Lack of catheter infection by the efg1/efg1 cph1/cph1 double-null mutant, a Candida albicans strain that is defective in filamentous growth.
The molecular controls regulating the successful colonization of Candida albicans on foreign materials are not known. Here we show that a mutant C. albicans strain defective in filamentous growth and lacking the transcription factors Efg1p and Cph1p has a profoundly deficient potential for colonizing on polyurethane catheters.
Lewis
Russell E
RE
Department of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
Lo
Hsiu-Jung
HJ
Raad
Issam I
II
Kontoyiannis
Dimitrios P
DP
D002176:Candida albicans / Q000235:genetics* / Q000254:growth & development* / Q000648:ultrastructure; D002404:Catheterization / Q000009:adverse effects*; D015169:Colony Count, Microbial; D004268:DNA-Binding Proteins / Q000235:genetics*; D005656:Fungal Proteins / Q000235:genetics*; D005838:Genotype; D008855:Microscopy, Electron, Scanning; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D011140:Polyurethanes; D014157:Transcription Factors / Q000235:genetics*
C090837:CPH1 protein, Candida albicans; D004268:DNA-Binding Proteins; C121438:EFG1 protein, Candida albicans; D005656:Fungal Proteins; D011140:Polyurethanes; D014157:Transcription Factors