[Effect of phenofibrate treatment on endothelial dysfunction in patients with history of myocardial infarction in young age].
OBJECTIVE
To evaluate the severity of endothelial dysfunction in patients with a history of myocardial infarction in young age and its changes during therapy with lipantil 200 M.


METHODS
The percentage of dilatation of the brachial artery during reactive hyperemia test, number of circulating desquamated endotheliocytes, and lipid metabolism parameters were evaluated in 40 men with a history of myocardial infarction before the age of 45 years and 40 healthy men.


RESULTS
Endothelial dysfunction was detected in coronary patients: the percentage of dilatation of the brachial artery was decreased, the number of circulating endotheliocytes increased, and lipid metabolism disordered. After 3-month lipantil 200 M therapy the severity of endothelial dysfunction significantly decreased and lipid metabolism parameters improved.


CONCLUSIONS
Patients with a history of myocardial infarction in young age develop endothelial dysfunction, whose severity decreases after hypolipidemic therapy.
Berkovich
O A
OA
Bazhenova
E A
EA
Volkova
E V
EV
Tolstova
I A
IA
Alugishvili
M Z
MZ
Shliakhto
E V
EV
D017668:Age of Onset; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D011345:Fenofibrate / Q000627:therapeutic use*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism / Q000503:physiopathology*
D000960:Hypolipidemic Agents; D008055:Lipids; D011345:Fenofibrate