Lessons from HIV: movement of macromolecules inside the cell.
Molecular biological investigations of HIV have made fundamental contributions to our understanding of eukaryotic biology. These studies elucidated new paradigms in transcription, RNA and protein export from the nucleus to the cytoplasm, cellular activation, morphology and vesicular trafficking.
Fackler
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Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, USA.
Peterlin
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BM
Weis
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D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology; D015694:Gene Products, rev / Q000378:metabolism; D015696:Gene Products, tat / Q000378:metabolism; D006678:HIV / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D012191:Retroviridae Proteins / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology; D054321:rev Gene Products, Human Immunodeficiency Virus; D054322:tat Gene Products, Human Immunodeficiency Virus
D015694:Gene Products, rev; D015696:Gene Products, tat; D012191:Retroviridae Proteins; D054321:rev Gene Products, Human Immunodeficiency Virus; D054322:tat Gene Products, Human Immunodeficiency Virus