A review of emergency foot-and-mouth disease (FMD) vaccines.
The primary objectives of this paper are to describe emergency foot-and-mouth disease (FMD) vaccines and review literature on emergency vaccine efficacy to protect animals against (1) clinical signs and (2) infection (local virus replication). The reviewed experiments suggest that in cattle, sheep and pigs, the vaccine could be effective in preventing disease within 4-5 days post-vaccination. These studies also suggest that the risk of spreading infection decreases as the interval between vaccine and challenge increases and that vaccination could reduce the amount of virus excreted compared to non-vaccinated animals. We suggest areas of future research to improve our knowledge of emergency vaccines.
Barnett
P V
PV
Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK. paul.barnett@bbsrc.ac.uk
Carabin
H
H
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002353:Carrier State / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control; D004630:Emergencies; D005536:Foot-and-Mouth Disease / Q000276:immunology / Q000517:prevention & control*; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology / Q000502:physiology; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000517:prevention & control; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control; D014765:Viral Vaccines / Q000494:pharmacology*; D014766:Viremia / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary; D014779:Virus Replication
D000914:Antibodies, Viral; D014765:Viral Vaccines