[Study of the possibility of hyperparathyroidism development in rats exposed to internal irradiation by iodine radioisotope].
The possibility of hyperparathyroidism development secondary to earlier internal irradiation with radioactive iodine was studied experimentally in Wistar rats. This report describes the parathyroid morphology and biochemical findings for animals irradiated with 131I at the doses of 4.5, 40, or 80 Gy. The interval between the radiation exposure of two-month-old rats and their examination for thyroid and parathyroid pathology was 14 months. Neither hypercalcemia nor hypophosphatemia was found. Moreover, the level of calcium in serum slightly decreased following 40 and 80 Gy irradiation. The increased incidence of parathyroid fibrosis and hypofunctional structure transformation were revealed.
Budagov
R S
RS
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, 249036 Russia. budagov@obninsk.com
Chureeva
L N
LN
Chibisova
O F
OF
Barbarykina
G S
GS
Petrov
V N
VN
Podgorodnichenko
V K
VK
Belorukova
N V
NV
D000818:Animals; D002118:Calcium / Q000097:blood; D005260:Female; D005355:Fibrosis / Q000473:pathology; D006961:Hyperparathyroidism / Q000097:blood / Q000209:etiology* / Q000473:pathology; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D010280:Parathyroid Glands / Q000473:pathology / Q000528:radiation effects; D011829:Radiation Dosage; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000473:pathology / Q000528:radiation effects; D013997:Time Factors
D007457:Iodine Radioisotopes; D002118:Calcium