title: Behavior in Huntington's disease: dissociating cognition-based and mood-based changes.
abstract: The authors examined the relationship of three dimensions of behavioral change (Apathy, Depression, and Irritability) measured by the Problem Behaviors Assessment for Huntington's Disease (PBA-HD) to cognitive and motor indices of disease severity. The Apathy subscale was highly correlated with both cognitive and motor impairment; the Irritability and Depression subscales were not. The findings suggest that certain behavioral alterations are intrinsic to the evolution and progression of HD, whereas others are more variable and are independent of other indices of disease progression.
authors.affiliation: Cerebral Function Unit, Greater Manchester Neuroscience Center, Salford, United Kingdom. jennifer.thompson@man.ac.uk
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Thompson
authors.forename: Julie S
authors.initials: JS
authors.lastname: Snowden
authors.forename: David
authors.initials: D
authors.lastname: Craufurd
authors.forename: David
authors.initials: D
authors.lastname: Neary
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000339:Affect / Q000502:physiology*; D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition / Q000502:physiology*; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000523:psychology*; D007508:Irritable Mood / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D013060:Speech / Q000502:physiology