title: Rheumatic manifestations of primary hyperparathyroidism and parathyroid hormone therapy.
abstract: A frequent manifestation of severe primary hyperparathyroidism was the bone disease osteitis fibrosa cystica. Rarely, excess parathyroid hormone (PTH) was associated with gout and calcium pyrophosphate crystal deposition disease. Surgical cure of primary hyperparathyroidism was occasionally associated with pseudogout. Today, primary hyperparathyroidism is generally asymptomatic. Clinically overt rheumatologic and skeletal effects are mainly of historical interest. Skeletal disease is still detectable by more sensitive techniques. In certain circumstances, PTH may be protective and anabolic for the skeleton.
authors.affiliation: Department of Medicine, College of Physicians & Surgeons, Columbia University, 630 W. 168th Street, New York, NY 10032, USA. sjs5@columbia.edu
authors.forename: Mishaela R
authors.initials: MR
authors.lastname: Rubin
authors.forename: Shonni J
authors.initials: SJ
authors.lastname: Silverberg
mesh_terms: D001847:Bone Diseases; D002805:Chondrocalcinosis; D006073:Gout; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000188:drug therapy*; D010281:Parathyroid Hormone / Q000627:therapeutic use*
chemical_list: D010281:Parathyroid Hormone