title: Secondary erythrocytosis associated with high plasma erythropoietin concentrations in a dog with cecal leiomyosarcoma.
abstract: A 14-year-old mixed-breed dog was examined because of severe absolute erythrocytosis (PCV, 70%). Plasma erythropoietin (EPO) concentration was consistently high, even though results of arterial blood gas analyses were normal. Radiography, ultrasonography, urinalysis, and serum biochemical analyses did not reveal any cardiac, pulmonary, or renal abnormalities that could cause the erythrocytosis, and erythrocytosis secondary to inappropriate EPO secretion was diagnosed. The PCV was maintained at approximately 60% by means of periodic phlebotomy, and the dog died of acute renal failure 2 years later. At necropsy, a cecal leiomyosarcoma was identified. Immunohistochemical staining of sections of the tumor revealed intracellular vacuoles containing EPO, and EPO mRNA was detected in the tumor by use of a reverse transcriptase-polymerase chain reaction assay These results suggested that ectopic production of EPO by a cecal leiomyosarcoma was the cause of erythrocytosis in this dog.
authors.affiliation: Department of Veterinary Internal Medicine, Faculty of Agriculture, Tottori University, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Sato
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hikasa
authors.forename: Takehito
authors.initials: T
authors.lastname: Morita
authors.forename: Akinori
authors.initials: A
authors.lastname: Shimada
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Ozaki
authors.forename: Katsumoto
authors.initials: K
authors.lastname: Kagota
mesh_terms: D000818:Animals; D002430:Cecal Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood / Q000209:etiology*; D004285:Dogs; D004921:Erythropoietin / Q000097:blood*; D017809:Fatal Outcome; D007150:Immunohistochemistry / Q000662:veterinary; D007890:Leiomyosarcoma / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008297:Male; D011086:Polycythemia / Q000209:etiology / Q000662:veterinary*; D016133:Polymerase Chain Reaction / Q000662:veterinary
chemical_list: D004921:Erythropoietin