[Serum levels of soluble CD30 molecule in hepatitis B virus infection].
BACKGROUND
The release of CD30 molecule in the soluble form (sCD30) is considered a feature of Th2 activation and proliferation of the cellular phenotype Th2.


OBJECTIVE
To analyze the immunoregulatory role of sCD30 in the evolution of hepatitis B virus (HBV) infection.


METHODS
Three study groups were formed: 15 patients with acute infection by HBV who remitted toward the resolution of the infection; 15 patients who evolved to the carrier state and 15 subjects without clinical history of infection by this or other viruses. The determination of serological markers for the HBV was done by the Microparticles Enzymatic Immunoanalysis techniques (MEIA). The method of double antibody by ELISA was used For sCD30 determination.


RESULTS
A significant sCD30 increase (p < 0.05) was observed in patients with acute infection, during the acute phase (135.7 +/- 36.7). These values decreased to 16.2 +/- 2.5 during the convalescent phase. Patients that evolved to the carrier state, did not experience a rise in sCD30 values (40.2 +/- 6.7, 38 +/- 9.2 and 36.1 +/- 8.3 during the acute phase, at 120 and 240 days respectively). The value in the control group was 34.8 +/- 6.7.


CONCLUSIONS
The group that evolved towards remission experienced a higher activation of the Th2 cellular phenotype, promoting humoral immune response. An inactivity of sCD30 values was observed in the group that evolved to the carrier state.
Monsalve
F
F
Laboratorio Regional de Referencia Virológica, Cátedra de Virologia, Escuela de Bioanálisis, División de Estudios para Graduados, Facultad de Medicina, Universidad del Zulia, Maracaibo-Venezuela. francisca_castillo@hotmail.com
Romero-A
T
T
Estévez
J
J
Costa
L
L
Callejas
D
D
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000276:immunology*; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood*; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D017730:Ki-1 Antigen