title: A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection.
abstract: The immunogenicity and protective efficacy of overlapping regions of the protective antigen (PA) polypeptide, cloned and expressed as glutathione S-transferase fusion proteins, have been assessed. Results show that protection can be attributed to individual domains and imply that it is domain 4 which contains the dominant protective epitopes of PA.
authors.affiliation: Dstl, Chemical and Biological Sciences, Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom.
authors.forename: Helen C
authors.initials: HC
authors.lastname: Flick-Smith
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Walker
authors.forename: Paula
authors.initials: P
authors.lastname: Gibson
authors.forename: Helen
authors.initials: H
authors.lastname: Bullifent
authors.forename: Sarah
authors.initials: S
authors.lastname: Hayward
authors.forename: Julie
authors.initials: J
authors.lastname: Miller
authors.forename: Richard W
authors.initials: RW
authors.lastname: Titball
authors.forename: E Diane
authors.initials: ED
authors.lastname: Williamson
mesh_terms: D000818:Animals; D000881:Anthrax / Q000401:mortality / Q000517:prevention & control*; D022122:Anthrax Vaccines / Q000276:immunology*; D000942:Antigens, Bacterial; D001427:Bacterial Toxins / Q000276:immunology*; D005260:Female; D051379:Mice; D010446:Peptide Fragments / Q000276:immunology; D017434:Protein Structure, Tertiary; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D022122:Anthrax Vaccines; D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D010446:Peptide Fragments; D014614:Vaccines, Synthetic; C030325:anthrax toxin