title: Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study.
abstract: BACKGROUND
  Rhinovirus infections cause exacerbations of asthma. We postulated that people with asthma are more susceptible to rhinovirus infection than people without the disease and compared the susceptibility of these groups.
  
  
  METHODS
  We recruited 76 cohabiting couples. One person in every couple had atopic asthma and one was healthy. Participants completed daily diary cards of upper-respiratory-tract (URT) and lower-respiratory-tract (LRT) symptoms and measured peak expiratory flow twice daily. Every 2 weeks nasal aspirates were taken and examined for rhinovirus. Mixed models were used to compare risks of infection between groups. We also compared the severity and duration of infections.
  
  
  RESULTS
  We analysed 753 samples. Rhinovirus was detected in 10.1% (38/378) of samples from participants with asthma and 8.5% (32/375) of samples from healthy participants. After adjustment for confounding factors, asthma did not significantly increase risk of infection (odds ratio 1.15, 95% CI 0.71-1.87). Groups did not differ in frequency, severity, or duration of URT infections or symptoms associated with rhinovirus infection. First rhinovirus infection was associated more frequently with LRT infection in participants with asthma than in healthy individuals (12 of 28 infections vs four of 23, respectively, p=0.051). Symptoms of LRT associated with rhinovirus infection were significantly more severe (p=0.001) and longer-lasting in participants with asthma than in healthy participants (p=0.005).
  
  
  CONCLUSIONS
  People with atopic asthma are not at greater risk of rhinovirus infection than healthy individuals but suffer from more frequent LRT infections and have more severe and longer-lasting LRT symptoms.
authors.affiliation: University Medicine, Southampton General Hospital, Southampton, UK. Jonathan.Corne@mail.qmcuh-tr.trent.nhs.uk
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Corne
authors.forename: Clare
authors.initials: C
authors.lastname: Marshall
authors.forename: Sandra
authors.initials: S
authors.lastname: Smith
authors.forename: Jacquie
authors.initials: J
authors.lastname: Schreiber
authors.forename: Gwendolyn
authors.initials: G
authors.lastname: Sanderson
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Holgate
authors.forename: Sebastian L
authors.initials: SL
authors.lastname: Johnston
mesh_terms: D000328:Adult; D001249:Asthma / Q000150:complications*; D015331:Cohort Studies; D003139:Common Cold / Q000145:classification / Q000209:etiology / Q000821:virology*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D012229:Rhinovirus / Q000302:isolation & purification*; D012720:Severity of Illness Index; D013997:Time Factors