Peroxynitrite activates K+-Cl- cotransport in human erythrocytes.
Peroxynitrite was found to induce the release of K+ via the Na+/Cl- cotransport system, as do other oxidants. Since peroxynitrite is formed in vivo, its presence could contribute to a pathological dehydration of red blood cells.
Grzelak
A
A
Department of Molecular Biophysics, University of Lódź, Poland. kbm@biol.uni.lodz.pl
Mazur
J
J
Bartosz
G
G
D002713:Chlorine / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D016623:Ion Pumps / Q000187:drug effects / Q000502:physiology; D017136:Ion Transport / Q000187:drug effects* / Q000502:physiology; D030421:Peroxynitrous Acid / Q000378:metabolism / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*
D016623:Ion Pumps; D030421:Peroxynitrous Acid; D002713:Chlorine; D011188:Potassium