Detection of human genetic linkage: foundations.
Starting with the basics of inheritance, recombination, and genetic map distance, we develop the theory of linkage analysis considering data on an individual or on a sib pair, with and without data on parents. We discuss the effects of ascertainment of individuals with certain traits and the effects of allelic associations between a trait and a linked marker locus.
Thompson
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Department of Statistics, University of Washington, Seattle, Washington 98195, USA.
D000483:Alleles; D008040:Genetic Linkage; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype; D011995:Recombination, Genetic