title: Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection.
abstract: A novel adoptive transfer system was used to track the fate of naive Salmonella-specific CD4 T cells in vivo. These cells showed signs of activation in the Peyer's patches as early as 3 hr after oral infection. The activated CD4 T cells then produced IL-2 and proliferated in the T cell areas of these tissues before migrating into the B cell-rich follicles. In contrast, Salmonella-specific CD4 T cells were not activated in the spleen and very few of these cells migrated to the liver, despite the presence of bacteria in both organs. These results show that the T cell response to pathogenic Salmonella infection is localized to the gut-associated lymphoid tissue and does not extend efficiently to the major sites of late infection.
authors.affiliation: Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. mcsorley@uchc.edu
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: McSorley
authors.forename: Sarah
authors.initials: S
authors.lastname: Asch
authors.forename: Massimo
authors.initials: M
authors.lastname: Costalonga
authors.forename: R Lee
authors.initials: RL
authors.lastname: Reinhardt
authors.forename: Marc K
authors.initials: MK
authors.lastname: Jenkins
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D007111:Immunity, Cellular; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D007421:Intestine, Small / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009928:Organ Specificity; D010581:Peyer's Patches / Q000276:immunology*; D012475:Salmonella / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000276:immunology*; D013154:Spleen / Q000276:immunology