title: Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purines.
abstract: A resin-capture and release strategy for making combinatorial 2,6,9-trisubstituted purine libraries is demonstrated by capturing N9-derivatized purines at the C6 position with a thio-modified polymer. The C2 fluoro group is subsequently substituted with primary and secondary amines followed by thioether oxidation and release by C6 substitution with amines and anilines. This approach complements a previously reported strategy where a 6-phenylsulfenylpurine scaffold was captured at the C2 position with a resin-bound amine.(3)
authors.affiliation: Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: Sheng
authors.initials: S
authors.lastname: Ding
authors.forename: Nathanael S
authors.initials: NS
authors.lastname: Gray
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ding
authors.forename: Xu
authors.initials: X
authors.lastname: Wu
authors.forename: Peter G
authors.initials: PG
authors.lastname: Schultz
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D011687:Purines / Q000138:chemical synthesis*
chemical_list: D004791:Enzyme Inhibitors; D011687:Purines