[Pathomorphology of regenerative processes in mandibular fracture after sodium succinate treatment and laser magnetotherapy in an experimental setting].
Morphological reactions in tissue adjacent to mandibular angular fracture were studied in guinea pigs treated with sodium succinate and laser magnetotherapy. Due to succinate therapy the exudative component of inflammation was less expressed in comparison with the control, macrophagal reaction and neoangiogenesis were activated, the volume of damaged muscle tissue and the incidence of suppurations decreased. The number of osteoblasts increased and new bone structures acquired a lamellar pattern earlier than in the control. Sodium succinate therapy in combination with laser magnetotherapy had a more pronounced positive effect as regards activation of macrophagal reaction and neoangiogenesis and a decrease in the area of fibrosclerotic changes in the zone of damaged muscles, where newly formed myosymplasts differentiated into myotubes and even in muscle fibers. Suppuration of the wound was prevented. Bone tissue in the fracture zone formed without preliminary formation of cartilaginous tissue, which resulted in more rapid osteogenesis (lamellar bone growth in the fracture zone).
Faustov
L A
LA
Nedel'ko
N A
NA
Morozova
M V
MV
D000818:Animals; D017102:Fracture Healing / Q000187:drug effects*; D006168:Guinea Pigs; D007249:Inflammation / Q000517:prevention & control; D053685:Laser Therapy; D008264:Macrophages / Q000187:drug effects / Q000528:radiation effects; D008280:Magnetics / Q000627:therapeutic use*; D008334:Mandible / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D008337:Mandibular Fractures / Q000473:pathology* / Q000628:therapy*; D010012:Osteogenesis / Q000187:drug effects / Q000528:radiation effects; D013386:Succinates / Q000627:therapeutic use*
D013386:Succinates