Red cell aplasia due to erythrovirus parvovirus B19 infection in a Jehovah's witness with post-transplant EBV-induced aggressive lymphoma: management considerations.
The refusal of Jehovah's Witnesses to accept blood and blood products often poses a clinical dilemma to present day medicine. We present a case of a Jehovah's Witness who had undergone renal transplantation, only to develop an Epstein-Barr virus associated aggressive lymphoma post-transplant. His condition was further complicated by erythrovirus (parvovirus) B 19 infection resulting in red cell aplasia and severe anemia. The management of this difficult clinical situation is discussed together with a review of recommendations for chemotherapy treatment in Jehovah's Witnesses.
Murdock
J
J
Department of Haematology, Belfast City Hospital, Northern Ireland, UK.
Morris
T C M
TC
Alexander
H D
HD
McNamee
P
P
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D019468:Disease Management; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000209:etiology; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D033221:Jehovah's Witnesses; D016030:Kidney Transplantation / Q000009:adverse effects*; D016393:Lymphoma, B-Cell / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000821:virology*; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications* / Q000209:etiology; D016732:Parvovirus B19, Human; D012010:Red-Cell Aplasia, Pure / Q000209:etiology / Q000821:virology*