[Seasonal features of the effect of adaptogens on sex behavior of experimental animals].
Seasonal variation of the aphrodiatical activity of pantocrin (deer antler extract), ginseng root tincture, and eleuterococcus extract was studied. It was found that a one-month treatment with these adaptogen preparations in a daily dose of 100 mg/kg (for dry parent substance) stimulate the sexual behavior of puberal mice and rat males in winter. The maximum effect was observed for pantocrin. In summer months, the stimulating effect of adaptogens was not manifested. The reference drug (tentex forte) increased the sexual behavior irrespective of the season, the effect being more pronounced in summer months. These results are explained by assuming that the adaptogens studied possess a weak gonadotropic activity, which favors normalization of the testosterone level (reduced in winter season) in experimental animals.
Kropotov
A V
AV
Pharmacology Department, Vladivostok State Medical University, Prospekt Ostryakova 2, Vladivostok, 690002 Russia.
Lisakovskaia
O V
OV
Khotimchenko
Iu S
IuS
D000818:Animals; D000999:Antlers / Q000737:chemistry; D003670:Deer; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D012621:Seasons; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts