title: [Occupational airway sensitization due to subtilisin].
abstract: Since the 1960s an increasing number of occupational allergies against natural, and against modified recombinant enzymes were observed. Subtilisin, a frequently used enzyme often has been shown to cause airway sensitization. The present evaluation of clinical literature data confirms the sensitization potential of subtilisin. Several cases of specific airway hyperresponsiveness caused by subtilisin are verified by a number of studies. As symptoms, results of skin prick tests, detection of specific IgE-antibodies and results of specific bronchoprovocation tests are consistent, an immunologic mechanism is confirmed.
authors.affiliation: Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, BGFA, Bochum, Germany. kampen@bgfa.de
authors.forename: V
authors.initials: V
authors.lastname: van Kampen
authors.forename: R
authors.initials: R
authors.lastname: Merget
mesh_terms: D016535:Bronchial Hyperreactivity / Q000139:chemically induced; D001985:Bronchial Provocation Tests; D004342:Drug Hypersensitivity / Q000209:etiology / Q000276:immunology*; D006801:Humans; D009784:Occupational Diseases / Q000209:etiology* / Q000276:immunology*; D016273:Occupational Exposure; D020860:Subtilisin / Q000009:adverse effects* / Q000276:immunology
chemical_list: D020860:Subtilisin