title: Syntheses of 1beta-methylcarbapenems bearing 5-methyl-4-hydroxypyrrolidinone.
abstract: A new series of 1beta-methylcarbapenems 1a-d bearing 5-methyl-4-mercaptopyrrolidinone rings has been prepared and evaluated for in vitro antibacterial activity and pharmacokinetic parameters. Most compounds showed excellent antibacterial activity and high stability to dehydropeptidase-1. We have synthesized optically active 5-methyl-4-hydroxypyrrolidinones from enantiomerically pure aziridine esters.
authors.affiliation: Korea Research Institute of Chemical Technology, Yusung, Taejon.
authors.forename: Do Kyu
authors.initials: DK
authors.lastname: Pyun
authors.forename: Bong Jin
authors.initials: BJ
authors.lastname: Kim
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Jung
authors.forename: Jae Hak
authors.initials: JH
authors.lastname: Kim
authors.forename: Jin Soo
authors.initials: JS
authors.lastname: Lee
authors.forename: Won Koo
authors.initials: WK
authors.lastname: Lee
authors.forename: Cheol Hae
authors.initials: CH
authors.lastname: Lee
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D015780:Carbapenems / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011760:Pyrrolidinones / Q000737:chemistry*
chemical_list: C465554:5-methyl-4-hydroxypyrrolidinone; D000890:Anti-Infective Agents; D015780:Carbapenems; D011760:Pyrrolidinones