[Changes in lipid metabolism in platelet membranes in patients with ischemic heart disease following meals with animal and vegetable fats].
OBJECTIVE
To evaluate changes in oxidative lipid metabolism in platelet membranes by content of lipid peroxidation (LPO) products and antioxidant defense (AOD) activity in patients with stable chronic ischemic heart disease (IHD) after single intake of animal fat or vegetable oil.


METHODS
30 IHD patients with stable angina of effort functional class II-III and 30 healthy controls had a single meal with animal fat or vegetable oil. Before the meal and 6 hours after it tests were performed for LPO activity and AOD in platelet membranes.


RESULTS
Patients with stable chronic IHD showed LPO activation and suppressed enzymatic and non-enzymatic AOD. Single animal fat or vegetable oil intake cause insignificant shifts in oxidative platelet metabolism in healthy controls while animal fat in IHD patients activates LPO and promotes accumulation of initial and end peroxidation products in platelet membranes. Vegetable fat in IHD patients suppresses enzyme AOD.


CONCLUSIONS
Animal fat and vegetable oil as a single diet load have a prooxidant effect at the levels of platelet membranes in IHD patients but not in healthy persons.
Medvedeva
I V
IV
Dorodneva
E F
EF
Kogan
E Z
EZ
Zhuravleva
T D
TD
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005215:Fasting; D005227:Fatty Acids; D006801:Humans; D015227:Lipid Peroxidation; D008563:Membrane Lipids / Q000097:blood / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000097:blood / Q000378:metabolism*; D010084:Oxidation-Reduction; D010938:Plant Oils; D000074242:Sunflower Oil
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D008563:Membrane Lipids; D010938:Plant Oils; D000074242:Sunflower Oil