title: Granulocyte macrophage-colony stimulating factor and oral mucositis.
abstract: OBJECTIVE
  To evaluate the effect of granulocyte macrophage-colony stimulating factor (GM-CSF) in patients with oral mucositis.
  
  
  METHODS
  Literature was accessed through MEDLINE (1966-June 2000) and bibliographic searches.
  
  
  RESULTS
  Published literature assessing the use of GM-CSF to treat or prevent oral mucositis was analyzed.
  
  
  CONCLUSIONS
  Reports of GM-CSF improving mucositis have been published; however, because of limitations in these reports, insufficient evidence confirms the benefits of GM-CSF. These preliminary studies provide a rationale to conduct well-designed, double-blind, randomized trials to evaluate the safety and efficacy of GM-CSF in the treatment and/or prevention of oral mucositis induced by chemotherapy and/or radiotherapy.
authors.affiliation: Medical Affairs, Protein Design Labs, Inc., Fremont CA 94555-3617, USA. sfung@pdl.com
authors.forename: Stacey M
authors.initials: SM
authors.lastname: Fung
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Ferrill
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology / Q000627:therapeutic use*; D006801:Humans; D009061:Mouth Mucosa / Q000187:drug effects; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index; D013280:Stomatitis / Q000145:classification / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor