Critical involvement of CD40 in protection against herpes simplex virus infection in a murine model of genital herpes.
We studied the requirement for CD40+ cells in the resolution of vaginal infection with avirulent herpes simplex virus type I (HSV-1) in vivo using CD40-deficient mice, which were susceptible to infection with avirulent HSV-1. Compared with wild-type mice, CD40-deficient mice could not eliminate HSV-1 virus effectively from the vaginal mucosa and produced lower amounts of interleukin-12 and interferon-gamma. These results show that the induction and activation of CD40+ cells are important for HSV prevention, facilitating the activation of T cells to induce an efficient HSV clearance from the vaginal mucosa and to prevent lethal illness due to HSV infection.
Inagaki-Ohara
K
K
Laboratory of Virology, Research Institute for Disease Mechanism and Control, Nagoya, Japan.
Kawabe
T
T
Hasegawa
Y
Y
Hashimoto
N
N
Nishiyama
Y
Y
D000818:Animals; D019013:CD40 Antigens / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis; D004195:Disease Models, Animal; D005260:Female; D006558:Herpes Genitalis / Q000276:immunology* / Q000503:physiopathology / Q000517:prevention & control / Q000821:virology; D018259:Herpesvirus 1, Human / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology; D014621:Vagina / Q000821:virology; D014623:Vaginal Diseases / Q000276:immunology* / Q000503:physiopathology / Q000517:prevention & control / Q000821:virology
D019013:CD40 Antigens; D016207:Cytokines