title: Preliminary X-Ray Investigations Into NSAID-Binding to Cyclooxygenase-1.
abstract: The prostaglandin H synthase structure reveals a fold similar to those of other heme peroxidases, but within this fold a second active site has evolved which catalyzes the cyclooxygenase reaction. The protein has also acquired two additional domains: a membrane-binding motif that mediates the protein's monotopic attachment to the membrane, and an epidermal growth factor-like module which is found just before the membrane-binding motif and is located in the dinner interface.
authors.affiliation: Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, USA.
authors.forename: R. Michael
authors.initials: RM
authors.lastname: Garavito
authors.forename: Daniel
authors.initials: D
authors.lastname: Picot
authors.forename: Patrick J.
authors.initials: PJ
authors.lastname: Loll