title: Clavosolides A and B, dimeric macrolides from the Philippines sponge Myriastra clavosa.
abstract: A specimen of the sponge Myriastra clavosa from the Philippines contained two dimeric macrolides, clavosolides A and B. Clavosolide A is a symmetrical dimer, while clavosolide B is rendered unsymmetrical by the replacement of one of the methoxyl groups by a hydroxyl group. The structures of the clavosolides were elucidated by interpretation of spectroscopic data.
authors.affiliation: Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212, USA.
authors.forename: M Rama
authors.initials: MR
authors.lastname: Rao
authors.forename: D John
authors.initials: DJ
authors.lastname: Faulkner
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010679:Philippines; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D018942:Macrolides; C455699:clavosolide A; C455700:clavosolide B