title: Bone marrow necrosis and refractory HELLP syndrome in a patient with catastrophic antiphospholipid antibody syndrome.
abstract: We describe a 22-year-old woman who developed extensive and fatal bone marrow necrosis along with involvement of liver, lung, and central nervous system during pregnancy in the background of very high titers of antiphospholipid and anti-beta2 glycoprotein antibodies. This case illustrates a rarely recognized, potentially fatal complication of aPL in the setting of pregnancy.
authors.affiliation: Albert Einstein College of Medicine and White Plains Medical Center Bronx New York, USA.
authors.forename: Jayashree
authors.initials: J
authors.lastname: Sinha
authors.forename: Iftikhar
authors.initials: I
authors.lastname: Chowdhry
authors.forename: Sarah
authors.initials: S
authors.lastname: Sedan
authors.forename: Peter
authors.initials: P
authors.lastname: Barland
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D001157:Arterial Occlusive Diseases / Q000209:etiology / Q000473:pathology; D001855:Bone Marrow Diseases / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D002388:Catastrophic Illness; D002544:Cerebral Infarction / Q000209:etiology / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D017359:HELLP Syndrome / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009336:Necrosis; D011247:Pregnancy