title: Cerebellar aspergillosis: case report and literature review.
abstract: OBJECTIVE
  An unusual, but not unique, case of cerebellar aspergillosis associated with autologous peripheral blood stem cell transplantation for breast cancer is presented.
  
  
  METHODS
  A 45-year-old woman with breast cancer underwent chemotherapy and radiotherapy as well as autologous peripheral blood stem cell transplantation. She developed a cerebellar aspergillosis abscess that was treated successfully with two surgical resections.
  
  
  METHODS
  After removal of pus and the abscess wall, the patient received local application of amphotericin B (AmB). She received AmB 1 mg/kg/d for 3 months and itraconazole 100 mg/kg/d for 1 year. After 3 months of AmB treatment, magnetic resonance imaging revealed that disease had not recurred.
  
  
  CONCLUSIONS
  In cases of central nervous system aspergillosis, to increase the therapeutic efficiency, AmB can also be applied to the abscess cavity. Computed tomographic and contrast-enhanced magnetic resonance imaging scans play an important role in establishing early diagnosis in high-risk, immunocompromised patients.
authors.affiliation: Department of Neurosurgery, Gulhane Military Medical School, Ankara, Turkey. ersinerdogan@usa.net
authors.forename: Ersin
authors.initials: E
authors.lastname: Erdogan
authors.forename: Murat
authors.initials: M
authors.lastname: Beyzadeoglu
authors.forename: Fikret
authors.initials: F
authors.lastname: Arpaci
authors.forename: Bülent
authors.initials: B
authors.lastname: Celasun
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000209:etiology* / Q000628:therapy*; D001922:Brain Abscess / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D001943:Breast Neoplasms / Q000601:surgery; D002526:Cerebellar Diseases / Q000209:etiology* / Q000628:therapy*; D004322:Drainage; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D014182:Transplantation, Autologous
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B