title: Intensive care unit admission in patients with haematological disease: incidence, outcome and prognostic factors.
abstract: OBJECTIVE
  To examine incidence and outcome of intensive care unit (ICU) admission in patients with haematological malignancy and analyse prognostic factors associated with outcome.
  
  
  METHODS
  Retrospective cohort study in an intensive care unit of a tertiary referral center.
  
  
  METHODS
  78 patients with severe haematological malignancy were admitted 97 times between 1990-97 to the medical ICU for septic shock (18), respiratory failure (30), postoperative monitoring (19), cardiovascular (10) and central nervous complications (8) or for other reasons (12). Median age was 43 (4-73) years, average duration of ICU stay was 4 (1-43) days. Forty-two patients required mechanical ventilation, 46 vasopressors and 8 haemodialysis.
  
  
  RESULTS
  Rates of ICU admission differed by treatment of the underlying disease. There were 18, 10 and 27 ICU admissions per 100 treatments in patients undergoing chemotherapy for acute leukaemia, autologous and allogeneic stem cell transplantation (p <0.005) respectively. Thirty-two of 78 patients died within 60 days of ICU admission. Organ failure, i.e. cardiovascular failure requiring vasopressors, respiratory failure requiring mechanical ventilation and renal failure, requiring haemodialysis, was most significantly associated with outcome. Mortality by day 60 after admission was 16%, 36%, 64%, and 83% (p <0.0002) for patients without organ failure, and for patients with 1, 2 or 3 failing organs. In a multivariate logistical regression model, only the organ failure score (p <0.0005) and evidence of liver damage, defined as ASAT or ALAT >100 IU/ L (p <0.007), but not age, sex, primary disease and treatment of the underlying disease predicted outcome.
  
  
  CONCLUSIONS
  Multi-organ failure and evidence of liver damage but no other patient, disease, or treatment related factor predict outcome in patients with haematological disease admitted to the ICU.
authors.affiliation: Dept. of Internal Medicine, Kantonsspital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Evison
authors.forename: P
authors.initials: P
authors.lastname: Rickenbacher
authors.forename: R
authors.initials: R
authors.lastname: Ritz
authors.forename: A
authors.initials: A
authors.lastname: Gratwohl
authors.forename: C
authors.initials: C
authors.lastname: Haberthür
authors.forename: S
authors.initials: S
authors.lastname: Elsasser
authors.forename: J R
authors.initials: JR
authors.lastname: Passweg
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D003422:Critical Care / Q000706:statistics & numerical data*; D005260:Female; D019337:Hematologic Neoplasms / Q000401:mortality / Q000628:therapy; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D009102:Multiple Organ Failure / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D013223:Statistics as Topic; D016019:Survival Analysis; D016896:Treatment Outcome