title: Remifentanil-sevoflurane anaesthesia for laparoscopic cholecystectomy: comparison of three dose regimens.
abstract: The objective of this study was to determine a dosing regimen for remifentanil-sevoflurane anaesthesia that achieves an optimal balance between quality of anaesthesia and time to recovery. Patients undergoing elective laparoscopic cholecystectomy were randomly allocated to receive 0.4, 0.8 or 1.2 MAC (minimal alveolar concentration) of sevoflurane combined with remifentanil as required to maintain stable anaesthesia. For induction of anaesthesia, the remifentanil dose was 25 microg x kg(-1) x h(-1) and the mean propofol dose which was required to obtain loss of consciousness was 1.59 mg x kg(-1). During the maintenance phase, the mean remifentanil dose was 16.0, 14.1 and 13.0 microg x kg(-1) x h(-1) for the 0.4, 0.8 and 1.2 MAC groups, respectively. The mean sevoflurane maintenance dose was 0.91, 1.24 and 2.1% end-tidal for the 0.4, 0.8 and 1.2 MAC groups, respectively. The incidence of somatic responses was significantly higher in the 0.4 MAC sevoflurane group. Recovery times were significantly faster in the 0.4 compared to the 0.8 and 1.2 MAC groups and in the 0.8 compared to the 1.2 MAC group. The combination of 14 microg x kg(-1) x h(-1) remifentanil and 1.24% end-tidal sevoflurane achieved the optimal balance between the quality, and recovery from anaesthesia.
authors.affiliation: Gelre ziekenhuisen Apeldoorn, The Netherlands.
authors.forename: P G
authors.initials: PG
authors.lastname: van Delden
authors.forename: P L
authors.initials: PL
authors.lastname: Houweling
authors.forename: A F
authors.initials: AF
authors.lastname: Bencini
authors.forename: E P
authors.initials: EP
authors.lastname: Ephraim
authors.forename: R C
authors.initials: RC
authors.lastname: Frietman
authors.forename: J
authors.initials: J
authors.lastname: van Niekerk
authors.forename: M A
authors.initials: MA
authors.lastname: van Stolk
authors.forename: R
authors.initials: R
authors.lastname: Verheijen
authors.forename: O J M
authors.initials: OJ
authors.lastname: Wajer
authors.forename: P G H
authors.initials: PG
authors.lastname: Mulder
mesh_terms: D000328:Adult; D000762:Anesthesia Recovery Period; D019162:Anesthetics, Combined / Q000008:administration & dosage*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D017081:Cholecystectomy, Laparoscopic; D004305:Dose-Response Relationship, Drug; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage*; D011183:Postoperative Complications; D000077208:Remifentanil; D000077149:Sevoflurane
chemical_list: D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D010880:Piperidines; D000077149:Sevoflurane; D000077208:Remifentanil