title: MR cholangiography in the evaluation of hepatic and biliary abnormalities in autosomal dominant polycystic kidney disease: study of 93 patients.
abstract: OBJECTIVE
  The purpose of this work was to conduct an MR cholangiography study of hepatobiliary abnormalities in autosomal dominant polycystic kidney disease (ADPKD) and to correlate these abnormalities with the risk of infection.
  
  
  METHODS
  Cystic and intrahepatic bile duct (IHBD) abnormalities identified by MR cholangiography in 93 ADPKD patients were studied retrospectively. A blind study of liver function tests, renal insufficiency, and infectious episodes was also carried out. Correlations among these data were looked for using univariate analysis.
  
  
  RESULTS
  Intrahepatic cysts were present in 84 of 93 patients and peribiliary cysts in 59 of 90 patients. IHBDs were abnormal in 25 of 90 patients (tubular dilatation in 15 cases and bead-like dilatation in 16). IHBD abnormalities were correlated with hepatobiliary infections (p = 0.0012), gamma-glutamyltranspeptidase elevation (p = 0.018), and terminal renal failure (p = 0.006).
  
  
  CONCLUSIONS
  This study confirms the complexity of hepatobiliary involvement in ADPKD. Various types of cystic lesions can arise, and patients with IHBD abnormalities are at increased risk for hepatobiliary infection.
authors.affiliation: Radiology Imaging Department, University Hospital Le Bocage, Dijon, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Dranssart
authors.forename: Francois
authors.initials: F
authors.lastname: Cognet
authors.forename: Christiane
authors.initials: C
authors.lastname: Mousson
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Cercueil
authors.forename: Gerard
authors.initials: G
authors.lastname: Rifle
authors.forename: Denis
authors.initials: D
authors.lastname: Krause
mesh_terms: D000328:Adult; D000368:Aged; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D002758:Cholangiography / Q000379:methods*; D003560:Cysts / Q000473:pathology; D005260:Female; D006801:Humans; D007239:Infections / Q000209:etiology; D007674:Kidney Diseases / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors