title: Henoch-Schönlein purpura with intracerebral hemorrhage.
abstract: We describe a case of Henoch-Schönlein purpura (HSP) with massive intracerebral hemorrhage (ICH) in a 7-year-old-girl. A cranial CT scan revealed extensive ICH in the left parietal region and right parieto-temporal through occipital regions. At the time of ICH onset, hypertension and coagulation abnormality were not observed, but factor XIII activity was markedly reduced 9%. ICH was thought to have resulted from a marked decrease in factor XIII. Factor XIII preparation was administered immediately after the onset of ICH, and enlargement of the hemorrhagic region was not seen. The present case is the only reported case of HSP complicated by ICH in which factor XIII level was measured.
authors.affiliation: Department of Pediatrics, Kagawa Medical University, Ikenobe 1750-1, Miki, Kitagun 761-0793, Japan. taboimai@kms.ac.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Imai
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Okada
authors.forename: Masanori
authors.initials: M
authors.lastname: Nanba
authors.forename: Kou
authors.initials: K
authors.lastname: Kawada
authors.forename: Takashi
authors.initials: T
authors.lastname: Kusaka
authors.forename: Susumu
authors.initials: S
authors.lastname: Itoh
mesh_terms: D002543:Cerebral Hemorrhage / Q000209:etiology*; D002648:Child; D005176:Factor XIII / Q000008:administration & dosage / Q000032:analysis*; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications*; D014057:Tomography, X-Ray Computed
chemical_list: D005176:Factor XIII