title: [Papular acantholytic dyskeratosis].
abstract: Papular acantholytic dyskeratosis is a very rare skin disease, which shows a suprabasilar cleft with acantholytic and dyskeratotic cells, simulating the light microscopic picture of Darier disease. In this condition, the lesions are acquired without a genetic basis. We observed a 40-year-old woman with about 200 papules on the lower aspects of her legs; histological examination showed changes similar to Darier disease. Transmission electron microscopy showed a reduced number of desmosomes and perinuclear distribution of tonofilaments. The lesions were successfully treated with cryotherapy with spray technique.
authors.affiliation: Medizinische Fakultät der Bundesuniversität Pelotas, Av. Duque de Caxias 250, 96.030-002 Pelotas RS Brasilien. hiramalmeidajr@hotmail.com
authors.forename: H L
authors.initials: HL
authors.lastname: de Almeida Júnior
authors.forename: M
authors.initials: M
authors.lastname: Wolter
authors.forename: L A
authors.initials: LA
authors.lastname: Castro
authors.forename: N E
authors.initials: NE
authors.lastname: Rocha
mesh_terms: D000051:Acantholysis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D000328:Adult; D017679:Cryotherapy; D007644:Darier Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008854:Microscopy, Electron; D012867:Skin / Q000473:pathology