title: Effectiveness of combined blood conservation measures in thoracic aortic operations with deep hypothermic circulatory arrest.
abstract: BACKGROUND
  The effectiveness of blood conservation measures for thoracic aortic operations with deep hypothermic circulatory arrest has not yet been documented.
  
  
  METHODS
  From July 1997 to December 2000, 148 thoracic aortic operations were performed in our department. Sixty-one cases involving patients who underwent elective thoracic aortic operation with deep hypothermic circulatory arrest were reviewed retrospectively.
  
  
  RESULTS
  Seventeen patients did not meet the criteria for the blood conservation program and were excluded from the present study. Therefore, 44 patients were analyzed in this study. Overall, 50% of patients did not require operative homologous blood transfusion (HBT) and 43% did not require in-hospital HBT. Smaller amounts of autologous donation, greater blood loss, and a longer operation time were independent risk factors for HBT requirement. Among 16 patients who had made an autologous donation of 1,600 mL or greater, 75% did not require intraoperative HBT and 69% did not require in-hospital HBT. The overall perioperative mortality rate was 4.5%. As for postoperative complications, prolonged intubation and postoperative infection were significantly more frequent among patients who required in-hospital HBT.
  
  
  CONCLUSIONS
  Our combined blood conservation measures were effective in avoiding HBT during major thoracic aortic operations with deep hypothermic circulatory arrest and may have reduced postoperative complications. The amount of the autologous donation was a strong predictor for avoiding HBT.
authors.affiliation: Department of Cardiothoracic Surgery, University of Tokyo, Japan. shibata-tho@h.u-tokyo.ac.jp
authors.forename: Ko
authors.initials: K
authors.lastname: Shibata
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takamoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kotsuka
authors.forename: Hajime
authors.initials: H
authors.lastname: Sato
mesh_terms: D000368:Aged; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D001804:Blood Transfusion, Autologous; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D005260:Female; D006324:Heart Arrest, Induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies