Effects of SM-20550, a new Na(+)/H(+) exchange inhibitor, on survival and infarct size in rat myocardial infarction.
The effect of a novel potent Na(+)/H(+) exchange inhibitor, SM-20550 [N-(aminoiminomethyl)-1,4-dimethyl-1H-indole-2-carboxamide methanesulfonic acid], on survival after myocardial infarction was studied. Anesthetized rats underwent occlusion of the coronary artery (30 min) followed by reperfusion (14 days). SM-20550 was administered intravenously before ischemia (1-day treatment group) or before ischemia and on the 2 days following (3-day treatment group). The infarct size was significantly reduced on the 14th day after surgery by approximately 17 and 20% in 1- and 3-day treatment groups, respectively. The survival rate on day 14 was significantly enhanced in both treatment groups (96%) compared with the vehicle-treated control group (70%). These results suggest that SM-20550 improved survival after myocardial infarction, at least due to its antinecrotic effect.
Yamada
Kazuto
K
Sumitomo Pharmaceutical Research Center, Osaka, Japan. yamadak@sumitomopharm.co.jp
Sasabe
Masao
M
Matsui
Kazuki
K
Yamamoto
Setsuko
S
Ohashi
Naohito
N
D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D009203:Myocardial Infarction / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D009206:Myocardium / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D017923:Sodium-Hydrogen Exchangers / Q000037:antagonists & inhibitors; D015996:Survival Rate; D013997:Time Factors
D000578:Amidines; D007211:Indoles; C121094:SM 20550; D017923:Sodium-Hydrogen Exchangers