NK T cells are a source of early interleukin-4 following infection with third-stage larvae of the filarial nematode Brugia pahangi.
Infection of C57BL/6 mice with the third-stage larvae of Brugia pahangi results in a rapid expansion of NK1.1(+) T cells in the spleen and draining lymph nodes. NK T cells produced interleukin-4 in the spleen within 24 h of infection, and these cells were CD4(-).
Balmer
Paul
P
Department of Veterinary Parasitology, University of Glasgow, Glasgow G61 1QH, Scotland.
Devaney
Eileen
E
D000818:Animals; D017179:Brugia pahangi; D015704:CD4 Antigens / Q000032:analysis; D005368:Filariasis / Q000276:immunology*; D015847:Interleukin-4 / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000276:immunology*; D007814:Larva; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D015704:CD4 Antigens; D015847:Interleukin-4