title: Generalized character process models: estimating the genetic basis of traits that cannot be observed and that change with age or environmental conditions.
abstract: The genetic analysis of characters that change as a function of some independent and continuous variable has received increasing attention in the biological and statistical literature. Previous work in this area has focused on the analysis of normally distributed characters that are directly observed. We propose a framework for the development and specification of models for a quantitative genetic analysis of function-valued characters that are not directly observed, such as genetic variation in age-specific mortality rates or complex threshold characters. We employ a hybrid Markov chain Monte Carlo algorithm involving a Monte Carlo EM algorithm coupled with a Markov chain approximation to the likelihood, which is quite robust and provides accurate estimates of the parameters in our models. The methods are investigated using simulated data and are applied to a large data set measuring mortality rates in the fruit fly, Drosophila melanogaster.
authors.affiliation: Department of Biology, University College London, UK. s.pletcher@ucl.ac.uk
authors.forename: Scott D
authors.initials: SD
authors.lastname: Pletcher
authors.forename: Florence
authors.initials: F
authors.lastname: Jaffrézic
mesh_terms: D000367:Age Factors; D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development; D016013:Likelihood Functions; D008297:Male; D008957:Models, Genetic; D019655:Quantitative Trait, Heritable