Detection of coronary microvascular disease by means of cardiac scintigraphy.
A 76-year-old woman strictly defined as having cardiac syndrome X underwent cardiac scintigraphies. A reversible perfusion abnormality was identified by (201)thallium in the inferior segment of the left ventricle. (123)iodine meta-iodo-benzyl-guanigine uptake showed extremely diminished uptake in the inferior segment of the myocardium. (123)iodine labelled beta-methyl-iodophenyl pentadecanoic acid myocardial single photon emission computed tomography showed decreased uptake of the inferior segment in the early image, whereas the delayed images revealed significant fill-in of the tracer in the inferior segment of the myocardium. These findings suggest that coronary microvascular dysfunction causes regional myocardial ischemia, resulting in metabolic and sympathetic abnormality.
Matsuo
Shinro
S
First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan. smatsuo@belle.shiga-med.ac.jp
Nakamura
Yasuyuki
Y
Matsumoto
Tetsuya
T
Takahashi
Masayuki
M
Kinoshita
Masahiko
M
D000368:Aged; D006328:Cardiac Catheterization; D002637:Chest Pain / Q000175:diagnosis; D004359:Drug Therapy, Combination; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D020913:Perindopril / Q000008:administration & dosage; D017035:Pravastatin / Q000008:administration & dosage; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
D017256:Technetium Tc 99m Sestamibi; D007548:Isosorbide Dinitrate; D017035:Pravastatin; D020913:Perindopril