Mechanisms of eosinophil recruitment and activation.
The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the last two decades. While the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in humans and in animal models is less clear. However, recent developments in research on many organ systems have provided novel insights into the possible underlying role of the eosinophil in both allergic and nonallergic inflammation. This review examines the pathways associated with eosinophil recruitment and activation and discusses these findings, with reference to clinically defined categories.
Adamko
Darryl
D
Department of Medicine, University of Alberta, 550A HMRC, Edmonton, AB T6G 2S2, Canada.
Lacy
Paige
P
Moqbel
Redwan
R
D000818:Animals; D001249:Asthma / Q000276:immunology / Q000503:physiopathology; D015550:Cell Degranulation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D004804:Eosinophils / Q000502:physiology*; D006801:Humans