Dictyterpenoids A and B, two novel diterpenoids with feeding-deterrent activity from the brown alga Dilophus okamurae.
In our continuing efforts to study the presence of biologically active compounds that control seaweed-herbivore interactions, we examined the presence of such chemicals in freshly collected Dilophus okamurae Dawson. Our results demonstrated the presence of two diterpenoids, named dictyterpenoid A (1) and dictyterpenoid B (2), having a novel carbon skeleton, along with 10 known diterpenes, 3-12. The structures of these novel metabolites were elucidated by spectroscopic and chemical methods. The isolated compounds showed feeding-deterrent activity against the young abalone Haliotis discus hannai.
Suzuki
Minoru
M
Division of Material Science, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan. misu@ees.hokudai.ac.jp
Yamada
Hiroko
H
Kurata
Kazuya
K
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects*; D007564:Japan; D008968:Molecular Conformation; D015394:Molecular Structure; D008974:Mollusca / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D000459:Phaeophyceae / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
D004224:Diterpenes; C451132:dictyterpenoid A; C451133:dictyterpenoid B