title: Increased chemokine receptor expression and the infiltration of lymphoid organs.
abstract: Lymphocyte passage across endothelium into lymph nodes and Peyer's patches is a multistep process that involves selectin-supported rolling, followed by a triggering event, and then firm integrin-mediated adhesion. The combined actions of adhesion molecules and chemokines largely determine the migratory behavior of lymphocytes. Chemokines are known to mediate their effects through 7 transmembrane-domain G-protein-coupled receptors. Here, we review the role of chemokines and their receptors in lymphocyte's migration into lymphoid organs.
authors.affiliation: First Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Japan. hitoshih@m.ehime-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Hasegawa
mesh_terms: D002465:Cell Movement; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology; D008214:Lymphocytes / Q000502:physiology*; D008221:Lymphoid Tissue / Q000473:pathology*; D019707:Receptors, Chemokine / Q000502:physiology*
chemical_list: D019707:Receptors, Chemokine