title: Reoviruses and the host cell.
abstract: Reovirus infection of target cells can perturb cell cycle regulation and induce apoptosis. Differences in the capacity of reovirus strains to induce cell cycle arrest at G1 and G2/M have been mapped to the viral S1 genome segment, which also determines differences in the ability of reovirus strains to induce apoptosis and to activate specific mitogen-activated protein kinase (MAPK) cascades selectively. Reovirus-induced apoptosis involves members of the tumor necrosis factor (TNF) superfamily of death receptors and is associated with activation of both death receptor- and mitochondrial-associated caspases. Reovirus infection is also associated with the activation of a variety of transcription factors, including nuclear factor (NF)-kappaB. Junctional adhesion molecule (JAM) has recently been identified as a novel reovirus receptor. Reovirus binding to JAM appears to be required for induction of apoptosis and activation of NF-kappaB, although the precise cellular pathways involved have not yet been identified.
authors.affiliation: Dept of Neurology, University of Colorado Health Sciences Center, Campus Box B-182, 4200 E, 9th Avenue, Denver, CO 80262, USA. Ken.Tyler@UCHSC.edu
authors.forename: K L
authors.initials: KL
authors.lastname: Tyler
authors.forename: P
authors.initials: P
authors.lastname: Clarke
authors.forename: R L
authors.initials: RL
authors.lastname: DeBiasi
authors.forename: D
authors.initials: D
authors.lastname: Kominsky
authors.forename: G J
authors.initials: GJ
authors.lastname: Poggioli
mesh_terms: D000818:Animals; D017209:Apoptosis; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002453:Cell Cycle; D006790:Host-Parasite Interactions; D062726:Junctional Adhesion Molecules; D051379:Mice; D011991:Receptors, Virus / Q000378:metabolism*; D012087:Reoviridae / Q000502:physiology*; D012088:Reoviridae Infections / Q000235:genetics* / Q000382:microbiology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules; D062726:Junctional Adhesion Molecules; D011991:Receptors, Virus; D014157:Transcription Factors