Protein dynamics in the nuclear compartment.
The classic view of a transcriptional initiation complex is that of an assembly of factors with many protein-protein contacts, leading to a multi-component complex whose existence is a result of the stabilizing influence of the many intermolecular interactions. Recent findings from protein mobility experiments in living cells indicate that many kinds of nuclear factors move rapidly and exchange quickly with multiple targets. Two countervailing views of factor/regulatory site interactions emerge from the current literature.
Hager
Gordon L
GL
Laboratory of Receptor Biology and Gene Expression, Building 41, B602, 41 Library Drive, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-5055, USA. hagerg@exchange.nih.gov
Elbi
Cem
C
Becker
Matthias
M
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism / Q000502:physiology*; D002843:Chromatin / Q000378:metabolism / Q000502:physiology; D049452:Green Fluorescent Proteins; D006801:Humans; D008164:Luminescent Proteins; D046911:Macromolecular Substances; D009687:Nuclear Proteins / Q000378:metabolism / Q000502:physiology*; D011401:Promoter Regions, Genetic / Q000502:physiology; D014158:Transcription, Genetic
D002843:Chromatin; D008164:Luminescent Proteins; D046911:Macromolecular Substances; D009687:Nuclear Proteins; D049452:Green Fluorescent Proteins