title: Effects of intense pulsed light on sun-damaged human skin, routine, and ultrastructural analysis.
abstract: OBJECTIVE
  New, non-ablative methods can be used in skin rejuvenation. Histologic analysis of non-ablative IPL effects on facial, sun-damaged skin.
  
  
  METHODS
  Five female subjects, wrinkle class I or II and Fitzpatrick skin types I, II, and III. IPL treatment: once monthly, 560-nm cut-off filters, spot size 8x35 mm, 28-36 J/cm. Routine histology or electron microscopy on 2-mm punches, before treatment and then 1 week, 3 months, and 12 months.
  
  
  RESULTS
  Pre-treatment specimens contained solar elastosis and perifollicular lymphoid infiltrates. Collagen and elastic fibers appeared unaffected by treatment. At 1-week, Demodex organisms appeared coagulated.
  
  
  CONCLUSIONS
  Under these conditions, IPL induces minimal morphologic changes in mildly sun-damaged skin. Some esthetic improvement may be secondary to clearing of Demodex organisms and reduction of associated lymphocytic infiltrate.
authors.affiliation: Department of Pathology, UT-MD Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: Victor G
authors.initials: VG
authors.lastname: Prieto
authors.forename: Neil S
authors.initials: NS
authors.lastname: Sadick
authors.forename: Josep
authors.initials: J
authors.lastname: Lloreta
authors.forename: Judy
authors.initials: J
authors.lastname: Nicholson
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Shea
mesh_terms: D003094:Collagen / Q000032:analysis; D005145:Face; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D010789:Phototherapy / Q000379:methods*; D012060:Rejuvenation; D012867:Skin / Q000737:chemistry / Q000648:ultrastructure*; D015595:Skin Aging / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D003094:Collagen