title: Clindamycin resistant strains of Clostridium difficile isolated from cases of C. difficile associated diarrhea (CDAD) in a hospital in Sweden.
abstract: Fifty three strains of C. difficile recovered from the stools of 13 patients with clinical C. difficile associated diarrhea (CDAD) were analyzed for the presence of the ermB gene, for toxigenicity and fingerprinting profile by PCR based assays. Forty five percent of the isolates were resistant to clindamycin and positive for the ermB gene. All clindamycin resistant isolates were ermB positive and belonged to the same fingerprinting group, suggesting clonal spread. These preliminary results suggest that clindamycin resistant isolates may be common etiologic agents of CDAD in Sweden.
authors.affiliation: Department of Infectious Diseases, Orebro Medical Center Hospital, Orebro, Sweden. torbjorn.noren@orebroll.se
authors.forename: Torbjorn
authors.initials: T
authors.lastname: Norén
authors.forename: Yajarayma J
authors.initials: YJ
authors.lastname: Tang-Feldman
authors.forename: Stuart H
authors.initials: SH
authors.lastname: Cohen
authors.forename: Joseph
authors.initials: J
authors.lastname: Silva
authors.forename: Per
authors.initials: P
authors.lastname: Olcén
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D003967:Diarrhea / Q000382:microbiology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008780:Methyltransferases / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase