Immune evasion in human papillomavirus-associated cervical cancer.
Tumour-associated viruses produce antigens that, on the face of it, are ideal targets for immunotherapy. Unfortunately, these viruses are experts at avoiding or subverting the host immune response. Cervical-cancer-associated human papillomavirus (HPV) has a battery of immune-evasion mechanisms at its disposal that could confound attempts at HPV-directed immunotherapy. Other virally associated human cancers might prove similarly refractive to immuno-intervention unless we learn how to circumvent their strategies for immune evasion.
Tindle
Robert W
RW
Sir Albert Sakzewski Virus Research Centre, Royal Children's Hospital, Herston, Australia. r.tindle@mailbox.uq.edu.au
D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D002213:Capsid / Q000276:immunology; D002472:Cell Transformation, Viral; D003062:Codon / Q000235:genetics; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D015967:Gene Expression Regulation, Viral; D005815:Genetic Code; D006801:Humans; D007108:Immune Tolerance; D007157:Immunologic Surveillance; D007372:Interferons / Q000502:physiology; D015603:Keratinocytes / Q000821:virology; D051379:Mice; D008822:Mice, Transgenic; D018716:Molecular Mimicry; D009856:Oncogene Proteins, Viral / Q000276:immunology / Q000502:physiology; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology*; D030361:Papillomavirus Infections / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology / Q000502:physiology
D000956:Antigens, Viral; D003062:Codon; D009856:Oncogene Proteins, Viral; D014764:Viral Proteins; D007372:Interferons