title: [Role of alcohol in heroin overdose].
abstract: The relationship between ethanol and risk of heroin overdosage was studied. Statistical processing of the results of forensic chemical analysis (460 expert evaluations) carried out in Chelyabinsk Regional Bureau of Forensic Medical Expert Evaluations in 2000 was carried out. The results of morphine and ethanol measurements in the blood and urine from corpses where deaths ensued from narcotic or ethanol poisoning, were analyzed. The concentrations of morphine in the blood and urine were measured on a gaseous chromatographer with mass-selective detector (Hewlett Packard HP 6890/HP-5972). Methods for measuring urinary and blood morphine are described. The results of statistical analysis demonstrated relationships between the age and ethanol concentrations in the blood and urine; blood ethanol and total urinary and blood morphine concentrations; blood concentration of free morphine and presence of 6-monoacetylmorphine in the blood. The authors conclude that the presence of ethanol in the blood together with morphine drastically augments the risk of rapid death from respiration arrest. It can also lead to a relatively high risk of overdosage in experienced narcomaniacs using heroin and ethanol.
authors.forename: A B
authors.initials: AB
authors.lastname: Melent'ev
authors.forename: P I
authors.initials: PI
authors.lastname: Novikov
mesh_terms: D000428:Alcohol Drinking; D062787:Drug Overdose; D000431:Ethanol / Q000097:blood / Q000652:urine; D005554:Forensic Medicine; D008401:Gas Chromatography-Mass Spectrometry; D003932:Heroin / Q000009:adverse effects*; D006801:Humans; D012426:Russia
chemical_list: D000431:Ethanol; D003932:Heroin