Fatal diffuse alveolar damage complicating acute myeloid leukemia with abnormal eosinophils and trisomy X.
We describe a case of acute myeloid leukemia (AML) with abnormal eosinophils in a 44-year-old Chinese woman that was complicated by diffuse alveolar damage (DAD) and pulmonary hemorrhage (PH) shortly after induction chemotherapy. Cytogenetic study of bone marrow cells at diagnosis showed a rare aberration of trisomy X (+X) as the sole acquired karyotypic abnormality. We speculate that tissue damage by cellular constituents of the abnormal eosinophils that were released on cell lysis after chemotherapy might be etiologically linked to the occurrence of fatal pulmonary complications.
Wan
T S K
TS
Division of Hematology, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, People's Republic of China.
Yip
S F
SF
Yeung
Y M
YM
Chan
L C
LC
Ma
S K
SK
D000208:Acute Disease; D000328:Adult; D004804:Eosinophils / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006470:Hemorrhage / Q000150:complications; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D008171:Lung Diseases / Q000150:complications; D011650:Pulmonary Alveoli / Q000473:pathology*; D014314:Trisomy / Q000235:genetics*; D014960:X Chromosome / Q000235:genetics*