title: Bifunctional derivative of p,p'-dichlorochalcone. Part III. Synthesis and study for cytotoxic activity of a new compound, 2-[2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-thiazolidin-4-one from p,p'-dichlorochalcone.
abstract: The synthesis of 2-(2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-thiazolidin-4-one (3) from p,p'-dichlorochalcone (1) via 1,3,3-tris(4-chlorophenyl)-propan-1-one (2) using thioglycollic acid in the presence of ammonium carbonate is described. Structural assignment, stereochemistry and biological assay are discussed.
authors.affiliation: Department of Chemistry, Aligarh Muslim University, Aligarh 202 002, India.
authors.forename: Shishu Pal
authors.initials: SP
authors.lastname: Singh
authors.forename: Wajid Husain
authors.initials: WH
authors.lastname: Ansari
authors.forename: Guy
authors.initials: G
authors.lastname: Lemière
authors.forename: Tim
authors.initials: T
authors.lastname: Jonckers
authors.forename: Roger
authors.initials: R
authors.lastname: Dommisse
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives / Q000737:chemistry*; D047188:Chalcones; D002722:Chlorobenzenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D003432:Cross-Linking Reagents; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D053778:Thiazolidines; D014407:Tumor Cells, Cultured
chemical_list: C456419:2-(2,2-bis(4-chlorophenyl)ethyl)-2-(4-chlorophenyl)thiazolidin-4-one; C456420:4,4'-dichlorochalcone; D000970:Antineoplastic Agents; D047188:Chalcones; D002722:Chlorobenzenes; D003432:Cross-Linking Reagents; D013844:Thiazoles; D053778:Thiazolidines; D002599:Chalcone