Neuregulin signaling via erbB receptor assemblies in the nervous system.
Neuregulins (NRG) play important roles in the development, maintenance, and repair of the nervous system, with influences on neuronal migration, synaptogenesis, receptor subunit composition, and the proliferation/survival of oligodendrocytes and Schwann cells. However, the precise detail of how the NRGs signal through ErbB receptors, particularly at central synapses, is incomplete. The receptor kinase domain provides sites for association with adaptor proteins. In addition, evidence from recent reports suggests that ErbB2/4 receptors, through their C-terminal amino acids, can form specific associations with scaffolding proteins. The existence of such assemblies expands the range of signaling cascades available to the NRGs.
Murphy
Sean
S
Institute of Cell Signalling, Medical School, Queen's Medical Centre, University of Nottingham, UK. sean.murphy@nottingham.ac.uk
Krainock
Randy
R
Tham
Muly
M
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D002490:Central Nervous System / Q000502:physiology*; D066246:ErbB Receptors / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D018345:Mice, Knockout; D008818:Mice, Neurologic Mutants; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000502:physiology*; D020880:Neuregulins / Q000235:genetics / Q000502:physiology*; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000502:physiology; D052247:Nitric Oxide Synthase Type II; D017434:Protein Structure, Tertiary; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000737:chemistry / Q000502:physiology*; D020893:Receptor, ErbB-3 / Q000502:physiology; D066247:Receptor, ErbB-4; D012583:Schwann Cells / Q000378:metabolism; D013569:Synapses / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D066246:ErbB Receptors; D047908:Intracellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; D020880:Neuregulins; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D018719:Erb-b2 Receptor Tyrosine Kinases; D020893:Receptor, ErbB-3; D066247:Receptor, ErbB-4; C413364:ERBIN protein, human; C498804:Erbb2ip protein, mouse; C033652:postsynaptic density proteins; C496319:NOS2 protein, human; C496317:Nos2 protein, mouse; C587689:ERBB4 protein, human; C587690:Erbb4 protein, mouse