[HindIII DNA-polymorphism of lipoprotein lipase gene in elderly patients with ischemic heart disease].
OBJECTIVE
To determine incidence of HindIII alleles of lipoprotein lipase (LPL) in Russian elderly patients with stable effort angina (SEA) functional class II-III regarding lipid metabolism.


METHODS
Genotyping by LPL gene was performed in 103 patients with SEA. Of them 13 patients survived myocardial infarction (MI), 29 patients had diabetes mellitus.


RESULTS
Incidence of alleles of HindIII DNA-polymorphism of LPL gene both in healthy and IHD patients is comparable with that in the West European populations.


CONCLUSIONS
Genotype H+H+ of LPL gene is one of the markers of predisposition to MI, while allele H- is one of the resistance marks.
Malygina
N A
NA
Kostomarova
I V
IV
Deriagin
G V
GV
Serova
L D
LD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000150:complications / Q000235:genetics; D004247:DNA / Q000235:genetics*; D015247:Deoxyribonuclease HindIII; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D004587:Electrophoresis, Agar Gel; D005260:Female; D005838:Genotype; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics; D017202:Myocardial Ischemia / Q000150:complications / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D004247:DNA; D008071:Lipoprotein Lipase; D015247:Deoxyribonuclease HindIII