[Evaluation of reactogenicity and immunogenicity of Bubo-M, the Russian combined vaccine for immunization of adults against diphtheria, tetanus and viral hepatitis B].
Bubo-M, the first Russian associated vaccine, was found to have low reactogenicity and high immunogenic potency. The frequency of postvaccinal reactions in the group of persons immunized with Bubo-M (20%) appeared to be considerably lower than among persons who received the combined injection of adsorbed DT toxoid with reduced antigen content and vaccine against hepatitis B (47.7%). Following the course of vaccination the level of anti-HBs considerably exceeded the protective level. Immune response to the diphtheria and tetanus components of Bubo-M exceeded that observed after immunization with absorbed DT toxoid with reduced antigen content (p < 0.05).
Fel'dblium
I V
IV
Medical Academy, Perm, Russia.
Vorob'eva
N N
NN
Nikolaeva
A M
AM
Borisova
V N
VN
Mel'nikov
V A
VA
Budanov
M V
MV
Iakovleva
I A
IA
Kaz'ianin
A V
AV
Pushkareva
E V
EV
Griaznova
D V
DV
Shalunova
N V
NV
Perelygina
O V
OV
Ozeretskovskiĭ
N A
NA
Bektimirov
T A
TA
Isaeva
N V
NV
D000293:Adolescent; D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology; D022422:Diphtheria-Tetanus Vaccine / Q000276:immunology*; D006511:Hepatitis B Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D012426:Russia; D014611:Vaccination / Q000009:adverse effects; D017778:Vaccines, Combined / Q000276:immunology
D000942:Antigens, Bacterial; D022422:Diphtheria-Tetanus Vaccine; D006511:Hepatitis B Antigens; D017325:Hepatitis B Vaccines; D017778:Vaccines, Combined