title: [Monitoring of renal function in epileptic children and teenagers treated with valproic acid or carbamazepine in concomitant therapy with tiagabine].
abstract: The aim of the study was the evaluation of the influence of 4-month concomitant tiagabine (TGB) and valproic acid (VPA) or carbamazepine (CBZ) therapy on renal function of epileptic children and teenagers. Initial parameter values, indicated on renal disfunction, were compared with these obtained after VPA and TGB or CBZ and TGB therapy and with values in healthy children and teenagers. Investigation group was composed of 22 children and teenagers with drug-resistant focal epilepsy. We observed that in the time of concomitant VPA and TGB therapy increased the NAG/g creatinine activity index. In spite the fact of statistical significance of these changes, they were not outside the normal range. beta 2-microglobulin concentrations in urine of epileptic children treated with VPA in monotherapy before concomitant therapy with TGB were higher than in control group. That difference was statistically significant. Addition of TGB to the therapy normalized this parameter. During concomitant VPA and TGB or CBZ and TGB therapy we didn't observe statistically significant changes of parameters indicating on glomerular disfunction. In the VPA therapy before concomitant treatment with tiagabine the disfunction of tubules and glomerules was observed. On the other side in the concomitant VPA and TGB therapy the disfunction of tubules and glomerules didn't occurred. We can conclude that concomitant therapy VPA or CBZ with tiagabine don't affect the renal function in clinical significant manner. Therapy with VPA could leads to minimal disfunction of tubules what is represented by increasing of beta 2-microglobulin level in urine.
authors.affiliation: Katedra i Zakład Farmakologii Klinicznej Akademii Medycznej we Wrocławiu.
authors.forename: M
authors.initials: M
authors.lastname: Hurkacz
authors.forename: A
authors.initials: A
authors.lastname: Wiela-Hojeńska
authors.forename: K
authors.initials: K
authors.lastname: Orzechowska-Juzwenko
authors.forename: A
authors.initials: A
authors.lastname: Kozik
authors.forename: J
authors.initials: J
authors.lastname: Unolt
mesh_terms: D000118:Acetylglucosaminidase / Q000187:drug effects / Q000652:urine; D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D016022:Case-Control Studies; D002648:Child; D018849:Controlled Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000187:drug effects; D007684:Kidney Tubules / Q000187:drug effects; D008297:Male; D009557:Nipecotic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000652:urine; D018709:Statistics, Nonparametric; D000078308:Tiagabine; D013997:Time Factors; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D001613:beta 2-Microglobulin / Q000187:drug effects / Q000652:urine
chemical_list: D000927:Anticonvulsants; D009557:Nipecotic Acids; D001613:beta 2-Microglobulin; D002220:Carbamazepine; D014635:Valproic Acid; D000118:Acetylglucosaminidase; D000078308:Tiagabine