title: Response to thermal stimuli in skin pretreated with sodium lauryl sulfate.
abstract: Skin irritation is mostly a multifactorial process. Competitive effects of different chemical irritants are well known. This study investigates the influence of a thermal stimulus on skin pre-irritated with sodium lauryl sulfate (SLS). Seventy-seven volunteers were patch-tested with SLS 0.25% and 0.5% for 48 h. Water served as control. Skin reaction was evaluated by measurement of transepidermal water loss, skin blood flow and skin color. After measurement, a thermal stimulus was applied on the test area. The increase in skin blood flow was measured. There was a significant correlation between the degree of irritation and the increase in skin blood flow after thermal stimulus. Pre-irritated skin reacted to thermal stimulus with a shorter and sharper increase in skin blood flow. This increase was dependent on the SLS concentration. Hence, the thermally stimulated blood flow may be a model of non-chemical irritation and seems to be a relevant co-factor in the pathogenesis of irritant dermatitis.
authors.affiliation: Department of Dermatology, Philipp-University of Marburg, Germany. Harald.Loeffler@mailer.uni-marburg.de
authors.forename: H
authors.initials: H
authors.lastname: Löffler
authors.forename: J
authors.initials: J
authors.lastname: Aramaki
authors.forename: I
authors.initials: I
authors.lastname: Effendy
mesh_terms: D000293:Adolescent; D000328:Adult; D003124:Colorimetry; D017453:Dermatitis, Irritant / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006358:Hot Temperature; D006801:Humans; D007509:Irritants; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D010812:Physical Stimulation; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects*; D014870:Water Loss, Insensible
chemical_list: D007509:Irritants; D012967:Sodium Dodecyl Sulfate