title: [Synthesis and antibacterial activity of the new 9-aminoacridine, 10,11-dihydro-5H-dibenzo[b,f]azepine, polyfluoro 5,6-dihydro-1,3,5-oxadiazine derivatives].
abstract: Screening among 9-aminoacridine, 10,11-dihydro-5H-dibenz[b, f]azepine and polyfluoro 5,6-dihydro-1,3,5-oxadiazine derivatives allowed to isolate compounds with potential antibacterial activity. Schemes of the active compounds synthesis are given. The most important is the estimation of the oxydiazines activity against gram-positive microorganisms including methicillin-resistant staphylococci. Special attention is paid to the activity of iminodibenzyl derivatives against multiresistant gram-negative microorganisms.
authors.affiliation: Center of Medical, Biological and Ecological Problems, Russian Academy of Natural Sciences, National Research Centre of Antibiotics, Moscow.
authors.forename: I N
authors.initials: IN
authors.lastname: Torgun
authors.forename: S V
authors.initials: SV
authors.lastname: Sydorenko
authors.forename: I E
authors.initials: IE
authors.lastname: Zykova
authors.forename: S M
authors.initials: SM
authors.lastname: Iudin
authors.forename: L I
authors.initials: LI
authors.lastname: Kriukova
authors.forename: I I
authors.initials: II
authors.lastname: Krylov
authors.forename: L N
authors.initials: LN
authors.lastname: Kriukov
authors.forename: S L
authors.initials: SL
authors.lastname: Kuznotsov
authors.forename: E A
authors.initials: EA
authors.lastname: Vorontsov
authors.forename: S P
authors.initials: SP
authors.lastname: Rezvan
authors.forename: S A
authors.initials: SA
authors.lastname: Grudinina
mesh_terms: D000585:Aminacrine / Q000737:chemistry / Q000494:pharmacology; D000609:Aminoacridines / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001381:Azepines / Q000737:chemistry; D001671:Biochemistry / Q000379:methods; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006094:Gram-Positive Bacteria / Q000187:drug effects; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010078:Oxazines / Q000737:chemistry; D013210:Staphylococcus / Q000187:drug effects / Q000502:physiology
chemical_list: C453540:9-ethyltrifluoromethylmalonylamidoacridine; D000609:Aminoacridines; D000900:Anti-Bacterial Agents; D001381:Azepines; D010078:Oxazines; D000585:Aminacrine