title: Assessment of the Binax NOW Streptococcus pneumoniae urinary antigen test in children with nasopharyngeal pneumococcal carriage.
abstract: We evaluated the Binax NOW Streptococcus pneumoniae urinary antigen assay by testing 210 healthy children aged 2--60 months living in urban slums of Quito, Ecuador. Healthy children with nasopharyngeal carriage of S. pneumoniae were significantly more likely to have positive urinary antigen test results than were children who were not carriers (30 of 138 vs. 3 of 71 children; chi2=10.8; P<.001). The rate of nasopharyngeal carriage of S. pneumoniae decreased with increasing age; the lowest rates were found in children with the worst nutritional status.
authors.affiliation: Division of Geographic Medicine and Infectious Diseases, New England Medical Center, and Center for International Health, Boston University School of Public Health, Boston, MA, USA. dhamer@lifespan.org
authors.forename: Davidson H
authors.initials: DH
authors.lastname: Hamer
authors.forename: Josefina
authors.initials: J
authors.lastname: Egas
authors.forename: Bertha
authors.initials: B
authors.lastname: Estrella
authors.forename: William B
authors.initials: WB
authors.lastname: MacLeod
authors.forename: Jeffrey K
authors.initials: JK
authors.lastname: Griffiths
authors.forename: Fernando
authors.initials: F
authors.lastname: Sempértegui
mesh_terms: D000942:Antigens, Bacterial / Q000652:urine*; D002353:Carrier State / Q000453:epidemiology / Q000382:microbiology; D002675:Child, Preschool; D005189:False Positive Reactions; D006801:Humans; D007223:Infant; D009302:Nasopharyngeal Diseases / Q000382:microbiology; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D013296:Streptococcus pneumoniae / Q000302:isolation & purification*
chemical_list: D000942:Antigens, Bacterial; D011933:Reagent Kits, Diagnostic