Preparation and characterization of coenzyme Q10-Eudragit solid dispersion.
A solid dispersion of Coenzyme Q10 and Eudragit L 100-55 was prepared using solvent evaporation method. Solid dispersion, physical mixture, and pure compound were then characterized using differential scanning calorimetry and powder x-ray diffraction. Solubility of CoQ10 in different surfactant media was measured, and a suitable dissolution medium was developed to compare the dissolution patterns of the solid dispersion, physical mixture, and the pure compound. Combining labrasol with different surfactants in dissolution media demonstrated an additive effect on CoQ10 solubility. The solubility of CoQ10 in a 4% Labrasol/2% Cremophor EL solution was 562 microg/ml, which was five times higher than the combined solubility in 5% Labrasol (91 microg/ml) and 5% Cremophor EL (7.8 microg/ml). Moderate change in the crystalline pattern of CoQ10 was observed, which was attributed to solvent displacement rather than the degree of crystallinity change. The dissolution test indicated that the in-vitro release of Coenzyme Q10 from its solid dispersion was much faster than its physical mixture, which in turn was faster than the pure drug. The amount of drug released in 12 hours from solid dispersion, physical mixture, and the pure drug was 100, 26.5 and 12.5% respectively. CoQ10 was photostable throughout the dissolution experiments.
Nazzal
Sami
S
Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo 79106, USA.
Guven
Necip
N
Reddy
Indra K
IK
Khan
Mansoor A
MA
D002152:Calorimetry, Differential Scanning; D002851:Chromatography, High Pressure Liquid; D003067:Coenzymes; D004339:Drug Compounding; D004355:Drug Stability; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012995:Solubility; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000737:chemistry*; D014961:X-Ray Diffraction
D003067:Coenzymes; D011109:Polymethacrylic Acids; D014451:Ubiquinone; C038300:methylmethacrylate-methacrylic acid copolymer; C024989:coenzyme Q10