title: [Expression of T cell factor 4 in renal cell carcinoma].
abstract: OBJECTIVE
  To investigate of the transduction of Wnt/Frizzled pathway in nuclei and the function of TCF4 (T Cell Factor) in renal cell carcinoma.
  
  
  METHODS
  TCF4 mRNA are tested through RT-PCR and Northern Blot in renal cancer tissue and renal cancer cell strain (GRC-I).
  
  
  RESULTS
  It has been certificated that TCF4 are expressed in renal cell carcinoma, at the same time, there are some different splice of TCF4 in renal cancer. A new 300bp mutant gene are found.
  
  
  CONCLUSIONS
  TCF4, an important molecular of Wnt/Frizzled pathway, takes part in the formation and progression of renal cell carcinoma, different splice of TCF4 is one of the mechanism.
authors.affiliation: Department of Urology, First Hospital, Beijing Medical University, Beijing 100034, China.
authors.forename: G
authors.initials: G
authors.lastname: Lin
authors.forename: T
authors.initials: T
authors.lastname: Zang
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Xing
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
mesh_terms: D015152:Blotting, Northern; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D051820:TCF Transcription Factors; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors / Q000235:genetics*; D014407:Tumor Cells, Cultured
chemical_list: D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors