title: Clinical significance of PEA3 in human breast cancer.
abstract: BACKGROUND
  Recently, PEA3 has been reported to suppress HER-2/neu overexpression by promoter activity and thereby inhibit tumorigenesis of breast cancer both in vitro and in vivo.
  
  
  METHODS
  The expression of PEA3 and the clinicopathologic features of 89 patients with breast cancer were investigated. The expression of PEA3 was immunohistochemically detected in 42 (47.2%) of 89 patients.
  
  
  RESULTS
  The correlation between the expression of PEA3 and the clinicopathologic features were nil with regard to lymph node metastasis, hormone receptor, blood vessel invasion, and lymphatic vessel invasion. The disease-free survival rate was shorter for the PEA3-negative groups than for the PEA3-positive ones, but with no statistically significant difference. The overall survival rate after surgical resection in patients who were PEA3-positive vs PEA3-negative was 100% vs 87.2%, respectively, at 3 years and 89.8% vs 72.7%, respectively, at 6 years (P =.0472).
  
  
  CONCLUSIONS
  The expression of PEA3 in breast cancer might therefore be a novel prognostic factor.
authors.affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Kinoshita
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kitamura
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanaka
authors.forename: Keishi
authors.initials: K
authors.lastname: Sugimachi
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ishida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saeki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D015996:Survival Rate; D014157:Transcription Factors / Q000032:analysis*
chemical_list: D014157:Transcription Factors; C065788:transcription factor PEA3