title: Expression of Kin, a nuclear protein binding to curved DNA, in the brain of the frog (Rana esculenta), turtle (Trachemys scripta), quail (Coturnix coturnix) and mouse (Mus musculus).
abstract: The distribution of Kin protein, the vertebrate homologue of the bacterial recA nuclear protein involved in illegitimate recombinant DNA repair and gene regulation, was analysed in the brain of the mouse, quail, turtle and frog by immunocytochemical methods. The protein was expressed in all brains, but not in a uniform manner. Immunoreactivity was absent from major fibre tracts. In the cerebral nuclei, immunolabelling in the various species showed an important variation. A comparative analysis, based on the homologies between different brain structures in these species, showed that this variation was not due to interspecific variation but that of an ancestral pattern of distribution of Kin protein. It is also shown that whatever the species examined, Kin protein is consistently more highly expressed in those regions of the brain with a conservative evolutionary history (e.g. the olfactory and limbic systems, the hypothalamus, the monoaminergic system, the cerebellum, and the nuclei of sensory and motor cranial nerves). The protein is markedly less heavily expressed in the dorsal striatum and the sensory nuclei of the thalamus.
authors.affiliation: INSERM U-480, Neurobiologie des Etats de Sommeil et d'Eveil, Lyon, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Mermet
authors.forename: Jaime
authors.initials: J
authors.lastname: Angulo
authors.forename: M
authors.initials: M
authors.lastname: Médina
authors.forename: Jacques
authors.initials: J
authors.lastname: Repérant
authors.forename: Roger
authors.initials: R
authors.lastname: Ward
authors.forename: Sylvia
authors.initials: S
authors.lastname: Araneda
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003370:Coturnix; D004268:DNA-Binding Proteins / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D011893:Rana esculenta; D013045:Species Specificity; D014426:Turtles
chemical_list: D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; C071214:Kin protein, mouse