The past, present and future of genome-wide re-annotation.
Annotation, the process by which structural or functional information is inferred for genes or proteins, is crucial for obtaining value from genome sequences. We define the process of annotating a previously annotated genome sequence as 're-annotation', and examine the strengths and weaknesses of current manual and automatic genome-wide re-annotation approaches.
Ouzounis
Christos A
CA
Bioinformatics Research Group, AI Center, SRI International, Menlo Park, CA 94025, USA. pkarp@ai.sri.com
Karp
Peter D
PD
D019295:Computational Biology / Q000592:standards / Q000639:trends*; D030541:Databases, Genetic / Q000592:standards / Q000639:trends; D030562:Databases, Protein / Q000592:standards / Q000639:trends; D016678:Genome; D011786:Quality Control