title: [Vaccination of children under immunosuppressive therapy with ADS-m anatoxin ].
abstract: The effectiveness and safety of the immunization of children with adsorbed DT toxoid with reduced component with disturbances in the reactivity of the body, caused by immunosuppressive therapy, are evaluated. The group under study included 53 children with glomerulonephritis, malignant tumors and acute lymphoblast leucosis, formerly receiving immunosuppressive drugs. The control group consisted of 24 patients with pyelonephritis who had not received such therapy. In the postvaccinal period no exacerbation of the main disease was registered in children. The manifestation and frequence of postvaccinal reactions did not differ from those observed in healthy children after the injection of adsorbed DT toxoid with reduced antigen content. Control serological testing demonstrated the presence of pronounced immune response in the vaccinees.
authors.affiliation: Mechnikov Research Institute for Vaccines and Sera, Research Center of Child Oncology and Hematology, Research Institute of Child Hematology, Research Center of Child Health, Moscow, Russia.
authors.forename: O O
authors.initials: OO
authors.lastname: Magarshak
authors.forename: M P
authors.initials: MP
authors.lastname: Kostinov
authors.forename: S V
authors.initials: SV
authors.lastname: Karpocheva
authors.forename: V A
authors.initials: VA
authors.lastname: Verbniak
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004165:Diphtheria / Q000276:immunology / Q000517:prevention & control*; D022422:Diphtheria-Tetanus Vaccine / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D007165:Immunosuppression Therapy; D013742:Tetanus / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination; D017778:Vaccines, Combined
chemical_list: D022422:Diphtheria-Tetanus Vaccine; D017778:Vaccines, Combined