The non-steroidal anti-inflammatory drug niflumic acid inhibits Candida albicans growth.
The non-steroidal anti-inflammatory drug niflumic acid was found to inhibit growth of the yeast form of Candida albicans. Niflumic acid inhibited respiratory oxygen uptake and it is hypothesised that this was achieved by cytosolic acidification and block of glycolysis. Inhibitory concentrations are compatible with current practice of topical application.
Baker
Andrew
A
Department of Plant Sciences, University of Cambridge, United Kingdom.
Northrop
Frederick D
FD
Miedema
Hendrik
H
Devine
Gary R
GR
Davies
Julia M
JM
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D003470:Culture Media; D009544:Niflumic Acid / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000935:Antifungal Agents; D003470:Culture Media; D009544:Niflumic Acid