Increased serum thymidine kinase activity in acute sarcoidosis.
This is the first case report of acute sarcoidosis with increased serum thymidine kinase (TK) activity. A 43-year-old male presented fever, swelling of parotid glands, lymphadenopathy, and peripheral neuropathy. Sarcoidosis was pathologically diagnosed by lung and parotid gland biopsy. His serum TK, which was increased to 11.2 U/l at diagnosis (normal <5 U/l), normalized after glucocorticoid therapy. Serum TK has been considered as a good marker of the proliferative activity of various types of neoplasms. Its rise in sarcoidosis has, however, not been described. Because acute sarcoidosis sometimes resembles malignant lymphoma, the possible rise of serum TK in sarcoidosis may be worthy of note.
Tajima
Syunji
S
Second Department of Internal Medicine, Gunma University, Maebashi.
Sando
Yoshichika
Y
Maeno
Toshitaka
T
Sagawa
Naoki
N
Nara
Mami
M
Maeno
Yuri
Y
Nakagawa
Junichi
J
Ito
Toshio
T
Hoshino
Yoichi
Y
Suga
Tatsuo
T
Arai
Masashi
M
Kurabayashi
Masahiko
M
D000208:Acute Disease; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015415:Biomarkers; D001706:Biopsy; D003937:Diagnosis, Differential; D015769:Granuloma, Respiratory Tract / Q000209:etiology / Q000473:pathology; D006801:Humans; D008206:Lymphatic Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D008223:Lymphoma / Q000175:diagnosis / Q000201:enzymology; D008297:Male; D010306:Parotid Gland / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography; D012507:Sarcoidosis / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D013937:Thymidine Kinase / Q000097:blood*; D014777:Virus Diseases / Q000175:diagnosis / Q000201:enzymology
D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D011239:Prednisolone; D013937:Thymidine Kinase