Temporary auxiliary liver transplantation from a living donor to an adult recipient with familial amyloid polyneuropathy.
A 33-year-old patient with familial amyloid polyneuropathy (FAP) underwent temporary auxiliary partial orthotopic liver transplantation (APOLT) from a living donor with a small-for-size graft. The auxiliary left lobar graft, which weighed only 230 g, was orthotopically transplanted after resection of the recipient's left lobe. The right portal vein was transected to induce compensatory hypertrophy of the left lobar graft. Posttransplant computed tomography showed atrophy of the native liver and hypertrophy of the graft, the volume of which had increased to 446 ml by postoperative day 41. The remnant native liver was removed 6 weeks after APOLT, and there were no signs of liver dysfunction during the postoperative course. Our experience with this case suggests that temporary APOLT is the treatment of choice, guaranteeing a sufficient margin of safety for both donor and recipient, in living donor liver transplants for FAP where the donor's left lobe is disproportionately small.
Ikegami
Toshihiko
T
1st Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan 390-8621.
Kawasaki
Seiji
S
Ohno
Yasunari
Y
Chisuwa
Hisanao
H
Urata
Koichi
K
Nakazawa
Yuichi
Y
Hashikura
Yasuhiko
Y
Terada
Masaru
M
Miyagawa
Shinichi
S
Takei Yi
Yo-ichi
Y
Tokuda
Takahiko
T
Ikeda Si
Shu-ichi
S
D000328:Adult; D028227:Amyloid Neuropathies, Familial / Q000473:pathology / Q000601:surgery*; D005190:Family; D005260:Female; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008099:Liver / Q000033:anatomy & histology; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D020858:Tissue and Organ Harvesting / Q000379:methods