[Apoptosis of peripheral blood lymphocytes in patients with chronic viral hepatitis].
The examined 68 patients with chronic viral hepatitis (CVH) demonstrated a high Fas/APO-1 (CD95) expression on the peripheral blood lymphocytes. It correlated with the serum level of the tumor necrosis factor alpha (TNF alpha). The above findings suggest to us the implication of apoptosis in CVH pathogenesis. Following administration of interferonotherapy treatments the number of lymphocytes in the presence of apoptosis has gotten decreased.
Virstiuk
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D000328:Adult; D017209:Apoptosis / Q000502:physiology*; D002908:Chronic Disease; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D019698:Hepatitis C, Chronic / Q000097:blood / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D019701:Hepatitis D, Chronic / Q000097:blood / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D006525:Hepatitis, Viral, Human / Q000097:blood* / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D019014:fas Receptor / Q000097:blood / Q000378:metabolism
D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor; D007372:Interferons