Understanding atherosclerosis through mouse genetics.
During the past year studies with mouse models have significantly clarified our understanding of atherosclerosis. Noteworthy achievements include: the discovery of a number of novel genes and pathways; new evidence emphasizing the role of lymphocytes in atherogenesis; the development of mouse models exhibiting advanced lesions with evidence of thrombosis; and new results indicating an anti-atherogenic effect of testosterone.
Sheth
Sonal S
SS
Department of Human Genetics, UCLA School of Medicine, Los Angeles, California 90095, USA.
Deluna
Andres
A
Allayee
Hooman
H
Lusis
Aldons J
AJ
D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics* / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D051379:Mice / Q000235:genetics*; D008967:Molecular Biology
D008074:Lipoproteins