Prognostic value of the stromal cell-derived factor 1 3'A mutation in pediatric human immunodeficiency virus type 1 infection.
A mutation of the stromal cell-derived factor 1 gene (SDF-1 3'A) was shown to protect adults exposed to human immunodeficiency virus type 1 (HIV-1) from infection and to affect HIV disease progression in adults. The presence of this mutation in HIV-1-infected Kenyan children did not predict mother-to-child virus transmission. The SDF-1 3'A polymorphism was studied in 256 HIV-1-infected, 118 HIV-1-exposed but uninfected, and 170 unexposed and uninfected children of Italian origin, and the frequency of SDF-1 3'A heterozygosity and homozygosity in each of the 3 groups was similar. Of the 256 HIV-1-infected children, 194 were regularly followed up and were assigned to groups according to disease progression. The frequency of the SDF-1 3'A allele was substantially lower among children with long-term nonprogression than among children with rapid (P =.0329) or delayed (P =.0375) progression. We show that the presence of the SDF-1 3'A gene correlates with accelerated disease progression in HIV-1-infected children born to seropositive mothers but does not protect against mother-to-child HIV-1 transmission.
Tresoldi
Eleonora
E
HIV Immunobiology Unit, Department of Biotechnology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy. eleonora.tresoldi@hsr.it
Romiti
Maria Luisa
ML
Boniotto
Michele
M
Crovella
Sergio
S
Salvatori
Francesca
F
Palomba
Elvia
E
Pastore
Angela
A
Cancrini
Caterina
C
de Martino
Maurizio
M
Plebani
Anna
A
Castelli
Guido
G
Rossi
Paolo
P
Tovo
Pier Angelo
PA
Amoroso
Antonio
A
Scarlatti
Gabriella
G
D000293:Adolescent; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000503:physiopathology* / Q000821:virology; D015497:HIV-1 / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D009154:Mutation; D011379:Prognosis; D019713:Receptors, CCR5 / Q000235:genetics
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D019713:Receptors, CCR5