ABO-incompatible auxiliary partial orthotopic liver transplant for late-onset familial amyloid polyneuropathy.
A 60-year-old Japanese man with late-onset familial amyloid polyneuropathy type I (FAP transthyretin Met30) showed clinical improvement following auxiliary partial orthotopic liver transplantation (APOLT) from an ABO-incompatible living related donor. Preoperatively, plasmapheresis and immunosuppressant drugs were used to reduce serum antibodies against the donor's ABO type. APOLT was chosen so the residual liver could sustain the patient in the event of hyperacute rejection. OLT is applicable to late-onset FAP transthyretin Met30, and APOLT can be considered in ABO-incompatible cases.
Watanabe
H
H
Department of Neurology, Nagoya University Graduate School of Medicine, 466-8550, Nagoya, Japan.
Misu
K
K
Kobayashi
T
T
Hattori
N
N
Doyu
M
M
Yokoyama
I
I
Ando
Y
Y
Nakao
A
A
Sobue
G
G
D000017:ABO Blood-Group System; D028227:Amyloid Neuropathies, Familial / Q000097:blood* / Q000601:surgery*; D001787:Blood Group Incompatibility; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D011300:Preoperative Care
D000017:ABO Blood-Group System; D007166:Immunosuppressive Agents