[Effects of radiation-ecological conditions and experimental hyperthyroid states on indicators of testis and prostate androgen receptors in rats].
Dose-dependent changes of the molecular characteristics on androgen receptor (AR) systems in gonads of male rats were studied at experimental L-thyroxine-induced states after low doses irradiation exposures in different reference points of 10-km Chernobyl zone. The data obtained suggest a generalized working mechanism of "oscillatorous changes" for contents, affinities and cooperative properties of AR to its natural ligands as a "mirror" reflecting some adaptational reactions in target cells that modulates their androgen-controlled biochemical activity.
Popov
E G
EG
Institute of Radiobiology of National Academy of Science of Belarus, Minsk, 220141, Belarus.
Kuts
F I
FI
Belousov
O L
OL
D000818:Animals; D002588:Cesium Radioisotopes; D013196:Dihydrotestosterone / Q000032:analysis*; D004307:Dose-Response Relationship, Radiation; D004463:Ecology; D006980:Hyperthyroidism / Q000139:chemically induced / Q000150:complications*; D008297:Male; D011210:Power Plants; D011467:Prostate / Q000737:chemistry / Q000528:radiation effects*; D018788:Radioactive Hazard Release; D051381:Rats; D011944:Receptors, Androgen / Q000032:analysis*; D012990:Soil Pollutants, Radioactive; D013737:Testis / Q000737:chemistry / Q000528:radiation effects*; D013974:Thyroxine; D013997:Time Factors; D014455:Ukraine
D002588:Cesium Radioisotopes; D011944:Receptors, Androgen; D012990:Soil Pollutants, Radioactive; D013196:Dihydrotestosterone; D013974:Thyroxine