Effect of peroxidase in complex with basic antileprosy drugs on liver, blood, and functional activity of phagocytes in mice with experimental leprosy.
Therapeutic effect of lyophilized horseradish peroxidase in complex with the basic antileprosy drugs diaminodiphenylsulfone and rifampicin was studied in experimental leprosy. Oral therapy with drug complexes was more effective than monotherapy. Treatment with drug combinations activated myeloperoxidase in blood neutrophil, produced an antiinflammatory effect, stimulated cell immunity, and had no toxic effect on mouse liver.
Maslov
A K
AK
Institute of Leprosy, Ministry of Health of Russian Federation, Astrakhan. niil@astmail.astranet.ru
Luzhnova
S A
SA
Kalyanina
O V
OV
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D003622:Dapsone / Q000494:pharmacology; D004338:Drug Combinations; D006735:Horseradish Peroxidase / Q000378:metabolism; D007917:Leprostatic Agents / Q000494:pharmacology*; D007918:Leprosy / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D009504:Neutrophils / Q000187:drug effects; D009195:Peroxidase / Q000494:pharmacology*; D010586:Phagocytes / Q000187:drug effects*; D012293:Rifampin / Q000494:pharmacology; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D007917:Leprostatic Agents; D003622:Dapsone; D006735:Horseradish Peroxidase; D009195:Peroxidase; D012293:Rifampin