PROGINS receptor gene polymorphism is associated with endometriosis.
OBJECTIVE
To investigate the association between the 306-base pair insertion polymorphism in intron G of the progesterone receptor (PROGINS) and endometriosis.


METHODS
Case-control study.


METHODS
Tertiary care center.


METHODS
Ninety-five white women with surgically diagnosed and histologically confirmed endometriosis and 107 white women without endometriosis (controls).


METHODS
Determination of PROGINS was performed by polymerase chain reaction and gel electrophoresis. MAIN OUTCOIME MEASURE(S): Frequency and distribution of the PROGINS allele.


RESULTS
Frequencies of the mutant allele T2 was 0.17 among women with endometriosis and 0.08 among controls (odds ratio, 2.41 [CI, 1.31-4.53]). Homozygosity for allele T2 was present in 3.2% of women with endometriosis and 0.9% of controls.


CONCLUSIONS
PROGINS appears to be associated with endometriosis in white persons.
Wieser
Fritz
F
Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, University of Vienna, Waeringer Guertel 18-20, A-1090 Vienna, Austria.
Schneeberger
Christian
C
Tong
Dan
D
Tempfer
Clemens
C
Huber
Johannes C
JC
Wenzl
Rene
R
D000328:Adult; D016022:Case-Control Studies; D004247:DNA / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D004587:Electrophoresis, Agar Gel; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics*; D018709:Statistics, Nonparametric
D011980:Receptors, Progesterone; D004247:DNA