Expression of 5-HT3 receptors in primary sensory neurons of the petrosal ganglion of adult rats.
By using a specific antiserum, expression of the 5-HT3 receptor was examined in the petrosal ganglion (PG) of adult male rats. We found that the 5-HT3 receptors are widely distributed in the PG. This finding was confirmed by RT-PCR detection of the 5-HT3 receptor mRNA in the tissue. Unlike the distribution patterns of tyrosine hydroxylase (TH), which occurred in limited regions of PG, the 5-HT3 receptors seemed to distribute throughout the ganglion. As many TH-positive neurons in PG innervate type I cells in the carotid body, the coexistence of 5-HT3 receptor and TH in some neurons suggests that this receptor may play a role in carotid body chemoreception.
Wang
Zun-Yi
ZY
Department of Surgical Sciences, University of Wisconsin-Madison, 53706, USA. zwang@svm.vetmed.wisc.edu
Keith
Ingegerd M
IM
Olson
E Burt
EB
Vidruk
Edward H
EH
Bisgard
Gerald E
GE
D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002344:Carotid Body / Q000502:physiology*; D002395:Catecholamines / Q000096:biosynthesis; D017950:Ganglia, Sensory / Q000166:cytology / Q000378:metabolism*; D005930:Glossopharyngeal Nerve / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009475:Neurons, Afferent / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000235:genetics / Q000378:metabolism*; D044406:Receptors, Serotonin, 5-HT3; D012018:Reflex / Q000502:physiology; D012701:Serotonin / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*; D017833:Visceral Afferents / Q000166:cytology / Q000378:metabolism*
D002395:Catecholamines; D012333:RNA, Messenger; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012701:Serotonin; D014446:Tyrosine 3-Monooxygenase