Intravascular lymphomatosis of the lung and liver following eyelid lymphoma in a Chinese man and review of primary pulmonary intravascular lymphomatosis.
Intravascular lymphomatosis (IVL) is characterised by an almost exclusive intravascular proliferation of malignant lymphoid cells, with the diagnosis often made only when the illness is in its terminal phase or at autopsy. We detail a case of IVL affecting the lung and liver of a 49-year-old Chinese man presenting primarily with lung symptoms and incidental findings of abnormal serum transaminase levels, the ante-mortem diagnosis being established on transbronchial lung biopsy and percutaneous liver biopsy specimens, respectively. Histology disclosed CD20 + CD5 - CD10 [corrected] - malignant large mononuclear B cells within the lumina of the blood vessels of the affected organs as well as sinusoids of the liver. Significantly, the patient had a history of large B cell lymphoma affecting the eyelid 18 months prior to the angiotropic disease, suggesting a possible link between the more common types of non-Hodgkin's lymphoma and IVL. A brief review of all cases of primary pulmonary intravascular lymphomatosis is also presented.
Goh
Seng Geok Nicholas
SG
Department of Pathology, Singapore General Hospital.
Chuah
Khoon Leong
KL
Tan
Puay Hoon
PH
D000410:Alanine Transaminase / Q000097:blood; D015703:Antigens, CD / Q000032:analysis; D001219:Aspartate Aminotransferases / Q000097:blood; D001402:B-Lymphocytes / Q000737:chemistry / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005142:Eyelid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy; D019043:Vascular Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase