Revisiting cell fate specification in the inner ear.
Generating the diversity of cell types in the inner ear may require an interplay between regional compartmentalization and local cellular interactions. Recent evidence has come from gene targeting, lineage analysis, fate mapping and gene expression studies. Notch signaling and neurogenic gene regulation are involved in patterning or specification of sensory organs, ganglion cells and hair cell mechanoreceptors.
Fekete
Donna M
DM
Department of Biological Sciences, Purdue University, 1392 Lilly Hall of Science, West Lafayette, Indiana 47907-1392, USA. dfekete@purdue.edu
Wu
Doris K
DK
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D003056:Cochlear Nerve / Q000166:cytology* / Q000196:embryology*; D007758:Ear, Inner / Q000166:cytology* / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006198:Hair Cells, Auditory / Q000166:cytology / Q000502:physiology*