title: Relapses after treatment of external genital warts are more frequent in HIV-positive patients than in HIV-negative controls.
abstract: BACKGROUND
  Recurrences of cervical lesions associated with human papillomavirus are more frequent in HIV-infected (HIV+) than in HIV- women. Recurrences of external genital warts were investigated in HIV+ patients and HIV- control subjects.
  
  
  OBJECTIVE
  To compare relapses after treatment of external genital warts between HIV+ and HIV- patients.
  
  
  METHODS
  At the sexually transmitted disease (STD) center in Brescia, Italy, 1336 patients (241 HIV+ and 1095 HIV-) with external genital warts were examined in the decade 1990 to 1999. Various local treatments were used.
  
  
  RESULTS
  Treatments generally triggered recovery from the lesions. The relapses observed up to 1 year after the response, examined by survival analysis, were significantly (P < 0.001) more frequent in the HIV+ (160 cases; 66.4%) than in the HIV- (294 cases; 26.8%) subjects. Multiple relapses observed up to 1 year after treatment occurred in 69 of 241 HIV+ patients, as compared with 14 of 1095 HIV- control subjects (P < 0.001).
  
  
  CONCLUSIONS
  According to the study findings, HIV infection can be considered a risk factor for the development and recurrence of external genital warts. Multiple relapses should drive patients to HIV testing.
authors.affiliation: Department of Dermatology, Brescia Hospital, Brescia, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Panfilis
authors.forename: Giulia
authors.initials: G
authors.lastname: Melzani
authors.forename: Giovanni
authors.initials: G
authors.lastname: Mori
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ghidini
authors.forename: Severo
authors.initials: S
authors.lastname: Graifemberghi
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology* / Q000628:therapy; D000328:Adult; D016022:Case-Control Studies; D003218:Condylomata Acuminata / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors