Crystal packing and hydrogen bonding in platinum(II) nucleotide complexes: X-ray crystal structure of [Pt(MeSCH(2)CH(2)SMe)(5'-GMP-N7)(2)].6H(2)O.
We have synthesised the complex [Pt(CH(3)SCH(2)CH(2)SCH(3))(5'-GMP-N7)(2)].6H(2)O (1), where 5'-GMP is 5'-guanosine monophosphate, and determined its X-ray crystal structure. Pt(II) adopts a square-planar geometry in which the bases are coordinated head-to-tail (HT) in the Delta configuration. The nucleotide conformation in this complex is almost identical to that in the previously reported complex [Pt(en)(5'-GMP-N7)(2)].9H(2)O (2), in which there is outer sphere macrochelation via intramolecular H-bonding between the monoanionic phosphate groups and the coordinated ethylenediamine (en) NH. It is therefore apparent that intermolecular interactions rather than intramolecular H-bonding determines the orientation of the sugar-phosphate side-chain in these Pt(II) bisnucleotide complexes in the solid state.
Djuran
Milos I
MI
Department of Chemistry, University of Kragujevac, R. Domanovica 12, P.O. Box 60, 34000 Kragujevac, Yugoslavia.
Milinkovic
Snezana U
SU
Habtemariam
Abraha
A
Parsons
Simon
S
Sadler
Peter J
PJ
D003460:Crystallization; D018360:Crystallography, X-Ray; D006157:Guanosine Monophosphate / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009944:Organoplatinum Compounds / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry*
D009944:Organoplatinum Compounds; D013440:Sulfides; D006157:Guanosine Monophosphate