[Chromosome t (8; 21) and t (15; 17) in a patient with acute myeloid leukemia].
OBJECTIVE
To report an acute myeloid leukemia (AML) patient with both chromosome t (8; 21) and t (15; 17).


METHODS
Chromosome specimen was prepared by short-term culture of bone marrow cells, karyotype analyses by R-banding technique, and fusion genes by reverse transcriptase-polymerase chain reaction (RT-PCR).


RESULTS
Karyotype analyses showed the appearance of 45, X, -X, t (8; 21), t (15; 17), and RT-PCR assay revealed AML1/ETO and PML-RARalpha fusion gene transcripts.


CONCLUSIONS
AML with both t (8; 21) and t (15; 17) might be recognized as a a novel subtype of acute leukemias.
Gao
Y
Y
Shanghai First People Hospital, Shanghai 200080, China.
Wang
C
C
Xu
L
L
Cao
Q
Q
Zhu
Y
Y
Cai
Q
Q
Yan
S
S
Yang
X
X
D001854:Bone Marrow Cells / Q000166:cytology; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D014178:Translocation, Genetic; D055815:Young Adult