title: Primary duodenal adenocarcinoma associated with neurofibromatosis type 1.
abstract: It is well known that patients with neurofibromatosis have an increased incidence of various neoplasms, most of these being tumors of neural-crest origin, including neurofibromas, leiomyomas, ganglioneuromas, paragangliomas, and carcinoids. However, the occurrence of small-bowel adenocarcinoma is rare. In this article, we report a patient with small-bowel adenocarcinoma, the seventh such reported case. We include a review of the literature and a brief discussion of the implications of this association. We suggest that the association between small-bowel adenocarcinomas and neurofibromatosis may not be fortuitous, and that small-bowel adenocarcinoma should be considered, in particular. in the differential diagnosis of gastrointestinal symptoms in patients with neurofibromatosis. Also, a definite histologic diagnosis must be made, with the employment of special staining techniques, because of the differing prognoses for various cell types.
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Kwangju, Korea.
authors.forename: Young-Eun
authors.initials: YE
authors.lastname: Joo
authors.forename: Hyun-Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Sung-kyu
authors.initials: SK
authors.lastname: Choi
authors.forename: Jong-Sun
authors.initials: JS
authors.lastname: Rew
authors.forename: Chang-Soo
authors.initials: CS
authors.lastname: Park
authors.forename: Sei-Jong
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis*; D001706:Biopsy; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000379:methods; D004379:Duodenal Neoplasms / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000150:complications / Q000175:diagnosis*