Case report. Phaeohyphomycosis caused by Phialophora verrucosa developed in a patient with non-HIV acquired immunodeficiency syndrome.
A 53-year-old woman had asymptomatic multiple nodules on her gluteal region for 6 months. She had a history of systemic corticosteroid treatment for Evans' syndrome. Recently she had developed an immunodeficiency condition with CD4+ cell depletion without an HIV infection and a normal serum gamma globulin level. A smear from the purulent exudate of the nodules revealed many brown-coloured hyphae, spores and few large dark-brown cells. A short, hairy, dark-brown coloured colony was cultivated on Sabouraud glucose agar. Slide culturing revealed only a Phialophora-type conidia formation, and the fungus was diagnosed as Phialophora verrucosa. Severe immunosuppressive condition (non-HIV acquired immunodeficiency syndrome) of this patients after systemic corticosteroid treatment for Evans' syndrome predisposed an opportunistic cutaneous fungal infection due to P. verrucosa. Cases with cutaneous infection due to P. verrucosa reported in Japan are summarized and discussed.
Ohira
S
S
Isoda
K
K
Hamanaka
H
H
Takahashi
K
K
Nishimoto
K
K
Mizutani
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000139:chemically induced / Q000150:complications*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D003881:Dermatomycoses / Q000150:complications* / Q000382:microbiology; D017809:Fatal Outcome; D005260:Female; D018023:HIV Seronegativity; D006801:Humans; D007564:Japan; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications*; D010676:Phialophora / Q000302:isolation & purification*; D011239:Prednisolone / Q000009:adverse effects; D012867:Skin / Q000382:microbiology
D000893:Anti-Inflammatory Agents; D011239:Prednisolone