title: Amphidinolide W, a new 12-membered macrolide from dinoflagellate Amphidinium sp.
abstract: A new cytotoxic 12-membered macrolide, amphidinolide W (1), has been isolated from a marine dinoflagellate Amphidinium sp., and the structure was elucidated by spectroscopic data including (13)C-(13)C INADEQUATE correlations for its (13)C-enriched sample. The absolute stereochemistry of 1 was assigned by combination of J-based configuration analysis and modified Mosher method. Amphidinolide W (1) is the first macrolide without an exomethylene unit among all amphidinolides obtained so far.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Shimbo
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsuda
authors.forename: Naoko
authors.initials: N
authors.lastname: Izui
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D000097442:Amphidinolides
chemical_list: D018942:Macrolides; C449925:amphidinolide W; D000097442:Amphidinolides