title: Role of 2-[18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) in the early assessment of response to chemotherapy in metastatic breast cancer patients.
abstract: We investigated the role of 2-[18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) in the early evaluation of response to chemotherapy in metastatic breast cancer patients. Breast cancer patients who received an epirubicin/paclitaxel--containing regimen as first-line treatment for metastatic disease were included in this study. A PET study was performed within 1 week before the start of treatment, at day 8 after the first course, and at the end of the planned program of chemotherapy. Tumor response was determined clinically and radiographically every 2 courses of treatment. Thirteen patients with metastatic breast cancer who were referred for treatment protocols with gemcitabine/epirubicin/paclitaxel or epirubicin/paclitaxel chemotherapy regimens were included in this study. All metastatic sites were easily visualized on the baseline FDG-PET images, obtained 50 to 60 minutes after tracer injection. Nine patients who completed the planned courses of chemotherapy and the FDG-PET studies were available for analysis. In the six patients who achieved a response to treatment, median glucose standard uptake value (SUV) (semiquantitative analysis) was 7.65 (range, 3.4-12.3) at baseline, 5.7 (range, 2.8-7.6) at day 8 after the first course, and 1.2 (range, 0.99-1.3) at the end of the 6 planned courses of chemotherapy. Three patients who obtained a stable disease as best response had no significant decrease in tumor glucose SUV compared to baseline levels. Qualitative visual analysis in the six responding patients showed a decrease in delineation of tumor mass from background activity soon after the first course, while the nonresponding patients had no significant modification from basal levels. Semiquantitative FDG-PET scanning of metastatic breast cancer sites showed a rapid and significant decrease in tumor glucose metabolism soon after the first course of treatment in patients who achieved a response to first-line chemotherapy. On the contrary, no significant decrease was observed in nonresponding patients.
authors.affiliation: Division of Medical Oncology, Department of Oncology, Santa Chiara Hospital, Pisa, Italy. a.gennari@do.med.unipi.it
authors.forename: A
authors.initials: A
authors.lastname: Gennari
authors.forename: S
authors.initials: S
authors.lastname: Donati
authors.forename: B
authors.initials: B
authors.lastname: Salvadori
authors.forename: A
authors.initials: A
authors.lastname: Giorgetti
authors.forename: P A
authors.initials: PA
authors.lastname: Salvadori
authors.forename: O
authors.initials: O
authors.lastname: Sorace
authors.forename: G
authors.initials: G
authors.lastname: Puccini
authors.forename: P
authors.initials: P
authors.lastname: Pisani
authors.forename: M
authors.initials: M
authors.lastname: Poli
authors.forename: D
authors.initials: D
authors.lastname: Dani
authors.forename: E
authors.initials: E
authors.lastname: Landucci
authors.forename: G
authors.initials: G
authors.lastname: Mariani
authors.forename: P F
authors.initials: PF
authors.lastname: Conte
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000473:pathology*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016903:Drug Monitoring / Q000379:methods* / Q000592:standards; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality / Q000556:secondary; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality / Q000556:secondary; D017239:Paclitaxel / Q000008:administration & dosage; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D012074:Remission Induction; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality / Q000556:secondary; D016019:Survival Analysis; D013997:Time Factors; D014055:Tomography, Emission-Computed / Q000379:methods* / Q000592:standards; D016896:Treatment Outcome; D000093542:Gemcitabine
chemical_list: D019275:Radiopharmaceuticals; D003841:Deoxycytidine; D019788:Fluorodeoxyglucose F18; D015251:Epirubicin; D005947:Glucose; D017239:Paclitaxel; D000093542:Gemcitabine