title: Spatial distribution and cell kinetics of the glands in the human esophageal mucosa.
abstract: The glands in the human esophageal mucosa have been considered rudimentary, and have been poorly studied. Only recently, their role in the defense of the esophageal mucosa in gastroesophageal reflux disease has been put in evidence. In the present study, the presence of the different esophageal gland types was observed in 82 necropsy specimens. A precise topographical study was possible in 15 specimens. Cell proliferation parameters, namely DNA synthesis and mitotic index values in the squamous epithelium and in the esophageal glands were measured in 8 patients undergoing a surgical palliative esophagectomy, after in vivo labelling with bromodeoxyuridine. Upper mucosal, lower mucosal, and submucosal glands were observed in respectively 3.7%, 87% and 99% of the 82 esophageal specimens. Our topographical analysis showed that the upper mucosal glands, lower mucosal glands, and submucosal glands are occupying respectively 0.02%, 2.61%, and 3.96% of the esophageal surface. DNA synthesis and mitotic index values in the progenitor zone of the squamous epithelium were respectively 7.91% and 0.81%, whereas the proliferative activity in the glands was extremely low. The labelling index In the excretory ducts of the glands was only 0.07%, while no labelled cells nor mitotic figures were observed in any of the glandular acini.
authors.affiliation: Department of Experimental Surgery, Free University Brussels, Belgium. yvnieuwe@heel.vub.ac.be
authors.forename: Y
authors.initials: Y
authors.lastname: van Nieuwenhove
authors.forename: H
authors.initials: H
authors.lastname: Destordeur
authors.forename: G
authors.initials: G
authors.lastname: Willems
mesh_terms: D000328:Adult; D000368:Aged; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002455:Cell Division; D004947:Esophagus / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D001973:Bromodeoxyuridine