title: Purification and characterization of the aetiological agent of hydropericardium hepatitis syndrome from infected liver tissues of broiler chickens.
abstract: Hydropericardium hepatitis syndrome in broiler chickens is an acute, infectious disease characterized by high mortality, excess pericardial fluid and multifocal hepatic necrosis. The aetiological agent was purified to homogeneity from infected liver tissues from field outbreaks. Electron-microscopic and serological confirmation of the virus were undertaken and the disease was reproduced experimentally in broiler chicks. The results indicated that an adenovirus, fowl adenovirus serotype 4, was alone responsible for the disease in the materials studied.
authors.affiliation: Indian Veterinary Research Institute, Bangalore 560024, India.
authors.forename: K
authors.initials: K
authors.lastname: Ganesh
authors.forename: R
authors.initials: R
authors.lastname: Raghavan
authors.forename: R N S
authors.initials: RN
authors.lastname: Gowda
authors.forename: M L
authors.initials: ML
authors.lastname: Satyanarayana
authors.forename: V V S
authors.initials: VV
authors.lastname: Suryanarayana
mesh_terms: D000257:Adenoviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D000818:Animals; D000259:Aviadenovirus / Q000302:isolation & purification* / Q000648:ultrastructure; D002645:Chickens; D004196:Disease Outbreaks / Q000662:veterinary; D006524:Hepatitis, Viral, Animal / Q000473:pathology / Q000821:virology*; D008099:Liver / Q000473:pathology / Q000648:ultrastructure / Q000821:virology; D008854:Microscopy, Electron / Q000662:veterinary; D009500:Neutralization Tests / Q000662:veterinary; D010490:Pericardial Effusion / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D011201:Poultry Diseases / Q000473:pathology / Q000821:virology*; D013577:Syndrome