[Ultrastructural changes of epitheliocytes and vessels of the small intestinal microcirculatory system in rabbit pups infected with cholera vibrions].
10-12 days old suckling rabbits-pups were infected by cholera vibrions of 01329 serogroup (16063 and M045 strains). Ultrastructural changes in small intestinal epitheliocytes and microcirculatory vessels were studied. Both strains caused typical cholerogenic syndrome, dystrophic and necrotic changes in epitheliocytes, epitheliocytes and lymphocytes, increase of vessel permeability, rheological disorders. Focal cytoplasmic were formed, widening of intercellular spaces were observed, although the zone of dense contact was not disturbed. M045 strains caused destruction of dense contacts, resulting in loose arrangement of epitheliocytes and their division from the basement membrane.
Shamirzaev
N Kh
NKh
Laboratory of Pathomorphology and Pathophysiology, Scientific Research Anti-Plaque Institute, Rostov-on-Don.
Nazarova
D E
DE
D000818:Animals; D000833:Animals, Suckling; D004730:Endothelium, Vascular / Q000166:cytology* / Q000382:microbiology / Q000648:ultrastructure; D004847:Epithelial Cells / Q000382:microbiology / Q000648:ultrastructure*; D007421:Intestine, Small / Q000166:cytology* / Q000382:microbiology / Q000648:ultrastructure; D008833:Microcirculation; D011817:Rabbits; D014734:Vibrio cholerae / Q000502:physiology*