title: [Echinococcoses].
abstract: Human echinococcoses, cystic echinococcosis and alveolar echinococcosis are due to infections with the cestodes Echinococcus granulosus and E. multilocularis, respectively. Both zoonoses share a prolonged latency period before clinical presentation. However their evolution is fairly different: that of a begin tumor of the liver or lung for cystic echinoccocosis, and that of a slowly developing malignant tumor of the liver for alveolar echinoccocosis, with subsequent invasion of liver vessels and bile ducts and metastatic dissemination. Ultrasonography, CT-scan and specific serology are the key-exams for diagnosis. In both forms, surgery is the treatment of choice when a complete resection is possible. Liver transplantation may be an ultimate treatment option in very advanced cases of alveolar echinoccocosis. However, alternative treatment procedures have been proposed in the past 15 years and, combined with an earlier diagnosis, they have markedly improved patients survival and quality of life. Interventional radiology (puncture, aspiration, injection, reaspiration) has become a fully validated treatment of cystic echinoccocosis, and may be used in alveolar echinoccocosis for alleviating some of the complications of the disease such as biliary obstruction or bacterial superinfection. Albendazole, at high dosage, is a necessary complementary treatment after any intervention procedure, and for life when radical resection is not possible. Prevention relies on personal measures of hygiene and heating of contaminated food, and on collective measures aimed at reducing cestode egg shedding by the feces of infected canivores.
authors.affiliation: Service d'hépatologie et de soins intensifs digestifs, CHU Jean-Minjoz, Groupe de recherche Santé-Environnement rural Université de Franche-Comté.
authors.forename: S
authors.initials: S
authors.lastname: Bresson-Hadni
authors.forename: D A
authors.initials: DA
authors.lastname: Vuitton
mesh_terms: D015746:Abdominal Pain / Q000469:parasitology; D015766:Albendazole / Q000627:therapeutic use; D000923:Anticestodal Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D004443:Echinococcosis / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D005516:Food Microbiology; D006498:Hepatectomy; D006529:Hepatomegaly / Q000469:parasitology; D006801:Humans; D006920:Hygiene; D007565:Jaundice / Q000469:parasitology; D016031:Liver Transplantation; D011013:Pneumonectomy; D011379:Prognosis; D015642:Radiology, Interventional; D014057:Tomography, X-Ray Computed; D015047:Zoonoses
chemical_list: D000923:Anticestodal Agents; D015766:Albendazole