title: Rapidly progressive fibrosing cholestatic hepatitis--hepatitis C virus in HIV coinfection.
abstract: Fibrosing cholestatic hepatitis (FCH) is a severe and progressive form of liver dysfunction seen in organ transplant recipients infected with hepatitis B virus or hepatitis C virus (HCV) and has been attributed to cytopathic liver injury. To date, no case of FCH due to HCV has been reported in HIV-positive individuals. We describe two cases of HCV-induced FCH in two patients coinfected with HIV, culminating in rapidly progressive liver failure and death. Histological features and progression in both cases were not consistent with drug effect or obstruction. Late institution of interferon-based therapy was ultimately unsuccessful. The HCV RNA was not markedly elevated in these cases, suggesting that the cytopathic effect of HCV in these patients was not simply a consequence of viral load. FCH may in part explain the accelerated development of cirrhosis previously observed among coinfected patients. Clinicians should remain vigilant for FCH in the HIV/HCV population and consider antiviral treatment in this setting.
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Rosenberg
authors.forename: James J
authors.initials: JJ
authors.lastname: Farrell
authors.forename: Diane R
authors.initials: DR
authors.lastname: Abraczinskas
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Graeme-Cook
authors.forename: Jules L
authors.initials: JL
authors.lastname: Dienstag
authors.forename: Raymond T
authors.initials: RT
authors.lastname: Chung
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D002780:Cholestasis, Intrahepatic / Q000150:complications / Q000473:pathology*; D018450:Disease Progression; D017809:Fatal Outcome; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis*; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index