title: Intratubular embryonal carcinoma.
abstract: Although intratubular embryonal carcinoma has been described adjacent to invasive embryonal carcinoma, to our knowledge it has not been reported as an isolated finding. We present in this report the histologic and immunohistochemical findings of 2 cases of intratubular embryonal carcinoma. One case was exclusively intratubular embryonal carcinoma without an invasive component in the same testis. A malignant mixed germ cell tumor in the contralateral testis had been previously excised. The second case is predominantly composed of intratubular embryonal carcinoma adjacent to a malignant mixed germ cell tumor. In one case, the intratubular embryonal carcinoma was immunoreactive for CD30, AE1/AE3, cytokeratin 7 focally, and p53. It was negative for cytokeratin 20, p21, and alpha-fetoprotein. These findings are strongly supportive of the opinion that intratubular embryonal carcinoma is the precursor of invasive embryonal carcinoma.
authors.affiliation: Division of Anatomic Pathology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9073, USA.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Rakheja
authors.forename: Mai P
authors.initials: MP
authors.lastname: Hoang
authors.forename: Suash
authors.initials: S
authors.lastname: Sharma
authors.forename: Jorge
authors.initials: J
authors.lastname: Albores-Saavedra
mesh_terms: D000328:Adult; D001457:Anion Exchange Protein 1, Erythrocyte / Q000032:analysis; D017920:Antiporters / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002278:Carcinoma in Situ / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D018236:Carcinoma, Embryonal / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D018237:Germinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D053552:Keratin-7; D007633:Keratins / Q000032:analysis; D017730:Ki-1 Antigen / Q000032:analysis; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D011230:Precancerous Conditions / Q000473:pathology; D013736:Testicular Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D001457:Anion Exchange Protein 1, Erythrocyte; D017920:Antiporters; D014408:Biomarkers, Tumor; C507497:KRT7 protein, human; D053552:Keratin-7; D017730:Ki-1 Antigen; C489237:SLC4A3 protein, human; D016159:Tumor Suppressor Protein p53; D007633:Keratins