Novel transdermal targeting in steroid therapy: evaluation of PK/PD profiles using an animal model of rheumatoid arthritis.
Komuro
M
M
Pharmacokinetics Research Laboratory, Taiho Pharmaceutical Co., Ltd., 224-2, Ebisuno, Hiraishi, Kawauchi-cho, Tokushima 771-0194, Japan. m-komuro@taiho.co.jp
Kakuo
H
H
Sawada
K
K
Kawaguchi
Y
Y
D000279:Administration, Cutaneous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D016503:Drug Delivery Systems; D005528:Foot / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects; D011239:Prednisolone / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051381:Rats
D000893:Anti-Inflammatory Agents; D011239:Prednisolone