[Preliminary study on relationship between antibody against heat stress protein 70 and hypertension].
OBJECTIVE
To preliminarily explore the relationship between main antibody against heat stress protein 70 (anti-HSP70) and hypertension.


METHODS
Serum anti-HSP70 was determined with Western blotting technique in hypertensive and normotensive groups. Logistic regression model was used to analyze the relationship between anti-HSP70 and hypertension.


RESULTS
It was found that level of antibody against the main heat shock protein 70 was significantly higher in patients with hypertension (based on criteria of 160/95 mm Hg, 1 mm Hg = 0.133 kPa) than in controls, after adjustment for the generally recognized risk factors for hypertension (such as age, sex, length of employment, body mass index, job, et al.). There still was stronger association between anti-HSP70 and hypertension (based on criteria of 140/90 mm Hg), but its strength of association was weaker than the former.


CONCLUSIONS
Anti-HSP70 may potentially serve as a serum biomarker to assess hypertension, or anti-HSP70 itself may be involved in the development of hypertension.
Ma
J
J
Department of Epidemiology, Anhui Medical Univisity, Hefei, 230032, China.
Sun
Y
Y
Cao
D
D
Chen
S
S
Xiao
C
C
Wu
J
J
Wu
T
T
D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D006973:Hypertension / Q000276:immunology*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D012333:RNA, Messenger / Q000378:metabolism; D012494:Sampling Studies
D001323:Autoantibodies; D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins; D012333:RNA, Messenger