Developmental variation in epidermal growth factor receptor size and localization in the malaria mosquito, Anopheles gambiae.
The AGER gene encoding the epidermal growth factor receptor (EGFR) of the malaria mosquito Anopheles gambiae was cloned and sequenced. It represents a canonical member of this family of tyrosine kinase proteins exhibiting many similarities to orthologues from other species, both on the level of genomic organization and protein structure. The mRNA can be detected throughout development. Western analysis with an antibody raised against the extracellular domain of the mosquito protein suggests developmental variation in protein size and location that may be involved in the function of EGFR in the mosquito.
Lycett
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Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Vassilika Vouton, 711 10 Heraklion, Crete, Greece.
Blass
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Louis
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D000818:Animals; D000852:Anopheles / Q000235:genetics*; D001483:Base Sequence; D019556:COS Cells; D002522:Chlorocebus aethiops; D018076:DNA, Complementary; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D017344:Genes, Insect; D019476:Insect Proteins / Q000235:genetics* / Q000378:metabolism; D007303:Insect Vectors / Q000235:genetics*; D007438:Introns; D008288:Malaria; D008969:Molecular Sequence Data; D013347:Subcellular Fractions
D018076:DNA, Complementary; D019476:Insect Proteins; C452619:EGFR protein, Anopheles gambiae; D066246:ErbB Receptors