Expression and regulation of thioredoxin reductases and other selenoproteins in bone.
The expression of thioredoxin reductases and other selenoproteins in cells of the bone microenvironment may represent an important means of regulation of bone resorption and remodeling in health and disease. Selenoproteins and their substrates may influence intracellular and extracellular redox-dependent signaling, transcription factor activity, posttranslational modification of proteins, and general or compartmentalized scavenging from ROIs. However, the evaluation of their biological role in bone and their potential in terms of therapeutic approaches is just beginning.
Jakob
Franz
F
Orthopedic Department, University of Wuerzburg, D-97074 Wuerzburg, Germany.
Becker
Katja
K
Paar
Ellen
E
Ebert-Duemig
Regina
R
Schütze
Norbert
N
D001851:Bone Diseases, Metabolic / Q000188:drug therapy / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D002117:Calcitriol / Q000494:pharmacology; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008722:Methods; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism; D010084:Oxidation-Reduction; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D017382:Reactive Oxygen Species / Q000378:metabolism; D012643:Selenium / Q000172:deficiency / Q000627:therapeutic use; D051140:Selenoproteins; D013880:Thioredoxin-Disulfide Reductase / Q000032:analysis / Q000235:genetics / Q000378:metabolism*
D011506:Proteins; D012333:RNA, Messenger; D017382:Reactive Oxygen Species; D051140:Selenoproteins; D005979:Glutathione Peroxidase; D013880:Thioredoxin-Disulfide Reductase; D002117:Calcitriol; D012643:Selenium