[Endocrine disruptors and nuclear receptors].
Endocrine dirsuptors are supposed to modulate function of nuclear receptors by binding their ligand-binding domain. As nuclear receptors are ligand dependent transcription factor, endocrine disruptors function as agonist or antagonist. Although actual mechanism of endocrine disruption is not well understood, several nuclear receptors are reported as targets of endocrine disruptors. In this review, the functions of nuclear receptors suspected as targets of endocrine disruptors are described.
Watanabe
Hajime
H
Okazaki National Research Institutes, National Institute for Basic Biology, CREST, JST.
Iguchi
Taisen
T
Morohashi
Ken-ichiro
K
D000818:Animals; D004785:Environmental Pollutants / Q000009:adverse effects*; D006801:Humans; D011944:Receptors, Androgen / Q000187:drug effects; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects*; D011960:Receptors, Estrogen / Q000187:drug effects*
D004785:Environmental Pollutants; D011944:Receptors, Androgen; D018160:Receptors, Cytoplasmic and Nuclear; D011960:Receptors, Estrogen