title: [A clinico-pathological and etiological study of Binswanger's Disease].
abstract: OBJECTIVE
  To study the pathology, incidence and etiology of Binswanger's disease.
  
  
  METHODS
  Autopsied brains from 9 cases of Binswanger's disease and 13 cases of non-demented elderly individuals were studied by clinico-pathological, immunohistochemical and micrometer methods.
  
  
  RESULTS
  The lesions of Binswanger's disease were mainly located in the subcortical white matter, periventrical regions, brainstem and cerebellum. The pathological changes were demyelination, lacunar infarction, gliosis and dilatation of perivascular space (Virchow-Robin space, VR space, P < 0.01). The wall thickness of deeply penetrating arteries in the white matter was significantly increased (P < 0.01).
  
  
  CONCLUSIONS
  Binswanger's disease is not a rare entity. The findings of this study suggest that arteriosclerosis is a primary factor in the pathogenesis of Binswanger's disease.
authors.affiliation: Department of Pathology, Beijing Hospital, Beijing 100730.
authors.forename: D
authors.initials: D
authors.lastname: Liu
authors.forename: G
authors.initials: G
authors.lastname: You
authors.forename: J
authors.initials: J
authors.lastname: Wei
authors.forename: Z
authors.initials: Z
authors.lastname: Sun
authors.forename: K
authors.initials: K
authors.lastname: Man
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000150:complications / Q000473:pathology; D001921:Brain / Q000098:blood supply / Q000473:pathology; D015140:Dementia, Vascular / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male