Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during 2 years of therapy.
For a number of antiretroviral drugs, prolonged suppression of viral replication is related to drug exposure. Therefore, it is important to maintain stable concentrations during prolonged therapy. While studies suggest that saquinavir concentrations decrease over time, we show that concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid are stable during 2 years of therapy.
van Praag
Rieneke M E
RM
National Aids Therapy Evaluation Center (NATEC), Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, University of Amsterdam, Amsterdam, The Netherlands.
van Weert
Elisabeth C M
EC
van Heeswijk
Rolf P G
RP
Zhou
Xiao-Jian
XJ
Sommadossi
Jean-Pierre
JP
Jurriaans
Suzanne
S
Lange
Joep M A
JM
Hoetelmans
Richard M W
RM
Prins
Jan M
JM
D000328:Adult; D019380:Anti-HIV Agents / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D019540:Area Under Curve; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D013997:Time Factors
D019380:Anti-HIV Agents