2-Diazoindoles: building blocks for the synthesis of antineoplastic agents.
2-Diazoindoles were prepared by diazotization of the corresponding 2-aminoindoles followed by neutralisation. 2-Diazoindoles were utilised for the synthesis of 2-triazenoindoles, indolo[2,1-d][1,2,3,5]tetrazines and indolo[2,1-c][1,2,4]triazines. Most of these compounds exhibited in vitro antiproliferative activity.
Barraja
Paola
P
Dipartimento Farmacochimico, Tossicologico e Biologico dell'Università, Palermo, Italy.
Diana
Patrizia
P
Lauria
Antonino
A
Almerico
Anna Maria
AM
Dattolo
Gaetano
G
Cirrincione
Girolamo
G
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D004563:Electrochemistry; D007211:Indoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012997:Solvents; D013329:Structure-Activity Relationship; D013696:Temperature
D000970:Antineoplastic Agents; D007211:Indoles; D012997:Solvents