In vitro bactericidal activity of ABT-773 and amoxicillin against erythromycin-susceptible and -resistant strains of Streptococcus pyogenes.
The bactericidal activity of ABT-773 was compared with amoxicillin against 10 clinical isolates of S. pyogenes (six erythromycin susceptible and four erythromycin resistant). The MIC ranges (mg/L) were 0.004-0.25 of ABT-773 and 0.015-0.12 of amoxicillin. At 24 h, ABT-773 concentrations of 2 x MIC and 8 x MIC were bactericidal against three and six organisms, respectively. In comparison, amoxicillin was bactericidal against all 10 organisms at both test concentrations.
Pendland
Susan L
SL
The University of Illinois at Chicago, College of Pharmacy, Department of Pharmacy Practice, Microbiology Research Laboratory, 833 South Wood Street, Chicago, IL 60612, USA. pendland@uic.edu
Neuhauser
Melinda M
MM
Prause
Jennifer L
JL
D000658:Amoxicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D048628:Ketolides; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D013297:Streptococcus pyogenes / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D048628:Ketolides; D010406:Penicillins; D004917:Erythromycin; D000658:Amoxicillin; C405499:cethromycin