A granuloma annulare-like eruption associated with the use of amlodipine.
A granuloma annulare-like drug reaction is a rarely encountered clinical entity. A 64-year-old Caucasian female developed a granuloma annulare-like reaction 13 days after starting amlodipine and cleared within 3 months after drug cessation. The eruption consisted of multiple erythematous pruritic papules, distributed symmetrically over the lateral aspects of the legs and thighs, as well as on both palms. Histology showed focal collagen degeneration and significant interstitial histiocytic dermal infiltrate suggestive of granuloma annulare. We review previously reported cases of granuloma annulare-like drug reactions, in the context of a recently proposed classification for drug-induced interstitial granulomatous reactions.
Lim
Adrian C
AC
Department of Dermatology, St George Hospital Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Hart
Kim
K
Murrell
Dédée
D
D017311:Amlodipine / Q000009:adverse effects* / Q000627:therapeutic use; D001707:Biopsy, Needle; D002121:Calcium Channel Blockers / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D016460:Granuloma Annulare / Q000139:chemically induced* / Q000473:pathology; D006229:Hand Dermatoses / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007868:Leg Dermatoses / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index
D002121:Calcium Channel Blockers; D017311:Amlodipine