In vitro antifungal susceptibilities of Trichosporon species.
The in vitro activities of amphotericin B, itraconazole, fluconazole, voriconazole, posaconazole, and ravuconazole against 39 isolates of Trichosporon spp. were determined by the NCCLS M27-A microdilution method. The azoles tested appeared to be more potent than amphotericin B. Low minimal fungicidal concentration/MIC ratios were observed for voriconazole, posaconazole, and ravuconazole, suggesting fungicidal activity.
Paphitou
Niki I
NI
Laboratory for Mycology Research, Center for the Study of Emerging and Re-Emerging Pathogens, Division of Infectious Diseases, University of Texas-Houston Medical School, Houston, Texas 77030, USA. Elpida-Niki.I.Paphitou@uth.tmc.edu
Ostrosky-Zeichner
Luis
L
Paetznick
Victor L
VL
Rodriguez
Jose R
JR
Chen
Enuo
E
Rex
John H
JH
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D014250:Trichosporon / Q000187:drug effects*
D000935:Antifungal Agents; D001393:Azoles; D000666:Amphotericin B