title: [Results of a phase I clinical trial of "theraphthal + ascorbic acid" catalytic system].
abstract: Phase-I clinical studies of teraphtal and a "teraphtal + ascorbic acid" catalytic system have been completed. The dose-limiting toxicity and maximum tolerable dose were not reached even at the end of maximal dose trials. No side-effects characteristic of antitumor cytostatic drugs were registered. The gravest side-effect ever recorded was a collapse which could not be linked to teraphtal dosage and was probably caused by hypersensitivity to the drug. The drug was recommended for phase II trials.
authors.forename: A M
authors.initials: AM
authors.lastname: Garin
authors.forename: V A
authors.initials: VA
authors.lastname: Gorbunova
authors.forename: M L
authors.initials: ML
authors.lastname: Gershanovich
authors.forename: L V
authors.initials: LV
authors.lastname: Manziuk
authors.forename: A G
authors.initials: AG
authors.lastname: Borodkina
authors.forename: V V
authors.initials: VV
authors.lastname: Breder
authors.forename: O B
authors.initials: OB
authors.lastname: Karmanovskaia
authors.forename: G N
authors.initials: GN
authors.lastname: Zubrikhina
authors.forename: A V
authors.initials: AV
authors.lastname: Madzhuga
authors.forename: N I
authors.initials: NI
authors.lastname: Zimakova
authors.forename: N N
authors.initials: NN
authors.lastname: Trapeznikov
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000188:drug therapy; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy; D003110:Colonic Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy; D008297:Male; D008545:Melanoma / Q000188:drug therapy; D008875:Middle Aged; D012509:Sarcoma / Q000188:drug therapy; D012878:Skin Neoplasms / Q000188:drug therapy; D012983:Soft Tissue Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; C403768:theraphthal