Glucocorticoid-induced hypertension: from mouse to man.
1. Adrenocorticotrophic hormone (ACTH) raises blood pressure in humans, sheep, rat and mouse. In rat and humans, but not sheep, the hypertension can be explained by glucocorticoid excess. 2. In both rat and humans, the hypertension is associated with a rise in cardiac output and renal vascular resistance. 3. In both rat and humans, the nitric oxide system is implicated in glucocorticoid hypertension. 4. In both rat and humans, hypertension due to naturally occurring glucocorticoids is not prevented by drugs that block classical glucocorticoid or mineralocorticoid receptors. 5. Abnormalities in glucocorticoid metabolism may contribute to some forms of 'essential' hypertension.
Whitworth
J A
JA
The John Curtin School of Medical Research, The Australian National University, Acton, Australian Capital Territory, Australia.
Schyvens
C G
CG
Zhang
Y
Y
Mangos
G J
GJ
Kelly
J J
JJ
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D005938:Glucocorticoids / Q000378:metabolism*; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology*; D009420:Nervous System / Q000503:physiopathology; D009569:Nitric Oxide / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism
D005938:Glucocorticoids; D011987:Receptors, Steroid; D009569:Nitric Oxide; D000324:Adrenocorticotropic Hormone