title: Evaluation of topically applied enilconazole for the treatment of dermatophytosis in a Persian cattery.
abstract: Many Persian catteries have long-standing dermatophyte infections and are particularly difficult to treat. Enilconazole is a topical antifungal agent that has demonstrated good efficacy in recent studies. Twenty-two Persian cats naturally infected with Microsporum canis in a breeding cattery were treated with topical 0.2% enilconazole and monitored for 180 days. The treatments were repeated every 3 days for a total of eight applications. All the cats improved clinically and became culture negative by day 28. By day 180, four cats had developed clinical dermatophytosis and all cats had positive fungal cultures. In this study, topical 0.2% enilconazole was generally well tolerated but may have caused hypersalivation, idiopathic muscle weakness and slightly elevated serum alanine aminotransferase (ALT) concentrations. This study suggests that enilconazole may be used safely with little risk to the young, aged and gravid animals.
authors.affiliation: College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Rm c247, Knoxville, TN 37996, USA. khnilica@utk.edu
authors.forename: Keith A
authors.initials: KA
authors.lastname: Hnilica
authors.forename: Linda
authors.initials: L
authors.lastname: Medleau
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001947:Breeding; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D003881:Dermatomycoses / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008864:Microsporum / Q000302:isolation & purification*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; C017435:enilconazole