Putting tumours in context.
The interactions between cancer cells and their micro- and macroenvironment create a context that promotes tumour growth and protects it from immune attack. The functional association of cancer cells with their surrounding tissues forms a new 'organ' that changes as malignancy progresses. Investigation of this process might provide new insights into the mechanisms of tumorigenesis and could also lead to new therapeutic targets.
Bissell
M J
MJ
Division of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California 99720, USA. mjbissell@lbl.gov
Radisky
D
D
D000818:Animals; D006801:Humans; D020782:Matrix Metalloproteinases / Q000502:physiology; D009369:Neoplasms / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D017154:Stromal Cells / Q000502:physiology; D014945:Wound Healing
D020782:Matrix Metalloproteinases