[A pathological study of lens subcapsular epithelial proliferation].
OBJECTIVE
To observe the histopathological changes of lens subcapsular epithelial proliferation and analyze their etiology.


METHODS
Sixty-four enucleated eyes with lens subcapsular epithelial proliferation were observed with light microscopy and analyzed retrospectively. Among all the cases of lens subcapsular epithelial proliferation, there were 36 ones enucleated because of trauma, 10 absolute glaucoma, 6 corneoscleral staphyloma, 5 intraocular tumor, 2 after cataract extraction, 4 endophthalmitis, 1 cataract combined with ocular atrophy (diabetes type II).


RESULTS
Proliferated lens subcapsular epithelial cells were atypical, irregularly arranged, and extended to the posterior subcapsule. In cases with lens capsular rupture or partial absence, there were subcapsular fibro-connective tissue metaplasia, scar tissue formation, cortical collapse, local liquefaction and calcification.


CONCLUSIONS
Lens subcapsular epithelial proliferation is caused by some intraocular pathological conditions. In cases with endophthalmitis and ocular trauma, its severity is the most serious.
Zhao
G
G
Department of Ophthalmology, Affiliated Hospital, Medical College of Qingdao University, Qingdao 266003, China.
Sun
W
W
Niu
Y
Y
Wang
C
C
Liu
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002455:Cell Division / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D004847:Epithelial Cells / Q000473:pathology*; D005128:Eye Diseases / Q000503:physiopathology; D005131:Eye Injuries / Q000503:physiopathology; D005260:Female; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies