[Umbilical cord blood stem cells transplantation from an unrelated donor into an adult with severe aplastic anemia].
OBJECTIVE
To evaluate the availability of the treatment of adult severe aplastic anemia with unrelated allo-cord blood stem cell transplantation (CBSCT).


METHODS
HLA-matched unrelated cord blood transplantation has been successfully performed for an adult severe aplastic anemia patient. A unit of cord blood provided by Guangzhou Cord Blood Bank containing 1.89 x 10(7)/kg mononucleated cells, 1.8 x 10(4)/kg CFU-GM and of CD(34) positive cells was 0.009. The patient was conditioned with CTX (60 mg/kg) and anti-lymphocyte globulin (ALG, 120 mg/kg). GVHD prophylaxis consisted of both MTX and CsA. The CsA had been given for 8 months.


RESULTS
The lowest ANC was 0.6 x 10(9)/L post-transplantation. The patient achieved an ANC of greater than 0.5 x 10(9)/L at 10 days, and the platelet of greater than 50.0 x 10(9)/L at day 20 after transplantation. He developed Grade 1 GVHD in the tenth month after grafting. Microsatellite DNA fingerprinting indicated a stable donor-recipient mixed chimerism, whilst the circulating red cells remained host origin.


CONCLUSIONS
It is the first report in China on successful treatment of adult severe aplastic anemia by unrelated allo-CBSCT.
Mao
P
P
First Municipal Peoples Hospital of Guangzhou, Guangzhou 510180, China.
Liao
C
C
Zhu
Z
Z
Wang
H
H
Wang
S
S
Mo
W
W
Ying
Y
Y
Li
Q
Q
Liu
B
B
D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood / Q000628:therapy*; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects; D016172:DNA Fingerprinting; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism; D006086:Graft vs Host Disease / Q000209:etiology / Q000235:genetics; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D013997:Time Factors; D018183:Transplantation Chimera / Q000235:genetics; D014184:Transplantation, Homologous; D016896:Treatment Outcome