Bullous lesions in Bazex syndrome and successful treatment with oral psoralen phototherapy.
A 59-year-old man presented with a psoriasiform dermatitis with associated bullae and destructive nail dystrophy of the hands and feet. He had lost 10 kg weight over 6 months and a mass in the neck was noted. He was provisionally diagnosed with Bazex syndrome (acrokeratosis paraneoplastica) and subsequent investigations revealed a squamous cell carcinoma in the right piriform fossa. His skin lesions were treated with oral psoralen and ultraviolet A phototherapy and this cleared the cutaneous changes, but the nail changes have persisted at 18 months follow up.
Gill
D
D
Department of Dermatology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Fergin
P
P
Kelly
J
J
D000169:Acrodermatitis / Q000473:pathology / Q000628:therapy; D000284:Administration, Oral; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology / Q000628:therapy*; D005363:Ficusin / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007642:Keratosis / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy / Q000379:methods*; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000473:pathology / Q000628:therapy*; D017319:Photosensitizing Agents / Q000627:therapeutic use*
D017319:Photosensitizing Agents; D005363:Ficusin