title: A 3,4-epoxypiperidine structure as a novel and simple DNA-cleavage unit.
abstract: Based on the 4-hydroxy-1-azabicyclo[3.1.0]hexane structure of azinomycin, a 3,4-epoxypiperidine structure was designed as a novel and simple alkylating molecular unit, and some 3,4-epoxypiperidine derivatives were found to show DNA-cleavage activity, the structural requirements for which were revealed.
authors.affiliation: Graduate School of Pharmaceutical Sciences Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Miyashita
authors.forename: Myunji
authors.initials: M
authors.lastname: Park
authors.forename: Sayako
authors.initials: S
authors.lastname: Adachi
authors.forename: Sayori
authors.initials: S
authors.lastname: Seki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
authors.forename: Takeshi
authors.initials: T
authors.lastname: Imanishi
mesh_terms: D000477:Alkylating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D004249:DNA Damage; D015195:Drug Design; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: C465229:3,4-epoxypiperidine; D000477:Alkylating Agents; D004852:Epoxy Compounds; D010880:Piperidines; D004247:DNA