Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
Ron
David
D
Skirball Institute of Biomolecular Medicine, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA. ron@saturn.med.nyu.edu
D000818:Animals; D017209:Apoptosis; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics; D003920:Diabetes Mellitus / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008817:Mice, Mutant Strains; D010641:Phenotype; D011384:Proinsulin / Q000737:chemistry / Q000235:genetics; D017510:Protein Folding; D011506:Proteins / Q000235:genetics*; D051742:Transcription Factor CHOP; D014157:Transcription Factors / Q000235:genetics
D022762:CCAAT-Enhancer-Binding Proteins; C497250:Ddit3 protein, mouse; D011506:Proteins; D014157:Transcription Factors; D051742:Transcription Factor CHOP; D011384:Proinsulin