title: The effect of short-duration, high-intensity electromagnetic pulses on fresh ulnar fractures in rats.
abstract: Pulsed electromagnetic fields (PEMFs) have been found to be beneficial to a wide variety of biological phenomena. In particular, PEMFs have been shown to be useful in the promotion of healing of ununited fractures. Conflicting information exists regarding the benefit of using PEMFs to accelerate the healing of fresh fractures. This paper reports on the evaluation of the effect of a new PEMF generator (PAP IMI) on the healing of fresh ulnar fractures in rats. This device is unique by virtue of the extremely high power output of each of the pulses it generates. Ulnar fractures were created in rats by using a bone cutter, thus producing a 2-3 mm bone defect. Rats were then randomly divided into treatment and control groups. The treatment group underwent periodic treatments with the PAP IMI, and the control group received no treatment. Radiographs of rats from both groups were taken at 1-week intervals. Histological evaluation was performed at the end of the study. Radiographic and histopathological evaluations were scored, and scores were used to assess both rate and quality of healing. The radiographic results demonstrated gradual bridging callus formation in both control and treatment groups, however, the healing process was faster in rats that were not treated by PEMF. Histological evaluation demonstrated that the fibrous content of the callus in rats belonging to the treatment group was significantly higher than that in rats belonging to the control group. The results of this study do not support the claim that PEMF generated by the PAP-IMI stimulate osteogenesis and bone healing after the creation of fresh ulnar fractures in rats.
authors.affiliation: Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovat, Israel. leisner@agri.huji.ac.il
authors.forename: S
authors.initials: S
authors.lastname: Leisner
authors.forename: R
authors.initials: R
authors.lastname: Shahar
authors.forename: I
authors.initials: I
authors.lastname: Aizenberg
authors.forename: D
authors.initials: D
authors.lastname: Lichovsky
authors.forename: T
authors.initials: T
authors.lastname: Levin-Harrus
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004574:Electromagnetic Fields; D017102:Fracture Healing; D008297:Male; D011859:Radiography; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome; D014458:Ulna Fractures / Q000000981:diagnostic imaging / Q000628:therapy*