title: Paradoxical decrease in plasma NOx by L-arginine load in diabetic and non-diabetic subjects.
abstract: L-arginine, a substrate of nitric oxide synthase, was infused (30 g/300 ml/30 min) to patients with or without type 2 diabetes to examine whether or not endothelial dysfunction expressed as attenuated depressor response to the substrate in diabetic patients may accompany attenuated plasma NOx (NO2- and NO3-; an index of NO formation) elevation. Decrease in blood pressure by L-arginine was significantly smaller in diabetic patients than that in non-diabetic patients, and increase in plasma cGMP level in diabetic patients tended to be smaller and retarded than non-diabetic patients. However, plasma NOx decreased in both groups in a similar degree without changes in urinary NOx excretion, implying that NOx in plasma moved to other compartments. These results indicate that plasma NOx could not be solely used as an index of NO formation by L-arginine load and that this paradoxical decrease in plasma NOx would require further examination extending to other NOx compartments.
authors.affiliation: Department of Internal Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Maejima
authors.forename: Mariko
authors.initials: M
authors.lastname: Himeno
authors.forename: Takaharu
authors.initials: T
authors.lastname: Ishibashi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nakano
authors.forename: Matomo
authors.initials: M
authors.lastname: Nishio
authors.forename: Kenzo
authors.initials: K
authors.lastname: Uchida
mesh_terms: D001120:Arginine / Q000008:administration & dosage*; D001786:Blood Glucose; D001794:Blood Pressure / Q000187:drug effects*; D006152:Cyclic GMP / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000097:blood* / Q000652:urine; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000097:blood* / Q000652:urine
chemical_list: D001786:Blood Glucose; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D001120:Arginine; D006152:Cyclic GMP