Biocompatibility of electrochemically activated aqueous solutions: an animal study.
The purpose of the study was to evaluate the biocompatibility of electrochemically activated aqueous solutions on experimental animals. Nine rabbits were subjected to acute eye irritation/corrosion tests, nine rabbits to acute dermal irritation/corrosion and 30 rats to acute oral toxicity (LD50) tests. No significant negative effects were noted. Considering the relatively high levels of exposure of the animals to the solutions and the low levels in the anticipated real clinical situation it is argued that these solutions are indeed biocompatible.
Marais
J T
JT
Department of Restorative Dentistry, Faculty of Dentistry, University of Pretoria.
D000279:Administration, Cutaneous; D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D002057:Burns, Chemical / Q000145:classification; D003231:Conjunctivitis / Q000145:classification; D004202:Disinfectants / Q000633:toxicity*; D004563:Electrochemistry; D004890:Erythema / Q000145:classification; D005123:Eye / Q000187:drug effects; D005126:Eye Burns / Q000145:classification; D005260:Female; D006863:Hydrogen-Ion Concentration; D007441:Intubation, Gastrointestinal; D007509:Irritants / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D023421:Models, Animal; D011817:Rabbits; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects; D012965:Sodium Chloride / Q000737:chemistry
D001672:Biocompatible Materials; D004202:Disinfectants; D007509:Irritants; D012965:Sodium Chloride