Evaluation of immunoglobulin G and its subclasses in aplastic anemia.
We selected 31 patients with aplastic anemia to measure their total immunoglobulin (Ig) G and IgG subclasses and compared the results obtained with those obtained in the normal control group (n=461). Patients with aplastic anemia were classified into three subgroups according to severity: mild subgroup (n=14), moderate subgroup (n=12) and severe subgroup (n=5). The decrease in total IgG was recognized in all these three subgroups (p<0.001). Although IgG1 decreased in severe subgroup (p<0.01), it showed no significant difference in mild and moderate subgroups. The decrease in IgG2 and IgG3 was observed in all these three subgroups (p<0.001 and p<0.01, respectively). Although IgG4 decreased in mild subgroup (p<0.05), it showed no significant difference in moderate and severe subgroups. We speculated that the measurement of IgG subclasses was useful in understanding the pathophysiology of humoral immunity in aplastic anemia.
Yagi
T
T
Department of Laboratory Medicine, Osaka City General Hospital, Osaka, Japan.
Hasegawa
M
M
Kageyama
T
T
Teshima
H
H
Fujii
S
S
Tatsumi
N
N
D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000276:immunology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification*; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M