title: Granulomatous and suppurative dermatitis at interferon alfa injection sites: report of 2 cases.
abstract: It has previously been reported that interferon alfa injection sites may develop pyoderma gangrenosum, interface dermatitis, vasculitis, or, more commonly, ulcers characterized by intravascular thrombi and a mixed inflammatory cell infiltrate. We describe 2 patients in whom granulomatous and suppurative dermatitis developed at interferon alfa injection sites. These cases extend the spectrum of interferon alfa injection site reactions. The histologic and clinical similarities of these cases with pyoderma gangrenosum and cutaneous Crohn's disease are explored.
authors.affiliation: Department of Dermatology, New York Hospital, NY, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Sanders
authors.forename: Klaus
authors.initials: K
authors.lastname: Busam
authors.forename: Steven R
authors.initials: SR
authors.lastname: Tahan
authors.forename: Richard A
authors.initials: RA
authors.lastname: Johnson
authors.forename: Dana
authors.initials: D
authors.lastname: Sachs
mesh_terms: D006099:Granuloma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007279:Injections, Subcutaneous / Q000009:adverse effects*; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000209:etiology*; D013492:Suppuration / Q000209:etiology
chemical_list: D016898:Interferon-alpha