title: Optimizing wound healing in the face after laser abrasion.
abstract: BACKGROUND
  Laser resurfacing is a popular procedure to improve the physical signs of photoaging. In addition to improvements in treatment modalities, optimizing posttreatment regimens will enhance patient care.
  
  
  OBJECTIVE
  Our purpose was to evaluate the efficacy of two forms of wound care for the face after laser abrasion.
  
  
  METHODS
  Forty-two patients received full-face laser resurfacing at two clinics by using either the UltraPulse carbon dioxide (CO(2)) laser (Coherent Laser Corp, Palo Alto, Calif) alone or followed by an erbium:YAG laser (Derma-20, ESC Sharplan, Inc, Needham, Mass) and/or a blended CO(2)/Er:YAG laser (Derma-K, ESC Sharplan) or a variable pulse erbium:YAG laser (Contour, Sciton Laser Corp, Palo Alto). Twenty-one patients were randomly assigned to a postoperative regimen including Silon-TSR (Bio Med Sciences, Inc, Allentown, Pa) for the first 2 to 3 days after laser resurfacing, followed by Aquaphor ointment (Beiersdorf, Charlotte, NC) to complete the first 2 weeks. The other 21 patients received the resurfacing recovery system (RRS, Neutrogena, Los Angeles, Calif) following a specific regimen. The system includes Fibracol wound dressing (Johnson & Johnson, Skillman, NJ) for 2 days, followed by a hydrogel dressing for 1 to 2 days, followed by an ointment to complete the first 2 weeks. Patients were evaluated for wound healing on days 2, 3, 6-10, 14-16, and 28-30. The skin was swabbed for colonization at every visit to determine the quantity of bacteria throughout the healing process.
  
  
  RESULTS
  Ninety percent of patients in both groups experienced either "no pain" or "minimal pain" during the first 3 days. Total bacterial counts peaked on days 3 and 6 in the patients managed with the RRS and the Silon-TSR/Aquaphor regimen, respectively. The average day at which patients did not require a dressing was 3.0 days in the group managed with the RRS and 3.7 days in the group managed with the Silon-TSR/Aquaphor dressing regimen (P < or =.05). The average day of complete epithelial regeneration was significantly shorter at 6.3 days using the RRS compared with 7.4 days for patients using the Silon-TSR/Aquaphor regimen (P < or =.02). There was no difference in infection, adverse sequelae, exudate management, or pain in either group.
  
  
  CONCLUSIONS
  Healing was optimized in patients using the RRS after laser resurfacing.
authors.affiliation: Dermatology Associates of San Diego County, Inc., 9850 Genesee Ave. Suite 480, La Jolla, CA 92037, USA. mgderm@aol.com
authors.forename: Mitchel P
authors.initials: MP
authors.lastname: Goldman
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Roberts
authors.forename: Greg
authors.initials: G
authors.lastname: Skover
authors.forename: John T
authors.initials: JT
authors.lastname: Lettieri
authors.forename: Richard E
authors.initials: RE
authors.lastname: Fitzpatrick
mesh_terms: D001458:Bandages; D006801:Humans; D053685:Laser Therapy; D009824:Ointments; D011182:Postoperative Care; D011446:Prospective Studies; D012038:Regeneration; D015361:Rhytidoplasty; D016037:Single-Blind Method; D015595:Skin Aging; D014945:Wound Healing; D014946:Wound Infection / Q000209:etiology
chemical_list: D009824:Ointments