[The effectiveness of cyclosporin A in the treatment of autoimmune hemolytic anemia and Evans syndrome].
OBJECTIVE
To test the therapeutic effectiveness of cyclosporin A (CsA) in combination with corticosteroid in the treatment of autoimmune hemolytic anemia(AIHA) and Evans syndrome.


METHODS
Forty-four cases of AIHA and Evans syndrome were treated with CsA in combination with a conventional regimen (prednisone + danazol) (18 cases) or conventional regimen alone(26 cases).


RESULTS
The complete response rate of CsA group (88.9%) was higher than that of conventional regimen group (57.7%) (P < 0.05), and the relapse rate was lower (3.3% vs 70%) (P < 0.01).


CONCLUSIONS
CsA in combination with conventional regimen can improve the complete response rate and reduce relapse of AIHA and Evans syndrome.
Liu
H
H
Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
Shao
Z
Z
Jing
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy*; D016572:Cyclosporine / Q000627:therapeutic use*; D003613:Danazol / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use*; D012008:Recurrence; D016896:Treatment Outcome
D016572:Cyclosporine; D003613:Danazol; D011241:Prednisone