title: Surface immunoglobulin on B lymphocytes as a potential target for specific peptide ligands in chronic lymphocytic leukaemia.
abstract: With the aim of producing unique targets for malignant cells we have identified peptide ligands for the clonal surface immunoglobulin isolated from the B cells of a chronic lymphocytic leukaemia (CLL) patient. The peptides were identified from random-peptide phage-display libraries. The obtained ligands bound specifically to the surface of the target lymphocytes as well as to clonal immunoglobulin in lysate from the same cells. Peptide-based antigen mimotopes may have a future use in targeted therapy of CLL and other B-cell-derived malignancies displaying surface immunoglobulin.
authors.affiliation: Department of Clinical Biochemistry, Roskilde County Hospital, Roskilde, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Buhl
authors.forename: P B
authors.initials: PB
authors.lastname: Szecsi
authors.forename: G G
authors.initials: GG
authors.lastname: Gisselø
authors.forename: C
authors.initials: C
authors.lastname: Schafer-Nielsen
mesh_terms: D000595:Amino Acid Sequence; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology* / Q000378:metabolism; D008024:Ligands; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism; D019151:Peptide Library; D011947:Receptors, Antigen, B-Cell / Q000032:analysis*; D014407:Tumor Cells, Cultured
chemical_list: D008024:Ligands; D010446:Peptide Fragments; D019151:Peptide Library; D011947:Receptors, Antigen, B-Cell