title: [Effect of Rhaponticum carthamoides extract on hemorheological properties of blood in rats with arterial hypertension].
abstract: The hemorheological activity of a dry extract from Rhaponticum (Leuzea) carthamoides (Willd.) Iljin. was studied in spontaneously hypertensive rats (SHRs). A 14-day treatment of the test rats with a daily dose of 150 mg/kg improved the rheological characteristics, as manifested by a reduced viscosity of the whole blood and plasma, increased spontaneous erythrocyte aggregation and fibrinogen concentration, and increased erythrocyte deformability and electrophoretic mobility against the untreated control level.
authors.affiliation: Laboratory of Circulatory, Tomsk Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
authors.forename: O I
authors.initials: OI
authors.lastname: Aliev
authors.forename: A S
authors.initials: AS
authors.lastname: Vasil'ev
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Maslov
authors.forename: S E
authors.initials: SE
authors.lastname: Dmitruk
authors.forename: E A
authors.initials: EA
authors.lastname: Krasnov
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002449:Cell Aggregation / Q000187:drug effects; D004586:Electrophoresis; D004907:Erythrocyte Deformability / Q000187:drug effects; D005340:Fibrinogen / Q000378:metabolism; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D012212:Rheology / Q000187:drug effects*
chemical_list: D000959:Antihypertensive Agents; D010936:Plant Extracts; D005340:Fibrinogen