Inhibition of in vitro leukocyte proliferation by morbilliviruses.
Immune suppression associated with morbillivirus infections may influence the mortality rate by allowing secondary bacterial infections that are lethal to the host to flourish. Using an in vitro proliferation assay, we have shown that all members of the genus Morbillivirus inhibit the proliferation of a human B-lymphoblast cell line (BJAB). Proliferation of freshly isolated, stimulated bovine and caprine peripheral blood lymphocytes is also inhibited by UV-inactivated rinderpest (RPV) and peste-des-petits ruminants viruses. As for measles virus, coexpression of both the fusion and the hemagglutinin proteins of RPV is necessary and sufficient to induce immune suppression in vitro.
Heaney
J
J
Institute for Animal Health, Pirbright, Surrey GU24 ONF, United Kingdom.
Barrett
T
T
Cosby
S L
SL
D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D006023:Glycoproteins / Q000494:pharmacology; D006041:Goats; D006389:Hemagglutinins, Viral; D006801:Humans; D007962:Leukocytes / Q000166:cytology / Q000821:virology*; D008214:Lymphocytes / Q000166:cytology / Q000821:virology; D008565:Membrane Proteins; D018103:Morbillivirus / Q000276:immunology* / Q000528:radiation effects; D011994:Recombinant Proteins / Q000494:pharmacology; D014466:Ultraviolet Rays; D014760:Viral Fusion Proteins / Q000494:pharmacology; D014764:Viral Proteins / Q000494:pharmacology
C079748:F protein, Rinderpest virus; D006023:Glycoproteins; D006389:Hemagglutinins, Viral; D008565:Membrane Proteins; D011994:Recombinant Proteins; D014760:Viral Fusion Proteins; D014764:Viral Proteins; C079749:hemagglutinin protein, Rinderpest virus