Nuclear phosphoinositides could bring FYVE alive.
Phosphoinositide signalling systems exist in all eukaryotes. A high degree of evolutionary conservation is found at the functional level, but distinct phylogenetic differences are also becoming evident. Although the nuclear phosphoinositide system is likely to be a primordial forerunner of the plasma membrane system, relatively little is known about it. However, nuclear phosphoinositides might have far more diverse roles than hitherto envisaged and interact specifically with regulatory proteins containing phosphoinositide-binding domains. A novel family of proteins, so far only identified in plants, display domain structures that might link phosphoinositide metabolism to nuclear function in an unexpected way.
Drøbak
Bjørn K
BK
Cell Signalling Group, Dept of Disease and Stress Biology, John Innes Centre, Colney Lane, NR4 7UH, Norwich, UK. bjorn.drobak@bbsrc.ac.uk
Heras
Begoña
B
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites / Q000235:genetics; D002467:Cell Nucleus / Q000378:metabolism*; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D059828:Plant Cells; D011485:Protein Binding; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D009687:Nuclear Proteins; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; C060980:phosphatidylinositol 3,4-diphosphate; C106336:phosphatidylinositol 3,5-diphosphate; C113567:phosphatidylinositol 5-phosphate