[Efficiency of immunocorrection using cytokines in the therapy of papillomavirus infection].
The data of the immunological examination and the results of treatment of 86 patients with papillomavirus infection (PVI) are presented. The multifactor suppression of cell-mediated and humoral immunity was established. The degree of immune disturbances correlated with the spread and severity of lesions. The use of systemic injections of cytokines (leukinferon and concentrated interferon) in low doses as adjuvant therapy with laser-radiosurgery led to the normalization of most immunological characteristics and the course of PVI without relapses.
Dubenskiĭ
V V
VV
State Medical Academy, Tver, Russia.
Kuznetsov
V P
VP
Beliaev
D L
DL
Sliusar'
N N
NN
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D007136:Immunoglobulins / Q000032:analysis; D016130:Immunophenotyping; D007370:Interferon Type I / Q000008:administration & dosage*; D008297:Male; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000188:drug therapy / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014412:Tumor Virus Infections / Q000188:drug therapy / Q000276:immunology*
D000276:Adjuvants, Immunologic; D016207:Cytokines; D004338:Drug Combinations; D007136:Immunoglobulins; D007370:Interferon Type I; C062252:leukinferon