title: Nature and extent of gastric lesions in symptomatic Chilean children with Helicobacter pylori-associated gastritis.
abstract: Chile has one of the highest rates of gastric cancer in the world and most children and adolescents in the country are colonized by Helicobacter pylori. This study assessed the nature and extent of the gastric lesions in 73 consecutive patients aged 5-17 y, referred for upper gastrointestinal endoscopy. Their H. pylori-associated gastric pathology was characterized and these data were compared with their sociodemographic status. Endoscopic assessment was normal in 43 patients while in 30 there was a variety of mucosal lesions. Sixty patients (83%) had histological chronic gastritis of the antrum and in 45 (63%) the lesions also involved the gastric corpus; 90% of patients with chronic gastritis were colonized by H. pylori. Although most of these patients had epithelial erosions and dedifferentiation of the pit epithelium, atrophy and metaplasia were not found. Patients' socioeconomic status was inversely correlated with their rate of colonization by H. pylori (p < 0.005), the frequency of gastric lesions on endoscopy (p < 0.01) and the frequency of involvement of antral and corpus mucosa by chronic gastritis (p < 0.002). This latter feature was positively correlated with age (p < 0.001).
  
  
  CONCLUSIONS
  This study shows a high frequency of extensive lesions of H. pylori-associated chronic gastritis in young Chilean patients. This histological picture is consistent with the hypothesis of a H. pylori-associated progressive gastric pathology which may represent a major factor in the high local rate of gastric cancer.
authors.affiliation: Departamento de Pediatría, Pontificia Universidad Católica de Chile, Santiago. eguirald@puc.cl
authors.forename: E
authors.initials: E
authors.lastname: Guiraldes
authors.forename: A
authors.initials: A
authors.lastname: Peña
authors.forename: I
authors.initials: I
authors.lastname: Duarte
authors.forename: X
authors.initials: X
authors.lastname: Triviño
authors.forename: M
authors.initials: M
authors.lastname: Schultz
authors.forename: F
authors.initials: F
authors.lastname: Larraín
authors.forename: M N
authors.initials: MN
authors.lastname: Espinosa
authors.forename: P
authors.initials: P
authors.lastname: Harris
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D002908:Chronic Disease; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology*; D005756:Gastritis / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology*; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D015995:Prevalence; D011336:Probability; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution