Nematocidal activity of isoquinoline alkaloids against a species of diplogastridae.
We examined the nematocidal activity of various isoquinoline alkaloids. The method of evaluating nematocidal activity involved the microscopic examination of the state of larvae after the compound was administered to determine the minimum lethal concentration (MLC). In addition, cytotoxic activity (IC50) was examined using HL-60 culture cells. The compound dehydrocorydaline was found to have considerable nematocidal activity and weak cytotoxicity; its cytotoxicity value was equal to that of thiabendazole. We conclude that dehydrocorydaline, with its attractive balance between nematocidal activity and weak cytotoxicity, is the most promising of the tested compounds as a possible remedy for parasitic diseases.
Matsuhashi
Rinako
R
Satou
Tadaaki
T
Koike
Kazuo
K
Yokosuka
Akihito
A
Mimaki
Yoshihiro
Y
Sashida
Yutaka
Y
Nikaido
Tamotsu
T
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000302:isolation & purification / Q000494:pharmacology*; D009348:Nematoda / Q000187:drug effects*; D028101:Papaveraceae; D013827:Thiabendazole / Q000494:pharmacology
D000470:Alkaloids; D000969:Antinematodal Agents; D004365:Drugs, Chinese Herbal; D007546:Isoquinolines; C007232:dehydrocorydalin; C039109:isoquinoline; D013827:Thiabendazole