Vertebrate limb development and possible clues to diversity in limb form.
Chick embryos are good models for vertebrate development. The principles that underlie chick wing development have been discovered and there is increasing knowledge about the molecules involved. The importance of identifying molecules is that this provides a direct link to understanding the genetic basis of diversity in form. Chick wing development will be compared with limb development in other vertebrates. Possible mechanisms that could lead to variations in form, including limb reductions and limblessness, differences between fore- and hindlimbs, limb proportions, and interdigital webbing can be suggested.
Tickle
Cheryll
C
Division of Cell & Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. c.a.tickle@dundee.ac.uk
D000818:Animals; D002450:Cell Communication; D002642:Chick Embryo; D005121:Extremities / Q000033:anatomy & histology / Q000196:embryology* / Q000254:growth & development; D005552:Forelimb / Q000033:anatomy & histology / Q000196:embryology* / Q000254:growth & development; D014644:Genetic Variation; D006614:Hindlimb / Q000033:anatomy & histology / Q000196:embryology* / Q000254:growth & development; D014921:Wings, Animal / Q000033:anatomy & histology / Q000196:embryology* / Q000254:growth & development