Severe liver damage with leflunomide.
Potentially life-threatening; close monitoring required.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007555:Isoxazoles / Q000009:adverse effects* / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000139:chemically induced*; D017093:Liver Failure / Q000139:chemically induced*
D007166:Immunosuppressive Agents; D007555:Isoxazoles