title: Exercise response to simulated weightlessness.
abstract: Two bed rest analog studies of space flight were performed; one 14 d and the other 28 d in duration. Exercise response was studied in detail during the 28 d study and following both the 14 d and 28 d studies. This paper relates the results of these studies to physiologic changes noted during and following space flight. The most consistent change noted after both bed rest and space flight is an elevated heart rate during exercise. A second consistent finding is a postflight or postbed rest reduction in cardiac stroke volume. Cardiac output changes were variable. The inability to simulate inflight activity levels and personal exercise makes a direct comparison between bed rest and the results from specific space flights difficult.
authors.affiliation: Lyndon B. Johnson Space Center, National Aeronautics and Space Administration, Houston, TX 77058, USA.
authors.forename: C F
authors.initials: CF
authors.lastname: Sawin
authors.forename: J A
authors.initials: JA
authors.lastname: Rummel
authors.forename: M C
authors.initials: MC
authors.lastname: Buderer
mesh_terms: D000328:Adult; D001510:Bed Rest; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D018493:Cardiovascular Deconditioning / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D011187:Posture / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D016683:Supine Position; D018474:Weightlessness Simulation