Immunobiology and privilege of neuronal retina and pigment epithelium transplants.
Despite the existence of ocular immune privilege, immune rejection may be a barrier to successful retinal transplantation. We have examined in mice the extent to which the subretinal space (SRS) is an immune privileged site, and whether retinal pigment epithelium and neuronal retinal tissue have properties of immune privileged tissues. We report that (1) The SRS is an immune privileged site; (2) Neonatal RPE is an immune privileged tissue; (3) Neuronal retina is a partially immune privileged tissue; and (4) Microglia within neonatal neural retina grafts promote photoreceptor differentiation, become activated, and induce sensitization of the recipient and serve as targets of immune rejection.
Streilein
J Wayne
JW
Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA. waynes@vision.eri.harvard.edu
Ma
Naili
N
Wenkel
Hartmut
H
Ng
Tat Fong
TF
Zamiri
Parisa
P
D000818:Animals; D000831:Animals, Newborn; D000867:Anterior Chamber / Q000276:immunology*; D006084:Graft Rejection; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D051379:Mice; D008815:Mice, Inbred Strains; D017628:Microglia / Q000276:immunology*; D010857:Pigment Epithelium of Eye / Q000276:immunology / Q000637:transplantation*; D012160:Retina / Q000276:immunology / Q000637:transplantation*; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II