Cortactin is necessary for F-actin accumulation in pedestal structures induced by enteropathogenic Escherichia coli infection.
Cortactin and the translocated intimin receptor, Tir, interacted with each other in pedestal formation in HeLa cells infected with enteropathogenic Escherichia coli (EPEC). Cortactin is shown to be necessary for organizing actin pedestals in response to EPEC, based on the expression of green fluorescent protein-fused cortactin derivatives in HeLa cells.
Cantarelli
Vlademir V
VV
Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Takahashi
Akira
A
Yanagihara
Itaru
I
Akeda
Yukihiro
Y
Imura
Kinichi
K
Kodama
Toshio
T
Kono
Gengo
G
Sato
Yoshihisa
Y
Iida
Tetsuya
T
Honda
Takeshi
T
D000199:Actins / Q000378:metabolism*; D051356:Cortactin; D004926:Escherichia coli / Q000502:physiology*; D029968:Escherichia coli Proteins; D049452:Green Fluorescent Proteins; D006367:HeLa Cells; D006801:Humans; D008164:Luminescent Proteins / Q000378:metabolism; D008840:Microfilament Proteins / Q000737:chemistry / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology
D000199:Actins; C495868:CTTN protein, human; D051356:Cortactin; D029968:Escherichia coli Proteins; D008164:Luminescent Proteins; D008840:Microfilament Proteins; D011956:Receptors, Cell Surface; C109287:Tir protein, E coli; D049452:Green Fluorescent Proteins