Acute lymphoblastic leukemia accompanied by chromosomal abnormality of translocation (12;17).
This report concerns a female patient with B-precursor acute lymphoblastic leukemia with concomitant expression of CD13 and CD33. A rare chromosomal abnormality, t(2;17)(p13:q21), was detected in 70% of metaphases analyzed. A new subgroup of acute leukemia is proposed, consisting of our case and 12 reported cases with similar chromosomal abnormalities. This subgroup has a poor prognosis and a high incidence of biphenotypic characteristics.
Asahara
S I
SI
Department of Internal Medicine, Kakogawa Municipal Hospital, Hyogo, Japan.
Saigo
K
K
Hasuike
N
N
Tamura
M
M
Maeda
Y
Y
Tomofuji
Y
Y
Chinzei
T
T
Tatsumi
E
E
D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D018826:CD13 Antigens / Q000032:analysis; D002881:Chromosomes, Human, Pair 12; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D008875:Middle Aged; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000235:genetics / Q000276:immunology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000235:genetics* / Q000276:immunology; D011379:Prognosis; D063268:Sialic Acid Binding Ig-like Lectin 3; D014178:Translocation, Genetic
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C571163:CD33 protein, human; D063268:Sialic Acid Binding Ig-like Lectin 3; D018826:CD13 Antigens