title: Hemoglobin F synthesis is not restricted to fetal erythropoietic organs during extramedullary hematopoiesis.
abstract: We investigated whether the anatomic distribution of hematopoietic cells determines the type of hemoglobin produced in patients with extramedullary hematopoiesis (EMH). Fetal hemoglobin (HbF) production is not restricted to fetal erythropoietic organs during EMH. A shift of erythropoiesis to fetal hematopoietic organs in EMH does not necessarily induce HbF synthesis in adulthood.
authors.forename: Jong Weon
authors.initials: JW
authors.lastname: Choi
authors.forename: Yonggoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Masahiko
authors.initials: M
authors.lastname: Fujino
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ito
mesh_terms: D000328:Adult; D004900:Erythroblasts / Q000378:metabolism; D004920:Erythropoiesis; D005319:Fetal Hemoglobin / Q000032:analysis / Q000096:biosynthesis*; D019337:Hematologic Neoplasms / Q000378:metabolism / Q000473:pathology; D006411:Hematopoiesis, Extramedullary; D006441:Hemoglobin A / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry
chemical_list: D006441:Hemoglobin A; D005319:Fetal Hemoglobin