Acute effects of pentobarbital, thiopental and urethane on lung oedema induced by alpha-naphthythiourea (ANTU).
This study was designed to investigate the possible participation of urethane, pentobarbital sodium and thiopental sodium anaesthesia in the lung oedema induced by alpha-naphthylthiourea (ANTU), which is a well known noxious chemical agent in the lung. ANTU when injected intraperitoneally (i.p.) into rats (10 mg x kg (-1) i.p.) produced lung oedema as indicated by an increase in lung weight/body weight (LW/BW) ratio and pleural effusion (PE) reaching a maximum within 4 h. Administration of urethane prior to ANTU, at doses of 100 and 200mg(100g)(-1), elicited a significant and dose-dependent inhibition in LW/BW ratio and PE. Thiopental sodium at doses of 25, 50 mg x kg (-1), also produced a significant and dose-dependent inhibition of both parameters. Prior i.p. injection of pentobarbital sodium at a dose of 40 mg x kg (-1) elicited a significant inhibition in both parameters. These results suggest that i.p. urethane, thiopental sodium and pentobarbital sodium pretreatment have a prophylactic effect on ANTU-induced lung injury in rats. The possible role of the anaesthetics in lung oedema induced by ANTU and the possible underlying mechanisms are discussed.
Sipahi
Emine
E
Department of Pharmacology, Faculty of Medicine, Karaelmas University, Zonguldak, Turkey. esipahi@drsiphai.com
Ustün
Hüseyin
H
Niyazi Ayoglu
Ferruh
F
D000818:Animals; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010424:Pentobarbital / Q000627:therapeutic use*; D010996:Pleural Effusion / Q000139:chemically induced / Q000517:prevention & control; D011654:Pulmonary Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D013874:Thiopental / Q000627:therapeutic use*; D013890:Thiourea / Q000031:analogs & derivatives* / Q000633:toxicity*; D014520:Urethane / Q000627:therapeutic use*
D006993:Hypnotics and Sedatives; D014520:Urethane; D013890:Thiourea; D010424:Pentobarbital; D013874:Thiopental; C005277:alpha-naphthyl thiourea