title: Glycopeptide antibiotics and development of inhibitors to overcome vancomycin resistance.
abstract: This review outlines the history of vancomycin and other key glycopeptide antibiotics and the molecular basis of vancomycin resistance, and focuses on the development of synthetic inhibitors of vancomycin-resistant enzymes VanR, S, A, H and X to overcome resistance. The literature up to July 2001 is reviewed and 119 references are cited.
authors.affiliation: Department of Chemistry and Biochemistry, Southern Illinois University at Carbondale, 62901-4409, USA. ygao@chem.siu.edu
authors.forename: Yong
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000378:metabolism; D016983:Enterococcus / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D006020:Glycopeptides; D006094:Gram-Positive Bacteria / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure; D011494:Protein Kinases / Q000378:metabolism; D046929:Serine-Type D-Ala-D-Ala Carboxypeptidase; D013290:Streptococcal Infections / Q000188:drug therapy*; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology; D014157:Transcription Factors / Q000378:metabolism; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D006020:Glycopeptides; C454080:LY266,400; C454081:LY266,408; D013844:Thiazoles; D014157:Transcription Factors; C073902:VanR protein, bacteria; C073901:VanS protein, Enterococcus; D011494:Protein Kinases; D046929:Serine-Type D-Ala-D-Ala Carboxypeptidase; C091956:VanX dipeptidase