title: Pharmacodynamics in the evaluation of drug regimens.
abstract: We believe, especially in an era of increasing antimicrobial resistance, that the integration of PK/PD models and stochastic techniques provides a powerful new tool to clinicians, researchers, and regulatory agencies alike. By using techniques such as these, we can begin to level the playing field so that PK/PD measures for therapeutic agents can be more accurately compared with greater certainty, and not be limited to discussions of susceptibility method variation or comparisons of MIC results.
authors.affiliation: Cognigen Corp., Buffalo, NY 14221-5831, USA.
authors.forename: Sujata M
authors.initials: SM
authors.lastname: Bhavnani
authors.forename: Paul G
authors.initials: PG
authors.lastname: Ambrose
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
mesh_terms: D019540:Area Under Curve; D004358:Drug Therapy; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods*; D010599:Pharmacokinetics; D010600:Pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects*