title: Adjustment of the human respiratory system to increased upper airway resistance during sleep.
abstract: A cardiorespiratory model incorporating control of the human upper airway during sleep is described. Most previous models have not considered the possibility that the upper airway could be a limiting factor for gas exchange. Our model was developed to also predict certain pathophysiological phenomena in the cardiorespiratory system that characterize heavy snoring or sleep apnea. We started by adapting our collapsible upper airway model to include the impact of nasal passage and larynx, and extended the model with equations for gas exchange in the lungs. A feedback loop both to the respiratory pump and the upper airway dilator muscles was included. The model enabled successful breath-by-breath simulations of obstructive events of the upper airway. Although the model incorporates several physiologically relevant components of the system, the simulation results suggest that only few parameters suffice to predict the key adjustments that the cardiorespiratory system is known to make in patients with heavy snoring.
authors.affiliation: Department of Mathematics, University of Turku, 20014 Turku, Finland, Turku Centre for Computer Science (TUCS), Lemminkäisenkatu 14A, 20520 Turku, Finland. tero.aittokallio@utu.fi
authors.forename: T
authors.initials: T
authors.lastname: Aittokallio
authors.forename: M
authors.initials: M
authors.lastname: Gyllenberg
authors.forename: O
authors.initials: O
authors.lastname: Polo
mesh_terms: D000402:Airway Obstruction / Q000503:physiopathology*; D003198:Computer Simulation; D005246:Feedback; D006801:Humans; D008954:Models, Biological; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012137:Respiratory System / Q000503:physiopathology; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*; D012913:Snoring / Q000503:physiopathology