In vivo evidence for brain-to-blood efflux transport of valproic acid across the blood-brain barrier.
Kakee
Atsuyuki
A
Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Takanaga
Hitomi
H
Hosoya
Ken-ichi
K
Sugiyama
Yuichi
Y
Terasaki
Tetsuya
T
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D018682:GABA Agents / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D015233:Models, Statistical; D021381:Protein Transport; D051381:Rats; D017207:Rats, Sprague-Dawley; D014635:Valproic Acid / Q000494:pharmacology*
D018682:GABA Agents; D014635:Valproic Acid