Array-based proteomics: the latest chip challenge.
Array-based protein technologies are emerging for basic biological research, molecular diagnostics and therapeutic development with the potential of providing parallel functional analysis of hundreds or perhaps hundreds of thousands of proteins simultaneously. Array-based methods are becoming prevalent within proteomics research due to the desire to analyze proteins in an analogous format to that of the DNA microarray. Novel protein biochips are under development in academic laboratories and emerging biotechnology companies to advance the pace and scope of scientific discovery. This review will define array-based proteomics, its current applications and future directions, as well as examine the challenges and limitations of this projected billion dollar industry.
Albala
J S
JS
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA. albala@llnl.gov
D000818:Animals; D000906:Antibodies / Q000737:chemistry; D001331:Automation; D001709:Biotechnology / Q000379:methods / Q000639:trends*; D006801:Humans; D025202:Molecular Diagnostic Techniques; D020411:Oligonucleotide Array Sequence Analysis; D011506:Proteins / Q000032:analysis* / Q000737:chemistry*
D000906:Antibodies; D011506:Proteins