[The relationship of low density lipoprotein receptor gene polymorphism and hyperlipidemia].
OBJECTIVE
To study the relationship of low density lipoprotein receptor gene polymorphism and hyperlipidemia in the population with essential hypertension.


METHODS
People with different lipid levels including 107 hyperlipidemia, 104 at margin level and 108 normal were recruited in the study. Their polymorphisms of LDL-R gene were analyzed using PCR-RFLP.


RESULTS
There were three kinds of genotype: (+/+), (+/-), (-/-). In male, the frequencies of the (+/-) in three study groups were shown as follows: 41.18% in hyperlipidemia, 46.15% in margin level, 19.05% in normal lipid. The frequency of (+) allele was significantly higher in hyperlipidemia than that in normal lipid (24.51%, 25.00% and 11.11%, respectively). In women, the differences were not statistically significant. The nonconditional univariate and multivariate logistic regression analysis demonstrated that (+) allele of Ava II polymorphism of LDL-R was a genetic marker of male's hypercholesterolemia.


CONCLUSIONS
The frequency of (+/-) hyperlipidemia in males was higher than that in normal lipid group and the (+) allele in male hyperlipidemia was significantly more frequent seen than that in normal lipid group. These results suggested that polymorphisms of LDL-Rgene might play an independent role of risk factor for hyperlipidemia.
Liu
A
A
Department of Epidemiology, Beijing Medical University, China.
Zhan
S
S
Li
L
L
D005260:Female; D005838:Genotype; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000235:genetics*; D006973:Hypertension / Q000150:complications*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011973:Receptors, LDL / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors
D011973:Receptors, LDL