Pharmacodynamics in the evaluation of drug regimens.
We believe, especially in an era of increasing antimicrobial resistance, that the integration of PK/PD models and stochastic techniques provides a powerful new tool to clinicians, researchers, and regulatory agencies alike. By using techniques such as these, we can begin to level the playing field so that PK/PD measures for therapeutic agents can be more accurately compared with greater certainty, and not be limited to discussions of susceptibility method variation or comparisons of MIC results.
Bhavnani
Sujata M
SM
Cognigen Corp., Buffalo, NY 14221-5831, USA.
Ambrose
Paul G
PG
Jones
Ronald N
RN
D019540:Area Under Curve; D004358:Drug Therapy; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods*; D010599:Pharmacokinetics; D010600:Pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects*