Alu polymorphism within the MICB gene and association with HLA-B alleles.
We describe the finding of an Alu repeat dimorphism within the first intron of the MICB gene. The frequencies of the two AluyMICB alleles, AluyMICB*0(absence of insertion) and AluyMICB*1(presence of insertion), and their associations with the highly polymorphic HLA-B locus were determined for 51 human cell lines and for 109 and 200 Caucasians and northeastern Thais, respectively. Analysis of the AluyMICB and HLA-B allelic relationships revealed that AluyMICB*1 occurred at relatively low gene frequency (0.118-0.157) [corrected] but was strongly associated with HLA-B17 (HLA-B57,HLA-B58) and HLA-B13. The AluyMICB locus provides a useful dimorphic marker for investigations on the level of linkage disequilibrium between MICB, MICA, and HLA-B loci.
Kulski
Jerzy K
JK
Centre for Bioinformatics and Biological Computing, School of Information Technology, Murdoch University, Murdoch, 6150 Western Australia, Australia. jkulski@murdoch.edu.au
Dunn
David S
DS
Hui
Jennie
J
Martinez
Patricia
P
Romphruk
Amornrat V
AV
Leelayuwat
Chanvit
C
Tay
Guan K
GK
Oka
Akira
A
Inoko
Hidetoshi
H
D000483:Alleles; D020087:Alu Elements / Q000235:genetics*; D001483:Base Sequence; D002460:Cell Line; D023061:Gene Order; D015235:HLA-B Antigens / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D015235:HLA-B Antigens; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; C098080:MICB antigen