Multifocal electroretinogram with a multiflash stimulation technique in open-angle glaucoma.
OBJECTIVE
To analyze a multiflash multifocal electroretinogram in 20 patients with open-angle glaucoma (OAG).


METHODS
The stimulation sequence consisted of a binary m-sequence (L(max) 200 cd/m(2), L(min) <1 cd/m(2)). Each m-sequence stimulus was followed by three global flashes (luminance: 400 cd/m(2)) at an interval of 26 ms.


RESULTS
The presence of a response to the three global flashes indicated an adaptive effect of the response to the preceding m-sequence stimulus. In the nasal retinal response average the relative amplitude contribution of the response to the second global flash in relation to the other two global flash responses was outside the range of normal (10th-90th percentile) in 10 of 20 OAG patients.


CONCLUSIONS
The changes in the relative contribution of the response to the second global flash seem indicative of impaired adaptive effects presumably due to inner retinal damage.
Palmowski
A M
AM
Universitätsaugenklinik, Homburg, Germany. auapal@med-rz.uni-sb.de
Allgayer
R
R
Heinemann-Vernaleken
B
B
Ruprecht
K W
KW
D000328:Adult; D004596:Electroretinography / Q000379:methods*; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D010775:Photic Stimulation; D012160:Retina / Q000473:pathology*