Bone growth is impaired by uranium intoxication.
Acute and chronic uranium intoxication leads to the inhibition of bone formation and impaired bone modeling and remodeling. As these are processes directly involved in bone growth the aim of this paper is to present a biometric study of bone growth--tibiae and mandibles of rats intoxicated with uranium. Wistar ratios weighing 60-80 g were used as follows, a) one intraperitoneal injection (IPI, 2 mg/Kg of body weight)) of uranyl nitrate; b) 30 daily applications on the dorsal skin of aliquots of a mixture of U308, concentrated at 2% and at 4%--percutaneous absorption(PA)-. Tibia and mandible length were smaller in both experimental groups than in their respective controls. Some of the mandibular parameters were lower in intoxicated animals than their controls which in turn results in the alteration of the mandibular shape. We conclude that impairment in bone growth can be achieved by uranium intoxication.
Ubios
A M
AM
Department of Pathology, Faculty of Dentistry, University of Buenos Aires.
Piloni
M J
MJ
Marzorati
M
M
Cabrini
R L
RL
D000279:Administration, Cutaneous; D000818:Animals; D001846:Bone Development / Q000528:radiation effects*; D016723:Bone Remodeling / Q000528:radiation effects; D007274:Injections, Intraperitoneal; D008297:Male; D008334:Mandible / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000528:radiation effects; D014501:Uranium / Q000506:poisoning*; D014502:Uranyl Nitrate / Q000008:administration & dosage / Q000506:poisoning
D014502:Uranyl Nitrate; D014501:Uranium