title: High rate of recanalization of middle cerebral artery occlusion during 2-MHz transcranial color-coded Doppler continuous monitoring without thrombolytic drug.
abstract: OBJECTIVE
  Experimental evidence indicates that ultrasound can accelerate thrombolysis. We report our findings on early recanalization during transcranial color-coded Doppler (TCCD) continuous monitoring in acute stroke patients with middle cerebral artery (MCA) main stem occlusion.
  
  
  METHODS
  We performed continuous TCCD monitorings in 6 consecutive patients with acute MCA main stem occlusion using a 2-MHz transducer. Patients were not treated with recombinant tissue plasminogen activator.
  
  
  RESULTS
  Partial recanalization, defined as blunted waveforms, occurred during monitoring in 5 patients (83%). The mean time to beginning of recanalization was 17.2+/-9.6 minutes. Complete recanalization at 24 hours occurred in only 1 patient. The mean National Institutes of Health Stroke Scale score in the patients who recanalized during monitoring was 21.2+/-4.1 at baseline, 19.2+/-5 at 2 hours, and 15.6+/-3.4 at 24 hours (P=0.1).
  
  
  CONCLUSIONS
  In this short series of patients with acute MCA main stem occlusion, not treated with recombinant tissue plasminogen activator, we found a high rate of early partial recanalization during continuous exposure to 2-MHz ultrasound.
authors.affiliation: Department of Neurology, University of Toulouse, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Cintas
authors.forename: Anne Pavy
authors.initials: AP
authors.lastname: Le Traon
authors.forename: Vincent
authors.initials: V
authors.lastname: Larrue
mesh_terms: D001241:Aspirin / Q000627:therapeutic use; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D015424:Reperfusion; D018401:Sample Size; D012720:Severity of Illness Index; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D001241:Aspirin