title: Cytokine-induced sickness behaviour: mechanisms and implications.
abstract: Sickness behaviour represents the expression of the adaptive reorganization of the priorities of the host during an infectious episode. This process is triggered by pro-inflammatory cytokines produced by peripheral phagocytic cells in contact with invading micro-organisms. The peripheral immune message is relayed to the brain via a fast neural pathway and a slower humoral pathway, resulting in the expression of pro-inflammatory cytokines in macrophage-like cells and microglia in the brain. The cellular and molecular components of this previously unsuspected system are being progressively identified. These advances are opening new avenues for understanding brain disorders, including depression.
authors.affiliation: Laboratory of Integrative Neurobiology, INRA-INSERM U 394, Rue Camille Saint-Saens, Bordeaux, France.
authors.forename: Jan Pieter
authors.initials: JP
authors.lastname: Konsman
authors.forename: Patricia
authors.initials: P
authors.lastname: Parnet
authors.forename: Robert
authors.initials: R
authors.lastname: Dantzer
mesh_terms: D000818:Animals; D000855:Anorexia / Q000276:immunology / Q000503:physiopathology; D001921:Brain / Q000276:immunology* / Q000503:physiopathology; D003141:Communicable Diseases / Q000276:immunology* / Q000503:physiopathology / Q000523:psychology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D003863:Depression / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007107:Immune System / Q000276:immunology* / Q000503:physiopathology; D012803:Sick Role; D015398:Signal Transduction / Q000276:immunology; D017833:Visceral Afferents / Q000276:immunology / Q000503:physiopathology
chemical_list: D016207:Cytokines