title: Effect of exercise on stability of chronically enlarged motor units.
abstract: Chronic denervation syndromes such as the post-polio syndrome are associated with progressive muscle weakness and fatigue after motoneuron death. Neither the etiology nor the management of these syndromes is clear. To address this issue, we partially denervated rat hindlimb muscles for 1 or 12 months and examined whether chronically enlarged motor units (MUs) become destabilized with time and further destabilized by daily running on exercise wheels. MU enlargement, measured electrophysiologically and morphologically was significantly reduced at 12 months in extensively denervated muscles, and to a lesser extent in moderately denervated muscles, as compared to the findings at 1 month. A 1-month period of running exercise further reduced the size of the chronically enlarged MUs in the extensively denervated muscles. We have therefore (1) successfully established a rat model of time-related MU size reduction, in which destabilization of chronically enlarged MUs results in loss of axonal terminals, and (2) demonstrated that nonphysiological activity has small but significant effects of further destabilizing the chronically enlarged MUs.
authors.affiliation: Department of Pharmacology, Division of Neuroscience, Faculty of Medicine, University of Alberta, 525 Heritage Medical Research Center, Edmonton, Alberta T6G 2S2 Canada.
authors.forename: Siu Lin
authors.initials: SL
authors.lastname: Tam
authors.forename: Vey
authors.initials: V
authors.lastname: Archibald
authors.forename: Neil
authors.initials: N
authors.lastname: Tyreman
authors.forename: T
authors.initials: T
authors.lastname: Gordon
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D005260:Female; D009043:Motor Activity; D009045:Motor Endplate / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology*; D009121:Muscle Denervation; D018482:Muscle, Skeletal / Q000166:cytology / Q000294:innervation / Q000502:physiology*; D020966:Muscular Disorders, Atrophic / Q000473:pathology / Q000503:physiopathology*; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley