title: Synaptic plasticity in an altered state.
abstract: In this issue of Neuron, record from synaptically coupled pairs of CA3 neurons to closely examine the induction of synaptic depression at a small number of identified synapses. The authors provide convincing evidence that the activation history of a synapse determines both the ability of a synapse to depress and the mechanism of depression.
authors.affiliation: Howard Hughes Medical Institute, Department of Neuroscience, Brown University, Box 1953, Providence, RI 02912, USA.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Philpot
authors.forename: Mark F
authors.initials: MF
authors.lastname: Bear
mesh_terms: D000818:Animals; D004594:Electrophysiology; D006624:Hippocampus / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D066298:In Vitro Techniques; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D018091:Receptors, AMPA / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism / Q000502:physiology*
chemical_list: D018091:Receptors, AMPA; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate