title: Topical mitomycin as an adjunct to choanal atresia repair.
abstract: OBJECTIVE
  To evaluate the use of topical mitomycin in choanal atresia repair to reduce the development of granulation tissue and cicatrix.
  
  
  METHODS
  Retrospective case series in 2 tertiary care centers.
  
  
  METHODS
  Twenty patients with either unilateral or bilateral congenital choanal atresia underwent repair using the transnasal endoscopic approach, the transpalatal approach, or both.
  
  
  METHODS
  The surgeons favor the use of the endoscopic transnasal drillout technique for all unilateral cases of choanal atresia and for selected bilateral cases. We describe our experience and treatment paradigm for these 20 patients (15 with unilateral atresia, 5 with bilateral atresia). Topical application of mitomycin was used, and in some cases postoperative stenting, for a period of 1 to 2 weeks. In 8 cases, a second application of mitomycin was used. Follow-up ranged from 3 months to 2 years (mean, 9 months).
  
  
  METHODS
  The patency of the choanae without respiratory distress or nasal drainage, as assessed by endoscopic evaluation, determined a successful repair.
  
  
  RESULTS
  Of the 20 patients, 17 retained patent airways. Three patients experienced improvement from a total atresia to a narrowed, stenotic choana.
  
  
  CONCLUSIONS
  The use of mitomycin as an adjunct to the surgical repair of choanal atresia may offer improved patency with a decreased need for stenting, dilatations, and revision surgery. Newer endoscopic techniques with powered instrumentation further enhance the safety and efficacy in the repair of choanal atresia.
authors.affiliation: Department of Otorhinolaryngology, Cornell University Medical Center, Ithaca, NY, USA. mukeshprasad@post.harvard.edu
authors.forename: Mukesh
authors.initials: M
authors.lastname: Prasad
authors.forename: Robert F
authors.initials: RF
authors.lastname: Ward
authors.forename: Max M
authors.initials: MM
authors.lastname: April
authors.forename: John P
authors.initials: JP
authors.lastname: Bent
authors.forename: Patrick
authors.initials: P
authors.lastname: Froehlich
mesh_terms: D000287:Administration, Topical; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002754:Choanal Atresia / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use*; D012189:Retrospective Studies; D015607:Stents; D016896:Treatment Outcome
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D016685:Mitomycin