[B7 and DC vaccines induced anti-tumor immunity against murine T-lymphocyte leukemia L615].
OBJECTIVE
To study the effect of B7 and DC vaccines in inducing anti-tumor immunity in murine T-lymphocyte leukemia L615.


METHODS
In vivo, murine mortality and survival were observed to compare the difference between B7 and DC vaccine in inducing immunoprotection against the subsequent challenge of live L615 cells;in vitro, specific cytotoxic assay and MLR were performed to test the specific cytotoxicity and proliferative activity of effective T cells.


RESULTS
Both vaccines could efficiently improve T cell mediated anti-leukemic immunity in syngenic hosts, and DC vaccine was revealed to be more efficient. In vitro observations showed that both vaccines could induce tumor specific cytotoxicity and proliferative activity of effective T cells.


CONCLUSIONS
DC vaccine is promising in tumor immunotherapy owing to its safety, efficiency and convenience.
Li
M
M
State Key Laboratory of Experimental Hematology, Institute of Hematology, CAMS and PUMC, Tianjin 300020, China.
You
S
S
Ma
N
N
Liao
X
X
Wei
D
D
Ge
W
W
Ma
S
S
D000818:Animals; D018122:B7-1 Antigen / Q000276:immunology*; D019496:Cancer Vaccines / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D015458:Leukemia, T-Cell / Q000276:immunology / Q000628:therapy*; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D018122:B7-1 Antigen; D019496:Cancer Vaccines