Influence of cytochrome P450 CYP2C9 genotypes in lung cancer risk.
Cytochrome P-450 CYP2C9 enzyme is involved in the metabolism of xenobiotics and carcinogens. Variant alleles CYP2C9*2 and CYP2C9*3 encode enzymes with altered properties, and CYP2C9*2 has been related to lung cancer risk. The frequency of CYP2C9 variant alleles was analyzed in genomic DNA from 104 patients with lung cancer and in 197 healthy controls. No statistically significant differences in CYP2C9 genotypes, allele frequencies or predicted phenotypes were observed between overall patients and controls. Unconditional logistic regression for the interaction smoking/genotype indicate P values of 0.66 and 0.62 for carriers of CYP2C9*2 and CYP2C9*3, respectively, versus individuals without these mutations. The P values for the same interaction in carriers of one and two mutated genes were 0.56 and 0.67, respectively, versus individuals homozygous for non-mutated genes. Independent analyses of histological types of lung cancer also indicated the absence of statistically significant differences as compared to healthy subjects. Association between CYP2C9 polymorphism and lung cancer risk was not identified in this study.
García-Martín
Elena
E
Department of Biochemistry, School of Biological Sciences, University of Extremadura, Avda. de Elvas s/n., Badajoz, Spain.
Martínez
Carmen
C
Ladero
José M
JM
Gamito
Francisco J G
FJ
Rodriguez-Lescure
Alvaro
A
Agúndez
José A G
JA
D000483:Alleles; D001189:Aryl Hydrocarbon Hydroxylases; D065729:Cytochrome P-450 CYP2C9; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000378:metabolism; D008297:Male; D009154:Mutation; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking; D039181:Steroid 16-alpha-Hydroxylase; D013250:Steroid Hydroxylases / Q000235:genetics*
D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases; D039181:Steroid 16-alpha-Hydroxylase