[An experimental study on effects of biomembrane on prevention of filtering bleb adhesion in trabeculectomy].
OBJECTIVE
The study was designed to investigate the effects of biomembrane on experimental trabeculectomy.


METHODS
A biomembrane was implanted under the scleral flap and the conjunctival flap in trabeculectomy in one eye of rabbits, while the fellow eye of the same rabbit without biomembrane implantation was the control.


RESULTS
(1) The wound healing of the procedure reached its peak at 2-3 weeks after surgery, while the absorption of the biomembrane began at 6 weeks after surgery, and there was no tight adhesion between the biomembrane and the scar tissue, thus the filtering fistula was prevented from obstruction. (2) From the 2nd to the 7th week after surgery, the percentage of existing functional bleb in the experimental group was significantly higher than that in the control group (P < 0.05). (3) From the 1st to the 5th postoperative week, the decreasing of intraocular pressure in the experimental group was significantly greater than that in the control group (P < 0.05).


CONCLUSIONS
The use of biomembrane in trabeculectomy can prevent the adhesion of filtering bleb and decrease intraocular pressure more effectively, and this study can provide experimental reference for the clinical use of biomembrane.
Pu
W
W
Department of Ophthalmology, Second Affiliated Hospital of China Medical University, Shenyang 110003.
Gao
D
D
Wang
J
J
Li
W
W
Kang
H
H
D000818:Animals; D005260:Female; D005901:Glaucoma / Q000473:pathology / Q000601:surgery*; D007429:Intraocular Pressure; D008297:Male; D008567:Membranes, Artificial; D008854:Microscopy, Electron; D011817:Rabbits; D000267:Tissue Adhesions / Q000517:prevention & control*; D014130:Trabeculectomy / Q000009:adverse effects*; D014945:Wound Healing
D008567:Membranes, Artificial