title: Treatment paradigms in heart failure.
abstract: Heart failure patients suffer very severe morbidity, high mortality and are common in medical practice. Their need for effective treatments is only partially answered by current options. Effective treatments often address cellular and pathophysiological mechanisms which are involved in the progression of heart failure. This article reviews those mechanisms and treatments.
authors.affiliation: Heart Hospital, UCLH/Middlesex Hospitals, London W1N 8AA.
authors.forename: Andrew R W
authors.initials: AR
authors.lastname: Money-Kyrle
authors.forename: Adam D
authors.initials: AD
authors.lastname: Timmis
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000638:Amiodarone / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002303:Cardiac Output, Low / Q000628:therapy*; D003971:Diastole; D004594:Electrophysiology; D005080:Exercise Test; D016027:Heart Transplantation; D006801:Humans; D017466:Receptors, Endothelin / Q000627:therapeutic use; D019616:Thoracic Surgical Procedures
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D017466:Receptors, Endothelin; D000638:Amiodarone