title: Antigen-dependent B-cell development.
abstract: There is growing evidence that the development of naïve B cells depends on the interaction of self antigens with the BCR. A view that has emerged over the past year is that BCR signal output contributes in a large part to the developmental fate of peripheral B cells. Differences in antigen-receptor signal strength may determine whether B cells assume a marginal zone, follicular or B-1 phenotype.
authors.affiliation: Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.
authors.forename: Annaiah
authors.initials: A
authors.lastname: Cariappa
authors.forename: Shiv
authors.initials: S
authors.lastname: Pillai
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000502:physiology*; D001402:B-Lymphocytes / Q000502:physiology*; D001853:Bone Marrow / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology*; D006801:Humans; D013154:Spleen / Q000502:physiology
chemical_list: D001324:Autoantigens