[HIV-1 chemokine receptors and their role in the pathogenesis of AIDS].
Data on cellular receptors playing an important role in penetration of HIV into the cell and determining further development of HIV infection are reviewed. Special attention is paid to chemokine receptors CCR5 and CXCR4. The resistance of some humans to HIV-1 infection, probably due to defective CCR5 gene allele, is discussed.
Nosik
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MN
Matsevich
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GR
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology*; D000483:Alleles; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000276:immunology; D009154:Mutation; D019713:Receptors, CCR5 / Q000235:genetics / Q000502:physiology; D019718:Receptors, CXCR4 / Q000502:physiology; D019707:Receptors, Chemokine / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology
D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D019707:Receptors, Chemokine