NFAT: ubiquitous regulator of cell differentiation and adaptation.
The nuclear factor of activated T cells (NFAT) proteins are a family of transcription factors whose activation is controlled by calcineurin, a Ca(2+)-dependent phosphatase. Originally identified in T cells as inducers of cytokine gene expression, NFAT proteins play varied roles in cells outside of the immune system. This review addresses the recent data implicating NFAT in the control of gene expression influencing the development and adaptation of numerous mammalian cell types.
Horsley
Valerie
V
Department of Pharmacology, Emory University, Atlanta, GA 30322, USA.
Pavlath
Grace K
GK
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D019703:Calcineurin / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D009132:Muscles / Q000378:metabolism; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D004268:DNA-Binding Proteins; D050778:NFATC Transcription Factors; C494003:NFATC1 protein, human; C494006:NFATC2 protein, human; C494008:NFATC3 protein, human; C494010:NFATC4 protein, human; D009687:Nuclear Proteins; D014157:Transcription Factors; D019703:Calcineurin