title: The study on organic nitrates, part V. New derivatives of piperazine potential NO donors.
abstract: We have obtained a series of non-symmetrical 1,4-disubstituted derivatives of piperazine, with the structure of organic nitrates, as potential NO donors. These compounds were obtained from respective hydroxyl derivatives of piperazine in an esterification reaction by fuming nitric acid. The obtained nitrates were tested in-vitro by reaction with a sulfhydryl compound. The structure of the most active nitrate and its hydroxyl analogue was used for the calculation of geometrical optimization with the determination of 3D-QSAR by a semi-empirical method PM3 using HyperChem 4.5.
authors.affiliation: Department of Pharmaceutical Chemistry and Drug Analyses, Medical University, Lódź, Poland.
authors.forename: Lucyna
authors.initials: L
authors.lastname: Korzycka
mesh_terms: D004951:Esterification; D009566:Nitrates / Q000138:chemical synthesis* / Q000737:chemistry; D009569:Nitric Oxide / Q000737:chemistry; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D009566:Nitrates; D010879:Piperazines; D009569:Nitric Oxide