Heterochromatin: new possibilities for the inheritance of structure.
Significant portions of the eukaryotic genome are heterochromatic, made up largely of repetitious sequences and possessing a distinctive chromatin structure associated with gene silencing. New insights into the form of packaging, the associated histone modifications, and the associated nonhistone chromosomal proteins of heterochromatin have suggested a mechanism for providing an epigenetic mark that allows this distinctive chromatin structure to be maintained following replication and to spread within a given domain.
Grewal
Shiv I S
SI
Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, New York 11724, USA. grewal@cshl.org
Elgin
Sarah C R
SC
D000818:Animals; D000090266:Chromobox Protein Homolog 5; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology; D004330:Drosophila / Q000235:genetics / Q000502:physiology; D005656:Fungal Proteins / Q000502:physiology; D020868:Gene Silencing / Q000502:physiology; D006570:Heterochromatin / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D006657:Histones / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D012568:Schizosaccharomyces / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
D002868:Chromosomal Proteins, Non-Histone; D005656:Fungal Proteins; D006570:Heterochromatin; D006657:Histones; C075111:SWI6 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D000090266:Chromobox Protein Homolog 5