title: [Histopathological diagnosis of celiac disease in children and adults: 3 years' experience].
abstract: We describe our personal experience with the routine histopathologic diagnosis of coeliac disease in pediatric and adult ages, over a period of 3 years. The most important indications based on the examination of over 300 cases include: (a) the importance of a correct orientation of biopsies on Millipore filters; (b) the not regular sending of clinical and laboratory results; (c) the better correspondence of modified Marsh classification by Oberhuber to the histologic characteristics of the disease before and after dieting; and (d) the increasing incidence of coeliac disease in adult age, even though in this case series the age-class most affected was that under 11 years (75 cases, 25%).
authors.affiliation: 2o Servizio di Anatomia ed Istologia Patologica, Spedali Civili, Piazzale Spedali Civili 1, I-25100 Brescia, Italia. villan@iol.it
authors.forename: V
authors.initials: V
authors.lastname: Villanacci
authors.forename: G
authors.initials: G
authors.lastname: Cornolti
authors.forename: F
authors.initials: F
authors.lastname: Lanzarotto
authors.forename: M
authors.initials: M
authors.lastname: Amato
authors.forename: N
authors.initials: N
authors.lastname: Pillan
authors.forename: A
authors.initials: A
authors.lastname: Ravelli
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D015415:Biomarkers; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis* / Q000178:diet therapy / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004947:Esophagus / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005903:Gliadin / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D006965:Hyperplasia; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D007223:Infant; D007249:Inflammation; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D011503:Transglutaminases / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D006680:HLA Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin; D011503:Transglutaminases