title: No association for D2 and D4 dopamine receptor polymorphisms and methamphetamine abuse in Chinese males.
abstract: The D2 and D4 dopamine receptors (DRD2 and DRD4) play major roles in the central effects of psychostimulants and in the reward system. Previous studies, although not all, have demonstrated associations between the DRD2 TaqI and the DRD4 exon III variable number tandem repeat (VNTR) polymorphisms and substance dependence. For this study, we have investigated the associations between these two polymorphisms and methamphetamine (MAP) dependence, as manifested in a Chinese-male sample population. No significant difference was demonstrated for genotype or allele frequency when comparing MAP-dependent and control cases for the DRD2 TaqI and the DRD4 gene exon III VNTR polymorphisms, suggesting that these two polymorphisms do not play major roles in MAP dependence for our sample of Chinese males.
authors.affiliation: Department of Psychiatry, Veterans General Hospital-Taipei, Taiwan, ROC. sjtsai@vghtpe.gov.tw
authors.forename: Shih-Jen
authors.initials: SJ
authors.lastname: Tsai
authors.forename: Chih-Ya
authors.initials: CY
authors.lastname: Cheng
authors.forename: Li-Ren Remus
authors.initials: LR
authors.lastname: Shu
authors.forename: Chin-Yi
authors.initials: CY
authors.lastname: Yang
authors.forename: Chen-Wei
authors.initials: CW
authors.lastname: Pan
authors.forename: Ying-Jay
authors.initials: YJ
authors.lastname: Liou
authors.forename: Chen-Jee
authors.initials: CJ
authors.lastname: Hong
mesh_terms: D019969:Amphetamine-Related Disorders / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002681:China; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050638:Receptors, Dopamine D4
chemical_list: C493599:DRD4 protein, human; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4