Cbl and Cbl-b in T-cell regulation.
Genetic studies indicate that Cbl and Cbl-b, two highly homologous adaptor proteins, are involved in the negative regulation of thymocyte development and peripheral T-cell activation, respectively. The recent identification of Cbl proteins as RING-type E3 ubiquitin ligases might provide insights into their distinct immune regulatory functions, involving the targeting of different substrates for ubiquitination. The structural similarity and ubiquitous expression of Cbl and Cbl-b suggest, however, that they might also have overlapping functions in setting the thresholds for thymocyte selection and mature T-cell signaling.
Liu
Yun-Cai
YC
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA. yuncail@liai.org
Gu
Hua
H
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D002352:Carrier Proteins / Q000378:metabolism*; D015536:Down-Regulation; D008025:Ligases / Q000378:metabolism; D051379:Mice; D018448:Models, Immunological; D010750:Phosphoproteins / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D050721:Proto-Oncogene Proteins c-cbl; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D044767:Ubiquitin-Protein Ligases
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C118387:Cblb protein, mouse; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D050721:Proto-Oncogene Proteins c-cbl; D044767:Ubiquitin-Protein Ligases; D008025:Ligases; C493849:Cbl protein, mouse