Eradication of initial Pseudomonas aeruginosa colonization in patients with cystic fibrosis.
The optimal treatment for the eradication of initial P. aeruginosa infection in CF is still unclear. Recently long-term inhaled tobramycin has been proposed. Here we report the results with brief inhaled and/or systemic anti-pseudomonal treatments. Initial P. aeruginosa colonization was successfully eradicated as demonstrated by negative repetitive throat cultures or sputa and serum antipseudomonal antibodies in 15 of 17 patients for at least two years. Randomized, controlled trials are urgently needed to define the optimal protocol for the eradication of P. aeruginosa. Pseudomonas aeruginosa, infection, treatment, antibodies; inhaled tobramycin
Griese
Matthias
M
Kinderpoliklinik, Childrens' Hospital, University of Munich, Munich, Germany. griese@pk-i.med.uni-muenchen.de
Müller
I
I
Reinhardt
D
D
D000280:Administration, Inhalation; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002442:Ceftazidime / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D002939:Ciprofloxacin / Q000008:administration & dosage; D003091:Colistin / Q000008:administration & dosage; D003550:Cystic Fibrosis / Q000150:complications*; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D011552:Pseudomonas Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D014031:Tobramycin / Q000008:administration & dosage; D016896:Treatment Outcome
D002939:Ciprofloxacin; D002442:Ceftazidime; D014031:Tobramycin; D003091:Colistin