Roles of PI3Ks in leukocyte chemotaxis and phagocytosis.
Through selective disruption of phosphoinositide 3-kinase (PI3K) activity and the use of green fluorescent protein tagged derivatives of domains capable of specifically binding the lipid products of PI3Ks in vivo, it has been shown that this family of signalling enzymes have vital and distinct roles in chemotaxis, phagocytosis and phagosome maturation in leukocytes.
Stephens
Len
L
The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. len.stephens@bbsrc.ac.uk
Ellson
Chris
C
Hawkins
Phillip
P
D000818:Animals; D016764:Cell Polarity / Q000502:physiology; D002630:Chemotactic Factors / Q000494:pharmacology; D002633:Chemotaxis / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D010587:Phagocytosis / Q000502:physiology*; D010588:Phagosomes / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D002630:Chemotactic Factors; D019869:Phosphatidylinositol 3-Kinases; D020741:rho GTP-Binding Proteins