title: Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala.
abstract: The behavioral effects of direct injection of the neuropeptide Y (NPY) Y2 receptor agonist C2-NPY into the basolateral nucleus of the amygdala (BLA) was assessed in rats utilizing the social interaction test (SI). C2-NPY decreased SI time in a dose-dependent manner with a significant change observed at a dose of 80 pmol/100 nl. The anxiogenic effects produced by intra-amygdalar C2-NPY injections were reversed with intraperitoneal administration of alprazolam (1 mg/kg), a known anxiolytic. These findings support the hypothesis that Y2 receptors are involved in the regulation of the anxiety response.
authors.affiliation: Indiana University Medical Center, Indianapolis, IN 46202, USA.
authors.forename: Tammy J
authors.initials: TJ
authors.lastname: Sajdyk
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Schober
authors.forename: David L
authors.initials: DL
authors.lastname: Smiley
authors.forename: Donald R
authors.initials: DR
authors.lastname: Gehlert
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D007398:Interpersonal Relations; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017476:Receptors, Neuropeptide Y / Q000819:agonists / Q000502:physiology*
chemical_list: D017476:Receptors, Neuropeptide Y; C095889:neuropeptide Y2 receptor