[Undecatungstophosphate sensitized strains of methicillin-resistant Staphylococcus aureus to beta-lactams].
Previously, a factor (Factor T) was found in aged mixtures of tungstate and phosphate, which greatly sensitizes strains of methicillin-resistant Staphylococcus aureus to beta-lactams. Factor T was purified and identified as undecatungstophosphate([PW11O39]7-). Undecatungstosilicate([SiW11O39]8-), a compound closely related to undecatungstophosphate, showed a similar enhancing effect. Chemically, these compounds are classified as "polyoxotungstates", and it is expected that these tungsten compounds will be useful as a "tool" in laboratory tests: i.e., in screening media for highly resistant MRSA strains. They may be also useful to investigate the resistant mechanism of the bacterial cells.
Tajima
Yutaka
Y
Clinical Laboratory, Saga Medical School Hospital, Saga 849-8501.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D016106:Methicillin Resistance; D017553:Phosphorus Compounds / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D017973:Tungsten Compounds / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D018440:beta-Lactam Resistance; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D017553:Phosphorus Compounds; D017973:Tungsten Compounds; D047090:beta-Lactams; C108976:undecaphosphotungstate