title: HLA class I distribution in Japanese patients with schizophrenia.
abstract: Several Caucasian studies and one Japanese study have observed associations between human leukocyte antigen (HLA) class I specificities, including A24 (9) and A26 (10) and schizophrenia. Most of those studies were conducted in 1970s and early 1980s, when the typing technique of HLA was not adequately reliable. Also, an operational diagnostic system was not employed in many of the studies. The present study investigated frequencies of HLA-A specificities in schizophrenia patients (ICD-10 and DSM-III-R, n=98) and sex-matched healthy controls (n=392) from population in the southwestern part of Japan. HLA-B and -C specificities were studied in addition. Frequencies of subjects possessing A24 and A26 were not different between the patients and controls (54% and 24% in the patients and 62% and 24% in the controls, respectively). No significant difference was found in frequencies of other class I (A, B, and C) specificities between the patients and the controls. Thus, the present study provided no evidence for an association between the HLA class I specificities, including A24, A26, and others, and schizophrenia in the Japanese population.
authors.affiliation: Department of Psychiatry, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Shunji
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
authors.forename: Akira
authors.initials: A
authors.lastname: Imamura
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Matsuo
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Kayashima
authors.forename: Aoi
authors.initials: A
authors.lastname: Hashida
authors.forename: Shinji
authors.initials: S
authors.lastname: Ono
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsujita
authors.forename: Sumitaka
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Yishibumi
authors.initials: Y
authors.lastname: Nakane
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okazaki
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency; D005805:Genes, MHC Class I / Q000235:genetics; D015234:HLA-A Antigens / Q000235:genetics*; D059871:HLA-A24 Antigen; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000235:genetics* / Q000276:immunology
chemical_list: D015234:HLA-A Antigens; C039683:HLA-A*26 antigen; D059871:HLA-A24 Antigen; D015235:HLA-B Antigens; D015236:HLA-C Antigens