[Genetic epidemiological study on non-insulin dependent diabetes mellitus].
OBJECTIVE
To study the general genetic pattern of non-insulin dependent diabetes mellitus patients.


METHODS
1,608 children were investigated for NIDDM family history, and 280 nuclear families were collected.


RESULTS
The prevalence rates of NIDDM among first-degree relatives (2.38%), the parents (26.00%), the siblings (2.44%) and the offsprings (1.24%) were higher than that in general population respectively. The s/q was 10.17 by Penrose method, which was close to 1/q(1/2). The p(0) was 0.0244 by simple segregation analysis, which was lower than 0.10. The heritability of NIDDM was 0.54, using the Falconer Threshold Model.


CONCLUSIONS
NIDDM has a familial aggregation, but not fit to the mono-genetic models. NIDDM has the feature of multifactorial inheritance.
Ouyang
F
F
Department of Child and Adolescent Health, Shanghai Medical University, Shanghai 200032, China.
Wang
W
W
Shen
F
F
Wang
L
L
Wang
Z
Z
D000328:Adult; D000368:Aged; D002648:Child; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics*; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012494:Sampling Studies