Metalation of 2-chloromethyl-2-oxazolines: synthesis of 1,2,3-tris(oxazolinyl)cyclopropanes and derivatives.
2-Chloromethyl-2-oxazoline converts cleanly into trans-1,2,3-tris(oxazolinyl)cyclopropane upon treatment with strong bases such as LDA or KN(SiMe(3))(2). Deprotonation of the above cyclopropane followed by the addition of electrophiles allows the preparation of more functionalized tris(oxazolinyl)cyclopropanes.
Capriati
Vito
V
Centro C.N.R. M.I.S.O., Dipartimento Farmaco-Chimico, Università di Bari, Via E. Orabona 4, I-70125 Bari, Italy.
Florio
Saverio
S
Luisi
Renzo
R
Rocchetti
Maria Teresa
MT