title: Synthesis of a new class of chiral 1,5-diphosphanylferrocene ligands and their use in enantioselective hydrogenation.
abstract: A new family of ferrocenylphosphane ligands has been prepared. Their flexible synthesis allows many structural modifications. The asymmetric induction of these ligands was examined in the hydrogenation of functionalized C=C, C=O, and C=N bonds. The enantioselectivity of the reaction was strongly dependent on the substituent R at the position alpha to the ferrocene moiety. In many cases, both enantiomeric beta-hydroxyesters of the reduction product can be obtained by simply replacing a dimethylamino group in the ligand with a methyl group.
authors.affiliation: RHODIA Recherches, Centre de Recherche de Lyon Groupe Catalyse 85 avenue des Frères Perret, 69192 Saint Fons, France.
authors.forename: Tania
authors.initials: T
authors.lastname: Ireland
authors.forename: Katja
authors.initials: K
authors.lastname: Tappe
authors.forename: Gabi
authors.initials: G
authors.lastname: Grossheimann
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel