title: The onset of the excess of childhood cancer in Seascale, Cumbria.
abstract: BACKGROUND
  The objective of this study was to formally investigate the onset of the Seascale cluster of childhood and young person's cancer. This has not previously been attempted.
  
  
  METHODS
  A mortality study within the Whitehaven registration district was set up and death records were abstracted for 1906-1970. They were categorized as death from leukaemias, lymphomas, other cancers and all other causes in persons aged 0-14, 0-24 and 25-84. The number of deaths, death rates and standardized mortality ratios were calculated.
  
  
  RESULTS
  The mortality of persons aged 25-84 in Seascale civil parish, Gosforth civil parish and the rest of the Whitehaven district was unremarkable compared with national data 1906-1970. There were no cancer deaths aged 0-24 in Gosforth civil parish during 1906-1970. In Seascale civil parish a hitherto unrecorded childhood cancer case was revealed, dying in 1954. No cancer deaths aged 0-24 were found before that date. In the period 1946-1955 three cancer deaths gave a statistically significant excess owing to non-leukaemia cases, whereas in the period 1956-1965 a statistical excess of all types of leukaemia occurred as a result of two deaths. There was no case excess (based on one leukaemia death) in the period 1966-1970.
  
  
  CONCLUSIONS
  We found no clear temporal associations of the case excesses either with the periods of significant nuclear activity on the Sellafield site or with the main periods of population growth in the area.
authors.affiliation: Leukaemia Research Fund Centre for Clinical Epidemiology at the University of Leeds. P.A.Pickles@Leeds.ac.uk
authors.forename: R A
authors.initials: RA
authors.lastname: Cartwright
authors.forename: G J
authors.initials: GJ
authors.lastname: Dovey
authors.forename: E V
authors.initials: EV
authors.lastname: Kane
authors.forename: E A
authors.initials: EA
authors.lastname: Gilman
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D003644:Death Certificates; D004739:England / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000401:mortality; D007953:Leukemia, Radiation-Induced / Q000401:mortality; D008223:Lymphoma / Q000401:mortality; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology / Q000401:mortality*; D009381:Neoplasms, Radiation-Induced / Q000401:mortality; D011210:Power Plants; D011848:Radioactive Pollutants / Q000009:adverse effects*
chemical_list: D011848:Radioactive Pollutants