Gut intraepithelial lymphocyte development.
CD8alphabeta(+) and CD4(+) intraepithelial lymphocytes, the progeny of double-positive thymocytes, are oligoclonal T-cell populations that have accumulated in the gut wall as the result of repeated antigenic stimulations, which lead to rounds of traffic through the lymph/blood circuit ending in an alpha4beta7-integrin-driven homing all along the gut mucosa. In contrast, CD8alphaalpha(+) intraepithelial lymphocytes, which may be TCRgammadelta(+) or alphabeta(+), result in part from local differentiation in the gut, but studies comparing euthymic and athymic mice suggest a thymic double-negative origin for many of them.
Guy-Grand
Delphine
D
Unité de Biologie Moléculaire du Gène, INSERM (Institut National de la Santé et de la Recherche Médicale) U277 and Institut Pasteur, Paris, France. guygrand@pasteur.fr
Vassalli
Pierre
P
D000818:Animals; D016827:CD8 Antigens / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology*; D006801:Humans; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology* / Q000502:physiology; D010581:Peyer's Patches / Q000166:cytology / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D013601:T-Lymphocytes / Q000166:cytology / Q000502:physiology*; D013897:Thoracic Duct / Q000166:cytology / Q000502:physiology
D016827:CD8 Antigens; C409469:CD8 antigen, alpha chain; D011948:Receptors, Antigen, T-Cell