title: [Evaluation of likely antibiotherapy in bacterial-like acute pneumopathies in patients hospitalized in Africa].
abstract: We conducted a retrospective analysis of 100 records of adult African patients hospitalised for bacterial-like acute pneumonia. The objective of the study was to evaluate the use and efficacy of probabilist antibiotherapy. The study population was made up of 57% men and 43% women. Serious clinical symptoms were found in 31% of the patients, with serious x-ray and biological anomalies for respectively 67% and 51% cases. Secondary morbidity was associated with pneumonia in 30% cases. In the first intention, the three (3) most prescribed antibiotics are beta-lactamins (84%), fluoroquinolons (25%), and aminosids (25%). Sulfamids, macrolids and imidazols were prescribed together in 18% cases. Monotherapy was prescribed in 53% cases and concerned especially amoxicillin (39/53) and fluoroquinolons (5/53). Double therapy was used in 42% of cases and consisted of amoxicillin + aminosid (21/42) and amoxicillin + fluoroquinolon (17/42). Three antibiotics were noted for 5 cases. The intravenous administration was frequently used (68%), either alone (27%), either associated with other modes of drug administration (41%). Mean duration of antibiotherapy was 12.71 days. 73% of patients improved, 22% failed to improve and 5% died. Antibiotherapy was influenced by the seriousness biological signs and by the mode of administration of antibiotherapy in monotherapy. Deaths occurred precociously and concerned HIV positive (4/5) patients presenting at least 2 factors of co-morbidity and having received beta-lactamin in monotherapy.
authors.affiliation: Service de pneumologie, CHU de Cocody, BP 96 Abidjan 22, Côte d'Ivoire. koffinb@ci.refer.org
authors.forename: N
authors.initials: N
authors.lastname: Koffi
authors.forename: A
authors.initials: A
authors.lastname: Ngom
authors.forename: B
authors.initials: B
authors.lastname: Kouassi
authors.forename: K
authors.initials: K
authors.lastname: Horo
authors.forename: L
authors.initials: L
authors.lastname: Mansaré
authors.forename: E
authors.initials: E
authors.lastname: Aka-Danguy
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007560:Cote d'Ivoire / Q000453:epidemiology; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000627:therapeutic use; D006760:Hospitalization; D006801:Humans; D007769:Lactams; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy* / Q000453:epidemiology; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D007769:Lactams