The role of the gut lymphoid tissue in induction of oral tolerance.
The gut-associated lymphoid tissue (GALT) maintains a balance between immunological tolerance to dietary proteins and induction of active immune responses to pathogenic microorganisms. The oral administration of soluble protein antigens induces a state of systemic immunological unresponsiveness specific to the fed protein, termed oral tolerance. The two major mechanisms to explain oral tolerance are anergy/deletion of autoreactive lymphocytes and active suppression. This review will discuss the mechanisms of therapeutic oral tolerance in relation to events occurring at the site of antigen entry.
Song
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Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, College of Medicine and Public Health, Columbus 43210, USA. song.89@osu.edu
Whitacre
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CC
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D004044:Dietary Proteins / Q000009:adverse effects*; D004064:Digestive System / Q000276:immunology / Q000503:physiopathology*; D005512:Food Hypersensitivity / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology / Q000503:physiopathology*; D008954:Models, Biological
D004044:Dietary Proteins