Identification and determination of selected medicines reducing hypertension by densitometric and gas chromatographic methods.
Conditions have been elaborated for the identification and quantitative determination of captopril and enalapril in pharmaceutical preparations by the densitometric method in the concentration range 5-50 microg, and of enalapril by gas chromatography in the concentration range 0.5-3.5 mg/ml. The separation of the preparations was performed using methanol. In the densitometric method the determination of captopril was done at lambda = 212 nm, while for enalapril at lambda = 210 nm. In the gas chromatographic method a DB-17 capillary column was used as well as a flame ionization detector. Perindopril was used as the internal standard.
Czerwińska
K
K
Department of Basic and Applied Pharmacy, Drug Institute, Warsaw, Poland.
Wyszomirska
E
E
Kaniewska
T
T
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis*; D000959:Antihypertensive Agents / Q000032:analysis*; D002216:Captopril / Q000032:analysis; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003720:Densitometry; D004656:Enalapril / Q000032:analysis; D020913:Perindopril / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004364:Pharmaceutical Preparations; D004656:Enalapril; D002216:Captopril; D020913:Perindopril