title: [The concept of abruption of pancreatic necrosis--key to the solution of the problem of destructive pancreatitis].
abstract: The main criterion of severity of acute destructive pancreatitis (ADP) is the volume of pancreatonecrosis formed during the first 24 hours of the disease. A prognostic system is developed allowing to urgently detect the "risk group"--patients with the developing massive pancreatonecrosis by means of the assessment of clinical criteria. In the process of intensive therapy of the "risk group" patients there occurs arresting, "abruption" of the destructive process which greatly improves the results of treatment (the frequency of purulent complications decreases from 32% to 14%, lethality from 45% to 19%). Different methods of "abrupting" therapy are described, the best of them is a combination of curative plasmapheresis with the intraaortal perfusion of the splanchnic area with antienzymes, antihypoxants and antithrombotics. In the group of 17 patients with severe ADP treated by the method described suppuration was noted in 1 (6%) patient, and no lethal outcomes. The pressing problem is to increase the number of patients with severe ODP treated by the method of "abrupting" therapy as early as possible which can be achieved with the help of early hospitalization, with using prognostic systems and creation of a network of specialized pancreatological clinics with the corresponding equipment.
authors.forename: A D
authors.initials: AD
authors.lastname: Tolstoĭ
authors.forename: V B
authors.initials: VB
authors.lastname: Krasnorogov
authors.forename: V R
authors.initials: VR
authors.lastname: Gol'tsov
authors.forename: V G
authors.initials: VG
authors.lastname: Dvoĭnov
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D011379:Prognosis; D012720:Severity of Illness Index; D016896:Treatment Outcome