Generating new marine cell lines and transgenic species--conference summary.
Marine species offer a tremendous diversity of life histories, physiologies, genetics, behaviors, and biologies, reflecting myriad adaptations to the water environment. Historically, marine vertebrates, particularly fish, have played significant roles in a wide range of disciplines, including environmental toxicology, genetics, developmental biology, and physiology, among others. Much still remains to be learned from these animals, and there is a growing need for new marine models. Models for expression of marine animal genes have been limited to heterologous expression systems. While there is still a great deal to gain from heterologous expression systems, the interactions of genes with one another can best be determined in homologous expression systems where appropriate interactions are possible. This has become particularly important with the development of functional genomics in marine models. These homologous gene expression systems will be key to the use of functional genomics for marine animal molecular physiology and toxicology.
Wise
John Pierce
JP
Mount Desert Island Biological Laboratory, Salisbury Cove, Maine 04672, USA.
Winn
Richard N
RN
Renfro
J Larry
JL
D000818:Animals; D002460:Cell Line; D005399:Fishes; D005786:Gene Expression Regulation; D007448:Invertebrates; D030781:Organisms, Genetically Modified