Islet immunoisolation: experience with biopolymers.
Incidence of Type I diabetes is increasing globally and has become a major health concern. There is enough evidence suggesting involvement of autoimmunity in destruction of insulin-producing islets of langerhans which leads to impaired glucose homeostasis. Islet transplantation is one of the approaches that received wide attention. Due to the autoimmune nature of the disease. strategies to protect transplanted islet graft from rejection are sought. Immunoisolation of islets inside semipermeable biocompatible materials is amongst them. Natural biopolymers have been used extensively as immunoisolation materials due to their satisfactory biocompatiblity and tissue tolerance. Here we attempt to address the need for islet immunoisolation and our experience in using natural biopolymers such as chitosan, cellulose and alginate for this application.
Risbud
M V
MV
Tissue Engineering and Banking Laboratory, National Centre for Cell Sciences, Ganeshkhind, Pune, India. mrisbud@hotmail.com
Bhonde
R R
RR
D000464:Alginates / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001704:Biopolymers / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry; D002686:Chitin / Q000031:analogs & derivatives / Q000737:chemistry; D048271:Chitosan; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000628:therapy; D006648:Histocompatibility; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007515:Islets of Langerhans / Q000166:cytology*; D016381:Islets of Langerhans Transplantation; D051379:Mice; D008863:Microspheres; D008956:Models, Chemical; D011108:Polymers / Q000737:chemistry
D000464:Alginates; D001672:Biocompatible Materials; D001704:Biopolymers; D011108:Polymers; D002686:Chitin; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D002482:Cellulose; D048271:Chitosan