title: A report of 50 patients with carcinoma of the hypopharynx treated by total pharyngolaryngo-oesophagectomy repaired by gastric transposition.
abstract: Extensive carcinoma of the hypopharynx requires aggressive surgery, which can lead to loss of function and a high morbidity and mortality. This paper reports 50 patients with carcinoma of the hypopharynx treated with total pharyngolaryngo-oesophagectomy and gastric transposition. Thirty-two patients had primary surgery and 18 had salvage surgery for recurrence following radiotherapy. Two technical modifications to the standard procedure that have evolved during this period are the use of a diverticuloscope for dissection of the middle third of the oesophagus and the routine insertion of chest drains peroperatively. Complications were relatively unusual in the primary surgery group, but were a problem in those patients undergoing salvage surgery. Stenosis did not tend to occur with gastric transposition repair, but three patients had delayed gastric emptying with prolonged hospital stays. The tumour-specific actuarial survival at 4 years was 39% and the observed survival was 25%. Pharyngolaryngo-oesophagectomy and gastric transposition is becoming safer owing to increased multidisciplinary experience in this form of surgery. Survival is improved with the use of postoperative radiotherapy in patients undergoing primary surgery.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, University of Liverpool, Liverpool, UK. orl@liv.ac.uk
authors.forename: A S
authors.initials: AS
authors.lastname: Jones
authors.forename: C J
authors.initials: CJ
authors.lastname: Webb
authors.forename: J E
authors.initials: JE
authors.lastname: Fenton
authors.forename: J P
authors.initials: JP
authors.lastname: Hughes
authors.forename: D J
authors.initials: DJ
authors.lastname: Husband
authors.forename: J H
authors.initials: JH
authors.lastname: Winstanley
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000601:surgery*; D016629:Esophagectomy; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000401:mortality / Q000601:surgery*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D010611:Pharyngectomy; D011183:Postoperative Complications; D012189:Retrospective Studies; D016879:Salvage Therapy; D013270:Stomach / Q000637:transplantation*; D015996:Survival Rate