Studies on cancer chemoprevention by traditional folk medicines XXIV. Inhibitory effect of a coumarin derivative, 7-isopentenyloxycoumarin, against tumor-promotion.
7-Isopentenyloxycoumarin (1) was isolated from Heracleum lanatum MICHX. (Umbelliferae). Compound 1 inhibited phospholipid metabolism and Epstein-Barr virus activation caused by a potent tumor promoter. In an in vivo experiment, topical application of 1 suppressed skin-tumor-formation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene (DMBA) initiated mice. And it also suppressed ornithine decarboxylase activity stimulated by TPA on mouse skin. These results indicated that 7-isopentenyloxycoumarin is one of the effective compounds from natural resources for treating skin tumor formation.
Baba
Masaki
M
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan.
Jin
Yongri
Y
Mizuno
Atsuo
A
Suzuki
Hisaya
H
Okada
Yoshihito
Y
Takasuka
Nobuo
N
Tokuda
Harukuni
H
Nishino
Hoyoku
H
Okuyama
Toru
T
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D005260:Female; D006367:HeLa Cells; D030002:Heracleum; D004854:Herpesvirus 4, Human / Q000187:drug effects; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D065108:Ornithine Decarboxylase Inhibitors; D008517:Phytotherapy; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D014775:Virus Activation / Q000187:drug effects
C461443:7-isopentenyloxycoumarin; D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D065108:Ornithine Decarboxylase Inhibitors