title: A genomic regulatory network for development.
abstract: Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. davidson@caltech.edu
authors.forename: Eric H
authors.initials: EH
authors.lastname: Davidson
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Rast
authors.forename: Paola
authors.initials: P
authors.lastname: Oliveri
authors.forename: Andrew
authors.initials: A
authors.lastname: Ransick
authors.forename: Cristina
authors.initials: C
authors.lastname: Calestani
authors.forename: Chiou-Hwa
authors.initials: CH
authors.lastname: Yuh
authors.forename: Takuya
authors.initials: T
authors.lastname: Minokawa
authors.forename: Gabriele
authors.initials: G
authors.lastname: Amore
authors.forename: Veronica
authors.initials: V
authors.lastname: Hinman
authors.forename: Cesar
authors.initials: C
authors.lastname: Arenas-Mena
authors.forename: Ochan
authors.initials: O
authors.lastname: Otim
authors.forename: C Titus
authors.initials: CT
authors.lastname: Brown
authors.forename: Carolina B
authors.initials: CB
authors.lastname: Livi
authors.forename: Pei Yun
authors.initials: PY
authors.lastname: Lee
authors.forename: Roger
authors.initials: R
authors.lastname: Revilla
authors.forename: Alistair G
authors.initials: AG
authors.lastname: Rust
authors.forename: Zheng jun
authors.initials: Zj
authors.lastname: Pan
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Schilstra
authors.forename: Peter J C
authors.initials: PJ
authors.lastname: Clarke
authors.forename: Maria I
authors.initials: MI
authors.lastname: Arnone
authors.forename: Lee
authors.initials: L
authors.lastname: Rowen
authors.forename: R Andrew
authors.initials: RA
authors.lastname: Cameron
authors.forename: David R
authors.initials: DR
authors.lastname: McClay
authors.forename: Leroy
authors.initials: L
authors.lastname: Hood
authors.forename: Hamid
authors.initials: H
authors.lastname: Bolouri
mesh_terms: D000818:Animals; D019070:Cell Lineage; D019295:Computational Biology; D047108:Embryonic Development; D004707:Endoderm / Q000166:cytology / Q000502:physiology*; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D005809:Genes, Regulator; D016678:Genome; D008648:Mesoderm / Q000166:cytology / Q000502:physiology*; D008954:Models, Biological; D008957:Models, Genetic; D009024:Morphogenesis; D012045:Regulatory Sequences, Nucleic Acid; D012617:Sea Urchins / Q000196:embryology* / Q000235:genetics*; D013234:Stem Cells / Q000502:physiology; D013598:Systems Theory