[Effect of sodium fluoride on bone turnover and bone loss of vertebrae and tibia in ovariectomized rats].
OBJECTIVE
To investigate the effect of sodium fluoride on bone turnover and bone loss of vertebra and tibia of ovariectomized rats.


METHODS
34 female Wistar rats, 16 weeks old, were divided into 3 groups: sham-ovariectomy (CON), bilateral ovariectomy (OVX) and both OVX and NaF-treatment groups (OVX + NaF, 1.0 mg/kg BW). All of the rats were sacrificed 12 weeks after the treatment. Serum was collected for the analysis of estradiol, calcium, phosphorum and alkaline phosphotase. Temur was used for the analysis of calcium content. Tibiae and the first lumbar vertebral bodies were decalcified for histomorphometry.


RESULTS
After treatment with NaF, bone resorption was not inhibited, but bone formation was significantly increased. The trabecular bone volume of vertebrae (18.73% +/- 3.04%) and tibiae (14.30% +/- 5.87%) was significantly increased in comparing with of OVX rats (15.07% +/- 2.45% and 8.81% +/- 2.60%, P < 0.05), but it was markedly lower than that of CON rats (22.44% +/- 1.82% and 24.87% +/- 4.02%, P < 0.05 and P < 0.01).


CONCLUSIONS
NaF could not decrease bone turnover and it, has only a partial protective effect against bone loss of either vertebra or tibia.
Zhang
M
M
Department of Pathology, Tianjin Medical University, Tianjin 300070, China.
Huang
F
F
Tan
Y
Y
Zhao
H
H
Jin
M
M
Ma
S
S
D000818:Animals; D001862:Bone Resorption / Q000473:pathology*; D005260:Female; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000473:pathology*; D010012:Osteogenesis / Q000187:drug effects*; D010024:Osteoporosis / Q000473:pathology; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D012969:Sodium Fluoride / Q000494:pharmacology*; D013977:Tibia / Q000187:drug effects / Q000473:pathology*
D012969:Sodium Fluoride