Nucleotides as semiessential nutritional components.
Dietary nucleotides are required nutrients for some tissues under certain circumstances. A lack of dietary nucleotides negatively influences protein synthesis in both the liver and the small intestine of rats. Ribosome degradation has been observed as being among the mechanisms responsible for this effect. Dietary nucleotides can also modulate gene expression by interaction with specific transcription factors, in both the liver and the small intestine.
Sánchez-Pozo
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Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Granada, Spain. sanchezp@platon.ugr.es
Gil
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D004032:Diet; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D009711:Nucleotides / Q000494:pharmacology*; D009747:Nutritional Physiological Phenomena; D014176:Protein Biosynthesis
D009711:Nucleotides