title: Molecular analysis of cancer. An overview.
abstract: Human cancers are generally characterized by acquisition of a series of somatic mutations. Molecular techniques, such as those described in this volume, have been used to identify a plethora of chromosomal translocations and mutations associated with carcinogenesis. The analysis and comparison of the array of genetic changes occurring in malignancy will enable a move toward a better understanding of cancer development. This will eventually lead to the development of improved therapies tailored to take into account the cytogenetic and molecular characteristics of specific human cancers.
authors.affiliation: Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK.
authors.forename: Ken
authors.initials: K
authors.lastname: Mills
mesh_terms: D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008745:Methylation; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000503:physiopathology*; D020411:Oligonucleotide Array Sequence Analysis; D017422:Sequence Analysis, DNA / Q000379:methods; D019098:Telomerase / Q000378:metabolism
chemical_list: D019098:Telomerase