title: Possible improvement of the clitoral and vaginal blood flow using a somatostatin analog in chronic spinalized Sprague-Dawley rats.
abstract: We evaluated the effect of a somatostatin analog (octreotide) on clitoral and vaginal blood flow following suprasacral spinal cord injury (SCI) in rats. Twenty-four spinalized female Sprague-Dawley rats were randomized into 4 equal groups. The first group served as control paraplegics. The other three groups received octreotide (60 micrograms/day/4 weeks) immediately, 2 weeks, and 4 weeks following SCI. At the end of the experiment, a laser Dopper was used to measure blood flow changes following clitoral and pelvic nerve plexus stimulations. Marked decreases in both clitoral and vaginal blood flow in the control paraplegics were recorded. Significant increases (p < 0.05) in both clitoral and vaginal blood flow were recorded in animals that received octreotide; however, the increase was marked in the animals that received the drug immediately following SCI. Improvement in the clitoral and vaginal blood flow of spinalized rats using octreotide indicates that octreotide may be helpful for patients with SCI.
authors.affiliation: Urology Research Laboratory, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: Aly M
authors.initials: AM
authors.lastname: Abdel-Karim
authors.forename: Serge
authors.initials: S
authors.lastname: Carrier
mesh_terms: D000818:Animals; D002987:Clitoris / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000187:drug effects; D004599:Electric Stimulation Therapy / Q000379:methods; D005260:Female; D017078:Laser-Doppler Flowmetry / Q000379:methods; D015282:Octreotide / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000378:metabolism; D013119:Spinal Cord Injuries; D014463:Ultrasonography; D014621:Vagina / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents; D013004:Somatostatin; D015282:Octreotide