[Effect of mexidol on status of conditioned reflex activity after traumatic brain damage].
Even partial hippocampal lesions in rats resulted in a disturbance of time interval determination over the course of several months (1200-1500 presentations) other complex conditioned reactions being preserved. As distinct from the control animals, the long period of failure of time interval counting was absent in rats receiving Mexidol. Continuous time conditioning took place in these animals. Due to substantial improvement of autonomic processes and emotional reactions, it was possible to present a higher number of conditioned stimuli in experiments. Mexidol seems to improve the compensatory and recovery processes after brain injuries: the impaired functions recover faster, the rate of the retrograde degeneration in the lesioned brain structures decreases, phenomena like Monakov's diaschis are not observed etc.
Mering
T A
TA
Brain Research Institute, Russian Academy of Medical Sciences, Moscow.
D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology*; D003214:Conditioning, Classical / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D010847:Picolines / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010847:Picolines; D011619:Psychotropic Drugs; C070020:emoxypine succinate