Redox regulation of protein tyrosine phosphatases by hydrogen peroxide: detecting sulfenic acid intermediates and examining reversible inactivation.
Denu
John M
JM
Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97201, USA.
Tanner
Kirk G
KG
D009327:4-Chloro-7-nitrobenzofurazan; D020134:Catalytic Domain; D002460:Cell Line; D003545:Cysteine / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008954:Models, Biological; D010084:Oxidation-Reduction; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction; D013434:Sulfenic Acids / Q000737:chemistry
D004791:Enzyme Inhibitors; D013434:Sulfenic Acids; D004815:Epidermal Growth Factor; D006861:Hydrogen Peroxide; D017027:Protein Tyrosine Phosphatases; D009327:4-Chloro-7-nitrobenzofurazan; D005978:Glutathione; D003545:Cysteine