Genetics of brain neoplasms.
Transformation of a normal cell into a malignant cell involves a series of events that damage the genome. Gliomas are the most common adult neoplasm of the central nervous system. To develop new therapeutic strategies requires an understanding of the specific lesions that occur and contribute to this malignant process. Initially, data reported from the analyses of human gliomas were quite variable. This has recently changed as more data have become available and the selection of tissue analyzed is coupled with clinical criteria. Specific genetic lesions are now defining different glioma pathways, and some aberrations may be indicative of therapeutic response. This review focuses on the specific genetic aberrations associated with astrocytic and oligodenroglial tumors.
Shapiro
J R
JR
Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA. jshapiro@chw.edu
D000293:Adolescent; D000328:Adult; D000368:Aged; D001253:Astrocytes / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002454:Cell Differentiation; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002877:Chromosomes, Human / Q000235:genetics / Q000648:ultrastructure; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D018450:Disease Progression; D005260:Female; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D005909:Glioblastoma / Q000235:genetics; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000235:genetics; D009836:Oligodendroglia / Q000473:pathology; D009837:Oligodendroglioma / Q000235:genetics* / Q000473:pathology; D017978:Receptors, Growth Factor / Q000235:genetics
D006133:Growth Substances; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D017978:Receptors, Growth Factor