Antigenemia at 10 years after diethylcarbamazine treatment of asymptomatic microfilaraemic individuals: marginal conversion to infection-free state.
A group of asymptomatic microfilaraemic individuals (n = 44, 29 males, 15 females) living in a Wuchereria bancrofti endemic region of Orissa, India, was treated with a standard regimen of diethylcarbamazine (12 days, 6 mg/kg) in 1990. The incidence of microfilaraemia and antigenemia (Og4C3) was determined after a gap of 10 years in 2000. Nineteen individuals reacquired microfilariae (43.2%, 11 males, eight females), five males developed hydrocele, two females became acute filarial patients and 18 subjects (13 males, five females) were asymptomatic amicrofilaraemics. Filarial antigen was detected in 36 individuals (81.2%, 27 male, nine female) comprising microfilaraemics, amicrofilaraemics and diseased. Only eight individuals (18.2%, two males, six females) remained antigen free.
Beuria
M K
MK
Division of Immunology, Regional Medical Research Center (ICMR), Chandrasekharpur, Bhubaneswar, Orissa, India.
Bal
M S
MS
Mandal
N N
NN
Das
M K
MK
D000293:Adolescent; D000328:Adult; D000818:Animals; D000947:Antigens, Helminth / Q000097:blood*; D004049:Diethylcarbamazine / Q000627:therapeutic use*; D005260:Female; D005368:Filariasis / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D005369:Filaricides / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007194:India; D008297:Male; D008842:Microfilariae / Q000302:isolation & purification; D008875:Middle Aged; D010361:Patients; D014958:Wuchereria bancrofti / Q000276:immunology
D000947:Antigens, Helminth; D005369:Filaricides; D004049:Diethylcarbamazine