Phomadecalins A-D and phomapentenone A: new bioactive metabolites from Phoma sp. NRRL 25697, a fungal colonist of Hypoxylon stromata.
Five new natural products, phomadecalins A-D (1-4) and phomapentenone A (5), have been obtained from cultures of Phoma sp. (NRRL 25697), a fungal colonist isolated from the stromata of Hypoxylon sp. The structures of these compounds were elucidated through a series of 1D and 2D NMR experiments. Compounds 1-4 display activity against Gram-positive bacteria.
Che
Yongsheng
Y
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Gloer
James B
JB
Wicklow
Donald T
DT
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001231:Aspergillus flavus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D003517:Cyclopentanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry*; D005670:Fusarium / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013210:Staphylococcus / Q000187:drug effects
D000935:Antifungal Agents; D003517:Cyclopentanes; C455759:phomapentenone A