title: Late results of isolated mitral annuloplasty for "functional" ischemic mitral insufficiency.
abstract: BACKGROUND
  Repair of functional ischemic mitral regurgitation (MR) due to annular deformity and leaflet restriction remains a challenge for the surgeon and lacks well-documented outcomes. We investigated outcomes in the treatment of functional ischemic MR corrected by annuloplasty techniques alone.
  
  
  METHODS
  From May 1980 to July 1999, 174 patients underwent repair for functional ischemic mitral insufficiency with annuloplasty alone (128 ring annuloplasty; 46 suture annuloplasty). Acute insufficiency was present in 25 (14.4%). Concomitant procedures included CABG (n = 152; 87.4%). Patients were studied longitudinally with annual follow-up and echocardiograms.
  
  
  RESULTS
  Overall hospital mortality was 17.8% and was increased by NYHA Class 4 (23.8% vs. 8.7%; p = 0.011), diabetes (25.0% vs. 13.6%; p = 0.059), and chronic mitral insufficiency (16.4% vs. 8.0%; p = 0.070). Multivariate analysis revealed age (beta = 0.099; p = 0.049) and ejection fraction < 30% (beta = 1.260; p = 0.097) as significant predictors of hospital death. Mean postoperative mitral insufficiency was 0.84 +/- 0.86 (scale of 0-4). NYHA Class 4 (beta = 2.33; p = 0.034) and simple suture annuloplasty (beta = 2.08; p = 0.07) were associated with increased risk of late cardiac death. Cumulative incidence of mitral reoperation was 7.7% at 5 years. At follow-up, 89.7% of patients were in NYHA Class 1 or 2 with 83.4% having none or only mild mitral insufficiency.
  
  
  CONCLUSIONS
  Ring annuloplasty is associated with a survival benefit when compared to simple suture repair in ischemic patients who require annuloplasty alone to correct the MR. Mitral reconstruction with a ring annuloplasty offers durable results in this homogeneous subset of functional ischemic MR patients. Ischemic mitral insufficiency is associated with significant late mortality.
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, New York University School of Medicine, New York 10016, USA. grossi@cv.med.nyu.edu
authors.forename: E A
authors.initials: EA
authors.lastname: Grossi
authors.forename: C S
authors.initials: CS
authors.lastname: Bizekis
authors.forename: A
authors.initials: A
authors.lastname: LaPietra
authors.forename: C C
authors.initials: CC
authors.lastname: Derivaux
authors.forename: A C
authors.initials: AC
authors.lastname: Galloway
authors.forename: G H
authors.initials: GH
authors.lastname: Ribakove
authors.forename: A T
authors.initials: AT
authors.lastname: Culliford
authors.forename: R A
authors.initials: RA
authors.lastname: Esposito
authors.forename: J
authors.initials: J
authors.lastname: Delianides
authors.forename: S B
authors.initials: SB
authors.lastname: Colvin
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000150:complications* / Q000401:mortality / Q000601:surgery*; D015999:Multivariate Analysis; D017202:Myocardial Ischemia / Q000150:complications* / Q000401:mortality / Q000601:surgery*; D012307:Risk Factors; D012720:Severity of Illness Index; D016019:Survival Analysis; D013536:Suture Techniques / Q000401:mortality; D013997:Time Factors; D016896:Treatment Outcome