title: Toward high-throughput synthesis of complex natural product-like compounds in the genomics and proteomics age.
abstract: In the age of high-throughput biology, novel genes and proteins are emerging quickly. The need for developing organic synthesis-derived methods that allow rapid access to polyfunctional, complex natural product-like compounds is growing constantly, largely because these small-molecule-based compounds serve as smart, powerful tools both in understanding the roles and functions of emerging biological targets and in validating their biological responses. Developing asymmetric synthesis-derived organic reactions on solid phase allows the synthesis of complex natural product-like compounds in a high-throughput manner. Solid phase organic synthesis is now commonly utilized in the library synthesis of rather simple compounds (i.e., compounds with no multiple stereogenic centers). With few exceptions, the synthesis of complex natural product-like derivatives is still in its infancy. Some recent efforts made in this area indicate opportunities yet to be explored.
authors.affiliation: Chemical Biology Program, Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
authors.forename: Prabhat
authors.initials: P
authors.lastname: Arya
authors.forename: Reni
authors.initials: R
authors.lastname: Joseph
authors.forename: Doug T H
authors.initials: DT
authors.lastname: Chou
mesh_terms: D001685:Biological Factors / Q000138:chemical synthesis* / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D023281:Genomics; D018716:Molecular Mimicry; D019151:Peptide Library; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D011485:Protein Binding; D020543:Proteome; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D001685:Biological Factors; D019151:Peptide Library; D011083:Polycyclic Compounds; D020543:Proteome