[Optimal conditions for extraction of "caffetin" and "saridon" tablet components from aqueous solutions].
Using a mathematical method of experiment planning (Latin square), the authors suggest the optimal conditions for extraction of propifenasone and paracetamol, the basic components of caffeine and saridon tablets, from water solutions: extraction with ethylacetate (pH 2) for 5 min in the presence of an electrolyte (sodium chloride or ammonium sulfate) quantum satis. The possibility of extraction of caffeine and codeine under these conditions was tested. When extracting the components of caffeine and saridon tablets, paracetamol, propifenasone, and caffeine should be extracted with ethylacetate at pH 2 and codeine by chloroform at pH 10.
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D000082:Acetaminophen / Q000302:isolation & purification*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification*; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000302:isolation & purification*; D002110:Caffeine / Q000302:isolation & purification*; D003061:Codeine / Q000302:isolation & purification*; D004338:Drug Combinations; D006863:Hydrogen-Ion Concentration; D010615:Phenacetin / Q000302:isolation & purification*; D011728:Pyridones / Q000302:isolation & purification*; D012996:Solutions; D013607:Tablets / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D011728:Pyridones; D012996:Solutions; D013607:Tablets; C106429:caffeine, codeine, acetaminophen, propyphenazone drug combination; D014867:Water; D000082:Acetaminophen; D002110:Caffeine; C019552:Saridon; D010615:Phenacetin; D000983:Antipyrine; D003061:Codeine