title: Benign solitary fibrous pleural tumour. Evidence of primitive features and complex genomic imbalances, including loss of 20q.
abstract: OBJECTIVE
  Cytogenetic data on solitary fibrous tumours (SFT) are very limited. We studied a benign pleural SFT for its ultrastructural and immunohistochemical details, and made cytogenetic analyses for comparison with other genetic and ultrastructural studies of SFT.
  
  
  RESULTS
  Immunohistochemistry showed strong positivities for CD34 and vimentin, but no reactions with anti-cytokeratins and epithelial membrane antigens. Electron microscopy revealed primitive desmosomes in our SFT. The results thus evinced fibroblast-like cells with intermediate epithelial-mesenchymal character. Comparative genomic hybridization of the tumour revealed losses of 1p33-->pter, 17pter q21, entire copies of chromosomes 19 and 22, and gains of 1p21-p22, 2q23-q32.3, 3pl2-q13.2, 4p14-q28, 6p12-q21, 9p21-->pter and 13q21-q31. Furthermore, there was loss of 20q, as was previously reported elsewhere in a case of benign and a case of malignant SFT.
  
  
  CONCLUSIONS
  The results furnish further evidence of the involvement of -20q in SFT. In addition, they show that SFT may have complex genomic imbalances and primitive features, despite having a benign appearance.
authors.affiliation: Institute of Pathology, Medical Faculty, Aachen University of Technology, Germany. amo-takyi@pat.rwth-aachen.de
authors.forename: B K
authors.initials: BK
authors.lastname: Amo-Takyi
authors.forename: K
authors.initials: K
authors.lastname: Günther
authors.forename: I
authors.initials: I
authors.lastname: Peters
authors.forename: C
authors.initials: C
authors.lastname: Mittermayer
authors.forename: M
authors.initials: M
authors.lastname: Eblenkamp
authors.forename: L
authors.initials: L
authors.lastname: Tietze
mesh_terms: D002872:Chromosome Deletion; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D003896:Desmosomes / Q000648:ultrastructure; D004848:Epithelium; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D018218:Neoplasms, Fibrous Tissue / Q000235:genetics* / Q000473:pathology; D010997:Pleural Neoplasms / Q000235:genetics* / Q000473:pathology