title: Roles of pancreatic polypeptide in regulation of food intake.
abstract: Pancreatic polypeptide (PP) is produced in pancreatic islets of Langerhans and released into the circulation after ingestion of a meal. Peripherally administered PP suppresses food intake and gastric emptying. On the other hand, central administration of PP elicits food intake and gastric emptying. Therefore, PP actions on food intake may be, in part, attributable to gastric emptying. PP transgenic mice exhibit decreases in both food intake and gastric emptying rate that were clearly reversed by anti-PP antiserum. PP is an anorexigenic signal in the periphery and an orexigenic signal in the central nervous system.
authors.affiliation: Aburahi Laboratories, Shionogi & Co. Ltd., Shiga, 520-3423 Japan.
authors.forename: Goro
authors.initials: G
authors.lastname: Katsuura
authors.forename: Akihiro
authors.initials: A
authors.lastname: Asakawa
authors.forename: Akio
authors.initials: A
authors.lastname: Inui
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects; D005746:Gastric Emptying / Q000187:drug effects*; D051379:Mice; D008822:Mice, Transgenic; D010191:Pancreatic Polypeptide / Q000378:metabolism* / Q000502:physiology*; D013997:Time Factors
chemical_list: D010191:Pancreatic Polypeptide