title: [A case of FK 506-induced leukoencephalopathy].
abstract: We reported a 15-year-old boy with an acute myelomonocytic leukemia and FK 506-induced leukoencephalopathy. He was received FK 506 for graft versus host disease occurred after peripheral blood stem cell transplantation. He, four weeks later, had generalized seizures and consciousness disturbance. The serum level of FK 506 was high (27.5 ng/ml). His brain MRI showed abnormal high intensity areas in the frontal and parietal white matter lesions on T2-weighted images. Neuropathological studies revealed the destruction of myelin sheeths and axons in the cerebral white matter corresponded with abnormal lesions on MRI. There were calcification and mineralization in the small vessel walls of the cortex and white matter. Osteopontin immunoreactivity was detected in the endothelial cells of small vessels. These findings suggest that the vascular damage was involved in the FK 506-induced leukoencephalopathy.
authors.affiliation: Department of Hematology and Oncology, Chiba Children's Hospital.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Okoshi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Itoh
authors.forename: Yuri
authors.initials: Y
authors.lastname: Okimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Horie
authors.forename: Sachio
authors.initials: S
authors.lastname: Takashima
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis; D006086:Graft vs Host Disease / Q000188:drug therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015479:Leukemia, Myelomonocytic, Acute / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus