[Synthesis and antibacterial activity of the new 9-aminoacridine, 10,11-dihydro-5H-dibenzo[b,f]azepine, polyfluoro 5,6-dihydro-1,3,5-oxadiazine derivatives].
Screening among 9-aminoacridine, 10,11-dihydro-5H-dibenz[b, f]azepine and polyfluoro 5,6-dihydro-1,3,5-oxadiazine derivatives allowed to isolate compounds with potential antibacterial activity. Schemes of the active compounds synthesis are given. The most important is the estimation of the oxydiazines activity against gram-positive microorganisms including methicillin-resistant staphylococci. Special attention is paid to the activity of iminodibenzyl derivatives against multiresistant gram-negative microorganisms.
Torgun
I N
IN
Center of Medical, Biological and Ecological Problems, Russian Academy of Natural Sciences, National Research Centre of Antibiotics, Moscow.
Sydorenko
S V
SV
Zykova
I E
IE
Iudin
S M
SM
Kriukova
L I
LI
Krylov
I I
II
Kriukov
L N
LN
Kuznotsov
S L
SL
Vorontsov
E A
EA
Rezvan
S P
SP
Grudinina
S A
SA
D000585:Aminacrine / Q000737:chemistry / Q000494:pharmacology; D000609:Aminoacridines / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001381:Azepines / Q000737:chemistry; D001671:Biochemistry / Q000379:methods; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006094:Gram-Positive Bacteria / Q000187:drug effects; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010078:Oxazines / Q000737:chemistry; D013210:Staphylococcus / Q000187:drug effects / Q000502:physiology
C453540:9-ethyltrifluoromethylmalonylamidoacridine; D000609:Aminoacridines; D000900:Anti-Bacterial Agents; D001381:Azepines; D010078:Oxazines; D000585:Aminacrine