title: [Study on clinical and laboratory features of preleukemia patients].
abstract: OBJECTIVE
  To explore prospective diagnostic criteria for preleukemia.
  
  
  METHODS
  A case control study of the discrepancies of clinical and laboratory features between patients with preleukemia and those with chronic aplastic anemia (CAA) or atypical paroxysmal nocturnal hemoglubinuria (a-PNH).
  
  
  RESULTS
  There were eight variables of significance: (1) lymphocytoid micromegakaryocytes in marrow; (2) immature granulocytes in peripheral blood; (3) >or= 2% myeloblasts in marrow; (4) positive periodic acid schiff (PAS) staining of nucleated erythrocytes; (5) myeloid differentiation index >or= 1.8; (6) clonal karyotypic abnormalities; (7) negative sister chromatid differentiation; (8) > 4.0 cluster/colony ratio of granulocyte-macrophage colony-forming units (CFU-GM). The following criteria was assigned: A: To meet (1) and at least two of the other seven variables; B: To meet at least four of the eight variables. All of the patients with preleukemia met A or B and none of the patients with CAA or a-PNH did.
  
  
  CONCLUSIONS
  Preleukemia is different from CAA or a-PNH. It has its own clinical and laboratory features, which may be useful for prospective diagnosis.
authors.affiliation: Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Shao
authors.forename: J
authors.initials: J
authors.lastname: Shi
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: K
authors.initials: K
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Zheng
authors.forename: H
authors.initials: H
authors.lastname: He
authors.forename: M
authors.initials: M
authors.lastname: Zhao
authors.forename: G
authors.initials: G
authors.lastname: He
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Chu
authors.forename: Y
authors.initials: Y
authors.lastname: Hao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017209:Apoptosis; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D011289:Preleukemia / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D012189:Retrospective Studies