[Changes in secretion and composition of saliva with aging].
About 30% of the elderly suffer from oral dryness and related complaints. Therefore, it is often assumed that salivary secretion reduces with age. Nevertheless, salivary flow rate data in healthy elderly--that are persons without any medication and not suffering from any (treatment related) salivary gland disorder--revealed no significant age-related decrease other than a slight decrease of the secretion from the (sero)mucous glands under conditions of minimal or extended stimulation. No age-related changes were observed in the secretion of parotis saliva. In contrast, some age-related changes occur in the organic composition of saliva. The reported decrease in the concentrations of kallikrein, sIgA, low-molecular mucin and high-molecular mucin might be related to a somewhat decreased immunologic and non-immunologic defense of the oral cavity in the elderly.
Vissink
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Kliniek voor Mondziekten, Kaakchirurgie en Bijzondere Tandheelkunde, Academisch Ziekenhuis Groningen, postbus 30.001, 9700 RB Groningen.
Spijkervet
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FK
van Nieuw Amerongen
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D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology*; D064420:Drug-Related Side Effects and Adverse Reactions; D005850:Geriatric Dentistry; D006801:Humans; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism*; D012472:Salivation / Q000502:physiology; D012636:Secretory Rate / Q000502:physiology
Veranderingen in secretie en samenstelling van speeksel met het ouder worden.