title: Endothelial functions in pathophysiology of thrombosis and fibrinolysis: late spontaneous recanalization of an occluded internal carotid artery--a case report.
abstract: The use of oral contraceptives is a potential cause of ischemic stroke in young women. The risk of stroke is higher when contraceptives contain high levels of estrogens. A thrombotic occlusion of the right internal carotid artery, seen on ultrasound, developed in a patient who was taking high-dose estrogen contraception. Recanalization occurred several months later by spontaneous thrombolysis and was confirmed by cerebral angiography. This case suggests that the activation of endothelial spontaneous antithrombotic mechanisms may allow the dissolution of a thrombus, once the cause of the thrombosis has been identified and removed and when the endothelium has maintained its functional integrity.
authors.affiliation: Department of Medicine and Pharmacology, University of Messina, Italy. agatino.manganaro51@unime.it
authors.forename: Agatino
authors.initials: A
authors.lastname: Manganaro
authors.forename: Marinella
authors.initials: M
authors.lastname: Ruggeri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ando
authors.forename: Marcello
authors.initials: M
authors.lastname: Longo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vita
mesh_terms: D000328:Adult; D002341:Carotid Artery Thrombosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D012075:Remission, Spontaneous; D013927:Thrombosis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D003278:Contraceptives, Oral, Hormonal