[Relationship between soluble Fas ligand levels and complications after allogeneic bone marrow transplantation].
OBJECTIVE
To evaluate the implications of soluble Fas ligand (sFasL) in acute graft-versus-host disease (aGVHD) and discriminating symptoms of aGVHD from those of infection.


METHODS
Plasma levels of sFasL were assessed in 84 plasma samples from 13 patients after allogeneic BMT using a sandwich enzyme-linked immunological assay (ELISA). Plasma sFasL levels of the patients before BMT and at different time points in the post-BMT period were measured. The results were analysed for correlation with aGVHD and infections.


RESULTS
Plasma sFasL levels were significantly higher in patients with grade II - IV aGVHD than that in those with grade 0 - I aGVHD (P = 0.02). There was no statistic difference in plasma sFasL levels between the infectious and non-infectious patients. In the seven grade II - IV aGVHD patients, the plasma sFasL levels pre-BMT were much lower than that in the six grade 0 - I aGVHD patients.


CONCLUSIONS
sFasL may be useful for the diagnosis of aGVHD and for differentiating aGVHD from other BMT related complications. The high level of plasma sFasL pre-BMT may be of importance in decreasing the occurrence of aGVHD after BMT.
Huang
X
X
Institute of Hematology, People's Hospital, Peking University, Beijing 100044, China.
Wan
J
J
Guo
N
N
Lu
D
D
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D053222:Fas Ligand Protein / Q000097:blood*; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D014184:Transplantation, Homologous / Q000009:adverse effects; D055815:Young Adult
D053222:Fas Ligand Protein