Sympathetic activity and the heterogenous blood pressure response to exercise training in hypertensives.
To test whether changes in sympathetic nervous system (SNS) activity or insulin sensitivity contribute to the heterogeneous blood pressure response to aerobic exercise training, we used compartmental analysis of [3H]norepinephrine kinetics to determine the extravascular norepinephrine release rate (NE2) as an index of systemic SNS activity and determined the insulin sensitivity index (S(I)) by an intravenous glucose tolerance test, before and after 6 mo of aerobic exercise training, in 30 (63 +/- 7 yr) hypertensive subjects. Maximal O2 consumption increased from 18.4 +/- 0.7 to 20.8 +/- 0.7 ml x kg(-1) x min(-1) (P = 0.02). The average mean arterial blood pressure (MABP) did not change (114 +/- 2 vs. 114 +/- 2 mmHg); however, there was a wide range of responses (-19 to +17 mmHg). The average NE2 did not change significantly (2.11 +/- 0.15 vs. 1.99 +/- 0.13 microg x min(-1) x m(-2)), but there was a significant positive linear relationship between the change in NE2 and the change in MABP (r = 0.38, P = 0.04). S(I) increased from 2.81 +/- 0.37 to 3.71 +/- 0.42 microU x 10(-4) x min(-1) x ml(-1) (P = 0.004). The relationship between the change in S(I) and the change in MABP was not statistically significant (r = -0.03, P = 0.89). When the changes in maximal O2 consumption, percent body fat, NE2, and S(I) were considered as predictors of the change in MABP, only NE2 was a significant independent predictor. Thus suppression of SNS activity may play a role in the reduction in MABP and account for a portion of the heterogeneity of the MABP response to aerobic exercise training in older hypertensive subjects.
Brown
Michael D
MD
Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan Health System and Geriatric Research, Education, and Clinical Center, Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan 48105, USA. mb166@umail.umd.edu
Dengel
Donald R
DR
Hogikyan
Robert V
RV
Supiano
Mark A
MA
D000368:Aged; D000375:Aging / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D001823:Body Composition; D015444:Exercise / Q000502:physiology*; D005260:Female; D005542:Forearm / Q000098:blood supply; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007004:Hypoglycemic Agents; D007328:Insulin; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood / Q000493:pharmacokinetics; D010101:Oxygen Consumption / Q000502:physiology; D010121:Oxytocin / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*; D014316:Tritium
D007004:Hypoglycemic Agents; D007328:Insulin; D014316:Tritium; D010121:Oxytocin; D009638:Norepinephrine