title: Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON).
abstract: Antipruritic effects of 70% ethanol extract (CM-ext) of Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri CUSSON, Umberifferae) were investigated. In mice, an oral administration of CM-ext (200 and 500 mg/kg) inhibited compound 48/80-induced scratching behavior without influence on spontaneous locomotion. Isopimpinellin (3) and osthol (1), coumarin derivatives isolated from CM-ext, showed an inhibitory effect on compound 48/80-induced scratching behavior.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Osaka, Japan. kubo@phar.kindai.ac.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Matsuda
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Ido
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirata
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ino
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Naruto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Amamiya
authors.forename: Michinori
authors.initials: M
authors.lastname: Kubo
mesh_terms: D000818:Animals; D000982:Antipruritics / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology; D005638:Fruit; D006636:Histamine Release / Q000187:drug effects; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D000982:Antipruritics; D003374:Coumarins; D010936:Plant Extracts; D003189:p-Methoxy-N-methylphenethylamine