The effect of spray drying solutions of polyethylene glycol (PEG) and lactose/PEG on their physicochemical properties.
The effect of spray drying polyethylene glycol (PEG) 4000 and lactose/PEG solutions was investigated. Micro-spherical PEG particles were successfully prepared from ethanol, which allowed lower outlet temperatures than water. The product was crystalline and consisted of rough spheres or rod like particles. In the case of lactose/PEG composites, spray dried from water, the crystallinity of both components was reduced on spray drying, the extent being dependent on the starting composition. Spray dried lactose/PEG with PEG present as 10% by weight was found to be the most amorphous of the systems prepared. Conversion to more crystalline products occurred over time, the rates of conversion being dependent on temperature and humidity. On storage at low humidity (31-34%) amorphous lactose in lactose/PEG spray dried systems converts to anhydrous crystalline lactose while at high humidity (75% RH) the monohydrate is formed. The rate of transformation of amorphous lactose to the crystalline monohydrate form, at high relative humidity, was quantified using the Avrami equation applied both to X-ray diffraction (XRD) peak intensity and heat of fusion data. Crystallisation of lactose appeared to be retarded at low PEG concentrations, where PEG was present predominantly in a non-crystalline state, but was accelerated at higher PEG contents.
Corrigan
Deirdre O
DO
Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, Trinity College, 2, Dublin, Ireland. ocorrign@tcd.ie
Healy
Anne Marie
AM
Corrigan
Owen I
OI
D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003460:Crystallization; D007785:Lactose / Q000737:chemistry*; D019999:Pharmaceutical Solutions / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry
D019999:Pharmaceutical Solutions; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; D007785:Lactose