title: An extensively hydrolysed cow's milk formula improves clinical symptoms of gastroesophageal reflux and reduces the gastric emptying time in infants.
abstract: BACKGROUND
  About 20 % of infants fed with breast-milk substitutes suffer from Gastro Esophageal Reflux (GER) and 1/3 of them also show Cow's Milk Allergy (CMA) symptoms.
  
  
  METHODS
  We planned this study to assess by dynamic echography the usefulness of an Extensively Hydrolysed Cow's Milk Formula (eHF) in infants suffering from GER. Ten infants showing GER symptoms and 10 normal babies, all fed with breast-milk substitutes, were enrolled. Clinical symptom scores related to GER were assessed for one week. The Gastric Emptying Time (GET) was determined by means of dynamic echography after feeding with cow's milk-derived formulae and again after a week feeding with eHF in subjects previously showing GER symptoms.
  
  
  RESULTS
  All infants with a clinical diagnosis for GER showed an abnormally high average GET in comparison to normal subjects (205 vs 124 min, p = 0.000). Switching to the eHF led to a significant clinical improvement (p = 0.0039) especially in babies skin-test and RAST positive to cow's milk, and to a significant decrease toward the normal value of the GET (167 min, p < 0.001).
  
  
  CONCLUSIONS
  The eHF tested improves GER symptoms in infants suffering from this disease. Our experience confirms and supports the use of dynamic echography as a reliable, simple, and non-invasive diagnostic method for infants with an increased GET associated with clinical symptoms of GER.
authors.affiliation: Pediatric Surgery. Medicine and Surgery Department. Siena University, Siena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Garzi
authors.forename: M
authors.initials: M
authors.lastname: Messina
authors.forename: F
authors.initials: F
authors.lastname: Frati
authors.forename: L
authors.initials: L
authors.lastname: Carfagna
authors.forename: L
authors.initials: L
authors.lastname: Zagordo
authors.forename: M
authors.initials: M
authors.lastname: Belcastro
authors.forename: S
authors.initials: S
authors.lastname: Parmiani
authors.forename: L
authors.initials: L
authors.lastname: Sensi
authors.forename: F
authors.initials: F
authors.lastname: Marcucci
mesh_terms: D000818:Animals; D002417:Cattle; D005260:Female; D005512:Food Hypersensitivity / Q000517:prevention & control; D005746:Gastric Emptying / Q000187:drug effects*; D005764:Gastroesophageal Reflux / Q000000981:diagnostic imaging* / Q000178:diet therapy*; D006801:Humans; D006868:Hydrolysis; D007223:Infant; D007225:Infant Food; D008297:Male; D008892:Milk; D011852:Radioallergosorbent Test; D012882:Skin Tests; D014463:Ultrasonography