[Influence of free radical inducer on the level of oxidative stress in brain of rats with fluorosis].
OBJECTIVE
To study changes in content of lipid peroxide and composition of fatty acids in the brain of rats affiliated with chronic fluorosis after treatment with free radical inducer (ferric ion).


METHODS
Thirty-six Wistar rats were divided into three groups, fed with similar fodder and varied concentrations of fluoride in drinking water, and were killed five months after treatment. Lipid peroxidation was induced by ferric ions. Malondialdehyde content in brain was analysed by high-performance liquid chromatography; oxygen consumption was determined with an oxygen electrode and fatty acid composition was measured by gas chromatography in brain tissues of the rats.


RESULTS
In the brain tissues, content of malondialdehyde and oxygen consumption increased, composition of polyunsaturated fatty acids decreased and that of saturated fatty acids decreased after treatment with free radical inducer in the treated group, as compared with those in control group.


CONCLUSIONS
Over uptake of fluoride for a long term could cause potential increase in the level of oxidative stress in the brain tissue.
Shao
Q
Q
Department of Neurology, Guiyang Medical College, Guizhou 550004, China.
Wang
Y
Y
Guan
Z
Z
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D005458:Fluoride Poisoning / Q000378:metabolism*; D005609:Free Radicals; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D010101:Oxygen Consumption; D051381:Rats; D017208:Rats, Wistar; D012969:Sodium Fluoride / Q000009:adverse effects
D005227:Fatty Acids; D005609:Free Radicals; D008315:Malondialdehyde; D012969:Sodium Fluoride