[The susceptible alleles on HLA-DRB 1 of type I diabetes in children in Harbin].
OBJECTIVE
To evaluate association between type I diabetes in children and HLA-DRB1 alleles in Harbin.


METHODS
Case-control method was employed, and the PCR-SSP technique was used to identify HLA-DRB1 alleles.


RESULTS
The frequencies of DRB1 * 0301 and DR3/4 heterozygosity were significantly higher but the frequency of DR2 was significantly lower in cases than that in controls. In DR4 subtypes, the frequency of DRB1 * 0405 was higher and the frequency of DRB1 * 0406 was lower in cases than that in the controls. The difference between cases and controls in DRB1 * 0901 was not significant.


CONCLUSIONS
DRB1 * 0301 allele and DR3/4 heterozygosity were the important susceptibility and heterozygosity genes while DR2 was the most important protective gene in Harbin. The DR4 possessed double-tendency. DRB1 * 0405 conferred susceptibility and DRB1 * 0406 conferred little protection. The susceptibility conferred by DRB1 * 0901 was not certain in type I diabetes in childhood in China. This study provided useful genetic data on the study of etiology of type I diabetes mellitus.
Zhang
H
H
Department of Epidemiology, Harbin Medical University, Harbin 150001, China.
Wang
B
B
Zhao
X
X
Sun
J
J
Liang
Z
Z
Zhang
D
D
Yang
Z
Z
Sun
Y
Y
Shen
J
J
D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D002681:China / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D015804:HLA-DR4 Antigen / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male
D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D059811:HLA-DRB1 Chains; C553502:HLA-DRB1*03:01 antigen