title: Therapeutic activity of NK cells against tumors.
abstract: While it is generally accepted that natural killer (NK) cells, by killing tumor cells in the circulation, represent a first line of defense against metastases, their therapeutic activity against established tumors has been limited. In this review, we describe studies to improve the therapeutic effectiveness of activated NK cells in both animal models and clinical trials to better understand the biological problems that limit their effectiveness.
authors.forename: P H
authors.initials: PH
authors.lastname: Basse
authors.forename: T L
authors.initials: TL
authors.lastname: Whiteside
authors.forename: W
authors.initials: W
authors.lastname: Chambers
authors.forename: R B
authors.initials: RB
authors.lastname: Herberman
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D005910:Glioma / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D007694:Killer Cells, Natural / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy