title: [Multiple intracranial and intraspinal meningiomas successively discovered in the absence of neurofibromatosis: 2 cases].
abstract: Multiple meningiomas in different neuroaxial compartments are quite rare. We describe the case of a 44-year-old woman who developed three intracranial meningiomas and 8 years later a T3 dorsal meningioma. Histologically, the frontal and dorsal tumors appeared as benign psammomatouss meningiomas. Both tumors were removed successfully. The second patient was a 31-year-old woman who developed right benign fronto-parietal transitional meningioma. She presented local and spheno-orbital recurrences, then a lombo-sacral lesion. The histological picture worsened from benign to malignant with multiple recurrences. Several mechanisms could account for multiple meningiomas. Such meningiomas could arise from a single primary tumor via subarachnoidal spread of a benign or malignant nature. Alternatively, they could be atypical forms of neurofibromatosis type 2 or tumors with a multifocal origin.
authors.affiliation: Service de Neurologie, HIA Desgenettes, 108, bd Pinel 69275 Lyon.
authors.forename: A
authors.initials: A
authors.lastname: Drouet
authors.forename: L
authors.initials: L
authors.lastname: Guilloton
authors.forename: I
authors.initials: I
authors.lastname: Pelissou-Guyotat
authors.forename: G
authors.initials: G
authors.lastname: Saint-Pierre
authors.forename: C
authors.initials: C
authors.lastname: Ribot
authors.forename: M
authors.initials: M
authors.lastname: Sindou
authors.forename: R
authors.initials: R
authors.lastname: Deruty
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008579:Meningioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D016518:Neurofibromatosis 2 / Q000175:diagnosis*; D010296:Parietal Lobe / Q000473:pathology / Q000601:surgery; D013116:Spinal Cord / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed