NKT cells - conductors of tumor immunity?
NKT cells are key players in the regulation of antitumor immunity, particularly in experimental models of tumor immunotherapy, such as IL-12 or alpha-galactosylceramide administration. They may also operate in natural antitumor immunity. NKT cells are best known for their immunosuppressive functions; however, NKT cells interact with a range of other cell types (particularly dendritic cells and NK cells) and the outcome of NKT-cell stimulation depends on these and on the cytokine/co-stimulatory milieu.
Smyth
Mark J
MJ
Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia. m.smyth@pmci.unimelb.edu.au
Crowe
Nadine Y
NY
Hayakawa
Yoshihiro
Y
Takeda
Kazuyoshi
K
Yagita
Hideo
H
Godfrey
Dale I
DI
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology; D005699:Galactosylceramides / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D007371:Interferon-gamma / Q000276:immunology; D018664:Interleukin-12 / Q000276:immunology / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D009374:Neoplasms, Experimental / Q000276:immunology / Q000628:therapy
D000276:Adjuvants, Immunologic; D005699:Galactosylceramides; D018664:Interleukin-12; D007371:Interferon-gamma