Application of the "VARICOL" process to the separation of the isomers of the SB-553261 racemate.
A new continuous chromatographic process (VARICOL) has been presented recently. The basic principle of the new VARICOL process consists of an asynchronous shift of the inlet/outlet lines in a multi-column system on a recycle loop. This process has been used to perform the separation of the optical isomers of the SB-553261 racemate. In this paper, we illustrate that for this specific separation, the VARICOL process is more efficient than the well-known SMB process.
Ludemann-Hombourger
O
O
NOVASEP SAS, Site Eiffel, Pompey, France. olivier_ludemann-hombourger@novasep.com
Pigorini
G
G
Nicoud
R M
RM
Ross
D S
DS
Terfloth
G
G
D002845:Chromatography / Q000295:instrumentation / Q000379:methods*; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry*; D013237:Stereoisomerism
D006574:Heterocyclic Compounds, 2-Ring; C464580:SB-553261