title: Fiberoptic balloon catheter ablation of pulmonary vein ostia in pigs using photonic energy delivery with Diode laser.
abstract: Circumferential lesions to the pulmonary vein (PV) ostia to cause conduction block at the junction of the PV and left atrium could offer a new approach during catheter ablation of patients with paroxysmal (focal) atrial fibrillation. Diode laser can deliver energy through diffusing or ring fiber tips. In three pigs weighing between 60 and 65 kg, transseptal puncture was performed and a fiberoptic balloon catheter with a collapsed profile of 10 Fr was advanced through a sheath under fluoroscopic guidance to the ostium of the right and left PVs. The balloon was inflated with a 3-cc mixture of D2O (deuterium oxide) and contrast to deliver circumferential lesions with a 15-mm diameter x 3-mm ring width of light. Applications consisted of 3.2 to 3.8 W/cm for 120 seconds; the animals were sacrificed 3 hours after ablation for pathological examination. Photonic energy was delivered successfully to the ostium of five of the five targeted PVs, and was well tolerated hemodynamically in each animal without ectopy. Gross inspection revealed endocardial lesions at the ostium of four of five PVs, confined to the atrium in each and circumferential in three of five PVs. Microscopically, transmural coagulation necrosis of the atrium was present at the ostium of three of five PVs, and extended into the myocardial sleeves of two PVs. Photonic energy delivery using a fiberoptic balloon catheter can create circumferential lesions to the PV ostia, suggesting that this new form of energy delivery may be therapeutically advantageous for pulmonary vein ablation with need to pursue chronic studies.
authors.affiliation: Ottawa Heart Institute, 40 Ruskin St., Ottawa, Ontario, Canada K1Y 4W7. rlemery@ottawaheart.ca
authors.forename: Robert
authors.initials: R
authors.lastname: Lemery
authors.forename: John P
authors.initials: JP
authors.lastname: Veinot
authors.forename: Anthony S L
authors.initials: AS
authors.lastname: Tang
authors.forename: Martin
authors.initials: M
authors.lastname: Green
authors.forename: Norman
authors.initials: N
authors.lastname: Farr
authors.forename: Lincoln
authors.initials: L
authors.lastname: Baxter
authors.forename: Jon
authors.initials: J
authors.lastname: McIntyre
authors.forename: Ed
authors.initials: E
authors.lastname: Sinofsky
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000601:surgery; D017115:Catheter Ablation / Q000295:instrumentation*; D003287:Contrast Media; D017666:Deuterium Oxide; D005336:Fiber Optic Technology; D005471:Fluoroscopy; D006325:Heart Atria / Q000473:pathology* / Q000601:surgery; D053685:Laser Therapy / Q000379:methods*; D011667:Pulmonary Veins / Q000601:surgery*; D011677:Punctures; D013552:Swine
chemical_list: D003287:Contrast Media; D017666:Deuterium Oxide