title: Atrial natriuretic factor as marker of myocardial compromise in Chagas' disease.
abstract: This study investigated the evolution of plasma atrial natriuretic factor (ANF) in patients in different stages of Chagas' disease and analyzed its usefulness as prognostic factor of the development of myocardial compromise in asymptomatic chagasic patients. Chagas' disease, a determinant of heart failure, is caused by the parasite Trypanosoma cruzi. A total of 21 chagasic patients were studied: 9 in the asymptomatic stage, 6 with conduction defects (CD), and 6 with chronic heart failure (CHF); and 31 controls: 16 healthy, 6 with CD, and 9 with CHF. Plasma ANF radioimmunoassay (RIA) and complementary studies were performed twice for each patient, with an interval period of 12 months. First sample: chagasic patients showed higher ANF levels in the CHF group than in CD and asymptomatic subjects; second sample: the peptide levels were higher in CHF patients than in the asymptomatic group. In non-chagasic CHF patients, ANF levels were higher than in CD patients and controls in both samples. ANF levels were not able to differentiate chagasic asymptomatic and CD patients from healthy subjects and CD controls; meanwhile, chagasic CHF patients showed lower plasma ANF than their controls. Furthermore, ANF is a sensitive marker capable of detecting gradual impairments in cardiac function in all patients studied.
authors.affiliation: Cátedra de Biología Celular e Histología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, (1113), Buenos Aires, Argentina.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Puyó
authors.forename: Jorge
authors.initials: J
authors.lastname: Scaglione
authors.forename: Sergio
authors.initials: S
authors.lastname: Auger
authors.forename: Susana
authors.initials: S
authors.lastname: Cavallero
authors.forename: Adriana S
authors.initials: AS
authors.lastname: Donoso
authors.forename: Horacio A
authors.initials: HA
authors.lastname: Dupuy
authors.forename: Belisario E
authors.initials: BE
authors.lastname: Fernández
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D015415:Biomarkers; D002598:Chagas Cardiomyopathy / Q000097:blood / Q000503:physiopathology*; D014355:Chagas Disease / Q000097:blood / Q000503:physiopathology; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014349:Trypanosoma cruzi
chemical_list: D015415:Biomarkers; D009320:Atrial Natriuretic Factor