Torsade de pointes induced by metoclopramide in an elderly woman with preexisting complete left bundle branch block.
There is a growing list of drugs implicated in acquired long QT syndrome and torsade de pointes. However, the torsadogenic potential of metoclopramide, a commonly used antiemetic and prokinetic drug, has not been reported in the literature, despite its chemical similarity to procainamide. We report on a 92-year-old woman with preexisting complete left bundle branch block who developed torsade de pointes after intravenous and oral administration of metoclopramide. This patient also developed torsade de pointes when cisapride and erythromycin were given simultaneously. These two episodes were suppressed successfully after discontinuing the offending drugs and administering class IB drugs. This is the first documentation that metoclopramide provokes torsade de pointes clinically. Metoclopramide should be used cautiously in patients with a risk of torsade de pointes.
Chou
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CC
Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Chang Gung University College of Medicine, Taiwan, ROC. cc520@cgmh.org.tw
Wu
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D
D000368:Aged; D000369:Aged, 80 and over; D002037:Bundle-Branch Block / Q000150:complications*; D018492:Dopamine Antagonists / Q000009:adverse effects*; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000009:adverse effects*; D016171:Torsades de Pointes / Q000139:chemically induced*
D018492:Dopamine Antagonists; D008787:Metoclopramide