title: Nucleoprotein structure of immediate-early promoters Zp and Rp and of oriLyt of latent Epstein-Barr virus genomes.
abstract: Genomic footprints across Rp, Zp, and oriLyt of Epstein-Barr virus (EBV) have been conducted in a panel of latently infected B-cell lines. Close protein-base contacts were found about 360 nucleotides upstream of the Zp initiation site. Gel shifts and transient transfection assays indicated that an Sp1-NF1 locus may serve as a repressive transcriptional element against Zp induction from latent EBV genomes.
authors.affiliation: Institut für Medizinische Mikrobiologie und Hygiene, Universität Regensburg, D-93053 Regensburg, Germany. Hans-Helmut.Niller@klinik.uni-regensburg.de
authors.forename: Hans Helmut
authors.initials: HH
authors.lastname: Niller
authors.forename: Daniel
authors.initials: D
authors.lastname: Salamon
authors.forename: Jörg
authors.initials: J
authors.lastname: Uhlig
authors.forename: Stefanie
authors.initials: S
authors.lastname: Ranf
authors.forename: Marcus
authors.initials: M
authors.lastname: Granz
authors.forename: Fritz
authors.initials: F
authors.lastname: Schwarzmann
authors.forename: Hans
authors.initials: H
authors.lastname: Wolf
authors.forename: Janos
authors.initials: J
authors.lastname: Minarovits
mesh_terms: D001402:B-Lymphocytes; D001483:Base Sequence; D002460:Cell Line; D018983:DNA Footprinting; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000502:physiology*; D006801:Humans; D017874:Immediate-Early Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D009698:Nucleoproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic / Q000235:genetics; D017735:Virus Latency
chemical_list: D017874:Immediate-Early Proteins; D009698:Nucleoproteins