title: Application of the "VARICOL" process to the separation of the isomers of the SB-553261 racemate.
abstract: A new continuous chromatographic process (VARICOL) has been presented recently. The basic principle of the new VARICOL process consists of an asynchronous shift of the inlet/outlet lines in a multi-column system on a recycle loop. This process has been used to perform the separation of the optical isomers of the SB-553261 racemate. In this paper, we illustrate that for this specific separation, the VARICOL process is more efficient than the well-known SMB process.
authors.affiliation: NOVASEP SAS, Site Eiffel, Pompey, France. olivier_ludemann-hombourger@novasep.com
authors.forename: O
authors.initials: O
authors.lastname: Ludemann-Hombourger
authors.forename: G
authors.initials: G
authors.lastname: Pigorini
authors.forename: R M
authors.initials: RM
authors.lastname: Nicoud
authors.forename: D S
authors.initials: DS
authors.lastname: Ross
authors.forename: G
authors.initials: G
authors.lastname: Terfloth
mesh_terms: D002845:Chromatography / Q000295:instrumentation / Q000379:methods*; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D006574:Heterocyclic Compounds, 2-Ring; C464580:SB-553261