Chronic parvovirus B19 infection in a pediatric lung transplanted patient.
In immunocompromised patients, clinical manifestations of human parvovirus B19 (PVB19) infection are mostly reported as acute or chronic hematological disorders. Recently, PVB19 infection has been associated with nonhematological symptoms. Four years after lung transplantation, a 9-year-old girl developed a severe anemia with reticulocytopenia requiring blood transfusion. PVB19 DNA was found by polymerase chain reaction in blood. Blood marrow aspiration revealed typical features of PVB19 infection. She was successfully treated with high dose of i.v. Ig. Then, she exhibited recurrent nonregenerative anemia requiring another course of i.v. Ig. PVB19 DNA has been persisted in blood with no specific immune response. At the same time, she suffered from several lung infection syndromes with no microorganism found except PVB19 DNA. Recurrent mild renal dysfunction was noticed with no other explanation than PVB19 infection. This report indicates that pediatric transplanted patients are at risk of chronic PVB19 infection, which can be associated with lung and/or renal disorders.
Moreux
Nathalie
N
Unité de Pneumologie Pédiatrique, Allergologie et Mucoviscidose, Centre Hospitalier Lyon Sud, 69495 Pierre Bénite, Cedex, France.
Ranchin
Bruno
B
Calvet
Agnès
A
Bellon
Gabriel
G
Levrey-Hadden
Hélène
H
D000328:Adult; D000740:Anemia / Q000188:drug therapy / Q000209:etiology; D000900:Anti-Bacterial Agents; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D002908:Chronic Disease; D004279:DNA, Viral / Q000097:blood; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000473:pathology*; D010322:Parvoviridae Infections / Q000175:diagnosis*; D016732:Parvovirus B19, Human / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D011183:Postoperative Complications / Q000175:diagnosis*
D000900:Anti-Bacterial Agents; D004279:DNA, Viral