title: Molecular Dissection of the Murine IL-1beta Promoter.
abstract: Interleukin-1 (IL-1) is involved in a broad range of biological activities that affect immunological, inflammatory, and nonimmunological responses. Although the role of the IL-1 proteins in normal physiological responses in vivo remains incompletely defined, there is substantial evidence that excessive production of IL-1 contributes to the pathogenesis of many illnesses with autoimmune or inflammatory components, including rheumatoid and osteoarthritis, type I diabetes mellitus and atherosclerosis. Despite numerous reports on IL-1 regulation, very little is known regarding the molecular details of IL-1 production, particularly at the transcription level. This review will focus on our studies of transcriptional regulation of the murine IL-1beta gene and, where appropriate, comparison to similar studies of the human IL-1beta gene. A basic understanding at this level should lead to effective pharmacological intervention and, ultimately, to control of inflammatory disease.
authors.affiliation: Department of Internal Medicine, Washington University School of Medicine, St. Louis, USA.
authors.forename: Sandip A.
authors.initials: SA
authors.lastname: Godambe
authors.forename: David D.
authors.initials: DD
authors.lastname: Chaplin
authors.forename: Tsetska
authors.initials: T
authors.lastname: Takova
authors.forename: Clifford J.
authors.initials: CJ
authors.lastname: Bellone