Prediction of gene function in methylthioadenosine recycling from regulatory signals.
The S-box transcription termination control system, first identified in Bacillus subtilis, is used for regulation of gene expression in response to methionine availability. The presence of the S-box motif provided the first indication that the ykrTS and ykrWXYZ genes could play a role in recycling of 5'-methylthioadenosine, a by-product of polyamine biosynthesis that can be converted to methionine. In this study we demonstrate a role for the ykrTS and ykrWXYZ gene products in this pathway.
Murphy
Brooke A
BA
Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA.
Grundy
Frank J
FJ
Henkin
Tina M
TM
D001412:Bacillus subtilis / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D003839:Deoxyadenosines / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial / Q000502:physiology*; D008715:Methionine / Q000096:biosynthesis*; D008969:Molecular Sequence Data; D013872:Thionucleosides / Q000378:metabolism*
D003839:Deoxyadenosines; D013872:Thionucleosides; C008500:5'-methylthioadenosine; D008715:Methionine