Antigen-dependent B-cell development.
There is growing evidence that the development of naïve B cells depends on the interaction of self antigens with the BCR. A view that has emerged over the past year is that BCR signal output contributes in a large part to the developmental fate of peripheral B cells. Differences in antigen-receptor signal strength may determine whether B cells assume a marginal zone, follicular or B-1 phenotype.
Cariappa
Annaiah
A
Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.
Pillai
Shiv
S
D000818:Animals; D001324:Autoantigens / Q000502:physiology*; D001402:B-Lymphocytes / Q000502:physiology*; D001853:Bone Marrow / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology*; D006801:Humans; D013154:Spleen / Q000502:physiology
D001324:Autoantigens