Role of the Hha/YmoA family of proteins in the thermoregulation of the expression of virulence factors.
Virulent bacteria are able to sense temperature changes and respond by modifying the expression of--among others--genes that code for virulence factors. The chromatin-associated protein H-NS has been shown to play a role in the thermomodulation of virulence factor expression. In addition to H-NS, proteins of the Hha/YmoA family have also been identified in different enterobacteria as participating in the thermoregulation of some virulence factors. For one of these proteins, the Hha protein, it has been shown that it interacts with H-NS, and both proteins form a nucleoid-protein complex responsible for the thermoregulation of, at least, E. coli hemolysin. The presence of genes coding for homologues of both proteins on some conjugative plasmids and their relation to thermoregulation suggests that this complex could also play a role in the regulation of plasmid transfer.
Madrid
Cristina
C
Departament de Microbiologia, Universitat de Barcelona, Spain.
Nieto
José M
JM
Juárez
Antonio
A
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial; D006460:Hemolysin Proteins / Q000096:biosynthesis / Q000235:genetics; D008969:Molecular Sequence Data; D010957:Plasmids; D011485:Protein Binding; D016415:Sequence Alignment; D013696:Temperature; D014774:Virulence; D015007:Yersinia / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C031908:H-NS protein, bacteria; D006460:Hemolysin Proteins; C079210:YmoA protein, Yersinia enterocolitica; C079209:hha protein, E coli