title: [Neurofibromatosis 1: recommendations for management].
abstract: Twenty experts, members of a French medical network devoted to neurofibromatosis 1 have elaborated recommendations for the management of the disease. Bibliography was obtained through a Medline of articles from 1966 to 1999 for the terms neurofibromatosis, NF1, neurofibroma and from textbooks. A consensual document was written taking into account extracted data. An annual careful clinical examination is recommended except in cases with complications. Screening investigations are not recommended due to the rarity of complications, generally symptomatic and easily detected during the clinical follow-up. The only controversial exception might be magnetic resonance imaging for early detection of optic pathway gliomas in young children. A co-ordinated follow-up in specialised multidisciplinary centres, providing patients with a rational management, is recommended.
authors.affiliation: Hôpital Edouard-Herriot, Lyon, France. pierre.wolkenstein@hmn.ap-hop-paris.fr
authors.forename: S
authors.initials: S
authors.lastname: Pinson
authors.forename: A
authors.initials: A
authors.lastname: Créange
authors.forename: S
authors.initials: S
authors.lastname: Barbarot
authors.forename: J F
authors.initials: JF
authors.lastname: Stalder
authors.forename: Y
authors.initials: Y
authors.lastname: Chaix
authors.forename: D
authors.initials: D
authors.lastname: Rodriguez
authors.forename: M
authors.initials: M
authors.lastname: Sanson
authors.forename: A
authors.initials: A
authors.lastname: Bernheim
authors.forename: M
authors.initials: M
authors.lastname: d'Incan
authors.forename: F
authors.initials: F
authors.lastname: Doz
authors.forename: C
authors.initials: C
authors.lastname: Stoll
authors.forename: P
authors.initials: P
authors.lastname: Combemale
authors.forename: C
authors.initials: C
authors.lastname: Kalifa
authors.forename: J
authors.initials: J
authors.lastname: Zeller
authors.forename: D
authors.initials: D
authors.lastname: Teillac-Hamel
authors.forename: S
authors.initials: S
authors.lastname: Lyonnet
authors.forename: M
authors.initials: M
authors.lastname: Zerah
authors.forename: J P
authors.initials: JP
authors.lastname: Lacour
authors.forename: B
authors.initials: B
authors.lastname: Guillot
authors.forename: P
authors.initials: P
authors.lastname: Wolkenstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D009456:Neurofibromatosis 1 / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D011379:Prognosis; D011859:Radiography; D013997:Time Factors