title: New roles for old holes: ion channel function in aquaporin-1.
abstract: Mammalian aquaporins are part of the diverse major intrinsic protein family of water and solute channels. Intriguing links exist in structural and functional properties between aquaporins and ion channels. A novel role for aquaporin-1 as a gated ion channel reshapes our current views of this ancient family of transmembrane channel proteins.
authors.affiliation: Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85724-5051, USA.
authors.forename: Andrea J
authors.initials: AJ
authors.lastname: Yool
authors.forename: Alan M
authors.initials: AM
authors.lastname: Weinstein
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D051398:Aquaporin 1; D020346:Aquaporins / Q000737:chemistry* / Q000378:metabolism*; D001789:Blood Group Antigens; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D014867:Water / Q000378:metabolism*
chemical_list: C496020:AQP1 protein, human; D020346:Aquaporins; D001789:Blood Group Antigens; D014867:Water; D051398:Aquaporin 1