title: Effect of hydroxyurea therapy on resting energy expenditure in children with sickle cell disease.
abstract: Effects of hydroxyurea therapy on resting energy expenditure (REE) in children with sickle cell disease have not been evaluated. Eight children with sickle cell disease were examined before hydroxyurea therapy and again 6.9 +/- 3.5 months after hydroxyurea initiation. Resting energy expenditure, dietary intake, and growth were assessed. In six children, baseline REE was elevated, and REE decreased an average of 17% with hydroxyurea. This was associated with a significant increase in fetal hemoglobin. These pilot data suggest that hydroxyurea may curtail the hypermetabolic state observed in children with sickle cell disease and may offer a clinically important secondary benefit.
authors.affiliation: The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, 19104, USA.
authors.forename: E B
authors.initials: EB
authors.lastname: Fung
authors.forename: E M
authors.initials: EM
authors.lastname: Barden
authors.forename: D A
authors.initials: DA
authors.lastname: Kawchak
authors.forename: B S
authors.initials: BS
authors.lastname: Zemel
authors.forename: K
authors.initials: K
authors.lastname: Ohene-Frempong
authors.forename: V A
authors.initials: VA
authors.lastname: Stallings
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D000986:Antisickling Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001481:Basal Metabolism / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D002149:Energy Intake / Q000187:drug effects; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology* / Q000627:therapeutic use; D007223:Infant; D008297:Male; D009748:Nutrition Disorders / Q000209:etiology / Q000517:prevention & control; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D000986:Antisickling Agents; D005319:Fetal Hemoglobin; D006918:Hydroxyurea