[Improvement of protein metabolism by glutamine-enriched TPN and growth hormone in recipients of rat small bowel transplantation].
OBJECTIVE
To observe the effect of glutamine-enriched TPN and recombinant human growth hormone (rhGH)on protein metabolism of recipient of rat small bowel transplantation.


METHODS
Twenty four recipients of rat allogeneic heterotopic small bowel transplantation (SD-->Wistar rat) were divided into 4 groups randomly according to the presence or absence of glutamine or rhGH in TPN regimen. Cyclosporine A (CsA) was used as the immunosuppressant. The changes of body weight, nitrogen balance, urinary 3-methyl histidine excretion and plasma albumin level during 14 days after transplantation were observed.


RESULTS
Applications of glutamine-enriched TPN or rhGH decreased the postoperative catabolism of protein of recipients. They promoted protein synthesis and positive nitrogen balance so as to minimize the loss of body weight and correct hypoalbuminemia. They were synergistic to other.


CONCLUSIONS
Glutamine-enriched TPN and rhGH can promote the protein metabolism of rat small bowel transplantation recipients effectively with the use of CsA, so as to improve the recovery of general condition. Their combination may have the synergistic effect.
Zhang
X
X
Team of Graduate Student, Second Military Medical University, People's Liberation Army, Shanghai 200433, China.
Li
J
J
Li
N
N
Li
Y
Y
D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use; D004357:Drug Synergism; D005973:Glutamine / Q000494:pharmacology*; D019382:Human Growth Hormone / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007421:Intestine, Small / Q000637:transplantation*; D008297:Male; D010289:Parenteral Nutrition, Total; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology; D014183:Transplantation, Heterologous
D007166:Immunosuppressive Agents; D011506:Proteins; D011994:Recombinant Proteins; D005973:Glutamine; D019382:Human Growth Hormone; D016572:Cyclosporine