Effect of oxovanadium(IV) complexes on nondiabetic and streptozotocin-diabetic rats.
The effects of vanadium complexes with organic ligands, [VO(phen)2]SO4.3H2O, [VO(bpy)2]SO4.2H2O, and [VOCl2(Hmcp)2H2O], on blood glucose and plasma lipid levels were studied in nondiabetic and streptozotocin-diabetic rats and compared to that of [VO(mal)2] (the reference compound). The present results provide evidence that the compounds examined possess lower toxicity than [VO(mal)2]. One of the compounds examined, viz. [VO(bpy)2]SO4.2H2O, decreases, statistically significantly, the glucose level and a second one, viz. [VOCl2(Hmcp)2H2O], decreases, also significantly, the total cholesterol level.
Krosniak
M
M
Department of Food Chemistry and Nutrition, School of Medicine, Jagiellonian University, Medyczna 9, Kraków 30-688, Poland. mikrosni@cyf-kr.edu.pl
Zachwieja
Z
Z
Filipek
B
B
Zygmunt
M
M
Grybos
R
R
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D013329:Structure-Activity Relationship; D014638:Vanadates / Q000494:pharmacology* / Q000633:toxicity
D001786:Blood Glucose; D008055:Lipids; D009942:Organometallic Compounds; C075743:oxovanadium IV; D014638:Vanadates; D013311:Streptozocin