Botanical antioxidants for chemoprevention of photocarcinogenesis.
The incidence of non-melanoma skin cancer, consisting of basal- and squamous- cell carcinoma, continues to increase in the United States and elsewhere. Solar ultraviolet (UV) B radiation has been implicated as its main cause. This adverse effect of UVB has become a major human health concern. Therefore, development of novel strategies to reduce the occurrence of skin cancer is a highly desirable goal. Because UV radiation is known to cause excessive generation of reactive oxygen species (ROS) thereby resulting in an oxidative stress condition, the approaches aimed at counteracting ROS production may be useful for the prevention of skin cancer. One approach to reduce its occurrence is through 'Photochemoprotection', which we define as 'the use of agents capable of ameliorating the adverse effects of UVB on the skin'. Among many photochemoprotective agents, botanical antioxidants are showing promise. We propose that the use of botanical antioxidants, in combination with the use of sunscreens and educational efforts to avoid excessive sun exposure, may be an effective strategy for reduction of incidence of skin cancer and other UV-mediated damage in humans.
Afaq
Farrukh
F
Department of Dermatology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA.
Adhami
Vaqar M
VM
Ahmad
Nihal
N
Mukhtar
Hasan
H
D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D047310:Apigenin; D003474:Curcumin / Q000627:therapeutic use; D005419:Flavonoids / Q000627:therapeutic use; D006801:Humans; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D000077185:Resveratrol; D012838:Silymarin / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000209:etiology / Q000517:prevention & control*; D013267:Stilbenes / Q000627:therapeutic use; D013662:Tea; D014466:Ultraviolet Rays / Q000009:adverse effects*
D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D005419:Flavonoids; D011837:Radiation-Protective Agents; D012838:Silymarin; D013267:Stilbenes; D013662:Tea; D047310:Apigenin; D003474:Curcumin; D000077185:Resveratrol