Cdk1/P34Cdc2 and P21waf expression in colorectal adenomas and carcinomas.
p21WAF1,CIP1,SDI 1 is a specific inhibitor of cyclin-dependent kinase and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Cdk1/p34cdc2 plays a crucial role during mitosis. The immunoreactivity of p21 WAF1,CIP1,SDI 1 and cdk1/p34cdc2 was evaluated in adenomas and adenocarcinomas of the human large bowel. The expression of p21WAF1,CW1,SDI 1 was detected in 5 out of 15 adenomas (33.3 %) and in 13 out of 36 adenocarcinomas (36 %). Cdk1/p34cdc2 was expressed in 11 out of 15 adenomas (73.3%) and in 18 out of 36 adenocarcinomas (50%). In conclusion, our results indicate that there is an expression of cdk1/p34cdc2 in colorectal adenomas and absence of p21 WAF1,CIP1,SDI 1 in both colorectal adenomas and carcinomas. These results suggest that the proliferative activity of colonic cancer might not be solely dependent on control of the cell cycle by p21 WAF1,CIP1,SDI Cdk1/p34cdc2 expression, in a high percentage of both adenomas and adenocarcinomas suggest that this phenomenon may be an early event in colorectal carcinogenesis.
Egilmez
R
R
Dept. of Pathology, Faculty of Medicine, Mersin University, Turkey. hegilmez@e-kolay.net
Elagöz
S
S
Kanik
E A
EA
D000230:Adenocarcinoma / Q000378:metabolism*; D000236:Adenoma / Q000378:metabolism*; D016203:CDC2 Protein Kinase / Q000378:metabolism*; D003106:Colon / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000378:metabolism*; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D007413:Intestinal Mucosa / Q000378:metabolism
C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D016203:CDC2 Protein Kinase