title: Tumor necrosis factor-alpha, sphingomyelinase and ceramides activate tyrosine kinase, p21Ras and phosphatidylinositol 3-kinase: implications for glucose transport and insulin resistance.
authors.affiliation: Department of Biochemistry, University of Alberta, Edmonton, Canada.
authors.forename: A N
authors.initials: AN
authors.lastname: Hanna
authors.forename: J
authors.initials: J
authors.lastname: Xu
authors.forename: D N
authors.initials: DN
authors.lastname: Brindley
mesh_terms: D000818:Animals; D001692:Biological Transport; D002518:Ceramides / Q000494:pharmacology*; D004789:Enzyme Activation; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D007700:Kinetics; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism; D051381:Rats; D013108:Sphingomyelin Phosphodiesterase / Q000494:pharmacology*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
chemical_list: D002518:Ceramides; C064769:N-acetylsphingosine; D014409:Tumor Necrosis Factor-alpha; D019869:Phosphatidylinositol 3-Kinases; D011505:Protein-Tyrosine Kinases; D013108:Sphingomyelin Phosphodiesterase; D016283:Proto-Oncogene Proteins p21(ras); D005947:Glucose; D013110:Sphingosine