Localisation of C reactive protein in infarcted tissue sites of multiple organs during sepsis.
This report hypothesises an active role for the acute phase protein, C reactive protein (CRP), in local inflammatory reactions. This was studied in infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy. In this patient, a general acute phase protein reaction was induced, with an increase in plasma CRP. In infarction sites of kidney and liver, colocalisation of CRP and activated complement were found, whereas non-infarct sites were negative for CRP and complement. These results suggest that CRP directly participates in local inflammatory processes, possibly via complement activation, after binding of a suitable ligand.
Baidoshvili
A
A
Department of Pathology, Vrije Universiteit Medical Center ICAR-VU, 1081 HV Amsterdam, The Netherlands.
Nijmeijer
R
R
Lagrand
W K
WK
Hack
C E
CE
Niessen
H W M
HW
D002097:C-Reactive Protein / Q000032:analysis*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007238:Infarction / Q000378:metabolism*; D007668:Kidney / Q000098:blood supply; D008099:Liver / Q000098:blood supply; D008875:Middle Aged; D018805:Sepsis / Q000378:metabolism*
D002097:C-Reactive Protein