Effect of Acanthopanax senticosus stem on mast cell-dependent anaphylaxis.
We studied the effect of Acanthopanax senticosus stem (ACPS) on mast cell-dependent anaphylaxis. ACPS inhibited compound 48/80-induced systemic anaphylaxis at a dose of 1.0 g/kg by 50%. ACPS also inhibited passive cutaneous anaphylaxis reaction and histamine release from mast cells in a dose-dependent manner, respectively. Moreover, ACPS had an inhibitory effect on anti-dinitrophenyl IgE-induced tumor necrosis factor-alpha (TNF-alpha) production from mast cells. These results indicate that ACPS inhibits mast cell-mediated anaphylaxis in vivo and in vitro murine model.
Yi
Jin Mu
JM
Department of Oriental Pharmacy, College of Pharmacy, Korea Institute of Oriental Pharmacy, Wonkwang University, Iksan, Chonbuk 570-749, South Korea.
Hong
Seung Heon
SH
Kim
Jong Ha
JH
Kim
Hyeong Kyun
HK
Song
Ho Joon
HJ
Kim
Hyung Min
HM
D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D028001:Eleutherococcus / Q000502:physiology*; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018547:Plant Stems / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D010936:Plant Extracts; D003189:p-Methoxy-N-methylphenethylamine