Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.
Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.
Brakebusch
Cord
C
Lund University, 22185 Lund, Sweden. brakebus@biochem.mpg.de
Fillatreau
Simon
S
Potocnik
Alexandre J
AJ
Bungartz
Gerd
G
Wilhelm
Patricia
P
Svensson
Marcus
M
Kearney
Phil
P
Körner
Heinrich
H
Gray
David
D
Fässler
Reinhard
R
D000818:Animals; D000917:Antibody Formation / Q000235:genetics* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D017353:Gene Deletion; D005786:Gene Expression Regulation / Q000276:immunology; D006410:Hematopoiesis / Q000235:genetics*; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D019012:Integrin beta1 / Q000235:genetics* / Q000276:immunology; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D007075:Immunoglobulin M; D019012:Integrin beta1