ADAM-mediated shedding and adhesion: a vascular perspective.
Proteolytic conversion (shedding) of membrane-bound proteins to soluble forms is a novel regulatory mechanism mediated by enzymes called a disintegrin and metalloproteases (ADAMs). In this review, the potential importance of ADAMs in vascular physiology and disease, especially in relation to atherosclerosis, will be highlighted.
Herren
Barbara
B
Cardiovascular Research Division, Institute of Physiology, University of Zurich, CH-8057 Zurich, Switzerland.
D001161:Arteriosclerosis / Q000503:physiopathology*; D019483:Disintegrins / Q000502:physiology*; D006801:Humans; D008666:Metalloendopeptidases / Q000502:physiology*
D019483:Disintegrins; D008666:Metalloendopeptidases