Behavior of alginate gel beads containing chitosan salt prepared with water-soluble vitamins.
Alginate gel beads were prepared which contained weak acid salts of chitosan (Alg-CS) and water-soluble vitamins (e.g. ascorbic acid (AS)) and the behavior of the beads, uptake of bile acids was investigated in vitro. The Alg-CS beads rapidly took up bile acid and this phenomenon was observed for both hydrogel beads and dried beads. About 120 micromol of taurocholic acid was taken up into Alg-CS (1 g) prepared with orotic acid. Dried Alg-CS is the granule which can be made easily, and keeps the ability of CS salt, and all elements can be taken as a food. Therefore, Alg-CS could serve as a useful dietary agent for the prevention of hyperlipidemia.
Murata
Yoshifumi
Y
Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa, Japan. y-murata@hokuriku-u.ac.jp
Kontani
Yukari
Y
Ohmae
Hiroko
H
Kawashima
Susumu
S
D000464:Alginates / Q000493:pharmacokinetics*; D001647:Bile Acids and Salts / Q000493:pharmacokinetics; D001672:Biocompatible Materials / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical; D002686:Chitin / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D048271:Chitosan; D019343:Citric Acid / Q000493:pharmacokinetics; D005492:Folic Acid / Q000493:pharmacokinetics; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008863:Microspheres; D009963:Orotic Acid / Q000493:pharmacokinetics; D012995:Solubility; D014815:Vitamins / Q000493:pharmacokinetics*
D000464:Alginates; D001647:Bile Acids and Salts; D001672:Biocompatible Materials; D006603:Hexuronic Acids; D014815:Vitamins; D002686:Chitin; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D019343:Citric Acid; D009963:Orotic Acid; D020723:Glucuronic Acid; D048271:Chitosan; D005492:Folic Acid