Modulation of Na, K-ATPase activity by immunoglobulins--III. Influence of an ATPase activity regulating agent "Marina" on Na, K-ATPase activity in patients with various chronic disturbances.
BACKGROUND
In some earlier work we have demonstrated that hypotonic mineral water can change the functional activity of Na, K-ATPase both in vitro and in vivo. The current investigation was aimed at measuring of the functional activity of ATPase in erythrocytes from blood samples of patients before and after treatment with the artificially mineralised water "Marina".


METHODS
"Marina"--an artificial mineral water containing K+ and Mg2+ ions, was investigated by double-blind method. Treatment lasted 7 days, daily intake of "Marina" was 4 x 200 ml before meals. Na, K-ATPase activity in erythrocytes and a number of clinical indices was determined before and after the treatment.


RESULTS
After the intake of the preparation "Marina" the normal activity pattern of the Na, K-ATPase in chronic active hepatitis or atherosclerosis patients was restored. The restoration of the Na, K-ATPase activity brought about the normalization of vital clinical indices.


CONCLUSIONS
The summarized data from the in vitro and in vivo experiments point to formation of Na, K-ATPase and immunoglobulin complexes as possible cause of cell disfunction and source of organic disturbances.
Ponomarenko
E
E
Latvian Academy of Medicine. jelena_p99@yahoo.com
Pokrotnieks
J
J
Jirgensons
J
J
Seleznevs
J
J
Danilans
A
A
Shubnikova
N
N
Kalvins
I
I
D001161:Arteriosclerosis / Q000201:enzymology; D002908:Chronic Disease; D004311:Double-Blind Method; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006521:Hepatitis, Chronic / Q000201:enzymology*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D008297:Male; D008900:Mineral Waters; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D007136:Immunoglobulins; D008900:Mineral Waters; D000254:Sodium-Potassium-Exchanging ATPase