Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma.
Increased expression of survivin has been shown to be a negative predictor of survival in patients with soft-tissue sarcoma. We investigated 89 adults with soft-tissue sarcomas to ascertain the relation between co-expression of survivin and human telomerase reverse transcriptase (TERT) transcripts and prognosis. We quantified mRNA expression of survivin and TERT transcripts. Cox's proportional-hazards regression model showed co-expression of both genes to be a significant negative prognostic factor for patients with stage I to stage IV tumours (p=0 small middle dot0004; relative risk 20 small middle dot1, 95% CI 3 small middle dot8-106 small middle dot4) and for those at stage II and III (p=0 small middle dot0002; 42 small middle dot1, 6 small middle dot0-294 small middle dot9) compared with low expression of both genes. Co-expression of survivin and TERT transcripts identifies patients at high risk of tumour-related death.
Würl
Peter
P
Kappler
Matthias
M
Meye
Axel
A
Bartel
Frank
F
Köhler
Thomas
T
Lautenschläger
Christine
C
Bache
Matthias
M
Schmidt
Hannelore
H
Taubert
Helge
H
D000328:Adult; D002868:Chromosomal Proteins, Non-Histone / Q000302:isolation & purification / Q000378:metabolism*; D004268:DNA-Binding Proteins; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008297:Male; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D011379:Prognosis; D016016:Proportional Hazards Models; D012509:Sarcoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D000077022:Survivin; D019098:Telomerase / Q000302:isolation & purification / Q000378:metabolism*; D013997:Time Factors
C107489:BIRC5 protein, human; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin; C509186:TERT protein, human; D019098:Telomerase