Cutaneous consequences of photodynamic therapy.
Photodynamic therapy (PDT) has several cutaneous complications: photosensitivity is well known, but the other complications are rarely reported, Since late 1997, we have studied the dermatologic complications of using porfimer sodium PDT to treat either Barrett esophagus with high-grade dysplasia or gastroesophageal cancer in 72 consecutive patients. Cutaneous complications of PDT included serious phototoxicity requiring oral corticosteroid treatment (22 patients; 31%), herpes zoster (HZ) requiring hospitalization and intravenous antiviral treatment (1 patient; 1%), and erythema multiforme drug reaction related to porfimer sodium (1 patient; 1%). PDT-associated dermatologic complications were common and were not related to cutaneous photosensitivity.
Wolfsen
Herbert C
HC
Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32224, USA. pdt@mayo.edu
Ng
Christine S
CS
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000188:drug therapy / Q000473:pathology; D017484:Dermatitis, Phototoxic / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000473:pathology; D005148:Facial Dermatoses / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006229:Hand Dermatoses / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects* / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology