[Effect of nootropic agents on impulse activity of cerebral cortex neurons].
The effect of nootropes (semax, mexidol, and GVS-111) on the activity of individual neurons in various cerebral cortex regions was studied by microelectrode and microionophoresis techniques in cats immobilized by myorelaxants. It was established that the inhibiting effect of mexidol upon neurons in more than half of cases is prevented or significantly decreased by the GABA antagonists bicuculline and picrotoxin. The inhibiting effect of semax and GVS-111 upon neurons in more than half of cases is related to stimulation of the M-choline and NMDA receptors, respectively.
Iasnetsov
V V
VV
Department of Pharmacology, Gidrobios Research and Production Center, Ministry of Public Health of the Russian Federation, ul. Kosmonavtov 18 (korp. 2), Moscow, 129301 Russia.
Pravdivtsev
V A
VA
Krylova
I N
IN
Kozlov
S B
SB
Provornova
N A
NA
Ivanov
Iu V
IuV
Iasnetsov
V V
VV
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002415:Cats; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D004151:Dipeptides / Q000494:pharmacology; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018697:Nootropic Agents / Q000494:pharmacology*; D010847:Picolines / Q000494:pharmacology*; D010852:Picrotoxin / Q000494:pharmacology; D018079:Receptors, GABA / Q000187:drug effects
D001640:Bicuculline; D004151:Dipeptides; D018697:Nootropic Agents; D010847:Picolines; D010852:Picrotoxin; D018079:Receptors, GABA; C070020:emoxypine succinate; C103871:ethyl phenylacetyl-Pro-Gly