title: Analysis of IL-18 bioactivity and IL-18 mRNA in three patients with adult T-cell leukaemia, acute mixed lineage leukaemia, and acute lymphocytic leukaemia accompanied with high serum IL-18 levels.
abstract: Interleukin-18 (IL-18) bioactivity in sera and IL-18 mRNA expression in leukaemia cells of three patients with adult T-cell leukaemia (ATL), acute mixed lineage leukaemia (AMLL) and acute lymphocytic leukaemia (ALL) accompanied with high serum IL-18 levels have been analysed. There was little serum IL-18 bioactivity in the three patients with ATL, AMLL and ALL, while IL-18 mRNA expression was detected in leukaemia cells of all three patients.
authors.affiliation: Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University, Japan. m3542254@med.osaka-cu.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Takubo
authors.forename: T
authors.initials: T
authors.lastname: Kumura
authors.forename: H
authors.initials: H
authors.lastname: Kanashima
authors.forename: T
authors.initials: T
authors.lastname: Nakao
authors.forename: H
authors.initials: H
authors.lastname: Nakamae
authors.forename: Y
authors.initials: Y
authors.lastname: Aoyama
authors.forename: R
authors.initials: R
authors.lastname: Yamamura
authors.forename: T
authors.initials: T
authors.lastname: Ohta
authors.forename: K R
authors.initials: KR
authors.lastname: Koh
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: T
authors.initials: T
authors.lastname: Yamane
authors.forename: M
authors.initials: M
authors.lastname: Hino
authors.forename: T
authors.initials: T
authors.lastname: Kamitani
authors.forename: N
authors.initials: N
authors.lastname: Tatsumi
mesh_terms: D000208:Acute Disease; D000368:Aged; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis / Q000187:drug effects; D020382:Interleukin-18 / Q000097:blood / Q000235:genetics / Q000502:physiology*; D007938:Leukemia / Q000097:blood* / Q000378:metabolism; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D020382:Interleukin-18; D012333:RNA, Messenger; D007371:Interferon-gamma