N-alkylaminoacids and their derivatives interact with melanocortin receptors.
Thirty four N-alkylaminoacids (Arg, Trp, Nal, Pro, Hyp, L and D) and derivatives were prepared by a process that included reductive alkylation of the amino function. Both solid phase and solution synthesis was used. Title substances displayed binding activity on melanocortin receptors MC(1,3-5) reaching the low micromolar range.
Mutulis
Felikss
F
Department of Pharmaceutical Biosciences, Division of Pharmacology, Uppsala Biomedical Center, PO Box 591, Uppsala University, S-751 24 Uppsala, Sweden.
Mutule
Ilze
I
Wikberg
Jarl E S
JE
D000478:Alkylation; D000596:Amino Acids / Q000378:metabolism*; D001667:Binding, Competitive; D002460:Cell Line; D006801:Humans; D007457:Iodine Radioisotopes; D008956:Models, Chemical; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011485:Protein Binding; D044104:Receptor, Melanocortin, Type 3; D044105:Receptor, Melanocortin, Type 4; D018043:Receptors, Corticotropin / Q000378:metabolism*; D044101:Receptors, Melanocortin
D000596:Amino Acids; D007457:Iodine Radioisotopes; D044104:Receptor, Melanocortin, Type 3; D044105:Receptor, Melanocortin, Type 4; D018043:Receptors, Corticotropin; D044101:Receptors, Melanocortin; C086971:melanocortin 5 receptor