title: Cervical esophageal webs: association with gastroesophageal reflux.
abstract: BACKGROUND
  We investigated whether there is a significant association between cervical esophageal webs and gastroesophageal reflux on pharyngoesophagography.
  
  
  METHODS
  We studied 50 patients with cervical esophageal webs on pharyngoesophagrams and 50 control subjects. The control group was matched to the webs group for age, sex, and symptomatology. Patients with cervical esophageal webs and controls were compared to determine the prevalence of gastroesophageal reflux, hiatal hernias, reflux esophagitis, and abnormal esophageal motility. Pearson's chi-square test was used to determine any statistically significant differences in the frequencies of these findings between groups.
  
  
  RESULTS
  Thirty-nine (78%) of 50 patients with cervical esophageal webs versus 27 (54%) of 50 patients in the control group had gastroesophageal reflux (p = 0.01). When patients were classified based on degree of gastroesophageal reflux, 22 (44%) of 50 patients with cervical esophageal webs versus 21 (42%) of 50 controls had mild reflux (p = 0.84), whereas 17 (34%) of 50 patients with webs versus six (12%) of 50 controls (p < 0.009) had moderate/marked reflux. Thus, the prevalence of moderate/marked gastroesophageal reflux was significantly greater in patients with webs than in the controls. However, no significant differences were found in the prevalence of mild gastroesophageal reflux, hiatal hernias, reflux esophagitis, or abnormal esophageal motility.
  
  
  CONCLUSIONS
  We found a significant association between cervical esophageal webs and gastroesophageal reflux independent of age, sex, or symptomatology. Radiologists should be aware of this association, so that patients with cervical esophageal webs on pharyngoesophagography are evaluated for gastroesophageal reflux at the time of the barium study or advised to undergo further testing for gastroesophageal reflux disease.
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, 19104, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Gordon
authors.forename: M S
authors.initials: MS
authors.lastname: Levine
authors.forename: R O
authors.initials: RO
authors.lastname: Redfern
authors.forename: S E
authors.initials: SE
authors.lastname: Rubesin
authors.forename: I
authors.initials: I
authors.lastname: Laufer
mesh_terms: D016022:Case-Control Studies; D004935:Esophageal Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D015154:Esophageal Motility Disorders / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011859:Radiography