title: 2-Diazoindoles: building blocks for the synthesis of antineoplastic agents.
abstract: 2-Diazoindoles were prepared by diazotization of the corresponding 2-aminoindoles followed by neutralisation. 2-Diazoindoles were utilised for the synthesis of 2-triazenoindoles, indolo[2,1-d][1,2,3,5]tetrazines and indolo[2,1-c][1,2,4]triazines. Most of these compounds exhibited in vitro antiproliferative activity.
authors.affiliation: Dipartimento Farmacochimico, Tossicologico e Biologico dell'Università, Palermo, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Barraja
authors.forename: Patrizia
authors.initials: P
authors.lastname: Diana
authors.forename: Antonino
authors.initials: A
authors.lastname: Lauria
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Almerico
authors.forename: Gaetano
authors.initials: G
authors.lastname: Dattolo
authors.forename: Girolamo
authors.initials: G
authors.lastname: Cirrincione
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D004563:Electrochemistry; D007211:Indoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012997:Solvents; D013329:Structure-Activity Relationship; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D012997:Solvents