Role of substance P in the peripheral vestibular and auditory system.
The central role of substance P (SP) has attracted growing interest in the past two decades. One of the important physiological functions of SP and other tachykinins is that of a neurotransmitter in primary afferent neurons. Recent immunocytochemical, biochemical and electrophysiological investigations on various neurotransmitters support the hypothesis that SP has a similar function in the vestibular and auditory systems of all mammals including humans. The purpose of this review is to give an overview of the distribution and concomitant physiological functions of this peptide in these sensory systems.
Felix
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ENT Department, University Hospital Zürich, Switzerland. felix@orl.usz.ch
Oestreicher
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Felix
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Ehrenberger
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D001303:Auditory Cortex / Q000378:metabolism / Q000502:physiology*; D003051:Cochlea / Q000502:physiology; D006199:Hair Cells, Auditory, Inner / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D016202:N-Methylaspartate / Q000378:metabolism; D013373:Substance P / Q000378:metabolism / Q000502:physiology*; D014725:Vestibular Nerve / Q000378:metabolism / Q000648:ultrastructure; D014722:Vestibule, Labyrinth / Q000378:metabolism / Q000502:physiology*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000378:metabolism
D013373:Substance P; D016202:N-Methylaspartate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid