title: Impaired olfaction predicts cognitive decline in nondemented older adults.
abstract: In 1992, the twelve-item Brief Smell Identification Test((R)) and, in 1992 and 1996, a variety of measures of verbal learning and memory, executive control, and global function were administered to a total of 359 individuals (286 men and 73 women; mean age in 1992 74.3 years). Individuals with a history of stroke or impaired cognition at baseline were excluded from analyses. Impaired olfactory function (present or absent) was related to a greater 4.5-year decline on several indices of verbal memory, but not to a decline on measures of executive control or of global functioning after adjustment for baseline cognitive performance, age, education, gender, and history of smell difficulties. Olfactory loss remained associated with a decline in components of verbal memory, independently of the apolipoprotein E epsilon4 status. The predictive utility of impaired smell identification in older adults appears to be specific to a decline in components of verbal memory.
authors.affiliation: Center for Health Sciences, SRI International, Menlo Park, Calif., 94025, USA. gswan@unix.sri.com
authors.forename: Gary E
authors.initials: GE
authors.lastname: Swan
authors.forename: Dorit
authors.initials: D
authors.lastname: Carmelli
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000175:diagnosis* / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D000857:Olfaction Disorders / Q000150:complications / Q000473:pathology*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity