Screening for oesophageal neoplasia in patients with head and neck cancer.
Due to advanced disease at the time of diagnosis the prognosis of oesophageal cancer is generally poor. As mass screening for oesophageal cancer is neither feasible nor reasonable, high-risk groups should be identified and surveilled. The aim of this study was to define the risk of oesophageal cancer in patients with (previous) head and neck cancer. A total of 148 patients with (previous) head and neck cancer were prospectively screened for oesophageal cancer by video-oesophagoscopy and random oesophageal biopsies. Even in a macroscopically normal looking oesophagus, four biopsy specimens were taken every 3 cm throughout the entire length of the squamous oesophagus. Low- or high-grade squamous cell dysplasia was detected histologically in 10 of the 148 patients (6.8%). All but one dysplasias were diagnosed synchronously with the head and neck cancers. In addition, oesophageal squamous cell carcinoma was diagnosed in 11 of the 148 patients (7.4%). Most invasive cancers (63.6%) occurred metachronously. The risk of squamous cell neoplasia of the oesophagus is high in patients with (previous) head and neck cancer. Surveillance is recommended in this high-risk group.
Scherübl
H
H
Medical Clinic I, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany. hscher@zedat.fu-berlin.de
von Lampe
B
B
Faiss
S
S
Däubler
P
P
Bohlmann
P
P
Plath
T
T
Foss
H-D
HD
Scherer
H
H
Strunz
A
A
Hoffmeister
B
B
Stein
H
H
Zeitz
M
M
Riecken
E-O
EO
D000368:Aged; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000209:etiology; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications*; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D016609:Neoplasms, Second Primary; D011230:Precancerous Conditions / Q000175:diagnosis*; D011446:Prospective Studies; D018570:Risk Assessment