Evaluation of somnolence in Parkinson's disease: comparison with age- and sex-matched controls.
The authors found a significantly higher prevalence of daytime somnolence in 201 patients with PD compared with 214 age- and sex-matched healthy control subjects (Epworth Sleepiness Scale score 5.6 vs 4.6). The prevalence of "sleep attacks" (SA) was about seven times higher in patients with PD than in control subjects (13.9% vs 1.9%; p < 0.0005). Multivariate analysis demonstrated that a higher dose of levodopa and longer duration of disease significantly predicted for SA in patients with PD. Epworth Sleepiness Scale scores of > or =10 had 71.4% sensitivity and 88.4% specificity for SA.
Tan
E K
EK
Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore. gnrtek@sgh.com.sg
Lum
S Y
SY
Fook-Chong
S M C
SM
Teoh
M L
ML
Yih
Y
Y
Tan
L
L
Tan
A
A
Wong
M C
MC
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000009:adverse effects*; D006970:Disorders of Excessive Somnolence / Q000139:chemically induced* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010300:Parkinson Disease / Q000188:drug therapy* / Q000453:epidemiology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D017678:Sex Distribution
D000978:Antiparkinson Agents