Allergic contact dermatitis to latanoprost.
An 85-year-old male with glaucoma presented with a 1-1/2 year history of tearing; red eyes; and pruritic, edematous, eczematous eyelids. Treatment for presumed ocular rosacea and seborrhea was unhelpful. Patch testing to our standard 64 antigens yielded a positive reaction to Balsam of Peru. Notably, benzalkonium chloride, thimerosal, and other preservatives elicited negative reactions. Repeat open application testing elicited positive results to Xalatan (latanoprost) 0.005% ophthalmic solution (Pharmacia & Upjohn, Kalamazoo, MI). A second session of patch tests to 10 personal products, in addition to Xalatan 0.005% solution and the Xalatan vehicle (provided by the manufacturer), elicited a strong positive reaction only to the full preparation of Xalatan 0.005% solution. This report describes the first known case of ACD to latanoprost, a new prostaglandin analog that is widely prescribed for treatment of glaucoma.
Jerstad
Kelly Michele
KM
Department of Dermatology, University of Minnesota and the Minneapolis VA, Minneapolis, MN, USA.
Warshaw
Erin
E
D000368:Aged; D000369:Aged, 80 and over; D003233:Conjunctivitis, Allergic / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D003937:Diagnosis, Differential; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D000077338:Latanoprost; D008297:Male; D009883:Ophthalmic Solutions / Q000009:adverse effects*; D010328:Patch Tests; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects*
D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost