title: Isoflavones, substances with multi-biological and clinical properties.
abstract: Isoflavones, rich in soybean, are currently receiving much attention because of their potential role in preventing and treating cancer and other human chronic diseases. The present review provides an overview of the recent results in this research field. Data from epidemiological reports and laboratories have shown that isoflavones have multi-biological and pharmacological effects in animals and humans. These include estrogenic and antiestrogenic effects, cell signalling conduction, as well as cell growth and death. Based on these properties, soy protein and isoflavones have been associated with reduced incidences of breast and prostate cancers, cardiovascular diseases or osteoporosis, and exhibit some other favorable effects. The mechanism through which isoflavones may exert the above-mentioned functions are not only based on the estrogenic properties of isoflavones, but also on their role as protein tyrosine kinase inhibitors, as regulators of gene transcription, modulators of transcription factors, antioxidants, as well as by altering some enzyme activities. However, to draw a clear conclusion regarding the clinical use of isoflavones further investigation would be required, although only a few effects of short- or long-term use of soy proteins are known in humans.
authors.affiliation: Department of Muscle Biology and Growth, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany.
authors.forename: M Q
authors.initials: MQ
authors.lastname: Ren
authors.forename: G
authors.initials: G
authors.lastname: Kuhn
authors.forename: J
authors.initials: J
authors.lastname: Wegner
authors.forename: J
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D004032:Diet; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007529:Isoflavones / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D009369:Neoplasms / Q000517:prevention & control*; D010024:Osteoporosis / Q000517:prevention & control*; D015398:Signal Transduction / Q000187:drug effects; D030262:Soybean Proteins / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D007529:Isoflavones; D030262:Soybean Proteins; D002784:Cholesterol