Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines.
The effect of two natural retinoids and synthetic retinoids with or without retinoid synergists on the proliferation and differentiation of 3 melanoma cell lines were investigated in vitro. No retinoids showed significant growth inhibitory effect on these cell lines when used alone, however, cell differentiation and significant growth inhibition were observed when treated with a combination of retinoids and a retinoid synergist. This study may suggest that, though the cells showed low susceptibilities when retinoids were treated alone, the combination of retinoids and a retinoid synergist may be effective to control the growth of canine melanoma cell lines.
Ohashi
Emi
E
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Inoue
Kaori
K
Kagechika
Hiroyuki
H
Hong
Sung-Hyeok
SH
NakagawaTakayuki
Takahashi
Tomoko
T
Mochizuki
Manabu
M
Nishimura
Ryouhei
R
Sasaki
Nobuo
N
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001552:Benzazepines / Q000494:pharmacology; D001565:Benzoates / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004285:Dogs; D004357:Drug Synergism; D020287:In Situ Nick-End Labeling; D008545:Melanoma / Q000473:pathology*; D012176:Retinoids / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D001552:Benzazepines; D001565:Benzoates; C422175:HX 630; D012176:Retinoids