title: Increased serum thymidine kinase activity in acute sarcoidosis.
abstract: This is the first case report of acute sarcoidosis with increased serum thymidine kinase (TK) activity. A 43-year-old male presented fever, swelling of parotid glands, lymphadenopathy, and peripheral neuropathy. Sarcoidosis was pathologically diagnosed by lung and parotid gland biopsy. His serum TK, which was increased to 11.2 U/l at diagnosis (normal <5 U/l), normalized after glucocorticoid therapy. Serum TK has been considered as a good marker of the proliferative activity of various types of neoplasms. Its rise in sarcoidosis has, however, not been described. Because acute sarcoidosis sometimes resembles malignant lymphoma, the possible rise of serum TK in sarcoidosis may be worthy of note.
authors.affiliation: Second Department of Internal Medicine, Gunma University, Maebashi.
authors.forename: Syunji
authors.initials: S
authors.lastname: Tajima
authors.forename: Yoshichika
authors.initials: Y
authors.lastname: Sando
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Maeno
authors.forename: Naoki
authors.initials: N
authors.lastname: Sagawa
authors.forename: Mami
authors.initials: M
authors.lastname: Nara
authors.forename: Yuri
authors.initials: Y
authors.lastname: Maeno
authors.forename: Junichi
authors.initials: J
authors.lastname: Nakagawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Ito
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hoshino
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Suga
authors.forename: Masashi
authors.initials: M
authors.lastname: Arai
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurabayashi
mesh_terms: D000208:Acute Disease; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015415:Biomarkers; D001706:Biopsy; D003937:Diagnosis, Differential; D015769:Granuloma, Respiratory Tract / Q000209:etiology / Q000473:pathology; D006801:Humans; D008206:Lymphatic Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D008223:Lymphoma / Q000175:diagnosis / Q000201:enzymology; D008297:Male; D010306:Parotid Gland / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography; D012507:Sarcoidosis / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D013937:Thymidine Kinase / Q000097:blood*; D014777:Virus Diseases / Q000175:diagnosis / Q000201:enzymology
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D011239:Prednisolone; D013937:Thymidine Kinase