title: Human genome project: pharmacogenomics and drug development.
abstract: Now that all 30,000 or so genes that make up the human genome have been deciphered, pharmaceutical industries are emerging to capitalize the custom based drug treatment. Understanding human genetic variation promises to have a great impact on our ability to uncover the cause of individual variation in response to therapeutics. The study of association between genetics and drug response is called pharmacogenomics. The potential implication of genomics and pharmacogenomics in clinical research and clinical medicine is that disease could be treated according to the interindividual differences in drug disposition and effects, thereby enhancing the drug discovery and providing a stronger scientific basis of each patient's genetic constitution. Sequence information derived from the genomes of many individuals is leading to the rapid discovery of single nucleotide polymorphisms or SNPs. Detection of these human polymorphisms will fuel the discipline of pharmacogenomics by developing more personalized drug therapies. A greater understanding of the way in which individuals with a particular genotype respond to a drug allows manufacturers to identify population subgroups that will benefit most from a particular drug. The increasing emphasis on pharmacogenomics is likely to raise ethical and legal questions regarding, among other things, the design of research studies, the construction of clinical trials and the pricing of drugs.
authors.affiliation: Indian Council of Medical Research, New Delhi.
authors.forename: N K
authors.initials: NK
authors.lastname: Ganguly
authors.forename: R
authors.initials: R
authors.lastname: Bano
authors.forename: S D
authors.initials: SD
authors.lastname: Seth
mesh_terms: D015195:Drug Design; D004358:Drug Therapy / Q000639:trends*; D023281:Genomics; D016045:Human Genome Project; D006801:Humans; D010600:Pharmacology