Ethical issues in HIV vaccine trials in South Africa.
In this review we describe the ethical issues central to local and international debates about HIV vaccine trials. These issues include the physiological and psycho-social risks of trial participation, the preventative interventions to be provided to participants, access to treatment for participants who seroconvert, access to an effective vaccine after the trial, the role of placebo-controlled trials, and obtaining informed consent.
Slack
C
C
School of Psychology, University of Natal, Private Bag X01, Scottsville, 3209 South Africa.
Lindegger
G
G
Vardas
E
E
Richter
L
L
Strode
A
A
Wassenaar
D
D
D016915:AIDS Vaccines; D002986:Clinical Trials as Topic / Q000592:standards*; D032781:Codes of Ethics; D003466:Cultural Characteristics; D017408:Guidelines as Topic; D015658:HIV Infections; D006297:Health Services Accessibility; D006805:Human Experimentation; D006806:Human Rights; D006801:Humans; D007258:Informed Consent; D038622:Internationality; D010919:Placebos; D035842:Research Subjects; D018570:Risk Assessment; D013019:South Africa
D016915:AIDS Vaccines; D010919:Placebos