[Quantitative determination of fenfluramine hydrochloride and its tablets by high performance liquid chromatography].
Fenfluramine hydrochloride and its tablets were determined with high performance liquid chromatography by using an analytical column (25 cm x 0.46 cm i.d.) packed with Hypersil BDS C18 (5 microns), a UV detector at 264 nm and V(acetonitrile): V(0.4 mol/L ammonium acetate): V(triethylamine) = 30:70:2 as eluent. The quantitative determination was performed with caffeine as the internal standard. The internal standard method showed good linearity in the mass concentration range of 0.1-0.5 g/L with r = 0.9999. The average recovery of fenfluramine tablets was 99.98%. This method is simple, rapid, sensitive and reproducible.
Qian
X
X
Dalian Institute for Drug Control, Dalian, 116021.
Zhao
Y
Y
Sun
L
L
D001067:Appetite Depressants / Q000032:analysis*; D002110:Caffeine / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D005277:Fenfluramine / Q000032:analysis*; D013607:Tablets
D001067:Appetite Depressants; D013607:Tablets; D005277:Fenfluramine; D002110:Caffeine