Tuberculosis transmitted through transplantation.
Tuberculosis in solid organ transplant recipients is associated with relatively high morbidity and mortality and is often extra-pulmonary. Reactivation of dormant infection is the usual mode of acquisition with donor and nosocomial transmission occurring infrequently. We report two cases of probable donor transmitted extra-pulmonary infection where both isolates of Mycobacterium tuberculosis proved to be indistinguishable using hemi-nested inverse PCR of the IS 6110 region.
Graham
J C
JC
Microbiology Department, Freeman Hospital, High Heaton, UK. j.c.graham@ncl.ac.uk
Kearns
A M
AM
Magee
J G
JG
El-Sheikh
M F
MF
Hudson
M
M
Manas
D
D
Gould
F K
FK
Orr
K E
KE
Freeman
R
R
D000328:Adult; D002102:Cadaver; D003428:Cross Infection / Q000175:diagnosis / Q000635:transmission; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D014376:Tuberculosis / Q000175:diagnosis* / Q000635:transmission*; D014386:Tuberculosis, Hepatic / Q000175:diagnosis / Q000635:transmission; D014398:Tuberculosis, Renal / Q000175:diagnosis / Q000635:transmission