title: Systemic administration of 1R,4S-4-amino-cyclopent-2-ene-carboxylic acid, a reversible inhibitor of GABA transaminase, blocks expression of conditioned place preference to cocaine and nicotine in rats.
abstract: We examined the effect of 1R,4S-4-amino-cyclopent-2-ene-carboxylic acid (ACC), a reversible inhibitor of GABA transaminase, on the expression of conditioned place preference response to cocaine and nicotine in rats. Cocaine (20 mg/kg i.p.) and nicotine (0.4 mg/kg s.c.), but not vehicle or 300 mg/kg i.p. of ACC, produced a significant conditioned place preference response. Pretreatment of animals with 300 and 75 mg/kg i.p. of ACC significantly attenuated the expression of the cocaine- and nicotine-induced conditioned place preference responses, respectively. These results are the first to suggest that reversible inhibition of GABA transaminase may be useful in blocking cue-induced relapse to nicotine and cocaine.
authors.affiliation: Department of Pharmaceutical Sciences, St. John's University, Jamaica, Queens, New York 11439, USA. Crashby@ix.netcom.com
authors.forename: Charles R
authors.initials: CR
authors.lastname: Ashby
authors.forename: Mousumi
authors.initials: M
authors.lastname: Paul
authors.forename: Eliot L
authors.initials: EL
authors.lastname: Gardner
authors.forename: Madina R
authors.initials: MR
authors.lastname: Gerasimov
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Dewey
authors.forename: Ian C
authors.initials: IC
authors.lastname: Lennon
authors.forename: Stephen J C
authors.initials: SJ
authors.lastname: Taylor
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000818:Animals; D003042:Cocaine / Q000037:antagonists & inhibitors*; D003216:Conditioning, Operant / Q000187:drug effects*; D003517:Cyclopentanes / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D009538:Nicotine / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C454079:4-amino-cyclopent-2-ene-carboxylic acid; D003517:Cyclopentanes; D009538:Nicotine; D000612:4-Aminobutyrate Transaminase; D003042:Cocaine