Mutagenic profiles of carbazole in the male germ cells of Swiss albino mice.
Mutagenic effect of carbazole was evaluated by employing dominant lethal mutation and sperm head abnormality assays in male Swiss albino mice. For the dominant lethal mutation assay, adult male mice were treated for five consecutive days either with 30 or 60 mg/kg body weight (b.w.) of carbazole by single intraperitoneal (i.p.) injection. For the sperm head abnormality assay mice were treated with 50, 100, 150, 200 and 300 mg/kg b.w as a single i.p. injection. Treatment of adult male mice with carbazole resulted in induction of dominant lethal mutation and abnormal sperm heads. The results show that carbazole is mutagenic in male germ cells of mice.
Jha
Anand M
AM
Department of Botany and Biotechnology, Genetic Toxicology Laboratory, Samastipur College, Samastipur, Bihar 848 134, India. jhaanandmohan@yahoo.co.uk
Bharti
Mithilesh K
MK
D000818:Animals; D002227:Carbazoles / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D013077:Sperm Head / Q000187:drug effects; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects*
D002227:Carbazoles; D002273:Carcinogens; D009153:Mutagens; C041514:carbazole