Gastroduodenal adenocarcinomas and rectal adenoma in a cougar (Felis concolor) infected with Helicobacter-like organisms and spirochetes.
A 14-year-old female cougar died from gastroduodenal adenocarcinomas and rectal adenoma. At necropsy, polypoid tumor masses of various sizes were scattered on the mucosal surfaces of the stomach, duodenum, and rectum. Histologically, the gastric tumor was diagnosed as an intestinal type adenocarcinoma and the tumor cells metastasized to the mesenteric lymph nodes, spleen, and lung. Helicobacter-like organisms were detected in the lumina lined by foveolar epithelium. In the duodenum, the carcinoma cells were localized in the limina propria and many of them were intensely positive for proliferating cell nuclear antigen (PCNA). In contrast, the rectal adenoma had a lower number of PCNA-positive cells. In the rectum, chronic inflammation with numerous spirochetes was also noted. These results indicated that the occurrence of the gastrointestinal tumors might be associated with the bacterial infection described above.
Yamazaki
Yoshikazu
Y
Ehime Chuo Livestock Hygiene Service Center, Masaki, Iyo, Japan.
Aono
Itsushi
I
Ohya
Tatsuo
T
Shibahara
Tomoyuki
T
Kadota
Koichi
K
D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology / Q000556:secondary / Q000662:veterinary; D000236:Adenoma / Q000150:complications / Q000473:pathology / Q000662:veterinary; D000818:Animals; D002335:Carnivora; D004379:Duodenal Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D005260:Female; D016998:Helicobacter / Q000302:isolation & purification; D016481:Helicobacter Infections / Q000150:complications / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000473:pathology / Q000662:veterinary; D012004:Rectal Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D013144:Spirochaetales / Q000302:isolation & purification; D013145:Spirochaetales Infections / Q000150:complications / Q000662:veterinary*; D013160:Splenic Neoplasms / Q000556:secondary; D013274:Stomach Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*