title: Epstein-Barr virus-associated B-cell lymphoproliferative disorders in angloimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified.
abstract: Various patterns of Epstein-Barr virus (EBV)-associated B-cell lymphoproliferation occur in patients with immunodeficiency. We studied 17 cases of T-cell lymphoma displaying extensive EBV-driven B-cell lymphoproliferation or simultaneous/subsequent EBV-associated B-cell lymphoma. In 10 cases of angioimmunoblastic T-cell lymphoma, an uncommonly prominent population of EBV+ atypical, activated, focally confluent large transformed B cells was found in the background of T-cell lymphoma. In 4 cases, an EBV-associated B-cell neoplasm (3 diffuse large B-cell lymphomas, 1 plasmacytoma) occurred in patients with T-cell lymphoma. Three cases were composite lymphomas of a peripheral T-cell lymphoma, unspecified, combined with EBV-associated diffuse large B-cell lymphoma. The transformed B-cell population displayed EBV latency types 2 and 3. Monoclonal and oligoclonal B-cell populations were detected in 5 and 6 cases, respectively. Similar to other states of immunodeficiency, disease-related and therapy-induced immunosuppression in T-cell lymphoma may lead to a prominent EBV-associated B-cell lymphoproliferation and to EBV+ B-cell neoplasms.
authors.affiliation: Institute of Pathology, University of Würzburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Zettl
authors.forename: Seung-Sok
authors.initials: SS
authors.lastname: Lee
authors.forename: Thomas
authors.initials: T
authors.lastname: Rüdiger
authors.forename: Petr
authors.initials: P
authors.lastname: Starostik
authors.forename: Mirella
authors.initials: M
authors.lastname: Marino
authors.forename: Thomas
authors.initials: T
authors.lastname: Kirchner
authors.forename: Michaela
authors.initials: M
authors.lastname: Ott
authors.forename: Hans Konrad
authors.initials: HK
authors.lastname: Müller-Hermelink
authors.forename: German
authors.initials: G
authors.lastname: Ott
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001402:B-Lymphocytes; D002471:Cell Transformation, Neoplastic; D005260:Female; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D004854:Herpesvirus 4, Human; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000150:complications / Q000473:pathology / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000473:pathology / Q000821:virology; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000150:complications* / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged