Effect of topical betaxolol on the acute rise of aqueous flare induced by highly selective agonists for prostaglandin E2 receptor subtypes in pigmented rabbits.
OBJECTIVE
To evaluate the role of topical betaxolol on experimental ocular inflammation in rabbits.


METHODS
Transcorneal diffusion of highly selective agonists for prostaglandin E2 receptor subtypes (EP), 25 microg/ml, with the use of a glass cylinder, was performed to produce aqueous flare elevation in pigmented rabbits. Betaxolol was topically administered before EP agonist application. Aqueous flare was measured with a laser flare cell meter.


RESULTS
Performing topical instillation of 0.5% betaxolol 4 times inhibited 52 +/- 9% of EP2-agonist (ONO-AE1-259-01)-induced aqueous flare elevation. The inhibition of flare elevation was dependent on the number of betaxolol instillations. Betaxolol did not suppress the elevation induced by an EP4 agonist (ONO-AE1-392).


CONCLUSIONS
Betaxolol inhibited EP2-agonist-induced aqueous flare elevation in pigmented rabbits.
Yanagisawa
Shuichiro
S
Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan.
Hayasaka
Seiji
S
Zhang
Xue-Yun
XY
Hayasaka
Yoriko
Y
Nagaki
Yasunori
Y
Kitagawa
Kiyotaka
K
D000208:Acute Disease; D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D015784:Betaxolol / Q000008:administration & dosage / Q000627:therapeutic use*; D018916:Blood-Aqueous Barrier; D008297:Male; D011817:Rabbits; D018078:Receptors, Prostaglandin E / Q000819:agonists* / Q000378:metabolism; D058307:Receptors, Prostaglandin E, EP2 Subtype; D058309:Receptors, Prostaglandin E, EP4 Subtype; D014606:Uveitis, Anterior / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*
D000319:Adrenergic beta-Antagonists; D018078:Receptors, Prostaglandin E; D058307:Receptors, Prostaglandin E, EP2 Subtype; D058309:Receptors, Prostaglandin E, EP4 Subtype; D015784:Betaxolol