title: Chemical impurities in [18F]FDG preparations produced by solid-phase 18F-fluorination.
abstract: [18F]FDG was produced by solid-phase 18F-fluorination (resin method) and chemical impurities were determined in the [18F]FDG preparations by ion chromatography. The major chemical impurities were D-glucose (90.5 +/- 6.4 microg/mL), 2-chloro-2-deoxy-D-glucose (11.8 +/- 2.7 microg/mL), and D-mannose (1.7 +/- 0.7 microg/mL), which were expected to be present by considering the synthetic routes. An FDG mass (0.5 +/- 0.2 microg/mL) was also detected in the preparations. No notable radiochemical impurities, including 2-[18F]fluoro-2-deoxy-D-mannose, were detected in the [18F]FDG preparations. Thus, the levels of several chemical impurities were determined in the [18F]FDG preparations produced by solid-phase 18F-fluorination.
authors.affiliation: Department of Tracer Kinetics, Graduate School of Medicine, Hokkaido University, Kita 15 Nishi 7, 060-8638, Kita-ku, Sapporo, Japan. kuge@med.hokudai.ac.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kuge
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Nishijima
authors.forename: Kotaro
authors.initials: K
authors.lastname: Nagatsu
authors.forename: Koh-ichi
authors.initials: K
authors.lastname: Seki
authors.forename: Kazue
authors.initials: K
authors.lastname: Ohkura
authors.forename: Akira
authors.initials: A
authors.lastname: Tanaka
authors.forename: Motoji
authors.initials: M
authors.lastname: Sasaki
authors.forename: Eriko
authors.initials: E
authors.lastname: Tsukamoto
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
mesh_terms: D002852:Chromatography, Ion Exchange; D020650:Combinatorial Chemistry Techniques; D004340:Drug Contamination; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18 / Q000032:analysis* / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000032:analysis* / Q000138:chemical synthesis*
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18