title: Sevoflurane vs. isoflurane: a clinical comparison in day surgery.
abstract: Discharge times after ambulatory surgery are determined by postoperative complications and in particular by the presence and severity of nausea and vomiting. Sevoflurane has become a popular agent for day-case surgery despite little evidence of clear advantages over current alternatives. We compared this agent with isoflurane in day-case patients undergoing knee arthroscopy in order to quantify the incidence of complications associated with each agent. One hundred and eighty patients received a standardised anaesthetic induction with propofol and fentanyl followed by maintenance with either isoflurane or sevoflurane. Standardised postoperative analgesic and anti-emetic drugs were prescribed. Any intra-operative cardiovascular or respiratory instability was recorded. After surgery, nausea, vomiting and pain were assessed. Almost all patients made an uneventful recovery and were discharged as scheduled. There was a significantly higher incidence of complications in the sevoflurane group. These included the presence of nausea and vomiting, and cardiovascular and respiratory complications. We found nothing to commend the routine use of sevoflurane rather than isoflurane in the context of day case anaesthesia.
authors.affiliation: Department of Anaesthesia, Poole General Hospital, Poole BH15 2JB, UK.
authors.forename: D H
authors.initials: DH
authors.lastname: Elcock
authors.forename: B P
authors.initials: BP
authors.lastname: Sweeney
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000556:Ambulatory Surgical Procedures; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D000932:Antiemetics / Q000627:therapeutic use; D001182:Arthroscopy; D002318:Cardiovascular Diseases / Q000139:chemically induced; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects*; D007719:Knee Joint / Q000601:surgery; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects*; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control; D020250:Postoperative Nausea and Vomiting / Q000139:chemically induced* / Q000188:drug therapy; D012120:Respiration Disorders / Q000139:chemically induced; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D000932:Antiemetics; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane