The entorhinal cortex-nucleus accumbens pathway and latent inhibition: a behavioral and neurochemical study in rats.
Latent inhibition (LI) refers to the decrease in conditioned response produced by the repeated nonrein-forced preexposure to the to-be-conditioned stimulus. Experiment I investigated the effects of electrolytic lesions of the entorhinal cortex on LI in a conditioned emotional response procedure. Entorhinal cortex lesions attenuated LI. Experiments 2 and 3 investigated whether this attenuation of LI could result from a modification in nucleus accumbens (NAcc) dopamine (DA) release. Rats with entorhinal cortex lesions displayed normal spontaneous and amphetamine-induced locomotor activity, as well as normal basal and amphetamine-induced release of DA within the NAcc (assessed by microdialysis). Taken together, these results show that entorhinal cortex lesions disrupt LI in a way that is unlikely to be due to an alteration of DA release within the NAcc.
Coutureau
Etienne
E
Laboratoire de Neurosciences Comportementales et Cognitives, Centre National de la Recherche Scientifique, Université Louis Pasteur, Strasbourg, France. coutureaue@cardiff.ac.uk
Léna
Isabelle
I
Daugé
Valérie
V
Di Scala
Georges
G
D000818:Animals; D001143:Arousal / Q000502:physiology; D003214:Conditioning, Classical / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D018728:Entorhinal Cortex / Q000502:physiology*; D005239:Fear / Q000502:physiology; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009714:Nucleus Accumbens / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans
D004298:Dopamine