Inhibition of carbonic anhydrase in the lens does not induce myopia in cynomolgus monkeys.
Refraction was measured in eyes of cynomolgus (Macaca irus) monkeys, before and during continuous intravenous infusion of large doses of the carbonic anhydrase (CA) inhibitors acetazolamide and ethoxzolamide. No changes of refraction were seen. Therefore, inhibition of CA in lens, cornea and retina does not appear to be the cause of the transient myopia and associated symptoms, occasionally observed in patients treated with CA inhibitors.
Wistrand
P J
PJ
Department of Ophthalmology, Akademiska Sjukhuset, University of Uppsala, Sweden. Per.Wistrand@neuro.uu.se
D000086:Acetazolamide / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D002256:Carbonic Anhydrases / Q000378:metabolism*; D003315:Cornea / Q000187:drug effects / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D005016:Ethoxzolamide / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D007262:Infusions, Intravenous; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D007908:Lens, Crystalline / Q000187:drug effects* / Q000201:enzymology*; D008252:Macaca fascicularis; D009216:Myopia / Q000139:chemically induced; D012029:Refraction, Ocular / Q000187:drug effects*; D012160:Retina / Q000187:drug effects / Q000201:enzymology
D002257:Carbonic Anhydrase Inhibitors; D007527:Isoenzymes; D002256:Carbonic Anhydrases; D000086:Acetazolamide; D005016:Ethoxzolamide