Treatment of experimental rabbit liver tumours by selectively targeted hyperthermia.
Experimental rabbit liver tumours were preferentially heated to therapeutic temperatures without compromising the surrounding normal hepatic parenchyma. This was achieved by the use of hepatic arterially infused ferromagnetic microspheres that heat as a result of magnetic hysteresis loss when exposed to an alternating magnetic field. Treatment sessions involving a single 20-min exposure to the alternating field resulted in total suppression of tumour growth at 14 days compared to controls, in which tumour sizes increased dramatically over the same period. Histopathological examination of treated tumour sections showed total tumour destruction in some cases. Separate animal groups used to control for the effects of the embolized microspheres alone and for the effect of the applied magnetic field yielded similar tumour growth responses to a control group with no intervention whatsoever. The achievement of positive temperature differentials between tumour and normal liver and the consequent therapeutic responses encourages further development of this technology for the treatment of liver cancer in humans.
Jones
S K
SK
Sirtex Medical Limited, North Ryde, NSW, Australia. sjones@sirtex.com
Winter
J G
JG
Gray
B N
BN
D000818:Animals; D006979:Hyperthermia, Induced; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D008863:Microspheres; D011817:Rabbits