title: [Evaluation of reactogenicity and immunogenicity of Bubo-M, the Russian combined vaccine for immunization of adults against diphtheria, tetanus and viral hepatitis B].
abstract: Bubo-M, the first Russian associated vaccine, was found to have low reactogenicity and high immunogenic potency. The frequency of postvaccinal reactions in the group of persons immunized with Bubo-M (20%) appeared to be considerably lower than among persons who received the combined injection of adsorbed DT toxoid with reduced antigen content and vaccine against hepatitis B (47.7%). Following the course of vaccination the level of anti-HBs considerably exceeded the protective level. Immune response to the diphtheria and tetanus components of Bubo-M exceeded that observed after immunization with absorbed DT toxoid with reduced antigen content (p < 0.05).
authors.affiliation: Medical Academy, Perm, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Fel'dblium
authors.forename: N N
authors.initials: NN
authors.lastname: Vorob'eva
authors.forename: A M
authors.initials: AM
authors.lastname: Nikolaeva
authors.forename: V N
authors.initials: VN
authors.lastname: Borisova
authors.forename: V A
authors.initials: VA
authors.lastname: Mel'nikov
authors.forename: M V
authors.initials: MV
authors.lastname: Budanov
authors.forename: I A
authors.initials: IA
authors.lastname: Iakovleva
authors.forename: A V
authors.initials: AV
authors.lastname: Kaz'ianin
authors.forename: E V
authors.initials: EV
authors.lastname: Pushkareva
authors.forename: D V
authors.initials: DV
authors.lastname: Griaznova
authors.forename: N V
authors.initials: NV
authors.lastname: Shalunova
authors.forename: O V
authors.initials: OV
authors.lastname: Perelygina
authors.forename: N A
authors.initials: NA
authors.lastname: Ozeretskovskiĭ
authors.forename: T A
authors.initials: TA
authors.lastname: Bektimirov
authors.forename: N V
authors.initials: NV
authors.lastname: Isaeva
mesh_terms: D000293:Adolescent; D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology; D022422:Diphtheria-Tetanus Vaccine / Q000276:immunology*; D006511:Hepatitis B Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D012426:Russia; D014611:Vaccination / Q000009:adverse effects; D017778:Vaccines, Combined / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D022422:Diphtheria-Tetanus Vaccine; D006511:Hepatitis B Antigens; D017325:Hepatitis B Vaccines; D017778:Vaccines, Combined