title: In vitro and in vivo activities of a novel cephalosporin, BMS-247243, against organisms other than staphylococci.
abstract: BMS-247243, a novel cephalosporin inhibitory for methicillin-resistant staphylococci, primarily has activity against gram-positive bacteria. The activities of BMS-247243, cefotaxime, and ceftriaxone against streptococci and Streptococcus pneumoniae were similar. BMS-247243 inhibits Enterococcus faecalis but not Enterococcus faecium. BMS-247243 also inhibits many inherently vancomycin-resistant species (Leuconstoc, Lactobacillus, Pediococcus) and anaerobic gram-positive bacteria.
authors.affiliation: Department of Microbiology, Bristol-Myers Squibb Co., Wallingford, Connecticut 06492, USA.
authors.forename: Junius
authors.initials: J
authors.lastname: Clark
authors.forename: Joan C
authors.initials: JC
authors.lastname: Fung-Tomc
authors.forename: Beatrice
authors.initials: B
authors.lastname: Minassian
authors.forename: Yuan-Hwang
authors.initials: YH
authors.lastname: Tsai
authors.forename: Hyekyung
authors.initials: H
authors.lastname: Yang
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Huczko
authors.forename: Benjamin
authors.initials: B
authors.lastname: Kolek
authors.forename: Susan
authors.initials: S
authors.lastname: Chaniewski
authors.forename: Cheryl
authors.initials: C
authors.lastname: Ferraro
authors.forename: Rebecca
authors.initials: R
authors.lastname: Drain
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Gradelski
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Bonner
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects; D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005260:Female; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006801:Humans; D007165:Immunosuppression Therapy; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D009025:Morpholines / Q000494:pharmacology*; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000382:microbiology; D011725:Pyridines / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D002511:Cephalosporins; D009025:Morpholines; D011725:Pyridines; C452864:BMS-247243