title: Hypomagnesemic seizures: case report and presumed pathophysiology.
abstract: Hypomagnesemia has previously been recognized as an uncommon cause of seizures. The electrolyte abnormality is caused by poor gastrointestinal absorption or excessive renal wasting, both from a variety of causes. We report on a 5-week-old patient who developed hypomagnesemic seizures as a consequence of renal magnesium wasting. Although the exact pathophysiology of hypomagnesemic seizures remains uncertain, currently available information suggests that it is related to disinhibition of the N-methyl-D-aspartate-type glutamate receptor-sodium channel complex.
authors.affiliation: Division of Child Neurology, Children's Health Center and Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA.
authors.forename: Pedro
authors.initials: P
authors.lastname: Weisleder
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Tobin
authors.forename: John F
authors.initials: JF
authors.lastname: Kerrigan
authors.forename: John B
authors.initials: JB
authors.lastname: Bodensteiner
mesh_terms: D004829:Epilepsy, Generalized / Q000175:diagnosis / Q000209:etiology*; D004927:Escherichia coli Infections / Q000150:complications / Q000175:diagnosis; D006801:Humans; D006869:Hydronephrosis / Q000150:complications / Q000175:diagnosis; D007223:Infant; D008274:Magnesium / Q000652:urine; D008275:Magnesium Deficiency / Q000150:complications* / Q000175:diagnosis; D008297:Male; D014552:Urinary Tract Infections / Q000150:complications / Q000175:diagnosis; D014718:Vesico-Ureteral Reflux / Q000150:complications / Q000175:diagnosis
chemical_list: D008274:Magnesium