Somatosensory perception in a remote pain-free area and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from long-term trapezius myalgia.
In patients with localized musculoskeletal pain, spread of pain and tenderness outside the primarily painful area and sometimes even generalization of pain have been reported, the latter possibly indicating a dysfunction of endogenous pain modulatory systems. The purpose of the study was to use patients with long-term trapezius myalgia as a model to investigate the possible influence of a localized muscle pain on somatosensory processing in a remote pain-free area and the effect of heterotopic noxious conditioning stimulation (HNCS) on 'diffuse noxious inhibitory controls' (DNIC) related mechanisms. Altered somatosensory processing may indicate subclinical derangement of endogenous modulatory systems. Ten patients with long-term (> or = 1 year) trapezius myalgia and 10 age- and sex-matched healthy controls participated. Pressure pain sensitivity, low threshold mechanoreceptive function and thermal sensitivity, including thermal pain, were assessed at the right thigh before, during and following HNCS. Pain was induced in the forearm by the tourniquet test. At rest allodynia to pressure was found at the thigh in conjunction with hypoaesthesia to cold (p<0.03 and p<0.01 respectively), in patients compared with controls. During HNCS, the sensitivity to pressure pain and suprathreshold heat pain decreased in patients and controls alike (p<0.02 and p<0.04 respectively) and returned to baseline following HNCS. In conclusion, in a remote non-painful area allodynia to pressure and hypoaesthesia to cold were found in conjunction with preserved function of DNIC-related mechanisms. Whether altered central somatosensory processing at rest may indicate a predisposition for further spread of pain is at present unclear.
Leffler
Ann-Sofie
AS
Department of Surgical Sciences, Section of Clinical Pain Research, Karolinska Hospital/Institutet, S-171 76 Stockholm, Sweden. Ann-Sofie.Leffer@kirurgi.ki.se
Hansson
Per
P
Kosek
Eva
E
D001794:Blood Pressure; D002908:Chronic Disease; D003080:Cold Temperature; D006339:Heart Rate; D006358:Hot Temperature; D006801:Humans; D008465:Mechanoreceptors / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009433:Neural Inhibition; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement; D017288:Pain Threshold; D020671:Posterior Horn Cells / Q000503:physiopathology*; D011312:Pressure; D012677:Sensation; D012782:Shoulder; D013848:Thigh / Q000503:physiopathology*; D014111:Tourniquets