Changes of comedonal cytokines and sebum secretion after UV irradiation in acne patients.
The aims of this study were to investigate the effect of UVA and UVB on comedones and sebum secretion in acne patients. Thirteen acne patients were irradiated by UVA (starting from 20J/cm2 and increasing 10% every day) and UVB (starting from 2/3 MED and increasing 10% every day). IL-1alpha, IL-6, IL-1 receptor antagonist (IL-1ra), IL-10 and GM-CSF were measured by ELISA. Measurement of sebum level was also performed. Sebum level was increased in the first three days by UVA (18.4 --> 37.6 microg/cm2) and UVB (19.1 --> 40.0 microg/cm2), but subsequently returned to normal values. Production of IL-1alpha, IL-1ra, IL-6, and IL-10 was generally higher on day 5 than on day 10. GM-CSF was not detected from all comedones. After UV irradiation, clinically stationary acne patients showed a higher increase in cytokine production compared with improved acne patients. It is suggested that IL-10 & IL-1ra have key roles in this cytokine network as the anti-inflammatory comedonal cytokines. They may play important roles in the immuno-regulation, which may be disturbed in stationary acne patients.
Suh
Dae Hun
DH
Department of Dermatology, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Korea.
Kwon
Tae Eun
TE
Youn
Jai Il
JI
D000152:Acne Vulgaris / Q000276:immunology / Q000378:metabolism / Q000532:radiotherapy*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000378:metabolism*; D016753:Interleukin-10 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D015603:Keratinocytes / Q000528:radiation effects*; D008297:Male; D012627:Sebaceous Glands / Q000378:metabolism / Q000528:radiation effects*; D012629:Sebum / Q000378:metabolism*; D012795:Sialoglycoproteins / Q000378:metabolism; D014467:Ultraviolet Therapy
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D015850:Interleukin-6; D012795:Sialoglycoproteins; D016753:Interleukin-10