Sarcoidosis with prominent giant cells.
A 31-year-old man presented with a widespread papular eruption and systemic symptoms including renal colic and decreased exercise tolerance. The combination of clinical features and laboratory investigations that revealed an elevated angiotensin converting enzyme level and hypercalcaemia enabled a diagnosis of sarcoidosis to be made. Multiple skin biopsies showed prominent Touton-like giant cells which delayed the diagnosis. Giant cells are frequently seen in sarcoidal granulomas but in some cases their prominence and Touton-like appearance may suggest alternative diagnoses such as xanthogranulomas.
Drummond
C
C
Skin and Cancer Foundation Australia, Sydney, New South Wales, Australia. cjdrummond@bigpond.com
Savdie
E
E
Kossard
S
S
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D003937:Diagnosis, Differential; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D006934:Hypercalcemia / Q000097:blood; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D012507:Sarcoidosis / Q000097:blood / Q000473:pathology*; D012878:Skin Neoplasms / Q000097:blood / Q000473:pathology*
D015415:Biomarkers; D007703:Peptidyl-Dipeptidase A