title: Phentolamine mesylate in postmenopausal women with female sexual arousal disorder: a psychophysiological study.
abstract: The objective of this study was to assess the potential of phentolamine as a treatment of postmenopausal women with female arousal disorder (FSAD). Vaginal photoplethismography and a subjective questionnaire were used. Forty one women were enrolled and four treatments were tested: vaginal solutions 5 mg and 40 mg and an oral tablet each of 40 mg of phentolamine and placebo. Physiological readings were significantly different from placebo in the women using hormone replacement therapy (HRT) with 40 mg of phentolamine in vaginal solution (p = 0.0186). Subjective reports also were significantly different from placebo with the vaginal solution 40 mg and the oral tablet of 40 mg of phentolamine among hormone replacement users. No significant differences were found among women not receiving HRT. Results indicate that phentolamine may show promise as treatment for FSAD in estrogenized postmenopausal women.
authors.affiliation: Asociación Mexicana para la Salud Sexual, AC Tezoquipa 26, Colonia la Joya, Delegacion Tlalpan, Mexico DF 1400. eusebio@internet.com.mx
authors.forename: Eusebio
authors.initials: E
authors.lastname: Rubio-Aurioles
authors.forename: Marcela
authors.initials: M
authors.lastname: Lopez
authors.forename: Mirtha
authors.initials: M
authors.lastname: Lipezker
authors.forename: Claudia
authors.initials: C
authors.lastname: Lara
authors.forename: Abraham
authors.initials: A
authors.lastname: Ramírez
authors.forename: Claudia
authors.initials: C
authors.lastname: Rampazzo
authors.forename: María T
authors.initials: MT
authors.lastname: Hurtado de Mendoza
authors.forename: Fred
authors.initials: F
authors.lastname: Lowrey
authors.forename: Lean A
authors.initials: LA
authors.lastname: Loehr
authors.forename: Paul
authors.initials: P
authors.lastname: Lammers
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D010646:Phentolamine / Q000494:pharmacology*; D017156:Photoplethysmography / Q000295:instrumentation; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy*; D014621:Vagina / Q000098:blood supply
chemical_list: D000317:Adrenergic alpha-Antagonists; D010646:Phentolamine