title: A multilateral effort to develop DNA vaccines against falciparum malaria.
abstract: Scientists from several organizations worldwide are working together to develop a multistage, multigene DNA-based vaccine against Plasmodium falciparum malaria. This collaborative vaccine development effort is named Multi-Stage DNA-based Malaria Vaccine Operation. An advisory board of international experts in vaccinology, malariology and field trials provides the scientific oversight to support the operation. This article discusses the rationale for the approach, underlying concepts and the pre-clinical development process, and provides a brief outline of the plans for the clinical testing of a multistage, multiantigen malaria vaccine based on DNA plasmid immunization technology.
authors.affiliation: Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA. kumars@nmrc.navy.mil
authors.forename: Sanjai
authors.initials: S
authors.lastname: Kumar
authors.forename: Judith E
authors.initials: JE
authors.lastname: Epstein
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Richie
authors.forename: Francis K
authors.initials: FK
authors.lastname: Nkrumah
authors.forename: Lorraine
authors.initials: L
authors.lastname: Soisson
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Carucci
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Hoffman
mesh_terms: D000818:Animals; D006801:Humans; D007391:International Cooperation; D017780:Malaria Vaccines / Q000008:administration & dosage* / Q000276:immunology; D016778:Malaria, Falciparum / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000276:immunology*; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D017780:Malaria Vaccines; D019444:Vaccines, DNA