Primary squamous cell carcinoma of the liver producing parathyroid hormone-related protein.
We report here an autopsy case of primary squamous cell carcinoma of the liver in a 63-year-old man who had hypercalcemia and an elevated serum level of parathyroid hormone-related protein. At autopsy, primary squamous cell carcinoma of the liver was found, without distinct preceding or associated hepatic or biliary diseases; no extrahepatic primary focus of squamous cell carcinoma was found. Bone involvement was not demonstrated, either radiologically or pathologically. Immunohistochemically, parathyroid hormone-related protein was detectable in the squamous cell carcinoma cells and it may have been responsible for the hypercalcemia. Such a case has not been reported so far in the English-language or the Japanese literature.
Saito
Takahito
T
Second Department of Pathology, Kanazawa University School of Medicine, Japan.
Harada
Kenichi
K
Tsuneyama
Koichi
K
Hirano
Masaaki
M
Amaya
Susumu
S
Sasaki
Motoko
M
Kaneko
Shuichi
S
Kobayashi
Kenichi
K
Nakanuma
Yasuni
Y
D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000175:diagnosis; D017809:Fatal Outcome; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000097:blood* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism*
C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins