Solid phase synthesis of structurally diverse tetra substituted pyrimidines for potential use in combinatorial chemistry.
A new pyrimidine based scaffold has been identified for generation of combinatorial libraries using solid phase technique. The utility of the scaffolds was demonstrated by synthesizing small libraries of 12 substituted pyrimidines (4a-4l).
Chauhan
P M S
PM
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226001, U.P., Lucknow, India. Premsc58@hotmail.com
Kumar
Arun
A
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis*; D013890:Thiourea / Q000737:chemistry
D011743:Pyrimidines; D013890:Thiourea