[Influence of pravastatin on expression of platelet CD(62P) and CD(41) in patients with hypercholesterolemia in vitro and in vivo].
OBJECTIVE
To study in vitro and in vivo effect of hypercholesterolemia (HC) on expression of platelet CD(62P) and CD(41) and their changes after treatment with pravastatin.


METHODS
Twenty patients with HC were given 10 - 20 mg/d pravastatin orally for 4 - 8 weeks. Changes of blood cholesterol and expression of platelet CD(62P) and CD(41) were detected by flow cytometry.


RESULTS
After 4 and 8 weeks' treatment, blood cholesterol level and platelet aggregation function decreased. The expression of CD(62P) average fluorescence intensity decreased from 31.8 +/- 7.8 to 27.2 +/- 6.9 and 26.8 +/- 4.9; CD(62P) (%) from (31.3 +/- 9.3)% to (26.4 +/- 7.4)% and (25.3 +/- 9.1)% (P < 0.05); CD(41) from 483.2 +/- 263.9 to 348.1 +/- 192.4 and 306.8 +/- 128.0 (P < 0.05), respectively. Similar results were obtained in vitro study.


CONCLUSIONS
Improvement of platelet function and expressions of CD(62P) and CD(41) in HC patients after prevastatin treatment may be resulted from enhancing arteriosclerosis regression. It suggested from the in vitro result that pravastatin might play a direct effect on platelet function.
Ma
L
L
Sun Yat-Sen Memorial Hospital, Zhong Shan Medical University, Guangzhou 510120, China.
Xu
L
L
Yin
S
S
Yang
Y
Y
Nie
D
D
Li
Z
Z
Xie
S
S
Feng
J
J
D000328:Adult; D000924:Anticholesteremic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects; D040201:Platelet Membrane Glycoprotein IIb / Q000097:blood*; D017035:Pravastatin / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
D000924:Anticholesteremic Agents; D019007:P-Selectin; D040201:Platelet Membrane Glycoprotein IIb; D002784:Cholesterol; D017035:Pravastatin