title: Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine.
abstract: Here we report the identification of inbred miniature swine that failed to produce human-tropic replication-competent porcine endogenous retroviruses (HTRC PERVs), using in vitro coculture assays. When HTRC PERVs were isolated from transmitting animals, all were recombinant viruses, with the receptor-binding domain of PERV-A combining with PERV-C-related sequences.
authors.affiliation: Immerge BioTherapeutics, Inc., Charlestown, Massachusetts02129, USA.
authors.forename: Beth A
authors.initials: BA
authors.lastname: Oldmixon
authors.forename: James C
authors.initials: JC
authors.lastname: Wood
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Ericsson
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Wilson
authors.forename: Mary E
authors.initials: ME
authors.lastname: White-Scharf
authors.forename: Goran
authors.initials: G
authors.lastname: Andersson
authors.forename: Julia L
authors.initials: JL
authors.lastname: Greenstein
authors.forename: Henk-Jan
authors.initials: HJ
authors.lastname: Schuurman
authors.forename: Clive
authors.initials: C
authors.lastname: Patience
mesh_terms: D000818:Animals; D017849:Animals, Inbred Strains; D001483:Base Sequence; D002460:Cell Line; D002478:Cells, Cultured; D018920:Coculture Techniques; D020077:Endogenous Retroviruses / Q000235:genetics* / Q000502:physiology*; D015752:Genes, env; D006801:Humans; D007963:Leukocytes, Mononuclear; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D013556:Swine, Miniature / Q000821:virology*; D014779:Virus Replication