title: La Crosse virus: replication in vertebrate and invertebrate hosts.
abstract: La Crosse virus is maintained in a cycle involving mosquitoes and small mammals. Vertebrate cell infection is generally cytolytic; vector cell infection results in persistent infection. Features of La Crosse virus replication that may permit the virus to traffic between vector and vertebrate hosts and condition different infection outcomes are described.
authors.affiliation: USDA, Agricultural Research Service, Animal Disease Research Unit, 3003 ADBF, Washington State University, Pullman, Washington 99164, USA.
authors.forename: Monica K
authors.initials: MK
authors.lastname: Borucki
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Kempf
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Blitvich
authors.forename: Carol D
authors.initials: CD
authors.lastname: Blair
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Beaty
mesh_terms: D000330:Aedes / Q000254:growth & development / Q000821:virology; D000595:Amino Acid Sequence; D000818:Animals; D009033:Culicidae / Q000821:virology*; D018562:Disease Transmission, Infectious; D004670:Encephalitis, California / Q000635:transmission; D006790:Host-Parasite Interactions; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D018062:La Crosse virus / Q000235:genetics* / Q000254:growth & development*; D008322:Mammals / Q000821:virology*; D051379:Mice; D008957:Models, Genetic; D014779:Virus Replication