title: [Toxico-genetic risk factors for adolescents living in a large industrial city].
abstract: Cytogenetic study of adolescents in a large industrial city (n = 211) and donors (n = 41) showed an increase in the number of chromosomal aberrations per 100 lymphocytes in urban adolescents from 1.58 +/- 0.41 in 1992 to 4.53 +/- 0.48 in 1996. A significant increase in the spontaneous level of aberrations (2.02 +/- 0.21) was observed starting from 1993. Time course of the number of chromosomal aberrations and components of the environment (radiation background, chemical pollution of potable water, foodstuffs, and atmospheric air) in the city of Kemerovo in 1992-1996 are compared. According to the data of analysis of correlations, the most significant genotoxicants are nitrogen oxide (II), methanol, and benz(a)pyrene.
authors.forename: A N
authors.initials: AN
authors.lastname: Volkov
authors.forename: V G
authors.initials: VG
authors.lastname: Druzhinin
mesh_terms: D000293:Adolescent; D000328:Adult; D002391:Catchment Area, Health; D025063:Chromosome Disorders / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics*; D003582:Cytogenetics / Q000379:methods; D015386:Hazardous Substances / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007221:Industry; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology
chemical_list: D015386:Hazardous Substances