title: Metalation of 2-chloromethyl-2-oxazolines: synthesis of 1,2,3-tris(oxazolinyl)cyclopropanes and derivatives.
abstract: 2-Chloromethyl-2-oxazoline converts cleanly into trans-1,2,3-tris(oxazolinyl)cyclopropane upon treatment with strong bases such as LDA or KN(SiMe(3))(2). Deprotonation of the above cyclopropane followed by the addition of electrophiles allows the preparation of more functionalized tris(oxazolinyl)cyclopropanes.
authors.affiliation: Centro C.N.R. M.I.S.O., Dipartimento Farmaco-Chimico, Università di Bari, Via E. Orabona 4, I-70125 Bari, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Capriati
authors.forename: Saverio
authors.initials: S
authors.lastname: Florio
authors.forename: Renzo
authors.initials: R
authors.lastname: Luisi
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Rocchetti