[Effect of Rhaponticum carthamoides extract on hemorheological properties of blood in rats with arterial hypertension].
The hemorheological activity of a dry extract from Rhaponticum (Leuzea) carthamoides (Willd.) Iljin. was studied in spontaneously hypertensive rats (SHRs). A 14-day treatment of the test rats with a daily dose of 150 mg/kg improved the rheological characteristics, as manifested by a reduced viscosity of the whole blood and plasma, increased spontaneous erythrocyte aggregation and fibrinogen concentration, and increased erythrocyte deformability and electrophoretic mobility against the untreated control level.
Plotnikov
M B
MB
Laboratory of Circulatory, Tomsk Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
Aliev
O I
OI
Vasil'ev
A S
AS
Maslov
M Iu
MIu
Dmitruk
S E
SE
Krasnov
E A
EA
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002449:Cell Aggregation / Q000187:drug effects; D004586:Electrophoresis; D004907:Erythrocyte Deformability / Q000187:drug effects; D005340:Fibrinogen / Q000378:metabolism; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D012212:Rheology / Q000187:drug effects*
D000959:Antihypertensive Agents; D010936:Plant Extracts; D005340:Fibrinogen