[A study of cytokines in pathogenesis of thyroid-related immune orbitopathy].
OBJECTIVE
To explore the pathogenesis of thyroid-related immune orbitopathy (TRIO).


METHODS
Human orbital fibroblasts were cultured in vitro and immunohistochemical techniques were used to study cytokines that induce effect on HLA-II antigen expression of orbital fibroblasts.


RESULTS
It is shown that interferon-gamma (IFN-gamma), interleukin-1 (IL-1) and tumor necrosis factor (TNF) could induce the expression of orbital fibroblast HLA-II antigens. The induced effect of IFN-gamma is of good linear correlations with time and concentration.


CONCLUSIONS
HLA-II antigen expression can be induced by IFN-gamma, IL-1 and TNF. In the course of immune reaction and pathogenesis of TRIO, cytokines play important roles.
Sun
F
F
Department of Ophthalmology, Second Hospital of Tianjin Medical University, Tianjin 300211.
Zhao
H
H
Song
G
G
Pan
Y
Y
Zhang
S
S
Chang
J
J
D016207:Cytokines / Q000502:physiology*; D006111:Graves Disease / Q000209:etiology*; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology; D007375:Interleukin-1 / Q000502:physiology; D009916:Orbital Diseases / Q000209:etiology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D016207:Cytokines; D000949:Histocompatibility Antigens Class II; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma