Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus.
Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by gamma-aminobutyric acid type A (GABA(A)) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABA(A) receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.
Porjesz
Bernice
B
Department of Psychiatry, State University of New York, Health Science Center, Brooklyn, NY 11203, USA.
Almasy
Laura
L
Edenberg
Howard J
HJ
Wang
Kongming
K
Chorlian
David B
DB
Foroud
Tatiana
T
Goate
Alison
A
Rice
John P
JP
O'Connor
Sean J
SJ
Rohrbaugh
John
J
Kuperman
Samuel
S
Bauer
Lance O
LO
Crowe
Raymond R
RR
Schuckit
Marc A
MA
Hesselbrock
Victor
V
Conneally
P Michael
PM
Tischfield
Jay A
JA
Li
Ting-Kai
TK
Reich
Theodore
T
Begleiter
Henri
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D004569:Electroencephalography; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008126:Lod Score; D008875:Middle Aged; D005810:Multigene Family / Q000235:genetics; D019655:Quantitative Trait, Heritable; D011963:Receptors, GABA-A / Q000235:genetics*
D005819:Genetic Markers; D011963:Receptors, GABA-A