title: Butyltin compounds in human liver.
abstract: Intake of marine food is the main source of butyltin exposure in humans. Health effects following exposure to butyltin compounds are usually in the immune system, but endocrine effects of butyltin from a variety of marine species have been documented. The information on human exposure to butyltin compounds and hepatic deposition is limited. The present study include 18 consecutively sampled human livers analyzed for butyltin compounds. Dibutyltin (DBT) concentrations varied between 0.8 and 28.3 ng/g with a mean concentration of 9.0 ng/g. Significantly lower concentrations of monobutyltin (MBT) were observed, ranging from 0.3 to 4.7 ng/g with a mean value of 1.6 ng/g. Age and DBT/MBT ratio were significantly associated. We suggest that younger men have more recent exposures or have a lower capacity to debutylate DBT than older men and would therefore potentially be more susceptible to butyltin toxicity. Given the interperson variability observed in our limited group of men, we cannot exclude that thresholds for either immunotoxicity or effects on the endocrine system may occur due to exposure to butyltin compounds alone or in combination with other environmental toxicants with similar target organs.
authors.affiliation: Institute of Public Health, University of Southern Denmark, Odense C, DK-5000, Denmark.
authors.forename: Jesper B
authors.initials: JB
authors.lastname: Nielsen
authors.forename: Jakob
authors.initials: J
authors.lastname: Strand
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D004703:Endocrine System / Q000187:drug effects; D004781:Environmental Exposure; D006801:Humans; D007107:Immune System / Q000187:drug effects; D008099:Liver / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D014018:Tissue Distribution; D014220:Trialkyltin Compounds / Q000009:adverse effects / Q000493:pharmacokinetics*
chemical_list: D014220:Trialkyltin Compounds; C011559:tributyltin