Scytonemin--a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases.
Stevenson
C S
CS
University of California Santa Barbara, Department of Ecology, Evolution, and Marine Biology, 93106, USA. Christopher.S.Stevenson@gsk.com
Capper
E A
EA
Roshak
A K
AK
Marquez
B
B
Grace
K
K
Gerwick
W H
WH
Jacobs
R S
RS
Marshall
L A
LA
D000818:Animals; D018797:Cell Cycle Proteins; D002455:Cell Division / Q000187:drug effects; D000458:Cyanobacteria / Q000737:chemistry; D004730:Endothelium, Vascular / Q000166:cytology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000494:pharmacology* / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology*; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D010636:Phenols / Q000494:pharmacology* / Q000627:therapeutic use; D010860:Pigments, Biological; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D064546:Protein Kinase C beta; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D011994:Recombinant Proteins; D014471:Umbilical Veins; D000097869:Polo-Like Kinase 1
D018797:Cell Cycle Proteins; D004791:Enzyme Inhibitors; D007211:Indoles; D007527:Isoenzymes; D010636:Phenols; D010860:Pigments, Biological; D011493:Protein Kinase C; D064546:Protein Kinase C beta; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D011994:Recombinant Proteins; D000097869:Polo-Like Kinase 1; C083368:scytonemin