title: [Internal strontium-89 radiotherapy for malignant bony metastasis].
abstract: OBJECTIVE
  This work was done to evaluate the indication, effectiveness, and side effects of internal radiotherapy with radioactive nuclide strontium-89 (89Sr) in patients with malignant metastasis in the bone.
  
  
  METHODS
  Fifty-six patients with skeletal metastasis received this internal radiotherapy. The patients were observed and followed up with respect to pain control, lesion improvement and side effects.
  
  
  RESULTS
  The overall effective rate of pain control was 76.8% with the effective rate of prostatic cancer and breast cancer higher than 80%. The lesions in 81.8% patients as assessed by SPECT imaging, were improved. The mild lowering of white cells, platelets and red cells was the main side effect.
  
  
  CONCLUSIONS
  Internal radiotherapy with 89Sr is very useful for patients with malignant cancer metastasis in the bone.
authors.affiliation: Department of Nuclear Medicine, Sir Run Run Shaw Hospital, Zhejiang University Medical College, Hangzhou 310016, China.
authors.forename: C
authors.initials: C
authors.lastname: Lou
authors.forename: D
authors.initials: D
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary; D001842:Bone and Bones / Q000473:pathology / Q000528:radiation effects; D001943:Breast Neoplasms / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000532:radiotherapy; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D013324:Strontium / Q000009:adverse effects / Q000627:therapeutic use*; D013326:Strontium Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013326:Strontium Radioisotopes; C025700:strontium chloride; D013324:Strontium