title: Power and replication in case-control studies.
abstract: The case-control study design, a common staple of epidemiology, is increasingly used to test for genetic association. The simplicity of the design accounts for both its appeal and its limitations. Too often, however, apparent controversy arises for lack of appreciation of basic tenets underlying statistical testing. Power and replication are two concepts most commonly ignored in evaluating such studies. We review the basic principles of statistical testing, recall simple means to calculate power, and provide numerical examples pertaining to the association between angiotensinogen and essential hypertension.
authors.affiliation: Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, USA. jml@howard.genetics.utah.edu
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Lalouel
authors.forename: Andreas
authors.initials: A
authors.lastname: Rohrwasser
mesh_terms: D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics; D016022:Case-Control Studies; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics; D013223:Statistics as Topic
chemical_list: D000808:Angiotensinogen