title: Clinical effect of a new liquid dentifrice containing triclosan/copolymer on existing plaque and gingivitis.
abstract: BACKGROUND
  Dentifrices traditionally have been formulated as pastes or gels. However, liquid varieties recently have become available The authors conducted a study to determine whether a fluoridated liquid product with added triclosan and a polyvinyl methyl ether/maleic acid, or PVM/MA, copolymer delivery system is efficacious for the control of supragingival plaque and gingivitis.
  
  
  METHODS
  The authors conducted a six-month, double-blind, parallel, stratified clinical study in accordance with American Dental Association guidelines for the clinical evaluation of antiplaque/antigingivitis products. Subjects who qualified with a suitable amount of existing plaque and gingivitis were given one of two dentifrices: an "experimental" liquid dentifrice containing 0.3 percent triclosan, 2.0 percent PVM/MA copolymer and 0.243 percent sodium fluoride, or NaF, in a silica base; or a "placebo" dentifrice containing 0.243 percent NaF in a silica base. The authors collected subjects' plaque and gingival index scores at baseline, three months and six months.
  
  
  RESULTS
  The results of the study indicate that the use of the experimental liquid dentifrice provided a significant reduction in existing levels of plaque and gingivitis as compared with the placebo standard dentifrice. At six months, the experimental group demonstrated a 34.9 percent reduction in plaque formation and a 25.7 percent reduction in gingivitis as compared with the placebo group (P < .001).
  
  
  CONCLUSIONS
  When compared with the placebo, the experimental dentifrice had a significantly better ability to reduce plaque and gingivitis. When compared with results reported in the literature, this new form of dentifrice achieved results comparable in efficacy to those of traditional dentifrice pastes with matching active ingredients.
  
  
  CONCLUSIONS
  This study confirms that a liquid dentifrice containing a triclosan/copolymer/NaF delivery system is efficacious in its ability to reduce existing plaque and gingivitis.
authors.affiliation: Department of Oral Pathology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
authors.forename: Terdphong
authors.initials: T
authors.lastname: Triratana
authors.forename: Kedar N
authors.initials: KN
authors.lastname: Rustogi
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Volpe
authors.forename: William
authors.initials: W
authors.lastname: DeVizio
authors.forename: Margaret
authors.initials: M
authors.lastname: Petrone
authors.forename: Martin
authors.initials: M
authors.lastname: Giniger
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D003773:Dental Plaque / Q000145:classification / Q000517:prevention & control*; D003774:Dental Plaque Index; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005891:Gingivitis / Q000145:classification / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008298:Maleates; D008875:Middle Aged; D009824:Ointments; D010512:Periodontal Index; D014677:Pharmaceutical Vehicles; D010919:Placebos; D011095:Polyethylenes; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use; D012996:Solutions; D018709:Statistics, Nonparametric; D014260:Triclosan / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D003692:Delayed-Action Preparations; D003802:Dentifrices; D008298:Maleates; D009824:Ointments; D014677:Pharmaceutical Vehicles; D010919:Placebos; D011095:Polyethylenes; D012996:Solutions; D014260:Triclosan; D012969:Sodium Fluoride; C043105:poly(methyl vinyl ether-co-maleic anhydride)