[Changes in bladder compliance and detrusor contraction/relaxation of diabetic rats].
OBJECTIVE
To provide experimental basis for further study on the mechanism of diabetic cystopathy (DCP).


METHODS
The bladder compliance and contraction/relaxation of whole bladder/detrusor strips were evaluated in vitro on diabetic rats.


RESULTS
Significant decrease of detrusor contraction/relaxation and increase of bladder compliance were observed (P < 0.01). The contractile force of diabetes, diuresis and control were (20.80 +/- 6.38), (31.66 +/- 6.17) and (40.10 +/- 7.21) g/100 mg T respectively.


CONCLUSIONS
The results suggest that both the injury of detrusor contraction/relaxation and bladder compliance are important factors for diabetic cystopathy, however, diuresis does not play a major role in the development of DCP.
Gong
Y
Y
Urological Center, Southwesten Hospital, Third Millitary Medical University. Chongqing 400038, China.
Song
B
B
Jin
X
X
Xiong
E
E
D000818:Animals; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D009126:Muscle Relaxation; D051381:Rats; D017208:Rats, Wistar; D001743:Urinary Bladder / Q000503:physiopathology*; D001745:Urinary Bladder Diseases / Q000503:physiopathology*