[The role of endotoxin of gram negative bacteria in the pathogenesis of atherosclerosis].
Literature data and the results of own research on the role played by lipopolysaccharide (endotoxin) of Gram negative bacteria in the initiation and progressing of atherosclerosis are summarized. Endotoxin promotes activation of all cells taking part in the formation of atherosclerotic plaques, induces the transformation of macrophages of arterial intima into foam cells as well as endothelial lesions and hyperlipidemia, reduces the ratio of cholesterol in lipoproteins of high specific density to total blood cholesterol. With chlamydiae and enterobacteria used as examples, the role of Gram negative bacteria and their endotoxin in the etiology and pathogenesis of atherosclerosis is discussed.
Likhoded
V G
VG
Institute of General and Clinical Pathology, Clinical Diagnostics Society, Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
Iakovlev
M Iu
MIu
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology* / Q000382:microbiology; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D008076:Cholesterol, HDL / Q000737:chemistry / Q000378:metabolism; D004730:Endothelium, Vascular / Q000473:pathology; D004731:Endotoxins / Q000378:metabolism / Q000502:physiology*; D005487:Foam Cells / Q000473:pathology; D006090:Gram-Negative Bacteria / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006949:Hyperlipidemias / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D017539:Tunica Intima / Q000276:immunology
D008076:Cholesterol, HDL; D004731:Endotoxins; D002784:Cholesterol