[Effect of ryodipine, fenigidin, verapamil, and manganese ions on the contractile strength and the myometrium potential duration during rhythmic stimulation and at rest].
Action of the calcium channels blocking agents was studied using their strong but reversible concentrations, in different regimens. Riodypine and phenihydine suppressed the contraction strength and shortened the AP duration in the myometrium muscle stripes equally effectively both in resting and under stimulation (0.3 Hz). Verapamyl and manganese ions suppressed the contraction strength and shortened the AP duration more effectively under rhythmic stimulation than in resting.
D'iachuk
G I
GI
I. I. Machnikov St. Petersburg State Medical Academy, 195067, St. Petersburg, 47 Piskarevsky Pr., Russia.
Arushanian
N G
NG
Abramchenko
V V
VV
D000200:Action Potentials; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004558:Electric Stimulation; D005260:Female; D066298:In Vitro Techniques; D007477:Ions; D007537:Isometric Contraction / Q000187:drug effects; D008345:Manganese / Q000494:pharmacology; D051379:Mice; D009215:Myometrium / Q000187:drug effects* / Q000502:physiology; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010507:Periodicity; D014590:Uterine Contraction / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D007477:Ions; D008345:Manganese; D014700:Verapamil; D009543:Nifedipine; C045912:ryodipine