title: Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia.
abstract: A growing body of evidence indicates that vascular growth factors and their receptors are activated after stroke, and these factors may contribute to ischemic cell damage and to angiogenesis during recovery from stroke. In this review, we focus on recent evidence for roles of vascular endothelial growth factor (VEGF) and angiopoietin 1 (Ang 1) in blood-brain barrier (BBB) leakage and angiogenesis after focal cerebral ischemia.
authors.affiliation: Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA.
authors.forename: Zhenggang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Michael
authors.initials: M
authors.lastname: Chopp
mesh_terms: D042683:Angiopoietin-1; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology*; D002545:Brain Ischemia / Q000503:physiopathology*; D016228:Endothelial Growth Factors / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D008222:Lymphokines / Q000494:pharmacology / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000502:physiology*; D051379:Mice; D018919:Neovascularization, Physiologic; D051381:Rats; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D042683:Angiopoietin-1; C467628:Angpt1 protein, mouse; C467629:Angpt1 protein, rat; D016228:Endothelial Growth Factors; D008222:Lymphokines; D008562:Membrane Glycoproteins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors