Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass.
Phosphatidylinositol 3-kinase lipid products and the Rho GTPases play a central role in transmitting information from chemotactic receptors to the effectors of cell polarity, and recent advances in the field have allowed us to understand these roles more clearly. Emergent properties of positive and negative regulation of these molecules may account for the establishment of cell polarity during chemotaxis for a wide range of cells from Dictyostelium to fibroblasts to neutrophils.
Weiner
Orion D
OD
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue/C-1, 502, Boston, MA 02115, USA. orion_weiner@hms.harvard.edu
D000818:Animals; D016764:Cell Polarity / Q000502:physiology*; D002633:Chemotaxis / Q000502:physiology*; D006801:Humans; D008246:Lysophospholipids; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
D008246:Lysophospholipids; D010982:Platelet-Derived Growth Factor; C060506:sphingosine 1-phosphate; D019869:Phosphatidylinositol 3-Kinases; D020741:rho GTP-Binding Proteins; D013110:Sphingosine