Synthesis, conformational analysis, and bioassay of 9,10-didehydroepothilone D.
[reaction: see text] 9,10-Didehydroepothilone D was synthesized, its conformation was studied, and its tubulin polymerization and antiproliferative activity were compared with that of epothilone D and certain analogues.
White
James D
JD
Department of Chemistry, Oregon State University, Corvallis 97331-4003, USA. james.white@orst.edu
Sundermann
Kurt F
KF
Wartmann
Markus
M
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001704:Biopolymers; D002455:Cell Division / Q000187:drug effects; D034261:Epothilones; D008968:Molecular Conformation; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014404:Tubulin / Q000737:chemistry / Q000187:drug effects
C442200:9,10-dehydroepothilone D; D000970:Antineoplastic Agents; D001704:Biopolymers; D034261:Epothilones; D013844:Thiazoles; D014404:Tubulin