title: [Umbilical cord blood stem cells transplantation from an unrelated donor into an adult with severe aplastic anemia].
abstract: OBJECTIVE
  To evaluate the availability of the treatment of adult severe aplastic anemia with unrelated allo-cord blood stem cell transplantation (CBSCT).
  
  
  METHODS
  HLA-matched unrelated cord blood transplantation has been successfully performed for an adult severe aplastic anemia patient. A unit of cord blood provided by Guangzhou Cord Blood Bank containing 1.89 x 10(7)/kg mononucleated cells, 1.8 x 10(4)/kg CFU-GM and of CD(34) positive cells was 0.009. The patient was conditioned with CTX (60 mg/kg) and anti-lymphocyte globulin (ALG, 120 mg/kg). GVHD prophylaxis consisted of both MTX and CsA. The CsA had been given for 8 months.
  
  
  RESULTS
  The lowest ANC was 0.6 x 10(9)/L post-transplantation. The patient achieved an ANC of greater than 0.5 x 10(9)/L at 10 days, and the platelet of greater than 50.0 x 10(9)/L at day 20 after transplantation. He developed Grade 1 GVHD in the tenth month after grafting. Microsatellite DNA fingerprinting indicated a stable donor-recipient mixed chimerism, whilst the circulating red cells remained host origin.
  
  
  CONCLUSIONS
  It is the first report in China on successful treatment of adult severe aplastic anemia by unrelated allo-CBSCT.
authors.affiliation: First Municipal Peoples Hospital of Guangzhou, Guangzhou 510180, China.
authors.forename: P
authors.initials: P
authors.lastname: Mao
authors.forename: C
authors.initials: C
authors.lastname: Liao
authors.forename: Z
authors.initials: Z
authors.lastname: Zhu
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Mo
authors.forename: Y
authors.initials: Y
authors.lastname: Ying
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: B
authors.initials: B
authors.lastname: Liu
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood / Q000628:therapy*; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects; D016172:DNA Fingerprinting; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism; D006086:Graft vs Host Disease / Q000209:etiology / Q000235:genetics; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D013997:Time Factors; D018183:Transplantation Chimera / Q000235:genetics; D014184:Transplantation, Homologous; D016896:Treatment Outcome