title: Yohimbine treatment of organic erectile dysfunction in a dose-escalation trial.
abstract: Yohimbine has had questionable effects in men with organic erectile dysfunction. We conducted this study to better define the population of men responsive to yohimbine, because tobacco was thought to affect a regimen of yohimbine more than other risk factors. We measured nocturnal penile tumescence with the RigiScan monitor, hormone profiles, answers to the Florida Sexual Health Questionnaire, and clinical responses at baseline and after two different doses of yohimbine in 18 nonsmoking men with erectile dysfunction. Of the 18 men, nine (50%) were successful in completing intercourse in more than 75% of attempts. The yohimbine responders were men with less severe erectile dysfunction as manifested by improved increased rigidity on RigiScan testing, higher Florida Sexual Health Questionnaire scores, and slightly higher levels of serum testosterone. Yohimbine is an effective therapy to treat organic erectile dysfunction in some men with erectile dysfunction.
authors.affiliation: Center for Sexual Function, Lahey Clinic Northshore, Peabody, Massachusetts 01960, USA. Andre.T.Guay@lahey.org
authors.forename: A T
authors.initials: AT
authors.lastname: Guay
authors.forename: R F
authors.initials: RF
authors.lastname: Spark
authors.forename: J
authors.initials: J
authors.lastname: Jacobson
authors.forename: F T
authors.initials: FT
authors.lastname: Murray
authors.forename: M E
authors.initials: ME
authors.lastname: Geisser
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002940:Circadian Rhythm; D003075:Coitus; D004305:Dose-Response Relationship, Drug; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000187:drug effects; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D015016:Yohimbine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000317:Adrenergic alpha-Antagonists; D015016:Yohimbine