Discordance between T-cell receptor expression and effector function in mice infected with Histoplasma capsulatum.
V beta 10(+) and V beta 14(+) T cells were selectively increased 7 to 14 days following infection in the lungs of naive mice infected with Histoplasma capsulatum. Following secondary challenge of immune mice, V beta 1(+) and V beta 8.1(+) cells were sporadically increased. Elimination of V beta 10(+) and V beta 14(+) cells from naive mice did not alter the course of infection over a period of 21 days. Thus, overexpression of V beta families does not necessarily signify a key role in host defense.
Deepe
George S
GS
Veterans Affairs Hospital and Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0560, USA. george.deepe@uc.edu
Gibbons
Reta S
RS
Ward
Susan R
SR
D000818:Animals; D019674:Genes, T-Cell Receptor beta / Q000276:immunology*; D006660:Histoplasmosis / Q000276:immunology*; D008172:Lung Diseases, Fungal / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D013154:Spleen / Q000276:immunology
D016693:Receptors, Antigen, T-Cell, alpha-beta