[Study of C807T polymorphism of the platelet collagen receptor alpha2 gene coding sequence in Suzhou Han population].
OBJECTIVE
To study the C807T polymorphism of the platelet collagen receptor alpha(2) gene coding sequence in Suzhou Han population. This polymorphism was associated with the expression density of integrin alpha(2)beta(1) on the platelet surface.


METHODS
An amplified 1332 bp fragment of human alpha(2) gene from 110 unrelated individuals was analyzed by Bgl II and Ase I restriction assay. The resulting products were electrophoresed in 8% polyacrylamide gels and stained with ethidium bromide.


RESULTS
The allelic frequencies were 0.291:0.709 for T807 allele: C807 allele in Suzhou Han population. The total theoretical heterozygous rate was 41%. The genotypic frequencies were 0.018:0.546:0.436 for homozygous 807T allele: heterozygous 807C/T allele: homozygous 807C allele.


CONCLUSIONS
The C807T polymorphism of the platelet collagen receptor alpha2 gene in Suzhou Han population was different from that observed in other populations.
Shi
J
J
Thrombosis and Hemostasis Research Unit, Jiangsu Institute of Hematology, The First Affiliated Hospital, Suzhou University, Suzhou 215006, China.
Gao
W
W
Bai
X
X
Wang
Z
Z
Ruan
C
C
D044466:Asian People / Q000208:ethnology* / Q000235:genetics*; D002681:China; D005260:Female; D006801:Humans; D038982:Integrin alpha2beta1 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide
D038982:Integrin alpha2beta1