The SAP family: a new class of adaptor-like molecules that regulates immune cell functions.
EAT-2 is a member of a newly described adaptor-like protein family consisting, at the moment, of EAT-2 and the signaling lymphocytic-activation molecule (SLAM)-associated protein (SAP). Both proteins are expressed in immune cells and can bind to members of the SLAM family of immune receptors. However, differences between the two proteins exist. There appears to be little overlap in the types of immune cells that express SAP and EAT-2, and the Src homology 2 (SH2) domain of SAP can bind to unphosphorylated tyrosines, whereas the SH2 domain of EAT-2 cannot. Veillette discusses new findings on the functions of EAT-2 and SAP and how they might regulate signals emanating from the SLAM family of receptors.
Veillette
André
A
Laboratory of Molecular Oncology, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada. veillea@ircm.qc.ca
D000276:Adjuvants, Immunologic / Q000502:physiology*; D000818:Animals; D015703:Antigens, CD; D002352:Carrier Proteins / Q000502:physiology*; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology / Q000502:physiology; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics / Q000276:immunology / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D005810:Multigene Family / Q000276:immunology*; D011956:Receptors, Cell Surface; D015398:Signal Transduction / Q000276:immunology; D000071179:Signaling Lymphocytic Activation Molecule Associated Protein; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1
D000276:Adjuvants, Immunologic; D015703:Antigens, CD; D002352:Carrier Proteins; D006023:Glycoproteins; D007136:Immunoglobulins; D047908:Intracellular Signaling Peptides and Proteins; D011956:Receptors, Cell Surface; C114953:SH2D1A protein, human; D000071179:Signaling Lymphocytic Activation Molecule Associated Protein; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1