title: [Big endothelin and chronic heart failure].
abstract: In a group of 124 patients the authors investigated the importance of assessment of plasma levels of big endothelin and endothelin 1 in patients with chronic heart failure as compared with other currently used non-invasive parameters. A six fold increase of plasma levels of both substances was found in patients in functional class NYHA IV as compared with patients in class NYHA II-III. But even patients in the milder stage of NYHA had twice as high values as compared with the standard of the healthy population. Similarly patients with interstitial pulmonary oedema had a twice as high level of both parameters as compared with patients who had a normal finding on X-ray or merely a redistribution of the pulmonary vascularization. The sensitivity of assessment of plasma levels is such that this examination could become part of the basic diagnosis.
authors.affiliation: II. interní klinika FN u sv. Anny, Brno.
authors.forename: J
authors.initials: J
authors.lastname: Spinar
authors.forename: L
authors.initials: L
authors.lastname: Spinarová
authors.forename: J
authors.initials: J
authors.lastname: Vítovec
authors.forename: O
authors.initials: O
authors.lastname: Ludka
authors.forename: G
authors.initials: G
authors.lastname: Hubená
authors.forename: M
authors.initials: M
authors.lastname: Tomandlová
authors.forename: J
authors.initials: J
authors.lastname: Tomandl
mesh_terms: D015415:Biomarkers / Q000097:blood; D019332:Endothelin-1 / Q000097:blood; D016232:Endothelins / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000097:blood*; D011654:Pulmonary Edema / Q000097:blood; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D016232:Endothelins; D011498:Protein Precursors