Beneficial effects of fructose 1,6-diphosphate on hemorrhagic shock in rats.
OBJECTIVE: To investigate the effects of fructose 1,6-diphosphate (FDP) on experimental hemorrhagic shock in rats. METHODS: Sixty rats were randomly divided into three groups: the normal saline control group (group A), the 5% glucose solution control group (group B) and the 5% FDP solution treated group (group C). Shock models were made by bloodletting until the mean arterial pressure (MAP) reduced to 39.75 mmHg (1 mmHg=0.133 kPa) for 60 minutes, and then normal saline, 5% glucose and FDP were given to the rats, respectively. RESULTS: FDP could significantly increase MAP and the survival rate, elevate pH value, partial oxygen pressure (PaO(2)) and superoxide dismutase (SOD) activity, and decrease partial carbon dioxide pressure (PaCO(2)) and malondialdehyde (MDA) in arterial blood of the shocked animals. CONCLUSIONS: It suggests that FDP has a good protective effect on hemorrhagic shock by improving tissue metabolism and preventing acidosis and tissue injury caused by free radicals.
Zhou
Yuanda
Y
Department of Clinical Pharmacology, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China.
Wang
Pilong
P
Lei
Ziqiang
Z
He
Haixia
H
Zhu
Zhiben
Z