[Relationship between expression of inducible nitric oxide synthase and of VEGF in oral carcinoma].
OBJECTIVE
To study the expression of inducible NOS in oral carcinoma and it's relationship with the expression of VEGF, MVD and lymphatic metastasis.


METHODS
With 9 cases of normal oral mucosa as control, the expression of iNOS in 41 cases of oral carcinoma was evaluated by immunohistochemistry SP staining. Meanwhile MVD and the expression of VEGF were also detected.


RESULTS
The expression rate of iNOS in 41 cases was 63.41%, and the rate between N+ group and N- group was significantly different (P < 0.01). There were significant difference of MVD (P < 0.001) and of the expression of VEGF(P < 0.05) among groups of different iNOS expression level.


CONCLUSIONS
The expression of iNOS in oral carcinomas is high, and it is closely related to angiogenesis and lymphatic metastasis. The expression of iNOS probably takes part in VEGF's angiogenic effect.
Zhao
S
S
Department of Stomatology, Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310009, China.
Liu
Y
Y
Ping
F
F
D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000378:metabolism*; D016228:Endothelial Growth Factors / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008222:Lymphokines / Q000032:analysis*; D009061:Mouth Mucosa / Q000201:enzymology; D009062:Mouth Neoplasms / Q000098:blood supply / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000032:analysis*; D052247:Nitric Oxide Synthase Type II; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II