Assessment of the Binax NOW Streptococcus pneumoniae urinary antigen test in children with nasopharyngeal pneumococcal carriage.
We evaluated the Binax NOW Streptococcus pneumoniae urinary antigen assay by testing 210 healthy children aged 2--60 months living in urban slums of Quito, Ecuador. Healthy children with nasopharyngeal carriage of S. pneumoniae were significantly more likely to have positive urinary antigen test results than were children who were not carriers (30 of 138 vs. 3 of 71 children; chi2=10.8; P<.001). The rate of nasopharyngeal carriage of S. pneumoniae decreased with increasing age; the lowest rates were found in children with the worst nutritional status.
Hamer
Davidson H
DH
Division of Geographic Medicine and Infectious Diseases, New England Medical Center, and Center for International Health, Boston University School of Public Health, Boston, MA, USA. dhamer@lifespan.org
Egas
Josefina
J
Estrella
Bertha
B
MacLeod
William B
WB
Griffiths
Jeffrey K
JK
Sempértegui
Fernando
F
D000942:Antigens, Bacterial / Q000652:urine*; D002353:Carrier State / Q000453:epidemiology / Q000382:microbiology; D002675:Child, Preschool; D005189:False Positive Reactions; D006801:Humans; D007223:Infant; D009302:Nasopharyngeal Diseases / Q000382:microbiology; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D013296:Streptococcus pneumoniae / Q000302:isolation & purification*
D000942:Antigens, Bacterial; D011933:Reagent Kits, Diagnostic