[The significance and characteristics of the gene expressions of c-fos and c-jun in hypertrophic scar and chronic ulcer tissues].
OBJECTIVE
To explore the characteristics and regularity of the expression of c-fos and c-jun genes in hypertrophic scar and chronic ulcer tissues and their relationship to different tissue restoration.


METHODS
Tissue samples of hypertrophic scars were harvested from 16 cases of patients after burns and chronic cutaneous ulcers during operation together with the normal skin (n = 5) of the same patients as control. ABC method was employed to detect the gene expression of both c- fos and c-jun in above samples.


RESULTS
The positive expression of c-fos and c-jun gene was found in epithelial basal cells and some subcutaneous fibroblasts in normal skin. But the expression of c-jun was weaker than that of c-fos in above tissues. A strong positive expression of c-fos and c-jun genes was found mainly in fibroblasts in the hypertrophic scar. But the combined expression of both tumor genes was most often found in the capillary endothelium, some inflammatory cells and the cytoplasm of fibroblasts in ulcer tissue.


CONCLUSIONS
The results indicated that the amount and location of the expression of c-fos and c-jun genes were different in the three kinds of tissues, suggesting that these two tumor genes may play important roles in wound healing modulation.
Fu
X
X
Burn Institute. 304th Hospital, PLA, Beijing, 100037, P.R. China.
Jiang
L
L
Sun
T
T
D000328:Adult; D017439:Cicatrix, Hypertrophic / Q000378:metabolism*; D005260:Female; D016762:Genes, fos; D016758:Genes, jun; D006801:Humans; D008297:Male; D014456:Ulcer / Q000378:metabolism*; D014945:Wound Healing