title: Topical applications of trichloroacetic acid as therapy for nasal allergy.
abstract: A group of 22 patients (27 nostrils) with nasal allergies was treated with 80 w/v trichloroacetic acid applied to the inferior turbinates. Patients were then evaluated prospectively based on both subjective responses and clinical examinations. Allergic symptoms were reduced significantly, especially those involving nasal obstruction and watery rhinorrhea. Nasal airflow resistance also improved after treatment (P < 0.001). Nasal provocation testing revealed a significant decrease in post-treatment responses (P < 0.001). No severe side effects were noted after treatment. Findings demonstrated that local application of trichloroacetic acid is a safe, effective and simple treatment for outpatients with symptomatic nasal allergies.
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Honda
authors.forename: K
authors.initials: K
authors.lastname: Ooki
authors.forename: K
authors.initials: K
authors.lastname: Makishima
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D002424:Caustics / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015508:Nasal Obstruction / Q000175:diagnosis / Q000209:etiology; D011446:Prospective Studies; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000188:drug therapy*; D025363:Rhinomanometry / Q000379:methods; D012720:Severity of Illness Index; D014238:Trichloroacetic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D002424:Caustics; D014238:Trichloroacetic Acid