title: Multiple sebaceous adenomas and extraocular sebaceous carcinoma in a patient with multiple sclerosis: case report and review of literature.
abstract: BACKGROUND
  Sebaceous carcinomas are relatively rare cutaneous tumors; there are fewer than 600 cases reported. They most commonly arise within the meibomian gland of the eyelid; fewer than 150 of the reported cases were extraocular. These tumors have a high incidence of local recurrence and regional metastasis. The relationship of sebaceous tumors and visceral malignancy is well established in the literature.
  
  
  OBJECTIVE
  We describe a 44-year-old white female with chronic progressive multiple sclerosis who developed multiple scalp sebaceous adenomas and a solitary sebaceous carcinoma.
  
  
  CONCLUSIONS
  Extraocular sebaceous carcinomas are rare tumors with high incidence of local recurrence and regional metastasis. Surgery with wide surgical margins is the standard treatment. We report the first case of multiple sebaceous tumors in a patient with multiple sclerosis. The presence of sebaceous tumors warrants a search for an internal malignancy. Literature on sebaceous tumors and their relationship with visceral malignancies and immunologic disorders is discussed. Literature on sebaceous carcinoma with special attention to extraocular sebaceous carcinoma is also discussed.
authors.affiliation: Division of Hematologic Malignancies, Johns Hopkins Oncology Center, Baltimore, MD, USA. akhtars18@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Akhtar
authors.forename: K K
authors.initials: KK
authors.lastname: Oza
authors.forename: R G
authors.initials: RG
authors.lastname: Roulier
mesh_terms: D018266:Adenocarcinoma, Sebaceous / Q000150:complications* / Q000473:pathology; D000236:Adenoma / Q000150:complications* / Q000473:pathology; D000328:Adult; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000473:pathology; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012535:Scalp; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology