title: Development of new chiral building blocks for synthesis of bicyclo[3.3.0]octane compounds.
abstract: Ti(II)-mediated tandem cyclization of (E)-5-(tert-butyldimethylsilyloxy)-8-trimethylsilyl-2-octen-7-ynoate (7) prepared from commercially available optically active epichlorohydrin (2) proceeded diastereoselectively to provide 7-(tert-butyldimethylsilyloxy)-2-trimethylsilylbicyclo[3.3.0]oct-1-en-3-one (1), which serves as a useful chiral building block or intermediate to prepare a variety of compounds having a bicyclo[3.3.0]octane framework.
authors.affiliation: Department of Biomolecular Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho Midori-ku, Yokohama, Kanagawa 226-8501, Japan.
authors.forename: Kandasamy
authors.initials: K
authors.lastname: Subburaj
authors.forename: Sentaro
authors.initials: S
authors.lastname: Okamoto
authors.forename: Fumie
authors.initials: F
authors.lastname: Sato