title: Synthesis of 1,4-disubstituted 2-methylpiperazine derivatives, new 5-HT(1A) receptor ligands.
abstract: Preparation of some new 1,4-substituted 2-methylpiperazine derivatives is reported. The influence of structural modifications on their affinity to 5-HT(1A) receptors is discussed. Compounds were synthesised by the reaction of 2-methylpiperazine with 2-chloropyrimidine or 2-chloroquinoline followed by condensation with 1,4 dibromobutane. The resulting quaternary ammonium salts after the reaction with an imide gave the respective final products.
authors.affiliation: Pharmaceutical Research Institute, Warsaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Cybulski
authors.forename: W
authors.initials: W
authors.lastname: Dankiewicz
authors.forename: Z
authors.initials: Z
authors.lastname: Chilmończyk
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism; D066298:In Vitro Techniques; D008024:Ligands; D010879:Piperazines / Q000138:chemical synthesis* / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism*; D044263:Receptors, Serotonin, 5-HT1; D018490:Serotonin Agents / Q000138:chemical synthesis* / Q000378:metabolism
chemical_list: D008024:Ligands; D010879:Piperazines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D018490:Serotonin Agents