title: Cellular and molecular basis of age-related sarcopenia.
abstract: Sarcopenia, the decline in muscle bulk and performance associated with normal aging, is an important component of frailty in the elderly. The gradual loss of both motor nerves and muscle fibers during senescence appears to be the major problem. Atrophy (especially in fast-twitch fibers) and impaired function of the surviving cells also contribute to sarcopenia. Although skeletal muscle has the capacity to regenerate itself, this process is not activated by the gradual age-related loss of muscle fibers. The endocrine, autocrine, and paracrine environment in old muscle is less supportive of protein synthesis, reinnervation of muscle fibers, and satellite cell activation, proliferation, and differentiation. Lifelong exposure of DNA to free radical damage results in accumulation of somatic mutations in nerves and muscle fibers. Reduced protein synthesis leads to atrophy, and slower fractional protein turnover contributes to longer retention of proteins that may have been damaged by free radicals. Many genes are differentially expressed in young and old muscle, but additional research is needed to determine which of these genes have a significant role in the pathogenesis or adaptation to sarcopenia.
authors.affiliation: Department of Medicine, University of Rochester, Rochester, New York 14642, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Welle
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D016207:Cytokines / Q000502:physiology; D015870:Gene Expression; D006728:Hormones / Q000502:physiology; D006801:Humans; D009046:Motor Neurons / Q000502:physiology; D018656:Muscle Fibers, Fast-Twitch / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D009133:Muscular Atrophy / Q000235:genetics / Q000503:physiopathology*
chemical_list: D016207:Cytokines; D006728:Hormones