title: The three faces of vestibular ganglionitis.
abstract: We present temporal bone and clinical evidence that common syndromes of recurrent vertigo are caused by a viral infection of the vestibular ganglion. In the present series, histopathologic and radiologic changes in the vestibular ganglion and meatal ganglion were consistent with a viral inflammation of ganglion cells in cases of Meniere's disease, benign paroxysmal positional vertigo, and vestibular neuronitis. Clinical observations of multiple neuropathies involving cranial nerves V, VII, and VIII on the same side in patients with recurrent vertigo are best explained by a cranial polyganglionitis caused by a neurotrophic virus, which is reactivated by a stressful event later in life. The reactivation of the latent virus may manifest as one of the above vertigo syndromes, depending on the part of the vestibular ganglion that is inflamed, the type and strain of the virus, and host resistance.
authors.affiliation: Department of Surgery, University of South Alabama College of Medicine, Mobile 36688-0002, USA.
authors.forename: Richard R
authors.initials: RR
authors.lastname: Gacek
authors.forename: Mark R
authors.initials: MR
authors.lastname: Gacek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005154:Facial Nerve / Q000473:pathology; D005260:Female; D017950:Ganglia, Sensory / Q000473:pathology; D005830:Geniculate Ganglion / Q000473:pathology; D006561:Herpes Simplex / Q000150:complications*; D006562:Herpes Zoster / Q000150:complications*; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000473:pathology; D008875:Middle Aged; D012008:Recurrence; D027161:Satellite Cells, Perineuronal / Q000473:pathology; D013701:Temporal Bone / Q000473:pathology; D014717:Vertigo / Q000209:etiology; D020338:Vestibular Neuronitis / Q000473:pathology / Q000821:virology*