Contribution of efflux pump activity to the delivery of pulmonary therapeutics.
To date, there are few in vitro models of the human lung that have been used to characterize multidrug resistant (MDR) efflux pump activity. It is expected that the presence of these protein transporter molecules, such as P-glycoprotein (Pgp) and the multidrug resistance protein associated protein-1 (MRP1), might play a role in limiting drug absorption through the pulmonary epithelium, as has been reported for other epithelial drug delivery barriers such as the intestine and brain. To date, the exact role of the lung resistance related protein (LRP) in MDR is unclear. In this article, we have summarized the biochemistry, function and in vitro/in vivo modulation of Pgp and MRP1. These topics are discussed in light of pulmonary delivery of therapeutic agents, with particular emphasis being placed on the bronchial region of human airways.
Hamilton
K O
KO
Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence 66047-3729, USA.
Yazdanian
M A
MA
Audus
K L
KL
D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology*; D016503:Drug Delivery Systems; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008171:Lung Diseases / Q000188:drug therapy* / Q000378:metabolism