title: [Chromosome t (8; 21) and t (15; 17) in a patient with acute myeloid leukemia].
abstract: OBJECTIVE
  To report an acute myeloid leukemia (AML) patient with both chromosome t (8; 21) and t (15; 17).
  
  
  METHODS
  Chromosome specimen was prepared by short-term culture of bone marrow cells, karyotype analyses by R-banding technique, and fusion genes by reverse transcriptase-polymerase chain reaction (RT-PCR).
  
  
  RESULTS
  Karyotype analyses showed the appearance of 45, X, -X, t (8; 21), t (15; 17), and RT-PCR assay revealed AML1/ETO and PML-RARalpha fusion gene transcripts.
  
  
  CONCLUSIONS
  AML with both t (8; 21) and t (15; 17) might be recognized as a a novel subtype of acute leukemias.
authors.affiliation: Shanghai First People Hospital, Shanghai 200080, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Gao
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.forename: Q
authors.initials: Q
authors.lastname: Cao
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
authors.forename: Q
authors.initials: Q
authors.lastname: Cai
authors.forename: S
authors.initials: S
authors.lastname: Yan
authors.forename: X
authors.initials: X
authors.lastname: Yang
mesh_terms: D001854:Bone Marrow Cells / Q000166:cytology; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D014178:Translocation, Genetic; D055815:Young Adult