Fortum stability in different disposable infusion devices by pyridine assay.
The stability of ceftazidime in 5% dextrose injection and 0.9% sodium chloride injection when stored in a different disposable infusion device was determined. Solutions of ceftazidime 40 mg/ml were used to fill the drug administration devices. Stability was determined for both 5% dextrose injection and 0.9% sodium chloride injection solutions at 37 degrees C in four disposable infusion devices. Ceftazidime and its mean degradation product, pyridine, were simultaneously assayed in triplicate by a stability-indicating high-performance liquid chromatographic (HPLC) method. This method was simple, sensitive (limit of quantitation (LOQ), 2 ng injected for both compounds), rapid (run time was 7 min) and precise (mean recovery was 100.5+/-2.9 and 103.6+/-1.9% for pyridine and ceftazidime, respectively). The ceftazidime stability in the 5% dextrose solution was lower than in the 0.9% sodium chloride solution. When stored at 37 degrees C in a disposable infusion device, the stability of the ceftazidime is included in large hourly range, depending strongly on the manufacturer. The stability of ceftazidime exceed 19 h in none studied cases. The pyridine formed in 24 h was in the range of 100-400 mg depending on devices and infusions.
Favetta
P
P
Service de Pharmacie, Centre Hospitalier Lyon-Sud, 165 Chemin du Grand Revoyet, Pierre Bénite, France. patfavetta@hotmail.com
Allombert
C
C
Breysse
C
C
Dufresne
C
C
Guitton
J
J
Bureau
J
J
D002442:Ceftazidime / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry*; D002511:Cephalosporins / Q000008:administration & dosage*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D007260:Infusion Pumps; D011725:Pyridines / Q000032:analysis*
D002511:Cephalosporins; D011725:Pyridines; D002442:Ceftazidime; C023666:pyridine