title: Cardioacceleratory effects of Manduca sexta allatotropin in the true armyworm moth, Pseudaletia unipuncta.
abstract: Manduca sexta allatotropin (Manse-AT), a peptide originally isolated on the basis of its ability to stimulate juvenile hormone (JH) biosynthesis in the tobacco hornworm, is a potent in vitro stimulator of the corpora allata (CA) in Pseudaletia unipuncta (Lepidoptera: Noctuidae). At 10(-6)M, Manse-AT stimulated in vitro rates of JH biosynthesis by CA of day 0 and 6 adult females 15- and 10-fold respectively. Both Manse-AT and serotonin were also shown to be dose-dependent stimulators of heart rate in day 0, 3 and 6 adult males and females. Furthermore, analysis suggests that there are differences in both resting and Manse-AT-stimulated heart rates depending on age and rearing conditions.
authors.affiliation: Department of Zoology, University of Toronto, M5S 3G5, Toronto, ON, Canada.
authors.forename: P M
authors.initials: PM
authors.lastname: Koladich
authors.forename: M
authors.initials: M
authors.lastname: Cusson
authors.forename: W G
authors.initials: WG
authors.lastname: Bendena
authors.forename: S S
authors.initials: SS
authors.lastname: Tobe
authors.forename: J N
authors.initials: JN
authors.lastname: McNeil
mesh_terms: D000818:Animals; D003335:Corpora Allata / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D007301:Insect Hormones / Q000494:pharmacology*; D007605:Juvenile Hormones / Q000096:biosynthesis; D008297:Male; D018402:Manduca / Q000737:chemistry*; D009036:Moths / Q000033:anatomy & histology / Q000378:metabolism*; D009479:Neuropeptides / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology
chemical_list: D007301:Insect Hormones; D007605:Juvenile Hormones; D009479:Neuropeptides; D012701:Serotonin; C050669:allatotropin