title: The pharmacokinetics of methadone following co-administration with a lamivudine/zidovudine combination tablet in opiate-dependent subjects.
abstract: Methadone pharmacokinetics were determined in an open-label, within subject study in 16 methadone-maintained, non-HIV-infected subjects prior to and following administration of one lamivudine 150-mg/zidovudine 300-mg combination tablet to determine whether this antiretroviral therapy alters methadone serum concentrations. No significant differences in the mean area under the serum concentration-time curve (AUC(0-24h); 8,753 +/- 4,280 vs. 8,641 +/- 4,431 microg-h/L),oralclearance(CL/F;9.9 +/- 4.9vs. 10.3 +/- 5.5 L/h),oral volume of distribution (Vd/F; 647 +/- 465 vs. 481 +/- 305 L), maximum serum concentration (Cmax; 514 +/- 223 vs. 5,510 +/- 237 microg/L), or terminal elimination half-life (t 1/2; 55.3 +/- 61.0 vs. 35.0 +/- 17.5 h) were detected. These results suggest that methadone dose change is not likely to be necessary for patients treated with lamivudine/zidovudine combination pharmacotherapy.
authors.affiliation: Yale University School of Medicine, New Haven, Conn, USA. pmrainey@u.washington.edu
authors.forename: Petrie M
authors.initials: PM
authors.lastname: Rainey
authors.forename: Gerald H
authors.initials: GH
authors.lastname: Friedland
authors.forename: Jerry W
authors.initials: JW
authors.lastname: Snidow
authors.forename: Elinore F
authors.initials: EF
authors.lastname: McCance-Katz
authors.forename: Susan M
authors.initials: SM
authors.lastname: Mitchell
authors.forename: Laurie
authors.initials: L
authors.lastname: Andrews
authors.forename: Barbara
authors.initials: B
authors.lastname: Lane
authors.forename: Peter
authors.initials: P
authors.lastname: Jatlow
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008297:Male; D008691:Methadone / Q000097:blood / Q000493:pharmacokinetics*; D008875:Middle Aged; D009294:Narcotics / Q000493:pharmacokinetics*; D009293:Opioid-Related Disorders / Q000097:blood / Q000534:rehabilitation*; D015215:Zidovudine / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D004338:Drug Combinations; D009294:Narcotics; D019259:Lamivudine; D015215:Zidovudine; D008691:Methadone