[Nuclease activity of human interleukin-10].
The nuclease activity of human interleukin-10, an immunosuppressive cytokine, was predicted on the basis of structural homology between the 97-105 sequence of human interleukin-10 and the DNA/RNA-hydrolyzing fragment of the endogenous differentiation factor for the HL-60 line of human promyelocyte leukemia cells. The human recombinant interleukin-10 was shown to cleave all forms of plasmid DNA. The role of interleukin-10 in the apoptosis induction in monocytic cells was hypothesized. The English version of the paper.
Dranitsyna
S M
SM
Kostanian
I A
IA
Astapova
M V
MV
Surina
E A
EA
Lipkin
V M
VM
D017209:Apoptosis / Q000502:physiology; D004247:DNA / Q000378:metabolism; D003851:Deoxyribonucleases / Q000378:metabolism; D018922:HL-60 Cells; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism* / Q000494:pharmacology; D008222:Lymphokines / Q000378:metabolism*; D009000:Monocytes / Q000187:drug effects; D010446:Peptide Fragments / Q000378:metabolism* / Q000494:pharmacology; D010957:Plasmids / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D008222:Lymphokines; D010446:Peptide Fragments; C050979:monocyte-macrophage differentiation factor; D016753:Interleukin-10; D004247:DNA; D003851:Deoxyribonucleases