title: Iridium-catalyzed H/D exchange into organic compounds in water.
abstract: The air-stable complex Cp(PMe(3))IrCl(2) efficiently catalyzes the exchange of deuterium from D(2)O into both activated and unactivated C-H bonds of organic molecules without added acid or stabilizers. Selectivity is observed in many cases, with activation of primary C-H bonds occurring preferentially. A number of new stoichiometric transformations involving the iridiym catalyst precursor are also presented, including an oxidation-decarbonylation reaction with primary alcohols.
authors.affiliation: Department of Chemistry and Center for New Directions in Organic Synthesis (CNDOS), University of California, 94720-1460, USA.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Klei
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Golden
authors.forename: T Don
authors.initials: TD
authors.lastname: Tilley
authors.forename: Robert G
authors.initials: RG
authors.lastname: Bergman