title: [Administration of aggregated beta-amyloid peptide (25-35) causes change in long-term potentiation in the hippocampus].
abstract: A month after intracerebroventricular injection of aggregated beta-amyloid fragment 25-35 (7.5 nmol/ventricle), a significant change in in vivo long-term potentiation in hippocampus was demonstrated. The time course of the long-term potentiation was compared with that in sham-operated animals, a powerful and stable increase in the evoked potential amplitude was observed. This phenomenon can be related with the oxidative stress that was revealed in this model in our previous studies, and, as a consequence, with deterioration of ion homeostasis.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
authors.forename: V V
authors.initials: VV
authors.lastname: Trubetskaia
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Stepanichev
authors.forename: M V
authors.initials: MV
authors.lastname: Onufriev
authors.forename: N A
authors.initials: NA
authors.lastname: Lazareva
authors.forename: V A
authors.initials: VA
authors.lastname: Markevich
authors.forename: N V
authors.initials: NV
authors.lastname: Guliaeva
mesh_terms: D016229:Amyloid beta-Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35)