Human lymphocyte antigen DR7 protects against proliferative retinopathy with type II diabetes mellitus.
BACKGROUND
This study was undertaken in order to analyze the genetic incidence of human lymphocyte antigen diabetic retinopathy (HLA-DR) and its influence in proliferative diabetic retinopathy (PDR).


METHODS
We designed a case-control study in which 127 mestizo Mexican patients with DM II and diabetic retinopathy were studied. DNA was extracted and HLA-DR regions were amplified using PCR. Alleles were determined by DNA hybridization. Diagnosis was assessed clinically and by fluorescein angiography. Incidence of HLA-DR alleles in patients was compared with an ethnically matched control group of healthy subjects (n = 98). Statistical significance was established with non-parametric tests.


RESULTS
Patients with diabetic retinopathy showed less frequency of HLA-D11 compared with the control group (p = 0.043). NPDR patients with 10 or more years of DM II showed an increase of HLA-DR7 (p = 0.01).


CONCLUSIONS
Our results suggest that the presence of HLA-DR7 protects against the development of proliferative disease in the diabetic Mexican population.
Quiroz-Mercado
Hugo
H
Servicio de Retina, Hospital Luis Sánchez Bulnes, Asociación para Evitar la Ceguera en México (AECM), Calle Vicente García Torres #46, Col. San Lucas Coyoacán, 04030 Mexico City, D.F., Mexico. retinamex@yahoo.com
Suárez-Licona
Ana
A
Fromow-Guerra
Jans
J
López-Carasa
Gabriela
G
Cárdenas-Hernández
Rubén
R
Ruiz-Morales
Jorge A
JA
Portal-Celhay
Cynthia
C
Granados
Julio
J
D000368:Aged; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000276:immunology; D003930:Diabetic Retinopathy / Q000235:genetics* / Q000276:immunology; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D015809:HLA-DR7 Antigen / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D008297:Male; D008800:Mexico; D008875:Middle Aged
D015809:HLA-DR7 Antigen