title: Bifonazole modulates death of cultured cerebellar granular cells induced by glutamate and oxygen-glucose deprivation.
abstract: Treatment of cultured rat cerebellar granular cells with calmodulin antagonist bifonazole (10 mM) during oxygen-glucose deprivation or exposure to glutamate (75 mM) prevented neuronal death. However, addition of bifonazole after glutamate treatment promoted neuronal death. Calmodulin antagonists trifluoperazine and thioridazine had no protective effects, while thioridazine even potentiated the toxic effect of glutamate.
authors.affiliation: Institute of Brain Research, Russian Academy of Medical Sciences. stelmash@ cc.nifhi.ac.ru
authors.forename: E V
authors.initials: EV
authors.lastname: Stel'mashuk
authors.forename: N A
authors.initials: NA
authors.lastname: Andreeva
authors.forename: L
authors.initials: L
authors.lastname: Manukhova
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
authors.forename: N K
authors.initials: NK
authors.lastname: Isaev
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002147:Calmodulin / Q000037:antagonists & inhibitors; D016923:Cell Death; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology*; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism*; D007093:Imidazoles / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013881:Thioridazine / Q000494:pharmacology; D013997:Time Factors; D014268:Trifluoperazine / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D002147:Calmodulin; D018492:Dopamine Antagonists; D005971:Glutamates; D007093:Imidazoles; D014268:Trifluoperazine; D018698:Glutamic Acid; D005947:Glucose; D013881:Thioridazine; C036596:bifonazole; D010100:Oxygen; D002118:Calcium