title: [The clinical effect of TS-1 in advanced and recurrent gastric cancer with peritoneal dissemination].
abstract: Eighteen patients with far advanced and recurrent gastric cancer with peritoneal dissemination were treated with a novel oral anticancer drug, TS-1, and assessed according to clinical effect. TS-1 was administered at a dose of 80-120 mg/day. One course consisted of consecutive administration of TS-1 for 28 days followed by 14 days rest. The 1- and 2-year survival rates and median survival time after administration of TS-1 were 63.2%, 23.7% and 437 days, respectively. Eight patients (44.4%) survived for 1 year or more. Adverse reactions consisted of reduction in hemoglobin level and hyperbilirubinemia at grades 3 and 4, which were observed in 3 patients and 1 patient, respectively. TS-1 is a promising drug for gastric cancer with peritoneal dissemination.
authors.affiliation: Dept. of Surgery, Yamagata Prefectural Kahoku Hospital.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Inaba
authors.forename: Shuichi
authors.initials: S
authors.lastname: Watabe
authors.forename: Shinya
authors.initials: S
authors.lastname: Ohe
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Kamio
authors.forename: Motoi
authors.initials: M
authors.lastname: Koyama
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Hayashi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Chiba
mesh_terms: D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000401:mortality; D010094:Oxonic Acid / Q000627:therapeutic use*; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000556:secondary*; D011725:Pyridines / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid