title: [HindIII DNA-polymorphism of lipoprotein lipase gene in elderly patients with ischemic heart disease].
abstract: OBJECTIVE
  To determine incidence of HindIII alleles of lipoprotein lipase (LPL) in Russian elderly patients with stable effort angina (SEA) functional class II-III regarding lipid metabolism.
  
  
  METHODS
  Genotyping by LPL gene was performed in 103 patients with SEA. Of them 13 patients survived myocardial infarction (MI), 29 patients had diabetes mellitus.
  
  
  RESULTS
  Incidence of alleles of HindIII DNA-polymorphism of LPL gene both in healthy and IHD patients is comparable with that in the West European populations.
  
  
  CONCLUSIONS
  Genotype H+H+ of LPL gene is one of the markers of predisposition to MI, while allele H- is one of the resistance marks.
authors.forename: N A
authors.initials: NA
authors.lastname: Malygina
authors.forename: I V
authors.initials: IV
authors.lastname: Kostomarova
authors.forename: G V
authors.initials: GV
authors.lastname: Deriagin
authors.forename: L D
authors.initials: LD
authors.lastname: Serova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000150:complications / Q000235:genetics; D004247:DNA / Q000235:genetics*; D015247:Deoxyribonuclease HindIII; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D004587:Electrophoresis, Agar Gel; D005260:Female; D005838:Genotype; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics; D017202:Myocardial Ischemia / Q000150:complications / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D004247:DNA; D008071:Lipoprotein Lipase; D015247:Deoxyribonuclease HindIII