[New concepts in the biology of acute myeloid leukemia].
During the last 20 years, several concepts regarding the biology of acute myeloid leukemia (AML) have changed in a profound manner. This has been mainly due to significant advances in the identification, purification and characterization of the primitive hematopoietic cells--including stem and progenitor cells--in which this disorder originates. In the present review article, we discuss some of these new concepts and their relevance in the treatment of AML.
Montesinos
Juan José
JJ
Unidad de Investigación en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, IMSS. Av. Cuauhtémoc 330, Col. Doctores México, D.F. 06720.
Mayani
Héctor
H
D018952:Antigens, CD34 / Q000096:biosynthesis; D006410:Hematopoiesis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology* / Q000473:pathology
D018952:Antigens, CD34