Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum.
Six new xanthones, cratoxyarborenones A-F (1-6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and delta-tocotrienol, were obtained as inactive constituents.
Seo
Eun-Kyoung
EK
Chemistry and Life Sciences Group, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709, USA.
Kim
Nam-Cheol
NC
Wani
Mansukh C
MC
Wall
Monroe E
ME
Navarro
Hernán A
HA
Burgess
Jason P
JP
Kawanishi
Kazuko
K
Kardono
Leonardus B S
LB
Riswan
Soedarsono
S
Rose
William C
WC
Fairchild
Craig R
CR
Farnsworth
Norman R
NR
Kinghorn
A Douglas
AD
D000818:Animals; D000873:Anthracenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007214:Indonesia; D007624:KB Cells / Q000187:drug effects; D007941:Leukemia P388; D051379:Mice; D008811:Mice, Inbred DBA; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification*; D044004:Xanthones
C455299:2,4,6-trihydroxybenzophenone 4-O-geranyl ether; D000873:Anthracenes; D000880:Anthraquinones; D001577:Benzophenones; D014966:Xanthenes; D044004:Xanthones; C455129:cratoxyarborequinone A; C455130:cratoxyarborequinone B; C455128:vismione B; D014810:Vitamin E; C082097:tocotrienol, delta; C009689:xanthone