Dietary fat and salivary prostaglandin E2.
A study of the relation between dietary fat intake and salivary prostaglandin E2 was undertaken in Transkei, South Africa. Samples of saliva were obtained from (1) Transkeians on a very low fat diet, (2) Transkeians on a low fat diet, (3) Transkeians on a medium fat diet, (4) British patients. Salivary PGE2 means for the groups were (1) 2357 pg/ml, (2) 2020 pg/ml, (3) 733 pg/ml, (4) 312.5 pg/ml. Differences between groups 1 and 3, 1 and 4, and 2 and 4 were significant. Rural Transkeians on a low-fat diet have an elevated level of PGE2 in saliva. As fat increases in the diet, PGE2 in saliva tends towards the level found in those who eat a western diet. An increase in the level of PGE2 production in the upper gastrointestinal tract and in the tissues of the body may be a factor in promoting cancer of the esophagus and diseases favored by Th1 immune dysfunction.
Sammon
Alastair M
AM
Department of Surgery, University of Bristol, Bristol Royal Infirmary, United Kingdom. alastair.sammon@doctors.org.uk
Morgan
Anthony
A
D044383:Black People; D004041:Dietary Fats / Q000494:pharmacology*; D015232:Dinoprostone / Q000096:biosynthesis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D012463:Saliva / Q000187:drug effects* / Q000378:metabolism*; D013019:South Africa; D044465:White People
D004041:Dietary Fats; D015232:Dinoprostone