Long-term potentiation in rat prefrontal slices facilitated by phased application of dopamine.
We have previously shown that coupling bath application of dopamine with 50 Hz tetani induces long-term depression in rat prefrontal slices [Neuroscience 85 (1998) 669]. Here, we report a reliable protocol for inducing long-term potentiation in the same preparation. Long-term potentiation was induced by the same dopamine-tetani coupling protocol when the coupling was preceded (approximately 30 min) by a single bath application of dopamine. We suggest that metaplastic processes triggered by the first application of dopamine might underlie the LTP induction.
Blond
Olivier
O
FRE 2371 Neurobiologie des Processus Adaptatifs UMR 7102, Université de Paris VI, case 8, Building B, 6th floor, 7, quai Saint Bernard, 75005 Paris, France.
Crépel
Francis
F
Otani
Satoru
S
D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D004298:Dopamine