[Study of platelet membrane glycoproteins and its fibrinogen binding reaction in patients with cerebral infarction and diabetes mellitus].
OBJECTIVE
To investigate the change of platelet membrane glycoproteins and its fibrinogen binding reaction in patients with cerebral infarction and type II diabetes mellitus (DM), and assess their value in the study of thrombosis and pro-thrombosis state.


METHODS
By flow cytometry, the platelet glycoprotein (GP) I b, GP II b, GP III a, GP II b- III a complex and P-selectin expression as well as fibrinogen binding reaction were analyzed in 85 patients with type II DM and 28 with cerebral infarction, and compared with that in 30 normal subjects.


RESULTS
The platelet membrane GP II b- III a complex, P-selectin expression and fibrinogen binding reaction were higher, while the platelet surface GP I b was lower in the patients with cerebral infarction and type II DM with vascular disease than those in normal group. The GP II b and GP III a were not significantly changed. There was no difference of these parameters between the type II DM without vascular disease patients and normal group.


CONCLUSIONS
The platelet fibrinogen binding reaction, P-selectin and GP II b- III a complex expression were increased while the GP I b decreased in patients with cerebral infarction and type II DM with vascular disease.
Han
Y
Y
Jiangsu Institute of Hematology, The First Affiliated Hospital of Suzhou Medical College, Suzhou 215006, China.
Wang
Z
Z
Zhu
M
M
Wang
A
A
Bai
X
X
Ruan
C
C
D000328:Adult; D000368:Aged; D002544:Cerebral Infarction / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005434:Flow Cytometry; D006801:Humans; D039661:Integrin beta3 / Q000032:analysis; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000032:analysis; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000032:analysis; D040201:Platelet Membrane Glycoprotein IIb / Q000032:analysis; D010980:Platelet Membrane Glycoproteins / Q000032:analysis*
D039661:Integrin beta3; D019007:P-Selectin; D019038:Platelet Glycoprotein GPIb-IX Complex; D040201:Platelet Membrane Glycoprotein IIb; D010980:Platelet Membrane Glycoproteins; D005340:Fibrinogen