title: Predicting novel protein folds by using FRAGFOLD.
abstract: The results of applying a fragment-based protein tertiary structure prediction method to the prediction of 8 CASP4 targets are described. The method is based on the assembly of supersecondary structural fragments taken from highly resolved protein structures using a simulated annealing algorithm. Despite the significant degree of success in this case, there is clearly much more developmental work required before predictions with the accuracy of a good homology model, or even a good fold recognition model, can be made with use of this kind of approach.
authors.affiliation: Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, United Kingdom.
authors.forename: D T
authors.initials: DT
authors.lastname: Jones
mesh_terms: D001430:Bacteriocins / Q000737:chemistry; D003198:Computer Simulation; D008958:Models, Molecular; D010446:Peptide Fragments / Q000737:chemistry; D011487:Protein Conformation; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D020539:Sequence Analysis, Protein; D012984:Software
chemical_list: D001430:Bacteriocins; D010446:Peptide Fragments; C440289:bacteriocin AS-48, Enterococcus faecalis