[Detection of soluble endothelial protein C receptor (sEPCR) in patients with CHD, DM and SLE].
OBJECTIVE
To evaluate the clinical significance of plasma soluble endothelial protein C receptor (sEPCR) level in patients with coronary heart disease (CHD), diabetes mellitus (DM) and systemic lupus erythematosus (SLE).


METHODS
ELISA of antibody-sandwiched principle was used to detect sEPCR in 34 patients with CHD, 42 with DM-II, 63 with SLE and 20 normal controls (NC).


RESULTS
The plasma level of sEPCR in patients with DM was higher than that in NC group (P < 0.05). The sEPCR level in SLE patients with thrombosis and non-thrombosis are higher than that in NC group (P < 0.005 and P < 0.001, respectively). There is no significant difference between the two groups of SLE (P > 0.05), and between the CHD and NC groups.


CONCLUSIONS
sEPCR level increased in DM and SLE, it seems related to the process of inflammatory reaction and damage of endothelial cell.
Wu
J
J
Department of Hematology, Anhui Provincial Hospital, Hefei 230001, China.
Zhou
Z
Z
Ye
S
S
Dai
H
H
Ma
L
L
Xu
X
X
Li
X
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors; D003327:Coronary Disease / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000097:blood*
D001779:Blood Coagulation Factors; D011956:Receptors, Cell Surface; C091963:activated protein C receptor