title: Modulation of 5-fluorouracil/leucovorin by trimetrexate--did it work?
authors.forename: J R
authors.initials: JR
authors.lastname: Bertino
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D004357:Drug Synergism; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D010919:Placebos; D016032:Randomized Controlled Trials as Topic; D015996:Survival Rate; D016896:Treatment Outcome; D016597:Trimetrexate / Q000627:therapeutic use*; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D000964:Antimetabolites, Antineoplastic; D010919:Placebos; D002955:Leucovorin; D005472:Fluorouracil; D016597:Trimetrexate