Activated protein C in severe sepsis.
A recent large trial has shown that recombinant activated protein C reduced mortality in severe sepsis. This is the first real advance in the pharmacotherapy of sepsis since the introduction of antibiotics in the last century.
Bradley
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C
St George's Hospital, London, UK.
D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D002986:Clinical Trials as Topic; D006801:Humans; D011486:Protein C / Q000378:metabolism* / Q000627:therapeutic use*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011994:Recombinant Proteins / Q000627:therapeutic use*; D012720:Severity of Illness Index; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy* / Q000378:metabolism*; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D001779:Blood Coagulation Factors; D011486:Protein C; D011956:Receptors, Cell Surface; D011994:Recombinant Proteins; C091963:activated protein C receptor; C421124:drotrecogin alfa activated