title: Does donor cause of death affect the outcome of lung transplantation?
abstract: BACKGROUND
  Accumulating evidence suggests that the donor's cause of death may influence posttransplantation allograft function. We conducted a retrospective analysis of our adult lung transplant experience to investigate the influence of donor traumatic brain injury versus nontraumatic brain injury on posttransplantation outcome.
  
  
  METHODS
  We retrospectively reviewed donor records and recipient medical charts for 500 consecutive lung transplants performed between July 1988 and December 1999. Recipient follow-up was complete, with a minimum follow-up of 1 year of survival.
  
  
  RESULTS
  There were 295 and 205 donors in the traumatic and nontraumatic brain injury groups, respectively. Young male donors predominated in the traumatic brain injury group. Recipients receiving donor lungs from the traumatic and nontraumatic brain injury groups did not differ by age, sex, diagnosis, type of transplant (single-lung versus double-lung) or requirement for pretransplantation mechanical ventilatory assistance. Recipients did not differ in immediate or 24-hour PaO (2)/inspired oxygen ratio, ventilation time, hospital stay, hospital mortality, or overall survival. Recipients of organs from donors who died of traumatic brain injury showed a higher severity and frequency of rejection episodes during the first year after transplantation. Freedoms from bronchiolitis obliterans syndrome at 5 years were 34.5% and 50.8% for recipients of organs from donors who died of traumatic and nontraumatic brain injury, respectively (P =.002).
  
  
  CONCLUSIONS
  The cause of donor brain death does not appear to influence early results of lung transplantation. Traumatic brain injury, or some phenomenon associated with it, may predispose a transplanted lung and its recipient toward more severe early rejection episodes and subsequent development of bronchiolitis obliterans syndrome.
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Ciccone
authors.forename: Ken C
authors.initials: KC
authors.lastname: Stewart
authors.forename: Bryan F
authors.initials: BF
authors.lastname: Meyers
authors.forename: Tracey J
authors.initials: TJ
authors.lastname: Guthrie
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Battafarano
authors.forename: Elbert P
authors.initials: EP
authors.lastname: Trulock
authors.forename: Joel D
authors.initials: JD
authors.lastname: Cooper
authors.forename: G Alexander
authors.initials: GA
authors.lastname: Patterson
mesh_terms: D000328:Adult; D001930:Brain Injuries; D001989:Bronchiolitis Obliterans / Q000209:etiology; D002423:Cause of Death; D005260:Female; D006084:Graft Rejection; D006801:Humans; D008171:Lung Diseases / Q000601:surgery; D016040:Lung Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D012189:Retrospective Studies; D014019:Tissue Donors; D016896:Treatment Outcome