Antiallergic effect of flavonoid glycosides obtained from Mentha piperita L.
Six flavonoid glycosides, eriocitrin (1), narirutin (2), hesperidin (3), luteolin-7-O-rutinoside (4), isorhoifolin (5), diosmin (6), rosmarinic acid (7) and 5,7-dihydroxycromone-7-O-rutinoside (8), were isolated from the aerial part of Mentha piperita L. Among these compounds, compound 4 showed a potent inhibitory effect on histamine release induced by compound 48/80 and antigen-antibody reaction. This compound was more effective than luteolin and luteolin-7-O-glucoside in inhibiting histamine release from rat peritoneal mast cells. Compound 4 also caused a dose-related inhibition of the antigen-induced nasal response and significant effects were observed at doses of 100 and 300 mg/kg. These results indicate that compound 4 may be clinically useful in alleviating the nasal symptoms of allergic rhinitis.
Inoue
Toshio
T
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Sugimoto
Yukio
Y
Masuda
Hideki
H
Kamei
Chiaki
C
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D027541:Mentha / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012912:Sneezing / Q000187:drug effects
D018926:Anti-Allergic Agents; D005419:Flavonoids; D006027:Glycosides