[The effect of fluoride-arsenic exposure on the lipid peroxidation and antioxidation of the offspring of rats].
OBJECTIVE
To provide information on the effects of the offspring of rats exposed to fluoride-arsenic.


METHODS
The levels of lipid peroxidation and the abilities of antioxidation were determined in the blood of the rats and their offsprings under two generations-one nest reproductive test.


RESULTS
The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the blood decreased with the increase of exposure dose. For example, the activity of SOD, was 14.56, 13.74, 11.89 and 11.21 micromol x min(-1) x mg Hb(-1) in different dose groups of F(2), respectively. In contrast, the concentration of lipid peroxides (LPO) increased. Eight weeks after exposure, the activities of SOD and GSH-Px increased, the activity of SOD was 13.97, 13.55, 13.47 and 12.76 micromol x min(-1) x mg Hb(-1), respectively, and the concentration of LPO returned to normal level.


CONCLUSIONS
Fluoride-arsenic exposure can cause oxidative damage of the rat's offspring.
Zhang
C
C
School of Public Health, Xinjiang Medical University, Urumqi 830054, China.
Liu
J
J
Ling
B
B
Song
X
X
Gu
W
W
Wang
G
G
D000818:Animals; D000077237:Arsenic Trioxide; D001152:Arsenicals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D010087:Oxides / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012969:Sodium Fluoride / Q000633:toxicity*; D013482:Superoxide Dismutase / Q000378:metabolism*
D001152:Arsenicals; D008054:Lipid Peroxides; D010087:Oxides; D012969:Sodium Fluoride; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000077237:Arsenic Trioxide