[A preliminary study on body level of nitric oxide in workers exposed to carbon disulfide].
OBJECTIVE
To study changes in body plasma level of nitric oxide (NO) in workers exposed to carbon disulfide (CS(2)) and its possible mechanism.


METHODS
Plasma levels of NO and lipid peroxide (LPO) and activity of erythrocyte superoxide dismutase (Ery-SOD) were determined in the workers exposed and unexposed to CS(2) in a chemical synthetic fiber works.


RESULTS
Level of NO was (43.28 +/- 19.83) and (50.07 +/- 21.01) micromol/L in high- and low-dose exposed groups, respectively, significantly lower than that in the control group, which was (70.66 +/- 26.83) micromol/L (P < 0.05). Activity of Ery-SOD was 4 832.21 u/g Hb and 3,520.80 u/g Hb in high- and low-dose exposed groups, respectively, significantly higher than that in the control group, which was 2,425.34 u/g Hb (P < 0.05). Level of LPO was 19.38 and 17.09 micromol/L in high- and low-dose exposed groups, respectively, significantly higher than that in the control group, which was 4.37 micromol/L (P < 0.05).


CONCLUSIONS
Occupational long-term exposure to CS(2) could induce reduction of NO level in the body with its mechanism related to increase of super-oxygen cation O(2)(*-) induced by CS(2).
Jiang
X
X
Laboratory of Occupational Poisoning, Medical College of Zhejiang University, Hangzhou 310031, China.
Jiann
L
L
Hu
D
D
D000293:Adolescent; D000328:Adult; D002246:Carbon Disulfide / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D016273:Occupational Exposure / Q000009:adverse effects*; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult
D008054:Lipid Peroxides; D009569:Nitric Oxide; D013482:Superoxide Dismutase; D002246:Carbon Disulfide