title: A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation.
abstract: ComK, the master regulator of competence, is degraded by the general stress-related protease ClpCP but must be targeted to this protease by binding to the adapter protein MecA. The genome of Bacillus subtilis contains a paralog of mecA, ypbH. We show in the present study that YpbH, like MecA, binds ClpC and that its elimination or overproduction affects competence and sporulation.
authors.affiliation: Public Health Research Institute, New York, New York 10016, USA.
authors.forename: Marjan
authors.initials: M
authors.lastname: Persuh
authors.forename: Ines
authors.initials: I
authors.lastname: Mandic-Mulec
authors.forename: David
authors.initials: D
authors.lastname: Dubnau
mesh_terms: D001412:Bacillus subtilis / Q000235:genetics / Q000502:physiology*; D001426:Bacterial Proteins / Q000378:metabolism* / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D013171:Spores, Bacterial / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; C087481:ClpC protein, Bacteria; D006360:Heat-Shock Proteins; C083616:mecA protein, Bacillus subtilis