title: Multiple regulation of peptide YY secretion in the digestive tract.
abstract: In the last two decades, multiple aspects of the peptide YY (PYY) secretion have been investigated. Besides fat and fatty acids, many luminal nutrients in the distal intestine appear to induce PYY release. Some studies have shown that bile acid, but not nutrients, plays a crucial role in the regulation of PYY secretion. Moreover, chyme in the proximal intestine also regulates the peptide release by indirect action through humoral and neuronal factors. Gastrin, cholecystokinin, and the vagus nerve are major candidates for mediators of these indirect actions. Several growth factors have been shown to regulate PYY synthesis in mucosa of the distal intestine. This review is aimed at presenting an overview of these recent studies on PYY secretion in the distal intestine.
authors.affiliation: School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan. onaga@rakuno.ac.jp
authors.forename: Takenori
authors.initials: T
authors.lastname: Onaga
authors.forename: Romuald
authors.initials: R
authors.lastname: Zabielski
authors.forename: Seiyu
authors.initials: S
authors.lastname: Kato
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D005285:Fermentation; D005755:Gastrins / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism; D019894:Peptide YY / Q000235:genetics / Q000378:metabolism*; D014018:Tissue Distribution; D014630:Vagus Nerve / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D005755:Gastrins; D019894:Peptide YY; D002766:Cholecystokinin