title: Pityriasis lichenoides in a girl with the granulomatous form of common variable immunodeficiency.
abstract: Pityriasis lichenoides (PL) is a cutaneous disease of unknown origin. In our 8-year-old female patient with the granulomatous form of common variable immunodeficiency (CVID), PL occurred together with massive splenomegaly and intra-abdominal lymphadenopathy. Prednisone was efficient for treatment of her splenomegaly and autoimmune cytopenias. However, PL was resistant to both topical and systemic steroid treatment. Healing of PL was achieved with the use of a super-potent topical steroid, clobetasol propionate. A defect of T-cell function in CVID may contribute to development of PL. In the granulomatous form of CVID, sarcoid-like granulomas are the most commonly reported cutaneous lesions. PL has not been previously reported.
authors.affiliation: Pediatric Immunology, Mother and Child Health Institute, Belgrade, Yugoslavia.
authors.forename: Srdjan
authors.initials: S
authors.lastname: Pasic
authors.forename: Milos
authors.initials: M
authors.lastname: Pavlovic
authors.forename: Danilo
authors.initials: D
authors.lastname: Vojvodic
authors.forename: Mario
authors.initials: M
authors.lastname: Abinun
mesh_terms: D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D002990:Clobetasol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000473:pathology; D005260:Female; D005938:Glucocorticoids; D006099:Granuloma / Q000150:complications* / Q000473:pathology; D006801:Humans; D017514:Pityriasis Lichenoides / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D012871:Skin Diseases / Q000150:complications / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D002990:Clobetasol