Intratympanic gentamicin therapy for persistent vertigo after endolymphatic sac surgery.
OBJECTIVE
To evaluate the role of intratympanic gentamycin therapy (ITGM) in controlling vertigo in patients with refractory Meniere's who have recurrent or persistent vertigo after endolymphatic sac surgery.


METHODS
A retrospective review of 491 patients seen in a university balance clinic between July 1999 and July 2000. Of these, 68 patients had Meniere's disease; 4 patients had recurrent vertigo after endolymphatic sac surgery and were followed for at least 1 year. These 4 patients received a series of ITGM injections. Outcome measures included control of vertigo and audiometric results.


RESULTS
Three of 4 (75%) patients had control of their vertigo with ITGM therapy. The 1 patient who failed ITGM therapy underwent a successful vestibular neurectomy with ultimate control of his vertigo. No patients had progression of their sensorineural hearing loss.


CONCLUSIONS
ITGM therapy can be used to control vertigo in selected patients with Meniere's disease who have persistent vertigo after unsuccessful endolymphatic sac surgery.


CONCLUSIONS
ITGM therapy may reduce the need for vestibular neurectomy in patients with refractory Meniere's disease after endolymphatic sac surgery.
Marzo
Sam J
SJ
Department of Otolaryngology-Head and Neck Surgery, Loyola University of Chicago, Maywood, Illinois 60153, USA. smarzo@luc.edu
Leonetti
John P
JP
D000287:Administration, Topical; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001301:Audiometry, Pure-Tone; D004584:Electronystagmography; D004712:Endolymphatic Sac / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications; D012008:Recurrence; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013063:Speech Discrimination Tests; D013067:Speech Perception; D014432:Tympanic Membrane; D014717:Vertigo / Q000188:drug therapy* / Q000209:etiology*; D014725:Vestibular Nerve / Q000503:physiopathology / Q000601:surgery
D000900:Anti-Bacterial Agents; D005839:Gentamicins