title: Cycloartane glycosides from the rhizomes of Cimicifuga racemosa and their cytotoxic activities.
abstract: Phytochemical analysis of the rhizomes of Cimicifuga racemosa (Ranunculaceae) resulted in the isolation of twelve cycloartane glycosides (1--12), including four new ones (4--6, 12). The structures of the new compounds were determined by spectroscopic analysis, including two-dimensional (2D) NMR data, and chemical methods. The isolated compounds were evaluated for their cytotoxic activities against human oral squamous cell carcinoma (HSC-2) cells and normal human gingival fibroblasts (HGF).
authors.affiliation: Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Watanabe
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Mimaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakagami
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sashida
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D002648:Child; D005260:Female; D005881:Gingiva / Q000166:cytology; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D029626:Ranunculaceae / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes; D014407:Tumor Cells, Cultured
chemical_list: D006027:Glycosides; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C085352:cycloartane