Synthesis and in vitro tuberculostatic activity of Co (II), Cu (II) and Ni (II) complexes of dialdehyde starch dithiosemicarbazone.
Co (II), Cu (II) and Ni (II) complexes of starch dialdehyde dithiosemicarbazone (DASTSC) of low (approximately 15%) degree of oxidation were prepared and their tuberculostatic activity was tested in vitro against isoniazid-sensitive and isoniazid-resistant strains of Mycobacterium tuberculosis. In 10-week lasting tests the DASTSC complex with Ni (II) was tuberculostatic to a similar extent as was the free ligand, whereas the Co (II) and Cu (II) complexes inhibited the growth of M. tuberculosis more efficiently. It was also proved that the corresponding non-co-ordinated metal salts were inactive to both strains of M. tuberculosis.
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Department of Chemistry, University of Agriculture, Cracow, Poland.
Klisiewicz-Pańszczyk
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Jurek
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D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002614:Chelating Agents / Q000737:chemistry*; D003035:Cobalt; D003300:Copper; D024881:Drug Resistance, Bacterial; D066298:In Vitro Techniques; D007538:Isoniazid / Q000494:pharmacology; D008024:Ligands; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009532:Nickel; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000995:Antitubercular Agents; D002614:Chelating Agents; D008024:Ligands; D009942:Organometallic Compounds; D011134:Polysaccharides; D013882:Thiosemicarbazones; D003035:Cobalt; D003300:Copper; D009532:Nickel; D007538:Isoniazid