Novel potent antagonists of human neuropeptide Y Y5 receptor. Part 1: 2-oxobenzothiazolin-3-acetic acid derivatives.
Novel NPY-Y5 antagonist FR73966 was discovered by screening of our in-house chemical library. The analogues were prepared by application of parallel synthesis techniques. Some of the resulting 2-oxobenzothiazolin-3-acetic acid derivatives exhibited nanomolar binding affinity for human NPY-Y5 receptors.
Tabuchi
Seiichiro
S
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 2-1-6, Kashima, Yodogawa-ku, 532-8514, Osaka, Japan.
Itani
Hiromichi
H
Sakata
Yoshihiko
Y
Oohashi
Hiroko
H
Satoh
Yoshinari
Y
D006801:Humans; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors*; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology*
C465745:2-oxobenzothiazolin-3-acetic acid; D017476:Receptors, Neuropeptide Y; D013844:Thiazoles; C100568:neuropeptide Y5 receptor