Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset.
Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.
Bonifati
Vincenzo
V
Department of Clinical Genetics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands. bonifati@kgen.fgg.eur.nl
Breedveld
Guido J
GJ
Squitieri
Ferdinando
F
Vanacore
Nicola
N
Brustenghi
Pierluigi
P
Harhangi
Biswadjiet S
BS
Montagna
Pasquale
P
Cannella
Milena
M
Fabbrini
Giovanni
G
Rizzu
Patrizia
P
van Duijn
Cornelia M
CM
Oostra
Ben A
BA
Meco
Giuseppe
G
Heutink
Peter
P
D000328:Adult; D017668:Age of Onset; D002878:Chromosomes, Human, Pair 1; D005192:Family Health; D005260:Female; D006801:Humans; D008025:Ligases / Q000235:genetics; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000235:genetics*; D010375:Pedigree; D044767:Ubiquitin-Protein Ligases
D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D008025:Ligases