Comparative antibiotic resistance of diarrheal pathogens from Vietnam and Thailand, 1996-1999.
Antimicrobial resistance rates for shigella, campylobacter, nontyphoidal salmonella, and enterotoxigenic Escherichia coli were compared for Vietnam and Thailand from 1996 to 1999. Resistance to trimethoprim-sulfamethoxazole, ampicillin, chloramphenicol, and tetracycline was common. Quinolone resistance remains low in both countries, except among campylobacter and salmonella organisms in Thailand. Nalidixic acid resistance among salmonellae has more than doubled since 1995 (to 21%) in Thailand but is not yet documented in Vietnam. Resistance to quinolones correlated with resistance to azithromycin in both campylobacter and salmonella in Thailand. This report describes the first identification of this correlation and its epidemiologic importance among clinical isolates. These data illustrate the growing magnitude of antibiotic resistance and important differences between countries in Southeast Asia.
Isenbarger
Daniel W
DW
Armed Forces Research Institute of Medical Science, Bangkok, Thailand. isenbargerdw@hotmail.com
Hoge
Charles W
CW
Srijan
Apichai
A
Pitarangsi
Chittima
C
Vithayasai
Niyada
N
Bodhidatta
Ladaporn
L
Hickey
Kimberly W
KW
Cam
Phung Dac
PD
D042462:4-Quinolones; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D003967:Diarrhea / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007223:Infant; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D013785:Thailand / Q000453:epidemiology; D014744:Vietnam / Q000453:epidemiology
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D018942:Macrolides