A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis.
Xerotic skin is a pattern of reaction to a variety of disorders that have abnormalities of desquamation in common. This double-blind, randomized clinical trial investigated the effect of Lactinol (Pedinol Pharmaceuticals, Farmingdale, New York) versus Lac-Hydrin 12% (Bristol-Myers Squibb, Princeton, New Jersey) lotion in mild to moderate foot xerosis. Clinical assessment of xerosis was performed at baseline visit, and the designated sites were evaluated at 2 and 4 weeks after treatment began. Of the 53 patients enrolled, 18 were excluded from analysis. Although both treatment groups had significantly improved xerosis scores after 2 and 4 weeks of treatment, no statistically significant difference was observed. Of the 44% of patients who did express a preference, 72% preferred Lactinol, which may account for the 20% increase in its overall use in the study.
Jennings
Maureen B
MB
New York College of Podiatric Medicine, New York, NY 10035, USA.
Logan
Loretta
L
Alfieri
Donna M
DM
Ross
Charles F
CF
Goodwin
Susan
S
Lesczczynski
Christine
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D004890:Erythema / Q000139:chemically induced; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy*; D006801:Humans; D019344:Lactic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000139:chemically induced; D000644:Quaternary Ammonium Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
D003879:Dermatologic Agents; D000644:Quaternary Ammonium Compounds; D019344:Lactic Acid; C114389:Lac-Hydrin