Toxic epidermal necrolysis induced by nevirapine therapy: description of two cases and review of the literature.
We describe two cases of toxic epidermal necrolysis developed during an antiretroviral therapy regimen containing nevirapine. It seems likely that the poor adherence to the dose escalation regimen of nevirapine has caused this life-threatening disease. A complete and written information on the scheduled antiretroviral therapy is mandatory, above all for individuals coming from developing countries where language barriers have not yet been successfully overcome.
Cattelan
A M
AM
Division of Infectious Diseases, General Hospital of Padua, Italy. aacattelan@hotmail.com
Trevenzoli
M
M
Sasset
L
L
Sgarabotto
D
D
Lanzafame
M
M
Meneghetti
F
F
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003144:Communication Barriers; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D019829:Nevirapine / Q000008:administration & dosage / Q000009:adverse effects*; D010349:Patient Compliance; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000209:etiology*
D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors; D019829:Nevirapine