title: Daily exercise reduces measures of heart rate and blood pressure variability in hypertensive rats.
abstract: This study was designed to test the hypothesis that daily spontaneous running (DSR) reduces measures of heart rate and blood pressure variability in spontaneously hypertensive rats (SHR). After 8 weeks of DSR or sedentary control, rats were chronically instrumented with arterial catheters. Daily exercise reduced most measures of heart rate (HR) and blood pressure variability. Specifically DSR decreased heart rate, Low Frequency Power (LF: 0.19-0.61 Hz), and Low Frequency/High Frequency (HF: 1.2-2.5 Hz) ratio of HR. Furthermore, Total Power (TP), LF power, and LF/HF ratio of systolic blood pressure were reduced by daily spontaneous running. Finally, TP, LF and HF powers and LF/HF ratios of diastolic blood pressure were reduced by daily spontaneous running. These data demonstrate that daily exercise reduces sympathetic activity and possibly increases cardiac reserve in hypertensive animals.
authors.affiliation: Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: DiCarlo
authors.forename: H L
authors.initials: HL
authors.lastname: Collins
authors.forename: D W
authors.initials: DW
authors.lastname: Rodenbaugh
authors.forename: M R
authors.initials: MR
authors.lastname: Smitha
authors.forename: R D
authors.initials: RD
authors.lastname: Berger
authors.forename: V K
authors.initials: VK
authors.lastname: Yeragani
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006973:Hypertension / Q000503:physiopathology* / Q000517:prevention & control; D009043:Motor Activity / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR