title: Is magnetic resonance imaging texture analysis a useful tool for cell therapy in vivo monitoring?
abstract: Assessment of anti-tumor treatment efficiency is usually done by measuring tumor size. Treatment may however induce changes in the tumor other than tumor size. Magnetic Resonance Imaging Texture Analysis (MRI-TA) is presently used to follow activated lymphocyte cell therapy. We used a 7T microimager to acquire high-resolution MR images of an experimental liver metastasis from colon carcinoma in rats treated (n = 4) or not (n = 3) with a cell therapy product. MRI-TA was then performed with Linear Discriminant Analysis and showed: i) a significant variation of tumor texture with tumor growth and ii) a significant modification in the texture of tumors treated with activated lymphocytes compared with untreated tumors. T2-weighted images or volume calculation did not evidence any difference. MRI-TA appears as a promising method for early detection and follow-up of response to cell therapy.
authors.affiliation: Laboratoire de Résonance Magnétique en Biologie et Médecine & IFR91 Imagerie Métabolique et Modélisation, Faculté de Médecine, Rennes, France. pierre-antoine.eliat@univ-rennes1.fr
authors.forename: P A
authors.initials: PA
authors.lastname: Eliat
authors.forename: D
authors.initials: D
authors.lastname: Lechaux
authors.forename: A
authors.initials: A
authors.lastname: Gervais
authors.forename: N
authors.initials: N
authors.lastname: Rioux-Leclerc
authors.forename: F
authors.initials: F
authors.lastname: Franconi
authors.forename: L
authors.initials: L
authors.lastname: Lemaire
authors.forename: L
authors.initials: L
authors.lastname: Dazord
authors.forename: V
authors.initials: V
authors.lastname: Catros-Quemener
authors.forename: J D
authors.initials: JD
authors.lastname: de Certaines
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000556:secondary* / Q000628:therapy*; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D003110:Colonic Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D016219:Immunotherapy, Adoptive / Q000379:methods*; D008114:Liver Neoplasms, Experimental / Q000276:immunology / Q000556:secondary* / Q000628:therapy*; D008213:Lymphocyte Activation / Q000276:immunology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015166:Monitoring, Immunologic / Q000379:methods; D008991:Monitoring, Physiologic / Q000379:methods; D051381:Rats