title: Expression of the helix-loop-helix gene id3 in the zebrafish embryo.
abstract: Proteins of the Extramacrochaetae and Id subfamily of Helix-Loop-Helix (HLH) proteins are negative regulators of bHLH transcription factors. We cloned a cDNA from zebrafish which encodes a member of the id3 subfamily. High levels of transcripts accumulated in the germ ring and in the embryonic shield. Towards the end of gastrulation, Id3 was highly expressed in the anterior prechordal plate and hypoblast. At later stages, id3 expression was turned on and off in a large variety of tissues within short periods of time. These include the lateral mesoderm, the cornea, the lens, the brain, the neural crest, the retina and the fins.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, BP 163, F-67404 Illkirch Cedex, C.U. de Strasbourg, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Dickmeis
authors.forename: Sepand
authors.initials: S
authors.lastname: Rastegar
authors.forename: Chen Sok
authors.initials: CS
authors.lastname: Lam
authors.forename: Pia
authors.initials: P
authors.lastname: Aanstad
authors.forename: Matthew
authors.initials: M
authors.lastname: Clark
authors.forename: Nadine
authors.initials: N
authors.lastname: Fischer
authors.forename: Frédéric
authors.initials: F
authors.lastname: Rosa
authors.forename: Vladimir
authors.initials: V
authors.lastname: Korzh
authors.forename: Uwe
authors.initials: U
authors.lastname: Strähle
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D018076:DNA, Complementary / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D004625:Embryo, Nonmammalian / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D018257:Helix-Loop-Helix Motifs; D007150:Immunohistochemistry; D051796:Inhibitor of Differentiation Proteins; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D010802:Phylogeny; D012333:RNA, Messenger / Q000378:metabolism; D012160:Retina / Q000196:embryology; D017386:Sequence Homology, Amino Acid; D013997:Time Factors; D014018:Tissue Distribution; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics; D015027:Zebrafish
chemical_list: D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D051796:Inhibitor of Differentiation Proteins; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; C075640:ID3 protein, human