title: Metabolic cardiovascular syndrome in obese prepubertal children: the role of high fasting insulin levels.
abstract: The aim of this study was to detect the presence and degree of impairment of cardiovascular disease (CVD) risk factors, grouped as metabolic cardiovascular syndrome (MCS), in obese prepubertal children. We also assessed the influence of high fasting insulin levels in this pathological status. A cross-sectional study was performed on obese children based on fasting blood samples. Subjects were 61 obese children (aged 6 to 9 years) and an equal number of non-obese children paired by age and sex. The obese children presented the following characteristics in comparison to the non-obese group: significantly high levels of insulin (8.2 +/- 0.52 v 6.12 +/- 0.34 microU/mL), triglycerides (TG) (0.79 +/- 0.04 v 0.60 +/- 0.02 mmol/L), uric acid (0.24 +/- 0.005 v 0.21 +/- 0.004 mmol/L), systolic (SBP) (94.59 +/- 1.06 v 88.85 +/- 1.2 mm Hg) and diastolic (56.49 +/- 1.07 v 52.21 +/- 1.06 mm Hg) blood pressure (DBP), and low levels of high-density lipoprotein cholesterol (HDL-C) (1.30 +/- 0.04 v 1.46 +/- 0.03 mmol/L), and nonesterified fatty acids (0.407 +/- 0.02 v 0.505 +/- 0.02 mmol/L). The hyperinsulinemic obese children showed the same types of differences when compared with the normoinsulinemic group. In the obese group, having adjusted for age, waist/hip ratio (WHR), body mass index (BMI), and sex hormone-binding globulin (SHBG), insulin was an independent prediction factor for triglycerides (P =.0004), apolipoprotein A-I (Apo-AI) (P =.005), and alanine aminotransferase (ALT) (P =.029). BMI was an independent prediction factor for HDL-C (P =.001) and triglycerides (P =.027). However, insulin was an independent prediction factor in the control group for triglycerides (P =.0002) and SBP (P =.012), just as BMI was for HDL-C (P =.011) and uric acid (P =.041). We conclude that the cluster of CVD risk factors associated with MCS and intra-abdominal fat is present in obese prepubertal children. This situation seems to depend, to a large extent, on the insulin basal level. The apparent association between BMI and MCS is due to the correlation between BMI and insulin, and to the fact that insulin associates with MCS. Within the obese group, hyperinsulinemic children present the greatest impairment in the parameters considered to be constituents of MCS.
authors.affiliation: Department of Clinical Laboratory, Valle de los Pedroches Hospital, Pozoblanco, Córdoba, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Valle
authors.forename: Félix
authors.initials: F
authors.lastname: Gascón
authors.forename: Rosario
authors.initials: R
authors.lastname: Martos
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Ruz
authors.forename: Francisco
authors.initials: F
authors.lastname: Bermudo
authors.forename: Rosario
authors.initials: R
authors.lastname: Morales
authors.forename: Ramón
authors.initials: R
authors.lastname: Cañete
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001053:Apolipoproteins / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000235:genetics*; D002648:Child; D005215:Fasting / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008074:Lipoproteins / Q000097:blood; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D011627:Puberty; D012016:Reference Values; D012044:Regression Analysis; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013577:Syndrome; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D001053:Apolipoproteins; D007328:Insulin; D008074:Lipoproteins; D012738:Sex Hormone-Binding Globulin; D014280:Triglycerides; D014527:Uric Acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase