title: Influence of Helicobacter pylori infection on the prevalence of reflux esophagitis in Japanese patients.
abstract: OBJECTIVE
  Reflux esophagitis is caused by esophageal motor dysfunction in patients with sufficient gastric acid secretion. Helicobacter pylori causes atrophic gastritis and influences gastric acid secretion. Hiatus hernia (HH) of the esophagus causes motor dysfunction in the lower esophagus. Therefore, this study aimed to test whether H. pylori infection, gastric mucosal atrophy and HH are predictive factors for reflux esophagitis.
  
  
  METHODS
  Helicobacter pylori infection was examined in 781 patients by the measurement of serum immunoglobulin (Ig)G antibody, bacteriological culture and histological examination of biopsy specimens. The prevalence of HH, endoscopically identified gastric mucosal atrophy (closed- or open-type) and reflux esophagitis were investigated by reviewing endoscopic films. Investigated patients were divided into three age groups, under 49, 50-69, and over 70 years. The prevalence of esophagitis, H. pylori infection, gastric mucosal atrophy, and HH were compared to identify the possible predictive factors for reflux esophagitis by using logistic regression analysis.
  
  
  RESULTS
  Sixty-nine patients with reflux esophagitis were found among the 781 investigated cases. The odds ratios of negative H. pylori infection, endoscopically identified closed-type gastric mucosal atrophy, and HH for the prevalence of reflux esophagitis were 1.342, 1.751 and 5.527, respectively. These results indicated that the presence of H. pylori infection was only a weak negative risk factor, and that HH was the most reliable endoscopic predictive factor for reflux esophagitis.
  
  
  CONCLUSIONS
  Helicobacter pylori infection is a weak negative risk factor for the prevalence of reflux esophagitis, while HH is the most reliable predictive factor.
authors.affiliation: Department of Internal Medicine II, Shimane Medical University, Izumo-shi, Shimane, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Fujishiro
authors.forename: K
authors.initials: K
authors.lastname: Adachi
authors.forename: A
authors.initials: A
authors.lastname: Kawamura
authors.forename: T
authors.initials: T
authors.lastname: Katsube
authors.forename: M
authors.initials: M
authors.lastname: Ono
authors.forename: M
authors.initials: M
authors.lastname: Yuki
authors.forename: K
authors.initials: K
authors.lastname: Amano
authors.forename: S
authors.initials: S
authors.lastname: Ishihara
authors.forename: Y
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D000368:Aged; D004942:Esophagitis, Peptic / Q000453:epidemiology* / Q000382:microbiology*; D005260:Female; D016481:Helicobacter Infections; D016480:Helicobacter pylori; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D015995:Prevalence