title: Serial MRI findings in a case of primary lateral sclerosis.
abstract: A patient with primary lateral sclerosis (PLS) underwent MRI 3 times over 8.5 years. These images demonstrate progressive atrophy of the premotor, parietal, and primary sensorimotor cortex, with sparing of the temporal lobe, occipital lobe, and cerebellum. The pattern of cerebral atrophy was clearly restricted but was more extensive than expected from sensorimotor cortex pyramidal cell loss described in literature autopsy reports of PLS. Cortical motor system degeneration in PLS, whether primary or secondary, may be more extensive than previously believed.
authors.affiliation: Magnetic Resonance Imaging and Spectroscopy Center, Department of Neurology, University of Kentucky Medical Center, Lexington, KY 40536, USA. csmith@mri.uky.edu
authors.forename: Charles D
authors.initials: CD
authors.lastname: Smith
mesh_terms: D001284:Atrophy; D001921:Brain / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000473:pathology*