title: Low-dose propofol infusion for sedation during local anesthesia.
abstract: The safety and efficacy of lose-dose propofol for sedation were investigated on 90 consenting patients who had undergone surgical procedures with local anesthesia. After being premedicated with intravenous midazolam 0.05 mg.kg(-1), all patients were randomly divided into two groups and received intravenously either a loading dose of propofol 0.8 mg.kg(-1) followed by a continuous infusion of propofol 30 microg.kg(-1)min(-1) (propofol group) or an equivalent volume of saline (placebo group) during operation. Study groups were compared with respect to the level of sedation, hemodynamic variables, oxygen saturation, and the incidence of intraoperative side effects. In addition, the discharge time and the satisfaction of both patients and surgeons with this sedative technique were assessed. Propofol reduced patients' discomfort and lowered their arterial pressure and heart rate during the infiltration of local anesthetics. It also promoted an adequate level of sedation without clinically significant oxygen desaturation in the intraoperative period. Surgeons and patients in the propofol group showed a higher level of satisfaction than those in the placebo group. There was no significant difference between the two groups with regard to the incidence of adverse effects and the discharge time. In conclusion, it was found that the use of low-dose propofol infusion was a safe and effective sedative technique for local anesthesia.
authors.affiliation: Department of Anesthesiology, College of Medicine, Korea University Ansan Hospital, 516 Gogan-Dong, Ansan-City, Kyong gi-Do, 425-020 Republic of Korea.
authors.forename: Hee-Dong
authors.initials: HD
authors.lastname: Yoon
authors.forename: Eul-Sik
authors.initials: ES
authors.lastname: Yoon
authors.forename: Eun-Sang
authors.initials: ES
authors.lastname: Dhong
authors.forename: Seung-Ha
authors.initials: SH
authors.lastname: Park
authors.forename: Seung-Kyu
authors.initials: SK
authors.lastname: Han
authors.forename: Sang-Hwan
authors.initials: SH
authors.lastname: Koo
authors.forename: Woo-Kyung
authors.initials: WK
authors.lastname: Kim
mesh_terms: D000328:Adult; D000772:Anesthesia, Local; D016292:Procedural Sedation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008297:Male; D015742:Propofol / Q000008:administration & dosage*; D011446:Prospective Studies
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol