title: Age at onset in two common neurodegenerative diseases is genetically controlled.
abstract: To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) and Parkinson disease (PD; n=174). Heritabilities between 40%--60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D10S1239 and D10S1237, with a maximum LOD score of 2.62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.
authors.affiliation: Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Yi-Ju
authors.initials: YJ
authors.lastname: Li
authors.forename: William K
authors.initials: WK
authors.lastname: Scott
authors.forename: Dale J
authors.initials: DJ
authors.lastname: Hedges
authors.forename: Fengyu
authors.initials: F
authors.lastname: Zhang
authors.forename: P Craig
authors.initials: PC
authors.lastname: Gaskell
authors.forename: Martha A
authors.initials: MA
authors.lastname: Nance
authors.forename: Ray L
authors.initials: RL
authors.lastname: Watts
authors.forename: Jean P
authors.initials: JP
authors.lastname: Hubble
authors.forename: William C
authors.initials: WC
authors.lastname: Koller
authors.forename: Rajesh
authors.initials: R
authors.lastname: Pahwa
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Stern
authors.forename: Bradley C
authors.initials: BC
authors.lastname: Hiner
authors.forename: Joseph
authors.initials: J
authors.lastname: Jankovic
authors.forename: Fred A
authors.initials: FA
authors.lastname: Allen
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Goetz
authors.forename: Frank
authors.initials: F
authors.lastname: Mastaglia
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Stajich
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Gibson
authors.forename: Lefkos T
authors.initials: LT
authors.lastname: Middleton
authors.forename: Ann M
authors.initials: AM
authors.lastname: Saunders
authors.forename: Burton L
authors.initials: BL
authors.lastname: Scott
authors.forename: Gary W
authors.initials: GW
authors.lastname: Small
authors.forename: Kristin K
authors.initials: KK
authors.lastname: Nicodemus
authors.forename: Allison D
authors.initials: AD
authors.lastname: Reed
authors.forename: Donald E
authors.initials: DE
authors.lastname: Schmechel
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Welsh-Bohmer
authors.forename: P Michael
authors.initials: PM
authors.lastname: Conneally
authors.forename: Allen D
authors.initials: AD
authors.lastname: Roses
authors.forename: John R
authors.initials: JR
authors.lastname: Gilbert
authors.forename: Jeffery M
authors.initials: JM
authors.lastname: Vance
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Haines
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Pericak-Vance
mesh_terms: D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008875:Middle Aged; D008957:Models, Genetic; D020412:Multifactorial Inheritance; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E