Antiproliferative action of vitamin D.
During the past few years, it has become apparent that vitamin D may play an important role in malignant transformation. Epidemiological studies suggest that low vitamin D serum concentration increases especially the risk of hormone-related cancers. Experimentally, vitamin D suppresses the proliferation of normal and malignant cells and induces differentiation and apoptosis. In the present review we discuss the mechanisms whereby vitamin D regulates cell proliferation and whether it could be used in prevention and treatment of hyperproliferative disorders like cancers.
Ylikomi
Timo
T
Graduate School of Biomedicine, Department of Cell Biology, 33014 University of Tampere, Finland.
Laaksi
Ilkka
I
Lou
Yan-Ru
YR
Martikainen
Paula
P
Miettinen
Susanna
S
Pennanen
Pasi
P
Purmonen
Sami
S
Syvälä
Heimo
H
Vienonen
Annika
A
Tuohimaa
Pentti
P
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006131:Growth Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D014807:Vitamin D / Q000494:pharmacology* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D014807:Vitamin D