title: [Efficacy of the sparfloxacin-ethambutol combination in a case of cerebral tuberculosis].
abstract: BACKGROUND
  Treatment of cerebral tuberculomas demands the combination of rifampicin, isoniazid, pyrazinamide and ethambutol. The place of fluoroquinolones remains to be defined.
  
  
  METHODS
  A 36-year-old woman presented with a cerebral tuberculoma. Treatment with an antituberculous quadritherapy regimen was begun, but because of serious side effects, isoniazid and rifampicin weren't withdrawn during the fourth month. Sparfloxacin and ethambutol biotherapy was then started and continued for 12 months, which led to the disappearance of the cerebral lesion.
  
  
  CONCLUSIONS
  Our observation proves that sparfloxacin is an alternative for cerebral tuberculoma treatment in case of intolerance or resistance to first-line antituberculosis drugs.
authors.affiliation: Services de neurologie, hôpital Beaujon, 100, boulevard du Général-Leclerc, 92110 Clichy, France. yboukriche@invivo.edu
authors.forename: Y
authors.initials: Y
authors.lastname: Boukriche
authors.forename: C
authors.initials: C
authors.lastname: Masson
authors.forename: V
authors.initials: V
authors.lastname: Zarrouk
authors.forename: B
authors.initials: B
authors.lastname: Fantin
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004977:Ethambutol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects; D012293:Rifampin / Q000009:adverse effects; D020306:Tuberculosis, Central Nervous System
chemical_list: D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D024841:Fluoroquinolones; D004977:Ethambutol; C061363:sparfloxacin; D007538:Isoniazid; D012293:Rifampin