Glycopeptide antibiotics and development of inhibitors to overcome vancomycin resistance.
This review outlines the history of vancomycin and other key glycopeptide antibiotics and the molecular basis of vancomycin resistance, and focuses on the development of synthetic inhibitors of vancomycin-resistant enzymes VanR, S, A, H and X to overcome resistance. The literature up to July 2001 is reviewed and 119 references are cited.
Gao
Yong
Y
Department of Chemistry and Biochemistry, Southern Illinois University at Carbondale, 62901-4409, USA. ygao@chem.siu.edu
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000378:metabolism; D016983:Enterococcus / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D006020:Glycopeptides; D006094:Gram-Positive Bacteria / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure; D011494:Protein Kinases / Q000378:metabolism; D046929:Serine-Type D-Ala-D-Ala Carboxypeptidase; D013290:Streptococcal Infections / Q000188:drug therapy*; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology; D014157:Transcription Factors / Q000378:metabolism; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D006020:Glycopeptides; C454080:LY266,400; C454081:LY266,408; D013844:Thiazoles; D014157:Transcription Factors; C073902:VanR protein, bacteria; C073901:VanS protein, Enterococcus; D011494:Protein Kinases; D046929:Serine-Type D-Ala-D-Ala Carboxypeptidase; C091956:VanX dipeptidase