title: Magnesium infusion reduces perioperative pain.
abstract: OBJECTIVE
  Magnesium has antinociceptive effects in animal and human models of pain. These effects are primarily based on the regulation of calcium influx into the cell. The aim of this study was to determine whether perioperative infusion of magnesium would reduce postoperative pain and anxiety.
  
  
  METHODS
  Twenty-four patients, undergoing elective hysterectomy, received a bolus of 30 mg kg(-1) magnesium sulphate or the same volume of isotonic sodium chloride solution intravenously before the start of surgery and 0.5 g h(-1) infusion for the next 20 h. Intraoperative and postoperative analgesia were achieved with fentanyl and morphine respectively. Patients were evaluated pre- and postoperatively for anxiety.
  
  
  RESULTS
  Fentanyl consumption and total morphine requirements were significantly decreased in the magnesium group compared to the control group. Postoperative anxiety scores and sedation were similar between groups.
  
  
  CONCLUSIONS
  Continuous magnesium infusion, including the pre-, intra-, and postoperative periods reduces analgesic requirements. These results demonstrate that magnesium can be an adjuvant for perioperative analgesic management.
authors.affiliation: Akdeniz University Medical Faculty, Department of Anaesthesiology and Reanimation, Turkey. kara_hanife@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Kara
authors.forename: N
authors.initials: N
authors.lastname: Sahin
authors.forename: V
authors.initials: V
authors.lastname: Ulusan
authors.forename: T
authors.initials: T
authors.lastname: Aydogdu
mesh_terms: D000328:Adult; D000368:Aged; D016058:Analgesia, Patient-Controlled; D000700:Analgesics / Q000008:administration & dosage* / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007044:Hysterectomy; D007262:Infusions, Intravenous; D008278:Magnesium Sulfate / Q000008:administration & dosage* / Q000627:therapeutic use*; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy* / Q000503:physiopathology; D019990:Perioperative Care; D011446:Prospective Studies
chemical_list: D000700:Analgesics; D008278:Magnesium Sulfate