Ellagitannins from Lagerstroemia speciosa as activators of glucose transport in fat cells.
Glucose transport enhancers were searched for in Lagerstroemia speciosa, a Philippine local herbal medicine used for diabetes mellitus. Bioassay-guided fractionation of the aqueous acetone extract of the leaves afforded three active ellagitannins, lagerstroemin, flosin B and reginin A, identified by NMR and optical rotation. These compounds increased glucose uptake of rat adipocytes, and could be responsible for lowering the blood glucose level.
Hayashi
Takeo
T
Maruyama
Haruko
H
Kasai
Royji
R
Hattori
Katsuji
K
Takasuga
Shunsuke
S
Hazeki
Osamu
O
Yamasaki
Kazuo
K
Tanaka
Takashi
T
D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D003847:Deoxyglucose / Q000378:metabolism; D047348:Hydrolyzable Tannins; D029561:Lythraceae; D009004:Monosaccharide Transport Proteins / Q000187:drug effects*; D010679:Philippines; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D013634:Tannins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D047348:Hydrolyzable Tannins; D009004:Monosaccharide Transport Proteins; D010936:Plant Extracts; D013634:Tannins; C013515:ellagitannin; C455119:flosin B; C455118:lagerstroemin; C455120:reginin A; D003847:Deoxyglucose