title: Effect on bone healing of bone morphogenetic protein placed in combination with endosseous implants: a pilot study in beagle dogs.
abstract: Although dental implants have become an effective treatment modality for the replacement of missing teeth, their predictability relies on successful osseointegration during the healing period. The purpose of this pilot study was to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on early bone formation within the perforations of dental implants in beagle dogs. Histologic sections were evaluated for the extent of new bone formation within a 1-mm diameter of through-and-through perforations. Data indicated that significantly more bone formation occurred with rhBMP-2-treated sites within the implant perforation (P < 0.01) compared to sites treated with the vehicle alone. This pilot study indicates that rhBMP-2 increases the rate and extent of bone formation in combination with dental implants.
authors.affiliation: Department of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA. joseph_fiorellini@hms.harvard.edu
authors.forename: J P
authors.initials: JP
authors.lastname: Fiorellini
authors.forename: D
authors.initials: D
authors.lastname: Buser
authors.forename: E
authors.initials: E
authors.lastname: Riley
authors.forename: T H
authors.initials: TH
authors.lastname: Howell
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004285:Dogs; D005260:Female; D006801:Humans; D008334:Mandible / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D008747:Methylcellulose; D023421:Models, Animal; D016348:Osseointegration; D010012:Osteogenesis / Q000187:drug effects; D014677:Pharmaceutical Vehicles; D010865:Pilot Projects; D011897:Random Allocation; D011994:Recombinant Proteins; D013223:Statistics as Topic; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D015921:Dental Implants; D014677:Pharmaceutical Vehicles; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D008747:Methylcellulose