title: Blockade of adenosine A1 receptors in the posterior cingulate cortex facilitates memory in rats.
abstract: Male Wistar rats were bilaterally implanted with indwelling cannulae in the caudal region of the posterior cingulate cortex. After recovery, animals were trained in a step-down inhibitory avoidance task (3.0-s, 0.4-mA foot shock) and received, immediately after training, a 0.5-microl infusion of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA; 1, 50 or 100 nM) or of the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; 1, 25 or 50 nM). Animals were tested twice, 1.5 h and, again, 24 h after training, in order to examine the effects of these agents on short- and long-term memory, respectively. Only 50-nM DPCPX was effective in altering memory, promoting a facilitation. These results suggest that adenosine A1 receptors in the posterior cingulate cortex inhibit memory consolidation in a way that their blockade facilitates memory for inhibitory avoidance in rats.
authors.affiliation: Laboratório de Enzimologia e Centro de Memória, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Grace S
authors.initials: GS
authors.lastname: Pereira
authors.forename: Tadeu
authors.initials: T
authors.lastname: Mello e Souza
authors.forename: Elsa R C
authors.initials: ER
authors.lastname: Vinadé
authors.forename: Humberto
authors.initials: H
authors.lastname: Choi
authors.forename: Cristina
authors.initials: C
authors.lastname: Rodrigues
authors.forename: Ana M O
authors.initials: AM
authors.lastname: Battastini
authors.forename: Iván
authors.initials: I
authors.lastname: Izquierdo
authors.forename: João J F
authors.initials: JJ
authors.lastname: Sarkis
authors.forename: Carla D
authors.initials: CD
authors.lastname: Bonan
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006179:Gyrus Cinguli / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008568:Memory / Q000187:drug effects*; D058915:Purinergic P1 Receptor Antagonists; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000502:physiology; D012153:Retention, Psychology / Q000187:drug effects; D014970:Xanthines / Q000494:pharmacology*
chemical_list: D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1; D014970:Xanthines; C048599:N(6)-cyclopentyladenosine; C051360:1,3-dipropyl-8-cyclopentylxanthine; D000241:Adenosine