title: Immunotherapy of cancer with alloreactive lymphocytes.
abstract: Immunotherapy of cancer with alloreactive lymphocytes is the mainstay of treatment, especially in haematological malignant disease. With donor lymphocyte infusion for immunotherapy, it is essential to induce host-versus-graft tolerance to ensure that the donor lymphocytes are accepted. Engraftment of haemopoietic cells of donor origin can be accomplished with reduced-intensity conditioning. Reducing transplant-related mortality by simplifing the stem-cell transplant procedure with a reduced-intensity regimen, particularly non-myeloablative conditioning, may have great potential for the treatment of malignant and non-malignant disorders.
authors.affiliation: Department of Bone Marrow Transplantation & Cancer Immunotherapy, Hadassah University Hospital, Ein Karem Jerusalem, Israel. slavin@cc.huji.ac.il
authors.forename: S
authors.initials: S
authors.lastname: Slavin
mesh_terms: D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology*; D009369:Neoplasms / Q000628:therapy*