title: Network interactions mediated by new excitatory connections between CA1 pyramidal cells in rats with kainate-induced epilepsy.
abstract: Axon sprouting and synaptic reorganization in the hippocampus are associated with the development of seizures in temporal lobe epilepsy. Synaptic interactions among CA1 pyramidal cells were examined in fragments of hippocampal slices containing only the CA1 area from saline- and kainate-treated rats. Glutamate microapplication to the pyramidal cell layer increased excitatory postsynaptic current (EPSC) frequency, but only in rats with kainate-induced epilepsy. In bicuculline, action potentials evoked in single pyramidal cells increased the frequency of network bursts only in slices from rats with kainate-induced epilepsy. These data further support the hypothesis that excitatory connections between CA1 pyramidal cells increase after kainate-induced status epilepticus.
authors.affiliation: Department of Anatomy and Neurobiology, Program in Molecular, Cellular, and Integrative Neuroscience, Colorado State University, Fort Collins, CO 80523, USA. BNSmith@Tulane.edu
authors.forename: Bret N
authors.initials: BN
authors.lastname: Smith
authors.forename: F Edward
authors.initials: FE
authors.lastname: Dudek
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D018690:Excitatory Amino Acid Agonists; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D018756:GABA Antagonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000503:physiopathology*; D007608:Kainic Acid; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D018408:Patch-Clamp Techniques; D010507:Periodicity; D017966:Pyramidal Cells / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013268:Stimulation, Chemical
chemical_list: D018690:Excitatory Amino Acid Agonists; D018756:GABA Antagonists; D018698:Glutamic Acid; D007608:Kainic Acid; D001640:Bicuculline