title: Percutaneous assessment of coronary blood flow and cardiac biomarkers.
abstract: The aim of this study was to compare blood flow determined by coloured microspheres vs. Doppler intravascular ultrasound (US) combined with angiography. A second endpoint was to assess cardiac troponin I (cTnI) as a marker of myocardial injury. Doppler and microspheres were compared in 11 closed chest pigs. Blood flow was measured by catheter-based percutaneous technique in the left circumflex artery (LCx) and compared with coloured microspheres injected in the left ventricle. cTnI was measured in all pigs (73). The mean blood flow (mL/min-1) was 23.3 +/- 8.7 vs. 21.9 +/- 12.1 by Doppler vs. microspheres (p = 0.156), correlation coefficient r = 0.90, p = 0.006. The mean coronary flow with Doppler technique and microspheres in the middle LCx was 22.9 +/- 7.6 vs. 21.2 +/- 6.2 (p = 0.077), and distal 23.9 +/- 10.9 vs. 23.1 +/- 12.1 (p = 0.698). Coronary blood flow measured by Doppler and angiography was comparable to myocardial blood flow measured by coloured microspheres injected in the left atrium or the left ventricle. cTnI was more sensitive to ischaemia than CK-MB mass.
authors.affiliation: Department of Heart Disease, Haukeland University Hospital, Bergen, Norway. vike@haukeland.no
authors.forename: Kjell
authors.initials: K
authors.lastname: Vikenes
authors.forename: Jørgen
authors.initials: J
authors.lastname: Westby
authors.forename: Knut
authors.initials: K
authors.lastname: Matre
authors.forename: Mikael
authors.initials: M
authors.lastname: Farstad
authors.forename: Jan Erik
authors.initials: JE
authors.lastname: Nordrehaug
mesh_terms: D000818:Animals; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D008297:Male; D008863:Microspheres; D012867:Skin / Q000098:blood supply*; D013552:Swine; D019210:Troponin I / Q000097:blood*; D018084:Ultrasonography, Interventional
chemical_list: D019210:Troponin I