Soluble Fas and soluble Fas L levels in patients with acute pancreatitis.
The FasL-Fas system is an apoptosis induction system and plays an important role in homeostasis and biophylaxis. The present study was conducted to investigate soluble Fas (sFas), soluble Fas ligand (sFasL), and tumor necrosis factor alpha (TNF-alpha) in patients with acute pancreatitis. As acute pancreatitis became severe, the levels of sFas in the serum increased significantly, while those of sFasL decreased significantly. A significant inverse correlation was observed between the serum levels of sFas and those of sFasL. Also, a significant positive correlation was observed between the levels of TNF-alpha and sFas. A greater increase in serum sFas and decrease in serum sFasL levels was observed in patients with complicating multiple organ dysfunction syndrome (MODS) than in those without it. The results of the study suggest that the pathological aggravation of acute pancreatitis could be related to changes in the Fas-FasL system.
Endo
S
S
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Inoue
Y
Y
Fujino
Y
Y
Yamada
Y
Y
Sato
N
N
Wakabayashi
G
G
Sakamoto
T
T
Ishikura
H
H
Tanaka
T
T
Inada
K
K
Sato
S
S
D000208:Acute Disease; D000328:Adult; D000368:Aged; D017209:Apoptosis; D053222:Fas Ligand Protein; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000209:etiology / Q000473:pathology; D010195:Pancreatitis / Q000097:blood* / Q000150:complications / Q000473:pathology; D012995:Solubility; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D019014:fas Receptor / Q000097:blood*
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor