The linkage information content value of polymorphism genetic markers in model-free linkage analysis.
Guo and Elston [Hum Hered 1999;49:112-118] developed a linkage information content (LIC) value to measure the informativeness of a marker for identity-by-descent (IBD) sharing status of relative pairs. LIC values were derived for five types of relative pairs: full sib, half sib, grandparent-grandchild, first cousin and avuncular. In this paper, we give corrected LIC values for full sib, grandparent-grandchild, first cousin and avuncular pairs, and indicate the availability of a computer program to calculate them.
Guo
Xiuqing
X
Division of Medical Genetics, Department of Medicine and Pediatrics, Spielberg Pediatrics Research Center, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif. 90048, USA. Xiuqing.Guo@cshs.org
Olson
Jane M
JM
Elston
Robert C
RC
Niu
Tianhua
T
D002874:Chromosome Mapping / Q000379:methods*; D003627:Data Interpretation, Statistical; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D011110:Polymorphism, Genetic
D005819:Genetic Markers