[A study on the prevention of selenite cataract with taurine].
OBJECTIVE
To evaluate the prevention of selenite cataract with taurine.


METHODS
A prior injection of taurine was given intraperitoneally to Wistar rats 2 days before the selenite challenge and a following daily injection of taurine was needed until the experiment was finished. All of the rats were examined under a split-lamp microscope on selected days.


RESULTS
0.5% taurine showed no effect on lenses, 1%, 2% and 4% taurine could delay the development of nuclear opacity, and 2% and 4% taurine could also delay the development of cortical opacity.


CONCLUSIONS
Taurine can prevent the development of selenite cataract. Its effect is dose-dependent.
Zhang
W
W
Beijing Institute of Ophthalmology, Beijing 100730.
Chen
C
C
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002386:Cataract / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite / Q000633:toxicity*; D013654:Taurine / Q000627:therapeutic use*
D013654:Taurine; D018038:Sodium Selenite