Primary monotypic epithelioid angiomyolipoma of bone.
OBJECTIVE
Monotypic epithelioid angiomyolipoma is a distinct and definable variant of angiomyolipoma, composed of monomorphous epithelioid cells that show HMB45 immunoreactivity. Angiomyolipoma, including its morphological variants, belongs to the family of perivascular epithelioid cell tumour.


RESULTS
The tumour was examined using immunohistochemical staining and by transmission electron microscopy. Neoplastic cells showed a cytoplasmic granular positivity for HMB45.


CONCLUSIONS
Extrarenal angiomyolipomas are rare and, to the best of our knowledge, this is the first reported case of a primary monotypic epithelioid angiomyolipoma of bone in a patient without evidence of tuberous sclerosis.
Insabato
L
L
Dipartimento di Anatomia Patologica, Facoltà di Medicina, Università Federico II, Napoli, Italy. insabato@unina.it
De Rosa
G
G
Terracciano
L M
LM
Fazioli
F
F
Di Santo
F
F
Rosai
J
J
D000328:Adult; D018207:Angiomyolipoma / Q000378:metabolism / Q000473:pathology*; D000951:Antigens, Neoplasm; D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology*; D015622:Epithelioid Cells / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000032:analysis
D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins