Stroke associated with alpha blocker therapy for benign prostatic hypertrophy.
Benign enlargement of the prostate is a malady of older males, reaching an estimated prevalence of 90% in patients aged over 70 years. Many of these patients are treated with alpha blockers, which can lower blood pressure significantly. We report on a 64-year-old man who developed a right hemiparesis after taking one dose of doxazosin 4 mg for prostatic symptoms. A CT scan of the brain and carotid ultrasound studies were normal. He recovered most of his neurological function within a few days. Ambulatory blood pressure monitoring on doxazosin 2 mg revealed a striking sleep blood pressure reduction.
Mansoor
George A
GA
Section of Hypertension, University of Connecticut Health Center, Farmington 06030-3940, USA.
Tendler
Beatriz E
BE
D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D017292:Doxazosin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D020521:Stroke / Q000139:chemically induced*
D000317:Adrenergic alpha-Antagonists; D017292:Doxazosin