Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication.
The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.
Allen
Todd M
TM
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA.
Mortara
Lorenzo
L
Mothé
Bianca R
BR
Liebl
Max
M
Jing
Peicheng
P
Calore
Briana
B
Piekarczyk
Marian
M
Ruddersdorf
Richard
R
O'Connor
David H
DH
Wang
X
X
Wang
Chenxi
C
Allison
David B
DB
Altman
John D
JD
Sette
Alessandro
A
Desrosiers
Ronald C
RC
Sutter
Gerd
G
Watkins
David I
DI
D016915:AIDS Vaccines / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D015658:HIV Infections / Q000517:prevention & control; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D008251:Macaca; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014611:Vaccination; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology; D014616:Vaccinia virus / Q000235:genetics; D019562:Viral Load; D014779:Virus Replication
D016915:AIDS Vaccines; D019444:Vaccines, DNA; C421254:human immunodeficiency virus type 1 Tat vaccine