title: CJ-15,801, a novel antibiotic from a fungus, Seimatosporium sp.
abstract: A novel antibiotic, CJ-15,801 (I), was isolated from the fermentation broth of a fungus, Seimatosporium sp. CL28611. The structure was determined to be a pantothenic acid analog having an alpha,beta-unsaturated carboxylic acid moiety by spectroscopic analyses. The compound inhibits the growth of multi-drug resistant (MDR) Staphylococcus aureus strains with MIC ranging from 6.25 to 50 microg/ml.
authors.affiliation: Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. Yutaka.Sugie@japan.pfizer.com
authors.forename: Y
authors.initials: Y
authors.lastname: Sugie
authors.forename: K A
authors.initials: KA
authors.lastname: Dekker
authors.forename: H
authors.initials: H
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Ichiba
authors.forename: M
authors.initials: M
authors.lastname: Ishiguro
authors.forename: Y
authors.initials: Y
authors.lastname: Shiomi
authors.forename: A
authors.initials: A
authors.lastname: Sugiura
authors.forename: L
authors.initials: L
authors.lastname: Brennan
authors.forename: J
authors.initials: J
authors.lastname: Duignan
authors.forename: L H
authors.initials: LH
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Sutcliffe
authors.forename: Y
authors.initials: Y
authors.lastname: Kojima
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D010205:Pantothenic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; C449028:CJ-15,801; D010205:Pantothenic Acid