Antiepiligrin (laminin 5) cicatricial pemphigoid complicated and exacerbated by herpes simplex virus type 2 infection.
A 50-year-old man with antiepiligrin (laminin 5) cicatricial pemphigoid (AeCP) involving the eyes, mouth and skin required a combination of systemic drug therapies to suppress the ocular disease. Herpes simplex virus type 2 infection of the mouth and pharynx precipitated an acute deterioration, with laryngeal involvement and an increase in oral ulceration. This is an unusual complication of long-term immunosuppression and illustrates some of the difficulties in the management of patients with AeCP. Clinical improvement was obtained with oral antiviral therapy and adjustment of his immunosuppressive regimen.
Gilmour
T K
TK
Department of Dermatology, Addenbrooke's Hospital, Cambridge, United Kingdom. tkgilmour@ozemail.com.au
Meyer
P A
PA
Rytina
E
E
Todd
P M
PM
D015075:2-Aminopurine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D015815:Cell Adhesion Molecules / Q000276:immunology*; D004359:Drug Therapy, Combination; D000077595:Famciclovir; D006566:Herpesviridae Infections / Q000150:complications* / Q000188:drug therapy; D018258:Herpesvirus 2, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D010390:Pemphigoid, Benign Mucous Membrane / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D011239:Prednisolone / Q000627:therapeutic use; D000097794:Kalinin
D015075:2-Aminopurine; D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D015815:Cell Adhesion Molecules; D000077595:Famciclovir; D011239:Prednisolone; D000097794:Kalinin