Evidence for an N-glycosylation polymorphism of arylsulfatase a predisposing to alcoholism in Koreans.
This study investigated the possible effect of the pseudodeficient N-glycosylation polymorphism of the arylsulfatase A (ASA) gene on alcohol dependence among Koreans. Alcoholic patients (N=123) were more likely than control subjects to be heterozygous or homozygous for the ASA pseudodeficient N-glycosylation site (36% of alcoholics versus 20% of controls; P<0.01). Among these 123 alcoholic patients, 42 alcoholics were heterozygous and two were homozygous for the ASA pseudodeficient N-glycosylation polymorphism. This result provides evidence that the ASA pseudodeficient N-glycosylation site allele increases the risk of alcohol dependence within a Korean population.
Chung
In-Won
IW
Department of Neuropsychiatry, College of Medicine, Chungbuk National University, Chungbuk, Korea. iwchung@med.chungbuk.ac.kr
Kim
Heon
H
Lee
Sang-Ick
SI
Hong
Joo-Bong
JB
Kim
Yong-Dae
YD
Nan
Hong-Mei
HM
Sribney
William
W
Kim
Yong-Sik
YS
Manowitz
Paul
P
D000437:Alcoholism / Q000201:enzymology / Q000235:genetics*; D001665:Binding Sites / Q000235:genetics; D002553:Cerebroside-Sulfatase / Q000235:genetics* / Q000378:metabolism; D004247:DNA / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006031:Glycosylation; D007723:Korea; D011110:Polymorphism, Genetic
D004247:DNA; D002553:Cerebroside-Sulfatase