A left ventricle model to predict post-revascularization ejection fraction based on cine magnetic resonance images.
The left ventricular ejection fraction (LVEF) is an important clinical indicator of the cardiac function and long-term outcome for patients with coronary artery disease. A biomechanical model of the left ventricle was developed to quantitatively predict post-revascularization LVEF based on noninvasive magnetic resonance imaging. The myocardium was categorized into normal, hibernating, and infarcted regions from the ventricular short-axis images. Assuming that hibernating tissue would potentially regain contractility after revascularization, the expected maximum post-revascularization LVEF was calculated for four patients with chronic left ventricular dysfunction. The predictions were within three ejection fraction points of the follow-up LVEFs. This model may be useful to estimate the outcome and efficacy of revascularization plans.
Han
Hai-Chao
HC
School of Mechanical Engineering, Georgia Institute of Technology, Atlanta 30332-0405, USA. haichao.han@me.gatech.edu
Oshinski
John N
JN
Ku
David N
DN
Pettigrew
Roderic I
RI
D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D019028:Magnetic Resonance Imaging, Cine; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D009204:Myocardial Revascularization / Q000009:adverse effects; D009206:Myocardium / Q000473:pathology; D011237:Predictive Value of Tests; D013318:Stroke Volume / Q000502:physiology; D014022:Tissue Survival; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology / Q000601:surgery