title: Activity coefficients of antibiotics in aqueous NaCl solutions at 298.2 K.
abstract: Data at 298.2 K for aqueous NaCl solutions containing either D-phenylglycin, D-(p-hydroxy)phenylglycine, 6-amino penicillanic acid (6-APA), amoxicillin or ampicillin, are reported. The mean ionic activity coefficients of NaCl were determined from measurements of the responses of a sodium and a chloride ion-selective electrode. The activity coefficients of the precursors or the antibiotics were calculated from the values of the mean ionic activity coefficients using the exact cross differential relation between them. The correlation of solubility data using the activity coefficients measured in this work shows the same puzzling results previously observed in systems containing amino acids.
authors.affiliation: Dept. of Chemical Engineering, McGill University, Montreal, H3A 2B2, Quebec, Canada.
authors.forename: Jan M
authors.initials: JM
authors.lastname: Hamelink
authors.forename: E Susanne J
authors.initials: ES
authors.lastname: Rudolph
authors.forename: Luuk A M
authors.initials: LA
authors.lastname: van der Wielen
authors.forename: Juan H
authors.initials: JH
authors.lastname: Vera
mesh_terms: D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002138:Calibration; D004563:Electrochemistry; D008962:Models, Theoretical; D019999:Pharmaceutical Solutions; D012965:Sodium Chloride; D012995:Solubility; D013816:Thermodynamics
chemical_list: D000900:Anti-Bacterial Agents; D019999:Pharmaceutical Solutions; D012965:Sodium Chloride