Possible involvement of a muscarinic receptor in the anti-allodynic action of a 5-HT2 receptor agonist in rats with nerve ligation injury.
Intrathecal administration of 5-HT(2) receptor agonists produces an anti-allodynic effect in a rat model of neuropathic pain. Several non-serotonergic neurotransmitters have been implicated these anti-nociceptive effects. In the present study, intrathecal pre-treatment with the muscarinic receptor antagonist atropine (10 and 30 microg) and pirenzepine (10 microg) reversed the anti-allodynic effect of the 5-HT(2) receptor agonist alpha-methyl-5-hydroxytryptamine, unlike various other antagonists. Thus, muscarinic receptors may be involved in the anti-allodynic action of intrathecally injected 5-HT(2) receptor agonist.
Obata
Hideaki
H
Department of Anesthesiology and Reanimatology, Gunma University, School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan. hobata@showa.gunma-u.ac.jp
Saito
Shigeru
S
Sasaki
Masayuki
M
Goto
Fumio
F
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D007278:Injections, Spinal; D008026:Ligation; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D011976:Receptors, Muscarinic / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000031:analogs & derivatives* / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013127:Spinal Nerves / Q000187:drug effects / Q000293:injuries / Q000502:physiology*
D000700:Analgesics; D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; C042390:alpha-methylserotonin; D012701:Serotonin