Enantiospecific, stereospecific total synthesis of (+)-majvinine, (+)-10-methoxyaffinisine, and (+)-N(a)-methylsarpagine as well as the total synthesis of the Alstonia bisindole macralstonidine.
[structure: see text] The enantiospecific stereospecific total synthesis of majvinine 1a, 10-methoxyaffinisine 1b, and N(a)-methylsarpagine 1c are reported; this method has also resulted in the total synthesis of the Alstonia bisindole macralstonidine 2.
Zhao
Shuo
S
Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA.
Liao
Xuebin
X
Cook
James M
JM
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism
C467068:10-methoxyaffinisine; D000470:Alkaloids; D000962:Antimalarials; D007211:Indoles; C467066:N(a)-methylsarpagine; C467067:macralstonidine; C467069:majvinine