[Pharmacological aspects in the development of liposomal medicinal preparations for the internal injection of hydrophobic cytostatics].
To improve the action and selectivity of new drugs on tumor cells and the use of currently available pharmaceutical technologies to develop the systems of controlled transport of well-known antitumor compounds is one of the ways of enhancing the efficiency of drug therapy for tumors. The tropicity of steroid hormones to definite organs and tissues makes it possible to use them as specific messengers of alkylating groups to target tissues and tumors. Hormone cytostatics synthesized by this principle have a double mechanism of hormonal and cytotoxic actions. The original Russian water-insoluble hormone cytostatistics testifenon, kortifen, and cytestrol acetate demonstrated local tissue irritation together with high antitumor activity. No rational dosage forms make it possible to conduct clinical trials by parenteral administration. The aim of this paper is to summarize the authors' results of designing hydrophobic antitumor hormone cytostatics. The advantages and disadvantages of different approaches to designing traditional dosage forms and to applying colloid liposomal systems for intravenous administration of water-insoluble agents are shown.
Oborotova
N A
NA
Smirnova
Z S
ZS
Polozkova
Z S
ZS
Baryshnikov
A Iu
AIu
D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000494:pharmacology*; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage* / Q000494:pharmacology*; D014408:Biomarkers, Tumor; D003345:Corticosterone / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008081:Liposomes / Q000378:metabolism*; D009588:Nitrogen Mustard Compounds / Q000008:administration & dosage* / Q000494:pharmacology*; D011238:Prednimustine / Q000008:administration & dosage* / Q000494:pharmacology*
D018906:Antineoplastic Agents, Alkylating; D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D008081:Liposomes; D009588:Nitrogen Mustard Compounds; C058175:cortifen; D011238:Prednimustine; D003345:Corticosterone