title: [Treatment of acute experimental diphtheria toxemia by immunohemosorption].
abstract: The antitoxic antidiphtheric immunosorbent DATs was tested in experiments on mice and guinea-pigs using the model of acute diphtheric toxemia. In extracorporeal connecting with the circulation system of the animals the sorbent effectively bound and eliminated from the circulation molecules of diphtheric toxin and antitoxin, reduced significantly their levels in the blood after hemoperfusion. The effectiveness of the immunosorbent DATs was confirmed when it saved the ginea-pigs after injection of lethal toxin doses.
authors.forename: S I
authors.initials: SI
authors.lastname: Kuznetsov
authors.forename: L N
authors.initials: LN
authors.lastname: Barashkova
authors.forename: E V
authors.initials: EV
authors.lastname: Nosikova
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Korosteleva
authors.forename: P A
authors.initials: PA
authors.lastname: Kanaev
authors.forename: N V
authors.initials: NV
authors.lastname: Burkova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Eĭsmont
authors.forename: A I
authors.initials: AI
authors.lastname: Tiukavin
mesh_terms: D000208:Acute Disease; D000818:Animals; D004165:Diphtheria / Q000097:blood / Q000188:drug therapy*; D004166:Diphtheria Antitoxin / Q000627:therapeutic use; D004167:Diphtheria Toxin / Q000008:administration & dosage* / Q000097:blood*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006464:Hemoperfusion; D008297:Male; D051379:Mice
chemical_list: D004166:Diphtheria Antitoxin; D004167:Diphtheria Toxin