Nickel-catalyzed coupling of aryl iodides with aromatic aldehydes: chemoselective synthesis of ketones.
Aryl iodides (ArI) couple with aryl aldehydes (Ar'CHO) in the presence of Ni(dppe)Br(2) and Zn to give the corresponding biaryl ketones (ArCOAr'). The use of a bidentate phosphine complex is critical to the success of this catalytic reaction. The reaction provides a new procedure for the synthesis of various functionalized biaryl ketones.
Huang
Yi-Chun
YC
Department of Chemistry, Tsing Hua University, Hsinchu, Taiwan 300.
Majumdar
Kanak Kanti
KK
Cheng
Chien-Hong
CH