title: Stabilization of pharmaceuticals to oxidative degradation.
abstract: A guide for stabilization of pharmaceuticals to oxidation is presented. Literature is presented with an attempt to be a ready source for data and recommendations for formulators. Liquid and solid dosage forms are discussed with options including formulation changes, additives, and packaging documented. In particular, selection of and methods for use of antioxidants are discussed including recommended levels.
authors.affiliation: Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. ken_waterman@groton.pfizer.com
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Waterman
authors.forename: Roger C
authors.initials: RC
authors.lastname: Adami
authors.forename: Karen M
authors.initials: KM
authors.lastname: Alsante
authors.forename: Jinyang
authors.initials: J
authors.lastname: Hong
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Landis
authors.forename: Franco
authors.initials: F
authors.lastname: Lombardo
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Roberts
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D002384:Catalysis; D002626:Chemistry, Pharmaceutical; D004247:DNA / Q000737:chemistry; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D011506:Proteins / Q000737:chemistry; D012995:Solubility; D013242:Sterilization
chemical_list: D000975:Antioxidants; D011506:Proteins; D004247:DNA