Commentary on "Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus", by RR Graham et al.
Genome-wide linkage analysis studies in families with systemic lupus erythematosus (SLE) have revealed consistent evidence of linkage to several regions of the genome. In a previous issue of this journal, Graham and colleagues described their approach to following up the linkage data for one of these regions, 1q41-42. Using methods based on the transmission disequilibrium test, the region likely to harbour a SLE disease gene was refined to 2.3 Mb. This commentary discusses their approach and identifies lessons that may be applicable to the investigation of other complex diseases.
Barton
Anne C
AC
Arthritis and Rheumatism Campaign Epidemiology Unit, Stopford Building, University of Manchester M13 9PT, Manchester, UK. ABarton@fs1.ser.man.ac.uk
Worthington
Jane
J
D000818:Animals; D002878:Chromosomes, Human, Pair 1; D004247:DNA / Q000032:analysis; D004195:Disease Models, Animal; D005192:Family Health; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D020161:Physical Chromosome Mapping
D005819:Genetic Markers; D004247:DNA