Novel approaches to tackling malarial drug resistance using yeast.
Yeasts have a justified reputation as one of the world's most versatile organisms. Baker's yeast continues to live up to this recognition by joining the war against malaria. Yeast can now be used to study antifolate drug resistance patterns that depend on the dihydrofolate reductase enzyme (DHFR) from the malaria parasite.
Sibley
C H
CH
Department of Genetics, University of Washington, Seattle, USA.
Macreadie
I
I
D000962:Antimalarials / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008954:Models, Biological; D020411:Oligonucleotide Array Sequence Analysis; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*
D000962:Antimalarials; D013762:Tetrahydrofolate Dehydrogenase