Ontogeny and genetics of the hemato/lymphopoietic system.
During embryogenesis there is a sequential, temporal appearance of increasingly more-complex hematopoietic cells beginning with unipotential progenitors, proceeding to multipotential (myeloid, erythroid and lymphoid) progenitors and culminating with adult-repopulating hematopoietic stem cells. Current research has established an important role for the aorta-gonads-mesonephros region of the mouse embryo in the generation of multipotential progenitors and hematopoietic stem cells. Comparisons of normal and hematopoietic-cell-mutant mouse embryos have revealed several genes pivotal in hematopoietic stem cell generation/function. Other genes have been implicated in the critical generation of lymphoid lineage potential. Thus, an understanding of the cellular and molecular interactions within the midgestation aorta-gonads-mesonephros region offers insight into the mechanisms of hematopoietic lineage specification during ontogeny and perhaps will lead to a more complete knowledge of the adult hematopoietic system.
Ling
Kam-Wing
KW
Department of Cell Biology and Genetics, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands.
Dzierzak
Elaine
E
D000818:Animals; D001011:Aorta / Q000166:cytology / Q000196:embryology; D002454:Cell Differentiation; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins / Q000502:physiology; D006066:Gonads / Q000166:cytology / Q000196:embryology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology; D006413:Hematopoietic System / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D051740:Ikaros Transcription Factor; D008221:Lymphoid Tissue / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D008650:Mesonephros / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D051379:Mice; D009024:Morphogenesis; D009154:Mutation; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors / Q000502:physiology; D015017:Yolk Sac / Q000196:embryology / Q000502:physiology
D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; C497238:Zfpn1a1 protein, mouse; D051740:Ikaros Transcription Factor