Hypomagnesemic seizures: case report and presumed pathophysiology.
Hypomagnesemia has previously been recognized as an uncommon cause of seizures. The electrolyte abnormality is caused by poor gastrointestinal absorption or excessive renal wasting, both from a variety of causes. We report on a 5-week-old patient who developed hypomagnesemic seizures as a consequence of renal magnesium wasting. Although the exact pathophysiology of hypomagnesemic seizures remains uncertain, currently available information suggests that it is related to disinhibition of the N-methyl-D-aspartate-type glutamate receptor-sodium channel complex.
Weisleder
Pedro
P
Division of Child Neurology, Children's Health Center and Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA.
Tobin
Joshua A
JA
Kerrigan
John F
JF
Bodensteiner
John B
JB
D004829:Epilepsy, Generalized / Q000175:diagnosis / Q000209:etiology*; D004927:Escherichia coli Infections / Q000150:complications / Q000175:diagnosis; D006801:Humans; D006869:Hydronephrosis / Q000150:complications / Q000175:diagnosis; D007223:Infant; D008274:Magnesium / Q000652:urine; D008275:Magnesium Deficiency / Q000150:complications* / Q000175:diagnosis; D008297:Male; D014552:Urinary Tract Infections / Q000150:complications / Q000175:diagnosis; D014718:Vesico-Ureteral Reflux / Q000150:complications / Q000175:diagnosis
D008274:Magnesium