title: Modulating effects of epithalamin and epithalon on the functional morphology of the spleen in old pinealectomized rats.
abstract: Immunohistochemical and morphometric analysis showed that epithalamin and epithalon produced similar effects on the functional morphology of the spleen in pinealectomized rats. Both peptides prevented hyperplasia of lymphoid cells in follicular germinative centers induced by pinealectomy and potentiated the decrease in extramedullary hemopoiesis. These findings confirm the data on functional relationships between the pineal gland and immune system. The effects of epithalamin and epithalon on cell and tissue homeostasis in the spleen of old pinealectomized rats can be regarded as a manifestation of the general regulatory effect of these peptides.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences.
authors.forename: V K
authors.initials: VK
authors.lastname: Khavinson
authors.forename: S S
authors.initials: SS
authors.lastname: Konovalov
authors.forename: V V
authors.initials: VV
authors.lastname: Yuzhakov
authors.forename: V V
authors.initials: VV
authors.lastname: Popuchiev
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D007150:Immunohistochemistry; D008297:Male; D009336:Necrosis; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D010870:Pineal Gland / Q000378:metabolism*; D018809:Proliferating Cell Nuclear Antigen / Q000494:pharmacology; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D009842:Oligopeptides; D010455:Peptides; D018809:Proliferating Cell Nuclear Antigen; D011453:Prostaglandins; C027437:epithalamin; C421253:alanyl-glutamyl-aspartyl-glycine