Exacerbation of Avellino corneal dystrophy after laser in situ keratomileusis.
OBJECTIVE
To report a case of Avellino corneal dystrophy that increased in severity 1 year after uncomplicated laser in situ keratomileusis (LASIK) for myopia.


METHODS
Avellino dystrophy was confirmed by polymerase chain reaction sequencing of DNA from the patient and her parents.


RESULTS
Best spectacle-corrected visual acuity decreased from 20/20 to 20/30 12 to 20 months after LASIK owing to opacities that appeared centrally in the corneal stroma and the LASIK flap and remaining posterior stroma interface.


CONCLUSIONS
LASIK is contraindicated in patients with Avellino corneal dystrophy because vision may be reduced by corneal opacities that appear in the interface of the flap and remaining posterior stroma postoperatively.
Wan
Xiu Hua
XH
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Brain Korea 21 Project for Med Science, CPO Box 8044, Seoul 120-752, Korea.
Lee
Hyun Chae
HC
Stulting
R Doyle
RD
Kim
Terry
T
Jung
Seung Eun
SE
Kim
Moon Jung
MJ
Kim
Eung Kweon
EK
D000328:Adult; D000075202:Contraindications; D003317:Corneal Dystrophies, Hereditary / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D003318:Corneal Opacity / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D004252:DNA Mutational Analysis; D018450:Disease Progression; D016326:Extracellular Matrix Proteins; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D009216:Myopia / Q000601:surgery; D009363:Neoplasm Proteins / Q000235:genetics; D016133:Polymerase Chain Reaction; D016212:Transforming Growth Factor beta / Q000235:genetics; D014786:Vision Disorders / Q000209:etiology / Q000503:physiopathology; D014792:Visual Acuity; D000099222:betaIG-H3 Protein
D016326:Extracellular Matrix Proteins; D009363:Neoplasm Proteins; D016212:Transforming Growth Factor beta; D000099222:betaIG-H3 Protein