[Effect of quinine and quinidine on the status of hematopoietic and lymphoid organs].
The effect of quinine and quinidine introduction in subtoxic doses on the characteristics of the hemopoietic and lymphoid organs was studied in BALB/c mice. The treatment led to reversible anemia and neutrophile leukocytosis in peripheral blood. There was a tendency to the early decrease in neutrophiles the late decrease in lymphocytes in the bone marrow. The quinine-induced decrease in erythrocytes was accompanied by reticulosis, lowered erythrocyte osmoresistance, and intensified spleen erythropoiesis; quinidine induced reticulocytopenia and a decrease in the bone narrow erythroblasts. The use of both compounds was accompanied by a decrease in thymus weight and increase in the thymocyte loss in the early period, followed by the spleen weight increase in the long term.
Karpova
G V
GV
Tomsk Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
Berchuk
T Iu
TIu
Abramova
E V
EV
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D008221:Lymphoid Tissue / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D011802:Quinidine / Q000494:pharmacology*; D011803:Quinine / Q000494:pharmacology*
D011803:Quinine; D011802:Quinidine