title: Chemical constituents of Calophyllum brasiliensis: structure elucidation of seven new xanthones and their cancer chemopreventive activity.
abstract: The first study of chemical constituents of the stem bark of Calophyllum brasilienses collected in Brazil has led to the isolation and identification of seven new xanthones named brasixanthones A (1), B (4), C (5), D (6), E (2), F (3), and G (10), together with 10 known xanthones. Among the xanthones isolated in this study, 4, 5, 6, and 11 were found to exhibit significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.
authors.affiliation: Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ito
authors.forename: Masataka
authors.initials: M
authors.lastname: Itoigawa
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Mishina
authors.forename: Valdir Cechinel
authors.initials: VC
authors.lastname: Filho
authors.forename: Teruo
authors.initials: T
authors.lastname: Mukainaka
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
mesh_terms: D000956:Antigens, Viral / Q000187:drug effects; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D029759:Calophyllum / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D016393:Lymphoma, B-Cell; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044004:Xanthones
chemical_list: C421810:1,6-dihydroxy-6',6'-dimethylpyrano(2',3':2,3)-6'',6''-dimethylpyrano(2'',3'':7,8)xanthone; C452836:8-desooxygartanin; D000956:Antigens, Viral; D000998:Antiviral Agents; C033305:Epstein-Barr virus early antigen; D011714:Pyrans; D014966:Xanthenes; D044004:Xanthones; C452835:brasixanthone C; C452834:brasixanthone D; D013755:Tetradecanoylphorbol Acetate