Haematopoietic cell-fate decisions, chromatin regulation and ikaros.
The regulated production of several terminally differentiated cell types of the blood and immune systems (haematopoiesis) has been the focus of many studies on cell-fate determination. Chromatin and the control of its structure have been implicated in the regulation of cell-fate decisions and in the maintenance of the determined states. Here, I review advances in the field, emphasizing the potential role of chromatin in lineage commitment and differentiation. In this context, I discuss Ikaros, an essential regulator of lymphocyte development and an integral component of a functionally diverse chromatin remodelling network that operates from the early stages of haematopoiesis to the mature lymphocytes.
Georgopoulos
Katia
K
CBRC, MGH East, 13th St, Charlestown, Massachusetts 02129, USA. katia.georgopoulos@cbrc2.mgh.harvard.edu
D000818:Animals; D019070:Cell Lineage; D002843:Chromatin / Q000502:physiology*; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006657:Histones / Q000378:metabolism; D006801:Humans; D051740:Ikaros Transcription Factor; D014157:Transcription Factors / Q000737:chemistry / Q000502:physiology*
D002843:Chromatin; D004268:DNA-Binding Proteins; D006657:Histones; C497239:IKZF1 protein, human; D014157:Transcription Factors; D051740:Ikaros Transcription Factor; D004247:DNA