[Paclitaxel (Taxol) in chemotherapy of head and neck cancer--just another proposal or breakthrough?].
The examples of so far application of taxol in head and neck cancer are not completely clear. This is the first representative of a totally new group of cytostatics known as taxones. Presently, paclitaxel (TAXOL) is the anti-cancer drug commonly used in ovary cancer patients, resistant to platinum analogues. Taxones have the different functioning than the other anti-cancer drugs. They are responsible for originating microtubules and their further stabilisation. Moreover, paclitaxel (TAXOL) is a chemical compound sensitizing tumor cells for ionizing radiation. The authors are trying to specify the role of taxones nowadays and for the future use.
Górecka
K M
KM
Zakład Genetyki Człowieka PAN w Poznaniu.
Golusiński
W
W
Gawecki
W
W
Szyfter
K
K
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D008870:Microtubules / Q000187:drug effects; D017239:Paclitaxel / Q000494:pharmacology* / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D011838:Radiation-Sensitizing Agents; D017239:Paclitaxel