title: AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis.
abstract: In contrast to animals, little is known about pattern formation in plants. Physiological and genetic data suggest the involvement of the phytohormone auxin in this process. Here, we characterize a novel member of the PIN family of putative auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature root meristems. Atpin4 mutants are defective in establishment and maintenance of endogenous auxin gradients, fail to canalize externally applied auxin, and display various patterning defects in both embryonic and seedling roots. We propose a role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning.
authors.affiliation: Max-Delbrück-Laboratorium in der Max-Planck-Gesellschaft, Köln, Germany.
authors.forename: Jirí
authors.initials: J
authors.lastname: Friml
authors.forename: Eva
authors.initials: E
authors.lastname: Benková
authors.forename: Ikram
authors.initials: I
authors.lastname: Blilou
authors.forename: Justyna
authors.initials: J
authors.lastname: Wisniewska
authors.forename: Thorsten
authors.initials: T
authors.lastname: Hamann
authors.forename: Karin
authors.initials: K
authors.lastname: Ljung
authors.forename: Scott
authors.initials: S
authors.lastname: Woody
authors.forename: Goran
authors.initials: G
authors.lastname: Sandberg
authors.forename: Ben
authors.initials: B
authors.lastname: Scheres
authors.forename: Gerd
authors.initials: G
authors.lastname: Jürgens
authors.forename: Klaus
authors.initials: K
authors.lastname: Palme
mesh_terms: D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000166:cytology / Q000502:physiology*; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017930:Genes, Reporter; D017403:In Situ Hybridization; D007210:Indoleacetic Acids / Q000378:metabolism*; D026901:Membrane Transport Proteins; D018519:Meristem / Q000166:cytology / Q000378:metabolism; D008856:Microscopy, Fluorescence; D008969:Molecular Sequence Data; D018517:Plant Roots / Q000378:metabolism*; D012639:Seeds / Q000033:anatomy & histology / Q000502:physiology; D016415:Sequence Alignment
chemical_list: D029681:Arabidopsis Proteins; D002352:Carrier Proteins; D007210:Indoleacetic Acids; D026901:Membrane Transport Proteins; C451260:PIN4 protein, Arabidopsis