Axon guidance: the cytoplasmic tail.
Recent advances in the study of axon guidance have begun to clarify the intricate signalling mechanisms utilised by receptors that mediate path-finding. Many of these axon guidance receptors, including Plexin B, EphA, ephrin B and Robo, regulate the Rho family of GTPases, to effect changes in motility. Recent studies demonstrate a critical role for the cytoplasmic tails of guidance receptors in signalling and also reveal the potential for a great deal of crosstalk between the various receptor-signalling pathways.
Patel
Bharatkumar N
BN
Program in Neuroscience, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. bpatel@hms.harvard.edu
Van Vactor
David L
DL
D000818:Animals; D001369:Axons / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D006801:Humans; D020239:Receptor Cross-Talk / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D020558:GTP Phosphohydrolases