title: Physiological and hematological effects of chronic irradiation.
abstract: The information available for assessing radiation hazard involved in prolonged space missions is so far insufficient. Therefore, a three-year experiment was carried out in which 180 dogs were exposed to irradiation, simulating the dose value and rate of exposure that may occur in a real space flight of long duration. The exposure included a chronic irradiation (with dose rates of 21, 62 and 125 rads/year) and a combined irradiation during which the animals were exposed to chronic and acute irradiations with a dose of 8 or 42 rads applied three times every year, the annual total dose being 120 or 188 rads, respectively. Insignificant hematopoietic changes, e.g. the ratio of red to white blood cells, their decrease in the peripheral blood, were found. Distinct changes in the reproductive function were noted. The general condition of the animals was satisfactory. Most animals endured well an additional physical load and retained conditioned reflexes developed before irradiation. The experimental findings suggest that the effects are early symptoms of the first stage of chronic radiation damage.
authors.affiliation: Institute of Medical and Biological Problems, Moscow, USSR.
authors.forename: Y G
authors.initials: YG
authors.lastname: Grigoryev
authors.forename: B A
authors.initials: BA
authors.lastname: Markelov
authors.forename: V I
authors.initials: VI
authors.lastname: Popov
authors.forename: A A
authors.initials: AA
authors.lastname: Akhunov
authors.forename: T P
authors.initials: TP
authors.lastname: Tsessarskaya
authors.forename: A V
authors.initials: AV
authors.lastname: Ilyukhin
authors.forename: N L
authors.initials: NL
authors.lastname: Fyodorova
authors.forename: T E
authors.initials: TE
authors.lastname: Burkovskaya
authors.forename: A V
authors.initials: AV
authors.lastname: Shafirkin
mesh_terms: D000818:Animals; D003359:Cosmic Radiation; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D006410:Hematopoiesis / Q000528:radiation effects*; D019891:Leukopoiesis / Q000528:radiation effects*; D008297:Male; D011829:Radiation Dosage; D012018:Reflex / Q000528:radiation effects; D012098:Reproduction / Q000528:radiation effects*; D019445:Solar Activity; D013091:Spermatogenesis / Q000528:radiation effects; D013094:Spermatozoa / Q000528:radiation effects