HLA-B27-transfected (Salmonella permissive) and HLA-A2-transfected (Salmonella nonpermissive) human monocytic U937 cells differ in their production of cytokines.
The cytokine secretion of the Salmonella-permissive, HLA-B27-positive U937 cells was examined, as it was previously shown that these cells kill Salmonella less efficiently than controls. Salmonella-permissive U937 cells showed upregulated production of interleukin 10 and to a lesser extent tumor necrosis factor alpha. HLA-B27-associated modulation of cytokine responses may have importance in the pathogenesis of reactive arthritis.
Ekman
Päivi
P
National Public Health Institute, Department in Turku, Turku, Finland.
Saarinen
Marja
M
He
Qiushui
Q
Gripenberg-Lerche
Christel
C
Grönberg
Alvar
A
Arvilommi
Heikki
H
Granfors
Kaisa
K
D016918:Arthritis, Reactive / Q000209:etiology*; D016207:Cytokines / Q000378:metabolism*; D015789:HLA-A2 Antigen / Q000096:biosynthesis* / Q000235:genetics; D015796:HLA-B27 Antigen / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D009000:Monocytes / Q000276:immunology* / Q000382:microbiology; D012480:Salmonella Infections / Q000276:immunology*; D020298:U937 Cells
D016207:Cytokines; D015789:HLA-A2 Antigen; D015796:HLA-B27 Antigen