Insulin-like growth factor-I: compartmentalization within the somatotropic axis?
Insulin-like growth factor-I (IGF-I) is essential for normal growth; igf-1 gene mutations are associated with extreme growth retardation in mice and, very rarely, in humans. The relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question. New gene targeting technologies are providing answers for these questions.
Butler
Andrew A
AA
The Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA.
Yakar
Shoshana
S
LeRoith
Derek
D
D000818:Animals; D006128:Growth / Q000502:physiology*; D006130:Growth Disorders / Q000503:physiopathology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D008099:Liver / Q000502:physiology
D007334:Insulin-Like Growth Factor I