[Compound RSA 11 beta-hydroxylation with Curvularia lunata].
Compound RSA 11 beta-Hydroxylation of Curvularia lunata was studied. The composition of hydroxylation products was analyzed. It was found that the conversion rate with protoplasts was increased conspicuously, the construction and quantity of hydroxylation products was not alteration, but the percentage was changed greatly. The 14 alpha-OH percentage of protoplasts was 3.03-fold than that of mycelia, the 11 alpha-OH percentage was decreased 60%, and the conversion ratio of 11 beta-OH was more 1.29-fold than that of the mycelia. It affected the percentage of hydroxylation products when 2 mg/mL polyoxins were added into the mycelia conversion system.
Wang
M
M
Tianjin University of Light Industry, Tianjin 300222, China. minwtj@263.net
Lu
F P
FP
Wang
F Q
FQ
Jiang
Y
Y
Du
L X
LX
D019326:17-alpha-Hydroxyprogesterone / Q000378:metabolism*; D000935:Antifungal Agents / Q000494:pharmacology; D001203:Ascomycota / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D001711:Biotransformation / Q000187:drug effects / Q000502:physiology; D006854:Hydrocortisone / Q000378:metabolism*; D006900:Hydroxylation / Q000187:drug effects; D025282:Mycelium / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011523:Protoplasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D011741:Pyrimidine Nucleosides / Q000494:pharmacology*
D000935:Antifungal Agents; D011741:Pyrimidine Nucleosides; C002457:polyoxin; D019326:17-alpha-Hydroxyprogesterone; D006854:Hydrocortisone