Stereocontrolled total synthesis of (+)-vinblastine.
A stereocontrolled total synthesis of (+)-vinblastine was accomplished, featuring preparations of the two indole units by means of a novel indole synthesis via radical cyclization of thioanilide, and a stereoselective coupling of these units.
Yokoshima
Satoshi
S
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Ueda
Toshihiro
T
Kobayashi
Satoshi
S
Sato
Ayato
A
Kuboyama
Takeshi
T
Tokuyama
Hidetoshi
H
Fukuyama
Tohru
T
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D030008:Catharanthus / Q000737:chemistry; D013237:Stereoisomerism; D014747:Vinblastine / Q000138:chemical synthesis*
D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine