Mitotic exit: delaying the end without FEAR.
Activation of Cdc14 phosphatase, controlled by a signalling cascade known as the mitotic exit network, is the final switch that drives cells from mitosis into the next cell cycle. The recent discovery of a novel network that regulates early Cdc14 activation has revealed the unexpected existence of a two-step control of mitotic exit.
Jensen
Sanne
S
Division of Yeast Genetics, National Institute for Medical Research, London, UK.
Geymonat
Marco
M
Johnston
Leland H
LH
D000705:Anaphase / Q000502:physiology; D018797:Cell Cycle Proteins / Q000378:metabolism*; D005656:Fungal Proteins; D019204:GTP-Binding Proteins / Q000378:metabolism; D008938:Mitosis; D009687:Nuclear Proteins; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases; D017027:Protein Tyrosine Phosphatases; D029701:Saccharomyces cerevisiae Proteins; D015398:Signal Transduction
C074860:CDC14 protein, S cerevisiae; C082279:CDC15 protein; D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D009687:Nuclear Proteins; C416648:SPO12 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; C081927:CDC5 protein, S cerevisiae; D017027:Protein Tyrosine Phosphatases; D019204:GTP-Binding Proteins