Increased antibody production by retinoids is related to the fusion partner of human hybridomas.
An increase of human monoclonal antibody production caused by retinyl acetate and retinoic acid was influenced by the fusion partner rather than the original B lymphocyte used for the human hybridoma generation. Retinoid response of human hybridomas may be at least related to retinoid X receptor-alpha gene expression, which seemed to originate from their fusion partner.
Inoue
Yuichi
Y
Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Japan. inoue@chem.agri.kagoshima-u.ac.jp
Shirahata
Sanetaka
S
D000328:Adult; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D000912:Antibodies, Neoplasm / Q000096:biosynthesis*; D000917:Antibody Formation / Q000187:drug effects; D002459:Cell Fusion; D004224:Diterpenes; D015870:Gene Expression; D006801:Humans; D006825:Hybridomas; D008175:Lung Neoplasms / Q000276:immunology; D018168:Receptors, Retinoic Acid / Q000235:genetics; D000084562:Retinyl Esters; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D004224:Diterpenes; D018168:Receptors, Retinoic Acid; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D014212:Tretinoin