title: Pulmonary colonization by Chrysosporium zonatum associated with allergic inflammation in an immunocompetent subject.
abstract: We report a case of noninvasive pulmonary disease due to Chrysosporium zonatum in an immunocompetent male. The fungus colonized an existing tuberculous cavity and was isolated from transbronchial lavage fluid and from a percutaneous aspiration specimen. The disease was accompanied by the unusual feature of an allergic reaction. The fungus ball was successfully treated by intracavitary administration of amphotericin B. C. zonatum is the anamorph of the heterothallic ascomycete Uncinocarpus orissi, and the identity of the case isolate was verified by formation of ascospores in mating tests with reference isolates.
authors.affiliation: Division of Pulmonary Diseases, Department of Internal Medicine, Microbiology Branch, Saga Medical School, Saga, Japan. hayashs@post.saga-med.ac.jp
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Hayashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Naitoh
authors.forename: Shinichi
authors.initials: S
authors.lastname: Matsubara
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nakahara
authors.forename: Zenzo
authors.initials: Z
authors.lastname: Nagasawa
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tanabe
authors.forename: Kohzi
authors.initials: K
authors.lastname: Kusaba
authors.forename: Jutaro
authors.initials: J
authors.lastname: Tadano
authors.forename: Kazuko
authors.initials: K
authors.lastname: Nishimura
authors.forename: Lynne
authors.initials: L
authors.lastname: Sigler
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000494:pharmacology; D002912:Chrysosporium / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D006967:Hypersensitivity / Q000382:microbiology*; D007249:Inflammation / Q000382:microbiology*; D008168:Lung / Q000382:microbiology*; D008172:Lung Diseases, Fungal / Q000382:microbiology*; D008297:Male; D008826:Microbial Sensitivity Tests
chemical_list: D000666:Amphotericin B