title: [An observation of the immuno-persistence after inoculating with the domestic BRD II strain rubella vaccine among infants and young children].
abstract: OBJECTIVE
  To study the immuno-persistence after inoculating with the domestic BRD II strain rubella vaccine among infants and young children.
  
  
  METHODS
  Hemagglutination inhibition (HI) antibody detection method was used to test on children at age 6 to 18 months without rubella infection or rubella vaccine immunization in Yantai city of Shandong province and were selected for the observation of the immuno-persistence against the domestic BRD II strain rubella vaccine from 1995 to 1998.
  
  
  RESULTS
  Positive rates of HI antibody among children of 6, 7, 8, 9, 12 and 18 month-old of inoculation were 94.44%, 97.22%, 96.67%, 100.00%, 100.00%, 100.00% and 93.10%, 93.55%, 96.77%, 96.97%, 100.00%, 100.00% (P > 0.05), in one or two years respectively. The geometric mean reverse titers (GMRTs) were about 50% lower than that after 1 month after 1 year. Similar results were found that after 2 years GMRTs was about 50% lower than that after 1 year of inoculation. There was highly significant difference on GMRTs of HI antibody between infants with 6 to 7 month-olds (29.89) and young children with 8 to 18 month-olds (53.00) after 2 years of inoculation (t = 3.58, P < 0.001).
  
  
  CONCLUSIONS
  The immunization schedule at the first dose for BRD II strain rubella vaccine should be started when the child is 8 month old. For the second dose, the immunization schedule used in other developed countries should be referred adopted in China.
authors.affiliation: Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014, China.
authors.forename: A
authors.initials: A
authors.lastname: Xu
authors.forename: L
authors.initials: L
authors.lastname: Song
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: A
authors.initials: A
authors.lastname: Wang
authors.forename: Q
authors.initials: Q
authors.lastname: Xu
authors.forename: Z
authors.initials: Z
authors.lastname: Xiao
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Hao
authors.forename: Z
authors.initials: Z
authors.lastname: Li
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D005500:Follow-Up Studies; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007223:Infant; D012411:Rubella Vaccine / Q000276:immunology*; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D012411:Rubella Vaccine