title: The "Down's" side of mitochondria.
abstract: The mechanisms involved in the development of Alzheimer disease-type pathology in patients with Down's syndrome are unclear. However, a paper published in the February 28 issue of Neuron indicates that mitochondrial dysfunction is pivotally involved.
authors.affiliation: Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
authors.forename: George
authors.initials: G
authors.lastname: Perry
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D004314:Down Syndrome / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology