Pharmacogenetics and antiepileptic drugs.
Responses among patients to antiepileptic drugs (AEDs) may be highly variable, with respect to both drug efficacy and safety. Pharmacogenetics addresses the genetic component of such patient variability. Differential response to phenytoin, for example, is related to interindividual genetic differences in the metabolic enzyme CYP2C9, and to a lesser extent, CYP2C19. However, no other AED responses have yet been linked conclusively to specific genes. Further understanding of the role of genes in AED response will depend on clinical investigations coupled with new information and technologies derived from the Human Genome Project. Once the DNA sequences involved in specific AED responses are understood, they can be used as the basis of clinical assays to predict the most likely response in each individual patient. The combination of clinical investigations, genomics, and emerging testing methodologies should lead to new tools for the effective management of epilepsy.
Spear
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BB
Pharmacogenetics Department, Abbott Laboratories, Abbott Park, Illinois 60064-6008, USA. brian.spear@abbott.com
D000927:Anticonvulsants / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D015195:Drug Design; D004351:Drug Resistance / Q000235:genetics; D004827:Epilepsy / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D023281:Genomics / Q000639:trends; D005838:Genotype; D006801:Humans; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic
D000927:Anticonvulsants