No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease.
Results from various genetic association studies of the lipoprotein lipase (LPL) S447X polymorphism and Alzheimer's disease (AD), range from a statistically significant negative association of clinically examined patients to a non-significant but consistent trend for under-representation of the X447 allele in neuropathologically confirmed subjects. In this report we have compared the distribution of the above polymorphism in an independent group of clinically diagnosed AD patients, including a subgroup where the disease was pathologically confirmed, and a spousal control group. No statistically significant differences emerged from this comparison. We conclude that LPL cannot be a major factor in pathogenesis of AD.
Fidani
Liana
L
Department of Pharmacology, School of Medicine, University of Thessaloniki, 54006, Greece. lfidani@aneslab.med.auth.gr
Compton
Danielle
D
Hardy
John
J
Petersen
Ronald C
RC
Tangalos
Eric
E
Mirtsou
Vassiliki
V
Goulas
Antonis
A
De Vrieze
Fabienne Wavrant
FW
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics
D001057:Apolipoproteins E; D005819:Genetic Markers; D008071:Lipoprotein Lipase