Photoreceptor cells in flies and mammals: Crumby homology?
Recently, two papers have revealed a new function for the fruit fly epithelial apical membrane protein Crumbs and its mammalian homolog CRB1 in photoreceptor cell morphogenesis. This supports the previous observation that disruption of CRB1 function can cause retinal degeneration in humans.
Kowalczyk
Andrew P
AP
Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Moses
Kevin
K
D000818:Animals; D004175:Diptera; D029721:Drosophila Proteins / Q000502:physiology*; D005136:Eye Proteins; D006801:Humans; D008322:Mammals; D008565:Membrane Proteins / Q000502:physiology*; D009419:Nerve Tissue Proteins; D017956:Photoreceptor Cells, Invertebrate / Q000502:physiology*; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology*
C448939:CRB1 protein, human; D029721:Drosophila Proteins; D005136:Eye Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C064360:crb protein, Drosophila