Cyclooxygenase-2 overexpression, using an integrin-targeted gene delivery system (the LID vector), inhibits fibroblast proliferation in vitro and leads to increased prostaglandin E(2) in the lung.
Jenkins
Gisli
G
Centre for Respiratory Research, Royal Free and University College Medical School, Rayne Institute, London, UK. gjloffice@ucl.ac.uk
Hart
Stephen L
SL
Hodges
Rebecca J
RJ
Meng
Qin-Hai
QH
Kinnon
Christine
C
Laurent
Geoffrey J
GJ
McAnulty
Robin J
RJ
D000818:Animals; D002455:Cell Division; D051546:Cyclooxygenase 2; D015232:Dinoprostone / Q000096:biosynthesis*; D005347:Fibroblasts / Q000473:pathology*; D018390:Gene Targeting; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D066298:In Vitro Techniques; D016023:Integrins / Q000235:genetics*; D007527:Isoenzymes / Q000096:biosynthesis / Q000235:genetics*; D008156:Luciferases / Q000235:genetics; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008565:Membrane Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D010714:Phosphatidylethanolamines / Q000235:genetics; D010957:Plasmids / Q000235:genetics; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis / Q000235:genetics*; D011658:Pulmonary Fibrosis / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D014162:Transfection
D016023:Integrins; D007527:Isoenzymes; D008565:Membrane Proteins; D010714:Phosphatidylethanolamines; C020888:1,2-dielaidoylphosphatidylethanolamine; D008156:Luciferases; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D015232:Dinoprostone