[Cytotoxic natural killer/T-cell lymphomas of the lymph nodes].
OBJECTIVE
To investigate the clinicopathologic features of cytotoxic natural killer (NK)/T-cell lymphomas of the lymph nodes.


METHODS
Clinicopathologic observations and follow up on 5 cases of cytotoxic NK/T-cell lymphomas of the lymph nodes, immunohistochemical staining for CD45RO, CD8, CD56, CD30, CD20, TIA-1 and in situ hybridization for EBER1/2 were performed.


RESULTS
(1) The clinicopathologic features of cytotoxic NK-T-cell lymphomas of the lymph nodes were summarized; (2) The tumor cells were positive for CD45RO in 4 of the 5 cases, in which 3 cases were also positive for CD56. One case was of null cell type. The tumor cells were positive for TIA-1 and EBER1/2 in all 5 cases.


CONCLUSIONS
The clinicopathological features and special immunophenotypes of cytotoxic NK/T-cell lymphomas of the lymph nodes were present in all 5 cases. Clinically, this entity tends to be an aggressive process with poor prognosis.
Lin
T
T
Department of Pathology, First University Hospital, West-China University of Medical Sciences, Chengdu 610041, China.
Liu
W
W
Li
G
G
Li
F
F
Yuan
J
J
D000328:Adult; D000368:Aged; D019002:CD56 Antigen / Q000378:metabolism; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology*; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009666:Nose / Q000473:pathology; D009669:Nose Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D039102:Poly(A)-Binding Proteins; D011379:Prognosis; D011506:Proteins / Q000378:metabolism; D012367:RNA, Viral / Q000378:metabolism; D016601:RNA-Binding Proteins; D000074019:T-Cell Intracellular Antigen-1
D019002:CD56 Antigen; C099537:Epstein-Barr virus encoded RNA 1; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human; D017493:Leukocyte Common Antigens