title: N-arylation of primary and secondary aliphatic amines on solid supports.
abstract: A general and mild method for the N-arylation of primary and secondary aliphatic amines is reported. Copper acetate, triethylamine mediated C/N cross-coupling reaction of arylboronic acids at room temperature to solid-supported primary and secondary amines gave good to excellent yields of the desired N-arylated products.
authors.affiliation: Chemical and Physical Sciences Department, DuPont Pharmaceuticals Company, Experimental Station, P.O. Box 80500, Wilmington, Delaware 19880-0500, USA.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Combs
authors.forename: Seifu
authors.initials: S
authors.lastname: Tadesse
authors.forename: Maria
authors.initials: M
authors.lastname: Rafalski
authors.forename: Tasir S
authors.initials: TS
authors.lastname: Haque
authors.forename: Patrick Y S
authors.initials: PY
authors.lastname: Lam
mesh_terms: D000588:Amines / Q000138:chemical synthesis*; D002625:Chemistry, Organic / Q000379:methods; D020650:Combinatorial Chemistry Techniques
chemical_list: D000588:Amines