title: Dose-dependent inhibition of the CYP2D6 catalyzed oxidation of sparteine by mepyramine in healthy volunteers.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey. skortunay@yahoo.com.tr
authors.forename: S
authors.initials: S
authors.lastname: Kortunay
authors.forename: A
authors.initials: A
authors.lastname: Bozkurt
authors.forename: N E
authors.initials: NE
authors.lastname: Basci
authors.forename: K
authors.initials: K
authors.lastname: Brøsen
authors.forename: S O
authors.initials: SO
authors.lastname: Kayaalp
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000378:metabolism*; D002384:Catalysis; D065690:Cytochrome P-450 CYP2D6 Inhibitors; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D010084:Oxidation-Reduction; D011738:Pyrilamine / Q000494:pharmacology*; D013034:Sparteine / Q000378:metabolism*
chemical_list: D000889:Anti-Arrhythmia Agents; D065690:Cytochrome P-450 CYP2D6 Inhibitors; D004791:Enzyme Inhibitors; D006634:Histamine H1 Antagonists; D013034:Sparteine; D011738:Pyrilamine