Prostaglandins as modulators of immunity.
Prostaglandins are potent lipid molecules that affect key aspects of immunity. The original view of prostaglandins was that they were simply immunoinhibitory. This review focuses on recent findings concerning prostaglandin E2 (PGE2) and the PGD2 metabolite 15-deoxy-Delta(12,14)-PGJ2, and their divergent roles in immune regulation. We will highlight how these two seminal prostaglandins regulate immunity and inflammation, and play an emerging role in cancer progression. Understanding the diverse activities of these prostaglandins is crucial for the development of new therapies aimed at immune modulation.
Harris
Sarah G
SG
Dept of Microbiology and the James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Padilla
Josue
J
Koumas
Laura
L
Ray
Denise
D
Phipps
Richard P
RP
D000276:Adjuvants, Immunologic / Q000502:physiology*; D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D018448:Models, Immunological; D008958:Models, Molecular; D009369:Neoplasms / Q000276:immunology; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000502:physiology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism
C097240:15-deoxy-delta(12,14)-prostaglandin J2; D000276:Adjuvants, Immunologic; D011451:Prostaglandin-Endoperoxide Synthases; D015232:Dinoprostone; D015230:Prostaglandin D2