Effect of bismuth subgallate (local hemostatic agent) on wound healing in rats. Histological and histometric findings.
The aim of this research was to evaluate the effect of bismuth subgallate on wound healing. In 40 Wistar rats, two standard wounds (3.5 mm x 2 mm) were made using a biopsy punch on the back of each animal. Test wounds were filled with bismuth subgallate and control wounds with 0.9% saline. At 1, 4, 7, 11 and 18 days, the qualitative evolution of the granulation tissue morphology was observed and digitalized histologic images were evaluated. There were no significant histological differences between test and control. Histometrically, there were statistically significant differences between test and control (ANOVA--days 1 and 4; Student t test, p < 0.05--days 7, 11 and 18) in terms of the following parameters: area of ulceration--day 1; distance between epithelial edges--day 4; area of granulation tissue--days 7, 11 and 18. It was concluded that bismuth subgallate is biocompatible to the healing tissue, and did not interfere with the normal development of wound healing.
Tramontina
Vinicius Augusto
VA
Department of Periodontics, Faculty of Dentistry of Piracicaba, UNICAMP, Piracicaba, SP, Brazil. vtramontina@bol.com.br
Machado
Maria Angela Naval
MA
Nogueira Filho
Getúlio da Rocha
Gda R
Kim
Sung Hyun
SH
Vizzioli
Mário R
MR
Toledo
Sérgio de
Sd
D000704:Analysis of Variance; D000818:Animals; D001729:Bismuth / Q000494:pharmacology*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006097:Granulation Tissue / Q000187:drug effects; D006490:Hemostatics / Q000494:pharmacology*; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
D006490:Hemostatics; D009942:Organometallic Compounds; D005707:Gallic Acid; D001729:Bismuth; C002170:bismuth subgallate