Association mapping: where we've been, where we're going.
This paper provides a review of recent work in the area of marker-phenotype association studies, specifically as used for localizing--or mapping--genes affecting a trait of interest. We describe the basis of association mapping and discuss a number of the commonly used techniques. We have also included references to various papers that have evaluated the use of these methods.
Nielsen
D M
DM
North Carolina State University, Program in Statistical Genetics, Department of Statistics, Raleigh, NC 27695-7566, USA. dahlia@statgen.ncsu.edu
Zaykin
D
D
D000704:Analysis of Variance; D016022:Case-Control Studies; D002874:Chromosome Mapping; D005192:Family Health; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D025202:Molecular Diagnostic Techniques; D010641:Phenotype; D019655:Quantitative Trait, Heritable
D005819:Genetic Markers