Constituents of the leaves and twigs of Ficus hispida.
A new norisoprenoid, ficustriol (1), and the known phenanthroindolizidine alkaloid O-methyltylophorinidine (2), were isolated from a CHCl3 extract of the leaves and twigs of Ficus hispida. O-Methyltylophorinidine showed potent cytotoxic activity when tested against a small panel of human cancer cells, while ficustriol was inactive. The structure and stereochemistry of 1 were determined using chemical and spectral methods.
Peraza-Sánchez
Sergio R
SR
Chai
Hee-Byung
HB
Shin
Young Geun
YG
Santisuk
Thawatchai
T
Reutrakul
Vichai
V
Farnsworth
Norman R
NR
Cordell
Geoffrey A
GA
Pezzuto
John M
JM
Kinghorn
A Douglas
AD
D030681:Ficus; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013785:Thailand; D014407:Tumor Cells, Cultured / Q000187:drug effects
D026121:Indole Alkaloids; C455126:O-methyltylophorinidine; D010616:Phenanthrenes; D010936:Plant Extracts; D013729:Terpenes; C455127:ficustriol