[The effect of hyperoxic solution on acute myocardial hypoxia in scalded rabbits].
OBJECTIVE
To investigate the effects of hyperoxic solution on acute myocardial hypoxia in scalded rabbits.


METHODS
Rabbits inflicted with 30% TBSA III degree scald injury and/or acute myocardial ischemia were employed as the model. Animals were randomly divided into 4 groups, i.e. scalded rabbits treated with hyperoxic solution (A), scalded rabbits treated with normal saline (B), scalded rabbits without any treatment (C(b)) and normal healthy rabbits (C(h)). The cardiac function, blood rheology, blood gas analysis and the ratio of infarction to ischemic areas were dynamically monitored.


RESULTS
(1) The cardiac function of the rabbits in B group was evidently worse than that in C(h) group (P < 0.01) and A group (P < 0.05). (2) The whole blood viscosity in A, C(b) and especially B groups was obviously increased compared with that in C(h) group (P < 0.05). While the viscosity in A group was much lower than that in B group (P < 0.01), it was similar to that in C(b) group (P > 0.05). (3) The PO(2) in A group was significantly higher than that in B and C (C(b), C(h)) groups (P < 0.01). (4) The ratio of infarction to ischemic areas in A group was remarkably lower than that in B group (P < 0.01).


CONCLUSIONS
The hyperoxic solution may exert beneficial effects on acute myocardial ischemia in scalded rabbits. The mechanism might be related to the immediate correction of hypoxia in vital organs with simultaneous lowering of blood viscosity and the establishment of myocardial collateral circulation after the infusion of hyperoxic solution.
Jia
C
C
Department of Burn Surgery. Center of Plastic Surgery of PLA, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China.
Chen
B
B
Wang
Y
Y
D000818:Animals; D001809:Blood Viscosity; D002056:Burns / Q000097:blood / Q000150:complications*; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000628:therapy*; D010100:Oxygen / Q000627:therapeutic use*; D011817:Rabbits
D010100:Oxygen