title: Pancreatic duct: morphologic evaluation with MR cholangiopancreatography after secretin stimulation.
abstract: OBJECTIVE
  To evaluate the pancreatic duct after administration of secretin.
  
  
  METHODS
  Single-shot turbo spin-echo T2-weighted dynamic magnetic resonance cholangiopancreatography (MRCP) was performed in 85 patients who did not have pancreatic diseases (group 1) and in 50 patients who had focal severe stenosis of the main pancreatic duct (group 2). The visualization and diameter of the pancreatic duct before and after secretin administration were assessed.
  
  
  RESULTS
  In group 1, after secretin administration, the best visualization of the main pancreatic duct in the head, body, accessory pancreatic duct, and branch ducts was achieved in 4.7 minutes +/- 1.6 (SD), 4.8 minutes +/- 1.6, 4.6 minutes +/- 1.6, and 4.7 minutes plus minus 1.3, respectively. Improvement in the delineation of the main pancreatic duct in the head (78 [92%] patients), body (80 [94%] patients), accessory pancreatic duct (35 [41%] patients), and branch ducts (14 [16%] patients) was achieved. Overlap of fluid in the organ and the pancreatic duct was observed in 20 (24%) of 85 patients. Overlap was especially observed after 5 minutes of secretin injection. In group 2, the best visualization of the distal main pancreatic duct was achieved 4.9 minutes +/- 1.4 after secretin administration. Improvement in the delineation of the distal main pancreatic duct was achieved in 17 (85%) of 20 patients.
  
  
  CONCLUSIONS
  MRCP is best performed during the first 5 minutes after secretin administration.
authors.affiliation: Department of Radiology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima-shi 890-8520, Japan. fukukura@m.kufm.kagosmhima-u.ac.jp
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Fukukura
authors.forename: Fumito
authors.initials: F
authors.lastname: Fujiyoshi
authors.forename: Michiro
authors.initials: M
authors.lastname: Sasaki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakajo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003251:Constriction, Pathologic; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism; D010183:Pancreatic Ducts / Q000033:anatomy & histology / Q000187:drug effects / Q000473:pathology*; D012189:Retrospective Studies; D012633:Secretin / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D012633:Secretin