Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria.
Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.
Newton
Paul N
PN
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
van Vugt
Michele
M
Teja-Isavadharm
Paktiya
P
Siriyanonda
Duangsuda
D
Rasameesoroj
Maneerat
M
Teerapong
Pramote
P
Ruangveerayuth
Ronatrai
R
Slight
Thra
T
Nosten
Francois
F
Suputtamongkol
Yupin
Y
Looareesuwan
Sornchai
S
White
Nicholas J
NJ
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D037621:Artemisinins; D000077332:Artesunate; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006207:Half-Life; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012717:Sesquiterpenes / Q000097:blood / Q000493:pharmacokinetics*; D013056:Spectrophotometry, Ultraviolet; D014744:Vietnam
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; D000077332:Artesunate; C039060:artenimol