title: Determinants of mortality in patients with severe blunt head injury.
abstract: BACKGROUND
  Head injury is the leading cause of traumatic death in the United States.
  
  
  OBJECTIVE
  A set of clinical parameters available soon after injury can be used to accurately predict outcome in patients with severe blunt head trauma.
  
  
  METHODS
  Validation cohort study.
  
  
  METHODS
  Urban level I trauma center.
  
  
  METHODS
  Data from patients with severe blunt head injury, as defined by inability to follow commands, were prospectively entered into a neurosurgical database and analyzed. The impact on survival of 23 potentially predictive parameters was studied using univariate analysis. Logistic regression models were used to control for confounding factors and to assess interactions between variables, whose significance was determined by univariate analysis. Goodness of fit was calculated with the Hosmer-Lemeshow c statistic. The predictability of the logistic model was evaluated by measuring the area under the receiver operating characteristic curve (AUC).
  
  
  RESULTS
  Logistic regression analysis revealed that 5 risk factors were independently associated with death. These variables included systemic hypotension in the emergency department, midline shift on computed tomographic scan, intracranial hypertension, and absence of pupillary light reflex. A low Glasgow Coma Scale score and advanced age were found to be highly correlated risk factors that, when combined, were independently associated with mortality. The model showed acceptable goodness of fit, and the AUC was 80.5%.
  
  
  CONCLUSIONS
  Systemic hypotension and intracranial hypertension are the only independent risk factors for mortality that can be readily treated during the initial management of patients with severe head injuries. When used together, Glasgow Coma Scale score and age are significant predictors of mortality.
authors.affiliation: Department of Surgery, Baylor College of Medicine, Houston, TX, USA. schreibm@ohsu.edu
authors.forename: Martin A
authors.initials: MA
authors.lastname: Schreiber
authors.forename: Noriaki
authors.initials: N
authors.lastname: Aoki
authors.forename: Bradford G
authors.initials: BG
authors.lastname: Scott
authors.forename: J Robert
authors.initials: JR
authors.lastname: Beck
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015600:Glasgow Coma Scale; D016489:Head Injuries, Closed / Q000150:complications / Q000401:mortality* / Q000503:physiopathology; D006801:Humans; D007022:Hypotension / Q000209:etiology; D015601:Injury Severity Score; D019586:Intracranial Hypertension / Q000209:etiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology