title: Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum.
abstract: Six new xanthones, cratoxyarborenones A-F (1-6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and delta-tocotrienol, were obtained as inactive constituents.
authors.affiliation: Chemistry and Life Sciences Group, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709, USA.
authors.forename: Eun-Kyoung
authors.initials: EK
authors.lastname: Seo
authors.forename: Nam-Cheol
authors.initials: NC
authors.lastname: Kim
authors.forename: Mansukh C
authors.initials: MC
authors.lastname: Wani
authors.forename: Monroe E
authors.initials: ME
authors.lastname: Wall
authors.forename: Hernán A
authors.initials: HA
authors.lastname: Navarro
authors.forename: Jason P
authors.initials: JP
authors.lastname: Burgess
authors.forename: Kazuko
authors.initials: K
authors.lastname: Kawanishi
authors.forename: Leonardus B S
authors.initials: LB
authors.lastname: Kardono
authors.forename: Soedarsono
authors.initials: S
authors.lastname: Riswan
authors.forename: William C
authors.initials: WC
authors.lastname: Rose
authors.forename: Craig R
authors.initials: CR
authors.lastname: Fairchild
authors.forename: Norman R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000818:Animals; D000873:Anthracenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007214:Indonesia; D007624:KB Cells / Q000187:drug effects; D007941:Leukemia P388; D051379:Mice; D008811:Mice, Inbred DBA; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification*; D044004:Xanthones
chemical_list: C455299:2,4,6-trihydroxybenzophenone 4-O-geranyl ether; D000873:Anthracenes; D000880:Anthraquinones; D001577:Benzophenones; D014966:Xanthenes; D044004:Xanthones; C455129:cratoxyarborequinone A; C455130:cratoxyarborequinone B; C455128:vismione B; D014810:Vitamin E; C082097:tocotrienol, delta; C009689:xanthone