Sensitivity to glutamate neurotoxicity in different developmental periods of the rat cochlea.
Cochlear neurotoxicity induced by the intraperitoneal administration of monosodium glutamate (MSG) has been analyzed during the postnatal development of the auditory receptor of the rat. The animals were treated with MSG during two postnatal periods. The electrophysiological recordings showed that MSG treatment produced a decrease in the 8th nerve compound action potential. The effect was more marked in the animals treated between the 9th and 12th postnatal day than in the others, with a qualitative decrease in neuronal density in the spiral ganglion. These results suggest that there is a period of maximum sensitivity to the cochlear neurotoxicity induced by MSG in the postnatal development of the rat.
Carricondo
F
F
Agustín Bullón Cell Culture Center and Department of Surgery II (ORL), Faculty of Medicine, University Complutense, Madrid, Spain.
Bartolomé
M V
MV
Vicente-Torres
M A
MA
Fernández-Pacheco
P
P
Rodríguez
T
T
Gil-Loyzaga
P
P
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D001306:Auditory Pathways / Q000187:drug effects / Q000254:growth & development; D003051:Cochlea / Q000187:drug effects* / Q000254:growth & development / Q000473:pathology; D003056:Cochlear Nerve / Q000187:drug effects / Q000503:physiopathology; D004342:Drug Hypersensitivity / Q000209:etiology*; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D012970:Sodium Glutamate / Q000009:adverse effects*; D013136:Spiral Ganglion / Q000187:drug effects / Q000473:pathology
D012970:Sodium Glutamate