Cytotoxic withanolides from Acnistus arborescens.
Three cytotoxic withanolides, two with new structures, were isolated from the leaves of Acnistus arborescens and their structures determined by a combination of 1D and 2D NMR, mass spectral, and molecular modeling studies. Dereplication analysis of the ethyl ether extract was useful for evaluating the components showing significant cytotoxic activity.
Minguzzi
Sandro
S
Instituto de Química, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.
Barata
Lauro E S
LE
Shin
Young Geun
YG
Jonas
Patrick F
PF
Chai
Hee Byung
HB
Park
Eun Jung
EJ
Pezzuto
John M
JM
Cordell
Geoffrey A
GA
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D004852:Epoxy Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000096:biosynthesis / Q000187:drug effects; D010840:Phytosterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019657:Solanaceae / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D007783:Lactones; D010840:Phytosterols; D016660:NAD(P)H Dehydrogenase (Quinone)