[Liberation of potential local anesthetics from colloidal dispersions].
Evaluation of pharmaceutical availability of drugs from topical preparations is usually aimed to evaluate the capability of the dosage form to release the drug for its therapeutic action. Permeation cells have been used for this purpose, employing solid membranes including cellophane. Within a study of phenylcarbamic acid derivatives with local anaesthetic effect, the present paper evaluates the dosage form for topical administration containing potential drug XIX M, the chemical name N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl]-morpholinium chloride and potential drug XXII B, the chemical name N-[2-(2-octyloxyphenylcarbamoyloxy)-ethyl]-dimethylammonium chloride. The selected auxiliary substance in the formulation of the dosage form was a cellulose derivative--methylcellulose in increasing concentrations from 0.5 to 1.5%. On the basis of the obtained results it can be stated that the examined polymer methylcellulose with increasing concentration decelerated the release of both potential drugs approximately in the same way and that it can be used in practice to prolong the local anaesthetic effect.
Vitková
Z
Z
Katedra galenickej farmácie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Skarbalová
M
M
Klasovitá
J
J
Rak
J
J
D000779:Anesthetics, Local / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D003102:Colloids; D003956:Dialysis; D004304:Dosage Forms; D008747:Methylcellulose; D014677:Pharmaceutical Vehicles; D010671:Phenylurea Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000779:Anesthetics, Local; D003102:Colloids; D004304:Dosage Forms; D014677:Pharmaceutical Vehicles; D010671:Phenylurea Compounds; D008747:Methylcellulose