title: Drug eruptions and other adverse drug effects in aged skin.
abstract: The elderly are at higher risk for suffering the annoying and hazardous skin reactions that are associated with drug therapy. If a serious reaction occurs, the aged are also at higher risk for major morbidity and mortality compared with younger individuals. Early consideration of a drug cause and prompt cessation of all potentially associated drugs may improve a patient's outcome. Thus, a prompt, careful, and accurate characterization of a drug-related reaction is important in optimizing patient care, along with close monitoring for associated internal toxicities and other medical complications of severe cutaneous reactions.
authors.affiliation: Drug Safety Clinic, Department of Medicine, University of Toronto Medical School, Ontario, Canada.
authors.forename: John R
authors.initials: JR
authors.lastname: Sullivan
authors.forename: Neil H
authors.initials: NH
authors.lastname: Shear
mesh_terms: D000368:Aged; D003873:Dermatitis, Exfoliative / Q000139:chemically induced; D003875:Drug Eruptions / Q000145:classification / Q000175:diagnosis / Q000209:etiology; D005076:Exanthema / Q000139:chemically induced; D006801:Humans; D010787:Photosensitivity Disorders / Q000139:chemically induced; D011537:Pruritus / Q000139:chemically induced; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced; D014581:Urticaria / Q000139:chemically induced; D014657:Vasculitis / Q000139:chemically induced