Association of calcitonin receptor gene polymorphism with early marginal bone loss around endosseous implants.
OBJECTIVE
This study investigated the relationship between calcitonin receptor (CTR) genotype and buccal marginal bone loss observed at stage II surgery for endosseous implants.


METHODS
A total of 237 implants were placed in 35 patients; 89 implants were placed in maxillae and 148 implants in mandibles. The CTR genetic polymorphism was examined by the polymerase chain reaction restriction fragment length polymorphism method.


RESULTS
Patients with the TC genotype were 20 times more likely to suffer buccal marginal bone loss in the mandible than patients with the CC genotype. Furthermore, there were no significant differences in the distribution of age, smoking status, postmenopausal women, and bone quality between patients with and without bone loss in either jaw.


CONCLUSIONS
These results suggest that the known risk factor for bone loss cannot explain the early marginal bone loss around the implants.


CONCLUSIONS
Although further genetic research should be conducted, it is suggested that the CTR genetic test could become a useful tool in the planning of treatment before implant surgery and lead to more predictable implant treatment.
Nosaka
Yasuhiro
Y
Department of Dentistry and Oral-Maxillofacial Surgery, Kobe Nishi City Hospital, Kobe, Japan. nosasen@aol.com
Tachi
Yoichi
Y
Shimpuku
Hitomi
H
Kawamura
Tatsuya
T
Ohura
Kiyoshi
K
D000328:Adult; D000368:Aged; D000483:Alleles; D016301:Alveolar Bone Loss / Q000209:etiology / Q000235:genetics*; D016009:Chi-Square Distribution; D003758:Dental Implantation, Endosseous / Q000009:adverse effects*; D015921:Dental Implants / Q000009:adverse effects*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000209:etiology / Q000235:genetics; D008439:Maxillary Diseases / Q000209:etiology / Q000235:genetics; D008875:Middle Aged; D016017:Odds Ratio; D012150:Polymorphism, Restriction Fragment Length; D018003:Receptors, Calcitonin / Q000235:genetics*
D015921:Dental Implants; D018003:Receptors, Calcitonin