title: Antimicrobial activity of 5-arylidene aromatic derivatives of hydantoin. Part 2.
abstract: Various 5-chloroarylidene-2-amino substituted derivatives of imidazoline-4-one were synthesized and evaluated for their activity in vitro against Mycobacterium tuberculosis and other type strains of bacteria and fungi. 2-Chloro- and 2,4-dichlorobenzylidene substituted hydantoins exhibited antimycobacterial effect. The most potent compounds 3i, 3j, 3o, 3q and 3s were classified for further tests. The antimitotic effect of the investigated hydantoins was also examined.
authors.affiliation: Department of Chemical Technology of Drugs, Jagiellonian University Medical College, Kraków, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Szymańska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kieć-Kononowicz
authors.forename: Anna
authors.initials: A
authors.lastname: Białecka
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kasprowicz
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006827:Hydantoins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D006827:Hydantoins