Stabilization of pharmaceuticals to oxidative degradation.
A guide for stabilization of pharmaceuticals to oxidation is presented. Literature is presented with an attempt to be a ready source for data and recommendations for formulators. Liquid and solid dosage forms are discussed with options including formulation changes, additives, and packaging documented. In particular, selection of and methods for use of antioxidants are discussed including recommended levels.
Waterman
Kenneth C
KC
Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. ken_waterman@groton.pfizer.com
Adami
Roger C
RC
Alsante
Karen M
KM
Hong
Jinyang
J
Landis
Margaret S
MS
Lombardo
Franco
F
Roberts
Christopher J
CJ
D000975:Antioxidants / Q000494:pharmacology; D002384:Catalysis; D002626:Chemistry, Pharmaceutical; D004247:DNA / Q000737:chemistry; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D011506:Proteins / Q000737:chemistry; D012995:Solubility; D013242:Sterilization
D000975:Antioxidants; D011506:Proteins; D004247:DNA