title: Effects of mutations at the stambh A locus of Drosophila melanogaster.
abstract: We report novel findings on the cytogenetic location, functional complexity and maternal and germline roles of the stambh A locus of Drosophila melanogaster. stmA is localized to polytene bands 44D1.2 on 2R. stmA mutations are of two types: temperature-sensitive (ts) adult and larval paralytic or unconditional embryonic or larval lethal. Twelve alleles reported in this study fall into two intragenic complementing groups suggesting that stmA is a complex locus with more than one functional domain. Some unconditional embryonic lethal alleles show a 'neurogenic' phenotype of cuticle loss accompanied by neural hypertrophy. It is shown that embryos of ts paralytic alleles also show mild neural hypertrophy at permissive temperatures while short exposure to heat induces severe cuticle loss in these embryos. stmA exerts a maternal influence over heat-induced cuticle loss. Unconditional embryonic lethal alleles of stmA are also germline lethal.
authors.affiliation: Division of Genetics, Indian Agricultural Research Institute, New Delhi 110 012, India.
authors.forename: M
authors.initials: M
authors.lastname: Kumar
authors.forename: M
authors.initials: M
authors.lastname: Joseph
authors.forename: S
authors.initials: S
authors.lastname: Chandrashekaran
mesh_terms: D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D004475:Ectoderm / Q000502:physiology; D005260:Female; D017344:Genes, Insect; D005816:Genetic Complementation Test; D006358:Hot Temperature; D008297:Male; D009154:Mutation; D009420:Nervous System / Q000196:embryology; D017422:Sequence Analysis, DNA