[Evaluation of glucose, insulin, C-peptide uric acid serum levels in patients with psoriasis].
The aim of our study was to estimate the serum levels of glucose, insulin, C-peptide and uric acid in patients with psoriasis before and after treatment. The study included 12 males with active form of psoriasis and 15 control subjects carefully matched to the psoriatic patients for age and BMI. All measured parameters were in patients with psoriasis significantly increased and dependent on the BMI. Compared with pretreatment values of glucose and uric acid were significantly lower during therapy. The increase in the mean C-peptide and insulin levels after psoriasis therapy was constant and independent from clinical stage of disease. The results of the present study have provided evidence for the importance of impaired glucose and purine metabolism in patients with psoriasis in the increase risk of development of diabetes mellitus and hypertension.
Grzybowski
G
G
Oddział Dermatologiczny Szpitala im. J. Strusia w Poznaniu.
Fafara
I
I
Zaba
R
R
Wierusz-Wysocka
B
B
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood*; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000150:complications / Q000628:therapy*; D012306:Risk; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood*
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D014527:Uric Acid