Engineered modeling and the secrets of Parkinson's disease.
The development of new methods for manipulating the animal genome by transgenic and gene-targeting technologies provides a unique means of studying the most intimate aspects of countless human diseases, including Parkinson's disease (PD). In this review, the contribution of such engineered models to our current understanding of the pathophysiology, etiology and pathogenesis of PD will be discussed.
Vila
M
M
Dept Neurology, Columbia University, New York, NY 10032, USA.
Wu
D C
DC
Przedborski
S
S
D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D006801:Humans; D010300:Parkinson Disease / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology*