Relapsing Exophiala jeanselmei phaeohyphomycosis in a lung-transplant patient.
Dematiaceous fungi are a cause of a variety of human infections, including phaeohyphomycosis, that may affect patients with solid organ or bone marrow transplants. Exophiala jeanselmei, the most common cause of the pheomycotic cyst/subcutaneous phaeohyphomycosis in the United States, has been shown to cause disease in transplant recipients. We report a lung-transplant patient with relapsing and invasive E. jeanselmei phaeohyphomycosis, who previously had a pheomycotic cyst excised and treated with oral fluconazole. The patient was subsequently treated with re-excision and an 8-month course of oral itraconazole without relapse as to date.
Chua
J D
JD
Department of Clinical Pathology (Section of Microbiology), Cleveland Clinic Foundation, Ohio 44195, USA.
Gordon
S M
SM
Banbury
J
J
Hall
G S
GS
Procop
G W
GW
D000328:Adult; D003560:Cysts / Q000382:microbiology* / Q000601:surgery*; D003881:Dermatomycoses / Q000188:drug therapy / Q000382:microbiology*; D005093:Exophiala / Q000302:isolation & purification*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
D017964:Itraconazole