title: Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus.
abstract: Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by gamma-aminobutyric acid type A (GABA(A)) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABA(A) receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.
authors.affiliation: Department of Psychiatry, State University of New York, Health Science Center, Brooklyn, NY 11203, USA.
authors.forename: Bernice
authors.initials: B
authors.lastname: Porjesz
authors.forename: Laura
authors.initials: L
authors.lastname: Almasy
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: Kongming
authors.initials: K
authors.lastname: Wang
authors.forename: David B
authors.initials: DB
authors.lastname: Chorlian
authors.forename: Tatiana
authors.initials: T
authors.lastname: Foroud
authors.forename: Alison
authors.initials: A
authors.lastname: Goate
authors.forename: John P
authors.initials: JP
authors.lastname: Rice
authors.forename: Sean J
authors.initials: SJ
authors.lastname: O'Connor
authors.forename: John
authors.initials: J
authors.lastname: Rohrbaugh
authors.forename: Samuel
authors.initials: S
authors.lastname: Kuperman
authors.forename: Lance O
authors.initials: LO
authors.lastname: Bauer
authors.forename: Raymond R
authors.initials: RR
authors.lastname: Crowe
authors.forename: Marc A
authors.initials: MA
authors.lastname: Schuckit
authors.forename: Victor
authors.initials: V
authors.lastname: Hesselbrock
authors.forename: P Michael
authors.initials: PM
authors.lastname: Conneally
authors.forename: Jay A
authors.initials: JA
authors.lastname: Tischfield
authors.forename: Ting-Kai
authors.initials: TK
authors.lastname: Li
authors.forename: Theodore
authors.initials: T
authors.lastname: Reich
authors.forename: Henri
authors.initials: H
authors.lastname: Begleiter
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D004569:Electroencephalography; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008126:Lod Score; D008875:Middle Aged; D005810:Multigene Family / Q000235:genetics; D019655:Quantitative Trait, Heritable; D011963:Receptors, GABA-A / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D011963:Receptors, GABA-A