[A clinical investigation on the relationship between nitric oxide and elevation of intraocular pressure in glaucoma].
OBJECTIVE
To investigate the role of nitric oxide (NO) in the process of intraocular pressure (IOP) elevation in glaucoma.


METHODS
The levels of NO in plasma and in aqueous humor which were obtained from 16 patients with acute angle closure glaucoma (10 female, 6 male), 29 cases with cataract (13 female, 16 male) and 30 normal volunteers (13 female, 17 male) were detected by high performance liquid chromatography and expressed with the total NO(2) and NO(3).


RESULTS
It was found that the mean level of NO in the plasma in glaucoma group was (l,390.78 +/- 302.95) ng/L that was significantly lower than that in the normal group (2 969.37 +/- 862.85) ng/L (t = 2.853, P < 0.01). But in cataract group it was (4,234.89 +/- 1,495.23) ng/L that was significantly higher than that in the normal group (t = 4.471, P < 0.01). There was no significant difference in the level of NO in the aqueous humor between glaucoma group (2,052.03 +/- 694.74) ng/L and normal group (1,405.83 +/- 602.70) ng/L (t = l.862, P > 0.05). But in cataract group the mean level of NO (2, 454.67 +/- 655.13) ng/L in the aqueous humor was increased remarkably in comparison with that in the normal group (t = 2.752, P < 0.01). The rate of the mean content of NO in normal aqueous humor and plasma (aqueous/plasma) was 47.3%, and that in cataract group, 57.96% (P > 0.05). But in glaucoma group, the rate was 144.0%.


CONCLUSIONS
The content of nitric oxide in the plasma and aqueous humor is related to the elevation of IOP in cases with acute angle closure glaucoma.
Han
Y
Y
Department of Ophthalmology, Affiliated Second Hospital, Hebei Medical University, Shijiazhuang 050000, China.
Zhang
B
B
Guo
X
X
Zhang
Z
Z
D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis*
D009569:Nitric Oxide