Basophils in airway disease.
The inflammatory response that is often associated with asthma is characterized by the recruitment of eosinophils, basophils, and lymphocytes. Until recently, profiling the basophil and defining its functional characteristics have been difficult. With the advent of some new tools, there is a steadily increasing body of information on the presence and potential activities of the basophil. Although the precise role of these cells in airway diseases, such as asthma, remain unclear, relatively accurate enumeration is now possible. Coupled with new insights into cytokine secretion from these cells, a more accurate picture of the dynamics of this specialized form of inflammation is available for refining our hypotheses regarding its regulation.
MacGlashan
Donald
D
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. dmacglas@mail.jhmi.edu
Gauvreau
Gail
G
Schroeder
John T
JT
D001491:Basophils / Q000502:physiology*; D006801:Humans; D018793:Interleukin-13 / Q000096:biosynthesis / Q000276:immunology; D015847:Interleukin-4 / Q000096:biosynthesis / Q000276:immunology; D011014:Pneumonia / Q000276:immunology / Q000503:physiopathology; D012130:Respiratory Hypersensitivity / Q000276:immunology* / Q000503:physiopathology*
D018793:Interleukin-13; D015847:Interleukin-4