Amphidinolide W, a new 12-membered macrolide from dinoflagellate Amphidinium sp.
A new cytotoxic 12-membered macrolide, amphidinolide W (1), has been isolated from a marine dinoflagellate Amphidinium sp., and the structure was elucidated by spectroscopic data including (13)C-(13)C INADEQUATE correlations for its (13)C-enriched sample. The absolute stereochemistry of 1 was assigned by combination of J-based configuration analysis and modified Mosher method. Amphidinolide W (1) is the first macrolide without an exomethylene unit among all amphidinolides obtained so far.
Shimbo
Kazutaka
K
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Tsuda
Masashi
M
Izui
Naoko
N
Kobayashi
Jun'ichi
J
D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D000097442:Amphidinolides
D018942:Macrolides; C449925:amphidinolide W; D000097442:Amphidinolides