A highly active Suzuki catalyst for the synthesis of sterically hindered biaryls: novel ligand coordination.
A catalyst system for the preparation of biaryls containing four ortho substituents via Suzuki coupling is described. The combination of a catalytic quantity of Pd2(dba)3 with either an electron-rich biarylphosphine or DPEPhos is effective using a wide range of substrates. The X-ray crystal structure of (dba)Pd(2-(9-phenanthryl)phenyl-dicyclohexylphosphine), in which the Pd is coordinated to the 9,10-double bond of the phenanthryl group, is also reported.
Yin
Jingjun
J
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Rainka
Matthew P
MP
Zhang
Xiao-Xiang
XX
Buchwald
Stephen L
SL
D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis*; D010720:Phosphines / Q000737:chemistry; D013237:Stereoisomerism
D001643:Bridged Bicyclo Compounds; D006841:Hydrocarbons, Aromatic; D010720:Phosphines