title: Peri-implant tissue response of immediately loaded, threaded, HA-coated implants: 1-year results.
abstract: BACKGROUND
  Although high success rates have been reported with immediately loaded implants, the peri-implant tissue response has not been well documented.
  
  
  OBJECTIVE
  This study evaluated implant success and peri-implant tissue response of immediately loaded, threaded, hydroxyapatite (HA)-coated root-form implants supporting mandibular bar overdentures with opposing conventional maxillary complete dentures in humans.
  
  
  METHODS
  Five patients (3 men, 2 women; mean age 61 years) each received 4 HA-coated endosseous root-form implants in the interforaminal region in the mandible. The implants were rigidly splinted with a metal framework within 24 hours. The final EDS clip prosthesis was placed 1 to 2 weeks thereafter. The implants and peri-implant tissues were evaluated clinically and radiographically 0, 1, 3, 6, and 12 months after prosthesis placement. Data were analyzed with a repeated measures 1-way analysis of variance (P<.05).
  
  
  RESULTS
  All implants were stable at the end of the observation period (mean Periotest value = -5.9 +/- 1.4). No peri-implant radiolucencies were noted, and no implants were lost. The mean marginal bone changes were -0.42 plus minus 0.34, -0.84 +/- 0.55, -1.14 +/- 0.80, and -1.16 +/- 0.89 mm at the 1-, 3-, 6-, and 12-month follow-ups, respectively (P<.001). Significant declines in the rates of marginal bone changes at each time interval were noted (P<.001). In addition, there were significant decreases in probing depth (P<.001) and plaque index (P<.001) but no significant difference in the frequency of bleeding upon probing (P=.64).
  
  
  CONCLUSIONS
  Within the limitations of this study, the peri-implant tissue response of immediately loaded, HA-coated implants was favorable and comparable to that of conventional, delayed-loaded implants after 1 year.
authors.affiliation: Department of Restorative Dentistry, School of Dentistry, Loma Linda University, Loma Linda, CA 92350, USA. rungkit@hotmail.com
authors.forename: Kitichai
authors.initials: K
authors.lastname: Rungcharassaeng
authors.forename: Jaime L
authors.initials: JL
authors.lastname: Lozada
authors.forename: Joseph Y k
authors.initials: JY
authors.lastname: Kan
authors.forename: Jay S
authors.initials: JS
authors.lastname: Kim
authors.forename: Wayne V
authors.initials: WV
authors.lastname: Campagni
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Munoz
mesh_terms: D000368:Aged; D016301:Alveolar Bone Loss / Q000209:etiology; D000704:Analysis of Variance; D020099:Coated Materials, Biocompatible; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants / Q000009:adverse effects; D017267:Dental Prosthesis Design; D017268:Dental Prosthesis Retention / Q000295:instrumentation; D019094:Dental Prosthesis, Implant-Supported; D019232:Dental Restoration Failure; D003825:Denture, Complete, Immediate; D003828:Denture, Overlay; D017886:Durapatite; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D017886:Durapatite