title: New pyrrolizidinone antibiotics CJ-16,264 and CJ-16,367.
abstract: Two new antibiotics, CJ-16,264 (I) and CJ-16,367 (II), were isolated from the fermentation broth of an unidentified fungus CL39457. These antibiotics have a pyrrolizidinone skeleton, first discovered in fungi. Compounds I and II inhibit the growth of Gram-positive multi-drug resistant bacteria and some Gram-negative strains such as Moraxella catarrhalis and Escherichia coli with altered permeability (imp). Comparison of an antibacterial profile between the two compounds suggested that the gamma-lactone portion of I is important for the activity.
authors.affiliation: Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. Yutaka.Sugie@japan.pfizer.com
authors.forename: Y
authors.initials: Y
authors.lastname: Sugie
authors.forename: H
authors.initials: H
authors.lastname: Hirai
authors.forename: H
authors.initials: H
authors.lastname: Kachi-Tonai
authors.forename: Y J
authors.initials: YJ
authors.lastname: Kim
authors.forename: Y
authors.initials: Y
authors.lastname: Kojima
authors.forename: Y
authors.initials: Y
authors.lastname: Shiomi
authors.forename: A
authors.initials: A
authors.lastname: Sugiura
authors.forename: A
authors.initials: A
authors.lastname: Sugiura
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Yoshikawa
authors.forename: L
authors.initials: L
authors.lastname: Brennan
authors.forename: J
authors.initials: J
authors.lastname: Duignan
authors.forename: L H
authors.initials: LH
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Sutcliffe
authors.forename: N
authors.initials: N
authors.lastname: Kojima
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D005285:Fermentation; D005658:Fungi / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; C447443:CJ-16,246; C447444:CJ-16,367; D007783:Lactones; D011758:Pyrroles