title: Synthesis and preliminary biological assessments of RGD bearing biocompatible telomers.
abstract: Work reported herein deals with the synthesis and preliminary biological assessments of a new class of biocompatible telomeric carriers bearing peptidic RGDSK sequences as tumor cell targeting and tyrosine moieties labelled with 125I as in vivo probe. The radioactivity levels obtained in several tissues, after the intravenous injections of these telomers in mice bearing grafted B16 syngenic melanoma showed that the addition of a RGD residue to a telomeric structure confers it an increased affinity for the highly vascularized zone surrounding the tumor.
authors.affiliation: Laboratoire de Chimie Bioorganique et des Systèmes Moléculaires Vectoriels, Faculté des Sciences, 33, rue Louis Pasteur, 84000 Avignon, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Jasseron
authors.forename: Christiane
authors.initials: C
authors.lastname: Contino-Pépin
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Maurizis
authors.forename: Maryse
authors.initials: M
authors.lastname: Rapp
authors.forename: Bernard
authors.initials: B
authors.lastname: Pucci
mesh_terms: D000107:Acetylation; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers; D007457:Iodine Radioisotopes; D008297:Male; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging*; D051379:Mice; D008810:Mice, Inbred C57BL; D009842:Oligopeptides / Q000008:administration & dosage / Q000138:chemical synthesis*; D011877:Radionuclide Imaging; D016615:Telomere / Q000737:chemistry*; D014018:Tissue Distribution
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D007457:Iodine Radioisotopes; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid