title: Cytotoxic withanolides from Acnistus arborescens.
abstract: Three cytotoxic withanolides, two with new structures, were isolated from the leaves of Acnistus arborescens and their structures determined by a combination of 1D and 2D NMR, mass spectral, and molecular modeling studies. Dereplication analysis of the ethyl ether extract was useful for evaluating the components showing significant cytotoxic activity.
authors.affiliation: Instituto de Química, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.
authors.forename: Sandro
authors.initials: S
authors.lastname: Minguzzi
authors.forename: Lauro E S
authors.initials: LE
authors.lastname: Barata
authors.forename: Young Geun
authors.initials: YG
authors.lastname: Shin
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Jonas
authors.forename: Hee Byung
authors.initials: HB
authors.lastname: Chai
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Park
authors.forename: John M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Cordell
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D004852:Epoxy Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000096:biosynthesis / Q000187:drug effects; D010840:Phytosterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019657:Solanaceae / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D007783:Lactones; D010840:Phytosterols; D016660:NAD(P)H Dehydrogenase (Quinone)