Antigen presentation and T cell stimulation by dendritic cells.
Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides, and load these peptides onto major histocompatibility complex (MHC) class I and II molecules. Dendritic cells then migrate to secondary lymphoid organs and become competent to present antigens to T lymphocytes, thus initiating antigen-specific immune responses, or immunological tolerance. Antigen presentation in dendritic cells is finely regulated: antigen uptake, intracellular transport and degradation, and the traffic of MHC molecules are different in dendritic cells as compared to other antigen-presenting cells. These specializations account for dendritic cells' unique role in the initiation of immune responses and the induction of tolerance.
Guermonprez
Pierre
P
Institut Curie, INSERM U520, 12 rue Lhomond, 75005 Paris, France. Pierre.Guermonprez@curie.fr
Valladeau
Jenny
J
Zitvogel
Laurence
L
Théry
Clotilde
C
Amigorena
Sebastian
S
D000818:Animals; D017951:Antigen Presentation; D018949:Antigens, CD1 / Q000378:metabolism; D002454:Cell Differentiation; D002986:Clinical Trials as Topic; D003429:Cross Reactions; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D004705:Endocytosis; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D008213:Lymphocyte Activation; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D010587:Phagocytosis; D010873:Pinocytosis; D011956:Receptors, Cell Surface / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
D018949:Antigens, CD1; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D011956:Receptors, Cell Surface