title: [Semiquantitative analysis of bone regeneration on porous metallic wire-mesh specimens with or without HA-coating in comparison to pure titanium in animal experiments].
abstract: BACKGROUND
  The aim of this study was to analyse the bone regeneration on porous metallic wire-mesh specimens of pure titanium, uncoated CoCrMb and HA-coated CoCrMb in a comparative animal experiment.
  
  
  METHODS
  Uncoated and hydroxyapatite-coated CoCrMb (one-sided) specimens were tested in an animal experiment. The statistical interpretation was done macroscopically as well as microscopically.
  
  
  RESULTS
  With regard to the histological and quantitative evaluation, it has been shown that the proximal coated CrCoMb implants were superior to the other specimen. The bone regeneration with the most distinctive extent of osseointegration has been seen by the HA-coated CrCoMb specimen. The uncoated distal CoCrMb specimen demonstrated the worst results.
  
  
  CONCLUSIONS
  This study shows that specimens of titanium and uncoated CrCoMb implanted at the proximal metaphysis deliver comparable effects on the bone regeneration and osseointegration. The best results with regard to the bone regeneration and osseointegration were seen with the implanted hydroxyadaptite-coated CrCoMb specimen. In addition, it has been observed that the bone regeneration and osseointegration of the specimen depends on the place of implantation.
authors.affiliation: Orthopädische Klinik der Philipps-Universität Marburg, Germany. Wilke@post.med.uni-marburg.de
authors.forename: A
authors.initials: A
authors.lastname: Wilke
authors.forename: A
authors.initials: A
authors.lastname: Richter
authors.forename: F
authors.initials: F
authors.lastname: Traub
authors.forename: S
authors.initials: S
authors.lastname: Endres
authors.forename: J
authors.initials: J
authors.lastname: Orth
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D001864:Bone Wires; D001842:Bone and Bones / Q000473:pathology; D020099:Coated Materials, Biocompatible; D017886:Durapatite; D005260:Female; D016348:Osseointegration / Q000502:physiology*; D019736:Prostheses and Implants; D013526:Surgical Mesh; D013556:Swine, Miniature; D014025:Titanium; D014800:Vitallium
chemical_list: D020099:Coated Materials, Biocompatible; D014800:Vitallium; D017886:Durapatite; D014025:Titanium