title: SCMTR: a chloride-selective, membrane-anchored peptide channel that exhibits voltage gating.
abstract: The design, synthesis, and characterization of a synthetic chloride membrane transporter, SCMTR (synthetic chloride membrane transporter, "scimitar"), are presented. The compound [CH3(CH2)17]2NCOCH2OCH2CO-GGGPGGG-OBzl inserts rapidly into liposomes and planar lipid bilayers. SCMTR has a 1.3 +/- 0.01 nS chloride diffusion pathway (>10:1 Cl/K selectivity). Evidence was also obtained for voltage gating behavior.
authors.affiliation: Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.
authors.forename: Paul H
authors.initials: PH
authors.lastname: Schlesinger
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ferdani
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Jolanta
authors.initials: J
authors.lastname: Pajewska
authors.forename: Robert
authors.initials: R
authors.lastname: Pajewski
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Saito
authors.forename: Hossein
authors.initials: H
authors.lastname: Shabany
authors.forename: George W
authors.initials: GW
authors.lastname: Gokel
mesh_terms: D018118:Chloride Channels / Q000138:chemical synthesis* / Q000737:chemistry; D015640:Ion Channel Gating; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D008564:Membrane Potentials; D010743:Phospholipids / Q000737:chemistry
chemical_list: D018118:Chloride Channels; D008051:Lipid Bilayers; D008081:Liposomes; D010743:Phospholipids