Amino aciduria in weightlessness.
Urinary excretion of amino acids by the 9 Skylab crewmen was studied as an indicator of the metabolic effects caused by exposure to the space flight environment. Intake was consistent in quality and quantity throughout the 28, 59 and 84-day flights for each of the crewmen and complete collections were accomplished. The results indicated an increased excretion in most amino acids during the first month of flight which remained elevated in the second and third months but to a lesser extent. Additional indications of change in muscle and skeletal metabolism were observed. These results point to the desirability of obtaining additional indices of alterations in protein synthetic processes in conjunction with future space flights.
Leach
C S
CS
Lyndon B. Johnson Space Center, National Aeronautics and Space Administration, Houston, TX 77058, USA.
Rambaut
P C
PC
Di Ferrante
N
N
D000222:Adaptation, Physiological; D000596:Amino Acids / Q000378:metabolism* / Q000652:urine*; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D006901:Hydroxylysine / Q000031:analogs & derivatives / Q000378:metabolism / Q000652:urine; D006909:Hydroxyproline / Q000378:metabolism / Q000652:urine; D008297:Male; D008762:Methylhistidines / Q000378:metabolism / Q000652:urine; D013026:Space Flight; D014893:Weightlessness
D000596:Amino Acids; D008762:Methylhistidines; C022819:hydroxylysine glycoside; D006901:Hydroxylysine; C028118:3-methylhistidine; D006909:Hydroxyproline