title: Outcomes of naltrexone maintenance following ultra rapid opiate detoxification versus intensive inpatient detoxification.
abstract: Relapse rates of 30 opiate-addicted social service clients who were given a 9-month course of naltrexone after being rapidly detoxified using naltrexone + clonidine under anesthesia were compared to 33 similar clients detoxified in a 30-day intensive inpatient detoxification but not given naltrexone. Both groups had the same counseling aftercare. Telephone follow-up of 26 of the intensive inpatient detoxification clients and 24 of the rapidly detoxified clients found no significant differences (p = .62) in relapse rates, with 34% of respondents returning to regular opiate use 13.4 (+/- 3.8) months after detoxification. Naltrexone maintenance and counseling following rapid detoxification may be as effective as intensive inpatient detoxification and counseling.
authors.affiliation: School of Social Work, Bar Ilan University, Ramat Gan, Israel. rabinowz@mail.biu.ac.il
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rabinowitz
authors.forename: Hagit
authors.initials: H
authors.lastname: Cohen
authors.forename: Shmuel
authors.initials: S
authors.lastname: Atias
mesh_terms: D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008658:Inactivation, Metabolic; D007557:Israel; D008297:Male; D009271:Naltrexone / Q000008:administration & dosage / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D009293:Opioid-Related Disorders / Q000188:drug therapy*; D010349:Patient Compliance; D012008:Recurrence; D012189:Retrospective Studies; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D009292:Narcotic Antagonists; D009271:Naltrexone; D003000:Clonidine