title: Pyrano-isoflavones with erectile-dysfunction activity from Eriosema kraussianum.
abstract: Five pyrano-isoflavones have been isolated from the rootstock of Eriosema kraussianum N. E. Br (Papilionaceae). Spectral data and single crystal X-ray analyses were used for structural elucidation. The most active of the compounds had an activity of 75% of that found in Viagra in the erectile dysfunction test on rabbit penile smooth muscle.
authors.affiliation: School of Chemical and Physical Sciences, University of Natal, P. Bag X01, Scottsville, 3209, Pietermaritzburg, South Africa. drewes@nu.ac.za
authors.forename: Siegfried E
authors.initials: SE
authors.lastname: Drewes
authors.forename: Marion M
authors.initials: MM
authors.lastname: Horn
authors.forename: Orde Q
authors.initials: OQ
authors.lastname: Munro
authors.forename: Jabu T B
authors.initials: JT
authors.lastname: Dhlamini
authors.forename: J J Marion
authors.initials: JJ
authors.lastname: Meyer
authors.forename: N Christopher
authors.initials: NC
authors.lastname: Rakuambo
mesh_terms: D000818:Animals; D001681:Biological Assay; D018360:Crystallography, X-Ray; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D023421:Models, Animal; D010410:Penile Erection / Q000187:drug effects*; D027805:Phaseolus / Q000737:chemistry*; D011817:Rabbits
chemical_list: D007529:Isoflavones; C465002:kraussianone 1