title: [Epidemiologic effectivness of poludane in preventing influenza and other acute respiratory diseases in troops].
abstract: The epidemiological effectiveness of interferon inductor "Poludanum" produced by "LENS Pharm" (Russia) for prevention of acute respiratory viral infections was tested. The drug was administered among the students of Military Medical Academy (101 students) according to scheme 1: in a nose, 3 drops in each nasal passage two times per week during 4 weeks, with 2 week interruption then the scheme was repeated. The scheme 2 included 3 drops in each nasal passage once a week during 10 weeks (95 students). The placebo group (96 students) received the distilled water. In the students receiving "Poludanum" according to scheme 1 the incidence of acute respiratory diseases (ARD) was significantly lower than in the control group (p = 0.058). The coefficient of effectiveness was 50%, i.e. the incidence has decreased in two times. The use of poludanum according to scheme 2 caused no decrease in ARD incidence.
authors.forename: V I
authors.initials: VI
authors.lastname: Shumilov
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Ivannikov
authors.forename: P I
authors.initials: PI
authors.lastname: Ogarkov
authors.forename: S P
authors.initials: SP
authors.lastname: Lobastov
authors.forename: V V
authors.initials: VV
authors.lastname: Olontsev
mesh_terms: D000208:Acute Disease; D000998:Antiviral Agents / Q000627:therapeutic use*; D006801:Humans; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control*; D007369:Interferon Inducers / Q000627:therapeutic use*; D008889:Military Personnel; D011131:Polyribonucleotides / Q000627:therapeutic use*; D012140:Respiratory Tract Diseases / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D000998:Antiviral Agents; D007369:Interferon Inducers; D011131:Polyribonucleotides; C044366:poludan