Effect of oral OPC-28326, a selective femoral arterial vasodilator, on hindlimb subcutaneous tissue temperature in conscious dogs under buprenorphine sedation.
In dogs, rectal temperature was decreased to about 36 degrees C at 2 to 2.5 h after sedation with buprenorphine (0.3 mg/body, i.m.), and hindlimb subcutaneous tissue temperature (T(SC)) in the thigh decreased in a similar manner. T(SC) in the dorsum of the foot showed a greater decrease than that in the thigh. OPC-28326 (4-(N-methyl-2-phenylethylamino)-1-(3,5-dimethyl-4-propionyl-aminobenzoyl) piperidine hydrochloride monohydrate) at doses of 0.3, 1.0 and 3.0 mg/kg, p.o. inhibited the buprenorphine-induced decrease in T(SC) in the dorsum dose-dependently, but had little effect on that in the thigh or rectal temperature. In conclusion, T(SC) in the extremities were more sensitive to core temperature and peripheral circulation.
Orito
Kensuke
K
Second Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd., Japan.
Imaizumi
Takashi
T
Yoshida
Kenji
K
Kishi
Masami
M
Fujiki
Hiroyuki
H
Mori
Toyoki
T
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology; D000814:Aniline Compounds / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects*; D002047:Buprenorphine / Q000008:administration & dosage / Q000494:pharmacology*; D003243:Consciousness; D004285:Dogs; D005263:Femoral Artery / Q000187:drug effects* / Q000502:physiology; D006614:Hindlimb / Q000098:blood supply / Q000187:drug effects*; D008297:Male; D010880:Piperidines / Q000008:administration & dosage* / Q000494:pharmacology*; D012007:Rectum / Q000187:drug effects / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects; D013848:Thigh / Q000502:physiology; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
D000701:Analgesics, Opioid; D000814:Aniline Compounds; D010880:Piperidines; D014665:Vasodilator Agents; D002047:Buprenorphine; C400276:OPC 28326