Effects of per os lead acetate administration on mouse hepatocyte survival.
Previously published studies indicate that hepatotoxicity is associated with high blood lead (Pb) levels in animal models and humans. The present investigation evaluated the effects of in vivo Pb exposure via drinking water on mouse hepatocyte survival in vitro when blood Pb concentrations reflected those seen in children in urban and rural settings (2-15 microg/dl). The findings indicated a biphasic dose-response with low concentrations associated with a modest decrease in hepatocyte survival, while at the highest concentration, survival was significantly enhanced (60%). Since these responses were associated with concentrations normally encountered by children, follow-up investigations are warranted.
Iavicoli
I
I
School of Medicine, Institute of Occupational Health, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Roma, Italy.
Carelli
G
G
Stanek
E J
EJ
Castellino
N
N
Calabrese
E J
EJ
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004326:Drinking; D005260:Female; D022781:Hepatocytes / Q000187:drug effects* / Q000502:physiology; D007854:Lead / Q000097:blood; D051379:Mice; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000633:toxicity*
D009942:Organometallic Compounds; D007854:Lead; C008261:lead acetate