[Progressive multifocal leukoencephalopathy revealing AIDS in a 13-year-old girl].
METHODS
A 13-year-old girl with an immunosuppression developed a right hemiparesis and a cerebellar syndrome. She was seropositive for HIV. A progressive multifocal leukoencephalopathy (PML) was suspected because of white matter lesions (MRI) and established on detection of JC virus in CSF by polymerase chain reaction (PCR). In spite of highly active antiretroviral treatment (HAART) and cidofovir, she died three months later.


CONCLUSIONS
Late AIDS diagnosis was established during a neurological complication, 13 years after a neonatal transmission. PML caused by JC opportunistic virus still has a poor prognosis.
Hugonenq
C
C
Service de neurologie pédiatrique, hôpital d'enfants de la Timone, boulevard Jean-Moulin, 13385 Marseille, France.
Lethel
V
V
Chambost
H
H
Michel
G
G
Chabrol
B
B
Mancini
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality / Q000635:transmission; D000293:Adolescent; D000367:Age Factors; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D002555:Cerebrospinal Fluid / Q000821:virology; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006679:HIV Seropositivity; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D007577:JC Virus / Q000302:isolation & purification; D007968:Leukoencephalopathy, Progressive Multifocal / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D008279:Magnetic Resonance Imaging; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000627:therapeutic use; D016133:Polymerase Chain Reaction; D011379:Prognosis; D013997:Time Factors
D019380:Anti-HIV Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir