Titin and nebulin content in human skeletal muscle following eccentric resistance exercise.
We measured titin and nebulin content in muscle biopsies from the vastus lateralis before and 24 h after one bout of high-intensity eccentric knee extensor resistance exercise in seven men (26 +/- 3 years). Titin and nebulin content were significantly (P < 0.05) reduced after exercise by 30 and 15%, respectively. These results suggest that the structural components of the myofibrillar apparatus are degraded following high-intensity eccentric resistance exercise in humans. Loss of these proteins may have important implications for the mechanisms regulating the adaptive response of skeletal muscle to resistance exercise.
Trappe
Todd A
TA
Nutrition, Metabolism, and Exercise Laboratory, Donald W. Reynolds Center on Aging, Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 W. Markham, Slot 806, Little Rock, Arkansas 72205, USA. trappetodda@uams.edu
Carrithers
John A
JA
White
Faber
F
Lambert
Charles P
CP
Evans
William J
WJ
Dennis
Richard A
RA
D000328:Adult; D064211:Connectin; D006801:Humans; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D014891:Weight Lifting / Q000502:physiology*
D064211:Connectin; D009124:Muscle Proteins; C577285:TTN protein, human; C035620:nebulin; D011494:Protein Kinases