Soluble intercellular adhesion molecules in the serum of subjects exposed to dust at different workplaces--correlation to airway symptoms, lung function, tobacco and dust exposure.
Soluble intercellular adhesion molecule 1 (s-ICAM-1) was evaluated as biomarker indicating inflammatory processes in the airways of persons exposed to salt dust, ceramic dust and flour dust. ICAM values in the serum of these workers were related to airway symptoms, lung function (FEV1), inhalable dust dose and tobacco consumption. A weak relation was found to airway symptoms (cough and phlegm) and FEV1. Consistent elevated ICAM levels in smokers suggest, that ICAM indicates inflammatory processes following strong irritants such as tobacco smoke. In contrast to lung function analysis, serum ICAM does not support inflammatory changes by salt dust or ceramic dust.
Backé
Eva-Maria
EM
Federal Institute for Occupational Safety and Health, Nöldnerstrasse 40-42, D-10317 Berlin, Germany. Backé.Eva-Maria@baua.bund.de
Lotz
Gabriele
G
Tittelbach
Ulrike
U
Bolm-Audorff
Ulrich
U
Wallenstein
Gesa
G
Schneider
Wolfram Dietmar
WD
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002516:Ceramics; D003371:Cough / Q000209:etiology; D004391:Dust / Q000009:adverse effects*; D005433:Flour; D006801:Humans; D007249:Inflammation; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D016273:Occupational Exposure; D012129:Respiratory Function Tests; D012907:Smoking / Q000009:adverse effects; D012965:Sodium Chloride; D017132:Workplace
D015415:Biomarkers; D004391:Dust; D018799:Intercellular Adhesion Molecule-1; D012965:Sodium Chloride