Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats.
We examined the influence of imipramine and lithium on wet-dog shakes induced by the (+/-)-DOI, 5-HT2A receptor agonist in adrenocorticotropic hormone (ACTH)-treated rats. The administration of imipramine for 14 days decreased the (+/-)-DOI-induced wet-dog shakes response; chronic administration of lithium for 14 days, however, had no effect. Chronic ACTH (100 microg/rat sc) treatment increased the wet-dog shake response induced by (+/-)-DOI. This effect of ACTH for 14 days, increasing the (+/-)-DOI-induced wet-dog shakes, was not inhibited by a 14-day administration of imipramine. Chronic coadministration of imipramine and lithium, lasting 14 days, decreased the wet-dog shakes response induced by (+/-)-DOI in rats treated with ACTH for 14 days. These findings indicate that lithium inhibits the hyperfunction of the 5-HT2A receptor in rats treated with ACTH when coadministered with imipramine.
Kitamura
Yoshihisa
Y
Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1, Shikata-cho, Okayama, 700-8558 Japan.
Araki
Hiroaki
H
Suemaru
Katsuya
K
Gomita
Yutaka
Y
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage*; D000818:Animals; D007099:Imipramine / Q000008:administration & dosage*; D008094:Lithium / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects* / Q000502:physiology; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000502:physiology*
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D000324:Adrenocorticotropic Hormone; D008094:Lithium; D007099:Imipramine