title: On the detection of early cochlear damage by otoacoustic emission analysis.
abstract: Theoretical considerations and experimental evidence suggest that otoacoustic emission parameters may be used to reveal early cochlear damage, even before it can be diagnosed by standard audiometric techniques. In this work, the statistical distributions of a set of otoacoustic emission parameters chosen as candidates for the early detection of cochlear damage (global and band reproducibility, response level, signal-to-noise ratio, spectral latency, and long-lasting otoacoustic emission presence) were analyzed in a population of 138 ears. These ears have been divided, according to a standard audiometric test, in three classes: (1) ears of nonexposed bilaterally normal subjects, (2) normal ears of subjects with unilateral noise-induced high-frequency hearing loss, and (3) their hearing impaired ears. For all analyzed parameters, a statistically significant difference was found between classes 1 and 2. This difference largely exceeds the difference observed between classes 2 and 3. This fact suggests that the noise exposure, which was responsible for the unilateral hearing loss, also caused subclinical damage in the contralateral, audiometrically normal, ear. This is a clear indication that otoacoustic emission techniques may be able to early detect subclinical damages.
authors.affiliation: Italian Air Force--CSV Aerospace Medicine Department, Pratica di Mare AFB, Pomezia, Roma.
authors.forename: M
authors.initials: M
authors.lastname: Lucertini
authors.forename: A
authors.initials: A
authors.lastname: Moleti
authors.forename: R
authors.initials: R
authors.lastname: Sisto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000502:physiology; D003051:Cochlea / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D034381:Hearing Loss / Q000175:diagnosis* / Q000503:physiopathology*; D006316:Hearing Loss, High-Frequency / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D012720:Severity of Illness Index; D013997:Time Factors