Lipid peroxidation in malignant tumors of human kidneys.
The intensity of ascorbate-dependent free radical oxidation of endogenous lipids in malignant tumor tissue of human kidneys was studied. The LPO induction period was markedly increased in renal-cell carcinoma and malignant mesenchymal tumors compared to normal renal cortex. The content of alpha-tocopherol in cancer tissue lipids was considerably (7-fold) increased compared to that in normal renal cortex, which explains high antioxidant activity of these carcinomas. A less pronounced increase in the content of alpha -tocopherol in lipids of malignant mesenchymal tumors compared to the cortex (2-fold) can also contribute to their LPO resistance.
Nikiforova
N V
NV
Institute of Urology, Ministry of Health of Russian Federation, Moscow.
Khodyreva
L A
LA
Kirpatovskii
V I
VI
Chumakov
A M
AM
D000328:Adult; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005260:Female; D005609:Free Radicals; D006801:Humans; D007672:Kidney Cortex / Q000378:metabolism; D007680:Kidney Neoplasms / Q000378:metabolism*; D007700:Kinetics; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008297:Male; D008648:Mesoderm / Q000378:metabolism; D008875:Middle Aged; D013997:Time Factors; D024502:alpha-Tocopherol / Q000378:metabolism
D000975:Antioxidants; D005231:Fatty Acids, Unsaturated; D005609:Free Radicals; D024502:alpha-Tocopherol; D001205:Ascorbic Acid