title: Focus on clozapine.
abstract: Clozapine is a dibenzodiazepine derivative and a truly atypical anti-psychotic. Its therapeutic effects are probably mediated by dopaminergic and serotonergic activity. Although it appears to be the most effective antipsychotic drug for treatment-resistant schizophrenia, its general use is limited because of the risk of agranulocytosis.
authors.affiliation: Hollins Park Hospital, Warrington, Cheshire, UK.
authors.forename: M
authors.initials: M
authors.lastname: Naheed
authors.forename: B
authors.initials: B
authors.lastname: Green
mesh_terms: D000380:Agranulocytosis / Q000139:chemically induced; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D003024:Clozapine / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine