[New approaches to analysis of the interrelationship between cholinergic and dopaminergic mediator systems].
Intermediatory relationships between the cholinergic and dopaminergic neurotransmission systems were analyzed using published data and the original experimental results obtained on Daphnia magna Straus, a new test object. Based on these results, the antihaloperidol activity of a series of M- cholinoblocking agents with different receptor selectivities were studied in comparison to the new cholinoblocker pentifin exceeding in the activity the classical antiparkinsonian drugs such as cyclodol, amedin, and norakin.
Podosinovikova
N P
NP
Institute of Toxicology, Ministry of Public Health of the Russian Federation, ul. Bekhtereva 1, St. Petersburg, 193019 Russia.
Kosmachev
A B
AB
Tonkopiĭ
V D
VD
Zagrebin
A O
AO
Evdokimova
E A
EA
Maslov
A M
AM
Petrov
V V
VV
Dolgo-Saburov
V B
VB
D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology; D003621:Daphnia; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D000978:Antiparkinson Agents; D018680:Cholinergic Antagonists; D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine