Expression of bile duct-type cytokeratin in hepatocellular carcinoma in patients with hepatitis C virus and prior hepatitis B virus infection.
The clinicopathologic findings in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) positive for biliary markers, those related to the hepatic progenitor cells, were investigated. Cytokeratin (CK) 19 was reactive for HCCs only in patients with prior hepatitis B virus (HBV) infection. The proportions of patients with prior HBV infection and poorly differentiated HCC were significantly higher among those with CK 19-positive HCC than among those with CK 19-negative HCC. Some HCCs develop from the hepatic progenitor cells in patients with HCV infection and prior HBV infection, which may affect the clinicopathologic findings of HCV-related HCCs.
Uenishi
Takahiro
T
Department of Gastroenterological and Hepato-biliary-pancreatic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
Kubo
Shoji
S
Hirohashi
Kazuhiro
K
Yamamoto
Takatsugu
T
Ogawa
Masao
M
Tanaka
Hiromu
H
Shuto
Taichi
T
Kinoshita
Hiroaki
H
D000368:Aged; D001652:Bile Ducts / Q000378:metabolism* / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006509:Hepatitis B / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D006511:Hepatitis B Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000276:immunology; D006526:Hepatitis C / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000378:metabolism*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D015996:Survival Rate
D006511:Hepatitis B Antigens; D012367:RNA, Viral; D007633:Keratins