Polyunsaturated fatty acids (PUFA) regulate neurotransmitter contents in rat brain.
The effects of feeding of 6-propylthiouracil (6-PTU) and polyunsaturated fatty acids (PUFA) independently and in combination and administration (ip) of a single dose of triiodothyronine (T3) (2.5 microg/100 g body wt) along with feeding of 6-PTU and PUFA were studied in rat brain. Dopamine (DA), 5-hydroxytryptophan (5-HTP), serotonin (5-HT), 5-hydroxy indole acetic acid (5-HIAA), norepinephrine (NE) and epinephrine (EPI) contents were assayed in the hypothalamus and cerebral cortex regions. It was found that 6-PTU feeding resulted in decrease in dopamine, 5-HT, 5-HTP and 5-HIAA in both regions. In animals fed with PUFA followed by administration of T3, the DA level was found normal.
Varghese
S
S
Department of Zoology, University of Kerala, Kariavattom, Thiruvanantpuram, India.
Shameena
B
B
Lakshmy
P S
PS
Biju
M P
MP
Easwar Shankar
P N
PN
Paulose
C S
CS
Oommen
O V
OV
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004032:Diet; D004338:Drug Combinations; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006728:Hormones / Q000378:metabolism; D008297:Male; D011441:Propylthiouracil / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D015306:Biogenic Monoamines; D004338:Drug Combinations; D005231:Fatty Acids, Unsaturated; D006728:Hormones; D011441:Propylthiouracil