[The role of EGF-stimulated epidermis in the regulation of wound healing].
Sluggish wounds are characterized by impaired proportions of proinflammatory cytokines, deficiency of fibrogenic growth factors, imbalance in the system of matrix metalloproteinases and their inhibitors this preventing reparation. The study was made of biopsies obtained from patients with sluggish wounds before the treatment, 5, 10 and 15 days after transplantation on the wound of allogenic EGF-stimulated cryopreserved epidermis. The wound closure with biologically active coat was followed by the reduction of expression of proinflammatory cytokines and return to their normal correlations, higher production of fibrogenic growth factors, restoration of balance in the expression of MMP-9 and TIMP-1/TIMP-2.
Ivanov
A A
AA
Research Institute of Molecular Medicine, I.M. Sechenov Moscow Medical Academy, 119881, Moscow.
Fedorov
D N
DN
Vasil'ev
A V
AV
Khodzhabekian
G V
GV
Ivashkin
A N
AN
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D004817:Epidermis / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis; D011817:Rabbits; D012867:Skin / Q000293:injuries*; D016038:Skin Transplantation / Q000473:pathology*; D014945:Wound Healing / Q000187:drug effects*
D016207:Cytokines; D004815:Epidermal Growth Factor; D020780:Matrix Metalloproteinase 9