[The effect of progestins on endometrial cancer in morphometric evaluation].
The morphometric estimation of the influence of the caproate 17-alfa-hydroxyprogesterone on the endometrial cancer was the aim this work. The quantitative evaluation of the reaction of neoplasmatic and some stromal cells such as fibroblast, fibrocytes, lymphocytes, macrophages was carried out. Every patient was given a high doses of the medicine before the operation. The comparison of the histological image and than morphometric estimation was done after operation. Examination was performed in three separate groups depending on the grading of the tumor. The result was the decreased number of the neoplasmatic cells in every group independently on the grading. In the fibroblasts and fibrocytes groups the increased number of cells especially in the G1 and G2 group was observed. In the group of lymphocytes and macrophages the increased number of all cells was observed in every group. On the basic of our results we assume that the application of the high doses of progestins decreased number of neoplasmatic cells and stimulates the cells of the monocyte-macrophage system.
Rozdolski
K
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II Katedry i Kliniki Ginekologii Akademii Medycznej we Wrocławiu.
D000077713:17 alpha-Hydroxyprogesterone Caproate; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000494:pharmacology*; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000008:administration & dosage / Q000494:pharmacology*; D007044:Hysterectomy; D007399:Interphase / Q000187:drug effects; D008875:Middle Aged; D017154:Stromal Cells / Q000187:drug effects; D013997:Time Factors; D014407:Tumor Cells, Cultured
D018931:Antineoplastic Agents, Hormonal; D006908:Hydroxyprogesterones; D000077713:17 alpha-Hydroxyprogesterone Caproate