[An inherited hemostatic disorder as the cause of menorrhagia].
Two women aged 39 and 30 years were investigated for possible coagulation disorders because of menorrhagia, anaemia and postoperative haemorrhages. These investigations revealed that they had type 1 Von Willebrand's disease. During the treatment with desmopressin, factor VIII and Von Willebrand factor (VWF) activity normalised. About one third of the patients referred to a gynaecologist for menorrhagia have an inherited bleeding disorder, of which type 1 Von Willebrand's disease is the most prevalent. Once a gynaecological cause of the menorrhagia has been excluded, or in the case of an increased risk on the basis of the medical history, a limited haemostatic investigation can establish or exclude an inherited coagulation disorder. For women with a coagulation disorder the menorrhagia can be treated. Surgical interventions can be carried out safely following treatment with desmopressin or factor VIII/VWF concentrates.
Leebeek
F W G
FW
Afd. Hematologie, Academisch Ziekenhuis Rotterdam-Dijkzigt, Dr. Molewaterplein 40, 3015 GD Rotterdam. leebeek@haed.azr.nl
Lotgering
F K
FK
D000328:Adult; D000740:Anemia / Q000209:etiology; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D005169:Factor VIII / Q000627:therapeutic use; D005260:Female; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008595:Menorrhagia / Q000209:etiology*; D019106:Postoperative Hemorrhage / Q000209:etiology; D014842:von Willebrand Diseases / Q000150:complications* / Q000188:drug therapy; D014841:von Willebrand Factor / Q000627:therapeutic use
D006490:Hemostatics; D014841:von Willebrand Factor; D005169:Factor VIII; D003894:Deamino Arginine Vasopressin
Een erfelijke hemostaseafwijking als oorzaak van menorragie.