Inheritable forms of medullary thyroid carcinoma.
Medullary thyroid carcinoma (MTC) arises from parafollicular or C cells of the thyroid that produce calcitonin. It accounts for 5-10% of all thyroid cancers. Hereditary MTC represents 20-30% of all MTCs. It can be transmitted with an autosomal dominant pattern, either as a single entity, familial MTC, or it can arise as part of a multiple endocrine neoplasia (MEN) syndrome type 2A or 2B. The identification of hereditary MTC has been facilitated in recent years by the direct analysis of the ret proto-oncogene.
Bachelot
Anne
A
Department of Nuclear Medicine and Endocrine Tumors, Institut Gustave-Roussy, Villejuif, France.
Lombardo
Francesca
F
Baudin
Eric
E
Bidart
Jean-Michel
JM
Schlumberger
Martin
M
D000818:Animals; D018276:Carcinoma, Medullary / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D000090063:Proto-Oncogene Mas; D013577:Syndrome; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology