Developmental expression of cardiac myosin-binding protein C in Xenopus.
We have isolated the Xenopus homologue of cardiac myosin-binding protein C ( cMyBP-C) and describe its expression during early embryogenesis. cMyBP-C is expressed in both somites and heart at the time these tissues differentiate. Expression in the somites declines in older tadpoles. There is a high degree of conservation in residues where mutations causing hypertrophic cardiomyopathy have been identified in humans.
Duan
Li-Juan
LJ
Lawson Health Research Institute, 268 Grosvenor Street, Department of Paediatrics, University of Western Ontario, London, N6A 4V2, Canada.
George
Miranda E
ME
Drysdale
Thomas A
TA
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology; D008969:Molecular Sequence Data; D009154:Mutation; D019170:Somites / Q000378:metabolism*; D014982:Xenopus laevis / Q000196:embryology* / Q000235:genetics; D000099163:Myosin Binding Protein C
D002352:Carrier Proteins; D000099163:Myosin Binding Protein C