title: Is there an increased maternal-infant prevalence of Factor V Leiden in association with severe pre-eclampsia?
abstract: OBJECTIVE
  To compare the prevalence of the Factor V Leiden mutation in children and maternal-infant pairs in pregnancies affected by severe pre-eclampsia with unmatched normal controls.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Department of Women's and Children's Health, The Canberra Hospital, Garran, ACT, Australia.
  
  
  METHODS
  Forty-eight maternal-infant pairs where the index pregnancy was affected by severe pre-eclampsia; 46 unmatched maternal-infant pairs where the index pregnancy was defined as normal.
  
  
  METHODS
  DNA analysis of cheek swab samples obtained from maternal-infant pairs for the Factor V Leiden mutation.
  
  
  METHODS
  The prevalence of the Factor V Leiden mutation in mothers, infants and maternal-infant pairs in association with severe pre-eclampsia compared with unmatched controls.
  
  
  RESULTS
  No difference was detected in the prevalence of Factor V Leiden mutation between the women and children of both groups, nor the maternal-infant pairs from each group.
  
  
  CONCLUSIONS
  No evidence was found of an increased prevalence of the Factor V Leiden mutation in either the mothers or children in association with severe pre-eclampsia. This result argues against a Factor V Leiden fetal or maternal contribution to the development of severe pre-eclampsia.
authors.affiliation: Department of Women's and Children's Health, The Canberra Hospital, Garran, ACT, Australia.
authors.forename: Lea
authors.initials: L
authors.lastname: Currie
authors.forename: Michael
authors.initials: M
authors.lastname: Peek
authors.forename: Michelle
authors.initials: M
authors.lastname: McNiven
authors.forename: Ian
authors.initials: I
authors.lastname: Prosser
authors.forename: Julia
authors.initials: J
authors.lastname: Mansour
authors.forename: Jennifer
authors.initials: J
authors.lastname: Ridgway
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009154:Mutation / Q000235:genetics*; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: C095381:factor V Leiden; D005165:Factor V