Transcriptional mechanisms regulating myeloid-specific genes.
Myeloid blood cells comprise an important component of the immune system. Proper control of both lineage- and stage-specific gene expression is required for normal myeloid cell development and function. In recent years, a relatively small number of critical transcriptional regulators have been identified that serve important roles both in myeloid cell development and regulation of lineage-restricted gene expression in mature myeloid cells. This review summarizes our current understanding of the regulation of lineage- and stage-restricted transcription during myeloid cell differentiation, how critical transcriptional regulators control myeloid cell development, and how perturbations in transcription factor function results in the development of leukemia.
Skalnik
David G
DG
Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA. dskalnik@iupui.edu
D000818:Animals; D019070:Cell Lineage / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D022423:Myeloid Cells / Q000166:cytology / Q000378:metabolism*; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics*
D014157:Transcription Factors