title: Evaluation of serum and saliva components in candidosis patients.
abstract: The serum and saliva components of 36 chronic Candidosis patients, both male and female, ages 38-82 who attended the Department of Clinical Stomatology were studied. Total Mucous Lesion Index (TMLI) and salivary flow rate were assessed. The following parameters were evaluated: iron bound protein, unsaturated iron binding capacity, peroxidase activity, protein content, OSCN-, SCN-, IgAs, Candida and St. mutans levels and lactobacilli activity. Candidosis patients exhibited higher Candida CFU values and increased activity of the peroxidase system (p < 0.05) whereas unsaturated iron binding capacity was significantly lower as compared to healthy subjects (p < 0.05). Furthermore, TMLI and Candida CFU values were higher in diseased subjects wearing complete prosthesis as compared to those without complete prosthesis. Diseased subjects with < 1.2 ml/min salivary flow rate exhibited even greater differences with control. This subgroup exhibited a marked reduction in IgAs. The serum components assayed were iron bound protein, unsaturated iron binding capacity, IgG, IgA and IgM. Unsaturated iron binding capacity was significantly lower in the Candidosis group (p = 0.03). Subjects suffering from oral Candidosis display deficiencies in some of their saliva components, evidencing impaired oral defense capacity.
authors.affiliation: Departments of Introduction to Chemistry and Biophysics, Biology Clinical Stomatology, and Biochemistry, Faculty of Dentistry, National University of Córdoba, Córdoba, Argentina.
authors.forename: S T
authors.initials: ST
authors.lastname: Dorronsoro de Cattoni
authors.forename: L S
authors.initials: LS
authors.lastname: Cornejo
authors.forename: S
authors.initials: S
authors.lastname: López de Blanc
authors.forename: S
authors.initials: S
authors.lastname: Calamari
authors.forename: F
authors.initials: F
authors.lastname: Femopase
authors.forename: A I
authors.initials: AI
authors.lastname: Azcurra
authors.forename: L J
authors.initials: LJ
authors.lastname: Battellino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002180:Candidiasis, Oral / Q000097:blood* / Q000378:metabolism* / Q000382:microbiology; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007132:Immunoglobulin Isotypes / Q000097:blood; D007501:Iron / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010544:Peroxidases / Q000378:metabolism; D011485:Protein Binding; D012463:Saliva / Q000737:chemistry; D012471:Salivary Proteins and Peptides / Q000032:analysis
chemical_list: D007071:Immunoglobulin A, Secretory; D007132:Immunoglobulin Isotypes; D012471:Salivary Proteins and Peptides; D007501:Iron; D010544:Peroxidases