title: Determination of serum organic acids in puppies with naturally acquired parvoviral enteritis.
abstract: The purpose of the present study was to investigate the acid-base status and the serum concentration of organic acids in puppies with naturally occurring canine parvoviral enteritis. Between July 1999 and July 2000, 25 client-owned puppies admitted to the St. Louis Animal Emergency Clinic South for treatment of enteritis caused by parvovirus infection were used in our study. Control blood samples were collected from 22 healthy puppies less than 9 months of age. Serum organic acid concentrations were quantitatively determined by HPLC. Puppies infected with parvovirus had significantly lower plasma concentrations of sodium, potassium, chloride, and bicarbonate than controls. Although serum L-lactate tended to increase in some puppies with canine parvoviral enteritis, our study demonstrated that most affected puppies developed only mild compensated metabolic acidosis. None of the affected puppies had an elevated serum D-lactate concentration at admission.
authors.affiliation: Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri-Columbia, 65211, USA. nappertg@ultim.net
authors.forename: Germain
authors.initials: G
authors.lastname: Nappert
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Dunphy
authors.forename: Dawn
authors.initials: D
authors.lastname: Ruben
authors.forename: F A
authors.initials: FA
authors.lastname: Mann
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000097:blood; D000085:Acetates / Q000097:blood; D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D000831:Animals, Newborn; D001784:Blood Gas Analysis / Q000662:veterinary; D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000662:veterinary; D004283:Dog Diseases / Q000097:blood* / Q000209:etiology / Q000821:virology; D004285:Dogs; D004573:Electrolytes / Q000097:blood; D004751:Enteritis / Q000097:blood / Q000150:complications / Q000662:veterinary* / Q000821:virology; D005260:Female; D019344:Lactic Acid / Q000097:blood; D008297:Male; D010322:Parvoviridae Infections / Q000097:blood / Q000150:complications / Q000662:veterinary*; D017993:Parvovirus, Canine; D019289:Pyruvic Acid / Q000097:blood
chemical_list: D000085:Acetates; D004573:Electrolytes; D019344:Lactic Acid; D019289:Pyruvic Acid; D020155:3-Hydroxybutyric Acid