title: Mutational analysis of the enterocin favorskii biosynthetic rearrangement.
abstract: [reaction: see text] A mutational analysis of the enterocin biosynthesis genes revealed that the putative oxygenase and the methyltransferase gene products EncM and EncK, respectively, jointly catalyze a biosynthetic Favorskii-like rearrangement. Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E-G is reported.
authors.affiliation: College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA.
authors.forename: Longkuan
authors.initials: L
authors.lastname: Xiang
authors.forename: John A
authors.initials: JA
authors.lastname: Kalaitzis
authors.forename: George
authors.initials: G
authors.lastname: Nilsen
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Bradley S
authors.initials: BS
authors.lastname: Moore
mesh_terms: D001952:Bridged-Ring Compounds / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D009154:Mutation; D019906:Nuclear Magnetic Resonance, Biomolecular; D013302:Streptomyces / Q000737:chemistry
chemical_list: D001952:Bridged-Ring Compounds; C012306:enterocin