[Effect of perftoran on post-resuscitation recovery of the central nervous system].
The effect of perfluorane on survival and restorative process in the brain were studied in rats subjected to 12-min arrest of systemic circulation. Perfluorane in a single dose of 5-10 ml/kg was injected intraperitoneally 30 min after the beginning of reanimation. The drug did not affect the postreanimation death of animals and time course of neurologic deficiency disappearance. Perfluorane activated behavioral reactions and prevented development of dystrophic changes in the brain structures of rats highly sensitive to hypoxia.
Volkov
A V
AV
Avrushchenko
M Sh
MSh
Zarzhetskiĭ
Iu V
IuV
Nazarenko
I V
IV
Mutuskina
E A
EA
Trubina
I E
IE
Samorukova
I V
IV
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D005466:Fluorocarbons / Q000494:pharmacology*; D000860:Hypoxia; D051381:Rats; D012151:Resuscitation
D005466:Fluorocarbons; C063334:perftoran