[Linkage disequilibrium study of microsatellite markers on chromosome 6 and schizophrenia].
OBJECTIVE
To explore the relationship between the microsatellite markers on chromosome 6 and schizophrenia by linkage disequilibrium analysis.


METHODS
Twenty-eight microsatellite markers on chromosome 6 were evaluated in 115 affected-sib-pair and trios families. Linkage disequilibrium analysis was conducted according to diagnostic categories, Positive and Negative Syndrome Scale (PANSS) and other clinical data by XDT and MAPMAKER/SIBS software system.


RESULTS
Significant P value (P<0.005) was found in all the four diagnostic categories. Only the locus of D6S1960 showed positive P value (P<0.05) in all the subgroups divided by PANSS scale and the age of onset.


CONCLUSIONS
The area around D6S1960 in short arm of chromosome 6 may contain susceptibility gene of schizophrenia.
Deng
Hong
H
Institute of Mental Health, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. xieheliu@hotmail.com
Liu
Xiehe
X
Cai
Guiqing
G
Terwedow
Henry
H
Wang
Zhaoxi
Z
Xu
Xin
X
D017668:Age of Onset; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*