Subcutaneous epinephrine vs nebulized salbutamol in asthma.
OBJECTIVE
This study was conducted to compare the efficacy of the subcutaneous epinephrine with nebulized salbutamol.


METHODS
Fifty asthmatic children in the age range of 6-14 years were divided into two equal groups. Group I children were given subcutaneous epinephrine and Group II were nebulized with salbutamol. Patients were observed at 15, 20, 30, 60, 120, 180 and 240 minute intervals. Both the groups had comparable mean increase in peak expiratory flow rate (PEFR %) (Group I 27.7 +/- 0.7; Group II 28.8 +/- 0.06, p >0.05).


RESULTS
In Group I there was significant increase in systolic blood pressure, 30 minutes after the start of treatment, however it settled on its own by 60 minutes.


CONCLUSIONS
Both the groups had satisfactory improvement in clinical parameters which continued upto 4 hours after start of treatment. Subcutaneous epinephrine can be safely used if nebulizers are not available.
Sharma
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Department of Pediatrics, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, India. dr_anitasharma@rediffmail.com
Madan
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D000208:Acute Disease; D000293:Adolescent; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage* / Q000009:adverse effects; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D003906:Developing Countries; D004837:Epinephrine / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007279:Injections, Subcutaneous; D011446:Prospective Studies
D000336:Aerosols; D001993:Bronchodilator Agents; D000420:Albuterol; D004837:Epinephrine