A genomic regulatory network for development.
Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.
Davidson
Eric H
EH
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. davidson@caltech.edu
Rast
Jonathan P
JP
Oliveri
Paola
P
Ransick
Andrew
A
Calestani
Cristina
C
Yuh
Chiou-Hwa
CH
Minokawa
Takuya
T
Amore
Gabriele
G
Hinman
Veronica
V
Arenas-Mena
Cesar
C
Otim
Ochan
O
Brown
C Titus
CT
Livi
Carolina B
CB
Lee
Pei Yun
PY
Revilla
Roger
R
Rust
Alistair G
AG
Pan
Zheng jun
Zj
Schilstra
Maria J
MJ
Clarke
Peter J C
PJ
Arnone
Maria I
MI
Rowen
Lee
L
Cameron
R Andrew
RA
McClay
David R
DR
Hood
Leroy
L
Bolouri
Hamid
H
D000818:Animals; D019070:Cell Lineage; D019295:Computational Biology; D047108:Embryonic Development; D004707:Endoderm / Q000166:cytology / Q000502:physiology*; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D005809:Genes, Regulator; D016678:Genome; D008648:Mesoderm / Q000166:cytology / Q000502:physiology*; D008954:Models, Biological; D008957:Models, Genetic; D009024:Morphogenesis; D012045:Regulatory Sequences, Nucleic Acid; D012617:Sea Urchins / Q000196:embryology* / Q000235:genetics*; D013234:Stem Cells / Q000502:physiology; D013598:Systems Theory