[The etiology of steroid hormone insensitivity: nuclear cofactors and subnuclear architecture].
Steroid hormone receptors interact with the basal transcription machinery(BTM) via intermediary cofactor complexes. Two complexes, a CBP/p300 complex with histone acetyltransferase(HAT) and a TRAP/DRIP/ARC/SMCC complex without HAT are identified, and a multistep model is proposed in which the two complexes interact sequentially with nuclear receptors. Recent advances in live-cell imaging techniques have revealed the interrelationship between subnuclear architecture and gene transcription, especially, nuclear receptors are known to form foci in transcriptionally activated state. These advances have developed a novel concept in a disorder of steroid hormone insensitivity. Disruption of the transmission from the AF-1 domain of the androgen receptor to BTM was revealed in a patient with androgen insensitivity who has no mutations in the androgen receptor gene.
Takayanagi
Ryoichi
R
Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University.
D013734:Androgen-Insensitivity Syndrome / Q000503:physiopathology; D006801:Humans; D008297:Male; D011987:Receptors, Steroid / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013256:Steroids / Q000502:physiology*
D011987:Receptors, Steroid; D013256:Steroids