title: Restoration of liver function and portosystemic pressure gradient after TIPSS and late TIPSS occlusion.
abstract: TIPSS (transjugular intrahepatic portosystemic shunt) may be indicated to control bleeding from esophageal and gastric varicose veins, to reduce ascites, and to treat patients with Budd-Chiari syndrome and veno-occlusive disease. Numerous measures to improve the safety and methodology of the procedure have helped to increase the technical and clinical success. Follow-up of TIPSS patients has revealed shunt stenosis to occur more often in patients with preserved liver function (Child A, Child B). In addition, the extent of liver cirrhosis is the main factor that determines prognosis in the long term. Little is known about the effects of TIPSS with respect to portosystemic hemodynamics. This report deals with a cirrhotic patient who stopped drinking 7 months prior to admission. He received TIPSS to control ascites and recurrent esophageal bleeding. Two years later remarkable hypertrophy of the left liver lobe and shunt occlusion was observed. The portosystemic pressure gradient dropped from 24 mmHg before TIPSS to 11 mmHg and remained stable after shunt occlusion. The Child's B cirrhosis prior to TIPSS turned into Child's A cirrhosis and remained stable during the follow-up period of 32 months. This indicates that liver function of TIPSS patients may recover due to hypertrophy of the remaining non-cirrhotic liver tissue. In addition the hepatic hemodynamics may return to normal. In conclusion, TIPSS cannot cure cirrhosis but its progress may be halted if the cause can be removed. This may result in a normal portosystemic gradient, leading consequently to shunt occlusion.
authors.affiliation: Department of Diagnostic Radiology, University of Heidelberg, Im Neuenheimer Feld 110, D-69120 Heidelberg, Germany. Ulrich_Maedler@yahoo.de
authors.forename: U
authors.initials: U
authors.lastname: Maedler
authors.forename: J
authors.initials: J
authors.lastname: Hansmann
authors.forename: M
authors.initials: M
authors.lastname: Duex
authors.forename: G
authors.initials: G
authors.lastname: Noeldge
authors.forename: P
authors.initials: P
authors.lastname: Sauer
authors.forename: G M
authors.initials: GM
authors.lastname: Richter
mesh_terms: D000328:Adult; D000792:Angiography; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D008102:Liver Circulation / Q000502:physiology; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000379:methods*; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016896:Treatment Outcome