First and unexpected synthesis of macrocyclic cyclophane-based unusual alpha-amino acid derivatives by phosphazene base without high dilution conditions.
First synthesis of a macrocylic cyclophane-based unusual alpha-amino acid derivative 11 by coupling of ethyl isocyanoacetate with 1,2-bis(4-bromomethylphenyl)ethane under phase-transfer catalysis (PTC) conditions. Phosphazene base such as 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine (BEMP) is useful to improve the yield of cyclophane derivative without high dilution conditions.
Kotha
Sambasivarao
S
Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai 400 076, India. srk@chem.iitb.ac.in
Halder
Somnath
S
Damodharan
Lakshminarasimhan
L
Pattabhi
Vasantha
V
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004988:Ethers, Cyclic / Q000737:chemistry*; D007201:Indicator Dilution Techniques; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry
D000596:Amino Acids; D004988:Ethers, Cyclic; D009943:Organophosphorus Compounds; D010455:Peptides