Synthesis and notable antimalarial activity of acyclic peroxides, L-(alkyldioxy)-L-(methyldioxy)cyclododecanes.
Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).
Hamada
Yoshiaki
Y
Department of Materials Chemistry & Frontier Research Center, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Tokuhara
Hidekazu
H
Masuyama
Araki
A
Nojima
Masatomo
M
Kim
Hye-Sook
HS
Ono
Kanako
K
Ogura
Naoki
N
Wataya
Yusuke
Y
D000473:Alkanes / Q000737:chemistry; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D003516:Cycloparaffins / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D006844:Hydrocarbons, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D016778:Malaria, Falciparum / Q000188:drug therapy; D051379:Mice; D010545:Peroxides / Q000138:chemical synthesis* / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D014407:Tumor Cells, Cultured
C452426:1,2-bis(methyldioxy)cyclododecane; D000473:Alkanes; D000962:Antimalarials; D003516:Cycloparaffins; D006844:Hydrocarbons, Cyclic; D010545:Peroxides; C007548:n-dodecane