Role of chemokines in the pathogenesis of asthma.
The prevalence of asthma has risen drastically in the last two decades, with a worldwide impact on health care systems. Although several factors contribute to the development of asthma, inflammation seems to be a common factor that leads to the most severe asthmatic responses. In the past decade, researchers have characterized a large group of chemotactic cytokines, also known as chemokines, which are implicated in asthmatic inflammation. These chemokines control and direct the migration and activation of various leukocyte populations. Targeting chemokines should lead to new ways of controlling the inflammatory asthmatic response.
Lukacs
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University of Michigan Medical School, Department of Pathology, Ann Arbor, Michigan 48109-0602, USA. nlukacs@umich.edu
D000818:Animals; D001249:Asthma / Q000209:etiology* / Q000276:immunology; D018925:Chemokines / Q000276:immunology*; D004804:Eosinophils / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology; D008168:Lung / Q000276:immunology; D018448:Models, Immunological; D019707:Receptors, Chemokine / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D018925:Chemokines; D018836:Inflammation Mediators; D019707:Receptors, Chemokine