title: Effects of nicotine on the healing of extraction sockets in rats. A histological study.
abstract: The aim of the present study was to evaluate, histologically, the influence of nicotine on the socket healing after tooth extraction in rats. Eighty animals were divided into 4 groups of 20 rats each (2 control and 2 test groups). In the first and second test groups, the animals received one dose of nicotine hemisulfate solution once or twice daily, respectively. In the control groups, the animals received sterile saline once or twice daily. All solutions were injected subcutaneously on the dorsum of the animals for 4 weeks. The results showed that nicotine delayed alveolar healing, especially in terms of organization of connective tissue and osteoneogenesis. Angiogenesis was considerably impaired in the ossification area and in the gingival tissues as well. We concluded that the impairment of the healing of extraction sockets was found to be directly related to the drug dosage.
authors.affiliation: Department of Oral Medicine and Pediatric Dentistry, Faculty of Dentistry of Londrina, UEL, Londrina, PR, Brazil.
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Pinto
authors.forename: Alvaro Francisco
authors.initials: AF
authors.lastname: Bosco
authors.forename: Tetuo
authors.initials: T
authors.lastname: Okamoto
authors.forename: João Baptista
authors.initials: JB
authors.lastname: Guerra
authors.forename: Ivan Giácomo
authors.initials: IG
authors.lastname: Piza
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009538:Nicotine / Q000633:toxicity*; D018722:Nicotinic Agonists / Q000633:toxicity*; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D020390:Tooth Socket / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D018722:Nicotinic Agonists; D009538:Nicotine