Systemic administration of 1R,4S-4-amino-cyclopent-2-ene-carboxylic acid, a reversible inhibitor of GABA transaminase, blocks expression of conditioned place preference to cocaine and nicotine in rats.
We examined the effect of 1R,4S-4-amino-cyclopent-2-ene-carboxylic acid (ACC), a reversible inhibitor of GABA transaminase, on the expression of conditioned place preference response to cocaine and nicotine in rats. Cocaine (20 mg/kg i.p.) and nicotine (0.4 mg/kg s.c.), but not vehicle or 300 mg/kg i.p. of ACC, produced a significant conditioned place preference response. Pretreatment of animals with 300 and 75 mg/kg i.p. of ACC significantly attenuated the expression of the cocaine- and nicotine-induced conditioned place preference responses, respectively. These results are the first to suggest that reversible inhibition of GABA transaminase may be useful in blocking cue-induced relapse to nicotine and cocaine.
Ashby
Charles R
CR
Department of Pharmaceutical Sciences, St. John's University, Jamaica, Queens, New York 11439, USA. Crashby@ix.netcom.com
Paul
Mousumi
M
Gardner
Eliot L
EL
Gerasimov
Madina R
MR
Dewey
Stephen L
SL
Lennon
Ian C
IC
Taylor
Stephen J C
SJ
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000818:Animals; D003042:Cocaine / Q000037:antagonists & inhibitors*; D003216:Conditioning, Operant / Q000187:drug effects*; D003517:Cyclopentanes / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D009538:Nicotine / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley
C454079:4-amino-cyclopent-2-ene-carboxylic acid; D003517:Cyclopentanes; D009538:Nicotine; D000612:4-Aminobutyrate Transaminase; D003042:Cocaine