[Studies on the spatial and familial aggregation of double Y nuclear family in gastric cancer pedigree].
OBJECTIVE
To explore whether there existed spatial and familial aggregation in gastric cancer in Yangzhong City of Jiangsu Province.


METHODS
Using the data collected from cancer incidence registry and report system in Yangzhong City and newly designed investigation for double Y nuclear family, a genetic epidemiological study was conducted in 448 nuclear pedigrees with gastric cancer and 437 control pedigrees, involving 5 242 family members.


RESULTS
Chi square test of goodness-of-fit for Poisson distribution showed there was difference between real incidence rate of gastric cancer in all townships and towns in Yangzhong and expected distribution, with chi(2) = 191.07, P < 0.001. The highest rate was in Sanyao, Changhong and Youfang townships, which was 2.2 times higher as that in the areas with low-incidence rate. Prevalence rate of gastric cancer was significantly higher in the siblings (5.42%) and parents (8.65%) of the probands, than that in siblings and parents of their spouses (4.94% and 3.20%, respectively). Prevalence rate of gastric cancer in the offspring with both parents suffered from gastric cancer was the highest, 22.58%. Test for goodness-of-fit of binominal distribution showed that there was significant difference between observed number and expected number of pedigrees with gastric cancer, with P < 0.0001.


CONCLUSIONS
There was not only significantly spatial aggregation of gastric cancer in Yangzhong City, but also familial aggregation, which coincided with a mode of multi-genetic inheritance based on preliminary results and laid a foundation for exploring the difference in gentic susceptibilities and environmental factors for gastric cancer in Yangzhong City.
Shen
J
J
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100083, China.
Xing
H
H
Wang
L
L
D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009679:Nuclear Family; D010375:Pedigree; D015995:Prevalence; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000235:genetics*