title: Chondroitin sulfate-coated polyhydroxyethyl methacrylate membrane prevents adhesion in full-thickness tendon tears of rabbits.
abstract: Polyhydroxyethyl methacrylate (pHEMA) membranes coated on one side with chondroitin sulfate (CS) were used to block adhesion physically and to reduce friction between healing flexor tendons and the surrounding tissue in rabbit forepaws after surgical repair. Digits with pHEMA-only, standard tendon sheath repair, and with no sheath repair were the controls. Over 12 weeks the CS-coated membranes were evaluated for joint flexion, adhesion limitation, and tendon healing progress. The membranes initially allowed for better flexion (ie, for 6 weeks), but their relative superior effectiveness faded afterward. Histology showed that adhesions were less severe and healing was better in the CS-pHEMA membranes at 3 and 6 weeks. If further studies determine precise amounts or thicknesses of CS coats that will maximize its healing properties, CS-pHEMA should prove useful in clinical settings in which restoration of tendon sheath integrity with a minimum of adhesions is not possible.
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, Kirikkale University School of Medicine, Kirikkale, Turkey.
authors.forename: Eftal
authors.initials: E
authors.lastname: Güdemez
authors.forename: Fatih
authors.initials: F
authors.lastname: Ekşioğlu
authors.forename: Petek
authors.initials: P
authors.lastname: Korkusuz
authors.forename: Esin
authors.initials: E
authors.lastname: Aşan
authors.forename: Ihsan
authors.initials: I
authors.lastname: Gürsel
authors.forename: Vasif
authors.initials: V
authors.lastname: Hasirci
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D002809:Chondroitin Sulfates / Q000494:pharmacology*; D004195:Disease Models, Animal; D004338:Drug Combinations; D011102:Polyhydroxyethyl Methacrylate / Q000494:pharmacology*; D011817:Rabbits; D016059:Range of Motion, Articular; D013708:Tendon Injuries / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D001672:Biocompatible Materials; D004338:Drug Combinations; D011102:Polyhydroxyethyl Methacrylate; D002809:Chondroitin Sulfates