[Efficiency of Diprim for the restoration of the functional status of the liver after its damage by ethanol poisoning].
The effects of Diprim, a natural polyphenol complex isolated from Amur grapes crest, on lipid metabolism, lipid peroxidation (LPO), and antioxidative system of the liver were studied in ethanol-treated rats. Diprim injected to animals during ethanol abstinence arrested stress and thus inhibited lipolysis in fatty tissue and prevented triglyceride accumulation in the liver. Ethanol-suppressed metabolic reactions of the liver concerned with the synthesis of phospholipid fractions (phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine) were restored. Diprim promoted inhibition of LPO processes (the level of malonic dialdehyde decreased) and a pronounced glutathione-saving effect, which is largely due to its components--polyphenols which capture free radicals.
Kushnerova
N F
NF
Sprygin
V G
VG
Fomenko
S E
SE
Gordeĭchuk
T N
TN
Rakhmanin
Iu A
IuA
D000818:Animals; D002392:Catechin / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury; D000431:Ethanol / Q000009:adverse effects*; D005419:Flavonoids / Q000737:chemistry / Q000627:therapeutic use*; D047348:Hydrolyzable Tannins; D008031:Lignin / Q000627:therapeutic use; D008107:Liver Diseases / Q000188:drug therapy*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013634:Tannins / Q000627:therapeutic use
C464424:Diprim; D005419:Flavonoids; D047348:Hydrolyzable Tannins; D013634:Tannins; D000431:Ethanol; D002392:Catechin; D008031:Lignin