title: Mycetoma caused by Fusarium solani with osteolytic lesions on the hand: case report.
abstract: Eumycetoma is a mycotic disease caused by saprophytic soil fungi that are usually inoculated through minor injuries. A case of mycetoma in a Brazilian farmer aged 71 years is reported. This patient presented erythema and edema on the dorsal surface of the left hand with multiple crusted and cicatricial lesions. No macroscopic grains were observed. The histopathological findings showed grains consisted of numerous hyphae which stained well with Gomori-Grocott method. This material obtained by cutaneous biopsy was submitted to culture on Sabouraud's medium and the colonies were identified as Fusarium solani. The radiological studies revealed bone osteolytic lesions and the ultrasound showed pseudocysts and fistulae at the site of this infection. The patient was treated with oral ketoconazole with a good clinical response.
authors.affiliation: Department of Dermatology, Federal University of São Paulo (UNIFESP-EPM), São Paulo, Brazil. jane.derm@epm.br
authors.forename: Jane
authors.initials: J
authors.lastname: Tomimori-Yamashita
authors.forename: Marília M
authors.initials: MM
authors.lastname: Ogawa
authors.forename: Sérgio H
authors.initials: SH
authors.lastname: Hirata
authors.forename: Olga
authors.initials: O
authors.lastname: Fischman
authors.forename: Nílceo S
authors.initials: NS
authors.lastname: Michalany
authors.forename: Hélio Kiitiro
authors.initials: HK
authors.lastname: Yamashita
authors.forename: Mauricio
authors.initials: M
authors.lastname: Alchorne
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D005670:Fusarium / Q000302:isolation & purification*; D006225:Hand / Q000000981:diagnostic imaging / Q000473:pathology; D006229:Hand Dermatoses / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D008297:Male; D008663:Metacarpus / Q000000981:diagnostic imaging / Q000473:pathology; D009181:Mycoses / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000382:microbiology*; D011859:Radiography
chemical_list: D000935:Antifungal Agents; D007654:Ketoconazole