[Clinicopathological study of mucosa-associated lymphoid tissue lymphoma of salivary glands].
OBJECTIVE
To study the histopathological features and pathogenesis of mucosa associated lymphoid tissue lymphoma (MALT-oma) of salivary glands.


METHODS
Surgical specimens from 27 cases of MALT-oma of salivary glands were studied using paraffin-embedded section, immunohistochemical method (SP method) and electron microscope.


RESULTS
12 tumors were located in the pariotid glands, the other 15 in the submandibular glands. Much of the MALT-oma of the salivary glands were composed of diffuse centrocyte-like (CCL) cells with "lymphoepithelial lesions". Immunohistochemically, CD20 expression was found to be positive and CD45RO expression was negative in all MALT-omas of salivary glands.


CONCLUSIONS
Most of the MALT-omas are low grade malignant tumors and the tumor cells have a "homing back" phenomenon. A small number of MALT-omas can become highly malignant tumors with poor prognosis. Acquired MALT may develop as a reaction to autoimmune disease and/or infection. Hyperimmune reaction and MALT hyperplasia under continuous stimulation may result in myoepithelial sialadenitis and develop into MALT-oma of salivary glands.
Shi
Q
Q
Department of Pathology, Nanjing General Hospital of the PLA, Nanjing 210002.
Zhang
T
T
Yan
X
X
Shou
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017493:Leukocyte Common Antigens / Q000032:analysis; D018442:Lymphoma, B-Cell, Marginal Zone / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000473:pathology*
D018951:Antigens, CD20; D017493:Leukocyte Common Antigens