Coordinate expression of beta1 integrins and their regulator, TGF beta2 at the floor plate of the medulla oblongata is correlated with the crossing of the fibers of olivocerebellar projection in mice.
During embryonic day 11 (E11) to E16, contact-dependent interacting molecules beta1 integrins and their putative regulator TGF beta2 are coordinately expressed at the floor plate in the caudal part of mouse myelencephalon. Their expression disappears at E18. Consistent with the peak of their expression (E13-E16), olivocerebellar fibers primarily cross the floor plate. These data indicate that spatiotemporal expression of beta1 integrins and TGF beta2 is correlated with the crossing of olivocerebellar fibers.
Ohyama
Kyoji
K
Centre for Developmental Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK. k.ohyama@sheffield.ac.uk
Kawamura
Koki
K
D000818:Animals; D019521:Body Patterning / Q000502:physiology; D002232:Carbocyanines; D002454:Cell Differentiation / Q000502:physiology*; D002531:Cerebellum / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D005260:Female; D005333:Fetus; D005456:Fluorescent Dyes; D007839:Functional Laterality / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D007150:Immunohistochemistry; D019012:Integrin beta1 / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D009434:Neural Pathways / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D009847:Olivary Nucleus / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D011247:Pregnancy; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D053781:Transforming Growth Factor beta2
C035005:3,3'-dihexadecylindocarbocyanine; D002232:Carbocyanines; D005456:Fluorescent Dyes; D019012:Integrin beta1; D016212:Transforming Growth Factor beta; D053781:Transforming Growth Factor beta2