title: MsqTc3, a Tc3-like transposon in the yellow fever mosquito Aedes aegypti.
abstract: A novel transposon, MsqTc3-Aa, has been discovered in the yellow fever mosquito, Aedes aegypti. Evidence of its past mobility is presented. There are approximately 100 copies of MsqTc3-Aa in A. aegypti, eight of which have been isolated and sequenced. All sequenced copies are more than 99% identical to their consensus, indicating recent mobilization. The MsqTc3-Aa consensus contains imperfect terminal inverted repeats (TIRs) and an open reading frame (ORF) interrupted by an intron. Sequence, structural and phylogenetic analysis showed that MsqTc3-Aa is a distant relative of Tc3, an active transposon in Caenorhabditis elegans. These results may provide useful information for the current effort to control mosquito-borne diseases using genetic approaches.
authors.affiliation: Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, USA.
authors.forename: H
authors.initials: H
authors.lastname: Shao
authors.forename: Y
authors.initials: Y
authors.lastname: Qi
authors.forename: Z
authors.initials: Z
authors.lastname: Tu
mesh_terms: D000330:Aedes / Q000145:classification / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D030801:Animals, Genetically Modified; D001483:Base Sequence; D017173:Caenorhabditis elegans / Q000235:genetics; D004251:DNA Transposable Elements; D019143:Evolution, Molecular; D007438:Introns; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004251:DNA Transposable Elements