[Photoinactivation of microorganisms in the presence of photosensitizers].
Two photosensitizing preparation for the photodynamic therapy of oncological diseases have been obtained. As revealed in this study, under experimental conditions their action suppresses the growth of Enterococcus faecalis and Staphylococcus aureus, which may be of great importance for the treatment of infections. And in contrast to antibiotic therapy, their use may not affect the development of normal intestinal microflora. The study has shown that their derivatives with the residues of carbonic (or muramic) acids more intensively penetrate microorganisms through their cell walls. This makes in possible to expand the spectrum of action of the preparations. The proposed method permits the rapid analysis of the photochemical activity of preparation for photodynamic therapy in the process of their development.
Romanov
V P
VP
State Research Center Vector-Research Design and Teshnological Institute of Biologically Active Substances, Berdsk, Novosibirsk Region, Russia.
Lebedev
L R
LR
Tereshchenko
T A
TA
Nazarikova
N I
NI
Masycheva
V I
VI
D001431:Bacteriological Techniques; D001681:Biological Assay; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000254:growth & development; D006415:Hematoporphyrins / Q000737:chemistry / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D054833:Isoindoles; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development
D006415:Hematoporphyrins; D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; C013647:phthalocyanine