Oral delivery of antigens in liposomes with some lipid compositions modulates oral tolerance to the antigens.
Several liposomes containing ovalbumin (OVA), a model antigen, with different lipid compositions were prepared in order to evaluate their ability to induce oral tolerance. Oral administration of these liposomal OVAs induced suppression of the proliferative responses of popliteal lymph node cells from the treated mice to OVA, suggesting that these treated mice were tolerized. The efficiency of the induction of oral tolerance was affected by the liposome composition. OVA entrapment in these liposomes could modulate the tolerizing dose of OVA itself. These results suggest that some liposomes can be suitable antigen-delivery systems for modulated and/or effective induction of oral tolerance.
Masuda
Kazuyoshi
K
Shionogi Research Laboratories, Shionogi & Co, Ltd, Osaka, Japan. kazuyoshi.masuda@shionogi.co.jp
Horie
Kazutoshi
K
Suzuki
Ryuji
R
Yoshikawa
Takayoshi
T
Hirano
Koichiro
K
D000284:Administration, Oral; D000818:Animals; D000941:Antigens / Q000008:administration & dosage* / Q000276:immunology; D004337:Drug Carriers; D007108:Immune Tolerance; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology
D000941:Antigens; D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D010047:Ovalbumin