title: Constituents of the leaves and twigs of Ficus hispida.
abstract: A new norisoprenoid, ficustriol (1), and the known phenanthroindolizidine alkaloid O-methyltylophorinidine (2), were isolated from a CHCl3 extract of the leaves and twigs of Ficus hispida. O-Methyltylophorinidine showed potent cytotoxic activity when tested against a small panel of human cancer cells, while ficustriol was inactive. The structure and stereochemistry of 1 were determined using chemical and spectral methods.
authors.forename: Sergio R
authors.initials: SR
authors.lastname: Peraza-Sánchez
authors.forename: Hee-Byung
authors.initials: HB
authors.lastname: Chai
authors.forename: Young Geun
authors.initials: YG
authors.lastname: Shin
authors.forename: Thawatchai
authors.initials: T
authors.lastname: Santisuk
authors.forename: Vichai
authors.initials: V
authors.lastname: Reutrakul
authors.forename: Norman R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Cordell
authors.forename: John M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D030681:Ficus; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013785:Thailand; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D026121:Indole Alkaloids; C455126:O-methyltylophorinidine; D010616:Phenanthrenes; D010936:Plant Extracts; D013729:Terpenes; C455127:ficustriol