title: [Splenic nodules and sickle cell anemia].
abstract: OBJECTIVE
  We report 4 patients with sickle cell anemia presenting with intra-splenic benign nodules corresponding to islands of preserved tissue within splenic ferro-calcinosis.
  
  
  METHODS
  Ultrasound, CT and MRI findings were evaluated and compared to a follow-up study by ultrasound and CT done after 6 to 12 months.
  
  
  RESULTS
  Ultrasound showed multiple well-defined rounded nodules appearing hypoechoic compared to the rest of the spleen that was hyperechoic. On CT, the nodules were homogenous, hypodense relative to the spleen, isodense to the liver in 3 cases and hypodense to the liver in 1 case. On MRI, the nodules appeared relatively hyperintense within low-signal-intensity spleens. The ultrasound and CT follow-up study demonstrated no remarkable change.
  
  
  CONCLUSIONS
  In sickle cell patients, intra-splenic benign nodules corresponding to normal splenic tissue may be identified on imaging studies. The differential diagnosis is discussed.
authors.affiliation: Département d'Imagerie Médicale, King Khalid Military City Hospital, P.O. Box 10018, Hafar Al Batin 31991 Arabie Saoudite.
authors.forename: S
authors.initials: S
authors.lastname: Jouini
authors.forename: S
authors.initials: S
authors.lastname: Sehili
authors.forename: A
authors.initials: A
authors.lastname: Mokrani
authors.forename: K
authors.initials: K
authors.lastname: Ayadi
authors.forename: Y
authors.initials: Y
authors.lastname: Fakunle
authors.forename: M H
authors.initials: MH
authors.lastname: Daghfous
authors.forename: M F
authors.initials: MF
authors.lastname: Ladeb
mesh_terms: D015746:Abdominal Pain / Q000175:diagnosis / Q000209:etiology; D000208:Acute Disease; D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013158:Splenic Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography