Granulocyte macrophage-colony stimulating factor and oral mucositis.
OBJECTIVE
To evaluate the effect of granulocyte macrophage-colony stimulating factor (GM-CSF) in patients with oral mucositis.


METHODS
Literature was accessed through MEDLINE (1966-June 2000) and bibliographic searches.


RESULTS
Published literature assessing the use of GM-CSF to treat or prevent oral mucositis was analyzed.


CONCLUSIONS
Reports of GM-CSF improving mucositis have been published; however, because of limitations in these reports, insufficient evidence confirms the benefits of GM-CSF. These preliminary studies provide a rationale to conduct well-designed, double-blind, randomized trials to evaluate the safety and efficacy of GM-CSF in the treatment and/or prevention of oral mucositis induced by chemotherapy and/or radiotherapy.
Fung
Stacey M
SM
Medical Affairs, Protein Design Labs, Inc., Fremont CA 94555-3617, USA. sfung@pdl.com
Ferrill
Mary J
MJ
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology / Q000627:therapeutic use*; D006801:Humans; D009061:Mouth Mucosa / Q000187:drug effects; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index; D013280:Stomatitis / Q000145:classification / Q000188:drug therapy* / Q000517:prevention & control
D016178:Granulocyte-Macrophage Colony-Stimulating Factor