Effect of antiandrogen cyproterone acetate on the development of the antler cycle in Southern pudu (Pudu puda).
The antler cycle of pudu is similar to other cervids, but unlike most boreal deer, male Southern pudu (Pudu puda) exhibits two seasonal peaks of LH and testosterone. In that respect, pudu is similar to roe deer. Whereas the antler cycle in some deer species, such as roe deer or white-tailed deer, is very sensitive to variation of testosterone, in other cervids, such as fallow deer or reindeer, a blockade of androgens with cyproterone acetate (CA) has little or no effect on the timing of the antler casting. In order to test the sensitivity of pudu antlers to variations of androgens, CA (administered 2x weekly at 50 mg/buck) was injected intramuscularly for 3 weeks in 5 adult male pudu, starting February 19 (late summer). Four other males of similar age served as controls. The experiment was performed at the University of Concepcion, Chile, latitude 36.6 degreeS. Blood samples were taken once a week between January 19 and April 3. In CA-treated bucks, the antlers were cast approximately 3 weeks after the initiation of CA treatment and a new antler growth began almost immediately. The antlers reached about 5 cm in length, before ceasing to grow at the end of April, when they became mineralized and were subsequently polished. CA had no effect on the already declining levels of LH. Plasma levels of testosterone in controls increased from February 15, whereas in CA-treated bucks remained depresses until March 21. It is concluded that similarly to white-tailed deer, the antler cycle of Southern pudu is very sensitive to manipulation of androgen levels.
Bubenik
George A
GA
Department of Zoology, University of Guelph, Guelph, Ontario, Canada. gbubenik@uoguelph.ca
Reyes
Eugenia
E
Schams
Dieter
D
Lobos
Alejandro
A
Bartos
Ludek
L
Koerner
Fernando
F
D000726:Androgen Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000999:Antlers / Q000254:growth & development*; D017373:Cyproterone Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D003670:Deer / Q000502:physiology*; D007273:Injections, Intramuscular; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D012621:Seasons; D013739:Testosterone / Q000097:blood
D000726:Androgen Antagonists; D013739:Testosterone; D017373:Cyproterone Acetate; D007986:Luteinizing Hormone