Bone marrow stem cell and progenitor response to injury.
Hematopoietic stem cells represent a long term reservoir of cells to populate blood with multiple formed cells. These hematopoietic stem cells proliferate and mature into lymphoid, erythroid, and myeloid precursor cells, with the balance of these cell populations modulated by major thermal injury, with or without sepsis. Recent studies indicate that thermal injury shifts this balance to favor the monocyte/macrophage lineage at the expense of neutrophil production. The mechanisms for these changes are now being elucidated with the results of clinical importance, because understanding the dynamics of the different precursor pools could be used to identify patients at greater risk for systemic inflammatory sequelae following major thermal injury.
Silva
K D
KD
Department of Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA.
Gamelli
R L
RL
Shankar
R
R
D002056:Burns / Q000503:physiopathology*; D019070:Cell Lineage; D005334:Fever / Q000503:physiopathology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007958:Leukocyte Count; D008264:Macrophages / Q000502:physiology; D009504:Neutrophils / Q000502:physiology; D018805:Sepsis / Q000503:physiopathology
D016178:Granulocyte-Macrophage Colony-Stimulating Factor