[Antipublic antibodies and pregnancy: use of iron sucrose in autologous blood donation with cryopreservation].
An autologous blood donation with cryopreservation in a pregnant woman with natural antibody against a high frequency alloantigen is reported. A natural anti Gerbich antibody and a rare erythrocyte phenotype at high risk of polyimmunization was discovered during the third month of pregnancy. This leads to recommend the constitution of an autologous blood reserve. Before first sampling a moderate iron deficiency anaemia (10.3 g.dL-1) was treated with 600 mg of intravenous iron sucrose. Four blood packs of 350 mL were taken; after every sampling 200 mg of iron sucrose were injected intravenously. No maternal or foetal adverse effects occurred. Five weeks before delivery, an autologous blood reserve consisting in 4 cryopreserved red cells packs and 4 fresh frozen plasma was constituted. Epidural analgesia was used for delivery. No haemorrhage occurred. The reserve was not used and remained available for future use (one year for fresh frozen plasma and without limit for red cells).
Bayoumeu
F
F
Service d'anesthésie-réanimation, maternité régionale, rue du Dr Heydenreich, 54042 Nancy, France.
Vial
F
F
Zaccabri
A
A
Agullès
O
O
Laxenaire
M C
MC
D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood* / Q000188:drug therapy*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001793:Blood Preservation; D001804:Blood Transfusion, Autologous; D015925:Cryopreservation; D005260:Female; D005290:Ferric Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid; D006801:Humans; D007231:Infant, Newborn; D007275:Injections, Intravenous; D007501:Iron / Q000097:blood; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy* / Q000276:immunology
D001323:Autoantibodies; D005290:Ferric Compounds; D007501:Iron; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid