The natural resistance-associated macrophage protein 1 Slc11a1 (formerly Nramp1) and iron metabolism in macrophages.
Slc11a1 (solute carrier family 11 member 1) (formerly Nramp1) modulation of iron metabolism in macrophages plays an important role in early phase macrophage activation, and therefore host innate immunity. This review focuses on the role of Nramp1 in intramacrophage iron metabolism, with emphasis on the two prevailing mechanisms of Nramp1 modulation of iron metabolism in macrophages.
Wyllie
Samuel
S
Michael E. DeBakey Department of Surgery, The Methodist Hospital/Baylor College of Medicine Liver Center, Baylor College of Medicine, Houston, TX 77030, USA.
Seu
Philip
P
Goss
John A
JA
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000378:metabolism*; D001483:Base Sequence; D027682:Cation Transport Proteins / Q000378:metabolism*; D016207:Cytokines / Q000502:physiology; D007113:Immunity, Innate; D007501:Iron / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D000099173:Natural Resistance-associated Macrophage Protein 1
D027682:Cation Transport Proteins; D016207:Cytokines; D007501:Iron; D000099173:Natural Resistance-associated Macrophage Protein 1