New-onset seizure associated with quetiapine and olanzapine.
OBJECTIVE
To report a case involving a witnessed seizure in a patient receiving concurrent olanzapine and quetiapine.


METHODS
A 27-year-old white woman was observed to have a seizure while receiving a stable dosage of olanzapine 15 mg/d, with the addition of quetiapine 100 mg in the evening 1 day before the occurrence of the seizure. There were no known risk factors for epilepsy.


CONCLUSIONS
This case reports a new-onset seizure in the context of concurrent olanzapine and quetiapine use. Interpretation is complicated by recent discontinuation of low-dose clonazepam.


CONCLUSIONS
While uncommon, seizures can occur with non-clozapine atypical antipsychotics. Caution is indicated when using these drugs with other agents that may lower the seizure threshold.
Hedges
Dawson W
DW
Department of Psychology and the Neuroscience Center, Brigham Young University, Provo, UT, USA.
Jeppson
Kreg G
KG
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines; D003987:Dibenzothiazepines / Q000009:adverse effects*; D005260:Female; D006801:Humans; D000077152:Olanzapine; D010890:Pirenzepine / Q000009:adverse effects* / Q000031:analogs & derivatives; D000069348:Quetiapine Fumarate; D012559:Schizophrenia / Q000188:drug therapy*; D012640:Seizures / Q000139:chemically induced*
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; D010890:Pirenzepine; D000077152:Olanzapine