title: The use of naloxone in small doses in complex therapy of postabstinent heroin syndrome: enkephalinase mechanisms.
abstract: The use of naloxone hydrochloride (0.2-0.4 mg) in complex therapy of adolescent heroin addicts significantly prolonged the half-life of serum leu-enkephalin, slightly elevated the thresholds of thermal nociceptive reactions, and improved some clinical indices (considerably reduced drug addiction, eliminated affective disorders, etc.), which are important for deactualization of drug addiction and promoting remission.
authors.affiliation: Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov Moscow State University. shulg@protein.bio.msu.ru
authors.forename: S V
authors.initials: SV
authors.lastname: Litvinova
authors.forename: A V
authors.initials: AV
authors.lastname: Nadezhdin
authors.forename: V V
authors.initials: VV
authors.lastname: Shul'govskii
authors.forename: A L
authors.initials: AL
authors.lastname: Kalyuzhnyi
authors.forename: S N
authors.initials: SN
authors.lastname: Avdeev
authors.forename: E Y
authors.initials: EY
authors.lastname: Tetenova
authors.forename: N N
authors.initials: NN
authors.lastname: Terebilina
authors.forename: L F
authors.initials: LF
authors.lastname: Panchenko
mesh_terms: D000293:Adolescent; D000367:Age Factors; D003932:Heroin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D019966:Substance-Related Disorders; D013696:Temperature; D013997:Time Factors
chemical_list: D009292:Narcotic Antagonists; D009270:Naloxone; D003932:Heroin