Expression of interleukin-10 is inversely correlated with distant metastasis of renal cell carcinoma.
Interleukin-10 (IL-10) is an immunomodulative cytokine produced by T cells, B cells, and monocytic cells. The significance of IL-10 and IL-10R expression in renal cell carcinoma (RCC) has not been well characterized. In this study, we assessed the correlation between IL-10 gene expression and its pathological significance in 44 RCC specimens. The patients with IL-10 gene expression showed a decreased incidence of metastasis compared to those without IL-10 gene expression. The expression of IL-10 was correlated with vascular endothelial growth factor (VEGF)-A gene expression. These findings suggest that IL-10 gene expression plays some roles in the metastasis of RCC.
Uwatoko
Noriyasu
N
Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan.
Tokunaga
Tetsuji
T
Hatanaka
Hiroyuki
H
Osada
Hideo
H
Kawakami
Tsutomu
T
Yamazaki
Hitoshi
H
Abe
Yoshiyuki
Y
Kijima
Hiroshi
H
Ueyama
Yoshito
Y
Nakamura
Masato
M
D042702:Angiopoietin-2; D000818:Animals; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000556:secondary; D016228:Endothelial Growth Factors / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D007124:Immunoenzyme Techniques; D016753:Interleukin-10 / Q000235:genetics* / Q000378:metabolism; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D051379:Mice; D016513:Mice, SCID; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D018123:Receptors, Interleukin / Q000235:genetics / Q000378:metabolism; D053701:Receptors, Interleukin-10; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019700:Thrombospondin 1 / Q000235:genetics / Q000378:metabolism; D019699:Thrombospondins / Q000235:genetics / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A; D000099262:Thrombospondin 2
D042702:Angiopoietin-2; D016228:Endothelial Growth Factors; D016753:Interleukin-10; D011506:Proteins; D012333:RNA, Messenger; D018123:Receptors, Interleukin; D053701:Receptors, Interleukin-10; D019700:Thrombospondin 1; D019699:Thrombospondins; D042461:Vascular Endothelial Growth Factor A; D000099262:Thrombospondin 2