Antiepileptic activity of Panax ginseng against pentylenetetrazole induced kindling in rats.
In the present study, Panax ginseng was evaluated for its antiepileptic activity against pentylenetetrazole (PTZ) induced chemical kindling in rats. PTZ was injected at the dose of 30 mg/kg, i.p. on alternate days and the occurrence of generalized tonic clonic convulsions were considered as the end point. One group received Panax ginseng every day, at a dose of 100 mg/kg, 30 min prior to PTZ injection whereas the other group received an equal volume of distilled water to serve as control. In a separate group the rats were evaluated for motor performance tests after Panax ginseng. The rats treated with Panax ginseng showed significant protection as compared to vehicle treated PTZ injected rats. The study suggests to potential of Panax ginseng against seizures.
Gupta
Y K
YK
Neuropharmacology Lab, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi-110 029.
Sharma
M
M
Chaudhary
G
G
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D066298:In Vitro Techniques; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D005894:Panax; D010433:Pentylenetetrazole; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D000927:Anticonvulsants; D010433:Pentylenetetrazole