title: Eupha-7,9(11),24-trien-3beta-ol ("antiquol C") and other triterpenes from Euphorbia antiquorum latex and their inhibitory effects on Epstein-Barr virus activation.
abstract: The structures of three triterpene alcohols isolated from the latex of Euphorbia antiquorum were established to be eupha-7,9(11),24-trien-3beta-ol (2; antiquol C), 19(10-->9)abeo-8alpha,9beta,10alpha-eupha-5,24-dien-3beta-ol (3; antiquol B), and 24-methyltirucalla-8,24(24(1))-dien-3beta-ol (4; euphorbol) on the basis of spectroscopic methods. Compounds 3 and 4 have previously been assigned the erroneous structures of 10alpha-cucurbita-5,24-dien-3alpha-ol and 24-methyleupha-8,24(24(1))-dien-3beta-ol, respectively. Compounds 2-4 and four other known compounds isolated from the latex, euphol (1), lemmaphylla-7,21-dien-3beta-ol (5), isohelianol (6), and camelliol C (7), showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).
authors.affiliation: College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan. akihisa@chem.cst.nihon-u.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Akihisa
authors.forename: E M
authors.initials: EM
authors.lastname: Kithsiri Wijeratne
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Fumio
authors.initials: F
authors.lastname: Enjo
authors.forename: Masakazu
authors.initials: M
authors.lastname: Toriumi
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kimura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Koike
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Nikaido
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tezuka
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
mesh_terms: D000956:Antigens, Viral / Q000032:analysis / Q000187:drug effects; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D028481:Euphorbia / Q000737:chemistry*; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007840:Latex / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D009303:Nasopharyngeal Neoplasms; D019906:Nuclear Magnetic Resonance, Biomolecular; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013188:Sri Lanka; D013237:Stereoisomerism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000956:Antigens, Viral; D000998:Antiviral Agents; C033305:Epstein-Barr virus early antigen; D007840:Latex; D013755:Tetradecanoylphorbol Acetate