The relationship among serum insulin-like growth factor-I, insulin-like growth factor-I gene polymorphism, and bone mineral density in postmenopausal women in Korea.
OBJECTIVE
The objective of this study was to test the hypothesis that the cytosine-adenine polymorphism in the insulin-like growth factor-I gene is associated with serum insulin-like growth factor-I levels and bone mineral density.


METHODS
The insulin-like growth factor-I cytosine-adenine polymorphism was analyzed in 300 postmenopausal Korean women. Serum insulin-like growth factor-I, bone alkaline phosphatase, and carboxy-terminal cross-linking telopeptide of type I collagen were measured by immunoradiometric assay and enzyme-linked immunosorbent assay. Bone mineral density at the lumbar spine and proximal femur was determined by dual energy radiograph absorptiometry.


RESULTS
Serum insulin-like growth factor-I and bone mineral density levels in women who were homozygous for a 194-base pair allele were significantly higher than those levels in the 194-base pair heterozygotes or women who did not possess the 194-base pair allele. A significantly decreased prevalence of the 194/194 genotype was observed in the combined group of women with osteopenia and osteoporosis, compared with normal women. No correlation between insulin-like growth factor-I genotypes and bone turnover markers was found.


CONCLUSIONS
The insulin-like growth factor-I gene cytosine-adenine polymorphism relates with circulating insulin-like growth factor-I levels and bone mineral density at the lumbar spine and proximal femur.
Kim
Jung Gu
JG
Department of Obstetrics & Gynecology, Clinical Research Institute, College of Medicine, Seoul National University, Korea. kimjg@plaza.snu.ac.kr
Roh
Kyong Rock
KR
Lee
Jin Yong
JY
D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D015415:Biomarkers; D015519:Bone Density / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology; D018900:Dinucleotide Repeats; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000235:genetics*; D007723:Korea; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000502:physiology*; D017698:Postmenopause / Q000502:physiology*
D015415:Biomarkers; D007334:Insulin-Like Growth Factor I