title: Conception and spontaneous delivery after total hypophysectomy.
abstract: OBJECTIVE
  To report the first case of pregnancy and spontaneous delivery after total hypophysectomy.
  
  
  METHODS
  A case report.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A 34-year-old woman with panhypopituitarism after hypophysectomy in childhood for craniopharyngioma.
  
  
  METHODS
  Successful fertility treatment followed by sufficient hormone substitution therapy during pregnancy.
  
  
  METHODS
  Clinical variables.
  
  
  RESULTS
  The patient had an uncomplicated spontaneous delivery without any substitution of oxytocin before, during, or after delivery.
  
  
  CONCLUSIONS
  Normal pregnancy and delivery are possible in women with lack of pituitary function. Maternal pituitary oxytocin release seems to play a limited role in the onset and progression of labor.
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Mannheim, Mannheim, Germany. joachim.volz@gyn.ma.uni-heidelberg.de
authors.forename: Joachim
authors.initials: J
authors.lastname: Volz
authors.forename: Udo
authors.initials: U
authors.lastname: Heinrich
authors.forename: Stefanie
authors.initials: S
authors.lastname: Volz-Köster
mesh_terms: D000328:Adult; D003397:Craniopharyngioma / Q000532:radiotherapy / Q000601:surgery; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D005260:Female; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007016:Hypophysectomy; D008297:Male; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D006490:Hemostatics; D003894:Deamino Arginine Vasopressin; D013974:Thyroxine; D006854:Hydrocortisone