title: Clinical investigation of the lesions responsible for sensory disturbance in Minamata disease.
abstract: To clarify the lesions responsible for sensory disturbance in Minamata disease (MD), we clinically investigated the characteristics of sensory disturbance. In all patients with the classical type MD, two-point discrimination was severely disturbed, but the involvement of superficial sensation was relatively mild. On short-latency somatosensory evoked potential study, the component corresponding to N20 was completely absent with normal N9, N11, and N13 components. Although 14 of 38 chronic MD patients demonstrated intact superficial sensation, 10 of these 14 showed mild to moderate disturbance in two-point discrimination. The two-point discrimination in chronic MD patients was significantly high irrespective of the disturbance of superficial sensation. These findings suggest that the sensory disturbance of MD patients may mainly be caused by a lesion in the sensory cortex rather than in the peripheral nerves. However, other foci could be also responsible for the sensory impairment, since 9 of 38 chronic MD patients showed intact two-point discrimination.
authors.affiliation: Department of Neurology, Kumamoto University School of Medicine, Japan. uchino96@kaiju.medic.kumamoto-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Uchino
authors.forename: S
authors.initials: S
authors.lastname: Mita
authors.forename: H
authors.initials: H
authors.lastname: Satoh
authors.forename: T
authors.initials: T
authors.lastname: Hirano
authors.forename: K
authors.initials: K
authors.lastname: Arimura
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: E
authors.initials: E
authors.lastname: Uyama
authors.forename: Y
authors.initials: Y
authors.lastname: Ando
authors.forename: J
authors.initials: J
authors.lastname: Wakamiya
authors.forename: M
authors.initials: M
authors.lastname: Futatsuka
mesh_terms: D000328:Adult; D000368:Aged; D001259:Ataxia / Q000209:etiology; D004192:Discrimination, Psychological / Q000502:physiology*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D006801:Humans; D008297:Male; D020262:Mercury Poisoning, Nervous System / Q000145:classification / Q000473:pathology* / Q000503:physiopathology; D008875:Middle Aged; D011930:Reaction Time; D012016:Reference Values; D012678:Sensation Disorders / Q000209:etiology* / Q000503:physiopathology; D014794:Visual Fields