Leptin and estradiol as related to change in pubertal status and body weight.
BACKGROUND
Previous studies have examined the relationship between leptin, body mass, and pubertal status. The present study directly compares the relationship of leptin and estradiol in 5 groups of girls with different combinations of pubertal status and weight.


METHODS
We studied girls with idiopathic precocious puberty, age-matched non-obese prepubertal girls, age-matched obese prepubertal girls, normal pubertal girls, and obese pubertal girls (n=12/group).


RESULTS
Leptin levels were significantly higher in obese pubertal girls (26.6+/-8.4 ng/mL) than in all others. Leptin levels were significantly higher in obese prepubertal girls (20.7+/-10.9 ng/mL) (mean+/-SD) compared to girls with precocious puberty (7.7+/-5.4 ng/mL, p<0.004), non-obese prepubertal girls (5.55+/-3.6 ng/mL, p<0.001), and normal pubertal girls (4.8+/-2.9 ng/mL, p<0.001). Leptin level did not correlate significantly with estradiol level. Leptin-SDS (standard deviation score), which corrects leptin level for gender, pubertal stage, and BMI, was significantly lower in the obese pubertal group than in the 3 non-obese groups.


CONCLUSIONS
These findings confirm previous studies that body mass, chronological age and pubertal stage are determinants of leptin level. However, these are not the only factors determining leptin level as evidenced by persistent differences in leptin level between obese and non-obese pubertal girls even when correcting for pubertal stage and BMI. While the present study provides no new answers to the question of pubertal regulation, it provides a direct comparison of combinations of weight, pubertal stage, and leptin level, as background for future studies.
Larmore
Kimberly A
KA
Departments of Pediatrics and Clinical Research, A.I duPont Hospital for Children/ Nemours Children's Clinic, Wilmington, DE, USA.
O'Connor
Darlise
D
Sherman
Tami Irwin
TI
Funanage
Vicky L
VL
Hassink
Sandra G
SG
Klein
Karen Oerter
KO
D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D002648:Child; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D009765:Obesity / Q000097:blood; D011627:Puberty; D011629:Puberty, Precocious / Q000097:blood
D020738:Leptin; D004958:Estradiol