Guidelines for evaluation of patients at risk for inherited breast and ovarian cancer: recommendations of the Department of Defense Familial Breast/Ovarian Cancer Research Project.
Patients at high risk for inherited breast and/or ovarian cancer are frequently encountered in all medical specialties. Department of Defense, Health Affairs funding as part of the Breast Cancer Education and Awareness Program was used to develop a comprehensive program for the identification, counseling, genetic testing, and long-term follow-up of such high-risk patients. This article reports the recommendations for high-risk patient management based on 4 years of evaluation and care, including discussions of the approach to counseling, indications for genetic testing, post-testing counseling, patient surveillance with examination, imagining, and laboratory testing, and suggested options for surgical and chemoprophylaxis as well as lifestyle modifications.
Fries
Melissa H
MH
Air Force Medical Genetics Center, Keesler Air Force Base, MS 39534, USA.
Holt
Charlene
C
Carpenter
Isabelle
I
Carter
Cindy L
CL
Daniels
Jamelyn
J
Flanagan
Judith
J
Murphy
Kay
K
Hailey
B Jo
BJ
Martin
Laura
L
Hume
Roderick
R
Hudson
Gracia
G
Cadman
Mary
M
Weatherly
Ronald
R
Nunes
Mark E
ME
D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control*; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005820:Genetic Testing; D017408:Guidelines as Topic; D006801:Humans; D008408:Mastectomy / Q000379:methods; D010051:Ovarian Neoplasms / Q000235:genetics / Q000517:prevention & control*; D010375:Pedigree; D017410:Practice Guidelines as Topic / Q000592:standards*; D013629:Tamoxifen / Q000008:administration & dosage
D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen