title: Tandem application of sodium lauryl sulfate and n-propanol does not lead to enhancement of cumulative skin irritation.
abstract: Irritant contact dermatitis has a broad spectrum of clinical features and is a leading cause of occupational disease worldwide. It has been shown previously that a combination of chemically different irritants may cause an additive effect compared to single application of these substances. In this study, tandem application of sodium lauryl sulfate and n-propanol was investigated in 20 human volunteers using non-invasive bioengineering methods, such as measurement of transepidermal water loss and chromametry. N-propanol did not enhance cumulative skin irritation when used with sodium lauryl sulfate, as has been reported for toluene. As n-propanol is the active ingredient in many disinfectants, this is of particular interest regarding occupational skin irritation in health care workers.
authors.affiliation: Department of Dermatology, Friedrich-Schiller-University, Jena, Germany. kappes@derma.uni-jena.de
authors.forename: U P
authors.initials: UP
authors.lastname: Kappes
authors.forename: N
authors.initials: N
authors.lastname: Göritz
authors.forename: W
authors.initials: W
authors.lastname: Wigger-Alberti
authors.forename: C
authors.initials: C
authors.lastname: Heinemann
authors.forename: P
authors.initials: P
authors.lastname: Elsner
mesh_terms: D000433:1-Propanol / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D003124:Colorimetry; D017453:Dermatitis, Irritant / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D009783:Dermatitis, Occupational / Q000209:etiology / Q000473:pathology; D004890:Erythema / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006801:Humans; D007509:Irritants / Q000008:administration & dosage*; D008297:Male; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000009:adverse effects*; D014870:Water Loss, Insensible
chemical_list: D007509:Irritants; D012967:Sodium Dodecyl Sulfate; D000433:1-Propanol