Haptoglobin and malaria.
Haptoglobin gene knockout mice and wild-type controls were infected with Plasmodium berghei ANKA or Plasmodium chabaudi. The peak parasitaemia and parasite burden were higher in Hp-/- mice than in Hp+/+ mice. The increase in spleen weight following malaria infection was smaller in Hp-/- mice than in Hp+/+ animals. The occurrence of cerebral malaria in P. berghei ANKA infection was not different in Hp gene knockout mice and their controls.
Hunt
N H
NH
Department of Pathology, University of Sydney, New South Wales, Australia. nhunt@med.usyd.edu.au
Driussi
C
C
Sai-Kiang
L
L
D000818:Animals; D005260:Female; D006242:Haptoglobins / Q000378:metabolism* / Q000502:physiology*; D008288:Malaria / Q000378:metabolism* / Q000469:parasitology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D018345:Mice, Knockout; D009929:Organ Size; D010962:Plasmodium berghei / Q000378:metabolism; D012737:Sex Factors; D013154:Spleen / Q000469:parasitology
D006242:Haptoglobins