title: Deuterium structural effects in inorganic and bioinorganic aggregates.
abstract: Deuterium kinetic isotope effects are widely used in chemical and biological research. Deuterium thermodynamic effects on the aqueous synthesis of inorganic materials, however, seem not to have been recognized. Here we report that the simple replacement of H(2)O with D(2)O in the synthesis of a solid-state manganese complex results in a new structurally and magnetically distinct phase. When iron oxides are synthesized, the relative amount of the mineral phases obtained in H(2)O vs D(2)O is different. The morphology and magnetic properties of the iron core of the iron storage protein ferritin are likewise different when mineralization is carried out in heavy water. The formation of extra inorganic solids, change in the ratio of two phases or alteration of a single phase morphology in D(2)O suggest that new inorganic and bioinorganic metal complexes might be obtained by using the thermodynamic isotope effect.
authors.affiliation: Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
authors.forename: Jaeho
authors.initials: J
authors.lastname: Lee
authors.forename: N Dennis
authors.initials: ND
authors.lastname: Chasteen
authors.forename: Guanghua
authors.initials: G
authors.lastname: Zhao
authors.forename: Georgia C
authors.initials: GC
authors.lastname: Papaefthymiou
authors.forename: Sergiu M
authors.initials: SM
authors.lastname: Gorun
mesh_terms: D003903:Deuterium / Q000737:chemistry*; D017666:Deuterium Oxide / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry*; D005293:Ferritins / Q000737:chemistry*; D007700:Kinetics; D008345:Manganese / Q000737:chemistry*; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry*; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D005290:Ferric Compounds; D009942:Organometallic Compounds; D014867:Water; C000499:ferric oxide; D008345:Manganese; D005293:Ferritins; D003903:Deuterium; D017666:Deuterium Oxide