title: [The characteristics of bcl-2 and PCNA expression in the lens epithelium of human being].
abstract: OBJECTIVE
  To investigate the characteristics of bcl-2 (gene inhibiting apoptosis) and proliferating cell nuclear antigen (PCNA) expression and their relation to the proliferation of lens epithelium.
  
  
  METHODS
  The expression of bcl-2 and PCNA were detected by immunohistochemical streptavidin-peroxidase (SP) method.
  
  
  RESULTS
  The expression of bcl-2 and PCNA in the lens epithelium of fetus and children was higher than that of the elderly, especially in the region of the lens equator.
  
  
  CONCLUSIONS
  The over-expression of bcl-2 and PCNA in the lens epithelium of fetus and children suggests that bcl-2 and PCNA might be related to the development of cataract.
authors.affiliation: Department of Ophthalmology, Fujian Medical University, Fuzhou 350001, China.
authors.forename: J
authors.initials: J
authors.lastname: Weng
authors.forename: H
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D004847:Epithelial Cells / Q000737:chemistry* / Q000166:cytology; D005333:Fetus; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007908:Lens, Crystalline / Q000737:chemistry* / Q000196:embryology / Q000254:growth & development; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D019253:Proto-Oncogene Proteins c-bcl-2