title: The aversive properties of acute morphine dependence persist 48 h after a single exposure to morphine: evaluation by taste and place conditioning.
abstract: The aversive properties of naloxone-precipitated morphine withdrawal from acutely administered morphine were assessed following a single conditioning trial using both the place conditioning and the taste conditioning paradigm. In both paradigms, the aversive properties of naloxone-precipitated morphine withdrawal were evident up to 48 h after a single injection of morphine. In neither paradigm did naloxone treatment alone produce an aversion after a single conditioning trial. These results suggest that a single morphine exposure produces long-lasting effects that persist at least 48 h beyond the agonist effects of the opiate.
authors.affiliation: Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5. lparker@wlu.ca
authors.forename: Linda A
authors.initials: LA
authors.lastname: Parker
authors.forename: Joan A
authors.initials: JA
authors.lastname: Cyr
authors.forename: Andrea N
authors.initials: AN
authors.lastname: Santi
authors.forename: Page D
authors.initials: PD
authors.lastname: Burton
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D009021:Morphine Dependence; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013649:Taste / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
chemical_list: D009270:Naloxone; D009020:Morphine