[Characteristics of salivary protein spectrum in patients with depressive disorders (in search for biological markers of depression)].
Salivary protein spectrum was studied by polyacrylamide gel electrophoresis in 80 patients with psychogenic affective disorders, 80 with rheumatic and 10 with reactive arthritis, and 9 patients with chronic renal insufficiency in the presence of depression. Control group consisted of 60 healthy subjects. The results indicate that depression is associated with decreased content of protein in different fractions of the spectrum, the most marked decrease being observed for the fraction with molecular weight of about 55 kD. The optical density of this fraction decreases to 0.11 units in depression (versus 0.17 +/- 0.02 in the control), which suggests that this method can be used for the diagnosis of depressions.
Grigor'ev
I V
IV
Ulanova
E A
EA
Ladik
B B
BB
D000293:Adolescent; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D015415:Biomarkers; D003866:Depressive Disorder / Q000175:diagnosis / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012471:Salivary Proteins and Peptides / Q000032:analysis* / Q000378:metabolism
D015415:Biomarkers; D012471:Salivary Proteins and Peptides