Antibiotic-resistant enterococci: the mechanisms and dynamics of drug introduction and resistance.
Enterococci possess a vast array of mechanisms to resist the lethal effects of most antimicrobial drugs currently approved for therapeutic use in humans, thus presenting a considerable therapeutic challenge. This review summarizes current concepts regarding the mechanisms of resistance, as well as the emergence, proliferation, and epidemiology of resistant enterococci.
Shepard
Brett D
BD
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 975 NE 10th St., BRC 356, Oklahoma City, Oklahoma, USA.
Gilmore
Michael S
MS
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004197:Disease Reservoirs; D024901:Drug Resistance, Multiple, Bacterial; D016983:Enterococcus / Q000187:drug effects* / Q000502:physiology; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D015995:Prevalence
D000900:Anti-Bacterial Agents