title: [Marked reduction of life-threatening ventricular tachyarrhythmias in a critically ill patient by intravenous administration of magnesium sulfate].
abstract: A 90-year-old man with ischemic heart disease underwent an emergent operation for a ruptured abdominal aortic aneurysm. The patient was brought to the operating room in a state of hypovolemic shock, and developed myocardial ischemia and intractable ventricular arrhythmias during the operation. Intensive cardiopulmonary resuscitation including rapid transfusion, external cardiac massage, electrical defibrillation, and extensive use of cardiovascular drugs restored hemodynamic stability temporarily. However, ventricular tachyarrhythmias readily recurred and caused cardiovascular collapse. Despite a normal value of blood ionized magnesium, we administered two grams of magnesium sulfate intravenously, which drastically reduced ventricular arrhythmias. Although a number of reports have shown the effectiveness of magnesium in correcting lethal ventricular arrhythmias, the rank of magnesium administration has not been well established in standard algorithms for arrhythmia therapy. Now that the concentration of ionized magnesium in the blood can be easily measured in clinical settings, its role as an antiarrhythmic agent should be extensively reevaluated.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655.
authors.forename: Kyung-ho
authors.initials: KH
authors.lastname: Chang
authors.forename: Kaori
authors.initials: K
authors.lastname: Uchikoba
authors.forename: Mizuki
authors.initials: M
authors.lastname: Obara
authors.forename: Mieko
authors.initials: M
authors.lastname: Chinzei
authors.forename: Tosinobu
authors.initials: T
authors.lastname: Sumida
authors.forename: Eiko
authors.initials: E
authors.lastname: Arita
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hanaoka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery; D001019:Aortic Rupture / Q000601:surgery; D006801:Humans; D007275:Injections, Intravenous; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D017180:Tachycardia, Ventricular / Q000188:drug therapy*
chemical_list: D000889:Anti-Arrhythmia Agents; D008278:Magnesium Sulfate