Coactivators in transcription initiation: here are your orders.
Coactivators are diverse and multifunctional proteins that act downstream of DNA-binding activators to stimulate transcription. Recent studies elucidate the temporal sequence in which coactivators are recruited to target promoters, and how their enzymatic properties and molecular interactions culminate in transcriptional initiation.
Featherstone
Mark
M
McGill Cancer Centre, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada. mfeather@med.mcgill.ca
D000123:Acetyltransferases / Q000502:physiology; D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D051548:Histone Acetyltransferases; D006657:Histones / Q000502:physiology; D006801:Humans; D010766:Phosphorylation; D012319:RNA Polymerase II / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D015398:Signal Transduction / Q000502:physiology; D035181:TATA-Box Binding Protein; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*
D004268:DNA-Binding Proteins; D006657:Histones; D029701:Saccharomyces cerevisiae Proteins; D035181:TATA-Box Binding Protein; D014157:Transcription Factors; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D012319:RNA Polymerase II