1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy.
1H MRS imaging (MRSI) was performed on 15 patients with MRI-negative temporal lobe epilepsy (TLE) who underwent seizure surgery. The non-seizure-free patients (NSF) ipsilateral hippocampal N-acetylaspartate (NAA)/(Cr+Cho) z scores were lower than the contralateral scores (p = 0.04), and the NSF ipsilateral z scores were lower than the seizure-free patients' (SF) ipsilateral z scores (p = 0.0049). Similarly, NSF contralateral scores were lower than contralateral SF (p = 0.02). These findings suggest NAA predicts the surgical outcome in patients with TLE without evidence of mesial temporal sclerosis on MRI.
Suhy
J
J
Department of Radiology, University of California, San Francisco 94143-0138, USA.
Laxer
K D
KD
Capizzano
A A
AA
Vermathen
P
P
Matson
G B
GB
Barbaro
N M
NM
Weiner
M W
MW
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism*; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011237:Predictive Value of Tests; D013223:Statistics as Topic; D013702:Temporal Lobe / Q000601:surgery*; D016896:Treatment Outcome
D015415:Biomarkers; D001224:Aspartic Acid; C000179:N-acetylaspartate