Effects of endosulfan on intestinal functions in protein-malnourished rats.
In rats fed 18% protein diet, administration of endosulfan (2mg/kg body weight daily for 7 days) significantly decreased the brush border sialic acid and increased the hexoses contents. The intestinal uptake of glucose was increased while that of glycine and calcium was reduced. Brush border enzymes and lipids were not affected. However, in protein malnourished rats (fed 8% protein) exposed to endosulfan, brush border sucrase and peptidase activities were enhanced, while alkaline phosphatase activity was decreased compared to untreated malnourished animals. Membrane sialic acid content was low while fucose and cholesterol levels were augmented in endosulfan fed malnourished animals. The uptake of glucose and glycine was elevated under these conditions. These results Suggest that the nutritional status of the animals has an important bearing on thc susceptibility of intestinal tissue to endosulfan toxicity in rats.
Labana
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Department of Biochemistry, Panjab University, Chandigarh, India. akhtarmah@yahoo.com
Bansal
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Mahmood
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D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage / Q000097:blood; D004726:Endosulfan / Q000633:toxicity*; D005947:Glucose / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000633:toxicity*; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D008871:Microvilli / Q000187:drug effects / Q000378:metabolism; D009748:Nutrition Disorders / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004044:Dietary Proteins; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D007930:Leucine; D005947:Glucose; D004726:Endosulfan; D002118:Calcium; D005998:Glycine