Effect of hypertension therapy with the angiotensin-converting enzyme inhibitor lisinopril on hyperandrogenism in women with polycystic ovary syndrome.
OBJECTIVE
To investigate the effect of an angiotensin-converting enzyme inhibitor, lisinopril, on serum androgen and sex-hormone-binding globulin (SHBG) levels in hypertensive women with polycystic ovary syndrome (PCOS).


METHODS
Prospective, observational study.


METHODS
Infertility Clinic of the Sani Konukoglu Hospital, Gaziantep, Turkey.


METHODS
Ten hypertensive women with PCOS.


METHODS
Lisinopril, 10 mg/day, for 4 weeks. MAIN OUTCOME MEASURE(S)): Serum levels of gonadotropins, DHEAS, total T, free T, 17 alpha-hydroxyprogesterone (17-OHP), androstenedione, E2, SHBG, TSH, and PRL were determined.


RESULTS
Hypertension treatment with lisinopril (10 mg/day for 4 weeks) resulted in a statistically significant decrease in serum free T levels. However, there was no difference in the SHBG levels.


CONCLUSIONS
Use of lisinopril, an angiotensin-converting enzyme inhibitor, results in decreased free T levels independently of SHBG. It may affect the free T levels by affecting the ovarian renin-angiotensin system.
Hacihanefioglu
Burak
B
Infertility Unit, Department of Obstetrics and Gynecology, Sani Konukoglu Hospital, Gaziantep, Turkey. bhacihanefioglu@hotmail.com
Somunkiran
Asli
A
Mahmutoglu
Ismet
I
Sercelik
Alper
A
Toptani
Semra
S
Kervancioglu
Ertan
E
D000328:Adult; D000735:Androstenedione / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood* / Q000188:drug therapy; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D017706:Lisinopril / Q000494:pharmacology*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D011374:Progesterone / Q000031:analogs & derivatives* / Q000097:blood; D011388:Prolactin / Q000097:blood; D011446:Prospective Studies; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood
D000806:Angiotensin-Converting Enzyme Inhibitors; D006062:Gonadotropins; D012738:Sex Hormone-Binding Globulin; C002175:progesterone 17 alpha-hydroperoxide; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D011388:Prolactin; D013972:Thyrotropin; D017706:Lisinopril