Antibodies against gangliosides: a link between preceding infection and immunopathogenesis of Guillain-Barré syndrome.
Autoantibodies against gangliosides GM1 and GQ1b, characteristic cell surface glycolipids of the nervous system, are present in specific clinical types of GuillainBarré syndrome (GBS). Close associations of anti-GM1 with acute motor axonal neuropathy, and of anti-GQ1b with Miller Fisher syndrome, strongly suggest that these antibodies contribute to neuropathy pathogenesis. Immune responses against gangliosides are suspected to originate as a result of molecular mimicry between gangliosides and lipopolysaccharides of Campylobacter jejuni, the most frequent infectious trigger of GBS. Thus, antibodies against gangliosides may link C. jejuni infection with the precipitation of neurological disease.
Schwerer
Beatrix
B
Department of Neuroimmunology, Brain Research Institute, University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria. beatrix.schwerer@univie.ac.at
D001323:Autoantibodies / Q000276:immunology*; D002240:Carbohydrate Sequence; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007239:Infections / Q000150:complications*; D018448:Models, Immunological; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry / Q000276:immunology
D001323:Autoantibodies; D005732:Gangliosides; D009844:Oligosaccharides