title: Ethical considerations on preimplantation genetic diagnosis for HLA typing to match a future child as a donor of haematopoietic stem cells to a sibling.
abstract: Recently, several requests were made by couples with an affected child who wanted preimplantation genetic diagnosis (PGD) to select embryos in the hope of conceiving an HLA identical donor sibling. This article considers the ethical arguments for and against the application of PGD for this goal. Only embryos HLA matched with an existing sibling in need of a compatible donor of haematopoietic stem cells would be transferred. The main arguments are the instrumentalization of the child, the best-interests standard, the postnatal test for acceptability and the experience of the donor child. It is argued that conceiving a child to save a child is a morally defensible decision on the condition that the operation that will be performed on the future child is acceptable to perform on an existing child. The instrumentalization of the donor child does not demonstrate disrespect for its autonomy or its intrinsic worth.
authors.affiliation: Department of Philosophy, Lok. 5 C 442, Academic Hospital, Free University Brussels, Pleinlaan 2, B-1050 Brussels, Belgium. gpenning@vub.ac.be
authors.forename: G
authors.initials: G
authors.lastname: Pennings
authors.forename: R
authors.initials: R
authors.lastname: Schots
authors.forename: I
authors.initials: I
authors.lastname: Liebaers
mesh_terms: D004992:Ethics, Medical; D006680:HLA Antigens / Q000145:classification*; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D019836:Preimplantation Diagnosis; D014019:Tissue Donors
chemical_list: D006680:HLA Antigens