title: [Report on proton therapy according to good clinical practice at Hyogo Ion Beam Medical Center].
abstract: The Hyogo Ion Beam Medical Center(HIBMC) is a hospital-based charged particle treatment facility. Having two treatment ion beams(proton and carbon) and five treatment rooms, it is a pioneer among particle institutes worldwide. In May 2001, proton therapy was started as a clinical study for patients with localized cancer originating in the head and neck, lung, liver, and prostate. The aim of this study was to investigate the safety, effectiveness, and stability of the treatment units and systems based on the evaluation of acute toxicity, tumor response, and working ratio of the machine, respectively. Six patients, including liver cancer in three, prostate cancer in two, and lung cancer in one, were treated. There was no cessation of therapy owing to machine malfunction. Full courses of proton therapy consisting of 154 portals in all six patients were given exactly as scheduled. None of the patients experienced severe acute reactions of more than grade 3 according to NCI-CTC criteria. Tumor response one month post-treatment was evaluable in five of the six patients, and was CR in 1 (prostate cancer), PR in 2 (lung cancer: 1, liver cancer: 1), and NC in 2(liver cancer: 2). These results indicate that our treatment units and systems are safe and reliable enough for proton irradiation to be used for several malignant tumors localized in the body.
authors.affiliation: Department of Radiology, Hyogo Ion Beam Medical Center (HIBMC).
authors.forename: Masao
authors.initials: M
authors.lastname: Murakami
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Kagawa
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hishikawa
authors.forename: Mitsuyuki
authors.initials: M
authors.lastname: Abe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002173:Cancer Care Facilities; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000532:radiotherapy*; D061766:Proton Therapy; D011878:Radiotherapy / Q000295:instrumentation*; D016896:Treatment Outcome; D011522:Protons
chemical_list: D011522:Protons