title: A goniolens for clinical monitoring of the mouse iridocorneal angle and optic nerve.
abstract: OBJECTIVE
  Due to the increasing importance of mouse models and mouse genetics in ophthalmic research, we have developed a goniolens for mice.
  
  
  METHODS
  The size and basic design parameters of a human goniolens were adapted to the mouse eye.
  
  
  RESULTS
  The goniolens is straightforward to use and allows non-invasive visualization of the structures of the anterior chamber angle, including Schlemm's canal, trabecular meshwork, iris and anterior surface of the peripheral ciliary body. Goniophotography using the mouse lens allows documentation of anterior chamber angle abnormalities, and facilitates comparisons of changes to these structures in the same eye over time. In addition, high quality magnified views of the optic nerve, retinal vessels and posterior retina are easily obtained.
  
  
  CONCLUSIONS
  This goniolens is an important new tool for studying the genetic and clinical etiology of anterior segment dysgenesis and glaucoma in mice.
authors.affiliation: The Howard Hughes Medical Institute and The Jackson Laboratory, Bar Harbor, ME 04609, USA. rss@jax.org
authors.forename: Richard S
authors.initials: RS
authors.lastname: Smith
authors.forename: Donald
authors.initials: D
authors.lastname: Korb
authors.forename: Simon W M
authors.initials: SW
authors.lastname: John
mesh_terms: D000818:Animals; D000869:Anterior Eye Segment / Q000002:abnormalities; D002924:Ciliary Body / Q000033:anatomy & histology; D003315:Cornea / Q000033:anatomy & histology*; D004867:Equipment Design; D005124:Eye Abnormalities / Q000175:diagnosis; D005901:Glaucoma / Q000175:diagnosis; D006068:Gonioscopy / Q000295:instrumentation* / Q000379:methods; D007498:Iris / Q000033:anatomy & histology*; D007909:Lenses; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009900:Optic Nerve / Q000033:anatomy & histology*; D012160:Retina / Q000033:anatomy & histology; D012171:Retinal Vessels / Q000033:anatomy & histology; D014129:Trabecular Meshwork / Q000033:anatomy & histology*