title: Enhanced expression of iNOS intratumorally and at the immunization site after immunization with IFNgamma-secreting rat glioma cells.
abstract: Nitric oxide (NO) can modulate both tumor growth and antitumor immune responses. In order to elucidate the mechanism of curative therapeutic immunization with IFNgamma-producing glioma cells, we examined the expression of inducible nitric oxide synthase (iNOS) in tissue sections from immunized animals. There was a significantly enhanced iNOS expression both intratumorally and at the immunization site. Although the mechanisms behind this dual expression of iNOS most probably are different, our results suggest a role for NO in both the induction and execution of the antitumor response.
authors.affiliation: Section for Tumor Immunology, Department of Cell and Molecular Biology, University of Lund, BMC I12, 221 84, Lund, Sweden. Anna.Johansson@wblab.lu.se
authors.forename: Anna C
authors.initials: AC
authors.lastname: Johansson
authors.forename: Pontus
authors.initials: P
authors.lastname: Hegardt
authors.forename: Shorena
authors.initials: S
authors.lastname: Janelidze
authors.forename: Edward
authors.initials: E
authors.lastname: Visse
authors.forename: Bengt
authors.initials: B
authors.lastname: Widegren
authors.forename: Peter
authors.initials: P
authors.lastname: Siesjö
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000201:enzymology* / Q000276:immunology; D002478:Cells, Cultured; D005910:Glioma / Q000276:immunology*; D007114:Immunization; D007371:Interferon-gamma / Q000096:biosynthesis*; D008198:Lymph Nodes / Q000201:enzymology; D008297:Male; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D052247:Nitric Oxide Synthase Type II; D010587:Phagocytosis; D051381:Rats; D011916:Rats, Inbred F344; D012867:Skin / Q000201:enzymology; D013154:Spleen / Q000201:enzymology
chemical_list: D009569:Nitric Oxide; D007371:Interferon-gamma; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat