Improving structure-linked access to publicly available chemical toxicity information.
Publicly available toxicity databases serve as the central resource in efforts to develop algorithms for assessing potential chemical toxicity. File standardization and linkage of chemical structures with chemical toxicity information are essential first steps in providing broad access to existing toxicity information, for deriving useful structure-activity relationship (SAR) models, performing analog searches, and estimating the potential toxicity of new chemicals. This review will focus on current efforts to improve structure-linked access to publicly available sources of toxicity information, outlining current web-based resources as well as two new database initiatives for standardizing and consolidating public chemical toxicity information.
Richard
Ann M
AM
US Environmental Protection Agency, Mail Drop 68, National Health and Environmental Effects Research Laboratories, Research Triangle Park, NC 27711, USA. richard.ann@epamail.epa.gov
Williams
ClarLynda R
CR
Cariello
Neal F
NF
D003195:Computer Communication Networks; D016208:Databases, Factual / Q000592:standards / Q000639:trends*; D004353:Drug Evaluation, Preclinical / Q000592:standards*; D020407:Internet; D011237:Predictive Value of Tests; D013329:Structure-Activity Relationship; D014116:Toxicology / Q000592:standards / Q000639:trends*