title: Comparative analysis of the human dystrophin and utrophin gene structures.
abstract: We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.
authors.affiliation: IRCCS E. Medea, Associazione La Nostra Famiglia, 23842 Bosisio Parini, LC, Italy. msironi@bp.lnf.it
authors.forename: Uberto
authors.initials: U
authors.lastname: Pozzoli
authors.forename: Manuela
authors.initials: M
authors.lastname: Sironi
authors.forename: Rachele
authors.initials: R
authors.lastname: Cagliani
authors.forename: Giacomo P
authors.initials: GP
authors.lastname: Comi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bardoni
authors.forename: Nereo
authors.initials: N
authors.lastname: Bresolin
mesh_terms: D003598:Cytoskeletal Proteins / Q000235:genetics*; D016189:Dystrophin / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics*; D022821:RNA Splice Sites / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D049411:Utrophin
chemical_list: D003598:Cytoskeletal Proteins; D016189:Dystrophin; D008565:Membrane Proteins; D022821:RNA Splice Sites; C483599:UTRN protein, human; D049411:Utrophin