title: Survival among U.S. women with invasive epithelial ovarian cancer.
abstract: OBJECTIVE
  Invasive epithelial ovarian cancer is a highly fatal disease, diagnosed at advanced stages when survival is poor. Relatively little is known about the variation in survival across U.S. women of different race/ethnicities. To investigate this issue, we evaluated pathological characteristics and death rates due to invasive epithelial ovarian cancer in a population-based sample of patients from six racial/ethnic groups.
  
  
  METHODS
  The analysis included 38,012 women diagnosed with primary invasive epithelial ovarian cancer between 1973 and 1997 in the Surveillance, Epidemiology and End Results Program of the National Cancer Institute.
  
  
  RESULTS
  Filipina patients were younger at diagnosis, more likely to have localized disease, and had more mucinous cancers than whites. African-Americans were more likely than whites to be diagnosed at older ages, with distant disease and with undifferentiated/unclassified cancers. After adjusting for age at diagnosis, stage of disease at diagnosis, and cancer histology, we found that, compared to whites, death rates were significantly elevated among African-Americans and significantly reduced among Hispanics and Filipina. We also found that death rates declined significantly with time since diagnosis among women with advanced disease.
  
  
  CONCLUSIONS
  The declining death rates in women with advanced disease suggest the presence of considerable prognostic heterogeneity among these women, which could reflect differences in quality of care. This issue, as well as the survival disadvantage for African-American women and survival advantages for Hispanic and Filipina women, needs investigation.
authors.affiliation: Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305-5405, USA. vmcguire@leland.stanford.edu
authors.forename: Valerie
authors.initials: V
authors.lastname: McGuire
authors.forename: Christine A
authors.initials: CA
authors.lastname: Jesser
authors.forename: Alice S
authors.initials: AS
authors.lastname: Whittemore
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004847:Epithelial Cells / Q000473:pathology; D005006:Ethnicity; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010051:Ovarian Neoplasms / Q000401:mortality* / Q000473:pathology; D018426:SEER Program; D015996:Survival Rate; D014481:United States / Q000453:epidemiology