Blood platelet membrane fluidity and the exposition of membrane protein receptors in Alzheimer disease (AD) patients--preliminary Study.
We estimated membrane fluidity by the (ESR) spectroscopy and the expression of membrane P-selectin and glycoproteins GP Ib alpha and GP IIb/IIIa by flow cytometry in platelets (plts) from 12 AD sufferers. In AD patients membrane fluidity was significantly increased at two different depths (p < 0.05 or less). Platelet reactivity was significantly decreased, as reflected by reduced expression of GP Ib alpha in the resting (p < 0.0001) and activated (p < 0.005) platelets, as well as the expression of P-selectin and beta 3 subunit of GP IIb/IIIa in activated platelets (p < 0.0001; p < 0.04).
Kozubski
Wojciech
W
Department of Neurology, University of Medical Sciences, Poznan, Poland.
Swiderek
Mariola
M
Kloszewska
Iwona
I
Gwozdzinski
Krzysztof
K
Watala
Cezary
C
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood*; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D008297:Male; D008560:Membrane Fluidity / Q000502:physiology*; D019007:P-Selectin / Q000097:blood*; D015539:Platelet Activation / Q000502:physiology; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism*; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000378:metabolism*; D012016:Reference Values
D019007:P-Selectin; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex