Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups.
Cytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities are also markers of exposure. Our results suggest that the smoking-associated risk for acute myeloid leukaemia is restricted to the t(8;21)(q22;q22) subgroup. This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies.
Moorman
A V
AV
Leukaemia Research Fund Centre for Clinical Epidemiology, University of Leeds, 30 Hyde Terrace, Leeds LS2 9LN, UK. avm@soton.ac.uk
Roman
E
E
Cartwright
R A
RA
Morgan
G J
GJ
D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology* / Q000235:genetics; D012306:Risk; D012907:Smoking / Q000009:adverse effects*; D014178:Translocation, Genetic