title: Asymmetric total synthesis of (+)-brefeldin A from (S)-lactate by triple chirality transfer process and nitrile oxide cycloaddition.
abstract: A novel synthesis of (+)-brefeldin A (1) has been accomplished on the basis of triple chirality transfer methodology, intramolecular ester enolate alkylation, and both intra- and intermolecular nitrile oxide cycloaddition strategies.
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, San 56-1, Shillim-Dong, Kwanak-Ku, Seoul 151-742, Korea. deukjoon@plaza.snu.ac.kr
authors.forename: Deukjoon
authors.initials: D
authors.lastname: Kim
authors.forename: Jongkook
authors.initials: J
authors.lastname: Lee
authors.forename: Phil Jong
authors.initials: PJ
authors.lastname: Shim
authors.forename: Joong Inn
authors.initials: JI
authors.lastname: Lim
authors.forename: Hyunil
authors.initials: H
authors.lastname: Jo
authors.forename: Sanghee
authors.initials: S
authors.lastname: Kim