title: Contraceptive implants and lactation.
abstract: The safety and efficacy of four contraceptive implants, plant, Implanon, Nestorone and Elcometrine, have been evaluated during use in the postpartum period by lactating women. These implants provide highly effective contraceptive protection with no negative effect on breastfeeding or infant growth and development. Breastfeeding women initiating Norplant use in the second postpartum month experience significantly longer periods of amenorrhea than do untreated women or intrauterine device users. After weaning, the bleeding pattern is similar to that observed in non-nursing women. Norplant use does not affect bone turnover and density during lactation. Norplant and Implanon release orally active progestins while Nestorone and Elcometrine implants release an orally inactive progestin, which represents an advantage since the infant should be free of steroidal effects. The infant's daily intake of steroids (estimated from concentrations in maternal milk during the first month of use) range from 90 to 100 ng of levonorgestrel (Norplant), 75-120 ng of etonogestrel (Implanon), and 50 ng and 110 ng of Nestorone (Nestorone and Elcometrine implants, respectively). Nursing women needing contraception may use progestin-only implants when nonhormonal methods are not available or acceptable. Implants that deliver orally active steroids should only be used after 6 weeks postpartum to avoid transferring of steroids to the newborn.
authors.affiliation: Instituto Chileno de Medicina Reproductiva, Santiago, Chile. sdiazm@terra.cl
authors.forename: Soledad
authors.initials: S
authors.lastname: Díaz
mesh_terms: D015519:Bone Density / Q000187:drug effects; D002648:Child; D002657:Child Development / Q000187:drug effects* / Q000502:physiology; D003271:Contraceptive Agents, Female / Q000009:adverse effects* / Q000627:therapeutic use*; D004343:Drug Implants; D005260:Female; D006304:Health Status; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007774:Lactation / Q000187:drug effects* / Q000502:physiology; D008598:Menstruation / Q000187:drug effects*; D008895:Milk, Human / Q000737:chemistry; D009035:Mothers; D049590:Postpartum Period / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D003271:Contraceptive Agents, Female; D004343:Drug Implants