title: [Primary cutaneous cryptococcosis in HIV-seronegative subjects].
abstract: BACKGROUND
  Primary cutaneous cryptococcosis is an uncommon clinical entity characterized by direct skin inoculation without systemic involvement. We report four cases of this affection in HIV-negative patients seen between 1990 and 1999 in Nantes Dermatological Clinic.
  
  
  METHODS
  Patients mean age was seventy. Three patients had recent exposure to soil or birds, and two remembered a trauma before the lesion appeared. In three cases the lesion was on the hand. In two cases the lesion was an ulcerated nodule, in another an abscess and in the last a cellulitis. Two subjects were treated by fludarabin and systemic corticosteroids for respectively chronic lymphocytic leukemia and Waldenstrom's macroglobulinemia. The third had a CD4 lymphopenia. Cultural examination confirmed the diagnosis. Treatment, with fluconazole in 3 cases and ketoconazole and itraconazole in 1 case, resulted in healing of the skin lesion in a few months.
  
  
  CONCLUSIONS
  Recognition of primary cutaneous cryptococcosis as a clinical entity has long been debated. An altered immunological status is an important factor for developing this disease. There is often a clear history of trauma or exposure to soil or birds preceding the development of the lesion. Clinically it often looks like a papule or an ulcerated nodule. The lesion is confined to the skin without systemic involvement. The prognosis is excellent thanks to the use of oral antifungal imidazoles.
authors.affiliation: Clinique Dermatologique, Hôtel-Dieu, Nantes.
authors.forename: G
authors.initials: G
authors.lastname: Quéreux
authors.forename: B
authors.initials: B
authors.lastname: Milpied
authors.forename: O
authors.initials: O
authors.lastname: Morin
authors.forename: P
authors.initials: P
authors.lastname: Andrès
authors.forename: E
authors.initials: E
authors.lastname: Parant
authors.forename: P
authors.initials: P
authors.lastname: Poirier
authors.forename: M J
authors.initials: MJ
authors.lastname: Rapp
authors.forename: J F
authors.initials: JF
authors.lastname: Stalder
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003453:Cryptococcosis / Q000473:pathology*; D003881:Dermatomycoses / Q000473:pathology*; D005260:Female; D018023:HIV Seronegativity; D006801:Humans; D008297:Male; D008875:Middle Aged