Effect of repeated administration of the antioxidant stobadine on the behavior of singly-housed male mice in intraspecies conflict.
The aim of the present study was to assess the effect of repeated oral administration of stobadine (70 mg/kg) on the occurrence of selected behavioral elements during exposure to an intraspecies conflict between singly-housed and group-housed male mice. Isolation induced timidity (defensive-escape behavior without attacks) in most mice (87%). This isolation-induced timidity was reduced after stobadine treatment. In the stobadine-treated group, sociable activities (following, climbing) were also decreased. After discontinuation of the treatment (18 days), aggressive behavior tended to increase in the stobadine-treated group. The results of this study are indicative of an inhibitory effect of repeated administration of stobadine on some behavioral activities of singly-housed male mice in an intraspecies conflict.
Dubovický
M
M
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovakia.
Ujházy
E
E
Kovacovský
P
P
Mach
M
M
D000374:Aggression / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002243:Carbolines / Q000494:pharmacology*; D003220:Conflict, Psychological; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D012934:Social Isolation / Q000523:psychology*
D000975:Antioxidants; D002243:Carbolines; C100106:dicarbine