[Effects of maternal toxic hepatitis on the postnatal development of duodenal morphology of their offspring].
Retardation has been shown in development and formation of the vascular-and-tissue structures of white rat younglings (3, 7, 14, 21, 30 days old) born to mothers with chronic heliotrine hepatitis in the duodenum versus control animals. In the duodenal mucosa, the villi are short, their shape lost, the mucosal muscular plate development returded. Noted in the epithelium are distrophic changes, a decline in the epithelial cell mitotic activity. The intraorgan blood vessels are dilated and blood-filled. There are spots of extravasation.
Bazhakova
D B
DB
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001808:Blood Vessels / Q000187:drug effects / Q000473:pathology; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000235:genetics / Q000503:physiopathology*; D004386:Duodenum / Q000098:blood supply / Q000187:drug effects / Q000254:growth & development / Q000473:pathology*; D005314:Embryonic and Fetal Development / Q000187:drug effects; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D008431:Maternal-Fetal Exchange; D008938:Mitosis / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011763:Pyrrolizidine Alkaloids / Q000494:pharmacology; D051381:Rats
D011763:Pyrrolizidine Alkaloids; C010178:heliotrine