title: Marginal donor lungs: a reassessment.
abstract: OBJECTIVE
  Lung transplantation is limited by the shortage of suitable donors. To overcome this problem, many programs have begun to use marginal or extended donors after reports suggesting equivalent outcomes with no additional risk. As our use of extended donor lungs increased and our recipient selection criteria expanded, we believed it was appropriate to reevaluate outcomes with extended donor lungs compared with outcomes with standard donor lungs and recipients outside of the currently accepted guidelines.
  
  
  METHODS
  We performed a retrospective review of 128 consecutive lung or heart-lung transplants from January 1, 1997, to June 30, 2000. The primary endpoint was 30-day mortality. Donors were considered extended if any one of the following criteria were met: age greater than 55 years, smoking longer than 20 pack-years, presence of chest radiographic film infiltrate, PO (2) of less than 300 mm Hg, or purulent secretions on bronchoscopy. Guideline and nonguideline recipients were defined on the basis of previously published criteria.
  
  
  RESULTS
  Of a total of 123 donors, 63 (51%) were extended. Forty-eight donors failed 1 criterion, 10 failed 2 criteria, and 5 failed 3 criteria. One hundred twenty-eight transplants were performed. The 30-day mortality for the standard donor group was 4 (6.2%) of 65 versus 11 (17.5%) of 63 for the extended donor group (P =.047).
  
  
  CONCLUSIONS
  Although many extended donor lungs will result in acceptable postoperative function, caution needs to be exercised in the uses of certain extended donor lungs because there seems to be an increased early mortality rate in that group of recipients. Nonguideline recipients appear to have acceptable early mortality, except when they received extended donor lungs.
authors.affiliation: Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, 200 Elizabeth Street, EN 10-224, Toronto, Ontario M5G 2C4, Canada.
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Pierre
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sekine
authors.forename: Michael A
authors.initials: MA
authors.lastname: Hutcheon
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Waddell
authors.forename: Shaf H
authors.initials: SH
authors.lastname: Keshavjee
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D016041:Heart-Lung Transplantation; D006801:Humans; D016040:Lung Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D014019:Tissue Donors; D016896:Treatment Outcome