[Hibernation and stunning as manifestations of ischemic dysfunction of the myocardium].
Current information on hybernation and stunning which are the basis of myocardial dysfunction resulting from chronic ischemic heart disease and revascularization is provided. Myocardial stunning is an acute disturbance of a contractile function of ischemic myocardium at the moment of coronary circulation restoration done by various methods (coronary shunting, angioplasty, thrombolysis). Myocardial hybernation is a chronically developing foci of subnormal contractility in the region of stenotic artery. The difference between them is that stunning is a complex of structural and metabolic damages under the condition "ischemia-reperfusion" while hybernation is an adaptation of the myocardium to chronic ischemia by metabolism switching to anaerobic glycolysis. The study of pathophysiology and morphology of hybernating and stunned myocardium is necessary for developing methods of myocardium protection from ischemic damage.
Sokolova
R I
RI
Russian Cardiological Research and Practical Center, 121552, Moscow.
Zhdanov
V S
VS
D000818:Animals; D006801:Humans; D009200:Myocardial Contraction; D015428:Myocardial Reperfusion Injury / Q000150:complications* / Q000503:physiopathology; D017682:Myocardial Stunning / Q000209:etiology* / Q000503:physiopathology