title: Complications of central venous catheters in patients with haemophilia and inhibitors.
abstract: We report our clinical experience with central venous catheters (CVCs) in 15 patients with haemophilia who, in total, had 34 catheters inserted. Eighteen devices were Hickman, six were Port-A-Cath and 10 were nontunnelled catheters (one Quinton, seven antecubital, one jugular and one subclavian vein access). All patients had factor VIII/IX inhibitors at the time of insertion. The mean age at operation was 8.8 years (range 16 months-39 years). Eight of the 15 patients (26/34 implanted catheters, 76%) presented some kind of complication. Pericatheter bleeding during the postoperative period affected a total of seven CVCs (7/34, 20%) in six patients, which required substitutive treatment for several days. Infection was reported in 15 of the CVCs (15/34, 44%), and four of these (4/15, 26%) had more than one episode, with a mean of 1.4 infection episodes per catheter (21/15). The infection rate was 0.2 infections per 1000 patient days or 0.1 per 1000 catheter days. Despite the usefulness of CVCs in haemophilic patients, the high incidence of complications requires careful assessment of the type of device as well as continuous surveillance.
authors.affiliation: Haemophilia Centre, Servicio de Hematología y Hemoterapia, Hospital Universitario La Paz, Madrid, Spain. martamorado@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Morado
authors.forename: V
authors.initials: V
authors.lastname: Jimenez-Yuste
authors.forename: A
authors.initials: A
authors.lastname: Villar
authors.forename: M
authors.initials: M
authors.lastname: Quintana
authors.forename: F
authors.initials: F
authors.lastname: Del Castillo
authors.forename: G
authors.initials: G
authors.lastname: Garzon
authors.forename: I
authors.initials: I
authors.lastname: Acitores
authors.forename: F
authors.initials: F
authors.lastname: Ibañez
authors.forename: M J
authors.initials: MJ
authors.lastname: Sanjurjo
authors.forename: J
authors.initials: J
authors.lastname: Gago
authors.forename: F
authors.initials: F
authors.lastname: Hernandez-Navarro
mesh_terms: D000293:Adolescent; D000328:Adult; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation / Q000706:statistics & numerical data; D002648:Child; D002675:Child, Preschool; D005164:Factor IX / Q000276:immunology; D005169:Factor VIII / Q000276:immunology; D006467:Hemophilia A / Q000150:complications* / Q000276:immunology / Q000601:surgery; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007223:Infant; D007239:Infections / Q000209:etiology / Q000382:microbiology / Q000635:transmission; D007518:Isoantibodies / Q000097:blood*; D011183:Postoperative Complications / Q000209:etiology
chemical_list: D007518:Isoantibodies; D005169:Factor VIII; D005164:Factor IX