title: Invasive group A Streptococcal infections at Chulalongkorn University Hospital.
abstract: To determine whether the incidence and pattern of group A Streptococcal (GAS) infections in Thailand have paralleled those in the United States and Europe, we conducted a retrospective study of invasive GAS infections at Chulalongkorn University Hospital from 1995 to 1999. A total of 42 cases were identified. There were 18 males and 24 females (median age of 59 and 46 years, respectively). Most patients were in two age groups: 20-39 (33%) and 60-79 (38%). Underlying conditions were present in 34 patients (81%), including mostly chronic system diseases (50%), alcohol abuse (19%), diabetes mellitus (14%), connective tissue diseases (12%), immunosuppressive illnesses (12%), and human immunodeficiency virus infection (10%). The most common clinical presentations were skin and soft-tissue infections (31%), primary bacteremia (29%), and arthritis (14%). Of these, 24 (57%) presented with toxic shock syndrome (TSS). Overall mortality rate was 33 per cent. All GAS but one isolate were susceptible to penicillin.
authors.affiliation: Department of Medicine, Faculty of Medicine, Chulalongkom University, Bangkok, Thailand.
authors.forename: C
authors.initials: C
authors.lastname: Suankratay
authors.forename: P
authors.initials: P
authors.lastname: Nunthapisud
authors.forename: H
authors.initials: H
authors.lastname: Wilde
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000382:microbiology; D002648:Child; D003646:Debridement; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012772:Shock, Septic / Q000382:microbiology; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000601:surgery; D013297:Streptococcus pyogenes; D013785:Thailand / Q000453:epidemiology