title: Use of particulate dentin-plaster of Paris combination with/without platelet-rich plasma in the treatment of bone defects around implants.
abstract: OBJECTIVE
  To evaluate the effect of particulate dentin-plaster of Paris with and without platelet-rich plasma (PRP) on bone healing and new bone formation around titanium dental implants in a canine model. Histologic sections and histomorphometric analysis of the defects were obtained at 6 and 12 weeks after surgery.
  
  
  METHODS
  Three circular bone defects were surgically prepared in iliac crest sites in each of 10 animals. A total of 30 Avana dental implants were placed in the animals. They were self-tapping, screw-type implants, 10 mm in length and 4 mm in diameter, all made of commercially pure titanium. A titanium implant was placed centrally in each defect. In each dog, the defects were treated with 1 of the following 3 treatment modalities: (1) no treatment (control); (2) grafting with particulate dentin-plaster of Paris; (3) grafting with particulate dentin-plaster of Paris and PRP.
  
  
  RESULTS
  Histologic analysis showed that all of the bone defects surrounding the implants that were treated with particulate dentin-plaster of Paris, with and without PRP, were filled with new bone. The defects that were not treated (control) demonstrated new bone formation only in the inferior threaded portion of the implants.
  
  
  CONCLUSIONS
  Histomorphometric results revealed a higher percentage of bone contact with particulate dentin-plaster of Paris and PRP compared to the control and particulate dentin-plaster of Paris.
  
  
  CONCLUSIONS
  These results suggested that bone defects around titanium implants can be treated successfully with particulate dentin-plaster of Paris, and that the outcome can be improved if PRP is also used.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Oral Biology Research Institute, College of Dentistry, Chosun University, GwangJu City, Korea. SGKIM@mail.chosun.ac.kr
authors.forename: Su-Gwan
authors.initials: SG
authors.lastname: Kim
authors.forename: Chae-Heon
authors.initials: CH
authors.lastname: Chung
authors.forename: Young-Kyun
authors.initials: YK
authors.lastname: Kim
authors.forename: Joo-Cheol
authors.initials: JC
authors.lastname: Park
authors.forename: Sung-Chul
authors.initials: SC
authors.lastname: Lim
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D002133:Calcium Sulfate / Q000494:pharmacology / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous / Q000009:adverse effects; D015921:Dental Implants / Q000009:adverse effects; D003764:Dental Materials / Q000494:pharmacology / Q000627:therapeutic use*; D003804:Dentin / Q000637:transplantation*; D004285:Dogs; D005260:Female; D007085:Ilium / Q000601:surgery; D020007:Implants, Experimental / Q000009:adverse effects; D008297:Male; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology; D017713:Platelet Transfusion; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use; D018709:Statistics, Nonparametric
chemical_list: D015921:Dental Implants; D003764:Dental Materials; D010982:Platelet-Derived Growth Factor; D002133:Calcium Sulfate