Protein domain analysis in the era of complete genomes.
Domains present one of the most useful levels at which to understand protein function, and domain family-based analysis has had a profound impact on the study of individual proteins. Protein domain discovery has been progressing steadily over the past 30 years. What are the realistically achievable goals of sequence-based domain analysis, and how far off are they for the sequences encoded in eukaryotic genomes? Here we address some of the issues involved in better coverage of sequence-based domain annotation, and the integration of these results within the wider context of genomes, structures and function.
Copley
Richard R
RR
EMBL, Meyerhofstrasse 1, Heidelberg, Germany.
Doerks
Tobias
T
Letunic
Ivica
I
Bork
Peer
P
D000595:Amino Acid Sequence; D000818:Animals; D030562:Databases, Protein; D005057:Eukaryotic Cells; D016678:Genome; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D016415:Sequence Alignment
D011506:Proteins