title: Enantioseparations in nonaqueous capillary liquid chromatography and capillary electrochromatography using cellulose tris(3,5-dimethylphenylcarbamate) as chiral stationary phase.
abstract: The potential of the widely used chiral stationary phase for high-performance liquid chromatography (HPLC) enantioseparations, cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC, sold under the trade name Chiralcel OD) was evaluated under the conditions of nonaqueous capillary electrochromatography (CEC). The effect of the particle size of the silica gel, the loading of CDMPC on the silica gel and nature of the organic solvent, as well as electrolyte salts on the separation characteristics were investigated. This study illustrates the applicability of CDMPC for obtaining highly efficient enantioseparations under the conditions of nonaqueous CEC. Comparative study of enantioseparations in capillary liquid chromatography (CLC) and CEC indicated the significant advantages of CEC such as higher plate number at the similar linear flow rates of the mobile phase as well as better tolerance of higher linear flow rates.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Nagoya, Japan.
authors.forename: Lali
authors.initials: L
authors.lastname: Chankvetadze
authors.forename: Irma
authors.initials: I
authors.lastname: Kartozia
authors.forename: Chiyo
authors.initials: C
authors.lastname: Yamamoto
authors.forename: Bezhan
authors.initials: B
authors.lastname: Chankvetadze
authors.forename: Gottfried
authors.initials: G
authors.lastname: Blaschke
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Okamoto
mesh_terms: D002219:Carbamates / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004573:Electrolytes; D019075:Electrophoresis, Capillary / Q000379:methods*; D015394:Molecular Structure; D048448:Phenylcarbamates; D012822:Silicon Dioxide
chemical_list: D002219:Carbamates; D004573:Electrolytes; D048448:Phenylcarbamates; C065943:cellulose tris-3,5-dimethylphenyl-carbamate; D012822:Silicon Dioxide; D002482:Cellulose