[A study on the effects of CD3AK cells on the improvement of cellular immune function in burned patients].
OBJECTIVE
To explore new ways of correcting postburn immune suppression in severely burned patients.


METHODS
CD3AK cells were cultured in serum-free medium and were employed to treat patients with major burns. Similar patients treated by routine treatment were set to be control group. The changes of cellular immunological indices were dynamically observed in the patients of two groups at different time points.


RESULTS
Compared to those in control group, the ratio of CD4+ cell of T cell subgroup increased in patients treated by CD3AK, in concomitant with the decrease of the ratio of CD8+ cells and the increase of the ratio of CD4/CD8. Serum soluble IL-2R level decreased. T lymphocyte transforming activity increased and NK cell activity increased.


CONCLUSIONS
CD3AK cells cultured in serum-free medium could improve and restore the decreased cellular immune function in burn patients.
Zhan
J
J
Department of Burns, The First Affiliated Hospital of Jiang Xi Medical College, Nanchang 330006, Jiang Xi Province, P.R. China.
Li
G
G
Li
G
G
D000328:Adult; D002056:Burns / Q000097:blood / Q000276:immunology* / Q000628:therapy; D017252:CD3 Complex / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology; D016516:CD4-CD8 Ratio; D016827:CD8 Antigens / Q000276:immunology; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods; D007223:Infant; D007694:Killer Cells, Natural / Q000276:immunology*; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D015375:Receptors, Interleukin-2 / Q000097:blood; D013997:Time Factors; D016896:Treatment Outcome
D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D015375:Receptors, Interleukin-2