New thiazane and thiazolidine PNA monomers: synthesis, incorporation into PNAs and hybridization studies.
New constrained PNA monomers containing a substituted thiazolidine or a thiazane ring were synthesized and incorporated in the center of a 9-mer homothymine PNA. The PNA/DNA hybrids stability was studied by UV-melting experiments which showed that the presence of the modified unit destabilizes the PNA/DNA triplexes.
Bregant
Sarah
S
Laboratoire de Chimie Organique Biologique, Université P. et M. Curie, CNRS-UMR 7613, 4 place Jussieu, 75252 Paris Cedex 05, France.
Burlina
Fabienne
F
Chassaing
Gérard
G
D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009696:Nucleic Acids / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D013053:Spectrophotometry; D013237:Stereoisomerism; D013696:Temperature; D013816:Thermodynamics; D013843:Thiazines / Q000737:chemistry* / Q000378:metabolism; D013844:Thiazoles / Q000737:chemistry* / Q000378:metabolism
D009696:Nucleic Acids; D020135:Peptide Nucleic Acids; D013843:Thiazines; D013844:Thiazoles; D012313:RNA; D004247:DNA