title: N-alkyl-3-decarboxy-3-hydroxymethylsiastatin B, a new family of glycosidase inhibitors of gem-diamine 1-N-iminosugars.
abstract: N-Alkyl-3-decarboxy-3-hydroxymethylsiastatin B, N-alkyl analogues of gem-diamine 1-N-iminosugars, is a new family of glycosidase inhibitors that have been synthesized from siastatin B isolated from Streptomyces culture. These compounds were evaluated as glycosidase inhibitors.
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: K I
authors.initials: KI
authors.lastname: Kondo
authors.forename: H
authors.initials: H
authors.lastname: Adachi
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000473:Alkanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005688:Galactosamine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D007097:Imines / Q000737:chemistry; D050112:Imino Pyranoses; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D000473:Alkanes; D004791:Enzyme Inhibitors; D007097:Imines; D050112:Imino Pyranoses; C449199:N-acetyl-D-galactosamine-type gem-diamine-1-N-iminosugar; D010880:Piperidines; C011353:siastatin; D005688:Galactosamine; D006026:Glycoside Hydrolases