title: The whole story: treatment outcomes with Symbicort.
abstract: Asthma is a chronic inflammatory disorder of the airways that has a considerable socioeconomic impact. Asthma management guidelines have been introduced to help provide better long-term control of asthma. Although recommended guidelines may increase the direct medication costs, the overall direct costs of asthma may be reduced due to fewer exacerbations. In addition, indirect costs due to lost productivity and mortality are reduced and patients have an improved quality of life. Inhaled corticosteroids are first-line therapy in the treatment of persistent asthma. Against this background, we have assessed the cost-effectiveness of Symbicort (budesonide and formoterol in a single inhaler), a treatment that provides better control of asthma compared with budesonide alone. While the prescribing costs of Symbicort were found to be higher than for budesonide alone, these were partially offset by reduced costs due to fewer asthma exacerbations and a reduced need for other medications. Combined long-term therapy with budesonide and formoterol also improves patient quality of life compared with budesonide alone. Two other factors associated with asthma treatment success and cost-effectiveness are patient/physic an education and good patient adherence to prescribed therapy. The introduction of a single inhaler that is easy to use in simple treatment regimens may improve patient adherence to prescribed medication, thus resulting in improved asthma control and fewer exacerbations. Treatment with Symbicort is more cost-effective than treatment with budesonide alone.
authors.affiliation: Karolinska Hospital, Stockholm, Sweden. olle.zetterstrom@lio.se
authors.lastname: Zetterström
authors.forename: R
authors.initials: R
authors.lastname: Buhl
authors.forename: H
authors.initials: H
authors.lastname: Mellem
authors.forename: F
authors.initials: F
authors.lastname: Andersson
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000191:economics; D001315:Australia; D001993:Bronchodilator Agents / Q000191:economics / Q000627:therapeutic use*; D019819:Budesonide / Q000008:administration & dosage* / Q000191:economics; D000069502:Budesonide, Formoterol Fumarate Drug Combination; D002170:Canada; D002648:Child; D003362:Cost-Benefit Analysis / Q000379:methods; D004338:Drug Combinations; D004983:Ethanolamines / Q000008:administration & dosage* / Q000191:economics; D000068759:Formoterol Fumarate; D006801:Humans; D009330:Nebulizers and Vaporizers; D011788:Quality of Life; D013548:Sweden; D016896:Treatment Outcome; D006113:United Kingdom; D014481:United States
chemical_list: D000305:Adrenal Cortex Hormones; D001993:Bronchodilator Agents; D000069502:Budesonide, Formoterol Fumarate Drug Combination; D004338:Drug Combinations; D004983:Ethanolamines; D019819:Budesonide; D000068759:Formoterol Fumarate