title: The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas.
abstract: The influence of combretastatin A-4 disodium phosphate (CA-4, 50mg/kg intraperitoneally (i.p.)) and vinblastine (2mg/kg i.p.) on interstitial fluid pressure (IFP) was assessed in BT4An rat gliomas implanted subcutaneously in the neck. Furthermore the growth inhibitory effect of vinblastine and the distribution of fluorescence-conjugated vinblastine (BODIPY-vinblastine) were investigated. Tumors at different volumes were compared. Whereas CA-4 had no major influence on IFP, independent of tumor size, vinblastine increased the IFP in neoplasms above 8 cm(3) (P=0.03). Vinblastine yielded a significant tumor response only in tumors below 2.1 cm(3) (P=0.03). The distribution of BODIPY-vinblastine was heterogeneous and comparable despite tumor volume differences. We conclude that the influence of vinblastine on IFP is more pronounced than that of CA-4 in BT4An neck tumors, and that vinblastine may reduce subsequent drug delivery to solid tumors by increasing the IFP.
authors.affiliation: Department of Oncology, University of Bergen, Haukeland University Hospital, 5021 Bergen, Norway. hans_eikesdal@hotmail.com
authors.forename: Hans Petter
authors.initials: HP
authors.lastname: Eikesdal
authors.forename: Willy
authors.initials: W
authors.lastname: Landuyt
authors.forename: Olav
authors.initials: O
authors.lastname: Dahl
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D005110:Extracellular Space / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005910:Glioma / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009368:Neoplasm Transplantation; D011312:Pressure; D051381:Rats; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use; D014747:Vinblastine / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; D014747:Vinblastine; C058728:fosbretabulin