[Detection of C gene mutation strain in vertical transmission of hepatitis B virus and its significance].
OBJECTIVE
This study aims at detecting C gene mutation strain in vertical transmission of hepatitis B virus (HBV).


METHODS
HBV C gene nt 2,022 - 2,321 was directly sequenced.


RESULTS
Homology of HBV nucleotide sequence and amino acid sequence in mothers, fathers and their fetus was 100%. Mutation of 2,189 and 2,288 nucleotide of C gene resulted in substitution at the 97th and 130th amino acids.


CONCLUSIONS
C gene mutation strain is present in vertical transmission of HBV. Presence of mutation strain may be the cause of failure in vaccination.
Wang
S
S
Institute of Military Medicine, Guangzhou Command PLA, Guangzhou, 510507, China.
Jiang
P
P
Peng
G
G
Zeng
N
N
Wang
Z
Z
D000328:Adult; D004252:DNA Mutational Analysis; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006509:Hepatitis B / Q000635:transmission* / Q000821:virology; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D009154:Mutation; D011247:Pregnancy; D017385:Sequence Homology; D014611:Vaccination
D004279:DNA, Viral; D017325:Hepatitis B Vaccines