title: Molecular physiology of osmoregulation in eels and other teleosts: the role of transporter isoforms and gene duplication.
abstract: This review focuses on recent developments in the molecular biology of ion and water transporter genes in fish and the potential role of their products in osmoregulation in both freshwater and seawater environments. In particular details of isoforms of various ATPases, co-transporters, exchangers and ion channels in the eel as well as other teleost species are described. Many of the teleost transporter isoforms discovered so far, appear to occur as twin or duplicate copies compared to their homologous counterparts in higher vertebrates, although these duplicate isoforms often have distinct tissue-specific and developmental stage-dependent expression patterns. The possible meaning of this information will be examined in relation to the fish genome duplication debate.
authors.affiliation: School of Biology, University of St Andrews, Fife, UK. cpc@st-and.ac.uk
authors.forename: C P
authors.initials: CP
authors.lastname: Cutler
authors.forename: G
authors.initials: G
authors.lastname: Cramb
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D004524:Eels / Q000502:physiology*; D005399:Fishes / Q000502:physiology*; D020440:Gene Duplication; D008969:Molecular Sequence Data; D009994:Osmolar Concentration; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D017386:Sequence Homology, Amino Acid
chemical_list: D002352:Carrier Proteins; D020033:Protein Isoforms