[Relation between Beta-2-glycoprotein I and hepatitis B virus surface antigen].
OBJECTIVE
To clarify the binding character between Beta-2-glycoprotein I (Beta-2-GPI) and HBsAg.


METHODS
Beta-2-GPI was purified from human plasma and labelled with biotin. Solid phase enzyme linked absorbance assay was used to investigate its binding with HBsAg.


RESULTS
Biotinylated Beta-2-GPI was found to bind HBsAg and the reaction could be inhibited by excess unlabelled Beta-2-GPI.


CONCLUSIONS
Beta-2-GPI may play a role in hepatitis B virus infection.
Gao
Pujun
P
Department of Internal Medicine, the First Affiliated Hospital, Norman Bethune University of Medical Sciences, Changchun 130021, China.
Guo
Yanjun
Y
Qu
Like
L
Shi
Tong
T
Zhang
Hongyan
H
Dong
Chun'e
C
Yang
Hanyi
H
D001665:Binding Sites; D019921:Biotinylation; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006023:Glycoproteins / Q000302:isolation & purification / Q000378:metabolism*; D006514:Hepatitis B Surface Antigens / Q000378:metabolism*; D006515:Hepatitis B virus / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D053482:beta 2-Glycoprotein I
D006023:Glycoproteins; D006514:Hepatitis B Surface Antigens; D053482:beta 2-Glycoprotein I