BAL 9141, a new broad-spectrum pyrrolidinone cephalosporin: activity against clinically significant anaerobes in comparison with 10 other antimicrobials.
The in vitro potency of BAL 9141, a new pyrrolidinone cephalosporin, was tested against non-duplicate strains of anaerobic bacteria. The MIC(50) was 1 mg/L against Actinomyces species, Clostridium species, Gram-positive anaerobic cocci, Porphyromonas species, Fusobacterium species, Lactobacillus species, Prevotella species and Veillonella species. The MIC(50) was 16 mg/L for Bacteroides fragilis and other Bacteroides species. BAL 9141 was not active against cefoxitin-resistant Bacteroides fragilis.
Wootton
M
M
Bristol Centre for Antimicrobial Research and Evaluation, North Bristol NHS Trust/University of Bristol, Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK.
Bowker
K E
KE
Holt
H A
HA
MacGowan
A P
AP
D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000302:isolation & purification; D002511:Cephalosporins / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D007769:Lactams / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology*; D013845:Thienamycins / Q000494:pharmacology*
D002511:Cephalosporins; D007769:Lactams; D010406:Penicillins; D013845:Thienamycins; C443755:ceftobiprole