Chromosome translocations: dangerous liaisons revisited.
Although it has been clear for more than a century that the chromosomes in human tumour cells are often wildly abnormal, there has been controversy as to whether these changes are primary events or are merely secondary epiphenomena that reflect the genomic instability of these cells. The prevailing view for most of this period was that chromosome changes were secondary events. What happened to change this view?
Rowley
J D
JD
Department of Medicine, University of Chicago Medical Center, Illinois 60637, USA. jrowley@medicine.bsd.uchicago.edu
D002471:Cell Transformation, Neoplastic / Q000235:genetics; D003582:Cytogenetics / Q000266:history; D005544:Forecasting; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000266:history; D009369:Neoplasms / Q000235:genetics*; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic