High-quality life extension by the enzyme peptide methionine sulfoxide reductase.
Cumulative oxidative damages to cell constituents are considered to contribute to aging and age-related diseases. The enzyme peptide methionine sulfoxide reductase A (MSRA) catalyzes the repair of oxidized methionine in proteins by reducing methionine sulfoxide back to methionine. However, whether MSRA plays a role in the aging process is poorly understood. Here we report that overexpression of the msrA gene predominantly in the nervous system markedly extends the lifespan of the fruit fly Drosophila. The MSRA transgenic animals are more resistant to paraquat-induced oxidative stress, and the onset of senescence-induced decline in the general activity level and reproductive capacity is delayed markedly. The results suggest that oxidative damage is an important determinant of lifespan, and MSRA may be important in increasing the lifespan in other organisms including humans.
Ruan
Hongyu
H
Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA.
Tang
Xiang Dong
XD
Chen
Mai-Lei
ML
Joiner
Mei-Ling A
ML
Sun
Guangrong
G
Brot
Nathan
N
Weissbach
Herbert
H
Heinemann
Stefan H
SH
Iverson
Linda
L
Wu
Chun-Fang
CF
Hoshi
Toshinori
T
Chen
M-L
ML
Joiner
M A
MA
Heinemann
Stephen H
SH
D000818:Animals; D030801:Animals, Genetically Modified; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology; D008136:Longevity / Q000502:physiology; D051150:Methionine Sulfoxide Reductases; D010088:Oxidoreductases / Q000235:genetics / Q000502:physiology*; D010455:Peptides
D010455:Peptides; D010088:Oxidoreductases; D051150:Methionine Sulfoxide Reductases; C027219:methionine sulfoxide reductase