A retrospective study of 19 cases of canine myelofibrosis.
Nineteen cases of myelofibrosis were identified among 456 canine bone marrow specimens submitted for analysis. Myelofibrosis was classified as primary in I dog and as secondary in 18 dogs. Clinical conditions associated with secondary myelofibrosis included immune-mediated hemolytic anemia (n = 5), neoplasia (n = 4), and long-term drug treatment (n = 4). Drugs administered included phenobarbital, phenytoin, phenylbutazone, and colchicine. Bone marrow necrosis was observed in 5 dogs. Eight dogs were treated with immunosuppressive doses of prednisolone, and 3 were treated with erythropoietin. Half of the dogs with secondary myelofibrosis recovered from their cytopenias and were alive from 4 months to 5 years after diagnosis.
Weiss
Douglas J
DJ
Department of Veterinary PathoBiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA. weiss005@tc.umn.edu
Smith
Stephanie A
SA
D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000662:veterinary; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D004283:Dog Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology*; D004285:Dogs; D005260:Female; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D009336:Necrosis; D009369:Neoplasms / Q000150:complications / Q000662:veterinary; D055728:Primary Myelofibrosis / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D012189:Retrospective Studies; D016019:Survival Analysis
D007166:Immunosuppressive Agents