title: Fluoroalkyl alpha,beta-unsaturated imines. Valuable synthetic intermediates from primary fluorinated enamine phosphonates.
abstract: [reaction: see text] A simple method for the preparation of fluoroalkyl allylamines or alpha,beta-unsaturated ketones by an olefination reaction of primary enamine phosphonates and aldehydes, followed by selective reduction with hydrides or hydrolysis, is reported. Fluorinated beta-amino nitriles are also obtained by an olefination reaction of primary enamine phosphonates with aldehydes and subsequent addition of metalated acetonitrile.
authors.affiliation: Departamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco, Apartado 450, 01080 Vitoria, Spain. qoppagaf@vf.ehu.es
authors.forename: Francisco
authors.initials: F
authors.lastname: Palacios
authors.forename: Sergio
authors.initials: S
authors.lastname: Pascual
authors.forename: Julen
authors.initials: J
authors.lastname: Oyarzabal
authors.forename: Ana M
authors.initials: AM
authors.lastname: Ochoa De Retana