Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine.
Here we report the identification of inbred miniature swine that failed to produce human-tropic replication-competent porcine endogenous retroviruses (HTRC PERVs), using in vitro coculture assays. When HTRC PERVs were isolated from transmitting animals, all were recombinant viruses, with the receptor-binding domain of PERV-A combining with PERV-C-related sequences.
Oldmixon
Beth A
BA
Immerge BioTherapeutics, Inc., Charlestown, Massachusetts02129, USA.
Wood
James C
JC
Ericsson
Thomas A
TA
Wilson
Carolyn A
CA
White-Scharf
Mary E
ME
Andersson
Goran
G
Greenstein
Julia L
JL
Schuurman
Henk-Jan
HJ
Patience
Clive
C
D000818:Animals; D017849:Animals, Inbred Strains; D001483:Base Sequence; D002460:Cell Line; D002478:Cells, Cultured; D018920:Coculture Techniques; D020077:Endogenous Retroviruses / Q000235:genetics* / Q000502:physiology*; D015752:Genes, env; D006801:Humans; D007963:Leukocytes, Mononuclear; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D013556:Swine, Miniature / Q000821:virology*; D014779:Virus Replication