Differential effect of walnut oil and safflower oil on the serum cholesterol level and lesion area in the aortic root of apolipoprotein E-deficient mice.
Walnut oil (WO) is a good source of alpha-linolenic acid. We compared the effects of WO and high-linoleic safflower oil (HLSO) on the serum lipid level and atherosclerosis development in male and female apolipoprotein (apo) E-deficient mice. The WO diet resulted in a higher level of serum cholesterol than with HLSO. Female mice fed on the WO diet had a greater lesion area in the aortic root than did those on the HLSO diet. There was no diet-dependent difference in the level of cholesterol and its oxidation products in the abdominal and thoracic aorta. These results suggest that the unpleasant effects of the WO diet on apo E-deficient mice may be attributable to alpha-linolenic acid.
Iwamoto
Masako
M
Laboratory of Nutrition Chemistry, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.
Kono
Misaki
M
Kawamoto
Daisuke
D
Tomoyori
Hiroko
H
Sato
Masao
M
Imaizumi
Katsumi
K
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D001161:Arteriosclerosis / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D002784:Cholesterol / Q000097:blood*; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006128:Growth; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D010084:Oxidation-Reduction; D010938:Plant Oils / Q000494:pharmacology*; D012450:Safflower Oil / Q000494:pharmacology*
D001057:Apolipoproteins E; D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D008055:Lipids; D010938:Plant Oils; D012450:Safflower Oil; D002784:Cholesterol