[Effect of blocking angiotensin receptors on cerebral blood flow in the post-ischemic period in hypertensive rats].
Acute experiments on anesthetized rats have been conducted to study the effect of lozartan (5 mg/kg i.p.) on cerebral circulation and its autoregulation in hypertensive animals (a vasorenal model) in postischemic period. Transitory ischemia was induced by bilateral compression of the carotid arteries for 12 minutes, continued--by ligation of the carotid arteries. It was found that blockade of angiotensin receptors by lazartan provoked lowering of systemic arterial pressure. Changes in cerebral circulation were unstable, depended on arterial pressure and vascular cerebral resistance. The lower limit of autoregulation of the brain flow shifted to higher arterial pressure in hypertensive animals before brain ischemia and disorder after ischemia. Lozartan promoted recovery of the autoregulatory reactions of the brain vessels and raised survival of rats in continuous ligation of the carotid arteries.
Adzhienko
L M
LM
D057911:Angiotensin Receptor Antagonists; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000503:physiopathology*; D006973:Hypertension / Q000503:physiopathology*; D019808:Losartan / Q000494:pharmacology*; D051381:Rats
D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D019808:Losartan