Endothelin-mediated preeclampsia at high altitude.
Preeclampsia is pregnancy-induced hypertension. The hypoxia at high altitude increases the incidence of preeclampsia. Endothelin is released in response to hypoxia and is associated with other hypertensive states at high altitude. Endothelin may play a major role in preeclampsia for individuals residing at high altitude. Endothelin antagonists may prove useful in the treatment of preeclampsia.
Angerio
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School of Nursing, Department of Physiology and Biophysics, Georgetown University, Washington, DC, USA.
D000531:Altitude; D015984:Causality; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood* / Q000453:epidemiology* / Q000628:therapy; D011247:Pregnancy
D016232:Endothelins