TEM derivative-producing Enterobacter aerogenes strains: dissemination of a prevalent clone.
TEM-24 (CAZ-6) extended-spectrum beta-lactamase (ESBL) was detected in 1988 in Clermont-Ferrand, France, in Klebsiella pneumoniae (bla(TEM-24)) and Enterobacter aerogenes (bla(TEM-24b)), and since 1994, a TEM-24-producing E. aerogenes clonal strain has been observed elsewhere in the country. To determine if the spread of this clonal strain was restricted to TEM-24-producing E. aerogenes strains, 84 E. aerogenes strains (non-TEM/SHV-producing strains, TEM-1- or -2-producing strains, and different ESBL-producing strains), isolated from 1988 to 1999 in Clermont-Ferrand (n = 59) and in 11 other French hospitals in 1998 (n = 25), were studied. A clonal strain was found for TEM-24- but also for TEM-3- and TEM-1- or 2-producing isolates. This study shows that there is a clonal strain dependent on acquisition of the TEM-type enzyme (TEM-24 and other TEM types).
Dumarche
P
P
Faculté de Médecine, Laboratoire de Bactériologie, 63001 Clermont-Ferrand Cedex, France.
De Champs
C
C
Sirot
D
D
Chanal
C
C
Bonnet
R
R
Sirot
J
J
D001426:Bacterial Proteins; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000235:genetics; D004754:Enterobacter / Q000201:enzymology* / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D005602:France / Q000453:epidemiology; D006801:Humans; D017720:Molecular Epidemiology; D010957:Plasmids / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012270:Ribosomes / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
D001426:Bacterial Proteins; D004269:DNA, Bacterial; C121000:TEM24 beta-lactamase; D001618:beta-Lactamases