title: Steroids in sepsis--more effective than activated protein C?
abstract: Early studies using high doses of steroids in septic shock resulted in increased mortality. More recently, work by Annane et al. using lower doses closer to those that might constitute a stress dose of hydrocortisone have shown encouraging results with a 30% decrease in mortality in septic shock. Although this result is more impressive than the reduction in mortality resulting from the use of activated protein C in septic shock, the numbers of patients involved in the steroid study are low and the results remain unpublished in a peer-reviewed journal.
authors.affiliation: St. George's Hospital, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Bradley
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005438:Fludrocortisone / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D011486:Protein C / Q000627:therapeutic use; D012772:Shock, Septic / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D011486:Protein C; D005438:Fludrocortisone; D006854:Hydrocortisone