title: Erythroleukemia: a comparison between the previous FAB approach and the WHO classification.
abstract: Erythroleukemia is, within FAB classification, a proliferation of erythroblasts superior to 50% and of myeloblasts superior to 30%. The new WHO classification abolishes the frontier between RAEB-t with 20% and leukemia with 30% of blasts. AML6 variant is a new entity characterized by the proliferation of immature erythroblasts and the absence of non-erythroid blast cells. We analyzed 16 erythroleukemia, 5 RAEB-t and 2 AML6 variants to clarify their relationship. We suggest on survival, karyotype and cytologic characteristics that secondary erythroleukemia are the same entity as RAEB-t, confirming the WHO classification and that amongst de novo erythroleukemia, there is 'AML6 variant' with pure erythroid lineage proliferation.
authors.affiliation: Service d'hématologie, Hôpital Cochin, 27 rue du Faubourg St-Jacques, 75014 Paris, France. parksophie@yahoo.com
authors.forename: Sophie
authors.initials: S
authors.lastname: Park
authors.forename: Françoise
authors.initials: F
authors.lastname: Picard
authors.forename: Zahia
authors.initials: Z
authors.lastname: Azgui
authors.forename: Franck
authors.initials: F
authors.lastname: Viguie
authors.forename: Annabelle
authors.initials: A
authors.lastname: Merlat
authors.forename: Martine
authors.initials: M
authors.lastname: Guesnu
authors.forename: Véronique
authors.initials: V
authors.lastname: Leblond
authors.forename: François
authors.initials: F
authors.lastname: Dreyfus
mesh_terms: D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000145:classification* / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D014944:World Health Organization