Potassium release, a useful tool for studying antimicrobial peptides.
We used an ion-selective electrode to measure potassium release from bacteria treated with antimicrobial peptides. This broadly applicable and simple technique for assessing membrane integrity deserves greater use.
Orlov
Dmitri S
DS
Department of Medicine, UCLA Center for Health Sciences, 10833 LeConte Avenue, Los Angeles, CA 90095, USA.
Nguyen
Tung
T
Lehrer
Robert I
RI
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides; D001419:Bacteria / Q000187:drug effects / Q000378:metabolism*; D001798:Blood Proteins / Q000494:pharmacology; D054804:Cathelicidins; D004305:Dose-Response Relationship, Drug; D004566:Electrodes; D010455:Peptides / Q000494:pharmacology; D011188:Potassium / Q000032:analysis* / Q000378:metabolism; D011506:Proteins / Q000494:pharmacology; D012044:Regression Analysis
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D054804:Cathelicidins; D010455:Peptides; D011506:Proteins; C403305:SMAP29 protein, Ovis aries; C094880:protegrin-1; D011188:Potassium