title: The relationship of circulating insulin-like growth factor 1, its binding protein-3, prostate-specific antigen and C-reactive protein with disease stage in prostate cancer.
abstract: OBJECTIVE
  To assess the relationships among circulating insulin-like growth factor-1 (IGF-1), IGF binding protein-3 (IGFBP-3), prostate-specific antigen (PSA) and C-reactive protein (an indicator of inflammatory systemic response) in patients with prostate disease and cancer of different stages.
  
  
  METHODS
  Circulating IGF-1, IGFBP-3, PSA and C-reactive protein concentrations were measured in patients with BPH (17) or stages T1/T2 (15), T3/T4 (16) and metastatic prostate cancer (12 patients).
  
  
  RESULTS
  IGF-1 and IGFBP-3 concentrations were similar between patients with BPH and those with cancer, and there was no difference between the groups with cancer. In the latter patients there was a significant correlation between age and IGFBP-3 concentrations (r = -0.400, P = 0.008) but not with IGF-1 concentrations. Controlling for age, there were significant partial correlations between C-reactive protein and IGF-1 (r = -0.412, P = 0.008) and IGFBP-3 (r = -0.277, P = 0.05).
  
  
  CONCLUSIONS
  These results indicate that circulating IGF-1 and IGFBP-3 concentrations do not change with disease stage in prostate cancer, but that they decrease with an increase in the systemic inflammatory response.
authors.affiliation: University Department of Surgery, Royal Infirmary, Glasgow, UK. zaklatif@hotmail.com
authors.forename: Z
authors.initials: Z
authors.lastname: Latif
authors.forename: D C
authors.initials: DC
authors.lastname: McMillan
authors.forename: A M
authors.initials: AM
authors.lastname: Wallace
authors.forename: N
authors.initials: N
authors.lastname: Sattar
authors.forename: K
authors.initials: K
authors.lastname: Mir
authors.forename: G
authors.initials: G
authors.lastname: Jones
authors.forename: M A
authors.initials: MA
authors.lastname: Underwood
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis*; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000097:blood*
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein