[Comparative study of the effectiveness of HBcAg presentation to the immune system using attenuated Salmonella strains, serovars S.enteritidis and S.typhimurium].
In this work the results of obtaining HBcAg-producing attenuated Salmonella strains, serovars S. enteritidis and S. typhimurium, and their comparative study is presented. As revealed in this study, attenuated S. enteritidis strain E-23 and S. typhimurium strain T-10, producing HBcAg, induce cell-mediated and humoral immune response to HBcAg after injected into anovals. After injection S. typhimurium strain T-10 induces a much higher titer of specific antibodies than S. enteritidis strain E-23. The level of specific antibodies induced by recombinant HBcAg seems to correlate with the capacity of salmonellae for survival inside macroorganisms.
Karpenko
L I
LI
State Research Center of Virology and Biotechnology Vector-Research Institute of Bioengineering, Closed Joint-Stock Company Vector-Best, Koltsovo, Novosibirsk Region, Russia.
Veremeĭko
T A
TA
Ignat'ev
G M
GM
Poryvaeva
V A
VA
Baĭborodin
S I
SI
Boĭchenko
M N
MN
Il'ichev
A A
AA
Vorob'ev
A A
AA
D000818:Animals; D017951:Antigen Presentation; D005822:Genetic Vectors / Q000276:immunology; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control; D006512:Hepatitis B Core Antigens / Q000235:genetics / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000235:genetics / Q000276:immunology; D018928:Immunity, Mucosal; D051379:Mice; D008807:Mice, Inbred BALB C; D010957:Plasmids / Q000235:genetics; D011995:Recombination, Genetic; D012477:Salmonella enteritidis / Q000235:genetics / Q000276:immunology*; D012486:Salmonella typhimurium / Q000235:genetics / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology
D006512:Hepatitis B Core Antigens; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic