title: Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase.
abstract: Telomeric G-rich single-stranded DNA can adopt a G-tetraplex structure which has been shown to inhibit telomerase activity. We have examined benzoindoloquinolines derivatives for their ability to stabilize an intramolecular G-quadruplex. The increase in T(m) value of the G-quadruplex was associated with telomerase inhibition in vitro.
authors.affiliation: Laboratoire de Biophysique, Muséum National d'Histoire Naturelle, INSERM U 201, CNRS UMR 8646, 43 rue Cuvier, 75231 Paris cedex 05, France.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Alberti
authors.forename: Philippe
authors.initials: P
authors.lastname: Schmitt
authors.forename: Chi-Hung
authors.initials: CH
authors.lastname: Nguyen
authors.forename: Christian
authors.initials: C
authors.lastname: Rivalle
authors.forename: Magali
authors.initials: M
authors.lastname: Hoarau
authors.forename: David S
authors.initials: DS
authors.lastname: Grierson
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mergny
mesh_terms: D004247:DNA / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry*; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D011804:Quinolines / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D019914:Taq Polymerase / Q000037:antagonists & inhibitors / Q000737:chemistry; D019098:Telomerase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D016615:Telomere / Q000201:enzymology
chemical_list: D004277:DNA, Single-Stranded; D008024:Ligands; D011804:Quinolines; D006147:Guanine; D004247:DNA; D019914:Taq Polymerase; D019098:Telomerase