Molecular cloning, gene localization, and structure of human cyclin B3.
Here we describe the molecular cloning of human cyclin B3, its localization, and its structure. It is localized in the subcentromeric region of the X chromosome, still not completely sequenced by the Human Genome Project. This cyclin B3 is unusually large for a mitotic cyclin. Its mRNAs were found in all tissues and were particularly abundant in testis. At least three splice variants were found in the ORF and three variants in the 5'UTR.
Lozano
Jean-Claude
JC
Laboratoire Arago, CNRS-UMR 7628/Université Paris VI, Banyuls-sur-mer, France.
Perret
Eric
E
Schatt
Philippe
P
Arnould
Cécile
C
Peaucellier
Gérard
G
Picard
André
A
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D019926:Cyclin B / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics*; D016213:Cyclins / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics*; D005091:Exons; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007438:Introns; D008297:Male; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000096:biosynthesis; D016415:Sequence Alignment; D013737:Testis / Q000378:metabolism; D014018:Tissue Distribution; D014960:X Chromosome
C503694:CCNB3 protein, human; D019926:Cyclin B; D016213:Cyclins; D012333:RNA, Messenger