title: [A case of cerebellar degeneration with schizophrenia-like psychosis, severe iron deficiency, hypoceruloplasminemia and abnormal electroretinography: a new syndrome?].
abstract: A 33-year-old male patient began to develop schizophrenia-like symptoms and slowly progressive cerebellar ataxia. He was 170 cm tall and he had mild frontal baldness. Psychiatrically he was aconative, only willing to do nothing all day long after admission. He had neither hallucinations nor delusions, and his mental acuity was normal. Neurological examination revealed positive cerebellar signs including clumsiness in F-N-T and K-H-T and dysdiadochokinesis. He could neither stand up nor walk because of ataxia. The brain MRI showed severe cerebellar atrophy with normal basal ganglia. His EEG and the value of NCV were within normal range, whereas electroretinography showed a notable abnormality, pointing to the extremely small b-wave, resulting in a negative shape of the ERG. Although he was eating sufficiently, the level of serum iron and ferritin remained constantly low. The serum copper level was within normal range, whereas the serum ceruloplasmin level was mildly decreased. A hepatic biopsy indicated no accumulation of copper or iron. This case suggests the importance of the investigation of the serum iron and ceruloplasmin levels in patients who have cerebellar degeneration with psychosis.
authors.affiliation: Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry.
authors.forename: A
authors.initials: A
authors.lastname: Kimura
authors.forename: H
authors.initials: H
authors.lastname: Yoshino
authors.forename: T
authors.initials: T
authors.lastname: Yuasa
mesh_terms: D000328:Adult; D002570:Ceruloplasmin / Q000172:deficiency*; D004596:Electroretinography; D006801:Humans; D000090463:Iron Deficiencies; D008297:Male; D012164:Retinal Diseases / Q000150:complications / Q000175:diagnosis; D012559:Schizophrenia / Q000209:etiology*; D013132:Spinocerebellar Degenerations / Q000150:complications* / Q000175:diagnosis; D013577:Syndrome
chemical_list: D002570:Ceruloplasmin