Assamicin I and II, novel triterpenoid saponins with insulin-like activity from Aesculus assamica Griff.
Two novel triterpenoid saponins with insulin-like activity, termed assamicin I and II, were isolated from the roots of Aesculus assamica Griff. and their structures were characterized as 1 and 2, respectively. They inhibited release of free fatty acids from epinephrine-treated rat adipocytes and enhanced glucose uptake into 3T3-L1 adipocytes.
Sakurai
Takashi
T
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Nishimura
Toshio
T
Otake
Noboru
N
Xinsheng
Yao
Y
Abe
Keiichi
K
Zeida
Mitsuhiro
M
Nagasawa
Hiromichi
H
Sakuda
Shohei
S
D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D051379:Mice; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D012503:Saponins; C461196:assamicin I; C461197:assamicin II; D005947:Glucose; D004837:Epinephrine