title: Neural plate patterning by secreted signals.
abstract: The patterning of the CNS relies on the interaction of multiple signaling molecules such as Sonic Hedgehog, Wnts, and BMPs and their antagonists Chordin and Noggin. The identification of the secreted molecule Tiarin (Tsuda et al., 2002, this issue of Neuron), produced by the nonneural ectoderm at border of the anterior and lateral neural plate, now introduces a novel signaling pathway participating in CNS development.
authors.affiliation: Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA.
authors.forename: Oliver
authors.initials: O
authors.lastname: Wessely
authors.forename: E M
authors.initials: EM
authors.lastname: De Robertis
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D002490:Central Nervous System / Q000166:cytology / Q000378:metabolism*; D004627:Embryonic Induction / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006133:Growth Substances / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D006133:Growth Substances