title: Liquid ventilation with perflubron in the treatment of rats with pneumococcal pneumonia.
abstract: OBJECTIVE
  To determine the efficacy of liquid ventilation using a medical-grade perfluorocarbon (perflubron) combined with parenteral or intratracheal antibiotics in a rat model of pneumonia.
  
  
  METHODS
  Prospective, laboratory investigation.
  
  
  METHODS
  Experimental laboratory in a university medical center.
  
  
  METHODS
  Wistar rats (n = 112).
  
  
  METHODS
  One day after intratracheal inoculation with Streptococcus pneumoniae, rats received one of five experimental treatments or no treatment (control): modified liquid ventilation (MLV), intramuscular ampicillin, MLV plus intramuscular ampicillin, MLV with intratracheal ampicillin, or MLV plus ampicillin PulmoSpheres.
  
  
  RESULTS
  Animals receiving MLV plus intramuscular ampicillin, MLV with intratracheal ampicillin, or MLV plus ampicillin PulmoSpheres had significantly improved 10-day survival rates (85%, 72%, and 72%, respectively) compared with all other groups (0% to 25%).
  
  
  CONCLUSIONS
  MLV in combination with either intramuscular, intratracheal, or PulmoSpheres ampicillin improved survival as compared with MLV alone or the same dose of antibiotics delivered intramuscularly.
authors.affiliation: Department of Physiology, University of Massachusetts Medical Center, Worcester, MA 01655, USA. dicksone@ummhc.org
authors.forename: Eric W
authors.initials: EW
authors.lastname: Dickson
authors.forename: Stephen O
authors.initials: SO
authors.lastname: Heard
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Tarara
authors.forename: Jeffry G
authors.initials: JG
authors.lastname: Weers
authors.forename: Angela B
authors.initials: AB
authors.lastname: Brueggemann
authors.forename: Gary V
authors.initials: GV
authors.lastname: Doern
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005466:Fluorocarbons / Q000008:administration & dosage*; D006842:Hydrocarbons, Brominated; D007263:Infusions, Parenteral; D021061:Liquid Ventilation; D008297:Male; D011018:Pneumonia, Pneumococcal / Q000401:mortality / Q000628:therapy*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D016019:Survival Analysis
chemical_list: D000900:Anti-Bacterial Agents; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C003072:perflubron