mar Operon involved in multidrug resistance of Enterobacter aerogenes.
We determined the sequence of the entire marRAB operon in Enterobacter aerogenes. It is functionally and structurally analogous to the Escherichia coli operon. The overexpression of E. aerogenes MarA induces a multidrug resistance phenotype in a susceptible strain, demonstrated by a noticeable resistance to various antibiotics, a decrease in immunodetected porins, and active efflux of norfloxacin.
Chollet
Renaud
R
Enveloppe Bactérienne, Antibiotiques et Colonisation, CJF 9606-EA 2197, Facultés de Médecine et Pharmacie, Université de la Méditerranée, 13385 Marseille Cedex 05, France.
Bollet
Claude
C
Chevalier
Jacqueline
J
Malléa
Monique
M
Pagès
Jean-Marie
JM
Davin-Regli
Anne
A
D000595:Amino Acid Sequence; D000890:Anti-Infective Agents / Q000378:metabolism; D004269:DNA, Bacterial / Q000032:analysis / Q000737:chemistry; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D004591:Electrophoresis, Polyacrylamide Gel; D004754:Enterobacter / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D008969:Molecular Sequence Data; D009643:Norfloxacin / Q000378:metabolism; D009876:Operon / Q000235:genetics*; D018272:Porins / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000890:Anti-Infective Agents; D004269:DNA, Bacterial; D018272:Porins; D009643:Norfloxacin