Effects of aging on C57BL/6J mice: an electrophysiological and morphological study.
Presbycusis is a progressive hearing loss associated with aging that manifests as deafness linked to cochlear morphological degeneration. The effects of aging on the auditory system were studied in C57BL/6J mice using electrophysiological (brainstem auditory evoked potentials; BAEP) and morphological techniques. Cochleae of animals aged 1, 6, 9, 12, 15, 18, 21, or 24 months old were used for that purpose. The BAEP showed a progressive increase in latency and a reduction in amplitude. Morphological studies demonstrated total degeneration of the organ of Corti, which was replaced by a single epithelial layer. An affinity histochemistry study demonstrated minor modifications of glycoconjugates in the organ of Corti during the aging process.
Bartolomé
Maria Visitación
MV
Center of Cell Culture (CAI-UCM) and Department of Surgery II (ORL), Faculty of Medicine, University Complutense, Madrid, Spain.
del
Castillo Eduardo
CE
López
Lorena Maestre
LM
Carricondo
Francisco
F
Poch-Broto
Joaquin
J
Gil-Loyzaga
Pablo
P
D000375:Aging / Q000502:physiology*; D000818:Animals; D003051:Cochlea / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D006001:Glycoconjugates / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009925:Organ of Corti / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D011304:Presbycusis / Q000378:metabolism / Q000503:physiopathology*
D006001:Glycoconjugates