title: A pilot study to investigate any relationship between sustained maximal inspiratory pressure and extubation outcome.
abstract: OBJECTIVE
  To establish whether any relationship exists between extubation outcome and sustained maximal inspiratory pressures (SMIP).
  
  
  METHODS
  Prospective clinical study in the 7-bed general intensive care unit of a university hospital.
  
  
  METHODS
  Twenty-seven intubated adults who were deemed ready for extubation were enrolled.
  
  
  METHODS
  Standard respiratory parameters and inspiratory muscle function data (ie, SMIP and peak maximal inspiratory pressures [MIP]) were recorded before extubation.
  
  
  RESULTS
  SMIP was found to be significantly greater in those who were successfully extubated than in those who underwent a failed extubation (P <.01). Receiver operating characteristic curves for SMIP data indicated that a cutoff point of 57.5 pressure time units would give a sensitivity and specificity of 1.0 for extubation outcome prediction. Peak MIP was also significantly greater in those successfully extubated (P =.04); a cutoff point of 17.5 cm H(2)O gave a sensitivity of 1.0 and a specificity of 0.5.
  
  
  CONCLUSIONS
  In this study, peak MIP was not specific enough to be clinically useful as a predictor of extubation outcome. SMIP was associated with extubation outcome with equally high sensitivity and specificity and may therefore have a role in outcome prediction.
authors.affiliation: School of Health Professions and Rehabilitation Sciences, University of Southampton, Highfield, Southampton SO17 1BJ, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Bruton
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016638:Critical Illness; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007320:Inspiratory Capacity; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012121:Respiration, Artificial; D012129:Respiratory Function Tests; D012132:Respiratory Muscles / Q000502:physiology*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013997:Time Factors; D015300:Ventilator Weaning