Iron content and parameters of blood antioxidant activity in rats with hereditary arterial hypertension during experimental myocardial infarction.
Plasma, lymph and myocardial Fe(2+) contents and blood antioxidant activity were studied in hypertensive NISAG and normotensive Wistar rats with experimental myocardial infarction. In hypertensive rats, iron levels in plasma, lymph and myocardial tissue were increased throughout the experiment. In both strains iron content in the plasma during experimental myocardial infarction negatively correlated with blood antioxidant activity. In hypertensive NISAG rats this correlation persisted also during recovery. This attests to prooxidant effect of Fe(2+) aggravating the course of myocardial infarction in NISAG rats.
Yakobson
M G
MG
Institute of Physiology, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Antonov
A R
AR
Golovatyuk
A V
AV
Efremov
A V
AV
Markel'
A L
AL
Yakobson
G S
GS
D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D006973:Hypertension / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D008198:Lymph Nodes / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000975:Antioxidants; D007501:Iron