[A case of extraovarian primary peritoneal carcinoma successfully treated with weekly paclitaxel].
We report the use of paclitaxel in the successful treatment of a 74-year-old patient with extraovarian primary peritoneal carcinoma and acute renal failure caused by intraperitoneal cisplatin. The histological diagnosis was papillary serous adenocarcinoma. Paclitaxel was given intravenously at 70 mg/m2 in a 1-hour infusion weekly for 6 consecutive weeks followed by 2-weeks rest (one cycle). Toxicities including neutropenia and neurotoxicity were mild. She showed a clinical response after three cycles, and then underwent secondary cytoreductive surgery after which she received one additional cycle of therapy. She enjoyed a favorable quality of life without evidence of disease for 16 months after the completion of this therapy. Weekly 1-hour paclitaxel (70 mg/m2) was well tolerated, yet was effective for extraovarian primary peritoneal carcinoma.
Nishio
Shin
S
Dept. of Obstetrics and Gynecology, Kumamoto Municipal Hospital.
Kawata
Takanobu
T
Harada
Chieko
C
Kawagoe
Hidehiro
H
Fujiyoshi
Keizou
K
Ishimatsu
Junji
J
Tsunawaki
Akitsu
A
Sugiyama
Toru
T
Kamura
Toshiharu
T
D058186:Acute Kidney Injury / Q000139:chemically induced; D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D002945:Cisplatin / Q000009:adverse effects; D018283:Cystadenocarcinoma, Papillary / Q000188:drug therapy* / Q000601:surgery; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D017239:Paclitaxel / Q000008:administration & dosage*; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000601:surgery
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel; D002945:Cisplatin