title: Genetics of programmed cell death and proliferation.
abstract: Vascular remodeling and hypertrophy-hyperplasia of the heart and kidney are the hallmarks of hypertensions, being involved in the long-term maintenance of elevated blood pressure and the development of cardiovascular and renal hypertension. Both augmented proliferation and unscheduled programmed cell death (apoptosis) contribute to this phenomenon. In the present article, we summarize the results of these studies with an emphasis on the relative impact of genetic determinants and the environment.
authors.affiliation: Centre de recherche, Centre hospitalier de l'Université de Montréal Hôtel-Dieu, Université de Montréal, Montreal, Québec, Canada.
authors.forename: Sergei N
authors.initials: SN
authors.lastname: Orlov
authors.forename: Johanne
authors.initials: J
authors.lastname: Tremblay
authors.forename: Denis
authors.initials: D
authors.lastname: Deblois
authors.forename: Pavel
authors.initials: P
authors.lastname: Hamet
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics* / Q000502:physiology; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D002455:Cell Division / Q000235:genetics; D016922:Cellular Senescence; D006965:Hyperplasia / Q000503:physiopathology; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D006984:Hypertrophy / Q000503:physiopathology; D007668:Kidney / Q000166:cytology; D023421:Models, Animal; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D010641:Phenotype