title: Arthropod bites manifesting as recurrent bullae in a patient with chronic lymphocytic leukemia.
abstract: BACKGROUND
  We report a patient with chronic lymphocytic leukemia (CLL) that developed recurrent vesicobullous lesions that histologically demonstrated features of an exaggerated response to an arthropod bite.
  
  
  OBJECTIVE
  Patients with CLL can present with many cutaneous manifestations, including specific and nonspecific lesions. Although rare, patients with CLL can develop an exaggerated response to an arthropod bite.
  
  
  CONCLUSIONS
  Emphasis needs to be placed on the clinical recognition of arthropod bites as an unusual cutaneous manifestation of CLL, as they provide the physician with both a diagnostic and a therapeutic challenge. Patients often deny being bitten and, thus, the biopsy results conflict with the patient's history. Additionally, as there is no specific treatment, both the patient and physician are faced with a similar dilemma. Although our patient initially responded well to corticosteroids, his lesions significantly improved while being treated with dapsone.
authors.affiliation: Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: R R
authors.initials: RR
authors.lastname: Blum
authors.forename: R G
authors.initials: RG
authors.lastname: Phelps
authors.forename: H
authors.initials: H
authors.lastname: Wei
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001181:Arthropods; D001706:Biopsy; D001768:Blister / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003622:Dapsone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006801:Humans; D007299:Insect Bites and Stings / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012867:Skin / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003622:Dapsone