title: Renal uptake rate measurement of 99m Tc-dimercaptosuccinic acid using spectral analysis.
abstract: We developed a new method for measuring the rate of renal uptake of 99mTc-dimercaptosuccinic acid (DMSA) using spectral analysis. The renal uptake rate (per minute) of DMSA (K) was calculated by averaging the tissue impulse response function values obtained by spectral analysis between 10 min and 15 min. The K values obtained by spectral analysis correlated well with the renal uptake rates (%) measured 2h after DMSA administration (r=0.921 with background correction; r=0.924 without background correction). There was a good agreement between the K values obtained by spectral analysis using the kidney time-activity curves with (x) and without (y) background correction (r=0.993, y=1.089x+0.004), suggesting that our method requires no background correction. There was excellent correlation between the K values obtained by spectral analysis using the kidney time-activity curves with (y) and without (x) kidney depth correction (r=0.992, y=1.721x+0.000 with background correction; r=0.990, y=1.720x+0.000 without background correction), suggesting that our method requires no kidney depth correction. These results indicate that spectral analysis is appropriate and useful for the quantification of renal uptake rate of DMSA. We believe that this method will facilitate even more widespread utilization of the quantitative assessment of DMSA uptake by planar scintigraphy, since it needs only 10-15 min for imaging, and background and kidney depth correction and blood sampling are not required.
authors.affiliation: Department of Medical Engineering, Division of Allied Health Sciences, Osaka University Medical School, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan. murase@sahs.med.osaka-u.ac.jp
authors.forename: Kenya
authors.initials: K
authors.lastname: Murase
authors.forename: Youichi
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Teruhito
authors.initials: T
authors.lastname: Mochizuki
authors.forename: Junpei
authors.initials: J
authors.lastname: Ikezoe
mesh_terms: D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000378:metabolism*; D016018:Least-Squares Analysis; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012680:Sensitivity and Specificity; D019783:Technetium Tc 99m Dimercaptosuccinic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid