Effect of neonatal interleukin-6 (IL-6) treatment (hormonal imprinting) on the IL-6 content and localization of the peritoneal, blood and thymic cells of adult rats. A confocal microscopic analysis.
Single treatment of newborn rat with human recombinant interleukin-6 (IL-6) durably increases IL-6 content in certain cell types of the adult animal. Peritoneal mast cells contain a high quantity of IL-6, in contrast to controls which contain no IL-6. In addition, many other (mainly lymphatic) cells of the peritoneal fluid contain IL-6. However, IL-6 is present in the control thymocytes, in smaller amounts than in the neonatally IL-6 imprinted cells. In the blood, the number of IL-6 containing cells also increases after imprinting (lymphocytes and developing forms of mast cells).
Csaba
G
G
Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary.
Kovács
P
P
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000008:administration & dosage* / Q000097:blood / Q000502:physiology*; D008214:Lymphocytes / Q000502:physiology*; D008407:Mast Cells / Q000502:physiology*; D018613:Microscopy, Confocal; D010529:Peritoneal Cavity / Q000166:cytology / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013950:Thymus Gland / Q000166:cytology / Q000502:physiology; D013997:Time Factors
D015850:Interleukin-6