Effects of rocuronium pretreatment on muscle enzyme levels following suxamethonium.
BACKGROUND
The effects of different time intervals between rocuronium pretreatment and suxamethonium administration on muscle-derived enzymes and myoglobin were evaluated.


METHODS
Fifty-two patients, aged 3-6 years, were allocated randomly to receive pretreatment of either rocuronium 1 min or 4 min, or a placebo, before suxamethonium. Serum creatine-phosphokinase (CK), lactate dehydrogenase (LDH), alanine aminotransferase, aspartate aminotransferase (AST) and myoglobin concentrations were measured before treatment and at 30 min, 6 h and 24 h after suxamethonium administration.


RESULTS
Mean serum CK and myoglobin concentrations in the rocuronium groups were significantly less than in the saline group 24 h and 30 min after suxamethonium administration, respectively (P < 0.05). There were no significant differences between the rocuronium groups. Mean LDH and AST concentrations were higher at 6 h and 24 h after suxamethonium administration compared with preadministration levels, respectively (P < 0.05).


CONCLUSIONS
We concluded that intervals of 1 min or 4 min between the rocuronium and suxamethonium administrations have the same effect on enzyme levels.
Ozlü
Onur
O
Department of Anaesthesiology, Social Security Ankara Children Hospital, Ankara, Turkey. ozlu@ato.org.tr
Eris
Senay
S
Mert
Ali
A
D000732:Androstanols; D018685:Anesthetics, Inhalation; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers; D018482:Muscle, Skeletal / Q000201:enzymology*; D009211:Myoglobin / Q000097:blood; D009467:Neuromuscular Depolarizing Agents; D011229:Preanesthetic Medication; D000077123:Rocuronium; D000077149:Sevoflurane; D013390:Succinylcholine; D013997:Time Factors
D000732:Androstanols; D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D009211:Myoglobin; D009467:Neuromuscular Depolarizing Agents; D000077149:Sevoflurane; D003402:Creatine Kinase; D013390:Succinylcholine; D000077123:Rocuronium