Effect of dexamethasone on implantation and pregnancy in albino rats.
Administration of 3 mg/kg body weight of dexamethasone from day 1 or 3 to 7 of pregnancy did not prevent implantation in albino rats. But the same dose when administered from day 8 to 11 resulted in complete abortion / resorption in all rats. Administration of 2 mg / kg body weight of dexamethasone from day 8 to 11 of pregnancy held no effect on the foetal survival. The results indicate that a high dose of dexamethasone does not affect implantation but the same dose affects the more advanced stages of pregnancy.
Nevagi
S A
SA
Postgraduate Department of Studies in Zoology, Karnatak University, Dharwad, India.
Kaliwal
B B
BB
D000818:Animals; D003907:Dexamethasone / Q000633:toxicity*; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D005938:Glucocorticoids / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D005938:Glucocorticoids; D003907:Dexamethasone