title: [Reactions to and immunogenic properties of the combined vaccine Bubo-M for immunization of children against diphtheria, tetanus and viral hepatitis B].
abstract: Bubo-M, the first Russian combined vaccine, was found to have low reactogenicity. The difference between the number of postvaccinal reactions in the group of children immunized with Bubo-M (25.9%) and those in the group of children who had been simultaneously injected into different sites of the body with ADS-M toxoid (adsorbed DT toxoid with reduced antigen content) and hepatitis B vaccine (26.7%) was not statistically significant. Following immunization a considerable increase in the level of diphtheria and tetanus antibodies (p < 0.005) was observed in all children (100%), the level of HBs antibodies in the group of children immunized with Bubo-M (the geometric mean titer: 13,721 IU/l) essentially exceeding that observed in the control group injected with ADS-M toxoid and hepatitis B vaccine (the geometric mean of the titer: 2,441 IU/l). Bubo-M was duly registered and allowed for industrial production and medical use.
authors.affiliation: State Medical Academy, Perm, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Fel'dblium
authors.forename: N N
authors.initials: NN
authors.lastname: Vorob'eva
authors.forename: A M
authors.initials: AM
authors.lastname: Nikolaeva
authors.forename: V N
authors.initials: VN
authors.lastname: Borisova
authors.forename: V A
authors.initials: VA
authors.lastname: Mel'nikov
authors.forename: M V
authors.initials: MV
authors.lastname: Budanov
authors.forename: I A
authors.initials: IA
authors.lastname: Iakovleva
authors.forename: A V
authors.initials: AV
authors.lastname: Kaz'ianin
authors.forename: E V
authors.initials: EV
authors.lastname: Pushkareva
authors.forename: V N
authors.initials: VN
authors.lastname: Griaznov
authors.forename: D V
authors.initials: DV
authors.lastname: Griaznova
authors.forename: N V
authors.initials: NV
authors.lastname: Shalunova
authors.forename: O V
authors.initials: OV
authors.lastname: Perelygina
authors.forename: N A
authors.initials: NA
authors.lastname: Ozeretskovskiĭ
authors.forename: T A
authors.initials: TA
authors.lastname: Bektimirov
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis*; D002648:Child; D003017:Clostridium tetani / Q000276:immunology*; D003353:Corynebacterium diphtheriae / Q000276:immunology*; D004165:Diphtheria / Q000517:prevention & control; D022422:Diphtheria-Tetanus Vaccine / Q000008:administration & dosage / Q000276:immunology*; D006509:Hepatitis B / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000032:analysis*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D013742:Tetanus / Q000517:prevention & control; D014611:Vaccination; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D022422:Diphtheria-Tetanus Vaccine; D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D017778:Vaccines, Combined