title: D-Secoestrone derivatives. VI. 17 beta-Benzyl-17 alpha-hydroxy-3-methoxyestra-1,3,5(10)-trien-16-one.
abstract: The title molecule, C(26)H(30)O(3), shows a novel chemical rearrangement of the substituents at position 17, i.e. an alpha-orientation of the hydroxy group and a beta-orientation of the bulky benzyl moiety. The packing arrangement consists of coils formed by O(2)...O(3) hydrogen bonds along the c axis. The compound shows complete loss of oestrogenic activity, and neither does it exhibit an antagonistic effect.
authors.affiliation: Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradoviá 4, 21000 Novi Sad, Yugoslavia. cica@uns.ns.ac.yu
authors.forename: Slobodanka
authors.initials: S
authors.lastname: Stanković
authors.forename: Dusan
authors.initials: D
authors.lastname: Lazar
authors.forename: Ljubica
authors.initials: L
authors.lastname: Medić-Mijacević
authors.forename: Katarina
authors.initials: K
authors.lastname: Penov-Gasi
authors.forename: Marija
authors.initials: M
authors.lastname: Sakac
authors.forename: Silvana
authors.initials: S
authors.lastname: Andrić
authors.forename: Bruvo
authors.initials: B
authors.lastname: Milenko
mesh_terms: D045166:Estradiol Congeners / Q000737:chemistry*; D004970:Estrone / Q000031:analogs & derivatives / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: C455528:17-benzyl-17-hydroxy-3-methoxyestra-1,3,5(10)-trien-16-one; D045166:Estradiol Congeners; D004970:Estrone