[Receptors of selected cytokines and angiokine bFGF in patients with colorectal cancer (a preliminary study)].
The aim of the study was to examine the frequency of increased serum levels of the soluble receptors TNF and IL-2 and angiokine bFGF in colorectal cancer patients. Also correlation between their concentrations and stage of the tumor was made. The study was done on group consisted of 30 diagnosed colorectal cancer patients, with different location and stage of the tumor. The used classification of stage of the tumor was described by Dukes. The results were compared with control group consisted of 10 healthy persons. The examined factors were assayed by ELISA method (R&D Systems Minneapolis). In colorectal cancer group the serum levels of sTNFRI were increased 1.8 times, sTNFRII 1.4 times, sIL-2R 2.2 times and bFGF 5.3 times in comparison with control group. The serum levels of sTNFRI and sTNFRII showed increased tendency in stage D of colorectal cancer. The serum levels of sIL-2R were the highest in stage D. The serum levels of bFGF showed increased tendency in stage A and B and correlated with stage D of the tumor. This results permit for further study on usefulness of sTNFRI, sTNFRII, sIL-2R and bFGF as a markers for colorectal cancer in clinical use.
Grotowski
M
M
Klinika Chirurgiczna Wojskowego Instytutu Medycyny Lotniczej w Warszawie.
Piechota
W
W
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000097:blood*; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014408:Biomarkers, Tumor; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D016222:Fibroblast Growth Factor 2