Caenorhabditis elegans unc-37/groucho interacts genetically with components of the transcriptional mediator complex.
Groucho functions as a general corepressor by modulating chromatin structure and has a widespread role in many developmental processes. Here we show that Groucho may also interact with the basal transcriptional machinery. Mutations in Caenorhabditis elegans groucho interact with mutations in components of the transcriptional Mediator complex, resulting in synthetic lethality and loss of male sensory neurons.
Zhang
Hong
H
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Emmons
Scott W
SW
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D029742:Caenorhabditis elegans Proteins; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology; D018398:Homeodomain Proteins; D009154:Mutation / Q000235:genetics / Q000502:physiology; D009687:Nuclear Proteins; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D015398:Signal Transduction / Q000502:physiology; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology; D014158:Transcription, Genetic
D051792:Basic Helix-Loop-Helix Proteins; D029742:Caenorhabditis elegans Proteins; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D015801:Helminth Proteins; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C066502:TUP1 protein, S cerevisiae; C091023:gro protein, Drosophila; C106184:unc-37 protein, C elegans; C068665:pal-1 protein, C elegans