Effects of isopropyl unoprostone, latanoprost, and prostaglandin E(2) on acute rise of aqueous flare in pigmented rabbits.
OBJECTIVE
To evaluate the effect of isopropyl unoprostone, latanoprost, and prostaglandin E(2) (PGE(2)) on aqueous flare elevation.


METHODS
Isopropyl unoprostone (0.12%) or latanoprost (0.005%) was topically instilled. Transcorneal diffusion of PGE(2), 25 microg/ml, using a glass cylinder, was achieved in pigmented rabbits. Aqueous flare was measured with a laser flare cell meter.


RESULTS
Topical instillation of isopropyl unoprostone induced aqueous flare elevation in rabbit eyes. Also, topical isopropyl unoprostone additionally induced aqueous flare elevation in eyes with transcorneal diffusion of PGE(2). Latanoprost did not induce flare elevation.


CONCLUSIONS
Isopropyl unoprostone induced aqueous flare elevation in rabbits, and latanoprost did not produce aqueous flare elevation.
Zhang
Xue-Yun
XY
Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan.
Hayasaka
Seiji
S
Hayasaka
Yoriko
Y
Yanagisawa
Shuichiro
S
Nagaki
Yasunori
Y
D000287:Administration, Topical; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001082:Aqueous Humor / Q000187:drug effects* / Q000378:metabolism; D018916:Blood-Aqueous Barrier; D015237:Dinoprost / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D015232:Dinoprostone / Q000008:administration & dosage*; D007429:Intraocular Pressure; D000077338:Latanoprost; D008297:Male; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*; D011817:Rabbits; D014606:Uveitis, Anterior / Q000139:chemically induced*
D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; C072630:isopropyl unoprostone; D000077338:Latanoprost; D015237:Dinoprost; D015232:Dinoprostone