title: Prognostic value of p53, c-erb-B2 and MIB-1 in endometrial carcinoma.
abstract: OBJECTIVE
  To assess the immunohistochemical expression of p53 protein, a tumour suppressor gene of the oncogene c-erb-B2 and MIB-1 proliferation marker (Ki-67 antigen) in endometrial carcinoma.
  
  
  METHODS
  We studied 29 cases of endometrial carcinoma in which the p53, c-erb-B2 and MIB-1/Ki-67 antigens were investigated by an immunohistochemical method. We evaluated the correlations among the immunohistochemical positivity and the grading, depth of myometrial invasion, stage of the neoplasia and follow-up.
  
  
  RESULTS
  Both p53 and c-erb-B2 were positive in 16 out of 29 cases (55.2%), whereas MIB-1 was positive in 19 out of 29 cases (65.5%). All these three antigens showed a positive correlation with the grading, myometrial invasion and FIGO stage. Regarding follow-up, p53, c-erb-B2 and MIB-1 were, respectively, positive in 100%, 83.4% and 66.7% of neoplasias of patients who died of disease whereas they were positive in 40%, 40% and 60%, respectively, of tumours of patients with no evidence of disease.
  
  
  CONCLUSIONS
  The overexpression of p53, c-erb-B2 and MIB-1 seem to indicate a more malignant tumour phenotype.
authors.affiliation: Department of Pharmacology, Gynaecology and Obstetrics, University of Sassari, Italy.
authors.forename: P L
authors.initials: PL
authors.lastname: Cherchi
authors.forename: V
authors.initials: V
authors.lastname: Marras
authors.forename: G
authors.initials: G
authors.lastname: Capobianco
authors.forename: G
authors.initials: G
authors.lastname: Ambrosini
authors.forename: M D
authors.initials: MD
authors.lastname: Piga
authors.forename: G M
authors.initials: GM
authors.lastname: Fadda
authors.forename: N
authors.initials: N
authors.lastname: Rosas
authors.forename: S
authors.initials: S
authors.lastname: Dessole
mesh_terms: D034961:Antigens, Nuclear; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D034961:Antigens, Nuclear; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53