title: Tuberculosis in Spain: epidemiological pattern and clinical practice.
abstract: METHODS
  Thirteen Autonomous Regions in Spain.
  
  
  OBJECTIVE
  To study the incidence of all forms of tuberculosis (TB) and investigate clinical practice in TB.
  
  
  METHODS
  Cases of all forms of tuberculosis diagnosed in the study setting from May 1986 to April 1997 were identified though active search of different databases. Clinical and epidemiological information on cases was collected from clinical records or by interview with physicians.
  
  
  RESULTS
  The overall incidence of all forms of tuberculosis was 38.5/100,000 and the incidence of smear-positive disease was 13.83/100,000. Most cases (97.1%) were Spanish nationals, with rates higher in men than in women (52.7/100,000 vs. 24.87/100,000) and in groups aged 25-34 and 75 years and over (61.35/100,000 and 59.35/100,000, respectively). Disseminated forms were frequent (6.6%), and the most common risk factor was human immunodeficiency virus (HIV) infection (17.7% of cases). Hospitalisation was common (71.6%). Microbiological confirmation of diagnosis was sought for 87.7% of the cases (91.8% of pulmonary vs. 75.5% of extra-pulmonary cases), and 65.2% were culture-positive (73.8% of pulmonary vs. 39.7% of extra-pulmonary cases). HIV-infected patients were treated in almost equal proportions with three or four drugs (49.7% and 48.2%, respectively), while HIV-negative cases or those whose HIV status was unknown were usually treated with three drugs.
  
  
  CONCLUSIONS
  The epidemiological pattern of TB in Spain is different to other industrialised countries in the age distribution of cases and the proportions of foreigners and cases with HIV infection. Microbiological confirmation of diagnosis is more common in pulmonary than in extra-pulmonary disease, and treatment with four drugs more frequent in HIV-positive cases.
authors.affiliation: Unidad de Investigación en Tuberculosis, Instituto de Salud Carlos III, Madrid, Spain. mdiez@isciii.es
authors.forename: M
authors.initials: M
authors.lastname: Diez
authors.forename: C
authors.initials: C
authors.lastname: Huerta
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authors.lastname: Moreno
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authors.initials: T
authors.lastname: Caloto
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authors.lastname: Guerra
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authors.lastname: Pozo
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authors.lastname: Alcaide
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authors.lastname: Cardenal
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authors.lastname: Domínguez
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authors.lastname: Gayoso
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authors.lastname: Gutiérrez
authors.forename: M J
authors.initials: MJ
authors.lastname: López
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authors.lastname: Muñoz
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authors.lastname: Navarro
authors.forename: M
authors.initials: M
authors.lastname: Picó
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authors.initials: JR
authors.lastname: Quirós
authors.forename: F
authors.initials: F
authors.lastname: Robles
authors.forename: J M
authors.initials: JM
authors.lastname: Sánchez
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authors.initials: H
authors.lastname: Vanaclocha
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authors.lastname: Vega
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology; D013997:Time Factors; D014376:Tuberculosis / Q000453:epidemiology*