title: Spongiotic vesicular dermatitis as a cutaneous reaction pattern in seven horses.
abstract: Over a 6-year period seven adult horses of different breeds and genders developed multifocal, exudative, oozing dermatitis characterized histologically by epidermal spongiotic vesicles and perivascular eosinophilic, neutrophilic and mixed mononuclear inflammation. Three horses were pruritic. Systemic disease was not noted. Two horses had a history of recurrent urticaria (hives) and one horse had nodules or welt-type lesions that progressed to exudative, oozing lesions. Interepithelial immunoglobulin (Ig)G was detected by avidin-biotin complex-peroxidase staining, but the pattern of staining was more consistent with epithelial oedema than specific IgG deposition associated with pemphigus. The exudative oozing lesions developed under circumstances suggesting that dermal oedema progressed to intracellular and intercellular epidermal oedema, which in turn progressed to the spongiotic vesicular epidermal lesions.
authors.affiliation: Dermato Diagnostics, Edmonds, WA 98026, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Hargis
authors.forename: E G
authors.initials: EG
authors.lastname: Clark
authors.forename: D D
authors.initials: DD
authors.lastname: Duclos
authors.forename: S
authors.initials: S
authors.lastname: Leclerc
authors.forename: K
authors.initials: K
authors.lastname: West
mesh_terms: D000818:Animals; D005260:Female; D006734:Horse Diseases / Q000276:immunology* / Q000473:pathology*; D006736:Horses; D007074:Immunoglobulin G / Q000097:blood; D007428:Intradermal Tests / Q000662:veterinary; D008297:Male; D012189:Retrospective Studies; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology / Q000473:pathology / Q000662:veterinary*
chemical_list: D007074:Immunoglobulin G