title: Psychopathological dimensions of depression: a factor study of the 17-item Hamilton depression rating scale in unipolar depressed outpatients.
abstract: BACKGROUND
  Agreement on the factor structure of the Hamilton Depression Rating Scale (HDRS) has not been consistent among studies, and some investigators argued that the scale's factor structure is not reliable. This study aimed at shedding more light on this debated issue.
  
  
  METHODS
  We studied 186 adults with unipolar depression (Major Depressive Disorder, n=80; Dysthymic Disorder, n=71; Depressive Disorder Not Otherwise Specified, n=25; Adjustment Disorder, n=10). They had no comorbid DSM-IV axis I or axis II disorders, and had received no treatment with antidepressant drugs in the previous 2 months. The factor structure of the scale was studied using the principal factor method, followed by oblique rotation. Factor scores were computed for each subject using the regression method.
  
  
  RESULTS
  Using the scree-test criterion for factor extraction, we obtained a four-factor solution, explaining 43.8% of total variance. The four factors extracted were identified as (1) somatic anxiety/somatization factor; (2) a psychic anxiety dimension; (3) a pure depressive dimension; and (4) anorexia factor. Patients with Major Depressive Disorder scored significantly higher than patients with other diagnoses on the pure depressive dimension.
  
  
  CONCLUSIONS
  These results need to be replicated in different cultures, using analogous factoring techniques.
  
  
  CONCLUSIONS
  Though not exhibiting factorial invariance in the stricter sense of the term, the 17-item HDRS did exhibit a relatively reliable factor structure. Our analysis provides further evidence that the scale is multidimensional. However, as long as the multidimensional character of the scale is taken into account the scale should be able to play a useful role in clinical research.
authors.affiliation: Università La Sapienza, Dipartimento di Scienze Psichiatriche Medicina Psicologica, III Clinica Psichiatrica, Viale dell'Università, 30-00185 Roma, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Pancheri
authors.forename: A
authors.initials: A
authors.lastname: Picardi
authors.forename: M
authors.initials: M
authors.lastname: Pasquini
authors.forename: P
authors.initials: P
authors.lastname: Gaetano
authors.forename: M
authors.initials: M
authors.lastname: Biondi
mesh_terms: D000328:Adult; D000855:Anorexia / Q000523:psychology; D001007:Anxiety / Q000523:psychology; D003866:Depressive Disorder / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index