Gastroprotective and antiulcerogenic effects of Rumex patientia L. extract.
Gastroprotective and antiulcerogenic effects of the aqueous extract of Rumex patientia L. roots (D-1) were investigated in rats and compared to non-steroidal antiinflammatory drugs (NSAIDs). Whereas oral administration of high doses of NSAIDs caused stomach damage, D-1 (aqueous extract of Rumex patientia roots, 150 and 500 mg/kg) and nimesulid (100 and 300 mg/kg) did not cause any damage. In rats, the number of stress ulcers induced by the administration of 150 mg/kg of D-1 were identical to that of the control group. However, compared to the control group, the number of stress ulcers decreased 1.9 times and the size of ulceration areas decreased 1.1 times in the group treated with 500 mg/kg of D-1.
Süleyman
H
H
Department of Pharmacology Faculty of Medicine, Atatürk University, Erzurum.
Demirezer
L O
LO
Kuruüzüm-Uz
A
A
Akçay
F
F
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D019664:Polygonaceae / Q000737:chemistry*; D051381:Rats; D013270:Stomach / Q000473:pathology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications; D014421:Turkey
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents