The concentration of serum transforming growth factor beta-1 (TGF-beta1) is decreased in cervical carcinoma patients.
Transforming growth factor beta-1 (TGF-beta1) is a multifunctional growth factor and known to inhibit the proliferation of epithelial cell. The relationship between serum TGF-beta1 level and the presence of cervical cancer was investigated in this study. The patients with cervical squamous cell carcinoma (SCC) had significantly lower level of serum TGF-beta1 (39.14 +/- 9.03 ng/mL; mean +/- SD) than those with myoma (49.17 +/- 9.38 ng/mL) and normal subjects (49.13 +/- 8.81 ng/mL), (p < 0.007 and p < 0.001, respectively). TGF-beta1 level was also lower in the patients with cervical intraepithelial neoplasia (CIN3) (42.07 +/- 9.38 ng/mL) than in normal controls (49.13 +/- 8.81 ng/mL) (p < 0.04). It suggested that diminution of the production of TGF-beta1 has close association with the neoplastic transformation of cervical epithelium.
Wu
Hwa-Shyi
HS
Department of Obstetrics and Gynecology, Veterans General Hospital, Taipei, Taiwan, ROC. hswu@vghtpe.gov.tw
Li
Ywan Feng
YF
Chou
Chuan-I
CI
Yuan
Chiou Chung
CC
Hung
Mei Whey
MW
Tsai
Lai Chen
LC
D002294:Carcinoma, Squamous Cell / Q000097:blood*; D002454:Cell Differentiation; D015536:Down-Regulation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008875:Middle Aged; D016212:Transforming Growth Factor beta / Q000097:blood*; D053773:Transforming Growth Factor beta1; D002583:Uterine Cervical Neoplasms / Q000097:blood*
C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1