title: Evidence for an N-glycosylation polymorphism of arylsulfatase a predisposing to alcoholism in Koreans.
abstract: This study investigated the possible effect of the pseudodeficient N-glycosylation polymorphism of the arylsulfatase A (ASA) gene on alcohol dependence among Koreans. Alcoholic patients (N=123) were more likely than control subjects to be heterozygous or homozygous for the ASA pseudodeficient N-glycosylation site (36% of alcoholics versus 20% of controls; P<0.01). Among these 123 alcoholic patients, 42 alcoholics were heterozygous and two were homozygous for the ASA pseudodeficient N-glycosylation polymorphism. This result provides evidence that the ASA pseudodeficient N-glycosylation site allele increases the risk of alcohol dependence within a Korean population.
authors.affiliation: Department of Neuropsychiatry, College of Medicine, Chungbuk National University, Chungbuk, Korea. iwchung@med.chungbuk.ac.kr
authors.forename: In-Won
authors.initials: IW
authors.lastname: Chung
authors.forename: Heon
authors.initials: H
authors.lastname: Kim
authors.forename: Sang-Ick
authors.initials: SI
authors.lastname: Lee
authors.forename: Joo-Bong
authors.initials: JB
authors.lastname: Hong
authors.forename: Yong-Dae
authors.initials: YD
authors.lastname: Kim
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Nan
authors.forename: William
authors.initials: W
authors.lastname: Sribney
authors.forename: Yong-Sik
authors.initials: YS
authors.lastname: Kim
authors.forename: Paul
authors.initials: P
authors.lastname: Manowitz
mesh_terms: D000437:Alcoholism / Q000201:enzymology / Q000235:genetics*; D001665:Binding Sites / Q000235:genetics; D002553:Cerebroside-Sulfatase / Q000235:genetics* / Q000378:metabolism; D004247:DNA / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006031:Glycosylation; D007723:Korea; D011110:Polymorphism, Genetic
chemical_list: D004247:DNA; D002553:Cerebroside-Sulfatase