title: Ischemic preconditioning reduces infarct volume after subdural hematoma in the rat.
abstract: The aim of the present study was to investigate the effects of ischemic preconditioning on infarct volume in a rat model of subdural hematoma (SDH). Ischemic preconditioning was induced by 15 min transient middle cerebral artery (MCA) occlusion followed 3 days later by the injection of 300 microl of autologous venous blood into the subdural space. Preconditioning significantly reduced the volume of cortical infarction (by 26%, P<0.001) 24 h after SDH induction, but not brain swelling (P>0.05) relative to sham-operated non-preconditioned animals. These data support the view that ischemic preconditioning reduces ischemic brain damage in this rat model of SDH.
authors.affiliation: Neurocrine Biosciences Inc., 10555 Science Center Drive, San Diego, CA 92121-1102, USA. kmackay@neurocrine.com
authors.forename: Kenneth B
authors.initials: KB
authors.lastname: Mackay
authors.forename: Theodore H
authors.initials: TH
authors.lastname: Stiefel
authors.forename: Alan C
authors.initials: AC
authors.lastname: Foster
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D020520:Brain Infarction / Q000473:pathology* / Q000517:prevention & control*; D006408:Hematoma, Subdural / Q000473:pathology* / Q000517:prevention & control*; D019194:Ischemic Preconditioning; D008297:Male; D020768:Middle Cerebral Artery / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley