title: Functional peculiarities of MAP2 in DBA/2J inbred mice as a component of genetic predisposition to seizures.
abstract: We compared the content of high molecular microtubule-associated protein-2 and its phosphorylation by cAMP- and Ca(2+)/calmodulin-dependent protein kinases in the brain of DBA/2J and C57Bl/6 inbred mice. The revealed differences in protein content and phosphorylation can be attributed to the mechanisms mediating audiogenic seizures in DBA/2J mice and to differential sensitivity of these inbred lines to seizure-inducing factors.
authors.affiliation: Group of the Mechanisms of Synaptic Transmission, Institute of Theoretical and Experimental Biophysics, Pushchino. neurochem@mail.ru
authors.forename: T A
authors.initials: TA
authors.lastname: Chulanova
authors.forename: S N
authors.initials: SN
authors.lastname: Echikov
authors.forename: V B
authors.initials: VB
authors.lastname: Sadovnikov
authors.forename: T G
authors.initials: TG
authors.lastname: Shchipakina
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000201:enzymology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006624:Hippocampus / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D010766:Phosphorylation; D012640:Seizures / Q000235:genetics*; D013696:Temperature; D013997:Time Factors
chemical_list: D008869:Microtubule-Associated Proteins; D017868:Cyclic AMP-Dependent Protein Kinases