title: Activity of BMS-284756, a novel des-fluoro(6) quinolone, against Staphylococcus aureus, including contributions of mutations to quinolone resistance.
abstract: The in vitro activity of BMS-284756 against 602 Staphylococcus aureus isolates, including 152 that were both methicillin and ciprofloxacin resistant (MIC > or = 4 microg/ml), was determined. For ciprofloxacin-susceptible and nonsusceptible isolates, the MICs at which 50% of organisms were inhibited were 0.015 and 2 microg/ml and the MICs at which 90% of organisms were inhibited were 0.03 and 4 microg/ml, respectively.
authors.affiliation: Department of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital, Toronto, Ontario, Canada. dlow@mtsinai.on.ca
authors.forename: D E
authors.initials: DE
authors.lastname: Low
authors.forename: M
authors.initials: M
authors.lastname: Muller
authors.forename: C L
authors.initials: CL
authors.lastname: Duncan
authors.forename: B M
authors.initials: BM
authors.lastname: Willey
authors.forename: J C
authors.initials: JC
authors.lastname: de Azavedo
authors.forename: A
authors.initials: A
authors.lastname: McGeer
authors.forename: B N
authors.initials: BN
authors.lastname: Kreiswirth
authors.forename: S
authors.initials: S
authors.lastname: Pong-Porter
authors.forename: D J
authors.initials: DJ
authors.lastname: Bast
mesh_terms: D019943:Amino Acid Substitution; D000890:Anti-Infective Agents / Q000494:pharmacology*; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000037:antagonists & inhibitors / Q000235:genetics; D004269:DNA, Bacterial / Q000187:drug effects / Q000235:genetics; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D006801:Humans; D007211:Indoles; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000235:genetics*; D015363:Quinolones; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics*; D059005:Topoisomerase II Inhibitors
chemical_list: D000890:Anti-Infective Agents; D004269:DNA, Bacterial; D024841:Fluoroquinolones; D007211:Indoles; D015363:Quinolones; D059005:Topoisomerase II Inhibitors; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase; C419689:garenoxacin