title: Multifocal electroretinogram with a multiflash stimulation technique in open-angle glaucoma.
abstract: OBJECTIVE
  To analyze a multiflash multifocal electroretinogram in 20 patients with open-angle glaucoma (OAG).
  
  
  METHODS
  The stimulation sequence consisted of a binary m-sequence (L(max) 200 cd/m(2), L(min) <1 cd/m(2)). Each m-sequence stimulus was followed by three global flashes (luminance: 400 cd/m(2)) at an interval of 26 ms.
  
  
  RESULTS
  The presence of a response to the three global flashes indicated an adaptive effect of the response to the preceding m-sequence stimulus. In the nasal retinal response average the relative amplitude contribution of the response to the second global flash in relation to the other two global flash responses was outside the range of normal (10th-90th percentile) in 10 of 20 OAG patients.
  
  
  CONCLUSIONS
  The changes in the relative contribution of the response to the second global flash seem indicative of impaired adaptive effects presumably due to inner retinal damage.
authors.affiliation: Universitätsaugenklinik, Homburg, Germany. auapal@med-rz.uni-sb.de
authors.forename: A M
authors.initials: AM
authors.lastname: Palmowski
authors.forename: R
authors.initials: R
authors.lastname: Allgayer
authors.forename: B
authors.initials: B
authors.lastname: Heinemann-Vernaleken
authors.forename: K W
authors.initials: KW
authors.lastname: Ruprecht
mesh_terms: D000328:Adult; D004596:Electroretinography / Q000379:methods*; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D010775:Photic Stimulation; D012160:Retina / Q000473:pathology*