title: [Percutaneous revascularization of multivessel coronary disease using stents - a multicenter, prospective study].
abstract: OBJECTIVE
  Symptomatic patients with multivessel coronary disease (MVD) benefit from both coronary artery bypass grafting (CABG) and percutaneous coronary angioplasty (PTCA). The >>German Angioplasty Bypass Investigation<< (GABI-I) trial randomized patients to one of these treatment strategies between 1986 and 1991. In order to evaluate the impact of current technology, in particular coronary stents, the GABI-II trial was initiated, which in 1996 and 1997 prospectively enrolled patients according to the initial GABI-I criteria.
  
  
  METHODS
  Into the study 136 consecutive patients (108 men, 28 women; 63 +/- 12 years) were included. Patients from GABI-I served as controls.
  
  
  RESULTS
  A mean of 2.1 +/- 0.5 vessels were treated per patient (vs. 1.9 +/- 0.5 vessels in the PTCA arm of GABI-I) and 63 % of the lesions were covered with stents. With respect to the primary endpoint less patients remained with a CCS class III or IV in GABI-II after 12 months (1,5 % vs. 8 % in the PTCA arm of GABI-I, p<0,01). No patient required emergency or urgent bypass operation in GABI-II (vs. 9 % in GABI-I, p < 0.01). After 12 months, 8 % of the patients were sent for bypass surgery (CABG) vs. 21 % in GABI-I (p < 0.001), and 20 % (vs. 23 % in GABI-I) of the patients underwent Re-PTCA. The percentage of patients without reinterventions was 72 % vs. 56 % in GABI-I (p < 0.01), but remained lower compared to patients randomized to CABG in GABI-I (94 %, p < 0.001).
  
  
  CONCLUSIONS
  PTCA in patients with MVD is still associated with a higher reintervention rate as compared with CABG. However, in contrast to angioplasty a decade ago, PTCA in conjunction with stents significantly lowered the need for subsequent revascularization, which was mainly driven by the reduced necessity for bypass surgery.
authors.affiliation: Abteilung für Kardiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Baldus
authors.forename: R
authors.initials: R
authors.lastname: Köster
authors.forename: R
authors.initials: R
authors.lastname: Küchler
authors.forename: J
authors.initials: J
authors.lastname: v  Dahl
authors.forename: U
authors.initials: U
authors.lastname: Dietz
authors.forename: W
authors.initials: W
authors.lastname: Voelker
authors.forename: J
authors.initials: J
authors.lastname: Reimers
authors.forename: K H
authors.initials: KH
authors.lastname: Kuck
authors.forename: A
authors.initials: A
authors.lastname: Sasse
authors.forename: J H
authors.initials: JH
authors.lastname: Rupprecht
authors.forename: B
authors.initials: B
authors.lastname: Sieburg
authors.forename: J
authors.initials: J
authors.lastname: Meyer
authors.forename: J
authors.initials: J
authors.lastname: Berger
authors.forename: T
authors.initials: T
authors.lastname: Meinertz
authors.forename: C W
authors.initials: CW
authors.lastname: Hamm
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery / Q000628:therapy*; D003627:Data Interpretation, Statistical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D015607:Stents; D013997:Time Factors