AII (Rod) amacrine cells form a network of electrically coupled interneurons in the mammalian retina.
AII (rod) amacrine cells in the mammalian retina are reciprocally connected via gap junctions, but there is no physiological evidence that demonstrates a proposed function as electrical synapses. In whole-cell recordings from pairs of AII amacrine cells in a slice preparation of the rat retina, bidirectional, nonrectifying electrical coupling was observed in all pairs with overlapping dendritic trees (average conductance approximately 700 pS). Coupling displayed characteristics of a low-pass filter, with no evidence for amplification of spike-evoked electrical postsynaptic potentials by active conductances. Coincidence detection, as well as precise temporal synchronization of subthreshold membrane potential oscillations and TTX-sensitive spiking, was commonly observed. These results indicate a unique mode of operation and integrative capability of the network of AII amacrine cells.
Veruki
Margaret Lin
ML
University of Bergen, Department of Anatomy and Cell Biology, Arstadveien 19, N-5009 Bergen, Norway.
Hartveit
Espen
E
D000200:Action Potentials / Q000502:physiology; D025042:Amacrine Cells / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D017629:Gap Junctions / Q000378:metabolism*; D066298:In Vitro Techniques; D009415:Nerve Net / Q000166:cytology / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D012160:Retina / Q000166:cytology / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D013997:Time Factors