title: Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I.
abstract: Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis I, prove to encode subunits of the anaphase-promoting complex or cyclosome (APC/C). RNA interference studies reveal that these and other APC/C subunits are essential for the segregation of chromosomal homologs during meiosis I. Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion.
authors.affiliation: Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0840, USA.
authors.forename: Edward S
authors.initials: ES
authors.lastname: Davis
authors.forename: Lucia
authors.initials: L
authors.lastname: Wille
authors.forename: Barry A
authors.initials: BA
authors.lastname: Chestnut
authors.forename: Penny L
authors.initials: PL
authors.lastname: Sadler
authors.forename: Diane C
authors.initials: DC
authors.lastname: Shakes
authors.forename: Andy
authors.initials: A
authors.lastname: Golden
mesh_terms: D000595:Amino Acid Sequence; D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D020090:Chromosome Segregation / Q000502:physiology; D004252:DNA Mutational Analysis; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology; D008025:Ligases / Q000235:genetics* / Q000502:physiology; D008540:Meiosis / Q000502:physiology*; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D010750:Phosphoproteins; D021122:Protein Subunits; D012330:RNA, Double-Stranded / Q000235:genetics / Q000502:physiology; D029702:Schizosaccharomyces pombe Proteins; D016415:Sequence Alignment; D013489:Suppression, Genetic / Q000235:genetics / Q000502:physiology; D043743:Ubiquitin-Protein Ligase Complexes; D000097722:Cohesins
chemical_list: D064173:Anaphase-Promoting Complex-Cyclosome; D005656:Fungal Proteins; D008025:Ligases; D010750:Phosphoproteins; D021122:Protein Subunits; D012330:RNA, Double-Stranded; D029702:Schizosaccharomyces pombe Proteins; D043743:Ubiquitin-Protein Ligase Complexes; C077081:REC8 protein, S pombe; D000097722:Cohesins