title: Physostigmine does not antagonize sevoflurane anesthesia assessed by bispectral index or enhances recovery.
abstract: In this double-blinded study, we investigated the effect of physostigmine on sevoflurane anesthesia and recovery. Forty female patients scheduled for breast biopsy were randomly assigned to receive either physostigmine 2 mg IV or an equal volume of normal saline after skin closure. Anesthesia was induced and maintained with sevoflurane in oxygen. After skin closure, a steady state of 0.6% inspired and end-tidal sevoflurane concentration was obtained, heart rate, blood pressure, and Bispectral index (BIS) baseline values were recorded, and physostigmine or normal saline was administered. Hemodynamics and BIS values were also recorded 5, 8, and 10 min after treatments. Anesthesia was discontinued, and orientation, sedation, sitting ability, and "picking up matches" scores were recorded immediately after extubation and 15 and 30 min later. No differences were found between the two groups in BIS (69, 70, 70, and 71 in the Physostigmine group versus 70, 74, 75, and 76 in the Control group) or blood pressure. Only heart rate was increased 8 min after physostigmine (P < 0.05 versus the control). Scores assessing early recovery were similar in the two groups at all time points. We conclude that physostigmine does not change BIS or enhance recovery after sevoflurane anesthesia.
  
  
  CONCLUSIONS
  This double-blinded, randomized study investigated the impact of physostigmine of BIS values during 0.6% sevoflurane anesthesia as well as in the postoperative recovery, when sevoflurane is administered as a sole anesthetic. Physostigmine has no effect on BIS values or on the tests assessing recovery.
authors.affiliation: Department of Anesthesiology, St Savas Hospital, Athens, Greece.
authors.forename: Adia
authors.initials: A
authors.lastname: Paraskeva
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Papilas
authors.forename: Argyro
authors.initials: A
authors.lastname: Fassoulaki
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Melemeni
authors.forename: Georgios
authors.initials: G
authors.lastname: Papadopoulos
mesh_terms: D000328:Adult; D000758:Anesthesia; D018685:Anesthetics, Inhalation / Q000037:antagonists & inhibitors*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D006801:Humans; D008738:Methyl Ethers / Q000037:antagonists & inhibitors*; D010830:Physostigmine / Q000494:pharmacology*; D011446:Prospective Studies; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D002800:Cholinesterase Inhibitors; D008738:Methyl Ethers; D000077149:Sevoflurane; D010830:Physostigmine