title: The Y chromosome effect on blood pressure in two European populations.
abstract: Higher blood pressure (BP) in males compared with females is well documented and is thought to be influenced in part by the Y chromosome. To examine whether there is an association between BP and a polymorphic HindIII biallelic marker in the nonrecombining region of the Y chromosome, we genotyped 155 males from a Polish study group and 762 males from a Scottish study group. We also tested for possible interaction between the Y chromosome and a mutation in the steroidogenic factor binding site of the aldosterone synthase gene by genotyping the same group from Scotland. There was no significant difference in age or body mass index between 2 Y chromosome genotypes in both study groups. Men with the HindIII(+) genotype had significantly higher systolic and diastolic pressures than those with the HindIII(-) genotype in both the Polish and Scottish studies. This difference between the genotypes was 5.27 mm Hg (P=0.0014) and 3.14 mm Hg (P=0.0005) for adjusted systolic BP and 2.6 mm Hg (P=0.0045) and 1.44 mm Hg (P=0.0084) for adjusted diastolic BP in the Polish and the Scottish studied, respectively. On binary logistic regression analysis, males with the HindIII(+)/TT SF1 genotype combination had an odds ratio for elevated BP of 3.92 (CI 1.21 to 12.68, P=0.023). Our results indicate that the Y chromosome harbors a locus or loci that contribute to BP variation in hypertensive and normotensive men. The polymorphism in the aldosterone synthase gene may interact with the Y chromosome to increase the odds of an individual's developing higher BP.
authors.affiliation: British Heart Foundation Blood Pressure Group, Department of Medicine, University of Glasgow, United Kingdom.
authors.forename: Fadi J
authors.initials: FJ
authors.lastname: Charchar
authors.forename: Maciej
authors.initials: M
authors.lastname: Tomaszewski
authors.forename: Sandosh
authors.initials: S
authors.lastname: Padmanabhan
authors.forename: Beata
authors.initials: B
authors.lastname: Lacka
authors.forename: Mark N
authors.initials: MN
authors.lastname: Upton
authors.forename: Gordon C
authors.initials: GC
authors.lastname: Inglis
authors.forename: Niall H
authors.initials: NH
authors.lastname: Anderson
authors.forename: Alex
authors.initials: A
authors.lastname: McConnachie
authors.forename: Ewa
authors.initials: E
authors.lastname: Zukowska-Szczechowska
authors.forename: Wladyslaw
authors.initials: W
authors.lastname: Grzeszczak
authors.forename: John M C
authors.initials: JM
authors.lastname: Connell
authors.forename: Graham C M
authors.initials: GC
authors.lastname: Watt
authors.forename: Anna F
authors.initials: AF
authors.lastname: Dominiczak
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000378:metabolism; D005060:Europe / Q000453:epidemiology; D005260:Female; D051717:Fushi Tarazu Transcription Factors; D005828:Genetics, Population; D018398:Homeodomain Proteins; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D018160:Receptors, Cytoplasmic and Nuclear; D012737:Sex Factors; D054339:Steroidogenic Factor 1; D014157:Transcription Factors / Q000378:metabolism; D014998:Y Chromosome
chemical_list: D004268:DNA-Binding Proteins; D051717:Fushi Tarazu Transcription Factors; D018398:Homeodomain Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D054339:Steroidogenic Factor 1; D014157:Transcription Factors; D019405:Cytochrome P-450 CYP11B2