title: Primary squamous cell carcinoma of the liver producing parathyroid hormone-related protein.
abstract: We report here an autopsy case of primary squamous cell carcinoma of the liver in a 63-year-old man who had hypercalcemia and an elevated serum level of parathyroid hormone-related protein. At autopsy, primary squamous cell carcinoma of the liver was found, without distinct preceding or associated hepatic or biliary diseases; no extrahepatic primary focus of squamous cell carcinoma was found. Bone involvement was not demonstrated, either radiologically or pathologically. Immunohistochemically, parathyroid hormone-related protein was detectable in the squamous cell carcinoma cells and it may have been responsible for the hypercalcemia. Such a case has not been reported so far in the English-language or the Japanese literature.
authors.affiliation: Second Department of Pathology, Kanazawa University School of Medicine, Japan.
authors.forename: Takahito
authors.initials: T
authors.lastname: Saito
authors.forename: Kenichi
authors.initials: K
authors.lastname: Harada
authors.forename: Koichi
authors.initials: K
authors.lastname: Tsuneyama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hirano
authors.forename: Susumu
authors.initials: S
authors.lastname: Amaya
authors.forename: Motoko
authors.initials: M
authors.lastname: Sasaki
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kaneko
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Yasuni
authors.initials: Y
authors.lastname: Nakanuma
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000175:diagnosis; D017809:Fatal Outcome; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000097:blood* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism*
chemical_list: C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins