title: Synchrotron radiation imaging of internal structures in live animals.
abstract: Ionizing radiation has long been used in medicine since the discovery of X-rays. Diagnostic imaging using synchrotron radiation has been under investigation since Rubenstein et al. reported dual-energy iodine-K-edge subtraction coronary angiography. Recently, computed tomography (CT) and magnetic resonance imaging (MRI) have provided better quality results than conventional radiology, providing important information on human internal structures. However, such techniques are unable to detect fine micron sized structures for the early diagnosis of tumors, vascular diseases and other medical objectives. Third generation synchrotron X-rays are well known for their superiority in coherence and energy tunability with respect to conventional X-rays. Consequently, new contrast mechanisms with a superior spatial resolution are becoming available. Here we present the extremely fine details of live animal internal structures using unmonochromatized synchrotron X-rays (white beam) and a simple detector system. Natural movements of the internal organs are also shown. The results indicate that this imaging technique can be applied to investigating microstructures and evaluating the function of the internal organs. Furthermore, this imaging system may be applied to humans as the next tool beyond CT and MRI.
authors.affiliation: Medical Research Center, Academia Sinica, Taipei, Taiwan. lkh@yumc.yonsei.ac.kr
authors.forename: Kyu Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Yeu Kuang
authors.initials: YK
authors.lastname: Hwu
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Je
authors.forename: Wen Li
authors.initials: WL
authors.lastname: Tsai
authors.forename: Eun Wook
authors.initials: EW
authors.lastname: Choi
authors.forename: Yong Chul
authors.initials: YC
authors.lastname: Kim
authors.forename: Hee Joung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Je Kyung
authors.initials: JK
authors.lastname: Seong
authors.forename: Seung Won
authors.initials: SW
authors.lastname: Yi
authors.forename: Hyung Sik
authors.initials: HS
authors.lastname: Ryo
authors.forename: Giorgio
authors.initials: G
authors.lastname: Margaritondo
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D017356:Synchrotrons