Treatment of renal artery fibromuscular dysplasia with balloon angioplasty: a prospective follow-up study.
OBJECTIVE
to assess restenosis rates and blood pressure response after percutaneous transluminal renal angioplasty (PTRA) in patients treated for fibromuscular dysplastic renal artery stenosis.


METHODS
a prospective 12-month follow-up study of 27 patients with 31 treated renal artery stenosis. Follow-up assessment included colour-coded duplex sonography (CCD) of renal arteries, monitoring of blood pressure, antihypertensive medication, and creatinine measurements before discharge and at 3, 6, and 12 months. Primary end point was defined as a haemodynamically significant restenosis >60% assessed by CCD.


RESULTS
there was a cumulative 23% restenosis rate at 12 months. Arterial hypertension was cured or improved in 93% of patients immediately after the intervention and remained cured/improved in 74% of patients at 12 months of follow-up. Renal failure present in five patients before PTRA stabilised or improved in all patients.


CONCLUSIONS
although restenosis rate after PTRA in fibromuscular dysplasia is as high as in non-ostial atherosclerotic lesions, there remains a considerable higher therapeutic effect. Profound pressure response and recurrent arterial hypertension with restenosis support the high probability of a renovascular origin of arterial hypertension in this young and otherwise healthy population compared to patients with atherosclerotic renal artery lesions.
Birrer
M
M
Swiss Cardiovascular Center, University Hospital, Freiburgstrasse, 3010 Bern, Switzerland.
Do
D D
DD
Mahler
F
F
Triller
J
J
Baumgartner
I
I
D000328:Adult; D000368:Aged; D000800:Angioplasty, Balloon / Q000295:instrumentation; D001794:Blood Pressure / Q000502:physiology; D001807:Blood Vessel Prosthesis; D003404:Creatinine / Q000097:blood; D005260:Female; D005352:Fibromuscular Dysplasia / Q000150:complications* / Q000628:therapy*; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012078:Renal Artery Obstruction / Q000150:complications* / Q000628:therapy*; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency / Q000502:physiology
D003404:Creatinine