title: Differential metabolic rates in prefrontal and temporal Brodmann areas in schizophrenia and schizotypal personality disorder.
abstract: In an exploration of the schizophrenia spectrum, we compared cortical metabolic rates in unmedicated patients with schizophrenia and schizotypal personality disorder (SPD) with findings in age- and sex-matched normal volunteers. Coregistered magnetic resonance imaging (MRI) and positron emission tomography (PET) scans were obtained in 27 schizophrenic, 13 SPD, and 32 normal volunteers who performed a serial verbal learning test during tracer uptake. A template of Brodmann areas derived from a whole brain histological section atlas was used to analyze PET findings. Significantly lower metabolic rates were found in prefrontal areas 44-46 in schizophrenic patients than in normal volunteers. SPD patients did not differ from normal volunteers in most lateral frontal regions, but they had values intermediate between those of normal volunteers and schizophrenic patients in lateral temporal regions. SPD patients showed higher than normal metabolic rates in both medial frontal and medial temporal areas. Metabolic rates in Brodmann area 10 were distinctly higher in SPD patients than in either normal volunteers or schizophrenic patients.
authors.affiliation: Neuroscience PET Laboratory, Department of Psychiatry, Mt. Sinai School of Medicine, Box 1505, One Gustave L. Levy Place, New York, NY 10029-6574, USA. monte.buchsbaum@mssm.edu
authors.forename: Monte S
authors.initials: MS
authors.lastname: Buchsbaum
authors.forename: Igor
authors.initials: I
authors.lastname: Nenadic
authors.forename: Erin A
authors.initials: EA
authors.lastname: Hazlett
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Spiegel-Cohen
authors.forename: Michael B
authors.initials: MB
authors.lastname: Fleischman
authors.forename: Arash
authors.initials: A
authors.lastname: Akhavan
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Silverman
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Siever
mesh_terms: D000328:Adult; D001303:Auditory Cortex / Q000002:abnormalities / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000002:abnormalities / Q000378:metabolism* / Q000503:physiopathology*; D012559:Schizophrenia / Q000378:metabolism* / Q000503:physiopathology*; D012569:Schizotypal Personality Disorder / Q000378:metabolism* / Q000503:physiopathology*; D013702:Temporal Lobe / Q000002:abnormalities / Q000378:metabolism* / Q000503:physiopathology*; D014055:Tomography, Emission-Computed; D014793:Visual Cortex / Q000002:abnormalities / Q000378:metabolism / Q000503:physiopathology