title: Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism.
abstract: We describe the ANCA profile of two monozygotic triplets (A and B) treated with propylthiouracil (PTU) for hyperthyroidism who developed LE-like manifestations. Triplet C also developed hyperthyroidism but was not treated with PTU and never experienced LE-like symptoms. Triplet A and B showed a marked rise in P-ANCA titer to 1:1280 after PTU was introduced whereas triplet C never had a titer higher than 1:80. Consecutive sera were investigated for ANCA to six different neutrophil granule proteins. Triplet A and B, but not C, both developed a strongly positive elastase-ANCA. Our results confirm the importance of a genetic factor influencing the susceptibility to drug-induced LE.
authors.affiliation: Department of Pediatrics, Skejby Sygehus, Aarhus University Hospital, Denmark. t.herlin@dadlnet.dk
authors.forename: Troels
authors.initials: T
authors.lastname: Herlin
authors.forename: Niels H
authors.initials: NH
authors.lastname: Birkebaek
authors.forename: Ole D
authors.initials: OD
authors.lastname: Wolthers
authors.forename: Niels H H
authors.initials: NH
authors.lastname: Heegaard
authors.forename: Allan
authors.initials: A
authors.lastname: Wiik
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D013956:Antithyroid Agents / Q000009:adverse effects*; D002648:Child; D006650:Histocompatibility Testing; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000139:chemically induced*; D011441:Propylthiouracil / Q000009:adverse effects*; D014310:Triplets
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D011441:Propylthiouracil