[Keratinocyte immunophenotypes in patients with psoriatic arthritis and their changes after treatment with deresinated naphthalan].
The study of phenotyping features, membrane markers of epidermic keratinocytes, their production of adhesive molecules has established structural basis of favourable effect of deresinated naphthalan on the skin and articular syndromes in patients with psoriatic adtheritis. The immunohistochemical examination of the skin biopsies using monoclonal antibodies in the test of indirect immunofluorescence has found that deresinated naphthalan in patients suppresses immunoinflammatory reactions in the skin. Monitoring of expression of molecules HLA--on keratinocytes may be helpful for prediction of the skin and joint manifestation.
Badalov
N G
NG
Tupitsyn
N N
NN
Grigor'eva
V D
VD
D000287:Administration, Topical; D015535:Arthritis, Psoriatic / Q000276:immunology / Q000628:therapy*; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology; D006358:Hot Temperature; D006801:Humans; D016130:Immunophenotyping; D015603:Keratinocytes / Q000276:immunology*; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage*
D006684:HLA-DR Antigens; D009281:Naphthalenes; C007229:decalin