Effects of tumors on inhaled pharmacologic drugs: II. Particle motion.
Computer simulations were conducted to describe drug particle motion in human lung bifurcations with tumors. The computations used FIDAP with a Cray T90 supercomputer. The objective was to better understand particle behavior as affected by particle characteristics, airflow conditions, and disease-modified airway geometries. The results indicated that increases in particle sizes, breathing intensities and tumor sizes could enhance drug deposition on the tumors. The modeling suggested that targeted drug delivery could be achieved by regulating breathing parameters and designing (selecting physical features of) aerosolized drugs. We present the theoretical work as a step towards improving aerosol therapy protocols. Since modeling describes factors affecting dose, it is complementary to considerations of the molecular aspects of drug formulation and pharmacokinetics.
Martonen
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National Health and Environmental Effects Research Laboratory, U S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. martonen.ted@epa.gov
Guan
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D000280:Administration, Inhalation; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D055592:Biophysical Phenomena; D001703:Biophysics; D003198:Computer Simulation; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D014867:Water
D000970:Antineoplastic Agents; D014867:Water