A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation.
ComK, the master regulator of competence, is degraded by the general stress-related protease ClpCP but must be targeted to this protease by binding to the adapter protein MecA. The genome of Bacillus subtilis contains a paralog of mecA, ypbH. We show in the present study that YpbH, like MecA, binds ClpC and that its elimination or overproduction affects competence and sporulation.
Persuh
Marjan
M
Public Health Research Institute, New York, New York 10016, USA.
Mandic-Mulec
Ines
I
Dubnau
David
D
D001412:Bacillus subtilis / Q000235:genetics / Q000502:physiology*; D001426:Bacterial Proteins / Q000378:metabolism* / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D013171:Spores, Bacterial / Q000502:physiology; D014158:Transcription, Genetic
D001426:Bacterial Proteins; C087481:ClpC protein, Bacteria; D006360:Heat-Shock Proteins; C083616:mecA protein, Bacillus subtilis