Immunohistochemical localization of the somatostatin receptor subtype 2A in the rat adrenal gland.
The immunohistochemical localization of the somatostatin receptor subtype sst2A was investigated in the rat adrenal gland using SS-800 polyclonal antibody. The sst2A immunopositivity was found in all adrenocortical zones and in adrenal medulla, the reaction being slightly more intense in zona glomerulosa and medulla. The administration of the potent agonist of sst2 receptors - octreotide - resulted in the enhancement of the immunopositivity in zona glomerulosa and medulla, whereas chronic exposure of the rats to diethylstilbestrol led to enhancement of the immunopositivity in zona glomerulosa and in the external part of zona fasciculata.
Pisarek
Hanna
H
Department of the Experimental Endocrinology and Hormone Diagnostics, Institute of Endocrinology, Medical University, Lódź, Poland.
Pawlikowski
Marek
M
D000302:Adrenal Cortex / Q000166:cytology / Q000378:metabolism*; D000313:Adrenal Medulla / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D004054:Diethylstilbestrol / Q000378:metabolism / Q000494:pharmacology; D004971:Estrus / Q000502:physiology; D007150:Immunohistochemistry; D008297:Male; D015282:Octreotide / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017481:Receptors, Somatostatin / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism*
D017481:Receptors, Somatostatin; C106140:somatostatin receptor sst2A; D013004:Somatostatin; D004054:Diethylstilbestrol; D015282:Octreotide