title: Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
abstract: From a marine-derived strain of the fungus Emericella variecolor, varitriol (1), varioxirane (2), dihydroterrein (3), and varixanthone (4), besides the known mold metabolites ergosterol, terrein, shamixanthone, and tajixanthone hydrate, were identified. The chemical structures of 1-4 were established by means of spectroscopic techniques and some chemical transformations. In the NCI's 60-cell panel, varitriol (1) displayed increased potency toward selected renal, CNS, and breast cancer cell lines. Varixanthone (4) showed antimicrobial activity.
authors.affiliation: Marine Chemistry Section, Department of Chemistry, University of Copenhagen, Denmark.
authors.forename: Joan
authors.initials: J
authors.lastname: Malmstrøm
authors.forename: Carsten
authors.initials: C
authors.lastname: Christophersen
authors.forename: Alejandro F
authors.initials: AF
authors.lastname: Barrero
authors.forename: J Enrique
authors.initials: JE
authors.lastname: Oltra
authors.forename: José
authors.initials: J
authors.lastname: Justicia
authors.forename: Antonio
authors.initials: A
authors.lastname: Rosales
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001592:Benzyl Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001943:Breast Neoplasms; D017691:Caribbean Region; D016543:Central Nervous System Neoplasms; D003110:Colonic Neoplasms; D003517:Cyclopentanes; D004354:Drug Screening Assays, Antitumor; D004875:Ergosterol; D005260:Female; D005658:Fungi / Q000737:chemistry* / Q000187:drug effects; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007680:Kidney Neoplasms; D007941:Leukemia P388; D008175:Lung Neoplasms; D008297:Male; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera; D011471:Prostatic Neoplasms; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044004:Xanthones
chemical_list: D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D001592:Benzyl Alcohols; D003517:Cyclopentanes; D005663:Furans; D014966:Xanthenes; D044004:Xanthones; C456049:dihydroterrein; C456048:varioxirane; C456047:varitriol; C456050:varixanthone; C439087:terrein; C009689:xanthone; D004875:Ergosterol