title: Peritoneal fluid and solute transport: influence of treatment time, peritoneal dialysis modality, and peritonitis incidence.
abstract: The integrity of the peritoneal membrane in peritoneal dialysis (PD) is of major importance for adequate dialysis and fluid balance. However, alterations in peritoneal fluid transport, such as ultrafiltration failure, often develop during long-term PD. To investigate peritoneal solute and fluid transport and to analyze the influence of treatment time, peritonitis incidence, and PD modality (continuous ambulatory PD [CAPD] or automated PD [APD]), a cross-sectional study with an extended peritoneal transport test that used dextran 70 in 2 L of glucose was performed in 23 nonselected chronic PD patients. Compared were long-term (>40 mo) with short-term PD patients (<40 mo), CAPD with APD patients, and those with a peritonitis incidence of >0.25/yr to those with an incidence of <0.25/yr. Dialysate/plasma (D/P) ratio and mass transfer area coefficient of creatinine, lymphatic absorption rate (LAR), transcapillary ultrafiltration, and effective ultrafiltration were measured. Long-term PD patients had higher D/P ratio of creatinine (73.5 +/- 2.3% versus 65.9 +/- 2.2%; P < 0.01) and higher LAR (243 +/- 69 ml/4 h versus 96 +/- 31 ml/4 h; P < 0.03), both resulting in lower effective ultrafiltration (242 +/- 35 ml/4 h versus 324 +/- 30 ml/4 h; P < 0.05). D/P ratio (r = 0.66) and LAR (r = 0.67) were positively correlated to PD duration. Patients on APD compared with those on CAPD and patients with a history of peritonitis compared with those without did not differ in terms of D/P ratio, mass transfer area coefficient, LAR, transcapillary ultrafiltration, and effective ultrafiltration. Lower ultrafiltration after long-term PD is both the result of increased small solute transport and increased lymphatic absorption. APD or CAPD modality and peritonitis incidence do not have a significant influence on small solute transport or fluid kinetics.
authors.affiliation: Department of Nephrology and Rheumatology, Heinrich Heine-University, Düsseldorf, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Fußhöller
authors.affiliation: Department of Nephrology and Rheumatology, Heinrich Heine-University, Düsseldorf, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Zur Nieden
authors.affiliation: Department of Nephrology and Rheumatology, Heinrich Heine-University, Düsseldorf, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Grabensee
authors.affiliation: Department of Nephrology and Rheumatology, Heinrich Heine-University, Düsseldorf, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Plum
mesh_terms: D001202:Ascitic Fluid / Q000378:metabolism*; D001331:Automation; D001692:Biological Transport; D003430:Cross-Sectional Studies; D003911:Dextrans / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects* / Q000379:methods*; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D010538:Peritonitis / Q000453:epidemiology / Q000209:etiology*; D013997:Time Factors
chemical_list: D003911:Dextrans