Safety of lyophilized SAG2 oral rabies vaccine in collared lemmings.
Fifteen collared lemmings (Dicrostonyx groenlandicus) were exposed to a lyophilized oral rabies vaccine designed to immunize wild carnivore populations. No animals contracted rabies from the vaccine as determined by the absence of clinical signs after 37 days and lack of rabies virus in brain tissue determined by the fluorescent antibody (FA) test. These results suggest that collared lemmings would not contract rabies if they ingested this lyophilized vaccine in the wild during bait vaccination programs for arctic foxes (Alopex lagopus).
Follmann
Erich H
EH
Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska 99775-7000, USA. ffehf@uaf.edu
Ritter
Donald G
DG
Hartbauer
Donald W
DW
D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D003411:Arvicolinae; D001921:Brain / Q000821:virology; D005455:Fluorescent Antibody Technique; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000276:immunology; D011820:Rabies virus / Q000276:immunology*; D012376:Rodent Diseases / Q000517:prevention & control*; D012449:Safety
D000914:Antibodies, Viral; D011819:Rabies Vaccines