Familial mediterranean fever and Behçet's disease--are they associated?
OBJECTIVE
To test whether the coexistence of familial Mediterranean fever (FMF) and Behçet's disease (BD) is more frequent than expected and whether each disease affects the severity of the other.


METHODS
We screened 353 charts of patients with FMF to detect individuals with concomitant BD. Of these, 152 patients with FMF over the age of 18 years were also interviewed and examined specifically. We also studied 53 patients with BD, looking for FMF and for their MEFV mutations. We compared BD patients with MEFV mutations to those without them.


RESULTS
None of 353 patients with FMF was found to have concomitant BD. Sixteen patients with BD bore MEFV mutations, 2 of whom were symptomatic homozygotes and had concomitant FMF. No patient with BD with a single MEFV mutation had FMF. Both BD groups (with or without MEFV mutations) were similar in their clinical manifestations and disease course.


CONCLUSIONS
BD and FMF are 2 separate entities that have a mild trend toward a higher than expected association. However, there was no mutual effect of FMF on BD or vice versa.
Ben-Chetrit
Eldad
E
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel. eldad@hadassah.org.il
Cohen
Ronit
R
Chajek-Shaul
Tova
T
D000328:Adult; D000368:Aged; D018912:Arabs / Q000235:genetics; D001528:Behcet Syndrome / Q000453:epidemiology* / Q000235:genetics*; D003598:Cytoskeletal Proteins; D010505:Familial Mediterranean Fever / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006579:Heterozygote; D006801:Humans; D007585:Jews / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000235:genetics*; D000071198:Pyrin
D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D011506:Proteins; D000071198:Pyrin