title: Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria.
abstract: Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.
authors.affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: Paul N
authors.initials: PN
authors.lastname: Newton
authors.forename: Michele
authors.initials: M
authors.lastname: van Vugt
authors.forename: Paktiya
authors.initials: P
authors.lastname: Teja-Isavadharm
authors.forename: Duangsuda
authors.initials: D
authors.lastname: Siriyanonda
authors.forename: Maneerat
authors.initials: M
authors.lastname: Rasameesoroj
authors.forename: Pramote
authors.initials: P
authors.lastname: Teerapong
authors.forename: Ronatrai
authors.initials: R
authors.lastname: Ruangveerayuth
authors.forename: Thra
authors.initials: T
authors.lastname: Slight
authors.forename: Francois
authors.initials: F
authors.lastname: Nosten
authors.forename: Yupin
authors.initials: Y
authors.lastname: Suputtamongkol
authors.forename: Sornchai
authors.initials: S
authors.lastname: Looareesuwan
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D037621:Artemisinins; D000077332:Artesunate; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006207:Half-Life; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012717:Sesquiterpenes / Q000097:blood / Q000493:pharmacokinetics*; D013056:Spectrophotometry, Ultraviolet; D014744:Vietnam
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; D000077332:Artesunate; C039060:artenimol