title: Involvement of the suprachiasmatic nucleus in body temperature modulation by food deprivation in rats.
abstract: Recently we found that food-deprived rats kept under a light-dark cycle showed a progressive reduction in body temperature during the light phase on each subsequent day while body temperature in the dark phase did not differ from baseline values. In this study, we investigated the effect of lesioning the hypothalamic suprachiasmatic nucleus (SCN) on body temperature modulation by food deprivation. In the SCN-lesioned rats in which daily rhythms of body temperature and activity were abolished, body temperature was unchanged by food deprivation. We also examined the effect of food deprivation on the daily changes in Fos expression in the SCN. Under normal fed conditions the number of SCN cells expressing Fos is high during the day and low at night. Food deprivation attenuated the amplitude of this daily change in Fos expression in the SCN. This tendency was prominent in the dorsal part of the SCN, while the ventral part showed no effect of food deprivation. These findings suggest that the SCN plays some role in body temperature modulation due to food deprivation.
authors.affiliation: Department of Physiology and Biosignalling, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan.
authors.forename: Su
authors.initials: S
authors.lastname: Liu
authors.forename: Xiao Ming
authors.initials: XM
authors.lastname: Chen
authors.forename: Tamae
authors.initials: T
authors.lastname: Yoda
authors.forename: Kei
authors.initials: K
authors.lastname: Nagashima
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kanosue
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D015536:Down-Regulation / Q000502:physiology; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010775:Photic Stimulation; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013493:Suprachiasmatic Nucleus / Q000166:cytology / Q000378:metabolism* / Q000601:surgery; D015854:Up-Regulation / Q000502:physiology
chemical_list: D016760:Proto-Oncogene Proteins c-fos