Nuclear receptor coregulators: multiple modes of modification.
Many proteins have been characterized as coregulators that can be recruited by DNA-binding nuclear receptors to influence transcriptional regulation. Recent genetic and biochemical studies have shown that cellular levels of coregulators are crucial for nuclear receptor-mediated transcription, and many coregulators have been shown to be targets for diverse intracellular signaling pathways and post-translational modifications. This review focuses on the different modes of regulation of nuclear receptor coregulators and the implications for tissue- and context-specific transcriptional responses to hormone and membrane receptor signaling.
Hermanson
Ola
O
Department of Medicine, Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, 92093-0648, La Jolla, CA 92093-0648, USA.
Glass
Christopher K
CK
Rosenfeld
Michael G
MG
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000502:physiology*; D003593:Cytoplasm / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology; D006801:Humans; D010766:Phosphorylation; D018160:Receptors, Cytoplasmic and Nuclear / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics
D004268:DNA-Binding Proteins; D018160:Receptors, Cytoplasmic and Nuclear