title: [Teratogenic effects of incorporated radionuclides].
abstract: Experimental data on teratogenic effects induced by incorporated alpha, beta and gamma-emitters were analyzed. It was found that the radioactive substances as well as external irradiation induced teratogenic effects. Teratogenesis caused by incorporated radionuclides has some peculiarities compared to the effect caused by fetus exposure to external radiation. These peculiarities are related to the fact of the limited penetration of incorporated radionuclides via placenta barrier so the radiation fetal doses are accumulated within long period of time and radiation dose rates are relatively low. The exposure to incorporated radionuclides does not induce severe developmental defects. Most frequent developmental defects of fetus include its death, general retardation of the development and growth. In such case the earlier pregnancy term was affected by radionuclide the more severe fetal damages occur in fetus because of the gradual increase of absorbed dose even in case of single intake of radionuclide. RBEs of radionuclides if compared to that for external gamma radiation are evaluated as follows: 2-4 (tritium oxide), 20 (241Am), 50 (238Pu) and 3-5 (131I in thyroid).
authors.affiliation: State Research Centre of Russia-Institute of Biophysics, Moscow, 123182 Russia. ibphgen@rcibph.dol.ru
authors.forename: A M
authors.initials: AM
authors.lastname: Liaginskaia
authors.forename: V A
authors.initials: VA
authors.lastname: Osipov
mesh_terms: D000016:Abnormalities, Radiation-Induced / Q000209:etiology; D000818:Animals; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D005720:Gamma Rays; D005865:Gestational Age; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental; D051381:Rats; D013997:Time Factors