[Participation of final products of lipid peroxidation in the anticancer mechanism of ionizing radiation and radiomimetic cytostatics].
This review reports the evidence for the participation of final products of lipid peroxidation in the anticancer mechanism of ionising radiation and radiomimetic cytostatics. Processes of lipid peroxidation occur endogenously in response to oxidative stress and great diversity of reactive metabolites is formed. However, direct observation of radical reaction in pathophysiology of cells, tissues and organs is limited technically. Most investigations focused on the indirect assessment of their final products, aldehydes. The peroxidative breakdown of polyunsaturated fatty acids is believed to be involved in the regulation of cell division, and antitumor effect through biochemical and genetic processes.
Przybyszewski
W M
WM
Centrum Onkologii, Instytut im. M. Skłodowskiej-Curie, Oddział w Gliwicach.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005609:Free Radicals / Q000528:radiation effects; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects*; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy; D018384:Oxidative Stress; D011839:Radiation, Ionizing
D000970:Antineoplastic Agents; D005231:Fatty Acids, Unsaturated; D005609:Free Radicals