[Acute kidney failure caused by paracetamol poisoning].
Paracetamol poisoning is manifested by hepatotoxicity, but acute renal failure is very rare, especially when there is no fulminant hepatic damage with encephalopathy or severe haemodynamic alterations. We present here the case of a 22-year-old woman who presented with acute renal failure after the ingestion of 11.5 g of acetaminophen. The clinical course and laboratory data were consistent with tubular necrosis. The patient required hemodialysis, but finally renal function returned to normal. The acetaminophen pharmacology and the differential diagnosis of acute azotemia in paracetamol overdosage are reviewed.
Herrero
J L
JL
Sección de Nefrología, Hospital San Pedro de Alcántara, Avda. Millán Astray, s/n. 10003 Cáceres.
Castellano
I
I
Gómez-Martino
J R
JR
Novillo
R
R
Covarsí
A
A
D000082:Acetaminophen / Q000506:poisoning*; D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D000328:Adult; D001780:Blood Coagulation Tests; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007677:Kidney Function Tests; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced*; D008111:Liver Function Tests; D009325:Nausea / Q000139:chemically induced; D006435:Renal Dialysis; D013406:Suicide, Attempted; D014839:Vomiting / Q000139:chemically induced
D000082:Acetaminophen