Functional upper airway obstruction in a child with Freeman-Sheldon syndrome.
Freeman-Sheldon syndrome is defined as a combination of microstomia, deep set eyes, small palpebral fissures, arthrogryposis with ulnar deviation of the hand, talipes equinovarus and generalized muscular hypertension. Respiratory and swallowing problems are frequently encountered in these patients due to small orifices of mouth and nose. Obstruction of the upper airway tract resulting in tracheostomy has only been described twice. The described child manifested the typical dysmorphic features of Freeman-Sheldon syndrome and suffered from serious respiratory distress and swallowing difficulties from birth. The boy died at the age of 7 months after accidental decannulation of the tracheostoma during sleep. He did not show anatomical or histopathological abnormalities in the pharyngeal, laryngeal or tracheal regions. We assume that the only explanation of the repeated obstructive episodes is a functional muscular obstruction.
Schefels
Joerg
J
Neonatologische Intensivmedizin, Kinderklinik, Aachen, Deutschland.
Wenzl
Tobias G
TG
Merz
Ulrich
U
Ramaekers
Vincent
V
Holzki
Josef
J
Rudnik-Schoeneborn
Sabine
S
Hermanns
Benita
B
Hörnchen
Helmut
H
D000015:Abnormalities, Multiple; D000402:Airway Obstruction / Q000209:etiology* / Q000601:surgery*; D003025:Clubfoot; D017809:Fatal Outcome; D005385:Fingers / Q000002:abnormalities; D006801:Humans; D007223:Infant; D008297:Male; D008865:Microstomia / Q000150:complications*; D009333:Neck / Q000002:abnormalities; D063173:Retrognathia / Q000150:complications*; D013577:Syndrome; D014139:Tracheostomy / Q000295:instrumentation / Q000379:methods