Structure and functional properties of the ubiquitin binding protein p62.
Several highly conserved p62 homologs have recently been isolated, e.g. the rat atypical protein kinase C-interacting protein (ZIP), the murine A170/signal transduction and adapter protein, and the human p62, a protein that binds the Src homology 2 domain of p56(lck). These proteins share striking similarity in amino acid sequence and structural motifs, thereby suggesting conserved functional properties. ZIP/p62 has been shown to play an important role as a scaffold leading to the activation of the transcription factor nuclear factor kappaB. In addition, a nuclear form of p62 has been characterized that can serve as a transcriptional co-activator. Moreover, p62 is capable of binding ubiquitin (Ub) non-covalently through its Ub-associated domain. In this review, we will focus on the structure and function of ZIP/p62.
Geetha
Thangiah
T
Department of Biological Sciences, Program in Cellular and Molecular Biosciences, 331 Funchess Hall, Auburn University, Auburn, AL 36849, USA.
Wooten
Marie W
MW
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D017874:Immediate-Early Proteins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000378:metabolism; D011506:Proteins; D000071456:Sequestosome-1 Protein; D051758:Transcription Factor TFIIH; D014157:Transcription Factors; D025801:Ubiquitin / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C490981:Gtf2h1 protein, mouse; D006360:Heat-Shock Proteins; D017874:Immediate-Early Proteins; D016328:NF-kappa B; D011506:Proteins; C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein; C101343:Sqstm1 protein, mouse; C491079:Sqstm1 protein, rat; D014157:Transcription Factors; D025801:Ubiquitin; D051758:Transcription Factor TFIIH