title: Optimal management of septic shock. Rapid recognition and institution of therapy are crucial.
abstract: Septic shock is a common problem in hospitalized patients. Optimal management depends on rapid recognition, aggressive restoration of circulating volume with fluid boluses, initiation of appropriate antibiotic therapy, implementation of adequate monitoring, and meticulous attention to the details of care. Mean arterial pressure should be increased to between 65 and 75 mm Hg as soon as possible to reduce the likelihood of multiorgan dysfunction. Despite these therapeutic maneuvers, however, mortality rates are likely to remain high until the development of therapies that better target the underlying mechanisms of sepsis.
authors.affiliation: Multidisciplinary Intensive Care Unit, Section of Pulmonary and Critical Care Medicine, Department of Medicine, Medical College of Georgia School of Medicine, BBR-5513, 1120 15th St, Augusta, GA 30912-3135, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Fitch
authors.forename: James R
authors.initials: JR
authors.lastname: Gossage
mesh_terms: D000140:Acidosis, Lactic / Q000517:prevention & control; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002316:Cardiotonic Agents / Q000627:therapeutic use; D002407:Catheterization, Swan-Ganz; D005440:Fluid Therapy; D006439:Hemodynamics; D006801:Humans; D012772:Shock, Septic / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents; D002316:Cardiotonic Agents