[Expression of the protein marker p16INK4a in the cervix uteri cancer].
Immunohistochemical study was carried out of 18 cervical carcinomas (13 squamous and 5 adenomatous) and of 3 cases of cervical intraepithelial dysplasia. Formalin-fixed paraffin-embedded tissue samples from biopsies as well as from surgical material were used. Staining was performed with monoclonal antibodies to protein p16INK4a. Cytologic smears of epithelial cervical cells from 7 healthy women were taken as a negative control. The reference group consisted of 5 cancer patients with other tumors (breast cancer, B-cell lymphoma). Overexpression of p16INK4a was registered in cervical cancer.
Volgareva
G M
GM
N.N. Blokhin Cancer Research Center, 115478, Moscow.
Zavalishina
L E
LE
Frank
G A
GA
Andreeva
Iu Iu
IuIu
Petrov
A N
AN
Kiselev
F L
FL
Spitkovskiĭ
D D
DD
D000230:Adenocarcinoma / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002578:Uterine Cervical Dysplasia / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*
D014408:Biomarkers, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16