title: [The combination of cyclosporin A and androgen in the treatment of chronic aplastic anemia].
abstract: OBJECTIVE
  To explore the therapeutic effectiveness of combination of cyclosporin A (CsA) and androgen in the treatment of chronic aplastic anemia (CAA).
  
  
  METHODS
  Androgen alone or combined with CsA for the treatment of CAA was compared by a randomized controlled clinical trial.
  
  
  RESULTS
  The efficacy of androgen combined with CsA (87.9%) was higher than that of androgen alone (57.1%). Therapeutic effectiveness of the combination treatment between the patients with positive and negative peripheral blood mononuclear cells (PBMNCs) inhibiting normal colony formation unit-granulocyte and macrophage (CFU-GM) test showed a significant difference (P < 0.005).
  
  
  CONCLUSIONS
  Androgen combined with CsA had a much better efficacy than that of androgen alone in the treatment of CAA. The patients' PBMNCs inhibiting normal CFU-GM growth test can be used as an index of the treatment outcome. The side effects of the combination therapy are low and tolerable.
authors.affiliation: Department of Hematology, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310006, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: R
authors.initials: R
authors.lastname: Yu
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
authors.forename: N
authors.initials: N
authors.lastname: Zhu
authors.forename: S
authors.initials: S
authors.lastname: Lin
authors.forename: X
authors.initials: X
authors.lastname: Luo
authors.forename: R
authors.initials: R
authors.lastname: Gao
authors.forename: J
authors.initials: J
authors.lastname: Jin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000728:Androgens / Q000627:therapeutic use*; D000741:Anemia, Aplastic / Q000097:blood / Q000188:drug therapy*; D001772:Blood Cell Count; D002648:Child; D002908:Chronic Disease; D016572:Cyclosporine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000728:Androgens; D016572:Cyclosporine