Agranulocytosis associated with lamotrigine in a patient with low-grade glioma.
OBJECTIVE
To report agranulocytosis associated with lamotrigine (LTG) in a patient with a brain tumor.


METHODS
A 59-year-old woman with a low-grade glioma and difficult-to-control partial seizures developed agranulocytosis between 9 and 14 weeks after starting LTG. The patient underwent chemotherapy 2 years previously.


RESULTS
After stopping LTG, the agranulocytosis persisted for 9 days despite 7 days of granulocyte-colony-stimulating factor (G-CSF), and ultimately resolved.


CONCLUSIONS
In this case, the use of LTG was associated with the development of agranulocytosis, and it is likely that this association was causative.
Fadul
Camilo E
CE
Section of Hematology/Oncology, Department of Medicine, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire 03756-0001, USA. camilo.e.fadul@hitchcock.org
Meyer
Louise P
LP
Jobst
Barbara C
BC
Cornell
Cornelius J
CJ
Lewis
Lionel D
LD
D000380:Agranulocytosis / Q000139:chemically induced*; D000927:Anticonvulsants / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000150:complications*; D004828:Epilepsies, Partial / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D005910:Glioma / Q000150:complications*; D006801:Humans; D000077213:Lamotrigine; D008875:Middle Aged; D016896:Treatment Outcome; D014227:Triazines / Q000009:adverse effects*
D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine