title: Comparison of brainstem auditory evoked responses recorded at different presentation rates of clicks in term neonates after asphyxia.
abstract: This study examined whether high presentation rates of clicks while recording brainstem auditory evoked responses (BAER) can improve the detection of central auditory impairment in asphyxiated neonates using the BAER. The BAER was analysed at different presentation rates of clicks within the first week after birth in 38 term neonates who suffered perinatal asphyxia. At the routinely used 21 s(-1) clicks all BAER wave latencies increased significantly (ANOVA, p < 0.05-0.01). After excluding five neonates who had a significantly elevated BAER threshold, only wave V latency increased slightly (p < 0.05). The interpeak intervals of I-V and III-V also increased slightly (both p < 0.05). Similar results were found at 51 s(-1) clicks. As the clicks were increased to 91 s(-1), the III-V interval increased more significantly (p < 0.01) and the III-V/I-III interval ratio also increased significantly (p < 0.01). In particular, wave V amplitude reduced more significantly than that in normal term controls (p < 0.01). Compared with values in the controls, wave V amplitude reduced by 4.5%, 12.2% and 24.7% at 21, 51 and 91 s(-1) clicks, respectively.
  
  
  CONCLUSIONS
  Although a moderate increase in the rate (e.g. 51 s(-1)) while recording the BAER did not improve the detection of hypoxic-ischaemic auditory impairment, a significant increase (e.g. 91 s(-1)) did, which mainly indicates an abnormal reduction in wave V amplitude.
authors.affiliation: Department of Paediatrics, John Radcliffe Hospital, University of Oxford, Headington, UK. jiang.zedong@paediatrics.ox.ac.uk
authors.forename: Z D
authors.initials: ZD
authors.lastname: Jiang
authors.forename: D M
authors.initials: DM
authors.lastname: Brosi
authors.forename: A R
authors.initials: AR
authors.lastname: Wilkinson
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications* / Q000503:physiopathology*; D001304:Auditory Diseases, Central / Q000209:etiology* / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011930:Reaction Time / Q000502:physiology; D012680:Sensitivity and Specificity; D013997:Time Factors