title: Multidrug resistance mechanisms in chronic lymphocytic leukaemia.
abstract: We evaluated the presence of P-glycoprotein (P-gp)-170, multidrug resistance protein (MRP), lung resistance protein (LRP)-56 and Bcl-2 in CD19-positive cells from 100 cases of chronic lymphocytic leukaemia (CLL). P-gp-170 was found in 73% of the CLL cases with no significant difference regarding stage or previous treatment. LRP-56 protein was homogeneously distributed with no differences for stage or treatment. MRP protein was detected at a low level of expression in 49.4% of CLL patients with no differences for stage or treatment. Bcl-2 protein was expressed at a high level in all CLL patients and higher levels were found in the advanced stage. This leads us to conclude that P-gp, MRP, LRP-56 and Bcl-2 are frequently expressed in CLL. P-gp, MRP and LRP are not correlated to stage or previous treatment. Bcl-2 is higher in advanced-stage patients. The clinical and biological significance of these zMDR mechanisms in CLL remains to be fully explained.
authors.affiliation: Division of Haematology with Bone Marrow Transplantation, University of Catania, Italy. ugo.consoli@tin.it
authors.forename: Ugo
authors.initials: U
authors.lastname: Consoli
authors.forename: AnnaMaria
authors.initials: A
authors.lastname: Santonocito
authors.forename: Fabio
authors.initials: F
authors.lastname: Stagno
authors.forename: Paolo
authors.initials: P
authors.lastname: Fiumara
authors.forename: Antonella
authors.initials: A
authors.lastname: Privitera
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Parisi
authors.forename: Giada M
authors.initials: GM
authors.lastname: Giustolisi
authors.forename: Biagia
authors.initials: B
authors.lastname: Pavone
authors.forename: Giuseppe A
authors.initials: GA
authors.lastname: Palumbo
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Raimondo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Milone
authors.forename: Patrizia
authors.initials: P
authors.lastname: Guglielmo
authors.forename: Rosario
authors.initials: R
authors.lastname: Giustolisi
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis; D018941:Antigens, CD19; D018432:Drug Resistance, Multiple; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000378:metabolism*; D008214:Lymphocytes / Q000737:chemistry; D009363:Neoplasm Proteins / Q000032:analysis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D020394:Vault Ribonucleoprotein Particles; D000099187:Major Vault Protein
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018941:Antigens, CD19; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D020394:Vault Ribonucleoprotein Particles; D000099187:Major Vault Protein