title: Design of Peumus boldus tablets by direct compression using a novel dry plant extract.
abstract: A solid pharmaceutical dosage formulation using a novel dry plant extract of Peumus boldus MOL. (Monimiaceae) (Pb) is proposed. The botanical evaluation of plant material, through morphological and anatomical diagnosis, is presented. This evaluation permits to identify the herb to be used correctly. The analysis of the most extractive solvent mixture and the attainment of plant extract (fluid and dry) are reported. Several formulations (tablets) containing a novel dry plant extract of Pb and common excipients for direct compression are evaluated. The following formulation: dry plant extract of Pb (170 mg), Avicel PH101 (112 mg), Lactose CD (112) and magnesium stearate (6 mg), compressed at 1000 mPa, showed the best pharmaceutical performance.
authors.affiliation: Departamento de Farmacia, Faculdad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria-5000, Córdoba, Argentina.
authors.forename: Santiago
authors.initials: S
authors.lastname: Palma
authors.forename: Claudia
authors.initials: C
authors.lastname: Luján
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Llabot
authors.forename: Gloria
authors.initials: G
authors.lastname: Barboza
authors.forename: Ruben Hilario
authors.initials: RH
authors.lastname: Manzo
authors.forename: Daniel Alberto
authors.initials: DA
authors.lastname: Allemandi
mesh_terms: D002626:Chemistry, Pharmaceutical; D019245:Compressive Strength; D006244:Hardness; D029585:Monimiaceae / Q000033:anatomy & histology* / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000033:anatomy & histology* / Q000737:chemistry*; D010946:Plants, Medicinal / Q000033:anatomy & histology / Q000737:chemistry; D011208:Powders; D012212:Rheology; D013607:Tablets
chemical_list: D010936:Plant Extracts; D011208:Powders; D013607:Tablets