title: [Evolution of homocysteine during ovarian stimulation for IVF or ICSI].
abstract: OBJECTIVE
  To determine the homocysteine evolution during ovarian stimulation in IVF or ICSI protocols and in, a second time, to evaluate the role of hyperhomocysteine as thrombotic risk factor for the treated patients.
  
  
  METHODS
  Plasma homocysteine was determined three times for each of 31 women included in an IVF/ICSI program. Dosages were realised before stimulation, after gonadotrophin-releasing hormone agonist treatment (GnRH) and on the day of hCG injection. Vitamin B12 and folates were determined before stimulation. In case of hyperhomocysteinemia, a research of APCR (Activated Protein C Resistance) was realised.
  
  
  RESULTS
  Five hyperhomocysteinemia cases were discovered (16.12% of studied population). APCR was found in a patient with hyperhomocysteinemia (14 mumol/L, before stimulation). Molecular biology has confirmed an heterozygous mutation of factor V Leiden. During the ovarian stimulation the evolution of homocysteine was independent of the 17 beta oestradiol evolution.
  
  
  CONCLUSIONS
  The prevalence of hyperhomocysteinemia was not significative according to the limited size of the studied population. The increase of oestradiol during induction protocols is unrelated to the homocysteine level. This work must be continued with largest population to have better knowledge of the prevalence of hyperhomocysteinemia among women included in ovarian stimulation protocols.
authors.affiliation: Centre médicochirurgical et obstétrical (CMCO-SIHCUS), 19, rue Louis-Pasteur, 67300 Schiltigheim/Strasbourg, France. sihcus@evc.net
authors.forename: K
authors.initials: K
authors.lastname: Bettahar-Lebugle
authors.forename: O
authors.initials: O
authors.lastname: Feugeas
authors.forename: C
authors.initials: C
authors.lastname: Wittemer
authors.forename: J
authors.initials: J
authors.lastname: Ohl
authors.forename: C
authors.initials: C
authors.lastname: Rongières
authors.forename: I
authors.initials: I
authors.lastname: Nisand
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000819:agonists; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology; D010062:Ovulation Induction; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D006063:Chorionic Gonadotropin; D006710:Homocysteine; D007987:Gonadotropin-Releasing Hormone