title: Hansenula anomala outbreak at a surgical intensive care unit: a search for risk factors.
abstract: During a 5-month period, Hansenula anomala (H. anomala), an opportunistic fungus, caused an outbreak of infections in eight adult patients treated at a surgical intensive care unit (ICU). The source of the infections and route of transmission could not be identified. A case-control study included 32 patients treated simultaneously at the surgical ICU. Univariate analysis pointed to the following significant risk factors: blood alkalosis, reduced urea, duration of hospitalization, bacteremia and colonization with Pseudomonas aeruginosa, and an APACHE II score >17 (during bacteremia or fungemia). The stepwise logistic regression multivariate analysis showed only the duration of blood alkalosis to be significant in case patients.
authors.affiliation: Institute of Clinical and Molecular Microbiology, Zagreb Clinical Hospital Center, Croatia. skalenic@mamef.mef.hr
authors.forename: S
authors.initials: S
authors.lastname: Kalenic
authors.forename: M
authors.initials: M
authors.lastname: Jandrlic
authors.forename: V
authors.initials: V
authors.lastname: Vegar
authors.forename: N
authors.initials: N
authors.lastname: Zuech
authors.forename: A
authors.initials: A
authors.lastname: Sekulic
authors.forename: E
authors.initials: E
authors.lastname: Mlinaric-Missoni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D017523:Croatia / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D016469:Fungemia / Q000453:epidemiology*; D006801:Humans; D007362:Intensive Care Units; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010843:Pichia / Q000187:drug effects / Q000302:isolation & purification*; D012307:Risk Factors