Type 1 diabetes mellitus and epilepsia partialis continua in a 6-year-old boy with elevated anti-GAD65 antibodies.
A 6-year-old boy presented with epilepsia partialis continua 6 months after diagnosis of type 1 diabetes. Anti-glutamic acid decarboxylase 65 antibodies were found in his serum and cerebrospinal fluid. Anti-epileptic agents did not improve his seizures. High-dose steroids, plasmapheresis, and intravenous immunoglobulin resulted in decreased anti-glutamic acid decarboxylase 65 antibody levels and resolution of his seizures.
Olson
Jennifer A
JA
Department of Pediatrics, Division of Endocrinology, Lucile Packard Children's Hospital at Stanford, Stanford, California, USA. jolson@valleychildrens.org
Olson
Donald M
DM
Sandborg
Christy
C
Alexander
Steven
S
Buckingham
Bruce
B
D001323:Autoantibodies / Q000097:blood*; D001921:Brain / Q000473:pathology; D002648:Child; D003131:Combined Modality Therapy; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D017036:Epilepsia Partialis Continua / Q000276:immunology* / Q000628:therapy; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007527:Isoenzymes / Q000276:immunology*; D008297:Male; D010956:Plasmapheresis; D011239:Prednisolone / Q000627:therapeutic use
D001323:Autoantibodies; D016756:Immunoglobulins, Intravenous; D007527:Isoenzymes; D011239:Prednisolone; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2