title: Safety and Efficacy of Once-Daily Captopril Plus Hydrochlorothiazide versus Nifedipine Gastrointestinal Therapeutic System in Black Patients with Mild to Moderate Hypertension.
abstract: The safety and efficacy of captopril plus hydrochlorothiazide (HCTZ) were compared to nifedipine gastrointestinal therapeutic system (GITS) in 145 randomly assigned black patients with mild to moderate hypertension. Following a 4-week placebo lead-in, patients received captopril plus HCTZ 25/15 mg or nifedipine GITS 30 mg for up to 12 weeks. Upward dose titration was permitted at weeks 3 and 6. Mean seated systolic and diastolic blood pressures decreased 16.1 ± 13.5 mm Hg and 11.5 ± 7.4 mm Hg, respectively, with captopril plus HCTZ. Statistically similar decreases were observed with nifedipine GITS: systolic, 19.3 ± 12.2 mm Hg; diastolic, 13.8 ± 7.2 mm Hg. There were no clinically significant between-group differences in serum chemistries. Edema was reported in 20.3% of nifedipine GITS patients versus 1.4% of captopril plus HCTZ patients (p = 0.001). The two regimens were equally effective in controlling blood pressure in black patients; however, a higher incidence of edema occurred with nifedipine GITS compared to captopril plus HCTZ.
authors.affiliation: University of Maryland School of Medicine, Baltimore, MD.
authors.forename: M. R.
authors.initials: MR
authors.lastname: Weir
authors.forename: D.
authors.initials: D
authors.lastname: Sugimoto
authors.forename: J.
authors.initials: J
authors.lastname: Gray
authors.forename: H.
authors.initials: H
authors.lastname: Black
authors.forename: E.
authors.initials: E
authors.lastname: Saunders
authors.forename: W.
authors.initials: W
authors.lastname: Applegate
authors.forename: J.
authors.initials: J
authors.lastname: Davidson
authors.forename: D.
authors.initials: D
authors.lastname: Ginsberg
authors.forename: T.
authors.initials: T
authors.lastname: Marbury
authors.forename: M.
authors.initials: M
authors.lastname: Moser
authors.forename: D.
authors.initials: D
authors.lastname: Cziner
authors.forename: J.
authors.initials: J
authors.lastname: deSilva
authors.forename: D.
authors.initials: D
authors.lastname: Mills
authors.forename: J.
authors.initials: J
authors.lastname: Rosenblum
authors.forename: W. D.
authors.initials: WD
authors.lastname: Hall