title: Molecular design based on 3D-pharmacophore. Application to 5-HT subtypes receptors.
abstract: A first definition of a pharmacophore for the serotonin reuptake inhibitors was carried out by considering a three-dimensional model which correlates the chemical structures of series of reuptake inhibitors with their biological affinities. A molecular design was described by analyzing two different 3D serotonin pharmacophores. This successful approach enabled us to consider the design of new serotonin ligands by the same method.
authors.affiliation: Centre d'Etudes et de Recherche sur le Médicament de Normandie, Université de Caen, 1, rue Vaubénard, 14032 Caen, France.
authors.forename: Ronan
authors.initials: R
authors.lastname: Bureau
authors.forename: Cyril
authors.initials: C
authors.lastname: Daveu
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Lancelot
authors.forename: Sylvain
authors.initials: S
authors.lastname: Rault
mesh_terms: D015195:Drug Design; D011985:Receptors, Serotonin / Q000145:classification*; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry*
chemical_list: D011985:Receptors, Serotonin; D017367:Selective Serotonin Reuptake Inhibitors