[The influence of the change in postburn erythrocyte membrane viscoelasticity on the regional myocardial blood flow].
OBJECTIVE
To explore the characteristics of the dynamic change in postburn erythrocyte membrane viscoelasticity and its influence on the regional myocardial blood flow.


METHODS
Wistar rats inflicted with 30% TBSA III degree scalding on the back were employed as the model. The mechanical indices of erythrocytic membrane, such as elastic modulus and the coefficient of viscosity, were determined with micro-pipe sucking methods at preburn and 1, 3, 6, 12, 24 and 48 postburn hours (PBHs). The regional myocardial blood flow was simultaneously monitored with hydrogen clearance methods.


RESULTS
The erythrocyte membrane viscoelasticity increased sharply at 3 PBH, reached the peak level at 6 PBH and decreased gradually thereafter to near normal level at 24 PBH. The regional myocardial blood flow decreased obviously at 1 PBH, it reached the lowest level at 6 PBH and bounced back to near normal level at 48 PBHs. The change in the viscoelasticity was significantly and negatively correlated to that of the regional myocardial blood flow.


CONCLUSIONS
The deformability of postburn erythrocyte membrane decreased, leading to the decrease in the regional myocardial blood flow. This might be one of the important reasons of postburn myocardial injury.
Wu
Q
Q
Institute of Burn Research, Southwestern Hospital, Third Military Medical University, Chongqing 400038, P. R. China.
Wang
X
X
Luo
X
X
D000818:Animals; D002057:Burns, Chemical / Q000097:blood*; D003326:Coronary Circulation; D004195:Disease Models, Animal; D004548:Elasticity; D004910:Erythrocyte Membrane / Q000502:physiology*; D008297:Male; D009206:Myocardium; D051381:Rats; D017208:Rats, Wistar