title: Use of plasma exchange and heparin during cardiopulmonary bypass for a patient with heparin induced thrombocytopenia: a case report.
abstract: Patients with documented history of heparin-induced thrombocytopenia (HIT) pose a difficult problem during surgery using cardiopulmonary bypass (CPB). Several alternatives to heparin exist, but these products either are not approved for use in the United States or have more side effects than heparin. We report on a patient with documented heparin-induced antibody and left main coronary artery disease who underwent uneventful coronary artery bypass surgery and recovery by using preoperative plasmaphresis and limited use of porcine intestinal heparin during CPB.
authors.affiliation: Division of Cardiothoracic Surgery, University of Arkansas for Medical Sciences, Little Rock 72205-7199, USA.
authors.forename: M
authors.initials: M
authors.lastname: Kajitani
authors.forename: M
authors.initials: M
authors.lastname: Aguinaga
authors.forename: C E
authors.initials: CE
authors.lastname: Johnson
authors.forename: M A
authors.initials: MA
authors.lastname: Scott
authors.forename: T
authors.initials: T
authors.lastname: Antakli
mesh_terms: D000208:Acute Disease; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass; D003327:Coronary Disease / Q000628:therapy; D006493:Heparin / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange; D013577:Syndrome; D013921:Thrombocytopenia / Q000139:chemically induced*; D014481:United States
chemical_list: D000925:Anticoagulants; D006493:Heparin