[Chemoprevention of colorectal cancer].
A NEW CONCEPT: Chemoprevention of cancer consists in the administration of chemical agents to prevent or inhibit carcinogenesis. This strategy can be applied at any stage of carcinogenesis.


RESULTS
The development of such agents relies on classical bases: phases I, II and III. The approach consists in assessing the effect of the substance tested in patients with history of resected adenomas of the colon and at high risk of relapse and/or family risk of colon cancer.
Are aspirin, type 2 cyclo-oxygenase inhibitors, calcium, folic acid, certain vitamins, hormone replacement therapy for menopausal women and difluoromethylornithine (DFMO).
Benamouzig
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Service d'Hépato-gastroentérologie, Hôpital Avicenne, 125, rue de Stalingrad, F93000 Bobigny.
Chaussade
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D011125:Adenomatous Polyposis Coli / Q000517:prevention & control; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D002136:Calcium, Dietary / Q000627:therapeutic use; D016022:Case-Control Studies; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D018849:Controlled Clinical Trials as Topic; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D019587:Dietary Supplements; D000518:Eflornithine / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D020249:Hormone Replacement Therapy; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008875:Middle Aged; D012307:Risk Factors; D013467:Sulindac / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D014815:Vitamins / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D002136:Calcium, Dietary; D016861:Cyclooxygenase Inhibitors; D004791:Enzyme Inhibitors; D014815:Vitamins; D013467:Sulindac; D005492:Folic Acid; D001241:Aspirin; D000518:Eflornithine