Cytokines and autoimmunity.
Cytokines have crucial functions in the development, differentiation and regulation of immune cells. As a result, dysregulation of cytokine production or action is thought to have a central role in the development of autoimmunity and autoimmune disease. Some cytokines, such as interleukin-2, tumour-necrosis factor and interferons--ostensibly, the 'bad guys' in terms of disease pathogenesis--are well known for the promotion of immune and inflammatory responses. However, these cytokines also have crucial immunosuppressive functions and so, paradoxically, can also be 'good guys'. The balance between the pro-inflammatory and immunosuppressive functions of these well-known cytokines and the implications for the pathogenesis of autoimmune disease is the focus of this review.
O'Shea
John J
JJ
Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch and Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. osheaj@arb.niams.nih.gov
Ma
Averil
A
Lipsky
Peter
P
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology; D015551:Autoimmunity; D016207:Cytokines / Q000276:immunology* / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology; D007372:Interferons / Q000276:immunology / Q000494:pharmacology; D007376:Interleukin-2 / Q000172:deficiency / Q000276:immunology / Q000494:pharmacology; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000494:pharmacology
D016207:Cytokines; D007166:Immunosuppressive Agents; D018836:Inflammation Mediators; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D007372:Interferons