[Activity of serum paraoxonase and its polymorphism in healthy Chinese of Shanghai].
OBJECTIVE
To study activity of serum paraoxonase and its polymorphic distribution in healthy people of Shanghai and to set a reference value for it.


METHODS
Serum activities of paraoxonase, salt-stimulated paraoxonase and arylesterase were measured in 198 subjects (105 males and 93 female, aged 21 - 61 years) in Shanghai. Three phenotypes of serum paraoxonase could be distinguished based on the ratio of salt-stimulated paraoxonase activity and paraoxonase activity and the ratio of salt-stimulated paraoxonase activity and arylesterase. Its gene frequency was calculated according to Hardy-Weinberg equation.


RESULTS
Activity of serum paraoxonase was 97.6 - 472.1 unit. There was no difference in serum paraoxonase activity between male and female, nor among different ages. It was found that 27 persons in low, 71 in medium and 100 in high activity. Gene frequency of low activity (PON * A) and high activity (PON * B) was 0.369 and 0.631, respectively.


CONCLUSIONS
Distribution of serum paraoxonase in healthy people of Shanghai was different from that in Caucasians.
Zhou
Z
Z
School of Public Health, Shanghai Medical University, Shanghai, 200032, China.
Wu
H
H
Zhou
J
J
Xue
S
S
D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood* / Q000235:genetics*; D044466:Asian People; D002265:Carboxylic Ester Hydrolases / Q000097:blood / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D012016:Reference Values
D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase