title: Degradation of gel in tray whitening.
abstract: This article will address the breakdown or lowering of active bleaching agent concentration during use in the mouth. A greater than expected degradation occurs during the first 5 minutes followed by an exponential rate loss. Subjects have a large variation in degradation rates. After 2 and 6 hours there was 52% and 24% respectively, of the active agent present in a carbamide peroxide gel. The presence or absence of the pellicle did not affect the rate of degradation. The relationship of gel degradation to the whitening capability of a gel is yet to be determined.
authors.affiliation: Clinical Research Section, Indiana University, School of Dentistry, Indianapolis, Indiana, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Matis
mesh_terms: D001673:Biodegradation, Environmental; D003741:Dental Deposits; D003742:Dental Devices, Home Care; D044622:Dental Pellicle; D004305:Dose-Response Relationship, Drug; D005782:Gels / Q000493:pharmacokinetics; D006801:Humans; D006863:Hydrogen-Ion Concentration; D016877:Oxidants / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D010545:Peroxides / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D012463:Saliva / Q000737:chemistry / Q000378:metabolism; D014073:Tooth Bleaching / Q000295:instrumentation / Q000379:methods*
chemical_list: D005782:Gels; D016877:Oxidants; D010545:Peroxides