Renal function in children with sickle cell anemia.
BACKGROUND
Patients with sickle cell anemia have various forms of renal dysfunction.


METHODS
The purpose of this study is to demonstrate the abnormalities of HbSS patients' renal function in childhood. Renal function studies were performed in 55 patients with homozygote sickle cell anemia and compared with 13 healthy children. The blood and timed urine samples were obtained for hematological and biochemical determinations.


RESULTS
Mean serum creatinine, sodium, phosphorus and calcium levels were not statistically different between patients and controls. Mean serum potassium and uric acid levels were significantly higher in patients than in controls. Mean tubular phosphate reabsorption (p < 0.001) and fractional excretion of potassium (p < 0.05) were lower in patients than in the control. There were no significant differences in fractional excretion of sodium and uric acid between patients and controls. Patients had significantly higher urine pH and significantly lower specific gravity and osmolality than controls. Also, there were no significant differences in urinary protein/ creatinine, urinary N-acetyl-beta-D-glucosaminidase/creatinine and urinary malondialdehyde/creatinine between patients and controls.


CONCLUSIONS
Thus, significant proximal tubular dysfunction is not a common feature but distal tubular abnormality is the most consistent renal functional derangement of patients with SCA in childhood.
Bayazit
A Karabay
AK
Department of Pediatric Nephrology, Cukurova University School of Medicine, Balcali, Adana, Turkey.
Noyan
A
A
Aldudak
B
B
Ozel
A
A
Anarat
A
A
Kilinç
Y
Y
Sasmaz
Gali
E
E
Anarat
R
R
Dikmen
N
N
D000755:Anemia, Sickle Cell / Q000503:physiopathology*; D001806:Blood Urea Nitrogen; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007686:Kidney Tubules, Distal / Q000503:physiopathology; D008297:Male; D008315:Malondialdehyde / Q000652:urine; D011188:Potassium / Q000097:blood; D011507:Proteinuria; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D008315:Malondialdehyde; D003404:Creatinine; D011188:Potassium