title: Improvement of both psychotic symptoms and Parkinsonism in a case of dementia with Lewy bodies by the combination therapy of risperidone and L-DOPA.
abstract: A 69-year-old female of dementia with Lewy bodies (DLB) with fluctuating cognitive impairment, visual and auditory hallucinations, persecutory delusions and Parkinsonism was treated by the combination of 1 mg/day risperidone and 300-750 mg/day L-DOPA. By this combination therapy, both the psychotic symptoms and Parkinsonism improved, while cognitive function did not deteriorate. This report suggests that the combination therapy of risperidone and L-DOPA may be worth considering in the special cases of DLB.
authors.affiliation: Department of Neuropsychiatry, Yamagata University School of Medicine, Japan.
authors.forename: Kimiyasu
authors.initials: K
authors.lastname: Kato
authors.forename: Tadashi
authors.initials: T
authors.lastname: Wada
authors.forename: Shinobu
authors.initials: S
authors.lastname: Kawakatsu
authors.forename: Koichi
authors.initials: K
authors.lastname: Otani
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D020961:Lewy Body Disease / Q000188:drug therapy* / Q000473:pathology / Q000523:psychology*; D008279:Magnetic Resonance Imaging; D018967:Risperidone / Q000627:therapeutic use*
chemical_list: D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D007980:Levodopa; D018967:Risperidone