Subclinical central pontine myelinolysis following liver transplantation.
Central pontine myelinolysis (CPM) is a demyelinating disorder of unknown origin that almost exclusively affects the central portion of the basis pontis, and is one of the fatal neurological complications after liver transplantation. We describe two children with CPM detected incidentally after liver transplantation. To our knowledge, this is the first report of CPM diagnosed antemortem in children who had undergone liver transplantation. In our patients, there were no clinical manifestations associated with CPM. We conclude that, including silent cases such as our patients, CPM may be more prevalent than previously appreciated following liver transplantation.
Kato
Takeo
T
Department of Pediatrics, Faculty of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. takeo819@kuhp.kyoto-u.ac.jp
Hattori
Haruo
H
Nagato
Masako
M
Kiuchi
Tetsuya
T
Uemoto
Shinji
S
Nakahata
Tatsutoshi
T
Tanaka
Koichi
K
D000293:Adolescent; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007223:Infant; D016031:Liver Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D017590:Myelinolysis, Central Pontine / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D011149:Pons / Q000473:pathology; D012086:Reoperation