title: Anti-inflammatory efficacy of topical preparations with 10% hamamelis distillate in a UV erythema test.
abstract: In 40 volunteers the efficacy of three lotions with 10% hamamelis distillates from different suppliers, two vehicles, dimethindene maleate 0.1% gel, hydrocortisone 1% cream and hydrocortisone 0.25% lotion were investigated in a modified UV erythema test with three UV dosages (1.2, 1.4 and 1.7 MED). The test preparations were applied occlusively over a 48-hour period following irradiation. Chromametric measurement of redness and visual assessment were performed 24, 48 and 72 h after induction of erythema. The hydrocortisone formulations were most effective in erythema suppression. An anti- inflammatory effect was noted for all three hamamelis lotions as well as for the vehicles. A significantly greater suppression of erythema than seen with the vehicles was noted for one of the hamamelis lotions at 1.4 MED. The efficacy of the antihistamine dimethindene maleate did not surpass the hamamelis lotions or the vehicles. Even though the differences between the hamamelis lotions were slight, it was possible to make an objective selection of the best hamamelis distillate for aftersun purposes.
authors.affiliation: BioSkin Institute for Dermatological Research and Development GmbH, Hamburg, 22399, Germany. bhughes@bioskin.de
authors.forename: B J
authors.initials: BJ
authors.lastname: Hughes-Formella
authors.forename: A
authors.initials: A
authors.lastname: Filbry
authors.forename: J
authors.initials: J
authors.lastname: Gassmueller
authors.forename: F
authors.initials: F
authors.lastname: Rippke
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004115:Dimethindene; D004311:Double-Blind Method; D004890:Erythema / Q000188:drug therapy*; D005260:Female; D029501:Hamamelis; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D013471:Sunburn / Q000188:drug therapy; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006634:Histamine H1 Antagonists; D010936:Plant Extracts; D004115:Dimethindene; D006854:Hydrocortisone