title: Haemangiopericytoma: histological spectrum, immunohistochemical characterization and prognosis.
abstract: Canine haemangiopericytoma (CHP) is a vascular neoplasm thought to be derived from pericytes. The histological pattern and immunohistochemical profile were studied in 31 CHPs. Twenty-three subjects were followed for 2 years to evaluate the correlation among tumour location, histotype, immunostaining and outcome of the disease. Of the 31 CHPs examined, 20 exhibited a perivascular whorled pattern, 8 were storiform and 3 were epithelioid. All tumours were positive for vimentin and negative for cytokeratin, factor VIII-related antigen, glial fibrillary acidic protein and S-100 protein. Seventeen CHPs were positive for actin and nine co-expressed desmin. Six CHPs were also positive for CD34 antigen. The panel of immunohistochemical markers used confirmed the vascular lineage of CHP and aided in the exclusion of other mesenchymal tumours. Of the 23 dogs submitted to follow-up, 6 had recurrence or metastases of the primary tumour. The epithelioid pattern or a noncutaneous location were associated with a poorer prognosis.
authors.affiliation: Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Viale delle Piagge, I-56124 Pisa, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Mazzei
authors.forename: Francesca
authors.initials: F
authors.lastname: Millanta
authors.forename: Simona
authors.initials: S
authors.lastname: Citi
authors.forename: Davide
authors.initials: D
authors.lastname: Lorenzi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Poli
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology*; D004285:Dogs; D005260:Female; D006393:Hemangiopericytoma / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D007558:Italy / Q000453:epidemiology; D008297:Male; D011379:Prognosis; D012042:Registries; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology / Q000662:veterinary*