title: Patient safety technology for microadsorbent systems in extracorporeal blood purification.
abstract: Alternative technologies for extracorporeal blood purification systems based on microadsorbents in suspension are discussed. Principally, microadsorbents offer higher efficiency and flexibility when compared to conventional column-based adsorption systems. Systems already clinically employed (e.g., BioLogic DT) or close to clinical application (e.g., the microspheres-based detoxification system, MDS) are described. The MDS technology, in particular, is characterized by efficiency and a high degree of flexibility with respect to both the use of different adsorbents as well as the combination with hemodialysis/hemofiltration therapy. It was designed for continuous use in intensive-care units, but enables also the removal of low-density lipoprotein, fibrinogen, autoimmune antibodies, immune complexes, and other pathophysiologically relevant substances. Alternative anticoagulation regimes and safety systems on fluorescence sensor technology have recently been developed for the MDS and are presented in this paper.
authors.affiliation: C. Doppler Institute for Adsorption Technology in Medicine, Danube University, Krems, Austria.
authors.forename: D
authors.initials: D
authors.lastname: Falkenhagen
authors.forename: W
authors.initials: W
authors.lastname: Strobl
authors.forename: J
authors.initials: J
authors.lastname: Hartmann
authors.forename: A
authors.initials: A
authors.lastname: Schrefl
authors.forename: I
authors.initials: I
authors.lastname: Linsberger
authors.forename: K-H
authors.initials: KH
authors.lastname: Kellner
authors.forename: F
authors.initials: F
authors.lastname: Aussenegg
authors.forename: A
authors.initials: A
authors.lastname: Leitner
mesh_terms: D000327:Adsorption; D002606:Charcoal; D005112:Extracorporeal Circulation; D006801:Humans; D008567:Membranes, Artificial; D008863:Microspheres; D006435:Renal Dialysis; D016060:Sorption Detoxification
chemical_list: D008567:Membranes, Artificial; D002606:Charcoal