Retinal change induced in the primate (Macaca mulatta) by oxygen nuclei radiation.
Retinas of primates (Macaca mulatta) were exposed to oxygen nuclei at the Bevatron, Berkeley, California. Color fundus photographs and fluorescein angiograms were taken of the retinas prior to irradiation and up to 5 weeks post exposure. Animals were sacrificed at post exposure intervals for histopathologic examination of the retinas. A series of animals were exposed to 200 kVp X-ray and examined on the same regime as the first series. The results showed a low rad equivalent dose for retinal damage as compared with the X-ray series, i.e., a high quality factor, and a marked compression of the latency between exposure and onset of the retinal pathology.
Bonney
C H
CH
USAF School of Aerospace Medicine, Brooks Air Force Base, Texas, USA.
Beckman
F N
FN
Hunter
D M
DM
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005451:Fluorescein Angiography; D020450:Heavy Ions; D008253:Macaca mulatta; D010100:Oxygen; D010315:Particle Accelerators; D010719:Phosphenes / Q000502:physiology; D011833:Radiation Injuries, Experimental; D012062:Relative Biological Effectiveness; D012160:Retina / Q000503:physiopathology* / Q000528:radiation effects*; D012166:Retinal Hemorrhage / Q000209:etiology / Q000503:physiopathology; D012173:Retinitis / Q000209:etiology / Q000503:physiopathology; D014792:Visual Acuity / Q000528:radiation effects*; D014965:X-Rays
D010100:Oxygen