title: [Prevention and treatment of MODS in severely burned patients: an institute based retrospective study].
abstract: OBJECTIVE
  To determine if the preventive and treatment measures developed from basic and clinical research work have any effects on the incidence and outcome of MODS in severely burned patients.
  
  
  METHODS
  657 extensively burned patients (burn size exceeding 30% TBSA) admitted to the clinical department from January 1970 through October 1999 were studied. The morbidity and mortality rates were compared in patient groups hospitalized before and after January 1990 when major preventive and treatment measures began to be extensively executed. These measures consisted of prompt, rapid and adequate fluid resuscitation, restoration of bowel blood supply with anisodamine (654 - 2), use of oxygen free radical scavengers (e.g. mannitol, vitamin C and E), extensive escharectomy during shock stage, early tube feeding, support of organ function, etc.
  
  
  RESULTS
  Before 1990 when very few preventive and treatment measures were applied, the incidence of MODS, 17.3% (64 out of 369), and the death rate 87.5% (56 out of 64). After 1990, with the application of various preventive measures and treatment, the morbidity and mortality rates were reduced to 6.9% (20/288) and 40.0% (8/20), respectively.
  
  
  CONCLUSIONS
  Our results suggest that measures which mitigate or eliminate the predisposing and causative factors of MODS may be salutary in the prevention and treatment of MODS after extensive burn injury.
authors.affiliation: Burn Institute, 304th Hospital, People's Liberation Army, Beijing 100037, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Sheng
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Chai
authors.forename: Z
authors.initials: Z
authors.lastname: Guo
authors.forename: C
authors.initials: C
authors.lastname: Shen
authors.forename: C
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D002056:Burns / Q000150:complications / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005440:Fluid Therapy; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000517:prevention & control*; D018529:Nutritional Support; D012151:Resuscitation; D012189:Retrospective Studies
chemical_list: D016166:Free Radical Scavengers