[Serum leptin levels in the perioperative period in surgery patients].
OBJECTIVE
To assess dynamics of serum leptin concentrations (as a possible marker of stress) at some surgical patients during short perioperative period.


METHODS
The serum leptin concentrations were estimated in group of patients with trauma or large bowel diseases in stress of both own disease and next elective or urgent surgery. The subgroups of patients were: a) monotrauma (13), b) polytrauma (10), c) malignant (20) or d) inflammatory disease (13) of large bowel. The serum leptin concentrations were evaluated preoperatively and during 16 hours postoperatively-immediately after surgery, after 8 and 16 hours after operation. The serum IL-6 concentrations were estimated immediately and 48 hours postoperatively.


RESULTS
The serum leptin concentrations showed a time depending dynamic phase: they decreased postoperatively and increased during the first 16 hours postoperatively. It was more expressed in the malignant bowel disease subgroup. A correlation between age and serum leptin concentrations was not found in any subgroup. We found correlation between serum leptin concentrations preoperatively and postoperatively.


CONCLUSIONS
The serum leptin concentrations demonstrated some dynamics in short perioperative periods. It was very considerably in patients with large bowel malignancy. Any significant difference in serum IL-6 concentrations was not discovered preoperatively and postoperatively in all subgroups.
Kaska
M
M
Chirurgická klinika, Lékarská fakulta UK a Fakultní nemocnice v Hradci Králové.
Zivný
P
P
D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007410:Intestinal Diseases / Q000601:surgery; D020738:Leptin / Q000097:blood*; D013312:Stress, Physiological / Q000097:blood* / Q000209:etiology; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D014947:Wounds and Injuries / Q000601:surgery
D015850:Interleukin-6; D020738:Leptin