title: Pharmacology and toxicology of astrocyte-neuron glutamate transport and cycling.
abstract: The interaction between astrocytes and neurons is examined from the standpoint of glutamate neurotoxicity. The review details 1. the distribution of glutamate transporters on astrocytes and neurons, provoking a reformulation of the interdependence between these two cell types in removing extracellular glutamate and preventing excitotoxic injury; 2. the potential involvement of aberrant glutamate transporter function in the etiology of neuropathological conditions; 3. the role of astrocyte-neuron interaction in widely divergent aspects of brain energetics; 4. the role of astrocytes in the process of glutamate recycling within the context of anesthetic treatment with pentobarbital and thiopental.
authors.affiliation: Department of Clinical Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Ursula
authors.initials: U
authors.lastname: Sonnewald
authors.forename: Hong
authors.initials: H
authors.lastname: Qu
authors.forename: Michael
authors.initials: M
authors.lastname: Aschner
mesh_terms: D027322:Amino Acid Transport System X-AG / Q000378:metabolism; D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism*; D001693:Biological Transport, Active / Q000187:drug effects; D018757:GABA Modulators / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D013874:Thiopental / Q000494:pharmacology
chemical_list: D027322:Amino Acid Transport System X-AG; D018757:GABA Modulators; D018698:Glutamic Acid; D005947:Glucose; D013874:Thiopental