[Serum levels of proinflammatory cytokines in women with uterine myomas].
The levels of proinflammatory cytokines, namely IL-1 alpha, IL-6 and TNF-alpha were determined in blood serum of 26 women with uterine myomas and in 20 healthy controls. A significantly elevated concentration of IL-1 alpha was found in patients with uterine myomas. Levels of IL-6 and TNF-alpha were insignificantly higher in women with myomas. The obtained results indicate the possible role of IL-1 alpha in the pathogenesis of uterine myomas--further studies are needed to elucidate the role of proinflammatory cytokines in the proliferative disorders of myometrium.
Sikorski
R
R
III Katedry i Kliniki Ginekologii AM w Lublinie.
Kapeć
E
E
Zaleska
W
W
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D007889:Leiomyoma / Q000276:immunology*; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000276:immunology*
D014408:Biomarkers, Tumor; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha