Precordial QT dispersion does not predict inducibility of ventricular tachyarrhythmias at post-revascularization electrophysiologic study.
OBJECTIVE
We tested the hypothesis that revascularization would decrease QT interval dispersion and that QT interval dispersion would predict the outcome of the electrophysiologic study following revascularization.


BACKGROUND
QT interval dispersion may be a measure of the inhomogeneity of ventricular repolarization. The value of the QT interval dispersion for predicting inducibility of ventricular tachyarrhythmias (VT) during electrophysiologic studies after coronary artery revascularization in patients with hemodynamically significant VT is unknown.


RESULTS
QT interval dispersions were measured from electrocardiograms recorded before and after coronary artery revascularization, but before an electrophysiologic study during the same hospitalization. Fifty-six patients (93% male, 65.1 +/- 9.6 years) were studied. QT interval dispersion decreased significantly following revascularization from 69 +/- 31 ms to 53 +/- 23 ms (p=0.002). Inducibility of VT could not be predicted by the QT interval dispersion following revascularization (50 +/- 30 ms in patients with VT induced vs. 58 +/- 25 ms in patients without VT induced at electrophysiologic study; p=0.2). The change in QT interval dispersion with revascularization (-15 +/- 33 ms vs. -17 +/- 46 ms; p=0.9) could not predict VT inducibility. Actuarial survival after 80 months follow-up was similar in the patients in whom VT was induced (82%) and those patients in whom VT was not induced (83%; p=NS).


CONCLUSIONS
Coronary artery revascularization decreased QT interval dispersion in patients with hemodynamically significant VT, but QT interval dispersion was not predictive of inducibility of VT at follow-up electrophysiologic study. Actuarial survival was similar in patients in whom VT was induced and patients in whom VT was not induced.
Raj
Satish R
SR
Division of Cardiology, Foothills Medical Centre and the Cardiovascular Disease Research Group, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1.
Mitchell
L Brent
LB
Wyse
D George
DG
Duff
Henry J
HJ
Sheldon
Robert S
RS
Roach
Daniel
D
Gillis
Anne M
AM
D000368:Aged; D003327:Coronary Disease / Q000175:diagnosis / Q000628:therapy*; D004562:Electrocardiography; D004594:Electrophysiology; D005260:Female; D005500:Follow-Up Studies; D006329:Heart Conduction System / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods; D011336:Probability; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate; D013575:Syncope / Q000175:diagnosis* / Q000401:mortality; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000401:mortality; D016896:Treatment Outcome; D014693:Ventricular Fibrillation / Q000175:diagnosis* / Q000401:mortality