[Selected parameters of the oxidative-antioxidative balance in children with bronchial asthma exacerbations].
The aim of this study was to evaluate the involvement of selected parameters of oxidative-antioxidative system in children with bronchial asthma exacerbations. In my study the intensity of lipid peroxidation was calculated by the contents of malolonic dialdehyd in plasma. In order to evaluate activity of antioxidative system I investigated vitamin E concentration and total antioxidants status in serum, as well as activity of glutathione peroxidase and superoxide dismutase in blood. My study was performed on 32 children treated for exacerbations of bronchial asthma. The control group consisted of 27 healthy children. The study has revealed that children suffering from bronchial asthma exhibit disturbances in the oxidative-antioxidative balance, manifested by increased oxidative activity and by changes in certain parameters of the antioxidative system. It should be emphasized that disturbances in the oxidative/antioxidative balance were observed in the period of clinical exacerbation of asthma, as well as in the period of clinical remission. This fact may constitute further evidence for a prolonged existence of minimal inflammation in the respiratory tract in bronchial asthma.
Postepski
J
J
Klinika Pediatrii, Chorób Płuc i Reumatologii AM w Lublinie.
D000208:Acute Disease; D001249:Asthma / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000276:immunology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000276:immunology; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors; D014810:Vitamin E / Q000097:blood
D015415:Biomarkers; D014810:Vitamin E; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase