title: Rofecoxib: a possible cause of acute colitis.
abstract: Nonsteroidal antiinflammatory agents may cause relevant small bowel and colonic side effects, apart from gastroduodenal lesions. The synthesis of selective cyclooxygenase-2 (COX-2) inhibitors has been an important breakthrough in antiinflammatory therapy by decreasing the incidence of upper gastrointestinal lesions. However, there is little information available concerning their effects on gut mucosa distally to the duodenum. A case history is described of a 52-year-old woman with a temporary colostomy after resection of a sigmoid tumor and who presented with bloody diarrhea 5 days after beginning therapy with rofecoxib. The hemorrhage had its origin in the transverse colon, and the endoscopic appearance was that of actively bleeding acute hemorrhagic colitis. No other colonic lesions were detected, nor was there any evidence of related infection, bleeding diathesis, or other systemic diseases. On discontinuing rofecoxib and instituting parenteral rehydration, the bleeding and diarrhea stopped. Endoscopic follow-up revealed regenerating mucosa in the transverse colon. The time relation, the absence of other causes of hemorrhage, and the clinical evolution all strongly support the probability of a causal relation between rofecoxib and hemorrhagic colitis. This case may raise awareness concerning the possibility of colonic lesions related to the new COX-2 inhibitors, similar to what is known about nonselective antiinflammatory agents.
authors.affiliation: Digestive Endoscopy Unit, Hospital Garcia de Orta, Almada, Portugal. gastro@mail.pt
authors.forename: João
authors.initials: J
authors.lastname: Freitas
authors.forename: Vitor
authors.initials: V
authors.lastname: Farricha
authors.forename: Isabel
authors.initials: I
authors.lastname: Nascimento
authors.forename: Paula
authors.initials: P
authors.lastname: Borralho
authors.forename: António
authors.initials: A
authors.lastname: Paramés
mesh_terms: D000208:Acute Disease; D003092:Colitis / Q000139:chemically induced*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007783:Lactones / Q000009:adverse effects* / Q000627:therapeutic use; D017116:Low Back Pain / Q000188:drug therapy; D008875:Middle Aged; D013450:Sulfones
chemical_list: D016861:Cyclooxygenase Inhibitors; D007783:Lactones; D013450:Sulfones; C116926:rofecoxib