title: Role of Neisseria meningitidis luxS in cell-to-cell signaling and bacteremic infection.
abstract: Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS deletion are defective for bacteremia, a prerequisite of meningococcal pathogenesis.
authors.affiliation: Institute of Infections and Immunity, Queen's Medical Centre, Nottingham NG9 2EX. United Kingdom.
authors.forename: Klaus
authors.initials: K
authors.lastname: Winzer
authors.forename: Yao-hui
authors.initials: YH
authors.lastname: Sun
authors.forename: Andrew
authors.initials: A
authors.lastname: Green
authors.forename: Marie
authors.initials: M
authors.lastname: Delory
authors.forename: David
authors.initials: D
authors.lastname: Blackley
authors.forename: Kim R
authors.initials: KR
authors.lastname: Hardie
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Baldwin
authors.forename: Christoph M
authors.initials: CM
authors.lastname: Tang
mesh_terms: D000818:Animals; D016470:Bacteremia / Q000209:etiology*; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D013437:Carbon-Sulfur Lyases; D006714:Homoserine / Q000031:analogs & derivatives* / Q000032:analysis; D007783:Lactones / Q000032:analysis; D009345:Neisseria meningitidis / Q000235:genetics / Q000472:pathogenicity*; D051381:Rats; D017208:Rats, Wistar; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D007783:Lactones; C091088:N-octanoylhomoserine lactone; D006714:Homoserine; D013437:Carbon-Sulfur Lyases; C117753:LuxS protein, Bacteria