CtBP, an unconventional transcriptional corepressor in development and oncogenesis.
CtBP family proteins are conserved among vertebrates and invertebrates and function as transcriptional corepressors. They repress transcription in a histone deacetylase-dependent or -independent manner. CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed.
Chinnadurai
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Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, St. Louis, MO 63110, USA. chinnag@slu.edu
D000107:Acetylation; D017500:Adenovirus E1A Proteins / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000737:chemistry; D020816:Amino Acid Motifs; D000818:Animals; D019313:BRCA1 Protein / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D000074008:MDS1 and EVI1 Complex Locus Protein; D046911:Macromolecular Substances; D009857:Oncogenes; D010750:Phosphoproteins / Q000737:chemistry / Q000502:physiology*; D010766:Phosphorylation; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D011518:Proto-Oncogene Proteins / Q000502:physiology; D011519:Proto-Oncogenes; D012097:Repressor Proteins / Q000737:chemistry / Q000145:classification; D016160:Retinoblastoma Protein / Q000502:physiology; D014157:Transcription Factors; D014158:Transcription, Genetic; D014714:Vertebrates / Q000235:genetics / Q000378:metabolism; D051153:Wnt Proteins; D014982:Xenopus laevis / Q000196:embryology / Q000235:genetics; D029961:Zebrafish Proteins; D018631:ras Proteins / Q000502:physiology
D017500:Adenovirus E1A Proteins; D019313:BRCA1 Protein; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D006657:Histones; D000074008:MDS1 and EVI1 Complex Locus Protein; C063575:MECOM protein, human; D046911:Macromolecular Substances; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D016160:Retinoblastoma Protein; D014157:Transcription Factors; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D000429:Alcohol Oxidoreductases; C083779:2-hydroxyacid dehydrogenase; C096794:C-terminal binding protein; D006655:Histone Deacetylases; D018631:ras Proteins