title: Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs.
abstract: Chemotherapy and chemoprophylaxis are the principal means of combating malaria parasite infections in the human host. In the last 75 years, since the introduction of synthetic antimalarials, only a small number of compounds have been found suitable for clinical usage, and this limited armoury is now greatly compromised by the spread of drug-resistant parasite strains. Our current knowledge of the molecular mechanisms underlying resistance in the lethal species Plasmodium falciparum is reviewed here.
authors.affiliation: Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, P.O. Box 88, M60 1QD, Manchester, UK. john.hyde@umist.ac.uk
authors.forename: John E
authors.initials: JE
authors.lastname: Hyde
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004351:Drug Resistance; D005493:Folic Acid Antagonists / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D017125:Genes, Protozoan / Q000235:genetics; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity
chemical_list: D000962:Antimalarials; D005493:Folic Acid Antagonists