Conception and spontaneous delivery after total hypophysectomy.
OBJECTIVE
To report the first case of pregnancy and spontaneous delivery after total hypophysectomy.


METHODS
A case report.


METHODS
University hospital.


METHODS
A 34-year-old woman with panhypopituitarism after hypophysectomy in childhood for craniopharyngioma.


METHODS
Successful fertility treatment followed by sufficient hormone substitution therapy during pregnancy.


METHODS
Clinical variables.


RESULTS
The patient had an uncomplicated spontaneous delivery without any substitution of oxytocin before, during, or after delivery.


CONCLUSIONS
Normal pregnancy and delivery are possible in women with lack of pituitary function. Maternal pituitary oxytocin release seems to play a limited role in the onset and progression of labor.
Volz
Joachim
J
Department of Gynecology and Obstetrics, University Hospital Mannheim, Mannheim, Germany. joachim.volz@gyn.ma.uni-heidelberg.de
Heinrich
Udo
U
Volz-Köster
Stefanie
S
D000328:Adult; D003397:Craniopharyngioma / Q000532:radiotherapy / Q000601:surgery; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D005260:Female; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007016:Hypophysectomy; D008297:Male; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D013974:Thyroxine / Q000627:therapeutic use
D006490:Hemostatics; D003894:Deamino Arginine Vasopressin; D013974:Thyroxine; D006854:Hydrocortisone