[Expression of ICAM-1/LFA-1 in the pocket area of adult periodontitis].
OBJECTIVE
To study the expression of ICAM-1/LFA-1 in the pocket area of adult periodontitis.


METHODS
Expressions of ICAM-1/LFA-1 in adult gingival of periodontitis and healthy subjects were studied by alkaline phosphorylase-antialkaline phosphorylase technique.


RESULTS
Junctional epithelium and apical part of sulcus epithelium expressed ICAM-1 in both adult periodontitis and healthy gingiva, showing an ICAM-1 gradient change with maximal staining at tooth aspect and weaker staining in the basal layer of keratinocytes. Significantly more LFA-1 positive leukocytes were observed in connective tissues and within pocket epithelium in adult periodontitis than those in healthy gingiva.


CONCLUSIONS
ICAM-1/LFA-1 may provide important adhesion pathway for leukocytes migration into gingiva sulcus in adult periodontitis lesions.
Yan
P
P
College of Stomatology, Hubei Medical University, Wuhan 430079.
Yue
J
J
Jiang
H
H
D000328:Adult; D005260:Female; D005881:Gingiva / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D010514:Periodontal Pocket / Q000378:metabolism / Q000473:pathology*; D010518:Periodontitis / Q000378:metabolism / Q000473:pathology*
D016169:Lymphocyte Function-Associated Antigen-1; D018799:Intercellular Adhesion Molecule-1