Functional peculiarities of MAP2 in DBA/2J inbred mice as a component of genetic predisposition to seizures.
We compared the content of high molecular microtubule-associated protein-2 and its phosphorylation by cAMP- and Ca(2+)/calmodulin-dependent protein kinases in the brain of DBA/2J and C57Bl/6 inbred mice. The revealed differences in protein content and phosphorylation can be attributed to the mechanisms mediating audiogenic seizures in DBA/2J mice and to differential sensitivity of these inbred lines to seizure-inducing factors.
Chulanova
T A
TA
Group of the Mechanisms of Synaptic Transmission, Institute of Theoretical and Experimental Biophysics, Pushchino. neurochem@mail.ru
Echikov
S N
SN
Sadovnikov
V B
VB
Shchipakina
T G
TG
D000818:Animals; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000201:enzymology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006624:Hippocampus / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D010766:Phosphorylation; D012640:Seizures / Q000235:genetics*; D013696:Temperature; D013997:Time Factors
D008869:Microtubule-Associated Proteins; D017868:Cyclic AMP-Dependent Protein Kinases