title: Association of expression of CD44v6 with systemic anaplastic large cell lymphoma: comparison with primary cutaneous anaplastic large cell lymphoma.
abstract: CD44 is a ubiquitous multifunctional cell surface adhesion molecule family. High expression of the standard form, CD44s (CD44), and its variant form, CD44v6, has been reported to be associated with tumor dissemination in non-Hodgkin lymphoma. To evaluate the potential role of CD44 and/or CD44v6 in different entities of anaplastic large cell lymphoma (ALCL), 30 cases of systemic ALCL (sALCL; 20 cases) and primary cutaneous ALCL (cALCL; 10 cases) were compared for expression of CD44 and CD44v6 by immunohistochemical staining. Expression of CD44v6 also was analyzed with respect to expression of anaplastic lymphoma kinase (ALK) in sALCL. No difference of CD44 expression was noted between sALCL and cALCL In contrast, expression of CD44v6 was found in 18 (90%) of sALCL cases and in 5 (50%) of cALCL cases. There was no correlation between expression of CD44v6 and expression of ALK in sALCL. These results indicate that expression of CD44v6 rather than CD44 correlates with sALCL. Furthermore, these results suggest that CD44v6 and ALK may be independent predictors of risk for the systemic phenotype of ALCL.
authors.affiliation: Department of Pathology, University of Colorado School of Medicine, Denver, USA.
authors.forename: Xiayuan
authors.initials: X
authors.lastname: Liang
authors.forename: Loren E
authors.initials: LE
authors.lastname: Golitz
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Smoller
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Meech
authors.forename: Lorrie F
authors.initials: LF
authors.lastname: Odom
authors.forename: Sara A
authors.initials: SA
authors.lastname: Williams
authors.forename: John W
authors.initials: JW
authors.lastname: Ryder
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000708:Anaplasia / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D000077548:Anaplastic Lymphoma Kinase; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D006023:Glycoproteins / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis / Q000096:biosynthesis*; D007150:Immunohistochemistry; D016130:Immunophenotyping; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011505:Protein-Tyrosine Kinases / Q000032:analysis / Q000096:biosynthesis; D020794:Receptor Protein-Tyrosine Kinases; D012189:Retrospective Studies; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
chemical_list: C112697:CD44v6 antigen; D006023:Glycoproteins; D018960:Hyaluronan Receptors; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases