title: Stereocontrolled total synthesis of (+)-vinblastine.
abstract: A stereocontrolled total synthesis of (+)-vinblastine was accomplished, featuring preparations of the two indole units by means of a novel indole synthesis via radical cyclization of thioanilide, and a stereoselective coupling of these units.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yokoshima
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ueda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Ayato
authors.initials: A
authors.lastname: Sato
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kuboyama
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Tokuyama
authors.forename: Tohru
authors.initials: T
authors.lastname: Fukuyama
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D030008:Catharanthus / Q000737:chemistry; D013237:Stereoisomerism; D014747:Vinblastine / Q000138:chemical synthesis*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine