title: [Combined vaccine protecting from transmissible swine gastroenteritis].
abstract: An effective system for specific prevention of transmissive swine gastroenteritis (TSG) is based on the use of combined vaccine and combined vaccination. Combined vaccine is a lyophilized preparation for intranasal application and emulsion for intramuscular injection. The former is prepared from natural attenuated respiratory variant of TSG virus and the latter from artificially attenuated TSG virus. Combined vaccination consists in parallel double immunization of females on days 70-75 of gestation intramuscularly and intranasally and on days 90-95 of gestation intramuscularly. Vaccinal lactogenic immunity ensures protection of newborn piglets under experimental and field conditions (protection of 70-80 and 90-95% piglets, respectively). The proposed vaccine preparations and protocols of combined immunization of females during gestation by two methods are an effective and safe method for specific prevention of TSG.
authors.forename: T I
authors.initials: TI
authors.lastname: Aliper
authors.forename: V A
authors.initials: VA
authors.lastname: Sergeev
authors.forename: E A
authors.initials: EA
authors.lastname: Nepoklonov
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D017934:Coronavirus / Q000276:immunology*; D005260:Female; D005761:Gastroenteritis, Transmissible, of Swine / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D007112:Immunity, Maternally-Acquired; D007115:Immunization Schedule; D007124:Immunoenzyme Techniques; D007273:Injections, Intramuscular; D008892:Milk / Q000276:immunology; D009500:Neutralization Tests; D011247:Pregnancy; D013552:Swine; D014611:Vaccination / Q000379:methods*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines