Water intake and 24-hour blood pressure monitoring in a patient with nephrogenic diabetes insipidus caused by a novel mutation of the vasopressin V2R gene.
A 47-year-old man presented with polydipsia, which had had since childhood, and recent onset of hypertension. Genetic analysis proved that he had nephrogenic diabetes insipidus caused by a novel mutation (deletion of 6 amino acids between G107 and C112) in the vasopressin V2 receptor gene. Results of 24-hour blood pressure monitoring disclosed a greater dipping pattern and greater blood pressure variability during waking hours than in male patients with only essential hypertension. This characteristic blood pressure profile may result from daily occurrence of free water depletion, as further observation indicated that water deprivation was associated with a reduction in blood pressure.
Owada
Masahiko
M
Second Department of Internal Medicine, Iwate Medical University, Morioka.
Kawamura
Minoru
M
Kimura
Yasukazu
Y
Fujiwara
Takuya
T
Uchida
Shinichi
S
Sasaki
Sei
S
Hiramori
Katsuhiko
K
D001127:Arginine Vasopressin / Q000097:blood; D018660:Blood Pressure Monitoring, Ambulatory; D004252:DNA Mutational Analysis; D018500:Diabetes Insipidus, Nephrogenic / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D004326:Drinking; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D016133:Polymerase Chain Reaction; D017483:Receptors, Vasopressin / Q000235:genetics*; D017384:Sequence Deletion; D014868:Water Deprivation
D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin