Chromosomal imbalances detected by comparative genomic hybridization are associated with outcome of patients with hepatocellular carcinoma.
BACKGROUND
Biologic characteristics of tumors are greatly affected by genetic aberrations. However, to the authors' knowledge there is no study that shows that cytogenetic information is useful for estimating prognosis of patients with hepatocellular carcinoma (HCC).


METHODS
Comparative genomic hybridization (CGH) analysis was performed in 41 HCCs to examine whether the analysis of cytogenetic aberrations allows us to estimate biologic behavior of HCC.


RESULTS
Tumor recurrence was linked to the loss at 13q (P = 0.0027) and to the number of DNA copy number aberrations (DCNAs; P = 0.0003). The decrease in DNA copy number at 8p and 13q and amplification at 11q13 were significantly associated with unfavorable outcome of patients (P = 0.017, P = 0.012, and P = 0.00081, respectively). The number of DCNAs was significantly different between favorable and poor prognosis patients with HCC; 5.78 +/- 2.7 versus 11.13 +/- 4.8 (P = 0.004), and it was an independent prognostic marker in HCCs.


CONCLUSIONS
The current study indicates that cytogenetic information provided by CGH is useful for estimating prognosis of patients with HCC.
Kusano
Noriyoshi
N
Department of Pathology, Yamaguchi University School of Medicine, Ube, Japan. 2byouri@po.cc.yamaguchi-u.ac.jp
Okita
Kiwamu
K
Shirahashi
Hitoshi
H
Harada
Tomohiko
T
Shiraishi
Kei
K
Oga
Atsunori
A
Kawauchi
Shigeto
S
Furuya
Tomoko
T
Sasaki
Kohsuke
K
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D018628:Gene Dosage; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome
D004273:DNA, Neoplasm