title: Adapalene gel 0.1% for topical treatment of acne vulgaris in African patients.
abstract: Acne vulgaris is a common dermatologic disease in African patients, as well as in Caucasians. Our report evaluates the safety and efficacy of adapalene gel 0.1% in African patients with acne vulgaris. We used a 12-week, 2-center, open-label, noncomparative study of adapalene gel 0.1% in 65 African patients with acne vulgaris to assess the drug's effect on hyperpigmented lesions in people with dark skin. The study demonstrated that the progressive and significant improvements in lesion counts and global acne grades produced by adapalene in African patients were paralleled by significant improvements in the degree of hyperpigmentation of acne lesions. During treatment with adapalene, less than 5% of patients reported moderate or severe skin irritation at any time during the study, and the incidence of skin oiliness decreased markedly. We conclude that adapalene gel 0.1% was well tolerated and highly effective in African patients with acne vulgaris and was found to reduce hyperpigmentation.
authors.affiliation: Department of Dermatology, University of Pretoria, Republic of South Africa.
authors.forename: W K
authors.initials: WK
authors.lastname: Jacyk
authors.forename: P
authors.initials: P
authors.lastname: Mpofu
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000208:ethnology; D000068816:Adapalene; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009281:Naphthalenes / Q000627:therapeutic use*; D013019:South Africa; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009281:Naphthalenes; D000068816:Adapalene