title: Caudal Regression Syndrome in twin pregnancy with type II diabetes.
abstract: Caudal Regression Syndrome (CRS) is a rare fetal complication of diabetic pregnancy, which can result in long-term neurological, urologic, and orthopedic complications. Although the exact teratogenic mechanism is not known, hyperglycemia appears to play a crucial role as a teratogen, and therefore, stringent control of diabetes preconceptually and in early pregnancy is presumed to reduce the risk of occurrence. We report an unusual case of CRS affecting only one of a set of monozygotic twins, suggesting that as yet, unidentified factors other than hyperglycemia are included in its causation.
authors.affiliation: Department of Child Health, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK.
authors.forename: Win
authors.initials: W
authors.lastname: Zaw
authors.forename: David G
authors.initials: DG
authors.lastname: Stone
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000209:etiology; D002420:Cauda Equina / Q000002:abnormalities*; D002585:Cesarean Section; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis; D016640:Diabetes, Gestational / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D004480:Ectromelia / Q000175:diagnosis; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007866:Leg / Q000002:abnormalities*; D011247:Pregnancy; D011272:Pregnancy, Multiple; D018570:Risk Assessment; D012447:Sacrum / Q000002:abnormalities*; D013577:Syndrome; D014430:Twins, Monozygotic; D016216:Ultrasonography, Prenatal