Combined effects of steroids, ethanol and protein deficiency on tissue content and urinary and faecal excretion of zinc, copper and iron.
This study was performed in order to determine the relative and combined effects of ethanol, a low protein diet and steroid treatment on bone, muscle, liver, and urinary and faecal excretion of zinc, copper and iron in 64 rats divided into eight groups treated following the Lieber-DeCarli liquid diet technique, with and without dexamethasone, 1 mg/l. Steroids showed a lack of effect on liver zinc, but enhanced ethanol- and low protein-mediated liver iron overload when both factors were combined. Steroids also increased muscle copper, iron and zinc, and bone copper, especially in the low protein, ethanol-fed rats.
González-Reimers
E
E
Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Spain.
Santolaria-Fernández
F
F
Garrido-Benedicto
P
P
Durán-Castellón
M C
MC
Galindo-Martín
L
L
Martínez-Riera
A
A
Viña-Rodríguez
J
J
de la Vega-Prieto
M J
MJ
D000818:Animals; D002492:Central Nervous System Depressants / Q000493:pharmacokinetics; D003300:Copper / Q000378:metabolism / Q000652:urine*; D004338:Drug Combinations; D000431:Ethanol / Q000493:pharmacokinetics*; D005243:Feces / Q000737:chemistry*; D007501:Iron / Q000378:metabolism / Q000652:urine*; D008297:Male; D011488:Protein Deficiency / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013256:Steroids / Q000493:pharmacokinetics*; D014018:Tissue Distribution / Q000502:physiology; D015032:Zinc / Q000378:metabolism / Q000652:urine*
D002492:Central Nervous System Depressants; D004338:Drug Combinations; D013256:Steroids; D000431:Ethanol; D003300:Copper; D007501:Iron; D015032:Zinc