title: Aggressive therapy of congestive heart failure and associated chronic renal failure with medications and correction of anemia stops or slows the progression of both diseases.
abstract: The prevalence of congestive heart failure (CHF) is increasing rapidly in the community. We and others have shown that the prevalence and severity of both anemia and chronic renal failure (CRF) increase steadily with increasing severity of CHF. We have also shown that CHF patients may be resistant to standard drug therapy for CHF as long as the associated anemia is not corrected, and that correction of the anemia with subcutaneous erythropoietin and intravenous iron sucrose (Venofer: Vifor International, St. Gallen, Switzerland) may improve both the CHF and CRF and markedly reduce hospitalizations without causing side effects. We report here our experience with correcting anemia in this manner in 126 cases of anemic-resistant CHF patients. As in our previous studies, correction of the anemia improved both CHF and CRF, and reduced hospitalizations. Our studies suggest that correction of even mild anemia in CHF may be an important addition to the treatment of patients with the combination of CHF and CRF.
authors.affiliation: Department of Nephrology, Tel Aviv Medical Center, Israel. donald@netvision.net.il
authors.forename: D S
authors.initials: DS
authors.lastname: Silverberg
authors.forename: D
authors.initials: D
authors.lastname: Wexler
authors.forename: M
authors.initials: M
authors.lastname: Blum
authors.forename: D
authors.initials: D
authors.lastname: Sheps
authors.forename: D
authors.initials: D
authors.lastname: Schwartz
authors.forename: T
authors.initials: T
authors.lastname: Yachnin
authors.forename: R
authors.initials: R
authors.lastname: Baruch
authors.forename: J
authors.initials: J
authors.lastname: Tchebiner
authors.forename: A
authors.initials: A
authors.lastname: Zubkov
authors.forename: M
authors.initials: M
authors.lastname: Shaked
authors.forename: S
authors.initials: S
authors.lastname: Steinbruch
authors.forename: G
authors.initials: G
authors.lastname: Keren
authors.forename: A
authors.initials: A
authors.lastname: Iaina
mesh_terms: D000368:Aged; D000740:Anemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D018450:Disease Progression; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000008:administration & dosage; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage; D000077605:Ferric Oxide, Saccharated; D005919:Glomerular Filtration Rate; D005937:Glucaric Acid; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D011994:Recombinant Proteins; D013318:Stroke Volume; D013395:Sucrose / Q000008:administration & dosage
chemical_list: D005290:Ferric Compounds; D011994:Recombinant Proteins; D004921:Erythropoietin; D013395:Sucrose; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid