title: 1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy.
abstract: 1H MRS imaging (MRSI) was performed on 15 patients with MRI-negative temporal lobe epilepsy (TLE) who underwent seizure surgery. The non-seizure-free patients (NSF) ipsilateral hippocampal N-acetylaspartate (NAA)/(Cr+Cho) z scores were lower than the contralateral scores (p = 0.04), and the NSF ipsilateral z scores were lower than the seizure-free patients' (SF) ipsilateral z scores (p = 0.0049). Similarly, NSF contralateral scores were lower than contralateral SF (p = 0.02). These findings suggest NAA predicts the surgical outcome in patients with TLE without evidence of mesial temporal sclerosis on MRI.
authors.affiliation: Department of Radiology, University of California, San Francisco 94143-0138, USA.
authors.forename: J
authors.initials: J
authors.lastname: Suhy
authors.forename: K D
authors.initials: KD
authors.lastname: Laxer
authors.forename: A A
authors.initials: AA
authors.lastname: Capizzano
authors.forename: P
authors.initials: P
authors.lastname: Vermathen
authors.forename: G B
authors.initials: GB
authors.lastname: Matson
authors.forename: N M
authors.initials: NM
authors.lastname: Barbaro
authors.forename: M W
authors.initials: MW
authors.lastname: Weiner
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism*; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011237:Predictive Value of Tests; D013223:Statistics as Topic; D013702:Temporal Lobe / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D001224:Aspartic Acid; C000179:N-acetylaspartate