New highly active taxoids from 9 beta-dihydrobaccatin-9,10-acetals.
To synthesize new highly active taxoids, we designed and synthesized 9 beta-dihydro-9,10-acetal taxoids. In vitro study of these analogues clearly showed them to be more potent than docetaxel.
Ishiyama
Takashi
T
Medicinal Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd, Tokyo R&D Center, 16-13 Kita-kasai 1-Chome Edogawa-ku, Tokyo 134-8630, Japan.
Iimura
Shin
S
Ohsuki
Satoru
S
Uoto
Kouichi
K
Terasawa
Hirofumi
H
Soga
Tsunehiko
T
D000080:Acetals / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000077143:Docetaxel; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D043823:Taxoids; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000080:Acetals; D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel