title: Effects of Opuntia ficus-indica var. Saboten stem on gastric damages in rats.
abstract: The effects of the dried stem powder of Opuntia ficus-indica var. saboten (OF-s) were investigated on gastric lesion and ulcer models in rats. It showed significant inhibition in HCl ethanol-induced gastric lesion at the doses of 200 and 600 mg/kg p.o. and in HCl.aspirin-induced gastric lesion at 600 mg/kg p.o. OF-s also showed significant inhibition in indomethacin-induced gastric lesion at the doses of 200 and 600 mg/kg, p.o. However, it did not affect both the aspirin-induced and Shay ulcers in rats. It also did not affect gastric juice secretion, acid output and pH. These data indicate that OF-s only possesses pronounced inhibitory action on gastric lesion without antiulcer activity in rats.
authors.affiliation: Natural Products Research Institute, Seoul National University, Seoul, Korea. eblee@snu.ac.kr
authors.forename: Eun Bang
authors.initials: EB
authors.lastname: Lee
authors.forename: Jin Ee
authors.initials: JE
authors.lastname: Hyun
authors.forename: Da Wei
authors.initials: DW
authors.lastname: Li
authors.forename: Yung In
authors.initials: YI
authors.lastname: Moon
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D000431:Ethanol; D030681:Ficus / Q000737:chemistry*; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D007213:Indomethacin; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D000431:Ethanol; D001241:Aspirin; D007213:Indomethacin