title: Metal-associated angiosarcoma of bone: report of two cases and review of the literature.
abstract: Angiosarcoma is an extremely rare bone tumor. The authors report two cases of patients with angiosarcoma that developed adjacent to a stainless steel plate used for fixation of a femur fracture. In both patients, the interval between fracture treatment and the development of the neoplasm was more than 40 years. A review of the literature found 36 previously reported cases of malignancy arising adjacent to an orthopaedic implant. Despite any evidence directly linking these implants to the development of cancer, continued vigilance is warranted.
authors.affiliation: Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, St. Louis, MO 63110, USA.
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: McDonald
authors.forename: William F
authors.initials: WF
authors.lastname: Enneking
authors.forename: Murali
authors.initials: M
authors.lastname: Sundaram
mesh_terms: D000368:Aged; D001860:Bone Plates / Q000009:adverse effects*; D005264:Femoral Fractures / Q000601:surgery; D005266:Femoral Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D005593:Fracture Fixation, Internal / Q000009:adverse effects / Q000295:instrumentation; D006394:Hemangiosarcoma / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D011859:Radiography; D013193:Stainless Steel / Q000009:adverse effects*
chemical_list: D013193:Stainless Steel