title: The effects of several vasopressin receptor antagonists on normal intraocular pressure and the intraocular distribution of vasopressin receptor subtypes.
abstract: The aim of the present paper is to study the relation between vasopressin antagonism and the regulation of intraocular pressure (IOP). From the studies on the effect of several vasopressin receptor antagonists, VP-343, OPC-21268, YM087, OPC-31260 and SR121463, on normal IOP and the effect of VP-343 on pupil diameter in rabbit, it was shown that some vasopressin antagonists decreased normal IOP and VP-343 had no influence on pupil diameter. A vasopressin receptor mapping study in normal cynomolgus monkey eye revealed a high density binding site for a [H3]vasopressin V1 antagonist in the region of iris. These findings suggest that a vasopressin antagonist should decrease normal IOP without miosis and that vasopressin V1 receptors are present in iris.
authors.affiliation: Sagami Research Laboratory, Wakamoto Pharmaceutical Co., Ltd., Ashigarakamigun, Kanagawa, Japan. a-naito@wakamoto-pharm.co.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Naito
authors.forename: Takashi
authors.initials: T
authors.lastname: Kurasawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ohtake
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Toyoda
authors.forename: Yohji
authors.initials: Y
authors.lastname: Ezure
authors.forename: Katsuo
authors.initials: K
authors.lastname: Koike
authors.forename: Koki
authors.initials: K
authors.lastname: Shigenobu
mesh_terms: D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D005123:Eye / Q000737:chemistry*; D007429:Intraocular Pressure / Q000187:drug effects*; D008252:Macaca fascicularis; D008297:Male; D011817:Rabbits; D017483:Receptors, Vasopressin / Q000145:classification
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D017483:Receptors, Vasopressin