title: The historical and current application of the FIB-1 model to assess organ dose from plutonium intakes in Mayak workers.
abstract: One of the objectives of the Joint Coordinating Committee for Radiation Effects Research Project 2.4 is to document the methodology used to determine the radiation doses in workers from the Mayak Production Association who were exposed to plutonium. The doses have been employed in numerous dose response studies measuring both stochastic and deterministic effects. This article documents both the historical (pre-1999) and current ("Doses 1999") methods used by the FIB-1 scientists to determine the doses. Both methods are based on a three-chamber lung model developed by the FIB-1 scientists. This method was developed in partial isolation from the West and has unique characteristics from the more familiar ICRP biokinetic models. Some of these characteristics are the use of empirically based transportability classifications and the parameter modification for chelation-therapy-enhanced excretion data. An example dose calculation is provided and compared to the dose that would be obtained if the ICRP models were used. The comparison demonstrates that the models are not interchangeable and produce different results.
authors.affiliation: Center for Excellence in Nuclear Technology, Engineering, and Research, University of Utah, Salt Lake City 84054, USA. mpk@nuclear.utah.edu
authors.forename: Melinda P
authors.initials: MP
authors.lastname: Krahenbuhl
authors.forename: David M
authors.initials: DM
authors.lastname: Slaughter
authors.forename: Justin L
authors.initials: JL
authors.lastname: Wilde
authors.forename: John D
authors.initials: JD
authors.lastname: Bess
authors.forename: Scott C
authors.initials: SC
authors.lastname: Miller
authors.forename: Valentin F
authors.initials: VF
authors.lastname: Khokhryakov
authors.forename: Klara G
authors.initials: KG
authors.lastname: Suslova
authors.forename: Vadim V
authors.initials: VV
authors.lastname: Vostrotin
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Romanov
authors.forename: Zoya S
authors.initials: ZS
authors.lastname: Menshikh
authors.forename: Tamara I
authors.initials: TI
authors.lastname: Kudryavtseva
mesh_terms: D006801:Humans; D008954:Models, Biological; D016273:Occupational Exposure; D011005:Plutonium / Q000493:pharmacokinetics*; D011210:Power Plants; D011834:Radiation Monitoring / Q000379:methods; D014018:Tissue Distribution; D014556:Urine / Q000737:chemistry
chemical_list: D011005:Plutonium