title: Safe administration of etoposide phosphate after hypersensitivity reaction to intravenous etoposide.
abstract: Etoposide is commonly used in a variety of malignancies. A well known but rare toxicity are hypersensitivity reactions, usually manifested by chest discomfort, dyspnoea, bronchospasm and hypotension. We report the details of a patient who developed hypersensitivity reactions to intravenous etoposide, but subsequently tolerated the administration of intravenous etoposide phosphate with no sequelae.
authors.affiliation: Pharmacy Department, Austin & Repatriation Medical Centre, Studley Road, Heidelberg, Australia. jim.siderov@armc.org.au
authors.forename: J
authors.initials: J
authors.lastname: Siderov
authors.forename: P
authors.initials: P
authors.lastname: Prasad
authors.forename: R
authors.initials: R
authors.lastname: De Boer
authors.forename: J
authors.initials: J
authors.lastname: Desai
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004342:Drug Hypersensitivity / Q000517:prevention & control*; D005047:Etoposide / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009943:Organophosphorus Compounds / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D009943:Organophosphorus Compounds; C061400:etoposide phosphate; D005047:Etoposide