The FHA domain.
The forkhead-associated (FHA) domain is a small protein module recently shown to recognize phosphothreonine epitopes on proteins. It is present in a diverse range of proteins in eukaryotic cells, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins, and metabolic enzymes. It is also found in a number of bacterial proteins. This suggests that FHA domain-mediated phospho-dependent assembly of protein complexes is an ancient and widespread regulatory mechanism.
Durocher
Daniel
D
Samuel Lumenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1 X5. durocher@mshri.on.ca
Jackson
Stephen P
SP
D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D004249:DNA Damage; D004260:DNA Repair; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D000939:Epitopes / Q000378:metabolism; D016547:Kinesins / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D010748:Phosphopeptides / Q000737:chemistry* / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000737:chemistry / Q000378:metabolism; D010769:Phosphothreonine / Q000378:metabolism; D010770:Phosphotransferases / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism
D001426:Bacterial Proteins; D004798:Enzymes; D000939:Epitopes; D010748:Phosphopeptides; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D010769:Phosphothreonine; D010770:Phosphotransferases; D010744:Phosphoric Monoester Hydrolases; D016547:Kinesins