[Myocardial and vascular impairment in diabetes mellitus].
OBJECTIVE
To study relations between ischemic heart disease (IHD) and hormonal and metabolic disorders in patients with diabetes mellitus and IHD.


METHODS
Cuff test was used to study functional activity of the vessels. Platelet aggregation, prostacyclin, antithrombin III were studied in 168 healthy subjects, diabetes mellitus (DM) patients (n = 98) and DM type 2 patients (n = 118).


RESULTS
Microscopic examinations of the myocardium (endomyocardial biopsy) were made and the results were compared to antithrombogenic activity of vascular wall in DM. Myocardial vessels in the patients have undergone morphological alterations. Antithrombogenic activity of the vessels in DM patients was studied under compression.


CONCLUSIONS
Microcirculation was found changed: vascular walls were thick and homogenized, endothelyocytes underwent edema and destruction with enlargement of the basal membrane. Platelet hypersensitivity was proved in DM as well as more active metabolism of arachidonic acid, low prostacyclin endothelial activity.
Sokolov
E I
EI
D000328:Adult; D016718:Arachidonic Acid / Q000378:metabolism; D001160:Arterioles / Q000648:ultrastructure; D001161:Arteriosclerosis / Q000209:etiology / Q000473:pathology; D002196:Capillaries / Q000648:ultrastructure; D003331:Coronary Vessels / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000473:pathology*; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000209:etiology / Q000473:pathology*; D009206:Myocardium / Q000648:ultrastructure*; D010974:Platelet Aggregation; D014699:Venules / Q000648:ultrastructure
D016718:Arachidonic Acid