title: [Acute gastrointestinal bleeding in patients with antithrombotic therapy].
abstract: Approximately one-fifth of the patients, referred to the acute gastrointestinal bleeding unit took antithrombotic drugs (anticoagulants and antiplatelet agents) in a dose or with an effect, which made the causal relationship with acute bleeding episodes unequivocal. This paper analyzes the data of the first 100 such patients of the ward. The majority used acethyl-salicylic acid derivatives, however, a substantial number were on coumarol, and some bleeding patients with prosthetic heart valves were also observed. Haemostasis was forced by urgent, accurate, intervention based endoscopy along with simultaneous rapid efforts to correct the underlying clotting abnormalities. Prosthetic valve patients needed special care and attendance, and the reinstitution of anticoagulant treatment as soon as possible to maintain valve patency. The experiences and schedules of the authors, as well as the proposals of the literature are reviewed and summarized.
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Orvostudományi Kar, II. Belgyógyászati Klinika.
authors.forename: Miklós
authors.initials: M
authors.lastname: Udvardy
authors.forename: Károly
authors.initials: K
authors.lastname: Palatka
authors.forename: István
authors.initials: I
authors.lastname: Tornai
authors.forename: István
authors.initials: I
authors.lastname: Altorjay
mesh_terms: D000208:Acute Disease; D000925:Anticoagulants / Q000009:adverse effects; D001241:Aspirin / Q000009:adverse effects; D003374:Coumarins / Q000009:adverse effects; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000188:drug therapy; D006350:Heart Valve Prosthesis; D006490:Hemostatics / Q000627:therapeutic use; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects
chemical_list: D000925:Anticoagulants; D003374:Coumarins; D006490:Hemostatics; D006493:Heparin; C030123:coumarin; D003894:Deamino Arginine Vasopressin; D013988:Ticlopidine; D001241:Aspirin