Novel miniaturized systems in high-throughput screening.
High-throughput screening (HTS) using high-density microplates is the primary method for the discovery of novel lead candidate molecules. However, new strategies that eschew 2D microplate technology, including technologies that enable mass screening of targets against large combinatorial libraries, have the potential to greatly increase throughput and decrease unit cost. This review presents an overview of state-of-the-art microplate-based HTS technology and includes a discussion of emerging miniaturized systems for HTS. We focus on new methods of encoding combinatorial libraries that promise throughputs of as many as 100,000 compounds per second.
Battersby
Bronwyn J
BJ
Centre for Nanotechnology and Biomaterials, Dept of Chemistry, The University of Queensland, St Lucia, Australia.
Trau
Matt
M
D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends*; D016208:Databases, Factual / Q000639:trends*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods* / Q000639:trends; D005544:Forecasting; D016247:Information Storage and Retrieval / Q000379:methods*; D007257:Information Theory; D008904:Miniaturization / Q000379:methods*