title: Effects of acoustic overstimulation on cochlear evoked potentials.
abstract: Guinea pigs were exposed to 2 kHz pure-tone or octave-band pass noise at an intensity of 100 dBSPL for 30 min. The effects of sound exposure on cochlear microphonics (CM) and compound action potential (AP) were studied using a test condition devised to complete the measurement of the sensitivity of both potentials for the frequency from 1 to 7 kHz within several minutes. The loss of CM sensitivity was limited to around 5 dB for all test frequencies in animals exposed either to pure-tone or band noise. In contrast, the loss of AP in both exposure conditions was significantly greater than that of the CM, and the magnitude of the AP losses reflected the frequency characteristics of the exposure sounds. From these observations, the AP is considered to be a more sufficient index than the CM in studying the effects of acoustic overstimulation.
authors.affiliation: Department of Otorhinolaryngology, University of Occupational and Environmental Health, School of Medicine, Yahata-nishiku, Kitakyushu 807, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Aoyagi
authors.forename: K
authors.initials: K
authors.lastname: Makishima
mesh_terms: D000818:Animals; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000502:physiology*; D015834:Cochlear Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006168:Guinea Pigs; D009622:Noise / Q000009:adverse effects*