title: [The treatment of 432 patients with pituitary adenomas via transsphenoidal approach].
abstract: OBJECTIVE
  To study some clinical features of 432 cases of pituitary adenomas treated by transsphenoidal microsurgery between July 1982 and October 1996.
  
  
  METHODS
  Pathological examination, immunohistochemical examination and electronmicroscopic examination were done in 424, 29 and 103 cases respectively.
  
  
  RESULTS
  Hyperprolactinemia was found in many so-called non-functioning adenomas besides in prolactinomas. The dura maters were invaded by tumors in 78 cases (the incidence of dural invasion was 65.5%).
  
  
  CONCLUSIONS
  Hyperprolactinemia is not peculiar to prolactinomas, and differential diagnosis is necessary when hyperprolactinemia exists. The involvement of the dura mater of sellar floor is an important mark that the adjacent tissues were invaded by pituitary adenomas. The outcome of surgical treatment is significantly different between the patients with dural invasion and without invasion.
authors.affiliation: Department of Neurosurgery, General Hospital of Nanjing Military Area, People's Liberation Army, Nanjing 210002.
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
authors.forename: Q
authors.initials: Q
authors.lastname: Tan
authors.forename: J
authors.initials: J
authors.lastname: Shi
authors.forename: K
authors.initials: K
authors.lastname: Sun
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Xie
authors.forename: Y
authors.initials: Y
authors.lastname: Pan
authors.forename: C
authors.initials: C
authors.lastname: Hang
authors.forename: X
authors.initials: X
authors.lastname: Shao
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D000293:Adolescent; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D007016:Hypophysectomy / Q000379:methods*; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010911:Pituitary Neoplasms / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies