title: [Effects of different nutritional support routes on the intestinal mucosa mucosainjury and renovation in burned rats].
abstract: OBJECTIVE
  To compare the effects of different nutritional support routes on the intestinal mucosa in burned rats.
  
  
  METHODS
  Wistar rats inflicted with 30% TBSA full thickness burns were employed as the model and randomly divided into three groups: burn with enteral nutrition (EN), burn with parenteral nutrition (PN), and normal control (C). Solutions for intravenous and oral application with same volume, calorie, nitrogen and other nutrients were administered to rats in PN and EN groups, respectively. The plasma diamine oxidase (DAO) activity, the intestinal mucosa change of proliferating cell nuclear antigen (PCNA), of transmembrane electric potential difference (PD), of intestinal trefoil factor and their correlation analysis (ITF) were observed.
  
  
  RESULTS
  Plasma DAO activity increased obviously and PD, PCNA values, ITF content were much lower in EN, PN groups than those in C group. The ITF content, the values of PD and PCNA in EN were much higher than those in PN group, while DAO activity in EN group was obviously lower than that in PN group. In addition, ITF content was significantly negatively correlated to plasma DAO activity, and obviously positively correlated to PCNA and PD values. It is suggested that intestinal mucosa injury was much more severe in PN group than that in EN group.
  
  
  CONCLUSIONS
  Postburn intestine mucosa mucosal structural injury was related to the evident decrease of synthesis and secretion of ITF. Enteral nutrition might slow down the decrement of ITF, which could explain why EN was superior to PN in terms of decreasing intestinal mucosal injury and enhancing intestinal renovation.
authors.affiliation: Institute of Burn Research, Southwestern Hospital, The Third Military Medical University, Chongqing, 400038, P.R. China.
authors.forename: X
authors.initials: X
authors.lastname: Peng
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Tao
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000097:blood; D000818:Animals; D002056:Burns / Q000473:pathology / Q000503:physiopathology*; D004750:Enteral Nutrition; D005260:Female; D006133:Growth Substances / Q000032:analysis; D007413:Intestinal Mucosa / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009077:Mucins; D009124:Muscle Proteins; D009479:Neuropeptides; D010288:Parenteral Nutrition; D010455:Peptides / Q000032:analysis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3
chemical_list: D006133:Growth Substances; D009077:Mucins; D009124:Muscle Proteins; D009479:Neuropeptides; D010455:Peptides; D018809:Proliferating Cell Nuclear Antigen; C099037:TFF3 protein, rat; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D006631:Amine Oxidase (Copper-Containing)