title: Reaction of rat connective tissue to implanted dentin tubes filled with a white mineral trioxide aggregate.
abstract: The purpose of this paper was to study the reaction of rat subcutaneous connective tissue to the implantation of dentin tubes filled with white mineral trioxide aggregate (MTA), a material that will be marketed. The tubes were implanted into rat subcutaneous tissue and the animals were sacrificed after 7 and 30 days. The undecalcified pieces were prepared for histological analysis with polarized light and von Kossa technique for mineralized tissues. Granulations birefringent to polarized light and an irregular structure like a bridge were observed next to the material; both were von Kossa positive. Also, in the dentin wall tubules a layer of birefringent granulations was observed. The results were similar to those reported for gray MTA, indicating that the mechanisms of action of the white and gray MTA are similar.
authors.affiliation: Department of Restorative Dentistry, Faculty of Dentistry of Araçatuba, UNESP, Araçatuba, SP, Brazil. rholland@foa.unesp.br
authors.forename: Roberto
authors.initials: R
authors.lastname: Holland
authors.forename: Valdir de
authors.initials: Vd
authors.lastname: Souza
authors.forename: Mauro Juvenal
authors.initials: MJ
authors.lastname: Nery
authors.forename: Italo Medeiros
authors.initials: IM
authors.lastname: Faraco Júnior
authors.forename: Pedro Felício Estrada
authors.initials: PF
authors.lastname: Bernabé
authors.forename: José Arlindo
authors.initials: JA
authors.lastname: Otoboni Filho
authors.forename: Eloi
authors.initials: E
authors.lastname: Dezan Júnior
mesh_terms: D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D001718:Birefringence; D017610:Calcium Compounds / Q000494:pharmacology*; D003238:Connective Tissue / Q000187:drug effects*; D003809:Dentin, Secondary / Q000139:chemically induced; D004338:Drug Combinations; D004343:Drug Implants; D006801:Humans; D010087:Oxides / Q000494:pharmacology*; D051381:Rats; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D017640:Silicates / Q000494:pharmacology*
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D004343:Drug Implants; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate