title: Effects of aging on C57BL/6J mice: an electrophysiological and morphological study.
abstract: Presbycusis is a progressive hearing loss associated with aging that manifests as deafness linked to cochlear morphological degeneration. The effects of aging on the auditory system were studied in C57BL/6J mice using electrophysiological (brainstem auditory evoked potentials; BAEP) and morphological techniques. Cochleae of animals aged 1, 6, 9, 12, 15, 18, 21, or 24 months old were used for that purpose. The BAEP showed a progressive increase in latency and a reduction in amplitude. Morphological studies demonstrated total degeneration of the organ of Corti, which was replaced by a single epithelial layer. An affinity histochemistry study demonstrated minor modifications of glycoconjugates in the organ of Corti during the aging process.
authors.affiliation: Center of Cell Culture (CAI-UCM) and Department of Surgery II (ORL), Faculty of Medicine, University Complutense, Madrid, Spain.
authors.forename: Maria Visitación
authors.initials: MV
authors.lastname: Bartolomé
authors.forename: Castillo Eduardo
authors.initials: CE
authors.lastname: del
authors.forename: Lorena Maestre
authors.initials: LM
authors.lastname: López
authors.forename: Francisco
authors.initials: F
authors.lastname: Carricondo
authors.forename: Joaquin
authors.initials: J
authors.lastname: Poch-Broto
authors.forename: Pablo
authors.initials: P
authors.lastname: Gil-Loyzaga
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D003051:Cochlea / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D006001:Glycoconjugates / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009925:Organ of Corti / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D011304:Presbycusis / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D006001:Glycoconjugates