title: Nerve cell markers in ossifying fibromyxoid tumour of soft parts.
abstract: Reported herein are two benign ossifying fibromyxoid tumors (OFMTs) of the soft tissues in axilla and terminal phalanx respectively. Both cases on immunohistochemistry (IHC) showed reactivity for vimentin, S-100 protein and glial fibrillary acidic protein (GFAP) antibodies. In addition, a focal/diffuse strong positivity for neurofilament (NF) and neuron specific enolase (NSE) was observed. Electron microscopy in one instance revealed abundant intermediate filaments, primitive cell junctions and a focally present external lamina. In the light of nerve cell differentiation of these tumors and the similarity of IHC profile and EM features of OFMT to a poorly differentiated malignant peripheral nerve sheath tumor (MPNST); it is suggested that OFMT is a variably differentiated PNST rather than a simple Schwannian neoplasm as is believed.
authors.affiliation: Department of Pathology, BYL Nair Ch Hospital, Mumbai.
authors.forename: T
authors.initials: T
authors.lastname: Shet
authors.forename: S
authors.initials: S
authors.lastname: Desai
authors.forename: S
authors.initials: S
authors.lastname: Kane
authors.forename: I
authors.initials: I
authors.lastname: Vora
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D009999:Ossification, Heterotopic; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D014746:Vimentin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase