title: Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication.
abstract: The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.
authors.affiliation: Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Allen
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Mortara
authors.forename: Bianca R
authors.initials: BR
authors.lastname: Mothé
authors.forename: Max
authors.initials: M
authors.lastname: Liebl
authors.forename: Peicheng
authors.initials: P
authors.lastname: Jing
authors.forename: Briana
authors.initials: B
authors.lastname: Calore
authors.forename: Marian
authors.initials: M
authors.lastname: Piekarczyk
authors.forename: Richard
authors.initials: R
authors.lastname: Ruddersdorf
authors.forename: David H
authors.initials: DH
authors.lastname: O'Connor
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: Chenxi
authors.initials: C
authors.lastname: Wang
authors.forename: David B
authors.initials: DB
authors.lastname: Allison
authors.forename: John D
authors.initials: JD
authors.lastname: Altman
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sette
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Desrosiers
authors.forename: Gerd
authors.initials: G
authors.lastname: Sutter
authors.forename: David I
authors.initials: DI
authors.lastname: Watkins
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D015658:HIV Infections / Q000517:prevention & control; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D008251:Macaca; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014611:Vaccination; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology; D014616:Vaccinia virus / Q000235:genetics; D019562:Viral Load; D014779:Virus Replication
chemical_list: D016915:AIDS Vaccines; D019444:Vaccines, DNA; C421254:human immunodeficiency virus type 1 Tat vaccine