Frequency encoding of intracellular Ca2+ signals.
In a very recent theoretical study, we showed that simple mitochondrial kinetics, originally proposed by Marhl et al., could be easily used as a plug-in element in other models describing intracellular Ca2+ dynamics. We analysed several previously published models and showed that mitochondria could indeed maintain the constant amplitude of intracellular Ca2+ oscillations very effectively. We also pointed out the importance of amplitude regulation for the frequency encoding of intracellular Ca2+ signals. This paper focuses on giving a more exhaustive demonstration of this phenomenon of frequency encoding for the model of Dupont et al.
Grubelnik
Vladimir
V
Department of Physics, Faculty of Education, University of Maribor, Koroska cesta 160, SI-2000 Maribor, Slovenia.
Marhl
Marko
M
D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D007700:Kinetics; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D013997:Time Factors
D002118:Calcium