title: Oxygen consumption after hypothermic cardiopulmonary bypass: the effect of continuing a propofol infusion postoperatively.
abstract: OBJECTIVE
  To evaluate the effect of a fixed rate of infusion of propofol on total body oxygen consumption during the postoperative rewarming phase after cardiopulmonary bypass.
  
  
  METHODS
  Prospective, randomized, controlled study.
  
  
  METHODS
  Cardiac intensive care unit, university hospital.
  
  
  METHODS
  Twenty-four male and female patients undergoing elective first-time coronary artery bypass graft surgery.
  
  
  METHODS
  Total body oxygen consumption was measured using a pulmonary artery catheter and thermodilution during postoperative rewarming. Twelve patients had propofol infused at 2 mg/kg/h for 4 hours or until rewarmed.
  
  
  RESULTS
  Total body oxygen consumption was reduced in the propofol group compared with the control group. Oxygen consumption was a median of 30.0 mL/min/m(2) less in the patients receiving propofol (p = 0.01). One patient receiving propofol shivered compared with 4 in the control group (p = 0.14).
  
  
  CONCLUSIONS
  Administration of propofol during postoperative rewarming reduces total body oxygen consumption and may reduce shivering.
authors.affiliation: Department of Anaesthesia, Glasgow Royal Infirmary, Glasgow, United Kingdom. smilne@umich.edu
authors.forename: Stewart E
authors.initials: SE
authors.lastname: Milne
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: James
authors.forename: Susan
authors.initials: S
authors.lastname: Nimmo
authors.forename: Stephen
authors.initials: S
authors.lastname: Hickey
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*; D011182:Postoperative Care; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology; D011446:Prospective Studies; D017694:Rewarming / Q000379:methods; D013815:Thermodilution
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol