Role of transcription factors in the pathogenesis of pituitary adenomas: a review.
The diversity inherent in every organ has its roots in gene-expression variation and is revealed through distinctions in the molecular profile and hence the identity of individual cell type. Study into the molecular mechanisms of the development of individual cell type within the pituitary, which is under the control of transcription factors, has provided a basis for a deeper insight into the molecular mechanisms underlying the pathogenesis of a variety of hormone-producing pituitary tumors. Identification of some of these transcription factors in pituitary adenomas further supports their role in the pathogenesis of pituitary adenomas. Understanding the molecular mechanisms of regulation of proliferation of pituitary cell types by transcription factors offers a basis for hope that rational genetic or pharmacologic therapies for pituitary tumors can be designed in the future.
Suhardja
A
A
Division of Neurosurgery, St. Michael's Hospital, Toronto, Ontario, Canada.
Kovacs
K
K
Rutka
J
J
D000236:Adenoma / Q000235:genetics*; D020816:Amino Acid Motifs; D001665:Binding Sites; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000502:physiology; D047628:Estrogen Receptor alpha; D015972:Gene Expression Regulation, Neoplastic; D018257:Helix-Loop-Helix Motifs; D006801:Humans; D016350:Leucine Zippers / Q000502:physiology; D009363:Neoplasm Proteins / Q000737:chemistry / Q000502:physiology*; D010911:Pituitary Neoplasms / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos / Q000737:chemistry / Q000502:physiology; D016271:Proto-Oncogene Proteins c-myc / Q000737:chemistry / Q000502:physiology; D011960:Receptors, Estrogen / Q000737:chemistry / Q000502:physiology; D013329:Structure-Activity Relationship; D050817:Transcription Factor Pit-1; D014157:Transcription Factors / Q000737:chemistry / Q000502:physiology*; D016335:Zinc Fingers / Q000502:physiology
D004268:DNA-Binding Proteins; D047628:Estrogen Receptor alpha; D009363:Neoplasm Proteins; C494187:POU1F1 protein, human; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D011960:Receptors, Estrogen; D050817:Transcription Factor Pit-1; D014157:Transcription Factors; D004247:DNA