[Study on the expression of integrin alpha(5), beta(1) during wound healing].
OBJECTIVE
To explore the potential role of integrin family in mediating the interaction between cells and extracellular matrix (ECM) during wound healing.


METHODS
In situ hybridization technique was employed in the determination of the expression of the mRNA of the subunits of integrin alpha(5), beta(1) on the surface of fibroblasts in the donor sites of partial thickness skin of 12 burned patients.


RESULTS
Evidently more integrin alpha(5), beta(1) positive staining fibroblasts were found in the donor site than in normal skin (P < 0.05).


CONCLUSIONS
The results suggested that increased expression of integrin alpha(5), beta(1) in the wound might be involved in the activation of collagen-- overproductive subpopulation of fibroblasts.
Chen
M
M
Department of Plastic and Reconstructive Surgery, Third School of Clinical Medicine, Beijing Medical University, Beijing 100083, China.
Niu
X
X
Lin
Z
Z
D000293:Adolescent; D000328:Adult; D002648:Child; D003094:Collagen / Q000096:biosynthesis; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis; D017469:Receptors, Fibronectin / Q000235:genetics*; D014945:Wound Healing / Q000502:physiology*
D012333:RNA, Messenger; D017469:Receptors, Fibronectin; D003094:Collagen