title: [Mammary carcinoma arising in microglandular adenosis: a case report].
abstract: Microglandular adenosis is an uncommon benign breast entity considered as a variant form of adenosis. The diagnosis is frequently made by the pathologist as it is often clinically asymptomatic. Carcinoma arising in microglandular adenosis is very uncommon. We report a case of carcinoma arising in microglandular adenosis in a 54-year-old woman. The immunohistochemical profile, especially S100 protein expression and absence of epithelial membrane antigen, was useful to recognize the microglandular adenosis and the carcinoma of alveolar architecture, while invasion was suggested by the basement membrane disruption highlighted with anti-collagen IV immunostaining. The good prognosis of carcinoma associated with microglandular adenosis points out the importance of distinguishing this lesion from other breast carcinomas.
authors.affiliation: Service d'Anatomie Pathologique, Institut Paoli-Calmettes, 232 Boulevard de Sainte-Marguerite 13009 Marseille, France.
authors.forename: E
authors.initials: E
authors.lastname: Charafe-Jauffret
authors.forename: J
authors.initials: J
authors.lastname: Jacquemier
authors.forename: B
authors.initials: B
authors.lastname: Lelong
authors.forename: P
authors.initials: P
authors.lastname: Meynard
authors.forename: M P
authors.initials: MP
authors.lastname: Mathoulin-Portier
authors.forename: G
authors.initials: G
authors.lastname: Houvenhaegel
authors.forename: J
authors.initials: J
authors.lastname: Hassoun
mesh_terms: D001485:Basement Membrane / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology*; D024141:Collagen Type IV / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005348:Fibrocystic Breast Disease / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011379:Prognosis; D009418:S100 Proteins / Q000032:analysis
chemical_list: D024141:Collagen Type IV; D009418:S100 Proteins