The phosphatidylinositol 3-phosphate-binding FYVE finger.
The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions.
Stenmark
Harald
H
Department of Biochemistry, The Norwegian Radium Hospital, Oslo, Norway. h.a.stenmark@farmasi.uio.no
Aasland
Rein
R
Driscoll
Paul C
PC
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009348:Nematoda; D019869:Phosphatidylinositol 3-Kinases / Q000737:chemistry / Q000378:metabolism*; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D011487:Protein Conformation; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism; D017433:Protein Structure, Secondary; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D019869:Phosphatidylinositol 3-Kinases; D018129:Phosphatidylinositol Phosphates; D011494:Protein Kinases; C055525:phosphatidylinositol 3-phosphate; C492139:PIKFYVE protein, human