title: The synthesis and biological characterization of a ceramide library.
abstract: A facile synthesis of a combinatorial ceramide library and their activities in the NF-kappaB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-kappaB activating molecule was discovered among ceramide containing beta-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, San Diego, California 92037, USA.
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
authors.forename: Jaehwa
authors.initials: J
authors.lastname: Choi
authors.forename: Sheng
authors.initials: S
authors.lastname: Ding
authors.forename: Eva E
authors.initials: EE
authors.lastname: Prieschl
authors.forename: Thomas
authors.initials: T
authors.lastname: Baumruker
authors.forename: Jae-Mok
authors.initials: JM
authors.lastname: Lee
authors.forename: Sung-Kee
authors.initials: SK
authors.lastname: Chung
authors.forename: Peter G
authors.initials: PG
authors.lastname: Schultz
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002518:Ceramides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000502:physiology; D020650:Combinatorial Chemistry Techniques; D006801:Humans; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D020298:U937 Cells
chemical_list: D002518:Ceramides