title: Tamoxifen and toremifene impair retrieval, but not acquisition, of spatial information processing in mice.
abstract: The present study examines the effects of tamoxifen (TAM) or toremifene (TOR), two triphenylethylene antiestrogen agents, on spatial information in mice by using Morris water maze. In a 30-s free swim trial, the TAM- or TOR-treated mice (intraperitoneally, 30 min before test) spent shorter time than the blank control mice in target quadrant. Compared to saline control group, animals exposed to TAM (1-10 mg/kg i.p., once a day for 5 days) or TOR (3-30 mg/kg i.p., once a day for 5 days) did not show significant difference on the acquisition of place task in Morris water maze. These results suggest that TAM, at the doses of 1-10 mg/kg, and TOR, at the doses of 3-30 mg/kg, impair the retrieval, but not the acquisition, of spatial information task in Morris water maze. It seems, however, that TOR is more potent than TAM on impairing memory retrieval.
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110015, China.
authors.forename: Duo
authors.initials: D
authors.lastname: Chen
authors.forename: Chun-Fu
authors.initials: CF
authors.lastname: Wu
authors.forename: Bin
authors.initials: B
authors.lastname: Shi
authors.forename: Yong-Meng
authors.initials: YM
authors.lastname: Xu
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D011939:Mental Recall / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D013037:Spatial Behavior / Q000187:drug effects* / Q000502:physiology; D013629:Tamoxifen / Q000494:pharmacology*; D017312:Toremifene / Q000494:pharmacology*
chemical_list: D013629:Tamoxifen; D017312:Toremifene