title: Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4.
abstract: Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells. We show here that CD8+CD28(-) alloantigen-specific T suppressor (TS) cells induce the up-regulation of ILT3 and ILT4 on monocytes and dendritic cells, rendering these antigen-presenting cells (APCs) tolerogenic. Tolerogenic APCs show reduced expression of costimulatory molecules and induce antigen-specific unresponsiveness in CD4+ T helper cells. Studies of human heart transplant recipients showed that rejection-free patients have circulating TS cells, which induce the up-regulation of ILT3 and ILT4 in donor APCs. These findings demonstrate an important mechanism of immune regulation.
authors.affiliation: Department of Pathology, Columbia University, New York, NY 10032, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: Chang
authors.forename: R
authors.initials: R
authors.lastname: Ciubotariu
authors.forename: J S
authors.initials: JS
authors.lastname: Manavalan
authors.forename: J
authors.initials: J
authors.lastname: Yuan
authors.forename: A I
authors.initials: AI
authors.lastname: Colovai
authors.forename: F
authors.initials: F
authors.lastname: Piazza
authors.forename: S
authors.initials: S
authors.lastname: Lederman
authors.forename: M
authors.initials: M
authors.lastname: Colonna
authors.forename: R
authors.initials: R
authors.lastname: Cortesini
authors.forename: R
authors.initials: R
authors.lastname: Dalla-Favera
authors.forename: N
authors.initials: N
authors.lastname: Suciu-Foca
mesh_terms: D000938:Antigen-Presenting Cells / Q000737:chemistry / Q000502:physiology; D018106:CD28 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D003713:Dendritic Cells / Q000502:physiology*; D006801:Humans; D007108:Immune Tolerance; D008562:Membrane Glycoproteins; D016328:NF-kappa B / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D011971:Receptors, Immunologic / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D018106:CD28 Antigens; D016827:CD8 Antigens; C491341:LILRB2 protein, human; C107907:LILRB4 protein, human; D008562:Membrane Glycoproteins; D016328:NF-kappa B; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic