Fc receptors and immunity to parasites.
Fc receptors (FcRs) are crucial in the immune system; they mediate a plethora of biological functions as diverse as antigen presentation, phagocytosis, cytotoxicity, induction of inflammatory cascades and modulation of immune responses. Parasites, in order to survive in the immunocompetent host, have devised ingenious methods to subvert this important aspect of the immune response. This article discusses the current thinking on FcRs, their role in immunity to parasites, and immune evasion strategies employed by parasites in their attempt to neutralize the important immune defense mechanisms mediated by these molecules.
Pleass
R J
RJ
Dept. of Molecular and Cellular Pathology, University of Dundee Medical School, Ninewells Hospital, DD1 9SY, Dundee, UK. r.j.pleass@dundee.ac.uk
Woof
J M
JM
D000818:Animals; D030801:Animals, Genetically Modified; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology; D004198:Disease Susceptibility; D006790:Host-Parasite Interactions; D006801:Humans; D008288:Malaria / Q000276:immunology; D051379:Mice; D010272:Parasitic Diseases / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology; D011110:Polymorphism, Genetic; D011961:Receptors, Fc / Q000276:immunology / Q000502:physiology*; D012106:Research
D011961:Receptors, Fc