Aluminium phosphide exposure: implications on rat brain lipid peroxidation and antioxidant defence system.
We investigated the effect of aluminium phosphide exposure (10 mg/kg body weight) on lipid peroxidation and antioxidant defence system in different regions of rat brain. A significant increase in lipid peroxidation in cerebrum, cerebellum and brain stem was observed in aluminium phosphide-exposed rats, which was accompanied by a marked decrease in the activities of antioxidant enzyme, superoxide dismutase and catalase. A decline in the activity of glutathione reductase was also observed, however, no change was seen in the activity of glutathione peroxidase following aluminium phosphide administration. Decreased levels of non-protein thiols and total sulfhydryl groups were also observed after aluminium phosphide treatment. It seems evident that aluminium phosphide exposure significantly enhanced neuronal lipoperoxidative damage with concomitant alterations in the antioxidant defence status thus having serious bearing on the functional and structural status of the central nervous system.
Dua
R
R
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India.
Gill
K D
KD
D000284:Administration, Oral; D017607:Aluminum Compounds / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D001933:Brain Stem / Q000187:drug effects / Q000201:enzymology; D002374:Catalase / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects / Q000201:enzymology; D005980:Glutathione Reductase / Q000378:metabolism; D007928:Lethal Dose 50; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D010575:Pesticides / Q000633:toxicity*; D010720:Phosphines / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013687:Telencephalon / Q000187:drug effects / Q000201:enzymology
D017607:Aluminum Compounds; D000975:Antioxidants; D010575:Pesticides; D010720:Phosphines; C001864:aluminum phosphide; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase