Neurotoxicologic sequelae of tributyltin intoxication in rats.
Tributyltin oxide (TBTO) is a commonly used biocide. The purpose of this study is to correlate the toxicity of TBTO with the alterations of brain neurotransmitters and ATPases. TBTO was given by stomach tube to rats at either 37.5 or 75 mg x kg (-1)for 3 consecutive days. Nervous signs appeared in treated animals and the mortality reached 12 and 30%, respectively. The levels of brain dopamine, norepinephrine and serotonin decreased in a dose-dependent manner. The activities of brain total ATPase, Mg (2+)-ATPase and Na (+)/K (+)- ATPase were suppressed. The activity of Na (+)/K (+)- ATPase was more severely affected than that of Mg (2+)-ATPase. Histopathological changes in brain included hyperaemia, focal haemorrhages in vacuolated myelinated fibres, chromatolysis, or complete necrosis of neurons, degenerative changes, or complete absence of purkinje cells in the cerebellum.
Elsabbagh
Hesham S
HS
Departments of Toxicology and Forensic Medicine and Biochemistry, Faculty of Veterinary Medicine, Cairo University, Egypt.
Moussa
Said Z
SZ
El-tawil
Osama S
OS
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors; D002543:Cerebral Hemorrhage / Q000139:chemically induced; D004202:Disinfectants / Q000633:toxicity*; D004298:Dopamine / Q000378:metabolism; D006940:Hyperemia / Q000139:chemically induced; D008297:Male; D009410:Nerve Degeneration / Q000139:chemically induced; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D014220:Trialkyltin Compounds / Q000633:toxicity*
D004202:Disinfectants; D014220:Trialkyltin Compounds; D012701:Serotonin; C005961:bis(tri-n-butyltin)oxide; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D004298:Dopamine; D009638:Norepinephrine