title: [Cell culture models of transmissible spongiform encephalopathies].
abstract: Cell cultures represent versatile and useful experimental models of transmissible spongiform encephalopathies. These models include chronically prion infected cell lines, as well as cultures expressing variable amounts of wild-type, mutated or chimeric prion proteins. These cultures have been widely used to investigate the biology of both the normal and the pathological isoform of the prion protein. They have also contributed to the comprehension of the pathogenic processes occurring in transmissible spongiform encephalopathies and in the development of new therapeutic approaches of these diseases.
authors.affiliation: Institut de génétique humaine, CNRS UPR 1142, 141, rue de la Cardonille, 34396 Montpellier, France. Sylvain.Lehmann@igh.cnrs.fr
authors.forename: Sylvain
authors.initials: S
authors.lastname: Lehmann
authors.forename: Florence
authors.initials: F
authors.lastname: Béranger
authors.forename: Jérôme
authors.initials: J
authors.lastname: Solassol
authors.forename: Audrey
authors.initials: A
authors.lastname: Ceschia
authors.forename: Véronique
authors.initials: V
authors.lastname: Perrier
authors.forename: Aude
authors.initials: A
authors.lastname: De Gassart
authors.forename: Didier
authors.initials: D
authors.lastname: Vilette
authors.forename: Hubert
authors.initials: H
authors.lastname: Laude
authors.forename: Odile
authors.initials: O
authors.lastname: Kellermann
authors.forename: Alain
authors.initials: A
authors.lastname: Mangé
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D002460:Cell Line; D015870:Gene Expression; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009154:Mutation; D017096:Prion Diseases; D011328:Prions / Q000235:genetics; D014162:Transfection
chemical_list: D011328:Prions