title: Ellagitannins from Lagerstroemia speciosa as activators of glucose transport in fat cells.
abstract: Glucose transport enhancers were searched for in Lagerstroemia speciosa, a Philippine local herbal medicine used for diabetes mellitus. Bioassay-guided fractionation of the aqueous acetone extract of the leaves afforded three active ellagitannins, lagerstroemin, flosin B and reginin A, identified by NMR and optical rotation. These compounds increased glucose uptake of rat adipocytes, and could be responsible for lowering the blood glucose level.
authors.forename: Takeo
authors.initials: T
authors.lastname: Hayashi
authors.forename: Haruko
authors.initials: H
authors.lastname: Maruyama
authors.forename: Royji
authors.initials: R
authors.lastname: Kasai
authors.forename: Katsuji
authors.initials: K
authors.lastname: Hattori
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Takasuga
authors.forename: Osamu
authors.initials: O
authors.lastname: Hazeki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamasaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D003847:Deoxyglucose / Q000378:metabolism; D047348:Hydrolyzable Tannins; D029561:Lythraceae; D009004:Monosaccharide Transport Proteins / Q000187:drug effects*; D010679:Philippines; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D013634:Tannins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D047348:Hydrolyzable Tannins; D009004:Monosaccharide Transport Proteins; D010936:Plant Extracts; D013634:Tannins; C013515:ellagitannin; C455119:flosin B; C455118:lagerstroemin; C455120:reginin A; D003847:Deoxyglucose