Fatty acid esters of juvenoid alcohols as insect hormonogen agents (juvenogens).
A series of 8 new juvenogens (3--10) was prepared starting from a pair of isomeric insect juvenile hormone bioanalogues ( and ). The biological activity of the juvenogens -- was tested for their effect on reproduction of the blowfly Neobellieria (Sarcophaga) bullata and for the juvenilizing activity on the termite Prorhinotermes simplex. Results of biological screening are important in structure--activity studies and promising for potential practical application of some of the juvenogens studied, especially against termites.
Wimmer
Zdenek
Z
Department of Natural Products, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo námestí 2, CZ-16610 Prague 6, Czech Republic. wimmer@uochb.cas.cz
Saman
David
D
Kuldová
Jelena
J
Hrdý
Ivan
I
Bennettová
Blanka
B
D000818:Animals; D004175:Diptera / Q000187:drug effects / Q000254:growth & development; D004952:Esters / Q000138:chemical synthesis / Q000494:pharmacology; D005227:Fatty Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020049:Isoptera / Q000187:drug effects / Q000254:growth & development; D007605:Juvenile Hormones / Q000138:chemical synthesis* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D008726:Methoprene / Q000031:analogs & derivatives / Q000494:pharmacology; D018716:Molecular Mimicry; D010053:Ovary / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects; D013329:Structure-Activity Relationship
D004952:Esters; D005227:Fatty Acids; D007306:Insecticides; D007605:Juvenile Hormones; D008726:Methoprene