Antioxidant activity of synthetic cytokinin analogues: 6-alkynyl- and 6-alkenylpurines as novel 15-Lipoxygenase inhibitors.
Synthetic cytokinin analogues as well as the well known CKs 6-benzylaminopurine (BAP), kinetin and trans-zeatin were examined for antioxidant activity. The compounds were tested as potential diphenylpicrylhydrazyl (DPPH) scavengers and as inhibitors of 15-lipoxygenase (15-LO). The natural plant hormones were essentially inactive in both assays, but several synthetic analogues have a profound inhibiting effect on 15-lipoxygenase from soybeans. The same compounds were only weak DPPH scavengers and they may therefore be regarded as so-called non antioxidant inhibitors of 15-LO.
Bråthe
Anders
A
Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N-0315, Oslo, Norway.
Andresen
Geir
G
Gundersen
Lise Lotte
LL
Malterud
Karl E
KE
Rise
Frode
F
D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003583:Cytokinins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013025:Glycine max / Q000201:enzymology; D013329:Structure-Activity Relationship
D000975:Antioxidants; D003583:Cytokinins; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D016859:Lipoxygenase Inhibitors; D011687:Purines