title: Intracranial aneurysm and vasculopathy after surgery and radiation therapy for craniopharyngioma: case report.
abstract: OBJECTIVE
  This case report illustrates the possible occurrence of intracranial aneurysms after surgery and radiation-induced vasculopathy.
  
  
  METHODS
  An internal carotid bifurcation aneurysm was diagnosed in a 19-year-old woman in a routine follow-up examination by magnetic resonance imaging 5 years after subtotal removal of a giant cystic craniopharyngioma treated by postoperative external radiotherapy. The presence of the aneurysm was confirmed by angiography.
  
  
  METHODS
  It was decided to treat the aneurysm by embolization with Guglielmi detachable coiling. However, at the beginning of the procedure, a few weeks after the diagnosis, a dramatic reduction in the carotid artery blood flow was observed, along with signs of thrombosis inside the aneurysm. In light of these findings, the procedure was aborted. Four months later, another angiographic examination confirmed the exclusion of the aneurysm and compensatory flow through the external carotid artery.
  
  
  CONCLUSIONS
  During the assessment of patients who have undergone postoperative radiotherapy, the potential for the development of aneurysms and radiation-induced vasculopathy exists and should be kept in mind. Considering the potential for spontaneous thrombosis of these aneurysms, cautious judgment is recommended before making a decision to treat them.
authors.affiliation: Department of Neurosurgery, Hospital S. Joao, Porto, Portugal. paulompereira@netc.pt
authors.forename: Paulo
authors.initials: P
authors.lastname: Pereira
authors.forename: Antonio
authors.initials: A
authors.lastname: Cerejo
authors.forename: Joaquim
authors.initials: J
authors.lastname: Cruz
authors.forename: Rui
authors.initials: R
authors.lastname: Vaz
mesh_terms: D000293:Adolescent; D015901:Angiography, Digital Subtraction; D002340:Carotid Artery Diseases / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D003397:Craniopharyngioma / Q000532:radiotherapy* / Q000601:surgery*; D004621:Embolization, Therapeutic / Q000009:adverse effects; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D011832:Radiation Injuries / Q000150:complications*; D013927:Thrombosis / Q000209:etiology