Colorectal cancer risk: the impact of evidence of a field effect of carcinogenesis on blinded diagnosis using an anti-adenoma antibody test performed on colonoscopic effluent.
To better define high-risk populations for colorectal cancer screening, we used anti-adenoma antibody Adnab-9, comparing colonic effluent and tissue field effects from 45 high-risk and 11 control patients. We included Adnab-9 binding at the tissue level to elucidate the impact of a field effect of carcinogenesis contributing to the outcome of the effluent binding test. In high-risk patients, 64% of the left-sided effluent samples were positive (P < 0.002); 67% showed a field effect (P < 0.006); 82% of combined tests were positive (P < 0.001), as compared to 9%, 18%, and 27% respectively, of controls. Adnab-9 binding correlates with increased colorectal cancer risk associated with a field effect of carcinogenesis.
Tobi
Martin
M
Department of Medicine, John D. Dingell VAMC, Detroit, Michigan 48201, USA.
Prabhu
Shivkumar
S
Gage
Rhonda E
RE
Orr
Tashia
T
Lawson
Michael J
MJ
D000236:Adenoma / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D016022:Case-Control Studies; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D018570:Risk Assessment; D007507:Therapeutic Irrigation
D000911:Antibodies, Monoclonal