title: Ion transport proteins anchor and regulate the cytoskeleton.
abstract: Structurally diverse ion transport proteins anchor the spectrin-actin cytoskeleton to the plasma membrane by binding directly to linker proteins of the ankyrin and protein 4.1 families. Cytoskeletal anchoring regulates cell shape and restricts the activity of ion transport proteins to specialised membrane domains. New directions are being forged by recent findings that localised anchoring by ion transport proteins regulates the ordered assembly of actin filaments and the actin-dependent processes of cell adhesion and motility.
authors.affiliation: Department of Stomatology, University of California, San Francisco, CA 94143-0512, USA.
authors.forename: Sheryl P
authors.initials: SP
authors.lastname: Denker
authors.forename: Diane L
authors.initials: DL
authors.lastname: Barber
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D017487:Ankyrins / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D003598:Cytoskeletal Proteins; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D016623:Ion Pumps / Q000378:metabolism* / Q000502:physiology; D021962:Membrane Microdomains / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D009479:Neuropeptides; D011485:Protein Binding; D013049:Spectrin / Q000378:metabolism
chemical_list: D017487:Ankyrins; D003598:Cytoskeletal Proteins; D016623:Ion Pumps; D008565:Membrane Proteins; D009479:Neuropeptides; C028841:erythrocyte membrane band 4.1 protein; C120557:erythrocyte membrane protein band 4.1-like 1; D013049:Spectrin