title: Intrinsic firing dynamics of vestibular nucleus neurons.
abstract: Individual brainstem neurons involved in vestibular reflexes respond to identical head movements with a wide range of firing responses. This diversity of firing dynamics has been commonly assumed to arise from differences in the types of vestibular nerve inputs to vestibular nucleus neurons. In this study we show that, independent of the nature of inputs, the intrinsic membrane properties of neurons in the medial vestibular nucleus substantially influence firing response dynamics. Hyperpolarizing and depolarizing inputs evoked a markedly heterogenous range of firing responses. Strong postinhibitory rebound firing (PRF) was associated with strong firing rate adaptation (FRA) and occurred preferentially in large multipolar neurons. In response to sinusoidally modulated input current, these neurons showed a pronounced phase lead with respect to neurons lacking strong PRF and FRA. A combination of the hyperpolarization-activated H current and slow potassium currents contributed to PRF, whereas FRA was predominantly mediated by slow potassium currents. An integrate-and-fire-type model, which simulated FRA and PRF, reproduced the phase lead observed in large neurons and showed that adaptation currents were primarily responsible for variations in response phase. We conclude that the heterogeneity of firing dynamics observed in response to head movements in intact animals reflects intrinsic as well as circuit properties.
authors.affiliation: Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Sekirnjak
authors.forename: Sascha
authors.initials: S
authors.lastname: du Lac
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D048429:Cell Size / Q000502:physiology; D002586:Cesium / Q000494:pharmacology; D003198:Computer Simulation; D003433:Crosses, Genetic; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007473:Ion Channels / Q000037:antagonists & inhibitors / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008959:Models, Neurological; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D011188:Potassium / Q000378:metabolism; D011743:Pyrimidines / Q000494:pharmacology; D026941:Sodium Channel Blockers / Q000494:pharmacology; D014726:Vestibular Nuclei / Q000166:cytology / Q000187:drug effects / Q000502:physiology*
chemical_list: D002121:Calcium Channel Blockers; D007473:Ion Channels; D011743:Pyrimidines; D026941:Sodium Channel Blockers; C082246:ICI D2788; D002586:Cesium; D011188:Potassium