Do interleukin-1 polymorphisms predict the development of periodontitis or the success of dental implants?
Factors which increase the risk of severe adult periodontitis (AP) may also contribute to the success of dental implants. To determine which cytokines may be relevant, levels of interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta), interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6) and interferon-gamma (IFN-gamma) mRNA were quantitated in gingival tissue from periodontitis patients and healthy controls. Periodontitis significantly increased levels of IL-1alpha, IL-1beta, IL-6 and IFN-gamma mRNA relative to healthy tissues. IL-1 was selected for further study, as it has inflammatory and bone resorbing properties. We examined IL-1A(-889) and IL-1B(+3953) alleles in Caucasian patients with AP and early-onset periodontitis (EOP), patients with dental implants and healthy individuals. The IL-1B(+3953) polymorphism was associated with AP. This was evident from an increased homozygosity for allele 2 in patients with AP and a decreased heterozygosity in advanced AP patients. IL-1A(-889) and a composite genotype [IL-1A(-889)2 plus IL-1B(+3953)2] showed no association with the incidence of periodontitis, disease onset or disease severity. IL-1A(-889), IL-1B(+3953) and the composite genotype also showed no association with failure of dental implants.
Rogers
Marina A
MA
Department of Pathology, University of Western Australia, Perth, Australia.
Figliomeni
Lisa
L
Baluchova
Katarina
K
Tan
Albert E S
AE
Davies
Gareth
G
Henry
Patrick J
PJ
Price
Patricia
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D010520:Aggressive Periodontitis / Q000235:genetics / Q000276:immunology; D000483:Alleles; D016022:Case-Control Studies; D015921:Dental Implants; D019232:Dental Restoration Failure; D005260:Female; D005544:Forecasting; D005838:Genotype; D005881:Gingiva / Q000737:chemistry; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000235:genetics*; D015850:Interleukin-6 / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D011110:Polymorphism, Genetic / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors; D012307:Risk Factors; D012795:Sialoglycoproteins / Q000032:analysis; D016896:Treatment Outcome
D015921:Dental Implants; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D015850:Interleukin-6; D012333:RNA, Messenger; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; D007371:Interferon-gamma