Antagonism of activin by inhibin and inhibin receptors: a functional role for betaglycan.
Activin and inhibin research has provided important insight into reproductive physiology as well as many areas involving regulation of cell growth, differentiation and function. Progress in understanding the roles of these hormones in various cell and tissue types has been complimented by novel discoveries at the molecular level that have shed light on ligand/receptor interactions, signaling mechanisms and regulation. While the receptors and signaling pathway for activin are now well characterized, the molecular basis for inhibin action has remained relatively unclear. Here we summarize recent advances in understanding inhibin's mode of action focusing on our recent identification of betaglycan as an inhibin co-receptor capable of mediating inhibin action.
Gray
Peter C
PC
Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA.
Bilezikjian
Louise M
LM
Vale
Wylie
W
D028341:Activins / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology; D000818:Animals; D006801:Humans; D007265:Inhibins / Q000378:metabolism / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism / Q000502:physiology; D018000:Receptors, Peptide / Q000378:metabolism / Q000502:physiology*; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism / Q000502:physiology
D011509:Proteoglycans; D018000:Receptors, Peptide; D018125:Receptors, Transforming Growth Factor beta; D028341:Activins; D007265:Inhibins