title: New efficient construction of the ABC core of the taxoids via a sequence of consecutive cobalt(I)-mediated [2 + 2 + 2] and [4 + 2] cyclizations.
abstract: [reaction: see text] A new and efficient sequence of two consecutive cyclizations, a cobalt(I)-mediated [2 + 2 + 2] cyclotrimerization and a Diels-Alder reaction, is proposed to allow the formation of the ABC core of the taxoids in 65% overall yield, starting from an acyclic polyunsaturated precursor.
authors.affiliation: Université Pierre et Marie Curie (Paris 6), Laboratoire de Chimie Organique de Synthèse associé au CNRS, Tour 44-54, 2ème étage, Case 229, 4 place Jussieu 75252, Paris Cedex 05, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Petit
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Chouraqui
authors.forename: Phannarath
authors.initials: P
authors.lastname: Phansavath
authors.forename: Corinne
authors.initials: C
authors.lastname: Aubert
authors.forename: Max
authors.initials: M
authors.lastname: Malacria