title: Tumour suppressor genes in sporadic epithelial ovarian cancer.
abstract: Ovarian cancer is the most frequent cause of death from gynaecological malignancies in the western world, and sporadic epithelial ovarian cancer is its most predominant form. The aetiology of sporadic ovarian cancer remains unknown. Genetic studies have enabled a better understanding of the evolution of tumour progression. A major focus of research has been to identify tumour suppressor genes implicated in sporadic ovarian cancer over the past decade. Several tumour suppressor genes have been identified by strategies such as positional cloning and differential expression display. Further research is warranted to understand fully their contribution to the pathogenesis of sporadic ovarian cancer.
authors.affiliation: ICRF Molecular Oncology Laboratories, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Trivadi S
authors.initials: TS
authors.lastname: Ganesan
mesh_terms: D019313:BRCA1 Protein / Q000235:genetics; D002277:Carcinoma / Q000235:genetics*; D002875:Chromosomes; D020732:Cytogenetic Analysis; D005260:Female; D016147:Genes, Tumor Suppressor; D018095:Germ-Line Mutation; D006801:Humans; D019656:Loss of Heterozygosity; D010051:Ovarian Neoplasms / Q000235:genetics*; D014960:X Chromosome
chemical_list: D019313:BRCA1 Protein