title: HLA-B27-transfected (Salmonella permissive) and HLA-A2-transfected (Salmonella nonpermissive) human monocytic U937 cells differ in their production of cytokines.
abstract: The cytokine secretion of the Salmonella-permissive, HLA-B27-positive U937 cells was examined, as it was previously shown that these cells kill Salmonella less efficiently than controls. Salmonella-permissive U937 cells showed upregulated production of interleukin 10 and to a lesser extent tumor necrosis factor alpha. HLA-B27-associated modulation of cytokine responses may have importance in the pathogenesis of reactive arthritis.
authors.affiliation: National Public Health Institute, Department in Turku, Turku, Finland.
authors.forename: Päivi
authors.initials: P
authors.lastname: Ekman
authors.forename: Marja
authors.initials: M
authors.lastname: Saarinen
authors.forename: Qiushui
authors.initials: Q
authors.lastname: He
authors.forename: Christel
authors.initials: C
authors.lastname: Gripenberg-Lerche
authors.forename: Alvar
authors.initials: A
authors.lastname: Grönberg
authors.forename: Heikki
authors.initials: H
authors.lastname: Arvilommi
authors.forename: Kaisa
authors.initials: K
authors.lastname: Granfors
mesh_terms: D016918:Arthritis, Reactive / Q000209:etiology*; D016207:Cytokines / Q000378:metabolism*; D015789:HLA-A2 Antigen / Q000096:biosynthesis* / Q000235:genetics; D015796:HLA-B27 Antigen / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D009000:Monocytes / Q000276:immunology* / Q000382:microbiology; D012480:Salmonella Infections / Q000276:immunology*; D020298:U937 Cells
chemical_list: D016207:Cytokines; D015789:HLA-A2 Antigen; D015796:HLA-B27 Antigen