title: Long-term intrathecal Baclofen infusion in supraspinal spasticity of adulthood.
abstract: OBJECTIVE
  To evaluate long-term results of chronic intrathecal Baclofen infusion on the spasticity, on the spasms and to evaluate the side-effects of the intrathecal Baclofen in patients with supraspinal spasticity.
  
  
  METHODS
  Fourteen patients with severe progressive refractory to medical therapy spasticity were evaluated after chronic intrathecal Baclofen infusion performed by implantation of subcutaneous pump. The patients had suffered traumatic or anoxic acquired brain injuries. The clinical evaluation was made using Ashworth Scale (AS) and the Spasm Frequency Scale (SFS).
  
  
  RESULTS
  The intrathecal therapy showed a statistically significant improvement of the tone and of the spasms.
  
  
  CONCLUSIONS
  The intrathecal infusion of Baclofen seems to be an effective treatment in patients with supraspinal spasticity.
authors.affiliation: Department of Neurosurgery, University of Insubria, Italy. dario.alessandro@virgilio.it
authors.forename: A
authors.initials: A
authors.lastname: Dario
authors.forename: M G
authors.initials: MG
authors.lastname: Di Stefano
authors.forename: A
authors.initials: A
authors.lastname: Grossi
authors.forename: F
authors.initials: F
authors.lastname: Casagrande
authors.forename: G
authors.initials: G
authors.lastname: Bono
mesh_terms: D000293:Adolescent; D000328:Adult; D001418:Baclofen / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D001930:Brain Injuries / Q000150:complications; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D002534:Hypoxia, Brain / Q000150:complications; D015918:Infusion Pumps, Implantable; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D013035:Spasm / Q000188:drug therapy* / Q000209:etiology; D013122:Spinal Diseases / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors
chemical_list: D001418:Baclofen