title: Early death of mice cloned from somatic cells.
abstract: Here we report that the lifespan of mice cloned from somatic cells is significantly shorter than that of genotype- and sex-matched controls, most likely due to severe pneumonia and hepatic failure. This finding demonstrates the possibility of long-term deleterious effects of somatic-cell cloning, even after normal birth.
authors.affiliation: Department of Veterinary Science, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.
authors.forename: Narumi
authors.initials: N
authors.lastname: Ogonuki
authors.forename: Kimiko
authors.initials: K
authors.lastname: Inoue
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Noguchi
authors.forename: Kentaro
authors.initials: K
authors.lastname: Tanemura
authors.forename: Osamu
authors.initials: O
authors.lastname: Suzuki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayama
authors.forename: Kunio
authors.initials: K
authors.lastname: Doi
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Ohtomo
authors.forename: Michiko
authors.initials: M
authors.lastname: Satoh
authors.forename: Akira
authors.initials: A
authors.lastname: Nishida
authors.forename: Atsuo
authors.initials: A
authors.lastname: Ogura
mesh_terms: D000818:Animals; D019976:Cloning, Organism; D006822:Hybrid Cells; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D017093:Liver Failure; D051379:Mice; D011014:Pneumonia; D000644:Quaternary Ammonium Compounds / Q000378:metabolism; D016019:Survival Analysis
chemical_list: D000644:Quaternary Ammonium Compounds; D007770:L-Lactate Dehydrogenase