title: Spectral and photophysical studies of inclusion complexes of 2-amino-4,6-dimethyl pyrimidine with beta-cyclodextrin.
abstract: The interaction of 2-amino-4,6-dimethyl pyrimidine (ADMP) with beta-cyclodextrin (beta-CD) has been studied by means of UV absorption, steady state and time resolved fluorescence techniques. Spectral characteristics, bandwidths and photophysical parameters indicating that ADMP experience two different environments in aqueous solutions: bulk water and 1:1 (ADMP:beta-CD) inclusion complexation. The size restriction of the upper rim of beta-CD partially include ADMP and prevent the possibility of formation of 1:2 complex. The effective polarity of the cyclodextrin cavity experienced by the induced ADMP is equivalent with the polarity of an 80:20 methanol-water mixture.
authors.affiliation: Chemnistry Department, Faculty of Education, Tanta University, Kafr El-Sheikh, Egypt. elkemary@yahoo.com
authors.forename: M A
authors.initials: MA
authors.lastname: El-Kemary
authors.forename: H S
authors.initials: HS
authors.lastname: El-Gezawy
authors.forename: H Y
authors.initials: HY
authors.lastname: El-Baradie
authors.forename: R M
authors.initials: RM
authors.lastname: Issa
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D006860:Hydrogen Bonding; D007700:Kinetics; D008956:Models, Chemical; D008958:Models, Molecular; D011485:Protein Binding; D011743:Pyrimidines / Q000737:chemistry*; D013053:Spectrophotometry / Q000379:methods*; D013696:Temperature; D013997:Time Factors; D014466:Ultraviolet Rays; D047392:beta-Cyclodextrins
chemical_list: C464526:2-amino-4,6-dimethyl pyrimidine; D003505:Cyclodextrins; D011743:Pyrimidines; D047392:beta-Cyclodextrins; C031215:betadex