title: Effects of isopropyl unoprostone, latanoprost, and prostaglandin E(2) on acute rise of aqueous flare in pigmented rabbits.
abstract: OBJECTIVE
  To evaluate the effect of isopropyl unoprostone, latanoprost, and prostaglandin E(2) (PGE(2)) on aqueous flare elevation.
  
  
  METHODS
  Isopropyl unoprostone (0.12%) or latanoprost (0.005%) was topically instilled. Transcorneal diffusion of PGE(2), 25 microg/ml, using a glass cylinder, was achieved in pigmented rabbits. Aqueous flare was measured with a laser flare cell meter.
  
  
  RESULTS
  Topical instillation of isopropyl unoprostone induced aqueous flare elevation in rabbit eyes. Also, topical isopropyl unoprostone additionally induced aqueous flare elevation in eyes with transcorneal diffusion of PGE(2). Latanoprost did not induce flare elevation.
  
  
  CONCLUSIONS
  Isopropyl unoprostone induced aqueous flare elevation in rabbits, and latanoprost did not produce aqueous flare elevation.
authors.affiliation: Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan.
authors.forename: Xue-Yun
authors.initials: XY
authors.lastname: Zhang
authors.forename: Seiji
authors.initials: S
authors.lastname: Hayasaka
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Hayasaka
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Yanagisawa
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Nagaki
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001082:Aqueous Humor / Q000187:drug effects* / Q000378:metabolism; D018916:Blood-Aqueous Barrier; D015237:Dinoprost / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D015232:Dinoprostone / Q000008:administration & dosage*; D007429:Intraocular Pressure; D000077338:Latanoprost; D008297:Male; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*; D011817:Rabbits; D014606:Uveitis, Anterior / Q000139:chemically induced*
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; C072630:isopropyl unoprostone; D000077338:Latanoprost; D015237:Dinoprost; D015232:Dinoprostone