title: Influence of root canal dressings and sealers on repair of apical periodontitis after endodontic treatment.
abstract: OBJECTIVE
  The objective of this study was to evaluate the histopathologic response of periapical tissues after root canal treatment of necrotic dog teeth with chronic apical periodontitis by using 2 calcium hydroxide-based root canal dressings and 2 root canal sealers.
  
  
  METHODS
  Seventy-eight root canals were instrumented by using 5.25% sodium hypochlorite as the irrigating solution, after which a calcium hydroxide paste (Calen/PMCC or Calasept) was placed for 30 days as a dressing. The root canals were then filled by using cold lateral gutta-percha condensation and an endodontic sealer (Sealapex or AH Plus). After 360 days, the animals were killed by anesthetic overdose; then, the teeth were histologically prepared, sectioned, and stained with hematoxylin and eosin for optical microscopic analysis of apical and periapical tissue repair.
  
  
  RESULTS
  Statistical analysis showed that the poorest histopathologic results were observed in the Calasept/AH Plus group and that the Sealapex sealer overall resulted in better apical repair than the AH Plus sealer. The histopathologic results of Calen/PMCC paste with both AH Plus and Sealapex and Calasept paste with only Sealapex were statistically similar but were different from the results of Calasept with AH Plus.
  
  
  CONCLUSIONS
  The results of this study in the dog showed differences in apical and periapical tissue repair of teeth with chronic apical periodontitis by using 2 calcium hydroxide root canal dressings and 2 sealers. More research is necessary to determine the best combination of dressings and sealers.
authors.affiliation: Department of Endodontics, School of Dentistry of Araraquara, University of the State of São Paulo, UNESP, Brazil.
authors.forename: Fábio Luiz Camargo Villela
authors.initials: FL
authors.lastname: Berbert
authors.forename: Mário Roberto
authors.initials: MR
authors.lastname: Leonardo
authors.forename: Léa Assed Bezerra
authors.initials: LA
authors.lastname: Silva
authors.forename: Mário
authors.initials: M
authors.lastname: Tanomaru Filho
authors.forename: Clóvis Monteiro
authors.initials: CM
authors.lastname: Bramante
mesh_terms: D000818:Animals; D002122:Calcium Chloride; D002126:Calcium Hydroxide / Q000494:pharmacology; D004285:Dogs; D004338:Drug Combinations; D004853:Epoxy Resins / Q000494:pharmacology; D010485:Periapical Periodontitis / Q000628:therapy*; D010486:Periapical Tissue / Q000187:drug effects*; D011189:Potassium Chloride; D011897:Random Allocation; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D012388:Root Canal Irrigants / Q000494:pharmacology*; D012390:Root Canal Therapy / Q000379:methods*; D012459:Salicylates / Q000494:pharmacology; D017693:Sodium Bicarbonate; D012965:Sodium Chloride; D018709:Statistics, Nonparametric; D014945:Wound Healing / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D004853:Epoxy Resins; D012387:Root Canal Filling Materials; D012388:Root Canal Irrigants; D012459:Salicylates; C036086:calcium hydroxide, calcium chloride, potassium chloride, sodium bicarbonate, sodium chloride drug combination; C420643:calen; C534916:epoxy resin-based root canal sealer; C055601:Sealapex; D012965:Sodium Chloride; D011189:Potassium Chloride; D017693:Sodium Bicarbonate; D002122:Calcium Chloride; D002126:Calcium Hydroxide