title: Polymer-supported O-methylisourea: a new reagent for the O-methylation of carboxylic acids.
abstract: [reaction: see text] A solid-supported O-methylisourea reagent has been prepared in one step starting from commercially available solid-supported carbodiimide. The isourea reagent has been successfully used for the preparation of methyl esters from the corresponding carboxylic acids. The crude products obtained after resin filtration and solvent evaporation are generally obtained in >98% purity.
authors.affiliation: Combinatorial Centre of Excellence, Chemistry Department, University of Southampton, Southampton, SO17 1BJ, United Kingdom.
authors.forename: Stefano
authors.initials: S
authors.lastname: Crosignani
authors.forename: Peter D
authors.initials: PD
authors.lastname: White
authors.forename: Bruno
authors.initials: B
authors.lastname: Linclau