[Changes of SHBG concentrations in postmenopausal women].
Sex hormone-binding globulin (SHBG) is a serum (serous) glycoprotein binding estrogens and androgens with high affinity. Hepatic synthesis of SHBG and serous protein concentration are related to the following factors: age, sex steroids and thyroid hormones concentrations, obesity. Along with aging process, an increase of SHBG concentration is observed in both sexes. The following paper confirms a relation between age and SHBG concentration (positive correlation, p < 0.001) and a relation between body mass index (BMI) and SHBG. Concentration (r = -0.35, p < 0.039). In our studies it was found out that SHBG in postmenopausal women with recent hip fractures was significantly lower than in a group of women without fractures. The authors suggest that the determination of serum SHBG concentration might be assumed as a screening test for evaluation of the hip fracture risk in postmenopausal women.
Skałba
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Katedry i Kliniki Endokrynologii Ginekologicznej Slaskiej Akademii Medycznej w Katowicach.
Korfanty
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A
Mroczka
W
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Wójtowicz
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M
D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006620:Hip Fractures / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*; D017697:Premenopause / Q000097:blood; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D018709:Statistics, Nonparametric
D012738:Sex Hormone-Binding Globulin