[A preliminary observation on vitrectomy combined with autologous platelet concentrate for the treatment of idiopathic macular holes].
OBJECTIVE
To investigate the efficacy of vitrectomy combined with autologous platelet concentrate for the treatment of idiopathic macular holes.


METHODS
Fifteen eyes of 14 patients with idiopathic macular hole were treated. The follow-up period ranged from 3 to 16 months. Postoperatively, visual acuity, macular threshold, Amsler grid, fluorescein angiography (FA) and complications were evaluated.


RESULTS
Of the fifteen eyes, the closure of the holes was achieved in 13 eyes (86.7%), visual acuity improved for two lines or more in 12 eyes (80.0%). The postoperative visual acuities in patients with abnormal Amsler grid were improved. No significant differences were found in the macular threshold (P = 0.34). Postoperative FA showed that the blocked fluorescence at the site of the macular hole which was surrounded by a hyperfluorescence ring (window defect) in three eyes. The intraoperative complication was primarily the retinal hole, and the postoperative complication was chiefly the aggravation of cataract.


CONCLUSIONS
These results indicate that vitrectomy combined with autologous platelet concentrate can seal the macular hole well and improve the visual acuity in most patients. A large multicenter randomized prospective study and a longer period of follow-up are needed to verify these results.
Zhao
M
M
Department of Ophthalmology, People's Hospital, Beijing Medical University, Beijing 100044.
Li
X
X
Lü
Y
Y
Li
C
C
D001804:Blood Transfusion, Autologous; D006801:Humans; D007431:Intraoperative Complications / Q000209:etiology; D017713:Platelet Transfusion; D012167:Retinal Perforations / Q000209:etiology / Q000601:surgery*; D014792:Visual Acuity; D014821:Vitrectomy