title: [Three cases with a mediastinal neurinoma developed in a same family].
abstract: A 47-years-old woman (case 1) was admitted to our hospital because of a mediastinal mass. We performed an operation by VATS under the diagnosis of a mediastinal neurinoma. The histology of it was a neurinoma. Her father (case 2) had undergone a resection of a mediastinal neurinoma at the age of 42. Her brother (case 3) also had undergone a resection of mediastinal and intrathoracic neurinomas at the age of 37. A few years later, he underwent operations for neurinomas in limbs 2 times. We suppose patients with a mediastinal neurinoma have little complaints in many cases, so there are a number of patients who have a mediastinal neurinoma without being discovered and treated. Although the neurinoma is not considered as a hereditary disease inherently, the cases, we experienced, might have some genetic disorders. In this concern, our cases are very rare and have a great interest.
authors.affiliation: Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Harada
authors.forename: H
authors.initials: H
authors.lastname: Matsuoka
authors.forename: W
authors.initials: W
authors.lastname: Nishio
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: T
authors.initials: T
authors.lastname: Yuki
authors.forename: N
authors.initials: N
authors.lastname: Tsubota
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery*; D008875:Middle Aged; D009442:Neurilemmoma / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery*; D012086:Reoperation; D020775:Thoracic Surgery, Video-Assisted