"Meshed-Bag Gathered-Bunch" method for solid-phase synthesis of small molecular diverse compounds.
A new "Meshed-Bag Gathered-Bunch" technology for the solid-phase synthesis of chemical libraries was developed. Using such technology, we synthesized muramyl dipeptide mimetics including derivatives at the N- and C-terminus, cyclic muramyl dipeptide mimetics, muramyl dipeptide and Tuftsin's analogue conjugates. The advantages of such a method include ease of manufacture, low unit cost of production, the physical encoding method, and the compatibility with both parallel and "split-mix" approaches.
Zhang
Suo-De
SD
Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, China.
Liu
Gang
G
Xia
Shu-Quan
SQ
Wu
Ping
P
Zhang
Liang
L
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D009842:Oligopeptides / Q000138:chemical synthesis*; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D014405:Tuftsin / Q000031:analogs & derivatives*
D009842:Oligopeptides; D010456:Peptides, Cyclic; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D014405:Tuftsin