Role of Neisseria meningitidis luxS in cell-to-cell signaling and bacteremic infection.
Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS deletion are defective for bacteremia, a prerequisite of meningococcal pathogenesis.
Winzer
Klaus
K
Institute of Infections and Immunity, Queen's Medical Centre, Nottingham NG9 2EX. United Kingdom.
Sun
Yao-hui
YH
Green
Andrew
A
Delory
Marie
M
Blackley
David
D
Hardie
Kim R
KR
Baldwin
Thomas J
TJ
Tang
Christoph M
CM
D000818:Animals; D016470:Bacteremia / Q000209:etiology*; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D013437:Carbon-Sulfur Lyases; D006714:Homoserine / Q000031:analogs & derivatives* / Q000032:analysis; D007783:Lactones / Q000032:analysis; D009345:Neisseria meningitidis / Q000235:genetics / Q000472:pathogenicity*; D051381:Rats; D017208:Rats, Wistar; D014774:Virulence
D001426:Bacterial Proteins; D007783:Lactones; C091088:N-octanoylhomoserine lactone; D006714:Homoserine; D013437:Carbon-Sulfur Lyases; C117753:LuxS protein, Bacteria