title: Lepirudin anticoagulation for heparin-induced thrombocytopenia.
abstract: Lepirudin is indicated for anticoagulation in patients with heparin-induced thrombocytopenia (HIT). We describe 2 cases of HIT and thrombosis in children with heart disease, including one that required extracorporeal membrane oxygenation. Lepirudin, dosed in the recommended adult weight--based fashion, was an effective antithrombotic agent in pediatric patients with HIT.
authors.affiliation: Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Deitcher
authors.forename: Arthur P
authors.initials: AP
authors.lastname: Topoulos
authors.forename: John R
authors.initials: JR
authors.lastname: Bartholomew
authors.forename: Maryanne R
authors.initials: MR
authors.lastname: Kichuk-Chrisant
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000150:complications; D002648:Child; D002675:Child, Preschool; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D024764:Hirudin Therapy; D006629:Hirudins / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000925:Anticoagulants; D006629:Hirudins; D011994:Recombinant Proteins; C083544:lepirudin