Asthma genetics.
Asthma is the most common chronic childhood disease in developed nations and is a complex disease that has high social and economic costs. Asthma and its associated intermediate phenotypes are under a substantial degree of genetic control. Identifying the genes underlying asthma offers a means of better understanding its pathogenesis, with the promise of improving preventive strategies, diagnostic tools, and therapies. A number of chromosomal regions containing genes influencing asthma and atopy have been identified consistently by different groups, and a role for several candidate genes has been established.
Cookson
William Osmond Charles
WO
Department of Human Genetics, University of Oxford, Oxford, UK. wocc@ox.ac.uk
D000818:Animals; D001249:Asthma / Q000235:genetics*; D002874:Chromosome Mapping; D005802:Genes, MHC Class II; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics; D007070:Immunoglobulin A / Q000235:genetics; D007378:Interleukins / Q000235:genetics; D011110:Polymorphism, Genetic; D017455:Receptors, IgE / Q000235:genetics
D007070:Immunoglobulin A; D007378:Interleukins; D017455:Receptors, IgE