title: Sympathetic nervous system and the kidney in hypertension.
abstract: Long-term control of arterial pressure has been attributed to the kidney by virtue of its ability to couple the regulation of blood volume to the maintenance of sodium and water balance by the mechanisms of pressure natriuresis and diuresis. In the presence of a defect in renal excretory function, hypertension arises as the consequence of the need for an increase in arterial pressure to offset the abnormal pressure natriuresis and diuresis mechanisms, and to maintain sodium and water balance. There is growing evidence that an important cause of the defect in renal excretory function in hypertension is an increase in renal sympathetic nerve activity (RSNA). First, increased RSNA is found in animal models of hypertension and hypertensive humans. Second, renal denervation prevents or alleviates hypertension in virtually all animal models of hypertension. Finally, increased RSNA results in reduced renal excretory function by virtue of effects on the renal vasculature, the tubules, and the juxtaglomerular granular cells. The increase in RSNA is of central nervous system origin, with one of the stimuli being the action of angiotensin II, probably of central origin. By acting on brain stem nuclei that are important in the control of peripheral sympathetic vasomotor tone (e.g. rostral ventrolateral medulla), angiotensin II increases the basal level of RSNA and impairs its arterial baroreflex regulation. Therefore, the renal sympathetic nerves may serve as the link between central sympathetic nervous system regulatory sites and the kidney in contributing to the renal excretory defect in the development of hypertension.
authors.affiliation: Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA. gerald-dibona@uiowa.edu
authors.forename: Gerald F
authors.initials: GF
authors.lastname: DiBona
mesh_terms: D002908:Chronic Disease; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000294:innervation / Q000503:physiopathology*; D007674:Kidney Diseases / Q000503:physiopathology; D009474:Neurons / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000503:physiopathology*
chemical_list: D009638:Norepinephrine