title: Increased antibody production by retinoids is related to the fusion partner of human hybridomas.
abstract: An increase of human monoclonal antibody production caused by retinyl acetate and retinoic acid was influenced by the fusion partner rather than the original B lymphocyte used for the human hybridoma generation. Retinoid response of human hybridomas may be at least related to retinoid X receptor-alpha gene expression, which seemed to originate from their fusion partner.
authors.affiliation: Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Japan. inoue@chem.agri.kagoshima-u.ac.jp
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Inoue
authors.forename: Sanetaka
authors.initials: S
authors.lastname: Shirahata
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D000912:Antibodies, Neoplasm / Q000096:biosynthesis*; D000917:Antibody Formation / Q000187:drug effects; D002459:Cell Fusion; D004224:Diterpenes; D015870:Gene Expression; D006801:Humans; D006825:Hybridomas; D008175:Lung Neoplasms / Q000276:immunology; D018168:Receptors, Retinoic Acid / Q000235:genetics; D000084562:Retinyl Esters; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D004224:Diterpenes; D018168:Receptors, Retinoic Acid; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D014212:Tretinoin