Frequency of adverse drug reactions in children: a prospective study.
OBJECTIVE
To assess the frequency of adverse drug reactions (ADRs) in children in France.


METHODS
In a prospective study over a period of 1 week, we evaluated the incidence of ADRs (1) as a cause of admission to a regional children's hospital; (2) occurring during hospitalization in a regional children's hospital; and (3) as a cause of consultation with private paediatricians.


RESULTS
Four out of 260 children were admitted to the regional children's hospital for ADRs (1.53% [0.42, 3.89]) and six developed ADRs during hospitalization (2.64% [0.97, 5.66]), 4/428 attended the Accident and Emergency Department for ADRs (0.93% [0.25, 2.37]) and 8/1192 consulted a private paediatrician for ADRs (0.67% [0.29, 1.31]).


CONCLUSIONS
Our results are in agreement with the incidence of ADRs in children found in others countries.
Jonville-Béra
Annie Pierre
AP
Department of Clinical Pharmacology and Regional Drug Monitoring Centre, University Hospital of Tours, 2 boulevard Tonellé, 37044 Tours Cedex, France. jonville-bera@chu-tours.fr
Giraudeau
Bruno
B
Blanc
Pascal
P
Beau-Salinas
Frèdèrique
F
Autret-Leca
Elisabeth
E
D002648:Child; D002675:Child, Preschool; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005602:France / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008297:Male; D011446:Prospective Studies