Biotransformation of cadina-4,10(15)-dien-3-one and 3alpha-hydroxycadina-4,10(15)-diene by Curvularia lunata ATCC 12017.
Cadina-4,10(15)-dien-3-one (1) was metabolised by Curvularia lunata ATCC 12017 in two different growth media to give three metabolites, one of which, 12-hydroxycadina-4,10(15)-dien-3-one (4), was new. Incubation of 3alpha-hydroxycadina-4,10(15)-diene (2) with the fungus produced three new analogues, namely, (4S)-1alpha,3alpha-dihydroxycadin-10(15)-ene (5), 3alpha,14-dihydroxycadina-4,10(15)-diene (6) and 3alpha,12-dihydroxycadina-4,10(15)-diene (7).
Collins
Dwight O
DO
Department of Chemistry, University of the West Indies, Mona, Kingston 7, Jamaica.
Reese
Paul B
PB
D001203:Ascomycota / Q000378:metabolism*; D019686:Lamiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000493:pharmacokinetics*; D013056:Spectrophotometry, Ultraviolet
C454322:3-hydroxycadina-4,10(15)-diene; D009281:Naphthalenes; C096642:cadina-4,10(15)-dien-3-one