Effect of butanol fraction of Panax ginseng head on gastric lesion and ulcer.
From our previous result that Panax ginseng head extract had inhibition of gastric damages, the extract was fractionated. Among the hexane, chloroform, butanol and water fractions, butanol fraction showed the most potent inhibition of HCl.ethanol-induced gastric lesion, aspirin-induced gastric ulcer, acetic acid-induced ulcer and Shay ulcer. Butanol fraction showed significant increase in mucin secretion, and inhibited malondialdehyde (MDA) and H+/ K+ATPase activity in the stomach. This results indicate that the effectiveness of the fraction on gastric damages might be related to inhibition of acid secretion, increment of mucin secretion and antioxidant property.
Jeong
Choon Sik
CS
College of Pharmacy, Duksung Women's University, Seoul, Korea. choonsik@center.duksung.ac.kr
D019342:Acetic Acid; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants / Q000494:pharmacology; D001241:Aspirin; D000440:Butanols; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007723:Korea; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008861:Microsomes / Q000201:enzymology; D009077:Mucins / Q000378:metabolism; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D012997:Solvents; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D013552:Swine
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D000440:Butanols; D009077:Mucins; D010936:Plant Extracts; D012997:Solvents; D008315:Malondialdehyde; D000254:Sodium-Potassium-Exchanging ATPase; D019342:Acetic Acid; D001241:Aspirin