title: [Endovascular gamma-irradiation for prevention or restenosis after angioplasty of femoropopliteal de-novo-stenoses-long-term results of a feasibility study].
abstract: OBJECTIVE
  To evaluate the performance and efficacy of endovascular irradiation after percutaneous transluminal angioplasty (PTA) of de-novo femoropopliteal stenoses in a pilot study.
  
  
  METHODS
  6 patients received non-centered endovascular irradiation (12 Gray at surface of the vessel wall) immediately after angioplasty of de-novo femoropopliteal stenosis, 1 patient was given centered endovascular irradiation using 192-iridium (12 Gray at surface of the vessel wall) Centered irradiation was considered for two other patients. Duplex sonographies and interviews were performed the day before and after PTA and after 1, 3, 6, 9, 12, 18, 24 months up to 4 years. Intraarterial angiography was performed in symptomatic patients.
  
  
  RESULTS
  Non-centered endovascular irradiation was possible in all patients without problems or complications. Centered irradiation was not possible in two patients with the cross-over approach. One thromboembolic complication occurred during centered irradiation. Both restenosis and new stenosis at the edge of irradiated distance occurred in 1/7 patients. No other side effects were observed during follow-up.
  
  
  CONCLUSIONS
  In our pilot study endovascular irradiation after angioplasty of de-novo femoropopliteal stenosis was possible with low rates of complications and restenosis and taking vessel anatomy into account.
authors.affiliation: Institut und Poliklinik für Radiologische Diagnostik, Universität zu Köln, Germany. Karsten.Krueger@uni-koeln.de
authors.forename: K
authors.initials: K
authors.lastname: Krüger
authors.forename: M
authors.initials: M
authors.lastname: Bendel
authors.forename: M
authors.initials: M
authors.lastname: Zähringer
authors.forename: R
authors.initials: R
authors.lastname: Bongartz
authors.forename: M
authors.initials: M
authors.lastname: Nolte
authors.forename: O
authors.initials: O
authors.lastname: Schulte
authors.forename: K
authors.initials: K
authors.lastname: Lackner
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography; D000800:Angioplasty, Balloon / Q000295:instrumentation*; D001918:Brachytherapy / Q000295:instrumentation*; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000601:surgery*; D006083:Graft Occlusion, Vascular / Q000532:radiotherapy*; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D007511:Ischemia / Q000000981:diagnostic imaging / Q000601:surgery*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011150:Popliteal Artery / Q000000981:diagnostic imaging / Q000601:surgery*; D011879:Radiotherapy Dosage
chemical_list: D007496:Iridium Radioisotopes