Fourteen-member macrolides suppress interleukin-8 production but do not promote apoptosis of activated neutrophils.
A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils. These data suggest that 14-member macrolides achieve clinical efficacy for chronic airway diseases partly by suppressing IL-8 production by activated neutrophils, but not by enhancing apoptosis in these cells.
Tsuchihashi
Yoshiko
Y
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Oishi
Kazunori
K
Yoshimine
Hiroyuki
H
Suzuki
Shoichi
S
Kumatori
Atsushi
A
Sunazuka
Toshiaki
T
Omura
Satoshi
S
Matsushima
Kouji
K
Nagatake
Tsuyoshi
T
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D016209:Interleukin-8 / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D007976:Leupeptins / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D018942:Macrolides; D018375:Neutrophil Activation; D009504:Neutrophils / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D015853:Cysteine Proteinase Inhibitors; D016209:Interleukin-8; D007976:Leupeptins; D008070:Lipopolysaccharides; D018942:Macrolides; D003907:Dexamethasone; C072553:benzyloxycarbonylleucyl-leucyl-leucine aldehyde