Molecular analysis of cancer. An overview.
Human cancers are generally characterized by acquisition of a series of somatic mutations. Molecular techniques, such as those described in this volume, have been used to identify a plethora of chromosomal translocations and mutations associated with carcinogenesis. The analysis and comparison of the array of genetic changes occurring in malignancy will enable a move toward a better understanding of cancer development. This will eventually lead to the development of improved therapies tailored to take into account the cytogenetic and molecular characteristics of specific human cancers.
Mills
Ken
K
Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK.
D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008745:Methylation; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000503:physiopathology*; D020411:Oligonucleotide Array Sequence Analysis; D017422:Sequence Analysis, DNA / Q000379:methods; D019098:Telomerase / Q000378:metabolism
D019098:Telomerase