title: Design and performance of the UCLH mark 1b 64 channel electrical impedance tomography (EIT) system, optimized for imaging brain function.
abstract: The UCLH Mark 1b is a portable EIT system that can address up to 64 electrodes, which has been designed for imaging brain function with scalp electrodes. It employs a single impedance-measuring circuit and multiplexer so that electrode combinations may be addressed flexibly using software. It operates in the relatively low frequency band between 225 Hz and 77 kHz, as lower frequencies produce larger changes during brain activity, and has a videocassette-sized headbox on a lead 10 m long, connected to a base box the size of a video recorder, and notebook PC, so that recordings may be made in ambulant subjects. Its performance was assessed using a resistor-capacitor network, and two saline-filled tanks-a cylindrical Perspex one and a latex one which contained a human skull. System signal-to-noise ratio was better than 50 dB and the maximum reciprocity error less than 10% for most frequencies. The CMMR was better than 80 dB at 38 kHz and a sponge, 20 mm across, which caused a local 12% impedance increase, was correctly localized in images. This suggests that the system has adequate performance to image impedance changes of 5-50% known to occur in the brain during normal activity, epilepsy or stroke; clinical trials to image these conditions are in progress.
authors.affiliation: Department of Clinical Neurophysiology, Middlesex Hospital, University College London, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Yerworth
authors.forename: R H
authors.initials: RH
authors.lastname: Bayford
authors.forename: G
authors.initials: G
authors.lastname: Cusick
authors.forename: M
authors.initials: M
authors.lastname: Conway
authors.forename: D S
authors.initials: DS
authors.lastname: Holder
mesh_terms: D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D017097:Electric Impedance; D004566:Electrodes; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008953:Models, Anatomic; D015203:Reproducibility of Results; D014054:Tomography / Q000295:instrumentation*