title: Diverse roles for the LDL receptor family.
abstract: The low-density lipoprotein (LDL) receptor family consists of several related scavenger receptors that not only function as important cargo transporters, but also inform the cell of changes in its environment by mediating signaling responses. The LDL receptor was the first family member to be characterized and its function seems to be restricted to lipoprotein metabolism. By contrast, lipoprotein metabolism does not appear to be the exclusive function of the other characterized LDL receptor family members. It is now apparent that cargo transport by members of the LDL receptor family is closely associated with regulation of cellular physiology and cellular signaling events. Here, we focus on the diverse biological activities of certain members of this family.
authors.affiliation: Department Vascular Biology, Holland Laboratory, American Red Cross, Rockville, MD 20855, USA. strickla@usa.redcross.org
authors.forename: Dudley K
authors.initials: DK
authors.lastname: Strickland
authors.forename: Steven L
authors.initials: SL
authors.lastname: Gonias
authors.forename: W Scott
authors.initials: WS
authors.lastname: Argraves
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D006801:Humans; D011973:Receptors, LDL / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D011973:Receptors, LDL