title: Electrophysiological indication for a link between serotonergic neurotransmission and personality in alcoholism.
abstract: The serotonergic neurotransmission seems to be involved in the neuropsychobiology of alcoholism. The intensity dependence of the N1/P2 component of auditory-evoked potentials is discussed as an indicator of the central serotonergic neurotransmission in healthy subjects. The aim of this study was to verify this correlation between intensity dependence and serotonergic neurotransmission, as indicated by the personality trait "harm avoidance" (HA) within the Temperament and Character Inventory (TCI) in alcohol-dependent patients. The intensity dependence was measured in 25 alcohol-dependent patients, 10 and 40 days after detoxification. The personality trait HA was assessed, which is supposed to reflect the serotonergic neurotransmission. The intensity dependence was negatively correlated with the temperament trait HA of the TCI (r = - .55, P<.01) at Day 40, but neither on Day 10 nor with the other personality dimensions. We conclude, that the intensity dependence reflects the serotonergic neurotransmission in withdrawn alcohol-dependent patients.
authors.affiliation: Psychiatric Neurophysiology, Department of Psychiatry and Psychotherapy, University Hospital of Wuerzburg, Germany.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Herrmann
authors.forename: Georg
authors.initials: G
authors.lastname: Sonnek
authors.forename: H Gerd
authors.initials: HG
authors.lastname: Weijers
authors.forename: Gerhard A
authors.initials: GA
authors.lastname: Wiesbeck
authors.forename: Jobst
authors.initials: J
authors.lastname: Böning
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Fallgatter
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D017668:Age of Onset; D000437:Alcoholism / Q000503:physiopathology*; D016477:Artifacts; D004569:Electroencephalography; D004594:Electrophysiology / Q000379:methods; D005072:Evoked Potentials, Auditory / Q000502:physiology; D006801:Humans; D010551:Personality / Q000502:physiology*; D015203:Reproducibility of Results; D012701:Serotonin / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D012701:Serotonin