title: [Early-onset generalized polyarthritis (Stickler syndrome)].
abstract: A 25-years old woman complained of pain especially in the knees and hips since she was 11 years old. Her pain worsened with weight bearing and activity. Aged 16 she underwent a transposition osteotomy of the right femoral neck. Clinical and radiographic examination demonstrated an early-onset polytopic osteoarthritis. The molecular DNA analysis confirmed the diagnosis of Stickler syndrome. The present case report demonstrates the importance of early recognition of the diagnosis and the management of osteoarthritis.
authors.affiliation: Abteilung für Stoffwechselund Molekularerkrankungen, Kinderspital, Universität Zürich. jiri.mach@ruz.usz.ch
authors.forename: J
authors.initials: J
authors.lastname: Mach
authors.forename: D
authors.initials: D
authors.lastname: Sobetzko
authors.forename: A
authors.initials: A
authors.lastname: Superti-Furga
authors.forename: Th
authors.initials: T
authors.lastname: Stoll
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D005260:Female; D005272:Femur Neck / Q000601:surgery; D006801:Humans; D010003:Osteoarthritis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery; D010027:Osteotomy; D011859:Radiography; D013577:Syndrome; D013997:Time Factors