title: Agranulocytosis associated with lamotrigine in a patient with low-grade glioma.
abstract: OBJECTIVE
  To report agranulocytosis associated with lamotrigine (LTG) in a patient with a brain tumor.
  
  
  METHODS
  A 59-year-old woman with a low-grade glioma and difficult-to-control partial seizures developed agranulocytosis between 9 and 14 weeks after starting LTG. The patient underwent chemotherapy 2 years previously.
  
  
  RESULTS
  After stopping LTG, the agranulocytosis persisted for 9 days despite 7 days of granulocyte-colony-stimulating factor (G-CSF), and ultimately resolved.
  
  
  CONCLUSIONS
  In this case, the use of LTG was associated with the development of agranulocytosis, and it is likely that this association was causative.
authors.affiliation: Section of Hematology/Oncology, Department of Medicine, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire 03756-0001, USA. camilo.e.fadul@hitchcock.org
authors.forename: Camilo E
authors.initials: CE
authors.lastname: Fadul
authors.forename: Louise P
authors.initials: LP
authors.lastname: Meyer
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Jobst
authors.forename: Cornelius J
authors.initials: CJ
authors.lastname: Cornell
authors.forename: Lionel D
authors.initials: LD
authors.lastname: Lewis
mesh_terms: D000380:Agranulocytosis / Q000139:chemically induced*; D000927:Anticonvulsants / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000150:complications*; D004828:Epilepsies, Partial / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D005910:Glioma / Q000150:complications*; D006801:Humans; D000077213:Lamotrigine; D008875:Middle Aged; D016896:Treatment Outcome; D014227:Triazines / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine