Risk factors for the transmission of methicillin-resistant Staphylococcus aureus in an adult intensive care unit: fitting a model to the data.
Little is known about the amount of cross-transmission, the risk factors for infection, and the relative effectiveness of infection control procedures when methicillin-resistant Staphylococcus aureus (MRSA) infection occurs at highly endemic levels in intensive care units. A cohort study was done to identify exposures associated with cases that likely were the result of cross-transmission (i.e., occurring in clusters and with indistinguishable MRSA macrorestriction profiles). Fitting a simple stochastic model to the ascertained data allowed prediction of the effectiveness of infection control measures. Exposure to relative staff deficit (adjusted rate ratio, 1.05 independent; 95% confidence interval, 1.02-1.09) was the only factor significantly associated with potential transmission (P =.001). It was predicted that a 12% improvement in adherence to hand-hygiene policies might have compensated for staff shortage and prevented transmission during periods of overcrowding, shared care, and high workload but that this would be hard to achieve.
Grundmann
Hajo
H
Division of Microbiology and Infectious Diseases, University Hospital Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom. Hajo.Grundmann@Nottingham.ac.uk
Hori
Satoshi
S
Winter
Bob
B
Tami
Adriana
A
Austin
Daren J
DJ
D016000:Cluster Analysis; D003428:Cross Infection / Q000209:etiology* / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D007362:Intensive Care Units; D016106:Methicillin Resistance; D008954:Models, Biological; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000209:etiology* / Q000517:prevention & control / Q000635:transmission; D013211:Staphylococcus aureus / Q000187:drug effects*