Treatment of paediatric Hodgkin's disease. a balance of risks.
Hodgkin's disease is one of the commoner malignancies presenting in adolescence and young adulthood and is curable in the majority of cases. A number of therapeutic regimens have been used successfully, often at the expense of the development of side-effects in later life, including second malignancies, infertility and cardiac disease. We discuss the challenge faced by paediatric oncologists today in finding the balance between maximising cure and minimising the late effects.
Thomson
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AB
Department of Haematology/Oncology, Royal Hospital for Sick Children, 17 Millerfield Place, EH9 1LW, Edinburgh, UK.
Wallace
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WH
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000139:chemically induced; D006331:Heart Diseases / Q000139:chemically induced; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D007223:Infant; D007248:Infertility, Male / Q000139:chemically induced; D008297:Male; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced; D011878:Radiotherapy / Q000009:adverse effects; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis; D013959:Thyroid Diseases / Q000139:chemically induced; D013995:Time