title: [Validation of the optimal concentration of Metrogil-denta preparation in the treatment of periodontal inflammations].
abstract: Fifty-two patients (22-68 years) with chronic generalized periodontitis of different severity and 223 with fulminant severe periodontitis were observed. The bacteriostatic and bactericidal effects of Metrogil-denta depended on the severity of periodontal involvement and metronidasole concentration in the drug. The maximum bacteriostatic effect was observed at 20-25% and the maximum bactericidal effect at 25% concentration of metronidasole in the preparation irrespective of periodontitis severity.
authors.forename: A I
authors.initials: AI
authors.lastname: Grudianov
authors.forename: N A
authors.initials: NA
authors.lastname: Dmitrieva
authors.forename: V V
authors.initials: VV
authors.lastname: Ovchinnikova
mesh_terms: D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D010518:Periodontitis / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; D008795:Metronidazole