Midazolam / Q000097:blood / Q000494:pharmacology*; D011817:Rabbits
D000759:Adjuvants, Anesthesia; D000779:Anesthetics, Local; D008012:Lidocaine; D008874:Midazolam