title: Synthesis and antiplatelet activity of gemfibrozil chiral analogues.
abstract: The chiral analogues of gemfibrozil 5-(2,5-dimethylphenoxy)-2-methylpentanoic acid and 5-(2,5-dimethylphenoxy)-2-ethylpentanoic acid were synthesized in optically active form using (S)-4-(1-methylethyl)-2-oxazolidinone as chiral auxiliary. All compounds inhibit human platelet aggregation. From these data, one can surmise that all tested compounds and gemfibrozil act at the platelet level with different mechanism than that of ASA, even if with a different potency.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università degli Studi G. D'Annunzio, Via dei Vestini, 66100, Chieti, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ammazzalorso
authors.forename: Rosa
authors.initials: R
authors.lastname: Amoroso
authors.forename: Mario
authors.initials: M
authors.lastname: Baraldi
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Bettoni
authors.forename: Daniela
authors.initials: D
authors.lastname: Braghiroli
authors.forename: Barbara
authors.initials: B
authors.lastname: De Filippis
authors.forename: Andrea
authors.initials: A
authors.lastname: Duranti
authors.forename: Marco
authors.initials: M
authors.lastname: Moretti
authors.forename: Paolo
authors.initials: P
authors.lastname: Tortorella
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Tricca
authors.forename: Francesca
authors.initials: F
authors.lastname: Vezzalini
mesh_terms: D001792:Blood Platelets / Q000187:drug effects*; D015248:Gemfibrozil / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D015394:Molecular Structure; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C461199:5-(2,5-dimethylphenoxy)-2-ethylpentanoic acid; C461198:5-(2,5-dimethylphenoxy)-2-methylpentanoic acid; D010975:Platelet Aggregation Inhibitors; D015248:Gemfibrozil