[Morphological and immunohistochemical characteristics of primary brain lymphomas in AIDS patients].
Primary lymphomas of the brain were studied in 6 AIDS patients. The lymphomas were characterized by multicentricity, extended necroses and location in large hemispheres. Two types of tumor cell growth were recorded: diffuse and perivascular with vascular wall destruction. According to the International Histologic Classification (2001), these lymphomas were classified as diffuse B-cell large cell lymphomas subdivided into 3 variants: immunoblastic with plasma cell differentiation, centroblastic polymorphic and large cell anaplastic (by Kils classification criteria). Immunohistochemically (LMP-1) and by hybridization in situ (RNA EBER-1,2) Epstein-Barr virus was found in tumor cells from all the patients. In 5 of 6 cases studied expression of the antiapoptotic protein bcl-2 and in 2 cases expression of mutant p53 were revealed.
Leenman
E E
EE
N.N. Petrov Cancer Research Institute, 186646, St-Petersburg.
Tsinzerling
V A
VA
Pozharisskiĭ
K M
KM
D000328:Adult; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D001932:Brain Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D016483:Lymphoma, AIDS-Related / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D014408:Biomarkers, Tumor