title: Liver tissue oxygenation as measured by near-infrared spectroscopy in the critically ill child in correlation with central venous oxygen saturation.
abstract: OBJECTIVE
  To evaluate the clinical usefulness of near-infrared spatially resolved spectroscopic quantitative assessment of liver tissue oxygenation for simple, non-invasive estimation of global tissue oxygenation in critically ill neonates and children.
  
  
  METHODS
  Prospective observational clinical study.
  
  
  METHODS
  A tertiary multidisciplinary neonatal and paediatric intensive care unit (23 beds).
  
  
  METHODS
  One hundred neonates and children consecutively admitted to the paediatric intensive care unit.
  
  
  RESULTS
  Near-infrared spectroscopic single-point assessment of liver tissue oxygenation index (TOI(Liver)) was compared with global tissue oxygenation as measured by central venous oxygen saturation (SvO(2)) and derived haemodynamic parameters. Data were compared using linear and multiple regression analysis. Overall correlation between TOI(Liver)and SvO(2) was good ( r=0.72, p<0.0001). Multivariable regression revealed that SvO(2) alone explained 51% of the observed variance of TOI(Liver). However, our data demonstrated large inter-individual differences between SvO(2) and TOI(Liver) values.
  
  
  CONCLUSIONS
  Near-infrared spatially resolved spectroscopic quantitative measurement of liver tissue oxygenation correlates well with SvO(2) in critically ill neonates and children. Large inter-individual SvO(2) to TOI(Liver) differences may prevent its use for non-invasive single-point estimation of global tissue oxygenation. Further clinical studies are required to validate the method with other regional and global haemodynamic parameters and to evaluate its clinical use for continuous non-invasive haemodynamic monitoring.
authors.affiliation: Clinic of Neonatology, University Hospital, Rämistrasse 100, 8091 Zurich, Switzerland.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Schulz
authors.forename: Markus
authors.initials: M
authors.lastname: Weiss
authors.forename: Urs
authors.initials: U
authors.lastname: Bauersfeld
authors.forename: Jan
authors.initials: J
authors.lastname: Teller
authors.forename: Daniel
authors.initials: D
authors.lastname: Haensse
authors.forename: Hans Ulrich
authors.initials: HU
authors.lastname: Bucher
authors.forename: Oskar
authors.initials: O
authors.lastname: Baenziger
mesh_terms: D002405:Catheterization, Central Venous; D016638:Critical Illness; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008099:Liver / Q000378:metabolism*; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D010100:Oxygen