Independent variation in susceptibilities of six different mouse strains to induction of pepsinogen-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosourea.
Strain differences in susceptibility regarding stomach carcinogenesis due to N-methyl-N-nitrosourea were examined in males of six strains of mice: BALB/cA (BALB), C57BL/6N (C57BL6), CBA/JN (CBA), C3H/HeN (C3H), DBA/2N (DBA/2), and CD-1 (ICR). The frequency of pepsinogen-altered pyloric glands (PAPGs), putative precancerous lesions, was highest (19.6+/-9.9%) in the BALB and lowest in the ICR (12.3+/-5.7%) mice (P<0.05). Incidences of adenocarcinomas at week 52 were 59.3% (16 of 27) and 18.5% (5 of 27), respectively (P<0.005). Invasion also tended to be deepest in BALB compared with the other strains. Intestinal alkaline phosphatase-positive intestinal type cells were observed heterogeneously in some hyperplasias, adenomas and adenocarcinomas consisting of gastric type cells. Thus, intestinalization appeared to occur at random in both non-neoplastic and monoclonal neoplastic lesions, making it unlikely that IAP-positive cells could be precursors of gastric tumors. In contrast, the data suggest a direct histogenetic role for the PAPG, a useful preneoplastic marker lesion in mouse strains.
Yamamoto
Masami
M
Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Japan.
Furihata
Chie
C
Ogiu
Toshiaki
T
Tsukamoto
Tetsuya
T
Inada
Ken ichi
Ki
Hirano
Kazuyuki
K
Tatematsu
Masae
M
D000230:Adenocarcinoma / Q000139:chemically induced / Q000401:mortality / Q000473:pathology; D000236:Adenoma / Q000139:chemically induced / Q000401:mortality / Q000473:pathology; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004198:Disease Susceptibility; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000737:chemistry / Q000187:drug effects / Q000473:pathology*; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008813:Mice, Inbred ICR; D020116:Pepsinogen A / Q000378:metabolism*; D011230:Precancerous Conditions / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D011708:Pylorus / Q000378:metabolism / Q000473:pathology; D013045:Species Specificity; D013270:Stomach / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate
D008769:Methylnitronitrosoguanidine; D020116:Pepsinogen A; D000469:Alkaline Phosphatase