Pharmacological aspects of ipecac syrup (TJN-119)-induced emesis in ferrets.
In order to elucidate the precise mechanism of ipecac syrup (TJN-119) on the occurrence of vomiting, we examined the effects of ipecac syrup on the abdominal afferent nerve activity as well as on the 5-HT levels of the ileum and area postrema in ferrets. Oral administration of TJN-119 (0.5 mg/kg) produced a significant increase in afferent abdominal vagus nerve activity which lasted approximately 1 hour. The maximum response induced by TJN-119 was estimated to be 219 +/- 18% of the pre-injection level. Cephaeline or emetine, the main alkaloids of ipecac syrup, also demonstrated similar effects on afferent vagus nerve activity. TJN-119 increased the 5-HT content in the ileum but not in the area postrema. These observations illustrate possible mechanisms that may act at peripheral sites. It was recently reported that TJN-119 has a high affinity to 5-HT4 receptors (Hasegawa et al., unpublished data). These results suggest that 5-HT4 receptors may be involved in the emetic action of TJN-119.
Endo
T
T
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan.
Nemoto
M
M
Ogawa
T
T
Tamakai
H
H
Hamaue
N
N
Hirafuji
M
M
Takeda
Y
Y
Hasegawa
M
M
Fugii
Y
Y
Minami
M
M
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D004639:Emetics / Q000494:pharmacology*; D004640:Emetine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005289:Ferrets; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007082:Ileum / Q000187:drug effects / Q000378:metabolism; D007486:Ipecac / Q000494:pharmacology*; D008526:Medulla Oblongata / Q000187:drug effects / Q000503:physiopathology; D008954:Models, Biological; D012701:Serotonin / Q000378:metabolism; D014630:Vagus Nerve / Q000187:drug effects; D014839:Vomiting / Q000139:chemically induced* / Q000209:etiology / Q000503:physiopathology
D004639:Emetics; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D007486:Ipecac; C005963:cephaelin; D004640:Emetine