title: Identification of population subgroups of children and adolescents with high asthma prevalence: findings from the Third National Health and Nutrition Examination Survey.
abstract: OBJECTIVE
  To provide national estimates of asthma prevalence in African-American, Mexican American and white (non-Latino) children and adolescents using several common definitions; to evaluate familial, sociodemographic, and environmental risk factors that are independently associated with current asthma in children; and to identify subgroups at particular risk for current asthma using 2 complementary data analytic approaches.
  
  
  METHODS
  Cross-sectional study, using the Third National Health and Nutrition Examination Survey, 1988-1994.
  
  
  METHODS
  Eighty-nine mobile examination centers in the United States.
  
  
  METHODS
  Twelve thousand three hundred eighty-eight African American, Mexican American, and white (non-Latino) children and adolescents, aged 2 months through 16 years, selected from a systematic random, population-based, nationally representative sample.
  
  
  METHODS
  Current asthma, defined by caregivers who reported that their child currently had doctor-diagnosed asthma.
  
  
  RESULTS
  The overall prevalence of current asthma was 6.7% (95% confidence interval [CI], 5.6-7.8). Odds ratios for current asthma from the multiple regression analysis were 4.00 (95% CI, 2.90-5.52) for children with a parental history of asthma or hay fever, 1.94 (95% CI, 1.09-3.46) for children with body mass index (calculated as weight in kilograms divided by the square of height in meters) greater than or equal to the 85th percentile, and 1.64 (95% CI, 1.20-2.26) for children of African American ethnicity. African American and Mexican American children showed a consistent prevalence of current asthma across age while white children showed an increase in prevalence with age. The 2 highest-risk subgroups identified by the signal detection analysis were composed of children with a parental history of asthma or hay fever who were 10 years or older with a body mass index greater than or equal to the 85th percentile (31.0% current asthma), and children with a parental history who were 10 years or younger and of African American ethnicity (15.6% current asthma).
  
  
  CONCLUSIONS
  The findings from this analysis show a strong independent association between obesity and current asthma in children and adolescents, and confirm previous reports of a parental history of asthma or hay fever and African American ethnicity as additional important risk factors.
authors.affiliation: Department of Family Medicine, UCLA School of Medicine, 924 Westwood Blvd, Suite 725, Los Angeles, CA 90024, USA. mrodriguez@mednet.ucla.edu
authors.forename: Michael A
authors.initials: MA
authors.lastname: Rodríguez
authors.forename: Marilyn A
authors.initials: MA
authors.lastname: Winkleby
authors.forename: David
authors.initials: D
authors.lastname: Ahn
authors.forename: Jan
authors.initials: J
authors.lastname: Sundquist
authors.forename: Helena C
authors.initials: HC
authors.lastname: Kraemer
mesh_terms: D000293:Adolescent; D001741:Black or African American / Q000706:statistics & numerical data*; D017677:Age Distribution; D001249:Asthma / Q000175:diagnosis / Q000208:ethnology*; D002140:California / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D007223:Infant; D008297:Male; D017058:Mexican Americans / Q000706:statistics & numerical data*; D016017:Odds Ratio; D015995:Prevalence; D012044:Regression Analysis; D012307:Risk Factors; D017678:Sex Distribution; D044465:White People / Q000706:statistics & numerical data*