The effects of magnesium sulphate and EDTA in the hypercholesterolaemic rabbit.
Numerous clinical reports suggest the beneficial effects of chelation therapy for the treatment of atherosclerosis. However, the results of these studies are inconclusive and controversial. The purpose of this present study was to examine the prophylactic and therapeutic effects of chelation liquid (CHL) in experimental atherosclerosis. Twenty New Zealand white rabbits were fed a 1% cholesterol-supplemented diet for 45 days. In the prophylactic phase of the study subcutaneous 300 mg EDTA + 500 mg magnesium sulphate (MgSO4) injections (five rabbits) and isotonic saline (five rabbits) were given to test and control groups, respectively, along with cholesterol rich diet. The CHL treatment ameliorated the rise of serum cholesterol and serum triglyceride concentrations, lowered serum calcium concentrations and reduced the aortic atheroma. In the therapeutic phase of the experiment the cholesterol diet was stopped and the remaining 10 animals were returned to normal diet. Five of these rabbits were given CHL injections and other five animals were given isotonic saline injections for 121 days. Although the level of cholesterol and triglyceride were not significantly different in the two groups, the serum calcium concentration and the percentage of the area of flate aortic specimen occupied by atheroma were significantly lower in the CHL treated rabbits as compared to controls. It is concluded that CHL injections have a definite prophylactic effect on atherogenesis in the cholesterol-fed rabbit, and may have some therapeutic value in the regression phase. Further confirmatory studies are suggested.
Evans
D A
DA
Riyadh Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia Manfouha Central Hospital Riyadh, Kingdom of Saudi Arabia.
Tariq
M
M
Sujata
B
B
McCann
G
G
Sobki
S
S
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood* / Q000473:pathology; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000097:blood; D002614:Chelating Agents / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000494:pharmacology; D004036:Diet, Atherogenic; D004492:Edetic Acid / Q000494:pharmacology*; D006937:Hypercholesterolemia / Q000097:blood*; D008278:Magnesium Sulfate / Q000494:pharmacology*; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D002614:Chelating Agents; D002791:Cholesterol, Dietary; D014280:Triglycerides; D008278:Magnesium Sulfate; D002784:Cholesterol; D004492:Edetic Acid; D002118:Calcium