title: The phosphatidylinositol 3-phosphate-binding FYVE finger.
abstract: The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions.
authors.affiliation: Department of Biochemistry, The Norwegian Radium Hospital, Oslo, Norway. h.a.stenmark@farmasi.uio.no
authors.forename: Harald
authors.initials: H
authors.lastname: Stenmark
authors.forename: Rein
authors.initials: R
authors.lastname: Aasland
authors.forename: Paul C
authors.initials: PC
authors.lastname: Driscoll
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009348:Nematoda; D019869:Phosphatidylinositol 3-Kinases / Q000737:chemistry / Q000378:metabolism*; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D011487:Protein Conformation; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism; D017433:Protein Structure, Secondary; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D018129:Phosphatidylinositol Phosphates; D011494:Protein Kinases; C055525:phosphatidylinositol 3-phosphate; C492139:PIKFYVE protein, human