Lidocaine-dependent early infantile status epilepticus with highly suppressed EEG.
We report an early infantile patient characterized by intractable hyponatremia, progressive megalencephaly, and epileptic seizures with an EEG pattern that alternated between interictal low-voltage background and ictal burst activity. Repeatedly all the abnormal findings improved in a lidocaine-dependent manner. Given the pharmacologic mechanisms of lidocaine as a sodium channel blocker, we speculate that our patient had a sodium channel dysfunction.
Sawaishi
Yukio
Y
Department of Pediatrics, Akita University School of Medicine, Japan. sawaishi@ped.med.akita-u.ac.jp
Yano
Tamami
T
Enoki
Masamichi
M
Takada
Goro
G
D004569:Electroencephalography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D026941:Sodium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D013226:Status Epilepticus / Q000188:drug therapy* / Q000503:physiopathology*; D016896:Treatment Outcome
D026941:Sodium Channel Blockers; D008012:Lidocaine