title: A highly active Suzuki catalyst for the synthesis of sterically hindered biaryls: novel ligand coordination.
abstract: A catalyst system for the preparation of biaryls containing four ortho substituents via Suzuki coupling is described. The combination of a catalytic quantity of Pd2(dba)3 with either an electron-rich biarylphosphine or DPEPhos is effective using a wide range of substrates. The X-ray crystal structure of (dba)Pd(2-(9-phenanthryl)phenyl-dicyclohexylphosphine), in which the Pd is coordinated to the 9,10-double bond of the phenanthryl group, is also reported.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Jingjun
authors.initials: J
authors.lastname: Yin
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Rainka
authors.forename: Xiao-Xiang
authors.initials: XX
authors.lastname: Zhang
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis*; D010720:Phosphines / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001643:Bridged Bicyclo Compounds; D006841:Hydrocarbons, Aromatic; D010720:Phosphines