Molecular characterization and chromosome assignment of the porcine gene COX7A1 coding for the muscle specific cytochrome c oxidase subunit VIIa-M.
The COX7A1 gene encodes a heart- and muscle-specific isoform of the subunit VIIA of cytochrome c oxidase, which is the last component of the mitochondrial electron transfer chain. Cloning and characterization of the porcine COX7A1 gene revealed a highly conserved organization with respect to other mammalian COX7A1 orthologs. The porcine gene consists of four exons spanning approximately 1.5 kb and codes for a peptide of 80 amino acids. The COX7A1 gene showed no variation between pigs from different breeds. The gene was assigned by FISH and RH-mapping to SSC 6q1.1-->q1.2 which is in agreement with previously established comparative maps.
Drögemüller
C
C
Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Germany.
Kuiper
H
H
Voss-Nemitz
R
R
Brenig
B
B
Distl
O
O
Leeb
T
T
D000818:Animals; D002875:Chromosomes / Q000235:genetics*; D003576:Electron Transport Complex IV / Q000737:chemistry* / Q000235:genetics*; D005091:Exons / Q000235:genetics; D017404:In Situ Hybridization, Fluorescence; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics; D009132:Muscles / Q000201:enzymology*; D009154:Mutation / Q000235:genetics; D020161:Physical Chromosome Mapping; D021122:Protein Subunits; D021101:Radiation Hybrid Mapping; D013552:Swine / Q000235:genetics*
D007527:Isoenzymes; D021122:Protein Subunits; D003576:Electron Transport Complex IV