Effect of exogenous interleukin-18 (IL-18) and IL-12 in the course of Brucella abortus 2308 infection in mice.
In this study we demonstrated that combined inoculation of interleukin-12 (IL-12) and IL-18 reduced the number of bacteria in the spleens of mice infected with Brucella abortus 2308 and that the effect of the treatment was mediated by an increased capability of spleen cells to produce gamma interferon at the early phase of infection.
Pasquali
Paolo
P
Laboratory of Veterinary Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy. pasquali@iss.it
Adone
Rosanna
R
Gasbarre
Louis C
LC
Pistoia
Claudia
C
Ciuchini
Franco
F
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002003:Brucella abortus; D002006:Brucellosis / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D018664:Interleukin-12 / Q000494:pharmacology*; D020382:Interleukin-18 / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology
D000276:Adjuvants, Immunologic; D020382:Interleukin-18; D018664:Interleukin-12