title: Apoptosome: the seven-spoked death machine.
abstract: A paper in the February issue of Molecular Cell describes the structure of the apoptosome, a multicomponent death machine, deciphered by cryoelectron microscopy. This structure explains the assembly of the machine, the tentative location of the subcomponents, and proposes a mechanism for initiating the death signal.
authors.affiliation: Program in Apoptosis and Cell Death Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Guy S
authors.initials: GS
authors.lastname: Salvesen
authors.forename: Martin
authors.initials: M
authors.lastname: Renatus
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000378:metabolism*
chemical_list: D020169:Caspases