Pharmacokinetics of ethanol: a review of the methodology.
This paper reviews current concepts on tools for studying the pharmacokinetics of alcohol. It has been known that ethanol metabolism occurs mainly in the liver via alcohol dehydrogenase and an accessory microsomal pathway. The contribution of each pathway has been examined by administration of metabolic inhibitors. The role of gastric alcohol dehydrogenase in the first-pass effects of ethanol has been speculative and may be relatively low. Some pharmacokinetic approaches with mathematical models have elucidated the role of gastric alcohol dehydorgenase, hepatic alcohol dehydrogenase and cytochrome P450 2E1 in ethanol elimination. The scale-up of ethanol elimination kinetics has enabled extrapolation from animal models to human kinetics. The clarification of the pharmacokinetics of ethanol is very important for estimating the effects of ethanol on biological events.
Matsumoto
Hiroshi
H
Department of Legal Medicine, Kyoto University Faculty of Medicine, Kyoto 606-8501, Japan. hmatsimo@sapmed.ac.jp
Fukui
Yuko
Y
D000426:Alcohol Dehydrogenase / Q000502:physiology; D000818:Animals; D019392:Cytochrome P-450 CYP2E1 / Q000502:physiology; D000431:Ethanol / Q000493:pharmacokinetics*; D006801:Humans; D008657:Metabolic Clearance Rate / Q000502:physiology; D008862:Microsomes, Liver / Q000201:enzymology; D008962:Models, Theoretical; D051381:Rats; D013045:Species Specificity; D013270:Stomach / Q000201:enzymology
D000431:Ethanol; D000426:Alcohol Dehydrogenase; D019392:Cytochrome P-450 CYP2E1