Epigenetic reprogramming in the mammalian embryo: struggle of the clones.
During preimplantation development in mammals, distinct epigenetic marks on oocyte and sperm DNA are remodeled to an embryonic pattern. A recent study examining global methylation of repetitive elements in various mammals showed that the reprogramming that occurs during normal preimplantation development is aberrant in cloned embryos.
Mann
Mellissa R W
MR
Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. bartolom@mail.med.upenn.edu
Bartolomei
Marisa S
MS
D000818:Animals; D019976:Cloning, Organism; D019175:DNA Methylation; D004622:Embryo, Mammalian / Q000737:chemistry* / Q000378:metabolism*; D004625:Embryo, Nonmammalian; D047108:Embryonic Development / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D018392:Genomic Imprinting / Q000235:genetics*; D020071:Interspersed Repetitive Sequences / Q000235:genetics; D011247:Pregnancy
D005819:Genetic Markers