title: Peptidomimetics of efflux pump inhibitors potentiate the activity of levofloxacin in Pseudomonas aeruginosa.
abstract: Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead, demonstrating that a peptide backbone is not essential for activity.
authors.affiliation: Essential Therapeutics, Inc., 850Maude Avenue, Mountain View, CA 94043, USA. trenau@etrx.com
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Renau
authors.forename: Roger
authors.initials: R
authors.lastname: Léger
authors.forename: Rose
authors.initials: R
authors.lastname: Yen
authors.forename: Miles W
authors.initials: MW
authors.lastname: She
authors.forename: Eric M
authors.initials: EM
authors.lastname: Flamme
authors.forename: Joan
authors.initials: J
authors.lastname: Sangalang
authors.forename: Carla L
authors.initials: CL
authors.lastname: Gannon
authors.forename: Suzanne
authors.initials: S
authors.lastname: Chamberland
authors.forename: Olga
authors.initials: O
authors.lastname: Lomovskaya
authors.forename: Ving J
authors.initials: VJ
authors.lastname: Lee
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001693:Biological Transport, Active / Q000187:drug effects; D004357:Drug Synergism; D064704:Levofloxacin; D049990:Membrane Transport Modulators; D026901:Membrane Transport Proteins / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D018716:Molecular Mimicry; D015394:Molecular Structure; D015242:Ofloxacin / Q000494:pharmacology*; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D049990:Membrane Transport Modulators; D026901:Membrane Transport Proteins; D010446:Peptide Fragments; D064704:Levofloxacin; D015242:Ofloxacin