title: Do interleukin-1 polymorphisms predict the development of periodontitis or the success of dental implants?
abstract: Factors which increase the risk of severe adult periodontitis (AP) may also contribute to the success of dental implants. To determine which cytokines may be relevant, levels of interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta), interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6) and interferon-gamma (IFN-gamma) mRNA were quantitated in gingival tissue from periodontitis patients and healthy controls. Periodontitis significantly increased levels of IL-1alpha, IL-1beta, IL-6 and IFN-gamma mRNA relative to healthy tissues. IL-1 was selected for further study, as it has inflammatory and bone resorbing properties. We examined IL-1A(-889) and IL-1B(+3953) alleles in Caucasian patients with AP and early-onset periodontitis (EOP), patients with dental implants and healthy individuals. The IL-1B(+3953) polymorphism was associated with AP. This was evident from an increased homozygosity for allele 2 in patients with AP and a decreased heterozygosity in advanced AP patients. IL-1A(-889) and a composite genotype [IL-1A(-889)2 plus IL-1B(+3953)2] showed no association with the incidence of periodontitis, disease onset or disease severity. IL-1A(-889), IL-1B(+3953) and the composite genotype also showed no association with failure of dental implants.
authors.affiliation: Department of Pathology, University of Western Australia, Perth, Australia.
authors.forename: Marina A
authors.initials: MA
authors.lastname: Rogers
authors.forename: Lisa
authors.initials: L
authors.lastname: Figliomeni
authors.forename: Katarina
authors.initials: K
authors.lastname: Baluchova
authors.forename: Albert E S
authors.initials: AE
authors.lastname: Tan
authors.forename: Gareth
authors.initials: G
authors.lastname: Davies
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Henry
authors.forename: Patricia
authors.initials: P
authors.lastname: Price
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D010520:Aggressive Periodontitis / Q000235:genetics / Q000276:immunology; D000483:Alleles; D016022:Case-Control Studies; D015921:Dental Implants; D019232:Dental Restoration Failure; D005260:Female; D005544:Forecasting; D005838:Genotype; D005881:Gingiva / Q000737:chemistry; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000235:genetics*; D015850:Interleukin-6 / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D011110:Polymorphism, Genetic / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors; D012307:Risk Factors; D012795:Sialoglycoproteins / Q000032:analysis; D016896:Treatment Outcome
chemical_list: D015921:Dental Implants; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D015850:Interleukin-6; D012333:RNA, Messenger; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; D007371:Interferon-gamma