title: Dementia at old age: a clinical end-point of atherosclerotic disease.
abstract: The main causes of dementia at old age are Alzheimer's disease and vascular dementia. The clinical presentations of late-onset Alzheimer's disease and vascular dementia can barely be differentiated. This clinical observation is supported by pathological findings. Late-onset dementia should be considered a multifactorial disease, in which both vascular factors and amyloid dispositions contribute to cognitive decline.
authors.affiliation: Section of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands.
authors.forename: G J
authors.initials: GJ
authors.lastname: Blauw
authors.forename: E L
authors.initials: EL
authors.lastname: Bollen
authors.forename: M A
authors.initials: MA
authors.lastname: van Buchem
authors.forename: R G
authors.initials: RG
authors.lastname: Westendorp
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000150:complications / Q000503:physiopathology; D015984:Causality; D015140:Dementia, Vascular / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D023381:Endpoint Determination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014481:United States / Q000453:epidemiology