[Histological grading in ductal carcinoma in situ of the breast].
OBJECTIVE
To study the significance of histological grading as a prognostic factor in ductal carcinoma in situ of the breast.


METHODS
According to Van Nuy's classification, 32 cases of ductal carcinoma in situ (DCIS) of the breast were divided into three grades.


RESULTS
Low grade (well differentiated, low grade DCIS) 12 patients (37.5%); Intermediate grade, 9 patients (28.1%); High grade (poorly differentiated DCIS) 11 patients (34.4%). Among the high grade DCIS, the histological subtypes were comedo (9 patients), micto papillary (1 patient) and solid (1 patient). The positive expression of c-erbB-2, p53 and MIB-1 in high grade DCIS was higher than that in intermediate and low grade DCIS. The difference between high grade and low grade DCIS was significant (P < 0.05). The expression of ER in high grade DCIS was lower than that in intermediate and low grade DCIS.


CONCLUSIONS
Histological grading of breast ductal carcinoma in situ may be a good prognostic factor.
Xu
W
W
Department of Pathology, Cancer Hospital, Shanghai Medical University, Shanghai 200032.
Zhu
X
X
Zhang
T
T
Tu
X
X
Shi
D
D
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D012720:Severity of Illness Index; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D016159:Tumor Suppressor Protein p53