Primary epithelioid sarcoma of the dura: case report.
OBJECTIVE
Epithelioid sarcomas are rare mesenchymal neoplasms that occur most often in the extremities of young adults. Despite isolated reports of epithelioid sarcomas arising in the head and neck region, these lesions have not been described previously, to our knowledge, in the central nervous system.


METHODS
We present the case of an 18-year-old woman with a unique dural sarcoma that arose in the right frontotemporal region. As visualized on magnetic resonance imaging studies, the 4.5-cm tumor focally traversed the cranium to penetrate the galea, the temporal muscle, and subcutaneous tissue. No brain invasion was noted.


METHODS
Despite gross total removal and postoperative radiotherapy (59 Gy), a large recurrence was noted 5 months after surgery. Histologically, the partly necrotic tumor consisted of epithelioid and spindle cells showing widespread vimentin and variable cytokeratin as well as epithelial membrane antigen immunoreactivity. Ultrastructurally, the cohesive cells featured various organelles, intermediate filaments, junctions, and filopodia-containing intercellular spaces.


CONCLUSIONS
With the inclusion of epithelioid sarcoma, the spectrum of central nervous system sarcomas continues to expand.
Kurtkaya-Yapícíer
Ozlem
O
Department of Pathology, Institute of Neurological Sciences, Marmara University, Istanbul, Turkey.
Scheithauer
Bernd W
BW
Dedrick
David J
DJ
Wascher
Thomas M
TM
D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D004388:Dura Mater / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor