title: The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats.
abstract: Congenic BioBreeding (BB) rats, homozygous for the autosomal lymphopenia (Lyp) gene (Lyp/Lyp), heterozygous (Lyp/+), or wild-type (+/+), were immunized with the T cell-dependent bacteriophage PhiX174 to determine effects of Lyp on primary and secondary antibody responses. The primary PhiX174 antibody response did not differ between the three different genotypes. In contrast, the secondary immune response, expressed as the peak neutralizing titer, was markedly reduced in Lyp/Lyp (9.9+/-3.2; mean value+/-S.E.M. for seven rats) compared to both Lyp/+ (51+/-12; n=13; P=0.006) and +/+ (100+/-20; n=7; P=0.004) BB rats. We suggest that the secondary antibody response to the T cell-dependent neoantigen PhiX174 is linked in a recessive manner to genetic factor(s) in the Lyp gene region.
authors.affiliation: Robert H. Williams Laboratory, Department of Medicine, University of Washington, Seattle, WA 98125, USA.
authors.forename: Leila
authors.initials: L
authors.lastname: Clark
authors.forename: Carla
authors.initials: C
authors.lastname: Greenbaum
authors.forename: Jianjie
authors.initials: J
authors.lastname: Jiang
authors.forename: Ake
authors.initials: A
authors.lastname: Lernmark
authors.forename: Hans
authors.initials: H
authors.lastname: Ochs
mesh_terms: D000818:Animals; D020296:Animals, Congenic; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D010584:Bacteriophage phi X 174 / Q000276:immunology*; D004195:Disease Models, Animal; D008231:Lymphopenia / Q000097:blood / Q000276:immunology*; D051381:Rats
chemical_list: D000914:Antibodies, Viral