Some biological and biochemical activities of resormycin, a novel herbicidal antibiotic.
Biological and biochemical activities of resormycin were studied using unicellular green algae, Selenastrum capricornutum (abbreviated as Selena.), as a test organism. Resormycin inhibited the growth in vitro of Selena. more strongly in the dark than in the light. A weaker but more photo-stable derivative, (+/-)-2,3-dihydro-resormycin, showed more long-lasting activity against Selena. in the light. Resormycin started killing Selena. only after exposure for 2 days and longer, even at high concentrations. Resormycin at concentrations near IC50 rapidly inhibited incorporation of 3H-leu, but not 3H-UR or 3H-TdR, into the TCA insoluble fraction of Selena. Herbicidal activity of resormycin was confirmed using some crops and weeds.
Igarashi
M
M
Institute of Microbial Chemistry, Tokyo, Japan. igarashim@bikaken.or.jp
Kawada
M
M
Hamada
M
M
Iinuma
H
H
Hayashi
H
H
Tsuchiya
K
K
Hori
M
M
D000935:Antifungal Agents / Q000494:pharmacology*; D063245:Plant Development; D010940:Plant Proteins / Q000096:biosynthesis; D010944:Plants / Q000187:drug effects*; D011422:Propionates / Q000494:pharmacology*
D000935:Antifungal Agents; D010940:Plant Proteins; D011422:Propionates; C111138:resormycin