title: Juvenile rheumatoid arthritis with amyloid goiter: report of a case with review of the literature.
abstract: Clinically significant enlargement of the thyroid owing to amyloid deposition is a rare occurrence. A 23-yr-old female, a case of juvenile rheumatoid arthritis, developed rapidly increasing thyromegaly during the course of her illness with complaints of dyspnea and dysphagia. Thyroid function tests were within normal limits. Fine-needle aspiration cytology proved inconclusive. Total thyroidectomy was done for symptomatic relief with a preoperative clinical impression of malignancy. Histopathologic findings were consistent with amyloid goiter. The findings of this case are presented, to emphasize the difficulties in making a definite preoperative diagnosis, along with a brief review of the literature.
authors.affiliation: Department of Pathology, New England Medical Center, 750 Washington Street, Boston, MA 02111, USA. E-mail: ASrivastava@Lifespan.org
authors.forename: A
authors.initials: A
authors.lastname: Srivastava
authors.forename: M
authors.initials: M
authors.lastname: Baxi
authors.forename: S
authors.initials: S
authors.lastname: Yadav
authors.forename: A
authors.initials: A
authors.lastname: Agarwal
authors.forename: R K
authors.initials: RK
authors.lastname: Gupta
authors.forename: S K
authors.initials: SK
authors.lastname: Misra
authors.forename: A
authors.initials: A
authors.lastname: Mithal
mesh_terms: D000328:Adult; D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D001171:Arthritis, Juvenile / Q000150:complications* / Q000473:pathology; D005260:Female; D006044:Goiter, Nodular / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D014057:Tomography, X-Ray Computed
chemical_list: D000682:Amyloid