Pectenotoxin-2 synthetic studies. 1. Alkoxide precoordination to [Rh(NBD)(DIPHOS-4)]BF(4) allows directed hydrogenation of a 2,3-dihydrofuran-3-ol without competing furan production.
[reaction: see text] The alkoxide-directed hydrogenation shown is reported as a key step in a concise synthesis of a fully functionalized precursor to the C29-C40 F/G sector of pectenotoxin-2.
Paquette
Leo A
LA
Evans Chemical Laboratories, The Ohio State University, Columbus, Ohio 43210, USA. paquette.1@osu.edu
Peng
Xiaowen
X
Bondar
Dmitriy
D
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D010087:Oxides / Q000737:chemistry*; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D000095702:Polyether Toxins
D000970:Antineoplastic Agents; D005663:Furans; D006859:Hydrogen; D018942:Macrolides; D010087:Oxides; D011714:Pyrans; C098380:pectenotoxin 2; D000095702:Polyether Toxins