Anti-inflammatory compounds from the bitter mushroom, Sarcodon scabrosus.
A bioassay-guided purification procedure from the methanol extract of Sarcodon scabrosus led to the isolation of several anti-inflammatory compounds: sarcodonin A (1) and G (2), and related compounds (3, 4 and 5). We named these related compounds neosarcodonin A (3), B (4) and C (5) and elucidated their structures on the basis of spectral data. Topical application of each of these compounds to mouse ears suppressed TPA-induced inflammation. Neosarcodonin C (5) exhibited the highest activity and inhibited the TPA-induced edema on mouse ears by up to 87% with a 200-microg application.
Hirota
Mitsuru
M
Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, Kami-ina, Nagano, Japan. hirotam@gipmc.shinshu-u.ac.jp
Morimura
Keiji
K
Shibata
Hisao
H
D000363:Agaricales; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; C410409:sarcodonin G