Quinoxaline chemistry. Part 14. 4-(2-Quinoxalylamino)-phenylacetates and 4-(2-quinoxalylamino)-phenylacetyl-L-glutamates as analogues--homologues of classical antifolate agents. Synthesis and evaluation of in vitro anticancer activity.
Among a new series of 26 4-(3-substituted-2-quinoxalylamino)phenylacetates and 4-(3-substituted-2-quinoxalylamino)-phenylacetyl-L-glutamates, eight were selected at NCI for evaluation of their in vitro anticancer activity. The results obtained in comparison with the corresponding nor-compounds series seem to indicate that this type of homologation is not helpful.
Piras
Sandra
S
Dipartimento Chimico Tossicologico, Università di Sassari, Italy.
Loriga
Mario
M
Paglietti
Giuseppe
G
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D010648:Phenylacetates / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D010648:Phenylacetates; D011810:Quinoxalines