Neurobehavioural study of subchronic administration of oxydemeton-methyl (insecticide and acaricide) in rats.
Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium induced hypnosis in rats after intermittent aerosol spray inhalational exposure, for 1/2 hour daily for 7 consecutive days, compared to the saline control group. Further, ED50 +/- SEM value for haloperidol induced catalepsy, CD50 +/- SEM value for pentylenetetrazole induced seizure and CI50 +/- SEM value for electroshock (i.e. the dose of haloperidol, PTZ and intensity of electroshock producing catalepsy or positive seizure response in 50% of rats) were significantly decreased after 7 days exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect, extrapyramidal effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.
Kansal
D K
DK
Department of Pharmacology, Indira Gandhi Medical College, Shimla-171 001.
Chakrabarti
A
A
D000818:Animals; D014150:Antipsychotic Agents / Q000633:toxicity; D001462:Barbital / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002375:Catalepsy / Q000139:chemically induced; D003292:Convulsants; D004597:Electroshock; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D006220:Haloperidol / Q000633:toxicity; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009420:Nervous System / Q000187:drug effects*; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D010433:Pentylenetetrazole; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D014150:Antipsychotic Agents; D003292:Convulsants; D006993:Hypnotics and Sedatives; D007306:Insecticides; D009946:Organothiophosphorus Compounds; D001462:Barbital; C026086:methyl demeton; D006220:Haloperidol; D010433:Pentylenetetrazole