[Tolerance to cardiotoxic effect of strophanthane K in experimental total heart block and electrocardiostimulation].
Tolerance to the cardiotoxic effect of strophanthin K was studied in narcotized dogs with experimental complete heart block (CHB) and ventricular electrostimulation. A threshold to the toxic arrhythmogenic effect of strophanthin K was significantly reduced as compared to that in the control group. As the electrocardiostimulation (ECS) frequency increased, the minimum arrhythmogenic dose of strophanthin K showed a growth, while not reaching a level for the sinus rhythm. It is concluded that the basic mechanisms of the arrhythmogenic effect of strophanthin K under the conditions studied are the trigger activity in dogs with ECS and the increased peacemaker's activity in dogs with CHB.
Iskenderov
B G
BG
Department of Therapy, Penza State Institute of Postgraduate Medical Training, ul. Stasova 8, Penza, 440060 Russia.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology; D001161:Arteriosclerosis / Q000503:physiopathology; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006327:Heart Block; D008297:Male; D013328:Strophanthins / Q000009:adverse effects / Q000494:pharmacology*
D013328:Strophanthins; C029082:strophanthin K