[Papular acantholytic dyskeratosis].
Papular acantholytic dyskeratosis is a very rare skin disease, which shows a suprabasilar cleft with acantholytic and dyskeratotic cells, simulating the light microscopic picture of Darier disease. In this condition, the lesions are acquired without a genetic basis. We observed a 40-year-old woman with about 200 papules on the lower aspects of her legs; histological examination showed changes similar to Darier disease. Transmission electron microscopy showed a reduced number of desmosomes and perinuclear distribution of tonofilaments. The lesions were successfully treated with cryotherapy with spray technique.
de Almeida Júnior
H L
HL
Medizinische Fakultät der Bundesuniversität Pelotas, Av. Duque de Caxias 250, 96.030-002 Pelotas RS Brasilien. hiramalmeidajr@hotmail.com
Wolter
M
M
Castro
L A
LA
Rocha
N E
NE
D000051:Acantholysis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D000328:Adult; D017679:Cryotherapy; D007644:Darier Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008854:Microscopy, Electron; D012867:Skin / Q000473:pathology