title: Equine herpesvirus type 1 (EHV-1) myeloencephalopathy: a case report.
abstract: An outbreak of neurological disease occurred in a well-managed riding school. Ataxia and paresis were observed in several horses, five of which became recumbent and were euthanized. Post-mortem analysis revealed scattered haemorrhages along the spinal cord, that were reflected by multiple haemorrhagic foci on formalin-fixed sections, with the thoracic and lumbar segments being the most affected. Pathohistologically, perivascular mononuclear cuffing and axonal swelling, especially in the white matter, were evident. Parallel to the course of disease, alterations in myelin sheets and activation of astrocytes and microglial cells were also observed. Virological findings confirmed an acute equine herpesvirus type 1 infection and virus was isolated from the spinal cord of a 26-year-old mare.
authors.affiliation: Institute of Veterinary Pathology, Infectious and Epidemic Diseases, Ludwig-Maximilians-Universität München, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Stierstorfer
authors.forename: W
authors.initials: W
authors.lastname: Eichhorn
authors.forename: W
authors.initials: W
authors.lastname: Schmahl
authors.forename: C
authors.initials: C
authors.lastname: Brandmüller
authors.forename: O R
authors.initials: OR
authors.lastname: Kaaden
authors.forename: A
authors.initials: A
authors.lastname: Neubauer
mesh_terms: D000818:Animals; D001921:Brain / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D003937:Diagnosis, Differential; D004196:Disease Outbreaks / Q000662:veterinary*; D004679:Encephalomyelitis / Q000150:complications / Q000453:epidemiology / Q000662:veterinary*; D005260:Female; D005455:Fluorescent Antibody Technique / Q000662:veterinary; D020234:Gait Ataxia / Q000209:etiology / Q000662:veterinary*; D005858:Germany / Q000453:epidemiology; D006566:Herpesviridae Infections / Q000150:complications / Q000453:epidemiology / Q000662:veterinary*; D004861:Herpesvirus 1, Equid / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006734:Horse Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D006736:Horses; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D016133:Polymerase Chain Reaction / Q000662:veterinary; D013116:Spinal Cord / Q000821:virology
chemical_list: D004279:DNA, Viral