title: Serum angiogenin concentrations in young patients with diabetes mellitus.
abstract: BACKGROUND
  Angiogenin serum levels were measured in a large group of type 1 diabetic young patients, looking at whether increased Angiogenin concentrations are associated with long-term glycemic control and microvascular complications.
  
  
  METHODS
  Four groups of patients were compared to 223 age- and sex- matched healthy controls: 196 type 1 diabetic patients (age range 3-24 years, onset of diabetes before the age of 12 years; duration of disease longer than 2 years), without microvascular complications were divided into three groups on the basis of age (group 1, n = 37, age < 6 years; group 2, n = 71, age 6-12 years; group 3, n = 88, age > 12 years); 53 adolescents and young adults (age 16.1-29.7 years) with diabetic microvascular complications (background, preproliferative or proliferative retinopathy, albumin excretion rate 20-200 microg min-1) (group 4).
  
  
  RESULTS
  Angiogenin serum levels were significantly increased in diabetic pre-school and pre-pubertal children, and particularly elevated in pubertal subjects compared with age- and sex-matched controls. Adolescents and young adults with microvascular complications had very high angiogenin concentrations. One-year mean HbA1c values were correlated with angiogenin levels (r = 0.389; p < 0.01). In poorly controlled diabetics (HbA1c > 10%), long-term (2 years) improvement of glycemic control determined a significant reduction of angiogenin concentrations in both pre-school and pre-pubertal children as well as in pubertal youngsters.
  
  
  CONCLUSIONS
  Angiogenin serum concentrations are increased in diabetic children even before puberty. Severity of microvascular complications is associated with markedly increased angiogenin serum levels. Long-term tight glycemic control determines a consistent reduction of angiogenin concentrations.
authors.affiliation: Department of Medicine, Division of Pediatrics, University of Chieti, Italy. chiarelli@unich.it
authors.forename: F
authors.initials: F
authors.lastname: Chiarelli
authors.forename: M
authors.initials: M
authors.lastname: Pomilio
authors.forename: A
authors.initials: A
authors.lastname: Mohn
authors.forename: S
authors.initials: S
authors.lastname: Tumini
authors.forename: A
authors.initials: A
authors.lastname: Verrotti
authors.forename: A
authors.initials: A
authors.lastname: Mezzetti
authors.forename: F
authors.initials: F
authors.lastname: Cipollone
authors.forename: M
authors.initials: M
authors.lastname: Wasniewska
authors.forename: G
authors.initials: G
authors.lastname: Morgese
authors.forename: A
authors.initials: A
authors.lastname: Spagnoli
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D012259:Ribonuclease, Pancreatic / Q000097:blood*
chemical_list: D006442:Glycated Hemoglobin; D012259:Ribonuclease, Pancreatic; C046366:angiogenin