title: Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation.
abstract: Gastrol (1), together with 10 known phenolic compounds, has been isolated from the MeOH extract of the rhizomes of Gastrodia elata Blume (Orchidaceae), and their structures were elucidated by detailed spectral analyses including by 2D NMR spectroscopic analyses. The relaxant effects of these constituents on smooth muscle preparations isolated from guinea-pig ileum were also studied in order to reveal their characteristic pharmacological activities.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, 263-8522, Chiba, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Hayashi
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Sekine
authors.forename: Shigeyoshi
authors.initials: S
authors.lastname: Deguchi
authors.forename: Qing
authors.initials: Q
authors.lastname: Lin
authors.forename: Syunji
authors.initials: S
authors.lastname: Horie
authors.forename: Shizuko
authors.initials: S
authors.lastname: Tsuchiya
authors.forename: Shingo
authors.initials: S
authors.lastname: Yano
authors.forename: Kazuo
authors.initials: K
authors.lastname: Watanabe
authors.forename: Fumio
authors.initials: F
authors.lastname: Ikegami
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D029595:Orchidaceae / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D010636:Phenols