Quantitative foetal fibronectin as a predictor of successful induction of labour in post-date pregnancies.
OBJECTIVE
To study the relationship between induced labour, quantitative levels of fibronectin and the Bishop score.


METHODS
Vaginal fibronectin/Bishop score were estimated in 33 nulliparous women undergoing induction of labour for post-dates at the Department of Obstetrics and Gynaecology, Guy's and St. Thomas' Hospital London.


RESULTS
There was no significant relationship between either the fibronectin level or Bishop score and the duration of the latent phase (R(2)=0.001; P=0.86 and R(2)=0.12; P=0.08, respectively). There was no relationship between the total prostaglandin dose and fibronectin level (R(2)=0.03; P=0.39) nor any significant correlation between either the Bishop score or fibronectin level and the induction to delivery time (R(2)=0.13; P=0.11 and R(2)=0.0006; P=0.97, respectively). Significant relationships were observed inversely between the total prostin dose and Bishop score (R(2)=0.33; P=0.002), between the total prostin dose and latent phase (R(2)=0.54; P=0.000009) and between Bishop score and the fibronectin levels (R(2)=0.19; P<0.01).


CONCLUSIONS
Quantitative foetal fibronectin is not a useful test for inducibility at term.
Ojutiku
Dale
D
Department of Obstetrics & Gynaecology, St. Thomas' Hospital London, UK.
Jones
Griff
G
Bewley
Susan
S
D000293:Adolescent; D000328:Adult; D000527:Alprostadil / Q000627:therapeutic use; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005353:Fibronectins / Q000032:analysis*; D006801:Humans; D007751:Labor, Induced; D011237:Predictive Value of Tests; D011247:Pregnancy; D011273:Pregnancy, Prolonged / Q000502:physiology*; D014665:Vasodilator Agents / Q000627:therapeutic use
D005353:Fibronectins; D014665:Vasodilator Agents; D000527:Alprostadil