title: Patient acceptance and reliability of new Humulin/Humalog 3.0 ml prefilled insulin pen in ten Croatian diabetes centres.
abstract: BACKGROUND
  The objective of this study was to assess feature preferences, patient acceptance, reliability, and safety of the new Lilly Humulin/Humalog 3.0 ml prefilled insulin pen in a clinical setting.
  
  
  METHODS
  A total of 330 patients in Croatia with type 1 or type 2 diabetes mellitus who required at least one injection of insulin per day were treated with Humulin 30/70 or Humalog for 4 to 6 weeks using the new prefilled pen. Questionnaires concerning various aspects of the pen performance were administered at endpoint.
  
  
  RESULTS
  The features of the Lilly 3.0 ml pen device ranked most highly by patients (% of excellent or good ratings) were cartridge visibility (93%), attaching/replacing needles (93%), ease of dose correction (92%), checking insulin flow (90%) and dialling of insulin dose (89%). Features of the pen device rated most highly by patients in comparison with the delivery systems used before the study and the percentage of patients rating those features as much better or better were ease of dose correction (74%), cartridge visibility (67%), audible dialing clicks (55%) and size of dose numbers (52%). Most respondents (78%) preferred single-unit versus two-unit dosage increments. The majority of patients rated the new prefilled pen as being more convenient and easier to use, and indicated that it represented a significant or modest an improvement over their previous insulin injection method.
  
  
  CONCLUSIONS
  The results of this study indicate that the new Lilly 3.0 ml prefilled pen is acceptable for patients who were previously using either reusable devices or the traditional syringe and vial.
authors.affiliation: Clinical Hospital Dubrava, Zagrzeb, Croatia.
authors.forename: Mate
authors.initials: M
authors.lastname: Sucic
authors.forename: Eduard
authors.initials: E
authors.lastname: Galic
authors.forename: Tomislav
authors.initials: T
authors.lastname: Cabrijan
authors.forename: Ante
authors.initials: A
authors.lastname: Ivandic
authors.forename: Ante
authors.initials: A
authors.lastname: Petrusic
authors.forename: John
authors.initials: J
authors.lastname: Wyatt
authors.forename: Nadia
authors.initials: N
authors.lastname: Mincheva
authors.forename: Zvonko
authors.initials: Z
authors.lastname: Milicevic
authors.forename: James
authors.initials: J
authors.lastname: Malone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017523:Croatia; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004867:Equipment Design; D005260:Female; D006801:Humans; D007267:Injections / Q000295:instrumentation*; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010353:Patient Education as Topic; D017060:Patient Satisfaction; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D013594:Syringes
chemical_list: D007328:Insulin