title: Autonomic functions in Buerger's disease.
abstract: One of the pathophysiological features in Buerger's disease, i.e. thromboangitis obliterans (TAO), is vasospastic phenomena. So autonomic reactivity was evaluated in 12 patients of Buerger's disease (1-6 years duration) and compared to age and sex matched controls (nonsmokers). Basal heart rate was significantly (P < 0.001) higher without any variation in blood pressure in TAO group compared to controls. Valsalva ratio (P < 0.01) and 30:15 ratio (P < 0.001) were increased without any effect on E:I ratio in TAO group versus controls. On head up tilt (HUT), there was significant (P < 0.001) fall in blood pressure in TAO group compared to controls. On cold pressure test (CPT), systolic blood pressure was reduced significantly (P < 0.01) in TAO group than that of controls, however, diastolic blood pressure showed no change in two groups. Responses indicate towards lower sympathetic reactivity in Buerger's patients.
authors.affiliation: Department of Physiology, Pt. B. D. Sharma, Postgraduate, Institute of Medical Sciences (PGIMS), Rohtak-124 001.
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Sood
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology*; D001794:Blood Pressure; D006339:Heart Rate; D006801:Humans; D008297:Male; D013919:Thromboangiitis Obliterans / Q000503:physiopathology*