From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase.
This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With 92 references this paper covers the literature up to June 2001 and emphasizes the potential implication of the mammalian glucosamine-6P synthase in type 2 diabetes.
Teplyakov
Alexey
A
Center for Advanced Research in Biotechnology, University of Maryland, Rockville 20850, USA.
Leriche
Caroline
C
Obmolova
Galya
G
Badet
Bernard
B
Badet-Denisot
Marie-Ange
MA
D000641:Ammonia / Q000378:metabolism*; D000818:Animals; D002384:Catalysis; D018360:Crystallography, X-Ray; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology*; D004926:Escherichia coli / Q000201:enzymology; D005658:Fungi / Q000201:enzymology; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000096:biosynthesis*; D005947:Glucose / Q000737:chemistry* / Q000378:metabolism*; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives* / Q000096:biosynthesis*; D005973:Glutamine / Q000737:chemistry / Q000378:metabolism; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D051379:Mice; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D051381:Rats; D013329:Structure-Activity Relationship
D005973:Glutamine; C001293:glucosamine 6-phosphate; D019298:Glucose-6-Phosphate; D000641:Ammonia; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); D005947:Glucose; D005944:Glucosamine; D009584:Nitrogen