IMGT gene identification and Colliers de Perles of human immunoglobulins with known 3D structures.
A new database, IMGT/3Dstructure-DB, was developed and implemented in the IMGT (international ImMunoGeneTics database) information system (http://imgt.cines.fr) to provide a unique expertised resource on immunoglobulin and T-cell receptor structural data. Corresponding protein sequences were annotated with IMGT tools, which allow the precise identification of the genes expressed in these proteins, and the description of framework and complementarity determining regions according to the IMGT standardized nomenclature and IMGT unique numbering. Two-dimensional graphical representations of the V-DOMAINs, designated as Colliers de Perles, are automatically produced. A query Web interface allows interactive search of the IMGT/3D structure-DB data. In this article, IMGT gene identification and Colliers de Perles of human immunoglobulins with known 3D structures in the Protein Data Bank are presented.
Ruiz
Manuel
M
Laboratoire d'ImmunoGénétique Moléculaire (LIGM), Université Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France.
Lefranc
Marie-Paule
MP
D000483:Alleles; D000595:Amino Acid Sequence; D030561:Databases, Nucleic Acid; D030562:Databases, Protein; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry* / Q000145:classification / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D009626:Terminology as Topic; D014961:X-Ray Diffraction
D007136:Immunoglobulins