title: Epigenetic reprogramming in the mammalian embryo: struggle of the clones.
abstract: During preimplantation development in mammals, distinct epigenetic marks on oocyte and sperm DNA are remodeled to an embryonic pattern. A recent study examining global methylation of repetitive elements in various mammals showed that the reprogramming that occurs during normal preimplantation development is aberrant in cloned embryos.
authors.affiliation: Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. bartolom@mail.med.upenn.edu
authors.forename: Mellissa R W
authors.initials: MR
authors.lastname: Mann
authors.forename: Marisa S
authors.initials: MS
authors.lastname: Bartolomei
mesh_terms: D000818:Animals; D019976:Cloning, Organism; D019175:DNA Methylation; D004622:Embryo, Mammalian / Q000737:chemistry* / Q000378:metabolism*; D004625:Embryo, Nonmammalian; D047108:Embryonic Development / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D018392:Genomic Imprinting / Q000235:genetics*; D020071:Interspersed Repetitive Sequences / Q000235:genetics; D011247:Pregnancy
chemical_list: D005819:Genetic Markers