title: Pericarditis and pericardial effusion in acute ST-elevation myocardial infarction in the thrombolytic era.
abstract: BACKGROUND
  Myocardial infarction-associated pericarditis is a common cause of chest pain following MI, its frequency depending on how it is defined.
  
  
  OBJECTIVE
  To investigate the incidence of acute pericarditis and pericardial effusion in the acute phase of ST-elevation MI treated with thrombolytic therapy.
  
  
  METHODS
  The study group comprised 159 consecutive patients fulfilling the criteria for acute MI who were admitted to our department during 18 months. Infarct-associated pericarditis was defined as the finding of a pericardial friction rub, a typical pleuropericardial pain, or both. All patients underwent physical examination of the cardiovascular system four times daily for 7 days, as well as daily electrocardiogram and echo Doppler examinations.
  
  
  RESULTS
  Fourteen patients (8.8%) developed a friction rub and 11 patients (6.9%) had a mild pericardial effusion. Six patients (4.0%) had both a friction rub and pericardial effusion. Two patients had a friction rub for more than 7 days. Pleuropericardial chest pain was present in 31 patients (19.5%) but only 7 of them had a friction rub. The in-hospital mortality rate was 1.3% and no mortality was observed in the acute pericarditis group.
  
  
  CONCLUSIONS
  The incidence of signs associated with acute pericarditis was lower in MI patients treated with thrombolysis, compared with historical controls, when a friction rub and/or pericardial effusion was present. There was no significant reduction in the incidence of pleuropericardial chest pain.
authors.affiliation: Department of Cardiology, Western Galilee Hospital, Nahariya, Israel.
authors.forename: Alp
authors.initials: A
authors.lastname: Aydinalp
authors.forename: Alice
authors.initials: A
authors.lastname: Wishniak
authors.forename: Lily
authors.initials: L
authors.lastname: van den Akker-Berman
authors.forename: Tsafrir
authors.initials: T
authors.lastname: Or
authors.forename: Nathan
authors.initials: N
authors.lastname: Roguin
mesh_terms: D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000188:drug therapy; D010490:Pericardial Effusion / Q000209:etiology*; D010493:Pericarditis / Q000209:etiology*; D011446:Prospective Studies
chemical_list: D005343:Fibrinolytic Agents