Design of Peumus boldus tablets by direct compression using a novel dry plant extract.
A solid pharmaceutical dosage formulation using a novel dry plant extract of Peumus boldus MOL. (Monimiaceae) (Pb) is proposed. The botanical evaluation of plant material, through morphological and anatomical diagnosis, is presented. This evaluation permits to identify the herb to be used correctly. The analysis of the most extractive solvent mixture and the attainment of plant extract (fluid and dry) are reported. Several formulations (tablets) containing a novel dry plant extract of Pb and common excipients for direct compression are evaluated. The following formulation: dry plant extract of Pb (170 mg), Avicel PH101 (112 mg), Lactose CD (112) and magnesium stearate (6 mg), compressed at 1000 mPa, showed the best pharmaceutical performance.
Palma
Santiago
S
Departamento de Farmacia, Faculdad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria-5000, Córdoba, Argentina.
Luján
Claudia
C
Llabot
Juan Manuel
JM
Barboza
Gloria
G
Manzo
Ruben Hilario
RH
Allemandi
Daniel Alberto
DA
D002626:Chemistry, Pharmaceutical; D019245:Compressive Strength; D006244:Hardness; D029585:Monimiaceae / Q000033:anatomy & histology* / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000033:anatomy & histology* / Q000737:chemistry*; D010946:Plants, Medicinal / Q000033:anatomy & histology / Q000737:chemistry; D011208:Powders; D012212:Rheology; D013607:Tablets
D010936:Plant Extracts; D011208:Powders; D013607:Tablets