[An genetic epidemiology study of MTHFR gene and blood level (sibpair linkage analysis)].
OBJECTIVE
To explore the relationship between MTHFR gene and blood pressure.


METHODS
A total of 142 sibpairs were collected from rural communities of CCPACH. MTHFR gene genotypes were determined by an assay based on the polymerase chain reaction. Phenotype of this study was the level of blood pressure. Covariates were measured by questionnaire, physical examination and clinical indices. Sibpair linkage analysis was used to analyse data by SAGE software.


RESULTS
In this study, prevalence of TT genotype of MTHFR gene was 9.3%, while CT was 41%. There was no evidence for linkage of the MTHFR gene with either systolic or diastolic blood pressure identified.


CONCLUSIONS
In our study population, MTHFR gene did not seem to be not related to blood pressure.
Wang
T
T
Department of Epidemiology, Beijing Medical University, Beijing 100083, China.
Hu
Y
Y
Li
L
L
Zhan
S
S
Gao
Y
Y
Cao
W
W
Wu
T
T
Li
X
X
Guo
X
X
D000328:Adult; D001794:Blood Pressure / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D016014:Linear Models; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D008957:Models, Genetic; D017720:Molecular Epidemiology; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence
D005819:Genetic Markers; D042965:Methylenetetrahydrofolate Reductase (NADPH2)