Biology and significance of T-cell apoptosis in the liver.
The liver has emerged as an organ with distinct immunological properties. In this review, we summarize evidence that shows that the liver can remove apoptotic, or non-apoptotic but activated, CD8+ T cells from the circulation and induce apoptosis in these activated T cells by either active or passive mechanisms. Hepatitis viruses, particularly hepatitis C virus, often establish persistent infection. We review evidence that suggests that these viruses exploit intrahepatic tolerance mechanisms to protect themselves from immune attack.
Park
Sun
S
The David H Smith Center for VaccineBiology and Immunology, The University of Rochester, Rochester, New York 14642, USA.
Murray
Debbie
D
John
Beena
B
Crispe
I Nicholas
IN
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D016174:Hepacivirus / Q000276:immunology; D006801:Humans; D008099:Liver / Q000166:cytology / Q000276:immunology* / Q000821:virology