title: Nephrotoxicity due to intermediate-dose methotrexate without rescue in an obese adolescent with acute lymphoblastic leukemia.
abstract: Toxicity from intermediate-dose methotrexate (MTX) is unusual. A severely obese adolescent with acute lymphoblastic leukemia experienced significant, delayed nephrotoxicity from intermediate-dose MTX. Altered MTX disposition may occur as a consequence of other ingestions or conditions such as obesity. The use of radioisotope renography established the diagnosis and followed the resolution of the patient's MTX-induced nephrotoxicity.
authors.affiliation: Department of Pediatrics, Bone Marrow Transplantation, University of Minnesota, Minneapolis, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Sauer
authors.forename: Nancy
authors.initials: N
authors.lastname: Rydholm
authors.forename: John
authors.initials: J
authors.lastname: Piatkowski
authors.forename: Victor
authors.initials: V
authors.lastname: Lewis
authors.forename: Marie
authors.initials: M
authors.lastname: Steiner
mesh_terms: D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D009765:Obesity / Q000150:complications*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D011866:Radioisotope Renography
chemical_list: D000964:Antimetabolites, Antineoplastic; D002955:Leucovorin; D008727:Methotrexate