title: mar Operon involved in multidrug resistance of Enterobacter aerogenes.
abstract: We determined the sequence of the entire marRAB operon in Enterobacter aerogenes. It is functionally and structurally analogous to the Escherichia coli operon. The overexpression of E. aerogenes MarA induces a multidrug resistance phenotype in a susceptible strain, demonstrated by a noticeable resistance to various antibiotics, a decrease in immunodetected porins, and active efflux of norfloxacin.
authors.affiliation: Enveloppe Bactérienne, Antibiotiques et Colonisation, CJF 9606-EA 2197, Facultés de Médecine et Pharmacie, Université de la Méditerranée, 13385 Marseille Cedex 05, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: Chollet
authors.forename: Claude
authors.initials: C
authors.lastname: Bollet
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Chevalier
authors.forename: Monique
authors.initials: M
authors.lastname: Malléa
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Pagès
authors.forename: Anne
authors.initials: A
authors.lastname: Davin-Regli
mesh_terms: D000595:Amino Acid Sequence; D000890:Anti-Infective Agents / Q000378:metabolism; D004269:DNA, Bacterial / Q000032:analysis / Q000737:chemistry; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D004591:Electrophoresis, Polyacrylamide Gel; D004754:Enterobacter / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D008969:Molecular Sequence Data; D009643:Norfloxacin / Q000378:metabolism; D009876:Operon / Q000235:genetics*; D018272:Porins / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D000890:Anti-Infective Agents; D004269:DNA, Bacterial; D018272:Porins; D009643:Norfloxacin