Oxygen consumption after hypothermic cardiopulmonary bypass: the effect of continuing a propofol infusion postoperatively.
OBJECTIVE
To evaluate the effect of a fixed rate of infusion of propofol on total body oxygen consumption during the postoperative rewarming phase after cardiopulmonary bypass.


METHODS
Prospective, randomized, controlled study.


METHODS
Cardiac intensive care unit, university hospital.


METHODS
Twenty-four male and female patients undergoing elective first-time coronary artery bypass graft surgery.


METHODS
Total body oxygen consumption was measured using a pulmonary artery catheter and thermodilution during postoperative rewarming. Twelve patients had propofol infused at 2 mg/kg/h for 4 hours or until rewarmed.


RESULTS
Total body oxygen consumption was reduced in the propofol group compared with the control group. Oxygen consumption was a median of 30.0 mL/min/m(2) less in the patients receiving propofol (p = 0.01). One patient receiving propofol shivered compared with 4 in the control group (p = 0.14).


CONCLUSIONS
Administration of propofol during postoperative rewarming reduces total body oxygen consumption and may reduce shivering.
Milne
Stewart E
SE
Department of Anaesthesia, Glasgow Royal Infirmary, Glasgow, United Kingdom. smilne@umich.edu
James
Kenneth S
KS
Nimmo
Susan
S
Hickey
Stephen
S
D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*; D011182:Postoperative Care; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology; D011446:Prospective Studies; D017694:Rewarming / Q000379:methods; D013815:Thermodilution
D018686:Anesthetics, Intravenous; D015742:Propofol