Do the CK18 related proteins change in general in epithelial cancers?
The modulation of cytokeratin 18 during tumor transformation in hepatoma had been previously recognized through a series of biochemical and immunological approaches. Expression of cytokeratin 18 in transitional cell carcinoma comparing with hepatoma was investigated using the hepatoma transformation model. CK18 related molecules were found. In the present study, we design various epithelial cancers with the same model. CK18 related molecules were all evident. Therefore, we suggest that CK18 related proteins would play an important role in tumorigenesis of epithelial cancers.
Pei
R J
RJ
Department of Pathology, School of Medicine, China Medical College, Taichung, Taiwan.
Liu
Y H
YH
Su
B
B
Yeh
C C
CC
Lee
K Y
KY
Yeh
K T
KT
Hsu
Y H
YH
Ho
C C
CC
Lai
Y S
YS
D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D007633:Keratins / Q000737:chemistry / Q000378:metabolism*; D008113:Liver Neoplasms / Q000209:etiology / Q000378:metabolism; D008297:Male; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000737:chemistry / Q000378:metabolism*; D009375:Neoplasms, Glandular and Epithelial / Q000209:etiology / Q000378:metabolism*
D009363:Neoplasm Proteins; D007633:Keratins