title: Biology and significance of T-cell apoptosis in the liver.
abstract: The liver has emerged as an organ with distinct immunological properties. In this review, we summarize evidence that shows that the liver can remove apoptotic, or non-apoptotic but activated, CD8+ T cells from the circulation and induce apoptosis in these activated T cells by either active or passive mechanisms. Hepatitis viruses, particularly hepatitis C virus, often establish persistent infection. We review evidence that suggests that these viruses exploit intrahepatic tolerance mechanisms to protect themselves from immune attack.
authors.affiliation: The David H Smith Center for VaccineBiology and Immunology, The University of Rochester, Rochester, New York 14642, USA.
authors.forename: Sun
authors.initials: S
authors.lastname: Park
authors.forename: Debbie
authors.initials: D
authors.lastname: Murray
authors.forename: Beena
authors.initials: B
authors.lastname: John
authors.forename: I Nicholas
authors.initials: IN
authors.lastname: Crispe
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D016174:Hepacivirus / Q000276:immunology; D006801:Humans; D008099:Liver / Q000166:cytology / Q000276:immunology* / Q000821:virology