Biosynthesis and attachment of novel bacterial polyketide synthase starter units.
The biosynthesis and mode of attachment of a wide range of polyketide synthase (PKS) starter units in bacteria are covered in this review. Natural, unnatural, and engineered starter units associated with type I and type II PKSs are reported. The literature through early 2001 is reviewed, and 240 references cited.
Moore
Bradley S
BS
Division of Medicinal Chemistry, College of Pharmacy, University of Arizona, Tucson 85721-0207, USA. moore@pharmacy.arizona.edu
Hertweck
Christian
C
D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism*; D000900:Anti-Bacterial Agents; D001419:Bacteria / Q000201:enzymology*; D001952:Bridged-Ring Compounds / Q000737:chemistry; D002087:Butyrates / Q000737:chemistry; D002384:Catalysis; D004917:Erythromycin / Q000031:analogs & derivatives / Q000737:chemistry; D007559:Ivermectin / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D009097:Multienzyme Complexes / Q000096:biosynthesis* / Q000378:metabolism; D010455:Peptides; D011090:Polyenes / Q000737:chemistry; D053284:Polyunsaturated Alkamides; D011422:Propionates / Q000737:chemistry; D017828:Rifabutin / Q000031:analogs & derivatives / Q000737:chemistry; D012294:Rifamycins / Q000737:chemistry; D012459:Salicylates / Q000737:chemistry
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D001952:Bridged-Ring Compounds; D002087:Butyrates; D009097:Multienzyme Complexes; D010455:Peptides; D011090:Polyenes; D053284:Polyunsaturated Alkamides; D011422:Propionates; D012294:Rifamycins; D012459:Salicylates; D017828:Rifabutin; C012306:enterocin; D004917:Erythromycin; D007559:Ivermectin; C019264:avermectin; C054474:manumycin