title: [Emergencies evolving from local anesthesia].
abstract: Local anesthesia is without doubt the most frequently used drug in dentistry and in medicine. In spite of records of safety set by using these drugs, there is evidence to adverse reactions ranging from 2.5%-11%. Most of the reactions originate from the autonomic system. A recent, well-planned study indicates that adverse reactions are highly correlated to the medical status of the patient: the higher the medical risk, the greater the chance to experience an adverse reaction. This study also found that adverse reactions highly correlated to the concentration of adrenalin. Another recent study found a direct relationship between adverse reactions and the level of anxiety experienced by the patient and to the dental procedure. Most of the reactions in this study occurred either immediately at injection time and within 2 hours following the injection. Since the beginning of last century, vasoconstrictors have been added to local anesthesia solutions in order to reduce toxicity and prologue activity of the LA. However, today it is commonly agreed that this addition to local anesthesia should not be administered to cardiac patients especially those suffering from refractory dysrhythmias, angina pectoris, post myocardial infarction (6 months) and uncontrolled hypertension. Other contraindications to vasoconstrictors are endocrine disorders such as hyperthyroidism, hyperfunction of the medullary adrenal (pheochromocytoma) and uncontrolled diabetes mellitus. Cross reactivity of local anesthetic solutions can occur with MAO inhibitors, non specific beta adrenergic blockers, tricyclic antidepressants, phenothiazides and cocaine abusers. Noradrenaline added to local anesthetics as a vasoconstrictor has been described as a trigger to a great increase in blood pressure and therefore has been forbidden for use in many countries. This paper describes 4 cases of severe complications following the injections of local anesthesia of which three ended in fatality.
authors.affiliation: Dept. of Hospital Oral Medicine, Hebrew University, Hadassah School of Dental Medicine, Jerusalem.
authors.forename: E
authors.initials: E
authors.lastname: Kaufman
authors.forename: A
authors.initials: A
authors.lastname: Garfunkel
authors.forename: M
authors.initials: M
authors.lastname: Findler
authors.forename: S
authors.initials: S
authors.lastname: Elad
authors.forename: S P
authors.initials: SP
authors.lastname: Zusman
authors.forename: S F
authors.initials: SF
authors.lastname: Malamed
authors.forename: D
authors.initials: D
authors.lastname: Galili
mesh_terms: D000766:Anesthesia, Dental / Q000009:adverse effects*; D000772:Anesthesia, Local / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D000075202:Contraindications; D017742:Dental Care for Chronically Ill; D004347:Drug Interactions; D004630:Emergencies; D006801:Humans; D009638:Norepinephrine; D014662:Vasoconstrictor Agents
chemical_list: D014662:Vasoconstrictor Agents; D009638:Norepinephrine