Effects of dietary protein of proso millet on liver injury induced by D-galactosamine in rats.
In this paper, we examined the effects of dietary protein from proso millet on liver injury induced by D-galactosamine or carbon tetrachloride in rats using serum enzyme activities as indices. D-galactosamine-induced elevations of serum activities of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase were significantly suppressed by feeding the diet containing 20% protein of proso millet for 14 days as compared with those of rats fed a 20% casein diet, but not in the case of carbon tetrachloride. The results showed that proso millet protein is effective at lower dietary protein levels than that of dietary gluten reported previously. Therefore, the findings reported here may suggest that proso millet protein is considered to be another preventive food for liver injury.
Nishizawa
Naoyuki
N
Department of Agro-Bioscience, Faculty of Agriculture, Iwate University, Morioka, Japan. nisizawa@iwate-u.ac.jp
Sato
Daiki
D
Ito
Yoshiaki
Y
Nagasawa
Takashi
T
Hatakeyama
Yasuko
Y
Choi
Myeong-Rak
MR
Choi
You-Young
YY
Wei
Yi Min
YM
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000494:pharmacology; D004044:Dietary Proteins / Q000378:metabolism / Q000494:pharmacology*; D005688:Galactosamine / Q000494:pharmacology*; D006128:Growth / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000293:injuries* / Q000378:metabolism; D008297:Male; D008897:Panicum; D051381:Rats; D017208:Rats, Wistar
D004044:Dietary Proteins; D005688:Galactosamine; D002251:Carbon Tetrachloride; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase