title: Higher lipoprotein (a) levels in atherothrombotic than lacunar ischemic cerebrovascular disease.
abstract: To investigate the role of plasma lipid abnormalities in ischemic cerebrovascular disease related to primary vessel disease, the authors assess lipid profiles in a hospital-based cohort of 202 consecutive patients with atherothrombotic or lacunar stroke subtypes. Lipoprotein (a) was the unique lipid parameter that differs between these two subtypes being its value twofold higher in patients with atherothrombotic than in lacunar stroke. This suggests that lipoprotein (a) promotes large vessel atheromatosis rather than small vessel arteriolosclerosis and favors thrombosis on atheromatous plaques by suppressing local fibrinolysis.
authors.affiliation: Department of Neuroscience, University of Turin, Torino, Italy. paolo_cerrato@yahoo.com
authors.forename: P
authors.initials: P
authors.lastname: Cerrato
authors.forename: D
authors.initials: D
authors.lastname: Imperiale
authors.forename: P
authors.initials: P
authors.lastname: Fornengo
authors.forename: G
authors.initials: G
authors.lastname: Bruno
authors.forename: M
authors.initials: M
authors.lastname: Cassader
authors.forename: P
authors.initials: P
authors.lastname: Maffeis
authors.forename: P
authors.initials: P
authors.lastname: Cavallo Perin
authors.forename: G
authors.initials: G
authors.lastname: Pagano
authors.forename: B
authors.initials: B
authors.lastname: Bergamasco
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000097:blood*; D002545:Brain Ischemia / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged
chemical_list: D017270:Lipoprotein(a)