New insights in chronic allograft rejection.
Chronic allograft nephropathy remains the main cause of renal graft failure. Immunologic mechanisms seem mostly responsible for the injury and subsequent fibrogenic tissue response while nonimmune mechanisms act mostly as progression factors. In this article, these factors are reviewed along with the changes that take place in the graft and new insights into possible therapeutic strategies.
Paul
Leendert C
LC
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. lcpaul@lumc.nl
D000818:Animals; D000917:Antibody Formation / Q000502:physiology; D065095:Calcineurin Inhibitors; D002908:Chronic Disease; D006084:Graft Rejection / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects; D012307:Risk Factors; D013601:T-Lymphocytes / Q000502:physiology
D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents