title: Progression on metastatic neuroendocrine carcinoma from a recurrent prolactinoma: a case report.
abstract: A 54 year old man was referred to the department of neurosurgery for frontal headache and vomiting. The patient was known in the department because of previous multiple surgery for a locally invasive pituitary prolactinoma (eight years, three years, and one year previously). The neurological examination revealed a frontal mass, which adhered to the dura, suggesting a meningioma. One year later, a left temporal metastasis was removed. Three months later, the patient died, with spinal metastases, of massive lung embolism. Histology revealed a progression of adenohypophyseal prolactinoma on neuroendocrine carcinoma, with an increase in proliferating indexes and modification of hormone production. This study documents a 10 year history of a rare prolactin producing pituitary carcinoma, which metastasised via liquoral flow.
authors.affiliation: Department of Pathology, Legnano General Hospital, Legnano, Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Sironi
authors.forename: G
authors.initials: G
authors.lastname: Cenacchi
authors.forename: L
authors.initials: L
authors.lastname: Cozzi
authors.forename: G
authors.initials: G
authors.lastname: Tonnarelli
authors.forename: M
authors.initials: M
authors.lastname: Iacobellis
authors.forename: D
authors.initials: D
authors.lastname: Treré
authors.forename: A
authors.initials: A
authors.lastname: Assi
mesh_terms: D018278:Carcinoma, Neuroendocrine / Q000473:pathology / Q000556:secondary*; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000473:pathology*; D015175:Prolactinoma / Q000473:pathology*