title: Inhibition of bacterial growth, enterotoxin production, and spore outgrowth in strains of Bacillus cereus by bacteriocin AS-48.
abstract: Bacteriocin AS-48 showed high bactericidal activity for mesophilic and psychrotrophic strains of Bacillus cereus over a broad pH range. AS-48 inhibition of the enterotoxin-producing strain LWL1 was enhanced by sodium nitrite, sodium lactate, and sodium chloride. The latter also enhanced AS-48 activity against strain CECT 131. Bacterial growth and enterotoxin production by strain LWL1 were completely inhibited at bacteriocin concentrations of 7.5 microg/ml. At subinhibitory bacteriocin concentrations, enterotoxin production decreased markedly and sporulation was delayed. Intact spores were resistant to AS-48 but became gradually sensitive to AS-48 during the course of germination.
authors.affiliation: Departamento de Microbiología, Facultad de Ciencias, Universidad de Granada, C/Fuentenueva s/n, 18071 Grenada, Spain.
authors.forename: Hikmate
authors.initials: H
authors.lastname: Abriouel
authors.forename: Mercedes
authors.initials: M
authors.lastname: Maqueda
authors.forename: Antonio
authors.initials: A
authors.lastname: Gálvez
authors.forename: Manuel
authors.initials: M
authors.lastname: Martínez-Bueno
authors.forename: Eva
authors.initials: E
authors.lastname: Valdivia
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001409:Bacillus cereus / Q000187:drug effects* / Q000254:growth & development* / Q000378:metabolism; D001426:Bacterial Proteins; D003470:Culture Media; D004768:Enterotoxins / Q000096:biosynthesis*; D010455:Peptides; D013171:Spores, Bacterial / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003470:Culture Media; D004768:Enterotoxins; D010455:Peptides; C051034:BacA protein, Enterococcus faecalis