title: Is there a BOLD response of the visual cortex on stimulation of the vision-related acupoint GB 37?
abstract: OBJECTIVE
  To determine whether or not acupuncture of guangming (GB 37) produces a significant response of the visual cortex detectable by means of functional magnetic resonance imaging (fMRI).
  
  
  METHODS
  This study investigates the activation of the visual cortex elicited by a soft and an intensified stimulation of GB 37, an acupoint documented to influence vision-related disorders. Three different paradigms were carried out to detect any possible modulation of the Blood Oxygenation Level Dependent (BOLD)-response in the visual cortex to visual stimulation through acupuncture.
  
  
  RESULTS
  The percentage signal changes in the visual stimulation cycles did not significantly differ before vs. during acupuncture.
  
  
  CONCLUSIONS
  Whereas no BOLD-response correlating with acupuncture was detected in the visual cortex, BOLD-signal-changes in response to needle twisting were detected in different cortical areas. Further studies are necessary to clarify whether these clusters correlate to inevitable somatosensory stimulation accompanying acupuncture or represent an acupuncture-specific response.
authors.affiliation: Department of Radiology, Section of Medical Physics, University Hospital Freiburg, Freiburg, Germany. isabel_gareus@hotmail.com
authors.forename: Isabel K
authors.initials: IK
authors.lastname: Gareus
authors.forename: Michael
authors.initials: M
authors.lastname: Lacour
authors.forename: Anja-Carina
authors.initials: AC
authors.lastname: Schulte
authors.forename: Juergen
authors.initials: J
authors.lastname: Hennig
mesh_terms: D015669:Acupuncture Points; D000328:Adult; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D014793:Visual Cortex / Q000098:blood supply* / Q000502:physiology
chemical_list: D010100:Oxygen