[Fisher discriminant analysis for carcinogenic potency of aromatic amines].
OBJECTIVE
To study the relationship between carcinogenicity and their structure and physicochemical parameters of aromatic amines.


METHODS
Fisher discriminant analysis for carcinogenicity of aromatic amines in two different batches was conducted with estimation of parameters of physicochemical using central atom and functional groups in combination with structural parameters of polycyclic aromatic hydrocarbons (PAHs).


RESULTS
The discriminant efficacy approximated to that of the two in a series of equations (I and III) established by Yuta, but inferior to the optimal equation II.


CONCLUSIONS
The selected physicochemical parameters can be applied to QSAR study on carcinogenicity of most aromatic amines, with better results in Fisher discriminant analysis.
Zhu
Y
Y
Department of Pathophysiology, Zhejiang Medical University, Hangzhou 310031.
Yu
Y
Y
Chen
X
X
D000588:Amines / Q000633:toxicity*; D000818:Animals; D015197:Carcinogenicity Tests; D016002:Discriminant Analysis; D021281:Quantitative Structure-Activity Relationship
D000588:Amines