title: Antiproliferative action of vitamin D.
abstract: During the past few years, it has become apparent that vitamin D may play an important role in malignant transformation. Epidemiological studies suggest that low vitamin D serum concentration increases especially the risk of hormone-related cancers. Experimentally, vitamin D suppresses the proliferation of normal and malignant cells and induces differentiation and apoptosis. In the present review we discuss the mechanisms whereby vitamin D regulates cell proliferation and whether it could be used in prevention and treatment of hyperproliferative disorders like cancers.
authors.affiliation: Graduate School of Biomedicine, Department of Cell Biology, 33014 University of Tampere, Finland.
authors.forename: Timo
authors.initials: T
authors.lastname: Ylikomi
authors.forename: Ilkka
authors.initials: I
authors.lastname: Laaksi
authors.forename: Yan-Ru
authors.initials: YR
authors.lastname: Lou
authors.forename: Paula
authors.initials: P
authors.lastname: Martikainen
authors.forename: Susanna
authors.initials: S
authors.lastname: Miettinen
authors.forename: Pasi
authors.initials: P
authors.lastname: Pennanen
authors.forename: Sami
authors.initials: S
authors.lastname: Purmonen
authors.forename: Heimo
authors.initials: H
authors.lastname: Syvälä
authors.forename: Annika
authors.initials: A
authors.lastname: Vienonen
authors.forename: Pentti
authors.initials: P
authors.lastname: Tuohimaa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006131:Growth Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D014807:Vitamin D / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D014807:Vitamin D