[Preventive effects of three kinds of inactive vaccines against epidemic hemorrhagic fever (EHF) after 5 years of vaccination].
OBJECTIVE
To observe the safety and the preventive effects of three kinds of vaccines as Mongolian gerbils kidney vaccine, mouse brains vaccine and hamster kidney vaccine inoculated 5 years ago.


METHODS
Field study and laboratory tests were carried out by random grouping and IFAT, MCPENT, ELISA, HI tests.


RESULTS
The antibody-dependent enhancement did not appear in all individuals who received vaccines after four or five years. The seroconversion rates of MCPENT were 8.97%, 11.76% and 18.75% while the seroconversion rates of IFAT were 20.73%, 30.22% and 23.40% respectively for Mongolian gerbils kidney vaccine, mouse brains vaccine and hamster kidney vaccine. The protection rates were 100% for all three kinds of inactive vaccines which showed good epidemiological efficacy.


CONCLUSIONS
The vaccines can protect clinical infection of EHF effectively after four or five years of the initial vaccination.
Chen
H
H
Institute of Epidemiology and Microbiology, Chinese Academy of Preventive Medicine, Beijing 102206, China.
Tang
L
L
Luo
Z
Z
Zhang
J
J
Zhang
Z
Z
Hu
M
M
Weng
J
J
Liu
W
W
Zhao
T
T
Liu
W
W
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D006224:Cricetinae; D005849:Gerbillinae; D018063:Hantaan virus / Q000276:immunology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000517:prevention & control*; D006801:Humans; D051379:Mice; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines