The promise of retinoids to fight against cancer.
Retinoids have a reputation for being both detrimental and beneficial: they are teratogens, but they also have tumour-suppressive capacity. Cell biology and genetics have significantly improved our understanding of the mechanisms that underlie the anti-proliferative action of retinoids. Recent elucidation of the pathways that are activated by retinoids will help us to exploit the beneficial aspects of this powerful class of compounds for cancer therapy and prevention.
Altucci
L
L
Dipartimento di Patologia Generale e Oncologia, Seconda Università degli Studi di Napoli, Italy. lucia.altucci@unina2.it
Gronemeyer
H
H
D016588:Anticarcinogenic Agents / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D019281:Dimerization; D005544:Forecasting; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000235:genetics; D008954:Models, Biological; D009024:Morphogenesis / Q000187:drug effects; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000517:prevention & control; D015514:Oncogene Proteins, Fusion / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D020239:Receptor Cross-Talk; D018168:Receptors, Retinoic Acid / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D012176:Retinoids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000235:genetics / Q000517:prevention & control; D013329:Structure-Activity Relationship; D018808:Transcription Factor AP-1 / Q000037:antagonists & inhibitors; D015533:Transcriptional Activation / Q000187:drug effects; D014801:Vitamin A / Q000493:pharmacokinetics / Q000502:physiology
D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; D018168:Receptors, Retinoic Acid; D012176:Retinoids; D018808:Transcription Factor AP-1; C093476:promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; D014801:Vitamin A