Cyclin D1 and mammary carcinoma: new insights from transgenic mouse models.
Cyclin D1 is one of the most commonly overexpressed oncogenes in breast cancer, with 45-50% of primary ductal carcinomas overexpressing this oncoprotein. Targeted deletion of the gene encoding cyclin D1 demonstrates an essential role in normal mammary gland development while transgenic studies provide evidence that cyclin D1 is a weak oncogene in mammary epithelium. In a recent exciting development, Yu et al. demonstrate that cyclin D1-deficient mice are resistant to mammary carcinomas induced by c-neu and v-Ha-ras, but not those induced by c-myc or Wnt-1. These findings define a pivotal role for cyclin D1 in a subset of mammary cancers in mice and imply a functional role for cyclin D1 overexpression in human breast cancer.
Sutherland
Robert L
RL
Cancer Research Program, Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, Australia. r.sutherland@garvan.org.au
Musgrove
Elizabeth A
EA
D000818:Animals; D018270:Carcinoma, Ductal, Breast / Q000235:genetics*; D019938:Cyclin D1 / Q000235:genetics*; D004195:Disease Models, Animal; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D015674:Mammary Neoplasms, Animal / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic
D019938:Cyclin D1