title: Mechanisms of acute gain and late lumen loss after atherectomy in different preintervention arterial remodeling patterns.
abstract: The main mechanism of restenosis after directional coronary atherectomy (DCA) remains obscure. We investigated mechanisms of restenosis after DCA in different coronary artery remodeling patterns. DCA was performed in 51 de novo lesions. The lesions were evaluated by intravascular ultrasound (IVUS) before, immediately after, and 6 months after the procedure. According to the IVUS findings before DCA, we classified the lesions into the following 3 groups: (1) positive (n = 10), (2) intermediate (n = 25), and (3) negative (n = 16) remodeling. We measured lumen area, vessel area, and plaque area using IVUS before DCA, immediately after DCA, and at follow-up. Lumen area increase after DCA was mainly due to plaque area reduction in the positive and intermediate remodeling groups (90 plus minus 15% and 80 plus minus 25% increase in lumen area, respectively), whereas that in the negative remodeling group was due to both plaque area reduction (57 plus minus 22% increase in lumen area) and vessel area enlargement (43 plus minus 33% increase in lumen area). The plaque area increase correlated strongly with late lumen area loss in the positive and intermediate remodeling groups (r = 0.884, p <0.001; r = 0.626, p <0.001, respectively), but the decrease in vessel area was not correlated with lumen area loss. In contrast, both an increase in plaque area and a decrease in vessel area were correlated with late lumen area loss (r = 0.632, p = 0.009; r = 0.515, p = 0.041) in the negative remodeling group. Coronary artery restenosis after atherectomy was primarily due to an increase in plaque in the positive and/or intermediate remodeling groups. However, in the negative remodeling group, late lumen loss might have been caused by both an increase in plaque and vessel shrinkage.
authors.affiliation: Department of Cardiology, The Cardiovascular Institute, Tokyo, Japan. oikawa@fmu.ac.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Oikawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Kirigaya
authors.forename: Tadanori
authors.initials: T
authors.lastname: Aizawa
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Nagashima
authors.forename: Junji
authors.initials: J
authors.lastname: Yajima
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Ishimura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hara
authors.forename: Makoto
authors.initials: M
authors.lastname: Sahara
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iinuma
authors.forename: Long Tai
authors.initials: LT
authors.lastname: Fu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017225:Atherectomy, Coronary; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis; D003327:Coronary Disease / Q000601:surgery*; D023903:Coronary Restenosis / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis*; D018084:Ultrasonography, Interventional