Caveolae and caveolin in immune cells: distribution and functions.
Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characterized by the presence of the protein caveolin and involved in several cellular processes, including clathrin-independent endocytosis, the regulation and transport of cellular cholesterol, and signal transduction. Recently, caveolae have been identified as providing a novel route by which several pathogens are internalized by antigen-presenting cells and as centers for signal transduction. Here, we review the distribution and role of caveolae and caveolin in mammalian immune cells.
Harris
James
J
Sir William Dunn School of Pathology, South Parks Road, OX1 3RE, Oxford, UK. james.harris@path.ox.ac.uk
Werling
Dirk
D
Hope
Jayne C
JC
Taylor
Geraldine
G
Howard
Chris J
CJ
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000382:microbiology; D021941:Caveolae / Q000276:immunology* / Q000502:physiology / Q000648:ultrastructure; D051242:Caveolin 1; D022461:Caveolins / Q000032:analysis* / Q000502:physiology*; D002784:Cholesterol / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology*; D007239:Infections / Q000276:immunology; D018448:Models, Immunological; D015398:Signal Transduction
C495540:CAV1 protein, human; D051242:Caveolin 1; D022461:Caveolins; D002784:Cholesterol