2,3,7,8-Tetrachlorodibenzo-p-dioxin treatment induces c-Fos expression in the forebrain of the Long-Evans rat.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is one of the most toxic environmental pollutants. In the present study, we examined c-Fos expression in the central nervous system (CNS) after administration of a lethal dose of TCDD to the adult Long-Evans rat to clarify if the CNS participates in TCDD-induced intoxication. A single dose of TCDD (dissolved in olive oil, 50 microg/kg) or olive oil alone was administered to the rats by gavage. Animals were allowed to survive for 1 day to 5 weeks. Three days after the administration, a significantly large number of Fos-immunopositive cells were found in the hypothalamus (i.e. dorsomedial hypothalamic nucleus, paraventricular hypothalamic nucleus, medial preoptic nucleus), central amygdaloid nucleus and bed nucleus of the stria terminalis. These results suggest that some TCDD toxicity may be induced by its direct action on the CNS.
Cheng
Shi-Bin
SB
Department of Anatomy, Faculty of Medicine, Kagoshima University, Sakuragaoka 8-35-1, 890-8520, Japan.
Kuchiiwa
Satoshi
S
Nagatomo
Itsugi
I
Akasaki
Yasuaki
Y
Uchida
Masahiro
M
Tominaga
Masataka
M
Hashiguchi
Wataru
W
Kuchiiwa
Toshiko
T
Nakagawa
Shiro
S
D000284:Administration, Oral; D000679:Amygdala / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002452:Cell Count; D004435:Eating / Q000187:drug effects; D005260:Female; D007031:Hypothalamus / Q000378:metabolism / Q000473:pathology; D008297:Male; D000072317:Polychlorinated Dibenzodioxins / Q000008:administration & dosage / Q000633:toxicity*; D016548:Prosencephalon / Q000378:metabolism* / Q000473:pathology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D020318:Rats, Long-Evans; D012686:Septal Nuclei / Q000378:metabolism / Q000473:pathology; D012737:Sex Factors; D015996:Survival Rate; D013997:Time Factors
D000072317:Polychlorinated Dibenzodioxins; D016760:Proto-Oncogene Proteins c-fos