[Cytochrome P450 2C19 gene polymorphism in four Chinese nationality populations].
OBJECTIVE
To study the cytochrome P450 2C19(CYP2C19) gene polymorphism in 4 Chinese nationality populations.


METHODS
The genotypes of the unrelated Miao, Buyi, Tu and Dulong subjects were analyzed by polymerase chain reaction and restriction fragment length polymorphism (RFLP).


RESULTS
CYP2C19*2 allele frequencies were 0.291, 0.329, 0.315 and 0.349 in Miao, Buyi, Tu and Dulong population, respectively. The four populations were consistent with Hardy-Weinberg expectations (P>0.05).


CONCLUSIONS
The frequencies of CYP2C19*2 were in agreement with those of other published data on Asian, but were different from those data on European and African.
Zhang
Song
S
National Research Institute for Family Planning, Beijing, 100081 P. R. China. Zhsong2@hotmail.com
Dong
Zhaowen
Z
Tang
Li
L
Zhou
Qiang
Q
Wu
Zhanpeng
Z
D001189:Aryl Hydrocarbon Hydroxylases; D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D002681:China / Q000208:ethnology; D065731:Cytochrome P-450 CYP2C19; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D006899:Mixed Function Oxygenases / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D044465:White People / Q000235:genetics
D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19