title: Poor prognosis associated with thrombocytosis in patients with gastric cancer.
abstract: BACKGROUND
  Thrombocytosis is commonly associated with malignant disease and has recently been suggested to be a poor prognostic indicator in patients with lung cancer and gynecological cancers. The prevalence of thrombocytosis in patients with gastric cancer was reviewed, and its association with poor prognosis was investigated.
  
  
  METHODS
  Platelet count (PLT) and hemoglobin concentrations (Hb) were reviewed in 369 consecutive patients with histologically verified gastric cancer from 1994 to 2000. Differences between categories were analyzed with analysis of variance, and survival was compared by using the log-rank test on the Kaplan-Meier life table. Multivariate Cox regression analysis was used to evaluate whether thrombocytosis is an independent prognostic marker.
  
  
  RESULTS
  Thrombocytosis was found in 42 patients, and anemia was found in 200 patients. PLT was negatively correlated with Hb. Mean PLT was significantly increased in patients with noncurative operations. There was a positive correlation between the depth of tumor invasion and PLT. One- and 3-year survival expectancies in patients with or without thrombocytosis were 52.4% and 23.4% and 85.7% and 72.9%, respectively. PLT was identified as an independent prognostic factor after lymph node metastasis and depth of tumor invasion.
  
  
  CONCLUSIONS
  Thrombocytosis is an independent prognostic indicator of survival in patients with gastric cancer.
authors.affiliation: Department of Surgery, Sakai Municipal Hospital, Sakai, Japan. mikeda@surg2.med.osaka-u.ac.jp
authors.forename: Masataka
authors.initials: M
authors.lastname: Ikeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imamura
authors.forename: Jyunzo
authors.initials: J
authors.lastname: Shimizu
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ishida
authors.forename: Seizo
authors.initials: S
authors.lastname: Masutani
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tatsuta
authors.forename: Takashi
authors.initials: T
authors.lastname: Satomi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012044:Regression Analysis; D013274:Stomach Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000401:mortality; D016019:Survival Analysis; D013922:Thrombocytosis / Q000453:epidemiology* / Q000209:etiology