title: [Second primary tumors following treatment of squamous cell carcinoma of the oral cavity].
abstract: In the hospital of the Free University in Amsterdam (the Netherlands) 727 patients with primary squamous cell carcinoma of the oral cavity and lip have been studied for the incidence of second primary tumors occurring in the respiratory and upper digestive tract. Out of the 727 patients, 74 (10.2%) developed a second primary tumor in these tracts. The incidence of second primary tumors was expressed per 1.000 person-years of follow-up; 28 second primary tumors per 1.000 person-years of follow-up were seen in the respiratory and upper digestive tract. The patients ran the risk of developing a second primary tumor at a steady rate of approximately 2.8% per year during at least ten years. Furthermore, an increasing incidence of second primary tumors could be observed in case of increasing use of tobacco.
authors.affiliation: Afdeling Mondziekten en Kaakchirurgie en Orale Pathologie, Academisch Ziekenuis Vrije Universiteit/Academisch Centrum voor Tandheelkunde Amsterdam (ACTA).
authors.forename: I G
authors.initials: IG
authors.lastname: van der Tol
authors.forename: A
authors.initials: A
authors.lastname: Jovanovic
authors.forename: E A
authors.initials: EA
authors.lastname: Schulten
authors.forename: P J
authors.initials: PJ
authors.lastname: Kostense
authors.forename: N
authors.initials: N
authors.lastname: de Vries
authors.forename: G B
authors.initials: GB
authors.lastname: Snow
authors.forename: I
authors.initials: I
authors.lastname: van der Waal
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008048:Lip Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000628:therapy*; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000209:etiology; D009426:Netherlands / Q000453:epidemiology; D012907:Smoking / Q000009:adverse effects