title: [Synchronous tumor of the upper urinary tract with bladder cancer. Opportunity for nephroureterectomy and block-cystectomy].
abstract: OBJECTIVE
  One of the basic characteristics of urothelial carcinoma is its tendency to synchronous or metachronous multifocality. Thus the need to explore the entire urinary tract of patients with urothelial neoformations. The aim of this article is to study the tumors of the upper urinary tract that appear synchronously with infiltrating carcinoma of the bladder. The clinicopathological characteristics and the morbidity and mortality of en bloc surgery of both tumors are analyzed.
  
  
  METHODS
  A retrospective study was carried out on 170 radical cystectomies for infiltrating bladder tumor performed in our department over a 13-year period. Patient history, clinicopathological characteristics, complementary tests, type of surgery performed, postoperative complications and follow-up were analyzed.
  
  
  RESULTS
  Tumor of the upper urinary tract appeared in 14 (1 bilateral) of these patients and were synchronous in 10 cases. All patients were male; mean age 63 years. Three were localized in the pelvis, 2 in the proximal ureter and 6 in the distal third. Diagnosis was made by IVP in 6 patients and by US and antegrade pyelography in the other 4 patients. Nephroureterectomy and radical cystectomy were performed en bloc in 8 cases; 6 had a Bricker procedure and 2 ileal substitution. Salvage radical cystectomy + distal ureterectomy were performed in the other two patients. Two patients submitted to en bloc surgery had postoperative complications; one presented prolonged ileua and the other required surgery for retroperitoneal hemorrhage. The two patients submitted to palliative surgery died of and sepsis during the postoperative period. At 33 months' mean follow-up, 3 patients have shown tumor progression.
  
  
  CONCLUSIONS
  There is a high proportion of synchronous tumor of the upper urinary tract in our series of patients with infiltrating carcinoma of the bladder undergoing radical cystectomy, therefore we consider it necessary to explore the entire urinary system. Surgical removal of both tumors en bloc does not increase the morbidity and mortality.
authors.affiliation: Servicio de Urología, Hospital General Universitario, Murcia, España.
authors.forename: J
authors.initials: J
authors.lastname: Navas Pastor
authors.forename: J
authors.initials: J
authors.lastname: García Ligero
authors.forename: F
authors.initials: F
authors.lastname: García García
authors.forename: M
authors.initials: M
authors.lastname: Tomás Ros
authors.forename: J L
authors.initials: JL
authors.lastname: Rico Galiano
authors.forename: A
authors.initials: A
authors.lastname: Sempere Gutiérrez
authors.forename: J
authors.initials: J
authors.lastname: Gil Franco
authors.forename: L O
authors.initials: LO
authors.lastname: Fontana Compiano
mesh_terms: D000368:Aged; D015653:Cystectomy / Q000379:methods*; D006801:Humans; D007432:Intraoperative Period; D007680:Kidney Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000601:surgery*; D009392:Nephrectomy / Q000379:methods*; D012189:Retrospective Studies; D014516:Ureteral Neoplasms / Q000601:surgery*; D001749:Urinary Bladder Neoplasms / Q000601:surgery*