title: Posttraumatic expression of MHC II molecules: an experimental and clinical study.
abstract: OBJECTIVE: To evaluate the role of MHC II expression in posttrauma immune disturbances and infections. METHODS: In experimental study, peritoneal macrophages were harvested from traumatized mice and treated with GM-CSF, Ia molecules were determined by flow cytometry. In 24 trauma patients, monocyte HLA-DR expression was measured by APAAP technique. RESULTS: Marked inhibition of MHC II molecule expression was found in both traumatized mice and patients. In traumatic patients with infection, the inhibition was more severe. Treatment with GM-CSF in mice partially restored the Ia expression. CONCLUSIONS: Inhibition of MHC II molecules plays an important role in postrauma immune disturbances. There is a close relationship between HLA-DR inhibition and clinical infections.
authors.affiliation: Emergency Center, Jinling Hospital, Nanjing 210002, China.
authors.forename: Haichen
authors.initials: H
authors.lastname: Sun
authors.forename: Xuehao
authors.initials: X
authors.lastname: Wu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Qian
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Qi
authors.forename: Wenjie
authors.initials: W
authors.lastname: Tang
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Xu
authors.forename: Jieshou
authors.initials: J
authors.lastname: Li