title: A tripeptide discriminator for stop codon recognition.
abstract: Only recently has it been established that a tripeptide in the bacterial release factors (RFs), RF1 and RF2, is responsible for the stop codon recognition. This functional mimic of the anticodon of tRNA is referred to as a tripeptide 'anticodon' or a tripeptide discriminator. Here we review the experimental background and process leading to this discovery, and strengthen functional evidence for the tripeptide determinant for deciphering stop codons in mRNAs in prokaryotes.
authors.affiliation: Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8630, Tokyo, Japan. nak@ims.u-tokyo.ac.jp
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
mesh_terms: D018388:Codon, Terminator / Q000737:chemistry / Q000378:metabolism*; D010454:Peptide Termination Factors / Q000737:chemistry / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011387:Prokaryotic Cells; D014176:Protein Biosynthesis / Q000502:physiology*; D012333:RNA, Messenger / Q000502:physiology
chemical_list: D018388:Codon, Terminator; D010454:Peptide Termination Factors; D010455:Peptides; D012333:RNA, Messenger