title: [Hemodynamic tolerance and rapid hypertrophy of a hepatic graft corresponding to less than 30% of the ideal mass in pigs].
abstract: OBJECTIVE
  Evaluation of a new pig liver transplantation technique for survival and hypertrophy of a small-sized graft by providing adapted and controlled venous portal flow.
  
  
  METHODS
  [corrected] Twenty Large-White pigs underwent heterotopic liver transplantation after a mesocaval shunt and ligation of the superior mesenteric vein downstream from the shunt. The donor-to-recipient weight ratio was below 30%. Furthermore, recipient's biliary duct and portal vein into the hilum were tied. In a control group, no mesocaval shunt was performed and the graft received the entire splanchnic venous flow.
  
  
  RESULTS
  The mesocaval shunt provided diversion of 60% of the splanchnic blood flow. The median survival of study pigs was 39 days (range: 8-98). Median serum bilirubin levels at 1 week were 12 micromol/L (range: 4-59). At autopsy, graft weight was increased to 2.7 times the initial weight and histological findings were normal. In the control group, all pigs died quickly from acute splanchnic congestion.
  
  
  CONCLUSIONS
  In a model of heterotopic liver transplantation using small-sized grafts, complete diversion of mesenteric blood flow through a mesocaval shunt resulted in hemodynamic tolerance and hypertrophy of a graft corresponding to less than 30% of the ideal mass.
authors.affiliation: Faculté Laennec, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Pouyet
authors.forename: C
authors.initials: C
authors.lastname: Paquet
authors.forename: I
authors.initials: I
authors.lastname: Mechet
authors.forename: Y
authors.initials: Y
authors.lastname: Le Derf
authors.forename: P
authors.initials: P
authors.lastname: Bernard
authors.forename: P
authors.initials: P
authors.lastname: Figueiredo
authors.forename: F
authors.initials: F
authors.lastname: Berger
authors.forename: O
authors.initials: O
authors.lastname: Boillot
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001652:Bile Ducts; D001663:Bilirubin / Q000097:blood; D003250:Constriction; D006439:Hemodynamics; D006984:Hypertrophy; D008026:Ligation; D008099:Liver / Q000473:pathology*; D016031:Liver Transplantation / Q000379:methods*; D008642:Mesenteric Veins / Q000601:surgery; D023421:Models, Animal; D009929:Organ Size; D011169:Portal Vein / Q000601:surgery; D013152:Splanchnic Circulation; D013552:Swine; D016042:Transplantation, Heterotopic
chemical_list: D001663:Bilirubin