title: [Traumatic head injury in children: physiopathology and clinical management].
abstract: Traumatic brain injury (TBI) constitutes a major health and economic problem for developed countries, being one of the main causes of mortality and morbidity in children. In a busy traumatology center, a child will be admitted daily in the emergency department with head trauma injury. The anaesthesiologist must have a complete understanding of the pathophysiology and develop a practical knowledge of initial management of such patients. Traumatic brain injury may have intracranial and systemic effects that combine to give global cerebral ischaemia. Injury to the nervous system, irrespective of the primary injury, initiates a multitude of inflammatory cascades resulting in secondary brain injury. The consequence of these secondary brain injuries is most often as important, if not, more important than the primary injury. This period of brain inflammation can last up to three weeks and renders the brain more susceptible to the effects of systemic insults such as hypotension, hypoxia and or pyrexia. It has been shown in post-mortem examination of patients dying from severe traumatic brain injury that more than 91% had evidence of secondary ischaemic damage. These secondary injuries may be responsible for the clinical presentation of the "child who talk and die". The concept of "cerebral protection" has been extended to encompass the active treatment of secondary injury and the prevention of cerebral ischaemia. Initial care focuses on achieving oxygenation, airway control and treatment of arterial hypotension.
authors.affiliation: Divisions of Neurosurgical Anaesthesia and Cardiovascular Anaesthesia Research, Department of Anaesthesia, Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8. bruno@anaes.sickkids.on.ca
authors.forename: B
authors.initials: B
authors.lastname: Bissonnette
authors.forename: M
authors.initials: M
authors.lastname: Vinchon
mesh_terms: D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D002560:Cerebrovascular Circulation / Q000502:physiology; D002648:Child; D006259:Craniocerebral Trauma / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D009416:Nerve Regeneration
vernacular_title: Les différentes lésions cérébrales traumatiques du nourrisson et du petit enfant: mécanismes et clinique.