A genome-wide linkage analysis of orchard grass-sensitive childhood seasonal allergic rhinitis in Japanese families.
Seasonal allergic rhinitis (SAR) is an inflammatory disease of the nose and eyes that follows sensitization to air-born pollens. We conducted a genome-wide linkage screening of 48 Japanese families (188 members) with orchard grass (OG)-sensitive SAR children (67 affected sib-pairs) in a farming community in central Japan where OG was planted for apple farming and OG pollen is a major cause of SAR. We used the GENEHUNTER program to performed nonparametric multipoint linkage analysis for OG-sensitive SAR as a qualitative trait and for log total serum IgE levels and OG-RAST IgE levels as quantitative traits. Genotyping data of 400 microsatellite markers suggested linkage of SAR to chromosomes 1p36.2, 4q13.3, and 9q34.3 (P < 0.001), linkage of serum total IgE levels to 3p24.1, 5q33.1, 12p13.1, and 12q24.2 (P < 0.001), and linkage of OG-RAST IgE levels to 4p16.1, 11q14.3, and 16p12.3 (P < 0.001). Weak evidence for linkage of SAR to 5q33.1 was also observed (P = 0.01). All these regions, with the exception of 9q34.3, have been previously reported to be linked to asthma and/or atopy. These data suggest that, although loci linked to SAR are likely to be common to asthma, a strong contribution by specific gene(s) to OG-sensitive SAR is unlikely.
Yokouchi
Y
Y
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.
Shibasaki
M
M
Noguchi
E
E
Nakayama
J
J
Ohtsuki
T
T
Kamioka
M
M
Yamakawa-Kobayashi
K
K
Ito
S
S
Takeda
K
K
Ichikawa
K
K
Nukaga
Y
Y
Matsui
A
A
Hamaguchi
H
H
Arinami
T
T
D000293:Adolescent; D000485:Allergens / Q000276:immunology; D002648:Child; D005260:Female; D008040:Genetic Linkage; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007564:Japan; D008297:Male; D018895:Microsatellite Repeats; D009679:Nuclear Family; D010375:Pedigree; D006109:Poaceae / Q000276:immunology*; D011058:Pollen / Q000276:immunology; D019655:Quantitative Trait, Heritable; D006255:Rhinitis, Allergic, Seasonal / Q000235:genetics* / Q000276:immunology
D000485:Allergens; D007073:Immunoglobulin E