Angiotensin II-mediated signal transduction pathways.
The renin-angiotensin system is one of the major cardiovascular systems that controls blood volume, peripheral vascular tone, and blood pressure. Recent studies indicate important roles for angiotensin II in inflammation, atherosclerosis, and congestive heart failure as well. It is gradually becoming clear that angiotensin II exerts effects on the cardiovascular system through several unique mechanisms, including the availability of two different angiotensin II receptors, recruitment of protein tyrosine kinase activity, and receptor tyrosine kinase transactivation. This review discusses the diverse mechanisms of angiotensin II-mediated signal transduction pathways and the various effects of angiotensin II on the cardiovascular system.
Saito
Yuji
Y
Center for Cardiovascular Research, University of Rochester, 601 Elmwood Avenue, Box 679, Rochester, NY 14642, USA.
Berk
Bradford C
BC
D000804:Angiotensin II / Q000494:pharmacology / Q000502:physiology*; D002319:Cardiovascular System / Q000187:drug effects; D006801:Humans; D020794:Receptor Protein-Tyrosine Kinases / Q000187:drug effects / Q000378:metabolism; D011945:Receptors, Angiotensin / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D013939:Thymidine Phosphorylase / Q000187:drug effects / Q000378:metabolism; D015533:Transcriptional Activation / Q000187:drug effects / Q000502:physiology
D011945:Receptors, Angiotensin; D000804:Angiotensin II; D013939:Thymidine Phosphorylase; D020794:Receptor Protein-Tyrosine Kinases