title: Kinetics of taurine depletion and repletion in plasma, serum, whole blood and skeletal muscle in cats.
abstract: The relationship between taurine concentrations of plasma, whole blood, serum and skeletal muscle during taurine depletion and repletion was investigated in cats, to identify the most useful indicators of taurine status. Sixteen cats were fed a purified diet containing either 0 or 0.15 g/kg taurine for 5 months. Treatments were then reversed and the taurine concentration was measured during repletion and depletion phases. Plasma taurine exhibited the fastest rate (slow component) of depletion (t 1/2 = 4.8 wk), followed by serum (5.3 wk), whole blood (6.2 wk), and skeletal muscle (11.2 wk). Whole blood taurine was the first to replete at a rate of 0.74 wk to 1/2 maximal repletion, followed by serum (2.1 wk), skeletal muscle (3.5 wk), and plasma (3.5 wk). Whole blood more closely reflected skeletal muscle taurine concentrations than plasma during depletion, while plasma taurine concentrations appear to be the most valuable predictor of skeletal muscle taurine concentrations during repletion. This study suggests that the best clinical method to evaluate the taurine status of the cat is the determination and interpretation of both plasma and whole blood taurine concentrations.
authors.affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616-8741, USA.
authors.forename: L
authors.initials: L
authors.lastname: Pacioretty
authors.forename: M A
authors.initials: MA
authors.lastname: Hickman
authors.forename: J G
authors.initials: JG
authors.lastname: Morris
authors.forename: Q R
authors.initials: QR
authors.lastname: Rogers
mesh_terms: D000818:Animals; D002415:Cats; D007700:Kinetics; D018482:Muscle, Skeletal / Q000378:metabolism*; D013654:Taurine / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D013997:Time Factors
chemical_list: D013654:Taurine