Azathioprine intolerance in patients with IBD may be imidazole-related and is independent of TPMT activity.
McGovern
D P B
DP
Travis
S P L
SP
Duley
J
J
Shobowale-Bakre
El M
el M
Dalton
H R
HR
D001379:Azathioprine / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects / Q000493:pharmacokinetics; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000378:metabolism*; D008780:Methyltransferases / Q000378:metabolism*
D007093:Imidazoles; D007166:Immunosuppressive Agents; D008780:Methyltransferases; C022745:thiopurine methyltransferase; D001379:Azathioprine