Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway.
When pre-mRNAs are spliced, a multi-component complex is deposited onto them, close to the sites of intron removal. New findings suggest that these exon-exon junction complexes and the complexes that bind mRNA caps are key effectors of the fate of spliced mRNAs and may regulate whether mRNAs containing premature stop codons are degraded.
Schell
Thomas
T
EMBL Heidelberg, Gene Expression Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany. hentze@embl-heidelberg.de
Kulozik
Andreas E
AE
Hentze
Matthias W
MW
D000818:Animals; D018389:Codon, Nonsense / Q000235:genetics*; D005091:Exons / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D014176:Protein Biosynthesis / Q000235:genetics*; D011786:Quality Control; D039381:RNA Cap-Binding Proteins; D012326:RNA Splicing / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000502:physiology
D018389:Codon, Nonsense; D039381:RNA Cap-Binding Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins