IPF-1 gene variation and the development of type 2 diabetes.
Insulin promotor factor-1 (IPF-1) is a gene critical for pancreatic development and insulin transcription. We genotyped U.S. Caucasians with (n = 217) and without (n = 176) Type 2 diabetes to determine if three previously identified variants (Cys18Arg, Asp76Asn, Arg197His) in the IPF-1 gene play a role in the development of Type 2 diabetes. The Cys18Arg and Arg197His variants were not present in any subjects. The Asp76Asn variant was found in one control subject (0.9%) and none of the diabetic subjects. Similarly, none of the variants were detected in African American subjects with (n = 78) and without (n = 82) Type 2 diabetes. In conclusion, these variants are rare or absent in U.S. Caucasians and African Americans and therefore, unlikely to play a significant role in the development of Type 2 diabetes in these populations.
Silver
Kristi
K
Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. ksilver@medicine.umaryland.edu
Shetty
Archana
A
D000328:Adult; D000368:Aged; D044383:Black People / Q000235:genetics; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004252:DNA Mutational Analysis; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D018398:Homeodomain Proteins; D006801:Humans; D008875:Middle Aged; D020125:Mutation, Missense; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D015534:Trans-Activators / Q000235:genetics*; D044465:White People / Q000235:genetics; D001741:Black or African American
D018398:Homeodomain Proteins; D015534:Trans-Activators; C084010:pancreatic and duodenal homeobox 1 protein; D004247:DNA