A multilateral effort to develop DNA vaccines against falciparum malaria.
Scientists from several organizations worldwide are working together to develop a multistage, multigene DNA-based vaccine against Plasmodium falciparum malaria. This collaborative vaccine development effort is named Multi-Stage DNA-based Malaria Vaccine Operation. An advisory board of international experts in vaccinology, malariology and field trials provides the scientific oversight to support the operation. This article discusses the rationale for the approach, underlying concepts and the pre-clinical development process, and provides a brief outline of the plans for the clinical testing of a multistage, multiantigen malaria vaccine based on DNA plasmid immunization technology.
Kumar
Sanjai
S
Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA. kumars@nmrc.navy.mil
Epstein
Judith E
JE
Richie
Thomas L
TL
Nkrumah
Francis K
FK
Soisson
Lorraine
L
Carucci
Daniel J
DJ
Hoffman
Stephen L
SL
D000818:Animals; D006801:Humans; D007391:International Cooperation; D017780:Malaria Vaccines / Q000008:administration & dosage* / Q000276:immunology; D016778:Malaria, Falciparum / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000276:immunology*; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000276:immunology
D017780:Malaria Vaccines; D019444:Vaccines, DNA