title: MICA-A5.1 allele is associated with atypical forms of celiac disease in HLA-DQ2-negative patients.
abstract: We selected 38 consecutive celiac disease (CD) patients (from a group of 316 consecutive CD patients) and 91 healthy blood donors, all of whom were HLA-DQ2 (DQA1*0501/DQB1*0201) negative, and investigated the presence of the classically associated alleles HLA-DQ8 and HLA-DRB4. We also studied the distribution of MICA transmembrane alleles in the two clinical forms of the disease. For this reason, these 38 DQ2-negative patients were subdivided into two groups: 18 typical CD patients and 20 atypical CD patients. No differences were found in the distribution of the DRB4 allele between DQ2-negative patients and controls. The HLA-DQ8 heterodimer (DQA1*03xx/DQB1*0302) was increased in CD patients (29%) compared with controls (10%), but no statistical differences were found. No differences were observed in the frequency of these alleles between either group of CD DQ2-negative patients. MICA-A5.1 was increased in atypical CD patients when compared with the typical forms of disease ( P(c)=0.03) and with healthy controls (P(c)=0.002). No other MICA allele was found to be significantly increased in the groups under study. The presence of MICA-A5.1 in atypical CD DQ2-negative patients may indicate a possible role of this allele in the development of CD.
authors.affiliation: Department of Immunology, Hospital Central de Asturias, C/Celestino Villamil, 33.006 Oviedo, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez-Vazquez
authors.forename: Luis
authors.initials: L
authors.lastname: Rodrigo
authors.forename: Dolores
authors.initials: D
authors.lastname: Fuentes
authors.forename: Sabino
authors.initials: S
authors.lastname: Riestra
authors.forename: Carlos
authors.initials: C
authors.lastname: Bousoño
authors.forename: Sonia
authors.initials: S
authors.lastname: Garcia-Fernandez
authors.forename: Jesús
authors.initials: J
authors.lastname: Martinez-Borra
authors.forename: Segundo
authors.initials: S
authors.lastname: Gonzalez
authors.forename: Carlos
authors.initials: C
authors.lastname: Lopez-Larrea
mesh_terms: D000328:Adult; D000483:Alleles; D002446:Celiac Disease / Q000235:genetics* / Q000276:immunology*; D002648:Child; D004064:Digestive System / Q000276:immunology / Q000378:metabolism; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics* / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D006801:Humans
chemical_list: D015235:HLA-B Antigens; D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A