Antidiarrhoeal activity of Strychnos potatorum seed extract in rats.
The antidiarrhoeal activity of the methanol extract of the dried seeds of Strychnos potatorum (MESP) has been evaluated out in rats using different models (castor oil-induced diarrhoea, effects on gastrointestinal motility and on PGE(2)-induced gastric enteropooling. MESP (100, 200 and 400 mg/kg, p.o.) significantly (P<0.001) inhibited the frequency of defaecation and reduced the wetness of faecal droppings in castor oil-induced diarrhoea, decreased the propulsion of charcoal meal through the gastrointestinal tract, and also reduced the PGE(2)-induced enteropooling.
Biswas
Swati
S
Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadavpur University, Calcutta 700 032, India.
Murugesan
T
T
Sinha
Sanghamitra
S
Maiti
Kuntal
K
Gayen
Jiaur Rahaman
JR
Pal
M
M
Saha
B P
BP
D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003968:Diarrhea, Infantile / Q000188:drug therapy*; D015232:Dinoprostone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D029541:Loganiaceae; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds
D000930:Antidiarrheals; D010936:Plant Extracts; D015232:Dinoprostone