[Preformulation study of a potential local anesthetic from a group of phenylcarbamic acid derivatives].
Within pre-formulation studies of phenylcarbamic acid derivatives with local anaesthetic effects, potential drug IV with the chemical name N-(2-(2-ethylphenylcarbamoyloxy)-ethyl)-piperidiniumchloride was examined. The study evaluated the effect of polyhydric alcohols--glycerol, propylene glycol, sorbitol and their concentrations of 5; 10; 15, and 20 wt % on the values of the partition coefficient in the system n-octanol/water, surface tension, and viscosity of the solutions of potential drug IV. The optimal auxiliary substance seems to be glycerol of a concentration of 15-20 wt %, as it does not affect the values of the partition coefficient and surface tension of potential drug IV solutions in a statistically significant manner.
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lekarnakytlicka@lloydspharmacy.cz
D000779:Anesthetics, Local / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical
D000779:Anesthetics, Local; D002219:Carbamates; C059692:phenylcarbamic acid
Predformulacné stúdiá potenciálneho lokálneho anestetika zo skupiny derivátov kyseliny fenylkarbámovej.