title: Leiomyosarcoma of the sinonasal tract: a case report and literature review.
abstract: Leiomyosarcoma of the paranasal sinuses is uncommon and has an aggressive clinical behavior. Only 28 cases have been described in the literature, and, of these, only 3 patients treated with surgery had a disease-free survival. In this report, we describe the clinical history of a 57-year-old woman with a leiomyosarcoma of the paranasal sinuses successfully treated with a combination of surgery, radiation therapy, and chemotherapy. We obtained a total response with ifosfamide, doxorubicin, dacarbazine, and epirubicin. This case report emphasizes the possibility of treating this aggressive tumor with chemotherapy in accordance with the same therapy used in the treatment of uterine leiomyosarcomas.
authors.affiliation: ENT Department, "La Sapienza" University, Rome, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Fusconi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Magliulo
authors.forename: Carlo
authors.initials: C
authors.lastname: Della Rocca
authors.forename: Dario
authors.initials: D
authors.lastname: Marcotullio
authors.forename: Maria
authors.initials: M
authors.lastname: Suriano
authors.forename: Marco
authors.initials: M
authors.lastname: de Vincentiis
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001707:Biopsy, Needle; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome