Comparative analysis of the human dystrophin and utrophin gene structures.
We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.
Pozzoli
Uberto
U
IRCCS E. Medea, Associazione La Nostra Famiglia, 23842 Bosisio Parini, LC, Italy. msironi@bp.lnf.it
Sironi
Manuela
M
Cagliani
Rachele
R
Comi
Giacomo P
GP
Bardoni
Alessandra
A
Bresolin
Nereo
N
D003598:Cytoskeletal Proteins / Q000235:genetics*; D016189:Dystrophin / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics*; D022821:RNA Splice Sites / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D049411:Utrophin
D003598:Cytoskeletal Proteins; D016189:Dystrophin; D008565:Membrane Proteins; D022821:RNA Splice Sites; C483599:UTRN protein, human; D049411:Utrophin