title: Catheter-related infection in patients on home parenteral nutrition: results of a prospective survey.
abstract: OBJECTIVE
  Central venous catheter (CVC) infection is the most frequent complication during home parenteral nutrition (HPN). We prospectively assessed incidence and catheter-related sepsis (CRS)-associated factors in the 42 adult patients enrolled in our HPN centre since its opening.
  
  
  METHODS
  Age, frequency of infusions, CVC type, autonomy or nurse/family aid, underlying disease, involved infectious organism(s), hospital stay, efficacy of antibiotic-lock and other infectious complications, were studied.
  
  
  RESULTS
  CRS occurred 39 times (3/1000 days of HPN). In 37/39 cases, it was proven by both peripheral and central blood cultures. In 56% of patients, clinical signs were discrete, delaying diagnosis. Individual factors like learning potency, underlying disease (especially chronic intestinal obstruction with bacterial overgrowth), and length of remaining colon and small intestine, were slightly associated with higher CRS incidence. Usually, one organism (S. epidermidis; 51%) was detected. A total of 14 CVC were immediately removed. In the others, antibiotic-lock was more effective in patients having tunnelled catheters (TC, 50%) than implanted devices (25%; P<0.05). Mean hospital stay was 22+/-15 days, which was influenced by 3 patients presenting associated osteomyelitis.
  
  
  CONCLUSIONS
  CRS incidence was 3/1000 days of HPN. Clinical symptoms were often discrete, suggesting importance of rigorous survey. Individual apprenticeship and risk for higher bacterial translocation seem associated to higher CRS incidence. CVC sterilization was more frequent in patients with TC.
authors.affiliation: Centre Agréé de Nutrition Parentérale à Domicile, Service d'Hépato-Gastroentérologie et d'Assistance Nutritive, Strasbourg Cedex, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Reimund
authors.forename: Y
authors.initials: Y
authors.lastname: Arondel
authors.forename: G
authors.initials: G
authors.lastname: Finck
authors.forename: F
authors.initials: F
authors.lastname: Zimmermann
authors.forename: B
authors.initials: B
authors.lastname: Duclos
authors.forename: R
authors.initials: R
authors.lastname: Baumann
mesh_terms: D001424:Bacterial Infections / Q000209:etiology*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016331:Parenteral Nutrition, Home / Q000009:adverse effects*; D011446:Prospective Studies; D012307:Risk Factors