title: Transdermal delivery of triprolidine using TPX polymer membrane.
abstract: Triprolidine-containing matrix was fabricated with poly(4-methyl-1-pentene) (TPX) polymer to control the release of the drug. Effect of penetration enhancer and stripping of skin on the permeation of triprolidine through the excised mouse skin was studied. Penetrating enhancers showed the increased flux probably due to the enhancing effect on the skin barrier, the stratum corneum. Among enhancers used such as glycols, fatty acids and non-ionic surfactants, polyoxyethylene-2-oleyl ether showed the best enhancement. The permeability of triprolidine was markedly increased with stripping the mouse skin to remove the stratum corneum, which acts as a barrier of skin permeation. For the controlling delivery of triprolidine, the TPX matrix containing permeation enhancer could be developed.
authors.affiliation: College of Pharmacy, Chonnam National University, 300 Yongbongdong, Bukku, 500-757, Kwangju, South Korea. shinsc@chonnam.chonnam.ac.kr
authors.forename: Sang-Chul
authors.initials: SC
authors.lastname: Shin
authors.forename: Jin
authors.initials: J
authors.lastname: Kim
authors.forename: Mi-Kyoung
authors.initials: MK
authors.lastname: Yoon
authors.forename: In-Joon
authors.initials: IJ
authors.lastname: Oh
authors.forename: Jun-Shik
authors.initials: JS
authors.lastname: Choi
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D008297:Male; D008567:Membranes, Artificial; D051379:Mice; D008813:Mice, Inbred ICR; D011090:Polyenes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011108:Polymers / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology; D014311:Triprolidine / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D018926:Anti-Allergic Agents; D008567:Membranes, Artificial; D011090:Polyenes; D011108:Polymers; C087577:poly(4-methyl-1-pentene); D014311:Triprolidine