Synthesis of a new class of chiral 1,5-diphosphanylferrocene ligands and their use in enantioselective hydrogenation.
A new family of ferrocenylphosphane ligands has been prepared. Their flexible synthesis allows many structural modifications. The asymmetric induction of these ligands was examined in the hydrogenation of functionalized C=C, C=O, and C=N bonds. The enantioselectivity of the reaction was strongly dependent on the substituent R at the position alpha to the ferrocene moiety. In many cases, both enantiomeric beta-hydroxyesters of the reduction product can be obtained by simply replacing a dimethylamino group in the ligand with a methyl group.
Ireland
Tania
T
RHODIA Recherches, Centre de Recherche de Lyon Groupe Catalyse 85 avenue des Frères Perret, 69192 Saint Fons, France.
Tappe
Katja
K
Grossheimann
Gabi
G
Knochel
Paul
P