title: Effects of physiologic human brain motion on proton spectroscopy: quantitative analysis and correction with cardiac gating.
abstract: Proton MR spectroscopy is a powerful noninvasive method that enables measurement of certain brain metabolites in healthy subjects and patients with diseases. A major difficulty with clinical and research applications of in vivo proton MR spectroscopy is the variability of metabolite concentrations, especially in regions with substantial physiologic motion. In our preliminary evaluation, we tested the hypothesis that physiologic brain motion leads to lower mean metabolite concentrations and higher SDs for the measured metabolite concentrations.
authors.affiliation: Department of Radiology, University of Miami School of Medicine, 1115 NW 14th Street, Miami, FL 33136, USA.
authors.forename: Pradip M
authors.initials: PM
authors.lastname: Pattany
authors.forename: Imad H
authors.initials: IH
authors.lastname: Khamis
authors.forename: Brian C
authors.initials: BC
authors.lastname: Bowen
authors.forename: Karl
authors.initials: K
authors.lastname: Goodkin
authors.forename: R Gregory
authors.initials: RG
authors.lastname: Weaver
authors.forename: James B
authors.initials: JB
authors.lastname: Murdoch
authors.forename: M Judith
authors.initials: MJ
authors.lastname: Donovon Post
authors.forename: Robert M
authors.initials: RM
authors.lastname: Quencer
mesh_terms: D000328:Adult; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009038:Motion; D009206:Myocardium / Q000378:metabolism*; D011446:Prospective Studies