title: Oligomeric acylphloroglucinols from myrtle (Myrtus communis).
abstract: The dimeric nonprenylated acylphloroglucinol semimyrtucommulone (6) was obtained from the leaves of myrtle (Myrtus communis) as a 2:1 mixture of two rotamers. The known trimeric phloroglucinol myrtucommulone A (1) was also isolated and characterized spectroscopically as a silylated cyclized derivative (5). Myrtucommulone A showed significant antibacterial activity against multidrug-resistant (MDR) clinically relevant bacteria, while semimyrtucommulone was less active.
authors.affiliation: DISCAFF, Università del Piemonte Orientale, Viale Ferrucci 33, 28100 Novara, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Appendino
authors.forename: Federica
authors.initials: F
authors.lastname: Bianchi
authors.forename: Alberto
authors.initials: A
authors.lastname: Minassi
authors.forename: Olov
authors.initials: O
authors.lastname: Sterner
authors.forename: Mauro
authors.initials: M
authors.lastname: Ballero
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004352:Drug Resistance, Microbial; D007558:Italy; D013058:Mass Spectrometry; D015394:Molecular Structure; D027822:Myrtaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; C455139:myrtucommulone A; C455138:semimyrtucommulone; D010696:Phloroglucinol