Task force report: future research needs for the prevention and management of immune-mediated drug hypersensitivity reactions.
Immune-mediated drug hypersensitivity reactions (IDHR) have a significant impact on clinical practice, drug development, and public health. However, research to understand IDHR mechanisms and to develop diagnostic and predictive tests has been limited. To stimulate more research, a task force with representatives from the key stakeholders (research clinicians, regulatory scientists, and immunotoxicologists from the pharmaceutical industry) was assembled to identify critical data gaps and opportunities and to make recommendations on how to overcome some of the barriers to IDHR research and address research needs. It is hoped that this report will act as a springboard for future discussions and progress toward increased funding and development of organizational structures for IDHR research.
Adkinson
N Franklin
NF
Johns Hopkins School of Medicine, Baltimore, Md., USA.
Essayan
David
D
Gruchalla
Rebecca
R
Haggerty
Helen
H
Kawabata
Thomas
T
Sandler
J David
JD
Updyke
Lawrence
L
Shear
Neil H
NH
Wierda
Daniel
D
D015195:Drug Design; D004342:Drug Hypersensitivity / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy*; D064420:Drug-Related Side Effects and Adverse Reactions; D006287:Health Planning Guidelines; D006801:Humans; D020380:Needs Assessment; D012106:Research