100 years of peroxynitrite chemistry and 11 years of peroxynitrite biochemistry.
The paper on the unusual properties of a mixture of hydrogen peroxide and nitrous acid by Baeyer and Villiger from 1901 can be regarded as the first report on peroxynitrite. In 1990, Beckman and co-workers suggested that peroxynitrite, formed from the reaction of superoxide with nitrogen monoxide, could be a transient oxidizing species in vivo, a report that revolutionized investigations in the field of oxidative stress.
Koppenol
W H
WH
Laboratorium für Anorganische Chemie, Eidgenössische Technische Hochschule, Zürich, Switzerland. koppenol@inorg.chem.ethz.ch
D001671:Biochemistry / Q000266:history*; D002621:Chemistry / Q000266:history*; D049673:History, 20th Century; D030421:Peroxynitrous Acid / Q000266:history*
D030421:Peroxynitrous Acid