The effect of ionizing radiation on some derivatives of 1,4-dihydropyridine in the solid state.
The effect of gamma and beta radiation in doses between 10 and 100 kGy on physico-chemical properties of four derivatives of 1,4-dihydropyridine (nifedipine, nitrendipine, felodipine and nimodipine) in the solid state was analysed. A number of qualitative and quantitative methods such as UV, IR, TLC, GLC, DSC, EPR as well as organoleptic and gravimetric analysis were used to determine and analyse any changes resulting from irradiation. In order to determine the effectiveness of sterilization with ionizing radiation of doses from 10 to 25 kGy, various microbiological tests were used. It was established that only doses 10-20 kGy of both kinds of radiation ensure total sterilization without any degradation of physico-chemical properties of the compounds studied. For the doses 50-100 kGy a decrease in the content of the compounds, appearance of the products of their decomposition and changes in the melting point and IR spectra appeared. Felodipine (with chlorophenyl substituent) was found to be much more sensitive to ionising radiation than nifedipine, nitrendipine and nimodipine (all with nitrophenyl substituent).
Marciniec
B
B
Department of Pharmaceutical Chemistry, Karol Marcinkowski University of Medical Sciences, Grunwaldzka 6, Poznan 60-780, Poland.
Jaroszkiewicz
E
E
Ogrodowczyk
M
M
D001610:Beta Particles; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000528:radiation effects; D004095:Dihydropyridines / Q000737:chemistry / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C038806:1,4-dihydropyridine