title: [Celecoxib induced toxiderma with positive patch-test].
abstract: BACKGROUND
  Celecoxib (Celebrex(R)) is a new generation non-steroidal anti-inflammatory drug, recently introduced in France. We report a maculopapular rash due to this drug with positive patch-tests.
  
  
  METHODS
  A forty year-old man received with 3 tablets/day of celecoxib for intercostal pain. Nine days after initiation of treatment a maculopapular rash appeared. At the end of treatment, the eruption persisted for two days, then rapidly improved within one week. Six weeks later, patch-tests with celecoxib diluted at 20 p. 100 in petrolatum were positive at 48 hours.
  
  
  CONCLUSIONS
  Cutaneous reactions due to celecoxib are rare. In our case report, the delay, clinical aspect, improvement on withdrawal of treatment and positive patch test all emphasize the imputability of celecoxib. We wish to underline the possible cutaneous reactions with this new non-steroidal anti-inflammatory drug.
authors.affiliation: Service de Dermatologie, Centre Hospitalier Saint-Philibert, Université Catholique de Lille, 115, rue du Grand But, BP 249, 59462 Lille.
authors.forename: S
authors.initials: S
authors.lastname: Verbeiren
authors.forename: C
authors.initials: C
authors.lastname: Morant
authors.forename: H
authors.initials: H
authors.lastname: Charlanne
authors.forename: K
authors.initials: K
authors.lastname: Ajebbar
authors.forename: J
authors.initials: J
authors.lastname: Caron
authors.forename: P
authors.initials: P
authors.lastname: Modiano
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D000068579:Celecoxib; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D011720:Pyrazoles; D012882:Skin Tests; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*; D013607:Tablets; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013449:Sulfonamides; D013607:Tablets; D000068579:Celecoxib
vernacular_title: Toxidermie au célécoxib (Cerebrex(R)) avec test épicutané positif.