The contribution of nuclear compartmentalization to gene regulation.
Recent developments in live-cell imaging are challenging our stereotyped view of the fixed cell nucleus. The emerging picture is that nuclear processes may rely on a constant flow of molecules between dynamic compartments created by relatively immobile binding or assembly sites. This article discusses current views on the origins of nuclear compartments and their roles in gene expression.
Carmo-Fonseca
Maria
M
Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal. carmo.fonseca@fm.ul.pt
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D000818:Animals; D002451:Cell Compartmentation; D002466:Cell Nucleolus / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic / Q000502:physiology
D002843:Chromatin; D009687:Nuclear Proteins; D014157:Transcription Factors