title: Guidelines for evaluation of patients at risk for inherited breast and ovarian cancer: recommendations of the Department of Defense Familial Breast/Ovarian Cancer Research Project.
abstract: Patients at high risk for inherited breast and/or ovarian cancer are frequently encountered in all medical specialties. Department of Defense, Health Affairs funding as part of the Breast Cancer Education and Awareness Program was used to develop a comprehensive program for the identification, counseling, genetic testing, and long-term follow-up of such high-risk patients. This article reports the recommendations for high-risk patient management based on 4 years of evaluation and care, including discussions of the approach to counseling, indications for genetic testing, post-testing counseling, patient surveillance with examination, imagining, and laboratory testing, and suggested options for surgical and chemoprophylaxis as well as lifestyle modifications.
authors.affiliation: Air Force Medical Genetics Center, Keesler Air Force Base, MS 39534, USA.
authors.forename: Melissa H
authors.initials: MH
authors.lastname: Fries
authors.forename: Charlene
authors.initials: C
authors.lastname: Holt
authors.forename: Isabelle
authors.initials: I
authors.lastname: Carpenter
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Carter
authors.forename: Jamelyn
authors.initials: J
authors.lastname: Daniels
authors.forename: Judith
authors.initials: J
authors.lastname: Flanagan
authors.forename: Kay
authors.initials: K
authors.lastname: Murphy
authors.forename: B Jo
authors.initials: BJ
authors.lastname: Hailey
authors.forename: Laura
authors.initials: L
authors.lastname: Martin
authors.forename: Roderick
authors.initials: R
authors.lastname: Hume
authors.forename: Gracia
authors.initials: G
authors.lastname: Hudson
authors.forename: Mary
authors.initials: M
authors.lastname: Cadman
authors.forename: Ronald
authors.initials: R
authors.lastname: Weatherly
authors.forename: Mark E
authors.initials: ME
authors.lastname: Nunes
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control*; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005820:Genetic Testing; D017408:Guidelines as Topic; D006801:Humans; D008408:Mastectomy / Q000379:methods; D010051:Ovarian Neoplasms / Q000235:genetics / Q000517:prevention & control*; D010375:Pedigree; D017410:Practice Guidelines as Topic / Q000592:standards*; D013629:Tamoxifen / Q000008:administration & dosage
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen