[Diagnosis of holoprosencephalia. Report of 17 cases].
OBJECTIVE
To establish the epidemiologic profile of holoprosencephalia and determine benefits of ultrasound and foetopathologic examination to the diagnostic. METHODS AN MATERIAL: [corrected] Retrospective study about 17 cases of holoprosencephalia observed in CMNT between Janaury 1992 and September 2000.


RESULTS
Ultrasound diagnosis was made in 13 cases (75%). Ultrasound criteria were; absence of median structure of the brain and unique ventricule. The prognosis was always bad. Foetopathologic examination revealed 7 cases of lobar holoproencephalia and 10 of semi lobar. Fascial dysmorphia were noted in 82% of cases.


CONCLUSIONS
The foetopathology and genetic counselling looking for fascial, dysmorphia in family's members gives a good evaluation of recurrences.
Siala Gaigi
S
S
Centre de Maternité et de Néonatologie de Tunis.
Masmoudi
A
A
Chennoufi
M B
MB
Jabnoun
S
S
Ben Romdhane
B
B
Chaabouni
M
M
Mabrouk
A
A
Neji
K
K
Chabchoub
A
A
Sfar
E
E
Lebbi
I
I
Zouari
F
F
Chelli
H
H
Rezigua
H
H
Chaabouni
H
H
Khrouf
N
N
D000328:Adult; D002869:Chromosome Aberrations; D005145:Face / Q000002:abnormalities; D005260:Female; D016142:Holoprosencephaly / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal