The role of HSV in the transmission and progression of HIV.
Herpes simplex virus (HSV) is a common co-infection in persons infected with human immunodeficiency virus type 1 (HIV-1). Chronic perianal ulceration from herpes simplex virus type 2 (HSV-2) was one of the first opportunisitc infections identified among patients with AIDS. Subsequent research has established that the natural history of HSV-2 is altered in co-infected persons as they experience more frequent clinical and subclinical reactivation of HSV than persons infected only with HSV-2. In addition, there are accumulating data to suggest a significant biological interaction between these two viruses that result in more efficient sexual transmission of HIV-1 and an increased rate of HIV replication during both clinical and subclinical HSV reactivation.
Schacker
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Department of Medicine, University of Minnesota, Division of Infectious Diseases, Box 250, 516 Delaware Street, Minneapolis, MN 55055, USA. schacker@mail.ahc.umn.edu
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000503:physiopathology*; D018450:Disease Progression; D015658:HIV Infections / Q000453:epidemiology / Q000503:physiopathology* / Q000635:transmission*; D015497:HIV-1; D006558:Herpes Genitalis / Q000503:physiopathology*; D018259:Herpesvirus 1, Human / Q000472:pathogenicity*; D018258:Herpesvirus 2, Human / Q000472:pathogenicity*; D006801:Humans