Chemokines: agents for the immunotherapy of cancer?
Chemokines, a superfamily of small cytokine-like molecules, regulate leukocyte transport in the body. In recent years, we have witnessed the transition of immunotherapeutic strategies from the laboratory to the bedside. Here, we review the role of chemokines in tumour biology and the development of the host's anti-tumour defence. We summarize the current knowledge of chemokine-receptor expression by relevant cellular components of the immune system and the role of their ligands in the organization of the antitumour immune response. Finally, we discuss recent findings which indicate that chemokines have therapeutic potential as adjuvants or treatments in antitumour immunotherapy, as well as remaining questions and perspectives for translating experimental evidence into clinical practice.
Homey
Bernhard
B
Departments of Dermatology and Radiation Oncology, Heinrich-Heine-University, D-40225 Düsseldorf, Germany. Bernhard.Homey@rz.uni-duesseldorf.de
Müller
Anja
A
Zlotnik
Albert
A
D000818:Animals; D018925:Chemokines / Q000502:physiology / Q000627:therapeutic use*; D016207:Cytokines / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000628:therapy*
D018925:Chemokines; D016207:Cytokines