title: [RBC and T lymphocyte subsets in patients with bladder carcinoma: immunological study].
abstract: OBJECTIVE
  To study immune function of erythrocytes and the correlation with the change of T lymphocyte subsets in the patients with bladder cancer.
  
  
  METHODS
  The red blood cell C(3)b receptor rate (C(3)bRR), immune complex rate (ICR) and four kinds of tumor erythrocyte rosette tests were determined in 34 cases of bladder transitional epithelial carcinoma. The subsets of T lymphocyte were also determined by using flow cytometry (FCM). 30 non-carcinoma patients that well-matched in age and 20 healthy men were determined for comparison.
  
  
  RESULTS
  The C(3)bRR, four kinds of tumor erythrocyte rosette rate, CD3, CD4 and CD4/CD8 ratio were lower in the bladder transitional epithelial carcinoma group than those of the control group. Meanwhile, ICR and CD8 were significantly elevated (P < 0.01). There was differentiation between G1 patients and G2 patients (P < 0.05). A positive correlation between C3bRR and the radio of CD4/CD8 was noted in the bladder transitional cell carcinoma group.
  
  
  CONCLUSIONS
  Patients with bladder transitional cell carcinoma show lower erythrocyte function and disorder of T lymphocyte subsets. There is a close relationship between red cell immune function and T lymphocyte subsets. The cellular immune function (including the red cell immune function) in patients with poorly differentiated cells is lower.
authors.affiliation: Department of Urology, First Affiliated Hospital of Kunming Medical College, Kunming 650031.
authors.forename: J
authors.initials: J
authors.lastname: Xu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D002295:Carcinoma, Transitional Cell / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D001749:Urinary Bladder Neoplasms / Q000276:immunology*