Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels.
Shanley
Lynne J
LJ
Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
Irving
Andrew J
AJ
Rae
Mark G
MG
Ashford
Mike L J
ML
Harvey
Jenni
J
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D002478:Cells, Cultured; D018999:Charybdotoxin / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D051037:Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; D020738:Leptin / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018408:Patch-Clamp Techniques; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D024681:Potassium Channels, Calcium-Activated / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D019789:Tetraethylammonium / Q000494:pharmacology; D014044:Tolbutamide / Q000494:pharmacology
D002118:Calcium; D002352:Carrier Proteins; D018999:Charybdotoxin; D051037:Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; D020738:Leptin; D019869:Phosphatidylinositol 3-Kinases; D024681:Potassium Channels, Calcium-Activated; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D019789:Tetraethylammonium; D014044:Tolbutamide; C494842:Kcnma1 protein, rat; C515448:LEPR protein, human