The RNA polymerase II machinery: structure illuminates function.
Essential components of the eukaryotic transcription apparatus include RNA polymerase II, a common set of initiation factors, and a Mediator complex that transmits regulatory information to the enzyme. Insights into mechanisms of transcription have been gained by three-dimensional structures for many of these factors and their complexes, especially for yeast RNA polymerase II at atomic resolution.
Woychik
Nancy A
NA
Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Hampsey
Michael
M
D000818:Animals; D005656:Fungal Proteins / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D008954:Models, Biological; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D021122:Protein Subunits; D012319:RNA Polymerase II / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology*
D005656:Fungal Proteins; D046911:Macromolecular Substances; D021122:Protein Subunits; D014157:Transcription Factors; D012319:RNA Polymerase II