title: Effect of Calcium Entry Blocking Agents (Nifedipine and Verapamil) on Myocardial Recovery during Reperfusion.
abstract: A comparative study on isolated guinea pig hearts was carried out to determine the effect of calcium entry blocking agents: nifedipine- and verapamil-added reperfusion solutions on myocardial recovery after global ischemia. After 20 min of normothermic ischemia, three groups of solutions were used for reperfusion (10 animals each): (1) Nifedipine-added (10--8 mmol L(minus sign1)) Krebs--Henseleit solution; (2) verapamil-added (10--8 mmol L(minus sign)) Krebs-Henseleit solution; (3) Krebs--Henseleit solution. Postischemic myocardial functions (ventricular contractile force and heart work) and enzyme activities were compared with their preischemic values. The addition of calcium entry blocking agents does not have any significant advantage over control solutions in myocardial recovery.
authors.affiliation: Gazi University, School of Medicine Ankara, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Gökgöz
authors.forename: Serdar
authors.initials: S
authors.lastname: Gunaydin
authors.forename: Oguz
authors.initials: O
authors.lastname: Tatlican
authors.forename: Avni
authors.initials: A
authors.lastname: Babacan
authors.forename: Velit
authors.initials: V
authors.lastname: Halit
authors.forename: Aydin
authors.initials: A
authors.lastname: Oğuz
authors.forename: Cemal
authors.initials: C
authors.lastname: Cevik
authors.forename: Hakan
authors.initials: H
authors.lastname: Aydin
authors.forename: Ozlem
authors.lastname: Yavuz
authors.forename: Halim
authors.initials: H
authors.lastname: Soncul