Synthesis and biolocalization of water-soluble sapphyrins.
The synthesis, characterization, and biolocalization properties of new, fully water-soluble sapphyrins is reported. These systems, which display light absorbing features that make them of potential interest as photodynamic therapy (PDT) sensitizers, were found to localize selectively in pancreatic carcinoma tissue in a xenographic murine model. In this model, the concentration ratios for malignant tissue to surrounding muscle tissue were found to be as high as 280 in the most favorable case. The concentrations of the water-soluble sapphyrins reported here, as well as a porphyrin control system, were determined as a function of time and tissue type.
Král
Vladimir
V
Department of Analytical Chemistry, Institute of Chemical Technology, Technická 5, 166 28 Prague, Czech Republic.
Davis
Julian
J
Andrievsky
Andrei
A
Kralová
Jarmila
J
Synytsya
Alla
A
Poucková
Pavla
P
Sessler
Jonathan L
JL
D000818:Animals; D005260:Female; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010190:Pancreatic Neoplasms / Q000378:metabolism; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D014018:Tissue Distribution; D014183:Transplantation, Heterologous
D011166:Porphyrins; C440448:sapphyrin