Parenteral lipid emulsions and phagocytic systems.
Lipid emulsions (LE) for parenteral use are complex emulsions containing fatty acids, glycerol, phospholipids and tocopherol in variable amounts and concentrations. In clinical practice, LE have been employed for more than 30 years. Fatty acids may have different impacts on phagocytic cells according to their structure. Experimental and clinical studies have consistently shown that LE modify monocyte/macrophage and polymorphonuclear phagocytosis. The inhibitory effect of LE on the functional activity of the phagocytic system, although still clinically controversial, may have a harmful impact because total parenteral nutrition with lipids may be recommended in hypercatabolic conditions where inflammation and infection are present. LE based on triglycerides containing long chain fatty acids (termed long chain triglycerides or LCT) are the main parenteral fat source and are typically rich in n-6 polyunsaturated fatty acids. They may have adverse effects on the immune system, especially when given in high doses over a short period of time. However when administered properly they can be used safely. LE containing medium chain triglycerides (MCT) may have some advantages because of their positive effects on polymorphonuclear cells, macrophages, and cytokine production, particularly in critically ill or immunocompromised patients. New parenteral LE containing n-3 polyunsaturated fatty acids or monounsaturated olive oil are already available in Europe. Judicious use of these new LE is mandatory especially relating on their potential impact on the immune system. New experimental and clinical studies are required to further establish the role of LE in clinical nutrition.
Waitzberg
D L
DL
Departamento de Gastroenterologia, Faculdade de Medicina da Universidade de São Paulo, FMUSP, Brazil. d.waitzberg@terra.com.br
Lotierzo
P H
PH
Logullo
A F
AF
Torrinhas
R S M
RS
Pereira
C C A
CC
Meier
Rémy
R
D000818:Animals; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D006801:Humans; D007107:Immune System / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D009000:Monocytes / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D010289:Parenteral Nutrition, Total; D010587:Phagocytosis / Q000187:drug effects*
D005217:Fat Emulsions, Intravenous