[A study on relationship between hypertension and polymorphism of ACE gene in male Yi people in Liangshan Yi autonomous prefecture, Sichuan].
OBJECTIVE
To explore relationship between polymorphism of ACE gene and hypertension.


METHODS
A cross-sectional study was conducted and PCR technique was used to analyze gene polymorphism.


RESULTS
Genotypes DD, ID and II of ACE gene accounted for 13.0% and 9.7%, 50.9% and 48.4%, and 36.1% and 41.9%, respectively, in the normotensives and hypertensives. Frequencies of I and D alleles for ACE gene were 61.6% and 66.1%, and 38.4% and 33.9%, respectively, in the normotensives and hypertensives. There was no significant difference in distribution of II, ID and DD genotypes and I/D allele frequencies of ACE gene between the hypertensives and normotensives in male Yi people.


CONCLUSIONS
Association between polymorphism of ACE gene and hypertension was uncertain.
Shan
G
G
Department of Epidemiology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005.
Wang
X
X
Qiu
C
C
Ren
C
C
Li
H
H
Wang
P
P
Wu
Z
Z
Liao
S
S
Li
X
X
Tong
S
S
Zhang
K
K
D000328:Adult; D002681:China / Q000208:ethnology; D003430:Cross-Sectional Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A