Localized melanosis in an immunocompromised patient with local metastatic melanoma.
BACKGROUND
Melanosis is a rare, but well recognized late complication of some cases of metastatic melanoma. The precise pathogenesis is unclear. Most described cases report diffuse metastases and diffuse melanosis.


OBJECTIVE
To present a case of localized melanosis secondary to locally metastatic melanoma without evidence of systemic involvement in a renal transplant patient.


METHODS
Case report and literature review.


RESULTS
We describe a case of localized melanosis in an immunocompromised patient without evidence of systemic metastases. The patient underwent limb perfusion and her immunosuppressive therapy has been stopped. The melanosis has not regressed; however, there has been no systemic involvement and her transplanted kidney is still functioning well.


CONCLUSIONS
To our knowledge this is the first report of this phenomenon in an immunocompromised host.
Carruth
Marc R
MR
Skin and Mohs Surgery Center, Kansas City, Missouri, USA.
Goldstein
Glenn D
GD
Tillman
Donald K
DK
D000368:Aged; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008545:Melanoma / Q000150:complications / Q000473:pathology*; D008548:Melanosis / Q000276:immunology*; D012878:Skin Neoplasms / Q000150:complications / Q000556:secondary*