mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons.
Here we describe the expression pattern of a previously unknown mouse gene mPet-1. The isolated cDNA codes for an ETS-domain transcription factor of 237 amino acids in length, which is localized to the nucleus. mPet-1 is a member of the winged helix transcription factor gene family like its rat homologue Pet-1 and the human homologue FEV. The start ATG of mPet-1 and the size of the predicted protein are identical to the human FEV. The mPet-1 protein is clearly smaller since it lacks the first 103 N-terminal amino acids of rat Pet-1. mPet- 1 is expressed in central serotonergic (5-hydroxytryptaminergic) neurons located in the mes-/metencephalic raphe nuclei from E11 on until adulthood. In these regions mPet-1 expression co-localizes precisely with the serotonin transporter (Sert),which it initially precedes. Interestingly, mPet-1 was not found in neurons transiently expressing Sert.
Pfaar
Harald
H
GSF-Research Center for Environment and Health, Institute for Mammalian Genetics, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
von Holst
Alexander
A
Vogt Weisenhorn
Daniela M
DM
Brodski
Claude
C
Guimera
Jordi
J
Wurst
Wolfgang
W
D000595:Amino Acid Sequence; D000818:Animals; D051379:Mice; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D016415:Sequence Alignment; D012701:Serotonin / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
C484684:Fev protein, mouse; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D012701:Serotonin