[Primary study on immunologic effect of live attenuated hepatitis A vaccine (H2 strain) after booster dose].
OBJECTIVE
To study the immunologic effect of live attenuated hepatitis A vaccine (H(2) Strain, 10(7.0)TCID(50)) after booster and to compare with the results of 1 dose live attenuated hepatitis A vaccine (H(2) Strain, 10(7.0)TCID(50)).


METHODS
42 susceptibles with negative anti - HAV were selected in Zhengding, Hebei province. Each subject received 3 doses live attenuated hepatitis A vaccine at 0, 2, 6 months and was bled at 1, 2, 6, 7, 9, 12 months after vaccination.


RESULTS
The seroconversion rate at 1 month after the first dose was 81.4% and reached 100% after the second dose. GMT arrived the peak 2,739 mIU/ml at one month after the third dose, before stared declining. The seroconversion rate kept 100% at 12 months after the first dose, but GMT decreased to 979 mIU/ml.


CONCLUSIONS
The first dose worked as the base of boostering. A booster dose of live attenuated hepatitis A vaccine could induce secondary immune response well. The immunologic effect after booster dose could match the effect with inactivated vaccine and was better than the results of 1 dose live attenuated hepatitis A vaccine. The program seemed to be useful to the protective effect and the immuno - persistence.
Wang
X
X
Shanghai Medical University, Shanghai 200032, China.
Ma
J
J
Zhang
Y
Y
Zhang
Y
Y
Han
C
C
Xing
Z
Z
Chen
J
J
Zhang
Y
Y
Zhao
S
S
Gu
H
H
Xu
Z
Z
D002648:Child; D005260:Female; D022362:Hepatitis A Vaccines / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D015164:Vaccines, Inactivated / Q000276:immunology
D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies; D015164:Vaccines, Inactivated