Altered constitutive and activation-induced expression of CD95 by B- and T-cells in B-cell chronic lymphocytic leukemia.
Expression of CD95, a molecule involved in activation-induced cell death (AICD), might contribute to explain accumulation of leukemic B-cells and functional impairment of T-cells in B-cell chronic lymphocytic leukemia (B-CLL). There-fore, we compared constitutive and activation-induced expression of CD95 and CD69 by B- and T-cells in CLL patients and in healthy donors.
De Fanis
Umberto
U
Dalla Mora
Liliana
L
Romano
Ciro
C
Sellitto
Ausilia
A
Tirelli
Angelo
A
Lucivero
Giacomo
G
D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D037181:Lectins, C-Type; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology / Q000378:metabolism*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D019014:fas Receptor / Q000096:biosynthesis*; D000099192:CD69 Antigens
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D037181:Lectins, C-Type; D019014:fas Receptor; D000099192:CD69 Antigens