title: [The inhibitory effect of CLA on mice forestomach neoplasia induced by B(a)P].
abstract: OBJECTIVE
  To study the inhibitory effect of CLA on the postinitiation phase of forestomach neoplasia formation induced by B(a)P and explore its possible mechanism of anticarcinogenesis.
  
  
  METHODS
  Kunming mice were divided into five groups, i.e. salad oil control group, CLA control group, B(a)P group, B(a)P + high dose CLA group and B(a)P + low dose CLA group. The experimental period was 23 weeks, and the endpoints included cell proliferation, expression of Pan-ras P21 and some enzymes.
  
  
  RESULTS
  Short term CLA treated significantly inhibited the forestomach neoplasia formation induced by B(a)P at postinitiation phase. The incidence of tumor in the groups of B(a)P, B(a)P + high dose CLA and B(a)P + low dose CLA was 100%, 60% and 69% respectively (P < 0.05). The possible mechanism of this anticarcinogenic effect may be related to the inhibition of cell proliferation and the induction of the activities of GSH-Px, GST and SOD, irrespective of the regulation of expression of Pan-ras P21.
  
  
  CONCLUSIONS
  CLA is a promising chemopreventive agent, and its anticarcinogenic effect may involve its effects on the redox system.
authors.affiliation: Public Health College, Harbin Medical University, Haerbin 150001, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
authors.forename: J
authors.initials: J
authors.lastname: Qiou
authors.forename: B
authors.initials: B
authors.lastname: Chen
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001564:Benzo(a)pyrene / Q000633:toxicity*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D019787:Linoleic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000201:enzymology; D051379:Mice; D015689:Oncogene Protein p21(ras) / Q000032:analysis; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D016588:Anticarcinogenic Agents; D001564:Benzo(a)pyrene; D019787:Linoleic Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D015689:Oncogene Protein p21(ras)