title: Evolution of myelodysplastic syndrome and acute myelogenous leukaemia in children with hepatitis-associated aplastic anaemia.
abstract: In hepatitis-associated aplastic anaemia (HAA), an immune-mediated mechanism is solely responsible for the development of pancytopenia. We retrospectively analysed the clinical outcome of 61 children with HAA, diagnosed between 1988 and 1996. Of 61 patients, 41 did not receive bone marrow transplantation (BMT) and their survival rate at 7 years was 61.4 +/- 9.3%(+/- SE). Five of these 41 patients developed myelodysplastic syndrome (MDS) or acute myelogenous leukaemia (AML) 7-57 months after the diagnosis of HAA. The incidence of MDS/AML in severe HAA patients who did not receive BMT (n = 30, 27.0 +/- 10.8%) appeared to be similar to that of severe idiopathic AA patients (n = 155, 14.7 +/- 3.7%) treated in the same period.
authors.affiliation: First Department of Pediatrics, Toho University School of Medicine, Tokyo, Japan. aohara@med.tohu-u.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Ohara
authors.forename: Seiji
authors.initials: S
authors.lastname: Kojima
authors.forename: Jun
authors.initials: J
authors.lastname: Okamura
authors.forename: Hiroko
authors.initials: H
authors.lastname: Inada
authors.forename: Hisato
authors.initials: H
authors.lastname: Kigasawa
authors.forename: Shigeyoshi
authors.initials: S
authors.lastname: Hibi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tsukimoto
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000276:immunology* / Q000628:therapy / Q000821:virology*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006505:Hepatitis / Q000276:immunology* / Q000401:mortality / Q000628:therapy; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology* / Q000401:mortality / Q000628:therapy; D008297:Male; D009190:Myelodysplastic Syndromes / Q000276:immunology* / Q000401:mortality / Q000628:therapy; D011336:Probability; D012189:Retrospective Studies; D015996:Survival Rate