[Immunocyte reaction in stage III nasopharyngeal carcinoma in relation to biological findings and prognosis].
OBJECTIVE
To study the relationship between macrophages (MP), Langerhans cells (LC), T and B lymphocytes, biological behavior and prognosis of stage III nasopharyngeal carcinoma (NPC) patients.


METHODS
43 cases with stage III NPC were studied by immunohistochemical SP staining methods.


RESULTS
The positive expression rates of infiltrating LC and/or MP in NPC were 41%, 65% (CD68+), 46% (lysozyme+), and were related to prognosis, but not to age, sex, metastasis to cervical lymph nodes and basi-cranial destruction and/or cranial nerve damage. In addition, infiltrating T or B cells in NPC were not related to the prognosis or biological behavior. However, when both infiltrating T lymphocytes and LC and/or MP were marked, the prognosis of these cases were better than that of those cases whose infiltrating LC and/or MP were marked but T cell infiltration was scarce.


CONCLUSIONS
The prognosis of stage III NPC is related to LC or MP, survival is especially longer in those with marked T cell infiltration.
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Department of Pathology, Guiyang Medical College, Guiyang, 550004.
Zhuang
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Zhang
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D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000737:chemistry / Q000276:immunology*; D008207:Lymphatic Metastasis; D016246:Lymphocytes, Tumor-Infiltrating / Q000737:chemistry / Q000276:immunology; D008264:Macrophages / Q000737:chemistry / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis; D009303:Nasopharyngeal Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D009418:S100 Proteins / Q000032:analysis; D016019:Survival Analysis; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009113:Muramidase; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule