[The clinical significance of the dynamic change in serum cardiac troponin T in burned patients].
OBJECTIVE
To evaluate the diagnostic value of serum cardiac troponin T (cTnT) in myocardial injury in burned patients.


METHODS
Sixty-two burned patients were cardiac divided into 3 groups, i.e. mild and moderate (M, n = 25), severe (S, n = 22) and extra (E, n = 15) groups on the basis of patients' severity. Radio immunoassay was adopted to detect serum cTnT and CK-MB in patients of all groups on 1, 3, 7 and 14 postburn day. Ultrasound cardiogram and ECG (electrocardiogram) were employed to monitor cardiac function. Twenty healthy volunteers were enrolled in the control group (C).


RESULTS
(1). The serum cTnT levels at all time points in patients in S and E groups were evidently higher than those in C group (P < 0.01) and paralleled very well with the severity of the patients' injuries. (2). CK-MB exhibited similar change as that of cTnT. (3). There exhibited abnormal findings with ultrasound cardiogram and ECG in five cases in E group.


CONCLUSIONS
The dynamic changes in serum cTnT and CK -- MB could well reflect the degree of the myocardial injury in burned patients, and cTnT was much more reliable as an index of myocardial injury than the serum enzymes due to its higher specificity and sensitivity.
Wang
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T
Department of Burns, Geneal Hospital of Pan Zhi Hua Steel and Iron Company, Pan Zhi Hua 617023, P.R. China.
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D002056:Burns / Q000097:blood* / Q000503:physiopathology; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D020107:Troponin T / Q000097:blood*
D007527:Isoenzymes; D020107:Troponin T; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form