Juvenile rheumatoid arthritis with amyloid goiter: report of a case with review of the literature.
Clinically significant enlargement of the thyroid owing to amyloid deposition is a rare occurrence. A 23-yr-old female, a case of juvenile rheumatoid arthritis, developed rapidly increasing thyromegaly during the course of her illness with complaints of dyspnea and dysphagia. Thyroid function tests were within normal limits. Fine-needle aspiration cytology proved inconclusive. Total thyroidectomy was done for symptomatic relief with a preoperative clinical impression of malignancy. Histopathologic findings were consistent with amyloid goiter. The findings of this case are presented, to emphasize the difficulties in making a definite preoperative diagnosis, along with a brief review of the literature.
Srivastava
A
A
Department of Pathology, New England Medical Center, 750 Washington Street, Boston, MA 02111, USA. E-mail: ASrivastava@Lifespan.org
Baxi
M
M
Yadav
S
S
Agarwal
A
A
Gupta
R K
RK
Misra
S K
SK
Mithal
A
A
D000328:Adult; D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D001171:Arthritis, Juvenile / Q000150:complications* / Q000473:pathology; D005260:Female; D006044:Goiter, Nodular / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D014057:Tomography, X-Ray Computed
D000682:Amyloid