Brain TXA(2) and PGI(2) levels after head injury with secondary insults.
OBJECTIVE: The brain TXA(2) and PGI(2) levels in a new rodent model of impact acceleration diffuse brain injury alone and with hypotention and hyperthermia in combination were observed to look into the relationship between TXA(2), PGI(2) levels and different types of head injury. METHODS: Thirty-two SD rats were randomized into sham, head injury alone, secondary insult alone and head injury with secondary insult groups. At 4 hours after injury or experiment, all the rats were decapitated and their brains were sampled for radioimmunoassay (RIA) measurement. RESULTS: Compared with that of sham group there were no changes in TXA(2) and PGI(2) levels in injury alone group while there was a significant augmentation in PGI(2) level in insult alone group. Both TXA(2) and PGI(2) level in injury with secondary insult group increased significantly in comparison with that of sham at 4 hours postimpact. CONCLUSIONS: PGI(2) providing energy and precursors to the injured tissue and producing some vasoactive arachidonic products, especially TXA(2), is closely connected to the severity of brain damage.
Fei
Zhou
Z
Department of Neurosurgery, Xijing Hospital, Xi'an 710032, China.
Zhang
Xiang
X
Song
Shaojun
S
Piper
I R
IR
Thomson
D
D
Miller
J D
JD