title: Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation.
abstract: Micro RNAs are a large family of noncoding RNAs of 21-22 nucleotides whose functions are generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly complementary to several classes of sequence motif previously demonstrated to mediate negative post-transcriptional regulation. These findings suggest a more general role for micro RNAs in gene regulation through the formation of RNA duplexes.
authors.affiliation: University of California at Berkeley, Department of Molecular and Cell Biology, 545 Life Sciences Addition #3200, Berkeley, California 94720-3200, USA. lai@fruitfly.bdgp.berkeley.edu
authors.forename: Eric C
authors.initials: EC
authors.lastname: Lai
mesh_terms: D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D020816:Amino Acid Motifs; D000818:Animals; D001483:Base Sequence; D017173:Caenorhabditis elegans / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D035683:MicroRNAs; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D016372:RNA, Antisense / Q000737:chemistry* / Q000235:genetics*; D022661:RNA, Untranslated / Q000737:chemistry* / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D035683:MicroRNAs; D016372:RNA, Antisense; D022661:RNA, Untranslated