title: Hydrogenases and hydrogen metabolism of cyanobacteria.
abstract: Cyanobacteria may possess several enzymes that are directly involved in dihydrogen metabolism: nitrogenase(s) catalyzing the production of hydrogen concomitantly with the reduction of dinitrogen to ammonia, an uptake hydrogenase (encoded by hupSL) catalyzing the consumption of hydrogen produced by the nitrogenase, and a bidirectional hydrogenase (encoded by hoxFUYH) which has the capacity to both take up and produce hydrogen. This review summarizes our knowledge about cyanobacterial hydrogenases, focusing on recent progress since the first molecular information was published in 1995. It presents the molecular knowledge about cyanobacterial hupSL and hoxFUYH, their corresponding gene products, and their accessory genes before finishing with an applied aspect--the use of cyanobacteria in a biological, renewable production of the future energy carrier molecular hydrogen. In addition to scientific publications, information from three cyanobacterial genomes, the unicellular Synechocystis strain PCC 6803 and the filamentous heterocystous Anabaena strain PCC 7120 and Nostoc punctiforme (PCC 73102/ATCC 29133) is included.
authors.affiliation: Department of Botany and Institute for Molecular and Cell Biology, University of Porto, 4150-180 Porto, Portugal.
authors.forename: Paula
authors.initials: P
authors.lastname: Tamagnini
authors.forename: Rikard
authors.initials: R
authors.lastname: Axelsson
authors.forename: Pia
authors.initials: P
authors.lastname: Lindberg
authors.forename: Fredrik
authors.initials: F
authors.lastname: Oxelfelt
authors.forename: Röbbe
authors.initials: R
authors.lastname: Wünschiers
authors.forename: Peter
authors.initials: P
authors.lastname: Lindblad
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D000458:Cyanobacteria / Q000201:enzymology* / Q000235:genetics; D006859:Hydrogen / Q000378:metabolism*; D006864:Hydrogenase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data
chemical_list: D006859:Hydrogen; D006864:Hydrogenase