Transcription: surprising role for an elusive small nuclear RNA.
Since 7SK was discovered as an abundant small nuclear RNA in the mid-70s, its role has remained tantalizingly unsolved. Two recent studies have shown that 7SK acts as a negative regulator of the RNA polymerase II elongation factor P-TEFb, and that this activity is influenced by stress response pathways.
Blencowe
Benjamin J
BJ
Banting and Best Department of Medical Research, C.H. Best Institute, University of Toronto, 112 College Street, Room 410, Ontario, M5G 1L6, Toronto, Canada. b.blencowe@utoronto.ca
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D042925:Positive Transcriptional Elongation Factor B; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D012319:RNA Polymerase II / Q000378:metabolism; D012342:RNA, Small Nuclear / Q000235:genetics*; D013312:Stress, Physiological / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics*
D012342:RNA, Small Nuclear; D042925:Positive Transcriptional Elongation Factor B; D017346:Protein Serine-Threonine Kinases; D012319:RNA Polymerase II