title: Epidermal dysplasia and Malassezia infection in two West Highland White Terrier siblings: an inherited skin disorder or reaction to severe Malassezia infection?
abstract: Two 9-month-old West Highland White Terrier siblings were referred to our clinic with pruritus, alopecia and lichenification. Cytological examination of Scotch tape strippings revealed Malassezia organisms and cocci. Skin biopsy specimens showed epidermal dysplasia. Treatment included bathing with a 2% miconazole/chlorhexidine-containing shampoo, orally administered ketoconazole (5 mg kg-1, every 12 h) and cloxacillin (25 mg kg-1 every 8 h). Six weeks later, the dermal infection had resolved and there was hair regrowth. However, the dogs were still moderately pruritic. Intradermal allergy testing was positive for house dust mites, storage mites and Malassezia. Immunotherapy was initiated, and treatment with ketoconazole and cloxacillin was stopped. Skin biopsies, which were performed in both dogs 4 months after the first presentation, revealed mild superficial perivascular dermatitis. The remaining mild facial pruritus was easily controlled with topical treatment. These two cases indicate that epidermal dysplasia might be an inflammatory or hypersensitivity reaction to the Malassezia infection or a result of excessive self-trauma, rather than a congenital keratinization disorder.
authors.affiliation: Clinic of Small Animal Internal Medicine, Department for Reproduction and Institute for Pathology of the University of Zurich, Switzerland. cnett@freesurf.ch
authors.forename: C S
authors.initials: CS
authors.lastname: Nett
authors.forename: I
authors.initials: I
authors.lastname: Reichler
authors.forename: P
authors.initials: P
authors.lastname: Grest
authors.forename: B
authors.initials: B
authors.lastname: Hauser
authors.forename: C E
authors.initials: CE
authors.lastname: Reusch
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D003881:Dermatomycoses / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005260:Female; D007428:Intradermal Tests / Q000662:veterinary; D008290:Malassezia / Q000302:isolation & purification*; D008297:Male