Hereditary premenopausal breast cancer.
Less than 1% of breast cancers occur between the age of 20 and 30 years, but more than 50% of breast cancers under the age of 30 years are hereditary. Breast cancer mainly occurs sporadically, however, in 5 to maximally 10% of cases a genetic predisposition is present. Mutations in the already sequenced tumor suppressor genes BRCA1 and BRCA2 account for 60-70% of these hereditary breast cancers. The chromosomal location of BRCA1 is 17q21 and that of BRCA2 is 13q12-13. Screening procedures and possible prevention strategies for women with mutations in the BRCA1 and BRCA2 genes are discussed. They include the use of tamoxifen.
Strobel
E-S
ES
Paracelsus-Klinik, Bad Elster, Germany.
Fritschka
E
E
D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics* / Q000517:prevention & control; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D015413:Mastectomy, Simple; D017697:Premenopause; D011379:Prognosis; D013629:Tamoxifen / Q000008:administration & dosage
D013629:Tamoxifen