[Pulmonary carcinoma with myoepithelial differentiation, analogous to basal cell adenocarcionma of the salivary glands: description of a case].
We describe a case of pulmonary carcinoma with myoepithelial differentiation, analogous to basal cell adenocarcinoma of salivary glands. The patient, a 60 year-old man, smoker, presented with three peripheral nodules of the left lung. Preoperative staging was negative for metastatic disease and the patient underwent a surgical resection of the nodules. After 22 months, the patient is alive with no evidence of disease. Microscopically, the tumours were composed of atypical cells arranged in lobules, separated by basal membrane-like material. Immunohistochemically, tumour cells were positive for cytokeratin AE1/AE3, cytokeratin 14, vimentin, calponin, S-100 protein and gliofibrillary acid protein (GFAP). Electron microscopy showed features of epithelial and myoid differentiation and confirmed the myoepithelial nature of the tumour. Pulmonary tumours with myoepithelial differentiation are rare, but they have a wide and distinctive morphological spectrum.
Cavazza
A
A
Servizio di Anatomia Patologica, Ospedale S. Maria Nuova, Viale Risorgimento 80, I-42100 Reggio Emilia, Italia. cavazza.alberto@asmn.re.it
Pasquinelli
G
G
Damiani
S
S
Annessi
V
V
De Franco
S
S
Putrino
I
I
Gardini
G
G
D001485:Basement Membrane / Q000648:ultrastructure; D014408:Biomarkers, Tumor / Q000032:analysis; D002135:Calcium-Binding Proteins / Q000032:analysis; D002280:Basal Cell Carcinoma / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D004848:Epithelium / Q000648:ultrastructure; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007633:Keratins / Q000032:analysis; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008297:Male; D008840:Microfilament Proteins; D008854:Microscopy, Electron; D008875:Middle Aged; D009208:Myoepithelioma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D009363:Neoplasm Proteins / Q000032:analysis; D009928:Organ Specificity; D012074:Remission Induction; D009418:S100 Proteins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000473:pathology; D013194:Staining and Labeling; D014746:Vimentin / Q000032:analysis; D000096985:Calponins
D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D005904:Glial Fibrillary Acidic Protein; D007633:Keratins; D008840:Microfilament Proteins; D009363:Neoplasm Proteins; D009418:S100 Proteins; D014746:Vimentin; D000096985:Calponins