Genetic basis of glaucoma.
The application of molecular genetic techniques to the study of glaucoma has accelerated greatly during the past few years. In addition to localizing and identifying genes for specific types of glaucoma, researchers have begun to characterize the gene products and investigate molecular mechanisms involved in glaucoma. Much research has been focused on the gene expression, protein processing, and mutations of MYOC/TIGR, which is associated with both juvenile-and adult-onset primary open angle glaucoma. Investigations of other glaucoma-related genes, such as PITX2, FOXC1, and CYP1B1, are enabling a better understanding of anterior segment development and its relation to glaucoma.
WuDunn
Darrell
D
Department of Ophthalmology, Indiana University, Indianapolis, Indiana 46202, USA. dwudunn@iupui.edu
D001189:Aryl Hydrocarbon Hydroxylases; D065633:Cytochrome P-450 CYP1B1; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D005136:Eye Proteins / Q000235:genetics; D051858:Forkhead Transcription Factors; D005821:Genetic Techniques; D005901:Glaucoma / Q000235:genetics*; D006023:Glycoproteins / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D008967:Molecular Biology; D009687:Nuclear Proteins; D014157:Transcription Factors / Q000235:genetics; D000097577:Homeobox Protein PITX2; D000099179:Myocilin
D001189:Aryl Hydrocarbon Hydroxylases; D065633:Cytochrome P-450 CYP1B1; D003577:Cytochrome P-450 Enzyme System; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D005136:Eye Proteins; D051858:Forkhead Transcription Factors; D006023:Glycoproteins; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; D000097577:Homeobox Protein PITX2; D000099179:Myocilin; C112743:FOXC1 protein, human; C585496:CYP1B1 protein, human