A general method for the preparation of 4- and 6-azaindoles.
Nitropyridines reacted with an excess of vinyl Grignard reagent to produce 4- or 6-azaindoles. Improved yields were obtained when a halogen atom was present at the position alpha to the nitrogen atom in the pyridine ring.
Zhang
Zhongxing
Z
Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA. wangta@bms.com
Yang
Zhong
Z
Meanwell
Nicholas A
NA
Kadow
John F
JF
Wang
Tao
T