title: Fanconi's syndrome, acute renal failure, and tonsil ulcerations after colloidal bismuth subcitrate intoxication.
abstract: A 22-year-old woman ingested 5.4 g of colloidal bismuth subcitrate (CBS) in a suicide attempt. After ingestion, she presented with Fanconi's syndrome and acute renal failure to our unit. On the third day after ingestion, she was anuric. Ulcerations of both tonsils were observed 8 days after intoxication. Sodium-2,3-dimercapto-1-propanesulfonate (DMPS) is shown to be an effective chelating agent of heavy metal intoxications, but it has only a small effect on elimination of bismuth salts in patients with renal insufficiency without hemodialysis. In our case, we initiated hemodialysis and intravenous treatment with DMPS 60 hours after intoxication. By repeated measurements of bismuth concentrations in serum and dialyzed fluid, we showed its successful elimination. Serum bismuth level decreased from 640 microg/L to 15 microg/L within 6 days. With elimination of bismuth, renal function improved, and tonsil ulcerations healed. Hemodialysis was discontinued on day 14. Follow-up examination 6 weeks later showed normal renal function. Clinicians should be aware that acute renal failure and tonsil ulcerations can occur after CBS intoxication. Generally, acute renal failure caused by CBS intoxication is reversible. Treatment with the chelating agent DMPS in combination with hemodialysis is highly effective in reducing the serum bismuth level in patients with acute renal failure.
authors.affiliation: Department of Internal Medicine Clinic B, Division of Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland. petrhruz@hotmail.com
authors.forename: Petr
authors.initials: P
authors.lastname: Hruz
authors.forename: Michael
authors.initials: M
authors.lastname: Mayr
authors.forename: Roland
authors.initials: R
authors.lastname: Löw
authors.forename: Jürgen
authors.initials: J
authors.lastname: Drewe
authors.forename: Gerold
authors.initials: G
authors.lastname: Huber
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000328:Adult; D001729:Bismuth / Q000506:poisoning*; D002614:Chelating Agents / Q000627:therapeutic use; D005198:Fanconi Syndrome / Q000139:chemically induced* / Q000628:therapy; D005260:Female; D006801:Humans; D008206:Lymphatic Diseases / Q000139:chemically induced* / Q000628:therapy; D009942:Organometallic Compounds / Q000506:poisoning*; D014066:Palatine Tonsil; D006435:Renal Dialysis; D013406:Suicide, Attempted; D014456:Ulcer / Q000139:chemically induced* / Q000628:therapy; D014494:Unithiol / Q000627:therapeutic use
chemical_list: D002614:Chelating Agents; D009942:Organometallic Compounds; D014494:Unithiol; C002791:bismuth tripotassium dicitrate; D001729:Bismuth