The protective effect of dl-tetrahydropalmatine against the development of amygdala kindling seizures in rats.
The influence of dl-tetrahydropalmatine (THP), an active component isolated from a Chinese herbal medicine corydalis, was tested on the development of electrically kindled amygdala. The seizure activity was quantified by a ultrasonic system for vertical motion measurements. Intraperitoneal injection of THP (20 or 30 mg kg(-1)) 30 min before applying the daily kindling stimulus prevented the development of the kindling process. The behavioral seizure score and the motion responses which normally develop during electrical kindling were reduced below their initial values. The results suggest that THP is a very effective antiepileptogenic and anticonvulsant agent when applied to electrically kindled rats.
Lin
Mao-Tsun
MT
Department of Medical Research, Chi-Mei Medical Center, Yung-Kang City, Tainan Hsien 710, Taiwan. mtlin@ym.edu.tw
Wang
Jhi-Joung
JJ
Young
Ming-Shing
MS
D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001600:Berberine Alkaloids / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004582:Electronics, Medical / Q000295:instrumentation / Q000379:methods; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D000927:Anticonvulsants; D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D018377:Neurotransmitter Agents; C014215:tetrahydropalmatine