title: Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin.
abstract: Numerous analogues of the naturally occurring antibiotic althiomycin have been synthesised exploiting both total- and semi-synthetic methodologies. The antibacterial activity of these derivatives has been determined in whole cell assays and indicates the natural product exhibits a restricted SAR.
authors.affiliation: GlaxoSmithKline SpA, Medicines Research Centre, Via Fleming 4, 37135, Verona, Italy. pz29728@gsk.com
authors.forename: Paola
authors.initials: P
authors.lastname: Zarantonello
authors.forename: Colin P
authors.initials: CP
authors.lastname: Leslie
authors.forename: Rafael
authors.initials: R
authors.lastname: Ferritto
authors.forename: Wieslaw M
authors.initials: WM
authors.lastname: Kazmierski
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013844:Thiazoles; C010018:althiomycin