title: Melatonin and circadian rhythms.
abstract: Melatonin synthesis and secretion by the pineal gland is under the control of the suprachiasmatic nucleus and consequently has a profound circadian rhythm. In this review we discuss some of the issues surrounding the measurement of melatonin rhythmicity in biological fluids and the factors that influence melatonin circadian rhythmicity, including light and drugs. We also review the role of melatonin rhythmicity in sleep timing and sleep initiation.
authors.affiliation: Department of Obstetrics and Gynaecology, Adelaide University, Medical School, South Australia.
authors.forename: David J
authors.initials: DJ
authors.lastname: Kennaway
authors.forename: Helen
authors.initials: H
authors.lastname: Wright
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D004347:Drug Interactions; D006801:Humans; D008027:Light; D008550:Melatonin / Q000502:physiology* / Q000528:radiation effects; D012890:Sleep / Q000187:drug effects
chemical_list: D008550:Melatonin