title: DNA polymerase beta.
abstract: Mammalian DNA polymerase beta(beta-pol) is a single polypeptide chain enzyme of 39kDa. beta-pol has enzymatic activities appropriate for roles in base excision repair and other DNA metabolism events involving gap-filling DNA synthesis. Many crystal structures of beta-pol complexed with dNTP and DNA substrates have been solved, and mouse fibroblast cell lines deleted in the beta-pol gene have been examined. These approaches have enhanced our understanding of structural and functional aspects of beta-pol's role in protecting genomic DNA.
authors.affiliation: Laboratory of Structural Biology, NIEHS/NIH, Research Triangle Park, North Carolina, NC 29907, USA. myersh@niehs.nih.gov
authors.forename: Haitham T
authors.initials: HT
authors.lastname: Idriss
authors.forename: Osama
authors.initials: O
authors.lastname: Al-Assar
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Wilson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019951:DNA Polymerase beta / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004260:DNA Repair; D021881:DNA, Catalytic / Q000378:metabolism; D005091:Exons; D006801:Humans; D008190:Lyases / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D008970:Molecular Weight; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
chemical_list: D021881:DNA, Catalytic; D019951:DNA Polymerase beta; D008190:Lyases