title: Haematopoietic cell-fate decisions, chromatin regulation and ikaros.
abstract: The regulated production of several terminally differentiated cell types of the blood and immune systems (haematopoiesis) has been the focus of many studies on cell-fate determination. Chromatin and the control of its structure have been implicated in the regulation of cell-fate decisions and in the maintenance of the determined states. Here, I review advances in the field, emphasizing the potential role of chromatin in lineage commitment and differentiation. In this context, I discuss Ikaros, an essential regulator of lymphocyte development and an integral component of a functionally diverse chromatin remodelling network that operates from the early stages of haematopoiesis to the mature lymphocytes.
authors.affiliation: CBRC, MGH East, 13th St, Charlestown, Massachusetts 02129, USA. katia.georgopoulos@cbrc2.mgh.harvard.edu
authors.forename: Katia
authors.initials: K
authors.lastname: Georgopoulos
mesh_terms: D000818:Animals; D019070:Cell Lineage; D002843:Chromatin / Q000502:physiology*; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006657:Histones / Q000378:metabolism; D006801:Humans; D051740:Ikaros Transcription Factor; D014157:Transcription Factors / Q000737:chemistry / Q000502:physiology*
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D006657:Histones; C497239:IKZF1 protein, human; D014157:Transcription Factors; D051740:Ikaros Transcription Factor; D004247:DNA