title: Cytotoxic constituents of the stem bark of Neolitsea acuminatissima.
abstract: Three new eudesmanolide sesquiterpenes, neolitacumone A-C (1-3), and one new benzylisoquinoline alkaloid, neolitacumonine (5), along with 27 known compounds were isolated from the stem bark of Neolitsea acuminatissima. The structures of compounds 1-3 and 5 were established on the basis of spectral and chemical evidence. Compounds 2, 3, and 20 were selectively inhibitory to Hep 2,2,15 cells with IC50 values in the range 0.24-0.04 microg/mL. Compound 20 was marginally cytotoxic to Hep G2 cells.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Tian-Jye
authors.initials: TJ
authors.lastname: Hsieh
authors.forename: Ti-Lung
authors.initials: TL
authors.lastname: Huang
authors.forename: Chung-Yi
authors.initials: CY
authors.lastname: Chen
authors.forename: Reen-Yen
authors.initials: RY
authors.lastname: Kuo
authors.forename: Yuh-Chwen
authors.initials: YC
authors.lastname: Chang
authors.forename: Hui-Fen
authors.initials: HF
authors.lastname: Chiu
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D004354:Drug Screening Assays, Antitumor; D006515:Hepatitis B virus; D006801:Humans; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification*; D019770:Lauraceae / Q000737:chemistry*; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013624:Taiwan; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D016227:Benzoquinones; D007546:Isoquinolines; D012717:Sesquiterpenes; C452828:neolitacumone A; C452829:neolitacumone B; C452830:neolitacumone C; C452831:neolitacumonine; C030511:2,6-dimethoxy-1,4-benzoquinone