[Adjuvant properties of subalin, a recombinant interferon-producing probiotic].
The adjuvant properties of subalin, a recombinant probiotic prepared from live bacteria Bacillus subtilis producing human alpha 2-interferon were studied in the scheme of its use with vaccines against parvovirus enteritis and distemper. Subalin was shown to be capable of preventing immunosuppression caused by the injection of vaccines, accelerating the formation of the antigen-specific clone of memory cells and enhancing antigen-specific immune response. The mechanisms of the adjuvant effect of subalin were considered; this effect was shown to be due to the action of interferon excreted by bacteria of B. subtilis into the lumen of the intestine. The advantages of this method of interferon supply and the prospects of using subalin preparation as adjuvant are discussed.
Beliavskaia
V A
VA
State Research Center Vecto, Koltsovo, Novosibirsk Region, Russia.
Ignat'ev
G G
GG
Cherdyntseva
N V
NV
Litviakov
N V
NV
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000284:Administration, Oral; D000818:Animals; D001412:Bacillus subtilis / Q000276:immunology*; D001685:Biological Factors / Q000008:administration & dosage* / Q000276:immunology*; D004216:Distemper / Q000517:prevention & control; D004217:Distemper Virus, Canine; D006801:Humans; D016898:Interferon-alpha / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010322:Parvoviridae Infections / Q000517:prevention & control; D017992:Parvovirus; D019936:Probiotics / Q000008:administration & dosage*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000276:immunology; D013154:Spleen / Q000276:immunology
D000276:Adjuvants, Immunologic; D001685:Biological Factors; D016898:Interferon-alpha; D011994:Recombinant Proteins; C112120:subalin