title: Secretory carcinoma of the breast: a tumour analogous to salivary gland acinic cell carcinoma?
abstract: OBJECTIVE
  Acinic cell-like breast carcinoma is a newly recognized entity, and few acinic cell-like breast carcinoma cases have been reported. All reported acinic cell-like breast carcinomas were counterparts of the solid type of acinic cell carcinoma of the salivary gland. We report here three cases of secretory breast carcinoma with acinic cell differentiation, and discuss the similarity between secretory breast carcinoma and acinic cell carcinoma of the salivary gland.
  
  
  RESULTS
  The cases were histologically identical to acinic cell carcinoma of the salivary gland: papillary-cystic type in case 1, a mixture of papillary-cystic, microcystic and follicular type in case 2, and microfollicular type in case 3. Immunohistochemically, the tumour cells were positive for salivary-type amylase, lysozyme, S100 protein and alpha 1-antitrypsin, and negative or less reactive for gross cystic disease fluid protein-15 and oestrogen receptor. All three cases did not reveal metastasis or recurrence.
  
  
  CONCLUSIONS
  These cases were typical of secretory breast carcinoma, and were clinically, histologically and immunohistochemically analogous to acinic cell carcinoma of the salivary gland. We emphasize that secretory breast carcinoma and acinic cell carcinoma of the salivary gland may be identical lesions.
authors.affiliation: Department of Pathology, University of Tokushima School of Medicine, Tokushima, Japan. hirokawa@basic.med.tokushima-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Hirokawa
authors.forename: K
authors.initials: K
authors.lastname: Sugihara
authors.forename: T
authors.initials: T
authors.lastname: Sai
authors.forename: Y
authors.initials: Y
authors.lastname: Monobe
authors.forename: H
authors.initials: H
authors.lastname: Kudo
authors.forename: N
authors.initials: N
authors.lastname: Sano
authors.forename: T
authors.initials: T
authors.lastname: Sano
mesh_terms: D000328:Adult; D000681:Amylases / Q000032:analysis; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology*; D018267:Carcinoma, Acinar Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007150:Immunohistochemistry; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000473:pathology*; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D007070:Immunoglobulin A; D009418:S100 Proteins; D000515:alpha 1-Antitrypsin; D000681:Amylases; D009113:Muramidase