title: [In situ hybridization in undifferentiated nasopharynx carcinoma in Tunisia. Report of 3 cases].
abstract: The undifferentiated carcinoma of nasopharyngeal type (UCNT) is highly prevalent in South East Asia countries and has intermediate incidence in Tunisia, where Epstein-Barr virus constitutes one of the key factors of oncogenesis. Our preliminary results, in 3 patients with UCNT, show an elevated rate of EBV antibodies and a latent infection (type II) (expression of LMP and absence of ZEBRA by immunohistochemical reaction) and a positive staining with EBERs probe by in situ hybridation (ISH) in all cases. These results confirm a close association between EBV and tunisian UCNT. Moreover, the use of HIS technique for detection of EBERs constitutes an additional and formal argument of this association.
authors.affiliation: Institut Salah Azaiz, Tunis.
authors.forename: M
authors.initials: M
authors.lastname: Baizig Nehla
authors.forename: B
authors.initials: B
authors.lastname: Hamouda
authors.forename: K
authors.initials: K
authors.lastname: Asma
authors.forename: B A
authors.initials: BA
authors.lastname: Farhat
authors.forename: L
authors.initials: L
authors.lastname: Abderahmen
authors.forename: B H
authors.initials: BH
authors.lastname: Omrane
authors.forename: el M
authors.initials: el M
authors.lastname: Ahmed
mesh_terms: D000293:Adolescent; D000328:Adult; D002277:Carcinoma / Q000235:genetics / Q000473:pathology / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000235:genetics; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000473:pathology / Q000821:virology*; D014416:Tunisia