N-arylation of primary and secondary aliphatic amines on solid supports.
A general and mild method for the N-arylation of primary and secondary aliphatic amines is reported. Copper acetate, triethylamine mediated C/N cross-coupling reaction of arylboronic acids at room temperature to solid-supported primary and secondary amines gave good to excellent yields of the desired N-arylated products.
Combs
Andrew P
AP
Chemical and Physical Sciences Department, DuPont Pharmaceuticals Company, Experimental Station, P.O. Box 80500, Wilmington, Delaware 19880-0500, USA.
Tadesse
Seifu
S
Rafalski
Maria
M
Haque
Tasir S
TS
Lam
Patrick Y S
PY
D000588:Amines / Q000138:chemical synthesis*; D002625:Chemistry, Organic / Q000379:methods; D020650:Combinatorial Chemistry Techniques
D000588:Amines