title: Absence of platelet response after eradication of Helicobacter pylori infection in patients with chronic idiopathic thrombocytopenic purpura.
abstract: Eradication of Helicobacter pylori infection has been associated with the correction of thrombocytopenia in patients with idiopathic thrombocytopenic purpura (ITP). We have analysed the response to eradication of H. pylori in a series of 56 adult patients with chronic ITP. Forty patients had H. pylori infection (71%) that was eradicated in 23 of 32 evaluable patients (72%). Platelet counts did not significantly vary according to H. pylori treatment outcome. Three of 56 patients (5%) achieved a partial response attributable to H. pylori eradication. Therefore, detection of H. pylori infection should not be routinely included in the initial work-up of ITP.
authors.affiliation: Haematology Services, Hospital Universitario La Fe, Av. Campanar. 21, 46009 Valencia, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Jarque
authors.forename: R
authors.initials: R
authors.lastname: Andreu
authors.forename: I
authors.initials: I
authors.lastname: Llopis
authors.forename: J
authors.initials: J
authors.lastname: De la Rubia
authors.forename: F
authors.initials: F
authors.lastname: Gomis
authors.forename: L
authors.initials: L
authors.lastname: Senent
authors.forename: C
authors.initials: C
authors.lastname: Jiménez
authors.forename: G
authors.initials: G
authors.lastname: Martín
authors.forename: J A
authors.initials: JA
authors.lastname: Martínez
authors.forename: G F
authors.initials: GF
authors.lastname: Sanz
authors.forename: J
authors.initials: J
authors.lastname: Ponce
authors.forename: M A
authors.initials: MA
authors.lastname: Sanz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000627:therapeutic use; D017291:Clarithromycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood* / Q000382:microbiology*
chemical_list: D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole