title: The effects of repeated dosing with 7.5% sodium chloride/6% dextran following uncontrolled intra-abdominal hemorrhage.
abstract: The use of hypertonic saline Dextran (HSD) for resuscitation following trauma has many potential benefits, especially for the treatment of military casualties, but there is very limited data on the responses following multiple dosing with this fluid. The effects of a second dose of hypertonic saline dextran for resuscitation of uncontrolled intra-abdominal haemorrhage were studied in an experimental model. Under general anaesthesia, 17 large white pigs (weight range, 48-67 kg) were subjected to uncontrolled hemorrhage produced by a tear in the common iliac artery. This resulted in a significant (P < 0.01) reduction of both mean arterial pressure (MAP) and cardiac index. One hour after injury, animals were assigned to one of three groups, receiving either no resuscitation (Group A), or two doses of HSD (at a dose rate of 4 mL/kg), administered either 1 and 4 h after injury (Group B) or 1 and 7 h after injury (Group C). Animals were monitored for 12 h post-injury. A second infusion of HSD caused a significant hypernatremia and diuresis (P< 0.01) in both Groups B and C. There was a non-significant rise in MAP in both treatment groups, and in Group B only, there was a significant increase in cardiac index (P= 0.014). It is concluded that repeat administration of HSD for the resuscitation of uncontrolled hemorrhage results in limited cardiovascular improvements, but that the metabolic sequelae are potentially detrimental to survival.
authors.affiliation: Biomedical Sciences, DERA Porton Down, Salisbury, Wiltshire, United Kingdom.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Stapley
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Clasper
authors.forename: Claudine L
authors.initials: CL
authors.lastname: Horrocks
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Kenward
authors.forename: Paul E
authors.initials: PE
authors.lastname: Watkins
mesh_terms: D000818:Animals; D003911:Dextrans / Q000008:administration & dosage*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics; D006982:Hypertonic Solutions / Q000008:administration & dosage*; D019344:Lactic Acid / Q000097:blood; D012964:Sodium / Q000097:blood; D012965:Sodium Chloride / Q000008:administration & dosage*; D015996:Survival Rate; D013552:Swine; D014554:Urination
chemical_list: D003911:Dextrans; D006982:Hypertonic Solutions; C104375:hypertonic saline-dextran solution; D019344:Lactic Acid; D012965:Sodium Chloride; D012964:Sodium