The role of growth hormone in T-cell development and reconstitution.
Growth hormone (GH), directly or through GH-induction of insulin-like growth factor (IGF)-1, has been implicated in lymphocyte development and function. Recent studies have questioned the role of GH and IGF-1 in immune responses. This review examines experimental data describing the immunoregulatory function of GH and attempts to reconcile the literature.
Welniak
Lisbeth A
LA
Laboratory of Immunoregulation, NCI-Frederick, SAIC, Frederick, Maryland 21702, USA.
Sun
Rui
R
Murphy
William J
WJ
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology / Q000502:physiology; D013006:Growth Hormone / Q000502:physiology*; D019382:Human Growth Hormone / Q000502:physiology; D006801:Humans; D051381:Rats; D011986:Receptors, Somatotropin / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology / Q000502:physiology
D011986:Receptors, Somatotropin; D019382:Human Growth Hormone; D013006:Growth Hormone