Levels of mannose binding lectin in early pregnancy complicated by diabetes mellitus type 1--preliminary report.
The complement system plays an important role as a product of innate and acquired immune reaction. It can be activated via three different routes: the classical pathway, the alternative pathway and the lectin pathway. MBL (mannose-binding lectin) is considered to be a pathogen recognising receptor (PRR), an important factor in recognising pathogen associated molecular pattern (PAMP). The aim of study was to evaluate MBL in early pregnancy of diabetic mothers. Higher values of MBL were observed in diabetic non-pregnant women compared to healthy non-pregnant. Subjects early pregnancy seems to decrease MBL values in both diabetic and healthy pregnant women.
Pertyńska
M
M
Fetal-Maternal Medicine Dept, Research Institute Polish Mother's Memorial Hospital, Łódź.
Tchórzewski
H
H
Cedzyński
M
M
Lewkowicz
P
P
Sobczak
M
M
Cypryk
K
K
Wilczyński
J
J
D000328:Adult; D002352:Carrier Proteins / Q000097:blood* / Q000276:immunology; D037222:Collectins; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000276:immunology*; D005260:Female; D006442:Glycated Hemoglobin / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011254:Pregnancy in Diabetics / Q000097:blood* / Q000276:immunology; D017382:Reactive Oxygen Species / Q000097:blood
D002352:Carrier Proteins; D037222:Collectins; D006442:Glycated Hemoglobin; D017382:Reactive Oxygen Species