Antidepressant use during lactation.
Depression commonly affects women, particularly during their childbearing years. Often, pharmacologic therapy is the recommended treatment. Today, medication selection generally involves the newer antidepressants, with tricyclic antidepressant and monoamine oxidase inhibitors reserved for more refractory patients. Although there is ample evidence to support the benefits of breastfeeding in the infant, the scientific literature contains little information with regard to the transfer of antidepressants from the plasma into breast milk and the subsequent effects on the developing infant. Secondary to this lack of safety data, many clinicians and mothers are reluctant to breastfeed during antidepressant treatment. This article will review the literature for reports of the newer antidepressants' use during lactation.
Winans
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Psychiatric Clinical Research Center, University of Illinois, University of Illinois College of Pharmacy, Department of Psychiatry, 1601 W. Taylor, 4th Floor, Chicago, IL 60612, USA.
D000328:Adult; D000928:Antidepressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019052:Depression, Postpartum / Q000188:drug therapy*; D004350:Drug Residues / Q000009:adverse effects / Q000032:analysis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007774:Lactation / Q000187:drug effects / Q000378:metabolism; D008895:Milk, Human / Q000737:chemistry*; D012449:Safety
D000928:Antidepressive Agents