title: The linkage information content value of polymorphism genetic markers in model-free linkage analysis.
abstract: Guo and Elston [Hum Hered 1999;49:112-118] developed a linkage information content (LIC) value to measure the informativeness of a marker for identity-by-descent (IBD) sharing status of relative pairs. LIC values were derived for five types of relative pairs: full sib, half sib, grandparent-grandchild, first cousin and avuncular. In this paper, we give corrected LIC values for full sib, grandparent-grandchild, first cousin and avuncular pairs, and indicate the availability of a computer program to calculate them.
authors.affiliation: Division of Medical Genetics, Department of Medicine and Pediatrics, Spielberg Pediatrics Research Center, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif. 90048, USA. Xiuqing.Guo@cshs.org
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Guo
authors.forename: Jane M
authors.initials: JM
authors.lastname: Olson
authors.forename: Robert C
authors.initials: RC
authors.lastname: Elston
authors.forename: Tianhua
authors.initials: T
authors.lastname: Niu
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D003627:Data Interpretation, Statistical; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers