Mechanisms of pathogenesis in herpetic immunoinflammatory ocular lesions.
This article reviews possible mechanisms by which ocular infections with herpes simplex virus result in a blinding immunoinflammatory lesion in the cornea. We conclude that this immunoinflammatory response involves multiple immune mechanisms including autoimmunity.
Deshpande
Shilpa P
SP
Department of Microbiology, University of Tennessee, M409, Walter Life Sciences Building, Knoxville, TN 37996-0845, USA.
Zheng
Mei
M
Lee
Sujin
S
Rouse
Barry T
BT
D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D006801:Humans; D016849:Keratitis, Herpetic / Q000276:immunology* / Q000473:pathology / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D008822:Mice, Transgenic; D018139:Simplexvirus / Q000276:immunology* / Q000472:pathogenicity