[Study on the modulation of the inflammatory response in mouse hepatic vasculitis with sodium selenite and vitamin E antioxidants].
OBJECTIVE
To identify the regulatory effect of sodium selenite and vitamin E on complement-neutrophil-reactive oxygen species (ROS)-activation feedback mechanism-mediated inflammatory response.


METHODS
The modulation of inflammatory response through the complement-neutrophil-ROS-activation feedback cycle with sodium selenite and alpha-tocopherol was verified both in vitro tests by chemiluminescense technique and complement fixation to detect ROS production and complement activation as well as in vivo mouse hepatic vasculitis models to test for the regulation of the inflammatory response.


RESULTS
Convincing results were observed as the incidence of hepatic vasculitis dropped from 100% in the control group down to 20% in the seleno-antioxidant vitamin E treated group, indicating down regulation of the inflammatory response.


CONCLUSIONS
Elucidation of the mechanism of complement mediated inflammatory response is a promising area for new therapeutic developments in the modulation of inflammatory response. This study suggests that selenium, vitamin E and other antioxidants may be the useful therapeutic agents in those disorders in which upregulation of inflammatory response has been implicated, e.g. ischemia, reperfusion injury, severe sepsis, rheumatoid arthritis and hepatitis.
Xu
M
M
Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100005, China.
Hou
J
J
Wu
Y
Y
Ling
Y
Y
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D007249:Inflammation / Q000517:prevention & control; D008107:Liver Diseases / Q000517:prevention & control*; D051379:Mice; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism*; D018038:Sodium Selenite / Q000627:therapeutic use*; D014657:Vasculitis / Q000517:prevention & control*; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D017382:Reactive Oxygen Species; D014810:Vitamin E; D018038:Sodium Selenite