title: Diuretic, laxative and toxicity studies of Cocculus hirsutus aerial parts.
abstract: The aqueous extract of the Cocculus hirsutus aerial parts (100 and 200 mg/kg, p.o.) showed significant diuretic activity and laxative effect in rats. The acute toxicity, orally evaluated in mice, was found to be higher than 3000 mg/kg.
authors.affiliation: Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P. 530003, India. ganapatyseru@yahoo.com
authors.forename: S
authors.initials: S
authors.lastname: Ganapaty
authors.forename: G K
authors.initials: GK
authors.lastname: Dash
authors.forename: T
authors.initials: T
authors.lastname: Subburaju
authors.forename: P
authors.initials: P
authors.lastname: Suresh
mesh_terms: D000818:Animals; D002400:Cathartics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003248:Constipation / Q000188:drug therapy; D003967:Diarrhea / Q000188:drug therapy; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D029583:Menispermaceae; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002400:Cathartics; D004232:Diuretics; D010936:Plant Extracts