Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking test.
A role for glucagon-like peptide-1 (GLP-1) has been postulated in the regulation of blood glucose and satiety. In addition, intracerebroventricular administration of GLP-1 has been shown to suppress locomotor activity, and produce a neuronal activation in the amygdala, a structure involved in mechanisms of fear and anxiety. Adult male Sprague-Dawley rats were prepared with chronic intracerebroventricular cannulae. Measures of experimental anxiety were assessed by the Vogel conflict test and the elevated plus maze. Central GLP-1 (fragment 7-36) administration produces a proconflict effect in the punished drinking test, while leaving measures of activity and nociception unaffected. GLP-1 may participate in the control of fear-induced suppression of behavior, probably via action in the amygdala.
Möller
Christian
C
Department of Neurotec, Karolinska Institutet, Stockholm, Sweden.
Sommer
Wolfgang
W
Thorsell
Annika
A
Rimondini
Roberto
R
Heilig
Markus
M
D000679:Amygdala / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000503:physiopathology*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology; D003220:Conflict, Psychological; D004327:Drinking Behavior / Q000187:drug effects*; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology*; D052216:Glucagon-Like Peptide 1; D004763:Glucagon-Like Peptides; D007263:Infusions, Parenteral; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011498:Protein Precursors / Q000008:administration & dosage / Q000494:pharmacology*; D011678:Punishment; D051381:Rats; D017207:Rats, Sprague-Dawley
D010446:Peptide Fragments; D011498:Protein Precursors; C055453:glucagon-like peptide 1 (7-36)amide; D004763:Glucagon-Like Peptides; D052216:Glucagon-Like Peptide 1; D005934:Glucagon