title: Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones.
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 USA. kcn@scripps.edu
authors.forename: K C
authors.initials: KC
authors.lastname: Nicolaou
authors.forename: K
authors.initials: K
authors.lastname: Namoto
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: A
authors.initials: A
authors.lastname: Ritzén
authors.forename: T
authors.initials: T
authors.lastname: Ulven
authors.forename: M
authors.initials: M
authors.lastname: Shoji
authors.forename: D
authors.initials: D
authors.lastname: Zaharevitz
authors.forename: R
authors.initials: R
authors.lastname: Gussio
authors.forename: D L
authors.initials: DL
authors.lastname: Sackett
authors.forename: R D
authors.initials: RD
authors.lastname: Ward
authors.forename: A
authors.initials: A
authors.lastname: Hensler
authors.forename: T
authors.initials: T
authors.lastname: Fojo
authors.forename: P
authors.initials: P
authors.lastname: Giannakakou
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D034261:Epothilones; D006801:Humans; D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology*; D008854:Microscopy, Electron; D008958:Models, Molecular; D013237:Stereoisomerism; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014404:Tubulin / Q000378:metabolism / Q000648:ultrastructure; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; C113666:C12,13-cyclopropylepothilone A; C452199:C12,C13-cyclobutylepothilone A; D034261:Epothilones; D007202:Indicators and Reagents; D007783:Lactones; D013844:Thiazoles; D014404:Tubulin