Are the insulin-like growth factors relevant to cancer?
Recognition of molecular pathways relevant to cancer biology have led to advances in prevention and treatment. Numerous laboratory and clinical investigations have implicated the insulin-like growth factors (IGFs) in tumourigenesis. In this review, the evidence for the involvement of IGFs in cancer is discussed. While these data are persuasive, it is clear that additional methods to regulate IGF action in cancer patients are needed to substantiate the role of this growth factor family in cancer biology.
Yee
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MMC 806, 420 Delaware Street SE, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA. yeexx006@umn.edu
D000818:Animals; D005260:Female; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D010641:Phenotype; D017451:Receptors, Somatomedin / Q000502:physiology; D015398:Signal Transduction; D013002:Somatomedins / Q000037:antagonists & inhibitors / Q000502:physiology*
D006727:Hormone Antagonists; D017451:Receptors, Somatomedin; D013002:Somatomedins