Determination of arsenic in homeopathic drugs by bromide volatilization-inductively coupled plasma-atomic emission spectrometry.
Arsenic in homeopathic drugs was determined by coupling a volatile generation with inductively coupled plasma-atomic emission spectrometry. The method is based on the chemical vaporization of arsenic(III) with bromide ions in sulfuric acid media using a batch procedure and subsequent introduction of the gaseous analyte into the plasma torch. The main and interactive effects of the experimental variables affecting this method were evaluated by a 2-level full factorial design. In optimized conditions by Simplex, the method shows an absolute detection limit (3 s) of 0.28 microg for the injection of 230 microL sample. The precision (% relative standard deviation) of the determination was 4.2% at a level of 50 microg/mL As(III) (n = 5). The interference effect of various ions on the arsenic signal was evaluated.
Lopez-Molinero
Angel
A
University of Zaragoza, Faculty of Science, Department of Analytical Chemistry, Spain. anlopez@posta.unizar.es
Villareal
Anselmo
A
Velilla
Cesar
C
Andía
David
D
Castillo
Juan R
JR
D001151:Arsenic / Q000032:analysis*; D001965:Bromides / Q000737:chemistry; D002138:Calibration; D017022:Flow Injection Analysis; D006705:Homeopathy; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011042:Poisons / Q000032:analysis*; D015203:Reproducibility of Results; D013054:Spectrophotometry, Atomic; D014835:Volatilization
D001965:Bromides; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D011042:Poisons; D001151:Arsenic