HIV-1 and the brain: connections between HIV-1-associated dementia, neuropathology and neuroimmunology.
AIDS patients frequently exhibit neurological disorders due to the neurotoxic events that result from HIV-1 and/or opportunistic infections in the brain. This review examines recent clinical findings related to HIV-1-associated dementia, and outlines current areas of basic research that may clarify how HIV-1-associated encephalopathy produces clinical symptoms of brain dysfunction.
Lawrence
Diane M
DM
Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 5W21, 36 Convent Drive, MSC 4164, Bethesda, MD 20892-4164, USA. lawrencd@ninds.nih.gov
Major
Eugene O
EO
D015526:AIDS Dementia Complex / Q000276:immunology* / Q000473:pathology*; D001921:Brain / Q000276:immunology / Q000473:pathology; D018792:Encephalitis, Viral / Q000276:immunology; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D018448:Models, Immunological