title: Invasive adenocarcinoma of the vagina following surgery for adenocarcinoma in situ of the cervix--recurrence or implantation?
abstract: A 51-year-old woman underwent cervical conization for severe glandular abnormal cells. Histology noted adenocarcinoma in situ (AIS) with incomplete excision margins. Four months later, hysterectomy revealed no residual disease. Six months subsequently she developed invasive adenocarcinoma of the upper vagina. This report documents the unusual behavior of AIS and its management difficulties.
authors.affiliation: Department of Obstetrics and Gynaecology, Aberdeen Royal Infirmary, Foresterhill, Scotland. gordonvn@tstt.net.tt
authors.forename: G V
authors.initials: GV
authors.lastname: Narayansingh
authors.forename: G P
authors.initials: GP
authors.lastname: Cumming
authors.forename: S
authors.initials: S
authors.lastname: Dighe
authors.forename: D E
authors.initials: DE
authors.lastname: Parkin
authors.forename: I
authors.initials: I
authors.lastname: Millar
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery; D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery; D019092:Conization; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery; D014625:Vaginal Neoplasms / Q000556:secondary*; D014626:Vaginal Smears