Platelet adhesion and aggregation and fibrin formation in flowing blood: a historical contribution by Giulio Bizzozero.
At the occasion of the first centennial of Giulio Bizzozero's death, the modern readers' attention is addressed to some ingenious experiments Bizzozero performed in Turin, Italy, around 1880. He discovered and carefully described blood platelet function in flowing conditions and the relationship between platelet adhesion to an artificial surface, aggregation and subsequent fibrin formation and deposition on activated platelet membrane. Bizzozero challenged contemporary concepts involving leukocytes in blood coagulation, but concluded that participation of blood platelets and white cells in fibrin formation was conceivable.
de Gaetano
Giovanni
G
Center for High Technology Research and Education in Biomedical Sciences, Catholic University, 861 Campobasso, Italy. degaetano@cotir.it
Cerletti
Chiara
C
D000818:Animals; D005337:Fibrin / Q000096:biosynthesis; D006405:Hematology / Q000266:history*; D018056:Hemorheology / Q000266:history*; D049672:History, 19th Century; D006801:Humans; D007558:Italy; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation
D005337:Fibrin