title: Synthesis of 188 Re-labelled long chain alkyl diaminedithiol for therapy of liver cancer.
abstract: Radioisotope-labelled lipiodol has been used in the therapy of liver cancer. Recently a lipiodol solution of 188Re-labelled diaminedithiol (DD) has been reported to show a high uptake in the liver cancer. We synthesized long-chain alkyl DD derivatives to improve their uptake and retention in tissue. As the length of the alkyl chain increased, tissue uptake and retention also increased due to hydrophobic interaction with lipiodol. Among the synthesized compounds, the lipiodol solution of 188Re-HDD, the DD derivative with the longest side chain (C16), is a promising agent for therapy of liver cancer.
authors.affiliation: Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Y-S
authors.initials: YS
authors.lastname: Lee
authors.forename: J M
authors.initials: JM
authors.lastname: Jeong
authors.forename: Y J
authors.initials: YJ
authors.lastname: Kim
authors.forename: J W
authors.initials: JW
authors.lastname: Chung
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: Y-G
authors.initials: YG
authors.lastname: Suh
authors.forename: D S
authors.initials: DS
authors.lastname: Lee
authors.forename: J-K
authors.initials: JK
authors.lastname: Chung
authors.forename: M C
authors.initials: MC
authors.lastname: Lee
mesh_terms: D000818:Animals; D006801:Humans; D007459:Iodized Oil / Q000493:pharmacokinetics*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000532:radiotherapy; D008168:Lung / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D014018:Tissue Distribution
chemical_list: D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C464431:rhenium diaminedithiol; D007459:Iodized Oil