Domino processes as a tool for recovering substandard reactions. Synthesis and use of nitroacetic acid esters and amides.
[reaction: see text] Elusive nitroacetic acid esters and amides were obtained through a halogen exchange reaction of the corresponding bromoacetic acid derivatives with polymer-supported nitrite anion. The process is flawed by a side product catalyzed degradation of the products. Domino processes turned out to be a powerful tool for overcoming such drawbacks, converting a substandard reaction into an efficient multicomponent preparation of 4-hydroxy-4,5-dihydroisoxazoles.
Scardovi
Noemi
N
Dipartimento di Chimica Organica A. Mangini dell'Università, Viale del Risorgimento, 4-I-40136 Bologna, Italy.
Casalini
Andrea
A
Peri
Francesca
F
Righi
Paolo
P