title: [Detection of two polymorphic sites in the human c-fms gene: allele frequency and genotype in some populations of Russia].
abstract: Two polymorphic sites were found in the human c-fms gene: one (G-->A) was in position 34,047 in the last intron, and the other (dinucleotide TC-->CA) was in positions 34,293 and 34,294 in the 3'-untranslated gene region, 34 bp downstream of the translation stop codon. The polymorphic dinucleotide appeared to be immediately upstream of an octamer showing 100% homology to cis element -CAAACTTC-, which is responsible for controlled instability of mRNAs of several genes. Based on these data, functional significance was assumed for this polymorphism of the c-fms gene. Allele frequencies were established for several populations. The mutant allele of the polymorphism located in the intron were detected only in one family of ethnic Germans from the Altaiskii krai. Polymorphism of the second site, which is in the 3'-untranslated region of the c-fms gene, was observed in all Caucasoid and Mongoloid populations examined. Frequency of the rare allele varied from 19.7-25% in Arctic Mongoloids to 31-42.6% in Central Asian Mongoloids and was similar in two Caucasoid populations (22.6% in ethnic Russians and 26.5% in ethnic Germans). The wide distribution of the mutant allele in human populations of the two races was considered indicative of an adaptive role of the polymorphism in providing a certain level of the gene product, a receptor, in certain cell processes.
authors.affiliation: Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090 Russia. romasch@bionet.nsc.ru
authors.forename: A G
authors.initials: AG
authors.lastname: Romashchenko
authors.forename: T N
authors.initials: TN
authors.lastname: Kuznetsova
authors.forename: Ia S
authors.initials: IaS
authors.lastname: Ruzankina
authors.forename: M V
authors.initials: MV
authors.lastname: Kostenko
authors.forename: V F
authors.initials: VF
authors.lastname: Kobzev
authors.forename: I V
authors.initials: IV
authors.lastname: Kulikov
authors.forename: Ch
authors.initials: Ch
authors.lastname: Konchuk
authors.forename: M I
authors.initials: MI
authors.lastname: Voevoda
mesh_terms: D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers; D005838:Genotype; D006801:Humans; D009690:Nucleic Acid Conformation; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000235:genetics*; D012426:Russia
chemical_list: D017931:DNA Primers; D012333:RNA, Messenger; D016186:Receptor, Macrophage Colony-Stimulating Factor