Development and characterization of solid lipid nanoparticles loaded with magnetite.
This paper describes the preparation of colloidal lipid particles containing magnetite from warm emulsions. A two step method was used to obtain the nanoparticles: (i) formulation of a transparent phase by heating a O/W emulsion (aqueous surfactant solution melted with a lipid phase, containing the ethyl oleate and soybean lecithin) in which modified lipophilic magnetite is incorporated, and (ii) preparation of the nanoparticles by dispersing the warm transparent phase in cold water (7 degrees C) under mechanical stirring. The latter method gives spherical nanoparticles of a mean size of 62 nm measured by Photon Correlation Spectroscopy and Transmission Electronic Microscopy. The magnetite entrapment efficiency was determined by use of a magnetophoretic sedimentation method.
Igartua
M
M
Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country (UPV-EHU), Paseo de la Universidad no. 7, 01006 Vitoria-Gasteiz, Spain.
Saulnier
P
P
Heurtault
B
B
Pech
B
B
Proust
J E
JE
Pedraz
J L
JL
Benoit
J P
JP
D003102:Colloids; D003287:Contrast Media / Q000737:chemistry; D052203:Ferrosoferric Oxide; D007501:Iron / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D036103:Nanotechnology / Q000379:methods*; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D017785:Photons; D013057:Spectrum Analysis
D003102:Colloids; D003287:Contrast Media; D008055:Lipids; D010087:Oxides; D007501:Iron; D052203:Ferrosoferric Oxide