Colorectal cancer in mice genetically deficient in the mucin Muc2.
The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2-/- mice displayed aberrant intestinal crypt morphology and altered cell maturation and migration. Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal cancer.
Velcich
Anna
A
Department of Oncology, Albert Einstein Cancer Center/Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467, USA. velcich@aecom.yu.edu
Yang
WanCai
W
Heyer
Joerg
J
Fragale
Alessandra
A
Nicholas
Courtney
C
Viani
Stephanie
S
Kucherlapati
Raju
R
Lipkin
Martin
M
Yang
Kan
K
Augenlicht
Leonard
L
D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology; D000236:Adenoma / Q000737:chemistry / Q000473:pathology; D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D002455:Cell Division; D019070:Cell Lineage; D002465:Cell Movement; D003106:Colon / Q000737:chemistry / Q000166:cytology / Q000473:pathology; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D003598:Cytoskeletal Proteins / Q000032:analysis; D018450:Disease Progression; D004379:Duodenal Neoplasms / Q000737:chemistry / Q000473:pathology; D004386:Duodenum / Q000737:chemistry / Q000166:cytology / Q000473:pathology; D004847:Epithelial Cells / Q000737:chemistry / Q000502:physiology; D005260:Female; D018390:Gene Targeting; D020397:Goblet Cells / Q000166:cytology; D007413:Intestinal Mucosa / Q000737:chemistry / Q000166:cytology / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D055262:Mucin-2; D009077:Mucins / Q000032:analysis / Q000235:genetics* / Q000502:physiology*; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis; D015534:Trans-Activators; D051176:beta Catenin
C495267:CTNNB1 protein, mouse; D003598:Cytoskeletal Proteins; C524626:Muc2 protein, mouse; D055262:Mucin-2; D009077:Mucins; D016271:Proto-Oncogene Proteins c-myc; D015534:Trans-Activators; D051176:beta Catenin