Rhabdomyosarcoma arising in mediastinal teratoma in an adult man: a case report.
We report a case of rhabdomyosarcoma which occurred in a mediastinal teratoma in a 44-year-old man. Presentation symptoms were chest pain, hoarseness and a cough. Diagnosis was fortuitous, performed by the histological and immunohistochemical study of a mediastinal tumour biopsy specimen that showed embryonal carcinoma and yolk sac tumour components associated with the rhabdomyosarcoma. After cisplatin-based chemotherapy (bleomycin-etoposide-cisplatin), surgical resection of the residual mediastinal tumour was performed. Histological and immunohistochemical study of this tumour confirmed the presence of mature teratoma and embryonal rhabdomyosarcoma. Evolution was marked by a local extension of the mediastinal tumour, occurrence of multiple metastases and bone marrow involvement. The patient died 8 months after diagnosis despite chemotherapy and radiotherapy. A review of the literature reveals that the development of rhabdomyosarcoma in primary mediastinal teratomas is unusual in adults. The diagnostic, therapeutic and prognostic implications of such an association are reviewed.
Omezzine
N
N
Department of Pneumology, Centre Hospitalier Lyon-Sud, Pierre-Benite, France.
Khouatra
C
C
Larivé
S
S
Freyer
G
G
Isaac-Pinet
S
S
Gérinière
L
L
Droz
J P
JP
Souquet
P J
PJ
D000328:Adult; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications*; D018233:Rhabdomyosarcoma, Embryonal / Q000209:etiology*; D013724:Teratoma / Q000150:complications*