title: First and unexpected synthesis of macrocyclic cyclophane-based unusual alpha-amino acid derivatives by phosphazene base without high dilution conditions.
abstract: First synthesis of a macrocylic cyclophane-based unusual alpha-amino acid derivative 11 by coupling of ethyl isocyanoacetate with 1,2-bis(4-bromomethylphenyl)ethane under phase-transfer catalysis (PTC) conditions. Phosphazene base such as 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine (BEMP) is useful to improve the yield of cyclophane derivative without high dilution conditions.
authors.affiliation: Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai 400 076, India. srk@chem.iitb.ac.in
authors.forename: Sambasivarao
authors.initials: S
authors.lastname: Kotha
authors.forename: Somnath
authors.initials: S
authors.lastname: Halder
authors.forename: Lakshminarasimhan
authors.initials: L
authors.lastname: Damodharan
authors.forename: Vasantha
authors.initials: V
authors.lastname: Pattabhi
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004988:Ethers, Cyclic / Q000737:chemistry*; D007201:Indicator Dilution Techniques; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry
chemical_list: D000596:Amino Acids; D004988:Ethers, Cyclic; D009943:Organophosphorus Compounds; D010455:Peptides