[Direct effects of fluoride on activities of bone morphogenetic protein].
OBJECTIVE
To demonstrate the direct effects of fluoride on activities of bone morphogenetic protein (BMP).


METHODS
A complex sample containing BMP and sodium fluoride was implanted under the abdominal skin of young male Wistar rats. The histological characteristics, and activities of alkaline phosphatase and acid phosphatase of the implanted were examined to study the effects of fluoride on biological activities of BMP.


RESULTS
More fibroblasts cell were transformed to osteoblasts cell in animals treated by BMP with fluoride than those treated by BMP only. During bone formation induced by BMP, fluoride increased the activities of osteoblasts and accelerate mineralization, while inhibited the activities of osteoclast.


CONCLUSIONS
Fluoride can affect biological activities of BMP directly.
Xu
S
S
Institute of Environmental Medicine, Tongji Medical University, Wuhan 430030, China.
Zheng
G
G
Li
M
M
Shu
B
B
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D004343:Drug Implants; D004347:Drug Interactions; D005347:Fibroblasts / Q000187:drug effects; D008297:Male; D010006:Osteoblasts / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012969:Sodium Fluoride / Q000494:pharmacology*
D019485:Bone Morphogenetic Proteins; D004343:Drug Implants; D012969:Sodium Fluoride; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase