Muscle differentiation: how two cells become one.
A key feature of myogenesis is the fusion of myoblasts to form multinucleate myotubes. Recent work in Drosophila has uncovered a collection of genes that operate at different stages of this process. Some interactions between them have been described that begin to define links from outside the cell via the plasma membrane to the cytoskeleton. Future studies will establish the extent to which the molecular mechanisms of myoblast fusion are conserved between Drosophila and other animals, as found in other aspects of myogenesis.
Taylor
Michael V
MV
Cardiff School of Biosciences, Cardiff University, UK. TaylorMV@cf.ac.uk
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002459:Cell Fusion; D002462:Cell Membrane / Q000235:genetics / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004625:Embryo, Nonmammalian; D018507:Gene Expression Regulation, Developmental; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins; D008648:Mesoderm; D009124:Muscle Proteins; D009132:Muscles / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D062559:NAV1.8 Voltage-Gated Sodium Channel; D015222:Sodium Channels / Q000235:genetics / Q000378:metabolism
D029721:Drosophila Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; D009124:Muscle Proteins; D062559:NAV1.8 Voltage-Gated Sodium Channel; D015222:Sodium Channels; C413082:kirre protein, Drosophila