title: The influence of preoperative antibiotics on success of endosseous implants at 36 months.
abstract: The benefits of prophylactic antibiotics are well recognized in dentistry. However, their routine use in the placement of endosseous dental implants remains controversial. As part of the comprehensive Dental Implant Clinical Research Group (DICRG) clinical implant study, the preoperative or postoperative use of antibiotics, the type used, and the duration of coverage were left to the discretion of the surgeon. These data for 2,973 implants were recorded and correlated with failure of osseointegration during healing (Stage 1), at surgical uncovering (Stage 2), before loading the prosthesis (Stage 3), and from prosthesis loading to 36 months (Stage 4). The results showed a significantly higher survival rate at each stage of treatment in patients who had received preoperative antibiotics.
authors.affiliation: Department of Oral & Maxillofacial Surgery, Virginia Commonwealth University School of Dentistry, Richmond, VA, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Laskin
authors.forename: C D
authors.initials: CD
authors.lastname: Dent
authors.forename: H F
authors.initials: HF
authors.lastname: Morris
authors.forename: S
authors.initials: S
authors.lastname: Ochi
authors.forename: J W
authors.initials: JW
authors.lastname: Olson
mesh_terms: D000497:Alloys; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D002710:Chlorhexidine / Q000627:therapeutic use; D016000:Cluster Analysis; D020099:Coated Materials, Biocompatible; D000044:Dental Abutments; D003722:Dental Alloys; D015921:Dental Implants; D017267:Dental Prosthesis Design; D019094:Dental Prosthesis, Implant-Supported; D019232:Dental Restoration Failure; D017886:Durapatite; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D009067:Mouthwashes / Q000627:therapeutic use; D016348:Osseointegration; D013223:Statistics as Topic; D013499:Surface Properties; D016019:Survival Analysis; D013997:Time Factors; D014025:Titanium; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D000497:Alloys; D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D020099:Coated Materials, Biocompatible; D003722:Dental Alloys; D015921:Dental Implants; D009067:Mouthwashes; C031462:titanium alloy (TiAl6V4); D017886:Durapatite; D014025:Titanium; D002710:Chlorhexidine