AIDS and AIDS-treatment neuropathies.
AIDS and AIDS-treatment neuropathies are common in individuals infected with HIV. As patients live longer due to improved antiretroviral therapies, the impact of painful neuropathy on patients' lives may increase. Several antiretroviral medications are known to cause toxic neuropathy in AIDS patients; but this may be outweighed by the beneficial effects of viral suppression. Current theories on the pathogenesis of AIDS neuropathies include mitochondrial toxicity secondary to gamma-DNA polymerase inhibition and subsequent abnormal mitochondrial DNA synthesis. Treatment of AIDS neuropathies is directed toward relief of symptoms, however, new evidence suggests that aggressive antiretroviral therapy may also be effective.
Williams
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Neuro-AIDS Research Program, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1052, New York, NY 10029, USA.
Geraci
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A
Simpson
D M
DM
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000700:Analgesics / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000009:adverse effects*; D000928:Antidepressive Agents / Q000627:therapeutic use; D006801:Humans; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000821:virology*
D000700:Analgesics; D019380:Anti-HIV Agents; D000928:Antidepressive Agents