title: Effects of combination of low doses of angiotensin-converting enzyme inhibitor and diuretics on renal function in spontaneously hypertensive rats: comparison between acute and chronic treatment.
abstract: The goal of this study was to assess the effect of acute or chronic treatment with S5590, a combination of the angiotensin-converting enzyme inhibitor perindopril (0.76 mg/kg/day) and the diuretic indapamide (0.24 mg/kg/day) on renal function in spontaneously hypertensive rats with moderate renal injury. Renal function was evaluated in conscious rats by clearance methods using labelled inulin and PAH, after catheterisation of the carotid artery, jugular vein and bladder. Both acute and chronic treatment normalised renal vascular resistance, although the effect on blood pressure was more marked after chronic than after acute treatment. Although acute treatment with S5590 increased glomerular filtration rate and renal blood flow, chronic treatment did not affect these parameters. Diuresis and natriuresis were only slightly modified and the results suggest a marked renal vasodilatation. In conclusion, the maintenance of renal function after chronic treatment, in a setting of normalisation of arterial pressure, suggest that such a combined treatment may exert marked renal functional protective effects in hypertension.
authors.affiliation: Department of Pharmacology, Rouen University Medical School, Rouen, France. jean.doucet@chu-rouen.fr
authors.forename: J
authors.initials: J
authors.lastname: Doucet
authors.forename: V
authors.initials: V
authors.lastname: Richard
authors.forename: P
authors.initials: P
authors.lastname: Mulder
authors.forename: J P
authors.initials: JP
authors.lastname: Henry
authors.forename: P
authors.initials: P
authors.lastname: Schiavi
authors.forename: D
authors.initials: D
authors.lastname: Guez
authors.forename: C
authors.initials: C
authors.lastname: Thuillez
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006973:Hypertension / Q000188:drug therapy*; D007190:Indapamide / Q000494:pharmacology*; D007668:Kidney / Q000502:physiology; D009318:Natriuresis / Q000187:drug effects; D020913:Perindopril / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D004338:Drug Combinations; C494243:indapamide, perindopril drug combination; D007190:Indapamide; D020913:Perindopril