[Effects of recombinant human growth hormone on cortical bone of ovariectomized rats].
OBJECTIVE
To study the effects of recombinant human growth hormone on cortical bone of middle femur and vertebra of variectomized rats.


METHODS
Forty 6 month-old SD rats received low or high dose of growth hormone subcutaneously 3 months after ovariectomy for 8 weeks. Bone density and biomechanical strength of the femur were measured, and the thickness of cortical bone of the middle femur and L(2) vertebra was observed. The results were compared with those in estrogen group.


RESULTS
Growth hormone increased the thickness of cortical bone and biomechanical strength and bone density. Estrogen therapy showed no effects on bone density and biomechanical strength of cortical bone.


CONCLUSIONS
Recombinant human growth hormone can prevent bone loss from cortical bone of ovariectomized rat.
Huang
S
S
Department Orthopaedics of 9th Hospital, Shanghai Second Medical University, Shanghai 200011, China.
Dai
K
K
Tang
T
T
Wang
Y
Y
D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects* / Q000502:physiology; D005260:Female; D019382:Human Growth Hormone / Q000494:pharmacology*; D006801:Humans; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology
D011994:Recombinant Proteins; D019382:Human Growth Hormone