title: Successful clot lysis using low dose of streptokinase in 22 neonates with aortic thromboses.
abstract: OBJECTIVE
  To determine whether intravenous infusion of low dose of streptokinase was effective in lysing umbilical arterial catheter (UAC)-associated aortic thrombi.
  
  
  METHODS
  A prospective cohort study of 31 consecutive newborn infants with UAC-associated aortic thrombi which were detected by abdominal ultrasonography after removal of UAC. Twenty-two infants were treated with intravenous infusion of low dose (1000 U/h) streptokinase, while nine others were not treated due to various contra-indications. Thrombolysis occurred after a mean interval of 2.2 days (standard deviation (SD) = 1.8) in the treated infants. In the untreated infants, spontaneous thrombolysis occurred significantly later, after a mean interval of 16.9 days (SD = 14.7) (95% confidence intervals of difference between mean intervals - 26.0, - 3.4; P = 0.02). Only one treated infant developed mild bleeding directly attributed to streptokinase therapy.
  
  
  CONCLUSIONS
  Low dose streptokinase infusion was effective and safe in thrombolysing UAC-associated aortic thrombi.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Kuala Lumpur.
authors.forename: F C
authors.initials: FC
authors.lastname: Cheah
authors.forename: N Y
authors.initials: NY
authors.lastname: Boo
authors.forename: J
authors.initials: J
authors.lastname: Rohana
authors.forename: S C
authors.initials: SC
authors.lastname: Yong
mesh_terms: D001018:Aortic Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D002404:Catheterization / Q000009:adverse effects; D015331:Cohort Studies; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D010960:Plasminogen Activators / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D013300:Streptokinase / Q000008:administration & dosage / Q000627:therapeutic use*; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D014463:Ultrasonography; D014469:Umbilical Arteries
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase; D010960:Plasminogen Activators