title: Yield of colonoscopy in patients with nonacute rectal bleeding: a multicenter database study of 1766 patients.
abstract: OBJECTIVE
  There are few data to guide the choice between colonoscopy and flexible sigmoidoscopy in patients with nonacute rectal bleeding, especially in younger age groups. Our aim was to determine the yield of colonoscopy for significant proximal large bowel disease in the absence of significant distal disease, with special reference to young patients.
  
  
  METHODS
  This was a retrospective study of data collected prospectively in 1766 patients (median age 57 yr, 711 women). The endoscopic database (GI-Trac) contained 152 discrete fields for data input. Multiple logistic regression analysis was performed to identify variables independently associated with the presence of isolated significant proximal disease.
  
  
  RESULTS
  Young patients had a higher percentage of normal examinations than did older patients. The incidence of diverticular disease, small polyps, large polyps, and cancer rose with increasing age. No patient aged <40 yr had an isolated proximal cancer, but 7% had other significant isolated proximal disease. There was no overall association between age and significant proximal disease in the absence of significant distal disease (p = 0.66). The only variable associated with isolated proximal disease was anemia (odds ratio = 1.81; 95% CI = 1.11-2.93; p = 0.02).
  
  
  CONCLUSIONS
  The yield of colonoscopy (beyond the range of sigmoidoscopy) for neoplasia is low in patients aged <40 yr, but other significant disease may be missed if age is the only criterion determining colonoscopy use.
authors.affiliation: Digestive Disease Center, Medical University of South Carolina, Charleston, USA.
authors.forename: H E
authors.initials: HE
authors.lastname: Mulcahy
authors.forename: R S
authors.initials: RS
authors.lastname: Patel
authors.forename: G
authors.initials: G
authors.lastname: Postic
authors.forename: M A
authors.initials: MA
authors.lastname: Eloubeidi
authors.forename: J A
authors.initials: JA
authors.lastname: Vaughan
authors.forename: M
authors.initials: M
authors.lastname: Wallace
authors.forename: A
authors.initials: A
authors.lastname: Barkun
authors.forename: P S
authors.initials: PS
authors.lastname: Jowell
authors.forename: J
authors.initials: J
authors.lastname: Leung
authors.forename: E
authors.initials: E
authors.lastname: Libby
authors.forename: N
authors.initials: N
authors.lastname: Nickl
authors.forename: S
authors.initials: S
authors.lastname: Schutz
authors.forename: P B
authors.initials: PB
authors.lastname: Cotton
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D003113:Colonoscopy / Q000379:methods* / Q000706:statistics & numerical data*; D016208:Databases, Factual / Q000706:statistics & numerical data; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D015994:Incidence; D007413:Intestinal Mucosa / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011336:Probability; D012007:Rectum; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology