title: Non-convulsive status epilepticus induced by tiagabine in a patient with pseudoseizure.
abstract: Tiagabine, a novel GABA reuptake inhibitor, has been reported to induce non-convulsive status epilepticus (NCSE) in patients with epilepsy. We report a 27 year old female with history of pseudoseizure documented by video-EEG monitoring who presented confusion while on 56 mg per day of tiagabine. Electroencephalography showed generalized sharp and slow wave discharges, consistent with NCSE. The NCSE was terminated by lorazepam and did not recur after tiagabine was discontinued. This case report suggests that tiagabine may induce NCSE in patients without epilepsy.
authors.affiliation: Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.forename: Bradley V
authors.initials: BV
authors.lastname: Vaughn
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D009557:Nipecotic Acids / Q000008:administration & dosage / Q000009:adverse effects*; D012640:Seizures / Q000175:diagnosis / Q000188:drug therapy*; D013226:Status Epilepticus / Q000139:chemically induced* / Q000175:diagnosis; D000078308:Tiagabine; D014741:Video Recording
chemical_list: D000927:Anticonvulsants; D009557:Nipecotic Acids; D000078308:Tiagabine