[The atherogenic lipid profile parameters and fibrinogen serum concentration in climacteric women under various routes of hormone replacement therapy administration].
OBJECTIVE
Influence of various routes of HTR on atherogenic lipid profile parameters and serum fibrinogen concentration was investigated.


METHODS
In 85 women in four groups receiving HRT transvaginally, transdermally, orally and intramuscularly, the total cholesterol, HDL-cholesterol, triglycerides, apoB, apoA, LpA and fibrinogen serum concentration was assessed before treatment and after six month.


RESULTS
Most of tested parameters: total cholesterol, LpAI, apoB, LDL cholesterol, non HDL cholesterol, changed favorably (lowered concentration) in group using HRT orally and intramuscularly.


CONCLUSIONS
Orally and intramuscularly route of administration HRT have better cardioprotective effects.
Gadomska
H
H
I Katedry i Kliniki Połoznictwa i Ginekologii AM w Warszawie.
Grzechocińska
B
B
Nowicka
G
G
Marianowski
L
L
Siemińska
J
J
D000279:Administration, Cutaneous; D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D002979:Climacteric / Q000097:blood* / Q000187:drug effects; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D007273:Injections, Intramuscular; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D008055:Lipids; D014280:Triglycerides; D005340:Fibrinogen; D002784:Cholesterol