title: Expression of cyclic adenosine monophosphate response-element binding protein in acute leukemia.
abstract: Cyclic adenosine monophosphate response-element binding protein (CREB) is a nuclear protein that regulates expression of genes that control cell proliferation, differentiation, and survival. To analyze CREB expression in leukemia cells, we conducted Western blot analysis of bone marrow cells obtained from patients with acute lymphoblastic leukemia, patients with acute myeloid leukemia, and patients without active leukemia. CREB was expressed at a higher frequency in bone marrow cells from patients with acute lymphoid or myeloid leukemia than in patients with leukemia remission or without leukemia. Our results indicate that CREB expression could be a useful marker for leukemia in patients with acute disease and suggest a role for CREB in leukemogenesis.
authors.affiliation: Department of Pediatrics, Division of Hematology-Oncology, Gwynne-Hazen Cherry Memorial Laboratories, University of California Los Angeles (UCLA), Los Angeles, CA 90095-2752, USA.
authors.forename: Heather N
authors.initials: HN
authors.lastname: Crans-Vargas
authors.forename: Elliot M
authors.initials: EM
authors.lastname: Landaw
authors.forename: Smita
authors.initials: S
authors.lastname: Bhatia
authors.forename: George
authors.initials: G
authors.lastname: Sandusky
authors.forename: Theodore B
authors.initials: TB
authors.lastname: Moore
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Sakamoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015153:Blotting, Western; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism* / Q000473:pathology; D012016:Reference Values
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein