title: Genes, pseudogenes, and Alu sequence organization across human chromosomes 21 and 22.
abstract: Human chromosomes 21 and 22 (mainly the q-arms) were the first complete parts of the human genome released. Our analysis of genes, pseudogenes (Psig), and Alu repeats across these chromosomes include the following findings: The number of gene structures containing untranslated exons exceeds 25%; the terminal exon tends to be the largest among exons, whereas, the initial intron tends to be the largest among introns; single-exon gene length is approximately the mean gene exon number times the mean internal exon length; processed Psig lengths are on average approximately the same as single-exon gene length; and the G+C content and length of genes are uncorrelated. The counts and distribution of genes, Psig, and Alu sequences and G+C variation are evaluated with respect to clusters and overdispersions. Other assessments concern comparisons of intergenic lengths, properties of Psig sequences, and correlations between Alu and Psig sequences.
authors.affiliation: Department of Mathematics, Stanford University, Stanford, CA 94305-2125, USA.
authors.forename: Chingfer
authors.initials: C
authors.lastname: Chen
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Gentles
authors.forename: Jerzy
authors.initials: J
authors.lastname: Jurka
authors.forename: Samuel
authors.initials: S
authors.lastname: Karlin
mesh_terms: D020087:Alu Elements; D002891:Chromosomes, Human, Pair 21; D002892:Chromosomes, Human, Pair 22; D021901:DNA, Intergenic; D005091:Exons; D005796:Genes; D006801:Humans; D007438:Introns; D014176:Protein Biosynthesis; D011544:Pseudogenes
chemical_list: D021901:DNA, Intergenic