Sustained attention in young people at high risk for schizophrenia.
BACKGROUND
Sustained attention has been found to be impaired in individuals suffering from schizophrenia and their close relatives. This has led to the hypothesis that impaired sustained attention is an indicator of vulnerability to schizophrenia.


METHODS
The Edinburgh High Risk Study used the Continuous Performance Test-Identical Pairs version (CPT-IP) to assess sustained attention in 127 high risk participants, 30 controls and 15 first-episode schizophrenic patients. A second assessment was completed by 59 high risk and 18 control participants 18 months to 2 years after the first.


RESULTS
No differences in attentional capacity were found between the high risk and control groups and there was no association between genetic liability to schizophrenia and poor performance on the CPT-IP. Additionally, no association between occurrence of psychotic symptoms in the high risk group and impaired attentional capacity was found.


CONCLUSIONS
The results suggest that deficits in sustained attention are not indicative of a genetic vulnerability to schizophrenia, and are not associated with the occurrence of psychotic symptoms.
Cosway
R
R
Department of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park.
Byrne
M
M
Clafferty
R
R
Hodges
A
A
Grant
E
E
Morris
J
J
Abukmeil
S S
SS
Lawrie
S M
SM
Miller
P
P
Owens
D G C
DG
Johnstone
E C
EC
D000328:Adult; D001288:Attention; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D004193:Discrimination Learning; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual; D011597:Psychomotor Performance; D012306:Risk; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology