title: Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes.
abstract: The relevance of autoimmune hepatitis (AIH) classification for clinical purposes is controversial. We analyzed the outcome after orthotopic liver transplantation (OLT) of nine type I and seven type II AIH patients. Type II patients had a significantly higher incidence of cirrhosis at the time of diagnosis, more resistance to steroid therapy, and a higher Child-Pugh score at the time of OLT. OLT was performed in emergency in three type II patients and electively in all type I patients. Four type II and one type I patients died in the postoperative period. There was no difference regarding the incidence of post-OLT infection and rejection between the two types. No recurrence of AIH was observed. The 6-year actuarial survival rates for type I and type II patients were 76% and 43%, respectively. Type II AIH patients who have a poor response to medical therapy should be considered for OLT with a shortened delay.
authors.affiliation: Service de Chirurgie, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Cattan
authors.forename: Thierry
authors.initials: T
authors.lastname: Berney
authors.forename: Filomena
authors.initials: F
authors.lastname: Conti
authors.forename: Yvon
authors.initials: Y
authors.lastname: Calmus
authors.forename: J C
authors.initials: JC
authors.lastname: Homberg
authors.forename: Didier
authors.initials: D
authors.lastname: Houssin
authors.forename: Olivier
authors.initials: O
authors.lastname: Soubrane
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D019693:Hepatitis, Autoimmune / Q000145:classification* / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation / Q000379:methods* / Q000401:mortality / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000453:epidemiology / Q000401:mortality / Q000601:surgery; D012008:Recurrence; D012086:Reoperation; D016019:Survival Analysis; D016896:Treatment Outcome