title: Development and surgical implantation of a vision prosthesis model into the ovine eye.
abstract: OBJECTIVE
  A surgical technique was designed and tested to enable the implantation of an intraocular electrical retinal stimulator.
  
  
  METHODS
  An inoperative perspex and silicone model was constructed to closely resemble the anticipated properties of the proposed visual prosthesis. The animal model chosen for these experiments was the sheep, because the dimensions of its ocular anatomy are approximately 30% larger than the human's, being otherwise grossly similar. The surgical method involved transplanar port-hole lensectomy and vitrectomy, insertion of the model implant through a limbal incision, and fixation of the perspex subunit close to the location of the native crystalline lens, by way of trans-pars plana fixation sutures. Adequate pre-retinal positioning of the implant's silicone extension was obtained by way of its inherent elastic recoil.
  
  
  RESULTS
  The procedure was performed without macroscopic evidence of undue surgical trauma.
  
  
  CONCLUSIONS
  Although further long-term experiments are required to fully assess the surgical procedure and biocompatibility of the implant, intraoperative assessment and postmortem computed tomographic imaging of the globe has confirmed the successful intraocular positioning and fixation of the implant.
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia.
authors.forename: Yves A
authors.initials: YA
authors.lastname: Kerdraon
authors.forename: John A
authors.initials: JA
authors.lastname: Downie
authors.forename: Gregg J
authors.initials: GJ
authors.lastname: Suaning
authors.forename: Malcolm R
authors.initials: MR
authors.lastname: Capon
authors.forename: Minas T
authors.initials: MT
authors.lastname: Coroneo
authors.forename: Nigel H
authors.initials: NH
authors.lastname: Lovell
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001766:Blindness / Q000534:rehabilitation; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D007908:Lens, Crystalline / Q000601:surgery; D023421:Models, Animal; D013508:Ophthalmologic Surgical Procedures; D019736:Prostheses and Implants; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000379:methods*; D012756:Sheep; D013536:Suture Techniques; D014796:Visual Perception; D014821:Vitrectomy
chemical_list: D001672:Biocompatible Materials