title: Role of Purkinje conducting system in triggering of idiopathic ventricular fibrillation.
abstract: Ventricular fibrillation is the main mechanism of sudden cardiac death, but the source of its spontaneous initiation has not been mapped. 16 patients were investigated by electrography and radiofrequency ablation after resuscitation from recurrent idiopathic ventricular fibrillation. Triggers of ventricular fibrillation originated from various locations within the Purkinje system in 12 patients and from the ordinary myocardial muscle in four. The accuracy of mapping was confirmed by acute elimination of triggers by radiofrequency delivery, and there was no recurrence of ventricular fibrillation in 14 patients. Long-term follow-up is necessary to establish that ablation is curative and avoids use of a defibrillator.
authors.affiliation: Hôpital Cardiologique du Haut-Lévêque, Bordeaux-Pessac, France. jacques.clementy@pu.u-bordeaux.fr
authors.forename: Michel
authors.initials: M
authors.lastname: Haïssaguerre
authors.forename: Dipen C
authors.initials: DC
authors.lastname: Shah
authors.forename: Pierre
authors.initials: P
authors.lastname: Jaïs
authors.forename: Morio
authors.initials: M
authors.lastname: Shoda
authors.forename: Josef
authors.initials: J
authors.lastname: Kautzner
authors.forename: Thomas
authors.initials: T
authors.lastname: Arentz
authors.forename: Dietrich
authors.initials: D
authors.lastname: Kalushe
authors.forename: Alan
authors.initials: A
authors.lastname: Kadish
authors.forename: Mike
authors.initials: M
authors.lastname: Griffith
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Gaïta
authors.forename: Teiichi
authors.initials: T
authors.lastname: Yamane
authors.forename: Stephane
authors.initials: S
authors.lastname: Garrigue
authors.forename: Meleze
authors.initials: M
authors.lastname: Hocini
authors.forename: Jacques
authors.initials: J
authors.lastname: Clémenty
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017115:Catheter Ablation; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011690:Purkinje Fibers / Q000502:physiology*; D014693:Ventricular Fibrillation / Q000503:physiopathology* / Q000628:therapy