title: Pharmacology at the beginning of the 21st century: implications of several new developments for dentistry and current status of the major 20th century dental drugs.
abstract: This review has highlighted some of the developments in pharmacology likely to impact dentistry as we enter the 21st century. While dentistry will naturally lag behind medicine in the introduction of new drugs, we must constantly explore all information resources available to keep abreast of developments in pharmacology that will affect our patients and our use of drugs in dental practice. This century will abound with new therapies, some of which will hopefully lead us out of our tradition of using rather non-selective, widely distributed chemicals with multiple actions and side effects into an age of highly-selective therapies, including the repair and replacement of defective genetic determinants of disease with healthy ones.
authors.affiliation: Department of Basic Sciences, University of Texas-Houston Dental Branch, Houston, Texas, USA.
authors.forename: A H
authors.initials: AH
authors.lastname: Jeske
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000145:classification; D003813:Dentistry / Q000639:trends*; D016503:Drug Delivery Systems; D015195:Drug Design; D004351:Drug Resistance; D004358:Drug Therapy / Q000639:trends*; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008565:Membrane Proteins; D010146:Pain / Q000503:physiopathology; D010544:Peroxidases / Q000037:antagonists & inhibitors; D010600:Pharmacology / Q000639:trends*; D011451:Prostaglandin-Endoperoxide Synthases
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D003577:Cytochrome P-450 Enzyme System; D010544:Peroxidases; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases