[Validation of the optimal concentration of Metrogil-denta preparation in the treatment of periodontal inflammations].
Fifty-two patients (22-68 years) with chronic generalized periodontitis of different severity and 223 with fulminant severe periodontitis were observed. The bacteriostatic and bactericidal effects of Metrogil-denta depended on the severity of periodontal involvement and metronidasole concentration in the drug. The maximum bacteriostatic effect was observed at 20-25% and the maximum bactericidal effect at 25% concentration of metronidasole in the preparation irrespective of periodontitis severity.
Grudianov
A I
AI
Dmitrieva
N A
NA
Ovchinnikova
V V
VV
D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D010518:Periodontitis / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index
D000890:Anti-Infective Agents; D004338:Drug Combinations; D008795:Metronidazole