title: National Human Exposure Assessment Survey: analysis of exposure pathways and routes for arsenic and lead in EPA Region 5.
abstract: The National Human Exposure Assessment Survey (NHEXAS) Phase I field study conducted in EPA Region 5 (Great Lakes Area) provides extensive exposure data on a representative sample of approximately 250 residents of the region. Associated environmental media and biomarker (blood, urine) concentration data were also obtained for the study participants to aid in understanding of the relationships of exposures to both contaminant pathways and doses. Besides fulfilling the primary NHEXAS objectives, the NHEXAS data provided an opportunity to explore secondary usages, such as examining pathway to route of exposure relationships. A generic type of structural equation model was used to define the anticipated relationships among the various data types for both arsenic (As) and lead (Pb). Since, by design, only a few participants provided data for all sample types, implementing this model required that some media concentrations (outdoor air and soil) be imputed for subjects with missing information by using measurements collected in the same geographic area and time period. The model, and associated pairwise correlations, generally revealed significant but weak associations among the concentrations, exposures, and doses; the strongest associations occurred for the various air measurements (indoor versus outdoor and personal). The generally weak associations were thought to be partly due to the absence of complete coverage of nonresidential environmental media and to nonsynchronization of relevant measurement times and integration periods of collection across the various sample types. In general, relationships between the NHEXAS questionnaire data and the various concentration, exposure, and body-burden measures were also weak. The model results and the modeling exercise suggest several ways for optimizing the design of future exposure assessment studies that are aimed at supporting structural modeling activities.
authors.affiliation: Research Triangle Institute, 3040 Cornwallis Road, Research Triangle Park, North Carolina 27709, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Clayton
authors.forename: E D
authors.initials: ED
authors.lastname: Pellizzari
authors.forename: J J
authors.initials: JJ
authors.lastname: Quackenboss
mesh_terms: D000397:Air Pollution / Q000032:analysis; D001151:Arsenic / Q000032:analysis*; D001822:Body Burden; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D007854:Lead / Q000032:analysis*; D015146:Midwestern United States; D015233:Models, Statistical; D012044:Regression Analysis; D012989:Soil Pollutants / Q000032:analysis; D011795:Surveys and Questionnaires; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D012989:Soil Pollutants; D007854:Lead; D001151:Arsenic