A rapid colorimetric method for the determination of Losartan potassium in bulk and in synthetic mixture for solid dosage form.
Two new rapid reproducible and economical spectrophotometric methods are described for the determination of Losartan potassium in bulk and in synthetic mixture for solid dosage forms. Both methods are based on the formation of an orange-red and orange ion-pair complex due to the action of Calmagite (CT) and Orange-II (O-II) on Losartan potassium in acidic medium (pH 1.2). Under optimised conditions, they show an absorption maxima at 491 nm (CT) and 486 nm (O-II), with molar absorptivities of 1.74 x 10(3) and 1.75 x 10(3) l mol(-1) cm(-1) and Sandell's sensitivities of 0.2649 and 0.2637 per 0.001 absorbance unit for CT and O-II, respectively. The colour is stable for 5 min after extraction. In both cases Beer's law is obeyed between 10 and 100 microg ml(-1). The proposed method was successfully extended to synthetic mixture for solid dosage forms.
Prabhakar
Anandkumari H
AH
Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M.S. University of Baroda, Gujarat, India.
Giridhar
Rajani
R
D000959:Antihypertensive Agents / Q000032:analysis*; D003124:Colorimetry; D006863:Hydrogen-Ion Concentration; D019808:Losartan / Q000008:administration & dosage / Q000032:analysis*; D012680:Sensitivity and Specificity
D000959:Antihypertensive Agents; D019808:Losartan