Increased intra-articular concentration of bradykinin in the temporomandibular joint changes the sensitivity of muscle spindles in dorsal neck muscles in the cat.
The aim of the present study was to investigate to what extent activation of bradykinin-sensitive nerve endings of the temporomandibular joint (TMJ) might induce changes in the muscle spindles output from neck muscles through reflex effects on cervical fusimotor neurones. To this end, 26 muscle spindle afferents (MSAs) emanating from the trapezius and splenius muscles of the anaesthetised cat (alpha-chloralose, initial dosage 60 mg/kg) were recorded during injection of Bradykinin (BK) (12.5-50 microg/ml) in the ipsilateral TMJ. Fifteen (58%) MSAs exhibited statistically significant fusimotor effects to injection of BK into the TMJ. Of the 15, ten MSAs showed a response related to activation of static fusimotor neurones, three MSAs showed a response related to an activation of both static and dynamic fusimotor neurones and two MSAs showed a inhibition of both static and dynamic fusimotor neurones. The control experiments suggests that the effects observed were due to activation of BK sensitive nerve endings in the TMJ. It seems possible that the reflex connections between TMJ nociceptors and the fusimotor-muscle spindle system of dorsal neck muscles might be involved in the pathophysiological mechanisms responsible for the sensory-motor disturbances in the neck region often found on patients with temporomandibular disorders.
Hellström
Fredrik
F
Centre for Musculoskeletal Research, National Institute for Working Life, Box 7654, S-907 13 Umeå, Sweden.
Thunberg
Johan
J
Bergenheim
Mikael
M
Sjölander
Per
P
Djupsjöbacka
Mats
M
Johansson
Håkan
H
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology / Q000502:physiology*; D002415:Cats; D007270:Injections, Intra-Articular; D009470:Muscle Spindles / Q000187:drug effects / Q000502:physiology*; D009334:Neck Muscles / Q000187:drug effects / Q000502:physiology*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D013704:Temporomandibular Joint / Q000187:drug effects / Q000502:physiology*
D001920:Bradykinin