title: Plasma adenosine concentration increases during exercise: a possible contributing factor in exercise-induced bronchoconstriction in asthma.
abstract: We investigated whether the level of plasma adenosine (ADO) changed during exercise and whether this could be related to exercise-induced bronchoconstriction. Baseline levels of ADO did not differ, but exercise resulted in higher ADO in patients with asthma than in healthy subjects (86 +/- 35 vs 59 +/- 16 nmol/L; P <.001). In patients with asthma, the increase in ADO was related to decreases in FEV(1) (r (2) = 0.475; P <.05) and SaO(2) (r (2) = 0.693; P <.05). These data suggest that adenosine might be involved in the development of exercise-induced bronchoconstriction.
authors.affiliation: Department of Pathophysiology, National Korányi Institute for Tuberculosis and Pulmonology, Budapest, Hungary.
authors.forename: Eva
authors.initials: E
authors.lastname: Vizi
authors.forename: Eva
authors.initials: E
authors.lastname: Huszár
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Csoma
authors.forename: György
authors.initials: G
authors.lastname: Böszörményi-Nagy
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Barát
authors.forename: Ildikó
authors.initials: I
authors.lastname: Horváth
authors.forename: Irén
authors.initials: I
authors.lastname: Herjavecz
authors.forename: Márk
authors.initials: M
authors.lastname: Kollai
mesh_terms: D000241:Adenosine / Q000097:blood*; D000293:Adolescent; D000328:Adult; D001250:Asthma, Exercise-Induced / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D016084:Bronchoconstriction; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D005082:Physical Exertion
chemical_list: D000241:Adenosine