Beyond nucleic acid base pairs: from triads to heptads.
Hydrogen-bonded base pairs are an important determinant of nucleic acid structure and function. However, other interactions such as base-base stacking, base-backbone, and backbone-backbone interactions as well as effects exerted by the solvent and by metal or NH(4)(+) ions also have to be taken into account. In addition, hydrogen-bonded base complexes involving more than two bases can occur. With the rapidly increasing number and structural diversity of nucleic acid structures known at atomic detail higher-order hydrogen-bonded base complexes, base polyads, have attracted much interest. This review provides an overview on the occurrence of base polyads in nucleic acid structures and describes computational studies on these nucleic acid building blocks.
Sühnel
J
J
Biocomputing Group, Institut für Molekulare Biotechnologie, Postfach 100813, D-07708 Jena, Germany.
D000818:Animals; D001482:Base Composition; D020029:Base Pairing; D019295:Computational Biology; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D011789:Quantum Theory; D018911:Trinucleotide Repeats
D009696:Nucleic Acids; D009841:Oligonucleotides