Effects of anabolic implants of oestradiol alone or in combination with trenbolone acetate on the ultrastructure of mammary glands in female lambs regarding their interference in prolactin secretion.
The side-effects of anabolic steroid implants on mammary gland ultrastructure were evaluated in female lambs treated with oestradiol (n = 10) and with oestradiol plus trenbolone acetate (n = 10). Ten non-implanted lambs were used as controls. Apart from the ultrastructural study of the mammary gland, an assessment of the prolactin pituitary cell population was carried out by immunological methods. Our results showed that oestrogenic implants exert stimulating effects on mammary gland development, both by activating the synthesis process at mammary gland cell levels and by increasing prolactin pituitary production. Nevertheless, there was no evidence of secretory products in the lumen of the gland. Implants containing trenbolone acetate counteracted the mammary stimulus of oestrogens showing ultrastructural images of cell autolysis and necrosis.
Blanco
A
A
Department of Comparative Anatomy and Pathological Anatomy, Veterinary Faculty, University of Cordoba, Spain.
Moya
L
L
Flores
R
R
Agüera
E
E
Monterde
J G
JG
D045930:Anabolic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001940:Breast / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D004334:Drug Administration Schedule; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D011388:Prolactin / Q000096:biosynthesis* / Q000187:drug effects; D011897:Random Allocation; D012756:Sheep; D014204:Trenbolone Acetate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*
D045930:Anabolic Agents; D004958:Estradiol; D011388:Prolactin; D014204:Trenbolone Acetate