Successful treatment of cisplatin overdose with plasma exchange.
We report a 48-year-old man with laryngeal cancer who received a massive cisplatin toxic overdose without intravenous prehydration through an error in prescription. He received 400 mg/m(2) of cisplatin over a 4-day period. On day 4, he exhibited a broad range of cisplatin toxicities and emergency plasma exchange was started. From day 5 through 19, he underwent 9 cycles of plasma exchange and his plasma cisplatin concentration decreased from 2,470 ng/ml to 216 ng/ml. He completely recovered without any sequelae. No previous reports exist in the English literature of survival without complication after the administration of such a high cisplatin dosage without prehydration.
Choi
Jae Hyuck
JH
Department of Internal Medicine, College of Medicine, Pochon CHA University, Kyungkido, Korea.
Oh
Jane C
JC
Kim
Kang Ho
KH
Chong
So Young
SY
Kang
Myoung Seo
MS
Oh
Do Yeun
DY
D000970:Antineoplastic Agents / Q000506:poisoning*; D002945:Cisplatin / Q000506:poisoning*; D062787:Drug Overdose / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange
D000970:Antineoplastic Agents; D002945:Cisplatin