title: Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains.
abstract: We identified a new type of staphylococcal cassette chromosome mec (SCCmec) from two community-acquired methicillin-resistant Staphylococcus aureus (MRSA) strains. The novel element, designated type IV SCCmec, had a unique combination of the class B mec gene complex and the type 2 ccr gene complex and was much smaller in size (21 to 24 kb) than previously identified SCCmec elements of hospital-acquired MRSA. Consistent with the strains' susceptibilities to various non-beta-lactam antibiotics, the type IV SCCmec was devoid of any antibiotic resistance genes other than the mecA gene.
authors.affiliation: Department of Bacteriology, Juntendo University, Tokyo, Japan.
authors.forename: Xiao Xue
authors.initials: XX
authors.lastname: Ma
authors.forename: Teruyo
authors.initials: T
authors.lastname: Ito
authors.forename: Chuntima
authors.initials: C
authors.lastname: Tiensasitorn
authors.forename: Mantana
authors.initials: M
authors.lastname: Jamklang
authors.forename: Piriyaporn
authors.initials: P
authors.lastname: Chongtrakool
authors.forename: Susan
authors.initials: S
authors.lastname: Boyle-Vavra
authors.forename: Robert S
authors.initials: RS
authors.lastname: Daum
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hiramatsu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D017714:Community-Acquired Infections / Q000382:microbiology*; D004269:DNA, Bacterial / Q000235:genetics; D016106:Methicillin Resistance / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial