Transgenic analysis of thymocyte signal transduction.
This review examines the value of transgenic studies in mice for the genetic dissection of signal-transduction pathways relevant to thymus development. T-cell development in the thymus is controlled by an ordered sequence of differentiation and proliferation checkpoints that culminate in the production of correctly selected, non-autoreactive, peripheral T lymphocytes. Work in transgenic mice has been fundamental for the preparation of genetic maps of signal-transduction pathways that control T-cell development. This review discusses how tyrosine kinases, guanine-nucleotide-binding proteins and transcription factors converge to control T-cell differentiation and proliferation in the immune system.
Cantrell
Doreen A
DA
Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. d.cantrell@icrf.icnet.uk
D000818:Animals; D001427:Bacterial Toxins / Q000235:genetics / Q000276:immunology; D002454:Cell Differentiation; D002455:Cell Division; D019204:GTP-Binding Proteins / Q000235:genetics / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D018448:Models, Immunological; D009154:Mutation; D011401:Promoter Regions, Genetic; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics* / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology; D018631:ras Proteins / Q000235:genetics / Q000276:immunology
D001427:Bacterial Toxins; D014157:Transcription Factors; D011505:Protein-Tyrosine Kinases; D019204:GTP-Binding Proteins; D018631:ras Proteins