title: Impact of insulin resistance on neointimal tissue proliferation after coronary stent implantation. Intravascular ultrasound studies.
abstract: Serial intravascular ultrasound (IVUS) studies in 55 nondiabetic patients showed that neointimal tissue proliferation after stent implantation in patients with impaired glucose tolerance (IGT) was greater than that in patients with normal glucose tolerance at follow-up. Multiple regression analysis showed that the sum of insulin levels was the best predictor of the greater neointimal index at follow-up. Another group of serial IVUS studies were performed in 62 stented lesions in 52 patients with Type 2 diabetes mellitus (DM). The study patients were randomized into a troglitazone group and a control group. The neointimal tissue proliferation at follow-up in the troglitazone group was significantly smaller than that in the control group.
authors.affiliation: Division of Cardiology, Kobe General Hospital, Minatojima Nakamachi 4-6, Chuo-Ku, Kobe, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takagi
authors.forename: Takashi
authors.initials: T
authors.lastname: Akasaka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamamuro
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Honda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hozumi
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Morioka
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yoshida
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D002455:Cell Division; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D006946:Hyperinsulinism / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology*; D015607:Stents; D017539:Tunica Intima / Q000473:pathology*; D014463:Ultrasonography
chemical_list: D001786:Blood Glucose