title: Involvement of serotonin in nicotine dependence: processes relevant to positive and negative regulation of drug intake.
abstract: The neurobiological substrate of nicotine dependence has been the subject of extensive preclinical and clinical research. Many experimental reports have implicated the brain serotonin (5-HT) systems in processes relevant to nicotine dependence, but the specific role of this neurotransmitter system largely remains to be elucidated. This review will focus on the role of 5-HT in the acute and chronic effects of nicotine. In particular, the evidence for a role of 5-HT neurotransmission in brain processes thought to be involved in positive and negative control of nicotine use will be examined, and potential clinical implications discussed.
authors.affiliation: Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, 34 Park Street, New Haven, CT 06508, USA. peter.olausson@yale.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Olausson
authors.forename: Jörgen A
authors.initials: JA
authors.lastname: Engel
authors.forename: Bo
authors.initials: B
authors.lastname: Söderpalm
mesh_terms: D000428:Alcohol Drinking / Q000523:psychology; D000818:Animals; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D012054:Reinforcement, Psychology; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects; D014029:Tobacco Use Disorder / Q000503:physiopathology* / Q000523:psychology
chemical_list: D012701:Serotonin; D004298:Dopamine