Cerebral malaria: the contribution of studies in animal models to our understanding of immunopathogenesis.
Cerebral malaria is a serious and often fatal complication of Plasmodium falciparum infections. The precise mechanisms involved in the onset of neuropathology remain unknown, but parasite sequestration in the brain, metabolic disturbances and host immune responses are all thought to be involved. This review outlines the current state of knowledge of cerebral disease in humans, and discusses the contribution of studies of animal models to elucidation of the underlying mechanisms.
de Souza
J Brian
JB
Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, Royal Free and University College London Medical School, 46 Cleveland Street, London W1T 4JF, UK. Brian.deSouza@lshtm.ac.uk
Riley
Eleanor M
EM
D000818:Animals; D004195:Disease Models, Animal; D000882:Haplorhini; D006801:Humans; D007378:Interleukins / Q000096:biosynthesis; D016779:Malaria, Cerebral / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D051379:Mice; D010963:Plasmodium falciparum / Q000254:growth & development / Q000472:pathogenicity; D013601:T-Lymphocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha