title: Restriction of nutrient intake results in the increase of a specific Manduca sexta allatotropin (Manse-AT) mRNA in the larval nerve cord.
abstract: The Manduca allatotropin (Manse-AT) gene is expressed as three mRNAs that differ from each other by alternative splicing. The level of one of these mRNAs (RNA-3) is specifically increased in the nerve cord of last instar larvae that were starved, parasitized, or fed the ecdysteroid agonist RH-5992. Each of these treatments results in reduction of feeding and increased levels of juvenile hormone (JH). The normal decline in JH biosynthesis by the corpora allata does not occur in starved or RH-5992-fed larvae. The increase in RNA-3 levels has the capacity to increase the production of Manse-AT and two related peptides that may be part of the complex response of larvae to nutrient deprivation.
authors.affiliation: Department of Biomedical Sciences and the College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
authors.forename: Kyeong Yeoll
authors.initials: KY
authors.lastname: Lee
authors.forename: Frank M
authors.initials: FM
authors.lastname: Horodyski
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D004435:Eating; D005091:Exons / Q000235:genetics; D006834:Hydrazines / Q000494:pharmacology; D007301:Insect Hormones / Q000235:genetics / Q000378:metabolism*; D007306:Insecticides / Q000494:pharmacology; D007605:Juvenile Hormones / Q000378:metabolism; D007814:Larva / Q000187:drug effects / Q000235:genetics / Q000378:metabolism / Q000469:parasitology; D018402:Manduca / Q000737:chemistry / Q000254:growth & development* / Q000469:parasitology; D009417:Nerve Tissue / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D013217:Starvation
chemical_list: D006834:Hydrazines; D007301:Insect Hormones; D007306:Insecticides; D007605:Juvenile Hormones; D009479:Neuropeptides; D012333:RNA, Messenger; C050669:allatotropin; C082026:tebufenozide