title: Bone grafts and growth and differentiation factors for regenerative therapy: a review.
abstract: Guided bone regeneration, tissue grafts, regenerative barrier membranes, and bone substitute materials have been used to restore inadequate hard and soft tissue structures to make them conducive to proper implant placement. Polypeptide growth and development factors (GDFs) have successfully been applied exogenously to periodontal defects to attract preosteoblasts to the site and accelerate their proliferation to stimulate angiogenesis. This article provides an overview of current modalities for restoring lost bone and soft tissue during the treatment of periodontal disease.
authors.affiliation: University of Pennsylvania School of Dental Medicine, MCP/Hahnemann School of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: L F
authors.initials: LF
authors.lastname: Rose
authors.forename: E
authors.initials: E
authors.lastname: Rosenberg
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation; D002455:Cell Division; D002465:Cell Movement; D015921:Dental Implants; D006133:Growth Substances / Q000627:therapeutic use*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use; D008567:Membranes, Artificial; D018919:Neovascularization, Physiologic / Q000502:physiology; D013516:Oral Surgical Procedures, Preprosthetic / Q000379:methods*; D010006:Osteoblasts / Q000502:physiology; D010510:Periodontal Diseases / Q000601:surgery; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use; D016212:Transforming Growth Factor beta / Q000627:therapeutic use; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D015921:Dental Implants; D006133:Growth Substances; D008567:Membranes, Artificial; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; D007334:Insulin-Like Growth Factor I