Evaluation of vaccines for atrophic rhinitis--a comparison of three challenge models.
We compared three challenge models for the assessment of atrophic rhinitis (AR) vaccines: combined infection with Bordetella bronchiseptica (Bb) and Pasteurella multocida (Pm); application of acetic acid (AA) to the nasal mucosa followed by Pm infection; and Bb infection alone. Two vaccines were tested using standardized criteria, notably nasal lesion scores. The vaccines provided different levels of protection in the Bb and the AA/Pm challenges, but were similar in the combined (Bb/Pm) challenge. It is clear that the AA/Pm model shows the protective value of only the Pm component, whereas the single Bb challenge reflects the protective value merely of the Bb component of a combined vaccine. These results suggest that the best assessment of protection is provided if the two specific challenges are performed separately.
Magyar
T
T
Veterinary Medical Research Institute of the Hungarian Academy of Sciences, P.O. Box 18, H-1581 Budapest, Hungary. tibor@novell.vmri.hu
King
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VL
Kovács
F
F
D019342:Acetic Acid / Q000008:administration & dosage; D000281:Administration, Intranasal; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D001885:Bordetella Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary; D016950:Bordetella bronchiseptica / Q000276:immunology; D005260:Female; D010326:Pasteurella Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary; D016979:Pasteurella multocida / Q000276:immunology; D011247:Pregnancy; D012222:Rhinitis, Atrophic / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control*; D017778:Vaccines, Combined / Q000008:administration & dosage
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D017778:Vaccines, Combined; D019342:Acetic Acid