Expression of cyclic adenosine monophosphate response-element binding protein in acute leukemia.
Cyclic adenosine monophosphate response-element binding protein (CREB) is a nuclear protein that regulates expression of genes that control cell proliferation, differentiation, and survival. To analyze CREB expression in leukemia cells, we conducted Western blot analysis of bone marrow cells obtained from patients with acute lymphoblastic leukemia, patients with acute myeloid leukemia, and patients without active leukemia. CREB was expressed at a higher frequency in bone marrow cells from patients with acute lymphoid or myeloid leukemia than in patients with leukemia remission or without leukemia. Our results indicate that CREB expression could be a useful marker for leukemia in patients with acute disease and suggest a role for CREB in leukemogenesis.
Crans-Vargas
Heather N
HN
Department of Pediatrics, Division of Hematology-Oncology, Gwynne-Hazen Cherry Memorial Laboratories, University of California Los Angeles (UCLA), Los Angeles, CA 90095-2752, USA.
Landaw
Elliot M
EM
Bhatia
Smita
S
Sandusky
George
G
Moore
Theodore B
TB
Sakamoto
Kathleen M
KM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015153:Blotting, Western; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism* / Q000473:pathology; D012016:Reference Values
D017362:Cyclic AMP Response Element-Binding Protein