title: Indications for penetrating keratoplasty and associated procedures, 1996-2000.
abstract: OBJECTIVE
  To identify current indications and trends in indications for penetrating keratoplasty and associated procedures.
  
  
  METHODS
  Retrospective chart review of all patients who underwent penetrating keratoplasty at Wills Eye Hospital from January 1, 1996 to December 31, 2000.
  
  
  RESULTS
  A total of 1,529 corneal transplants were performed during this 5-year period. The leading indications for penetrating keratoplasty were pseudophakic bullous keratopathy (PBK) in 416 (27.2%) cases, followed by regraft in 276 (18.1%), keratoconus in 236 (15.4%), and Fuchs endothelial dystrophy in 233 (15.2%) cases. Of the 416 PBK cases, 271 (65.1%) were associated with posterior chamber intraocular lenses (PC IOLs), 141 (33.9%) with anterior chamber intraocular lenses (AC IOLs), and four (1%) with iris-fixated lenses. Of these 141 AC IOLs, 107 (75.9%) were closed-loop and 34 (24.1%) were open-loop. Of the 416 PBK cases, in 281 (67.5%) cases, the IOL was not exchanged; in 127 (30.5%) cases, the IOL was exchanged; in six (1.5%) cases, the IOL was repositioned; and in two (0.5%) cases, the IOL was removed at the time of surgery. Of the 271 PC IOLs, 248 (91.5%) were not exchanged and 19 (7.1%) were exchanged. Of the 141 AC IOLs, 33 (23.4%) were not exchanged and 104 (73.7%) were exchanged (p = 0.001).
  
  
  CONCLUSIONS
  Pseudophakic bullous keratopathy remains the leading indication for corneal transplantation at our institution followed by regraft. The percentage of PBK cases associated with PC IOLs has increased significantly, whereas the percentage associated with AC IOLs has decreased. The frequency of regraft has also increased significantly.
authors.affiliation: Cornea Service, Wills Eye Hospital, Department of Ophthalmology, Jefferson Medical College, Thomas Jefferson University, 900 Walnut Street, Philadelphia, PA 19107, U.S.A.
authors.forename: C Banu
authors.initials: CB
authors.lastname: Cosar
authors.forename: M S
authors.initials: MS
authors.lastname: Sridhar
authors.forename: Elisabeth J
authors.initials: EJ
authors.lastname: Cohen
authors.forename: Evan L
authors.initials: EL
authors.lastname: Held
authors.forename: Paulo de Tarso S
authors.initials: Pde T
authors.lastname: Alvim
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Rapuano
authors.forename: Irving M
authors.initials: IM
authors.lastname: Raber
authors.forename: Peter R
authors.initials: PR
authors.lastname: Laibson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003316:Corneal Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015948:Keratoplasty, Penetrating / Q000639:trends*; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D012189:Retrospective Studies