title: Assessment of a potential tumor-seeking manganese metalloporphyrin contrast agent in a mouse model.
abstract: The performance of a newly developed potential tumor-seeking magnetic resonance (MR) contrast agent alpha-Aqua-13,17-bis(1-carboxypropionyl) carbamoylethyl-3,8-bis(1-phenethyloxyethyl)-beta-hydroxy-2,7,12,18-tetramethyl-porphyrinato manganese (III) (HOP-8P) was tested using a mouse model. Tumor-bearing (SCC-VII) mice were imaged using a 1.5T MR imager before and after intravenous administration of 0.1 mmol/kg of HOP-8P. A biodistribution analysis was performed using an optical emission spectrometer. Significant enhancement of the transplanted tumor was observed in MR images 24 h after intravenous injection of HOP-8P. The biodistribution assessment of manganese also correlated with the results of the imaging study. During the 24-h period following contrast administration, HOP-8P was consistently cleared from the circulation, liver, kidneys, and muscle; however, it was progressively accumulated within the tumor. HOP-8P is a promising tumor-seeking metalloporphyrin MR contrast agent with a wide imaging window.
authors.affiliation: Department of Radiology, Hamamatsu University School of Medicine, Shizuoka, Japan. takehara@hama-med.ac.jp
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Takehara
authors.forename: Harumi
authors.initials: H
authors.lastname: Sakahara
authors.forename: Hatsuko
authors.initials: H
authors.lastname: Masunaga
authors.forename: Satoshi
authors.initials: S
authors.lastname: Isogai
authors.forename: Nami
authors.initials: N
authors.lastname: Kodaira
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sugiyama
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Takeda
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Saga
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakajima
authors.forename: Isao
authors.initials: I
authors.lastname: Sakata
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019786:Gadolinium DTPA / Q000008:administration & dosage / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008345:Manganese / Q000008:administration & dosage / Q000493:pharmacokinetics; D008665:Metalloporphyrins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental; D012878:Skin Neoplasms / Q000473:pathology*; D018709:Statistics, Nonparametric; D014018:Tissue Distribution
chemical_list: D003287:Contrast Media; C453639:HOP-8P; D008665:Metalloporphyrins; D008345:Manganese; D019786:Gadolinium DTPA