title: Iron overloading inhibits endochondral ossification.
abstract: The development of bone disease in patients with chronic renal failure is well known. Renal patients frequently suffer anemia and iron oral therapy and/or transfusions are used to treat them. Recent findings show that iron could be a factor that provokes bone lesions but the alterations it causes are not well known. The aim of this work was to study the effect of iron intoxication on endochondral ossification, a recognized model for bone growth evaluation. Male Wistar rats weighing 250-300 g were used. They received 88 mg of dextran-iron per day intraperitoneally during 34 days. The experimental and control groups were killed on day 34. A histomorphometric study of the endochondral plate was performed on histologic sections of tibiae. The results obtained show that iron overloading inhibits endochondral ossification.
authors.affiliation: Department of Histology, Department of Pathology, School of Dentistry, University of Buenos Aires, Argentina.
authors.forename: P M
authors.initials: PM
authors.lastname: Mandalunis
authors.forename: R L
authors.initials: RL
authors.lastname: Cabrini
authors.forename: A M
authors.initials: AM
authors.lastname: Ubios
mesh_terms: D000818:Animals; D006132:Growth Plate / Q000187:drug effects* / Q000503:physiopathology; D007501:Iron / Q000633:toxicity*; D019190:Iron Overload / Q000503:physiopathology*; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia
chemical_list: D007501:Iron