title: Oral delivery of antigens in liposomes with some lipid compositions modulates oral tolerance to the antigens.
abstract: Several liposomes containing ovalbumin (OVA), a model antigen, with different lipid compositions were prepared in order to evaluate their ability to induce oral tolerance. Oral administration of these liposomal OVAs induced suppression of the proliferative responses of popliteal lymph node cells from the treated mice to OVA, suggesting that these treated mice were tolerized. The efficiency of the induction of oral tolerance was affected by the liposome composition. OVA entrapment in these liposomes could modulate the tolerizing dose of OVA itself. These results suggest that some liposomes can be suitable antigen-delivery systems for modulated and/or effective induction of oral tolerance.
authors.affiliation: Shionogi Research Laboratories, Shionogi & Co, Ltd, Osaka, Japan. kazuyoshi.masuda@shionogi.co.jp
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Masuda
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Horie
authors.forename: Ryuji
authors.initials: R
authors.lastname: Suzuki
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Koichiro
authors.initials: K
authors.lastname: Hirano
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000941:Antigens / Q000008:administration & dosage* / Q000276:immunology; D004337:Drug Carriers; D007108:Immune Tolerance; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000941:Antigens; D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D010047:Ovalbumin