Determination of iodine values according to Hanus using 1,3-dibromo-5,5-dimethylhydantoin (DBH): analytical methods of pharmacopeias with DBH: part 7.
USP/NF 2000 [The United States Pharmacopeia, Rockville USA, 24th ed., 2000, p. 1868, The National Formulary, 19th ed. 2000] and PH. EUR. 1997 [European Pharmacopoeia, third ed., Council of Europe, Strasbourg, 1997, pp. 63-64] determine the iodine values according to Hanus with iodine monobromide in glacial acetic acid. This reagent can be replaced by a solution of 1,3-dibromo-5,5-dimethylhydantoin (DBH) and potassium iodide or iodine in the same solvent. Both reagents yield equivalent results by means of method comparison according to Passing and Bablok [J. Clin. Chem. Clin. Biochem. 21 (1983) 709; 22, (1984) 431] in relation to the official method of PH. EUR.
Hilp
Manfred
M
Institut für Pharmazeutische Chemie der Philipps-Universität, Marbacher Weg 6, D-35032 Marburg, Germany. hilp@mailer.uni-marburg.de
D006827:Hydantoins / Q000032:analysis* / Q000138:chemical synthesis / Q000592:standards; D007455:Iodine / Q000032:analysis* / Q000737:chemistry / Q000592:standards; D010602:Pharmacopoeias as Topic / Q000592:standards
D006827:Hydantoins; D007455:Iodine; C056578:1,3-dibromo-5,5-dimethylhydantoin