Bioinformatics of large-scale protein interaction networks.
We survey recent techniques for construction and prediction of large-scale protein interaction networks, focusing on computational processing steps. Special emphasis is placed on critical assessment of data completeness and reliability of the various approaches. Once built, protein interaction networks can be used for functional annotation or to generate higher-level biological hypotheses on pathways.
Schächter
Vincent
V
Hybrigenics, Paris, France. vschachter@hybrigenics.fr
D001426:Bacterial Proteins / Q000032:analysis / Q000378:metabolism; D019295:Computational Biology / Q000379:methods*; D020543:Proteome / Q000032:analysis* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000032:analysis* / Q000378:metabolism*
D001426:Bacterial Proteins; D020543:Proteome; D029701:Saccharomyces cerevisiae Proteins