title: Is there a relationship between left ventricular systolic function and serum cytokines level in patients with coronary artery disease?
abstract: BACKGROUND
  There is growing evidence that cytokines play a pathogenic role in both heart failure and atherosclerosis. The aim of our study was to assess serum levels of selected cytokines and soluble forms of receptors in patients with coronary artery disease (CAD), and the relation between these concentrations and left ventricular (LV) systolic function.
  
  
  METHODS
  We measured serum levels of TNFalpha, sTNFR 1 and 2, IL-2, and IL-10 in 100 patients with CAD: 70 patients with LV regional wall motion disturbances (group A); and 30 patients with normal LV function (group B). The control group (group C) consisted of 20 healthy volunteers.
  
  
  RESULTS
  Mean serum TNFalpha and IL-10 concentrations were significantly higher in groups A (18.3 +/- 3.5; 55.4 +/- 118.5 pg/ml) and B (17.9 +/- 4.9; 45.3 +/- 76.8 pg/ml) than in controls (8.3 +/- 1.4, p<0.001; 14.3 +/- 28.5, p<0.05; respectively). Moreover, in group A serum levels of sTNFR 1 were higher (1367.4 +/- 531.1 pg/ml) than in group C (1093.9 +/- 456.9 pg/ml; p<0.05). No differences were found in the study groups between serum sTNFR 2 and IL-2 levels. In group A, both the LV ejection fraction and motion score index correlated with TNFalpha (r=-0.277; r=0.282; p<0.05), and sTNFR 1 levels (r=-0.258; r=0.280; p < 0.05).
  
  
  CONCLUSIONS
  The serum concentrations of TNFalpha and IL-10 are increased in patients with CAD. Additionally, patients with impaired LV contractility have higher sTNFR 1 concentrations. Serum cytokine activation may play a role in the development of heart failure in patients with CAD.
authors.affiliation: 2nd Department of Cardiology; Silesian University School of Medicine, ul. Ziołowa 45/47, 40-635 Katowice, Poland. biboch@slam.katowice.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Mizia-Stec
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Mandecki
authors.forename: Barbara
authors.initials: B
authors.lastname: Zahorska-Markiewicz
authors.forename: Joanna
authors.initials: J
authors.lastname: Janowska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Szulc
authors.forename: Ewa
authors.initials: E
authors.lastname: Jastrzebska-Maj
authors.forename: Leszek
authors.initials: L
authors.lastname: Szymański
mesh_terms: D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology*; D016207:Cytokines / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D016277:Ventricular Function, Left
chemical_list: D016207:Cytokines; D014280:Triglycerides; D002784:Cholesterol