SCMTR: a chloride-selective, membrane-anchored peptide channel that exhibits voltage gating.
The design, synthesis, and characterization of a synthetic chloride membrane transporter, SCMTR (synthetic chloride membrane transporter, "scimitar"), are presented. The compound [CH3(CH2)17]2NCOCH2OCH2CO-GGGPGGG-OBzl inserts rapidly into liposomes and planar lipid bilayers. SCMTR has a 1.3 +/- 0.01 nS chloride diffusion pathway (>10:1 Cl/K selectivity). Evidence was also obtained for voltage gating behavior.
Schlesinger
Paul H
PH
Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.
Ferdani
Riccardo
R
Liu
Jun
J
Pajewska
Jolanta
J
Pajewski
Robert
R
Saito
Mitsuyoshi
M
Shabany
Hossein
H
Gokel
George W
GW
D018118:Chloride Channels / Q000138:chemical synthesis* / Q000737:chemistry; D015640:Ion Channel Gating; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D008564:Membrane Potentials; D010743:Phospholipids / Q000737:chemistry
D018118:Chloride Channels; D008051:Lipid Bilayers; D008081:Liposomes; D010743:Phospholipids