Comparison of chronic exposures received by radiation workers using different biological end-points with the doses recorded by TLD.
The frequency of different biological end-points such as translocation, dicentrics (DC) and micronuclei (MN) was studied in 14 radiation workers and 21 non-radiation workers. The average frequencies for different types of aberrations were significantly higher in radiation workers compared to those of respective aberrations in non-radiation workers. Out of 14 radiation workers, eight subjects showed a dose above the detection limit as per translocation and seven subjects as per DC frequency and no patient showed a dose above the detection limit as per MN frequency. Regression analysis carried out between the recorded doses according to Thermo Luminescence Dosimeter (TLD) and the dose estimated as per translocation frequency gave a correlation coefficient of 0.32, whereas that obtained with TLD dose and the dose estimated as per DC was 0.81. When the correlation was made between the TLD dose, which was above 0.15 Gy (the detection limit for translocation), and the dose estimated as per translocation frequency in these subjects, a correlation coefficient of 0.98 was found. A similar analysis between the TLD dose above 0.5 Gy (the detection limit for DC) and the dose estimated as per DC frequency in these subjects, a correlation coefficient of 0.26 resulted. This paper discusses the reasons for the poor correlation obtained between TLD dose and dose estimated as per DC and MN frequency.
Venkatachalam
P
P
Health and Safety Division, SHINE Group, Indira Gandhi Centre for Atomic Research, Kalpakkam, Tamil Nadu, India.
Paul
S F
SF
Prabhu
B K
BK
Mohankumar
M N
MN
Jeevanram
R K
RK
D000328:Adult; D002869:Chromosome Aberrations; D023381:Endpoint Determination; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000097:blood / Q000528:radiation effects*; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects*; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis*; D011829:Radiation Dosage; D012044:Regression Analysis; D013819:Thermoluminescent Dosimetry; D014178:Translocation, Genetic