title: Microalbuminuria as a marker of cardiac damage in essential hypertension.
abstract: A subclinical elevation in urinary albumin excretion (UAE) microalbuminuria is frequently seen in essential hypertension. The level of blood pressure appears to be an important factor in the development of microalbuminuria. Moreover there is some evidence to indicate that microalbuminuria may be an early marker of increased cardiovascular risk. Aim of this study was to evaluate the prevalence of UAE in hypertensives with normal left ventricular mass and to study any association with blood pressure level and with possible modification in left ventricular function. A group of 112 subjects diagnosed as having stage 1-2 essential hypertension were included in the study. Patients underwent urinary collection to evaluate UAE and to 24/hours arterial blood pressure monitoring. Moreover a complete echocardiography was performed. According with UAE levels patients were divided into three groups: A: UAE 0-15 mg/24 h, B: UAE 16-29 mg/24 h, C: UAE 30-300 mg/24 h. We found a significant correlation between 24/h SBP, 24/h DBP and UAE. We observed a significant correlation between impaired diastolic function and UAE. UAE is influenced by BP levels with better correlation with 24/h systolic values. UAE is associated with subclinical decrease of left ventricular function and may be an early marker of cardiac involvement.
authors.affiliation: Istituto Patologia Medica, Center for the Study of Hypertension, Catholic University Medical School, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mettimano
authors.forename: M L
authors.initials: ML
authors.lastname: Specchia
authors.forename: A
authors.initials: A
authors.lastname: Migneco
authors.forename: L
authors.initials: L
authors.lastname: Savi
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000453:epidemiology / Q000503:physiopathology / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D015995:Prevalence; D012044:Regression Analysis; D018487:Ventricular Dysfunction, Left / Q000652:urine
chemical_list: D015415:Biomarkers