title: ADCON-L and hypotension during lumbar microdiscectomy.
abstract: ADCON-L anti-adhesion gel is used as an antifibrotic agent in surgery for herniated lumbar disc. We report seven patients undergoing lumbar microdiscectomy, in whom ADCON-L gel was applied to the nerve root before closure of the surgical site. After the administration of ADCON-L, tachycardia and hypotension were noted, and were quickly and effectively reversed by i.v. fluids and ephedrine. Since its routine introduction into our practice, we have given ADCON-L on 212 occasions, with an incidence of adverse haemodynamic reactions of 3.3%. Adverse cardiovascular reactions do not appear to have been reported before.
authors.affiliation: Department of Musculoskeletal Science, Royal Liverpool University Hospital, UK.
authors.forename: S
authors.initials: S
authors.lastname: Kalogrianitis
authors.forename: P
authors.initials: P
authors.lastname: Barrett
authors.forename: I
authors.initials: I
authors.lastname: Shackleford
mesh_terms: D000328:Adult; D017586:Diskectomy; D005260:Female; D005782:Gels / Q000009:adverse effects*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D007431:Intraoperative Complications / Q000139:chemically induced*; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009930:Organic Chemicals; D013610:Tachycardia / Q000139:chemically induced
chemical_list: C104199:ADCON-L; D005782:Gels; D009930:Organic Chemicals