Is magnetic resonance imaging texture analysis a useful tool for cell therapy in vivo monitoring?
Assessment of anti-tumor treatment efficiency is usually done by measuring tumor size. Treatment may however induce changes in the tumor other than tumor size. Magnetic Resonance Imaging Texture Analysis (MRI-TA) is presently used to follow activated lymphocyte cell therapy. We used a 7T microimager to acquire high-resolution MR images of an experimental liver metastasis from colon carcinoma in rats treated (n = 4) or not (n = 3) with a cell therapy product. MRI-TA was then performed with Linear Discriminant Analysis and showed: i) a significant variation of tumor texture with tumor growth and ii) a significant modification in the texture of tumors treated with activated lymphocytes compared with untreated tumors. T2-weighted images or volume calculation did not evidence any difference. MRI-TA appears as a promising method for early detection and follow-up of response to cell therapy.
Eliat
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PA
Laboratoire de Résonance Magnétique en Biologie et Médecine & IFR91 Imagerie Métabolique et Modélisation, Faculté de Médecine, Rennes, France. pierre-antoine.eliat@univ-rennes1.fr
Lechaux
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D
Gervais
A
A
Rioux-Leclerc
N
N
Franconi
F
F
Lemaire
L
L
Dazord
L
L
Catros-Quemener
V
V
de Certaines
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JD
D000230:Adenocarcinoma / Q000276:immunology / Q000556:secondary* / Q000628:therapy*; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D003110:Colonic Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D016219:Immunotherapy, Adoptive / Q000379:methods*; D008114:Liver Neoplasms, Experimental / Q000276:immunology / Q000556:secondary* / Q000628:therapy*; D008213:Lymphocyte Activation / Q000276:immunology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015166:Monitoring, Immunologic / Q000379:methods; D008991:Monitoring, Physiologic / Q000379:methods; D051381:Rats