title: [A case of primary pyoderma-like aspergillosis occurring in a patient with a cervical spinal cord injury].
abstract: A 65-year-old man had tetraplegia caused by a cervical spinal cord injury, and could only lie in bed with a respirator. On the 14 th day of hospitalization, a rash developed on his back. The eruption grew rapidly, and became a giant erythematous plaque with ulcer, pustules, and red papules. Direct KOH examination showed branching Aspergillus hyphae. A slide culture showed subglobose shaped vesicles with phialides. Based on these findings, the case was diagnosed as primary pyoderma-like aspergillosis caused by Aspergillus fumigatus. He was treated with bifonazole and sulfadiazine silver, and one month later no Aspergillus hyphae were observed either by direct KOH examination or by culture. The patient died about 2 months later, however, because of aggravation of his general condition. Careful observation is necessary for compromised or unmoving patients with pyoderma-like aspergillosis.
authors.affiliation: Department of Dermatology, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505 Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Yoshida
authors.forename: Toshiki
authors.initials: T
authors.lastname: Sato
authors.forename: Toshihide
authors.initials: T
authors.lastname: Akasaka
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D001228:Aspergillosis / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D002574:Cervical Vertebrae; D003646:Debridement; D003881:Dermatomycoses / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage; D016867:Immunocompromised Host; D008297:Male; D011711:Pyoderma; D012837:Silver Sulfadiazine / Q000008:administration & dosage; D013119:Spinal Cord Injuries
chemical_list: D007093:Imidazoles; C036596:bifonazole; D012837:Silver Sulfadiazine