Direct interactions between rab GTPases and cargo.
The rab family of small GTPases has numerous roles in intracellular transport including budding, tethering, and fusion of vesicles as well as organelle motility. New data show that cargo proteins are also rab effectors and can therefore regulate their own trafficking by direct interactions with the transport machinery.
Smythe
Elizabeth
E
School of Life Sciences, Division of Cell Biology and Immunology, Wellcome Trust Biocentre, University of Dundee, Dundee, United Kingdom.
D000818:Animals; D016764:Cell Polarity; D004705:Endocytosis; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D046911:Macromolecular Substances; D021381:Protein Transport / Q000502:physiology*; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin / Q000378:metabolism; D019056:Receptors, Polymeric Immunoglobulin / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000502:physiology*; D020692:rab3 GTP-Binding Proteins / Q000502:physiology; D020696:rab5 GTP-Binding Proteins / Q000502:physiology
D007071:Immunoglobulin A, Secretory; D046911:Macromolecular Substances; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin; D019056:Receptors, Polymeric Immunoglobulin; C492131:RAB3B protein, human; D020691:rab GTP-Binding Proteins; D020692:rab3 GTP-Binding Proteins; D020696:rab5 GTP-Binding Proteins