[Cardioprotective effect of drugs with antioxidant activity in acute cerebral ischemia].
The bioelectric cardiac activity was studied in the experiments on white mice with an acute cerebral blood circulation disorder. It was found that he resulting EEG changes possess a specific character, with the sympathoadrenal system stimulation playing an important role in the acute cerebrocardiac syndrome development. The antioxidant-type agents such as emoxypine (50 mg/kg), mexidol (50 mg/kg), and cytochrome C (10 mg/kg) produce a significant cardioprotective effect in the test animals with experimental cerebral ischemia, which was comparable with the effect of propranolol (obsidane) (0.1 mg/kg).
Stoliarova
V V
VV
Department of Clinical Therapy, Mordvinian State University, ul. Bol'shevistskaya 68, Saransk, Mordvinia, 430000 Russia.
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002545:Brain Ischemia / Q000503:physiopathology / Q000517:prevention & control*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D003574:Cytochrome c Group / Q000494:pharmacology; D051379:Mice; D010847:Picolines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology
D000975:Antioxidants; D002316:Cardiotonic Agents; D003574:Cytochrome c Group; D010847:Picolines; C070020:emoxypine succinate; D011433:Propranolol; C009820:6-methyl-2-ethyl-3-hydroxypyridine