title: Color test for the detection of resin-bound aldehyde in solid-phase combinatorial synthesis.
abstract: We report the development of a sensitive and specific color test for the detection of the presence of resin-bound aldehyde groups using 4-amino-3-hydrazino-5-mercapto-1,2,4-triazole (Purpald). Aldehyde resin turns dark-brown to purple after a 5 min reaction followed by a 10 min air oxidation period. Resins that possess other functional groups (i.e., ketone, ester, amide, alcohol, and carboxylic acid) do not change color under the same conditions. The detection limit is 20 micromol/g for polystyrene-based aldehyde resins.
authors.affiliation: ChemRx Advanced Technologies, 385 Oyster Point Boulevard, South San Francisco, California 94080, USA.
authors.forename: Jason J
authors.initials: JJ
authors.lastname: Cournoyer
authors.forename: Tushar
authors.initials: T
authors.lastname: Kshirsagar
authors.forename: Pascal P
authors.initials: PP
authors.lastname: Fantauzzi
authors.forename: Gianine M
authors.initials: GM
authors.lastname: Figliozzi
authors.forename: Taline
authors.initials: T
authors.lastname: Makdessian
authors.forename: Bing
authors.initials: B
authors.lastname: Yan