Wiring the zebrafish: axon guidance and synaptogenesis.
Many zebrafish mutants have specific defects in axon guidance or synaptogenesis, particularly in the retinotectal and motor systems. Several mutants have now been characterized in detail and/or cloned. A combination of genetic studies, in vivo imaging and new techniques for misexpressing genes or blocking their function promises to reveal the molecules and principles that govern wiring of the vertebrate nervous system.
Hutson
Lara D
LD
Department of Neurobiology and Anatomy, Room 401 Medical Research and Engineering Building, 20 North 1900 East, University of Utah Medical Center, Salt Lake City, Utah 84132, USA.
Chien
Chi-Bin
CB
D000818:Animals; D001369:Axons / Q000502:physiology*; D009420:Nervous System / Q000166:cytology* / Q000196:embryology*; D009434:Neural Pathways / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D015027:Zebrafish / Q000196:embryology*