Analysis of IL-18 bioactivity and IL-18 mRNA in three patients with adult T-cell leukaemia, acute mixed lineage leukaemia, and acute lymphocytic leukaemia accompanied with high serum IL-18 levels.
Interleukin-18 (IL-18) bioactivity in sera and IL-18 mRNA expression in leukaemia cells of three patients with adult T-cell leukaemia (ATL), acute mixed lineage leukaemia (AMLL) and acute lymphocytic leukaemia (ALL) accompanied with high serum IL-18 levels have been analysed. There was little serum IL-18 bioactivity in the three patients with ATL, AMLL and ALL, while IL-18 mRNA expression was detected in leukaemia cells of all three patients.
Takubo
T
T
Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University, Japan. m3542254@med.osaka-cu.ac.jp
Kumura
T
T
Kanashima
H
H
Nakao
T
T
Nakamae
H
H
Aoyama
Y
Y
Yamamura
R
R
Ohta
T
T
Koh
K R
KR
Ohta
K
K
Yamane
T
T
Hino
M
M
Kamitani
T
T
Tatsumi
N
N
D000208:Acute Disease; D000368:Aged; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis / Q000187:drug effects; D020382:Interleukin-18 / Q000097:blood / Q000235:genetics / Q000502:physiology*; D007938:Leukemia / Q000097:blood* / Q000378:metabolism; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D020382:Interleukin-18; D012333:RNA, Messenger; D007371:Interferon-gamma