title: Fourier analysis reveals increased trabecular spacing in sickle cell anemia.
abstract: Sickle cell anemia may expand marrow spaces in the jaws. Fourier analysis is well-suited to the analysis of trabecular spacing in radiographs. We hypothesize that individuals with sickle cell anemia demonstrate increased intertrabecular spacing. Periapical radiographs of 18 African Americans with sickle cell disease and 18 controls were examined by one-dimensional discrete Fourier analyses in both jaws for measurement of the spatial frequency distribution of repeating trabecular structures. A strut analysis of trabeculae was also performed and the results compared. Trabecular structures in individuals with sickle cell anemia revealed increased intertrabecular distance compared with controls. Strut analysis revealed significant reductions in trabecular complexity. Fourier analysis allows for the classification of subjects with 94% sensitivity and specificity. Fourier analysis of dental radiographs is a more effective method of identifying individuals with sickle cell anemia than strut analysis.
authors.affiliation: Section of Oral and Maxillofacial Radiology, UCLA School of Dentistry, Los Angeles, CA 90095-1668, USA.
authors.forename: T D
authors.initials: TD
authors.lastname: Faber
authors.forename: D C
authors.initials: DC
authors.lastname: Yoon
authors.forename: S C
authors.initials: SC
authors.lastname: White
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000000981:diagnostic imaging*; D001853:Bone Marrow / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging*; D008437:Maxilla / Q000000981:diagnostic imaging*; D016011:Normal Distribution; D011237:Predictive Value of Tests; D011856:Radiographic Image Enhancement / Q000379:methods; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D013382:Subtraction Technique