Molecular, structural, and cellular biology of follitropin and follitropin receptor.
Follitropin and the follitropin receptor are essential for normal gamete development in males and females. This review discusses the molecular genetics and structural and cellular biology of the follitropin/follitropin receptor system. Emphasis is placed on the human molecules when possible. The structure and regulation of the genes for the follitropin beta subunit and the follitropin receptor is discussed. Control of systemic and cellular protein levels is explained. The structural biology of each protein is described, including protein structure, motifs, and activity relationships. Finally, the follitropin/follitropin receptor signal transduction system is discussed.
Dias
James A
JA
Wadsworth Center, David Axelrod Institute for Public Health, New York State Department of Health, Albany, New York 12208, USA.
Cohen
Brian D
BD
Lindau-Shepard
Barbara
B
Nechamen
Cheryl A
CA
Peterson
Andrew J
AJ
Schmidt
Anja
A
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D005640:Follicle Stimulating Hormone / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary / Q000235:genetics / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology; D011962:Receptors, FSH / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D013329:Structure-Activity Relationship
D011962:Receptors, FSH; D005640:Follicle Stimulating Hormone