A goniolens for clinical monitoring of the mouse iridocorneal angle and optic nerve.
OBJECTIVE
Due to the increasing importance of mouse models and mouse genetics in ophthalmic research, we have developed a goniolens for mice.


METHODS
The size and basic design parameters of a human goniolens were adapted to the mouse eye.


RESULTS
The goniolens is straightforward to use and allows non-invasive visualization of the structures of the anterior chamber angle, including Schlemm's canal, trabecular meshwork, iris and anterior surface of the peripheral ciliary body. Goniophotography using the mouse lens allows documentation of anterior chamber angle abnormalities, and facilitates comparisons of changes to these structures in the same eye over time. In addition, high quality magnified views of the optic nerve, retinal vessels and posterior retina are easily obtained.


CONCLUSIONS
This goniolens is an important new tool for studying the genetic and clinical etiology of anterior segment dysgenesis and glaucoma in mice.
Smith
Richard S
RS
The Howard Hughes Medical Institute and The Jackson Laboratory, Bar Harbor, ME 04609, USA. rss@jax.org
Korb
Donald
D
John
Simon W M
SW
D000818:Animals; D000869:Anterior Eye Segment / Q000002:abnormalities; D002924:Ciliary Body / Q000033:anatomy & histology; D003315:Cornea / Q000033:anatomy & histology*; D004867:Equipment Design; D005124:Eye Abnormalities / Q000175:diagnosis; D005901:Glaucoma / Q000175:diagnosis; D006068:Gonioscopy / Q000295:instrumentation* / Q000379:methods; D007498:Iris / Q000033:anatomy & histology*; D007909:Lenses; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009900:Optic Nerve / Q000033:anatomy & histology*; D012160:Retina / Q000033:anatomy & histology; D012171:Retinal Vessels / Q000033:anatomy & histology; D014129:Trabecular Meshwork / Q000033:anatomy & histology*