title: Effect of dilazep dihydrochloride on serum cardiac troponin T levels in hemodialysis patients.
abstract: OBJECTIVE
  Cardiac troponin T is a highly sensitive marker for the detection of myocardial injury. We studied whether dilazep dihydrochloride affects cardiac troponin T levels in hemodialysis patients.
  
  
  METHODS
  Our study included 60 hemodialysis patients without symptoms of acute myocardial ischemia. We measured serum cardiac troponin T levels by the Elecsys troponin T assay and randomized 40 hemodialysis patients with left ventricular hypertrophy (LVH) into two treatment groups: a dilazep dihydrochloride group (300 mg/day, n = 20) and a placebo group (n = 20). Treatment was continued for 12 months.
  
  
  RESULTS
  There were no significant differences between pre- and postdialysis cardiac troponin T levels before treatment. LVH was noted in 40 patients out of 60 hemodialysis patients (67%). Cardiac troponin T levels were significantly higher in these patients (0.23 +/- 0.08 microg/l) than in hemodialysis patients without LVH (0.09 +/- 0.03 microg/l). Cardiac troponin T levels were reduced from 0.24 +/- 0.08 to 0.12 +/- 0.06 microg/l (p < 0.01) in patients treated with dilazep dihydrochloride. There were no change in cardiac troponin T levels in patients receiving placebo (from 0.21 +/- 0.08 at baseline to 0.20 +/- 0.07 microg/l).
  
  
  CONCLUSIONS
  Dilazep dihydrochloride may be effective in ameliorating myocardial damage in hemodialysis patients.
authors.affiliation: Department of Medicine, Misato Junshin Hospital, Tokyo, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Nakamura
authors.forename: Chifuyu
authors.initials: C
authors.lastname: Ushiyama
authors.forename: Shiwori
authors.initials: S
authors.lastname: Osada
authors.forename: Kazuya
authors.initials: K
authors.lastname: Ugai
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Araki
authors.initials: A
authors.lastname: Tanaka
authors.forename: Noriaki
authors.initials: N
authors.lastname: Shimada
authors.forename: Isao
authors.initials: I
authors.lastname: Ebihara
authors.forename: Hikaru
authors.initials: H
authors.lastname: Koide
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004109:Dilazep / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D006435:Renal Dialysis; D020107:Troponin T / Q000097:blood*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D020107:Troponin T; D014665:Vasodilator Agents; D004109:Dilazep