No association found between the Ala54Thr polymorphism of FABP2 gene and obesity and obesity with dyslipidemia in Japanese schoolchildren.
To investigate whether the Ala54Thr polymorphism of the fatty acid binding protein 2 gene is associated with obesity and obesity with dyslipidemia in Japanese schoolchildren, we analyzed 370 children with morbid obesity and 463 control children of normal weight. The allele frequencies did not differ significantly between the control group and the morbidly obese group. The odds ratio (95% confidence interval CI) in obesity of the The54 allele was 1.0 (0.9-1.3). There were no significant differences in obesity index and metabolic characteristics between the two groups. The odds ratio (95% CI) in dyslipidemia of the Thr54 allele was 1.1 (0.8-1.4) in the morbidly obese group. Our data suggested that Ala54Thr polymorphism of the FABP2 gene is not a major contributing factor for obesity and obesity with dyslipidemia in Japanese children.
Endo
K
K
Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan.
Yanagi
H
H
Hirano
C
C
Hayakawa
Y
Y
Hamaguchi
H
H
Tomura
S
S
D000293:Adolescent; D000409:Alanine / Q000235:genetics*; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002648:Child; D017931:DNA Primers; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D007564:Japan; D008297:Male; D009363:Neoplasm Proteins; D009765:Obesity / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D013912:Threonine / Q000235:genetics*; D025521:Tumor Suppressor Proteins
D002352:Carrier Proteins; D017931:DNA Primers; C493404:FABP2 protein, human; C107608:FABP7 protein, human; C493405:Fabp2 protein, mouse; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; D013912:Threonine; D000409:Alanine