[Influence of hormonal replacement therapy on bacterial vaginosis in the group of peri- and postmenopausal women].
The aim of the study was to evaluate microbiological biocenosis of the menopausal or postmenopausal women, and women having local hormonal therapy (Ovestin and Ortho-Gynest D). The study group consisted of 123 women (aged 45-72), who underwent clinical examination and microbiological evaluation of vaginal discharge. Miller's and Gramm's methods were used for slide staining and the culture method for growing microorganisms. Classical culture media were used as well as Rogosa culture medium and modified Weinstein medium for Lactobacillus culture in anaerobic conditions. In the microbiological studies before initiation of hormonal therapy, normal biocenosis of the vagina was found in 52 women (42.27%). The other part of the study group had abnormal vaginal biocenosis or had no microorganisms at all. During the hormonal therapy, the group of women with normal biocenosis increased to 53.65% and 62.29% after respectively 3 and 9 months of therapy. Hormonal therapy secured continuity of normal Lactobacillus morphotypes within perimenopausal period. Antimicrobial and hormonal therapies used together provided normalization of vaginal biocenosis in a shorter time. In the group of senile women, the recolonization of vaginal mucosa by Lactobacillus vaginalis was observed.
Kuczyńska
K
K
Instytut Matki i Dziecka, Warszawa.
Wołczyński
S
S
Janucik-Gacuta
M
M
Zbroch
T
T
D000328:Adult; D000368:Aged; D002979:Climacteric; D004964:Estriol / Q000627:therapeutic use*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects* / Q000302:isolation & purification; D008828:Microbiological Techniques; D008875:Middle Aged; D017698:Postmenopause; D013194:Staining and Labeling / Q000379:methods; D013997:Time Factors; D014621:Vagina / Q000382:microbiology*; D014626:Vaginal Smears; D016585:Vaginosis, Bacterial / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology
D004964:Estriol