Azurophil granules are heterogeneous with respect to mobilization induced by different concentrations of fMLP.
Azurophil granules of neutrophils beyond their already known heterogeneity of beta-glucuronidase and myeloperoxidase enzyme contents are heterogeneous with respect to a spontaneous or low concentration (2.3 or 23 nM) of formyl-Met-Leu-Phe-induced mobilization. This suggests that the heterogeneity of azurophil granules is manifested in their functions too.
Németh
K
K
Department of Pathophysiology, Institute of Health Protection, Hungarian Defense Forces, Budapest.
Fürész
J
J
Adorjáni
E
E
Csekö
C
C
Bielik
H
H
Lakatos
S
S
D002118:Calcium / Q000494:pharmacology; D015550:Cell Degranulation / Q000187:drug effects; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000201:enzymology*; D004305:Dose-Response Relationship, Drug; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D018375:Neutrophil Activation / Q000187:drug effects*; D009504:Neutrophils / Q000201:enzymology / Q000648:ultrastructure*; D009195:Peroxidase / Q000378:metabolism
D009240:N-Formylmethionine Leucyl-Phenylalanine; C049813:N-formylmethionyl-leucyl-phenylalanyl-lysine; D009195:Peroxidase; D005966:Glucuronidase; D002118:Calcium