title: The important role of operations in the management of anaplastic thyroid carcinoma.
abstract: BACKGROUND
  Anaplastic thyroid carcinoma is a rare and highly lethal neoplasm. We investigated whether operations have an impact on the survival of patients who have anaplastic carcinoma without distant metastasis.
  
  
  METHODS
  Between 1989 and 1999, 40 consecutive patients with anaplastic carcinoma, without distant metastasis at the time of presentation or during local treatment, were reviewed. The cumulative survival rates and 1-year survival rates were compared.
  
  
  RESULTS
  Eleven patients had a small focus of anaplastic carcinoma in a differentiated carcinoma, and 29 patients had ordinary anaplastic thyroid carcinoma. Surgical debulking was performed in 26 patients. Radiotherapy was used for 31 patients and chemotherapy for 19 patients. The 1-year survival rates of the patients with incidental anaplastic carcinoma, ordinary anaplastic carcinoma who underwent operations, and ordinary anaplastic carcinoma who did not undergo operations were 73%, 60%, and 21%, respectively. A significantly higher cumulative survival rate was observed in patients with incidental anaplastic carcinoma than in those with ordinary anaplastic carcinoma. A significantly better outcome was obtained by surgical debulking of ordinary anaplastic carcinoma.
  
  
  CONCLUSIONS
  Patients with incidental anaplastic carcinoma tended to have a good outcome, but some had a poor prognosis. Surgical debulking improved the outcome of patients with ordinary anaplastic carcinoma.
authors.affiliation: Surgical Division, Ito Hospital, The Department of Radiology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Kiminori
authors.initials: K
authors.lastname: Sugino
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
authors.forename: Takashi
authors.initials: T
authors.lastname: Mimura
authors.forename: Mitsuji
authors.initials: M
authors.lastname: Nagahama
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fukunari
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kubo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iwasaki
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Ito
mesh_terms: D002277:Carcinoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D016019:Survival Analysis; D013964:Thyroid Neoplasms / Q000601:surgery*