title: MRI in lung transplant recipients using hyperpolarized 3He: comparison with CT.
abstract: OBJECTIVE
  To elucidate the ability of 3He-MRI to detect ventilation defects in lung transplant recipients, 3He-MRI was compared to CT for concordance.
  
  
  METHODS
  We examined 14 lung recipients using 3He-MRI on a 1.5 T MR scanner. CT served as a reference method. Up to four representative ventilation defects were defined for each lung on 3He-MRI and compared to corresponding areas on CT.
  
  
  RESULTS
  Altogether, 59 representative ventilation defects were defined on 3He-MRI. Plausible CT correlates were found for 29 ventilation defects; less plausible CT correlates were found for eight defects. In 22 defects (37%) no corresponding CT changes were detected. CT demonstrated correlates for ventilation defects seen on 3He-MRI in only 63% of the cases.
  
  
  CONCLUSIONS
  3He-MRI yields a clear increase in the number of detected ventilation defects compared to CT. This may have an important impact on the early detection of bronchiolitis obliterans in lung transplant recipients.
authors.affiliation: Department of Radiology, University of Mainz Hospital, Mainz, Germany. kgast@radiologie.klinik.uni-mainz.de
authors.forename: Klaus K
authors.initials: KK
authors.lastname: Gast
authors.forename: Magali
authors.initials: M
authors.lastname: Viallon
authors.forename: Balthasar
authors.initials: B
authors.lastname: Eberle
authors.forename: Jana
authors.initials: J
authors.lastname: Lill
authors.forename: Michael U
authors.initials: MU
authors.lastname: Puderbach
authors.forename: Alexander T
authors.initials: AT
authors.lastname: Hanke
authors.forename: Joerg
authors.initials: J
authors.lastname: Schmiedeskamp
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
mesh_terms: D000328:Adult; D005260:Female; D006371:Helium; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D016040:Lung Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012123:Pulmonary Ventilation; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D006371:Helium