title: Coumarins and gamma-pyrone derivatives from Prangos pabularia: antibacterial activity and inhibition of cytokine release.
abstract: The n-hexane and ethyl acetate extracts of the stems and the ethyl acetate extracts of roots from Prangos pabularia afforded an gamma-pyrone derivative and furanocoumarin derivatives with three glucose and gamma-pyrone (pabularin A, B and C), along with 26 previously known compounds (18 coumarins, six terpenoids and two glycosides). Their structures were established on the basis of spectroscopic studies. Of these, 16 coumarin derivatives isolated from P. pabularia were tested for antibacterial activity and inhibition of cytokine release.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Tada
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shikishima
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Shibata
authors.forename: Tomihiko
authors.initials: T
authors.lastname: Higuti
authors.forename: Gisho
authors.initials: G
authors.lastname: Honda
authors.forename: Michiho
authors.initials: M
authors.lastname: Ito
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takeda
authors.forename: Olimjon K
authors.initials: OK
authors.lastname: Kodzhimatov
authors.forename: Ozodbek
authors.initials: O
authors.lastname: Ashurmetov
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Ohmoto
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D002460:Cell Line; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D003374:Coumarins; D016207:Cytokines; D011753:Pyrones