[Theoretical studies of QTL analysis of complex genetic diseases in humans].
Some genes controlling human diseases have been located on the regions less than 1 cM using linkage disequilibrium, and a few of them have been cloned. Z. W. Luo developed a method that can detect and estimate the coefficient of linkage disequilibrium between a marker locus and quantitative trait locus (QTL), and raised the theoretical strategies for high-resolution mapping of complex genetic disorders in humans. Based on the data mentioned above, a method for linkage test between a marker locus and QTL was set up, and a method for linkage test between two marker loci and epistatic QTL was suggested for the first time.
Hu
Zhong-Li
ZL
Key Laboratory of MOE for Developmental Biology, Wuhan University, Wuhan 430072, China.
Dong
Wei-Guo
WG
Song
Yun-Chun
YC
D002874:Chromosome Mapping / Q000379:methods*; D003627:Data Interpretation, Statistical; D030342:Genetic Diseases, Inborn; D005819:Genetic Markers; D005828:Genetics, Population; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008957:Models, Genetic; D019655:Quantitative Trait, Heritable
D005819:Genetic Markers