title: Body surface area and body weight predict total liver volume in Western adults.
abstract: Computed tomography (CT) is used increasingly to measure liver volume in patients undergoing evaluation for transplantation or resection. This study is designed to determine a formula predicting total liver volume (TLV) based on body surface area (BSA) or body weight in Western adults. TLV was measured in 292 patients from four Western centers. Liver volumes were calculated from helical computed tomographic scans obtained for conditions unrelated to the hepatobiliary system. BSA was calculated based on height and weight. Each center used a different established method of three-dimensional volume reconstruction. Using regression analysis, measurements were compared, and formulas correlating BSA or body weight to TLV were established. A linear regression formula to estimate TLV based on BSA was obtained: TLV = -794.41 + 1,267.28 x BSA (square meters; r(2) = 0.46; P <.0001). A formula based on patient weight also was derived: TLV = 191.80 + 18.51 x weight (kilograms; r(2) = 0.49; P <.0001). The newly derived TLV formula based on BSA was compared with previously reported formulas. The application of a formula obtained from healthy Japanese individuals underestimated TLV. Two formulas derived from autopsy data for Western populations were similar to the newly derived BSA formula, with a slight overestimation of TLV. In conclusion, hepatic three-dimensional volume reconstruction based on helical CT predicts TLV based on BSA or body weight. The new formulas derived from this correlation should contribute to the estimation of TLV before liver transplantation or major hepatic resection.
authors.affiliation: Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. jvauthey@mdanderson.org
authors.forename: Jean-Nicolas
authors.initials: JN
authors.lastname: Vauthey
authors.forename: Eddie K
authors.initials: EK
authors.lastname: Abdalla
authors.forename: Dorota A
authors.initials: DA
authors.lastname: Doherty
authors.forename: Philippe
authors.initials: P
authors.lastname: Gertsch
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Fenstermacher
authors.forename: Evelyne M
authors.initials: EM
authors.lastname: Loyer
authors.forename: Jan
authors.initials: J
authors.lastname: Lerut
authors.forename: Roland
authors.initials: R
authors.lastname: Materne
authors.forename: Xuemei
authors.initials: X
authors.lastname: Wang
authors.forename: Arthur
authors.initials: A
authors.lastname: Encarnacion
authors.forename: Delise
authors.initials: D
authors.lastname: Herron
authors.forename: Christian
authors.initials: C
authors.lastname: Mathey
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ferrari
authors.forename: Chuslip
authors.initials: C
authors.lastname: Charnsangavej
authors.forename: Kim-Anh
authors.initials: KA
authors.lastname: Do
authors.forename: Alban
authors.initials: A
authors.lastname: Denys
mesh_terms: D000328:Adult; D001830:Body Surface Area; D001835:Body Weight; D005544:Forecasting; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008099:Liver / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D008875:Middle Aged; D008953:Models, Anatomic; D009929:Organ Size; D012044:Regression Analysis; D014057:Tomography, X-Ray Computed; D019366:Western World