title: The clinical entity of remitting seronegative synovitis with pitting edema (RS3PE syndrome).
abstract: Remitting seronegative symmetrical synovitis with pitting edema is a clinical entity distinct from polymyalgia rheumatica arthritis appearing in elderly patients. Distal pitting edema and tenosynovitis of the digitorum tendons are characteristically seen in this disorder. In contrast to polymyalgia rheumatica and rheumatoid arthritis, treatment with low-dose glucocorticoids usually produces a prompt and enduring remission after several months. Follow-up evaluations are necessary not only to assure this diagnosis is posterior, but also to observe for the possible occurrence of associated neoplasms.
authors.affiliation: Department of Internal Medicine, West Virginia University School of Medicine, Charleston Division, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Triplett
authors.forename: A K
authors.initials: AK
authors.lastname: Pfister
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004487:Edema / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D011241:Prednisone / Q000627:therapeutic use; D013577:Syndrome; D013717:Tenosynovitis / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D011241:Prednisone