title: [Vasopressin and inflammation].
abstract: At least three vasopressinergic brain systems are involved in inflammatory reaction. The first one is VP neurons of the bed nucleus of stria terminalis, projecting to antipyretic center in the preoptic forebrain region. The second system is neurons of the parvocellular subnucleus of the hypothalmic paraventricular nucleus. VP from these neurons reaches portal blood through the external zone of the median eminence. VP potentiates the effect of corticotropin releasing hormone on ACTH cells in the anterior pituitary. Synergetic modulation of pituitary-adrenal axis by these neurohormones maintains synthesis and release of glucocorticosteroids. The latter plays crucial role as endogenous immunosuppresants. The third VP system is magnocellular hypothalamic neurons that release vasopressin into general circulation. Systemic VP is capable of compensating the water lost caused by symptoms of inflammation. The review is devoted to analysis of current information concerning physiology and interactions between these systems during acute and chronic inflammation. The special reference has been made on the magnocellular neurons and the role of circulating vasopressin in the renal function regulation.
authors.affiliation: Laboratory of Experimental Morphology, Institute of Experimental Endocrinology, Endocrinology Scientific Centre, RAMS, Department of Histology and Embryology, Pediatric Faculty of Russian State Medical University, Moscow.
authors.forename: I G
authors.initials: IG
authors.lastname: Akmaev
authors.forename: O V
authors.initials: OV
authors.lastname: Volkova
authors.forename: V V
authors.initials: VV
authors.lastname: Grinevich
authors.forename: A V
authors.initials: AV
authors.lastname: Misharin
authors.forename: E A
authors.initials: EA
authors.lastname: Poskrebysheva
authors.forename: A B
authors.initials: AB
authors.lastname: Resnenko
authors.forename: N A
authors.initials: NA
authors.lastname: Savelov
mesh_terms: D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D001921:Brain / Q000502:physiology; D007249:Inflammation / Q000503:physiopathology*; D014667:Vasopressins / Q000502:physiology*
chemical_list: D014667:Vasopressins