title: VHS domain -- a longshoreman of vesicle lines.
abstract: The VHS (Vps-27, Hrs and STAM) domain is a 140 residue long domain present in the very NH2-terminus of at least 60 proteins. Based on their functional characteristics and on recent data on the involvement of VHS in cargo recognition in trans-Golgi, VHS domains are considered to have a general membrane targeting/cargo recognition role in vesicular trafficking. Structurally, VHS is a right-handed superhelix of eight helices with charged surface patches probably serving as sites of protein-protein recognition and docking.
authors.affiliation: Department of Pediatrics, University of Tampere, Tampere, Finland.
authors.forename: Olli
authors.initials: O
authors.lastname: Lohi
authors.forename: Anssi
authors.initials: A
authors.lastname: Poussu
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Mao
authors.forename: Florante
authors.initials: F
authors.lastname: Quiocho
authors.forename: Veli Pekka
authors.initials: VP
authors.lastname: Lehto
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D056827:Endosomal Sorting Complexes Required for Transport; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D021601:trans-Golgi Network / Q000378:metabolism
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D010750:Phosphoproteins; D011506:Proteins; C096164:hepatocyte growth factor-regulated tyrosine kinase substrate