title: Dynamic ventilation (3)He-magnetic resonance imaging with lung motion correction: gas flow distribution analysis.
abstract: OBJECTIVE
  Software was developed to correct for lung motion to improve the description of hyperpolarized (3)He gas distribution in the lung.
  
  
  METHODS
  Five volunteers were studied by dynamic ventilation (3)He-MRI using an ultrafast FLASH 2D sequence with a temporal resolution of 128 milliseconds. Signal kinetics were evaluated in the trachea and seven parenchymal Regions of Interest. Reference ranges for healthy subjects were defined for motion-corrected and uncorrected images.
  
  
  RESULTS
  Motion correction was successfully performed. Reference ranges were 0.11-1.21 seconds for tracheal transit time, 0-0.02 seconds for trachea-alveolar interval, 0.22-0.62 seconds for alveolar rise time and 0-76.6 arbitrary units for alveolar amplitude for motion corrected images, and 0-1.09 seconds, 0-0.11 seconds, 0.26-0.85 seconds, 46.4-99.8 arbitrary units for uncorrected images.
  
  
  CONCLUSIONS
  Evaluation of (3)He-distribution in the lung using motion correction of dynamic (3)He-ventilation imaging is feasible and gives more narrow reference ranges.
authors.affiliation: Department of Radiology, Klinikum Universitaet Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany. kgast@radiologie.klinik.uni-mainz.de
authors.forename: Klaus Kurt
authors.initials: KK
authors.lastname: Gast
authors.forename: Michael Ulrich
authors.initials: MU
authors.lastname: Puderbach
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rodriguez
authors.forename: Balthasar
authors.initials: B
authors.lastname: Eberle
authors.forename: Klaus
authors.initials: K
authors.lastname: Markstaller
authors.forename: Alexander Thomas
authors.initials: AT
authors.lastname: Hanke
authors.forename: Joerg
authors.initials: J
authors.lastname: Schmiedeskamp
authors.forename: Norbert
authors.initials: N
authors.lastname: Weiler
authors.forename: Jana
authors.initials: J
authors.lastname: Lill
authors.forename: Wolfgang G
authors.initials: WG
authors.lastname: Schreiber
authors.forename: Manfred
authors.initials: M
authors.lastname: Thelen
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
mesh_terms: D000328:Adult; D005260:Female; D006371:Helium; D006801:Humans; D007554:Isotopes; D008168:Lung / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D012123:Pulmonary Ventilation / Q000502:physiology*; D015656:Respiratory Mechanics; D012984:Software; D013997:Time Factors
chemical_list: D007554:Isotopes; D006371:Helium