[The effects of NAC on the expression and activity of SPA in rats inflicted by smoke inhalation injury].
OBJECTIVE
To investigate the effects of NAC (N-acetyl-L-cysteine) on the expression and activity of SPA (surfactant-associated protein A) in rats inflicted by smoke inhalation injury.


METHODS
Wistar rats inflicted with smoke inhalation injury were employed as the model. The expression of SPA mRNA, the static pulmonary compliance, the surface tension of the alveolar lavage and the morphology of lamellae bodies (LB) of type II alveolar cells were examined.


RESULTS
After the application of NAC, there exhibited an increase in SPA mRNA expression and static pulmonary compliance, and the restoration of the BAL surface tension to normal.


CONCLUSIONS
The application of NAC could promote the expression of SPA mRNA after smoke inhalation injury and improve the SPA-related function.
Fu
Z
Z
Department of Respiratory Disease, Wu Han General Hospital of Guang Zhou Military Region, Wu Han 430070, P.R. China.
Yang
Z
Z
Li
A
A
D000111:Acetylcysteine / Q000627:therapeutic use*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D008170:Lung Compliance; D011510:Proteolipids / Q000235:genetics* / Q000502:physiology; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants / Q000235:genetics* / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D015208:Smoke Inhalation Injury / Q000188:drug therapy* / Q000503:physiopathology; D013500:Surface Tension
D011510:Proteolipids; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants; D012333:RNA, Messenger; D000111:Acetylcysteine