title: Nasal NK-cell lymphoma followed by relapse in the uterine cervix.
abstract: We report a case of nasal natural killer (NK)-cell lymphoma in a 51-year-old Japanese woman who showed a later relapse in the uterine cervix. The nasal NK-cell lymphoma regressed after local radiation therapy. Six months after the diagnosis while the patient was being treated with chemotherapy for a subclinical tumor, a mass lesion of the uterine cervix was noticed by follow-up computed tomography. Giemsa-stained vaginal smear showed lymphoid tumor cells with large azurophilic granules, leading to a rapid diagnosis of cervical involvement by NK-cell lymphoma. The chemotherapy regimens were immediately changed, but the patient died 2 months after the relapse with an overall survival of 8 months. This case may be of value in elucidating the biological behavior and natural history of NK-cell lymphoma.
authors.affiliation: Department of Pathology, Nagoya City University Medical School, Nagoya, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Murase
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inagaki
authors.forename: Norio
authors.initials: N
authors.lastname: Takagi
authors.forename: Mitsukuni
authors.initials: M
authors.lastname: Okabe
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Eimoto
mesh_terms: D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007694:Killer Cells, Natural / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009669:Nose Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D012008:Recurrence; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*