title: Treatment of hyperhomocysteinemia with folic acid reduces oxidative stress in renal transplant recipients.
abstract: BACKGROUND
  We conducted a prospective, uncontrolled, open study to assess the relationship between homocysteine (tHcy) and oxidative stress in chronic, stable, renal transplant recipients (RTR).
  
  
  METHODS
  Included in the study were 17 chronic, stable RTR. All the patients received folic acid (5 mg/day). tHcy and total antioxidant capacity (TAOC) were measured before and at the end of the study period.
  
  
  RESULTS
  Mean tHcy concentration was 26+/-10 micromol/L. tHcy significantly decreased during the study period (26+/-10 vs. 18+/-7 micromol/L; P<0.001). There was a significant inverse relationship between TAOC and tHcy (r= -0.33; P=0.01). TAOC significantly increased during the study period (1.49+/-0.23-1.78+/-0.6; P<0.001). There was an inverse relationship between the variation in tHcy and the variation in TAOC (r= -0.44; P=0.01).
  
  
  CONCLUSIONS
  Our results demonstrate that hyperhomocysteinemia contributed to increased oxidative stress in RTR. tHcy-lowering treatment with folic acid may lower oxidative stress.
authors.affiliation: Department of Nephrology and Renal Transplantation, University Hospital, Besançon, France.
authors.forename: Aboubakr
authors.initials: A
authors.lastname: Abdelfatah
authors.forename: Didier
authors.initials: D
authors.lastname: Ducloux
authors.forename: Gérard
authors.initials: G
authors.lastname: Toubin
authors.forename: Gérard
authors.initials: G
authors.lastname: Motte
authors.forename: Daniel
authors.initials: D
authors.lastname: Alber
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Chalopin
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D005215:Fasting; D005260:Female; D005492:Folic Acid / Q000097:blood / Q000627:therapeutic use*; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000188:drug therapy*; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011183:Postoperative Complications / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000975:Antioxidants; D006710:Homocysteine; D005492:Folic Acid