Is there a relationship between left ventricular systolic function and serum cytokines level in patients with coronary artery disease?
BACKGROUND
There is growing evidence that cytokines play a pathogenic role in both heart failure and atherosclerosis. The aim of our study was to assess serum levels of selected cytokines and soluble forms of receptors in patients with coronary artery disease (CAD), and the relation between these concentrations and left ventricular (LV) systolic function.


METHODS
We measured serum levels of TNFalpha, sTNFR 1 and 2, IL-2, and IL-10 in 100 patients with CAD: 70 patients with LV regional wall motion disturbances (group A); and 30 patients with normal LV function (group B). The control group (group C) consisted of 20 healthy volunteers.


RESULTS
Mean serum TNFalpha and IL-10 concentrations were significantly higher in groups A (18.3 +/- 3.5; 55.4 +/- 118.5 pg/ml) and B (17.9 +/- 4.9; 45.3 +/- 76.8 pg/ml) than in controls (8.3 +/- 1.4, p<0.001; 14.3 +/- 28.5, p<0.05; respectively). Moreover, in group A serum levels of sTNFR 1 were higher (1367.4 +/- 531.1 pg/ml) than in group C (1093.9 +/- 456.9 pg/ml; p<0.05). No differences were found in the study groups between serum sTNFR 2 and IL-2 levels. In group A, both the LV ejection fraction and motion score index correlated with TNFalpha (r=-0.277; r=0.282; p<0.05), and sTNFR 1 levels (r=-0.258; r=0.280; p < 0.05).


CONCLUSIONS
The serum concentrations of TNFalpha and IL-10 are increased in patients with CAD. Additionally, patients with impaired LV contractility have higher sTNFR 1 concentrations. Serum cytokine activation may play a role in the development of heart failure in patients with CAD.
Mizia-Stec
Katarzyna
K
2nd Department of Cardiology; Silesian University School of Medicine, ul. Ziołowa 45/47, 40-635 Katowice, Poland. biboch@slam.katowice.pl
Mandecki
Tadeusz
T
Zahorska-Markiewicz
Barbara
B
Janowska
Joanna
J
Szulc
Andrzej
A
Jastrzebska-Maj
Ewa
E
Szymański
Leszek
L
D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology*; D016207:Cytokines / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D016277:Ventricular Function, Left
D016207:Cytokines; D014280:Triglycerides; D002784:Cholesterol