title: Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation.
abstract: B cells possess a variety of immune functions that are involved in normal and abnormal immune responses, including autoimmune disorders. Through murine models of intestinal inflammation, we here demonstrate a B cell subset that is induced in gut-associated lymphoid tissues and is characterized by CD1d upregulation. This B cell subset appears under a chronic inflammatory environment, produces IL-10, and suppresses progression of intestinal inflammation by downregulating inflammatory cascades associated with IL-1 upregulation and STAT3 activation rather than by altering polarized T helper responses. This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions.
authors.affiliation: Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA. amizoguchi@partners.org
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizoguchi
authors.forename: Emiko
authors.initials: E
authors.lastname: Mizoguchi
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takedatsu
authors.forename: Richard S
authors.initials: RS
authors.lastname: Blumberg
authors.forename: Atul K
authors.initials: AK
authors.lastname: Bhan
mesh_terms: D000818:Animals; D018949:Antigens, CD1 / Q000235:genetics / Q000276:immunology*; D055610:Antigens, CD1d; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D002908:Chronic Disease; D003092:Colitis / Q000276:immunology* / Q000473:pathology; D003106:Colon / Q000276:immunology* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics; D008221:Lymphoid Tissue / Q000166:cytology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D015854:Up-Regulation / Q000276:immunology*
chemical_list: D018949:Antigens, CD1; D055610:Antigens, CD1d; D016753:Interleukin-10