[Effect of combined use of sulfate-sodium chloride mineral water and captopril in experimental atherosclerosis].
Course effects of mineral water (MW) Dzhemukhskaya and captopril were studied in 80 Wistar male rats with experimental atherosclerosis. Captopril significantly enhanced effects of MW. Aldosterone levels decreased 2.2 times, triiodothyronine--by 57.2%, atherogenic index--2 fold. ACTH and hydrocortisone concentrations noticeably went up. High glucose levels in the blood diminished. Elevated levels of AlT and AsT normalized. Favourable shifts in combined use of MW and captopril in various doses were nearly the same, in some cases lower dose of captopril was more effective.
Polushina
N D
ND
Naĭdenov
S P
SP
Kozhevnikov
S A
SA
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000450:Aldosterone / Q000097:blood; D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy / Q000628:therapy*; D001786:Blood Glucose / Q000032:analysis; D002216:Captopril / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D006854:Hydrocortisone / Q000097:blood; D008111:Liver Function Tests; D008900:Mineral Waters; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride; D013431:Sulfates; D014284:Triiodothyronine / Q000097:blood
D001786:Blood Glucose; D008900:Mineral Waters; D013431:Sulfates; D014284:Triiodothyronine; D012965:Sodium Chloride; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D002216:Captopril; D006854:Hydrocortisone