[T cell and molecule-1 detection in cornea of fetus, neonates, children and adults].
OBJECTIVE
To study the immune state of human cornea with different ages.


METHODS
The human corneas in different ages were detected by using immunohistochemical techniques for 5 types of monoclonal antibody.


RESULTS
The contents of T-cell (CD(+)(3)), helper/inducer (CD(+)(4)), toxic T-cell (CD(+)(8)), macrophage (CD(+)(68)) and molecule-1 (intercellular adhesive molecule, CD(+)(54)) in the adult cornea were relatively low, mainly in the limbus but none at the corneal center. These positive cells were less in corneas of fetus, neonates and children than that in adults.


CONCLUSIONS
In corneas of fetus, neonates and children, the T-cell, macrophage and molecule-1 were less than that of adults. Their corneas may be used as donors in corneal transplantation.
Jia
H
H
Department of Ophthalmology, Third Hospital of Bethune Medical University, Changchun 130031, China.
Du
H
H
Pei
Y
Y
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000737:chemistry* / Q000196:embryology / Q000254:growth & development; D005260:Female; D005333:Fetus; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D018799:Intercellular Adhesion Molecule-1; C067980:CD68 antigen, human; D000097382:CD68 Molecule