A randomized clinical trial of the desensitizing efficacy of three dentifrices.
The effect on dentinal hypersensitivity from the use of a new dentifrice containing 5.0% potassium nitrate and 0.454% stannous fluoride in a silica base (Colgate Sensitive Maximum Strength Toothpaste, Colgate-Palmolive Co.) over an 8-week period was compared to a commercially available dentifrice containing 5.0% potassium nitrate and 0.243% sodium fluoride in a silica base (positive control [Sensodyne Fresh Mint Toothpaste, Block Drug Company, Inc.]) and to a commercially available nondesensitizing dentifrice containing 0.243% sodium fluoride in a silica base (negative control [Colgate Winterfresh Gel, Colgate-Palmolive Co.]). A total of 120 participants were stratified into 3 balanced groups according to baseline mean air blast (thermal) and tactile (Yeaple Probe) sensitivity scores, gender, and age. Participants brushed their teeth twice daily (morning and evening) for 1 minute. Dentinal hypersensitivity examinations were conducted at baseline, 4 weeks, and 8 weeks by the same dental examiner. After 4- and 8-weeks' use of their assigned products, participants in the new dentifrice group demonstrated statistically significant improvements (p < 0.05) in tactile and air blast sensitivity, as compared to those using the positive and negative control dentifrices.
Schiff
T
T
University of the Pacific School of Dentistry, San Francisco, California, USA.
Zhang
Y P
YP
DeVizio
W
W
Stewart
B
B
Chaknis
P
P
Petrone
M E
ME
Volpe
A R
AR
Proskin
H M
HM
D000328:Adult; D000388:Air; D000704:Analysis of Variance; D045424:Complex Mixtures; D003802:Dentifrices / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000175:diagnosis / Q000188:drug therapy*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009566:Nitrates / Q000627:therapeutic use; D010710:Phosphates / Q000627:therapeutic use; D017680:Potassium Compounds / Q000627:therapeutic use; D012822:Silicon Dioxide; D012969:Sodium Fluoride; D014110:Touch
C408633:Colgate Winterfresh Fluoride Gel; D045424:Complex Mixtures; D003802:Dentifrices; D004338:Drug Combinations; D009566:Nitrates; D010710:Phosphates; D017680:Potassium Compounds; C097427:Sensodyne; C444700:colgate sensitive; D012822:Silicon Dioxide; D012969:Sodium Fluoride; D005459:Fluorides