Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand.
A combined analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in Seveso adults and Ranch Hand veterans found a period of fast elimination within the first 0.27 years after exposure in Seveso, followed by a period of slower elimination between 3 and 16.35 years from exposure. The mean TCDD elimination rate within the first 0.27 years after exposure among six adult males in the Seveso cohort was 2.0646 year(-1) (half-life=0.34 years). The mean rate from 3 to 16.35 years was 0.1011 year(-1) (half-life=6.9 years). The mean Ranch Hand elimination rate, 00924 year(-1) (half-life=6.9 years), measured between 9 and 33 years after exposure, was significantly less than the Seveso mean in the first 0.27 years after exposure, but not significantly different from the Seveso mean between 3 and 16.35 years after exposure. The fast elimination within the first 0.27 years followed by a slower rate after 3 years is consistent with the expected pattern in a two-compartment open model, with a distribution phase of rapid elimination followed by a slower elimination phase.
Michalek
Joel E
JE
Air Force Research Laboratory, Brooks Air Force Base, San Antonio, Texas 78235-5250, USA. joel.michalek@brooks.af.mil
Pirkle
James L
JL
Needham
Larry L
LL
Patterson
Donald G
DG
Caudill
Samuel P
SP
Tripathi
Ram C
RC
Mocarelli
Paolo
P
D000062:Accidents, Occupational / Q000706:statistics & numerical data; D000328:Adult; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008657:Metabolic Clearance Rate; D016273:Occupational Exposure / Q000032:analysis*; D000072317:Polychlorinated Dibenzodioxins / Q000493:pharmacokinetics*; D017678:Sex Distribution; D013997:Time Factors; D014481:United States; D014728:Veterans
D000072317:Polychlorinated Dibenzodioxins