title: Extensive cerebral venous thrombosis associated with moderate hyperhomocyst(e)inemia and successfully treated with thrombolysis.
abstract: Cerebral venous thrombosis (CVT) is a relatively rare condition caused by multiple etiologies, usually secondary to hypercoagulable states. The optimal treatment is controversial, especially in the presence of hemorrhagic infarcts. We describe an unusual patient with extensive CVT associated with moderate hyperhomocyst(e)inemia who was aggressively treated with chemical and mechanical thrombolysis with an excellent outcome.
authors.affiliation: Department of Neurology, Lahey Clinic, Burlington, Mass, USA. claudia.j.chaves@lahey.org
authors.forename: Claudia
authors.initials: C
authors.lastname: Chaves
authors.forename: Barbara
authors.initials: B
authors.lastname: Voetsch
authors.forename: Joseph
authors.initials: J
authors.lastname: Loscalzo
authors.forename: Louis
authors.initials: L
authors.lastname: Caplan
authors.forename: Ram
authors.initials: R
authors.lastname: Chavali
mesh_terms: D000328:Adult; D002550:Cerebral Veins / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications* / Q000188:drug therapy*; D020767:Intracranial Thrombosis / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D012720:Severity of Illness Index; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D010959:Tissue Plasminogen Activator