title: Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age.
abstract: BACKGROUND
  People who are small at birth tend to have higher blood pressure in later life. However, it is not clear whether it is fetal growth restriction or the accelerated postnatal growth that often follows it that leads to higher blood pressure.
  
  
  RESULTS
  We studied blood pressure in 346 British men and women aged 22 years whose size had been measured at birth and for the first 10 years of life. Their childhood growth was characterized using a conditional method that, free from the effect of regression to the mean, estimated catch-up growth. People who had been small at birth but who gained weight rapidly during early childhood (1 to 5 years) had the highest adult blood pressures. Systolic pressure increased by 1.3 mm Hg (95% CI, 0.3 to 2.3) for every standard deviation score decrease in birth weight and, independently, increased by 1.6 mm Hg (95% CI, 0.6 to 2.7) for every standard deviation score increase in early childhood weight gain. Adjustment for adult body mass index attenuated the effect of early childhood weight gain but not of birth weight. Relationships were smaller for diastolic pressure. Weight gain in the first year of life did not influence adult blood pressure.
  
  
  CONCLUSIONS
  Part of the risk of adult hypertension is set in fetal life. Accelerated weight gain in early childhood adds to this risk, which is partly mediated through the prediction of adult fatness. The primary prevention of hypertension may depend on strategies that promote fetal growth and reduce childhood obesity.
authors.affiliation: MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK. claw@mrc.soton.ac.uk
authors.forename: C M
authors.initials: CM
authors.lastname: Law
authors.forename: A W
authors.initials: AW
authors.lastname: Shiell
authors.forename: C A
authors.initials: CA
authors.lastname: Newsome
authors.forename: H E
authors.initials: HE
authors.lastname: Syddall
authors.forename: E A
authors.initials: EA
authors.lastname: Shinebourne
authors.forename: P M
authors.initials: PM
authors.lastname: Fayers
authors.forename: C N
authors.initials: CN
authors.lastname: Martyn
authors.forename: M
authors.initials: M
authors.lastname: de Swiet
mesh_terms: D000328:Adult; D001724:Birth Weight; D001794:Blood Pressure / Q000502:physiology; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004739:England / Q000453:epidemiology; D005260:Female; D005333:Fetus; D005500:Follow-Up Studies; D006128:Growth / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D007223:Infant; D007230:Infant, Low Birth Weight / Q000254:growth & development* / Q000502:physiology; D007231:Infant, Newborn; D008019:Life Style; D008137:Longitudinal Studies; D008297:Male; D017678:Sex Distribution; D015430:Weight Gain