title: [Epidemiological observation on effect of Leptospiral outer membrane vaccine].
abstract: OBJECTIVE
  To study the safety and effect of Leptospiral outer membrane vaccine.
  
  
  METHODS
  Eighty thousands dosages of Leptospiral outer membrane vaccine were vaccinated in Jingzhou and Shishou city Hubei prevince. Temperaure, side-effects such as Local edema with in 48 hours as well as the incidence of Leptospirsis within a year among those were vaccinated and unvaccinated were observed.
  
  
  RESULTS
  (1) No any severe side-effect and abnormal reaction, was found, only 2 case suffered from slight fever and local edema which receded in 48 hrs. (2) Effects of Leptospiral outer membrane vaccine were as follows: 2 cases were attacked by lacterohaemorrhagiae in vaccination group and 47 cases in control group, so the protection rate 95.57% and confidence interval (CI) was 85.43% - 98.20%. Fifteen hebdomadis cases were found in control group. The protection rate of this vaccine reached 100.00%, CI 77.08% - 100.00%.
  
  
  CONCLUSIONS
  Safty and protective effect were well showed when type of bacteria was concordant with that in vaccination district.
authors.affiliation: Hubei Provincial Anti-Epidemics and Sanitation Center, Wuhan 430079, China.
authors.forename: J
authors.initials: J
authors.lastname: Cheng
authors.forename: J
authors.initials: J
authors.lastname: Qin
authors.forename: G
authors.initials: G
authors.lastname: Xie
mesh_terms: D000293:Adolescent; D000328:Adult; D001428:Bacterial Vaccines / Q000009:adverse effects / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007919:Leptospira / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014611:Vaccination
chemical_list: D001428:Bacterial Vaccines