[Neural transplantation for cerebral ischemia/infarction--the present situation and prospects].
Cerebral infarction results in multiple symptoms including hemiplegia and cognitive disturbances. The central nervous system has a limited capacity for self-repair, thus there is a great interest in the possibility of repairing the central nervous system by neural transplantation. Two different types of cerebral infarction model are well investigated for neural transplantation. Several kinds of donor cells have been used to try to restore the brain damage after ischemic insult. Reconstruction of neural circuits by transplantation is an ideal goal for the treatment of cerebral infarction, but trophic action of transplantation is also expected. Amelioration of ischemia-induced brain damage and recovery of neural dysfunction are documented. However, there are several factors and problems to be solved for clinical application.
Aihara
Noritaka
N
Department of Neurosurgery, Nagoya City University Medical School.
Yamada
Kazuo
K
Nishino
Hitoo
H
D000818:Animals; D002545:Brain Ischemia / Q000601:surgery*; D002544:Cerebral Infarction / Q000601:surgery*; D009474:Neurons / Q000637:transplantation*; D051381:Rats