title: Effect of pregnancy and obstructive jaundice on inflammatory diseases: the work of P S Hench revisited.
abstract: Hench considered that cortisone improved inflammatory joint symptoms during pregnancy and obstructive jaundice. However, the improved symptoms are probably due to changes in the proportions of fatty acids in plasma and inflammatory cell phospholipids. These changes decrease the superoxide anions and eicosanoids produced and also reduce tumour necrosis factor alpha production.
authors.affiliation: David Evans Medical Research Centre, Nottingham City Hospital NHS Trust, Hucknall Road, Nottingham NG5 1PB, UK.
authors.forename: I
authors.initials: I
authors.lastname: Crocker
authors.forename: N
authors.initials: N
authors.lastname: Lawson
authors.forename: J
authors.initials: J
authors.lastname: Fletcher
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D002779:Cholestasis / Q000150:complications*; D016207:Cytokines / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D011247:Pregnancy; D011248:Pregnancy Complications; D013481:Superoxides / Q000378:metabolism; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism
chemical_list: D000305:Adrenal Cortex Hormones; D016207:Cytokines; D005227:Fatty Acids; D013481:Superoxides