title: Pretreatment factors predicting the development of postchemotherapy nausea and vomiting in Chinese breast cancer patients.
abstract: A prospective longitudinal study was designed to assess the role of pretreatment proneness to nausea and vomiting (NV) in the development of postchemotherapy NV in a group of Chinese breast cancer patients receiving moderately highly emetogenic chemotherapy. Seventy-one chemotherapy-naive subjects participated in the study. Patients were assessed the day before chemotherapy with measurements of their anxiety level, depression, fatigue and proneness to NV, motion sickness, NV experienced in past pregnancies, history of labyrinthitis, expectation of developing NV and expectation of developing pain. Patients also completed daily assessments of frequency, duration and intensity of NV for the 7 days after chemotherapy. Regression analyses revealed that nonpharmacological factors explained part of the variance of NV, the most common predictors being a history of labyrinthitis, expectation of developing NV after chemotherapy, younger age, stage of disease, and state anxiety. The explanatory power of the models ranged from 6% to 23% of the variance of the independent variable. There were different explanatory models for acute and delayed NV. Results indicate that consideration of the role of nonpharmacological factors in the development of NV could lead to more effective management of NV induced by chemotherapy.
authors.affiliation: University of Nottingham, School of Nursing, A Floor, Medical School, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom. Alexander.Molassiotis@nottingham.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Molassiotis
authors.forename: B M C
authors.initials: BM
authors.lastname: Yam
authors.forename: H
authors.initials: H
authors.lastname: Yung
authors.forename: F Y S
authors.initials: FY
authors.lastname: Chan
authors.forename: T S K
authors.initials: TS
authors.lastname: Mok
mesh_terms: D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced*; D016387:Women's Health
chemical_list: D000970:Antineoplastic Agents