A cellular oscillator model for periodic pattern formation.
In this paper, we present a model for pattern formation in developing organisms that is based on cellular oscillators (CO). An oscillatory process within cells serves as a developmental clock whose period is tightly regulated by cell autonomous or non-autonomous mechanisms. A spatial pattern is generated as a result of an initial temporal ordering of the cell oscillators freezing into spatial order as the clocks slow down and stop at different times or phases in their cycles. We apply a CO model to vertebrate somitogenesis and show that we can reproduce the dynamics of periodic gene expression patterns observed in the pre-somitic mesoderm. We also show how varying somite lengths can be generated with the CO model. We then discuss the model in view of experimental evidence and its relevance to other instances of biological pattern formation, showing its versatility as a pattern generator.
Jaeger
J
J
Schumacher College, Totnes, Devon, UK. yoginho@usa.net
Goodwin
B C
BC
D000818:Animals; D000845:Annelida / Q000196:embryology; D001181:Arthropods / Q000196:embryology; D002468:Cell Physiological Phenomena; D003198:Computer Simulation; D015870:Gene Expression; D008648:Mesoderm / Q000502:physiology*; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology*; D010507:Periodicity; D014714:Vertebrates / Q000196:embryology*; D014981:Xenopus / Q000196:embryology