[Phenytoin poisoning caused by interaction with ticlopidine].
BACKGROUND
Drug interactions may cause diverse clinical symptoms.


METHODS
A case history.


RESULTS
A 58-year-old man was admitted to hospital with suspected stroke. It turned out that his neurological symptoms were caused by phenytoin intoxication. The patient had previously taken phenytoin for epilepsy for nine years without being intoxicated. Hospital records revealed that he had received ticlopidine for two weeks in connection with a coronary stent procedure five to seven weeks earlier. The probable cause of the phenytoin intoxication was interaction between ticlopidine and phenytoin.


CONCLUSIONS
This case history demonstrates that apparently unrelated drugs may interact and result in serious toxicity.
Dahm
Anders Erik Astrup
AE
Medisinsk divisjon, Ullevål universitetssykehus 0407 Oslo. adahm@chello.no
Brørs
Odd
O
D000927:Anticonvulsants / Q000097:blood / Q000506:poisoning*; D001927:Brain Diseases / Q000139:chemically induced*; D004347:Drug Interactions; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy; D005343:Fibrinolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000097:blood / Q000506:poisoning*; D013988:Ticlopidine / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D005343:Fibrinolytic Agents; D010672:Phenytoin; D013988:Ticlopidine