[30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway].
The bradykinin B2 receptor which belongs to the G-protein-coupled receptor (GPCR) family is known for its proliferative effects. The mitogenic signalling pathways used are "classical" pathways for GPCRs. Recent data from our laboratory show that bradykinin can also induce anti-mitogenic effects in proliferating cells using an "alternative" signal transduction pathway involving a protein tyrosine phosphatase. Besides this alternative signalling pathway for the B2 receptor, a novel concept of GPCR signalling is described.
Duchêne
J
J
INSERM U 388 Pharmacologie moléculaire et phsiopathologie rénale, CHU Rangueil, Toulouse. jean-pierre.girolami@toulouse.inserm.fr.
Schanstra
J
J
Cellier
E
E
Bascands
J L
JL
Girolami
Jean-Pierre
JP
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology / Q000502:physiology*; D016466:CHO Cells; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D006224:Cricetinae; D019204:GTP-Binding Proteins / Q000502:physiology; D005920:Glomerular Mesangium / Q000187:drug effects / Q000502:physiology; D006801:Humans; D053614:Janus Kinase 2; D020935:MAP Kinase Signaling System / Q000187:drug effects / Q000502:physiology; D008954:Models, Biological; D019001:Nitric Oxide Synthase / Q000502:physiology; D052250:Nitric Oxide Synthase Type III; D009928:Organ Specificity; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D010766:Phosphorylation; D011493:Protein Kinase C / Q000502:physiology; D011499:Protein Processing, Post-Translational; D017027:Protein Tyrosine Phosphatases / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011518:Proto-Oncogene Proteins; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin / Q000819:agonists / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D014162:Transfection; D010738:Type C Phospholipases / Q000502:physiology
D011518:Proto-Oncogene Proteins; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin; D011993:Recombinant Fusion Proteins; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; D019869:Phosphatidylinositol 3-Kinases; D011505:Protein-Tyrosine Kinases; C507924:JAK2 protein, human; D053614:Janus Kinase 2; D011493:Protein Kinase C; D017027:Protein Tyrosine Phosphatases; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D001920:Bradykinin