title: Spatial and temporal pattern of Fgf-8 expression during chicken development.
abstract: This study analyzes the temporal and spatial expression pattern of Fgf-8 over a continuous series of developmental stages. Special emphasis is laid on the paraxial mesoderm where Fgf-8 expression is highly dynamic. Whereas the anterior portion of the unsegmented mesoderm is devoid of expression, Fgf-8 is upregulated in the posterior half of a newly formed somite. Soon after somite formation, this highly localized expression gives way to a more diffuse pattern of Fgf-8 expression at low levels in presumptive sclerotomal cells. During later somite maturation, transcripts become restricted to the myotome. Co-staining with the myotome marker MyoD reveals that Fgf-8 expression defines a subpopulation of muscle precursor cells.
authors.affiliation: Institute of Anatomy, University of Freiburg, P.O. Box 111, D-79001 Freiburg, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Stolte
authors.forename: Ruijin
authors.initials: R
authors.lastname: Huang
authors.forename: Bodo
authors.initials: B
authors.lastname: Christ
mesh_terms: D000818:Animals; D002642:Chick Embryo / Q000502:physiology*; D005314:Embryonic and Fetal Development; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D009024:Morphogenesis / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D019170:Somites / Q000378:metabolism
chemical_list: D009363:Neoplasm Proteins; D012333:RNA, Messenger; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors