Medical treatment of osteoporosis--increasing options.
BACKGROUND
Many drugs are now available for the prevention and treatment of osteoporosis. They have differing levels of evidence of efficacy and each may be used according to clinical indications.


METHODS
A Medline search of clinical drug trials using various therapeutic agents used for osteoporosis was carried out.


RESULTS
Several randomised controlled trials have been carried out using many agents. The agents with the best data to date with regards to the prevention of spine as well as hip fractures in patients with prevalent fractures belong to alendronate and risedronate. Parathyroid hormone has been shown in one trial to reduce the risk of non-vertebral fractures. For reduction of spine fractures, in addition to the above two bisphosphonates, many agents, in particular raloxifene, have been shown to be clearly beneficial. Weaker data exist for hormone replacement, calcitonin, cyclical etidronate and the vitamin D analogues calcitriol and alfacalcidol.


CONCLUSIONS
There are many therapeutic agents shown to be clearly effective in the treatment of osteoporosis.
Leong
K H
KH
Gleneagles Medical Center, 6 Napier Road, #04-18, Singapore 258499.
D000368:Aged; D002116:Calcitonin / Q000008:administration & dosage*; D017610:Calcium Compounds / Q000008:administration & dosage; D019587:Dietary Supplements; D004164:Diphosphonates / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index; D016103:Spinal Fractures / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage
D017610:Calcium Compounds; D004164:Diphosphonates; D014807:Vitamin D; D002116:Calcitonin