title: Antithrombotic lipid minor constituents from vegetable oils. Comparison between olive oils and others.
abstract: Many epidemiological studies suggest that vegetable oils and especially olive oil present a protective effect against atherosclerosis. In this study, total lipids (TL) of Greek olive oils and seed oils of four kinds, namely, soybean, corn, sunflower, and sesame oil, were separated into total polar lipids (TPL) and total neutral lipids (TNL) via a novel extraction procedure. TPL and TNL of olive oil were fractionated by HPLC for further study. Each lipid fraction from HPLC separation along with TL, TPL, and TNL lipid samples from oils were tested in vitro for their capacity to induce or to inhibit washed rabbit platelet aggregation. Comparison between olive and seed oils supports the superiority of olive oil as high levels of platelet activating factor (PAF) antagonists have been detected, mainly in TPL. In addition, the structure of the most active fraction from olive oil was elucidated, as a glycerol-glycolipid. Because it has already been reported that PAF plays a pivotal role in atherogenesis, the existence of PAF agonists and antagonists in vegetable oils may explain their protective role against atherosclerosis.
authors.affiliation: Faculty of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis, 15771 Athens, Greece.
authors.forename: Haralabos C
authors.initials: HC
authors.lastname: Karantonis
authors.forename: Smaragdi
authors.initials: S
authors.lastname: Antonopoulou
authors.forename: Constantinos A
authors.initials: CA
authors.lastname: Demopoulos
mesh_terms: D000107:Acetylation; D002240:Carbohydrate Sequence; D003314:Corn Oil / Q000737:chemistry; D005343:Fibrinolytic Agents / Q000032:analysis*; D006115:Greece; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008055:Lipids / Q000032:analysis*; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry; D000069463:Olive Oil; D010938:Plant Oils / Q000737:chemistry*; D012715:Sesame Oil / Q000737:chemistry; D013025:Glycine max; D021241:Spectrometry, Mass, Electrospray Ionization; D000074242:Sunflower Oil
chemical_list: D005343:Fibrinolytic Agents; D008055:Lipids; D009844:Oligosaccharides; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil; D003314:Corn Oil; D012715:Sesame Oil