[Determination of antioxidative-peroxidative balance in the cord blood of newborns delivered to mothers with diabetes type G1].
The aim of the study was to evaluate antioxidant system activity and lipid peroxidations products as markers of oxidative stress in the cord blood of newborns delivered to mothers with diabetes type G1 in comparison to healthy pregnant women.


METHODS
We examined 10 healthy and 10 diabetic mothers' newborns. Total antioxidant status (TAS) and thiobarbituric acid reactive substances (TBARS) were measured using spectrophotometry. We compared also birth weight, gestational age, Apgar score and cord blood pH between groups.


RESULTS
There were no significant differences in birth weight, gestational age, Apgar score and pH value between the groups. We found two cases of congenital malformations and two severe hyperbilirubinemia in diabetic mothers' newborns. We found also decreased level of TAS and higher level of TBARS in the cord blood of newborns delivered to mothers with diabetes type G1 in comparison to the control group.


CONCLUSIONS
Our results suggest that maternal diabetes G1 during pregnancy induces oxidative stress in the newborn.
Bis-Głuchowska
M
M
Katedry i Kliniki Połoznictwa i Perinatologii w Lublinie.
Marciniak
B
B
Szpringer-Boguń
E
E
Rola
R
R
Leszczyńska-Gorzelak
B
B
Oleszczuk
J
J
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001034:Apgar Score; D001724:Birth Weight; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D015227:Lipid Peroxidation; D018384:Oxidative Stress; D011247:Pregnancy; D013053:Spectrophotometry; D018709:Statistics, Nonparametric; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*
D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances