title: Association between acetaminophen or nonsteroidal antiinflammatory drugs and risk of developing ovarian, breast, or colon cancer.
abstract: OBJECTIVE
  To explore the association between exposure to acetaminophen (paracetamol) or nonsteroidal antiinflammatory drugs (NSAIDs) and risk of developing ovarian, breast, or colon cancer.
  
  
  METHODS
  Retrospective case-control study
  
  
  METHODS
  General practice offices.
  
  
  METHODS
  Four hundred eighty-three women with ovarian cancer and 1877 women matched for age, years of medical history in computer record, general practice attended, and calendar time; 3706 women with breast cancer and 14,155 matched control subjects; and 635 women with colon cancer and 2434 matched control subjects.
  
  
  METHODS
  United Kingdom-based General Practice Research Database was searched for women aged 50-89 years with a first-time diagnosis of ovarian, breast, or colon cancer and for matched controls to assess prescription analgesic exposure.
  
  
  RESULTS
  Regular acetaminophen exposure (> or = 30 prescriptions) was associated with a slightly decreased risk of developing breast (odds ratio [OR] 0.8, 95% confidence interval [CI] 0.7-1.0) but not ovarian (OR 1.0, 95% CI 0.6-1.5) or colon (OR 1.0, 95% Cl 0.7-1.4) cancer. Regular NSAID exposure was associated with a reduced risk of colon (OR 0.5, 95% CI 0.3-0.9) but not ovarian or breast cancer.
  
  
  CONCLUSIONS
  We found no evidence for a decreased ovarian cancer risk for women with regular acetaminophen or NSAID exposure.
authors.affiliation: Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Switzerland. Christoph.Meier@unibas.ch
authors.forename: Christoph R
authors.initials: CR
authors.lastname: Meier
authors.forename: Stephen
authors.initials: S
authors.lastname: Schmitz
authors.forename: Hershel
authors.initials: H
authors.lastname: Jick
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D008875:Middle Aged; D004366:Nonprescription Drugs / Q000627:therapeutic use; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D012189:Retrospective Studies; D018570:Risk Assessment; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004366:Nonprescription Drugs; D000082:Acetaminophen