title: [Leptospirosis in children of Libreville: difficult diagnosis, apropos of 1 case].
abstract: Leptospirosis is a widespread zoonosis, which is diagnosed less frequently in children than might be expected from the level of exposure to hazards, especially in tropical areas. A 15 1/2-year-old Gabonese boy was admitted following five days of fever, headache, myalgia, abdominal pain, diarrhea, intestinal bleeding, jaundice and conjunctival suffusion. Laboratory data showed abnormal liver and renal function tests, and diagnosis of Plasmodium falciparum malaria was confirmed by thin blood smear. The patient did not clinically improve despite antimalarial treatment and then leptospirosis was suspected. Serologic tests were performed and leptospirosis was later confirmed. Antibiotic treatment (cefuroxim) was given. The outcome was good, liver and renal tests returned to normal in a few days. In tropical area, leptospirosis should be considered in children who are diagnosed with either an unexplained fever, a pseudo-influenza syndrome, or jaundice with hepatorenal involvement and gastrointestinal bleeding.
authors.affiliation: Service de pédiatrie générale, Hôpital pédiatrique d'Owendo, BP 1208, Libreville, Gabon. jkoko@assala.com
authors.forename: J
authors.initials: J
authors.lastname: Koko
authors.forename: A
authors.initials: A
authors.lastname: Moussavou
authors.forename: C
authors.initials: C
authors.lastname: Orima
authors.forename: C
authors.initials: C
authors.lastname: Seilhan
authors.forename: A
authors.initials: A
authors.lastname: Lemba-Abaka
authors.forename: S
authors.initials: S
authors.lastname: Damas
mesh_terms: D015746:Abdominal Pain; D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood; D002444:Cefuroxime / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005334:Fever; D005681:Gabon; D006471:Gastrointestinal Hemorrhage; D006801:Humans; D007919:Leptospira / Q000276:immunology; D007922:Leptospirosis / Q000175:diagnosis* / Q000188:drug therapy; D016778:Malaria, Falciparum; D008297:Male
chemical_list: D000907:Antibodies, Bacterial; D002511:Cephalosporins; D002444:Cefuroxime