title: Bromodomain: an acetyl-lysine binding domain.
abstract: Bromodomains, an extensive family of evolutionarily conserved protein modules originally found in proteins associated with chromatin and in nearly all nuclear histone acetyltransferases, have been recently discovered to function as acetyl-lysine binding domains. More recent structural studies of bromodomain/peptide ligand complexes have enriched our understanding of differences in ligand selectivity of bromodomains. These new findings demonstrate that bromodomain/acetyl-lysine recognition can serve as a pivotal mechanism for regulating protein-protein interactions in numerous cellular processes including chromatin remodeling and transcriptional activation, and reinforce the concept that functional diversity of a conserved protein modular structure is achieved by evolutionary changes of amino acid sequences in the ligand binding site.
authors.affiliation: Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, 1425 Madison Avenue, P.O. Box 1677, New York, NY 10029-6574, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Zeng
authors.forename: Ming Ming
authors.initials: MM
authors.lastname: Zhou
mesh_terms: D000107:Acetylation; D000123:Acetyltransferases / Q000737:chemistry* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002843:Chromatin / Q000737:chemistry* / Q000378:metabolism; D017124:Conserved Sequence; D019143:Evolution, Molecular; D015696:Gene Products, tat / Q000737:chemistry / Q000378:metabolism; D015497:HIV-1; D051548:Histone Acetyltransferases; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000378:metabolism; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D029701:Saccharomyces cerevisiae Proteins; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism; D054322:tat Gene Products, Human Immunodeficiency Virus; D000092468:Bromodomain Containing Proteins
chemical_list: D000123:Acetyltransferases; D002843:Chromatin; D015696:Gene Products, tat; D051548:Histone Acetyltransferases; D008239:Lysine; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D054322:tat Gene Products, Human Immunodeficiency Virus; C091342:BDF1 protein, S cerevisiae; D000092468:Bromodomain Containing Proteins