Actin' up: RhoB in cancer and apoptosis.
RhoB is a small GTPase that regulates actin organization and vesicle transport. It is required for signalling apoptosis in transformed cells that are exposed to farnesyltransferase inhibitors, DNA-damaging agents or taxol. Genetic analysis in mice indicates that RhoB is dispensable for normal cell physiology, but that it has a suppressor or negative modifier function in stress-associated processes, including cancer.
Prendergast
G C
GC
The DuPont Pharmaceuticals Company, Glenolden Laboratory, Pennsylvania 19004, USA. george.c.prendergast@dupontpharma.com
D000199:Actins / Q000378:metabolism*; D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors / Q000502:physiology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D004249:DNA Damage; D004790:Enzyme Induction; D004791:Enzyme Inhibitors / Q000494:pharmacology; D051231:Farnesyltranstransferase; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D051379:Mice; D005810:Multigene Family; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D017239:Paclitaxel / Q000494:pharmacology; D017368:Protein Prenylation / Q000187:drug effects; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D015398:Signal Transduction / Q000502:physiology; D013312:Stress, Physiological / Q000235:genetics / Q000378:metabolism; D018631:ras Proteins / Q000037:antagonists & inhibitors; D020743:rhoB GTP-Binding Protein / Q000502:physiology*
D000199:Actins; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D009363:Neoplasm Proteins; D006160:Guanosine Triphosphate; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I; D051231:Farnesyltranstransferase; D018631:ras Proteins; D020743:rhoB GTP-Binding Protein; D017239:Paclitaxel