title: Licamichauxiioic-A and -B acids--two ent-kaurene diterpenoids from Licania michauxii.
abstract: Bioassay-guided fractionation allowed the isolation of two new cytotoxic ent-kaurene diterpenoids, licamichauxiioic-A and -B acids (1 and 2) from the root extract of Licania michauxii Prance (Chrysobalanaceae). They were characterized as ent-15-oxo-9(11),16-kauradien-19-oic acid (1) and ent-15-oxo-13(14),16-kauradien-19-oic acid (2) by various spectroscopic methods, in particular, 1D and 2D NMR spectra, and chemical evidence.
authors.affiliation: Walker Cancer Research Institute, Inc, Tallahassee, Florida 32308-3729, USA. swapan97@aol.com
authors.forename: Swapan K
authors.initials: SK
authors.lastname: Chaudhuri
authors.forename: Ramesh Babu
authors.initials: RB
authors.lastname: Badisa
authors.forename: Elsa
authors.initials: E
authors.lastname: Pilarinou
authors.forename: Evan H
authors.initials: EH
authors.lastname: Walker
mesh_terms: D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D005431:Florida; D013058:Mass Spectrometry; D008745:Methylation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes; C456093:licamichauxiioic-A acid; C456092:licamichauxiioic-B acid