Stereoselective syntheses of (+/-)-epibatidine analogues.
Stereoselective syntheses of (+/-)-epibatidine analogues 2, which contain the 8-azabicyclo [3.2.1]octane ring system, were achieved by using palladium-catalyzed cross-coupling reaction from 4 and the analgesic activity was tested by Mouse writhing antinociceptive assay.
Kim
Yong-Hyun
YH
College of Pharmacy, SungKyunKwan University, Suwon, Korea.
Won
Do-Youn
DY
Oh
Chang-Young
CY
Lee
Kee-Young
KY
Lee
Yiu-Suk
YS
Woo
Nam-Tae
NT
Park
Young-Ho
YH
Park
Hyun-Ju
HJ
Ham
Won-Hun
WH
D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018722:Nicotinic Agonists / Q000138:chemical synthesis* / Q000737:chemistry; D010147:Pain Measurement / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D018712:Analgesics, Non-Narcotic; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007202:Indicators and Reagents; D018722:Nicotinic Agonists; D011725:Pyridines; C082748:epibatidine