title: The value of switching from cyclosporine to tacrolimus in the treatment of refractory acute rejection and obliterative bronchiolitis after lung transplantation.
abstract: Standard cyclosporine-based immunosuppression is ineffective in the treatment of refractory acute rejection (RAR) and obliterative bronchiolitis (OB) that follows lung transplantation. The aim of this study was to evaluate the results of switching from cyclosporine to tacrolimus in the treatment of these situations. Nineteen patients entered the study. The indication for switching was OB in 11 patients and RAR in 8. Mean age was 41.3 +/- 13.1 years. In patients with RAR, the number of acute rejections was 1.5 +/- 0.7 and there were zero episodes per patient per 100 days before and after switching, respectively ( P = 0.02). There was no significant reduction of the decline of forced expiratory volume (FEV(1)) within 6 months after switching in patients with OB. We conclude that the conversion from cyclosporine to tacrolimus was associated with favourable results in the treatment of RAR. Further studies are required to assess the influence of this approach in the treatment of OB.
authors.affiliation: Department of Cardiothoracic Surgery, University of Vienna, Währinger Gürtel 18-20, 1090, Austria.
authors.forename: Kambiz
authors.initials: K
authors.lastname: Sarahrudi
authors.forename: Angelo
authors.initials: A
authors.lastname: Carretta
authors.forename: Wilfried
authors.initials: W
authors.lastname: Wisser
authors.forename: Omer
authors.initials: O
authors.lastname: Senbaklavaci
authors.forename: Meinhard
authors.initials: M
authors.lastname: Ploner
authors.forename: Petra
authors.initials: P
authors.lastname: Neuhauser
authors.forename: Michael
authors.initials: M
authors.lastname: Dobrovits
authors.forename: Gabriel
authors.initials: G
authors.lastname: Miwai Marta
authors.forename: Andras
authors.initials: A
authors.lastname: Papp
authors.forename: Walter
authors.initials: W
authors.lastname: Klepetko
mesh_terms: D000208:Acute Disease; D000328:Adult; D001989:Bronchiolitis Obliterans / Q000188:drug therapy*; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D016559:Tacrolimus / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus