Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus.
An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998-1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.
Kew
Olen
O
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA. okew@cdc.gov
Morris-Glasgow
Victoria
V
Landaverde
Mauricio
M
Burns
Cara
C
Shaw
Jing
J
Garib
Zacarías
Z
André
Jean
J
Blackman
Elizabeth
E
Freeman
C Jason
CJ
Jorba
Jaume
J
Sutter
Roland
R
Tambini
Gina
G
Venczel
Linda
L
Pedreira
Cristina
C
Laender
Fernando
F
Shimizu
Hiroyuki
H
Yoneyama
Tetsuo
T
Miyamura
Tatsuo
T
van Der Avoort
Harrie
H
Oberste
M Steven
MS
Kilpatrick
David
D
Cochi
Stephen
S
Pallansch
Mark
M
de Quadros
Ciro
C
D020121:5' Untranslated Regions; D000293:Adolescent; D000818:Animals; D002213:Capsid / Q000235:genetics; D036022:Capsid Proteins; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D004293:Dominican Republic / Q000453:epidemiology; D005260:Female; D005814:Genes, Viral; D006205:Haiti / Q000453:epidemiology; D006801:Humans; D017589:Immunization Programs; D007223:Infant; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D017354:Point Mutation; D011051:Poliomyelitis / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission / Q000821:virology*; D017955:Poliovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects*; D011159:Population Surveillance; D011995:Recombination, Genetic; D014611:Vaccination; D014774:Virulence
D020121:5' Untranslated Regions; D036022:Capsid Proteins; D011055:Poliovirus Vaccine, Oral; C442540:VP1 protein, Poliovirus