title: Evaluation of cerebral perfusion parameters measured by perfusion CT in chronic cerebral ischemia: comparison with xenon CT.
abstract: OBJECTIVE
  The purpose of this work was to evaluate the usefulness of perfusion CT in the evaluation of patients with chronic cerebral ischemia by comparing it with xenon CT (Xe-CT).
  
  
  METHODS
  Cerebral blood flow (CBF) of perfusion CT (CBFper) and time to peak (TTP) were compared with the CBF of Xe-CT (CBFxe) in 18 patients. Cerebral blood volume (CBV) was compared with cerebral vascular reserve (CVR) in 10 of 18 patients who underwent pre- and postacetazolamide Xe-CT.
  
  
  RESULTS
  CBFper and TTP demonstrated a high correlation with CBFxe in relative values by side-to-side comparisons (r = 0.743, p < 0.0001 and r = -0.760, p < 0.0001, respectively). There was a negative correlation between relative CBV and relative CVR (r = -0.637, p = 0.0025). Visually, territories with delayed TTP corresponded well to those of decreased CBFxe, but these territories tended to be larger in TTP maps.
  
  
  CONCLUSIONS
  Perfusion CT is a useful tool to evaluate chronic hemodynamic disturbance and can be an alternative method for those using acetazolamide challenge.
authors.affiliation: Department of Radiology, Yamaguchi University School of Medicine, Yamaguchi, Japan. matakazu@fg7.so-net.ne.jp
authors.forename: Matakazu
authors.initials: M
authors.lastname: Furukawa
authors.forename: Shiro
authors.initials: S
authors.lastname: Kashiwagi
authors.forename: Naofumi
authors.initials: N
authors.lastname: Matsunaga
authors.forename: Michiyasu
authors.initials: M
authors.lastname: Suzuki
authors.forename: Keiko
authors.initials: K
authors.lastname: Kishimoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shirao
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000473:pathology*; D002540:Cerebral Cortex / Q000098:blood supply* / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014978:Xenon
chemical_list: D014978:Xenon