title: Vaccine safety--vaccine benefits: science and the public's perception.
abstract: The development of cowpox vaccination by Jenner led to the development of immunology as a scientific discipline. The subsequent eradication of smallpox and the remarkable effects of other vaccines are among the most important contributions of biomedical science to human health. Today, the need for new vaccines has never been greater. However, in developed countries, the public's fear of vaccine-preventable diseases has waned, and awareness of potential adverse effects has increased, which is threatening vaccine acceptance. To further the control of disease by vaccination, we must develop safe and effective new vaccines to combat infectious diseases, and address the public's concerns.
authors.affiliation: Department of Immunology, University of Washington School of Medicine, Children's Hospital and Regional Medical Center, Seattle 98195, USA. cbwilson@u.washington.edu
authors.forename: C B
authors.initials: CB
authors.lastname: Wilson
authors.forename: E K
authors.initials: EK
authors.lastname: Marcuse
mesh_terms: D006801:Humans; D010567:Pertussis Vaccine / Q000009:adverse effects / Q000494:pharmacology; D023321:Poliovirus Vaccines / Q000009:adverse effects / Q000494:pharmacology; D011639:Public Opinion; D012307:Risk Factors; D012449:Safety; D014612:Vaccines / Q000009:adverse effects* / Q000494:pharmacology*; D014917:Whooping Cough / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D010567:Pertussis Vaccine; D023321:Poliovirus Vaccines; D014612:Vaccines