title: Combination of quinupristin-dalfopristin (Synercid) and rifampin is highly synergistic in experimental Staphylococcus aureus joint prosthesis infection.
abstract: We compared the efficacies of quinupristin-dalfopristin (Q-D; 30 mg/kg of body weight every 8 h) and vancomycin (60 mg/kg twice daily), alone or in combination with rifampin (10 mg/kg twice daily), in a rabbit model of methicillin-resistant Staphylococcus aureus knee prosthesis infection. In contrast to vancomycin, Q-D significantly reduced the mean log(10) CFU per gram of bone versus that for the controls. The combination of rifampin with either Q-D or vancomycin was significantly more effective than monotherapy.
authors.affiliation: INSERM EMI-U 9933, Hôpital Bichat-Claude Bernard, Paris, France.
authors.forename: Azzam
authors.initials: A
authors.lastname: Saleh-Mghir
authors.forename: Nourdine
authors.initials: N
authors.lastname: Ameur
authors.forename: Claudette
authors.initials: C
authors.lastname: Muller-Serieys
authors.forename: Farid
authors.initials: F
authors.lastname: Ismael
authors.forename: Françoise
authors.initials: F
authors.lastname: Lemaitre
authors.forename: Laurent
authors.initials: L
authors.lastname: Massias
authors.forename: Céline
authors.initials: C
authors.lastname: Feger
authors.forename: Rémy
authors.initials: R
authors.lastname: Bléton
authors.forename: Anne-Claude
authors.initials: AC
authors.lastname: Crémieux
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage*; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007595:Joint Prosthesis; D016106:Methicillin Resistance; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D011817:Rabbits; D012293:Rifampin / Q000008:administration & dosage*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D014018:Tissue Distribution; D014640:Vancomycin / Q000493:pharmacokinetics / Q000627:therapeutic use; D014769:Virginiamycin / Q000008:administration & dosage* / Q000031:analogs & derivatives
chemical_list: D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D014769:Virginiamycin; C113825:quinupristin; D014640:Vancomycin; D012293:Rifampin