title: CYP2D6 polymorphisms and atypical antipsychotic weight gain.
abstract: Reports have linked atypical antipsychotics (AAPs) with weight gain. The polymorphic CYP2D6 involved in metabolism has been associated with medication morbidity. Eleven subjects receiving olanzapine were genotyped for CYP2D6 to examine the relationship between 2D6 and AAP weight gain. Using a linear regression, the dependent variable was percent change in body mass index (BMI). Genotype, dose and duration of treatment were independent. Genotype was significant (P<0.0097) for those with a *1/*3 or *4 genotype experiencing a larger percent BMI change than those with a *1/*1 genotype. This may be due to increased olanzapine concentrations leading to increased exposure, which may trigger AAP weight gain.
authors.affiliation: College of Pharmacy, University of Iowa, Iowa City, Iowa, USA. vicki-ellingrod@uiowa.edu
authors.forename: Vicki L
authors.initials: VL
authors.lastname: Ellingrod
authors.forename: Del
authors.initials: D
authors.lastname: Miller
authors.forename: Susan K
authors.initials: SK
authors.lastname: Schultz
authors.forename: Heidi
authors.initials: H
authors.lastname: Wehring
authors.forename: Stephan
authors.initials: S
authors.lastname: Arndt
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D012559:Schizophrenia / Q000188:drug therapy*; D015430:Weight Gain / Q000187:drug effects / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents; D019389:Cytochrome P-450 CYP2D6