[Status cataplecticus induced by abrupt withdrawal of clomipramine].
BACKGROUND
Cataplexy is one of the main narcoleptic symptoms and is characterized by sudden loss of muscle tone triggered by emotional stimuli while consciousness is mantained. Clomipramine is an effective treatment of cataplexy. Cataplexy that occurs repeatedly for hours or days is referred to as status cataplecticus.


METHODS
We report three adults with narcolepsy in whom cataplexy was chronically and effectively treated with clomipramine (75-150 mg/day). For diverse reasons, these three patients had an abrupt withdrawal of clomipramine, and after 2-9 days patients showed an invalidant status cataplecticus characterized by a marked increase of the frequency, duration and severity of their cataplectic attacks that were now elicited by mild emotional stimuli. After introduction of anticataplectic agents (clomipramine in two patients and fluoxetine in one patient), status cataplecticus was resolved in less than a week.


CONCLUSIONS
In patients with narcolepsy, abrupt withdrawal of chronic treatment with clomipramine may be associated with status cataplecticus. This condition may be resolved with the reintroduction of anticataplectic agents.
Martínez-Rodríguez
J E
JE
Servicio de Neurología. Hospital Clínic i Provincial de Barcelona. Spain.
Iranzo
A
A
Santamaría
J
J
Genís
D
D
Molins
A
A
Silva
Y
Y
Meléndez
R
R