Early follicular serum müllerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles.
OBJECTIVE
To test the hypothesis that the concentration of early follicular phase serum müllerian-inhibiting substance (MIS) is associated with ovarian response in women undergoing ovulation induction in preparation for assisted reproductive technology (ART).


METHODS
Retrospective analysis of frozen day 3 serum samples.


METHODS
Academic ART program.


METHODS
One sample of frozen day 3 serum from women with < or = 6 retrieved oocytes (n = 28) compared with women with > or = 11 oocytes retrieved (n = 79) in preparation for IVF.


METHODS
None.


METHODS
Comparison of day 3 serum MIS levels between two groups of women. Other comparisons included maximum serum E(2) concentrations, number of retrieved oocytes, and percentage of mature oocytes between groups.


RESULTS
Mean serum MIS concentrations were 1.0 +/- 0.4 ng/mL compared with 2.5 +/- 0.3 ng/mL, or more than a 2.5-fold greater serum concentration of MIS in the group with > or = 11 oocytes retrieved compared with in the group with < or = 6 retrieved oocytes.


CONCLUSIONS
These data demonstrate an association between early follicular phase serum MIS and the number of retrieved oocytes. Higher day 3 serum MIS concentrations were associated with greater number of retrieved oocytes.
Seifer
David B
DB
Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Reproductive Endocrinology and Infertility, UMDNJ--Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA. seiferb@umdnj.edu
MacLaughlin
David T
DT
Christian
Benjamin P
BP
Feng
Bo
B
Shelden
Robert M
RM
D000328:Adult; D054304:Anti-Mullerian Hormone; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005498:Follicular Phase; D006023:Glycoproteins; D006131:Growth Inhibitors / Q000096:biosynthesis / Q000097:blood*; D006801:Humans; D009865:Oocytes / Q000502:physiology; D010053:Ovary / Q000502:physiology*; D010062:Ovulation Induction; D012189:Retrospective Studies; D013735:Testicular Hormones / Q000096:biosynthesis / Q000097:blood*
D006023:Glycoproteins; D006131:Growth Inhibitors; D013735:Testicular Hormones; D004958:Estradiol; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone