title: Structural approach of the mechanism of inhibition of alpha-chymotrypsin by coumarins.
abstract: A pharmacophore associated to the inhibiton of alpha-chymotrypsin has been built based on the structural and electronic characterization of a series of coumarin derivatives.
authors.affiliation: Laboratoire de Chimie Moléculaire Structurale, Facultés Universitaires N.-D. de la Paix, 61 rue de Bruxelles, B-5000 Namur, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Wouters
authors.forename: Marjorie
authors.initials: M
authors.lastname: Huygens
authors.forename: Lionel
authors.initials: L
authors.lastname: Pochet
authors.forename: Bernard
authors.initials: B
authors.lastname: Pirotte
authors.forename: François
authors.initials: F
authors.lastname: Durant
authors.forename: Bernard
authors.initials: B
authors.lastname: Masereel
mesh_terms: D000925:Anticoagulants / Q000494:pharmacology*; D001665:Binding Sites; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D003374:Coumarins / Q000494:pharmacology*; D003460:Crystallization; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008961:Models, Structural
chemical_list: D000925:Anticoagulants; D003374:Coumarins; D002918:Chymotrypsin; C117608:alpha-chymotrypsin