[The influence of recombinant human growth hormone on the metabolism of glucose and protein in severely burned patients].
OBJECTIVE
To investigate the influence of recombinant human growth hormone (rhGH) on the metabolism of glucose and protein in severely burned patients.


METHODS
The serum levels of total protein and albumin and the incidence of hyperglycemia in 24 cases of severely burned patients treated by rhGH were determined and compared with those in patients without rhGH treatment (control group).


RESULTS
The serum levels of total protein (TP) and albumin in burned patients after being treated by rhGH were much higher than those before treatment and those in control group. The blood level of glucose increased within 2 weeks, especially 1 week postburn. The incidences of hyperglycemia were 52.38%, 50.24% and 20% on 0 similar 3, 4 similar 7 and 8 similar 14 postburn days (PBDs), respectively. And the incidences of hyperglycemia were 100%, 50% and 0% when the administration of rhGH started within 1, 2 and after 2 weeks respectively.


CONCLUSIONS
The systemic protein synthesis in severely burned patients could be accelerated by the use of rhGH. But early administration of rhGH in burned patients could affect blood sugar level obviously. And the optimal time to give rhGH is 2 weeks after burn injury.
Cao
L
L
Institute of Burn Research of Tianjin Municipality, Tianjin 300022 P. R. China.
Deng
S
S
Gao
Z
Z
Xie
Y
Y
Liang
Y
Y
D000328:Adult; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D001798:Blood Proteins / Q000187:drug effects* / Q000378:metabolism; D002056:Burns / Q000097:blood / Q000188:drug therapy*; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012709:Serum Albumin / Q000187:drug effects / Q000378:metabolism; D016896:Treatment Outcome
D001786:Blood Glucose; D001798:Blood Proteins; D012709:Serum Albumin; D013006:Growth Hormone