title: Sustained G-->A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome.
abstract: Two full-length human immunodeficiency virus type 1 O sequences are described, one of which was hypermutated in all regions of the genome. This indicates that the intracellular [dTTP]/[dCTP] bias conducive to G-->A hypermutation may be sustained throughout the synthesis of minus-strand DNA. In turn, this suggests the possibility of mutation of host sequences.
authors.affiliation: Unité de Rétrovirologie Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France1.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Vartanian
authors.affiliation: Unité de Rétrovirologie Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France1.
authors.forename: Michel
authors.initials: M
authors.lastname: Henry
authors.affiliation: Unité de Rétrovirologie Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France1.
authors.forename: Simon
authors.initials: S
authors.lastname: Wain-Hobson
mesh_terms: D000595:Amino Acid Sequence; D004279:DNA, Viral / Q000096:biosynthesis; D015686:Gene Products, env / Q000737:chemistry; D016679:Genome, Viral; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D014158:Transcription, Genetic
chemical_list: D004279:DNA, Viral; D015686:Gene Products, env