title: Analysis of genetic aberrations in uterine adenomyosis using comparative genomic hybridization.
abstract: OBJECTIVE
  To use comparative genomic hybridization (CGH) to analyzefrozen tissuesfrom adenomyosis cases to discover and map genomic regions for chromosomal gains and losses.
  
  
  METHODS
  In a retrospective study, upper and lower threshold values of 1.20 and 0.80, respectively, were used to define positive findings.
  
  
  RESULTS
  No positive recurrent gene copy number alterations were detected in the 25 cases of pathologically proven adenomyosis.
  
  
  CONCLUSIONS
  Although CGH is extremely useful in investigating candidate genes in the development of adenomyosis, CGH was not useful in this study. Genetic changes might be indeed extremely rare in adenomyosis, or CGH was not sensitive enough to detect candidate genes.
authors.affiliation: Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taiwan. phwang@vghtpe.gov.tw
authors.forename: Peng-Hui
authors.initials: PH
authors.lastname: Wang
authors.forename: Wen-Yuann
authors.initials: WY
authors.lastname: Shyong
authors.forename: Chi-Hung
authors.initials: CH
authors.lastname: Lin
authors.forename: Yann-Jang
authors.initials: YJ
authors.lastname: Chen
authors.forename: Ywan Feng
authors.initials: YF
authors.lastname: Li
authors.forename: Hsiang-Tai
authors.initials: HT
authors.lastname: Chao
authors.forename: Chiou-Chung
authors.initials: CC
authors.lastname: Yuan
mesh_terms: D002869:Chromosome Aberrations; D004247:DNA / Q000032:analysis*; D004715:Endometriosis / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D005260:Female; D018628:Gene Dosage; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007621:Karyotyping; D009693:Nucleic Acid Hybridization; D012189:Retrospective Studies; D014591:Uterine Diseases / Q000235:genetics* / Q000473:pathology / Q000601:surgery
chemical_list: D004247:DNA