Hepatic blood flow measurements with arterial and portal blood flow mapping in the human liver by means of xenon CT.
OBJECTIVE
The purpose of this work was to quantify arterial and portal blood flows in the human liver and to create blood flow maps by means of xenon CT.


METHODS
Mathematical procedures were developed based on a simplified model having two tissue components: liver tissue and portal organ tissue. Xe-CT studies were performed on 10 healthy volunteers (ages 33.4 +/- 9.8 years), a patient with hepatocellular carcinoma (HCC), and a liver transplant recipient.


RESULTS
Arterial and portal blood flows for the healthy subjects were 36.7 +/- 5.2 and 65.2 +/- 22.0 ml/100 ml/min. In the HCC patient, arterial blood flow was shown to be dominant in the tumoral area. From the results of the liver recipient, it was demonstrated that obtaining lambda values is important for proper evaluation of blood flows.


CONCLUSIONS
Xe-CT can provide substantial information on hepatic blood flow quantitatively and visually with separation of arterial and portal components.
Sase
Shigeru
S
Anzai Medical Co, Ltd, Tokyo, Japan. sase@anzai-med.co.jp
Monden
Morito
M
Oka
Hiroshi
H
Dono
Keizo
K
Fukuta
Tatsuya
T
Shibata
Iekedo
I
D000328:Adult; D005260:Female; D006801:Humans; D008099:Liver / Q000098:blood supply*; D008297:Male; D008962:Models, Theoretical; D012039:Regional Blood Flow; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014978:Xenon
D014978:Xenon