title: [Diagnosis of holoprosencephalia. Report of 17 cases].
abstract: OBJECTIVE
  To establish the epidemiologic profile of holoprosencephalia and determine benefits of ultrasound and foetopathologic examination to the diagnostic. METHODS AN MATERIAL: [corrected] Retrospective study about 17 cases of holoprosencephalia observed in CMNT between Janaury 1992 and September 2000.
  
  
  RESULTS
  Ultrasound diagnosis was made in 13 cases (75%). Ultrasound criteria were; absence of median structure of the brain and unique ventricule. The prognosis was always bad. Foetopathologic examination revealed 7 cases of lobar holoproencephalia and 10 of semi lobar. Fascial dysmorphia were noted in 82% of cases.
  
  
  CONCLUSIONS
  The foetopathology and genetic counselling looking for fascial, dysmorphia in family's members gives a good evaluation of recurrences.
authors.affiliation: Centre de Maternité et de Néonatologie de Tunis.
authors.forename: S
authors.initials: S
authors.lastname: Siala Gaigi
authors.forename: A
authors.initials: A
authors.lastname: Masmoudi
authors.forename: M B
authors.initials: MB
authors.lastname: Chennoufi
authors.forename: S
authors.initials: S
authors.lastname: Jabnoun
authors.forename: B
authors.initials: B
authors.lastname: Ben Romdhane
authors.forename: M
authors.initials: M
authors.lastname: Chaabouni
authors.forename: A
authors.initials: A
authors.lastname: Mabrouk
authors.forename: K
authors.initials: K
authors.lastname: Neji
authors.forename: A
authors.initials: A
authors.lastname: Chabchoub
authors.forename: E
authors.initials: E
authors.lastname: Sfar
authors.forename: I
authors.initials: I
authors.lastname: Lebbi
authors.forename: F
authors.initials: F
authors.lastname: Zouari
authors.forename: H
authors.initials: H
authors.lastname: Chelli
authors.forename: H
authors.initials: H
authors.lastname: Rezigua
authors.forename: H
authors.initials: H
authors.lastname: Chaabouni
authors.forename: N
authors.initials: N
authors.lastname: Khrouf
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D005145:Face / Q000002:abnormalities; D005260:Female; D016142:Holoprosencephaly / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal