Structural surprises from the flaviviruses and alphaviruses.
Recent structural studies demonstrate that the alphavirus and flavivirus fusion proteins, although very similar in overall fold, are arranged very differently in the two virions. These differences raise many interesting questions about virus assembly and fusion activity.
Kielian
Margaret
M
Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
D000524:Alphavirus / Q000737:chemistry* / Q000378:metabolism; D020285:Cryoelectron Microscopy; D018067:Flaviviridae / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D014760:Viral Fusion Proteins / Q000737:chemistry* / Q000378:metabolism
D014760:Viral Fusion Proteins