Pulmonary colonization by Chrysosporium zonatum associated with allergic inflammation in an immunocompetent subject.
We report a case of noninvasive pulmonary disease due to Chrysosporium zonatum in an immunocompetent male. The fungus colonized an existing tuberculous cavity and was isolated from transbronchial lavage fluid and from a percutaneous aspiration specimen. The disease was accompanied by the unusual feature of an allergic reaction. The fungus ball was successfully treated by intracavitary administration of amphotericin B. C. zonatum is the anamorph of the heterothallic ascomycete Uncinocarpus orissi, and the identity of the case isolate was verified by formation of ascospores in mating tests with reference isolates.
Hayashi
Shinichiro
S
Division of Pulmonary Diseases, Department of Internal Medicine, Microbiology Branch, Saga Medical School, Saga, Japan. hayashs@post.saga-med.ac.jp
Naitoh
Keiko
K
Matsubara
Shinichi
S
Nakahara
Yoshiaki
Y
Nagasawa
Zenzo
Z
Tanabe
Ichiro
I
Kusaba
Kohzi
K
Tadano
Jutaro
J
Nishimura
Kazuko
K
Sigler
Lynne
L
D000368:Aged; D000666:Amphotericin B / Q000494:pharmacology; D002912:Chrysosporium / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D006967:Hypersensitivity / Q000382:microbiology*; D007249:Inflammation / Q000382:microbiology*; D008168:Lung / Q000382:microbiology*; D008172:Lung Diseases, Fungal / Q000382:microbiology*; D008297:Male; D008826:Microbial Sensitivity Tests
D000666:Amphotericin B