[Effect of plant melanin pigment on the clastogenic effects of chemical mutagens in mice].
The chromosome aberration assay in the bone marrow cells of C57BL/6 mice showed that melanin pigment (MP) in a dose range from 0.01 to 10 mg/kg does not influence the clastogenic effect of dioxidine (200 mg/kg, i.p.), while reducing the clastogenic effect of cyclophosphamide (20 mg/kg, i.p.) by a factor of 1.5-4 in various treatment regimes depending on the mutagen injection time.
Alekseeva
T N
TN
Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Durnev
A D
AD
Kulakova
A V
AV
Oreshchenko
A V
AV
Samusenok
L V
LV
Ogarkov
B N
BN
Seredenin
S B
SB
D000818:Animals; D016587:Antimutagenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D008297:Male; D008543:Melanins / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011810:Quinoxalines / Q000633:toxicity
D016587:Antimutagenic Agents; D008543:Melanins; D009153:Mutagens; D010936:Plant Extracts; D011810:Quinoxalines; C001077:dioxidine; D003520:Cyclophosphamide