Cardioacceleratory effects of Manduca sexta allatotropin in the true armyworm moth, Pseudaletia unipuncta.
Manduca sexta allatotropin (Manse-AT), a peptide originally isolated on the basis of its ability to stimulate juvenile hormone (JH) biosynthesis in the tobacco hornworm, is a potent in vitro stimulator of the corpora allata (CA) in Pseudaletia unipuncta (Lepidoptera: Noctuidae). At 10(-6)M, Manse-AT stimulated in vitro rates of JH biosynthesis by CA of day 0 and 6 adult females 15- and 10-fold respectively. Both Manse-AT and serotonin were also shown to be dose-dependent stimulators of heart rate in day 0, 3 and 6 adult males and females. Furthermore, analysis suggests that there are differences in both resting and Manse-AT-stimulated heart rates depending on age and rearing conditions.
Koladich
P M
PM
Department of Zoology, University of Toronto, M5S 3G5, Toronto, ON, Canada.
Cusson
M
M
Bendena
W G
WG
Tobe
S S
SS
McNeil
J N
JN
D000818:Animals; D003335:Corpora Allata / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D007301:Insect Hormones / Q000494:pharmacology*; D007605:Juvenile Hormones / Q000096:biosynthesis; D008297:Male; D018402:Manduca / Q000737:chemistry*; D009036:Moths / Q000033:anatomy & histology / Q000378:metabolism*; D009479:Neuropeptides / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology
D007301:Insect Hormones; D007605:Juvenile Hormones; D009479:Neuropeptides; D012701:Serotonin; C050669:allatotropin