Synergistic effect of nicorandil and amlodipine on mitochondrial function during isoproterenol-induced myocardial infarction in rats.
The synergistic effects of nicorandil (KATP-channel opener) and amlodipine (calcium-channel blocker) on heart mitochondrial enzymes and the mitochondrial antioxidant defence system was examined on isoproterenol-induced myocardial infarction in rats. The rats given isoproterenol (150 mg kg(-1) daily, i.p.) for two days showed significant changes in marker enzymes, mitochondrial enzymes and the mitochondrial defence system. Pre-co-treatment with nicorandil (2.5 mg kg(-1) daily, p.o.) and amlodipine (5.0 mg kg(-1) daily, p.o.) for 3 days significantly prevented these alterations and restored enzyme activity to near normal. These findings demonstrate the protective and synergistic effect of nicorandil and amlodipine in combination against isoproterenol-induced cardiac damage.
Sathish
Venkatachalem
V
Department of Biochemistry and Molecular Biology, University of Madras, Chennai, India.
Vimal
Veereshwarayya
V
Ebenezar
Kesavarao Kumar
KK
Devaki
Thiruvengadam
T
D017311:Amlodipine / Q000627:therapeutic use*; D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003402:Creatine Kinase / Q000097:blood; D004357:Drug Synergism; D007545:Isoproterenol / Q000009:adverse effects; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000201:enzymology; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy*; D020108:Nicorandil / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D000637:Transaminases / Q000097:blood; D014665:Vasodilator Agents / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D017311:Amlodipine; D020108:Nicorandil; D007770:L-Lactate Dehydrogenase; D000637:Transaminases; D003402:Creatine Kinase; D007545:Isoproterenol