title: Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata.
abstract: A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC(50) values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) microg/mL (microM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.
authors.affiliation: Program for Collaborative Research in Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, USA.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhuting
authors.initials: Z
authors.lastname: Fan
authors.forename: Ghee T
authors.initials: GT
authors.lastname: Tan
authors.forename: Hee-Byung
authors.initials: HB
authors.lastname: Chai
authors.forename: John M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: Handong
authors.initials: H
authors.lastname: Sun
authors.forename: Harry H S
authors.initials: HH
authors.lastname: Fong
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D019686:Lamiaceae / Q000737:chemistry*; D008175:Lung Neoplasms; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012516:Osteosarcoma; D010051:Ovarian Neoplasms; D010946:Plants, Medicinal / Q000737:chemistry*; D011471:Prostatic Neoplasms; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C452213:pseudoirroratin A