title: Cytotoxic-antineoplastic activity of hydroquinone derivatives.
abstract: Several myrcenylhydroquinone derivatives have been evaluated for their cytotoxic activity against three neoplastic cell line cultures and compared with the activity previously observed on other neoplastic systems. Also a new series of this type of compounds has been prepared and the compounds synthesised have been evaluated by their GI(50) values.
authors.affiliation: Instituto de Química, Universidad Católica de Valparaíso, Casilla 4059, Valparaíso, Chile. amolinar@ucv.cl
authors.forename: Aurora
authors.initials: A
authors.lastname: Molinari
authors.forename: Alfonso
authors.initials: A
authors.lastname: Oliva
authors.forename: Paola
authors.initials: P
authors.lastname: Reinoso
authors.forename: Jose M  Miguel
authors.initials: JM
authors.lastname: del Corral
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Castro
authors.forename: Marina
authors.initials: M
authors.lastname: Gordaliza
authors.forename: Mahabir P
authors.initials: MP
authors.lastname: Gupta
authors.forename: Pablo
authors.initials: P
authors.lastname: Solís
authors.forename: Arturo
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006873:Hydroquinones