title: Prostaglandins as inflammatory messengers across the blood-brain barrier.
abstract: Upon immune challenge the brain launches a wide range of responses, such as fever, anorexia, and hyperalgesia that serve to maintain homeostasis. While these responses are adaptive during acute infections, they may be destructive during chronic inflammatory conditions. Research performed during the last decade has given us insight into how the brain monitors the presence of a peripheral inflammation and the mechanisms underlying the brain-mediated acute-phase reactions. Here we give a brief review on this subject, with focus on the role of prostaglandin E2 produced in cells associated with the blood-brain barrier in immune-to-brain signaling. The recent advances in this field have not only elucidated the mechanisms behind the anti-pyretic and anti-hyperalgesic effects of cyclooxygenase inhibitors, but have also identified novel and more-selective potential drug targets.
authors.affiliation: Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, University of Linköping, 581 85 Linköping, Sweden.
authors.forename: David
authors.initials: D
authors.lastname: Engblom
authors.forename: Monica
authors.initials: M
authors.lastname: Ek
authors.forename: Sipra
authors.initials: S
authors.lastname: Saha
authors.forename: Anders
authors.initials: A
authors.lastname: Ericsson-Dahlstrand
authors.forename: Per-Johan
authors.initials: PJ
authors.lastname: Jakobsson
authors.forename: Anders
authors.initials: A
authors.lastname: Blomqvist
mesh_terms: D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier; D015232:Dinoprostone / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D015213:Neuroimmunomodulation
chemical_list: D015232:Dinoprostone