[Selected blood coagulation problems in newborn infants].
The paper deals with specific features of the neonatal coagulation system. The plasma concentration of the majority of coagulation factors is lower in neonates than in adults, whereby near-adult values are achieved for most components by 6 months of life. Bleeding episodes in haemophilic newborns are rare but may be of a profound nature, thus a proper communication between all involved physicians may aid in the management of such patients. On the other hand thromboembolic episodes might complicate neonatal intensive care, in particular in patients with an indwelling central line. Also inherited thrombophilia might contribute to the development of neonatal thrombosis. Prophylaxis and therapy of vitamin K deficiency bleeding are discussed.
Gallistl
S
S
Ludwig-Boltzmann-Institut für pädiatrische Hämostaseologie, Universitätsklinik für Kinder- und Jugendheilkunde Graz, Auenbruggerplatz 30, A-8036 Graz. siegfried.gallistl@kfunigraz.ac.at
D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology*; D001779:Blood Coagulation Factors / Q000378:metabolism; D005260:Female; D006467:Hemophilia A / Q000097:blood / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening; D011247:Pregnancy; D012307:Risk Factors; D013923:Thromboembolism / Q000097:blood / Q000209:etiology; D014813:Vitamin K Deficiency / Q000097:blood / Q000209:etiology
D001779:Blood Coagulation Factors