title: Biosynthesis of zeaxanthin via mevalonate in Paracoccus species strain PTA-3335. A product-based retrobiosynthetic study.
abstract: Cultures of the zeaxanthin-producing bacterium Paracoccus species strain PTA-3335 (formerly Flavobacterium) were grown with supplements of (13)C-labeled glucose. Zeaxanthin was isolated and analyzed by (13)C NMR spectroscopy. The data showed that the isoprenoid precursors of zeaxanthin were biosynthesized via the mevalonate pathway. The microorganism was found to utilize glucose mainly via the Entner-Doudoroff pathway.
authors.affiliation: Lehrstuhl für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Federal Republic of Germany. wolfgang.eisenreich@ch.tum.de
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Eisenreich
authors.forename: Adelbert
authors.initials: A
authors.lastname: Bacher
authors.forename: Alan
authors.initials: A
authors.lastname: Berry
authors.forename: Werner
authors.initials: W
authors.lastname: Bretzel
authors.forename: Markus
authors.initials: M
authors.lastname: Hümbelin
authors.forename: Rual
authors.initials: R
authors.lastname: Lopez-Ulibarri
authors.forename: Anne F
authors.initials: AF
authors.lastname: Mayer
authors.forename: Alexei
authors.initials: A
authors.lastname: Yeliseev
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D008798:Mevalonic Acid / Q000378:metabolism*; D015394:Molecular Structure; D010230:Paracoccus / Q000378:metabolism*; D024341:Xanthophylls; D065146:Zeaxanthins; D019207:beta Carotene / Q000031:analogs & derivatives / Q000096:biosynthesis* / Q000737:chemistry
chemical_list: D024341:Xanthophylls; D065146:Zeaxanthins; D019207:beta Carotene; D008798:Mevalonic Acid