Basal forebrain infusions impair delayed-non-match-to-sample radial arm maze performance.
Direct site infusion of drugs into the brain is a powerful tool for examining the function of specific brain regions. While comparing the effects of various drugs injected into distinct regions of the basal forebrain on cognitive and motor endpoints, we observed that the ventral pallidum (VP) appeared to be sensitive to vehicle control infusions when cognitive indices were measured. To characterize this initial observation, the present study examined the effects of vehicle infusions into the VP on performance of a delayed-non-match-to-sample (DNMTS) radial arm maze (RAM) task. A within-subjects design was used. Male Sprague-Dawley rats were trained to perform this task with a 1-h delay imposed between the fourth and fifth arm selection. Following acquisition, animals were implanted with bilateral, indwelling cannulae positioned over the VP. Following surgery, maze performance was reestablished and rats were given one of five intra-VP treatments (two sham and three vehicle infusions) in counterbalanced order. Each rat received one treatment a week, on the third day of five consecutive testing days each week. Vehicle, but not sham, treatments produced deficits on the day of treatment and on two subsequent testing days. These findings demonstrate a persistent sensitivity of the VP to fluid perturbation and, when contrasted with the literature for other basal forebrain regions, it appears that this effect is unique.
Chrobak
James J
JJ
Department of Pharmacology and Experimental Therapeutics, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA.
Napier
T Celeste
TC
D000818:Animals; D007260:Infusion Pumps / Q000009:adverse effects; D015918:Infusion Pumps, Implantable / Q000009:adverse effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology*; D016548:Prosencephalon / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley