Cognitive and behavioral characteristics of turner syndrome: exploring a role for ovarian hormones in female sexual differentiation.
To better understand factors contributing to behavioral development, we studied patients with Turner syndrome (TS), a disorder typically marked by prenatal onset of ovarian dysfunction. We compared girls and women (ages 12 and up) with TS (n = 21) to matched controls (n = 21) in cognitive and motor skills, as well as sex-typed personality characteristics and activity preferences. Measures were categorized (based on prior studies) as showing an average male advantage (male-superior measures), female advantage (female-superior measures), or no sex difference (sex-neutral measures). It was hypothesized that, if gonadal function contributes to behavioral development, effects of this deficiency would be more prominent on sexually differentiated than sex-neutral measures and thus that patient-control differences would be most marked for measures that show sex differences. Our findings indicated that TS patients and controls differed more on cognitive and motor domains that show sex differences than on sex-neutral domains. Patients also had more "undifferentiated" personalities and showed reduced sex-typed interests and activities. Differing experiences, as indexed by interests and activities, did not explain the observed cognitive and motor differences. These results are consistent with a role for ovarian hormones acting on the brain to influence cognitive and behavioral development, although they do not rule out other possible interpretations.
Collaer
Marcia L
ML
University of California, Los Angeles, California 90095, USA. collaer@middlebury.edu
Geffner
Mitchell E
ME
Kaufman
Francine R
FR
Buckingham
Bruce
B
Hines
Melissa
M
D000293:Adolescent; D000328:Adult; D000339:Affect / Q000502:physiology; D001519:Behavior / Q000502:physiology*; D002648:Child; D002869:Chromosome Aberrations; D003071:Cognition / Q000502:physiology*; D004967:Estrogens / Q000502:physiology* / Q000627:therapeutic use; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D009483:Neuropsychological Tests; D010053:Ovary / Q000503:physiopathology; D010551:Personality; D011340:Problem Solving; D011597:Psychomotor Performance / Q000502:physiology; D012727:Sex Characteristics; D012733:Sex Differentiation / Q000502:physiology*; D013028:Space Perception / Q000502:physiology; D011795:Surveys and Questionnaires; D014424:Turner Syndrome / Q000235:genetics / Q000503:physiopathology / Q000523:psychology*; D014705:Verbal Behavior / Q000502:physiology; D014888:Wechsler Scales
D004967:Estrogens