Impact of combinations of antineoplastic drugs on intestinal microflora in 9 patients with leukaemia.
The impact of antineoplastic drugs on the intestinal microflora was studied in 9 patients with acute leukaemia during chemotherapy and in 5 patients also during chemotherapy-induced neutropenia. Quantitative and qualitative microbiological analyses of faecal samples obtained before and during chemotherapy showed significantly increased counts of Bacteroides spp. in 3/9 patients and, during neutropenia, significantly increased counts of yeasts in 2/5 patients; however, the intestinal microflora was stable in most patients.
Nyhlén
Anna
A
Department of Infectious Diseases, University Hospital of Lund, Sweden.
Ljungberg
Bengt
B
Nilsson-Ehle
Ingrid
I
Nord
Carl Erik
CE
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D001439:Bacteroides / Q000187:drug effects; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D007422:Intestines / Q000187:drug effects / Q000382:microbiology*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D015003:Yeasts / Q000187:drug effects