[An experimental study of anti-angiogenesis with a cartilage-derived inhibitor].
OBJECTIVE
To evaluate the efficacy of a cartilage-derived inhibitor for the treatment of corneal neovascularization in vivo.


METHODS
A cartilage-derived inhibitor (CDI) from bovine scapula was purified to homogeneity. By rabbit corneal neovascularization (CNV) model, the effect of inhibition of CDI under various conditions was determined in corneal micropocket analysis.


RESULTS
The purified CDI could inhibit strongly the growing speed and area of rabbit CNV compared to control (P < 0.001).


CONCLUSIONS
It is demonstrated that CDI is a potent dose-dependent inhibitor of angiogenesis.
Gao
X
X
Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai 200003.
Lou
Y
Y
Xi
S
S
Feng
W
W
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D016510:Corneal Neovascularization / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D011506:Proteins / Q000494:pharmacology*; D011817:Rabbits
D020533:Angiogenesis Inhibitors; D011506:Proteins