Gastroprotective activity of solidagenone on experimentally-induced gastric lesions in rats.
The gastroprotective effect of the labdane diterpene solidagenone was assessed on gastric ulcer in rats. The effect of a single oral dose of the compound was evaluated at 50, 100 and 200 mg kg(-1) in the following test systems: pylorus ligature (Shay), aspirin- and ethanol-induced gastric ulcers. In pylorus-ligated rats (Shay model), the ulcerative index decreased by 37% with solidagenone pre-treatment at the three assayed doses. The effect of a single oral dose of 50 mg kg(-1) solidagenone was comparable with ranitidine at the same concentration and similar to higher doses of the compound. A significant effect (P < 0.001) at 100 and 200 mg kg(-1) was observed in the aspirin-induced ulcer model. At both doses, reduction in the number of lesions was approximately 50% compared with controls. The effect was comparable with the reference compound ranitidine (50 mg kg(-1)). With the ethanol-induced gastric ulcers, the effect of solidagenone at 100 and 200 mg kg(-1) was similar to a single oral dose of 20 mg kg(-1) omeprazole with a 50% reduction of the mean number of lesions compared with controls. In acute toxicity tests on mice, intraperitoneal administration of solidagenone showed no toxicity at doses up to 600 mg kg(-1). This is the first report on the gastroprotective activity of a labdane diterpene.
Rodríguez
Jaime A
JA
Instituto de Biología Vegetal y Biotecnología, Universidad de Talca, Chile.
Bustamante
Carlos
C
Astudillo
Luis
L
Schmeda-Hirschmann
Guillermo
G
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001241:Aspirin / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005663:Furans / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D009281:Naphthalenes / Q000009:adverse effects / Q000627:therapeutic use*; D009853:Omeprazole / Q000627:therapeutic use; D011899:Ranitidine / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D005663:Furans; D009281:Naphthalenes; C406719:solidagenone; D011899:Ranitidine; D009853:Omeprazole; D001241:Aspirin