Maternal effects in molecular evolution.
We introduce a model of molecular evolution in which the fitness of an individual depends both on its own and on the parent's genotype. The model can be solved by means of a nonlinear mapping onto the standard quasispecies model. The dependency on the parental genotypes cancels from the mean fitness, but not from the individual sequence concentrations. For finite populations, the position of the error threshold is very sensitive to the influence from parent genotypes. In addition to biological applications, our model is important for understanding the dynamics of self-replicating computer programs.
Wilke
Claus O
CO
Digital Life Laboratory, Mail Code 136-93, Pasadena, California 91125, USA. wilke@caltech.edu
D000818:Animals; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D008957:Models, Genetic; D009035:Mothers