title: Retronasal transport of aroma compounds.
abstract: A comparison was made between the amounts of volatiles in the headspace above a solution and the breath volatile content (exhaled from the nose or mouth) after consumption of the same solution. The amounts of volatiles in the breath were lower than those in the headspace, with breath exhaled via the mouth containing, on average, 8-fold more volatiles than breath exhaled via the nose. Dilution of the sample by saliva in-mouth did not appear to be a major factor affecting volatile delivery. Instead, the rate of in vivo equilibration (mass transfer) appeared to be the most significant factor, principally affecting volatile delivery from the solution to the gas phase. Thereafter, gas-phase dilution of the volatile as it passed through the upper airway resulted in a further decrease in volatile concentration. The final factor affecting the volatile concentration exhaled from the nose was absorption of volatiles to the nasal epithelia, which was greatest for those compounds with the lowest air/water partition coefficients.
authors.affiliation: School of Biosciences, Division of Food Sciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, U.K. robert.linforth@nottingham.ac.uk
authors.forename: Rob
authors.initials: R
authors.lastname: Linforth
authors.forename: Fiona
authors.initials: F
authors.lastname: Martin
authors.forename: Michelle
authors.initials: M
authors.lastname: Carey
authors.forename: Jim
authors.initials: J
authors.lastname: Davidson
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Taylor
mesh_terms: D000096:Acetone; D006801:Humans; D009666:Nose / Q000502:physiology*; D009812:Odorants / Q000032:analysis*; D012044:Regression Analysis; D015656:Respiratory Mechanics / Q000502:physiology; D012463:Saliva / Q000737:chemistry; D013649:Taste / Q000502:physiology*
chemical_list: D000096:Acetone