Transdermal delivery of triprolidine using TPX polymer membrane.
Triprolidine-containing matrix was fabricated with poly(4-methyl-1-pentene) (TPX) polymer to control the release of the drug. Effect of penetration enhancer and stripping of skin on the permeation of triprolidine through the excised mouse skin was studied. Penetrating enhancers showed the increased flux probably due to the enhancing effect on the skin barrier, the stratum corneum. Among enhancers used such as glycols, fatty acids and non-ionic surfactants, polyoxyethylene-2-oleyl ether showed the best enhancement. The permeability of triprolidine was markedly increased with stripping the mouse skin to remove the stratum corneum, which acts as a barrier of skin permeation. For the controlling delivery of triprolidine, the TPX matrix containing permeation enhancer could be developed.
Shin
Sang-Chul
SC
College of Pharmacy, Chonnam National University, 300 Yongbongdong, Bukku, 500-757, Kwangju, South Korea. shinsc@chonnam.chonnam.ac.kr
Kim
Jin
J
Yoon
Mi-Kyoung
MK
Oh
In-Joon
IJ
Choi
Jun-Shik
JS
D000279:Administration, Cutaneous; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D008297:Male; D008567:Membranes, Artificial; D051379:Mice; D008813:Mice, Inbred ICR; D011090:Polyenes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011108:Polymers / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology; D014311:Triprolidine / Q000008:administration & dosage* / Q000493:pharmacokinetics
D018926:Anti-Allergic Agents; D008567:Membranes, Artificial; D011090:Polyenes; D011108:Polymers; C087577:poly(4-methyl-1-pentene); D014311:Triprolidine