[The characteristics of bcl-2 and PCNA expression in the lens epithelium of human being].
OBJECTIVE
To investigate the characteristics of bcl-2 (gene inhibiting apoptosis) and proliferating cell nuclear antigen (PCNA) expression and their relation to the proliferation of lens epithelium.


METHODS
The expression of bcl-2 and PCNA were detected by immunohistochemical streptavidin-peroxidase (SP) method.


RESULTS
The expression of bcl-2 and PCNA in the lens epithelium of fetus and children was higher than that of the elderly, especially in the region of the lens equator.


CONCLUSIONS
The over-expression of bcl-2 and PCNA in the lens epithelium of fetus and children suggests that bcl-2 and PCNA might be related to the development of cataract.
Weng
J
J
Department of Ophthalmology, Fujian Medical University, Fuzhou 350001, China.
Zhang
H
H
D000293:Adolescent; D000367:Age Factors; D002648:Child; D004847:Epithelial Cells / Q000737:chemistry* / Q000166:cytology; D005333:Fetus; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007908:Lens, Crystalline / Q000737:chemistry* / Q000196:embryology / Q000254:growth & development; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*
D018809:Proliferating Cell Nuclear Antigen; D019253:Proto-Oncogene Proteins c-bcl-2