CJ-15,801, a novel antibiotic from a fungus, Seimatosporium sp.
A novel antibiotic, CJ-15,801 (I), was isolated from the fermentation broth of a fungus, Seimatosporium sp. CL28611. The structure was determined to be a pantothenic acid analog having an alpha,beta-unsaturated carboxylic acid moiety by spectroscopic analyses. The compound inhibits the growth of multi-drug resistant (MDR) Staphylococcus aureus strains with MIC ranging from 6.25 to 50 microg/ml.
Sugie
Y
Y
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. Yutaka.Sugie@japan.pfizer.com
Dekker
K A
KA
Hirai
H
H
Ichiba
T
T
Ishiguro
M
M
Shiomi
Y
Y
Sugiura
A
A
Brennan
L
L
Duignan
J
J
Huang
L H
LH
Sutcliffe
J
J
Kojima
Y
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D010205:Pantothenic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; C449028:CJ-15,801; D010205:Pantothenic Acid