Copper(II) complexes of the beta-blocker pindolol: properties, structure, biological activity.
The complex formation between copper(II) and the antihypertensive drug pindolol (HPin) was studied both in aqueous and methanolic media. Two complexes are formed at different metal-to-ligand molar ratios. The mononuclear complex Cu(Pin)2(HPin)2 contains two ligands in an anionic bidentate form and two--in a neutral form bound monodentately. The second complex Cu2Pin2Cl2 is dinuclear and its structure was determined by X-ray diffraction. The compound crystallizes in the monoclinic group C2/c with cell components a = 14.4998(13)A, b = 18.511(2)A, c = 14.2982(13)A, alpha = 90 degrees, beta = 109.556(2) degrees, gamma = 90 degrees and Z = 12 at 293K. A pharmacological study on the influence of pindolol and its mononuclear complex on the heart rate of rats was performed. The complex is more active and has a longer effect in comparison with the pure non-coordinated pindolol in equitoxic doses.
Bontchev
Panayot R
PR
Faculty of Chemistry, Sofia University, Bulgaria. prbontchev@chem.uni-sofia.bxg
Pantcheva
Ivayla N
IN
Bontchev
Ranko P
RP
Ivanov
Darvin S
DS
Danchev
Nikolay D
ND
D000319:Adrenergic beta-Antagonists / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006339:Heart Rate / Q000187:drug effects; D008024:Ligands; D008297:Male; D000432:Methanol; D008958:Models, Molecular; D015394:Molecular Structure; D010869:Pindolol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions; D014867:Water
D000319:Adrenergic beta-Antagonists; D008024:Ligands; D012996:Solutions; D014867:Water; D003300:Copper; D010869:Pindolol; D000432:Methanol