T cell memory.
Typical immune responses lead to prominent clonal expansion of antigen-specific T and B cells followed by differentiation into effector cells. Most effector cells die at the end of the immune response but some of these cells survive and form long-lived memory cells. The factors controlling the formation and survival of memory T cells are reviewed.
Sprent
Jonathan
J
Department of Immunology, IMM4, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA. jsprent@scripps.edu
Surh
Charles D
CD
D000276:Adjuvants, Immunologic / Q000378:metabolism; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000941:Antigens / Q000378:metabolism; D017209:Apoptosis; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D016207:Cytokines / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000941:Antigens; D016207:Cytokines