FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses.
The inactivation of the mouse high-affinity IgG Fc receptor FcgammaRI resulted in a wide range of defects in antibody Fc-dependent functions. These studies showed the primary importance of FcgammaRI in endocytosis of monomeric IgG, kinetics, and extent of phagocytosis of immune complexes, in macrophage-based ADCC, and in immune complex-dependent antigen presentation to primed T cells. In the absence of FcgammaRI, antibody responses were elevated, implying the removal of a control point by the deletion of FcgammaRI. In addition, FcR-gamma chain-deficient mice were found to express partially functional FcgammaRI. Thus, FcgammaRI is an early participant in Fc-dependent cell activation and in the development of immune responses.
Barnes
Nadine
N
The Austin Research Institute, Kronheimer Building, Studley Road, Heidelberg, Victoria 3084, Australia.
Gavin
Amanda L
AL
Tan
Peck Szee
PS
Mottram
Patricia
P
Koentgen
Frank
F
Hogarth
P Mark
PM
D000818:Animals; D017353:Gene Deletion; D007109:Immunity / Q000235:genetics; D007249:Inflammation / Q000235:genetics; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D051379:Mice; D017452:Receptors, IgG / Q000172:deficiency / Q000235:genetics* / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D017452:Receptors, IgG