title: [Apraclonidine prevents the acute increase of intraocular pressure in brown eyes with Nd:YAG laser iridectomy].
abstract: OBJECTIVE
  To investigate if apraclonidine can effectively prevent the acute increase of intraocular pressure (IOP) in brown eyes with Nd:YAG laser iridectomy.
  
  
  METHODS
  48 eyes with primary angle closure glaucoma were divided into treatment and control groups, which were matched by age and sex. One drop of apraclonidine was applied into the conjunctival sac at one hour before laser iridectomy and immediately after laser iridectomy in treatment group, whereas one drop of antibiotic as placebo was applied in control group at the same time. IOP, pupil diameter were measured at 0.5, 1, 1.5, 2, 3.5 hours after laser iridectomy.
  
  
  RESULTS
  The maximum increase of IOP after laser iridectomy was 0.62 +/- 0.67 kPa and 1.13 +/- 0.87 kPa in treatment and control group respectively, there was a significant difference (P = 0.03). The obvious decrease of IOP occurred at 0.5, 1 and 1.5 hours after laser iridectomy in treatment group. No ocular and systemic side effects were found in treatment group, except pupil diameter was obviously larger in treatment group than that in control group.
  
  
  CONCLUSIONS
  1% apraclonidine effectively prevents the acute increase of IOP in brown eyes with Nd:YAG laser iridectomy.
authors.affiliation: Department of Ophthalmology, Eye Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730.
authors.forename: J
authors.initials: J
authors.lastname: Zhao
authors.forename: J
authors.initials: J
authors.lastname: Mao
authors.forename: X
authors.initials: X
authors.lastname: Liu
mesh_terms: D003000:Clonidine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D032801:Iridectomy / Q000009:adverse effects*; D053685:Laser Therapy / Q000009:adverse effects*; D008297:Male; D009798:Ocular Hypertension / Q000517:prevention & control*
chemical_list: C016986:apraclonidine; D003000:Clonidine