title: [Which patients with acute coronary syndrome without ST segment elevation should be handled invasively/interventionally when?].
abstract: Until recently the therapeutic approach in patients with acute coronary syndrome without ST-segment elevation focused on medical stabilization. Usually cardiac catheterization and revascularisation were performed later only if the stabilized patient had provoked ischemia. Since angioplasty became safer with the introduction of coronary stents, and since new potent antithrombotic agents (i.e. tienopyridines or glycoprotein-receptorIIb/IIIa-antagonists) have been developed, early angioplasty has become much more effective. Moreover major progress has been made in risk-stratification, which allow an individual therapeutic strategy for each patient according to his risk-status. We discuss the most important randomised clinical trials comparing a conservative versus an invasive strategy and introduce a new algorithm for risk-stratification und therapy in acute coronary syndromes without ST-elevation.
authors.affiliation: Abteilung für Kardiologie, Bereich Innere Medizin I, Kantonsspital Basel. ckaiser@uhbs.ch
authors.forename: C
authors.initials: C
authors.lastname: Kaiser
authors.forename: N
authors.initials: N
authors.lastname: Balmelli
authors.forename: M
authors.initials: M
authors.lastname: Pfisterer
mesh_terms: D000789:Angina, Unstable / Q000175:diagnosis / Q000628:therapy*; D004562:Electrocardiography; D006801:Humans; D009204:Myocardial Revascularization; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex