title: Seizure semiology and neuroimaging findings in patients with midline spikes.
abstract: OBJECTIVE
  Midline epileptiform discharges are rare compared with discharges at other scalp locations. Neuroimaging results and semiologic seizure characteristics of patients with midline spikes are not adequately described. The aim of this study was to describe the neuroimaging findings and detailed seizure semiologies in patients with midline spikes.
  
  
  METHODS
  We reviewed the EEG database of the University of Michigan Medical Center and identified 35 patients with midline spikes. Information about seizure types and neuroimaging results was obtained from a review of medical records. The seizures were classified according to the International League Against Epilepsy (ILAE) criteria and semiologic classification.
  
  
  RESULTS
  Twenty-nine (83%) patients had a history of seizures. Complex partial seizures and simple partial seizures were the most common seizure types, experienced by 66% of patients. The age at seizure onset was within the first 10 years in 90% of patients. According to the semiologic seizure classification, automotor seizures and tonic seizures were the most common seizure types. Neuroimaging studies were abnormal in 45% of patients. When focal abnormalities were detected, they were lateralized to one of the frontal lobes in all cases.
  
  
  CONCLUSIONS
  Our results indicate that in the majority of patients, midline spikes represent focal epileptiform activity rather than fragments of generalized discharges, and are most commonly associated with seizures of partial onset. Automotor seizures and tonic seizures are the most common semiologies. Focal radiologic abnormalities tend to be lateralized to one of the frontal lobes.
authors.affiliation: Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: E
authors.initials: E
authors.lastname: Kutluay
authors.forename: E A
authors.initials: EA
authors.lastname: Passaro
authors.forename: D
authors.initials: D
authors.lastname: Gomez-Hassan
authors.forename: A
authors.initials: A
authors.lastname: Beydoun
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000706:statistics & numerical data; D004828:Epilepsies, Partial / Q000145:classification / Q000175:diagnosis; D004827:Epilepsy / Q000145:classification / Q000175:diagnosis*; D017034:Epilepsy, Frontal Lobe / Q000145:classification / Q000175:diagnosis; D004829:Epilepsy, Generalized / Q000145:classification / Q000175:diagnosis; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data