[Progress in telomerase and the inhibitors].
In cells division chromosome length is shorten for the ending DNA couldn't be replicated completely, and the loss of telomere DNA will lead to senescence and death. Activation of telomerase can elongate telomere length and maintain gene stability. Up-regulation of telomerase is considered to be responsible for immortalization and carcinogenesis. It plays an important role in cell-span and cell division. The telomerase inhibitors will become efficient drugs in tumor therapy.
Zhou
Y
Y
Department of Biological Science and Technology, Zhejiang University, Hangzhou 310027, China.
Gong
X G
XG
D000818:Animals; D004354:Drug Screening Assays, Antitumor; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D020135:Peptide Nucleic Acids / Q000494:pharmacology; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D016615:Telomere / Q000187:drug effects / Q000378:metabolism*; D014212:Tretinoin / Q000494:pharmacology; D015854:Up-Regulation
D004791:Enzyme Inhibitors; D020135:Peptide Nucleic Acids; D014212:Tretinoin; D019098:Telomerase