Prevalence and determinants of human papillomavirus genital infection in men.
Four-hundred-forty-five husbands of women with invasive cervical carcinoma, 165 of women with in situ cervical cancer, and 717 of control women (age range 19-82 years) were interviewed and a sample of exfoliated cells from the penis obtained in seven case-control studies conducted by the International Agency for Research on Cancer. The characteristics of human papillomavirus-positive and human papillomavirus-negative husbands were compared using odds ratios and 95% confidence intervals. Thirteen per cent of the husbands of control women, 18% of the husbands of women with invasive cervical carcinoma, and 21% of the husbands of in situ cervical carcinoma women were positive for penile human papillomavirus DNA. Human papillomavirus 16 was detected in 45 husbands, human papillomavirus 18, 31 or 33 in 19, and human papillomavirus 6/11 in 6, but the majority of human papillomavirus infection (158) was with other or unspecified human papillomavirus types. The same human papillomavirus type was seldom identified in both husband and wife. The strongest variation in penile human papillomavirus infection was by country, with percentages among the husbands of control women ranging between 3% in Spain and 39% in Brazil. Having had over 50 lifetime sexual partners, compared with only one, was associated with an odds ratio of 2.3.
Franceschi
S
S
International Agency for Research on Cancer, 150 Cours Albert Thomas, F-69372 Lyon cédex 08, France.
Castellsagué
X
X
Dal Maso
L
L
Smith
J S
JS
Plummer
M
M
Ngelangel
C
C
Chichareon
S
S
Eluf-Neto
J
J
Shah
K V
KV
Snijders
P J F
PJ
Meijer
C J L M
CJ
Bosch
F X
FX
Muñoz
N
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000209:etiology / Q000821:virology*; D002278:Carcinoma in Situ / Q000209:etiology / Q000821:virology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D027383:Papillomaviridae / Q000302:isolation & purification* / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000150:complications* / Q000635:transmission; D010413:Penis / Q000166:cytology / Q000821:virology*; D015995:Prevalence; D012307:Risk Factors; D012725:Sexual Behavior; D018454:Spouses; D014412:Tumor Virus Infections / Q000150:complications* / Q000635:transmission; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000821:virology*