MAP kinases in the immune response.
MAP kinases are among the most ancient signal transduction pathways and are widely used throughout evolution in many physiological processes. In mammalian species, MAP kinases are involved in all aspects of immune responses, from the initiation phase of innate immunity, to activation of adaptive immunity, and to cell death when immune function is complete. In this review, we summarize recent progress in understanding the function and regulation of MAP kinase pathways in these phases of immune responses.
Dong
Chen
C
Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195-7650, USA. chendong@u.washington.edu
Davis
Roger J
RJ
Flavell
Richard A
RA
D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology; D018664:Interleukin-12 / Q000096:biosynthesis; D047908:Intracellular Signaling Peptides and Proteins; D048031:JNK Mitogen-Activated Protein Kinases; D008213:Lymphocyte Activation; D048371:MAP Kinase Kinase 3; D020929:Mitogen-Activated Protein Kinase Kinases / Q000276:immunology; D020928:Mitogen-Activated Protein Kinases / Q000276:immunology*; D011505:Protein-Tyrosine Kinases / Q000276:immunology; D011506:Proteins / Q000276:immunology; D015398:Signal Transduction; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology; D048051:p38 Mitogen-Activated Protein Kinases; D020744:rac GTP-Binding Proteins / Q000276:immunology; D000097642:GADD45 Proteins; D000097766:RAC2 GTP-Binding Protein
D018836:Inflammation Mediators; D018664:Interleukin-12; D047908:Intracellular Signaling Peptides and Proteins; D048031:JNK Mitogen-Activated Protein Kinases; D048371:MAP Kinase Kinase 3; D020929:Mitogen-Activated Protein Kinase Kinases; D020928:Mitogen-Activated Protein Kinases; D011505:Protein-Tyrosine Kinases; D011506:Proteins; D048051:p38 Mitogen-Activated Protein Kinases; D020744:rac GTP-Binding Proteins; D000097642:GADD45 Proteins; D000097766:RAC2 GTP-Binding Protein; C482530:MAP2K3 protein, human