title: Effect of shock polarity on the efficacy of transthoracic atrial defibrillation.
abstract: BACKGROUND
  The energy requirement for internal ventricular defibrillation is reduced by reversal of shock polarity. The influence of shock polarity on the efficacy of transthoracic atrial defibrillation is unknown.
  
  
  METHODS
  This prospective, randomized study enrolled 110 consecutive patients who were referred for elective cardioversion of persistent atrial fibrillation (AF). The electrodes were placed in the anteroposterior position. The patients were randomized to receive either standard (anterior pad = cathode) or reversed polarity (anterior pad = anode) shocks with a damped sinusoidal monophasic waveform. A step-up protocol was used to estimate the cardioversion threshold. The initial shock energy was 50 J, with subsequent increments to 100, 200, 300, and 360 J in the event of cardioversion failure.
  
  
  RESULTS
  Sixty-four percent of the patient population were men, with a mean age of 66 +/- 13 years and a mean duration of AF of 242 +/- 556 days. The overall success rates of cardioversion were 84% for standard polarity and 78% for reversed polarity (P not significant). Among the patients who were successfully cardioverted, the mean atrial defibrillation threshold was 198 +/- 103 J for standard polarity and 212 +/- 107 J for reversed polarity (P not significant).
  
  
  CONCLUSIONS
  Reversal of shock polarity does not improve transthoracic cardioversion efficacy with a standard damped sinusoidal monophasic waveform. Alternate strategies should be considered for patients who fail external cardioversion, such as adjunctive pharmacologic treatment, use of a biphasic shock waveform, or internal cardioversion.
authors.affiliation: Division of Cardiology, University of Maryland School of Medicine, Baltimore, Md 21201-1595, USA. Erashba@medicine.umaryland.edu .
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Rashba
authors.forename: Rachida
authors.initials: R
authors.lastname: Bouhouch
authors.forename: Karen A
authors.initials: KA
authors.lastname: MacMurdy
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Shorofsky
authors.forename: Robert W
authors.initials: RW
authors.lastname: Peters
authors.forename: Michael R
authors.initials: MR
authors.lastname: Gold
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000628:therapy*; D004554:Electric Countershock / Q000379:methods*; D004566:Electrodes; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies