Does BDNF have pre- or postsynaptic targets?
A type of synaptic plasticity in the brain called long-term potentiation (LTP) is thought to form the molecular basis of learning and memory. In a Perspective, Manabe discusses new findings (Kovalchuk et al.) showing brain-derived neurotropic factor modulates LTP by binding to TrkB receptors on the postsynaptic neuron.
Manabe
Toshiya
T
Division of Cell Biology and Neurophysiology, Department of Neuroscience, Faculty of Medicine, Kobe University, Kobe 650-0017, Japan. tmanabe-tky@umin.ac.jp
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism* / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling; D018891:Dentate Gyrus / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D004594:Electrophysiology; D018698:Glutamic Acid / Q000378:metabolism; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D020813:Receptor, trkB / Q000378:metabolism*; D015222:Sodium Channels / Q000378:metabolism; D013569:Synapses / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects
D019208:Brain-Derived Neurotrophic Factor; D015220:Calcium Channels; D015222:Sodium Channels; D018698:Glutamic Acid; D020813:Receptor, trkB; D002118:Calcium