Association of changes in the pattern of urinary calculi in Taiwanese with diet habit change between 1956 and 1999.
OBJECTIVE
Due to rapid economic development over the past four decades, urinary stone components may have changed in Taiwan. We studied the changes in urinary stone components over time and the possible association with dietary changes during the same period.


METHODS
From 1956 to 1999, 9,715 urinary calculi were collected at a single institution and analyzed using polarizing microscopy. Dietary information was obtained from an official national report. Linear regression was used to analyze the possible correlation between the change in stone components with daily consumption of animal protein, vegetable protein, and lipid.


RESULTS
Eleven distinct components were identified. Calcium oxalate (Jensen type I stone; found in sterile, acidic urine) was found most frequently (87.3%), and its incidence increased gradually with time. However, the incidence of Jensen type III stone (caused by metabolic abnormality) gradually decreased from 1956 to 1999. The male to female ratio among subjects was 2.3:1, and the modal age was in the forties. Female patients were more likely to suffer from type II stones (found in infected, alkaline urine), whereas type I and III stones were more prevalent in males. Among the dietary components, consumption of animal and vegetable proteins and lipid increased significantly during the same period, and appeared to be coincident with the increased incidence of type I stones during the study period.


CONCLUSIONS
Patterns of urinary tract stones in Taiwan have progressively changed in the past four decades and are now similar to those in western populations. The incidence of type I stones has increased during the past four decades, which may reflect the Westernization of dietary habits in Taiwanese during the same period.
Hsu
Te-Chin
TC
Department of Urology, National Taiwan University Hospital.
Chen
Jun
J
Huang
Ho-Shiang
HS
Wang
Chung-Jing
CJ
D000328:Adult; D000368:Aged; D001031:Apatites / Q000032:analysis; D002129:Calcium Oxalate / Q000032:analysis; D003553:Cystine / Q000032:analysis; D004041:Dietary Fats / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D017616:Magnesium Compounds / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000032:analysis; D000069877:Struvite; D013624:Taiwan / Q000453:epidemiology; D014527:Uric Acid / Q000032:analysis; D014545:Urinary Calculi / Q000737:chemistry* / Q000453:epidemiology
D001031:Apatites; D004041:Dietary Fats; D004044:Dietary Proteins; D017616:Magnesium Compounds; D010710:Phosphates; D002129:Calcium Oxalate; D014527:Uric Acid; D003553:Cystine; D000069877:Struvite