[Immunological variants and free radical characteristics of workers exposed to epoxy resins].
Workers on exposure to epoxy resins (ER) have been shown to reveal several variants of immunogrammes of blood, expression of Fas-ligands and oxygen-dependent metabolism of phagocytes. These are as follows: the immune deficiency variant (38.1%), the autoimmune one (33.3%), the state of norm (28.6%). The blood phagocyte oxygen-dependent metabolism tends towards activation but the phagocyte functional reserve is reduced which facts suggest depression of metabolism and phagocytic defence in the organism. Identified in the study are several variants of kinetic parameters of the blood serum chemiluminescence suggesting activation/inhibition of process of free radical oxidation, strengthening/weakening of the blood antioxidant defence, which events can be regarded as early diagnostic and prognostic criteria of adverse effects of epoxy resins on the organism of those handling them. These data suggest to us an insufficient reliability of the existing maximum permissible concentration of epoxy resins in the air of the working zone and attest to the need for its reconsideration.
Iavorovskiĭ
A P
AP
Kuiun
L A
LA
Afonina
G B
GB
Paustovskiĭ
Iu A
IuA
Veremeĭ
M I
MI
D000954:Antigens, Surface / Q000276:immunology; D004853:Epoxy Resins / Q000009:adverse effects*; D053222:Fas Ligand Protein; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D014644:Genetic Variation; D006801:Humans; D007109:Immunity / Q000187:drug effects* / Q000235:genetics; D007700:Kinetics; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D010100:Oxygen / Q000378:metabolism; D010586:Phagocytes / Q000276:immunology
D000954:Antigens, Surface; D004853:Epoxy Resins; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D005609:Free Radicals; D008562:Membrane Glycoproteins; D010100:Oxygen