title: Isolated pentasomy of chromosome 8 in erythroleukemia.
abstract: Pentasomy 8 as a sole anomaly in hematological disorders is rare. Only 2 such cases, one in acute monocytic leukemia and one in chronic myelomonocytic leukemia have been described in the literature to date. Here, we report the first case of a 42 year old man with erythroleukemia displaying a pentasomy 8 clone. Conventional cytogenetics of bone marrow cells showed 16 metaphases with pentasomy 8 and 9 with normal diploidy. Fluorescence in situ hybridization (FISH) analysis using a whole chromosome painting probe and a centromeric probe specific for chromosome 8 confirmed the presence of pentasomy 8 and also revealed a low percentage of a trisomic and a tetrasomic clone. The patient died three days after diagnosis without chemotherapy. The findings suggest that pentasomy 8 is associated with a heterogeneous group of myeloid disorders and probably plays a specific role in the progression of myeloid neoplasia.
authors.affiliation: Department of Haematology, George Papanicolaou General Hospital, Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Athanasiadou
authors.forename: R
authors.initials: R
authors.lastname: Saloum
authors.forename: M
authors.initials: M
authors.lastname: Gaitatzi
authors.forename: A
authors.initials: A
authors.lastname: Anagnostopoulos
authors.forename: A
authors.initials: A
authors.lastname: Fassas
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics*; D008297:Male