Treatment of steroid-resistant idiopathic thrombocytopenic purpura in pregnancy with repeated high-dose intravenous immunoglobulin.
High-dose intravenous immunoglobulin (HD-IVIG) has temporary but reliable efficacy in idiopathic thrombocytopenic purpura (ITP). HD-IVIG has been described as the representative management in pregnant cases of refractory to corticosteroid or immunosuppressants. There have been few cases treated with repeated HD-IVIG to sustain pregnancy from the early phase of pregnancy. This case report describes a pregnant case of steroid-refractory ITP, treated with six times repeated HD-IVIG, resulting in the successful delivery of a healthy newborn with a normal platelet count. No adverse effects were observed.
Kimura
S
S
Division of Hematology, Kyoto Second Red Cross Hospital, Japan.
Kuroda
J
J
Akaogi
T
T
Hayashi
H
H
Ogino
Y
Y
Kobayashi
Y
Y
Yoshikawa
T
T
D000293:Adolescent; D002585:Cesarean Section; D002908:Chronic Disease; D004351:Drug Resistance; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*; D013256:Steroids
D016756:Immunoglobulins, Intravenous; D013256:Steroids