title: Benzoylphloroglucinol derivatives from Hypericum scabrum.
abstract: Nine new polyprenylated benzoylphloroglucinol derivatives, hyperibones A-I (1-9), were isolated from the aerial parts of the Uzbekistan medicinal plant Hypericum scabrum. Their structures were determined mainly on the basis of spectroscopic evidence (2D NMR and HRMS). Compounds 1, 2, and 4 showed mild in vitro antibacterial activity against methicillin-resistance Staphylococus aureus (MRSA) and methicillin-sensitive Staphylococus aureus (MSSA).
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, 770-8505, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shikishima
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.forename: Gisho
authors.initials: G
authors.lastname: Honda
authors.forename: Michiho
authors.initials: M
authors.lastname: Ito
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takeda
authors.forename: Hirohumi
authors.initials: H
authors.lastname: Shibata
authors.forename: Tomihiko
authors.initials: T
authors.lastname: Higuti
authors.forename: Olimjon K
authors.initials: OK
authors.lastname: Kodzhimatov
authors.forename: Ozodbek
authors.initials: O
authors.lastname: Ashurmetov
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004352:Drug Resistance, Microbial; D020902:Hypericum / Q000737:chemistry*; D016106:Methicillin Resistance / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects*; D014610:Uzbekistan
chemical_list: D000900:Anti-Bacterial Agents; D010696:Phloroglucinol