Interferon-beta increases the stimulatory capacity of monocyte-derived dendritic cells to induce IL-13, IL-5 and IL-10 in autologous T-cells.
Dendritic cells (DCs) are key regulators of immune responses and have been associated with autoimmunity in animal models and human disease. The effects of interferon beta (IFN-beta), an immunomodulatory cytokine used in multiple sclerosis (MS) therapy, on DCs are not well understood. Monocyte-derived DCs at different stages of maturation were stimulated with IFN-beta and DC-phenotype and stimulatory function were measured. IFN-beta inhibited the development of DCs at early stages but enhanced DC maturation. Moreover, IFN-beta enhanced the capacity of DCs to stimulate autologous T-cells to secrete IL-13, IL-10 and IL-5. Thus, IFN-beta has both immunostimulatory and immunosuppressive effects on DCs depending on the stage of maturation.
Wiesemann
Elke
E
Department of Neurology, Medical School Hannover, Carl-Neuberg-Strasse 1, D-30623, Hannover, Germany.
Sönmez
Daniela
D
Heidenreich
Fedor
F
Windhagen
Anja
A
D018949:Antigens, CD1 / Q000096:biosynthesis; D003713:Dendritic Cells / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D016167:Integrin alphaXbeta2 / Q000096:biosynthesis; D016899:Interferon-beta / Q000494:pharmacology*; D016753:Interleukin-10 / Q000096:biosynthesis*; D018793:Interleukin-13 / Q000096:biosynthesis*; D015848:Interleukin-5 / Q000096:biosynthesis*; D009000:Monocytes / Q000502:physiology*; D017471:Receptors, Interferon / Q000032:analysis; D013601:T-Lymphocytes / Q000378:metabolism*
D018949:Antigens, CD1; C419393:CD1a antigen; D016167:Integrin alphaXbeta2; D018793:Interleukin-13; D015848:Interleukin-5; D017471:Receptors, Interferon; D016753:Interleukin-10; D016899:Interferon-beta