Teratoid carcinosarcoma of the ovary with prominent neuroectodermal differentiation.
We present what we believe to be only the second report of ovarian teratoid carcinosarcoma. The patient, a 59-year-old woman, was admitted to hospital complaining of a pelvic mass and of abdominal fullness. Advanced ovarian cancer was diagnosed, and a tumorectomy was done. The tumor occupied the pelvis, and metastasis was found in the liver and spleen. The solid tumor was composed of chondrosarcoma, squamous cell carcinoma, adenocarcinoma and malignant neuroectodermal components, which contained ganglioneuroblastoma-like and medulloepithelioma-like areas. Immunohistochemically, the neuroectodermal cells were positive for both neural and epithelial markers. This ovarian tumor consisted of frankly malignant components, with prominent neuroectodermal elements mixed with epithelial and mesenchymal elements in an organoid fashion; a quite rare tumor.
Tanimoto
A
A
Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, Japan.
Arima
N
N
Hayashi
R
R
Hamada
T
T
Matsuki
Y
Y
Sasaguri
Y
Y
D014408:Biomarkers, Tumor / Q000032:analysis; D002296:Carcinosarcoma / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary; D008875:Middle Aged; D017599:Neuroectodermal Tumors / Q000737:chemistry / Q000556:secondary*; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013160:Splenic Neoplasms / Q000556:secondary; D013724:Teratoma / Q000737:chemistry / Q000556:secondary* / Q000601:surgery
D014408:Biomarkers, Tumor