title: Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells.
abstract: The gene expression patterns of primordial germ cells (PGCs) and embryonic stem cells were analyzed by a modified serial analysis of gene expression. During the process, we cloned a novel gene, PGC7, which was preferentially expressed in PGCs. Immunohistochemical analysis revealed that PGC7 was specifically expressed in early pre-implantation embryos, PGCs and oocytes. These results suggest that PGC7 might play an important role in the development of PGCs and oocytes.
authors.affiliation: Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka Suita 565-0871, Japan.
authors.forename: Masatake
authors.initials: M
authors.lastname: Sato
authors.forename: Tohru
authors.initials: T
authors.lastname: Kimura
authors.forename: Ken
authors.initials: K
authors.lastname: Kurokawa
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Fujita
authors.forename: Koichiro
authors.initials: K
authors.lastname: Abe
authors.forename: Masaaki
authors.initials: M
authors.lastname: Masuhara
authors.forename: Teruo
authors.initials: T
authors.lastname: Yasunaga
authors.forename: Akihide
authors.initials: A
authors.lastname: Ryo
authors.forename: Mikio
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Toru
authors.initials: T
authors.lastname: Nakano
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001755:Blastocyst / Q000378:metabolism*; D015152:Blotting, Northern; D015153:Blotting, Western; D002868:Chromosomal Proteins, Non-Histone; D018076:DNA, Complementary / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009865:Oocytes / Q000378:metabolism; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D018076:DNA, Complementary; C466105:DPPA3 protein, human; D011506:Proteins