title: Immunocytochemical increased evidence of inducible nitric oxide synthase, tumor necrosis factor-alpha, and adrenocorticotropic hormone in human peritumoral lymph nodes.
abstract: In the current study, mesenteric and peritumoral lymph nodes surgically removed from patients with colon-rectum cancer were studied. Morphologic and immunocytochemical investigations demonstrated that mesenteric (control) and peritumoral lymph nodes of a same patient showed the same morphologic structure, but a different immunocytochemical pattern. Indeed, an increased immunoreactivity to anti-inducible nitric oxide synthase, anti-tumor necrosis factor-alpha, and anti-adrenocorticotropic hormone antibodies in the lymphatic tissue of peritumoral lymph nodes compared with mesenteric lymph nodes was observed. These findings suggest that in colon-rectum cancer, the pathologic event induces an increased expression of the molecules involved in the processes of inflammation and carcinogenesis that occurs earlier than the appearance of morphologic modifications.
authors.affiliation: Surgical Clinic and Emergency Surgery, University of Modena and Reggio Emilia, Modena, Italy. rossia@unimo.it
authors.forename: Aldo
authors.initials: A
authors.lastname: Rossi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Landolfo
authors.forename: Davide
authors.initials: D
authors.lastname: Sassi
authors.forename: Antonella
authors.initials: A
authors.lastname: Franchini
authors.forename: Enzo
authors.initials: E
authors.lastname: Ottaviani
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000201:enzymology / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D000324:Adrenocorticotropic Hormone; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II