title: Flashlamp pulsed dye laser and argon-pumped dye laser in the treatment of port-wine stains: a clinical and histological comparison.
abstract: BACKGROUND
  Port-wine stains (PWS) are congenital vascular malformations occurring in 0.3% of children. The pulsed dye laser is a well established treatment for PWS.
  
  
  OBJECTIVE
  To compare, clinically and histologically, the effects of the flashlamp pulsed dye laser with the argon-pumped dye laser in the treatment of PWS.
  
  
  METHODS
  Thirty patients were treated on two to four test areas with both laser types using different energy fluences. A flashlamp pulsed dye laser with 0.45 ms pulse duration and a spot size of 5 mm was compared with an argon-pumped dye laser, with a spot size of 1 mm delivered with a robotic scanning laser handpiece (Hexascan) and 70-190 ms pulse duration. Both were tuned to 585 nm. Twelve weeks later the degree of lightening was evaluated and biopsies were taken. To count the vessels the skin sections were stained with CD34 using an immunohistochemical technique. The vessels were divided into three groups by diameter (d): d < 10 microm, 10 < or = d < 20 microm, d > or = 20 microm.
  
  
  RESULTS
  The clinical results showed a significantly better lightening using the flashlamp pulsed dye laser than with the argon-pumped dye laser. The histological results showed a significant decrease in the number of vessels of diameter larger than 20 microm in treated compared with untreated lesions. We found no histological difference in the number of vessels between the two laser treatments. However, there was a tendency towards more small vessels (diameter < 10 microm) after one treatment with the flashlamp pulsed dye laser compared with untreated PWS.
  
  
  CONCLUSIONS
  The flashlamp pulsed dye laser is clinically superior to the argon-pumped dye laser in the treatment of PWS.
authors.affiliation: Department of Dermatology, Karolinska Hospital, S-171 76 Stockholm, Sweden. desiree.edstrom@ks.se
authors.forename: D W
authors.initials: DW
authors.lastname: Edström
authors.forename: M A
authors.initials: MA
authors.lastname: Hedblad
authors.forename: A M
authors.initials: AM
authors.lastname: Ros
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D008297:Male; D008875:Middle Aged; D019339:Port-Wine Stain / Q000473:pathology / Q000601:surgery*; D012880:Skin Pigmentation; D016896:Treatment Outcome