Toward rational design of species-specific inhibitors of Pneumocystis carinii thymidylate synthase and Toxoplasma gondii dihydrofolate reductase-thymidylate synthase.
Peaslee
K A
KA
Department of Chemistry, Dartmouth College, Burke Laboratories, Hanover, NH 03755, USA.
Anderson
A C
AC
D000818:Animals; D003460:Crystallization; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008961:Models, Structural; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D011010:Pneumocystis / Q000187:drug effects / Q000201:enzymology*; D013045:Species Specificity; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry / Q000378:metabolism; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D014122:Toxoplasma / Q000187:drug effects / Q000201:enzymology*
D004791:Enzyme Inhibitors; D009097:Multienzyme Complexes; C056930:thymidylate synthase-dihydrofolate reductase; D013762:Tetrahydrofolate Dehydrogenase; D013940:Thymidylate Synthase