title: Negishi coupling between alpha-alkyl(aryl)thio vinyl zinc chloride and alpha-bromo vinyl ether: a convergent synthesis of 2-alkoxy-3-alkyl(aryl)thiobuta-1,3-dienes.
abstract: [reaction: see text] A convergent approach for the stereoselective synthesis of 2-alkoxy-3-alkyl(aryl)thiobuta-1,3-dienes has been developed. It was found that Negishi coupling between alpha-alkyl(aryl)thio vinyl zinc chloride and alpha-bromo vinyl ether or Negishi coupling between alpha-bromo vinyl sulfide and alpha-alkoxy vinyl zinc chloride provided the best yield and stereoselectivity.
authors.affiliation: Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Mei
authors.initials: M
authors.lastname: Su
authors.forename: Ying
authors.initials: Y
authors.lastname: Kang
authors.forename: Wensheng
authors.initials: W
authors.lastname: Yu
authors.forename: Zhengmao
authors.initials: Z
authors.lastname: Hua
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Jin