Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I.
Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis I, prove to encode subunits of the anaphase-promoting complex or cyclosome (APC/C). RNA interference studies reveal that these and other APC/C subunits are essential for the segregation of chromosomal homologs during meiosis I. Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion.
Davis
Edward S
ES
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0840, USA.
Wille
Lucia
L
Chestnut
Barry A
BA
Sadler
Penny L
PL
Shakes
Diane C
DC
Golden
Andy
A
D000595:Amino Acid Sequence; D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D020090:Chromosome Segregation / Q000502:physiology; D004252:DNA Mutational Analysis; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology; D008025:Ligases / Q000235:genetics* / Q000502:physiology; D008540:Meiosis / Q000502:physiology*; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D010750:Phosphoproteins; D021122:Protein Subunits; D012330:RNA, Double-Stranded / Q000235:genetics / Q000502:physiology; D029702:Schizosaccharomyces pombe Proteins; D016415:Sequence Alignment; D013489:Suppression, Genetic / Q000235:genetics / Q000502:physiology; D043743:Ubiquitin-Protein Ligase Complexes; D000097722:Cohesins
D064173:Anaphase-Promoting Complex-Cyclosome; D005656:Fungal Proteins; D008025:Ligases; D010750:Phosphoproteins; D021122:Protein Subunits; D012330:RNA, Double-Stranded; D029702:Schizosaccharomyces pombe Proteins; D043743:Ubiquitin-Protein Ligase Complexes; C077081:REC8 protein, S pombe; D000097722:Cohesins