title: Maternal benefit of corticosteroid therapy in patients with HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome: impact on the rate of regional anesthesia.
abstract: OBJECTIVE
  Our purpose was to assess the impact of glucocorticoid administration on the rate of regional anesthesia in women with hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome.
  
  
  METHODS
  Maternal records of pregnancies with HELLP syndrome managed between April 1994 and December 1999 were analyzed retrospectively.
  
  
  RESULTS
  Sixty-nine patients were identified with antepartum HELLP syndrome and 46 (66%) received glucocorticoids. The presence of thrombocytopenia at admission and the interval from presentation to delivery was evaluated to assess the impact of glucocorticoid use. In the 37 women who had platelet counts of <90,000/mm3, 0 in the untreated group (0 of 11) versus 42% in the steroid group (11 of 26) received regional anesthetic, P =.015. Furthermore, the rate of regional anesthesia increased from 0 in the untreated group delivered within 24 hours (n = 10) to 57% (8 of 14) in the glucocorticoid group, in which women attained a 24-hour latency from presentation to delivery, P =.006. The need for general anesthesia also decreased significantly in treated women who attained a 24-hour latency compared to untreated women who did not, 100% (n = 7) versus 22% (n = 9), P =.003.
  
  
  CONCLUSIONS
  Administration of glucocorticoids increases the use of regional anesthesia in women with antepartum HELLP syndrome who have thrombocytopenia, particularly in those who achieve a latency of 24 hours before delivery.
authors.affiliation: Department of Maternal-Fetal Medicine, Central Baptist Hospital Lexington, Ky 40503, USA. jobrien@bhsi.com
authors.forename: J M
authors.initials: JM
authors.lastname: O'Brien
authors.forename: S A
authors.initials: SA
authors.lastname: Shumate
authors.forename: S L
authors.initials: SL
authors.lastname: Satchwell
authors.forename: D A
authors.initials: DA
authors.lastname: Milligan
authors.forename: J R
authors.initials: JR
authors.lastname: Barton
mesh_terms: D000328:Adult; D000765:Anesthesia, Conduction; D000768:Anesthesia, General; D036861:Delivery, Obstetric; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D017359:HELLP Syndrome / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D010976:Platelet Count; D011247:Pregnancy; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications; D013997:Time Factors
chemical_list: D005938:Glucocorticoids