[Orthotopic liver transplantation for end-stage liver diseases in 71 cases].
OBJECTIVE
To assess the role of orthotopic liver transplantation (OLT) in the treatment of end-stage liver diseases and to discuss the experience of the operation.


METHODS
Retrospective analysis of clinical data of 71 cases of liver transplantation was performed in our hospital from April 1993 to August 2001.


RESULTS
One year survival rate of recipients with benign hepatic disease was over 75%. The survival time and life quality of malignant recipients were also improved. Lamivudine monotherapy during the operation period could reduce HBV reinfection rate. The practice of OLT without veno-venous bypass (VVB) was associated with a shorter operating time, less hemorrhape, and thus less blood transfusion during the operation compared with standard technique of OLT with routine use of VVB. The occurrence rate of biliary complications was 5.98% and vascular complication 8.96%.


CONCLUSIONS
OLT should become a routine therapeutic choice for end-stage liver diseases. Lamivudine is helpful to reduce HBV reinfection after OLT in HBV-related liver diseases. OLT without VVB is safe and can be performed in the majority of adult patients. The early diagnosis and timely application of interventional radiological technique are important for the treatment of biliary and vascular complications.
Zheng
Shusen
S
Department of Hepatobiliary Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Huang
Dongsheng
D
Wang
Weilin
W
Liang
Tingbo
T
Zhang
Min
M
Shen
Yan
Y
Wu
Jian
J
Xu
Xiao
X
Lu Aw
An-wei
AW
Liao Sy
Sheng-yang
SY
D000293:Adolescent; D000328:Adult; D001660:Biliary Tract Diseases / Q000517:prevention & control / Q000821:virology; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000517:prevention & control*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008107:Liver Diseases / Q000401:mortality*; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control / Q000821:virology; D012189:Retrospective Studies; D015996:Survival Rate; D014652:Vascular Diseases / Q000517:prevention & control / Q000821:virology
D019259:Lamivudine