Focus on clozapine.
Clozapine is a dibenzodiazepine derivative and a truly atypical anti-psychotic. Its therapeutic effects are probably mediated by dopaminergic and serotonergic activity. Although it appears to be the most effective antipsychotic drug for treatment-resistant schizophrenia, its general use is limited because of the risk of agranulocytosis.
Naheed
M
M
Hollins Park Hospital, Warrington, Cheshire, UK.
Green
B
B
D000380:Agranulocytosis / Q000139:chemically induced; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D003024:Clozapine / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D012559:Schizophrenia / Q000188:drug therapy*
D014150:Antipsychotic Agents; D003024:Clozapine