title: Translocation of tRNA during protein synthesis.
abstract: Coupled translocation of tRNA and mRNA in the ribosome during protein synthesis is one of the most challenging and intriguing problems in the field of translation. We highlight several key questions regarding the mechanism of translocation, and discuss possible mechanistic models in light of the recent crystal structures of the ribosome and its subunits.
authors.affiliation: Center for Molecular Biology of RNA and Department of Molecular, Cellular and Developmental Biology, Sinsheimer Laboratories, UCSC, Santa Cruz, CA 95064, USA. harry@nuvolari.ucsc.edu
authors.forename: Harry F
authors.initials: HF
authors.lastname: Noller
authors.forename: Marat M
authors.initials: MM
authors.lastname: Yusupov
authors.forename: Gulnara Z
authors.initials: GZ
authors.lastname: Yusupova
authors.forename: Albion
authors.initials: A
authors.lastname: Baucom
authors.forename: J H D
authors.initials: JH
authors.lastname: Cate
mesh_terms: D000818:Animals; D001665:Binding Sites; D001692:Biological Transport; D006801:Humans; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis / Q000502:physiology*; D011487:Protein Conformation; D012343:RNA, Transfer / Q000737:chemistry / Q000502:physiology*; D012270:Ribosomes / Q000737:chemistry / Q000502:physiology
chemical_list: D012343:RNA, Transfer