[The prognostic value of the site and extent of Y chromosome microdeletions on spermatogenesis].
Genes on Y-chromosome are involved in the regulation of spermatogenesis. Y-chromosome microdeletions were identified among infertile patients in a frequency of 7.5-15% on the long arm of the chromosome. These microdeletions were clustered in 3 main regions named AZFa, AZFb, and AZFc. Reanalyzing the histological findings in men with well-defined varying extent of Y-chromosome microdeletions improved our understanding of the prospect of finding testicular spermatozoa. The chances of finding spermatozoa were almost nil in men with microdeletions that include the complete AZFa region or AZFb region or at least two AZF regions. Large microdeletions that include the Yq tip were suggested to cause chromosomal instability and were shown to be prone to Y chromosome loss. In addition, a decrease of sperm count over time in men with AZFc deletions has been reported and the option of spermatozoa cryo-preservation need to be taken in consideration. Analysis of the Y-chromosome microdeletion was found to be of prognostic value in cases of infertility both in terms of clinical management as well as for understanding the etiology of the spermatogenesis impairment.
Kleiman
Sandra E
SE
Institute for the Study of Fertility Lis Maternity Hospital, Clinical Biochemistry Laboratory, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Yogev
Leah
L
Paz
Gedalia
G
Yavetz
Haim
H
D002874:Chromosome Mapping; D006801:Humans; D008297:Male; D011379:Prognosis; D017384:Sequence Deletion; D013091:Spermatogenesis / Q000235:genetics*; D014998:Y Chromosome