title: Assignment to chromosome 12q24.33, gene organization and splicing of the human KRAB/FPB containing zinc finger gene ZNF84.
abstract: FISH analysis was used to assign the human ZNF84 gene to chromosome 12q24.33, a region associated with recurrent breakpoints and allelic loss in several human cancers. In this report we show that the ZNF84 coding region is organized in four exons; two are dedicated to encoding the KRAB/FPB-A and KRAB/FPB-B modules, the remaining exons encode the N-terminal amino acids and C-terminal array of zinc finger units, respectively.
authors.affiliation: International Institute of Genetics and Biophysics, CNR, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rosati
authors.forename: M
authors.initials: M
authors.lastname: Rocchi
authors.forename: C T
authors.initials: CT
authors.lastname: Storlazzi
authors.forename: G
authors.initials: G
authors.lastname: Grimaldi
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D019457:Chromosome Breakage / Q000235:genetics; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000737:chemistry*; D005091:Exons / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells / Q000378:metabolism; D017404:In Situ Hybridization, Fluorescence; D007438:Introns / Q000235:genetics; D051741:Kruppel-Like Transcription Factors; D019656:Loss of Heterozygosity / Q000235:genetics; D008969:Molecular Sequence Data; D020161:Physical Chromosome Mapping; D017434:Protein Structure, Tertiary; D012326:RNA Splicing / Q000235:genetics*; D012097:Repressor Proteins; D016415:Sequence Alignment; D014157:Transcription Factors / Q000737:chemistry* / Q000235:genetics*; D016335:Zinc Fingers
chemical_list: D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D012097:Repressor Proteins; D014157:Transcription Factors; C451412:ZNF84 protein, human