[The combination of cyclosporin A and androgen in the treatment of chronic aplastic anemia].
OBJECTIVE
To explore the therapeutic effectiveness of combination of cyclosporin A (CsA) and androgen in the treatment of chronic aplastic anemia (CAA).


METHODS
Androgen alone or combined with CsA for the treatment of CAA was compared by a randomized controlled clinical trial.


RESULTS
The efficacy of androgen combined with CsA (87.9%) was higher than that of androgen alone (57.1%). Therapeutic effectiveness of the combination treatment between the patients with positive and negative peripheral blood mononuclear cells (PBMNCs) inhibiting normal colony formation unit-granulocyte and macrophage (CFU-GM) test showed a significant difference (P < 0.005).


CONCLUSIONS
Androgen combined with CsA had a much better efficacy than that of androgen alone in the treatment of CAA. The patients' PBMNCs inhibiting normal CFU-GM growth test can be used as an index of the treatment outcome. The side effects of the combination therapy are low and tolerable.
Zhou
Y
Y
Department of Hematology, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310006, China.
Yu
R
R
Shen
Y
Y
Zhu
N
N
Lin
S
S
Luo
X
X
Gao
R
R
Jin
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000728:Androgens / Q000627:therapeutic use*; D000741:Anemia, Aplastic / Q000097:blood / Q000188:drug therapy*; D001772:Blood Cell Count; D002648:Child; D002908:Chronic Disease; D016572:Cyclosporine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
D000728:Androgens; D016572:Cyclosporine