title: Extragonadal retroperitoneal germ cell tumor: evidence of origin in the testis.
abstract: BACKGROUND
  The origin of extragonadal retroperitoneal germ cell tumors remains controversial. Whether they develop primarily in the retroperitoneum or whether they are metastases of a primary testicular tumor has long been debated.
  
  
  METHODS
  We retrospectively analyzed 26 patients treated as having primary extragonadal retroperitoneal germ cell tumors based upon the findings of testicular palpation by the referring physician. Testicular evaluation was then extended with ultrasonographical and histological examinations.
  
  
  RESULTS
  Biopsy of the extragonadal tumor was performed in 25 patients, confirming diagnosis of extragonadal retroperitoneal germ cell tumor. Prior to treatment patients were clinically evaluated by several physicians and the testes were not considered suspicious for testicular cancer. At urological workup, testes were found to be atrophic and/or indurated in 14 (54%) patients, enlarged in one (4%) and unremarkable in 11 (42%). Ultrasound examination of the testes in 20 patients showed pathological findings in all of them. Histology of the testis was available in 25 of 26 patients and revealed active tumor in three, intratubular germ cell neoplasia in four, scar tissue in 12, sclerosis in three, sclerosis and fibrosis in one, and fibrosis alone in two.
  
  
  CONCLUSIONS
  So-called primary extragonadal germ cell tumors in the retroperitoneum are very likely a rare or non-existing entity and should be considered as metastases of a viable or burned-out testicular cancer until proven otherwise. All of our patients with histologically examined testes had pathological finding, 76% of which were either viable tumor or scars.
authors.affiliation: Department of Urology, Institute of Medical Oncology, University of Berne, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Scholz
authors.forename: M
authors.initials: M
authors.lastname: Zehender
authors.forename: G N
authors.initials: GN
authors.lastname: Thalmann
authors.forename: M
authors.initials: M
authors.lastname: Borner
authors.forename: H
authors.initials: H
authors.lastname: Thöni
authors.forename: U E
authors.initials: UE
authors.lastname: Studer
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D018450:Disease Progression; D018237:Germinoma / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D012189:Retrospective Studies; D015996:Survival Rate; D013737:Testis / Q000473:pathology*; D013997:Time Factors