title: Deleterious iron-mediated oxidation of biomolecules.
abstract: Iron is an essential metal for most biological organisms. However, if not tightly controlled, iron can mediate the deleterious oxidation of biomolecules. This review focuses on the current understanding of the role of iron in the deleterious oxidation of various biomolecules, including DNA, protein, lipid, and small molecules, e.g., ascorbate and biogenic amines. The effect of chelation on the reactivity of iron is also addressed, in addition to iron-associated toxicities. The roles of the iron storage protein ferritin as both a source of iron for iron-mediated oxidations and as a mechanism to safely store iron in cells is also addressed.
authors.affiliation: Department of Chemistry and Biochemistry, Biotechnology Center, Utah State University, Logan, UT, USA
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Welch
authors.forename: T Zane
authors.initials: TZ
authors.lastname: Davis
authors.forename: Marc E
authors.initials: ME
authors.lastname: Van Eden
authors.forename: Steven D
authors.initials: SD
authors.lastname: Aust
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005293:Ferritins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000502:physiology*; D050356:Lipid Metabolism; D046911:Macromolecular Substances; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism
chemical_list: D046911:Macromolecular Substances; D011506:Proteins; D004247:DNA; D005293:Ferritins; D007501:Iron; D001205:Ascorbic Acid