[Investigation of the pharmacodynamic properties of the solution of boric acid].
By virtue of experimental investigations that had been carried out on animals an essential biological action of the aqueous solution of boric acid on the organism could be stated. The solution containing 274.46 mg of H3BO3 in a litre, administered to rats for 30 days orally in an "ad libitum" dose, caused changes in the lipid metabolism and in the water-mineral balance of the organism and in the acid-base equilibrium of the blood, it did not affect the morphology and the parameters of carbohydrate and protein metabolism. No influence has been stated of the investigated boric acid, as used in guinea pigs, on the excretion of bile. Suitably diluted with a nutritive fluid the solution acted spastically on the peristalsis of the small intestine of the rabbit.
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Zakład Tworzyw Uzdrowiskowych, Państwowy Zakład Higieny, 60-821 Poznań, ul. Słowackiego 8/10.
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D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D001888:Boric Acids / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000097:blood; D006168:Guinea Pigs; D007421:Intestine, Small / Q000187:drug effects; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D011044:Poland; D011506:Proteins / Q000378:metabolism*; D011817:Rabbits; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D001888:Boric Acids; D002241:Carbohydrates; D008055:Lipids; D011506:Proteins