Evaluation of REMEDi HS in the diagnosis of dimethoate poisoning.
The authors describe the evaluation of an automated rapid emergency drug profiling system (REMEDi HS), which is designed for clinical toxicology and therapeutic drug monitoring, in a severe case of dimethoate poisoning. Successful qualitative and quantitative determination of dimethoate in diluted serum samples was achieved. The authors found that dimethoate serum concentrations were properly measured with the REMEDi method and well correlated with gas chromatography-mass spectrometry. The results provide evidence that besides screening and rapid estimation of drug concentrations in human fluids, this system is a suitable tool in cases of symptomatic dimethoate poisoning.
Regenthal
Ralf
R
Institute of Clinical Pharmacology, Institute of Forensic Sciences, University of Leipzig, Haertelstrasse 16-18, D-04107 Leipzig, Federal Republic of Germany. regenr@medizin.uni-leipzig.de
Krueger
Mario
M
Trauer
Heiner
H
Boehm
Reinhard
R
Preiss
Rainer
R
D000328:Adult; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004117:Dimethoate / Q000097:blood / Q000506:poisoning*; D016903:Drug Monitoring / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry / Q000295:instrumentation / Q000379:methods; D006801:Humans; D007306:Insecticides / Q000097:blood / Q000506:poisoning*; D008297:Male; D011041:Poisoning / Q000175:diagnosis; D013405:Suicide
D007306:Insecticides; D004117:Dimethoate