Myocardial infarction/injury is relatively common at presentation of acute thrombotic thrombocytopenic purpura: the Indiana University experience.
Although widespread vascular thrombosis is common in thrombotic thrombocytopenic purpura (TTP), there have been no prospective studies on the extent of injury to specific organs. Following successful resuscitation and plasma exchange of an index patient with widespread organ dysfunction, cardiogenic shock, and elevated cardiac troponin-I levels, we prospectively studied and identified 2 more individuals (of 10 consecutive patients) with evidence of myocardial injury/infarction at presentation of acute TTP. These data suggest that cardiac troponin-I measurements should be considered during initial evaluation of all patients with acute TTP.
McCarthy
Leo J
LJ
Department of Pathology and Laboratory Medicine, Transfusion Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA. lmmcarth@iupui.edu
Danielson
Constance F M
CF
Skipworth
Elaine M
EM
Peters
Shelley L
SL
Miraglia
Charles C
CC
Antony
Asok C
AC
D000328:Adult; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009203:Myocardial Infarction / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D011446:Prospective Studies; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000453:epidemiology; D019210:Troponin I / Q000097:blood
D019210:Troponin I