Synchrotron radiation imaging of internal structures in live animals.
Ionizing radiation has long been used in medicine since the discovery of X-rays. Diagnostic imaging using synchrotron radiation has been under investigation since Rubenstein et al. reported dual-energy iodine-K-edge subtraction coronary angiography. Recently, computed tomography (CT) and magnetic resonance imaging (MRI) have provided better quality results than conventional radiology, providing important information on human internal structures. However, such techniques are unable to detect fine micron sized structures for the early diagnosis of tumors, vascular diseases and other medical objectives. Third generation synchrotron X-rays are well known for their superiority in coherence and energy tunability with respect to conventional X-rays. Consequently, new contrast mechanisms with a superior spatial resolution are becoming available. Here we present the extremely fine details of live animal internal structures using unmonochromatized synchrotron X-rays (white beam) and a simple detector system. Natural movements of the internal organs are also shown. The results indicate that this imaging technique can be applied to investigating microstructures and evaluating the function of the internal organs. Furthermore, this imaging system may be applied to humans as the next tool beyond CT and MRI.
Lee
Kyu Ho
KH
Medical Research Center, Academia Sinica, Taipei, Taiwan. lkh@yumc.yonsei.ac.kr
Hwu
Yeu Kuang
YK
Je
Jung Ho
JH
Tsai
Wen Li
WL
Choi
Eun Wook
EW
Kim
Yong Chul
YC
Kim
Hee Joung
HJ
Seong
Je Kyung
JK
Yi
Seung Won
SW
Ryo
Hyung Sik
HS
Margaritondo
Giorgio
G
D000818:Animals; D003952:Diagnostic Imaging; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D017356:Synchrotrons