Combinatorial chemistry and high-throughput screening in drug discovery: different strategies and formats.
Different strategies for the discovery of novel leads interacting with therapeutically relevant targets are thoroughly presented and discussed, using also three recent examples. Emphasis is given to approaches which do not require extensive resources and budgets, but rather prove how cleverness and creativity can provide active compounds in drug discovery.
Seneci
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Nucleotide Analog Pharma AG, Landsbergerstrasse 50, D-80339 München, Germany. pierfausto.seneci@napag.de
Miertus
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D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods* / Q000639:trends; D008956:Models, Chemical; D019151:Peptide Library
D019151:Peptide Library