title: Localisation of C reactive protein in infarcted tissue sites of multiple organs during sepsis.
abstract: This report hypothesises an active role for the acute phase protein, C reactive protein (CRP), in local inflammatory reactions. This was studied in infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy. In this patient, a general acute phase protein reaction was induced, with an increase in plasma CRP. In infarction sites of kidney and liver, colocalisation of CRP and activated complement were found, whereas non-infarct sites were negative for CRP and complement. These results suggest that CRP directly participates in local inflammatory processes, possibly via complement activation, after binding of a suitable ligand.
authors.affiliation: Department of Pathology, Vrije Universiteit Medical Center ICAR-VU, 1081 HV Amsterdam, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Baidoshvili
authors.forename: R
authors.initials: R
authors.lastname: Nijmeijer
authors.forename: W K
authors.initials: WK
authors.lastname: Lagrand
authors.forename: C E
authors.initials: CE
authors.lastname: Hack
authors.forename: H W M
authors.initials: HW
authors.lastname: Niessen
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007238:Infarction / Q000378:metabolism*; D007668:Kidney / Q000098:blood supply; D008099:Liver / Q000098:blood supply; D008875:Middle Aged; D018805:Sepsis / Q000378:metabolism*
chemical_list: D002097:C-Reactive Protein