Long term behavior of lithographically prepared in vitro neuronal networks.
We measured the long term spontaneous electrical activity of neuronal networks with different sizes, grown on lithographically prepared substrates and recorded with multi-electrode-array technology. The time sequences of synchronized bursting events were used to characterize network dynamics. All networks exhibit scale-invariant Lévy distributions and long-range correlations. These observations suggest that different-size networks self-organize to adjust their activities over many time scales. As predictions of current models differ from our observations, this calls for revised models.
Segev
Ronen
R
School of Physics and Astronomy, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel.
Benveniste
Morris
M
Hulata
Eyal
E
Cohen
Netta
N
Palevski
Alexander
A
Kapon
Eli
E
Shapira
Yoash
Y
Ben-Jacob
Eshel
E
D004566:Electrodes; D008954:Models, Biological; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology