[The rearrangements of immunoglobulin heavy chain and T cell receptor delta genes in patients with acute nonlymphocytic leukemia].
OBJECTIVE
To explore the clinical significance of rearrangements of immunoglobulin heavy chain (IgH) and T cell receptor (TCR) genes in patients with acute nonlymphocytic leukemias.


METHODS
Polymerase chain reaction (PCR) was used to study IgH and TCRdelta genes rearrangements in 30 untreated acute nonlymphocytic leukemia patients.


RESULTS
IgH gene rearrangements were found in 9 patients, and TCRdelta gene rearrangements in 5 patients.


CONCLUSIONS
The lineage infidelity does occur in acute nonlymphocytic leukemia, showing not only a high frequency of IgH gene rearrangement, but also of TCRdelta gene rearrangement.
Wang
Y
Y
The First Affiliated Hospital, Suzhou Medical College, Suzhou 215006, China.
Wang
W
W
Lu
T
T
Pan
J
J
Li
J
J
Wu
D
D
Chen
Z
Z
D015321:Gene Rearrangement; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000276:immunology*; D016133:Polymerase Chain Reaction
D007143:Immunoglobulin Heavy Chains