title: [New approaches to analysis of the interrelationship between cholinergic and dopaminergic mediator systems].
abstract: Intermediatory relationships between the cholinergic and dopaminergic neurotransmission systems were analyzed using published data and the original experimental results obtained on Daphnia magna Straus, a new test object. Based on these results, the antihaloperidol activity of a series of M- cholinoblocking agents with different receptor selectivities were studied in comparison to the new cholinoblocker pentifin exceeding in the activity the classical antiparkinsonian drugs such as cyclodol, amedin, and norakin.
authors.affiliation: Institute of Toxicology, Ministry of Public Health of the Russian Federation, ul. Bekhtereva 1, St. Petersburg, 193019 Russia.
authors.forename: N P
authors.initials: NP
authors.lastname: Podosinovikova
authors.forename: A B
authors.initials: AB
authors.lastname: Kosmachev
authors.forename: V D
authors.initials: VD
authors.lastname: Tonkopiĭ
authors.forename: A O
authors.initials: AO
authors.lastname: Zagrebin
authors.forename: E A
authors.initials: EA
authors.lastname: Evdokimova
authors.forename: A M
authors.initials: AM
authors.lastname: Maslov
authors.forename: V V
authors.initials: VV
authors.lastname: Petrov
authors.forename: V B
authors.initials: VB
authors.lastname: Dolgo-Saburov
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology; D003621:Daphnia; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D000978:Antiparkinson Agents; D018680:Cholinergic Antagonists; D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine