title: Uterine artery Doppler at 11-14 weeks of gestation in chromosomally abnormal fetuses.
abstract: OBJECTIVE
  To determine whether the major chromosomal abnormalities are associated with impaired placentation in the first trimester of pregnancy.
  
  
  METHODS
  This was a prospective study of 692 singleton pregnancies undergoing fetal karyotyping at 11-14 weeks of gestation. Uterine artery Doppler was carried out and the mean pulsatility index was calculated just before chorionic villus sampling.
  
  
  RESULTS
  The fetal karyotype was normal in 613 pregnancies and abnormal in 79, including 39 cases of trisomy 21, 11 of trisomy 18, 11 of trisomy 13, eight of Turner syndrome and 10 with other defects. There were no significant differences in the median value of uterine artery mean PI between any of the individual groups. Although in the combined group of trisomy 18, trisomy 13 and Turner syndrome fetuses, the median pulsatility index (1.60) was significantly higher than in the chromosomally normal group (median pulsatility index, 1.51; P = 0.021), in the majority of abnormal fetuses (24 of 30) mean pulsatility index was below the 95th centile of the normal group (mean pulsatility index, 2.34). There was no significant association between uterine artery mean pulsatility index and fetal nuchal translucency thickness or fetal growth deficit.
  
  
  CONCLUSIONS
  The high intrauterine lethality and fetal growth restriction associated with the major chromosomal abnormalities are unlikely to be the consequence of impaired placentation in the first trimester of pregnancy.
authors.affiliation: Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, Denmark Hill, London SE5 8RX, UK.
authors.forename: R
authors.initials: R
authors.lastname: Bindra
authors.forename: P
authors.initials: P
authors.lastname: Curcio
authors.forename: S
authors.initials: S
authors.lastname: Cicero
authors.forename: A
authors.initials: A
authors.lastname: Martin
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D025063:Chromosome Disorders / Q000000981:diagnostic imaging*; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging; D005865:Gestational Age; D006801:Humans; D007621:Karyotyping; D021041:Placental Circulation; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011446:Prospective Studies; D011673:Pulsatile Flow; D014314:Trisomy; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D014599:Uterus / Q000098:blood supply