Role of the NF-kappaB pathway in the pathogenesis of human disease states.
The NF-kappaB family consists of a group of inducible transcription factors which regulate immune and inflammatory responses and protect cells from undergoing apoptosis in response to cellular stress. A number of signal transduction cascades can activate the NF-kappaB pathway to result in the translocation of the NF-kappaB proteins from the cytoplasm to the nucleus where they activate the expression of specific cellular genes. In this review, we discuss cellular genes which are regulated by NF-kappaB and disease states which are associated with constitutive activation of the NF-kappaB pathway. Strategies to prevent prolonged activation of the NF-kappaB pathway are also discussed.
Yamamoto
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Department of Medicine, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas 75390-8594, USA.
Gaynor
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D000544:Alzheimer Disease / Q000209:etiology; D001161:Arteriosclerosis / Q000209:etiology; D001172:Arthritis, Rheumatoid / Q000209:etiology; D001249:Asthma / Q000209:etiology; D003920:Diabetes Mellitus / Q000209:etiology; D004194:Disease / Q000209:etiology*; D005786:Gene Expression Regulation; D006801:Humans; D007184:Incontinentia Pigmenti / Q000209:etiology; D007249:Inflammation / Q000209:etiology; D015212:Inflammatory Bowel Diseases / Q000209:etiology; D008954:Models, Biological; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000209:etiology; D015398:Signal Transduction
D016328:NF-kappa B