title: Localized melanosis in an immunocompromised patient with local metastatic melanoma.
abstract: BACKGROUND
  Melanosis is a rare, but well recognized late complication of some cases of metastatic melanoma. The precise pathogenesis is unclear. Most described cases report diffuse metastases and diffuse melanosis.
  
  
  OBJECTIVE
  To present a case of localized melanosis secondary to locally metastatic melanoma without evidence of systemic involvement in a renal transplant patient.
  
  
  METHODS
  Case report and literature review.
  
  
  RESULTS
  We describe a case of localized melanosis in an immunocompromised patient without evidence of systemic metastases. The patient underwent limb perfusion and her immunosuppressive therapy has been stopped. The melanosis has not regressed; however, there has been no systemic involvement and her transplanted kidney is still functioning well.
  
  
  CONCLUSIONS
  To our knowledge this is the first report of this phenomenon in an immunocompromised host.
authors.affiliation: Skin and Mohs Surgery Center, Kansas City, Missouri, USA.
authors.forename: Marc R
authors.initials: MR
authors.lastname: Carruth
authors.forename: Glenn D
authors.initials: GD
authors.lastname: Goldstein
authors.forename: Donald K
authors.initials: DK
authors.lastname: Tillman
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008545:Melanoma / Q000150:complications / Q000473:pathology*; D008548:Melanosis / Q000276:immunology*; D012878:Skin Neoplasms / Q000150:complications / Q000556:secondary*