title: The RNA polymerase II machinery: structure illuminates function.
abstract: Essential components of the eukaryotic transcription apparatus include RNA polymerase II, a common set of initiation factors, and a Mediator complex that transmits regulatory information to the enzyme. Insights into mechanisms of transcription have been gained by three-dimensional structures for many of these factors and their complexes, especially for yeast RNA polymerase II at atomic resolution.
authors.affiliation: Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Woychik
authors.forename: Michael
authors.initials: M
authors.lastname: Hampsey
mesh_terms: D000818:Animals; D005656:Fungal Proteins / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D008954:Models, Biological; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D021122:Protein Subunits; D012319:RNA Polymerase II / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D005656:Fungal Proteins; D046911:Macromolecular Substances; D021122:Protein Subunits; D014157:Transcription Factors; D012319:RNA Polymerase II