Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains.
We identified a new type of staphylococcal cassette chromosome mec (SCCmec) from two community-acquired methicillin-resistant Staphylococcus aureus (MRSA) strains. The novel element, designated type IV SCCmec, had a unique combination of the class B mec gene complex and the type 2 ccr gene complex and was much smaller in size (21 to 24 kb) than previously identified SCCmec elements of hospital-acquired MRSA. Consistent with the strains' susceptibilities to various non-beta-lactam antibiotics, the type IV SCCmec was devoid of any antibiotic resistance genes other than the mecA gene.
Ma
Xiao Xue
XX
Department of Bacteriology, Juntendo University, Tokyo, Japan.
Ito
Teruyo
T
Tiensasitorn
Chuntima
C
Jamklang
Mantana
M
Chongtrakool
Piriyaporn
P
Boyle-Vavra
Susan
S
Daum
Robert S
RS
Hiramatsu
Keiichi
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D017714:Community-Acquired Infections / Q000382:microbiology*; D004269:DNA, Bacterial / Q000235:genetics; D016106:Methicillin Resistance / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics*
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial