title: Rare sesquiterpenes from the algicolous fungus Drechslera dematioidea.
abstract: From the inner tissue of the marine red alga Liagora viscida the fungus Drechslera dematioidea was isolated. After mass cultivation, the fungus was investigated for its secondary metabolite content, and 10 new sesquiterpenoids [isosativenetriol (1), drechslerines A (2) and B (3), 9-hydroxyhelminthosporol (5), drechslerines C-G (6-10), and sativene epoxide (12)] were isolated. Compounds 8 and 10 exhibited antiplasmodial activity against Plasmodium falciparum strains K1 and NF54. The known compounds helminthosporol (4), cis-sativenediol (11), isocochlioquinone A (14), isocochlioquinone C (15), and cochlioquinone B (16) were also isolated. All structures were elucidated using spectroscopic methods, mainly 1D and 2D NMR and MS.
authors.affiliation: Institute for Pharmaceutical Biology, Technical University of Braunschweig, Mendelssohnstrasse 1, 38106 Braunschweig, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Osterhage
authors.forename: Gabriele M
authors.initials: GM
authors.lastname: König
authors.forename: Ulrich
authors.initials: U
authors.lastname: Höller
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Wright
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D001410:Bacillus megaterium / Q000187:drug effects; D017173:Caenorhabditis elegans / Q000187:drug effects; D000460:Chlorophyta / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D006375:Helminthosporium / Q000737:chemistry*; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000378:metabolism; D013058:Mass Spectrometry; D008522:Mediterranean Sea; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000187:drug effects; D000461:Rhodophyta; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000962:Antimalarials; D004791:Enzyme Inhibitors; D012717:Sesquiterpenes; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)