title: Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus.
abstract: An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998-1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.
authors.affiliation: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA. okew@cdc.gov
authors.forename: Olen
authors.initials: O
authors.lastname: Kew
authors.forename: Victoria
authors.initials: V
authors.lastname: Morris-Glasgow
authors.forename: Mauricio
authors.initials: M
authors.lastname: Landaverde
authors.forename: Cara
authors.initials: C
authors.lastname: Burns
authors.forename: Jing
authors.initials: J
authors.lastname: Shaw
authors.forename: Zacarías
authors.initials: Z
authors.lastname: Garib
authors.forename: Jean
authors.initials: J
authors.lastname: André
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Blackman
authors.forename: C Jason
authors.initials: CJ
authors.lastname: Freeman
authors.forename: Jaume
authors.initials: J
authors.lastname: Jorba
authors.forename: Roland
authors.initials: R
authors.lastname: Sutter
authors.forename: Gina
authors.initials: G
authors.lastname: Tambini
authors.forename: Linda
authors.initials: L
authors.lastname: Venczel
authors.forename: Cristina
authors.initials: C
authors.lastname: Pedreira
authors.forename: Fernando
authors.initials: F
authors.lastname: Laender
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Yoneyama
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Miyamura
authors.forename: Harrie
authors.initials: H
authors.lastname: van Der Avoort
authors.forename: M Steven
authors.initials: MS
authors.lastname: Oberste
authors.forename: David
authors.initials: D
authors.lastname: Kilpatrick
authors.forename: Stephen
authors.initials: S
authors.lastname: Cochi
authors.forename: Mark
authors.initials: M
authors.lastname: Pallansch
authors.forename: Ciro
authors.initials: C
authors.lastname: de Quadros
mesh_terms: D020121:5' Untranslated Regions; D000293:Adolescent; D000818:Animals; D002213:Capsid / Q000235:genetics; D036022:Capsid Proteins; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D004293:Dominican Republic / Q000453:epidemiology; D005260:Female; D005814:Genes, Viral; D006205:Haiti / Q000453:epidemiology; D006801:Humans; D017589:Immunization Programs; D007223:Infant; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D017354:Point Mutation; D011051:Poliomyelitis / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission / Q000821:virology*; D017955:Poliovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects*; D011159:Population Surveillance; D011995:Recombination, Genetic; D014611:Vaccination; D014774:Virulence
chemical_list: D020121:5' Untranslated Regions; D036022:Capsid Proteins; D011055:Poliovirus Vaccine, Oral; C442540:VP1 protein, Poliovirus