Performance of USP calibrator tablets in flow-through cell apparatus.
USP dissolution calibrator tablets were analysed by the flow-through cell method with the intention of examining its applicability for the flow-through cell apparatus suitability test. Test was performed with Dissotest CE-6 apparatus, (Sotax, Switzerland) in flow-through cells for tablets and capsules: smaller cells of 12 mm diameter and larger ones of 22.6 mm diameter. Analyses were performed with laminar and turbulent flow of dissolution medium. The flow rates were 16 and 8 ml/min for laminar flow and only 16 ml/min for turbulent flow. From the results it can be concluded that both salicylic acid tablets and prednisone tablets could be used for apparatus suitability test also for the flow-through cell under the conditions of laminar flows of 16 and 8 ml/min in cells phi 12 and 22.6 mm. As regards the turbulent flow of 16 ml/min, without a holder, cells phi 12 mm could be used for salicylic acid tablets and both cells (phi 12 and 22.6 mm) for prednisone tablets.
Bielen
Neda
N
Smrecnikova 24, 8000, Novo mesto, Slovenia. xcom@infotehna.si
D002138:Calibration / Q000592:standards; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation / Q000379:methods / Q000592:standards; D011241:Prednisone / Q000032:analysis / Q000737:chemistry / Q000592:standards; D020156:Salicylic Acid / Q000032:analysis / Q000737:chemistry / Q000592:standards; D012995:Solubility; D013607:Tablets / Q000032:analysis* / Q000737:chemistry* / Q000592:standards
D013607:Tablets; D020156:Salicylic Acid; D011241:Prednisone