The brain and salt-sensitive hypertension.
Genetically salt-sensitive rats, such as Dahl S and spontaneously hypertensive rats, show clear hypertensive responses to a high salt diet. Neural mechanisms play an essential role in salt-induced hypertension, and recent studies indicate that centrally induced sympathetic hyperactivity actually causes the hypertension. This review discusses the view that the renal genotype is not the only determinant of salt-induced sympathetic hyperactivity and hypertension, and that changes in genetic control of neuronal responses to cerebrospinal fluid Na(+) may play a primary role.
Leenen
Frans H H
FH
Hypertension Unit, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada. fleenen@ottawaheart.ca
Ruzicka
Marcel
M
Huang
Bing S
BS
D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects / Q000503:physiopathology; D005192:Family Health; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000235:genetics / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects; D051381:Rats; D020303:Rats, Inbred Dahl; D012982:Sodium, Dietary / Q000009:adverse effects* / Q000494:pharmacology*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology
D012982:Sodium, Dietary