Cytotoxic-antineoplastic activity of hydroquinone derivatives.
Several myrcenylhydroquinone derivatives have been evaluated for their cytotoxic activity against three neoplastic cell line cultures and compared with the activity previously observed on other neoplastic systems. Also a new series of this type of compounds has been prepared and the compounds synthesised have been evaluated by their GI(50) values.
Molinari
Aurora
A
Instituto de Química, Universidad Católica de Valparaíso, Casilla 4059, Valparaíso, Chile. amolinar@ucv.cl
Oliva
Alfonso
A
Reinoso
Paola
P
del Corral
Jose M  Miguel
JM
Castro
M Angeles
MA
Gordaliza
Marina
M
Gupta
Mahabir P
MP
Solís
Pablo
P
San Feliciano
Arturo
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006873:Hydroquinones