The use of snake venom toxins as tools to study platelet receptors for collagen and von Willebrand factor.
A large proportion of the biologically active proteins and peptides present within snake venoms interact with components of the haemostatic system to promote or inhibit the normal sequence of events that lead to clot formation. The venom proteins achieve their effects through interaction with various components of the coagulation cascade, endothelial matrix and platelets. Within the latter group, a number of venom proteins target the interaction of platelets with the major adhesive proteins, von Willebrand factor and collagen. The venom proteins bind either the adhesive protein itself or their receptors on the platelet surface, notably GP-Ib-IX-V and GPVI. This review discusses the substantial contribution that venom proteins have made to our understanding of the role of these two adhesive proteins and their receptors (excluding GPIIb-IIIa) in platelet regulation.
Andrews
R K
RK
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
Kamiguti
A S
AS
Berlanga
O
O
Leduc
M
M
Theakston
R D
RD
Watson
S P
SP
D000818:Animals; D003094:Collagen / Q000378:metabolism / Q000502:physiology; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008958:Models, Molecular; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism* / Q000502:physiology; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000378:metabolism* / Q000502:physiology; D038981:Receptors, Collagen / Q000378:metabolism* / Q000502:physiology; D012910:Snake Venoms / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D014841:von Willebrand Factor / Q000378:metabolism / Q000502:physiology
D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D038981:Receptors, Collagen; D012910:Snake Venoms; D014841:von Willebrand Factor; C028254:von Willebrand factor receptor; D003094:Collagen