title: Strategies for selecting antibiotics in intensive care units.
abstract: Crowding of severely ill patients in intensive care units has led worldwide to important increases in nosocomial (ICU-related) infections. Moreover, the nature of these hospital-acquired infections is shifting towards Gram-positive microorganisms, yeast and Gram-negative rods, possessing important resistance genes (e.g. extended spectrum beta-lactamases and inducible Enterobacteriaceae). Ceftazidime and aztreonam are loosing their activity against the Gram-negative microorganisms. The fourth generation cephalosporins have an intrinsic high activity against the inducible Enterobacteriaceae. On our Hematology and Intensive Care units, the introduction of cefepime for nosocomial infections led to a remarkable drop in the number of Enterobacter isolates combined with important decreases in Enterobacter resistance towards several antibiotics.
authors.affiliation: Departments of Intensive Care.
authors.forename: Hendrik E.
authors.initials: HE
authors.lastname: Demey
authors.forename: Hilde
authors.initials: H
authors.lastname: Jansens
authors.forename: Frank
authors.initials: F
authors.lastname: Van Laer
authors.forename: Margareta
authors.initials: M
authors.lastname: Ieven
authors.forename: Herman
authors.initials: H
authors.lastname: Goossens
authors.forename: Leo L.
authors.initials: LL
authors.lastname: Bossaert