Reversal of pyrogallol-induced delay in gastric emptying in rats by ginger (Zingiber officinale).
The effects of the acetone extract of ginger (Zingiber officinale) was studied against pyrogallol-induced delay in gastric emptying in rats. Wistar rats of either sex, weighing between 200-250 g, were used. Pyrogallol, at a dose of 100 mg/kg i.p., significantly delayed the gastric emptying of a methyl cellulose meal. One-hour pretreatment with ginger acetone extracts (100, 250 and 500 mg/kg p.o.) reversed the pyrogallol-induced delay in gastric emptying. The effect was significant at doses of 250 and 500 mg/kg. When the low dose of ginger (100 mg/kg p.o.) was given with vitamin C and vitamin E (100 mg/kg p.o., each), the reversal of gastric emptying was more pronounced than when only two vitamins or ginger (100 mg/kg and 500 mg/kg) were given alone. The present study indicates the potential of ginger in improving symptoms such as abdominal discomfort and bloating, which may accompany several gastrointestinal illnesses.
Gupta
Y K
YK
Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India. ykg@hotmail.com
Sharma
M
M
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D005260:Female; D005609:Free Radicals; D005746:Gastric Emptying / Q000187:drug effects*; D020939:Zingiber officinale; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011748:Pyrogallol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000494:pharmacology
D005609:Free Radicals; D010936:Plant Extracts; D011748:Pyrogallol; D014810:Vitamin E; D001205:Ascorbic Acid