Dynamics of LDL oxidation in ischemic stroke patients.
OBJECTIVE
Oxidative modification of human low density lipoprotein (LDL) plays an important role in the development of atherosclerosis. The aim of this study was to evaluate the oxidative modification of LDL in the group of patients with ischemic stroke.


METHODS
In the group of 43 patients 3 months after ischemic stroke and in the age and sex-matched control group, the kinetics of LDL oxidation and level of vitamin E were estimated. The susceptibility of LDL to oxidation was evaluated in isolated LDL exposed to in vitro oxidation. In 26 patients, after diet change, clinical and laboratory investigations were repeated 9 months later.


RESULTS
In the patient group, susceptibility of LDL to oxidation was enhanced, lag phase was significantly shorter in comparison with the control group. After a change in diet, significant elongation of the lag phase was observed.


CONCLUSIONS
Diet change improves LDL resistance to oxidation and may influence prognosis in stroke patients.
Ryglewicz
D
D
1st Neurological Department, Institute of Psychiatry and Neurology, Warsaw, Poland. ryglew@ipin.edu.pl
Rodo
M
M
Roszczynko
M
M
Barańska-Gieruszczak
M
M
Szirkowiec
W
W
Swiderska
M
M
Wehr
H
H
D000368:Aged; D001161:Arteriosclerosis / Q000503:physiopathology*; D002545:Brain Ischemia / Q000150:complications* / Q000503:physiopathology; D004032:Diet; D005260:Female; D006801:Humans; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D011379:Prognosis; D020521:Stroke / Q000150:complications* / Q000503:physiopathology; D014810:Vitamin E / Q000032:analysis
D008077:Lipoproteins, LDL; D014810:Vitamin E