Curative effect of wilsonii injecta on severe head injury.
OBJECTIVE
To study the curative effect of wilsonii injecta on severe head injury (SHI).


METHODS
A total of 120 patients with SHI were divided randomly into 2 groups, the patients treated with conventional methods as Group A (n=60) and the patients treated with wilsonii injecta as Group B (n=60). The changes of neural function indexes were evaluated with Glasgow Coma Scale (GCS) before treatment and with Glasgow Outcome Scale (GOS) after treatment, simultaneously, the parameters of hemorrheological indexes (HI), brain electrical activity map (BEAM) and transcranial Doppler sonography (TCD) were observed before and after treatment.


RESULTS
In Group B, the clinical GCS, the HI, the BEAM and the prognosis GOS were improved much more than those in Group A. And the TCD parameters in Group B decreased, which had significant difference compared with that in Group A (P<0.01).


CONCLUSIONS
Wilsonii injecta can rapidly improve the injured p ersons' conscious states, the abnormal BEAM and the surviving quality. It suggests that the improvement of the HI is related to the relief of the vasospasm of the arterial blood vessels in the brain, which may be one of the important mechanisms of wilsonii injecta in improving the prognosis.
Chen
Ligang
L
Department of Neurosurgery, General Hospital of Chengdu Military Command, Chengd u 610083, China.
Zeng
Fanjun
F
Yang
Libin
L
Chai
Jiankang
J
Li
Kaihui
K
Lu
Min
M
Kuang
Yongqin
Y
D000328:Adult; D001930:Brain Injuries / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001931:Brain Mapping; D005260:Female; D005500:Follow-Up Studies; D015600:Glasgow Coma Scale; D023261:Glasgow Outcome Scale; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D011336:Probability; D012016:Reference Values; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler
D010936:Plant Extracts