Progression on metastatic neuroendocrine carcinoma from a recurrent prolactinoma: a case report.
A 54 year old man was referred to the department of neurosurgery for frontal headache and vomiting. The patient was known in the department because of previous multiple surgery for a locally invasive pituitary prolactinoma (eight years, three years, and one year previously). The neurological examination revealed a frontal mass, which adhered to the dura, suggesting a meningioma. One year later, a left temporal metastasis was removed. Three months later, the patient died, with spinal metastases, of massive lung embolism. Histology revealed a progression of adenohypophyseal prolactinoma on neuroendocrine carcinoma, with an increase in proliferating indexes and modification of hormone production. This study documents a 10 year history of a rare prolactin producing pituitary carcinoma, which metastasised via liquoral flow.
Sironi
M
M
Department of Pathology, Legnano General Hospital, Legnano, Milano, Italy.
Cenacchi
G
G
Cozzi
L
L
Tonnarelli
G
G
Iacobellis
M
M
Treré
D
D
Assi
A
A
D018278:Carcinoma, Neuroendocrine / Q000473:pathology / Q000556:secondary*; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000473:pathology*; D015175:Prolactinoma / Q000473:pathology*