title: [New concepts in the biology of acute myeloid leukemia].
abstract: During the last 20 years, several concepts regarding the biology of acute myeloid leukemia (AML) have changed in a profound manner. This has been mainly due to significant advances in the identification, purification and characterization of the primitive hematopoietic cells--including stem and progenitor cells--in which this disorder originates. In the present review article, we discuss some of these new concepts and their relevance in the treatment of AML.
authors.affiliation: Unidad de Investigación en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, IMSS. Av. Cuauhtémoc 330, Col. Doctores México, D.F. 06720.
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Montesinos
authors.forename: Héctor
authors.initials: H
authors.lastname: Mayani
mesh_terms: D018952:Antigens, CD34 / Q000096:biosynthesis; D006410:Hematopoiesis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology* / Q000473:pathology
chemical_list: D018952:Antigens, CD34