title: Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections.
abstract: To examine the role of T cell receptor (TCR) in gammadelta T cells in adaptive immunity, a macaque model was used to follow Vgamma2Vdelta2+ T cell responses to mycobacterial infections. These phosphoantigen-specific gammadelta T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vgamma2Vdelta2+ T cells were also seen during Mycobacterium tuberculosis infection of naive and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vgamma2Vdelta2+ T cells may contribute to adaptive immunity to mycobacterial infections.
authors.affiliation: Tuberculosis Research Unit, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shen
authors.forename: Dejiang
authors.initials: D
authors.lastname: Zhou
authors.forename: Liyou
authors.initials: L
authors.lastname: Qiu
authors.forename: Xioamin
authors.initials: X
authors.lastname: Lai
authors.forename: Meredith
authors.initials: M
authors.lastname: Simon
authors.forename: Ling
authors.initials: L
authors.lastname: Shen
authors.forename: Zhongchen
authors.initials: Z
authors.lastname: Kou
authors.forename: Qifan
authors.initials: Q
authors.lastname: Wang
authors.forename: Liming
authors.initials: L
authors.lastname: Jiang
authors.forename: Jim
authors.initials: J
authors.lastname: Estep
authors.forename: Robert
authors.initials: R
authors.lastname: Hunt
authors.forename: Michelle
authors.initials: M
authors.lastname: Clagett
authors.forename: Prabhat K
authors.initials: PK
authors.lastname: Sehgal
authors.forename: Yunyaun
authors.initials: Y
authors.lastname: Li
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zeng
authors.forename: Craig T
authors.initials: CT
authors.lastname: Morita
authors.forename: Michael B
authors.initials: MB
authors.lastname: Brenner
authors.forename: Norman L
authors.initials: NL
authors.lastname: Letvin
authors.forename: Zheng W
authors.initials: ZW
authors.lastname: Chen
mesh_terms: D000818:Animals; D007113:Immunity, Innate / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D008251:Macaca / Q000276:immunology* / Q000382:microbiology*; D009163:Mycobacterium bovis / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta