title: Macrovascular disease risk factors and insulin resistance in Aboriginal and Torres Strait Islander people.
abstract: It has been proposed that insulin resistance (IR) underlies a cluster of cardiovascular disease (CVD) risk factors constituting a "metabolic syndrome." CVD is a leading cause of premature mortality among indigenous Australians. In a group of younger (15-44 years, fasting glucose <7.8 mmol/l) Aboriginal (n=643) and Torres Strait Islander (n=220) people participating in community-based risk factor surveys, we identified high prevalences of metabolic syndrome components: glucose intolerance, dyslipidaemia, hypertension, and IR. There were inconsistent associations of IR with other risk factors, and the data do not support a direct causal relationship between insulin and other metabolic variables. Rather, metabolic syndrome components may arise from social and environmental factors interacting with behavioural and biochemical factors in individuals.
authors.affiliation: Menzies School of Health Research, Tiwi NT 8010, Australia. kerin@menzies.edu.au
authors.forename: Kerin
authors.initials: K
authors.lastname: O'Dea
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Rowley
mesh_terms: D000293:Adolescent; D000328:Adult; D001315:Australia / Q000453:epidemiology; D001786:Blood Glucose / Q000378:metabolism; D016000:Cluster Analysis; D005260:Female; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008954:Models, Biological; D015995:Prevalence; D012307:Risk Factors; D014652:Vascular Diseases / Q000453:epidemiology* / Q000503:physiopathology
chemical_list: D001786:Blood Glucose; D007328:Insulin