title: Estimating the potential health gain and cost consequences of introducing a pre-school DTPa pertussis booster into the UK child vaccination schedule.
abstract: This work estimates the health and cost impacts of a pre-school booster vaccination for Bordetella pertussis, when added to existing UK primary vaccination. A transition state simulation model of pertussis infection in a closed population was constructed comprising of susceptible, infected and immune population sub-groups, across eight age bands. Epidemiological, service use and cost data were sourced from routine statistics, published literature and clinician estimates. The introduction of a pre-school booster is predicted to reduce the number of hospitalisations by approximately 1400 and pertussis cases suffered by up to 28,000 at a net investment of under 13 million pounds over a 5-year period.
authors.affiliation: School of Health and Related Research, University of Sheffield, 30 Regent Street, Sheffield, South Yorkshire S1 4DA, UK. m.d.stevenson@shef.ac.uk
authors.forename: Matt
authors.initials: M
authors.lastname: Stevenson
authors.forename: Stephen
authors.initials: S
authors.lastname: Beard
authors.forename: Adam
authors.initials: A
authors.lastname: Finn
authors.forename: Alan
authors.initials: A
authors.lastname: Brennan
mesh_terms: D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage* / Q000191:economics*; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D018803:Models, Economic; D006113:United Kingdom / Q000453:epidemiology; D014917:Whooping Cough / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission
chemical_list: D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines