title: Genetic admixture in three Mexican Mestizo populations based on D1S80 and HLA-DQA1 loci.
abstract: This study compares genetic polymorphisms at the D1S80 and HLA-DQA1 loci in three Mexican Mestizo populations from three large states (Nuevo León, Jalisco, and the Federal District). Allele frequency distributions are relatively homogenous in the three samples; only the Federal District population shows minor differences of the HLA-DQA1 allele frequencies compared with the other two. In terms of genetic composition, these Mestizo populations show evidence of admixture with predominantly Spanish-European (50-60%) and Amerindian (37-49%) contributions; the African contribution (1-3%) is minor. Together with the observation that in Nuevo León, the admixture estimates based on D1S80 and HLA-DQA1, are virtually the same as those reported earlier from blood group loci, suggests that DNA markers, such as D1S80 and HLA-DQA1 are useful for examining genetic homogeneity/heterogeneity across Mestizo populations of Mexico. The inverse relationship of the proportion of gene diversity due to population differences (Gst) to within population gene diversity (Hs) is also consistent with theoretical predictions, supporting the use of these markers for population genetics studies.
authors.affiliation: Departamento de Genética de Poblaciones, Centro de Investigación Biomédica del Noreste (CIBIN), Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, México.
authors.forename: Ricardo M
authors.initials: RM
authors.lastname: Cerda-Flores
authors.forename: Maria C
authors.initials: MC
authors.lastname: Villalobos-Torres
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Barrera-Saldaña
authors.forename: Lizette M
authors.initials: LM
authors.lastname: Cortés-Prieto
authors.forename: Leticia O
authors.initials: LO
authors.lastname: Barajas
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivas
authors.forename: Angel
authors.initials: A
authors.lastname: Carracedo
authors.forename: Yixi
authors.initials: Y
authors.lastname: Zhong
authors.forename: Sara A
authors.initials: SA
authors.lastname: Barton
authors.forename: Ranajit
authors.initials: R
authors.lastname: Chakraborty
mesh_terms: D004247:DNA / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D008800:Mexico; D011110:Polymorphism, Genetic
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D004247:DNA