title: Safety issues in scale-up of chemical processes.
abstract: Fast time-to-market is an important issue in the development of chemical processes for fine chemicals and drug production. However, this needs to be balanced against the equally important issue of process safety. Developing a safe process within a short time frame is a demanding challenge but advances in: (i) risk analysis methods; (ii) procurement and interpretation of safety and scale-up data; and (iii) process control have opened up new perspectives in this field. The thermal stability of chemicals during storage and transportation is another field of interest, and data obtained from research in this area should allow the simplification of certain tedious procedures.
authors.affiliation: Swiss Federal Institute of Technology, Department of Chemistry, Institute of Chemical Engineering, 1015 Lausanne, Switzerland. francis.stoessel@epfl.ch
authors.forename: F
authors.initials: F
authors.lastname: Stoessel
mesh_terms: D004345:Drug Industry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D011312:Pressure; D018570:Risk Assessment; D012449:Safety
chemical_list: D004364:Pharmaceutical Preparations