title: FDG-PET for detection of recurrences from malignant primary bone tumors: comparison with conventional imaging.
abstract: BACKGROUND
  The aim of this study was to assess the diagnostic ability of positron emission tomography using 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG-PET) in the detection of recurrences from malignant primary bone tumors compared with conventional imaging.
  
  
  METHODS
  In 27 patients (6 osteosarcomas, 21 Ewing's sarcomas), 41 FDG-PET examinations performed for diagnosis or exclusion of recurrent disease were evaluated. Conventional imaging techniques consisted of magnetic resonance imaging of the primary tumor site, thoracic computed tomography, and Tc-99m methylene diphosphonate bone scintigraphy. The reference methods were the histopathological analysis and/or the clinical and imaging follow-up.
  
  
  RESULTS
  In 25 examinations reference methods revealed 52 sites of recurrent disease (local n = 7; distant: osseous n = 22, pulmonary n = 13, soft tissue n = 10). On an examination-based analysis FDG-PET had a sensitivity of 0.96, a specificity of 0.81 and an accuracy of 0.90. Corresponding values for conventional imaging were 1.0, 0.56 and 0.82.
  
  
  CONCLUSIONS
  The sensitivity, specificity and accuracy of FDG-PET in the detection of recurrences from osseous sarcomas are high. On an examination-based analysis, FDG-PET had a not significantly lower sensitivity in comparison with conventional imaging. However, FDG-PET showed a small advantage in the detection of osseous and soft-tissue recurrences compared with conventional imaging.
authors.affiliation: Department of Nuclear Medicine, University Hospital, Münster, Germany. franziu@uni-muenster.de
authors.forename: C
authors.initials: C
authors.lastname: Franzius
authors.forename: H E
authors.initials: HE
authors.lastname: Daldrup-Link
authors.forename: A
authors.initials: A
authors.lastname: Wagner-Bohn
authors.forename: J
authors.initials: J
authors.lastname: Sciuk
authors.forename: W L
authors.initials: WL
authors.lastname: Heindel
authors.forename: H
authors.initials: H
authors.lastname: Jürgens
authors.forename: O
authors.initials: O
authors.lastname: Schober
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology; D018213:Neoplasms, Bone Tissue / Q000175:diagnosis* / Q000473:pathology; D012008:Recurrence; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D019788:Fluorodeoxyglucose F18