title: N-alkylaminoacids and their derivatives interact with melanocortin receptors.
abstract: Thirty four N-alkylaminoacids (Arg, Trp, Nal, Pro, Hyp, L and D) and derivatives were prepared by a process that included reductive alkylation of the amino function. Both solid phase and solution synthesis was used. Title substances displayed binding activity on melanocortin receptors MC(1,3-5) reaching the low micromolar range.
authors.affiliation: Department of Pharmaceutical Biosciences, Division of Pharmacology, Uppsala Biomedical Center, PO Box 591, Uppsala University, S-751 24 Uppsala, Sweden.
authors.forename: Felikss
authors.initials: F
authors.lastname: Mutulis
authors.forename: Ilze
authors.initials: I
authors.lastname: Mutule
authors.forename: Jarl E S
authors.initials: JE
authors.lastname: Wikberg
mesh_terms: D000478:Alkylation; D000596:Amino Acids / Q000378:metabolism*; D001667:Binding, Competitive; D002460:Cell Line; D006801:Humans; D007457:Iodine Radioisotopes; D008956:Models, Chemical; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011485:Protein Binding; D044104:Receptor, Melanocortin, Type 3; D044105:Receptor, Melanocortin, Type 4; D018043:Receptors, Corticotropin / Q000378:metabolism*; D044101:Receptors, Melanocortin
chemical_list: D000596:Amino Acids; D007457:Iodine Radioisotopes; D044104:Receptor, Melanocortin, Type 3; D044105:Receptor, Melanocortin, Type 4; D018043:Receptors, Corticotropin; D044101:Receptors, Melanocortin; C086971:melanocortin 5 receptor