Liquid-phase combinatorial synthesis of aminobenzimidazoles.
Liquid-phase synthesis of 2-arylaminobenzimidazoles using soluble polymer support strategy is first described. The key step to benzimidazole skeleton is achieved in the presence of diisopropylcarbodimide (DICDI) and isothiocyanates. A mechanism study for one-pot cyclodesulfurization is also investigated on the support. A wide range of benzimidazole derivatives is synthesized in excellent yield and purity just by simple wash and precipitation.
Huang
Kuo-Ting
KT
Department of Chemistry, National Dong Hwa University, Shou-Feng, Hualien 974, Taiwan.
Sun
Chung-Ming
CM
D010129:4-Aminobenzoic Acid / Q000737:chemistry; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D002234:Carbodiimides / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D017879:Isothiocyanates / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008956:Models, Chemical; D015394:Molecular Structure; D011108:Polymers; D013455:Sulfur / Q000737:chemistry
D001562:Benzimidazoles; D002234:Carbodiimides; D017879:Isothiocyanates; D011108:Polymers; D013455:Sulfur; D010129:4-Aminobenzoic Acid