title: Exacerbation of Avellino corneal dystrophy after laser in situ keratomileusis.
abstract: OBJECTIVE
  To report a case of Avellino corneal dystrophy that increased in severity 1 year after uncomplicated laser in situ keratomileusis (LASIK) for myopia.
  
  
  METHODS
  Avellino dystrophy was confirmed by polymerase chain reaction sequencing of DNA from the patient and her parents.
  
  
  RESULTS
  Best spectacle-corrected visual acuity decreased from 20/20 to 20/30 12 to 20 months after LASIK owing to opacities that appeared centrally in the corneal stroma and the LASIK flap and remaining posterior stroma interface.
  
  
  CONCLUSIONS
  LASIK is contraindicated in patients with Avellino corneal dystrophy because vision may be reduced by corneal opacities that appear in the interface of the flap and remaining posterior stroma postoperatively.
authors.affiliation: Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Brain Korea 21 Project for Med Science, CPO Box 8044, Seoul 120-752, Korea.
authors.forename: Xiu Hua
authors.initials: XH
authors.lastname: Wan
authors.forename: Hyun Chae
authors.initials: HC
authors.lastname: Lee
authors.forename: R Doyle
authors.initials: RD
authors.lastname: Stulting
authors.forename: Terry
authors.initials: T
authors.lastname: Kim
authors.forename: Seung Eun
authors.initials: SE
authors.lastname: Jung
authors.forename: Moon Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Eung Kweon
authors.initials: EK
authors.lastname: Kim
mesh_terms: D000328:Adult; D000075202:Contraindications; D003317:Corneal Dystrophies, Hereditary / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D003318:Corneal Opacity / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D004252:DNA Mutational Analysis; D018450:Disease Progression; D016326:Extracellular Matrix Proteins; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D009216:Myopia / Q000601:surgery; D009363:Neoplasm Proteins / Q000235:genetics; D016133:Polymerase Chain Reaction; D016212:Transforming Growth Factor beta / Q000235:genetics; D014786:Vision Disorders / Q000209:etiology / Q000503:physiopathology; D014792:Visual Acuity; D000099222:betaIG-H3 Protein
chemical_list: D016326:Extracellular Matrix Proteins; D009363:Neoplasm Proteins; D016212:Transforming Growth Factor beta; D000099222:betaIG-H3 Protein