title: Intracranial oscillations of cerebrospinal fluid and blood flows: analysis with magnetic resonance imaging.
abstract: OBJECTIVE
  To detect oscillations of the cerebrospinal fluid (CSF) flow related to the heartbeat and frequencies lower than 0.6 Hz and to compare these oscillations of CSF and blood flow in cerebral vessels by using echo planar imaging in real time mode. The existence of such waves has been well known but has not yet been shown by MRI.
  
  
  METHODS
  In a slice perpendicular to the aqueduct, CSF flow as well as CBF, could be determined in sagittal sinus, basilar artery, and capillary vessels. After Fourier analysis, four frequency bands were assigned.
  
  
  RESULTS
  In the very high-frequency (heart rate) range, the integrals under the CSF curves were more closely related to arterial CBF than to changes in the sinus. Also, in the high-frequency (respiration rate), low-frequency (0.05-0.15 Hz), and very-low-frequency (0.008-0.05 Hz) ranges, the integrals under the CSF curves corresponded with arterial and capillary CBF.
  
  
  CONCLUSIONS
  Slow and fast oscillations in CSF flow are detectable in healthy persons with a proportional allotment to arterial and capillary CBF.
authors.affiliation: Section of Experimental MR of the CNS, Department of Neuroradiology, University of Tuebingen, Germany. CStrik@AOL.com
authors.forename: Claudia
authors.initials: C
authors.lastname: Strik
authors.forename: Uwe
authors.initials: U
authors.lastname: Klose
authors.forename: Michael
authors.initials: M
authors.lastname: Erb
authors.forename: Herwig
authors.initials: H
authors.lastname: Strik
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Grodd
mesh_terms: D000293:Adolescent; D000328:Adult; D001683:Biological Clocks; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011673:Pulsatile Flow / Q000502:physiology; D012039:Regional Blood Flow