title: Natural transformation in Helicobacter pylori: DNA transport in an unexpected way.
abstract: Like other bacterial species with a high frequency of inter-strain recombination, the human gastric pathogen Helicobacter pylori is competent for natural transformation. Recent data, however, indicate that its DNA-uptake system differs significantly from that in other species that contain DNA-uptake systems related to type IV pili. Instead, in H. pylori it has been suggested that the five proteins that form the transmembrane channel of the transformation system are closely related to subunits of type IV secretion systems.
authors.affiliation: Dept of Medical Microbiology and Infection Control, VU University Medical Center, PO box 7057, 1007 MB, Amsterdam, The Netherlands. LC.Smeets@vumc.nl
authors.forename: Leonard C
authors.initials: LC
authors.lastname: Smeets
authors.forename: Johannes G
authors.initials: JG
authors.lastname: Kusters
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D004269:DNA, Bacterial / Q000235:genetics* / Q000378:metabolism; D004268:DNA-Binding Proteins; D015964:Gene Expression Regulation, Bacterial; D016480:Helicobacter pylori / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology; D009876:Operon; D017386:Sequence Homology, Amino Acid; D014169:Transformation, Bacterial; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; C061261:comB protein, Haemophilus influenzae