Ischemia-reperfusion injury of the liver with special reference to calcium-dependent mechanisms.
Ischemia-reperfusion (I/R) injury is a complex process involving numerous intracellular signaling pathways, mediators, cells, and pathophysiological disturbances; its prevention during liver surgery is of utmost importance. In this review, we divide hepatic I/R injury into two phases, intracellular and extracellular, for a better understanding of the processes involved. Ca2+ and Ca2+-dependent reactions play an important role as a trigger in the former phase, while the subsequent generation of bioactive substances plays a predominant role in the latter phase. These findings indicate that a combination of different therapeutic approaches against Ca2+-dependent steps may help prevent I/R injury of the liver.
Sakon
Masato
M
Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Ariyoshi
Hideo
H
Umeshita
Koji
K
Monden
Morito
M
D017209:Apoptosis; D002118:Calcium / Q000502:physiology*; D002154:Calpain / Q000502:physiology; D002450:Cell Communication; D002470:Cell Survival; D006801:Humans; D008099:Liver / Q000098:blood supply* / Q000601:surgery; D009504:Neutrophils; D015427:Reperfusion Injury / Q000378:metabolism* / Q000517:prevention & control
D002154:Calpain; D002118:Calcium