[The effect of three kinds of anti-glaucoma eyedrops on ocular blood flow].
OBJECTIVE
Surveying the changes of ocular blood flow by continuous anti-glaucoma eyedrops for one week.


METHODS
Thirty-two patients in glaucoma clinic were divided into three groups, one treated by 0.5% timolol, one by 0.5% levobunolol and the third by 0.1% dipivefrine, twice a day. Each patient got the retinal and choroidal angiography before and after the medication. We also made the intra- and inter-observer reproducibility test for verifying the credibility of the method used to determine the ocular blood flow. All the data were analyzed by Students't test.


RESULTS
The reproducibility test revealed this method creditable. Timolol and levobunolol could decrease the choroidal blood flow significantly, there was a trend to decrease the optic nerve blood flow after continues application of timolol eyedrops. Dipivefrine did not induce any significant change on ocular blood flow except the mild artery constriction.


CONCLUSIONS
The results suggest that it is necessary to be careful in choosing the anti-glaucoma eyedrops when ischemia plays an important role in glaucomatous damage.
Zhao
J
J
Ophthalmology Department, Peking Union Medical College Hospital, Beijing 100730, China.
Mao
J
J
Sui
R
R
D000328:Adult; D000368:Aged; D004837:Epinephrine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005123:Eye / Q000098:blood supply*; D005260:Female; D005451:Fluorescein Angiography; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D002040:Levobunolol / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D013999:Timolol / Q000494:pharmacology*
D009883:Ophthalmic Solutions; D013999:Timolol; C015173:dipivefrin; D002040:Levobunolol; D004837:Epinephrine