Synthesis of 1,4-disubstituted 2-methylpiperazine derivatives, new 5-HT(1A) receptor ligands.
Preparation of some new 1,4-substituted 2-methylpiperazine derivatives is reported. The influence of structural modifications on their affinity to 5-HT(1A) receptors is discussed. Compounds were synthesised by the reaction of 2-methylpiperazine with 2-chloropyrimidine or 2-chloroquinoline followed by condensation with 1,4 dibromobutane. The resulting quaternary ammonium salts after the reaction with an imide gave the respective final products.
Cybulski
M
M
Pharmaceutical Research Institute, Warsaw, Poland.
Dankiewicz
W
W
Chilmończyk
Z
Z
D000818:Animals; D001667:Binding, Competitive; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism; D066298:In Vitro Techniques; D008024:Ligands; D010879:Piperazines / Q000138:chemical synthesis* / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism*; D044263:Receptors, Serotonin, 5-HT1; D018490:Serotonin Agents / Q000138:chemical synthesis* / Q000378:metabolism
D008024:Ligands; D010879:Piperazines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D018490:Serotonin Agents