Quantitative investigation of acoustic streaming in blood.
Acoustic streaming may have practical utility in diagnostic medical ultrasound in distinguishing between stagnant blood and tissue as well as clotted and unclotted blood. This distinction can be difficult with conventional ultrasound but have high value in managing trauma patients with internal hemorrhage. Ultrasound energy applies a force to blood by momentum transfer, resulting in bulk streaming that is a function of the acoustic attenuation, sound speed, acoustic intensity, blood viscosity, and the boundary conditions posed by the geometry around the hematoma. A simple tubular model was studied analytically, by finite element simulation, and experimentally by in vitro measurement. The simulation agreed closely with measurements while the analytic solutions were found to be valid only for beam diameters approximating the diameter of the tubular channel. Experimentally, the acoustic streaming in blood decreased as the blood began to clot and the streaming flow was not detected in clotted blood. In contrast, the echogenicity of the same blood samples did not change appreciably from the unclotted to the clotted state for the stagnant blood studied. Streaming detection appears to offer a potential tool for improving hemorrhage diagnosis.
Shi
Xuegong
X
Department of Bioengineering, University of Washington, Seattle 98195, USA.
Martin
Roy W
RW
Vaezy
Shahram
S
Crum
Lawrence A
LA
D000162:Acoustics; D001777:Blood Coagulation / Q000502:physiology*; D006470:Hemorrhage / Q000175:diagnosis; D006801:Humans; D008954:Models, Biological