title: Analysis of motor pathway involvement in konzo using transcranial electrical and magnetic stimulation.
abstract: To elucidate the involvement of motor pathways in konzo, 21 konzo subjects (mean age 22 years) underwent transcranial electrical stimulation (TES) in 1998. Fourteen konzo subjects (mean age 21 years) underwent transcranial magnetic stimulation (TMS) in 2000. Three subjects underwent both TES and TMS. Motor evoked potentials (MEPs) were recorded in the abductor pollicis brevis (APB) muscle with TES, and in the abductor digiti minimi (ADM) and tibialis anterior (TA) muscles with TMS. APB-MEPs were normal in 2 of 21 subjects and absent in 9; central conduction time (CCT) was prolonged in 10. Resting ADM-MEPs were absent in 9 of 14 subjects with clinically preserved upper limbs. Among these nine, seven subjects responded after facilitation. Most subjects (13 of 14) failed to show TA-MEPs. Of the subjects who underwent both types of stimulation, one had normal TES-MEP but abnormal ADM-MEP with TMS. These findings suggest involvement of both corticomotoneurons and motor descending pathways in konzo.
authors.affiliation: Department of Neurology, Kinshasa University Hospital, Kinshasa, Democratic Republic of Congo.
authors.forename: Desire
authors.initials: D
authors.lastname: Tshala-Katumbay
authors.forename: Karin Edebol
authors.initials: KE
authors.lastname: Eeg-Olofsson
authors.forename: Theodore
authors.initials: T
authors.lastname: Kazadi-Kayembe
authors.forename: Thorkild
authors.initials: T
authors.lastname: Tylleskär
authors.forename: Peo
authors.initials: P
authors.lastname: Fällmar
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology; D002648:Child; D004558:Electric Stimulation; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D006801:Humans; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology*; D009069:Movement Disorders / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology; D009434:Neural Pathways / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology