title: [Papilloedema and POEMS syndrome].
abstract: POEMS syndrome stands for the first letter of the words: polyneuropathy (P), organomegaly (O), endocrinopathy (E), monoclonal component (M), changes of the tegument (S-skin). In 33-84% of the cases, chronic bilateral papilloedema is associated with the syndrome. The disease is a multisystem disorder, a plasma cell dyscrasia being present, often associated with Castleman disease. Inflammatory cytokines, endothelial vascular growth factor and human herpes virus-8 are thought to play an important role in pathogenesis. This summary is about a 16 year old female patient, where the diagnosis of POEMS syndrome was elaborated based on the systematization of the clinical symptomatology, developed over a long period of time. Based on the latest data from literature, peculiarities of diagnosis, pathogenesis and therapy of the disease are being discussed.
authors.affiliation: Clinica de Oftalmologie, Timişoara.
authors.forename: G H
authors.initials: GH
authors.lastname: Munteanu
authors.forename: M
authors.initials: M
authors.lastname: Munteanu
authors.forename: M
authors.initials: M
authors.lastname: Budău
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016878:POEMS Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D010211:Papilledema / Q000209:etiology*; D011379:Prognosis; D012307:Risk Factors
vernacular_title: Edem papilar şi sindrom POEMS.