title: Periodontal regeneration with an autogenous bone-Bio-Oss composite graft and a Bio-Gide membrane.
abstract: This study evaluated the clinical, radiographic, and histologic response to the composite use of Bio-Oss porous bone mineral and autogenous bone in combination with a Bio-Gide bilayer collagen membrane to achieve regeneration when treating human periodontal bone defects. Preoperative recordings for four treatment areas included radiographs, clinical probing depths, and attachment levels; these recordings were repeated at 9 months. Histologic evaluation revealed new cementum with inserting collagen fibers and new bone formation on the surface of both types of graft materials. This grafting combination not only compared favorably with the previous use of Bio-Oss and Bio-Gide, but exceeded that result with almost complete periodontal regeneration. This human histologic study demonstrates that autogenous bone in combination with porous bone mineral matrix, together with the Bio-Gide collagen membrane, has the capacity to stimulate substantial new bone and cementum formation with Sharpey's fiber attachment.
authors.affiliation: Brazil Institute for Advanced Dental Studies, Belo Horizonte.
authors.forename: M
authors.initials: M
authors.lastname: Camelo
authors.forename: M L
authors.initials: ML
authors.lastname: Nevins
authors.forename: S E
authors.initials: SE
authors.lastname: Lynch
authors.forename: R K
authors.initials: RK
authors.lastname: Schenk
authors.forename: M
authors.initials: M
authors.lastname: Simion
authors.forename: M
authors.initials: M
authors.lastname: Nevins
mesh_terms: D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery*; D001641:Bicuspid; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001857:Bone Matrix / Q000637:transplantation*; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D003094:Collagen / Q000627:therapeutic use* / Q000648:ultrastructure; D003238:Connective Tissue / Q000473:pathology; D003739:Dental Cementum / Q000473:pathology; D004846:Epithelial Attachment / Q000473:pathology; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use*; D010012:Osteogenesis / Q000502:physiology; D017622:Periodontal Attachment Loss / Q000473:pathology / Q000601:surgery; D010513:Periodontal Ligament / Q000473:pathology; D010514:Periodontal Pocket / Q000473:pathology / Q000601:surgery
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen