Notch cleavage: Nicastrin helps Presenilin make the final cut.
Presenilin is thought to be the proteolytic component of gamma-secretase, responsible for the intramembranous cleavage of substrates that include the activated Notch receptor. Recent studies have identified the novel protein Nicastrin as another essential component of the Presenilin/gamma-secretase complex.
Lai
Eric C
EC
University of California, Department of Molecular and Cell Biology, Berkeley 94720-3200, USA. lai@fruitfly.bdgp.berkeley.edu
D053829:Amyloid Precursor Protein Secretases; D000818:Animals; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D053764:Presenilin-1; D051880:Receptors, Notch
D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1; D051880:Receptors, Notch; C413604:nicastrin protein; D053829:Amyloid Precursor Protein Secretases