title: The effect of fibrinogen genotype on fibrinogen levels after strenuous physical exercise.
abstract: We have examined the effect of two beta-fibrinogen gene promoter polymorphisms (-455G>A and -854G>A) on the fibrinogen response to severe exercise in a group of male army recruits undergoing basic training. Fibrinogen was measured pre-training and again serially after severe 48 h final military exercise (FME). Out of 884 subjects, 762 completed training of whom 250 were selected for post-FME study. Fibrinogen levels (g/l) were significantly elevated over baseline levels 2, 48 and 96 h after FME, representing increases of 15.7%, 3.4% and 7.6% (p <0.005; p = 0.05 and p <0.005 respectively), with higher levels in -455A allele carriers than genotype -455GG: 3.17+/-0.05 vs. 2.94+/-0.05 (p <0.001), 2.86+/-0.05 vs. 2.60+/-0.05 (p <0.0005) and 2.98+/-0.06 vs. 2.69+/-0.06 (p <0.0005) at 2, 48 and 96 h respectively. There was no effect of the -854G>A polymorphism on fibrinogen, even after taking into account beta-fibrinogen -455 genotype. Thus the fibrinogen -455G>A polymorphism influences fibrinogen levels following exercise. The effect of genotype might be clinically relevant at times of hyperfibrinogenaemia such as following an acute inflammatory response.
authors.affiliation: Department of Medicine, Royal Free and UCL Medical School, UK. d.brull@ucl.ac.uk
authors.forename: D J
authors.initials: DJ
authors.lastname: Brull
authors.forename: S
authors.initials: S
authors.lastname: Dhamrait
authors.forename: R
authors.initials: R
authors.lastname: Moulding
authors.forename: A
authors.initials: A
authors.lastname: Rumley
authors.forename: G D O
authors.initials: GD
authors.lastname: Lowe
authors.forename: M J
authors.initials: MJ
authors.lastname: World
authors.forename: S E
authors.initials: SE
authors.lastname: Humphries
authors.forename: H E
authors.initials: HE
authors.lastname: Montgomery
mesh_terms: D000210:Acute-Phase Reaction; D000328:Adult; D015331:Cohort Studies; D015444:Exercise / Q000502:physiology*; D005340:Fibrinogen / Q000032:analysis* / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008889:Military Personnel; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D021122:Protein Subunits
chemical_list: D021122:Protein Subunits; D005340:Fibrinogen