title: Relative impact of low-density lipoprotein-cholesterol concentration and insulin resistance on carotid wall thickening in nondiabetic, normotensive volunteers.
abstract: The relative effect of an increase in low-density lipoprotein-cholesterol (LDL-C) concentration, as compared with insulin resistance and its manifestations, on intimal medial thickening (IMT) of the common carotid artery was defined in 72 healthy men and women. Insulin-mediated glucose disposal was quantified by the insulin suppression tests, in which the height of the steady-state plasma glucose (SSPG) concentration during the last 30 minutes of a 180-minute infusion of octreotide, insulin, and glucose provides an estimate of insulin resistance. IMT was determined by high-resolution B-mode ultrasonography. Univariate analyses defined statistically significant correlation coefficients between IMT and LDL-C concentration (r =.25, P <.05), SSPG concentration (r =.32, P <.01), triglycerides (TG) (r =.25, P <.05), and high-density lipoprotein-cholesterol (HDL-C) (r = -.28, P <.05) concentrations (changes associated with insulin resistance) and ratio of waist-to-hip girth (r =.29, P <.05). When forward step-wise linear regression analysis was used, concentrations of SSPG, LDL-C and HDL-C all emerged as independent predictors of IMT (P <.05). Furthermore, the magnitude of their relationship to IMT values was comparable. These results provide evidence that insulin resistance is as significant a predictor of degree of atherogenesis (estimated by IMT) of the common carotid artery as a high LDL-C concentration.
authors.affiliation: Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC.
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Wang
authors.forename: Chia-Wei
authors.initials: CW
authors.lastname: Liou
authors.forename: Shan-Tair
authors.initials: ST
authors.lastname: Wang
authors.forename: Hock-Liow
authors.initials: HL
authors.lastname: Eng
authors.forename: Rue-Tsuan
authors.initials: RT
authors.lastname: Liu
authors.forename: Shih-Chen
authors.initials: SC
authors.lastname: Tung
authors.forename: Wen-Yen
authors.initials: WY
authors.lastname: Chien
authors.forename: Yung-Chuan
authors.initials: YC
authors.lastname: Lu
authors.forename: Ming-Chun
authors.initials: MC
authors.lastname: Kuo
authors.forename: Ching-Jung
authors.initials: CJ
authors.lastname: Hsieh
authors.forename: Cheng-Hsiung
authors.initials: CH
authors.lastname: Chen
authors.forename: Jung-Fu
authors.initials: JF
authors.lastname: Chen
authors.forename: James W
authors.initials: JW
authors.lastname: Chu
authors.forename: Gerald M
authors.initials: GM
authors.lastname: Reaven
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002339:Carotid Arteries / Q000473:pathology*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D003920:Diabetes Mellitus / Q000473:pathology; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D012016:Reference Values; D017539:Tunica Intima / Q000473:pathology*
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL