[Relationship between changes of phospholipid and lipid peroxide of erythrocyte membrane and diabetic retinopathy].
OBJECTIVE
To study the relation between the changes of phospholipid and lipid peroxide (LPD) in erythrocyte membrane in diabetes mellitus with the occurrence of diabetic retinopathy (DR).


METHODS
The levels of triglyceride (TG), cholesterol (TC), glycosylated hemoglobin (HbA(1)c), phosphatidylethanolamine (PE), phosphatidylinostiol (PI), phosphatidylserine (PS), phosphatidylcholine (PC), sphingomyelin (SM), lysophosphatidylcholine (LPC), lipid peroxide (LPO) and the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were investigated in 44 diabetic patients with DR, 20 diabetic patients with no DR (NDR) and 30 sex and age matched normal control subjects.


RESULTS
A significant decrease in PE, PI, PS, PC, SM, SOD and GSH-PX and a significant increase in LPC, LPO, TG, TC and HbA(1)c were detected in DR and NDR group when compared with the normal controls. These changes were more obvious in DR group.


CONCLUSIONS
The lipid peroxidation and the alteration of the erythrocyte membrane phospholipid compositions may contribute to the occurrence and development of DR.
He
J
J
Department of Ophthalmology, The Affiliated Hospital of Qingdao Medical College. Qingdao 266003.
Qiu
Y
Y
Yan
Y
Y
Niu
Y
Y
D000328:Adult; D000368:Aged; D003930:Diabetic Retinopathy / Q000097:blood / Q000209:etiology*; D004910:Erythrocyte Membrane / Q000737:chemistry*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood*
D006442:Glycated Hemoglobin; D008054:Lipid Peroxides; D010743:Phospholipids