[Mycobacterial spindle cell pseudotumor of lymph nodes].
OBJECTIVE
To study the clinicopathological of mycobacterial spindle cell pseudotumor in lymph nodes.


METHODS
Two cases of spindle cell pseudotumor in the lymph nodes of infants were examined using light microscopy. The sections were stained with HE, Ziehl-Neelsen and studied immunohistochemically.


RESULTS
Both infants were 1 year of age and had a history of Bacilli Calmette Guerin (BCG) vaccination before discovery of their lymph node lesions. Clinically, the patients presented fever and enlarged lymph nodes. Histopathologically, the lesions showed proliferation of spindle cells arranged in bundles, storiform patterns with abundant capillaries and lymphocyte, plasma cell and neutrophil infiltration forming a spindle cell pseudotumor. Most of the spindle cells were phagocytic cells which contained large amounts of mycobactrium as observed by Ziehl-Neelsen staining. Immunohistochemical staining showed strongly positive result for Mac387 and lysosome, but negative for S-100 in spindle cells and histocytes.


CONCLUSIONS
Mycobacterial spindle cell pseudotumor of lymph nodes may occur not only in immunodeficient patients (such as AIDS) but also in infants after BCG vaccination. The lesions may mimic spindle cell tumor in lymph nodes, therefore it is very important to recognize these lesions in order to treat the patient properly.
Yin
H
H
Department of Pathology, Nanjing General Hospital of PLA, Nanjing 210002, China. yinhl@jlonline.com
Zhou
X
X
Meng
K
K
Sun
Y
Y
D001500:BCG Vaccine / Q000009:adverse effects*; D003937:Diagnosis, Differential; D006104:Granuloma, Plasma Cell / Q000473:pathology; D006801:Humans; D007223:Infant; D008198:Lymph Nodes / Q000382:microbiology / Q000473:pathology*; D008206:Lymphatic Diseases / Q000382:microbiology / Q000473:pathology*; D008297:Male; D009164:Mycobacterium Infections / Q000473:pathology; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D012514:Sarcoma, Kaposi / Q000473:pathology; D014388:Tuberculosis, Lymph Node / Q000473:pathology
D001500:BCG Vaccine