title: Management of progressive pain in a patient with intramedullary chordoma of the spine.
abstract: OBJECTIVE
  The case here presented adequately reflects the difficulties involved in the treatment of pain in patients where the neuropathic component of pain predominates, and shows the different therapeutic steps that may be taken-from surgery and radiotherapy, to the administration of different drugs via the spinal route, to, finally, the presently little-used option of a direct intraventricular access.
  
  
  CONCLUSIONS
  Spinal tumors are infrequent, but pose great difficulties for the management and control of the pain they cause. The utility of the spinal route as an early approach for the provision of adequate analgesia seems clear. However, it also appears to lose efficacy with time, and dose incrementing and/or the addition of drugs that enhance the analgesic action of morphine are not always effective. In such selected cases, the intraventricular route may constitute a useful alternative, allowing improved symptoms control with lower morphine doses, and the use of the system previously implanted for intrathecal spinal infusion.
authors.affiliation: Multidisciplinary Pain Management Center, Department of Anesthesia, Valencia University General Hospital, Valencia, Spain. fundolor@gva.es
authors.forename: G
authors.initials: G
authors.lastname: Cerda-Olmedo
authors.forename: J
authors.initials: J
authors.lastname: De Andrés
authors.forename: S
authors.initials: S
authors.lastname: Moliner
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000627:therapeutic use; D002045:Bupivacaine / Q000008:administration & dosage*; D002408:Catheters, Indwelling; D002817:Chordoma / Q000150:complications*; D003000:Clonidine / Q000008:administration & dosage; D018450:Disease Progression; D006801:Humans; D007278:Injections, Spinal / Q000379:methods; D008161:Lumbosacral Region / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage*; D010148:Intractable Pain / Q000188:drug therapy* / Q000209:etiology; D013120:Spinal Cord Neoplasms / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery
chemical_list: D000700:Analgesics; D000779:Anesthetics, Local; D009020:Morphine; D003000:Clonidine; D002045:Bupivacaine