title: Bio-barcodes based on oligonucleotide-modified nanoparticles.
abstract: By utilizing oligonucleotide-modified Au nanoparticles encoded with sequences that act as biobarcodes, one can screen for multiple target polyvalent proteins simultaneously in one solution. This novel concept was demonstrated with two types of detection formats, a homogeneous assay and one based on oligonucleotide microarrays. With such an approach, one can prepare an extraordinarily large number of barcodes from synthetically accessible oligonucleotides (e.g., a 12-mer sequence offers 4(12) possible barcodes).
authors.affiliation: Northwestern University, Department of Chemistry and Institute for Nanotechnology, Evanston, Illinois 60208, USA.
authors.forename: Jwa-Min
authors.initials: JM
authors.lastname: Nam
authors.forename: So-Jung
authors.initials: SJ
authors.lastname: Park
authors.forename: Chad A
authors.initials: CA
authors.lastname: Mirkin
mesh_terms: D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry*; D007073:Immunoglobulin E / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D009841:Oligonucleotides / Q000737:chemistry*
chemical_list: D007074:Immunoglobulin G; D009841:Oligonucleotides; D007073:Immunoglobulin E; D004247:DNA