title: Cold-adapted influenza vaccines.
abstract: Because of the health impact of complicated disease from influenza in children, the role played by children in spreading influenza, and the limitations of inactivated influenza vaccine in this population, there has been ongoing effort to identify a more effective and acceptable vaccine. This review will focus on the development, limitations, and potential of a leading candidate vaccine studied in children. This is a live, attenuated, intranasally administered cold-adapted influenza vaccine.
authors.affiliation: Division Infectious Disease, Department of Pediatrics, Pathology, and Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: John
authors.initials: J
authors.lastname: Bradshaw
authors.forename: Peter F
authors.initials: PF
authors.lastname: Wright
mesh_terms: D000281:Administration, Intranasal; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control*; D014613:Vaccines, Attenuated / Q000008:administration & dosage
chemical_list: D007252:Influenza Vaccines; D014613:Vaccines, Attenuated