Familial oligoasthenoteratozoospermia: evidence of autosomal dominant inheritance with sex-limited expression.
OBJECTIVE
To report the familial occurrence of severe oligoasthenoteratozoospermia in a man and five male relatives related through their mothers.


METHODS
Case report.


METHODS
University medical center.


METHODS
Six affected family members.


METHODS
Blood and semen samples were collected from all affected males and some of their healthy male relatives. Pedigree analysis and exclusion of X-linked disorder were done.


RESULTS
Analysis suggested that familial nonsyndromic male factor infertility was present.


CONCLUSIONS
The family described in this report suggests the existence of an autosomal dominant trait of male infertility with sex-limited expression.
Tuerlings
Joep H A M
JH
Department of Human Genetics, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands. j.tuerlings@antrg.azn.nl
van Golde
Ron J T
RJ
Oudakker
Astrid R
AR
Yntema
Helger G
HG
Kremer
Jan A M
JA
D000328:Adult; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000235:genetics*; D010375:Pedigree