In vitro activities of BAL9141, a novel broad-spectrum pyrrolidinone cephalosporin, against gram-negative nonfermenters.
The activities of BAL9141 (formerly Ro 63-9141), a novel pyrrolidinone-3-ylidenemethyl cephalosporin, against 244 strains of gram-negative nonfermenters were evaluated. The overall MIC at which 50% of isolates are inhibited (MIC50) and the overall MIC90 were 2 and 64 microg/ml, respectively, which are similar to those of imipenem, lower than those of the other cephalosporins tested, amoxicillin, and the ticarcillin-clavulanic acid combination, and much higher than those of ciprofloxacin. BAL9141 shows species-dependent activity in vitro against a variety of gram-negative nonfermentative pathogens.
Zbinden
R
R
Department of Medical Microbiology, University of Zurich, 8028 Zurich, Switzerland. RZbinden@immv.unizh.ch
Pünter
V
V
von Graevenitz
A
A
D002511:Cephalosporins / Q000494:pharmacology*; D005285:Fermentation; D005947:Glucose / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
D002511:Cephalosporins; C443755:ceftobiprole; D005947:Glucose