title: Cisplatin induces modifications in the development of cell surface patterns of ciliates.
abstract: Cisplatin [cis-dichlorodiammineplatinum (II)] brings about significant quantitative modifications in the development of cell surface patterns in two unrelated ciliates: Stylonychia and Tetrahymena. Cells cultured in the presence of cisplatin exhibit the formation of supernumerary surface structures in the form of extra cilia/cirri (fused cilia) and other organized ciliary organelles. The metal-induced formation of extra primordia and their differentiation into supernumerary ciliary structures is governed by the normal rules of development. Additional structures are accommodated within the framework of a defined pattern, suggesting the existence of an overall global control of pattern formation. The modified pattern is rectified to its normal state during post-treatment fission cycles, suggesting the role of the cell membrane in correcting developmental errors.
authors.affiliation: Department of Zoology, University of Delhi, India.
authors.forename: S
authors.initials: S
authors.lastname: Machwe
authors.forename: S
authors.initials: S
authors.lastname: Arora
authors.forename: R
authors.initials: R
authors.lastname: Gupta
authors.forename: G R
authors.initials: GR
authors.lastname: Sapra
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000502:physiology / Q000648:ultrastructure; D002923:Cilia / Q000000981:diagnostic imaging* / Q000187:drug effects*; D016798:Ciliophora / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D002945:Cisplatin / Q000494:pharmacology*; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D013768:Tetrahymena / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D014463:Ultrasonography
chemical_list: D003432:Cross-Linking Reagents; D002945:Cisplatin