Iridium-catalyzed H/D exchange into organic compounds in water.
The air-stable complex Cp(PMe(3))IrCl(2) efficiently catalyzes the exchange of deuterium from D(2)O into both activated and unactivated C-H bonds of organic molecules without added acid or stabilizers. Selectivity is observed in many cases, with activation of primary C-H bonds occurring preferentially. A number of new stoichiometric transformations involving the iridiym catalyst precursor are also presented, including an oxidation-decarbonylation reaction with primary alcohols.
Klei
Steven R
SR
Department of Chemistry and Center for New Directions in Organic Synthesis (CNDOS), University of California, 94720-1460, USA.
Golden
Jeffrey T
JT
Tilley
T Don
TD
Bergman
Robert G
RG