The regulation and function of the Id proteins in lymphocyte development.
Helix-loop-helix (HLH) proteins are essential factors for lymphocyte development and function. One class of HLH proteins, the E-proteins, regulate many aspects of lymphocyte maturation, survival, proliferation, and differentiation. E-proteins are negatively regulated by another class of HLH proteins known as the Id proteins. The Id proteins function as dominant negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here we discuss the function and regulation of the Id proteins in lymphocyte development.
Rivera
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R
Division of Biology, 0366, University of California at San Diego, La Jolla, CA 92093, USA. r3@biomail.ucsd.edu
Murre
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C
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D017637:Clonal Deletion; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006182:H-Y Antigen / Q000502:physiology; D018257:Helix-Loop-Helix Motifs; D006410:Hematopoiesis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051798:Inhibitor of Differentiation Protein 1; D051797:Inhibitor of Differentiation Protein 2; D051796:Inhibitor of Differentiation Proteins; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000166:cytology*; D008223:Lymphoma / Q000235:genetics; D020935:MAP Kinase Signaling System; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008954:Models, Biological; D005810:Multigene Family; D009363:Neoplasm Proteins; D011494:Protein Kinases / Q000502:physiology; D012097:Repressor Proteins; D051820:TCF Transcription Factors; D058125:Transcription Factor 7-Like 1 Protein; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000502:physiology
D004268:DNA-Binding Proteins; D006182:H-Y Antigen; C497453:ID1 protein, human; C497450:ID2 protein, human; C490128:ID4 protein, human; C497455:Idb1 protein, mouse; C497452:Idb2 protein, mouse; C086479:Idb4 protein, mouse; D051798:Inhibitor of Differentiation Protein 1; D051797:Inhibitor of Differentiation Protein 2; D051796:Inhibitor of Differentiation Proteins; D009363:Neoplasm Proteins; D012097:Repressor Proteins; D051820:TCF Transcription Factors; C544912:TCF7L1 protein, human; C544913:Tcf7l1 protein, mouse; D058125:Transcription Factor 7-Like 1 Protein; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; C075640:ID3 protein, human; D004247:DNA; D011494:Protein Kinases