title: Retinoblastoma in older children.
abstract: OBJECTIVE
  Retinoblastoma (RB) is known to present with atypical signs and symptoms in older patients. Our article reviews the clinical and histopathological features of RB encountered in children older than 5 years of age.
  
  
  METHODS
  A total of 337 consecutive patients with RB were reviewed. Eighteen (5.3%; 10 males, 8 females) who presented after the age of 5 were selected for further analysis of clinical data and histopathological material in this retrospective, non-comparative case series.
  
  
  RESULTS
  The age range was from 5 to 12 years (mean age 6.4). Unilateral disease was seen in 14 children, bilateral disease in 4 children. Eleven children were the product of consanguineous marriages. Seven patients had leukocoria; the others presented with signs of uveitis, cellulitis, and/or trauma. Three patients had flat, plaque-like lesions on histopathologic evaluation.
  
  
  CONCLUSIONS
  Clinical and histopathologic features were atypical in 47% and 21% respectively in the retinoblastoma patients who presented after the age of 5 years.
authors.affiliation: King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Zeynel A
authors.initials: ZA
authors.lastname: Karcioglu
authors.forename: Emad B
authors.initials: EB
authors.lastname: Abboud
authors.forename: Saleh A
authors.initials: SA
authors.lastname: Al-Mesfer
authors.forename: Waleed
authors.initials: W
authors.lastname: Al-Rashed
authors.forename: Delia H
authors.initials: DH
authors.lastname: Pilapil
mesh_terms: D002648:Child; D002675:Child, Preschool; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D008297:Male; D019572:Retinal Neoplasms / Q000473:pathology* / Q000601:surgery; D012175:Retinoblastoma / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies