title: Both R5 and X4 human immunodeficiency virus type 1 variants persist during prolonged therapy with five antiretroviral drugs.
abstract: A viral reservoir of human immunodeficiency virus type 1 (HIV-1)-infected, resting CD4(+) T cells persists despite suppression of plasma viremia by combination antiretroviral therapy. In a longitudinal analysis of three patients treated with a five-drug regimen, both R5 and X4 HIV-1 variants persisted in the cellular reservoir for up to 3 years.
authors.affiliation: Department of Clinical Viro-Immunology, CLB/Sanquin and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands.
authors.forename: Ronald P
authors.initials: RP
authors.lastname: van Rij
authors.forename: Janny A
authors.initials: JA
authors.lastname: Visser
authors.forename: Rieneke M E
authors.initials: RM
authors.lastname: van Praag
authors.forename: Ronald
authors.initials: R
authors.lastname: Rientsma
authors.forename: Jan M
authors.initials: JM
authors.lastname: Prins
authors.forename: Joep M A
authors.initials: JM
authors.lastname: Lange
authors.forename: Hanneke
authors.initials: H
authors.lastname: Schuitemaker
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D002460:Cell Line; D018920:Coculture Techniques; D004359:Drug Therapy, Combination; D014644:Genetic Variation; D015726:Giant Cells; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D017422:Sequence Analysis, DNA; D013997:Time Factors; D019562:Viral Load; D014766:Viremia / Q000821:virology
chemical_list: D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors