title: Haptoglobin and malaria.
abstract: Haptoglobin gene knockout mice and wild-type controls were infected with Plasmodium berghei ANKA or Plasmodium chabaudi. The peak parasitaemia and parasite burden were higher in Hp-/- mice than in Hp+/+ mice. The increase in spleen weight following malaria infection was smaller in Hp-/- mice than in Hp+/+ animals. The occurrence of cerebral malaria in P. berghei ANKA infection was not different in Hp gene knockout mice and their controls.
authors.affiliation: Department of Pathology, University of Sydney, New South Wales, Australia. nhunt@med.usyd.edu.au
authors.forename: N H
authors.initials: NH
authors.lastname: Hunt
authors.forename: C
authors.initials: C
authors.lastname: Driussi
authors.forename: L
authors.initials: L
authors.lastname: Sai-Kiang
mesh_terms: D000818:Animals; D005260:Female; D006242:Haptoglobins / Q000378:metabolism* / Q000502:physiology*; D008288:Malaria / Q000378:metabolism* / Q000469:parasitology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D018345:Mice, Knockout; D009929:Organ Size; D010962:Plasmodium berghei / Q000378:metabolism; D012737:Sex Factors; D013154:Spleen / Q000469:parasitology
chemical_list: D006242:Haptoglobins