[The relationship between laminin-receptor and nm23 protein expression and its correlation with interstitial microvascular density and tumor metastasis in breast carcinoma].
OBJECTIVE
To study the relationship between 67,000 laminin, laminin-receptor (LN-R) and nm23 protein expression, interstitial microvascular density (MVD) and tumor metastasis in breast carcinomas.


METHODS
The expression of laminin (LN), LN-R, FVIIIRAg and nm23 protein were detected in 73 cases of breast carcinoma with immunohistochemical technique and analyzed.


RESULTS
A significant difference in LN expression was found in breast carcinoma according to their pathological grade. A positive relation exists between LN-R expression and lymph node metastasis. A positive relationship exists between the degree of LN-R and MVD expression. A significant difference in lymph node metastasis cases exists between nm23 protein positive expression group and negative expression group. When the expression of nm23 protein was inhibited, the degree of LN-R, MVD expression increased and positively related with lymph node metastasis.


CONCLUSIONS
LN-R expression enhancement, microvascular density increase and nm23 expression inhibition may be the reliable markers for predicting tumor metastasis and prognosis.
Li
Y
Y
Department of Pathology, Norman Bethune University of Medical Sciences, Changchun 130021, China. liyulin@public.cc.jl.cn
Kou
B
B
Wu
S
S
Zhang
L
L
Zhu
G
G
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000098:blood supply / Q000378:metabolism* / Q000556:secondary; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000098:blood supply / Q000378:metabolism / Q000556:secondary; D018275:Carcinoma, Lobular / Q000098:blood supply / Q000378:metabolism / Q000556:secondary; D005260:Female; D006801:Humans; D007797:Laminin / Q000032:analysis; D008207:Lymphatic Metastasis; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase / Q000032:analysis* / Q000096:biosynthesis; D017474:Receptors, Laminin / Q000032:analysis* / Q000096:biosynthesis
D014408:Biomarkers, Tumor; D007797:Laminin; D054778:NM23 Nucleoside Diphosphate Kinases; D017474:Receptors, Laminin; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase