[Treatment of acute experimental diphtheria toxemia by immunohemosorption].
The antitoxic antidiphtheric immunosorbent DATs was tested in experiments on mice and guinea-pigs using the model of acute diphtheric toxemia. In extracorporeal connecting with the circulation system of the animals the sorbent effectively bound and eliminated from the circulation molecules of diphtheric toxin and antitoxin, reduced significantly their levels in the blood after hemoperfusion. The effectiveness of the immunosorbent DATs was confirmed when it saved the ginea-pigs after injection of lethal toxin doses.
Kuznetsov
S I
SI
Barashkova
L N
LN
Nosikova
E V
EV
Korosteleva
Iu G
IuG
Kanaev
P A
PA
Burkova
N V
NV
Eĭsmont
Iu A
IuA
Tiukavin
A I
AI
D000208:Acute Disease; D000818:Animals; D004165:Diphtheria / Q000097:blood / Q000188:drug therapy*; D004166:Diphtheria Antitoxin / Q000627:therapeutic use; D004167:Diphtheria Toxin / Q000008:administration & dosage* / Q000097:blood*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006464:Hemoperfusion; D008297:Male; D051379:Mice
D004166:Diphtheria Antitoxin; D004167:Diphtheria Toxin