Modified guanidines as chiral auxiliaries.
Investigations on modified guanidines, prepared by newly developed methods, as potential chiral auxiliaries led to reasonable asymmetric induction not only in catalytic but also in stoichiometric asymmetric syntheses. These guanidine-mediated reactions may contribute to the development of green chemistry because of their possible application as re-cyclable (economically favored) and easily functionalizable (widely applicable) auxiliaries.
Ishikawa
Tsutomu
T
Department of Medicinal Organic Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Inage, Japan. benti@p.chiba-u.ac.jp
Isobe
Toshio
T