title: Identification of indolyl-3-acryloylglycine in the urine of people with autism.
abstract: HPLC analysis of the urine of autistic subjects indicated the presence of an unidentified component in greatly increased concentrations. We have reported the isolation of this component by HPLC and its identification. Mass spectrometry, NMR and UV spectroscopy identified the peak as corresponding to indolyl-3-acryloylglycine (IAG, 3), and this has been confirmed by an independent synthesis.
authors.affiliation: Institute of Pharmacy, Chemistry and Biomedical Sciences, University of Sunderland, UK. roz.anderson@sunderland.ac.uk
authors.forename: Rosaleen J
authors.initials: RJ
authors.lastname: Anderson
authors.forename: David J
authors.initials: DJ
authors.lastname: Bendell
authors.forename: Ian
authors.initials: I
authors.lastname: Garnett
authors.forename: Paul W
authors.initials: PW
authors.lastname: Groundwater
authors.forename: W John
authors.initials: WJ
authors.lastname: Lough
authors.forename: Malcolm J
authors.initials: MJ
authors.lastname: Mills
authors.forename: Dawn
authors.initials: D
authors.lastname: Savery
authors.forename: Paul E G
authors.initials: PE
authors.lastname: Shattock
mesh_terms: D001321:Autistic Disorder / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D005998:Glycine / Q000031:analogs & derivatives* / Q000652:urine*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: C001807:indolylacryloylglycine; D005998:Glycine