BRCA1 and BRCA2 in hereditary breast cancer.
The hereditary breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2, have established roles in genome integrity maintenance and in the control of homologous recombination. Recent work has produced valuable insights into the mechanisms of action of the gene products. This review summarizes some of these advances, and attempts to place them in the context of known functions of the genes.
Scully
Ralph
R
Department of Hematology/Oncology, Cancer Biology Program, Beth Israel Deaconess Medical Center and Harvard Medical School, 77 Avenue Louis Pasteur, HIM 925, Boston, MA 02215, USA. rscully@caregroup.harvard.edu
Puget
Nadine
N
D020816:Amino Acid Motifs; D000818:Animals; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D030342:Genetic Diseases, Inborn / Q000235:genetics; D006801:Humans; D011995:Recombination, Genetic; D013329:Structure-Activity Relationship
D019313:BRCA1 Protein; D024682:BRCA2 Protein