Identification of indolyl-3-acryloylglycine in the urine of people with autism.
HPLC analysis of the urine of autistic subjects indicated the presence of an unidentified component in greatly increased concentrations. We have reported the isolation of this component by HPLC and its identification. Mass spectrometry, NMR and UV spectroscopy identified the peak as corresponding to indolyl-3-acryloylglycine (IAG, 3), and this has been confirmed by an independent synthesis.
Anderson
Rosaleen J
RJ
Institute of Pharmacy, Chemistry and Biomedical Sciences, University of Sunderland, UK. roz.anderson@sunderland.ac.uk
Bendell
David J
DJ
Garnett
Ian
I
Groundwater
Paul W
PW
Lough
W John
WJ
Mills
Malcolm J
MJ
Savery
Dawn
D
Shattock
Paul E G
PE
D001321:Autistic Disorder / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D005998:Glycine / Q000031:analogs & derivatives* / Q000652:urine*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
C001807:indolylacryloylglycine; D005998:Glycine