title: Effects of depression and Parkinson's disease on cognitive functioning.
abstract: This study compared the performance of Parkinson's disease (PD) patients with and without depression, patients with depression alone, and normal control subjects on a cognitive screening instrument, the Mattis Dementia Rating Scale (DRS) to evaluate the influences of depression and Parkinson's disease on cognition. PD affects overall level of cognitive functioning and, to a lesser extent, DRS Initiation/Perseveration, Construction, and Attention. Diminished memory was primarily related to depression. Treatment of depression may ameliorate aspects of cognitive dysfunction in the PD patient with depression.
authors.affiliation: Department of Psychology, Xavier University, Cincinnati, Ohio 45207-6511, USA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Norman
authors.forename: Alexander I
authors.initials: AI
authors.lastname: Tröster
authors.forename: Julie A
authors.initials: JA
authors.lastname: Fields
authors.forename: Rebecca
authors.initials: R
authors.lastname: Brooks
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001288:Attention / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D003704:Dementia / Q000523:psychology; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000188:drug therapy / Q000523:psychology*; D011569:Psychiatric Status Rating Scales
chemical_list: D000928:Antidepressive Agents; D000978:Antiparkinson Agents