Col2-GFP reporter mouse--a new tool to study skeletal development.
Transgenic mice were generated that harbor a Col2-GFP reporter that marks chondrocytes and their immediate precursors during skeletal development. Cells engaged in chondrogenesis were identified by conventional fluorescence microscopy and confocal optical sectioning within their native environments in live embryos and in thick tissue slices. The use of these mice offers a novel approach for studying the role of chondrocytes in skeletal development.
Cho
J Y
JY
Research Center, Shriners Hospital for Children, Portland, OR 97201, USA.
Grant
T D
TD
Lunstrum
G P
GP
Horton
W A
WA
D000818:Animals; D001846:Bone Development; D019902:Chondrocytes / Q000502:physiology; D024043:Collagen Type II / Q000235:genetics* / Q000502:physiology; D004195:Disease Models, Animal; D017930:Genes, Reporter / Q000502:physiology; D049452:Green Fluorescent Proteins; D008164:Luminescent Proteins / Q000235:genetics* / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D009928:Organ Specificity / Q000502:physiology
D024043:Collagen Type II; D008164:Luminescent Proteins; D049452:Green Fluorescent Proteins