Transport to the photoreceptor outer segment by myosin VIIa and kinesin II.
This paper reviews our studies in which we have used mutant mice to investigate the roles of myosin VIIa and kinesin II in the transport of proteins to the photoreceptor outer segment. These studies suggest that both motors participate in moving opsin along the connecting cilium. Given the velocities measured for these motors in vitro, it is predicted that the resulting concentration of opsin in the plasma membrane of the connecting cilium is surprisingly low.
Williams
David S
DS
Department of Pharmacology, University of California, School of Medicine, Mail Code 0983, 9500 Gilman Drive, La Jolla, CA 92093-0983, USA. dswilliams@ucsd.edu
D000818:Animals; D001692:Biological Transport; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002462:Cell Membrane / Q000378:metabolism; D004398:Dyneins; D016547:Kinesins; D051379:Mice; D018345:Mice, Knockout; D008818:Mice, Neurologic Mutants; D020409:Molecular Motor Proteins; D009124:Muscle Proteins / Q000235:genetics*; D000081412:Myosin VIIa; D009218:Myosins / Q000235:genetics*; D012374:Rod Cell Outer Segment / Q000378:metabolism*; D017299:Rod Opsins / Q000378:metabolism*
D002135:Calcium-Binding Proteins; D020409:Molecular Motor Proteins; D009124:Muscle Proteins; C000631456:Myo7a protein, mouse; D000081412:Myosin VIIa; D017299:Rod Opsins; C074152:kinesin-II; D009218:Myosins; D004398:Dyneins; D016547:Kinesins