[Serum and peritoneal fluid CA-125 concentration in women with endometriosis].
OBJECTIVE
To evaluate the clinical utility of CA-125 measurements in peritoneal fluid (PF) as an indicator of endometriosis.


METHODS
CA-125 levels in paired serum and peritoneal fluid were assessed by IMx CA-125 Assay (ABBOTT).


METHODS
107 women with and without endometriosis, undergoing laparoscopy during the luteal phase of the menstrual cycle were selected for the study.


RESULTS
CA-125 levels in peritoneal fluid were higher than those found in serum and were significantly elevated (P < 0.05) in comparison to the control group. In women with endometriosis stage I-II and stage III-IV. CA-125 levels in serum were increased only in stage III-IV.


CONCLUSIONS
The sensitivity of the peritoneal fluid CA-125 test for endometriosis is higher than the respective serum test. The measurement of CA-125 levels in PF could be useful in the detection of the early stage endometriosis, which seems to be missed by the CA-125 serum test.
Kraśnicki
D
D
Wolontariusz II Katedry i Kliniki Ginekologii, II Katedry i Kliniki Ginekologii A M we Wrocławiu.
D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism*; D018394:CA-125 Antigen / Q000097:blood / Q000378:metabolism*; D016022:Case-Control Studies; D004715:Endometriosis / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008183:Luteal Phase / Q000378:metabolism; D008597:Menstrual Cycle / Q000378:metabolism; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D018394:CA-125 Antigen