Efficacy of calcitriol to bone resorption and PTH level: clinical study.
Study of the effect of calcitriol (Rocaltrol) to bone markers and PTH level in 146 menopausal women. The result showed a dose of calcitriol 0.75 microgram/day for one month significantly decreased the level of PTH, bone marker for resorption and NMID osteocalcin 61.55, 69.92, 60.02 per cent respectively (p=0.000). The other group which took calcitriol 0.5 microgram/day had little change to such markers. The active form of vitamin D benefits bone health by enhancing osteocalcin formation, in addition vitamin D has moderate antiresorption and suppression of PTH secretion.
Bunyaratavej
N
N
Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Kitimanon
N
N
Tunjariyanond
K
K
D015415:Biomarkers / Q000097:blood; D001862:Bone Resorption / Q000175:diagnosis / Q000517:prevention & control*; D002117:Calcitriol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008593:Menopause / Q000097:blood; D015675:Osteocalcin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood*
D015415:Biomarkers; D010281:Parathyroid Hormone; D015675:Osteocalcin; D002117:Calcitriol