[Application possibilities of dynamic laser light scattering photometry for the examination of poly(ethylene glycol) suppositories].
Status epilepticus is one of the most common neurologic emergencies in children, adolescents, and young adults. The advantage of diazepam suppository in medicinal therapy appears mainly in treatment of childhood epilepsy. A hydrophilic suppository base was investigated in solution by dynamic light scattering and results were compared to those of the membrane diffusion experiments measuring diazepam solubilization. According to the dynamic laser light scattering photometric measurements, the good solubilization effect of the macrogol mixture (5% Polysorbatum 20, 10% Macrogolum 400, 85% Macrogolum 1540) is explained by the formation of small, tight micellas. As the Polysorbatum 20 tenside resulted in the significant decrease (p < 0.05) of the formation of great micellas, its use led to the formation of small, tight, almost monodisperse micellas of 40-50 nm in the aqueous solution of the macrogol mixture.
Bácskay
I
I
Debreceni Egyetem, Gyógyszerésztudományi Intézet, 4010 Debrecen, Egyetem tér 1.
Kéki
S
S
Deák
G
G
Zsuga
M
M
Mezey
G
G
D003975:Diazepam / Q000737:chemistry; D005079:Excipients; D007834:Lasers; D011092:Polyethylene Glycols / Q000737:chemistry*; D012542:Scattering, Radiation; D012996:Solutions; D013488:Suppositories
D005079:Excipients; D012996:Solutions; D013488:Suppositories; D011092:Polyethylene Glycols; D003975:Diazepam