title: Longitudinal study of trachomatous trichiasis in the Gambia.
abstract: OBJECTIVE
  Investigation of the natural history of trachomatous trichiasis in the Gambia and of the outcome of self epilation and surgery for the condition.
  
  
  METHODS
  A 1 year longitudinal study of 190 subjects with trichiasis was performed. Major trichiasis cases (five lashes or more) were referred for surgery and minor trichiasis cases were advised to epilate. Outcome measures included progression of trichiasis and corneal scarring; attendance for and results of surgery.
  
  
  RESULTS
  34 of 148 (23%, 95% CI 16 to 31) subjects with major trichiasis attended for surgery over the year. Progression from minor to major trichiasis occurred in 18 of 55 subjects (33%, 95% CI 21 to 47). Progression of corneal scarring occurred in 60 of 167 patients (36%, 95% CI 29 to 44). Clinically active trachoma and conjunctival bacterial isolation predicted progression of corneal opacity. Surgery was successful in 39 of 54 (72%) eyes.
  
  
  CONCLUSIONS
  Despite the overall decline in trachoma in the Gambia, patients with both minor and major trichiasis remain at risk of developing corneal opacity. Active trachomatous inflammation and additional infection with bacteria may accelerate this process. Antibiotic treatment for trichiasis patients (in addition to surgery) should be investigated. Surgery for minor trichiasis may be indicated. Regular audit of surgical results is necessary with retraining where needed.
authors.affiliation: International Centre for Eye Health, 11-43 Bath Street, London EC1V 9EL, UK. richardbowman@iceh.freeserve.co.uk
authors.forename: R J C
authors.initials: RJ
authors.lastname: Bowman
authors.forename: H
authors.initials: H
authors.lastname: Faal
authors.forename: M
authors.initials: M
authors.lastname: Myatt
authors.forename: R
authors.initials: R
authors.lastname: Adegbola
authors.forename: A
authors.initials: A
authors.lastname: Foster
authors.forename: G J
authors.initials: GJ
authors.lastname: Johnson
authors.forename: R L
authors.initials: RL
authors.lastname: Bailey
mesh_terms: D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005140:Eyelashes; D005141:Eyelid Diseases / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D005714:Gambia / Q000453:epidemiology; D006201:Hair Diseases / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy; D006204:Hair Removal / Q000379:methods*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D014141:Trachoma / Q000453:epidemiology* / Q000628:therapy