In situ analysis of solvents on breath and blood: a selected ion flow tube mass spectrometric study.
We report measurements of residual vapour levels of xylenes and trimethylbenzenes, present following a floor re-surfacing procedure, using the technique of selected ion flow tube mass spectrometry (SIFT-MS). A subject exposed to controlled amounts of xylene and mesitylene was monitored by direct breath exhalation over a 4-hour period after exposure to the volatile organic compounds (VOCs) had stopped. The headspace gases above 5 mL blood samples taken over this period were also monitored. The decays of the solvent levels with time were fitted to a two-compartment model with residence times for xylene and mesitylene of 0.37 h and 0.38 h, respectively (compartment one) and 2.5 h and 2.8 h, respectively (compartment two).
Wilson
Paul F
PF
Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
Freeman
Colin G
CG
McEwan
Murray J
MJ
Milligan
Daniel B
DB
Allardyce
Randall A
RA
Shaw
Geoffrey M
GM
D000328:Adult; D000465:Algorithms; D001555:Benzene Derivatives / Q000032:analysis; D001944:Breath Tests; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D011140:Polyurethanes / Q000032:analysis; D012997:Solvents / Q000032:analysis*; D014992:Xylenes / Q000032:analysis
D001555:Benzene Derivatives; D011140:Polyurethanes; D012997:Solvents; D014992:Xylenes; C010219:mesitylene