title: Intrinsic positive end-expiratory pressure during one-lung ventilation of patients with pulmonary hyperinflation. Influence of low respiratory rate with unchanged minute volume.
abstract: BACKGROUND
  We measured lung mechanics and gas exchange during one-lung ventilation (OLV) of patients with chronic obstructive pulmonary disease, using three respiratory rates (RR) and unchanged minute volume.
  
  
  METHODS
  We studied 15 patients about to undergo lung surgery, during anaesthesia, and placed in the lateral position. Ventilation was with constant minute volume, inspiratory flow and FIO2. For periods of 15 min, RR of 5, 10, and 15 bpm were applied in a random sequence and recordings were made of lung mechanics and an arterial blood gas sample was taken. Data were analysed with the repeated measures ANOVA and paired t-test with Bonferroni correction.
  
  
  RESULTS
  PaO2 changes were not significant. At the lowest RR, PaCO2 decreased (from 42 (SD 4) mm Hg at RR 15-41 (4) mm Hg at RR 10 and 39 (4) mm Hg at RR 5, P<0.01), and end-tidal carbon dioxide increased (from 33 (5) mm Hg at RR 15 to 35 (5) mm Hg at RR 10 and 36 (6) mm Hg at RR 5, P<0.01). Intrinsic positive end-expiratory pressure (PEEPi) was reduced even with larger tidal volumes (from 6 (4) cm H2O at RR 15-5 (4) cm H2O at RR 10, and 3 (3) cm H2O at RR 5, P<0.01), most probably caused by increased expiratory time at the lowest RR.
  
  
  CONCLUSIONS
  A reduction in RR reduces PEEPi and hypercapnia during OLV in anaesthetized patients with chronic obstructive lung disease.
authors.affiliation: Department of Anaesthesiology, Ghent University Hospital, Belgium.
authors.forename: L L
authors.initials: LL
authors.lastname: Szegedi
authors.forename: L
authors.initials: L
authors.lastname: Barvais
authors.forename: Y
authors.initials: Y
authors.lastname: Sokolow
authors.forename: J C
authors.initials: JC
authors.lastname: Yernault
authors.forename: A A
authors.initials: AA
authors.lastname: d'Hollander
mesh_terms: D000368:Aged; D002245:Carbon Dioxide / Q000097:blood; D006801:Humans; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D018467:Positive-Pressure Respiration, Intrinsic / Q000503:physiopathology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012121:Respiration, Artificial / Q000379:methods*; D015656:Respiratory Mechanics; D013908:Thoracotomy
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen