The periviscerokinin (PVK) peptide family in insects: evidence for the inclusion of CAP(2b) as a PVK family member.
Periviscerokinins (PVKs) are a distinct insect peptide family with unusual distribution in the central nervous system and neurohemal release sites. PVKs were first isolated from the abdominal perisympathetic organs of Periplaneta americana, but can be found in other insect species. Peptides with structural similarity to PVKs have been identified through searches of the Drosophila genome. The cardioacceleratory peptide CAP(2b) of the hawkmoth Manduca sexta shares close amino acid identity with the PVKs and may thus be included as a structural member of the PVK peptide family. In this review, we provide support for grouping CAP(2b) as a PVK family member based on published sequences, and new immunocytochemical findings and mass spectrometric data.
Wegener
Christian
C
Institut für Allgemeine Zoologie und Tierphysiologie, Friedrich-Schiller-Universität, Erbertstr.1, D-07743, Jena, Germany. christian.wegener@zoologi.su.se
Herbert
Zsófia
Z
Eckert
Manfred
M
Predel
Reinhard
R
D000818:Animals; D004331:Drosophila melanogaster; D005724:Ganglia / Q000166:cytology; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D018402:Manduca / Q000235:genetics / Q000378:metabolism; D005810:Multigene Family; D009474:Neurons / Q000166:cytology; D009479:Neuropeptides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D009842:Oligopeptides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D010526:Periplaneta / Q000033:anatomy & histology / Q000235:genetics / Q000378:metabolism; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives
D019476:Insect Proteins; D009479:Neuropeptides; D009842:Oligopeptides; C095817:cardioacceleratory peptide 2b; C093061:periviscerokinin; D011761:Pyrrolidonecarboxylic Acid