Efficacy of oral terbinafine in feline dermatophytosis due to Microsporum canis.
Microsporum canis is the dermatophyte most commonly responsible for ringworm in cats. The purpose of this paper was to evaluate the in vivo efficacy of oral terbinafine (Lamisil; Sandoz) in the treatment of feline ringworm caused by M canis, and to consider this drug as an alternative to griseofulvin or imidazoles. Fifteen cats infected with M canis were treated orally once daily with 30 mg/kg of terbinafine over a 2-week period. All treated animals were checked for dermatophytes on the last day of treatment, a month later and 3 months after the last administration of the drug. Only 12 cats could be used in the whole trial and 11 of these (92%) showed a complete cure. Terbinafine could be an effective alternative to griseofulvin when fungal resistance or idiosyncrasic intolerance are shown and, compared with griseofulvin, could give a faster rate of cure and less relapses.
Mancianti
F
F
Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti, Università di Pisa, Viale delle Piagge, 2, 56124 Pisa, Italy.
Pedonese
F
F
Millanta
F
F
Guarnieri
L
L
D000284:Administration, Oral; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D003881:Dermatomycoses / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D006118:Griseofulvin / Q000627:therapeutic use; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008864:Microsporum; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D000077291:Terbinafine; D016896:Treatment Outcome
D000935:Antifungal Agents; D009281:Naphthalenes; D017964:Itraconazole; D006118:Griseofulvin; D000077291:Terbinafine