T(H)1 and T(H)2 cells: a historical perspective.
Demonstration of the existence and functions of T helper (T(H))1 and T(H)2 cells has had an enormous impact on basic and applied immunology. T(H)1 and T(H)2 cells have a crucial role in balancing the immune response. In this article, I attempt to trace the historical events contributing to the development of the T(H)1/T(H)2 concept, the current state of play, and briefly discuss the future prospects for the field.
Liew
Foo Y
FY
Department of Immunology and Bacteriology, University of Glasgow, UK. f.y.liew@clinmed.gla.ac.uk
D000486:Allergy and Immunology / Q000266:history*; D000818:Animals; D001327:Autoimmune Diseases / Q000266:history / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D049673:History, 20th Century; D006801:Humans; D007239:Infections / Q000266:history / Q000276:immunology; D051379:Mice; D018448:Models, Immunological; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*