A fatal human intoxication with the herbicide allyl alcohol (2-propen-1-ol).
Oral ingestion of allyl alcohol by a 55-year-old man resulted in death within 100 min. At autopsy, bloody, reddish fluid was found in mouth, larynx, esophagus, and trachea. The mucous membranes of the trachea, stomach, and duodenum were congested and inflamed. The stomach contained a pungent green-black fluid, and all internal organs exhibited a strong pungent odor. Toxicological analysis of blood identified allyl alcohol using solid-phase microextraction and gas chromatography-mass spectrometry. Quantitative determination of allyl alcohol and its toxic metabolite, acrolein, was performed using headspace gas chromatography with flame-ionization detection. Total amounts of allyl alcohol in gastric content, bile, and urine were 3.6 g, 15 mg, and 0.5 mg, respectively. The concentration in blood was 309 mg/L. Acrolein was not detected in gastric contents and only in small amounts in bile and urine. The concentration of acrolein in blood was 7.2 mg/L. Death was attributed to acrolein-induced acute cardiotoxicity, similar to that previously documented in animal experiments.
Toennes
Stefan W
SW
Institute of Forensic Toxicology, University of Frankfurt, Frankfurt/Main, Germany. toennes@em.uni-frankfurt.de
Schmidt
Karl
K
Fandiño
Anabel S
AS
Kauert
Gerold F
GF
D000171:Acrolein / Q000032:analysis; D001344:Autopsy; D001826:Body Fluids / Q000737:chemistry; D002849:Chromatography, Gas; D005766:Gastrointestinal Contents / Q000737:chemistry; D006540:Herbicides / Q000032:analysis / Q000493:pharmacokinetics / Q000506:poisoning*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011041:Poisoning / Q000378:metabolism / Q000473:pathology; D020005:Propanols / Q000032:analysis / Q000493:pharmacokinetics / Q000506:poisoning*; D014018:Tissue Distribution
D006540:Herbicides; D020005:Propanols; C006463:allyl alcohol; D000171:Acrolein