title: Of mice and worms: novel insights into ClC-2 anion channel physiology.
abstract: ClC anion channels are found in all major groups of organisms. Recent studies in nematodes and mice suggest that the function and regulation of ClC-2 have been conserved over vast evolutionary time spans. These studies illustrate the experimental advantages of using genomically defined nonmammalian model organisms for characterizing ClC channel functional genomics.
authors.affiliation: Anesthesiology Research Division, Laboratory of Cellular Physiology, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Strange
mesh_terms: D000818:Animals; D000090007:CLC-2 Chloride Channels; D017173:Caenorhabditis elegans / Q000378:metabolism; D018118:Chloride Channels / Q000502:physiology*; D051379:Mice / Q000378:metabolism
chemical_list: D000090007:CLC-2 Chloride Channels; D018118:Chloride Channels