title: Reactivation of herpes simplex virus keratitis after initiating bimatoprost treatment for glaucoma.
abstract: OBJECTIVE
  To report a case of herpes simplex virus reactivation after starting bimatoprost treatment for glaucoma.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  A 66-year-old woman had a herpes simplex keratouveitis reactivation that occurred within 1 month after starting bimatoprost. The herpes simplex had been inactive for more than 10 years.
  
  
  RESULTS
  Bimatoprost and prednisolone acetate 0.12% were discontinued; oral acyclovir, ofloxacin, and betaxolol 0.25% were initiated. Two weeks later, prednisolone acetate 1% was added. The reactivation resolved, and 1 month later, the best corrected visual acuity improved to 20/40.
  
  
  CONCLUSIONS
  Caution should be used in prescribing bimatoprost for patients with a history of herpes simplex virus keratitis.
authors.affiliation: New England Eye Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
authors.forename: Debra M
authors.initials: DM
authors.lastname: Kroll
authors.forename: Joel S
authors.initials: JS
authors.lastname: Schuman
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000368:Aged; D000577:Amides; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D015784:Betaxolol / Q000627:therapeutic use; D000069580:Bimatoprost; D003008:Cloprostenol / Q000031:analogs & derivatives; D004359:Drug Therapy, Combination; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D018259:Herpesvirus 1, Human / Q000254:growth & development*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D016849:Keratitis, Herpetic / Q000139:chemically induced* / Q000188:drug therapy / Q000821:virology; D008055:Lipids / Q000009:adverse effects* / Q000627:therapeutic use; D015242:Ofloxacin / Q000627:therapeutic use; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014775:Virus Activation / Q000187:drug effects*; D014792:Visual Acuity
chemical_list: D000577:Amides; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D000998:Antiviral Agents; D008055:Lipids; D003008:Cloprostenol; C009935:prednisolone acetate; D011239:Prednisolone; D015242:Ofloxacin; D015784:Betaxolol; D000069580:Bimatoprost; D000212:Acyclovir