Scaling down imaging: molecular mapping of cancer in mice.
The development of miniaturized imaging equipment and reporter probes has improved our ability to study animal models of disease, such as transgenic and knockout mice. These technologies can now be used to continuously monitor in vivo tumour development, the effects of therapeutics on individual populations of cells, or even specific molecules. If these techniques prove effective in mice, they might be translated into the clinic in the future, where they could be used to non-invasively detect and monitor treatment of human cancers.
Weissleder
Ralph
R
Harvard Medical School, Center for Molecular Imaging Research, Massachusetts General Hospital, Boston 02129, USA. weissleder@helix.mgh.harvard.edu
D000818:Animals; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D005470:Fluorometry / Q000295:instrumentation / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008163:Luminescent Measurements; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D051379:Mice / Q000033:anatomy & histology* / Q000378:metabolism; D018345:Mice, Knockout; D008822:Mice, Transgenic; D018613:Microscopy, Confocal / Q000379:methods; D008904:Miniaturization; D036103:Nanotechnology; D009363:Neoplasm Proteins / Q000032:analysis; D009374:Neoplasms, Experimental / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D014055:Tomography, Emission-Computed / Q000295:instrumentation / Q000379:methods; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods
D009363:Neoplasm Proteins