[Severe pruriginous acne in dialysed renal failure. Diagnostic difficulties and efficacy of isotretinoin].
BACKGROUND
The occurrence of acne in dialysed renal failure patients has rarely been reported and the clinical characteristics and therapeutic issues rarely studied in these patients.


METHODS
Two men and two women, 33 to 56 years-old, with chronic renal failure and no past history of acne, developed severe acne under dialysis. The acne was excoriated in all cases and associated with prurigo-like lesions and intense pruritus, which made diagnosis difficult. Acne was profuse on the face and the trunk, but also on the neck (1 case) and the upper limbs (2 cases). No patient was taking acne-inducing substances. Various to therapies attempting to control pruritus were ineffective. However, anti-acne treatments (cyclines associated with local tretinoin in 1 case and oral isotreninoin in 3 cases) led to complete regression of the acne, pruritus and the prurigo-like lesions without relapse after a follow-up time of 4 months to 2 years.


CONCLUSIONS
Pruritus is frequent during renal failure. However, the occurrence of unexplained acne has only rarely been reported. Our patients' clinical picture was original, characterized by the late development, under dialysis, of severe and pruriginous acne, the pathogenesis of which is unknown. Because of the clinical and therapeutic implications (impaired quality of life, pigmentation or scarring and remarkable efficacy of oral isotretinoin) this clinical picture merits more attention, and the modalities for the prescription of isotretinoin in this context should be defined.
Grange
F
F
Service de Dermatologie, Hôpital Pasteur, 39 avenue de la Liberté, 68024 Colmar. florent.grange@libertysurf.fr
Mitschler
A
A
Genestier
S
S
Guillaume
J C
JC
D000152:Acne Vulgaris / Q000175:diagnosis / Q000188:drug therapy*; D000284:Administration, Oral; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011536:Prurigo / Q000175:diagnosis / Q000188:drug therapy*; D006435:Renal Dialysis
D015474:Isotretinoin