Chromatin remodeling: nucleosomes bulging at the seams.
ATP-dependent chromatin remodeling enzymes, such as SWI/SNF, hydrolyze thousands of ATPs to regulate gene expression on chromatin fibers. Recent mechanistic studies suggest that these enzymes generate localized changes in DNA topology that drive formation of multiple, remodeled nucleosomal states.
Peterson
Craig L
CL
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA. craig.peterson@umassmed.edu
D000255:Adenosine Triphosphate / Q000378:metabolism*; D002843:Chromatin / Q000502:physiology*; D004247:DNA / Q000378:metabolism; D004265:DNA Helicases; D006657:Histones / Q000378:metabolism; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism*; D009707:Nucleosomes; D014157:Transcription Factors / Q000378:metabolism*
D002843:Chromatin; D006657:Histones; D009687:Nuclear Proteins; D009707:Nucleosomes; D014157:Transcription Factors; D000255:Adenosine Triphosphate; D004247:DNA; C084108:SMARCA4 protein, human; D004265:DNA Helicases