title: [Structure and function of eukaryotic nuclear DNA-dependent RNA polymerase I].
abstract: In the eukaryotic cell, normal protein biosynthesis is sustained by several million ribosomes, which contain rRNA as an essential component. The high-molecular-weight precursor of large and 5.8S rRNAs is synthesized by DNA-dependent RNA polymerase I (Pol I) in the nucleolus. Data on DNA regulatory elements, protein factors involved in rDNA transcription by Pol I, subunit composition of Pol I, and on the interactions and possible functions of individual subunits are summarized.
authors.affiliation: Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997 Russia.
authors.forename: E K
authors.initials: EK
authors.lastname: Shematorova
authors.forename: G V
authors.initials: GV
authors.lastname: Shpakovskiĭ
mesh_terms: D000818:Animals; D003001:Cloning, Molecular; D021901:DNA, Intergenic; D004742:Enhancer Elements, Genetic; D005057:Eukaryotic Cells / Q000201:enzymology*; D006801:Humans; D011401:Promoter Regions, Genetic; D021122:Protein Subunits; D012318:RNA Polymerase I / Q000737:chemistry* / Q000502:physiology*; D012335:RNA, Ribosomal / Q000096:biosynthesis*; D014158:Transcription, Genetic; D015032:Zinc / Q000378:metabolism
chemical_list: D021901:DNA, Intergenic; D021122:Protein Subunits; D012335:RNA, Ribosomal; D012318:RNA Polymerase I; D015032:Zinc