[Interrelations of hyperplasia of gastric mucosa and helicobacter infection (based on data from a polyclinic center].
OBJECTIVE
To examine a relationship of hyperplastic processes in the gastric mucosa (GM) to Helicobacter infections.


METHODS
A hundred patients aged 44 to 86 years who had gastric polyps [Group 1, foveolar hyperplasia (n = 21); Group 2, hyperplasiogenic polyps (n = 65), Group 3, adenomas (n = 14)] underwent esophagogastroduodenoscopy with biopsy of the mucosa from the athrum, body, and fundus of the stomach to reveal Helicobacter pylori (Hp) and GM morphological changes.


RESULTS
Hp-associated chronic gastritis was detected in 56% of the patients (66.7, 52.3, and 57.1% in Groups 1, 2, and 3, respectively). The rate of Hp seeding correlated with the magnitude of inflammatory and dystrophic changes. As the regulation of epithelial growth and differentiation impairs, the magnitude of GM structural alterations increase.


CONCLUSIONS
The findings indicate that there may be a relationship between the frequency, degree of Hp infection and the pattern of GM morphological changes, which makes it expedient to use eradication therapy in this group of patients.
Minushkin
O N
ON
Arutiunov
A G
AG
Burkov
S G
SG
Burdina
E G
EG
Kutepova
S Iu
SIu
D018256:Adenomatous Polyps / Q000209:etiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016145:Endoscopy, Digestive System; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000150:complications*; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000209:etiology*; D013274:Stomach Neoplasms / Q000209:etiology*