Type I membranoproliferative glomerulonephritis in an HIV-infected individual without hepatitis C co-infection.
Type I membranoproliferative glomerulonephritis (MPGN) is an uncommon manifestation of human immunodeficiency virus (HIV)-associated renal disease in patients co-infected with hepatitis C virus (HCV). We describe a case of Type I MPGN in an HIV-positive diabetic man with nephrotic-range proteinuria and renal insufficiency who was not co-infected with HCV. Tubuloreticular inclusions were present but there was no evidence for either cryoglobulinemia or cryoglobulin deposits in the kidney. This finding suggests that Type I MPGN may represent a reaction of the kidney to HIV independent of the effects of HCV co-infection. Clinical suspicion must be maintained for Type I MPGN in all HIV infected patients presenting with significant proteinuria regardless of HCV infection status.
Chidambaram
M
M
Department of Medicine, St Michael's Hospital, University of Toronto, Ontario, Canada.
Stigant
C E
CE
Sugar
L M
LM
Ramesh Prasad
G V
GV
D016263:AIDS-Associated Nephropathy / Q000175:diagnosis* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis* / Q000473:pathology; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged