title: Feasibility study of a system for combined light dosimetry and interstitial photodynamic treatment of massive tumors.
abstract: A system for the photodynamic laser treatment of massive tumors that employs multiple optical fibers to be inserted into the tumor mass is described. The light flux through the tumor can be assessed by use of the individual fibers both as transmitters and as receivers. With a computer model that describes the diffusive light propagation, optical dosimetry is under development. The system has been tested in an experimental animal tumor model in preparation for clinical work. Currently, delta-aminolevulinic acid is used as a sensitizer, activated by 635-nm radiation from a 2.0-W compact diode laser system. With the availability of future, highly selective drugs absorbing approximately 750 nm, larger tumor volumes should be treatable, and surrounding, sensitive normal tissue should be spared.
authors.affiliation: Department of Physics, Lund Institute of Technology, Sweden.
authors.forename: Thomas
authors.initials: T
authors.lastname: Johansson
authors.forename: Marcelo Soto
authors.initials: MS
authors.lastname: Thompson
authors.forename: Maria
authors.initials: M
authors.lastname: Stenberg
authors.forename: Klinteberg Claes
authors.initials: KC
authors.lastname: af
authors.forename: Stefan
authors.initials: S
authors.lastname: Andersson-Engels
authors.forename: Sune
authors.initials: S
authors.lastname: Svanberg
authors.forename: Katarina
authors.initials: K
authors.lastname: Svanberg
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D005240:Feasibility Studies; D005453:Fluorescence; D006614:Hindlimb; D053685:Laser Therapy; D008027:Light; D009368:Neoplasm Transplantation; D010778:Photochemotherapy / Q000295:instrumentation; D011874:Radiometry; D051381:Rats; D011920:Rats, Inbred WF; D012984:Software