title: Synthesis and notable antimalarial activity of acyclic peroxides, L-(alkyldioxy)-L-(methyldioxy)cyclododecanes.
abstract: Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).
authors.affiliation: Department of Materials Chemistry & Frontier Research Center, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hamada
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Tokuhara
authors.forename: Araki
authors.initials: A
authors.lastname: Masuyama
authors.forename: Masatomo
authors.initials: M
authors.lastname: Nojima
authors.forename: Hye-Sook
authors.initials: HS
authors.lastname: Kim
authors.forename: Kanako
authors.initials: K
authors.lastname: Ono
authors.forename: Naoki
authors.initials: N
authors.lastname: Ogura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Wataya
mesh_terms: D000473:Alkanes / Q000737:chemistry; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D003516:Cycloparaffins / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D006844:Hydrocarbons, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D016778:Malaria, Falciparum / Q000188:drug therapy; D051379:Mice; D010545:Peroxides / Q000138:chemical synthesis* / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D014407:Tumor Cells, Cultured
chemical_list: C452426:1,2-bis(methyldioxy)cyclododecane; D000473:Alkanes; D000962:Antimalarials; D003516:Cycloparaffins; D006844:Hydrocarbons, Cyclic; D010545:Peroxides; C007548:n-dodecane