title: Near-total laryngectomy in advanced laryngeal and pyriform cancers.
abstract: OBJECTIVE
  To demonstrate the oncologic and physiological safety of near-total laryngectomy (NTL), its success in voice conservation, and its versatility for use in extensive resections that necessitate pharyngoplasty, and even in post-radiation recurrences.
  
  
  METHODS
  In this study of 137 cases of NTL for cancer of the larynx (45 cases) and pyriform (92 cases), 86.9% were stage T3/T4 and 60.6% were N+. A total of 8.8% had extended pharyngeal resections necessitating patch pharyngoplasty (ENTLP). In 10.9% cases, NTL was used as salvage of post-radiation failures. Concurrent neck dissection was performed in 99 cases.
  
  
  RESULTS
  A total of 70.1% was alive and disease-free at the last follow-up ranging from 12 months to 104 months (median, 35 mo). A total of 7.3% had local/locoregional recurrences and 11.7% had purely regional recurrences. The local control rate for post-radiation salvage with NTL was 93.3%. A total of 88.6% developed communicable speech, and the speech success rate was 100% in 12 cases of ENTLP. Complications included major wound dehiscence with total shunt breakdown in 2 cases (1.5%), pharyngeal leak requiring surgical intervention in 7 cases (3.6%), significant aspiration through the shunt necessitating completion laryngectomy in 1 case (0.7%), and complete shunt stenosis in 9 cases (6.6%).
  
  
  CONCLUSIONS
  The study shows that NTL is an oncologically safe voice conservation procedure in advanced, lateralized laryngeal and pyriform cancers treated not only per primum, but also in carefully selected post-radiation failures. It has a high success rate of speech development even in those cases requiring extensive pharyngeal resections. Major complications were acceptably low.
authors.affiliation: Head and Neck Services, Tata Memorial Hospital, Parel, Mumbai, India. pradhansultan@hotmail.com
authors.forename: Sultan A
authors.initials: SA
authors.lastname: Pradhan
authors.forename: Anil K
authors.initials: AK
authors.lastname: D'Cruz
authors.forename: Prathamesh S
authors.initials: PS
authors.lastname: Pai
authors.forename: Azeem
authors.initials: A
authors.lastname: Mohiyuddin
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D007825:Laryngectomy / Q000009:adverse effects / Q000379:methods* / Q000534:rehabilitation; D007828:Laryngoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017678:Sex Distribution; D015996:Survival Rate; D016896:Treatment Outcome