DNA analogues: from supramolecular principles to biological properties.
Mainly driven by the needs of antisense research, a large number of oligonucleotide analogues have been prepared and evaluated over the last 15 years. Besides minor structural modifications of the building blocks of DNA and RNA itself, a considerable effort has been devoted to the de novo design of nucleoside analogues with improved binding properties. A particularly successful concept turned out to be that of conformational restriction. This review focuses on recent advances in this area and tries to summarize scope and limitations of this design principle.
Leumann
Christian J
CJ
Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012, Bern, Switzerland. leumann@ioc.unibe.ch
D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D015195:Drug Design; D018716:Molecular Mimicry; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry
D009705:Nucleosides; D009841:Oligonucleotides; D004247:DNA