Absence of HMGIC-LHFP fusion in pulmonary chondroid hamartomas with aberrations involving chromosomal regions 12q13 through 15 and 13q12 through q14.
In a variety of benign solid human tumors the high mobility group protein gene HMGIC is affected by aberrations involving the chromosomal region 12q14 through q15. Beside the two predominant alterations t(3;12) (q27 through 28;q14 through q15) and t(12;14)(q14 through q15;q23 through q24), the t(12;13)(q14 through q15;q12 through q14) is another aberration observed recurrently in these tumors. Very recently, an HMGIC-LHFP (lipoma HMGIC fusion partner) fusion gene has been detected in a lipoma with a t(12;13). The results of the present study demonstrated the absence of the HMGIC-LHFP fusion in three pulmonary chondroid hamartomas (PCH) with complex aberrations involving chromosomal regions 12q13 through q15 and 13q12q through q14 and one PCH with a simple t(12;13)(q14 through 15;q13) by reverse transcription-polymerase chain reaction. Thus, intragenic rearrangements within the LHFP gene leading to its fusion to HMGIC are not a consistent finding in mesenchymal tumors with clonal aberrations of both chromosomal regions 12q13 through q15 and 13q12 through q14.
Rogalla
Piere
P
Center of Human Genetics, University of Bremen, Leobenerstr. ZGH, D-28359, Breman, Germany.
Lemke
Inga
I
Bullerdiek
Jörn
J
D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D002882:Chromosomes, Human, Pair 13; D003598:Cytoskeletal Proteins / Q000235:genetics; D025743:HMGA2 Protein / Q000235:genetics; D006222:Hamartoma / Q000235:genetics*; D006801:Humans; D060588:LIM Domain Proteins; D008175:Lung Neoplasms / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics
D003598:Cytoskeletal Proteins; D025743:HMGA2 Protein; D060588:LIM Domain Proteins; C103594:LPP protein, human; D015514:Oncogene Proteins, Fusion