title: [A case of advanced ovarian carcinosarcoma that responded remarkably to neoadjuvant chemotherapy of combined CPT-11 and CDDP].
abstract: Carcinosarcoma of the ovary is a very rare and highly malignant neoplasm that accounts for less than 1% of ovarian neoplasms. Survival of patients with advanced stage cancer is poor and the best treatment is not clear. We report the case of a 60-year-old woman who had Stage IV advanced heterogeneous ovarian carcinosarcoma with lung and liver metastases. The lesions were considered surgically incurable, so she was placed on neoadjuvant chemotherapy of combination CPT-11 (60 mg/m2, day 1, 15) and CDDP (60 mg/m2, day 1). Tumor markers of CA125 and LDH decreased remarkably to the normal level after 3 and 4 courses of chemotherapy, respectively. After 7 courses of chemotherapy, the ovarian tumor was obviously reduced, and the lung and liver metastases had disappeared. The patient was then able to undergo surgery. The current case suggests that combination CPT-11 and CDDP is effective against advanced ovarian carcinosarcoma.
authors.affiliation: Dept. of Obstetrics and Gynecology, Kasukabe Municipal General Hospital.
authors.forename: Masashi
authors.initials: M
authors.lastname: Takami
authors.forename: Tomoko
authors.initials: T
authors.lastname: Idei
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Hiroho
authors.initials: H
authors.lastname: Ohta
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Yoshichika
authors.initials: Y
authors.lastname: Togo
authors.forename: Hideki
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Satoh
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002296:Carcinosarcoma / Q000188:drug therapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D020883:Hysterotomy; D000077146:Irinotecan; D008197:Lymph Node Excision; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin