Ovarian mucinous cystadenocarcinoma with virilization.
BACKGROUND
Ovarian neoplasms, other than sex cord--stromal tumors, are rare causes of hyperandrogenism. Only two cases of primary mucinous carcinomas associated with virilization have been reported.


METHODS
A 50-year-old female was referred to our clinic with a large pelvic mass. On examination she had significant facial hirsutism, clitoromegaly, and male pattern pubic hair growth. Serum levels of testosterone and dihydroepiandrosterone sulfate were elevated. A 30-cm, multilocular, solid and cystic, left ovarian mass was resected. Histology revealed moderately to poorly differentiated mucinous cystadenocarcinoma. The ovarian stroma contained florid proliferation of luteinized cells. The right ovary showed cortical stromal hyperplasia. Abnormal hormone values normalized 10 days postoperatively.


CONCLUSIONS
We report a rare case of mucinous cystadenocarcinoma with virilization, review the literature, and discuss the mechanisms of hormone production by these tumors.
Nezhat
Farr
F
Department of Pathology, Mount Sinai Medical Center, New York, New York 10029, USA.
Slomovitz
Brian M
BM
Saiz
Antonio D
AD
Cohen
Carmel J
CJ
D018282:Cystadenocarcinoma, Mucinous / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000209:etiology*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000601:surgery