[Lipid disturbance of cell membranes in the etiopathogenesis of schizophrenia and affective disorders].
The authors present information on the key role of lipid disturbances (mainly phospholipids) of neural membranes in the etiopathogenesis of schizophrenia and affective disorders. Current theories on membrane phospholipid disturbances in the etiopathogenesis of schizophrenia and affective disorders are connected to the idea that the primary metabolic disorder in both these disorders is due to the altered activity of phospholipase AZ, which in turn brings about disturbances in other lipid elements. Especially the functional insufficiency of some necessary fatty acids, as well as disturbed prostaglandin secretion has been shown in these disorders. In the recent years evidence has been collected on the action of pharmacologic substances used in these disorders on the lipid enzyme metabolism.
Lewandowski
P
P
Kliniki Psychiatrii Dorosłych AM w Poznaniu.
Rybakowski
J
J
D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D019964:Mood Disorders / Q000201:enzymology*; D009474:Neurons / Q000378:metabolism* / Q000648:ultrastructure; D010740:Phospholipases / Q000378:metabolism*; D012559:Schizophrenia / Q000201:enzymology*
D010740:Phospholipases