title: Creating a bicuspid valve from the aortic wall: a new surgical approach on aortic valve disease (in vitro study).
abstract: We described a new technique (called 'bicuspidization'), which is performed by using autogenous material, without replacement of the aortic valves for the surgical treatment of aortic stenosis and/or insufficiency and tested it in in vitro sheep model. Different stress conditions were simulated by applying three different flow patterns (hemodynamic challenge tests) successively by using a centrifugal pump. It was demonstrated that the competency of the new bicuspid valves was excellent (zero insufficiency). There was a 10-11 mm Hg-increase on trans-valvular gradient comparing the normal hearts. The autogenous bicuspid valve has not blocked the way of the coronary flow in the closed position.
authors.affiliation: Department of Cardiovascular Surgery, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Unal
authors.forename: Cüneyt
authors.initials: C
authors.lastname: Konuralp
authors.forename: Mustafa
authors.initials: M
authors.lastname: Idiz
authors.forename: Murat
authors.initials: M
authors.lastname: Akçar
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000601:surgery; D006439:Hemodynamics; D023421:Models, Animal; D012680:Sensitivity and Specificity; D012756:Sheep; D014656:Vascular Surgical Procedures / Q000379:methods*