title: [Apoptosis as a measure of chemosensitivity to anti-cancer drugs in gynecological cancer].
abstract: OBJECTIVE
  To examine apoptosis as a measure of chemosensitivity to anti-cancer drugs in gynecological cancer xenografted into nude mice.
  
  
  METHODS
  The TUNEL method was used to investigate the induction of apoptosis after exposure to anti-cancer drugs in thirteen gynecological cancers xenografted into nude mice. Moreover, in vivo sensitivities of gynecologic cancer to anti-cancer drugs were determined according to the protocol developed by Battle Laboratories, Columbus, Ohio USA. Both methods were examined for correlation.
  
  
  RESULTS
  The apoptosis index by the TUNEL method showed a correlation with the findings using the protocol developed by Battle Laboratories, Columbus, Ohio USA.
  
  
  CONCLUSIONS
  Our findings indicate the ability to determine the measure of chemosensitivity by the apoptosis index.
authors.affiliation: Dept. of Obstetrics and Gynecology, Tonami General Hospital.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fushiki
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Yuuki
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Nakashima
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujimura
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
authors.forename: Rikuichi
authors.initials: R
authors.lastname: Izumi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002945:Cisplatin / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D020287:In Situ Nick-End Labeling; D000077146:Irinotecan; D051379:Mice; D008819:Mice, Nude; D016685:Mitomycin / Q000494:pharmacology; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000473:pathology*; D017239:Paclitaxel / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014594:Uterine Neoplasms / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D016685:Mitomycin; D000077146:Irinotecan; D017239:Paclitaxel; D002945:Cisplatin; D002166:Camptothecin