Severe opiate withdrawal in a heroin user precipitated by a massive buprenorphine dose.
By diverting his dispensed medication, our patient collected 11 buprenorphine tablets (8 mg each), which he took in one day. The result was not respiratory depression, but instead severe opiate withdrawal lasting four days--this scenario has not previously been reported. This case highlights features of the unique pharmacology of buprenorphine and some key issues for its use in the management of heroin dependence.
Clark
Nicolas C
NC
Turning Point Alcohol & Drug Centre, Fitzroy, VIC. nicoc@turningpoint.org.au
Lintzeris
Nicholas
N
Muhleisen
Peter J
PJ
D000328:Adult; D002047:Buprenorphine / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D062787:Drug Overdose / Q000150:complications; D006556:Heroin Dependence / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D010349:Patient Compliance; D011957:Receptors, Opioid / Q000187:drug effects; D012651:Self Medication / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D002047:Buprenorphine