title: Power calculations for a general class of tests of linkage and association that use nuclear families with affected and unaffected sibs.
abstract: Family-based tests of association are now often used when trying to fine-map a disease susceptibility locus. Recently, several tests of linkage and association have been proposed that use nuclear families with multiple affected and unaffected sibs rather than just case-parent triads. In this paper we propose a test that generalizes these previous tests. Formulae are derived to calculate the power of the test for a randomly mating population. These power calculations are used to determine conditions under which it is advantageous to include unaffected sibs in the analysis.
authors.affiliation: Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
authors.forename: N L
authors.initials: NL
authors.lastname: Kaplan
authors.forename: E R
authors.initials: ER
authors.lastname: Martin
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods*; D030342:Genetic Diseases, Inborn / Q000235:genetics; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D009679:Nuclear Family
chemical_list: D005819:Genetic Markers