Dynamic ventilation (3)He-magnetic resonance imaging with lung motion correction: gas flow distribution analysis.
OBJECTIVE
Software was developed to correct for lung motion to improve the description of hyperpolarized (3)He gas distribution in the lung.


METHODS
Five volunteers were studied by dynamic ventilation (3)He-MRI using an ultrafast FLASH 2D sequence with a temporal resolution of 128 milliseconds. Signal kinetics were evaluated in the trachea and seven parenchymal Regions of Interest. Reference ranges for healthy subjects were defined for motion-corrected and uncorrected images.


RESULTS
Motion correction was successfully performed. Reference ranges were 0.11-1.21 seconds for tracheal transit time, 0-0.02 seconds for trachea-alveolar interval, 0.22-0.62 seconds for alveolar rise time and 0-76.6 arbitrary units for alveolar amplitude for motion corrected images, and 0-1.09 seconds, 0-0.11 seconds, 0.26-0.85 seconds, 46.4-99.8 arbitrary units for uncorrected images.


CONCLUSIONS
Evaluation of (3)He-distribution in the lung using motion correction of dynamic (3)He-ventilation imaging is feasible and gives more narrow reference ranges.
Gast
Klaus Kurt
KK
Department of Radiology, Klinikum Universitaet Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany. kgast@radiologie.klinik.uni-mainz.de
Puderbach
Michael Ulrich
MU
Rodriguez
Ignacio
I
Eberle
Balthasar
B
Markstaller
Klaus
K
Hanke
Alexander Thomas
AT
Schmiedeskamp
Joerg
J
Weiler
Norbert
N
Lill
Jana
J
Schreiber
Wolfgang G
WG
Thelen
Manfred
M
Kauczor
Hans-Ulrich
HU
D000328:Adult; D005260:Female; D006371:Helium; D006801:Humans; D007554:Isotopes; D008168:Lung / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D012123:Pulmonary Ventilation / Q000502:physiology*; D015656:Respiratory Mechanics; D012984:Software; D013997:Time Factors
D007554:Isotopes; D006371:Helium