A 3,4-epoxypiperidine structure as a novel and simple DNA-cleavage unit.
Based on the 4-hydroxy-1-azabicyclo[3.1.0]hexane structure of azinomycin, a 3,4-epoxypiperidine structure was designed as a novel and simple alkylating molecular unit, and some 3,4-epoxypiperidine derivatives were found to show DNA-cleavage activity, the structural requirements for which were revealed.
Miyashita
Kazuyuki
K
Graduate School of Pharmaceutical Sciences Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Park
Myunji
M
Adachi
Sayako
S
Seki
Sayori
S
Obika
Satoshi
S
Imanishi
Takeshi
T
D000477:Alkylating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D004249:DNA Damage; D015195:Drug Design; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
C465229:3,4-epoxypiperidine; D000477:Alkylating Agents; D004852:Epoxy Compounds; D010880:Piperidines; D004247:DNA