title: Stereoselective construction of eight-membered carbocycles by brook rearrangement-mediated [3 + 4] annulation.
abstract: [reaction: see text] A newly developed strategy for eight-membered carbocycles via [3 + 4] annulation that involves the combination of beta-substituted acryloylsilanes and enolates of cycloheptenone is described. A unique feature of this annulative approach is its capacity to generate, in two steps, eight-membered ring systems containing useful functionalities for further synthetic elaboration from readily available three- and four-carbon components.
authors.affiliation: Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, 1-2-3 Kasumi, Hiroshima 734-8551, Japan. takedak@hiroshima-u.ac.jp
authors.forename: Kei
authors.initials: K
authors.lastname: Takeda
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sawada
authors.forename: Koichi
authors.initials: K
authors.lastname: Sumi