title: Age-related prevalence of platelet-associated immunoglobulins G in nonthrombocytopenic patients with autoimmune thyroid disease and autoimmune polyglandular syndrome.
abstract: OBJECTIVE
  The prevalence of platelet-associated IgG (paIgG) in nonthrombocytopenic patients with autoimmune thyroid disease (AITD) alone or associated with autoimmune polyglandular syndrome (APS) has been studied.
  
  
  METHODS
  A total of 164 individuals were enrolled in this study: 81 patients with AITD alone, 33 patients with APS, and 50 healthy controls.
  
  
  RESULTS
  The presence of paIgG was recorded in 41 of 81 patients with AITD (51%) as compared with 2 of 50 control subjects (4%, p < 0.0001). The prevalence of paIgG in patients with APS was higher even when compared with patients with AITD alone (25/33, 76%; p = 0.02). The presence of paIgG was not related to the functional thyroid parameters. The prevalence of paIgG was higher in the older than in the younger patients (75 vs. 47%, p = 0.0037).
  
  
  CONCLUSIONS
  The results indicate that the prevalence of paIgG in patients with AITD is higher than previously thought, namely in elderly patients and in patients with APS, and not related to the thyroid function.
authors.affiliation: First Chair of Endocrinology, Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Gargano
authors.forename: D
authors.initials: D
authors.lastname: Mentuccia
authors.forename: L
authors.initials: L
authors.lastname: Conti
authors.forename: N
authors.initials: N
authors.lastname: Viceconti
authors.forename: R
authors.initials: R
authors.lastname: Sibilla
authors.forename: D
authors.initials: D
authors.lastname: Danese
authors.forename: F S
authors.initials: FS
authors.lastname: Celi
authors.forename: G
authors.initials: G
authors.lastname: Gandolfo
authors.forename: M
authors.initials: M
authors.lastname: Centanni
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000375:Aging / Q000097:blood*; D001327:Autoimmune Diseases / Q000150:complications / Q000453:epidemiology / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications / Q000378:metabolism*; D015995:Prevalence; D012016:Reference Values; D013959:Thyroid Diseases / Q000150:complications / Q000453:epidemiology / Q000378:metabolism*
chemical_list: D007074:Immunoglobulin G