title: Human lymphocyte antigen DR7 protects against proliferative retinopathy with type II diabetes mellitus.
abstract: BACKGROUND
  This study was undertaken in order to analyze the genetic incidence of human lymphocyte antigen diabetic retinopathy (HLA-DR) and its influence in proliferative diabetic retinopathy (PDR).
  
  
  METHODS
  We designed a case-control study in which 127 mestizo Mexican patients with DM II and diabetic retinopathy were studied. DNA was extracted and HLA-DR regions were amplified using PCR. Alleles were determined by DNA hybridization. Diagnosis was assessed clinically and by fluorescein angiography. Incidence of HLA-DR alleles in patients was compared with an ethnically matched control group of healthy subjects (n = 98). Statistical significance was established with non-parametric tests.
  
  
  RESULTS
  Patients with diabetic retinopathy showed less frequency of HLA-D11 compared with the control group (p = 0.043). NPDR patients with 10 or more years of DM II showed an increase of HLA-DR7 (p = 0.01).
  
  
  CONCLUSIONS
  Our results suggest that the presence of HLA-DR7 protects against the development of proliferative disease in the diabetic Mexican population.
authors.affiliation: Servicio de Retina, Hospital Luis Sánchez Bulnes, Asociación para Evitar la Ceguera en México (AECM), Calle Vicente García Torres #46, Col. San Lucas Coyoacán, 04030 Mexico City, D.F., Mexico. retinamex@yahoo.com
authors.forename: Hugo
authors.initials: H
authors.lastname: Quiroz-Mercado
authors.forename: Ana
authors.initials: A
authors.lastname: Suárez-Licona
authors.forename: Jans
authors.initials: J
authors.lastname: Fromow-Guerra
authors.forename: Gabriela
authors.initials: G
authors.lastname: López-Carasa
authors.forename: Rubén
authors.initials: R
authors.lastname: Cárdenas-Hernández
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Ruiz-Morales
authors.forename: Cynthia
authors.initials: C
authors.lastname: Portal-Celhay
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000276:immunology; D003930:Diabetic Retinopathy / Q000235:genetics* / Q000276:immunology; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D015809:HLA-DR7 Antigen / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D008297:Male; D008800:Mexico; D008875:Middle Aged
chemical_list: D015809:HLA-DR7 Antigen