[Clinical and cytogenetic analysis of patients with lymphoid malignancies carrying 14q32 abnormality].
OBJECTIVE
To investigate the clinical and cytogenetic characteristics of patients with lymphoid malignancies (LM) harboring 14q32 abnormalities.


METHODS
The cases with 14q32 aberrations in 225 patients with various LM were analyzed by clinical data.


RESULTS
Fifteen (6.67%) patients with abnormalities involving 14q32 were found and the pattern of 14q32 aberration was associated with different types of LM. t(8;14)(q24;q32) was the commonest karyotypic aberration and predominant in acute leukemias. There was no consistent profile morphologically and immunophenotypically in the involving leukemias, however there were common clinical and prognostic features and often with an additional characteristic abnormality of ins(1;6)(q11;q23q27). One case of myelodysplasia (MDS) secondary to multiple myeloma displayed t(7;14)(q34;q32) in primary clone and additional 7q- and 20q- in derivative clone that was frequently involved in MDS.


CONCLUSIONS
14q32 abnormalities and additional chromosomal alterations can facilitate the diagnosis and prognostic assessment for the involving LMs.
Liu
S
S
Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
Qin
S
S
Wang
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007938:Leukemia / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009436:Neural Tube Defects / Q000235:genetics; D011379:Prognosis; D014178:Translocation, Genetic