Lewis acid promoted highly stereoselective rearrangement of 2,3-aziridino alcohols: a new efficient approach to beta-amino carbonyl compounds.
A new Lewis acid promoted rearrangement reaction of 2,3-aziridino alcohols was discovered, which involved the highly stereoselective construction of a diastereogenic quaternary carbon center and efficient formation of beta-amino carbonyl compounds in excellent yields. A wide variety of Lewis acids were proved to be effective for the reaction, and a possible reaction mechanism was also discussed.
Wang
Bao Min
BM
Department of Chemistry and National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Song
Zhen Lei
ZL
Fan
Chun An
CA
Tu
Yong Qiang
YQ
Shi
Yian
Y