AMOP, a protein module alternatively spliced in cancer cells.
This article describes a new extracellular domain--AMOP, for adhesion-associated domain in MUC4 and other proteins. This domain occurs in putative cell adhesion molecules and in some splice variants of MUC4. MUC4 splice variants are overexpressed in several tumours; in particular, they are highly expressed in pancreatic carcinomas but not in normal pancreas. The presence of AMOP in cell adhesion molecules could be indicative of a role for this domain in adhesion.
Ciccarelli
Francesca D
FD
Doerks
Tobias
T
Bork
Peer
P
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D014408:Biomarkers, Tumor / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D055264:Mucin-4; D009077:Mucins / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000235:genetics*; D011379:Prognosis; D017386:Sequence Homology, Amino Acid
D014408:Biomarkers, Tumor; C524658:MUC4 protein, human; D055264:Mucin-4; D009077:Mucins