Synthesis of 188 Re-labelled long chain alkyl diaminedithiol for therapy of liver cancer.
Radioisotope-labelled lipiodol has been used in the therapy of liver cancer. Recently a lipiodol solution of 188Re-labelled diaminedithiol (DD) has been reported to show a high uptake in the liver cancer. We synthesized long-chain alkyl DD derivatives to improve their uptake and retention in tissue. As the length of the alkyl chain increased, tissue uptake and retention also increased due to hydrophobic interaction with lipiodol. Among the synthesized compounds, the lipiodol solution of 188Re-HDD, the DD derivative with the longest side chain (C16), is a promising agent for therapy of liver cancer.
Lee
Y-S
YS
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.
Jeong
J M
JM
Kim
Y J
YJ
Chung
J W
JW
Park
J H
JH
Suh
Y-G
YG
Lee
D S
DS
Chung
J-K
JK
Lee
M C
MC
D000818:Animals; D006801:Humans; D007459:Iodized Oil / Q000493:pharmacokinetics*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000532:radiotherapy; D008168:Lung / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D014018:Tissue Distribution
D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C464431:rhenium diaminedithiol; D007459:Iodized Oil