Randomized prospective double-blind placebo-controlled trial of effect of intravenous ondansetron on intraocular pressure during ophthalmic surgery.
The effect of i.v. ondansetron, before induction of anaesthesia, on intraocular pressure (IOP) in patients undergoing cataract surgery was investigated. Forty patients (two groups of 20) received either ondansetron 4 mg (treatment group) or 0.9% saline (placebo group) in a double-blind controlled manner. There were no significant differences in IOP between the groups. Ondansetron had no significant effect on IOP during the study period.
Robin
N M
NM
Department of Anaesthesia, Royal Liverpool University Hospital, UK.
Mostafa
S M
SM
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000932:Antiemetics / Q000494:pharmacology*; D002387:Cataract Extraction; D004311:Double-Blind Method; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007432:Intraoperative Period; D008875:Middle Aged; D017294:Ondansetron / Q000494:pharmacology*; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D011229:Preanesthetic Medication; D011446:Prospective Studies
D000932:Antiemetics; D017294:Ondansetron