[Postradiation recovery of hematopoiesis in mice affected by Neogen (IEW)].
The effect of the synthetic peptide IEW (Neogen) with immunomodulating properties on postradiation recovery of haemopoiesis was investigated. We have shown that Neogen is a potential stimulator of haemopoiesis. The administration of Neogen after irradiation shortened duration of period of the recovery of the compartment of CFU-S-8 and the amount of bone marrow cells. The comparision of the effects of Neogen and GM-CSF (Leucomax) and G-CSF (Granocyte 34) have shown that the targets for these agents are probably different: polypotent CFU-S-for Neogen, and CFU-GM-for GM-CFS. Based on the results, we suggested the mechanism of Neogen effects on heamopoiesis.
Semenets
T N
TN
Medical Radiological Research Centre, Russian Academy of Medical Sciences, Obninsk, 249020 Russia.
Semina
O V
OV
Deĭgin
V I
VI
Vinogradova
Iu E
IuE
Maliutina
Ia V
IaV
Budagova
K R
KR
Shinkarkina
A P
AP
Poverennyĭ
A M
AM
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D003114:Colony-Forming Units Assay; D003627:Data Interpretation, Statistical; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects*; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D013997:Time Factors
D000276:Adjuvants, Immunologic; D003037:Cobalt Radioisotopes