The use of naloxone in small doses in complex therapy of postabstinent heroin syndrome: enkephalinase mechanisms.
The use of naloxone hydrochloride (0.2-0.4 mg) in complex therapy of adolescent heroin addicts significantly prolonged the half-life of serum leu-enkephalin, slightly elevated the thresholds of thermal nociceptive reactions, and improved some clinical indices (considerably reduced drug addiction, eliminated affective disorders, etc.), which are important for deactualization of drug addiction and promoting remission.
Litvinova
S V
SV
Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov Moscow State University. shulg@protein.bio.msu.ru
Nadezhdin
A V
AV
Shul'govskii
V V
VV
Kalyuzhnyi
A L
AL
Avdeev
S N
SN
Tetenova
E Y
EY
Terebilina
N N
NN
Panchenko
L F
LF
D000293:Adolescent; D000367:Age Factors; D003932:Heroin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D019966:Substance-Related Disorders; D013696:Temperature; D013997:Time Factors
D009292:Narcotic Antagonists; D009270:Naloxone; D003932:Heroin