Bacterial genomics: the use of DNA microarrays and bacterial artificial chromosomes.
Immense amounts of genetic information are contained within microbial genomes. As the number of completely sequenced microbial genomes is increasing, functional and comparative genomic techniques will be employed for sequence analysis and gene characterization. Sequence comparison and expression profiling by DNA microarrays can determine phylogenetic relationships and identify genes while bacterial artificial chromosomes (BACs) allow the study of entire biochemical pathways and permit the expression of bacterial genes in a foreign host.
Ball
Kristen D
KD
Department of Environmental Biology, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
Trevors
J T
JT
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D022202:Chromosomes, Artificial, Bacterial / Q000235:genetics*; D015195:Drug Design; D020869:Gene Expression Profiling; D005798:Genes, Bacterial; D023281:Genomics; D020411:Oligonucleotide Array Sequence Analysis; D010802:Phylogeny; D017421:Sequence Analysis
D000900:Anti-Bacterial Agents