Syndrome of myelofibrosis and osteosclerosis: a series of case reports and review of the literature.
Myelofibrosis (MF) is a chronic disorder characterized by bone marrow evidence of myeloid metaplasia associated with reactive fibrosis, angiogenesis, and osteosclerosis. We report serum biochemistry, noninvasive markers of bone turnover, tetracycline-labeled bone histomorphometry, and bone densitometry (DXA) data of four men presenting with newly diagnosed biopsy-proven MF and osteosclerosis. The mechanisms and putative growth factors responsible for this syndrome are examined.
Diamond
T
T
Department of Endocrinology, St. George Hospital, University of New South Wales, Sydney, NSW, Australia. terryd@optushome.com.au
Smith
A
A
Schnier
R
R
Manoharan
A
A
D000368:Aged; D015519:Bone Density / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010026:Osteosclerosis / Q000378:metabolism / Q000473:pathology*; D055728:Primary Myelofibrosis / Q000378:metabolism / Q000473:pathology*; D013577:Syndrome