Assessing TP53 status in human tumours to evaluate clinical outcome.
TP53 is probably the most extensively studied tumour-suppressor gene, and patients with TP53 mutations are known to have a poor outcome. However, inconsistencies in the analysis of TP53 status, and failure to realize that different mutations behave in different ways, prevent us from effectively applying our vast knowledge of this protein in clinical practice. What simple steps can be taken to ensure that patients benefit from our understanding of TP53?
Soussi
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T
Institut Curie, Université P. & M. Curie, Laboratoire de Génotoxicologie des Tumeurs, Paris, France. thierry.soussi@curie.fr
Béroud
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C
D019943:Amino Acid Substitution; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics / Q000401:mortality; D019656:Loss of Heterozygosity; D008565:Membrane Proteins; D009154:Mutation; D020125:Mutation, Missense; D009369:Neoplasms / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology; D010750:Phosphoproteins / Q000235:genetics / Q000502:physiology; D017354:Point Mutation; D011110:Polymorphism, Genetic; D011379:Prognosis; D022821:RNA Splice Sites / Q000235:genetics; D013329:Structure-Activity Relationship; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors; D015533:Transcriptional Activation; D016896:Treatment Outcome; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000172:deficiency / Q000235:genetics; D025521:Tumor Suppressor Proteins
C081876:CKAP4 protein, human; D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; D022821:RNA Splice Sites; C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins