Preparation and evaluation of 90 Y skin patches for therapy of superficial tumours in mice.
90Y, a beta emitting radionuclide, was immobilized in a bandage patch for possible application for the therapy of superficial maladies such as tumours and skin cancers. The aim was to prepare a radiation source that could deliver uniform dose within a short duration and avoid the inconveniences faced with the gamma sources used in teletherapy and brachytherapy. 90Y-ferric hydroxide macroaggregates were prepared, filtered and immobilized between two layers of gauze. When placed in saline, no radioactivity leached for 3 days, proving its safety for external application. Fibrosarcoma was induced in mice for checking the efficacy of 90Y patches. 90Y patches of various activities were prepared and applied on the tumours. The effect of time gap between inception and treatment of tumour, dose delivered and multiple application in fractionated doses was studied. In all the cases, tumour growth in the treated animals was considerably reduced in comparison with controls. It was concluded from the experiments that treatment should be started at the earliest stage possible, i.e. when the tumour is palpable. Delivery of dose from radioactive patches of approximately 90-100 MBq each, thrice at weekly intervals proved to be more effective for regression of tumour growth.
Mukherjee
A
A
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India.
Pandey
U
U
Sarma
H D
HD
Pillai
M R A
MR
Venkatesh
M
M
D000818:Animals; D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D004867:Equipment Design / Q000379:methods; D005240:Feasibility Studies; D005290:Ferric Compounds / Q000737:chemistry; D005354:Fibrosarcoma / Q000473:pathology / Q000532:radiotherapy*; D051379:Mice; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D015021:Yttrium Radioisotopes / Q000008:administration & dosage* / Q000737:chemistry
D005290:Ferric Compounds; D015021:Yttrium Radioisotopes; C021024:ferric hydroxide