title: Plasminogen activator inhibitor 1: physiological and pathophysiological roles.
abstract: Plasminogen activator inhibitor 1 (PAI-1) inhibits plasminogen activators (u-PA and t-PA) by forming stable complexes endocytosed via a low-density lipoprotein receptor superfamily member-dependent mechanism. PAI-1 circulates actively in plasma and latently in platelets but is also secreted and deposited into the matrix by several cells, where it participates in tissue repair processes.
authors.affiliation: Department of Vascular Biology and Thrombosis Research, University of Vienna, A-1090 Vienna, Austria. bernd.blinder@univie.ac.at
authors.forename: Bernd R
authors.initials: BR
authors.lastname: Binder
authors.forename: Günter
authors.initials: G
authors.lastname: Christ
authors.forename: Florian
authors.initials: F
authors.lastname: Gruber
authors.forename: Nelly
authors.initials: N
authors.lastname: Grubic
authors.forename: Peter
authors.initials: P
authors.lastname: Hufnagl
authors.forename: Michael
authors.initials: M
authors.lastname: Krebs
authors.forename: Judit
authors.initials: J
authors.lastname: Mihaly
authors.forename: Gerald W
authors.initials: GW
authors.lastname: Prager
mesh_terms: D020141:Hemostatic Disorders / Q000503:physiopathology*; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000737:chemistry / Q000502:physiology*; D014652:Vascular Diseases / Q000503:physiopathology*
chemical_list: D017395:Plasminogen Activator Inhibitor 1