Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats.
Previously we reported the construction of a congenic strain, S.LEW, spanning a large region of rat chromosome 5. The Lewis (LEW) strain was the donor, and the Dahl salt-sensitive (S) strain was the recipient. The congenic strain included a blood pressure quantitative trait locus (QTL). In the present work, a series of nine congenic substrains were constructed from S.LEW which defined two closely linked blood pressure QTL in the region previously thought to contain only one. LEW low-blood-pressure alleles at both QTL were required for a major effect on blood pressure. Neither LEW allele alone had a significant effect on blood pressure. The two QTL were localized to regions 6.3 and 4.6 cM, and these were 1.0 cM apart.
Garrett
Michael R
MR
Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614-5804, USA.
Rapp
John P
JP
D000483:Alleles; D000818:Animals; D020296:Animals, Congenic; D001794:Blood Pressure / Q000235:genetics*; D001947:Breeding / Q000379:methods; D002874:Chromosome Mapping / Q000379:methods; D003433:Crosses, Genetic; D008040:Genetic Linkage / Q000235:genetics*; D008297:Male; D019655:Quantitative Trait, Heritable; D051381:Rats; D020303:Rats, Inbred Dahl; D011917:Rats, Inbred Lew