title: Nature of nontransferrin-bound iron.
abstract: Nontransferrin-bound iron is now recognized to exist by many workers. It is present in the serum of patients suffering from a wide range of disease states and may be induced by certain therapeutic treatments. The chemical nature of this iron pool is unknown but almost certainly it is a multicomponent pool including a considerable proportion of protein-bound iron. Methods are required to separate and quantify these different components. The biological properties of the individual isoforms need to be established; it is possible that some forms are relatively nontoxic, while others are highly toxic. This paper reviews what is known about the nature of nontransferrin-bound iron and describes the methods currently available to quantify this important serum component.
authors.affiliation: Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NN, UK. robert.hider@kcl.ac.uk
authors.forename: Robert C
authors.initials: RC
authors.lastname: Hider
mesh_terms: D019281:Dimerization; D006801:Humans; D007501:Iron / Q000032:analysis / Q000097:blood* / Q000737:chemistry*; D012709:Serum Albumin / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism
chemical_list: D012709:Serum Albumin; D014168:Transferrin; D007501:Iron