title: Effect of vessel size on the flow efficiency of the total cavopulmonary connection: in vitro studies.
abstract: The total cavopulmonary connection (TCPC) creates a passive system of blood flow into the pulmonary circulation. We hypothesize that the efficiency differences found in models with superior vena cava-inferior vena cava (SVC-IVC) offsets is dependent on vessel size, with flow efficiency improving with larger size vessels. Two sets of in vitro TCPC models (TCPC-3 and TCPC-15) were constructed corresponding to average vessel diameters of 3- and 15-year-old patients. The model with full SVC-IVC offset was the most efficient in TCPC-3 models. There was no significant difference between geometric arrangements in TCPC-15 models; however, the average efficiencies were significantly higher. Among the models representing vessel sizes of the younger age group, the model with the full-diameter SVC-IVC offset was the most efficient. The models representing vessel sizes of the older age group showed marked improvement in efficiencies throughout without obvious differences between various geometric arrangements. This suggests that geometric considerations in TCPC surgical techniques may be of lower than expected significance over the life span of a patient. More important, after balancing the effects of improved flow efficiency with larger vessels against the effects of chronic volume overload, the trend of performing the Fontan surgery on increasingly younger patients may need to be reconsidered after further studies.
authors.affiliation: University of Colorado Health Science Center, The Children's Hospital, 1056 E. 19th Avenue, B-100 Denver, CO 80218, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: DeGroff
authors.forename: J D
authors.initials: JD
authors.lastname: Carlton
authors.forename: C E
authors.initials: CE
authors.lastname: Weinberg
authors.forename: M C
authors.initials: MC
authors.lastname: Ellison
authors.forename: R
authors.initials: R
authors.lastname: Shandas
authors.forename: L
authors.initials: L
authors.lastname: Valdes-Cruz
mesh_terms: D000293:Adolescent; D000714:Anastomosis, Surgical; D002675:Child, Preschool; D018729:Fontan Procedure; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D012039:Regional Blood Flow; D016896:Treatment Outcome; D014682:Vena Cava, Inferior / Q000473:pathology / Q000503:physiopathology*; D014683:Vena Cava, Superior / Q000473:pathology / Q000503:physiopathology*