Does Cytomegalovirus Play a Role in Atherosclerosis?
In vitro experiments, as well as experiments using animal models, suggest that cytomegalovirus (CMV) infection can stimulate atherosclerosis. There is also evidence that CMV stimulates the development of restenosis and transplantation-associated arteriosclerosis. Activation of arterial cells, enhancement of the inflammatory response and induction of cytokine production may all be important in mediating these effects. Further experiments, especially in animals susceptible to atherosclerosis and in patients with cardiovascular disease, will be necessary to elucidate the role of CMV, and also that of other infectious agents, in atherosclerosis.
Bruggeman
Cathrien A
CA
Department of Microbiology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands.