Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors.
The HIV-1 nucleocapsid protein NCp7, which contains two highly conserved zinc fingers, is being used as a novel target for AIDS therapy due to its pivotal role in viral replication and its mutationally intolerant nature. Herein we report a new class of NCp7 inhibitors that possess good antiviral activity with low cellular toxicity.
Goel
Atul
A
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Mazur
Sharlyn J
SJ
Fattah
Rasem J
RJ
Hartman
Tracy L
TL
Turpin
Jim A
JA
Huang
Mingjun
M
Rice
William G
WG
Appella
Ettore
E
Inman
John K
JK
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001549:Benzamides / Q000737:chemistry*; D002213:Capsid / Q000037:antagonists & inhibitors*; D036022:Capsid Proteins; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D015683:Gene Products, gag / Q000037:antagonists & inhibitors*; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009000:Monocytes / Q000187:drug effects; D013329:Structure-Activity Relationship; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D014764:Viral Proteins; D016335:Zinc Fingers; D054301:gag Gene Products, Human Immunodeficiency Virus
D019380:Anti-HIV Agents; D001549:Benzamides; D036022:Capsid Proteins; D015683:Gene Products, gag; C071884:NCP7 protein, Human immunodeficiency virus 1; D013859:Thiocarbamates; D014409:Tumor Necrosis Factor-alpha; D014764:Viral Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus