title: In vitro activity of 11 antimicrobial agents, including gatifloxacin and GAR936, tested against clinical isolates of Mycobacterium marinum.
abstract: In vitro activities of 11 antimicrobial agents were determined using Etest (AB BIODISK, Solna, Sweden) against 37 clinical isolates of Mycobacterium marinum. The most potent agent (MIC(50,) 0.047 microg/mL) was trimethoprim/sulfamethoxazole, but only 91.9% would be categorized as susceptible. Several agents had a complete spectrum of activity including gatifloxacin (MIC(90,) 0.38 microg/mL), minocycline (MIC(90,) 2 microg/mL), tetracycline (MIC(90,) 2 microg/mL) and amikacin (MIC(90,) 3 microg/mL). The new glycylcycline, GAR936, had a similar potency (MIC(90,) 3 microg/mL) to that of the parent minocycline compound (MIC(90,) 2 microg/mL), but the range of MIC values extended to 24 microg/mL. Numerous options appear to exist for the contemporary therapy of M. marinum infections including some newer fluoroquinolones and derivatives of tetracycline (doxycycline, minocycline, GAR936).
authors.affiliation: The JONES Group/JMI Laboratories, North Liberty, Iowa, USA.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Rhomberg
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D000077734:Gatifloxacin; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology*; D019910:Mycobacterium marinum / Q000187:drug effects*; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D000078304:Tigecycline; D008911:Minocycline; D000077734:Gatifloxacin