Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells.
The gene expression patterns of primordial germ cells (PGCs) and embryonic stem cells were analyzed by a modified serial analysis of gene expression. During the process, we cloned a novel gene, PGC7, which was preferentially expressed in PGCs. Immunohistochemical analysis revealed that PGC7 was specifically expressed in early pre-implantation embryos, PGCs and oocytes. These results suggest that PGC7 might play an important role in the development of PGCs and oocytes.
Sato
Masatake
M
Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka Suita 565-0871, Japan.
Kimura
Tohru
T
Kurokawa
Ken
K
Fujita
Yukiko
Y
Abe
Koichiro
K
Masuhara
Masaaki
M
Yasunaga
Teruo
T
Ryo
Akihide
A
Yamamoto
Mikio
M
Nakano
Toru
T
D000595:Amino Acid Sequence; D000818:Animals; D001755:Blastocyst / Q000378:metabolism*; D015152:Blotting, Northern; D015153:Blotting, Western; D002868:Chromosomal Proteins, Non-Histone; D018076:DNA, Complementary / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009865:Oocytes / Q000378:metabolism; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*; D013997:Time Factors; D014018:Tissue Distribution
D002868:Chromosomal Proteins, Non-Histone; D018076:DNA, Complementary; C466105:DPPA3 protein, human; D011506:Proteins