title: A left ventricle model to predict post-revascularization ejection fraction based on cine magnetic resonance images.
abstract: The left ventricular ejection fraction (LVEF) is an important clinical indicator of the cardiac function and long-term outcome for patients with coronary artery disease. A biomechanical model of the left ventricle was developed to quantitatively predict post-revascularization LVEF based on noninvasive magnetic resonance imaging. The myocardium was categorized into normal, hibernating, and infarcted regions from the ventricular short-axis images. Assuming that hibernating tissue would potentially regain contractility after revascularization, the expected maximum post-revascularization LVEF was calculated for four patients with chronic left ventricular dysfunction. The predictions were within three ejection fraction points of the follow-up LVEFs. This model may be useful to estimate the outcome and efficacy of revascularization plans.
authors.affiliation: School of Mechanical Engineering, Georgia Institute of Technology, Atlanta 30332-0405, USA. haichao.han@me.gatech.edu
authors.forename: Hai-Chao
authors.initials: HC
authors.lastname: Han
authors.forename: John N
authors.initials: JN
authors.lastname: Oshinski
authors.forename: David N
authors.initials: DN
authors.lastname: Ku
authors.forename: Roderic I
authors.initials: RI
authors.lastname: Pettigrew
mesh_terms: D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D019028:Magnetic Resonance Imaging, Cine; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D009204:Myocardial Revascularization / Q000009:adverse effects; D009206:Myocardium / Q000473:pathology; D011237:Predictive Value of Tests; D013318:Stroke Volume / Q000502:physiology; D014022:Tissue Survival; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology / Q000601:surgery