[Lactulose mannitol ratio in patients after operation].
OBJECTIVE
To study lactulose (lactulose, L) and mannitol (mannitol, M) ratio in urine following operation and investigate the correlation between severity of stress and L/M ratio.


METHODS
20 patients who had received operation were enrolled and each patient was evaluated by APACH II scores. L/M permeability study was performed before the operation and 5 and 10 days after the operation. The L and M concentration was analyzed by HPLC with pulsed electrochemical detection (HPLC-PED). The correlation between L/M ratio and the severity of surgical stress were related.


RESULTS
The L/M ratio before the operation was (0.023 +/- 0.002), increased to (0.042 +/- 0.005) in the 5th post-operative day (P < 0.01), and then returned to (0.024 +/- 0.002) (P > 0.05) compared with pre-operation in the 10th Post-operation. A significant correlation between the severity of stress and the L/M ratio was observed (r = 0.762).


CONCLUSIONS
The L/M ratio was increased 5 days after the operation and the L/M ratio was correlated with severity of operative stress.
Sun
M
M
Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730.
Liu
Y
Y
Liu
W
W
Deng
G
G
Tang
W
W
Jiang
Z
Z
D018806:APACHE; D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007792:Lactulose / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D008353:Mannitol / Q000008:administration & dosage / Q000378:metabolism*; D008875:Middle Aged; D010539:Permeability; D011184:Postoperative Period; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology*
D008353:Mannitol; D007792:Lactulose