A novel dic(1;10) in a patient with myelodysplastic syndrome.
We report on a case of refractory anemia with trilineage dysplasia and an unbalanced der(1)t(1;10) that resulted in trisomy of the long arm of chromosome 1 (1q) and monosomy of the short arm of chromosome 10 (10p). Fluorescence in situ hybridization showed that the rearranged chromosome contained the centromeres of both chromosomes 1 and 10, leading to a dic(1;10). To our knowledge, a dicentric chromosome involving chromosomes 1 and 10 has never been described in hematological malignancies.
Sambani
Constantina
C
Laboratory of Health Physics & Environmental Hygiene, NCSR Demokritos, Athens, Greece. csambani@mail.demokritos.gr
La Starza
Roberta
R
Stavropoulou
Chryssa
C
Manola
Kalliopi N
KN
Harhalakis
Nicholas
N
Mecucci
Cristina
C
D000328:Adult; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D009006:Monosomy; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D014314:Trisomy