Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns.
We initiated a worldwide collaborative study, including 455 episodes of bacteremia, to elucidate the clinical patterns of Klebsiella pneumoniae. Historically, community-acquired pneumonia has been consistently associated with K. pneumoniae. Only four cases of community-acquired bacteremic K. pneumoniae pneumonia were seen in the 2-year study period in the United States, Argentina, Europe, or Australia; none were in alcoholics. In contrast, 53 cases of bacteremic K. pneumoniae pneumonia were observed in South Africa and Taiwan, where an association with alcoholism persisted (p=0.007). Twenty-five cases of a distinctive syndrome consisting of K. pneumoniae bacteremia in conjunction with community-acquired liver abscess, meningitis, or endophthalmitis were observed. A distinctive form of K. pneumoniae infection, often causing liver abscess, was identified, almost exclusively in Taiwan.
Ko
Wen-Chien
WC
National Cheng Kung University Medical College, Taiwan.
Paterson
David L
DL
Sagnimeni
Anthanasia J
AJ
Hansen
Dennis S
DS
Von Gottberg
Anne
A
Mohapatra
Sunita
S
Casellas
Jose Maria
JM
Goossens
Herman
H
Mulazimoglu
Lutfiye
L
Trenholme
Gordon
G
Klugman
Keith P
KP
McCormack
Joseph G
JG
Yu
Victor L
VL
D000293:Adolescent; D000328:Adult; D016470:Bacteremia / Q000175:diagnosis* / Q000382:microbiology*; D017714:Community-Acquired Infections / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D014943:Global Health; D006801:Humans; D007710:Klebsiella Infections / Q000175:diagnosis*; D007711:Klebsiella pneumoniae / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000175:diagnosis*; D011446:Prospective Studies; D013577:Syndrome