Diagnosis of Helicobacter pylori infection in children: comparison of a salivary immunoglobulin G antibody test with the [(13)C]urea breath test.
The prevalence of Helicobacter pylori infection in a population-based sample of 477 children (mean age plus minus standard deviation, 5.8 plus minus 0.5 years) determined by the [(13)C]urea breath test ([(13)C]UBT) was 10.7% (95% confidence interval [CI], 8.1 to 13.8%), and that determined by salivary enzyme-linked immunosorbent assay (ELISA) was 11.9% (95% CI, 9.2 to 15.2%). Compared to the [(13)C]UBT, the sensitivity and specificity of the salivary ELISA were 80.9% (95% CI, 66.3 to 90.4%) and 95.3% (95% CI, 92.7 to 97.1%), respectively.
Bode
G
G
Department of Epidemiology, University of Ulm, Ulm, Germany. guenter@bode@medizin.uni-ulm.de
Marchildon
P
P
Peacock
J
J
Brenner
H
H
Rothenbacher
D
D
D000907:Antibodies, Bacterial / Q000032:analysis*; D001944:Breath Tests; D002247:Carbon Isotopes; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D012463:Saliva / Q000276:immunology*; D012680:Sensitivity and Specificity; D014508:Urea / Q000032:analysis*
D000907:Antibodies, Bacterial; D002247:Carbon Isotopes; D007074:Immunoglobulin G; D014508:Urea