title: Cardiovascular risk factors and disease in general practice: results of the Nijmegen Cohort Study.
abstract: The relationship between risk factors and cardiovascular disease (CVD) was determined using data from the Nijmegen Cohort study, an 18-year prospective study. In 1977, cardiovascular risk factors were measured in 7092 Caucasian males and females from six general practices: age, smoking, serum cholesterol, blood pressure, body mass index and a family history of CVD were related to subsequent CVD mortality and morbidity. Most patients had more than one risk factor in particular among men. A significant relationship between risk factors and CVD was demonstrated. In men, a relative risk (RR) of 1.8 was found for both high blood pressure and smokers. A positive family history yielded a RR of 1.8. The risk increased gradually with the number of risk factors; 38% of the group with all risk factors suffered a CVD within 18 years. In women, comparable RRs were found but the low absolute risk of CVD should indicate against the treatment of cardiovascular risk factors.
authors.affiliation: Department of General Practice, University of Nijmegen, The Netherlands.
authors.forename: J C
authors.initials: JC
authors.lastname: Bakx
authors.forename: H J M
authors.initials: HJ
authors.lastname: Van den Hoogen
authors.forename: W J H M
authors.initials: WJ
authors.lastname: Van den Bosch
authors.forename: T
authors.initials: T
authors.lastname: Thien
authors.forename: C
authors.initials: C
authors.lastname: van Weel
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D005194:Family Practice; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012307:Risk Factors; D017678:Sex Distribution
chemical_list: D002784:Cholesterol