title: Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway.
abstract: When pre-mRNAs are spliced, a multi-component complex is deposited onto them, close to the sites of intron removal. New findings suggest that these exon-exon junction complexes and the complexes that bind mRNA caps are key effectors of the fate of spliced mRNAs and may regulate whether mRNAs containing premature stop codons are degraded.
authors.affiliation: EMBL Heidelberg, Gene Expression Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany. hentze@embl-heidelberg.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Schell
authors.forename: Andreas E
authors.initials: AE
authors.lastname: Kulozik
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Hentze
mesh_terms: D000818:Animals; D018389:Codon, Nonsense / Q000235:genetics*; D005091:Exons / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D014176:Protein Biosynthesis / Q000235:genetics*; D011786:Quality Control; D039381:RNA Cap-Binding Proteins; D012326:RNA Splicing / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000502:physiology
chemical_list: D018389:Codon, Nonsense; D039381:RNA Cap-Binding Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins