title: Detection of measles vaccine in the throat of a vaccinated child.
abstract: Measles vaccine is widely used, most often in association with mumps and rubella vaccines. We report here the case of a child presenting with fever 8 days after vaccination with a measles-mumps-rubella vaccine. Measles virus was isolated in a throat swab taken 4 days after fever onset. This virus was then further genetically characterised as a vaccine-type virus. Fever occurring subsequent to measles vaccination is related to the replication of the live attenuated vaccine virus. In the case presented here, the vaccine virus was isolated in the throat, showing that subcutaneous injection of an attenuated measles strain can result in respiratory excretion of this virus.
authors.affiliation: Laboratory of Virology, Hospices Civils de Lyon, Domaine Rockefeller, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France. fmorfin@rockefeller.univ-lyon1.fr
authors.forename: Florence
authors.initials: F
authors.lastname: Morfin
authors.forename: Anne
authors.initials: A
authors.lastname: Beguin
authors.forename: Bruno
authors.initials: B
authors.lastname: Lina
authors.forename: Danielle
authors.initials: D
authors.lastname: Thouvenot
mesh_terms: D001483:Base Sequence; D002675:Child, Preschool; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005334:Fever / Q000209:etiology; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008458:Measles Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000235:genetics / Q000302:isolation & purification; D008459:Measles virus / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000235:genetics / Q000302:isolation & purification; D019590:Nucleocapsid Proteins / Q000235:genetics / Q000302:isolation & purification; D010614:Pharynx / Q000821:virology*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects / Q000235:genetics / Q000302:isolation & purification; D014779:Virus Replication
chemical_list: D004279:DNA, Viral; D008458:Measles Vaccine; D022542:Measles-Mumps-Rubella Vaccine; D019590:Nucleocapsid Proteins; D014613:Vaccines, Attenuated