Mouse and human dendritic cell subtypes.
Dendritic cells (DCs) collect and process antigens for presentation to T cells, but there are many variations on this basic theme. DCs differ in the regulatory signals they transmit, directing T cells to different types of immune response or to tolerance. Although many DC subtypes arise from separate developmental pathways, their development and function are modulated by exogenous factors. Therefore, we must study the dynamics of the DC network in response to microbial invasion. Despite the difficulty of comparing the DC systems of humans and mice, recent work has revealed much common ground.
Shortman
Ken
K
Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia. shortman@wehi.edu.au
Liu
Yong-Jun
YJ
D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000502:physiology; D003713:Dendritic Cells / Q000145:classification* / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance; D051379:Mice; D013234:Stem Cells / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology