Mafenide acetate allergy presenting as recurrent chondritis.
Acute chondritis has a strong predilection for recurrence. Mafenide acetate has been implicated in causing reactions that mimic this condition; however, these hypersensitivity reactions lack fever, fluctuance, and pain. The authors report a case of mafenide acetate allergy presenting as recurrent chondritis in a patient who had previously been treated successfully for this condition. In this patient, the allergic response resolved within 3 days after cessation of mafenide acetate. If unappreciated, it may have led to unnecessary operative intervention. Therefore, auricular edema and erythema, without fever, fluctuance, and pain, must be recognized by surgeons as a possible mafenide acetate allergy and must be considered in the differential diagnosis for patients who present with recurrent acute suppurative chondritis.
Pickus
Evan J
EJ
Division of Plastic Surgery, University of Kansas Medical Center, Kansas City 66160, USA.
Lionelli
Gerald T
GT
Charles
E Woodall
EW
Korentager
Richard A
RA
D000328:Adult; D000891:Anti-Infective Agents, Local / Q000009:adverse effects* / Q000627:therapeutic use; D002056:Burns / Q000188:drug therapy; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D004431:Ear, External / Q000293:injuries; D006801:Humans; D008272:Mafenide / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010007:Osteochondritis / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D010032:Otitis Externa / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D012008:Recurrence; D013638:Tars / Q000009:adverse effects; D016896:Treatment Outcome
D000891:Anti-Infective Agents, Local; D013638:Tars; D008272:Mafenide