Diethyldithiocarbamate inhibition of galactosamine-induced hepatitis in rats.
Free-radical-mediated oxidant damage can contribute to acute hepatitis. Vitamin E, a classic antioxidant, has been tested as a therapy for rodent acute hepatitis, but the protection achieved has not been complete. This study demonstrated that in rats, sodium diethyldithiocarbamate (DDC), a potent antioxidant, strongly depressed galactosamine-induced hepatitis in terms of serum alanine amino transferase activities and bile acids, though not in terms of serum beta-glucuronidase activities. A potential limitation for DDC use in humans, inhibition of copper metalloenzyme activities, did occur at the DDC dose used here. However, these effects were not severe. Thus, DDC could make a useful short term therapeutic drug for acute hepatitis.
Disilvestro
Robert A
RA
Department of Human Nutrition, The Ohio State University, Columbus, OH 43210-1295, USA. disilvestro.1@osu.edu
Rogers
David L
DL
Lee
Haeyun G
HG
D000208:Acute Disease; D000410:Alanine Transaminase / Q000037:antagonists & inhibitors / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001647:Bile Acids and Salts / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D004050:Ditiocarb / Q000627:therapeutic use*; D005688:Galactosamine / Q000633:toxicity*; D005966:Glucuronidase / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors / Q000097:blood
D000975:Antioxidants; D001647:Bile Acids and Salts; D005688:Galactosamine; D004050:Ditiocarb; D013482:Superoxide Dismutase; D000410:Alanine Transaminase; D005966:Glucuronidase