[Lemofloxacin: antimicrobial ability and clinico-pharmacokinetic basis for use in urogenital infections].
Lomefloxacin, as other fluoroquinolones, is a drug of choice in the treatment of uncomplicated urinary infections (acute cystitis, pyclonephritis) in outpatient practice. The advantage of lomefloxacin consists in a single-dose regimen (400 mg with 24-h interval). A course of acute cystitis lasts 3 days, acute pyelonephritis--10-14 days. Lomefloxacin is also the first-line drug in exacerbation of mild or moderate chronic pyclonephritis in hospitals and outpatient clinics. Fluoroquinolones are now most effective in management of acute or exacerbation of chronic bacterial prostatitis. Optimal lomefloxacin regimen in prostatitis is 400 mg with 24-h interval for one month. For prevention of postoperative suppuration in prostatic resection lomefloxacin is given in a single dose 400 mg 3-6 hours prior to operation. If operation is to be performed in the presence of urinary infection or prostatitis, lomefloxacin should be taken for 5-7 days before surgery.
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D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D052776:Female Urogenital Diseases / Q000188:drug therapy* / Q000382:microbiology; D024841:Fluoroquinolones; D006801:Humans; D052801:Male Urogenital Diseases; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin