Potential insulinominetic agents of zinc(II) complexes with picolinamide derivatives: preparations of complexes, in vitro and in vivo studies.
Following the finding of in vitro insulinominetic activities of new prepared Zn(II) complexes with amide ligands (2-picolinamide (pa-a) and 6-methyl-2-picolinmethylamide (6mpa-ma)) in isolated rat adipocytes treated with epinephrine in terms of inhibition of free fatty acid release, their blood glucose normalizing effects were observed on daily intraperitoneal injections for 14 d in a type 2 diabetes mellitus model animal, KK-Ay mice. The blood glucose levels of KK-Ay mice were maintained in a normal range during the administration of both complexes. After the administration of each complex for 14 d, the improvement of glucose metabolism was confirmed as judged by the glucose tolerance test.
Ueda
Eriko
E
Department of Chemistry, Graduate School of Science, Osaka City University, Japan.
Yoshikawa
Yutaka
Y
Ishino
Yoshio
Y
Sakurai
Hiromu
H
Kojima
Yoshitane
Y
D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002478:Cells, Cultured; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000032:analysis; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D018716:Molecular Mimicry; D010848:Picolinic Acids / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D015032:Zinc / Q000737:chemistry*
D000577:Amides; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D010848:Picolinic Acids; D015032:Zinc; C003142:picolinamide