title: Severe pulmonary toxicity in a patient treated with gemcitabine.
abstract: Gemcitabine is a pyrimidine analog of deoxycytidine with activity against nonhematologic and hematologic malignancies. Its pulmonary toxicity is usually mild and self-limiting. We describe a male patient with lung cancer in whom severe dyspnea and interstitial infiltrates developed after the administration of gemcitabine.
authors.affiliation: Department of Medicine, Jackson Memorial Hospital, University of Miami School of Medicine, 1611 NW 12th Avenue, Miami, FL 33136-1094, U.S.A.
authors.forename: Manuel F
authors.initials: MF
authors.lastname: Rosado
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Kett
authors.forename: Roland M H
authors.initials: RM
authors.lastname: Schein
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Baraona
authors.forename: Kasi S
authors.initials: KS
authors.lastname: Sridhar
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D003841:Deoxycytidine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D004417:Dyspnea / Q000139:chemically induced; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology; D008297:Male; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine