Dietary polyunsaturated fatty acids: impact on cancer chemotherapy and radiation.
Preclinical studies have shown that certain polyunsaturated fatty acids may actually enhance the cytotoxicity of several antineoplastic agents and the anticancer effects of radiotherapy. These effects are possibly mediated by incorporation of the polyunsaturated fatty acids into cancer cell membranes, thus altering the physical and functional properties. In addition, certain polyunsaturated fatty acids may also reduce or prevent some of the side effects of these therapies, and administering antioxidants to prevent polyunsaturated fatty acid-induced oxidative stress may further enhance the impact of chemotherapy and radiation.
Conklin
Kenneth A
KA
Department of Anesthesiology, UCLA School of Medicine, Center for the Health Sciences, Box 951778, Los Angeles, CA 90095-1778, USA. kconklin@mednet.ucla.edu
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002453:Cell Cycle / Q000187:drug effects; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D004357:Drug Synergism; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D004042:Dietary Fats, Unsaturated; D005231:Fatty Acids, Unsaturated; D017382:Reactive Oxygen Species