title: Squamous cell carcinoma in situ of the penis successfully treated with imiquimod 5% cream.
abstract: BACKGROUND
  Multiple treatments for squamous cell carcinoma in situ (SCCIS) of the penis have been used with variable success and morbidity. Surgery and destructive treatment modalities have significant risk of scarring, deformity, and impaired function.
  
  
  OBJECTIVE
  The purpose of this study was to determine whether topical imiquimod 5% cream is a potentially effective treatment for SCCIS of the penis and to qualify treatment associated morbidity.
  
  
  METHODS
  The case of a patient with extensive penile SCCIS is reported. The patient was treated with topical imiquimod 5%, administered daily until blistering occurred (2 cycles). Biopsy specimens were obtained to confirm tumor clearance.
  
  
  RESULTS
  One month after therapy was completed, no clinical or histologic evidence of residual tumor was found. Adverse effects of imiquimod included localized tenderness and erythema. No evidence of scarring, deformity, loss of function, or tumor recurrence was noted 18 months after treatment.
  
  
  CONCLUSIONS
  Imiquimod 5% cream may represent an alternative treatment option for SCCIS of the penis.
authors.affiliation: Washington University, St. Louis, MO 63141, USA.
authors.forename: Theresa L
authors.initials: TL
authors.lastname: Schroeder
authors.forename: Roberta D
authors.initials: RD
authors.lastname: Sengelmann
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000634:Aminoquinolines / Q000008:administration & dosage* / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001913:Bowen's Disease / Q000188:drug therapy / Q000473:pathology; D002278:Carcinoma in Situ / Q000188:drug therapy* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D000077271:Imiquimod; D008297:Male; D009824:Ointments; D010412:Penile Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D009824:Ointments; D000077271:Imiquimod