title: Combinatorial approaches to inhibitors of VLA-4: piperazine-peptoid-bisarylureas.
abstract: A combinatorial approach towards identifying inhibitors of VALA-4 was investigated. A library of piperazine-peptoid-bisarylureas was assembled in solid phase and screening in the novel v-well assay enabled the identification of active compounds.
authors.affiliation: Transplantation Research Chemistry Unit, S-507.3.03, Novartis Pharma, CH-4002 Basel, Switzerland. ian.lewis@pharma.novartis.com
authors.forename: I
authors.initials: I
authors.lastname: Lewis
authors.forename: B
authors.initials: B
authors.lastname: Rohde
authors.forename: M
authors.initials: M
authors.lastname: Mengus
authors.forename: M
authors.initials: M
authors.lastname: Weetall
authors.forename: S
authors.initials: S
authors.lastname: Maida
authors.forename: R
authors.initials: R
authors.lastname: Hugo
authors.forename: P
authors.initials: P
authors.lastname: Lake
mesh_terms: D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques; D019992:Databases as Topic; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004126:Dimethylformamide / Q000737:chemistry; D039041:Integrin alpha4beta1; D016023:Integrins / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D013058:Mass Spectrometry; D008956:Models, Chemical; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D034444:Peptoids; D000077489:Piperazine; D010879:Piperazines / Q000494:pharmacology*; D016201:Receptors, Lymphocyte Homing / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D012984:Software; D014230:Triazoles / Q000737:chemistry
chemical_list: D039041:Integrin alpha4beta1; D016023:Integrins; D019151:Peptide Library; D010455:Peptides; D034444:Peptoids; D010879:Piperazines; D016201:Receptors, Lymphocyte Homing; D014230:Triazoles; D000077489:Piperazine; D004126:Dimethylformamide; C011852:1-hydroxybenzotriazole; D004121:Dimethyl Sulfoxide