title: [The change of intestinal microcirculation blood flow and its relationship with bacterial translocation in burned rats receiving delayed fluid resuscitation].
abstract: OBJECTIVE
  To investigate the change of intestinal microcirculation blood flow and its relationship with bacterial translocation in burned rats receiving delayed fluid resuscitation.
  
  
  METHODS
  Twenty-four Wistar rats inflicted by 30% TBSA III degree followed by delayed fluid resuscitation were taken as the model. The rats were randomly divided into four groups, i.e. burn shock without resuscitation (BSNR), delayed resuscitation (fluid given from 8 hours postburn, DR), immediate resuscitation (IR), and sham operation (SO). The incidence of bacterial translocation, intestinal microcirculation blood flow volume of intestinal wall at terminal ileum as well as the change of systemic mean arterial pressure were monitored.
  
  
  RESULTS
  The incidence of bacterial translocation in DR group (54.2%) was significantly higher than that in IR group (P < 0.01), but no remarkable difference with that in BS group (P < 0.05). In addition, microcirculation blood flow of intestinal wall recovered to some degree at 4 hours after delayed fluid resuscitation but far below that in IR group at the same time point. Nevertheless, the systemic mean arterial blood pressure had restored to the normal range at that time.
  
  
  CONCLUSIONS
  The incidence of intestinal bacterial translocation sustained at high level after burn shock with delayed fluid resuscitation, which might be the result of delayed improvement of microcirculation blood flow of the intestinal wall.
authors.affiliation: Department of Burn and Plastic Surgery, 187th Hospital of People's Liberation Army, Haikou, 571159, China.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Xiao
authors.forename: J
authors.initials: J
authors.lastname: Yuan
mesh_terms: D000818:Animals; D018988:Bacterial Translocation; D002056:Burns / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D005440:Fluid Therapy; D007422:Intestines / Q000098:blood supply*; D008833:Microcirculation; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow; D013997:Time Factors