title: Cell senescence and cancer.
abstract: Historically, the senescent state has been associated with, and was named after, the cell-cycle arrest that occurs after cells have undergone an intrinsically defined number of divisions in vitro. More recently, however, it has been shown that extrinsic factors, including those encountered in normal tissue-culture environments, can prematurely induce an indistinguishable senescent phenotype. In this review, we discuss the pathways of cell senescence, the mechanisms involved and the role that these pathways have in regulating the initiation and progression of cancer.
authors.affiliation: Department of Biochemistry, University College London, UK.
authors.forename: N F
authors.initials: NF
authors.lastname: Mathon
authors.forename: A C
authors.initials: AC
authors.lastname: Lloyd
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D016922:Cellular Senescence / Q000502:physiology*; D004249:DNA Damage; D004261:DNA Replication; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008957:Models, Genetic; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D010641:Phenotype; D012313:RNA / Q000235:genetics; D019098:Telomerase / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D016615:Telomere / Q000648:ultrastructure
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D009363:Neoplasm Proteins; C422952:telomerase RNA; D012313:RNA; D019098:Telomerase