Increased chemokine receptor expression and the infiltration of lymphoid organs.
Lymphocyte passage across endothelium into lymph nodes and Peyer's patches is a multistep process that involves selectin-supported rolling, followed by a triggering event, and then firm integrin-mediated adhesion. The combined actions of adhesion molecules and chemokines largely determine the migratory behavior of lymphocytes. Chemokines are known to mediate their effects through 7 transmembrane-domain G-protein-coupled receptors. Here, we review the role of chemokines and their receptors in lymphocyte's migration into lymphoid organs.
Hasegawa
H
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First Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Japan. hitoshih@m.ehime-u.ac.jp
D002465:Cell Movement; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology; D008214:Lymphocytes / Q000502:physiology*; D008221:Lymphoid Tissue / Q000473:pathology*; D019707:Receptors, Chemokine / Q000502:physiology*
D019707:Receptors, Chemokine