title: Methodology for estimation of time-dependent surface heat flux due to cryogen spray cooling.
abstract: Cryogen spray cooling (CSC) is an effective technique to protect the epidermis during cutaneous laser therapies. Spraying a cryogen onto the skin surface creates a time-varying heat flux, effectively cooling the skin during and following the cryogen spurt. In previous studies mathematical models were developed to predict the human skin temperature profiles during the cryogen spraying time. However, no studies have accounted for the additional cooling due to residual cryogen left on the skin surface following the spurt termination. We formulate and solve an inverse heat conduction (IHC) problem to predict the time-varying surface heat flux both during and following a cryogen spurt. The IHC formulation uses measured temperature profiles from within a medium to estimate the surface heat flux. We implement a one-dimensional sequential function specification method (SFSM) to estimate the surface heat flux from internal temperatures measured within an in vitro model in response to a cryogen spurt. Solution accuracy and experimental errors are examined using simulated temperature data. Heat flux following spurt termination appears substantial; however, it is less than that during the spraying time. The estimated time-varying heat flux can subsequently be used in forward heat conduction models to estimate temperature profiles in skin during and following a cryogen spurt and predict appropriate timing for onset of the laser pulse.
authors.affiliation: Department of Bioengineering, Rice University, Houston, TX 77251, USA.
authors.forename: James W
authors.initials: JW
authors.lastname: Tunnell
authors.forename: Jorge H
authors.initials: JH
authors.lastname: Torres
authors.forename: Bahman
authors.initials: B
authors.lastname: Anvari
mesh_terms: D000279:Administration, Cutaneous; D000335:Aerosol Propellants / Q000008:administration & dosage*; D000465:Algorithms; D003198:Computer Simulation; D017679:Cryotherapy / Q000379:methods*; D004853:Epoxy Resins; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000008:administration & dosage*; D053685:Laser Therapy / Q000379:methods; D008954:Models, Biological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012881:Skin Temperature / Q000187:drug effects* / Q000502:physiology; D013269:Stochastic Processes; D013499:Surface Properties; D013997:Time Factors; D004980:Ethane / Q000031:analogs & derivatives; D005466:Fluorocarbons
chemical_list: D000335:Aerosol Propellants; D004853:Epoxy Resins; D006845:Hydrocarbons, Fluorinated; C063006:norflurane; D004980:Ethane; D005466:Fluorocarbons