Reversal of pulmonary hypertension associated with plexiform lesions in congenital heart disease: a case report.
We describe a 2-year-old child with severe pulmonary hypertension due to a patent ductus arteriosus (PDA) with plexiform lesions on lung biopsy. Despite high basal pulmonary vascular resistance with minimal responsiveness to inhaled nitric oxide and other vasodilators, and advanced plexogenic arteriopathy on lung biopsy, her pulmonary hypertension completely resolved after PDA ligation and during 8 years of follow-up.
Epting
C L
CL
Section of Pediatric Cardiology, The Pediatric Heart Lung Center, B100 The Children's Hospital, 1056 E, 19th Avenue, Denver, CO 80218, USA.
Wolfe
R R
RR
Abman
S H
SH
Deutsch
G H
GH
Ivy
D
D
D002675:Child, Preschool; D004374:Ductus Arteriosus, Patent / Q000150:complications* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008168:Lung / Q000473:pathology; D016896:Treatment Outcome; D014655:Vascular Resistance