Plakins: a family of versatile cytolinker proteins.
By connecting cytoskeletal elements to each other and to junctional complexes, the plakin family of cytolinkers plays a crucial role in orchestrating cellular development and maintaining tissue integrity. Plakins are built from combinations of interacting domains that bind to microfilaments, microtubules, intermediate filaments, cell-adhesion molecules and members of the armadillo family. Plakins are involved in both inherited and autoimmune diseases that affect the skin, neuronal tissue, and cardiac and skeletal muscle. Here, we describe the members of the plakin family and their interaction partners, and give examples of the cellular defects that result from their dysfunction.
Leung
Conrad L
CL
Dept of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Green
Kathleen J
KJ
Liem
Ronald K H
RK
D000595:Amino Acid Sequence; D000818:Animals; D001324:Autoantigens / Q000737:chemistry / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000378:metabolism; D002352:Carrier Proteins; D003094:Collagen / Q000737:chemistry / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000378:metabolism*; D051180:Desmoplakins; D000071821:Dystonin; D030342:Genetic Diseases, Inborn / Q000378:metabolism; D006801:Humans; D007381:Intermediate Filament Proteins / Q000737:chemistry / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D008840:Microfilament Proteins / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D051179:Plakins; D051190:Plectin; D011498:Protein Precursors / Q000737:chemistry / Q000378:metabolism*; D016415:Sequence Alignment / Q000379:methods; D000097805:Collagen Type XVII
D001324:Autoantigens; D002352:Carrier Proteins; D003094:Collagen; D003598:Cytoskeletal Proteins; D051180:Desmoplakins; D000071821:Dystonin; D007381:Intermediate Filament Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D051179:Plakins; D051190:Plectin; D011498:Protein Precursors; D000097805:Collagen Type XVII; C486268:DST protein, human; C095003:MACF1 protein, human; C490632:Macf1 protein, mouse; C495332:PLEC protein, human; C491674:PPL protein, human; C100754:envoplakin; C426678:epiplakin