[Substance P as a factor enhancing resistance of the surfactant lung system to chronic immobilization stress].
In chronic experiments on non-line white rats the influence of system (intraperitoneal) and central (into the lateral brain ventricle) administration of substance P on lung surfactant system was studied in stressed and non-stressed animals. A single injection of substance P limited pulmonary surfactant activity disorders in immobilisation stress. Stress-induced increase of phospholipids level in broncho-alveolar lavage fluid remained the same in intracerebroventricular administration and was partly reduced in intraperitoneal one. In intact rats, a single injection of peptide was accompanied by alveolar phospholipids accumulation. In rabbits, multiple intracerebroventricular injections of substance P enhanced the opposite effect.
Bryndina
I G
IG
Izhevsk State Medical Academy, 426034, Izhevsk, 199 Revolutsionnaya St., Russia.
Danilov
G E
GE
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D007103:Immobilization; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D010743:Phospholipids / Q000032:analysis; D011663:Pulmonary Surfactants / Q000737:chemistry / Q000502:physiology*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013315:Stress, Psychological / Q000378:metabolism / Q000517:prevention & control*; D013373:Substance P / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*
D010743:Phospholipids; D011663:Pulmonary Surfactants; D013373:Substance P