title: Effect of exogenous interleukin-18 (IL-18) and IL-12 in the course of Brucella abortus 2308 infection in mice.
abstract: In this study we demonstrated that combined inoculation of interleukin-12 (IL-12) and IL-18 reduced the number of bacteria in the spleens of mice infected with Brucella abortus 2308 and that the effect of the treatment was mediated by an increased capability of spleen cells to produce gamma interferon at the early phase of infection.
authors.affiliation: Laboratory of Veterinary Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy. pasquali@iss.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Pasquali
authors.forename: Rosanna
authors.initials: R
authors.lastname: Adone
authors.forename: Louis C
authors.initials: LC
authors.lastname: Gasbarre
authors.forename: Claudia
authors.initials: C
authors.lastname: Pistoia
authors.forename: Franco
authors.initials: F
authors.lastname: Ciuchini
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002003:Brucella abortus; D002006:Brucellosis / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D018664:Interleukin-12 / Q000494:pharmacology*; D020382:Interleukin-18 / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D020382:Interleukin-18; D018664:Interleukin-12