title: The Golgi apparatus: going round in circles?
abstract: Recent studies have questioned the idea that the Golgi complex is a stable organelle with a unique identity through which secretory cargo is transported by vesicles. Instead, it is proposed that Golgi apparatus proteins continuously recycle via the endoplasmic reticulum by vesicle transport, whereas cargo molecules remain in maturing cisternal structures. Rather than forming a rigid matrix, structural Golgi proteins might be highly dynamic and recycle via the cytoplasm. I will discuss the evidence for these claims and consider whether or not they really disprove older ideas on how the Golgi apparatus is structured and performs its function.
authors.forename: Francis A
authors.initials: FA
authors.lastname: Barr
mesh_terms: D000818:Animals; D022181:COP-Coated Vesicles / Q000378:metabolism / Q000502:physiology; D002352:Carrier Proteins / Q000378:metabolism / Q000502:physiology; D004721:Endoplasmic Reticulum; D006056:Golgi Apparatus / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure*; D006801:Humans; D021381:Protein Transport / Q000502:physiology
chemical_list: D002352:Carrier Proteins