title: [Neonatal bacterial infection by maternal-fetal contamination: for a change in approach? 1. Detection of Streptococcus agalactiae infection: methods and evaluation of results].
abstract: Perinatal group B streptococcal infection has been the subject of numerous studies and despite guidelines established during the last decade remains a frequent disease with high mortality. The basic aim of the guidelines is to screen for Streptococcus agalactiae during the antepartum period in order to institute antibiotic therapy during delivery. A critical review of the literature highlights the real impact and adverse effect of these guidelines: difficult application (only two-thirds of all maternity units have a protocol and compliance is only 75%), maternal risks of antibiotic therapy (especially the emergence of resistant Gram negative bacteria), fetal risks (accentuation of neonatal sepsis with resistant strains, retarded neonatal infections, frequent use of antibiotics with a broader spectrum, higher frequency of nosocomial sepsis).
authors.affiliation: Service de Médecine Néonatale, Centre de Pédiatrie Gatien-de-Clocheville, 49, boulevard Béranger, 37044 Tours.
authors.forename: M H
authors.initials: MH
authors.lastname: Blond
authors.forename: F
authors.initials: F
authors.lastname: Gold
authors.forename: F
authors.initials: F
authors.lastname: Pierre
authors.forename: R
authors.initials: R
authors.lastname: Quentin
authors.forename: Y
authors.initials: Y
authors.lastname: Aujard
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D001424:Bacterial Infections / Q000635:transmission*; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013290:Streptococcal Infections / Q000175:diagnosis* / Q000517:prevention & control / Q000635:transmission*; D013292:Streptococcus agalactiae
chemical_list: D000900:Anti-Bacterial Agents