title: [Preformulation study of atenolol-containing solutions.. I. The pH dependence of thermostability].
abstract: The stability of atenolol solutions was evaluated under accelerated isothermal degradation conditions at 90 degrees C. A specific and sensitive HPLC method was adapted to study the pH dependence of the stability. The maximum stability of atenolol was achieved at pH 4 with a k value of 1.1 x 10(-3) h-1. The degradation of atenolol followed first-order kinetics at above mentioned conditions.
authors.affiliation: Semmelweis Egyetem Budapest, Gyógyszerészeti Intézet 1092 Budapest, Hógyes E. u. 7.
authors.forename: S
authors.initials: S
authors.lastname: Marton
authors.forename: A
authors.initials: A
authors.lastname: Hatem
authors.forename: G
authors.initials: G
authors.lastname: Csóka
authors.forename: I
authors.initials: I
authors.lastname: Rácz
mesh_terms: D001262:Atenolol / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D012996:Solutions
chemical_list: D012996:Solutions; D001262:Atenolol