[Bacterial IgA1-protease: production, properties and prospects for use].
Some pathogenic bacteria have been demonstrated to secrete specific IgA1-proteases, the enzymes cleaving the molecules of the first subclass of human immunoglobulin (IgA1) in the single point from the hinge with the formation of Fab- and Fc-fragments. Cleavage generally deprives immunoglobulins having defense properties and the enzymes are considered as pathogenic factors. How to determine the activity, purification, and the promises of use of IgA-proteases is described. Whether inactivated meningococcal IgA1-protease as a vaccine against any of the five (A, B, C, Y, W135) serotypes of pathogenic meningococci is discussed.
Surovtsev
V I
VI
Fedorov
T V
TV
Gusev
V V
VV
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D006090:Gram-Negative Bacteria / Q000201:enzymology* / Q000472:pathogenicity; D006801:Humans; D006868:Hydrolysis; D007071:Immunoglobulin A, Secretory / Q000737:chemistry / Q000378:metabolism; D016920:Meningitis, Bacterial / Q000517:prevention & control; D011323:Primates; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism*; D014774:Virulence
D001428:Bacterial Vaccines; D007071:Immunoglobulin A, Secretory; D012697:Serine Endopeptidases; C021433:IgA-specific serine endopeptidase