Bayesian QTL mapping using skewed Student-t distributions.
In most QTL mapping studies, phenotypes are assumed to follow normal distributions. Deviations from this assumption may lead to detection of false positive QTL. To improve the robustness of Bayesian QTL mapping methods, the normal distribution for residuals is replaced with a skewed Student-t distribution. The latter distribution is able to account for both heavy tails and skewness, and both components are each controlled by a single parameter. The Bayesian QTL mapping method using a skewed Student-t distribution is evaluated with simulated data sets under five different scenarios of residual error distributions and QTL effects.
von Rohr
Peter
P
Departments of Dairy Science and Statistics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0315, USA.
Hoeschele
Ina
I
D000465:Algorithms; D000483:Alleles; D001499:Bayes Theorem; D016009:Chi-Square Distribution; D002874:Chromosome Mapping / Q000379:methods*; D003198:Computer Simulation; D005838:Genotype; D006801:Humans; D007178:Inbreeding; D008390:Markov Chains; D008957:Models, Genetic; D009010:Monte Carlo Method; D010375:Pedigree; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D016008:Statistical Distributions