title: A randomized clinical trial of the desensitizing efficacy of three dentifrices.
abstract: The effect on dentinal hypersensitivity from the use of a new dentifrice containing 5.0% potassium nitrate and 0.454% stannous fluoride in a silica base (Colgate Sensitive Maximum Strength Toothpaste, Colgate-Palmolive Co.) over an 8-week period was compared to a commercially available dentifrice containing 5.0% potassium nitrate and 0.243% sodium fluoride in a silica base (positive control [Sensodyne Fresh Mint Toothpaste, Block Drug Company, Inc.]) and to a commercially available nondesensitizing dentifrice containing 0.243% sodium fluoride in a silica base (negative control [Colgate Winterfresh Gel, Colgate-Palmolive Co.]). A total of 120 participants were stratified into 3 balanced groups according to baseline mean air blast (thermal) and tactile (Yeaple Probe) sensitivity scores, gender, and age. Participants brushed their teeth twice daily (morning and evening) for 1 minute. Dentinal hypersensitivity examinations were conducted at baseline, 4 weeks, and 8 weeks by the same dental examiner. After 4- and 8-weeks' use of their assigned products, participants in the new dentifrice group demonstrated statistically significant improvements (p < 0.05) in tactile and air blast sensitivity, as compared to those using the positive and negative control dentifrices.
authors.affiliation: University of the Pacific School of Dentistry, San Francisco, California, USA.
authors.forename: T
authors.initials: T
authors.lastname: Schiff
authors.forename: Y P
authors.initials: YP
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: DeVizio
authors.forename: B
authors.initials: B
authors.lastname: Stewart
authors.forename: P
authors.initials: P
authors.lastname: Chaknis
authors.forename: M E
authors.initials: ME
authors.lastname: Petrone
authors.forename: A R
authors.initials: AR
authors.lastname: Volpe
authors.forename: H M
authors.initials: HM
authors.lastname: Proskin
mesh_terms: D000328:Adult; D000388:Air; D000704:Analysis of Variance; D045424:Complex Mixtures; D003802:Dentifrices / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000175:diagnosis / Q000188:drug therapy*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009566:Nitrates / Q000627:therapeutic use; D010710:Phosphates / Q000627:therapeutic use; D017680:Potassium Compounds / Q000627:therapeutic use; D012822:Silicon Dioxide; D012969:Sodium Fluoride; D014110:Touch
chemical_list: C408633:Colgate Winterfresh Fluoride Gel; D045424:Complex Mixtures; D003802:Dentifrices; D004338:Drug Combinations; D009566:Nitrates; D010710:Phosphates; D017680:Potassium Compounds; C097427:Sensodyne; C444700:colgate sensitive; D012822:Silicon Dioxide; D012969:Sodium Fluoride; D005459:Fluorides