Comparative dermal pharmacology and toxicology of 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) in rodents and primates.
4,4'-Dihydroxybenzophenone-2,4-ditrophenylhydrazone (A-007) has demonstrated anticancer activities, when administered topically to patients with metastatic cancer to the skin. Acute, subacute and subchronic dermal studies with A-007 in adult rabbits, rats, guinea pigs and monkeys failed to demonstrate local or systemic toxicity when applied topically as a 0.25% gel. A-007 did not penetrate the dermal lymphatics and did not produce detectable levels of A-007 in the plasma when applied as a 0.25% gel topically to skin. In the above studies, topically administered A-007 stimulated local sub-epithelial and dermal lymphocyte modulation, with increased CD8+ cytotoxic lymphocytes (CTL) noted, in guinea pig skin. Generally topical A-007 is well tolerated and may have useful immune modulation properties.
Morgan
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LR
DEKK-TEC, Inc. 4200 Canal Street, New Orleans, Louisiana 70119, USA. LRM1579@aol.com
Rodgers
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Hooper
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Ratterree
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Soike
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Serota
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Beis
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Schwartz
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D000042:Absorption; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002522:Chlorocebus aethiops; D005260:Female; D006168:Guinea Pigs; D006835:Hydrazones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D015394:Molecular Structure; D010636:Phenols / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011323:Primates; D011817:Rabbits; D051381:Rats; D012377:Rodentia; D012867:Skin / Q000187:drug effects* / Q000276:immunology
C097674:4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone; D006835:Hydrazones; D010636:Phenols