title: Antidiarrhoeal activity of Strychnos potatorum seed extract in rats.
abstract: The antidiarrhoeal activity of the methanol extract of the dried seeds of Strychnos potatorum (MESP) has been evaluated out in rats using different models (castor oil-induced diarrhoea, effects on gastrointestinal motility and on PGE(2)-induced gastric enteropooling. MESP (100, 200 and 400 mg/kg, p.o.) significantly (P<0.001) inhibited the frequency of defaecation and reduced the wetness of faecal droppings in castor oil-induced diarrhoea, decreased the propulsion of charcoal meal through the gastrointestinal tract, and also reduced the PGE(2)-induced enteropooling.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadavpur University, Calcutta 700 032, India.
authors.forename: Swati
authors.initials: S
authors.lastname: Biswas
authors.forename: T
authors.initials: T
authors.lastname: Murugesan
authors.forename: Sanghamitra
authors.initials: S
authors.lastname: Sinha
authors.forename: Kuntal
authors.initials: K
authors.lastname: Maiti
authors.forename: Jiaur Rahaman
authors.initials: JR
authors.lastname: Gayen
authors.forename: M
authors.initials: M
authors.lastname: Pal
authors.forename: B P
authors.initials: BP
authors.lastname: Saha
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003968:Diarrhea, Infantile / Q000188:drug therapy*; D015232:Dinoprostone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D029541:Loganiaceae; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds
chemical_list: D000930:Antidiarrheals; D010936:Plant Extracts; D015232:Dinoprostone