Malonyl CoA control of fatty acid oxidation in the diabetic rat heart.
Increased fatty acid metabolism can decrease cardiac function and efficiency, and may therefore contribute to the outcome of ischemic injury in the diabetic. Alterations in the control of myocardial malonyl CoA levels is an important contributing factor to these high fatty acid oxidation rates. This includes alterations in AMPK, ACC, and MCD activity in the diabetic rat heart. A further understanding of how malonyl CoA controls fatty acid oxidation in the diabetic heart should help identify new targets for pharmacological intervention which decreases the reliance of the heart on fatty acid oxidation, and ultimately improves heart function.
Lopaschuk
G D
GD
Cardiovascular Research Group, University of Alberta, Edmonton, Canada.
D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D008316:Malonyl Coenzyme A / Q000378:metabolism*; D008954:Models, Biological; D017202:Myocardial Ischemia / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D051381:Rats
D005230:Fatty Acids, Nonesterified; D011768:Pyruvate Dehydrogenase Complex; D008316:Malonyl Coenzyme A; D000103:Acetyl-CoA Carboxylase