Comparison of effects of perflubron and surfactant lung lavage on pulmonary gas exchange in a piglet model of meconium aspiration.
In a piglet model of meconium aspiration we compared lavage with surfactant with that with perflubron (PFOB) and a control group. A human meconium suspension was instilled into piglets which were randomized in 3 (n = 6 each) groups. After lung injury, the control group was ventilated with high-frequency oscillatory ventilation (HFOV) without suctioning and lavage. A second group was lavaged with 10 ml/kg diluted surfactant, a third with 10 ml/kg pre-oxygenated PFOB. Thereafter, the animals of both groups were ventilated with HFOV. After lung injury by instillation of meconium, no further improvement in oxygenation was possible in animals of the control group and 3 piglets died during the ventilation. The subjects of the surfactant group improved promptly, and at the end of the study the arterial pO(2) was significantly better than immediately after injury as compared with the other groups. Lavage with PFOB had intermediate effects in gas exchange and oxygenation compared to surfactant lavage. No differences were observed in arterial blood pressure and heart rate as well as in histological lung injury score between all groups. Lavage with exogenous surfactant as well as with PFOB improve pulmonary gas exchange in a piglet model of meconium aspiration.
Schlösser
Rolf L
RL
Department of Pediatrics, Johann-Wolfgang-Goethe University Hospital, Frankfurt/Main, Germany. rschloesser@zki.uni-frankfurt.de
Veldman
Alex
A
Fischer
Doris
D
Funk
Benjamin
B
Brand
Jörg
J
von Loewenich
Volker
V
D000818:Animals; D000831:Animals, Newborn; D018893:Bronchoalveolar Lavage; D004195:Disease Models, Animal; D005466:Fluorocarbons / Q000494:pharmacology*; D006612:High-Frequency Ventilation; D006651:Histocytochemistry; D006801:Humans; D006842:Hydrocarbons, Brominated; D007231:Infant, Newborn; D008471:Meconium Aspiration Syndrome / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D011897:Random Allocation; D018709:Statistics, Nonparametric; D013501:Surface-Active Agents / Q000494:pharmacology*; D013552:Swine; D013553:Swine Diseases / Q000473:pathology / Q000628:therapy*
D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D013501:Surface-Active Agents; C003072:perflubron