title: Exocytosis: the many masters of the exocyst.
abstract: The exocyst is a conserved eight-subunit complex involved in the docking of exocytic vesicles. The exocyst has now been identified as an effector for five small GTPases, including Sec4, Rho1, Rho3, Cdc42 and, most recently, RalA.
authors.affiliation: Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. jhlipsch@mail.med.upenn.edu
authors.forename: Joshua H
authors.initials: JH
authors.lastname: Lipschutz
authors.forename: Keith E
authors.initials: KE
authors.lastname: Mostov
mesh_terms: D000818:Animals; D005089:Exocytosis / Q000502:physiology*; D005656:Fungal Proteins; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D006801:Humans; D008322:Mammals; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins; D015003:Yeasts; D020764:cdc42 GTP-Binding Protein; D020691:rab GTP-Binding Proteins / Q000378:metabolism*; D020725:ral GTP-Binding Proteins; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: C103132:EXO70 protein, S cerevisiae; D005656:Fungal Proteins; C103131:SEC5 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins; D020558:GTP Phosphohydrolases; C492198:RALA protein, human; C064320:SEC4 protein, S cerevisiae; C074647:RHO3 protein, S cerevisiae; D020764:cdc42 GTP-Binding Protein; D020691:rab GTP-Binding Proteins; D020725:ral GTP-Binding Proteins; D020741:rho GTP-Binding Proteins