Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum.
The C-4 sulfated isoflavonoid, torvanol A (1), and the steroidal glycoside, torvoside H (3), together with the known glycoside, torvoside A (2), were isolated from a MeOH extract of Solanum torvum fruits. Upon enzymatic hydrolysis with beta-glucosidase, torvoside A (2) and torvoside H (3) yielded the corresponding acetal derivatives 4 and 5, respectively. Torvanol A (1), torvoside H (3) and compound 5 exhibited antiviral activity (herpes simplex virus type 1) with IC(50) values of 9.6, 23.2 and 17.4 microg/ml, respectively. Compounds 1-5 showed no cytotoxicity (at 50 microg/ml) against BC, KB and Vero cell lines.
Arthan
Damrongkiet
D
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Svasti
Jisnuson
J
Kittakoop
Prasat
P
Pittayakhachonwut
Daraporn
D
Tanticharoen
Morakot
M
Thebtaranonth
Yodhathai
Y
D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D005638:Fruit / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D019657:Solanaceae / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000998:Antiviral Agents; D006027:Glycosides; D007529:Isoflavones; D013256:Steroids; C454585:torvanol A; C454583:torvaside H; C454584:torvoside A