Regulation of allergic airways inflammation by cytokines and glucocorticoids.
Cytokines mediate the allergic inflammatory response of the airways, and glucocorticosteroids ameliorate allergy symptoms by regulating cytokine expression. Recent studies provide insight into the manner by which cytokines work together to mediate allergic airway disease. Real progress has also been gained in our understanding of subcellular mechanisms of allergic inflammation, particularly the role of transcription factors in regulating the expression of specific cytokine profiles and the differentiation of the TH2 subset. This article provides an update of recently reported findings in this field and highlights emerging concepts of allergic inflammation.
Cameron
L
L
Respiratory Sciences Center, University of Arizona, Tucson, AZ, USA.
Hamid
Q
Q
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis*; D005938:Glucocorticoids / Q000096:biosynthesis*; D006801:Humans; D011014:Pneumonia / Q000209:etiology / Q000503:physiopathology*; D012130:Respiratory Hypersensitivity / Q000209:etiology / Q000503:physiopathology*
D016207:Cytokines; D005938:Glucocorticoids