[Quality of life and characteristics of the external respiration function in patients with bronchial asthma].
OBJECTIVE
To investigate correlations between quality of life, bronchial obstruction, nonspecific bronchial hyperreactivity (NSBH) and response of these parameters to treatment with inhalation steroids in patients with bronchial asthma (BA).


METHODS
The study included 67 BA patients (47 women and 20 men) aged 18 to 62 years (mean age 43 years). 59 of them had the diagnosis of atopic BA, 8 had bacterial BA. Quality of life was assessed with the questionnaire AQLQ, bronchial obstruction was judged by forced expiratory volume per a second (FEV1). Bronchial hyperreactivity was studied with acetylcholine and histamine tests.


RESULTS
Quality of life strongly correlated with FEV1 and NSBH. Positive changes in the latter due to treatment with inhalation glucocorticoid budesonide (400 mcg/day) entailed improvement of life quality.


CONCLUSIONS
Bronchial obstruction and NSBH have a significant effect on BA patients' life quality which should be considered in monitoring of BA patients' condition.
Emel'ianov
A V
AV
Zinakova
M K
MK
Krasnoshchekova
O I
OI
Sinitsina
T M
TM
Rudinskiĭ
K A
KA
Fedulov
A V
AV
D000109:Acetylcholine; D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000469:parasitology* / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000209:etiology; D019819:Budesonide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012119:Respiration
D000893:Anti-Inflammatory Agents; D019819:Budesonide; D000109:Acetylcholine