title: Combined Analysis of CSF Tau Levels and [(123)I]Iodoamphetamine SPECT in Mild Cognitive Impairment: Implications for a Novel Predictor of Alzheimer's Disease.
abstract: OBJECTIVE
  The aim of this study was to establish an objective and reliable index to predict the development of Alzheimer's disease in a large pool of elderly patients with mild cognitive impairment.
  
  
  METHODS
  Twenty-three patients with probable Alzheimer's disease, 22 patients with mild cognitive impairment who eventually developed Alzheimer's disease, eight patients with mild cognitive impairment who did not develop dementia, and 19 cognitively normal subjects were included in the study. The authors constructed a new diagnostic index, the CSF-CBF index, based on CSF tau levels divided by regional cerebral blood flow (CBF) in the posterior cingulate cortex.
  
  
  RESULTS
  Receiver operating characteristic analysis showed that applying a cutoff value for the CSF-CBF index of 296.0 achieved a sensitivity of 88.5% and a specificity of 90.0% in discriminating mild cognitive impairment that progressed to Alzheimer's disease from mild cognitive impairment that did not progress to Alzheimer's disease.
  
  
  CONCLUSIONS
  The CSF-CBF index is useful in predicting Alzheimer's disease in subjects with mild cognitive impairment.
authors.affiliation: Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Okamura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai
authors.forename: Masahiro
authors.initials: M
authors.lastname: Maruyama
authors.forename: Makoto
authors.initials: M
authors.lastname: Higuchi
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Matsui
authors.forename: Haruko
authors.initials: H
authors.lastname: Tanji
authors.forename: Takashi
authors.initials: T
authors.lastname: Seki
authors.forename: Hisao
authors.initials: H
authors.lastname: Hirai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Chiba
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Itoh
authors.forename: Hidetada
authors.initials: H
authors.lastname: Sasaki
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003072:Cognition Disorders / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D006179:Gyrus Cinguli / Q000098:blood supply; D006801:Humans; D020367:Iofetamine; D008297:Male; D018579:Patient Selection; D010865:Pilot Projects; D011336:Probability; D011379:Prognosis; D012372:ROC Curve; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D015899:Tomography, Emission-Computed, Single-Photon / Q000706:statistics & numerical data*; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D019275:Radiopharmaceuticals; D016875:tau Proteins; D020367:Iofetamine