The alpha(v)beta3 integrin, NF-kappaB, osteoprotegerin endothelial cell survival pathway. Potential role in angiogenesis.
The growth and survival of many cell types requires integrin-mediated adhesion to the extracellular matrix (ECM). Physiologically, the prerequisite of cell-ECM adhesion interaction for cell cycle progression and cell survival is likely to be important in tissue morphology and regression as a mechanism to regulate tissue architecture and cell number. Pathologically, anchorage-dependent survival may limit tumor invasion and metastasis. Endothelial cells are anchorage-dependent cells, and many ECM molecules interacting with different classes of integrins promote their survival. It has became clear, however, that during the angiogenesis process the alpha(v)beta(3) integrin plays a fundamental role in maintaining endothelial cell viability. The downstream signals regulating this process are becoming clarified, and new functions are described for molecules involved in apparently distant systems.
Scatena
Marta
M
Department of Bioengineering, University of Washington, Seattle, WA 98195-1720, USA.
Giachelli
Cecilia
C
D000818:Animals; D002642:Chick Embryo; D005109:Extracellular Matrix / Q000502:physiology*; D006023:Glycoproteins / Q000502:physiology; D006801:Humans; D051379:Mice; D016328:NF-kappa B / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology*; D053244:Osteoprotegerin; D011817:Rabbits; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor; D019030:Receptors, Vitronectin / Q000502:physiology*
D006023:Glycoproteins; D016328:NF-kappa B; D053244:Osteoprotegerin; D018160:Receptors, Cytoplasmic and Nuclear; D018124:Receptors, Tumor Necrosis Factor; D019030:Receptors, Vitronectin; C506030:TNFRSF11B protein, human; C506031:Tnfrsf11b protein, mouse; C506032:Tnfrsf11b protein, rat