Synthesis and vasorelaxant activity of new coumarin and furocoumarin derivatives.
We have synthesized a new series of coumarins and furocoumarins and evaluated their vasorelaxant activity in rat aorta rings pre-contracted with noradrenaline or by depolarisation with high KCl. The new furocoumarins relax smooth vascular muscle with a profile similar to that of khellin (a furochromone that directly relaxes smooth muscle) and at a greater potency, suggesting that these compounds have a potential interest for the development of new and more efficient vasodilator drugs.
Campos-Toimil
Manuel
M
Departamento de Farmacoloxía, Facultade de Farmacia, Universidade de Santiago de Compostela, Campus Universitario Sur, 15782 Santiago de Compostela, Galicia, Spain. mctoimil@usc.es
Orallo
Francisco
F
Santana
Lourdes
L
Uriarte
Eugenio
E
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001011:Aorta / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D066298:In Vitro Techniques; D007666:Khellin / Q000494:pharmacology; D007700:Kinetics; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000378:metabolism; D051381:Rats; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology*
D000959:Antihypertensive Agents; D003374:Coumarins; D014665:Vasodilator Agents; D007666:Khellin; D011189:Potassium Chloride; D009638:Norepinephrine