[Measurement of T and DHT contents in normal and diseased human prostate tissues].
OBJECTIVE
To measure T and DHT contents in normal and diseased human prostate tissues.


METHODS
Serum and prostatic T and DHT levels were measured in patients with normal, benign prostatic hyperplasia and prostate cancer.


RESULTS
A decline was observed in serum T level, but no change in DHT concentration with aging. There were no significant differences in both blood T and DHT levels between the patients with BPH or PCA and normal controls. Serum T level remained constant. There were excessive accumulation of DHT in BPH, and cancerous prostate tissues were responsible for the pathogenesis of BPH and PCA. Finasteride treatment did not produce a reduction in prostatic DHT content.


CONCLUSIONS
More than one form of 5a-reductases is responsible for the high level of DHT in the gland.
Zhang
Y
Y
Huashan Hospital, Shanghai Medical University, Shanghai 200040, China.
Ye
L
L
Ding
Q
Q
Fang
Z
Z
Yao
M
M
Shi
D
D
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D013196:Dihydrotestosterone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*; D011863:Radioimmunoassay; D013739:Testosterone / Q000097:blood / Q000378:metabolism*
D013196:Dihydrotestosterone; D013739:Testosterone