title: Gallbladder metastasis of renal cell carcinoma: report of two cases.
abstract: We report two extremely rare cases of metastasis to the gallbladder from renal cell carcinoma. In both men, aged 63 and 80 years, a pedunculated polypoid gallbladder tumor was incidentally found 27 and 8 years after surgery for renal cell carcinoma, respectively. The tumors showed hypervascularity on diagnostic imaging. A histopathological examination showed no tumor cells in the gallbladder mucosa. but clear cell carcinoma was predominantly observed below the mucosal layer. Furthermore, based on various specific and immunohistochemical studies as well as the electronmicroscopic findings, the patients were pathologically diagnosed to have gallbladder metastasis of renal cell carcinoma.
authors.affiliation: Department of Surgery, Tokyo Medical University, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Aoki
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Inoue
authors.forename: Akihiko
authors.initials: A
authors.lastname: Tsuchida
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Aoki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kasuya
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kitamura
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Koyanagi
authors.forename: Tohru
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000556:secondary*; D005704:Gallbladder / Q000473:pathology; D005706:Gallbladder Neoplasms / Q000556:secondary*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors