Clinical and metabolic effects of two lipid emulsions on the parenteral nutrition of septic patients.
OBJECTIVE
We compared the metabolic and clinical effects of two lipid emulsions, long-chain triacylglycerols (LCT) and a mixture of medium- and long-chain triacylglycerols (MCT/LCT), in septic patients.


METHODS
Both groups received total parenteral nutrition (TPN) with a solution enriched with branched-chain amino acids (BCAA). Seventy-two septic patients received TPN with MCT/LCT (group 1) or LCT (group 2). Before starting TPN (basal) and 10 d after (final), various parameters were evaluated.


RESULTS
Twenty-six subjects in each group completed the study. Both groups showed an increase in cholestasis enzymes, with no significant changes in lipid parameters. The rise of retinol-binding protein and the recovery of nitrogen balance were significantly greater in group 1. A multivariate analysis of nutritional markers and catabolic parameters showed a better evolution in group 1 (P = 0.002). The MCT/LCT group exhibited a significant increase of insulin levels. Overall mortality and length of stay in the intensive care unit were not affected by the lipid emulsion.


CONCLUSIONS
In septic patients who received TPN with a solution enriched with BCAAs, the use of an emulsion containing MCT provided them with a greater recovery of their nutrition status than the traditional LCT formula, without influencing the outcome.
Garnacho-Montero
J
J
Intensive Care Unit, Hospital Universitario Virgen del Rocio, Sevilla, Spain. jgmrji@arrakis.es
Ortiz-Leyba
C
C
Jiménez-Jiménez
F J
FJ
Garcia-Garmendia
J L
JL
Jiménez-Jiménez
L M
LM
Garnacho-Montero
M C
MC
Barrero-Almodóvar
A
A
D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D011446:Prospective Studies; D018805:Sepsis / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D016896:Treatment Outcome; D014280:Triglycerides / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism
D005217:Fat Emulsions, Intravenous; D014280:Triglycerides