title: Protein domain analysis in the era of complete genomes.
abstract: Domains present one of the most useful levels at which to understand protein function, and domain family-based analysis has had a profound impact on the study of individual proteins. Protein domain discovery has been progressing steadily over the past 30 years. What are the realistically achievable goals of sequence-based domain analysis, and how far off are they for the sequences encoded in eukaryotic genomes? Here we address some of the issues involved in better coverage of sequence-based domain annotation, and the integration of these results within the wider context of genomes, structures and function.
authors.affiliation: EMBL, Meyerhofstrasse 1, Heidelberg, Germany.
authors.forename: Richard R
authors.initials: RR
authors.lastname: Copley
authors.forename: Tobias
authors.initials: T
authors.lastname: Doerks
authors.forename: Ivica
authors.initials: I
authors.lastname: Letunic
authors.forename: Peer
authors.initials: P
authors.lastname: Bork
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030562:Databases, Protein; D005057:Eukaryotic Cells; D016678:Genome; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D011506:Proteins