[GM-CSF in the culture supernatants of neutrophils and serum levels in patients with inflammation and squamous cell carcinoma of oral cavity].
The aim of this study was to comparison GM-CSF concentrations in the culture supernatants of neutrophils (unstimulated and LPS-stimulated) and the serum of patients with inflammation and squamous cell carcinoma of oral cavity. PMN from both patient groups exhibited decreased the ability to release of GM-CSF. PMN from patients with inflammation secreted a lower concentrations of GM-CSF than those from cancer patients. PMN from patients with inflammation were more reactivity after LPS-stimulation in comparison with cells from cancer group. GM-CSF serum levels in patients with inflammation and cancer were nonsignificantly higher in comparison with control. There was no correlation between GM-CSF in the culture supernatants of PMN and the serum levels in patient groups. The decreased GM-CSF production may lead to unfavourable effects for immune response of patients with inflammation as well as patients with cancer disease.
Jabłońska
E
E
Zakład Immunologii AM w Białymstoku.
Piecuch
J
J
Piotrowski
L
L
Grabowska
Z
Z
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis* / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood*; D009504:Neutrophils / Q000276:immunology*
D016178:Granulocyte-Macrophage Colony-Stimulating Factor