Steroid 19,B-dinor-8,10-iso-analogues.
The Birch reduction of 3-methoxy-B-nor-8-isoestra-1,3,5(10)-trienes followed by acid hydrolysis produces steroid androgen 19,B-dinor-8,10-iso-analogues. By means of X-ray analysis and correlation NMR spectroscopy of 16,16-dimethyl-D-homo-19,B-dinor-8-isotestosterone, C(20)H(30)O(2), it is demonstrated that the main conformations in the crystal and in solution for two 19,B-dinor-8,10-iso-analogues are, in general, the same.
Egorov
Maxim Sergeevitch
MS
Department of Chemistry, St Petersburg State University, Universitetskii prospekt 2, 198904 St Petersburg, Russia. maxim.egorov@paloma.spbu.ru
Starova
Galina Leonidovna
GL
Shavva
Alexandr Grigorievitch
AG
D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D009654:Norsteroids / Q000737:chemistry*; D013739:Testosterone / Q000031:analogs & derivatives / Q000737:chemistry*; D045165:Testosterone Congeners / Q000138:chemical synthesis*
C455527:16,16-dimethyl-D-homo-19,B-dinor-8-isotestosterone; D009654:Norsteroids; D045165:Testosterone Congeners; D013739:Testosterone