title: Liver adenoma and focal nodular hyperplasia associated with oral contraceptives.
abstract: We report the case of a woman, with a 15-year history of high-dosage oral contraceptive use, who came to our center for a gynecological screening. Elevated liver enzymes were detected in blood samples and an abdominal ultrasound showed a hypoechogenic nodular image of 8 cm in the right hepatic lobe of the liver. Routine examinations, including hepatitis B surface antigen, hepatitis C viral antibody and alpha-fetoprotein, were all negative. Imaging studies, including computerized tomography scan, magnetic resonance imaging, sulfur colloid gammagraphy and hepatic angiography, were performed and confirmed the presence of the lesion, detecting the characteristic central scar structure of focal nodular hyperplasia. Discontinuation of oral contraceptives and follow-up showed no change in lesion size so that a surgical approach was adopted in order to remove the hepatocellular carcinoma. Pathological findings confirmed focal nodular hyperplasia.
authors.affiliation: Obstetrics and Gynecology Department, Clínico Universitario Lozano Blesa, Zaragoza, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Tajada
authors.forename: J
authors.initials: J
authors.lastname: Nerín
authors.forename: M M
authors.initials: MM
authors.lastname: Ruiz
authors.forename: M
authors.initials: M
authors.lastname: Sánchez-Dehesa
authors.forename: E
authors.initials: E
authors.lastname: Fabre
mesh_terms: D018248:Adenoma, Liver Cell / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D000328:Adult; D000792:Angiography; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D003276:Contraceptives, Oral