Synthesis and preliminary biological assessments of RGD bearing biocompatible telomers.
Work reported herein deals with the synthesis and preliminary biological assessments of a new class of biocompatible telomeric carriers bearing peptidic RGDSK sequences as tumor cell targeting and tyrosine moieties labelled with 125I as in vivo probe. The radioactivity levels obtained in several tissues, after the intravenous injections of these telomers in mice bearing grafted B16 syngenic melanoma showed that the addition of a RGD residue to a telomeric structure confers it an increased affinity for the highly vascularized zone surrounding the tumor.
Jasseron
Sylvain
S
Laboratoire de Chimie Bioorganique et des Systèmes Moléculaires Vectoriels, Faculté des Sciences, 33, rue Louis Pasteur, 84000 Avignon, France.
Contino-Pépin
Christiane
C
Maurizis
Jean Claude
JC
Rapp
Maryse
M
Pucci
Bernard
B
D000107:Acetylation; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers; D007457:Iodine Radioisotopes; D008297:Male; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging*; D051379:Mice; D008810:Mice, Inbred C57BL; D009842:Oligopeptides / Q000008:administration & dosage / Q000138:chemical synthesis*; D011877:Radionuclide Imaging; D016615:Telomere / Q000737:chemistry*; D014018:Tissue Distribution
D001672:Biocompatible Materials; D004337:Drug Carriers; D007457:Iodine Radioisotopes; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid