title: Desmopressin for nocturnal enuresis in nephrogenic diabetes insipidus.
abstract: We have investigated two unrelated families, in which two children had inherited primary nocturnal enuresis, and nephrogenic diabetes insipidus caused by new mutations in the aquaporin-2 gene (AQP2). The mutant AQP2 proteins were inactive, suggesting that administration of desmopressin could not concentrate the urine in these patients. However, treatment with desmopressin resolved primary nocturnal enuresis completely. This observation questions the notion that desmopressin resolves primary nocturnal enuresis through pharmacological manipulation of renal concentrating ability only. Desmopressin might also act on extrarenal targets such as the central nervous system.
authors.forename: Dominik
authors.initials: D
authors.lastname: Müller
authors.forename: Nannette
authors.initials: N
authors.lastname: Marr
authors.forename: Tobias
authors.initials: T
authors.lastname: Ankermann
authors.forename: Paul
authors.initials: P
authors.lastname: Eggert
authors.forename: Peter M T
authors.initials: PM
authors.lastname: Deen
mesh_terms: D002648:Child; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D018500:Diabetes Insipidus, Nephrogenic / Q000235:genetics*; D004775:Enuresis / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D010375:Pedigree; D012076:Renal Agents / Q000627:therapeutic use*
chemical_list: D012076:Renal Agents; D003894:Deamino Arginine Vasopressin