[Polymorphism of glutathione S-transferases M1 and T1 in several populations of Russia].
Frequencies of the wild-type and null genotypes of the GSTM1 and GSTT1 genes were established in healthy donors from several Russian populations (ethnic Russians from the towns of Oshevensk and Kholmogory, Arkhangel'sk oblast; ethnic Khants; ethnic Kalmyks; and ethnic Buryats) in order to identify the ethnic group with the maximal frequency of the null genotype. The highest frequency of individuals with the null genotype of both genes was observed in the Kalmyk and Buryat populations. The results may be used to study the effect of climatic and ecological conditions on multifactorial disease incidence in populations.
Popova
S N
SN
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182 Russia.
Slominskiĭ
P A
PA
Galushkin
S N
SN
Spitsyn
V A
VA
Guseva
I A
IA
Bebiakova
N A
NA
Limborskaia
S A
SA
D005828:Genetics, Population; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D012426:Russia / Q000208:ethnology; D012800:Siberia / Q000208:ethnology
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1