[Hyperinsulinemia and insulin resistance in pathogenesis of atherosclerosis and ischemic heart disease].
OBJECTIVE
To confirm the pathogenetic relationship of hyperinsulinemia, insulin resistance, and coronary disease.


METHODS
Thirty-nine coronary patients (male) were examined using lipid loading test, bicycle ergometry, coronarography, and measurements of insulin, cholesterol (CS), triglycerides (TG), very low density lipoproteins (VLDL), low density lipoproteins (LDL), high density lipoprotein (HDL) CS, apoA-1, and apoB.


RESULTS
Blood levels of CS, TG, VLDL, LDL, HDL CS, apoA-1, apoB, and insulin were measured before and 3, 6, and 9 h after lipid loading in 39 coronary patients and 20 normal subjects. Coronarography showed initially high levels of insulin in coronary patients with pronounced changes. Insulin level drastically increased after insulin loading; increases in TG and apoB levels were the most pronounced, while the concentrations of HDL CS and apoA-1 decreased and did not normalize 6 h after lipid loading.


CONCLUSIONS
The results confirmed the relationship between hyperinsulinemia, insulin resistance, and coronary disease.
Sokolov
E I
EI
D001161:Arteriosclerosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D017023:Coronary Angiography; D004041:Dietary Fats; D005080:Exercise Test; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications* / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D017202:Myocardial Ischemia / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology
D004041:Dietary Fats; D007328:Insulin; D008055:Lipids