title: Two cases of Sjögren's syndrome with multiple bullae.
abstract: Here, we report two rare female cases of Sjögren's syndrome with multiple bullae, involving a 66- and a 51-year-old. Neither had any obvious pulmonary complaint. Chest radiographs and high-resolution CT (HRCT) scans showed interstitial linear and nodular opacities and multiple bullae. In the first case spirometry indicated an obstructive change judged by FEV1.0 and V50/V25. In both cases, histologic examination of the lung revealed thickening of alveolar septa and interstitial mononuclear cell infiltration. In the first case the bullae decreased in size with corticosteroid treatment. Airway narrowing due to peribronchiolar mononuclear cell infiltration causes a check-valve mechanism, which may lead to bullae formation. Although a rare occurrence, it is important to recognize that cystic or bullous lung disease can accompany Sjögren's syndrome.
authors.affiliation: First Department of Internal Medicine, Kumamoto University School of Medicine.
authors.forename: Osamu
authors.initials: O
authors.lastname: Sakamoto
authors.forename: Naoki
authors.initials: N
authors.lastname: Saita
authors.forename: Makoto
authors.initials: M
authors.lastname: Ando
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Kohrogi
authors.forename: Moritaka
authors.initials: M
authors.lastname: Suga
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ando
mesh_terms: D000368:Aged; D000402:Airway Obstruction / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D001327:Autoimmune Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D001768:Blister / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D006984:Hypertrophy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011650:Pulmonary Alveoli / Q000473:pathology; D012859:Sjogren's Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D013147:Spirometry; D014057:Tomography, X-Ray Computed
chemical_list: D007166:Immunosuppressive Agents; D011239:Prednisolone