Diuretic, laxative and toxicity studies of Cocculus hirsutus aerial parts.
The aqueous extract of the Cocculus hirsutus aerial parts (100 and 200 mg/kg, p.o.) showed significant diuretic activity and laxative effect in rats. The acute toxicity, orally evaluated in mice, was found to be higher than 3000 mg/kg.
Ganapaty
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S
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P. 530003, India. ganapatyseru@yahoo.com
Dash
G K
GK
Subburaju
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T
Suresh
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P
D000818:Animals; D002400:Cathartics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003248:Constipation / Q000188:drug therapy; D003967:Diarrhea / Q000188:drug therapy; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D029583:Menispermaceae; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures; D051381:Rats; D017208:Rats, Wistar
D002400:Cathartics; D004232:Diuretics; D010936:Plant Extracts