title: Assamicin I and II, novel triterpenoid saponins with insulin-like activity from Aesculus assamica Griff.
abstract: Two novel triterpenoid saponins with insulin-like activity, termed assamicin I and II, were isolated from the roots of Aesculus assamica Griff. and their structures were characterized as 1 and 2, respectively. They inhibited release of free fatty acids from epinephrine-treated rat adipocytes and enhanced glucose uptake into 3T3-L1 adipocytes.
authors.affiliation: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakurai
authors.forename: Toshio
authors.initials: T
authors.lastname: Nishimura
authors.forename: Noboru
authors.initials: N
authors.lastname: Otake
authors.forename: Yao
authors.initials: Y
authors.lastname: Xinsheng
authors.forename: Keiichi
authors.initials: K
authors.lastname: Abe
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Zeida
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Nagasawa
authors.forename: Shohei
authors.initials: S
authors.lastname: Sakuda
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D051379:Mice; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D012503:Saponins; C461196:assamicin I; C461197:assamicin II; D005947:Glucose; D004837:Epinephrine