[Changes in functional activity of the synthetic apparatus of rat thymocytes under acute and chronic gamma-irradiation].
The changes in functional activity of rat thymocyte synthetic apparatus (synthetic activity) under acute (7.5 Gy) and continuous (dose rates 14.4 and 0.43 cGy/day) gamma-irradiation were studied by the fluorescent microspectral analysis. It has been shown that after the acute irradiation the changes in synthetic activity occurred in three main stages. The stages reflect the depression and activation of synthetic processes that is due to interphase and reproductive cell death and urgent recovery of thymus cellularity and secondary repopulating. Under continuous irradiation with a dose rate 14.4 cGy/day in long-term period both the decrease of thymocyte synthetic activity (in most animals) and activation (in the animals with pronounced symptoms of radiation damage) were observed. This reflects the depression processes in immune system and augmentation of immunoreactivity due to mass antigen influence of transformed cells and infectious agents on thymocytes. Under low dose ionizing irradiation (dose rate 0.43 cGy/day) the undulating changes in synthetic processes in thymus cells were observed. This depends on the recurrence of depression and recovery processes in the blood-forming tissue.
Sergievich
L A
LA
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290 Russia. Lyudam@icb.psn.ru
Karnaukhova
N A
NA
D000165:Acridine Orange; D000818:Animals; D002588:Cesium Radioisotopes; D005720:Gamma Rays; D008297:Male; D011829:Radiation Dosage; D051381:Rats; D017208:Rats, Wistar; D013050:Spectrometry, Fluorescence; D013601:T-Lymphocytes / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors
D002588:Cesium Radioisotopes; D000165:Acridine Orange