[Characteristics of aggressive and protective factors in erosive lesions of gastroduodenal mucosa].
OBJECTIVE
To investigate aggressive-protective factors in patients with erosive lesions of gastroduodenal mucosa.


METHODS
Intragastric pH-metry, tests for Helicobacter pylori, lysozyme activity, content of bile acid in gastric juice, components of gastric mucous gel were made in 106 patients.


RESULTS
It is shown that there are two alternative paths of erosions development in the gastroduodenal zone: infectious and non-infectious.


CONCLUSIONS
In patients infected with Helicobacter pylori, lowering of a protective ability of the mucous gel is caused by prevalence of synthesis of immature mucous components while in non-infected patients this happens as a result of high catabolism of mucous components.
Belova
E V
EV
Vakhrushev
Ia M
IaM
D000328:Adult; D001647:Bile Acids and Salts / Q000032:analysis; D004381:Duodenal Ulcer / Q000150:complications / Q000503:physiopathology; D004382:Duodenitis / Q000150:complications / Q000503:physiopathology*; D005750:Gastric Juice / Q000737:chemistry; D005753:Gastric Mucosa / Q000737:chemistry*; D005756:Gastritis / Q000150:complications / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000737:chemistry*; D008875:Middle Aged; D009093:Mucus / Q000737:chemistry; D009113:Muramidase / Q000032:analysis; D010437:Peptic Ulcer / Q000150:complications / Q000382:microbiology / Q000503:physiopathology*; D013276:Stomach Ulcer / Q000150:complications / Q000382:microbiology / Q000503:physiopathology
D001647:Bile Acids and Salts; D009113:Muramidase