title: Dermatological manifestations of Down's syndrome.
abstract: BACKGROUND
  Down's syndrome (DS) is an extensively researched congenital condition characterized by mental retardation and distinct physical features. The cutaneous manifestations of DS are numerous, yet they seldom receive appropriate attention.
  
  
  OBJECTIVE
  To review the dermatological conditions associated with DS.
  
  
  METHODS
  A review of the medical literature.
  
  
  RESULTS
  DS is associated with an increased incidence of numerous dermatological conditions, some of which may be related to an immunological deficiency.
  
  
  CONCLUSIONS
  Along with the importance of understanding the physical and psychosocial aspects of DS, an appreciation of the dermatological manifestations of this condition is integral to comprehensive medical care.
authors.affiliation: The University of Western Ontario, 835 Richmond Street, London, Ontario, Canada N6A 3H7.
authors.forename: B
authors.initials: B
authors.lastname: Barankin
authors.forename: L
authors.initials: L
authors.lastname: Guenther
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000506:Alopecia Areata / Q000453:epidemiology; D002613:Cheilitis / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000453:epidemiology; D004314:Down Syndrome / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008423:Maternal Age; D014009:Onychomycosis / Q000453:epidemiology; D011565:Psoriasis / Q000453:epidemiology; D012737:Sex Factors; D015595:Skin Aging; D012871:Skin Diseases / Q000453:epidemiology* / Q000209:etiology; D014008:Tinea Pedis / Q000453:epidemiology; D014063:Tongue, Fissured / Q000453:epidemiology; D014820:Vitiligo / Q000453:epidemiology