title: Epidermolysis bullosa acquisita responsive to dapsone therapy.
abstract: BACKGROUND
  Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal blistering disease that is frequently resistant to therapy.
  
  
  OBJECTIVE
  A 58-year-old man who had a one-year history of a bullous eruption involving the hands, forearms, trunk, scalp, and oral mucosa. Histopathology revealed a subepidermal bulla, and direct and indirect immunofluorescence studies were consistent with EBA. The patient failed respond to niacinamide and tetracycline and oral prednisone 40 mg per day.
  
  
  METHODS
  Complete control of his blistering was achieved within two months of initiating oral dapsone, 150 mg per day.
  
  
  CONCLUSIONS
  Dapsone may be an effective agent for some patients with EBA.
authors.affiliation: Division of Dermatology, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
authors.forename: A P
authors.initials: AP
authors.lastname: Hughes
authors.forename: J P
authors.initials: JP
authors.lastname: Callen
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D003622:Dapsone / Q000008:administration & dosage / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D016107:Epidermolysis Bullosa Acquisita / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003622:Dapsone