title: Cretinism in a North American black bear (Ursus americanus).
abstract: Congenital hyperplastic goiter and cretinism were documented in a 16 month-old male North American black bear (Ursus americanus). The cub was captured at approximately 8 months of age and maintained for an additional 8 months in captivity. Clinical signs included growth retardation, clumsiness, and facial dysmorphism. Hypothyroidism was documented by determining serum triiodothyronine (T3) and thyroxine (T4) levels. Lysosomal storage disease was ruled out by measuring various lysosomal enzyme activities. Serologic, radiographic, computed tomographic, necropsy, and histopathologic findings were consistent with congenital hypothyroidism and cretinism.
authors.affiliation: Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. duncanr@vt.edu
authors.forename: Robert B
authors.initials: RB
authors.lastname: Duncan
authors.forename: Jeryl C
authors.initials: JC
authors.lastname: Jones
authors.forename: H David
authors.initials: HD
authors.lastname: Moll
authors.forename: Martha M
authors.initials: MM
authors.lastname: Moon
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Blodgett
authors.forename: Michael R
authors.initials: MR
authors.lastname: Vaughan
mesh_terms: D000818:Animals; D003409:Congenital Hypothyroidism / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D007037:Hypothyroidism / Q000000981:diagnostic imaging / Q000662:veterinary*; D008297:Male; D014057:Tomography, X-Ray Computed; D001503:Ursidae