Clinical significance of serum antibody against neuron-specific enolase in glaucoma patients.
OBJECTIVE
In a recent study, we found the presence of serum autoantibody against neuron-specific enolase (NSE) in glaucoma patients. The purpose of the present paper is to investigate further the clinical significance of the presence of the serum antibody against NSE in glaucoma patients.


METHODS
Serum autoantibody against NSE was examined by Western blot analysis in 143 patients with glaucoma (normal tension glaucoma [NTG], 45 cases; primary open angle glaucoma [POAG] 98 cases). Clinical characteristics including visual acuity, visual field, intraocular pressure (IOP), and optic disc features were compared between the serum autoantibody-positive and the serum autoantibody-negative patients.


RESULTS
Maximum IOP in the serum anti-NSE antibody-positive patients was significantly lower than that in the negative patients (P <.05). However, no statistical differences were observed in visual field loss, disc cupping, or other clinical factors. During the clinical course, rates of the presence of anti-NSE antibody were significantly higher in the early stages of POAG (P <.0001) with visual field deterioration than without it. Although it was not statistically significant, the positive rates of serum anti-NSE antibody were relatively higher in the later stages of POAG and NTG with visual field deterioration than without it.


CONCLUSIONS
The present observations suggest that the presence of serum autoantibody against NSE may be clinically useful for predicting the progression of visual field loss in POAG patients.
Ikeda
Yoko
Y
Department of Ophthalmology, Kyoto Prefectural University School of Medicine, Kyoto, Japan.
Maruyama
Ikuyo
I
Nakazawa
Mitsuru
M
Ohguro
Hiroshi
H
D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D015153:Blotting, Western; D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000276:immunology*; D014786:Vision Disorders / Q000503:physiopathology; D014792:Visual Acuity; D014794:Visual Fields
D001323:Autoantibodies; D001324:Autoantigens; D010751:Phosphopyruvate Hydratase