title: New highly active taxoids from 9 beta-dihydrobaccatin-9,10-acetals.
abstract: To synthesize new highly active taxoids, we designed and synthesized 9 beta-dihydro-9,10-acetal taxoids. In vitro study of these analogues clearly showed them to be more potent than docetaxel.
authors.affiliation: Medicinal Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd, Tokyo R&D Center, 16-13 Kita-kasai 1-Chome Edogawa-ku, Tokyo 134-8630, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishiyama
authors.forename: Shin
authors.initials: S
authors.lastname: Iimura
authors.forename: Satoru
authors.initials: S
authors.lastname: Ohsuki
authors.forename: Kouichi
authors.initials: K
authors.lastname: Uoto
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Terasawa
authors.forename: Tsunehiko
authors.initials: T
authors.lastname: Soga
mesh_terms: D000080:Acetals / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000077143:Docetaxel; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D043823:Taxoids; D014407:Tumor Cells, Cultured / Q000187:drug effects*
chemical_list: D000080:Acetals; D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel