title: Medium-sized arterial vasculitis associated with vascular deposits of immunoglobin E. Favorable response to intravenous methylprednisolone and cyclophosphamide.
abstract: Herein we describe the case of a female patient with medium-sized arterial vasculitis associated with high serum immunoglobin E (lgE) levels in the absence of eosinophilia. During occlusive vascular events, IgE deposits in the arterial muscle layer were demonstrated by immunohistochemistry, suggesting a pathogenic role of this antibody in blood vessel inflammation. Combined treatment with methylprednisolone and cyclophosphamide was successful in reducing serum IgE levels and IgE tissue deposits and in inducing the clinical manifestations of vasculitis into remission. This primary medium-sized IgE-associated vasculitis may constitute a new syndrome not previously reported.
authors.affiliation: Departamento de Patología Experimental, CINVESTAV del IPN, Ticomán y Av. Instituto Politécnico Nacional, Col. San Pedro Zacatenco, 07360 México City, D.F., México. lavallemontalvo@aol.com
authors.forename: Carlos
authors.initials: C
authors.lastname: Lavalle
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Santos-Argumedo
authors.forename: Angeles
authors.initials: A
authors.lastname: Hernández-Cueto
authors.forename: Rosendo
authors.initials: R
authors.lastname: Luría-Pérez
authors.forename: César
authors.initials: C
authors.lastname: González-Bonilla
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001158:Arteries / Q000276:immunology / Q000473:pathology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use*; D008800:Mexico; D014657:Vasculitis / Q000188:drug therapy* / Q000276:immunology*
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D007166:Immunosuppressive Agents; D007073:Immunoglobulin E; D003520:Cyclophosphamide; D008775:Methylprednisolone