Vitreous penetration of levofloxacin in the uninflamed phakic human eye.
OBJECTIVE
To assess the vitreous penetration of oral levofloxacin (a new fluoroquinolone antibiotic with improved Gram positive activity) in uninflamed phakic eyes.


METHODS
15 patients for macula hole surgery were recruited to the study. 10 received a single 500 mg dose of levofloxacin by mouth preoperatively. Five acted as controls. Serum and undiluted vitreous samples were obtained at surgery and analysed by HPLC.


RESULTS
Levofloxacin was detectable 2.5 hours after administration in the vitreous. A peak concentration of 1.6 microg/ml (or mg/l) was measured between 2.5 and 4 hours post-dose.


CONCLUSIONS
Oral levofloxacin reaches the vitreous rapidly in the uninflamed phakic eye. Levels did not reach MIC(90) for the commonest infecting organisms. Nevertheless, levofloxacin would be expected to be active against a higher proportion of infecting organisms than either ciprofloxacin or ofloxacin.
Herbert
E N
EN
St Paul's Eye Unit, 8Z Link, Royal Liverpool University Hospital, Liverpool L7 8XP, UK. enherbert@doctors.org.uk
Pearce
I A
IA
McGalliard
J
J
Wong
D
D
Groenewald
C
C
D000284:Administration, Oral; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D064704:Levofloxacin; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012167:Retinal Perforations / Q000601:surgery; D013607:Tablets; D014821:Vitrectomy / Q000379:methods; D014822:Vitreous Body / Q000378:metabolism*
D000890:Anti-Infective Agents; D013607:Tablets; D064704:Levofloxacin; D015242:Ofloxacin