[Hemolytic uremic syndrome and thrombotic thrombocytopenic purpura].
Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are thrombotic microangiopathies (TMA). Both familial and sporadic forms exist: anaemia, thrombopaenia, renal failure and neurologic disorders are common clinical features. The differential diagnosis depends on plasma levels of von Willebrand factor-cleaving protease: there is a deficiency of this protease in patients with TTP whereas its rate is normal in HUS. We remind pathophysiology, etiologies and treatment of these TMA.
Masset
C
C
Service de Néphrologie, Université de Liège.
Dubois
B
B
Rorive
G
G
D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; D000328:Adult; D000740:Anemia / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008666:Metalloendopeptidases / Q000097:blood*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis / Q000473:pathology*; D051437:Renal Insufficiency / Q000209:etiology; D013921:Thrombocytopenia / Q000209:etiology
D051722:ADAM Proteins; D008666:Metalloendopeptidases; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human