[The change in hyaluronic acid (HA) in auto-and allo-skin intermingled grafting in extensive full thickness burn in rat model].
OBJECTIVE
To elucidate the changes in hyaluronic acid (HA) contents in auto-and alloskin intermingled grafting.


METHODS
HA was determined by radio-immunoassay in auto-and alloskin intermingled grafting (a large sheet of allograft inlaid with small stamps of autoskin) in experimental extensive full-thickness burn rats on 3rd, 5th, 7th, 14th, 21st, 28th postoperation days.


RESULTS
In both areas of intermingled skin grafting, the contents of HA was reduced first and increased significantly thereafter, but the contents in auto-skin areas rose earlier and higher than those in allo-ones.


CONCLUSIONS
The results suggest that adequate application of HA may be beneficial to the healing and remodelling of grafted area.
Ding
R
R
Shanghai Burn Institute, Rui Jin Hospital, Shanghai Second Medical University, Shanghai 200025, China.
Zhao
Y
Y
Wang
L
L
D000818:Animals; D002056:Burns / Q000378:metabolism / Q000601:surgery*; D006820:Hyaluronic Acid / Q000032:analysis*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000737:chemistry*; D016038:Skin Transplantation; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
D006820:Hyaluronic Acid