title: Synthesis and antibacterial activity of novel 1beta-methyl carbapenems with cycloalkylamine moiety at the C-2 position.
abstract: Novel 1beta-methyl carbapenems with a cycloalkylamine moiety as a side chain were synthesized and their structure-activity relationships were studied. These carbapenems showed potent antibacterial activities against a wide range of Gram-positive and Gram-negative bacteria, and moderate urinary recovery when administered intraperitoneally in mice.
authors.affiliation: Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kawamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Shimoji
authors.forename: O
authors.initials: O
authors.lastname: Kanno
authors.forename: R
authors.initials: R
authors.lastname: Endo
authors.forename: M
authors.initials: M
authors.lastname: Miyauchi
authors.forename: K
authors.initials: K
authors.lastname: Kojima
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
authors.forename: M
authors.initials: M
authors.lastname: Morimoto
authors.forename: S
authors.initials: S
authors.lastname: Ohya
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015780:Carbapenems / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems