title: Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis.
abstract: [structure: see text] Organic extracts of the entomopathogenic fungus Akanthomyces gracilis ARS 2910 contained antibiotics active against Staphylococcus aureus. Bioassay-guided fractionation of the CH2Cl2 extract yielded the antibacterial compound akanthomycin as a mixture of atropisomers along with the closely related compounds 8-methylpyridoxatin and cordypyridone C. Akanthomycin was characterized using X-ray crystallography and NMR.
authors.affiliation: Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853-1301, USA.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Wagenaar
authors.forename: Donna M
authors.initials: DM
authors.lastname: Gibson
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001000:Ants / Q000382:microbiology; D018360:Crystallography, X-Ray; D005658:Fungi / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011728:Pyridones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: C118112:8-methylpyridoxatin; D000900:Anti-Bacterial Agents; D011728:Pyridones; C467065:akanthomycin; C437385:cordypyridone C