The other half of Hebb: K+ channels and the regulation of neuronal excitability in the hippocampus.
Historically, much attention has focused on the mechanisms of activity-dependent plasticity since the description of long-term potentiation by Bliss and Lomo in the early 1970s, while extrasynaptic changes have received much less interest. However, recent work has concentrated on the role of back-propagating action potentials in hippocampal dendrites in synaptic plasticity. In this review, we focus on the modulation of back-propagating action potentials by K+ currents in the dendrites of hippocampal cells. We described the primary K+-channel subunits and their interacting subunits that most likely contribute to these currents, and how these sites can be regulated by phosphorylation and other mechanisms. In conclusion, we provide a model for an alternative form of coincidence detection through K+ channels in the hippocampus.
Schrader
Laura A
LA
Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Anderson
Anne E
AE
Varga
Andrew W
AW
Levy
Michael
M
Sweatt
J David
JD
D000200:Action Potentials; D000818:Animals; D003598:Cytoskeletal Proteins / Q000502:physiology; D003712:Dendrites / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D006801:Humans; D017136:Ion Transport; D020935:MAP Kinase Signaling System; D051379:Mice; D008958:Models, Molecular; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D010766:Phosphorylation; D011188:Potassium / Q000502:physiology*; D015221:Potassium Channels / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D024642:Potassium Channels, Voltage-Gated; D011494:Protein Kinases / Q000502:physiology; D011499:Protein Processing, Post-Translational; D021122:Protein Subunits; D051672:Shal Potassium Channels; D013569:Synapses / Q000502:physiology
D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; D015221:Potassium Channels; D024642:Potassium Channels, Voltage-Gated; D021122:Protein Subunits; D051672:Shal Potassium Channels; D011494:Protein Kinases; D011188:Potassium