title: Colorectal cancer in mice genetically deficient in the mucin Muc2.
abstract: The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2-/- mice displayed aberrant intestinal crypt morphology and altered cell maturation and migration. Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal cancer.
authors.affiliation: Department of Oncology, Albert Einstein Cancer Center/Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467, USA. velcich@aecom.yu.edu
authors.forename: Anna
authors.initials: A
authors.lastname: Velcich
authors.forename: WanCai
authors.initials: W
authors.lastname: Yang
authors.forename: Joerg
authors.initials: J
authors.lastname: Heyer
authors.forename: Alessandra
authors.initials: A
authors.lastname: Fragale
authors.forename: Courtney
authors.initials: C
authors.lastname: Nicholas
authors.forename: Stephanie
authors.initials: S
authors.lastname: Viani
authors.forename: Raju
authors.initials: R
authors.lastname: Kucherlapati
authors.forename: Martin
authors.initials: M
authors.lastname: Lipkin
authors.forename: Kan
authors.initials: K
authors.lastname: Yang
authors.forename: Leonard
authors.initials: L
authors.lastname: Augenlicht
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology; D000236:Adenoma / Q000737:chemistry / Q000473:pathology; D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D002455:Cell Division; D019070:Cell Lineage; D002465:Cell Movement; D003106:Colon / Q000737:chemistry / Q000166:cytology / Q000473:pathology; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D003598:Cytoskeletal Proteins / Q000032:analysis; D018450:Disease Progression; D004379:Duodenal Neoplasms / Q000737:chemistry / Q000473:pathology; D004386:Duodenum / Q000737:chemistry / Q000166:cytology / Q000473:pathology; D004847:Epithelial Cells / Q000737:chemistry / Q000502:physiology; D005260:Female; D018390:Gene Targeting; D020397:Goblet Cells / Q000166:cytology; D007413:Intestinal Mucosa / Q000737:chemistry / Q000166:cytology / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D055262:Mucin-2; D009077:Mucins / Q000032:analysis / Q000235:genetics* / Q000502:physiology*; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis; D015534:Trans-Activators; D051176:beta Catenin
chemical_list: C495267:CTNNB1 protein, mouse; D003598:Cytoskeletal Proteins; C524626:Muc2 protein, mouse; D055262:Mucin-2; D009077:Mucins; D016271:Proto-Oncogene Proteins c-myc; D015534:Trans-Activators; D051176:beta Catenin