[The effect of defibrase in prevention of experimental atherosclerosis in rabbits].
OBJECTIVE
To study the anti-atherosclerosis effect of difibrase in rabbits.


METHODS
Use of computer, light microscope, electron microscope, biochemistry and histochemical methods to identify the total cholesterol (TC) content, mean plaque area in aorta and its cholesterol content, degree of stenosis of coronary arteries of the experimental animals and control animals.


RESULTS
Defibrase could decrease the mean plaque area of aorta and the TC content in the experimental animal group was less than that in the control group (P < 0.01). The findings in aortic arches and thoracic aorta were similar to those in the aorta (P < 0.05, P < 0.01). The number of plaques at the small artery openings in the thoracic aorta and abdominal aorta of the experimental group were less than that of the control group (P < 0.01). The cross sections made at the upper third of all hearts showed that the degree of stenosis of coronary artery branches in the heart wall of the experimental group was much less than that of the control group.


CONCLUSIONS
Defibrase can significantly inhibit atherosclerosis.
Tang
Y
Y
Laboratory of Oncology and Hematology, Navy General Hospital, Beijing 100037.
Liu
C
C
Li
C
C
Li
W
W
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D012103:Batroxobin / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D013997:Time Factors
D002791:Cholesterol, Dietary; D005343:Fibrinolytic Agents; D002784:Cholesterol; D012103:Batroxobin