The synthesis and biological characterization of a ceramide library.
A facile synthesis of a combinatorial ceramide library and their activities in the NF-kappaB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-kappaB activating molecule was discovered among ceramide containing beta-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated.
Chang
Young-Tae
YT
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, San Diego, California 92037, USA.
Choi
Jaehwa
J
Ding
Sheng
S
Prieschl
Eva E
EE
Baumruker
Thomas
T
Lee
Jae-Mok
JM
Chung
Sung-Kee
SK
Schultz
Peter G
PG
D017209:Apoptosis / Q000187:drug effects; D002518:Ceramides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000502:physiology; D020650:Combinatorial Chemistry Techniques; D006801:Humans; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D020298:U937 Cells
D002518:Ceramides