title: [Changes in perinatal care as a determinant of the level and diversity of antiinfectives use in a neonatal intensive care unit in Rio de Janeiro, Brazil].
abstract: This study focuses on a five-year profile (1990-1994) in the utilization of antiinfectives in a neonatal intensive care unit (NICU) in Rio de Janeiro, Brazil. Total antiinfectives consumption, diversity, and possible determinants were analyzed. A descriptive, longitudinal, and retrospective drug utilization study design was adopted. Document research, observation, and semi-structured interviews provided information on the neonatal intensive care provided, and drug supply and daily hospital records provided data on antiinfectives use, based on the Anatomical Therapeutic Chemical (ATC) classification and the infant defined daily dose (DDDi) as units of measurement. The numerical results suggest an increase in total consumption of antiinfectives and a decrease in their diversity. Analyzed in view of the institutional profile and rational drug use, these results indicate that changes in the type of care provided during the study period were key determinants of antiinfectives use.
authors.affiliation: Núcleo de Assistência Farmacêutica, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, 21041-210, Brasil. claudia@iff.fiocruz.br
authors.forename: Claudia Garcia Serpa
authors.initials: CG
authors.lastname: Osorio-De-Castro
authors.forename: Maurício Abreu Pinto
authors.initials: MA
authors.lastname: Peixoto
authors.forename: Selma Rodrigues de
authors.initials: SR
authors.lastname: Castilho
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001938:Brazil; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008137:Longitudinal Studies; D012189:Retrospective Studies
chemical_list: D000890:Anti-Infective Agents