title: Effect of electrode location in great cardiac vein on the ventricular defibrillation threshold.
abstract: This study tested the hypothesis that the DFT could be lowered by delivering a weak auxiliary shock in conjunction with a stronger primary shock with the auxiliary shock electrode near the cardiac region where the primary shock electric field is weakest. This hypothesis was tested by determining the DFTs with the auxiliary shock delivered from different locations within the great cardiac vein (GCV). In 15 dogs, catheters with defibrillation electrodes were placed transvenously in the RV apex, the SVC, and the GCV. An active can electrode and the SVC electrodes were electrically coupled to serve as a return electrode for the RV and GCV electrodes. DFTs were determined for a primary shock through the RV electrode with and without a subsequent auxiliary shock of lower amplitude through the GCV electrode. The leading edge voltage and current at DFT were significantly lowered by addition of the auxiliary shock (17% and 19% decreased, respectively), but energy was not changed. The animals were divided into three groups according to the location of the GCV electrode. The leading edge voltage, current, and total delivered energy at the DFT were significantly lower in animals with the GCV electrode near the apex (22%, 24%, and 13% reduction, respectively) compared with those where the GCV electrode was positioned away from apex (8%, 10% reduction and 18% increase, respectively, P < 0.001). Application of an auxiliary shock to the apical region, near the region where previous studies have indicated that the RV primary shock has its weakest effects, caused the greatest decrease in DFT.
authors.affiliation: Departments of Medicine, Biomedical Engineering and Physiology, University of Alabama at Birmingham, Birmingham, Alabama, USA. jh@crml.uab.edu
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Walcott
authors.forename: Cheryl R
authors.initials: CR
authors.lastname: Killingsworth
authors.forename: William M
authors.initials: WM
authors.lastname: Smith
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Kenknight
authors.forename: Raymond E
authors.initials: RE
authors.lastname: Ideker
mesh_terms: D000818:Animals; D002404:Catheterization; D003331:Coronary Vessels / Q000503:physiopathology*; D004056:Differential Threshold; D004285:Dogs; D004554:Electric Countershock; D004599:Electric Stimulation Therapy; D004566:Electrodes; D014693:Ventricular Fibrillation / Q000503:physiopathology*