The use of coagulation activation markers (soluble fibrin polymer, TpP, prothrombin fragment 1.2, thrombin-antithrombin, and D-dimer) in the assessment of hypercoagulability in patients with inherited and acquired prothrombotic disorders.
A total of 260 consecutive patients, referred for hypercoagulable assessment, was included in this study. Four coagulation activation markers were utilized to assess these patients [enzyme-linked immunosorbent assays for soluble fibrin polymer (TpP), prothrombin fragment 1.2, thrombin-antithrombin complex, and D-dimer]. The mean levels of the activation markers directly correlated with the number of hypercoagulable abnormalities. The percentage of patients with increased TpP levels for each group was lower than the other activation markers. The findings indicate that activation markers reflect the number of underlying thrombophilic abnormalities. Our data suggest that there is a utility in performing a panel of coagulation activation markers to assess the thrombotic risk. The measurement of soluble fibrin polymer may be more reflective of an impending vascular event.
Arkel
Y S
YS
Maternal &Fetal Medicine Division, Department of OB/Gyn, NYU Medical Center, New York, New York 10016, USA. dehui.ku@med.nyu.edu
Paidas
M J
MJ
Ku
D H
DH
D020016:Activated Protein C Resistance / Q000097:blood / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016736:Antiphospholipid Syndrome / Q000097:blood; D000990:Antithrombin III; D020152:Antithrombin III Deficiency / Q000097:blood; D001327:Autoimmune Diseases / Q000097:blood; D015415:Biomarkers; D004797:Enzyme-Linked Immunosorbent Assay; D005165:Factor V / Q000235:genetics; D005260:Female; D005337:Fibrin / Q000032:analysis*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D010447:Peptide Hydrolases / Q000097:blood*; D020151:Protein C Deficiency / Q000097:blood; D018455:Protein S Deficiency / Q000097:blood; D011516:Prothrombin / Q000235:genetics; D012306:Risk; D012995:Solubility; D019851:Thrombophilia / Q000097:blood* / Q000209:etiology / Q000235:genetics
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; C046193:antithrombin III-protease complex; C095381:factor V Leiden; C036309:fibrin fragment D; C045879:prothrombin fragment 1.2; C465961:thrombus precursor protein, human; D000990:Antithrombin III; D005165:Factor V; D011516:Prothrombin; D005337:Fibrin; D010447:Peptide Hydrolases