title: Epidural lipomatosis secondary to indinavir in an HIV-positive patient.
abstract: A human immunodeficiency virus-positive patient receiving indinavir therapy developed a slowly progressive paraparesis. Magnetic resonance imaging findings were consistent with epidural lipomatosis. On discontinuing indinavir, symptoms gradually remitted. Although indinavir, a protease inhibitor, is known to cause abnormal fat accumulation, to the best of our knowledge this is the first report of epidural lipomatosis.
authors.affiliation: Department of Neurology and Infectious Diseases, Hospital de Clínicas "José de San Martín," U.B.A., Buenos Aires, Argentina.
authors.forename: María Graciela
authors.initials: MG
authors.lastname: Cersósimo
authors.forename: Beatriz
authors.initials: B
authors.lastname: Lasala
authors.forename: Silvia
authors.initials: S
authors.lastname: Folgar
authors.forename: Federico
authors.initials: F
authors.lastname: Micheli
mesh_terms: D000328:Adult; D004824:Epidural Space; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D015497:HIV-1; D006801:Humans; D006987:Hypesthesia / Q000139:chemically induced; D019469:Indinavir / Q000009:adverse effects* / Q000627:therapeutic use; D007866:Leg; D008068:Lipomatosis / Q000139:chemically induced*; D008279:Magnetic Resonance Imaging; D008297:Male; D020335:Paraparesis / Q000139:chemically induced; D010292:Paresthesia / Q000139:chemically induced; D013118:Spinal Cord Diseases / Q000139:chemically induced*; D013904:Thoracic Vertebrae
chemical_list: D017320:HIV Protease Inhibitors; D019469:Indinavir