Pyrano-isoflavones with erectile-dysfunction activity from Eriosema kraussianum.
Five pyrano-isoflavones have been isolated from the rootstock of Eriosema kraussianum N. E. Br (Papilionaceae). Spectral data and single crystal X-ray analyses were used for structural elucidation. The most active of the compounds had an activity of 75% of that found in Viagra in the erectile dysfunction test on rabbit penile smooth muscle.
Drewes
Siegfried E
SE
School of Chemical and Physical Sciences, University of Natal, P. Bag X01, Scottsville, 3209, Pietermaritzburg, South Africa. drewes@nu.ac.za
Horn
Marion M
MM
Munro
Orde Q
OQ
Dhlamini
Jabu T B
JT
Meyer
J J Marion
JJ
Rakuambo
N Christopher
NC
D000818:Animals; D001681:Biological Assay; D018360:Crystallography, X-Ray; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D023421:Models, Animal; D010410:Penile Erection / Q000187:drug effects*; D027805:Phaseolus / Q000737:chemistry*; D011817:Rabbits
D007529:Isoflavones; C465002:kraussianone 1