title: Indexes of diastolic RV function: load dependence and changes after chronic RV pressure overload in lambs.
abstract: Diastolic function is a major determinant of ventricular performance, especially when loading conditions are altered. We evaluated biventricular diastolic function in lambs and studied possible load dependence of diastolic parameters [minimum first derivative of pressure vs. time (dP/dt(min)) and time constant of isovolumic relaxation (tau)] in normal (n = 5) and chronic right ventricular (RV) pressure-overloaded (n = 5) hearts by using an adjustable band on the pulmonary artery (PAB). Pressure-volume relations were measured during preload reduction to obtain the end-diastolic pressure-volume relationship (EDPVR). In normal lambs, absolute dP/dt(min) and tau were lower in the RV than in the left ventricle whereas the chamber stiffness constant (b) was roughly the same. After PAB, RV tau and dP/dt(min) were significantly higher compared with control. The RV EDPVR indicated impaired diastolic function. During acute pressure reduction, both dP/dt(min) and tau showed a relationship with end-systolic pressure. These relationships could explain the increased dP/dt(min) but not the increased tau-value after banding. Therefore, the increased tau after banding reflects intrinsic myocardial changes. We conclude that after chronic RV pressure overload, RV early relaxation is prolonged and diastolic stiffness is increased, both indicative of impaired diastolic function.
authors.affiliation: Department of Cardiology, The Netherlands.
authors.forename: Boudewijn P J
authors.initials: BP
authors.lastname: Leeuwenburgh
authors.forename: Paul
authors.initials: P
authors.lastname: Steendijk
authors.forename: Willem A
authors.initials: WA
authors.lastname: Helbing
authors.forename: Jan
authors.initials: J
authors.lastname: Baan
mesh_terms: D000375:Aging; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003971:Diastole / Q000502:physiology*; D006321:Heart / Q000254:growth & development / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D012756:Sheep; D014664:Vasodilation / Q000502:physiology; D016278:Ventricular Function, Right / Q000187:drug effects / Q000502:physiology*