Advances in high-throughput mass spectrometry.
The evolution of high-throughput drug discovery is readily apparent as the pharmaceutical industry continues to stress the rapid progression of new chemical entities and biological agents through drug discovery and development pipelines. Mass spectrometry and high performance liquid chromatography-mass spectrometry have played an instrumental role in the support and advancement of all facets of high-throughput drug discovery. The introduction of new instrumentation has extended the breadth of mass spectrometric-based capabilities from the characterization of high-throughput organic synthesis products to early adsorption, distribution, metabolism and excretion profiling. Additionally, advances in the capacity and throughput of mass spectrometry systems have concurrently led to the introduction of data management tools to address automated data reduction, archival and mining, as well as analytical data integration to chemical and biological databases.
Morand
K L
KL
Procter & Gamble Pharmaceuticals, Healthcare Research Center, 8700 Mason-Montgomery Road, Mason, OH 45040-8006, USA. morand.kl@pg.com
Burt
T M
TM
Regg
B T
BT
Tirey
D A
DA
D002851:Chromatography, High Pressure Liquid; D013058:Mass Spectrometry / Q000295:instrumentation; D010455:Peptides / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011506:Proteins / Q000737:chemistry; D012984:Software
D010455:Peptides; D004364:Pharmaceutical Preparations; D011506:Proteins