Haplotypes of the beta-globin gene as prognostic factors in sickle-cell disease.
We collaborated with researchers from Egypt, Syrian Arab Republic and Jordan in a study of patients with sickle-cell disease from those countries, and from various parts of Saudi Arabia, in order to investigate the influence of genetics on the clinical presentation of the disease, and to attempt to determine the origin of the sickle-cell gene in Arabs. Our results suggest that beta-globin gene haplotypes influence the clinical presentation of sickle-cell disease, and that there are at least two major foci for the origin of the sickle-cell gene, one in the eastern part of Saudi Arabia, and the other in the populations of North Africa and the north-western part of the Arabian peninsula.
el-Hazmi
M A
MA
Medical Biochemistry Department, World Health Organization Collaborating Centre for Haemoglobinopathies, Thalassaemias and Enzymopathies, College of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia.
Warsy
A S
AS
Bashir
N
N
Beshlawi
A
A
Hussain
I R
IR
Temtamy
S
S
Qubaili
F
F
D000755:Anemia, Sickle Cell / Q000145:classification / Q000453:epidemiology* / Q000235:genetics*; D004534:Egypt / Q000453:epidemiology; D005787:Gene Frequency; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics; D005914:Globins / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D007597:Jordan / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics; D011159:Population Surveillance; D011379:Prognosis; D012111:Residence Characteristics / Q000706:statistics & numerical data; D015183:Restriction Mapping; D012529:Saudi Arabia / Q000453:epidemiology; D012720:Severity of Illness Index; D013593:Syria / Q000453:epidemiology
D005914:Globins