Differential Effect of PGE(2) on Adult and Neonatal T-Cell Dependent Immunoglobulin Secretion.
Prostaglandin E(2) (PGE(2)) and other cAMP elevating agents inhibited neonatal but not adult T cell dependent Ig production. PGE(2) did not inhibit IL-2-dependent anti-CD3 stimulated neonatal T cell proliferation or T cell-dependent neonatal B cell proliferation. The results could not be explained by differences in the effect of PGE(2) on cAMP production by neonatal and adult B and T cells or by a unique sensitivity of CD5+ B cells to inhibition by PGE(2). The enhanced sensitivity of neonatal T cell dependent Ig production to inhibition by PGE(2) may play a role in the increased susceptibility of neonatal B and T cells to tolerance induction.
Splawski
Judy B.
JB
Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9063, USA.