Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections.
To examine the role of T cell receptor (TCR) in gammadelta T cells in adaptive immunity, a macaque model was used to follow Vgamma2Vdelta2+ T cell responses to mycobacterial infections. These phosphoantigen-specific gammadelta T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vgamma2Vdelta2+ T cells were also seen during Mycobacterium tuberculosis infection of naive and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vgamma2Vdelta2+ T cells may contribute to adaptive immunity to mycobacterial infections.
Shen
Yun
Y
Tuberculosis Research Unit, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Zhou
Dejiang
D
Qiu
Liyou
L
Lai
Xioamin
X
Simon
Meredith
M
Shen
Ling
L
Kou
Zhongchen
Z
Wang
Qifan
Q
Jiang
Liming
L
Estep
Jim
J
Hunt
Robert
R
Clagett
Michelle
M
Sehgal
Prabhat K
PK
Li
Yunyaun
Y
Zeng
Xuejun
X
Morita
Craig T
CT
Brenner
Michael B
MB
Letvin
Norman L
NL
Chen
Zheng W
ZW
D000818:Animals; D007113:Immunity, Innate / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D008251:Macaca / Q000276:immunology* / Q000382:microbiology*; D009163:Mycobacterium bovis / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology
D016692:Receptors, Antigen, T-Cell, gamma-delta