title: Sequential experimentation in product development. I.
abstract: Investigations proceed as an iterative and recursive learning process, involving a sequence of experiments. Evaluating the results from a prior set of experiments allows the investigator to design and predict the next experimental cycle better. The investigator looks at what has gone before with a view to improve and extend the inquiry. This communication reiterates the value of sequential experimentation in product development. A fluid-bed granulation study is used to illustrate the sequential approach. Acceptable solutions were achieved using technical knowledge, a sequence of factorial designs, and graphical data analysis.
authors.affiliation: Sanofi-Synthelabo, 9 Great Valley Parkway, Malvern, PA 19355, USA. anil.menon@sanofi-synthelabo.com
authors.forename: Anil
authors.initials: A
authors.lastname: Menon
authors.forename: Sibu
authors.initials: S
authors.lastname: Chakrabarti
authors.forename: Nadhamuni
authors.initials: N
authors.lastname: Nerella
mesh_terms: D010865:Pilot Projects; D012107:Research Design; D013678:Technology, Pharmaceutical