Paracrine dialogue in implantation.
We know that the implantation process requires a functionally normal embryo at the blastocyst stage and a receptive endometrium, but also a communication link between them is needed. This paracrine dialogue between the embryo, endometrium and the corpus luteum are known to occur in ruminants and primates, more specifically endometrial-embryonic interactions have been reported in rodents and primates but not in humans. This process is a highly regulated mechanism and many molecules take part in this cross-talk. Here, we present updated information in humans on the embryonic regulation of endometrial epithelial molecules such as chemokines, adhesion and anti-adhesion molecules, and leptin during the apposition and adhesion phases of human implantation.
Dominguez
F
F
Fundación Instituto Valenciano de Infertilidad para el Estudio de la Reproducción Humana, Guardia Civil 23, 46020 Valencia, Spain.
Pellicer
A
A
Simón
C
C
D001755:Blastocyst / Q000166:cytology / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D002448:Cell Adhesion; D018925:Chemokines / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D010064:Embryo Implantation / Q000502:physiology*; D004624:Embryo Transfer; D004717:Endometrium / Q000378:metabolism; D004727:Endothelium / Q000166:cytology / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D020738:Leptin / Q000502:physiology; D018396:Mucin-1 / Q000502:physiology; D019899:Paracrine Communication; D011247:Pregnancy; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin
D002352:Carrier Proteins; D018925:Chemokines; D016207:Cytokines; D012739:Gonadal Steroid Hormones; D020738:Leptin; D018396:Mucin-1; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin