Helicobacter pylori and gastrointestinal tract adenocarcinomas.
Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in the stomach, only a small fraction of colonized individuals develop this common malignancy. H. pylori strain and host genotypes probably influence the risk of carcinogenesis by differentially affecting host inflammatory responses and epithelial-cell physiology. Understanding the host-microbial interactions that lead to neoplasia will improve cancer-targeted therapeutics and diagnostics, and provide mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.
Peek
Richard M
RM
Division of Gastroenterology, Vanderbilt University School of Medicine, Medical Center North, Nashville, Tennessee 37232-2279, USA. richard.peek@mcmail.vanderbilt.edu
Blaser
Martin J
MJ
D000230:Adenocarcinoma / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology / Q000517:prevention & control; D000293:Adolescent; D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017209:Apoptosis; D001284:Atrophy; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000235:genetics; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000382:microbiology; D005764:Gastroesophageal Reflux / Q000453:epidemiology; D005770:Gastrointestinal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology / Q000517:prevention & control; D020022:Genetic Predisposition to Disease; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D016480:Helicobacter pylori / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D015994:Incidence; D008297:Male; D008679:Metaplasia; D051379:Mice; D008875:Middle Aged; D011110:Polymorphism, Genetic; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D016207:Cytokines