Mpv37 mouse strain--a model for the relationship between the kidney and the inner ear.
Using the Mpv17-negative mouse strain, which developed inner ear and kidney dysfunction, we confirm a strong relationship between the kidney and the inner ear. Both organs have specialized epithelia involved in active ion transport, which are separated from the vessels by a basement membrane of similar composition. Our recent results indicate that the glomerular and the stria vascularis basement membrane are simultaneously affected in early stages. Concomitant deposits of IgG during the progressive development of the disease support the idea of a shared antigen. Understanding the pattern of the development of the degeneration will provide a basis towards understanding the essential role of the Mpv17 protein in the structures of both organs and may provide a basis for future therapeutic intervention.
Meyer zum Gottesberge
Angela M
AM
Department of Otorhinolaryngology, University of Düsseldorf, Germany. gottesbe@uni-duesseldorf.de
Balz
V
V
Felix
Heidi
H
D000818:Animals; D001284:Atrophy / Q000378:metabolism / Q000473:pathology; D015834:Cochlear Diseases / Q000235:genetics* / Q000473:pathology; D007074:Immunoglobulin G / Q000276:immunology; D007150:Immunohistochemistry; D007674:Kidney Diseases / Q000235:genetics* / Q000473:pathology; D008565:Membrane Proteins; D051379:Mice; D008817:Mice, Mutant Strains; D008854:Microscopy, Electron; D011506:Proteins / Q000378:metabolism*; D013316:Stria Vascularis / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure
D007074:Immunoglobulin G; D008565:Membrane Proteins; C065292:Mpv17 protein, mouse; D011506:Proteins