The basal ganglia and disorders of movement: pathophysiological mechanisms.
The basal ganglia are part of a neuronal network organized in parallel circuits. The "motor circuit" is most relevant to the pathophysiology of movement. Abnormal increment or reduction in the inhibitory output activity of basal ganglia give rise, respectively, to poverty and slowness of movement (i.e., Parkinson's disease) or dyskinesias.
Obeso
José A
JA
Department of Neurology, Clinica Universitaria and Medical School, University of Navarra, Pamplona 31008, Spain.
Rodríguez-Oroz
María C
MC
Rodríguez
Manuel
M
Arbizu
Javier
J
Giménez-Amaya
José M
JM
D001479:Basal Ganglia / Q000166:cytology / Q000503:physiopathology*; D006801:Humans; D009069:Movement Disorders / Q000503:physiopathology*; D009434:Neural Pathways