title: Thymidine phosphorylase and dihydropyrimidine dehydrogenase in bladder cancer.
abstract: Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) levels in transitional cell carcinoma of the bladder resected from 38 patients were examined by ELISA. TP levels in high-grade and invasive cancer were significantly higher than those in low-grade and superficial cancer, respectively. No significant differences in the DPD levels were observed among grades and stages, but the DPD/TP ratio was significantly lower in grade 3 tumor than in grade 1. These results demonstrated that 5'-deoxy-5-fluorouridine seemed to be useful for managing patients with grade 3 cancer. The present study also suggested that we might be able to exclude cases of bladder cancer in which 5-fluorouracil group medicines would be inappropriate candidates in treatment options by measuring both TP and DPD levels in the tumor.
authors.affiliation: Department of Urology, Teikyo University School of Medicine, Tokyo, Japan. urology@med.teikyo-u.ac.jp
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Iizumi
authors.forename: Kyouichi
authors.initials: K
authors.lastname: Hariu
authors.forename: Mika
authors.initials: M
authors.lastname: Sato
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sato
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Shimizu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomomasa
authors.forename: Takashi
authors.initials: T
authors.lastname: Umeda
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000201:enzymology*; D042943:Dihydrouracil Dehydrogenase (NADP); D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism*; D013939:Thymidine Phosphorylase / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000201:enzymology*
chemical_list: D000970:Antineoplastic Agents; D010088:Oxidoreductases; D042943:Dihydrouracil Dehydrogenase (NADP); D013939:Thymidine Phosphorylase; D005472:Fluorouracil