title: Intraocular pressure and gonioscopic findings in rural communities mesoendemic and nonendemic for onchoceriasis, Kaduna State, Nigeria.
abstract: OBJECTIVE
  To report on glaucoma-related ocular parameters, namely intraocular pressure and peripheral anterior synechiae, in the presence of onchocercal infection.
  
  
  METHODS
  Two computer-generated random samples of individuals were drawn from communities mesoendemic and nonendemic for onchocerciasis respectively. Applanation tonometry and gonioscopy were carried out on these individuals.
  
  
  RESULTS
  Four hundred and thirty-six and 319 individuals from the mesoendemic and nonendemic communities were examined respectively. The mean intraocular pressure was 1.58 mmHg lower in the individuals from the mesoendemic communities compared with those from the nonendemic communities (p < 0.001) despite the prevalence of peripheral anterior synechiae being higher in the mesoendemic communities. In these communities, there was strong evidence that the prevalence of peripheral anterior synechiae increased with increasing microfilarial load.
  
  
  CONCLUSIONS
  Onchocercal infection produces a low-grade inflammatory process, which may result in a lowering of intraocular pressure despite the formation of peripheral anterior synechiae. Glaucomatous optic nerve damage may therefore not be the primary cause of visual loss in ocular onchocerciasis as this occurs late and is probably preceded by other blinding onchocercal pathology.
authors.affiliation: Moorfields Eye Hospital, London, UK. yyfung@aol.com
authors.forename: Y F
authors.initials: YF
authors.lastname: Yang
authors.forename: S
authors.initials: S
authors.lastname: Cousens
authors.forename: I E
authors.initials: IE
authors.lastname: Murdoch
authors.forename: O E
authors.initials: OE
authors.lastname: Babalola
authors.forename: A
authors.initials: A
authors.lastname: Abiose
authors.forename: B
authors.initials: B
authors.lastname: Jones
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003906:Developing Countries; D019353:Endemic Diseases; D005260:Female; D005901:Glaucoma / Q000175:diagnosis / Q000469:parasitology*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D009854:Onchocerca; D015827:Onchocerciasis, Ocular / Q000150:complications / Q000503:physiopathology*; D012424:Rural Population