title: Serum thymidine kinase and soluble interleukin-2 receptor predict recurrence of malignant lymphoma.
abstract: Before and after therapy, serum thymidine kinase (TK) and soluble interleukin-2 receptor (sIL-2R) were serially determined in 28 patients with malignant lymphoma (ML). In 15 patients achieving and maintaining complete remission (CR) for more than 2 years, serum TK and sIL-2R were unchanged or decreased gradually. In contrast, logarithmic linear increases of TK and sIL-2R were observed in 13 relapsed patients. The increments of the serum markers occurred more than 10 months before the relapse. A significant positive correlation between the slope of the line for TK and that for sIL-2R was noted. The doubling time for TK estimated from the slope also showed a positive correlation with that for sIL-2R. Taken together, serum TK and sIL-2R were shown to be quite sensitive and interrelated serum markers for the recurrence of ML. Slopes of logarithmic linear increase, which are proper and specific for the individual patients, are inversely correlated with the doubling time and reflect proliferation of ML. We conclude that serum TK and sIL-2R are better predictors of relapse than LDH and the international prognostic index (IPI).
authors.affiliation: First Department of Internal Medicine, Saitama Medical School, Saitama 350-0495, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Wakao
authors.forename: I
authors.initials: I
authors.lastname: Murohashi
authors.forename: K
authors.initials: K
authors.lastname: Tominaga
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Kishimoto
authors.forename: F
authors.initials: F
authors.lastname: Yagasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Itoh
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Sakata
authors.forename: N
authors.initials: N
authors.lastname: Kawai
authors.forename: H
authors.initials: H
authors.lastname: Kayano
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Matsuda
authors.forename: K
authors.initials: K
authors.lastname: Hirashima
authors.forename: M
authors.initials: M
authors.lastname: Bessho
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D005260:Female; D005544:Forecasting; D006801:Humans; D007239:Infections / Q000097:blood; D007700:Kinetics; D008223:Lymphoma / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012995:Solubility; D013937:Thymidine Kinase / Q000097:blood*; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2; D013937:Thymidine Kinase