Seasonal atopic dermatitis in dogs sensitive to a major allergen of Japanese cedar (Cryptomeria japonica) pollen.
Three dogs were examined because of episodes of recurrent pruritic dermatitis in the spring, the season of Japanese cedar (Cryptomeria japonica, CJ) pollination in Japan. The dogs were shown to be sensitive to CJ pollen allergen using intradermal testing and antigen-specific IgE measurement. Fluorometric enzyme-linked immunosorbant assay (ELISA) showed increased concentrations of IgE specific to Cry j 1 and a negative result for Cry j 2 in the three dogs. The concentrations of IgE specific to Cry j 1 during the season of CJ pollination were higher than the concentrations found during the off-season in all the dogs, and the variation in the concentrations correlated with the variation in clinical signs. Peripheral blood mononuclear cells showed apparent proliferative responses to crude CJ pollen antigen and Cry j 1 during CJ pollination season. These findings indicated that Cry j 1 was the major allergen recognized by IgE and lymphocytes and resulted in the development of type I hypersensitivity to CJ pollen allergen in these atopic dogs.
Masuda
Kenichi
K
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan. amasuda@mail.ecc.u-tokyo.ac.jp
Sakaguchi
Masahiro
M
Saito
Saburo
S
Deboer
Douglas J
DJ
Yamashita
Kohei
K
Hasegawa
Atsuhiko
A
Ohno
Koichi
K
Tsujimoto
Hajime
H
D000485:Allergens / Q000009:adverse effects* / Q000276:immunology; D000818:Animals; D028203:Cedrus; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D007073:Immunoglobulin E / Q000097:blood; D007428:Intradermal Tests / Q000662:veterinary; D008297:Male; D011058:Pollen / Q000009:adverse effects* / Q000276:immunology; D012621:Seasons
D000485:Allergens; D007073:Immunoglobulin E