Epidural lipomatosis secondary to indinavir in an HIV-positive patient.
A human immunodeficiency virus-positive patient receiving indinavir therapy developed a slowly progressive paraparesis. Magnetic resonance imaging findings were consistent with epidural lipomatosis. On discontinuing indinavir, symptoms gradually remitted. Although indinavir, a protease inhibitor, is known to cause abnormal fat accumulation, to the best of our knowledge this is the first report of epidural lipomatosis.
Cersósimo
María Graciela
MG
Department of Neurology and Infectious Diseases, Hospital de Clínicas "José de San Martín," U.B.A., Buenos Aires, Argentina.
Lasala
Beatriz
B
Folgar
Silvia
S
Micheli
Federico
F
D000328:Adult; D004824:Epidural Space; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D015497:HIV-1; D006801:Humans; D006987:Hypesthesia / Q000139:chemically induced; D019469:Indinavir / Q000009:adverse effects* / Q000627:therapeutic use; D007866:Leg; D008068:Lipomatosis / Q000139:chemically induced*; D008279:Magnetic Resonance Imaging; D008297:Male; D020335:Paraparesis / Q000139:chemically induced; D010292:Paresthesia / Q000139:chemically induced; D013118:Spinal Cord Diseases / Q000139:chemically induced*; D013904:Thoracic Vertebrae
D017320:HIV Protease Inhibitors; D019469:Indinavir