Asymmetric total synthesis of (+)-brefeldin A from (S)-lactate by triple chirality transfer process and nitrile oxide cycloaddition.
A novel synthesis of (+)-brefeldin A (1) has been accomplished on the basis of triple chirality transfer methodology, intramolecular ester enolate alkylation, and both intra- and intermolecular nitrile oxide cycloaddition strategies.
Kim
Deukjoon
D
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, San 56-1, Shillim-Dong, Kwanak-Ku, Seoul 151-742, Korea. deukjoon@plaza.snu.ac.kr
Lee
Jongkook
J
Shim
Phil Jong
PJ
Lim
Joong Inn
JI
Jo
Hyunil
H
Kim
Sanghee
S