title: Actinobacillus pleuropneumoniae: pathobiology and pathogenesis of infection.
abstract: Actinobacillus pleuropneumoniae causes porcine pleuropneumonia, a highly contagious disease for which there is no effective vaccine. This review considers how adhesins, iron-acquisition factors, capsule and lipopolysaccharide, RTX cytotoxins and other potential future vaccine components contribute to colonisation, to avoidance of host clearance mechanisms and to damage of host tissues.
authors.affiliation: Molecular Infectious Diseases Group, Department of Paediatrics, Faculty of Medicine, Imperial College, St. Mary's Campus, W2 1PG, London, UK. j.bosse@ic.ac.uk
authors.forename: Janine T
authors.initials: JT
authors.lastname: Bossé
authors.forename: Håkan
authors.initials: H
authors.lastname: Janson
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Sheehan
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Beddek
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Rycroft
authors.forename: J Simon
authors.initials: JS
authors.lastname: Kroll
authors.forename: Paul R
authors.initials: PR
authors.lastname: Langford
mesh_terms: D000189:Actinobacillus Infections / Q000382:microbiology* / Q000662:veterinary; D016977:Actinobacillus pleuropneumoniae / Q000472:pathogenicity* / Q000502:physiology; D000818:Animals; D016667:Bacterial Capsules / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism; D008070:Lipopolysaccharides / Q000378:metabolism; D015995:Prevalence; D013552:Swine / Q000382:microbiology*; D013553:Swine Diseases / Q000382:microbiology; D014774:Virulence
chemical_list: D001425:Bacterial Outer Membrane Proteins; D008070:Lipopolysaccharides