title: Ovarian cancer in BRCA-positive women: vigilance is mandatory despite screening programs.
abstract: A young BRCA-1 positive woman turned out to have advanced stage ovarian cancer despite an ensuring check-up 4 months earlier. Much remains unknown regarding the efficacy of screening programs, when applied to individuals predisposed for an inherited malignancy. Therefore, vigilance is mandatory when dealing with women with a positive family history of mammarian and/or ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynaecology, Isala Clinics, Location Sophia, Dr. Van Heesweg 2, 8025 AB, Zwolle, The Netherlands.
authors.forename: Karin
authors.initials: K
authors.lastname: Sloots
authors.forename: Margreet G E M
authors.initials: MG
authors.lastname: Ausems
authors.forename: Harm H
authors.initials: HH
authors.lastname: de Haan
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D005260:Female; D019398:Genes, BRCA1; D006801:Humans; D007044:Hysterectomy; D008403:Mass Screening; D009154:Mutation; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D017239:Paclitaxel / Q000627:therapeutic use
chemical_list: D017239:Paclitaxel; D002945:Cisplatin