title: Megistoquinones I and II, two quinoline alkaloids with antibacterial activity from the bark of Sarcomelicope megistophylla.
abstract: Two alkaloids, megistoquinone I (1) and megistoquinone II (2), were isolated from the bark of Sarcomelicope megistophylla. Their structures have been elucidated on the basis of MS and NMR data. Both belong to quinoline alkaloid series and should be considered as oxidation products of a furo[2,3-b]quinoline precursor. The two alkaloids showed antibacterial properties with minimum inhibitory concentration (MIC) ranging from 2.35 to 5.25 mg/ml for 1 and 0.73 to 1.23 mg/ml for 2.
authors.affiliation: Department of Pharmacy, University of Athens, Greece.
authors.forename: Nikolas
authors.initials: N
authors.lastname: Fokialakis
authors.forename: Prokopios
authors.initials: P
authors.lastname: Magiatis
authors.forename: Ioanna
authors.initials: I
authors.lastname: Chinou
authors.forename: Sofia
authors.initials: S
authors.lastname: Mitaku
authors.forename: François
authors.initials: F
authors.lastname: Tillequin
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D011804:Quinolines; C465553:megistoquinone I; C465552:megistoquinone II