title: Cytotoxic effect (on tumor cells) and in vitro antiviral activity against herpes simplex virus of synthetic spongiane diterpenes.
abstract: A series of synthetic spongiane-type diterpenes have been tested in vitro for their potential antitumor and antiherpetic activity. Although the antiviral activity of these compounds against herpes simplex virus type 2 (HSV-2) was very weak, some compounds exhibited relevant cytotoxicity in the human tumor cell lines HeLa and HEp-2. The biological activity of formyl spongianes is reported for the first time. With the present study, some structure-activity trends are suggested for the cytotoxic activity of these sponge-derived natural products.
authors.affiliation: Grupo Inmunovirología-Biogénesis, Universidad de Antioquia, A.A1226, Medellín, Colombia. labeta@catios.udea.edu.co
authors.forename: Liliana
authors.initials: L
authors.lastname: Betancur-Galvis
authors.forename: Carmen
authors.initials: C
authors.lastname: Zuluaga
authors.forename: Manuel
authors.initials: M
authors.lastname: Arnó
authors.forename: Miguel A
authors.initials: MA
authors.lastname: González
authors.forename: Ramón J
authors.initials: RJ
authors.lastname: Zaragozá
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006224:Cricetinae; D003412:Cricetulus; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004423:Ear; D005347:Fibroblasts; D006367:HeLa Cells / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D007822:Laryngeal Neoplasms; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D012867:Skin; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004224:Diterpenes; C452204:isoagatholactone