title: A solid-phase route to N-cyanoamides.
abstract: [reaction: see text] A new method for the solid-phase synthesis of cyanamides is described. The attachment of a secondary amine to solid support is accomplished using Merrifield resin. After functionalization, cleavage is readily achieved with cyanogen bromide to afford the desired cyanamide.
authors.affiliation: Celltech R&D Ltd., Granta Park, Great Abington, Cambridge CB1 6GS, UK.
authors.forename: Trevor
authors.initials: T
authors.lastname: Morgan
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Ray
authors.forename: David M
authors.initials: DM
authors.lastname: Parry
mesh_terms: D002384:Catalysis; D003488:Cyanogen Bromide; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D009570:Nitriles / Q000138:chemical synthesis*; D011759:Pyrrolidines / Q000138:chemical synthesis*
chemical_list: D015853:Cysteine Proteinase Inhibitors; D007202:Indicators and Reagents; D009570:Nitriles; D011759:Pyrrolidines; D003488:Cyanogen Bromide