[Study on clinical and laboratory features of preleukemia patients].
OBJECTIVE
To explore prospective diagnostic criteria for preleukemia.


METHODS
A case control study of the discrepancies of clinical and laboratory features between patients with preleukemia and those with chronic aplastic anemia (CAA) or atypical paroxysmal nocturnal hemoglubinuria (a-PNH).


RESULTS
There were eight variables of significance: (1) lymphocytoid micromegakaryocytes in marrow; (2) immature granulocytes in peripheral blood; (3) >or= 2% myeloblasts in marrow; (4) positive periodic acid schiff (PAS) staining of nucleated erythrocytes; (5) myeloid differentiation index >or= 1.8; (6) clonal karyotypic abnormalities; (7) negative sister chromatid differentiation; (8) > 4.0 cluster/colony ratio of granulocyte-macrophage colony-forming units (CFU-GM). The following criteria was assigned: A: To meet (1) and at least two of the other seven variables; B: To meet at least four of the eight variables. All of the patients with preleukemia met A or B and none of the patients with CAA or a-PNH did.


CONCLUSIONS
Preleukemia is different from CAA or a-PNH. It has its own clinical and laboratory features, which may be useful for prospective diagnosis.
Shao
Z
Z
Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China.
Shi
J
J
Chen
G
G
Li
K
K
Liu
H
H
Zhang
Y
Y
Zheng
Y
Y
He
H
H
Zhao
M
M
He
G
G
Zhang
H
H
Chu
Y
Y
Hao
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D017209:Apoptosis; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D011289:Preleukemia / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D012189:Retrospective Studies