title: Cytokeratin-derived markers of lung cancer.
abstract: Various evaluation methods are available for aiding clinicians in lung cancer management. Some of these methods are highly specific. However, they are also invasive and burdened by non-negligible complication rates (e.g., mediastinoscopy); other methods are highly accurate and noninvasive, but require expensive equipment and well-trained personnel (e.g., PET scanning); others are fast, inexpensive and safe. However, their diagnostic yield is low and requires further clinical testing (an example of such tests is the chest-x-ray film). There is probably only one way to perform an easy, inexpensive, repeatable test, which is also fairly accurate and predictive. This is tumor marker testing, which--as a large and specialized literature shows--can be highly effective when based on a cytokeratin-derived marker assay.
authors.affiliation: Divisione di Pneumologia, Ospedale S. Croce e Carle, Cuneo, I-12100, Italy. buccheri@culcasg.org
authors.forename: G
authors.initials: G
authors.lastname: Buccheri
authors.forename: D
authors.initials: D
authors.lastname: Ferrigno
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics*; D014408:Biomarkers, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D053539:Keratin-19; D007633:Keratins / Q000235:genetics*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D025202:Molecular Diagnostic Techniques; D012680:Sensitivity and Specificity
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D053539:Keratin-19; C102012:antigen CYFRA21.1; D007633:Keratins