Severe hypophosphatemia: a rare cause of intravascular hemolysis.
A 3-year-old child presented with severe hyperphosphatemia (phosphate 45 mg/dL) secondary to chronic enema use. Following aggressive correction of the hyperphosphatemia, hypophosphatemia ensued (phosphate 1.7 mg/dL). Concurrently, the patient developed severe intravascular hemolysis and RBC morphologic defects. The hemolysis and morphologic defects corrected with return to normal serum phosphate levels. Severe hypophosphatemia is a rare cause of intravascular hemolysis.
Melvin
Jennifer D
JD
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233. USA.
Watts
Raymond G
RG
D000743:Anemia, Hemolytic / Q000097:blood / Q000209:etiology; D002675:Child, Preschool; D004733:Enema / Q000009:adverse effects; D004912:Erythrocytes / Q000473:pathology; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D017674:Hypophosphatemia / Q000097:blood / Q000150:complications* / Q000209:etiology; D008297:Male; D010710:Phosphates / Q000097:blood
D010710:Phosphates