Microwave induced synthesis and antibacterial activity of cephalosporin derivatives using solid support.
Reaction of 7-amino-3-[5'-methyl-1',3',4'-thiadiazol-2'-ylthiomethyl]cephalo-sporanic acid with heterocyclic amines using basic alumina under microwave irradiation (MWI) afforded new cephalosporin analogs in shorter reaction time with improved yield as compared to conventional heating. All the synthesised compounds were tested for their in vitro antibacterial activity, using cefotaxime and cephalothin as reference drugs. All compounds showed significant in vitro antibacterial activity against E. herbicola, P. vulgaries, and Z. mobilis.
Kidwai
M
M
Department of Chemistry, University of Delhi, Delhi, 110007, India. mkidwai@mantraonline.com
Sapra
P
P
Bhushan
K R
KR
Misra
P
P
Saxena
R K
RK
Gupta
R
R
Singh
M
M
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D013830:Thiadiazoles