title: Identification and determination of selected medicines reducing hypertension by densitometric and gas chromatographic methods.
abstract: Conditions have been elaborated for the identification and quantitative determination of captopril and enalapril in pharmaceutical preparations by the densitometric method in the concentration range 5-50 microg, and of enalapril by gas chromatography in the concentration range 0.5-3.5 mg/ml. The separation of the preparations was performed using methanol. In the densitometric method the determination of captopril was done at lambda = 212 nm, while for enalapril at lambda = 210 nm. In the gas chromatographic method a DB-17 capillary column was used as well as a flame ionization detector. Perindopril was used as the internal standard.
authors.affiliation: Department of Basic and Applied Pharmacy, Drug Institute, Warsaw, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Czerwińska
authors.forename: E
authors.initials: E
authors.lastname: Wyszomirska
authors.forename: T
authors.initials: T
authors.lastname: Kaniewska
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis*; D000959:Antihypertensive Agents / Q000032:analysis*; D002216:Captopril / Q000032:analysis; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003720:Densitometry; D004656:Enalapril / Q000032:analysis; D020913:Perindopril / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004364:Pharmaceutical Preparations; D004656:Enalapril; D002216:Captopril; D020913:Perindopril