title: Is continuous veno-venous hemofiltration for acetaminophen-induced acute liver and renal failure worthwhile?
abstract: We describe a patient with acute liver and renal failure secondary to acetaminophen and chronic alcohol abuse who was treated aggressively with oral acetylcysteine, continuous renal replacement therapy, glucose and branched-chain amino acid intravenous feeding and ventilatory support. The patient had a predicted mortality of > 95% without liver transplantation however, with intensive ventilatory, renal, and nutritional support he made a complete recovery. We discuss the benefits of aggressive supportive therapy and suggest that continuous renal replacement therapy may allow gentle fluid removal, excellent control of cerebral edema and intravenous feeding that may favorably influence prognosis.
authors.affiliation: Indiana University & Roudebush VA Medical Center, Indianapolis 46202, USA. ragarwal@iupui.edu
authors.forename: R
authors.initials: R
authors.lastname: Agarwal
authors.forename: M O
authors.initials: MO
authors.lastname: Farber
mesh_terms: D000082:Acetaminophen / Q000506:poisoning*; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000628:therapy*; D000328:Adult; D000437:Alcoholism / Q000150:complications; D018712:Analgesics, Non-Narcotic / Q000506:poisoning*; D062787:Drug Overdose; D006440:Hemofiltration; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000628:therapy*; D008297:Male
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen