title: [Pituitary function after transsphenoidal surgery for pituitary adenoma].
abstract: Nowadays transsphenoidal surgery is the method of choice in most cases of pituitary adenoma treatment, both functioning and non-functioning. This method is considered to be safer than transcranial approach, as lower incidence of complications, particularly hypopituitarism, is observed. The aim of the study was to evaluate the pituitary function after transsphenoidal surgery. 20 patients (mean age 49.3 +/- 13.9 years) were included into the study. The anterior pituitary insufficiency was defined as an inadequate excretory response to metopirone, LH-RH and TRH stimulation. Diabetes insipidus was diagnosed based on clinical symptoms. Hypopituitarism was diagnosed after surgery in 7 patients, 3 cases had adrenal and gonadal insufficiency, 1 patient had insufficiency of the pituitary-thyroid and gonadal axis and 3 subjects panhypopituitarism. Diabetes insipidus was still present in 2 patients, 3 months after surgery. We conclude that transsphenoidal approach in pituitary adenoma surgery is connected with low risk of iatrogenic hypopituitarism.
authors.affiliation: Katedra i Klinika Endokrynologii CMUJ ul. Kopernika 17, 31-501 Kraków. filgol@endo.cm-uj.krakow.pl
authors.forename: F
authors.initials: F
authors.lastname: Gołkowski
authors.forename: M
authors.initials: M
authors.lastname: Trofimiuk
authors.forename: B
authors.initials: B
authors.lastname: Huszno
authors.forename: A
authors.initials: A
authors.lastname: Bałdys-Waligórska
authors.forename: Z
authors.initials: Z
authors.lastname: Szybiński
authors.forename: R
authors.initials: R
authors.lastname: Czepko
authors.forename: B
authors.initials: B
authors.lastname: Danilewicz
mesh_terms: D000236:Adenoma / Q000503:physiopathology* / Q000601:surgery; D000328:Adult; D003919:Diabetes Insipidus / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007016:Hypophysectomy / Q000009:adverse effects* / Q000379:methods; D007018:Hypopituitarism / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000503:physiopathology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000503:physiopathology* / Q000601:surgery