Oral tolerance and gut-oriented immune response to dietary proteins.
Dietary proteins induce both a local immune response characterized by IgA production and systemic immune response characterized by the production of TH2/TH3 cytokines. By influencing the class of immune response, the gut enhances the efficacy of immunity against proteins that enter the body through the diet while, at the same time, ensuring its own safety. This article reviews and summarizes the field of "oral tolerance," with emphasis on recent advancements.
Alpan
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Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 111, 9000 Rockville Pike, Bethesda, MD 20850, USA. oalpan@niaid.nih.gov
D000818:Animals; D000941:Antigens / Q000276:immunology; D004044:Dietary Proteins / Q000276:immunology*; D004064:Digestive System / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance
D000941:Antigens; D004044:Dietary Proteins