title: In vitro antiviral effect of flavonoid-rich extracts of Vitex polygama (Verbenaceae) against acyclovir-resistant herpes simplex virus type 1.
abstract: Extracts and fractions rich in flavonoids from fruits and leaves of Vitex polygama Cham. (Verbenaceae) were tested against acyclovir-resistant herpes simplex virus type 1 (ACV-HSV-1). Both fruit and leaf extracts exhibited a dose-dependent antiviral activity. The extract from the leaves showed intracellular antiviral activity while the extract from the fruits had virucidal effect. A fraction from the ethyl actetate extract of the leaves inhibited virus propagation by blocking HEp-2 cell receptors.
authors.affiliation: Instituto de Microbiologia Professor Paulo de Góes, Departamento de Virologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: J L
authors.initials: JL
authors.lastname: Gonçalves
authors.forename: S G
authors.initials: SG
authors.lastname: Leitão
authors.forename: F D
authors.initials: FD
authors.lastname: Monache
authors.forename: M M
authors.initials: MM
authors.lastname: Miranda
authors.forename: M G
authors.initials: MG
authors.lastname: Santos
authors.forename: M T
authors.initials: MT
authors.lastname: Romanos
authors.forename: M D
authors.initials: MD
authors.lastname: Wigg
mesh_terms: D000212:Acyclovir / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D014407:Tumor Cells, Cultured; D020950:Vitex
chemical_list: D000998:Antiviral Agents; D005419:Flavonoids; D010936:Plant Extracts; D000212:Acyclovir