title: Randomized prospective double-blind placebo-controlled trial of effect of intravenous ondansetron on intraocular pressure during ophthalmic surgery.
abstract: The effect of i.v. ondansetron, before induction of anaesthesia, on intraocular pressure (IOP) in patients undergoing cataract surgery was investigated. Forty patients (two groups of 20) received either ondansetron 4 mg (treatment group) or 0.9% saline (placebo group) in a double-blind controlled manner. There were no significant differences in IOP between the groups. Ondansetron had no significant effect on IOP during the study period.
authors.affiliation: Department of Anaesthesia, Royal Liverpool University Hospital, UK.
authors.forename: N M
authors.initials: NM
authors.lastname: Robin
authors.forename: S M
authors.initials: SM
authors.lastname: Mostafa
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000932:Antiemetics / Q000494:pharmacology*; D002387:Cataract Extraction; D004311:Double-Blind Method; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007432:Intraoperative Period; D008875:Middle Aged; D017294:Ondansetron / Q000494:pharmacology*; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D011229:Preanesthetic Medication; D011446:Prospective Studies
chemical_list: D000932:Antiemetics; D017294:Ondansetron