[Effects of synthetic interleukin-1 blockers on uveitis in rats].
OBJECTIVE
To investigate the therapeutic action of synthetic interleukin-1 blockers on uveitis in rats.


METHODS
Experiments were performed on 18 Spraque-Dawley rats (36 eyes), and the retinal interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) were quantified by an enzyme-linked immunoabsorbent assay (ELISA) before and after the rats with uveitis treated by synthetic interleukin-1 blockers.


RESULTS
The retinal IL-1 beta and TNF-alpha in rats with uveitis treated by synthetic IL-1 blockers (CK-138, 139) were significantly decreased than those treated by contrasting design.


CONCLUSIONS
Synthetic IL-1 blockers (CK-138, 139) are effective in treatment of IL-1 alpha induced uveitis in the rat.
Zhou
Y
Y
Department of Ophthalmology, Tong Ren Hospital, The Capital University of Medical Sciences, Beijing 100730, China.
Li
Z
Z
An
W
W
Chiou
G
G
D000818:Animals; D005260:Female; D007375:Interleukin-1 / Q000032:analysis / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D014605:Uveitis / Q000188:drug therapy* / Q000209:etiology
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha