[Neonatal bacterial infection by maternal-fetal contamination: for a change in approach? 1. Detection of Streptococcus agalactiae infection: methods and evaluation of results].
Perinatal group B streptococcal infection has been the subject of numerous studies and despite guidelines established during the last decade remains a frequent disease with high mortality. The basic aim of the guidelines is to screen for Streptococcus agalactiae during the antepartum period in order to institute antibiotic therapy during delivery. A critical review of the literature highlights the real impact and adverse effect of these guidelines: difficult application (only two-thirds of all maternity units have a protocol and compliance is only 75%), maternal risks of antibiotic therapy (especially the emergence of resistant Gram negative bacteria), fetal risks (accentuation of neonatal sepsis with resistant strains, retarded neonatal infections, frequent use of antibiotics with a broader spectrum, higher frequency of nosocomial sepsis).
Blond
M H
MH
Service de Médecine Néonatale, Centre de Pédiatrie Gatien-de-Clocheville, 49, boulevard Béranger, 37044 Tours.
Gold
F
F
Pierre
F
F
Quentin
R
R
Aujard
Y
Y
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D001424:Bacterial Infections / Q000635:transmission*; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013290:Streptococcal Infections / Q000175:diagnosis* / Q000517:prevention & control / Q000635:transmission*; D013292:Streptococcus agalactiae
D000900:Anti-Bacterial Agents