title: Comparative antibiotic resistance of diarrheal pathogens from Vietnam and Thailand, 1996-1999.
abstract: Antimicrobial resistance rates for shigella, campylobacter, nontyphoidal salmonella, and enterotoxigenic Escherichia coli were compared for Vietnam and Thailand from 1996 to 1999. Resistance to trimethoprim-sulfamethoxazole, ampicillin, chloramphenicol, and tetracycline was common. Quinolone resistance remains low in both countries, except among campylobacter and salmonella organisms in Thailand. Nalidixic acid resistance among salmonellae has more than doubled since 1995 (to 21%) in Thailand but is not yet documented in Vietnam. Resistance to quinolones correlated with resistance to azithromycin in both campylobacter and salmonella in Thailand. This report describes the first identification of this correlation and its epidemiologic importance among clinical isolates. These data illustrate the growing magnitude of antibiotic resistance and important differences between countries in Southeast Asia.
authors.affiliation: Armed Forces Research Institute of Medical Science, Bangkok, Thailand. isenbargerdw@hotmail.com
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Isenbarger
authors.forename: Charles W
authors.initials: CW
authors.lastname: Hoge
authors.forename: Apichai
authors.initials: A
authors.lastname: Srijan
authors.forename: Chittima
authors.initials: C
authors.lastname: Pitarangsi
authors.forename: Niyada
authors.initials: N
authors.lastname: Vithayasai
authors.forename: Ladaporn
authors.initials: L
authors.lastname: Bodhidatta
authors.forename: Kimberly W
authors.initials: KW
authors.lastname: Hickey
authors.forename: Phung Dac
authors.initials: PD
authors.lastname: Cam
mesh_terms: D042462:4-Quinolones; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D003967:Diarrhea / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007223:Infant; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D013785:Thailand / Q000453:epidemiology; D014744:Vietnam / Q000453:epidemiology
chemical_list: D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D018942:Macrolides