title: Developmental biology: vasculogenesis is a wreck without RECK.
abstract: The unique membrane-associated inhibitor of matrix metalloproteinases, RECK, is required for vascular maturation during embryogenesis. The phenotype of a loss of function mutation of RECK shows the importance of pericellular proteolysis in development.
authors.affiliation: Department of Anatomy, University of California, San Francisco, CA 94143-0452, USA. bwelm@itsa.ucsf.edu
authors.forename: Bryan
authors.initials: B
authors.lastname: Welm
authors.forename: Joni
authors.initials: J
authors.lastname: Mott
authors.forename: Zena
authors.initials: Z
authors.lastname: Werb
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001808:Blood Vessels / Q000196:embryology / Q000378:metabolism; D004730:Endothelium, Vascular / Q000254:growth & development*; D058851:GPI-Linked Proteins; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000378:metabolism*; D008969:Molecular Sequence Data; D009154:Mutation; D017386:Sequence Homology, Amino Acid; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000378:metabolism
chemical_list: D058851:GPI-Linked Proteins; D006023:Glycoproteins; D008562:Membrane Glycoproteins; C115460:RECK protein, human; C021240:tissue-factor-pathway inhibitor 2; D019716:Tissue Inhibitor of Metalloproteinase-2; D020782:Matrix Metalloproteinases