title: [Inflammatory markers after laparoscopy versus laparotomy cholecystectomy].
abstract: OBJECTIVE
  The study is carried out to determine whether the level of IL-6 is altered and in what way after surgery as well as if such a change could be an indicator of increased morbidity after surgical treatment. MATERIALS OF THE STUDY: Chemiluminesence immunoeassay system was used in order to establish IL-6 level in blood samples of 71 patients that underwent abdominal surgery, 36 Laparoscopic Cholecystectomy (LC) and 35 Open Cholecystectomy (OC) at time 0 (before the operation), 1 h, 2 h, 3 h, 6 h, 24 h and 48 h after the operation.
  
  
  RESULTS
  Plasma IL-6 levels are significantly increased after OC; we observed 3 cases of post-operative infections, in which IL-6 returned to normal levels 6 days after surgery. Analogous variation to the IL-6 levels was noted for the C-reactive protein levels.
  
  
  CONCLUSIONS
  Laparoscopic cholecystectomy, a so called mini-invasive surgical procedure, is associated to a small increase of IL-6 serum levels and provides better post-operative conditions to the patients by reducing surgical stress and the infectious complications correlated to the surgical procedure.
  
  
  CONCLUSIONS
  During OC there is a significant higher elevation of IL-6 serum levels than after laparoscopic cholecystectomy. Variation of C-reactive protein serum levels after surgery is analogous to variation of IL-6 levels.
authors.affiliation: Facoltà di Medicina e Chirurgia Dipartimento di Scienze Chirurgiche Divisione di Chirurgia Geriatrica, Università degli Studi di L'Aquila.
authors.forename: M
authors.initials: M
authors.lastname: Schietroma
authors.forename: M
authors.initials: M
authors.lastname: Rossi
authors.forename: F
authors.initials: F
authors.lastname: Fraioli
authors.forename: C
authors.initials: C
authors.lastname: Liakos
authors.forename: A
authors.initials: A
authors.lastname: Carloni
authors.forename: S
authors.initials: S
authors.lastname: Mattucci
authors.forename: F
authors.initials: F
authors.lastname: Carlei
authors.forename: M A
authors.initials: MA
authors.lastname: Pistoia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002763:Cholecystectomy / Q000379:methods; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D007813:Laparotomy; D008297:Male; D008875:Middle Aged
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6