["Augmentin" in the antibiotic prevention of postoperative infections complications in gynecological cancer patients].
Hysterectomies are arbitrarily pure operations and thus require antibiotic prevention. A great risk for postoperative infections is particularly high after Wertheim's operation. This study evaluated the efficiency of infection prevention in 19 cancer gynecological patients by using the antibiotic augmentin (amoxicillin/clavulanic acid). The first dose was administered 30 minutes before surgery in order to achieve the maximum drug concentration in blood and tissue at surgery. There was no wound suppuration. One patient (5.3%) undergone Werthein's operation was diagnosed to have retroperitoneal hematoma suppuration. One more patient (5.3%) had fever of unknown genesis. Urinary infections that are not considered to be a sign of inefficiency of antibiotic prevention and that were due to long-term catheter placement developed in 4 (21.1%) of the 19 patients. The postoperative period was smooth in 14 (73.7%) of the 19 patients. The perioperative Augumentin administration regimen used by the authors was easy-to-use and beneficial and the drug shows a low toxicity so it may be used for antibiotic prevention in cancer gynecological patients.
Petukhova
I N
IN
Nummaev
B G
BG
Sokolova
E N
EN
Dmitrieva
N V
NV
Kuznetsov
V V
VV
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D005833:Genital Neoplasms, Female / Q000601:surgery*; D006801:Humans; D013530:Surgical Wound Infection / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination