[Preformulation study of atenolol-containing solutions.. I. The pH dependence of thermostability].
The stability of atenolol solutions was evaluated under accelerated isothermal degradation conditions at 90 degrees C. A specific and sensitive HPLC method was adapted to study the pH dependence of the stability. The maximum stability of atenolol was achieved at pH 4 with a k value of 1.1 x 10(-3) h-1. The degradation of atenolol followed first-order kinetics at above mentioned conditions.
Marton
S
S
Semmelweis Egyetem Budapest, Gyógyszerészeti Intézet 1092 Budapest, Hógyes E. u. 7.
Hatem
A
A
Csóka
G
G
Rácz
I
I
D001262:Atenolol / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D012996:Solutions
D012996:Solutions; D001262:Atenolol