The Mouse Tumor Biology Database: a public resource for cancer genetics and pathology of the mouse.
Developing genetic mouse models for cancer research has been recognized as an "exceptional opportunity" by the National Cancer Institute. The establishment of bioinformatics resources to facilitate access to published and unpublished data on the genetics and pathology of cancer in different strains of the laboratory mouse is critical to developing and using mouse models of human disease. In this article, we review the Mouse Tumor Biology Database (MTB), a public resource for information on cancer genetics, epidemiology, and pathology in genetically defined mice. We outline current content, data acquisition strategies, and query mechanisms for MTB. MTB is accessible on-line at http://tumor.informatics.jax.org.
Näf
Dieter
D
Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, Maine 04609, USA. dnaf@informatics.jax.org
Krupke
Debra M
DM
Sundberg
John P
JP
Eppig
Janan T
JT
Bult
Carol J
CJ
D000818:Animals; D019295:Computational Biology; D019992:Databases as Topic; D051379:Mice / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D012376:Rodent Diseases / Q000235:genetics* / Q000473:pathology