title: The basal ganglia and disorders of movement: pathophysiological mechanisms.
abstract: The basal ganglia are part of a neuronal network organized in parallel circuits. The "motor circuit" is most relevant to the pathophysiology of movement. Abnormal increment or reduction in the inhibitory output activity of basal ganglia give rise, respectively, to poverty and slowness of movement (i.e., Parkinson's disease) or dyskinesias.
authors.affiliation: Department of Neurology, Clinica Universitaria and Medical School, University of Navarra, Pamplona 31008, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Obeso
authors.forename: María C
authors.initials: MC
authors.lastname: Rodríguez-Oroz
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodríguez
authors.forename: Javier
authors.initials: J
authors.lastname: Arbizu
authors.forename: José M
authors.initials: JM
authors.lastname: Giménez-Amaya
mesh_terms: D001479:Basal Ganglia / Q000166:cytology / Q000503:physiopathology*; D006801:Humans; D009069:Movement Disorders / Q000503:physiopathology*; D009434:Neural Pathways