Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin.
The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic effect was observed. Conversely, an antagonistic effect was seen in all schedules where etoposide was administered before cisplatin.
Meczes
E L
EL
Paediatric Oncology Laboratory, Cancer Research Unit, Catherine Cookson Building, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH UK.
Pearson
A D J
AD
Austin
C A
CA
Tilby
M J
MJ
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity*; D004357:Drug Synergism; D005047:Etoposide / Q000633:toxicity*; D006801:Humans; D009447:Neuroblastoma; D013997:Time Factors; D014407:Tumor Cells, Cultured
D005047:Etoposide; D002945:Cisplatin