title: [Saponins and hemolytic activity. Saponins and glycosides from five species of Sapindaceae].
abstract: The haemolytic activity of saponins has been a known phenomenon for many years. In this work, structure-activity relationships were established from various triterpene saponins distinguishing hemolytic activity between mono- and bidesmosidic saponins. Saponins structure in Sapindaceae serve as a chimiotaxonomic criteria for dividing the species into two sub-families. In order to verify this criteria, five species were studied: Smelophyllum capense and Dimocarpus fumatus from the sub-family Sapindoideae, Filicium decipiens, Hippobromus pauciflorus, and Harpullia cupanioides from the sub-family Dodonaeoideae. Structure of eleven new saponins were elucidated from four species by the study of homo- and heteronuclear advanced NMR experiments and MS. Other metabolites were also isolated from Dimocarpus fumatus, including isoprenypchromenes and three new glycosides of long chain fatty alcohols.
authors.affiliation: L'Université de Reims Champagne-Ardenne no 208, 1997 Laboratoire de Pharmacognosie, UMR 6013 au CNRS, Faculté de Pharmacie, 51, rue Cognacq-Jay F51100 Reims.
authors.forename: L
authors.initials: L
authors.lastname: Voutquenne
mesh_terms: D002240:Carbohydrate Sequence; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D029631:Sapindaceae / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D013045:Species Specificity
chemical_list: D006027:Glycosides; D012503:Saponins
vernacular_title: Saponines et activités hémolytiques. Saponines et glycosides de cinq espèces de Sapindaceae.