Antitumor agents. Part 3: synthesis and cytotoxicity of new trans-stilbene benzenesulfonamide derivatives.
A new series of trans-stilbene benzenesulfonamide derivatives were designed and synthesized as potential antitumor agents. These new compounds were evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. Compounds 9-13 were cytotoxic against several cell lines. Notably, two compounds, 9 and 12, demonstrated selective cytotoxic activity against BT-549 breast cancer (GI(50)=0.205 microM) and HT-29 colon cancer (GI(50)=0.554 microM), respectively.
Yang
Li-Ming
LM
Division of Medicinal Chemistry, National Research Institute of Chinese Medicine, 155-1, Li-Nong St., Sec. 2, Taipei 112, Taiwan. lmyang@cma23.nricm.edu.tw
Lin
Shwu-Jiuan
SJ
Hsu
Fen-Lin
FL
Yang
Tsang-Hsiung
TH
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity*; D001554:Benzene / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D013267:Stilbenes / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000633:toxicity*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000970:Antineoplastic Agents; D013267:Stilbenes; D013449:Sulfonamides; D001554:Benzene; C025906:stilbene oxide