Stereospecific synthesis of (+)-oxybiotin from D-xylose.
A new 14-step synthesis of (+)-oxybiotin, an oxygen analogue of (+)-biotin, was achieved starting from D-xylose by use of selected 2,5-anhydro sugar derivatives as key intermediates.
Popsavin
Velimir
V
Faculty of Sciences, Institute of Chemistry, University of Novi Sad, Trg D. Obradovica 3, YU-21000, Novi Sad, Yugoslavia. popsavin@ih.ns.ac.yu
Benedeković
Goran
G
Popsavin
Mirjana
M
Miljković
Dusan
D
D001710:Biotin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D014994:Xylose / Q000737:chemistry*
C460519:oxybiotin; D001710:Biotin; D014994:Xylose