Oxidants painting the cysteine chapel: redox regulation of PTPs.
Growth factors and cytokines appear to stimulate the intracellular production of reactive oxygen species (ROS). Evidence suggests that this alteration in the cellular redox state is essential for downstream signaling, but the precise mechanism has remained elusive. A new study now demonstrates that ligand-stimulated intracellular hydrogen peroxide can specifically and reversibly regulate the activity of protein tyrosine phosphatases.
Xu
Dong
D
Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA.
Rovira
Ilsa I
II
Finkel
Toren
T
D003545:Cysteine / Q000378:metabolism*; D016877:Oxidants / Q000378:metabolism*; D010084:Oxidation-Reduction; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*
D016877:Oxidants; D017027:Protein Tyrosine Phosphatases; D003545:Cysteine