Functional changes in temporal lobe activity during transient global amnesia.
The integrity of temporal lobe activity during and after recovery from transient global amnesia (TGA) was assessed in a case study using functional MRI. TGA was associated with scene-encoding deficits in a temporolimbic circuit that recovered over time. Frontoparietal areas recruited during the amnesic state may signify a compensatory reliance on visuospatial or working memory strategies. Reduction of extrastriate cortex responses over repeated testing sessions possibly indicates intact visual priming in TGA.
LaBar
Kevin S
KS
Center for Cognitive Neuroscience, Duke University, Durham, NC 27708-0999, USA. klabar@duke.edu
Gitelman
Darren R
DR
Parrish
Todd B
TB
Mesulam
M Marsel
MM
D000328:Adult; D020236:Amnesia, Transient Global / Q000175:diagnosis* / Q000503:physiopathology; D001921:Brain / Q000502:physiology / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D020127:Recovery of Function / Q000502:physiology