title: Computerized diagnosis of breast lesions on ultrasound.
abstract: We present a computer-aided diagnosis (CAD) method for breast lesions on ultrasound that is based on the automatic segmentation of lesions and the automatic extraction of four features related to the lesion shape, margin, texture, and posterior acoustic behavior. Using a database of 400 cases (94 malignant lesions, 124 complex cysts, and 182 benign solid lesions), we investigate the marginal benefit of each feature in our CAD method and the performance of our CAD method in distinguishing malignant lesions from various classes of benign lesions. Finally, independent validation is performed on our CAD method. Eleven independent trials yielded an average Az value of 0.87 in the task of distinguishing malignant from benign lesions.
authors.affiliation: Department of Radiology, University of Chicago, Illinois 60637, USA.
authors.forename: Karla
authors.initials: K
authors.lastname: Horsch
authors.forename: Maryellen L
authors.initials: ML
authors.lastname: Giger
authors.forename: Luz A
authors.initials: LA
authors.lastname: Venta
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Vyborny
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D002277:Carcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging; D019992:Databases as Topic; D003936:Diagnosis, Computer-Assisted; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015233:Models, Statistical; D012372:ROC Curve; D012984:Software; D014463:Ultrasonography