title: Hypothalamic histamine neurons activate lipolysis in rat adipose tissue.
abstract: The contribution of hypothalamic histamine neurons to the central regulation of peripheral lipid metabolism was investigated in rats using in vivo microdialysis system. A bolus infusion of L-histamine at doses of 10--10(3) nmol/rat into the third cerebral ventricle (i3vt) dose-dependently increased glycerol concentration in the perfusate from the epididymal adipose tissue. I3vt infusion of 10(2) nmol/rat thioperamide, an autoinhibitory H(3) receptor antagonist that activates histamine neurons to increase synthesis and release of neuronal histamine, convincingly mimicked histamine action in the augmented lipolysis. Intraperitoneal pretreatment with propranolol, a beta-adrenoceptor antagonist, abolished the thioperamide-induced lipolytic action. An electrophysiological study demonstrated that efferent sympathetic nerves innervating the epididymal fat were activated after the i3vt infusion of thioperamide. Hypothalamic histamine neurons thus regulate peripheral lipid metabolism through the accelerating lipolytic action by activation of sympathetic beta-adrenoceptor.
authors.affiliation: School of Medicine, Department of Internal Medicine I, Oita Medical University, Hasama, Oita, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Tsuda
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yoshimatsu
authors.forename: Akira
authors.initials: A
authors.lastname: Niijima
authors.forename: Seiichi
authors.initials: S
authors.lastname: Chiba
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Okeda
authors.forename: Toshiie
authors.initials: T
authors.lastname: Sakata
mesh_terms: D000273:Adipose Tissue / Q000294:innervation / Q000502:physiology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D006632:Histamine / Q000502:physiology*; D006633:Histamine Antagonists / Q000494:pharmacology; D007031:Hypothalamus / Q000502:physiology*; D008066:Lipolysis / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology; D010880:Piperidines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000502:physiology
chemical_list: D000319:Adrenergic beta-Antagonists; D006633:Histamine Antagonists; D010880:Piperidines; D011943:Receptors, Adrenergic, beta; D006632:Histamine; D011433:Propranolol; C052075:thioperamide