Dermatomyositis sine myositis and antisynthetase syndrome.
We describe a 66-year-old woman with cutaneous lesions typical of classic dermatomyositis, clinical evidence of antisynthetase syndrome (arthritis, Raynaud's phenomenon, mechanic's hands and interstitial lung disease with anti-Jo-1 autoantibody) and lack of muscle disease after a full muscle evaluation that included clinical, enzymatic, electromyographic, magnetic resonance imaging and histological studies. The patient did not develop myositis after 9 years of clinical disease. The association of dermatomyositis sine myositis with antisynthetase antibodies suggests that the characteristic skin lesions are closely linked with dermatomyositis on the basis of the similar clinical and serological features of both dermatomyositis sine myositis and classic dermatomyositis.
Climent-Albaladejo
Ana
A
Rheumatology unit, Hospital General Universitario Morales Meseguer, Murcia, Spain. Zuniga@um.es
Saiz-Cuenca
Encarnacion
E
Rosique-Roman
Juan
J
Caballero-Rodriguez
Julian
J
Galvez-Munoz
Jose
J
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000276:immunology; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001168:Arthritis / Q000276:immunology / Q000473:pathology*; D002738:Chloroquine / Q000627:therapeutic use; D003882:Dermatomyositis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000276:immunology / Q000473:pathology*; D009220:Myositis / Q000276:immunology / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use; D011928:Raynaud Disease / Q000276:immunology / Q000473:pathology*; D013577:Syndrome; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000974:Antibodies, Antinuclear; D018501:Antirheumatic Agents; C046750:Jo-1 antibody; D002738:Chloroquine; D011241:Prednisone