title: Evaluation of E-721B, an indigenous herbal combination in experimental models of immediate hypersensitivity.
abstract: E-721B, an indigenous herbal combination was investigated for its usefulness in immediate hypersensitivity using different animal models. The drug inhibited the mast cell degranulation induced both by antigen and compound 48/80, the Schultz-Dale response in sensitized guinea pig ileum smooth muscle preparation and the production of precipitating antibodies in 50% of tested rats. It also inhibited the mast cell degranulation in passively sensitized rats indicating its suppressive action on production of reaginic antibody (IgE). However, the drug did not inhibit the 48 hours passive cutaneous anaphylaxis reaction in rats, indicating that a single dose of the drug does not have cromoglycate like properties. All the above results indicate the inhibitory effect of E-721B on immediate hypersensitive reactions such as asthma.
authors.affiliation: Department of Pharmacology, Government College of Pharmacy, P. Kalinga Rao Road, Bangalore-560 027.
authors.forename: M
authors.initials: M
authors.lastname: Lakshmana
authors.forename: M
authors.initials: M
authors.lastname: Rafiq
authors.forename: B Y
authors.initials: BY
authors.lastname: Sridhar
mesh_terms: D000707:Anaphylaxis / Q000188:drug therapy; D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D015550:Cell Degranulation / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006736:Horses / Q000276:immunology; D006969:Hypersensitivity, Immediate / Q000188:drug therapy*; D007082:Ileum / Q000187:drug effects; D005779:Immunodiffusion; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D008515:Medicine, Ayurvedic; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D018926:Anti-Allergic Agents; C462959:E-721B; D010936:Plant Extracts; D003189:p-Methoxy-N-methylphenethylamine