title: Fine-needle aspiration cytology of pulmonary rheumatoid nodule: case report and review of the major cytologic features.
abstract: Patients with rheumatoid disease may develop extra-articular lesions, affecting viscera and soft tissues. Pulmonary rheumatoid nodules show morphologic features reminiscent of a necrotizing inflammation of rheumatoid synovitis and differ from subcutaneous rheumatoid nodules only by their location, extension, and size. Although cytologic studies on pleural effusions in rheumatoid disease have long been performed, there are no more than three reports concerning the fine-needle aspiration (FNA) diagnosis of pulmonary rheumatoid nodules. The authors report on a case of a 62-yr-old woman with rheumatoid disease in whom a FNA diagnosis of pulmonary rheumatoid nodule was successfully performed. The authors highlight the main cytologic features of the entity and emphasise the high index of clinical and pathologic suspicions needed to be able to diagnose this lesion.
authors.affiliation: Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Rua Roberto Frias, S/N 4200 Porto, Portugal.
authors.forename: Jorge Sergio Reis
authors.initials: JS
authors.lastname: Filho
authors.forename: Maria Fernanda
authors.initials: MF
authors.lastname: Soares
authors.forename: Raquel
authors.initials: R
authors.lastname: Wal
authors.forename: Romy Beatriz
authors.initials: RB
authors.lastname: Christmann
authors.forename: Christian Bark
authors.initials: CB
authors.lastname: Liu
authors.forename: Fernando C
authors.initials: FC
authors.lastname: Schmitt
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications / Q000473:pathology; D001707:Biopsy, Needle; D005260:Female; D006099:Granuloma / Q000209:etiology / Q000473:pathology; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D008875:Middle Aged; D012218:Rheumatoid Nodule / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed