[Diagnostic significance of albumin transporting characteristics and blood level of troponin T in myocardial infarction].
Serum albumin binding capacity (ABC) was studied using K-35 hydrophobic fluorescent probe in order evaluate the passive transfer and absorption of saturated fatty acids (s-FA) by the cells. ABC decreases on day 3 of myocardial infarction and remains low till discharge and is paralleled by hyperTG. We believe that ABC decrease reflects activation of passive transfer and absorption of s-FA by the cells during simultaneous blocking (presumably by acute phase proteins) of active apoE/B-100 receptor endocytosis of s-FA in the form of TG as VLDL remnants. Decrease of ABC reflects a later than erythrocyte sedimentation rate and acute phase proteins normalization of metabolic consequences of inflammation. ABC helps indirectly evaluate the blocking of active (receptor) absorption of s-FA in the form of TG and activation of passive absorption of s-FA from associations with albumin by the cells.
Titov
V N
VN
Staroverov
I I
II
Ameliushkina
V A
VA
Gryzunov
Iu A
IuA
Filipenko
M B
MB
Tvorogova
M G
MG
Dobretsov
G E
GE
D000368:Aged; D015415:Biomarkers; D005456:Fluorescent Dyes; D006801:Humans; D008024:Ligands; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011485:Protein Binding; D012709:Serum Albumin / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D020107:Troponin T / Q000097:blood*
D015415:Biomarkers; D005456:Fluorescent Dyes; D008024:Ligands; D012709:Serum Albumin; D020107:Troponin T