title: [Apoptosis in age-related macular degeneration].
abstract: OBJECTIVE
  To examine the role of apoptosis in photoreceptor cell death in age-related macular degeneration.
  
  
  METHODS
  16 human eyes with age-related macular degeneration (ARMD) were studied by histopathology and TDT-mediated biotin-dUTP nick-end labeling (TUNEL) technique.
  
  
  RESULTS
  The characteristic DNA fragmentation of apoptosis was observed in scattered photoreceptor cells in 6 of 16 eyes.
  
  
  CONCLUSIONS
  It is suggested that apoptosis be one of the important pathways of photoreceptor cell death in age-related macular degeneration.
authors.affiliation: Eye & ENT Hospital, Shanghai Medical University, Shanghai 200031.
authors.forename: G
authors.initials: G
authors.lastname: Xu
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: A
authors.initials: A
authors.lastname: Tso
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D005260:Female; D006801:Humans; D020287:In Situ Nick-End Labeling; D008268:Macular Degeneration / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010786:Photoreceptor Cells / Q000473:pathology*