Second allogeneic hematopoietic stem cell transplantation in hematologic malignancies in children: long-term results of a multicenter study of the Spanish Working Party for Bone Marrow Transplantation in Children (GETMON).
Twenty-four children with acute leukemia (21) or chronic myeloid leukemia (3) who relapsed after a first hematopoietic stem cell transplantation (HSCT) underwent a second allogeneic HSCT. Sixteen patients died from relapse or transplant related causes and 8 are alive and disease-free with a probability of event-free survival at 5 years of 32%. These results show that this procedure offers a chance to a subset of these patients.
Muñoz
Arturo
A
Badell
Isabel
I
Olivé
Teresa
T
Verdeguer
Amparo
A
Gómez
Pedro
P
Bureo
Encarna
E
D000293:Adolescent; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000401:mortality*; D006801:Humans; D007938:Leukemia / Q000401:mortality / Q000628:therapy*; D008297:Male; D012008:Recurrence; D013030:Spain / Q000453:epidemiology; D015996:Survival Rate; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000276:immunology / Q000401:mortality