[New data concerning the significance of immunoglobulins and B cells in the pathogenesis of multiple sclerosis].
Contemporary studies concerning the significance of immunoglobulins in the mechanism of multiple sclerosis are based on the analysis on the genome level. It was found that genes encoding immunoglobulins are restricted to active gene segments and showed a great frequency of mutations in sequences encoding the complementarity-determining regions (CDR s). The above presented results led to the conclusion, that synthesis of immunoglobulins and activation of B cells are not only the result of nonspecific reaction but are the antigen-driven response, related to the immunological mechanism of the disease.
Wender
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D000951:Antigens, Neoplasm; D001402:B-Lymphocytes / Q000276:immunology*; D015815:Cell Adhesion Molecules; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology* / Q000378:metabolism; D018992:Myelin-Associated Glycoprotein / Q000378:metabolism
D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D018992:Myelin-Associated Glycoprotein