title: [Expression of the protein marker p16INK4a in the cervix uteri cancer].
abstract: Immunohistochemical study was carried out of 18 cervical carcinomas (13 squamous and 5 adenomatous) and of 3 cases of cervical intraepithelial dysplasia. Formalin-fixed paraffin-embedded tissue samples from biopsies as well as from surgical material were used. Staining was performed with monoclonal antibodies to protein p16INK4a. Cytologic smears of epithelial cervical cells from 7 healthy women were taken as a negative control. The reference group consisted of 5 cancer patients with other tumors (breast cancer, B-cell lymphoma). Overexpression of p16INK4a was registered in cervical cancer.
authors.affiliation: N.N. Blokhin Cancer Research Center, 115478, Moscow.
authors.forename: G M
authors.initials: GM
authors.lastname: Volgareva
authors.forename: L E
authors.initials: LE
authors.lastname: Zavalishina
authors.forename: G A
authors.initials: GA
authors.lastname: Frank
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Andreeva
authors.forename: A N
authors.initials: AN
authors.lastname: Petrov
authors.forename: F L
authors.initials: FL
authors.lastname: Kiselev
authors.forename: D D
authors.initials: DD
authors.lastname: Spitkovskiĭ
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002578:Uterine Cervical Dysplasia / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16