[Changes in the endocrine system in the course of sulpiride therapy].
The influence of sulpiride, a neuroleptic included into the group of benzamide derivatives, upon endocrine system has been discussed in the article. It is noted that sulpiride clearly increases the evolution of prolactin in both sexes. It gives a chain of various consequences. They are, among others, impairment of gonad activity in both sexes which causes emmeniopathy and galactorrhea in women and impotence in men. The influence of hyperprolactinemia, caused by sulpiride, upon the level of testosterone in plasma and also upon the evolution of progesterone has been also discussed. The knowledge of the influence of sulpiride upon endocrine system is necessary for physicians applying therapy by this medicine. In the article the analysis has been carried out how wider and wider used neuroleptic-sulpiride--influences upon endocrine system and particularly upon the evaluation of prolactin. In the article the main methods of action of the known neuroleptic-sulpiride have been discussed. This is an antiautistic, activizing, antipsychotic and antidepressive action. The other authors used sulpiride in therapy of depressive endogenic syndrome. They obtained a good therapeutic effect. The drug distribution in human organism was also taken into consideration. The mechanism of action of sulpiride and its extrapsychiatric application was also mentioned. The other authors often combines the drug with benzodiazepine derivatives which soothe the fear characteristic of depression.
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Zespól Publicznych Zakładów Opieki Zdrowotnej Warszawa-Zoliborz.
D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy; D018492:Dopamine Antagonists / Q000009:adverse effects*; D004703:Endocrine System / Q000187:drug effects*; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced*; D008297:Male; D011388:Prolactin / Q000187:drug effects; D013469:Sulpiride / Q000009:adverse effects*
D018687:Antidepressive Agents, Second-Generation; D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D013469:Sulpiride; D011388:Prolactin