[The relationship between postburn enterogenic hypermetabolism and decontamination of intestine].
OBJECTIVE
To explore whether postburn enterogenic hypermetabolism exists.


METHODS
Eighty -- eight Wistar rats inflicted by 30% TBSA III degree burns were randomly divided into two groups, i,e. burn (B) and burn with gut decontamination (D) groups. The change in resting energy expenditure (REE) was observed during 0 to 10 postburn day (PBDs) in rats. The plasma contents of lipopolysaccharide (LPS), tumor necrosis factor (TNF) and interleukin-1 (IL-1) were determined on 1, 3, 5, 7 and 10 PBDs and their correlations were analyzed.


RESULTS
The postburn REE and plasma contents of TNF, LPS and IL-1 were much higher in both groups than those before injury. When compared between the two groups, the above data in D group were lower in varying degrees than those in B group. It was shown by correlation analysis that REE was postively correlated to LPS, TNF and IL-1, respectively (gamma = 0.77 similar 0.9, P < 0.05 similar 0.01).


CONCLUSIONS
Postburn hypermetabolism in rats could be ameliorated by gut decontamination, and the postburn plasma inflammatory mediators in rats could also be lowered by gut decontmination. This suggests that enterogenic hypermetabolism does exist after burn injury.
Peng
X
X
Institute of Burn Research, Southwestern Hospital, The Third Military Medical University, Chongqing 400038, P. R. China.
Wang
S
S
Tao
L
L
Wang
F
F
Wang
P
P
You
Z
Z
D000818:Animals; D002056:Burns / Q000097:blood / Q000378:metabolism*; D005260:Female; D007375:Interleukin-1 / Q000097:blood; D007413:Intestinal Mucosa / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha