title: A major decomposition product, citrinin H2, from citrinin on heating with moisture.
abstract: Citrinin is one of the mycotoxins produced by Penicillium citrinum. We examined the decomposition products after heating citrinin in water at 140 degrees C and isolated a major product, citrinin H2 (3-(3,5-dihydroxy-2-methylphenyl)-2-formyloxy-butane). Citrinin H2 did not show significant cytotoxicity to HeLa cells up to a concentration of 200 microg/ml (% cytotoxicity: 39%) in 63 h of incubation, but citrinin showed severe toxicity at a concentration of 25 microg/ml (% cytotoxicity: 73%). HPLC analysis of citrinin after heating under various conditions indicates that citrinin H2 is mainly yielded from citrinin.
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, Kami-ina, Nagano, Japan. hirotam@gipmc.shinshu-u.ac.jp
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Hirota
authors.forename: Alka
authors.initials: A
authors.lastname: Mehta
authors.forename: Keiko
authors.initials: K
authors.lastname: Yoneyama
authors.forename: Naofumi
authors.initials: N
authors.lastname: Kitabatake
authors.forename: B
authors.initials: B
authors.lastname: Menta Alka
mesh_terms: D002953:Citrinin / Q000737:chemistry / Q000494:pharmacology*; D004952:Esters / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006361:Heating; D006801:Humans; D015394:Molecular Structure; D010407:Penicillium; D012118:Resorcinols / Q000737:chemistry / Q000494:pharmacology*; D014867:Water
chemical_list: D004952:Esters; D012118:Resorcinols; C465978:citrinin H2; D014867:Water; D002953:Citrinin