title: [Focal atrophy with stellate scars in children with chronic gastritis associated to Helicobacter pylori. Is this early atrophic gastritis?].
abstract: BACKGROUND
  Atrophic gastritis has not been described in children in the setting of Helicobacter Pylori infection.
  
  
  METHODS
  Gastric biopsies of six children (7 to 11 years old) with history of HpCG and recent therapeutic eradication of H. Pylori, were reviewed. In the 6 H. Pylori was documented with histology, culture, direct visualization and/or serology before treatment. Cases were compared with five biopsies of age-matched patients showing none of the above-mentioned clinical data. All the biopsies were formalin-fixed, paraffin embedded and stained with hematoxilin-eosin, Masson trichrome and reticulin stain.
  
  
  RESULTS
  The biopsies of the six treated patients showed variable-in-size stellate-shaped spots of glandular loss replaced by dense connective tissue with few inflammatory cells. The fibrous tissue showed a central area of scarring and radially oriented spikes extending to adjacent interglandular tissue, more evident with the Masson trichrome stain. Density of inflammatory cells in the lamina propria was variable. H. Pylori organisms were consistently absent. On the reticulin stain the atrophic areas showed coarser and compacted reticulin. Stellate scars were not present in the five controls.
  
  
  CONCLUSIONS
  Small foci with fibrous scars may be found in children with long standing HpCG, perhaps as an early sequel of it. We hypothesize that if the chronic gastritis-gastric atrophy process is a continuum, these stellate scars may be representing the very beginning of the multifocal atrophic gastritis usually seen in adult patients.
authors.affiliation: Department of Pathology, Hospital de Niños Superiora Sor María Ludovica, La Plata, Argentina.
authors.forename: M C
authors.initials: MC
authors.lastname: Cohen
authors.forename: E
authors.initials: E
authors.lastname: Cueto Rúa
authors.forename: N
authors.initials: N
authors.lastname: Balcarce
authors.forename: G
authors.initials: G
authors.lastname: Quijano
authors.forename: R
authors.initials: R
authors.lastname: Drut
mesh_terms: D001284:Atrophy; D002648:Child; D002908:Chronic Disease; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000188:drug therapy / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000209:etiology / Q000473:pathology; D016481:Helicobacter Infections / Q000188:drug therapy / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D012189:Retrospective Studies