[Treatment of severe inhalation injury with endotracheal infusion of exogenous pulmonary surfactant].
OBJECTIVE
To explore the possibility and the effects of clinical application of exogenous pulmonary surfactant (PS).


METHODS
Two burned patients with severe inhalation injury were treated with 5% emulsified porcine PS by endotracheal infusion of 10 ml every 2 hours with the assistance of mechanical ventilation. The indices of patients' oxygenation and related pulmonary dynamics were observed.


RESULTS
Twenty-four hours after the application of exogenous PS, PaO(2) and PaO(2)/FiO(2) increased evidently, but (A -- a) DO(2) and RI decreased obviously and PaCO(2) sustained for the observing period. The index related pulmonary dynamics, DeltaV/DeltaP increased gradually.


CONCLUSIONS
With the assistance of mechanical ventilation, endotracheal infusion of exogenous PS could improve oxygenation and compliance of patients with severe inhalation injury. And the patients exhibited very good tolerance to exogenous PS.
Luo
Q
Q
Institute of Burn Research, Sonthwestern Hospital, The Third Military Medical University, Chongqing 400038, P.R China.
Liu
Z
Z
Yang
Z
Z
D000328:Adult; D002059:Burns, Inhalation / Q000188:drug therapy* / Q000503:physiopathology; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006801:Humans; D008170:Lung Compliance / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D014132:Trachea / Q000187:drug effects
D011663:Pulmonary Surfactants; D002245:Carbon Dioxide; D010100:Oxygen