[An experimental study of the effects of thrombin receptor activating peptide (TP508) on healing of ischemic wound and flap survival in rats].
OBJECTIVE
To investigate the effects of the thrombin receptor activating peptide (TP508) on healing of ischemic wound and flap survival in rats.


METHODS
Sixty-six Sprague-Dawley rats were employed as the model. On the back of the rats, three kinds of wound and flap were made to establish four groups as follows: partial ischemic wound in 16, full ischemic wound in 16, routine wound in 18 and flap in 16 rats. Each group was further divided into TP508 treating group and isotonic saline control group. The total and necrotic areas of the wounds and flaps were daplicated on acetate papers and calculated with a computer on the 3rd, 7th, 10th and 14th post-operation days (PODs).


RESULTS
In routine wounds, the ischemic wound area treated by TP508 was 73.7% and 45.4% in saline control groups on 7 and 14 (PODs), respectively. While in the flap model, the necrotic flap area treated by TP508 was 80.4% and 56.8% in control groups on 7 and 14 (PODs), respectively.


CONCLUSIONS
TP508 could accelerate healing of ischemic wound and improve flap survival in rats.
Huang
Y
Y
Institute of Burn Research, Southwestern Hospital, Third Military Medical University, Chongqing 400038, P. R. China.
Yang
Z
Z
Li
A
A
D000818:Animals; D004195:Disease Models, Animal; D007511:Ischemia; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000187:drug effects*
D010446:Peptide Fragments; C076901:thrombin receptor-activating peptide (P508-530)