Prevention of experimental autoimmune cardiomyopathy in rabbits by receptor blockers.
We investigated the effects of beta1-adrenoceptor blockade and M2-muscarinic receptor antagonist in rabbits which have developed dilated cardiomyopathy-like changes after immunization with the peptides from the second extracellular loop of human beta1-adrenoceptor (beta1-peptide) and M2-muscarinic receptor (M2-peptide). Ten rabbits, which were immunized with beta1-peptide once a month for one year, were treated with bisoprolol and 10 rabbits, which were immunized with M2-peptide, were treated with otenzepad. Although both groups treated with receptor blockade or antagonist showed an increased titer of anti-beta1-adrenoceptor or anti-M2-muscarinic receptor antibodies, myocardial damages were markedly less than those in beta1-peptide- or M2-peptide-immunized rabbits. This study indicates that anti-beta1-adrenoceptor and anti-M2-muscarinic receptor antibodies are of pathogenic importance in the development of human dilated cardiomyopathy, and that beta-adrenoceptor blockade, bisoprolol, and M2-muscarinic receptor antagonist, otenzepad, might be clinically useful for treatment of dilated cardiomyopathy.
Matsui
S
S
Department of Cardiology, Kanazawa Medical University, Uchinada, Ishikawa, Japan. matsui@kanazawa-med.ac.jp
Fu
M L
ML
D058671:Adrenergic beta-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000517:prevention & control*; D017298:Bisoprolol / Q000494:pharmacology*; D009202:Cardiomyopathies / Q000276:immunology* / Q000517:prevention & control*; D004195:Disease Models, Animal; D018727:Muscarinic Antagonists / Q000494:pharmacology; D010890:Pirenzepine / Q000031:analogs & derivatives / Q000494:pharmacology; D011817:Rabbits; D018342:Receptors, Adrenergic, beta-1 / Q000276:immunology; D011976:Receptors, Muscarinic / Q000276:immunology
D058671:Adrenergic beta-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists; D018727:Muscarinic Antagonists; D018342:Receptors, Adrenergic, beta-1; D011976:Receptors, Muscarinic; D010890:Pirenzepine; C048593:otenzepad; D017298:Bisoprolol