title: Halogenated metabolites from the new Okinawan red alga Laurencia yonaguniensis.
abstract: A novel brominated diterpene based on the rare neoirieane skeleton, named neoirietetraol (1), has been isolated along with a halogenated C15 acetogenin, (3Z)-laurenyne (2), from a new Laurencia species, L.yonaguniensis Masuda et Abe, species inedita, collected at Yonaguni Island, Okinawa Prefecture, Japan. The structures of these metabolites were elucidated by spectroscopic data (IR, 1H NMR, 13C NMR, 2D NMR, and MS). Neoirietetraol (1) was toxic to the brine shrimp (Altemia salina; LC50, 40.1 microM) and also showed weak antibacterial activities against two marine bacteria, Alcaligenes aquamarinus and Escherichia coli.
authors.affiliation: Division of Material Science, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Motonari
authors.initials: M
authors.lastname: Daitoh
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Abe
authors.forename: Michio
authors.initials: M
authors.lastname: Masuda
mesh_terms: D000421:Alcaligenes / Q000187:drug effects; D020591:Alteromonas / Q000187:drug effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004885:Erwinia / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D019625:Halococcus / Q000187:drug effects; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007564:Japan; D013058:Mass Spectrometry; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011548:Pseudomonadaceae / Q000187:drug effects; D000461:Rhodophyta / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D006573:Heterocyclic Compounds, 1-Ring; D006843:Hydrocarbons, Chlorinated; C455739:laurenyne; C455740:neoirietetraol