title: The effect of two moisturisers on skin barrier damage in allergic contact dermatitis.
abstract: Nickel (Ni)-induced allergic contact dermatitis (ACD) was performed in human volunteers to study the role of moisturisers in preventing ACD-related skin barrier damage. 15 Ni-sensitive females (mean age: 29.5 years; range: 23-38) were included. On days 1, 21, 24 and 26, TEWL, stratum corneum (SC)-capacitance and clinical score were evaluated on four test sites on the right and left forearms. Both a highly and a poorly hydrating moisturising formulation were applied on two sites from days 1 to 21, after which Ni-ACD was induced on the 2 pre-treated sites and one non-treated area. On day 24, TEWL values were significantly increased on the site pre-treated with poorly hydrating product compared to the rich formulation pre-treated site. SC-hydration was significantly improved on the latter site on days 21, 23 and 26. Long-term use of inadequate moisturiser increases skin barrier damage due to Ni-ACD.
authors.affiliation: Department of Toxicology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Hachem
authors.forename: Kristien
authors.initials: K
authors.lastname: De Paepe
authors.forename: Els
authors.initials: E
authors.lastname: Vanpee
authors.forename: Leonard
authors.initials: L
authors.lastname: Kaufman
authors.forename: Vera
authors.initials: V
authors.lastname: Rogiers
authors.forename: Diane
authors.initials: D
authors.lastname: Roseeuw
mesh_terms: D000328:Adult; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000517:prevention & control*; D004643:Emollients / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009532:Nickel / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D014870:Water Loss, Insensible / Q000187:drug effects
chemical_list: D004643:Emollients; D009532:Nickel