title: fMRI/EEG in paroxysmal activity elicited by elimination of central vision and fixation.
abstract: Using functional MRI (fMRI) with concurrent EEG monitoring the authors studied cortical activation associated with epileptiform discharges in three patients with fixation-off sensitivity. The EEG paroxysmal activity elicited by eliminating central vision correlated significantly with an increased blood oxygen level-dependent signal in the extrastriate cortex (Brodmann areas 19 and 37). fMRI provides a unique opportunity for localizing precisely the cortical areas generating paroxysmal activity in patients with fixation-off sensitivity.
authors.affiliation: Department of Neurological Sciences, University of Rome "La Sapienza," Pozzilli, Italy. giandomenico.iannetti@uniroma1.it
authors.forename: G D
authors.initials: GD
authors.lastname: Iannetti
authors.forename: C
authors.initials: C
authors.lastname: Di Bonaventura
authors.forename: P
authors.initials: P
authors.lastname: Pantano
authors.forename: A T
authors.initials: AT
authors.lastname: Giallonardo
authors.forename: P L
authors.initials: PL
authors.lastname: Romanelli
authors.forename: L
authors.initials: L
authors.lastname: Bozzao
authors.forename: M
authors.initials: M
authors.lastname: Manfredi
authors.forename: G B
authors.initials: GB
authors.lastname: Ricci
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D003941:Diagnostic Techniques, Ophthalmological; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D014786:Vision Disorders / Q000175:diagnosis / Q000503:physiopathology*; D015357:Vision Disparity / Q000502:physiology*; D014785:Vision, Ocular