The "Down's" side of mitochondria.
The mechanisms involved in the development of Alzheimer disease-type pathology in patients with Down's syndrome are unclear. However, a paper published in the February 28 issue of Neuron indicates that mitochondrial dysfunction is pivotally involved.
Ogawa
Osamu
O
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Perry
George
G
Smith
Mark A
MA
D000544:Alzheimer Disease / Q000378:metabolism*; D004314:Down Syndrome / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology