title: [Efficiency of antiarrhythmic drugs of class 1C and isoptin in paroxysmal supraventricular tachycardia].
abstract: Cross-over trial studied comparative effectiveness and tolerance of allapinine, rhythmonorm and isoptine in patients with paroxysmal supraventricular tachycardia (PSVT). Treatment effects did not differ much. Analysis of the preventive efficiency of the above drugs with reference to PSVT form has demonstrated that in paroxysmal atrioventricular reciprocal tachycardia the highest activity was shown by isoptine and rhythmonorm, in paroxysmal orthodromic reciprocal tachycardia--by rhythmonorm and allapinin. In long-term therapy, a preventive effects of allapinin, rhythmonorm and isoptine achieved at short-term course therapy persisted in 90.9, 95.6 and 81.5% patients, respectively. All the above drugs cause moderate inhibition of atrioventricular and intraventricular conduction. Isoptin had the best tolerance.
authors.forename: K M
authors.initials: KM
authors.lastname: Koshumbaeva
authors.forename: M T
authors.initials: MT
authors.lastname: Tulenov
authors.forename: I N
authors.initials: IN
authors.lastname: Belokopit
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013614:Tachycardia, Paroxysmal / Q000150:complications / Q000188:drug therapy*; D013617:Tachycardia, Supraventricular / Q000150:complications / Q000188:drug therapy*; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D000889:Anti-Arrhythmia Agents; C051402:allapinin; D014700:Verapamil; D000157:Aconitine