title: Cortactin is necessary for F-actin accumulation in pedestal structures induced by enteropathogenic Escherichia coli infection.
abstract: Cortactin and the translocated intimin receptor, Tir, interacted with each other in pedestal formation in HeLa cells infected with enteropathogenic Escherichia coli (EPEC). Cortactin is shown to be necessary for organizing actin pedestals in response to EPEC, based on the expression of green fluorescent protein-fused cortactin derivatives in HeLa cells.
authors.affiliation: Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
authors.forename: Vlademir V
authors.initials: VV
authors.lastname: Cantarelli
authors.forename: Akira
authors.initials: A
authors.lastname: Takahashi
authors.forename: Itaru
authors.initials: I
authors.lastname: Yanagihara
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Akeda
authors.forename: Kinichi
authors.initials: K
authors.lastname: Imura
authors.forename: Toshio
authors.initials: T
authors.lastname: Kodama
authors.forename: Gengo
authors.initials: G
authors.lastname: Kono
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Sato
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Iida
authors.forename: Takeshi
authors.initials: T
authors.lastname: Honda
mesh_terms: D000199:Actins / Q000378:metabolism*; D051356:Cortactin; D004926:Escherichia coli / Q000502:physiology*; D029968:Escherichia coli Proteins; D049452:Green Fluorescent Proteins; D006367:HeLa Cells; D006801:Humans; D008164:Luminescent Proteins / Q000378:metabolism; D008840:Microfilament Proteins / Q000737:chemistry / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology
chemical_list: D000199:Actins; C495868:CTTN protein, human; D051356:Cortactin; D029968:Escherichia coli Proteins; D008164:Luminescent Proteins; D008840:Microfilament Proteins; D011956:Receptors, Cell Surface; C109287:Tir protein, E coli; D049452:Green Fluorescent Proteins