[Modified water maze for studying spatial memory of rats].
A method for evaluation of impairments of spatial memory in rats is put forward. Sensitivity of the advanced method based on the principles of Morris' water maze was compared with that of the classic prototype. Efficiency of the advanced method was assessed by dose- and time-dependent effects of agroclavine on the spatial memory of rats. Agroclavine (10 micrograms/kg) was shown to produce spatial memory impairment in rats. The obtained results also indicate that the modernized maze is more sensitive in revealing impairments of the spatial memory in rats than the classic water maze.
Lunin
S M
SM
Institute of Cell Biophysics, Russian Academy of Sciences, Puschino.
Nesterov
V V
VV
Nesterova
I V
IV
Bobkova
N V
NV
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004873:Ergolines / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014867:Water
D004873:Ergolines; D014867:Water; C004465:agroclavine