title: Extensive conservation of sequences and chromatin structures in the bxd polycomb response element among Drosophilid species.
abstract: The Polycomb Response Element (PRE) is the nucleation site for the Polycomb silencing complexes. The sequences responsible for the recruitment of the components of the Polycomb complex are not well understood. A comparison of the bxd PRE sequences from several different Drosophila species shows that some changes have occurred during phylogeny but large blocks of sequence are conserved after a divergence of some 60 million years. We compare the PRE sequences, the sites of some known PRE binding proteins, the conservation of DNasel hypersensitive sites and relate them to the sequence of the Ultrabithorax promoter which these PREs regulate.
authors.affiliation: Department of Zoology, University of Geneva, Switzerland.
authors.forename: Gaetano I
authors.initials: GI
authors.lastname: Dellino
authors.forename: Christophe
authors.initials: C
authors.lastname: Tatout
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Pirrotta
mesh_terms: D000818:Animals; D001483:Base Sequence; D002843:Chromatin / Q000737:chemistry* / Q000235:genetics*; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000235:genetics; D003850:Deoxyribonuclease I / Q000378:metabolism; D004330:Drosophila / Q000145:classification* / Q000235:genetics* / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics; D018398:Homeodomain Proteins; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010802:Phylogeny; D063150:Polycomb Repressive Complex 1; D011401:Promoter Regions, Genetic; D020218:Response Elements; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014157:Transcription Factors
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; C066770:Pc protein, Drosophila; D014157:Transcription Factors; C066177:Ubx protein, Drosophila; D063150:Polycomb Repressive Complex 1; D003850:Deoxyribonuclease I