Chemical impurities in [18F]FDG preparations produced by solid-phase 18F-fluorination.
[18F]FDG was produced by solid-phase 18F-fluorination (resin method) and chemical impurities were determined in the [18F]FDG preparations by ion chromatography. The major chemical impurities were D-glucose (90.5 +/- 6.4 microg/mL), 2-chloro-2-deoxy-D-glucose (11.8 +/- 2.7 microg/mL), and D-mannose (1.7 +/- 0.7 microg/mL), which were expected to be present by considering the synthetic routes. An FDG mass (0.5 +/- 0.2 microg/mL) was also detected in the preparations. No notable radiochemical impurities, including 2-[18F]fluoro-2-deoxy-D-mannose, were detected in the [18F]FDG preparations. Thus, the levels of several chemical impurities were determined in the [18F]FDG preparations produced by solid-phase 18F-fluorination.
Kuge
Yuji
Y
Department of Tracer Kinetics, Graduate School of Medicine, Hokkaido University, Kita 15 Nishi 7, 060-8638, Kita-ku, Sapporo, Japan. kuge@med.hokudai.ac.jp
Nishijima
Ken-ichi
K
Nagatsu
Kotaro
K
Seki
Koh-ichi
K
Ohkura
Kazue
K
Tanaka
Akira
A
Sasaki
Motoji
M
Tsukamoto
Eriko
E
Tamaki
Nagara
N
D002852:Chromatography, Ion Exchange; D020650:Combinatorial Chemistry Techniques; D004340:Drug Contamination; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18 / Q000032:analysis* / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000032:analysis* / Q000138:chemical synthesis*
D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18