Plasma adenosine concentration increases during exercise: a possible contributing factor in exercise-induced bronchoconstriction in asthma.
We investigated whether the level of plasma adenosine (ADO) changed during exercise and whether this could be related to exercise-induced bronchoconstriction. Baseline levels of ADO did not differ, but exercise resulted in higher ADO in patients with asthma than in healthy subjects (86 +/- 35 vs 59 +/- 16 nmol/L; P <.001). In patients with asthma, the increase in ADO was related to decreases in FEV(1) (r (2) = 0.475; P <.05) and SaO(2) (r (2) = 0.693; P <.05). These data suggest that adenosine might be involved in the development of exercise-induced bronchoconstriction.
Vizi
Eva
E
Department of Pathophysiology, National Korányi Institute for Tuberculosis and Pulmonology, Budapest, Hungary.
Huszár
Eva
E
Csoma
Zsuzsa
Z
Böszörményi-Nagy
György
G
Barát
Erzsébet
E
Horváth
Ildikó
I
Herjavecz
Irén
I
Kollai
Márk
M
D000241:Adenosine / Q000097:blood*; D000293:Adolescent; D000328:Adult; D001250:Asthma, Exercise-Induced / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D016084:Bronchoconstriction; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D005082:Physical Exertion
D000241:Adenosine