Synovial Tissue, Synovial Fluid, and Plasma Distribution of Nonsteroidal Anti-inflammatory Drugs: Clinical Implications.
In the treatment of joint inflammation, the target tissue of nonsteroidal anti-inflammatory (NSAID) drug action is the synovial membrane. Pharmacokinetic behavior of NSAIDs affects their concentration in tissue compartments. Ion trapping of NSAIDs (weak acids) in the more alkaline intracellular environment promotes cellular uptake in inflamed joints. Available data measuring synovial tissue concentrations of three NSAIDs demonstrates higher levels of oxaprozin in comparison to piroxicam and naproxen.
Borenstein
David
D
The George Washington University Medical Center, Washington, DC, USA.