title: [A model of the dynamics of intracellular calcium based on refined kinetics of inhibiting the inositol-1,4,5-trisphoshate-sensitive calcium channel].
abstract: Several new models of intracellular calcium dynamics based on refined inositol-1,4,5-triphosphate-sensitive calcium channel kinetics were studied. The refined kinetic schemes take into account that a cytosolic calcium cannot inhibit inositol-1,4,5-triphosphate receptors when they are bound to inositol-1,4,5-triphosphate. The mathematical analysis of intracellular calcium dynamics based on one of these schemes allowed us to show how different types of Ca response to extracellular stimuli, such as excitability, oscillations, sustained elevation of Ca and frequency encoding can arise with a reasonably good fit to experimental data.
authors.affiliation: Institute of Photobiology, National Academy of Sciences of Belarus, Academicheskaya ul. 27, Minsk, 220072 Belarus.
authors.forename: V G
authors.initials: VG
authors.lastname: Veresov
authors.forename: A G
authors.initials: AG
authors.lastname: Kabak
authors.forename: I D
authors.initials: ID
authors.lastname: Volotovskiĭ
mesh_terms: D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D007700:Kinetics
chemical_list: D015220:Calcium Channels; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium