Adverse reproduction outcomes among employees working in biomedical research laboratories.
OBJECTIVE
The aim of the study was to investigate reproductive outcomes such as birthweight, preterm births, and postterrm births among women working in research laboratories while pregnant.


METHODS
Female university personnel were identified from a source cohort of Swedish laboratory employees, and the database was linked to the medical birth register. The first births of the women were included in the analysis, 249 pregnancies among the women with laboratory work and 613 pregnancies among the women without laboratory tasks. Information about exposure to various laboratory agents was obtained from a previous questionnaire investigation at the research group level according to a specific definition. The ponderal index and ratio between observed and expected birthweights were calculated. Logistic regression models were used for analyses of dichotomous outcomes (preterm, postterrm and birthweight).


RESULTS
Exposure to laboratory work with solvents was associated with an increased risk of preterm births, the estimated odds ratio (OR) being 3.4 (1.0 < 95% confidence interval < 11.9). An association with work with bacteria was also observed for postterm births (OR 2.7, 1.0 < or = 95% confidence interval < 7.4).


CONCLUSIONS
There was a slightly elevated risk for some reproductive outcomes among the women working with certain laboratory tasks, specifically for preterm and postterm births in relation to work with solvents and bacteria.
Wennborg
Helena
H
Department of Biosciences, Novum Research Park, Karolinska Institutet, Huddinge, Sweden. helena.wennborg@biosci.ki.se
Bonde
Jens Peter
JP
Stenbeck
Magnus
M
Olsen
Jørn
J
D001724:Birth Weight; D016022:Case-Control Studies; D015331:Cohort Studies; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D007226:Infant Mortality / Q000639:trends*; D007231:Infant, Newborn; D007234:Infant, Premature; D016015:Logistic Models; D018811:Maternal Exposure / Q000009:adverse effects*; D017056:Medical Laboratory Personnel / Q000706:statistics & numerical data*; D007752:Obstetric Labor, Premature / Q000453:epidemiology* / Q000209:etiology; D016273:Occupational Exposure / Q000009:adverse effects*; D016272:Occupational Health; D011247:Pregnancy; D012016:Reference Values; D012106:Research; D018570:Risk Assessment; D013548:Sweden / Q000453:epidemiology