title: [Evolution of susceptibility of aerobic gram-negative aerobic bacilli to quinolones and fluoroquinolones in a university hospital (1992-2000)].
abstract: Susceptibility to quinolones of aerobic gram-negative bacilli was assessed in a 2000-bed university hospital from 1992 to 2000. There was a significant downward trend in the rate of susceptibility to nalidixic acid (Nal) for Enterobacteriaceae as a whole from 1992 to 2000 (86% vs 82%), and E. coli (92% vs 84%), and an upward trend for K. pneumoniae (74% vs 82%), the latter being related to the control of the spread of epidemic ESBL producing strains. The overall susceptibility of Enterobacteriaceae to ciprofloxacin (Cip) paralleled the susceptibility to Nal: decreased susceptibility for Enterobacteriaceae as a whole (96% vs 89%) and E. coli (99% vs 91%). A clear decrease in the level of susceptibility to Cip occurred during the study period among the Nal-resistant strains as demonstrated by the decrease in the median zone diameter (D) observed among the Nal-resistant strains of E. coli (26 mm in 1992 vs 19 mm in 1998-2000). The zone diameter distribution pattern changed from an unimodal distribution in 1992 to a trimodal distribution in 2000 secondary to the occurrence of a population of resistant strains (D = 13 mm) and of a highly resistant population (D = 6 mm). Finally, the susceptibility to Cip of P. aeruginosa strains remained stable around 62% throughout the study period.
authors.affiliation: Laboratoire de bactériologie-hygiène, hôpital Pitié-Salpêtrière, 91, boulevard de l'Hôpital, 75634 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Trystram
authors.forename: K
authors.initials: K
authors.lastname: Grenet
authors.forename: E
authors.initials: E
authors.lastname: Cambau
authors.forename: Y
authors.initials: Y
authors.lastname: Péan
authors.forename: M H
authors.initials: MH
authors.lastname: Fiévet
authors.forename: V
authors.initials: V
authors.lastname: Jarlier
authors.forename: J
authors.initials: J
authors.lastname: Robert
mesh_terms: D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D024841:Fluoroquinolones; D005602:France; D006746:Hospital Bed Capacity, 500 and over; D006785:Hospitals, University; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones