title: A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis.
abstract: Xerotic skin is a pattern of reaction to a variety of disorders that have abnormalities of desquamation in common. This double-blind, randomized clinical trial investigated the effect of Lactinol (Pedinol Pharmaceuticals, Farmingdale, New York) versus Lac-Hydrin 12% (Bristol-Myers Squibb, Princeton, New Jersey) lotion in mild to moderate foot xerosis. Clinical assessment of xerosis was performed at baseline visit, and the designated sites were evaluated at 2 and 4 weeks after treatment began. Of the 53 patients enrolled, 18 were excluded from analysis. Although both treatment groups had significantly improved xerosis scores after 2 and 4 weeks of treatment, no statistically significant difference was observed. Of the 44% of patients who did express a preference, 72% preferred Lactinol, which may account for the 20% increase in its overall use in the study.
authors.affiliation: New York College of Podiatric Medicine, New York, NY 10035, USA.
authors.forename: Maureen B
authors.initials: MB
authors.lastname: Jennings
authors.forename: Loretta
authors.initials: L
authors.lastname: Logan
authors.forename: Donna M
authors.initials: DM
authors.lastname: Alfieri
authors.forename: Charles F
authors.initials: CF
authors.lastname: Ross
authors.forename: Susan
authors.initials: S
authors.lastname: Goodwin
authors.forename: Christine
authors.initials: C
authors.lastname: Lesczczynski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D004890:Erythema / Q000139:chemically induced; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy*; D006801:Humans; D019344:Lactic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000139:chemically induced; D000644:Quaternary Ammonium Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D000644:Quaternary Ammonium Compounds; D019344:Lactic Acid; C114389:Lac-Hydrin