title: Increased frequency of the C3*F allele and the Leiden mutation of coagulation factor V in patients with severe coronary heart disease who survived myocardial infarction.
abstract: The aim of the present study was to compare the frequencies of the F allele of C3 complement component and the Leiden mutation of coagulation factor V in patients with severe coronary heart disease (CHD) who survived myocardial infarction (MI; group A), and those who had no MI in their case history (group B). We have determined the C3 allele frequencies by electrophoresis, and Leiden mutation by PCR in 338 patients with severe CHD and in 490 and 523 healthy controls, respectively. The C3*F allele frequency was significantly (p = 0.006) higher in group A (0.213) that in group B (0.132). A significant (p = 0.045) difference was found between < or = 60-year group A (0.077) and group B (0.029) patients in the frequency of Leiden mutation. These findings indicate that the C3*F allele and the Leiden mutation may be associated with an increased risk of developing myocardial infarction in CHD patients.
authors.affiliation: First Department of Medicine, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Császár
authors.forename: J
authors.initials: J
authors.lastname: Duba
authors.forename: B
authors.initials: B
authors.lastname: Melegh
authors.forename: J
authors.initials: J
authors.lastname: Kramer
authors.forename: C
authors.initials: C
authors.lastname: Szalai
authors.forename: Z
authors.initials: Z
authors.lastname: Prohászka
authors.forename: I
authors.initials: I
authors.lastname: Karádi
authors.forename: M
authors.initials: M
authors.lastname: Kovács
authors.forename: K
authors.initials: K
authors.lastname: Méhes
authors.forename: L
authors.initials: L
authors.lastname: Romics
authors.forename: G
authors.initials: G
authors.lastname: Füst
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003176:Complement C3 / Q000235:genetics*; D003327:Coronary Disease / Q000097:blood* / Q000150:complications / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009203:Myocardial Infarction / Q000097:blood* / Q000209:etiology / Q000235:genetics*; D012307:Risk Factors
chemical_list: D003176:Complement C3; C095381:factor V Leiden; D005165:Factor V