title: Absolute stereochemistry of amphidinolide E.
abstract: The absolute configurations at eight chiral centers in amphidinolide E (1), a cytotoxic 19-membered macrolide isolated from a marine dinoflagellate Amphidinium sp., were determined to be 2R, 7R, 8R, 13S, 16S, 17R, 18R, and 19R on the basis of detailed analysis of NMR data and by chemical means.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kubota
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsuda
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002384:Catalysis; D004141:Dinoflagellida / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D000097442:Amphidinolides
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004952:Esters; D018942:Macrolides; C452448:amphidinolide E; D000097442:Amphidinolides