Benzoylphloroglucinol derivatives from Hypericum scabrum.
Nine new polyprenylated benzoylphloroglucinol derivatives, hyperibones A-I (1-9), were isolated from the aerial parts of the Uzbekistan medicinal plant Hypericum scabrum. Their structures were determined mainly on the basis of spectroscopic evidence (2D NMR and HRMS). Compounds 1, 2, and 4 showed mild in vitro antibacterial activity against methicillin-resistance Staphylococus aureus (MRSA) and methicillin-sensitive Staphylococus aureus (MSSA).
Matsuhisa
Michiko
M
Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, 770-8505, Japan.
Shikishima
Yasuhiro
Y
Takaishi
Yoshihisa
Y
Honda
Gisho
G
Ito
Michiho
M
Takeda
Yoshio
Y
Shibata
Hirohumi
H
Higuti
Tomihiko
T
Kodzhimatov
Olimjon K
OK
Ashurmetov
Ozodbek
O
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004352:Drug Resistance, Microbial; D020902:Hypericum / Q000737:chemistry*; D016106:Methicillin Resistance / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects*; D014610:Uzbekistan
D000900:Anti-Bacterial Agents; D010696:Phloroglucinol