Piracetam for fetal distress in labour.
BACKGROUND
Piracetam is thought to promote the metabolism of brain cells when they are hypoxic. It has been used to prevent adverse effects of fetal distress.


OBJECTIVE
The objective of this review was to assess the effects of piracetam for suspected fetal distress in labour on method of delivery and perinatal morbidity.


METHODS
The Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register (The Cochrane Library Issue 3, 2001) were searched. Date of last search: September 2001.


METHODS
Randomised trials of piracetam compared with placebo or no treatment for suspected fetal distress in labour.


METHODS
Both reviewers assessed eligibility and trial quality.


RESULTS
One study of 96 women was included. Piracetam compared with placebo was associated with a trend to reduced need for caesarean section (relative risk 0.57, 95% confidence interval 0.32 to 1.03). There were no statistically significant differences in relative risk between the piracetam and placebo group for neonatal morbidity (measured by neonatal respiratory distress) or Apgar score.


CONCLUSIONS
There is not enough evidence to evaluate the use of piracetam for fetal distress in labour.
Hofmeyr
G J
GJ
Effective Care Research Unit, University of the Witwatersrand, Frere/Cecilia Makiwane Hospitals, Private Bag 9047, East London 5200, Eastern Cape, South Africa. gjh@global.co.za
Kulier
R
R
D036861:Delivery, Obstetric; D005260:Female; D005316:Fetal Distress / Q000188:drug therapy*; D006801:Humans; D007743:Labor, Obstetric; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010889:Piracetam / Q000627:therapeutic use*; D011247:Pregnancy
D018696:Neuroprotective Agents; D010889:Piracetam