title: Lidocaine-dependent early infantile status epilepticus with highly suppressed EEG.
abstract: We report an early infantile patient characterized by intractable hyponatremia, progressive megalencephaly, and epileptic seizures with an EEG pattern that alternated between interictal low-voltage background and ictal burst activity. Repeatedly all the abnormal findings improved in a lidocaine-dependent manner. Given the pharmacologic mechanisms of lidocaine as a sodium channel blocker, we speculate that our patient had a sodium channel dysfunction.
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Japan. sawaishi@ped.med.akita-u.ac.jp
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sawaishi
authors.forename: Tamami
authors.initials: T
authors.lastname: Yano
authors.forename: Masamichi
authors.initials: M
authors.lastname: Enoki
authors.forename: Goro
authors.initials: G
authors.lastname: Takada
mesh_terms: D004569:Electroencephalography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D026941:Sodium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D013226:Status Epilepticus / Q000188:drug therapy* / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D026941:Sodium Channel Blockers; D008012:Lidocaine