Transforming growth factor-beta in T-cell biology.
Strict control of T-cell homeostasis is required to permit normal immune responses and prevent undesirable self-targeted responses. Transforming growth factor-beta (TGF-beta) has been shown to have an essential role in that regulation. Owing to its broad expression, and inhibitory effects on multiple cell types of the immune system, TGF-beta regulation is complex. Through advances in cell-specific targeting of TGF-beta signalling in vivo, the role of TGF-beta in T-cell regulation has become clearer. Recent in vitro studies provide a better understanding of how TGF-beta regulates T-cell homeostasis, through multiple mechanisms involving numerous cell types.
Gorelik
Leonid
L
Biogen, Inc, Cambridge, Massachusetts 02139, USA.
Flavell
Richard A
RA
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D017209:Apoptosis; D001324:Autoantigens; D015551:Autoimmunity; D002454:Cell Differentiation; D006706:Homeostasis; D006801:Humans; D008213:Lymphocyte Activation; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000276:immunology*
D001324:Autoantigens; D016212:Transforming Growth Factor beta