Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues.
Synthesis and biological evaluation of two naturally-occurring bromotyramines, moloka'iamine 1 and 3,5-dibromo-4-methoxy-beta-phenethylamine 2, together with several analogues, have been completed. Bromotyramine 2 is cytotoxic, and was found to be a potent antifoulant. Analogues 15 and 16 also displayed significant cytotoxic and antifouling activities.
Schoenfeld
Ryan C
RC
Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, USA.
Conova
Susan
S
Rittschof
Daniel
D
Ganem
Bruce
B
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001419:Bacteria / Q000254:growth & development; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014439:Tyramine / Q000031:analogs & derivatives* / Q000494:pharmacology*
C000622257:3,5-dibromo-4-methoxy-beta-phenethylamine; D000903:Antibiotics, Antineoplastic; C000622258:moloka'iamine; D014439:Tyramine