title: A review of the consequences of fluid and electrolyte shifts in weightlessness.
abstract: This review describes the renal-endocrine mechanisms related to the early losses of fluid-electrolytes from the body during weightlessness as well as their contribution to longer term adaptation of fluid-electrolyte balance. The hypotheses presented were generated by a systematic analysis of body fluid and renal dynamics observed under conditions of actual and simulated spaceflight. These have increased our understanding of the effects of acute headward fluid shifts on renal excretion, the factors promoting excess sodium excretion and the regulation of extracellular fluid composition.
authors.affiliation: Biomedical Laboratories Branch, NASA-Johnson Space Center, Houston, TX 77058, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Leach
mesh_terms: D000222:Adaptation, Physiological; D000450:Aldosterone / Q000378:metabolism / Q000502:physiology; D018495:Fluid Shifts / Q000502:physiology*; D006801:Humans; D012084:Renin-Angiotensin System / Q000502:physiology; D013026:Space Flight; D014667:Vasopressins / Q000378:metabolism / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology*; D014893:Weightlessness; D018474:Weightlessness Simulation
chemical_list: D014667:Vasopressins; D000450:Aldosterone