[The effects of extensive excision of massive invasive infected burn wound on the REE of burn patients with sepsis].
OBJECTIVE
To explore the effects of extensive excision of massive invasive infected burn wound on the REE of burn patients with sepsis.


METHODS
REEs and plasma levels of IL -- 6, IL -- 8, TNFalpha and LPS were determined before and after surgical interventions and when patients', condition improved in 8 burned cases with sepsis.


RESULTS
All the 8 patients survived after treatment. The REE level in patients after operation was significantly lower than those before the operation (P < 0.01). REE in patients whose condition improved decreased obviously when compared to that after operation (P < 0.01). The plasma levels of IL -- 6, IL -- 8, TNFalpha and LPS decreased markedly after the operation when compared to those before operation (P < 0.05). and there were lower levels of these factors when the patients', condition improved (P < 0.001). Furthermore, there were closely positive correlations between REE and plasma IL -- 6, IL -- 8, TNFalpha and LPS (P < 0.01).


CONCLUSIONS
Over -- releasing of some inflammatory mediators could be corrected by means of extensive excision of massive invasively infected burn wound. This might be beneficial to the control or the amelioration of the hypermetabolism in burn patients with sepsis.
Chai
J
J
Department of Burns, The 304th Hospital of PLA, Beijing 100037, P.R. China.
Sheng
Z
Z
Gao
J
J
D000293:Adolescent; D000328:Adult; D001481:Basal Metabolism; D002056:Burns / Q000378:metabolism* / Q000382:microbiology / Q000601:surgery; D002648:Child; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008070:Lipopolysaccharides / Q000097:blood; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000097:blood*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015850:Interleukin-6; D016209:Interleukin-8; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha