title: BAL 9141, a new broad-spectrum pyrrolidinone cephalosporin: activity against clinically significant anaerobes in comparison with 10 other antimicrobials.
abstract: The in vitro potency of BAL 9141, a new pyrrolidinone cephalosporin, was tested against non-duplicate strains of anaerobic bacteria. The MIC(50) was 1 mg/L against Actinomyces species, Clostridium species, Gram-positive anaerobic cocci, Porphyromonas species, Fusobacterium species, Lactobacillus species, Prevotella species and Veillonella species. The MIC(50) was 16 mg/L for Bacteroides fragilis and other Bacteroides species. BAL 9141 was not active against cefoxitin-resistant Bacteroides fragilis.
authors.affiliation: Bristol Centre for Antimicrobial Research and Evaluation, North Bristol NHS Trust/University of Bristol, Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK.
authors.forename: M
authors.initials: M
authors.lastname: Wootton
authors.forename: K E
authors.initials: KE
authors.lastname: Bowker
authors.forename: H A
authors.initials: HA
authors.lastname: Holt
authors.forename: A P
authors.initials: AP
authors.lastname: MacGowan
mesh_terms: D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000302:isolation & purification; D002511:Cephalosporins / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D007769:Lactams / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology*; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D002511:Cephalosporins; D007769:Lactams; D010406:Penicillins; D013845:Thienamycins; C443755:ceftobiprole