[Effect of opioid peptides on the repair regeneration of the bone tissue].
The study is made of the effects of selective agonists of opioid receptors (DAGO--the agonist of mu-receptors, DSLET--the agonist of delta-receptors, dynorphin A,I-13,--the agonist of kappa-receptors) on reparative osteogenesis in CBA mice. The drugs were injected intraperitoneally within 7 days after bone fracture in equimolar doses: DAGO--6.3 mcg/kg, DSLET--10 mcg/kg, dynorphin A (1-13)--20.2 mcg/kg. It was established that the use of DSLET and DAGO accelerates the development of newly-synthesized spongy bone tissue in the bone regenerate. This manifested with its early appearance (4 days after the fracture) as well as higher indices of specific volumes of bone tissue in the regenerate within the experiment (7, 10, 14 days after bone fracture) in comparison with the control animal group. Dynorphin A(1-13) had no influence on regenerate formation in our experiments.
Liashev
Iu D
IuD
Kursk State Medical University, 305041, Kursk.
D000818:Animals; D002146:Bony Callus / Q000187:drug effects* / Q000473:pathology; D004399:Dynorphins / Q000494:pharmacology; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000494:pharmacology; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D017102:Fracture Healing / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D018847:Opioid Peptides / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology; D013978:Tibial Fractures / Q000473:pathology
D018847:Opioid Peptides; D010446:Peptide Fragments; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine; C026843:dynorphin (1-13); D004399:Dynorphins; C034318:enkephalin, Ser(2), Leu(5), Thr(6)-