Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON).
Antipruritic effects of 70% ethanol extract (CM-ext) of Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri CUSSON, Umberifferae) were investigated. In mice, an oral administration of CM-ext (200 and 500 mg/kg) inhibited compound 48/80-induced scratching behavior without influence on spontaneous locomotion. Isopimpinellin (3) and osthol (1), coumarin derivatives isolated from CM-ext, showed an inhibitory effect on compound 48/80-induced scratching behavior.
Matsuda
Hideaki
H
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Osaka, Japan. kubo@phar.kindai.ac.jp
Ido
Yasuko
Y
Hirata
Atsushi
A
Ino
Yoshiaki
Y
Naruto
Shunsuke
S
Amamiya
Tsutomu
T
Kubo
Michinori
M
D000818:Animals; D000982:Antipruritics / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology; D005638:Fruit; D006636:Histamine Release / Q000187:drug effects; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D000982:Antipruritics; D003374:Coumarins; D010936:Plant Extracts; D003189:p-Methoxy-N-methylphenethylamine