Plasminogen activator inhibitor 1: physiological and pathophysiological roles.
Plasminogen activator inhibitor 1 (PAI-1) inhibits plasminogen activators (u-PA and t-PA) by forming stable complexes endocytosed via a low-density lipoprotein receptor superfamily member-dependent mechanism. PAI-1 circulates actively in plasma and latently in platelets but is also secreted and deposited into the matrix by several cells, where it participates in tissue repair processes.
Binder
Bernd R
BR
Department of Vascular Biology and Thrombosis Research, University of Vienna, A-1090 Vienna, Austria. bernd.blinder@univie.ac.at
Christ
Günter
G
Gruber
Florian
F
Grubic
Nelly
N
Hufnagl
Peter
P
Krebs
Michael
M
Mihaly
Judit
J
Prager
Gerald W
GW
D020141:Hemostatic Disorders / Q000503:physiopathology*; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000737:chemistry / Q000502:physiology*; D014652:Vascular Diseases / Q000503:physiopathology*
D017395:Plasminogen Activator Inhibitor 1