[The inhibitory effect of CLA on mice forestomach neoplasia induced by B(a)P].
OBJECTIVE
To study the inhibitory effect of CLA on the postinitiation phase of forestomach neoplasia formation induced by B(a)P and explore its possible mechanism of anticarcinogenesis.


METHODS
Kunming mice were divided into five groups, i.e. salad oil control group, CLA control group, B(a)P group, B(a)P + high dose CLA group and B(a)P + low dose CLA group. The experimental period was 23 weeks, and the endpoints included cell proliferation, expression of Pan-ras P21 and some enzymes.


RESULTS
Short term CLA treated significantly inhibited the forestomach neoplasia formation induced by B(a)P at postinitiation phase. The incidence of tumor in the groups of B(a)P, B(a)P + high dose CLA and B(a)P + low dose CLA was 100%, 60% and 69% respectively (P < 0.05). The possible mechanism of this anticarcinogenic effect may be related to the inhibition of cell proliferation and the induction of the activities of GSH-Px, GST and SOD, irrespective of the regulation of expression of Pan-ras P21.


CONCLUSIONS
CLA is a promising chemopreventive agent, and its anticarcinogenic effect may involve its effects on the redox system.
Zhu
Y
Y
Public Health College, Harbin Medical University, Haerbin 150001, China.
Qiou
J
J
Chen
B
B
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001564:Benzo(a)pyrene / Q000633:toxicity*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D019787:Linoleic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000201:enzymology; D051379:Mice; D015689:Oncogene Protein p21(ras) / Q000032:analysis; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000097:blood
D016588:Anticarcinogenic Agents; D001564:Benzo(a)pyrene; D019787:Linoleic Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D015689:Oncogene Protein p21(ras)