Amniotic fluid soluble human leukocyte antigen G is markedly decreased in offspring with neural tube defects.
Pregnancies affected by a neural tube defect show changes in thymus morphology, neonatal and maternal T-cell repertoire. Amniotic fluid levels of soluble human leukocyte antigen G (HLA-G) (an immuno-modulatory protein) were found to be significantly lower as compared to controls. This may reflect a diminished cell-mediated immunity in neural tube defects.
Emmer
Peter M
PM
Department of Bloodtransfusion and Transplantation Immunology, University Medical Center Nijmegen, Geert Grooteplein 10, PO Box 9101, 6500 HB, huispost 603/ABTI, Nijmegen, The Netherlands.
Steegers
Eric A P
EA
van Lierop
Marié Jose
MJ
Steegers-Theunissen
Régine P M
RP
Loke
Yung Way
YW
Joosten
Irma
I
D000649:Amniocentesis; D000653:Amniotic Fluid / Q000737:chemistry / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000096:biosynthesis*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D009436:Neural Tube Defects / Q000276:immunology* / Q000378:metabolism; D011247:Pregnancy
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I