[The patho-morphology and biological behavior of repeatedly recurrent liposarcoma in retroperitoneum].
OBJECTIVE
To investigate the patho-morphological features and biological behavior of repeatedly recurrent liposarcomas in retroperitoneum as well as the differential diagnosis with other malignant mesenchymal tumors.


METHODS
Totally 10 patients accompanied with detailed clinical data. Except HE staining, immunohistochemical assays for S-100 actin, vimentin and myoglobin were also used for 32 specimens.


RESULTS
6/8 cases of the primary and 13/24 cases of the recurrent tumors of this group were diagnosed as sclerosing liposarcoma with spindle cell proliferation arranged in fascicles and whorls. Ten retroperitoneal tumor recurred within 20 months to 10 years, and among them, distant metastasis obtained only in one case. The histologic subtypes of recurrent and metastasized tumors became varied in 5 cases.


CONCLUSIONS
Sclerosing liposarcoma was the most common histological subtype, see in retroperitoneal liposarcoma, local recurrence frequent, but distant metastasis rare. Surgical removal of the recurrent tumors might prolong the survival expectation of these patients.
Zhang
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Department of Pathology, Beijing Friendship Hospital, Beijing 100050.
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008080:Liposarcoma / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology*; D012186:Retroperitoneal Neoplasms / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis
D009418:S100 Proteins