Safe administration of etoposide phosphate after hypersensitivity reaction to intravenous etoposide.
Etoposide is commonly used in a variety of malignancies. A well known but rare toxicity are hypersensitivity reactions, usually manifested by chest discomfort, dyspnoea, bronchospasm and hypotension. We report the details of a patient who developed hypersensitivity reactions to intravenous etoposide, but subsequently tolerated the administration of intravenous etoposide phosphate with no sequelae.
Siderov
J
J
Pharmacy Department, Austin & Repatriation Medical Centre, Studley Road, Heidelberg, Australia. jim.siderov@armc.org.au
Prasad
P
P
De Boer
R
R
Desai
J
J
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004342:Drug Hypersensitivity / Q000517:prevention & control*; D005047:Etoposide / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009943:Organophosphorus Compounds / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D009943:Organophosphorus Compounds; C061400:etoposide phosphate; D005047:Etoposide