title: ADAM-mediated shedding and adhesion: a vascular perspective.
abstract: Proteolytic conversion (shedding) of membrane-bound proteins to soluble forms is a novel regulatory mechanism mediated by enzymes called a disintegrin and metalloproteases (ADAMs). In this review, the potential importance of ADAMs in vascular physiology and disease, especially in relation to atherosclerosis, will be highlighted.
authors.affiliation: Cardiovascular Research Division, Institute of Physiology, University of Zurich, CH-8057 Zurich, Switzerland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Herren
mesh_terms: D001161:Arteriosclerosis / Q000503:physiopathology*; D019483:Disintegrins / Q000502:physiology*; D006801:Humans; D008666:Metalloendopeptidases / Q000502:physiology*
chemical_list: D019483:Disintegrins; D008666:Metalloendopeptidases