Dynamics of reverse cholesterol transport: protection against atherosclerosis.
This review considers the antiatherogenic function of high density lipoprotein (HDL) from the point of view of its dynamics within the sequential steps of reverse cholesterol transport (RCT). It is postulated that the efficiency of cholesterol flux through the RCT pathways is clinically more relevant than the HDL cholesterol concentration. The particular role of pre-beta(1)-HDL is reviewed drawing attention to the relationship between its concentration and the flux of cholesterol through the RCT system.
Sviridov
Dmitri
D
Baker Medical Research Institute, PO Box 6492, St. Kilda Rd. Central, Melbourne, Vic. 8008, Australia. dmitri.sviridov@baker.edu.au
Nestel
Paul
P
D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism* / Q000517:prevention & control*; D001692:Biological Transport; D008076:Cholesterol, HDL / Q000378:metabolism*; D006801:Humans; D011322:Primary Prevention; D012680:Sensitivity and Specificity
D008076:Cholesterol, HDL