Unique TCR beta-subunit variable gene haplotypes in Africans.
This study investigated polymorphisms of genes in two regions of the T-cell antigen receptor beta-subunit (TCRB) locus, including BV9S2P, and BV6S7 in a 5' linkage group, and BV8S3, BV24S1, BV25S1, BV18S1, BV2S1, BV15S1 and BV3S1 in a 3' linkage group. These loci have been genotyped in individuals from five regions in Africa, including The Gambia, Nigeria, Cameroon, Tanzania, and Zambia, and in individuals from northern Britain, northern India, and Papua New Guinea (PNG). In the 3' linkage group, 11 unique haplotypes were identified in the combined African populations; two equally frequent haplotypes represent the majority of African chromosomes. One haplotype was found in all four regions studied. This is the most frequent haplotype in the northern British, northern Indian and PNG populations. Although present, it is infrequent in the African populations. A North-South gradient in the frequency of a common African haplotype was observed. The distribution did not represent that of a known disease. Evidence suggests that malaria is not responsible for selection of these haplotypes. Overall, this study highlights large differences in the genetic constitution of the TCRB locus between Africans and other populations.
Donaldson
Ian J
IJ
Molecular Medicine Unit, Level 6, Clinical Sciences Building, St. James's University Hospital, Leeds, LS9 7TF, UK.
Shefta
Jahan
J
Lawson
Cathy A
CA
Bushnell
James R
JR
Morgan
Ann W
AW
Isaacs
John D
JD
Carpenter
Danielle
D
Shaw
Marie-Anne
MA
Rooth
Ingegerd
I
Quinnell
Rupert J
RJ
Zumla
Alimuddin M
AM
Ollier
William R
WR
Chintu
Chifumbe Z
CZ
Muyinda
Gabriel P
GP
Hill
Adrian S
AS
Boylston
Arthur W
AW
D000349:Africa; D044383:Black People / Q000235:genetics*; D022801:Complementarity Determining Regions / Q000235:genetics*; D005787:Gene Frequency; D019674:Genes, T-Cell Receptor beta / Q000235:genetics*; D005843:Geography; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007194:India; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D021122:Protein Subunits; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology; D006113:United Kingdom; D044465:White People / Q000235:genetics
D022801:Complementarity Determining Regions; D021122:Protein Subunits; D016693:Receptors, Antigen, T-Cell, alpha-beta