Cytotoxic coumaronochromones from the roots of Euchresta formosana.
Five new coumaronochromones, euchretins J-N (1 - 5), along with twelve known compounds, euchretins A (6), C, D, F, H, I, (+)-matrine, (-)-cytisine, quercetin, trifolirhizin, retusin 8-methyl ether, and genistein, were isolated from the methanolic extracts of Euchresta formosana. The structures of compounds 1 - 5 were established by spectroscopic analyses. Among them, compounds 1, 4 and 6 were demonstrated to have cytotoxicity against 59T cell line, and compound 1 was also found to be active against SCM-1 cell line.
Lo
Wen-Li
WL
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chang
Fang-Rong
FR
Liaw
Chih-Chuang
CC
Wu
Yang-Chang
YC
D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007887:Fabaceae; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D002867:Chromones; D003374:Coumarins; D005419:Flavonoids; D010936:Plant Extracts