title: Otosclerosis: a genetically heterogeneous disease involving at least three different genes.
abstract: Otosclerosis is caused by abnormal bone homeostasis of the otic capsule, resulting in hearing impairment in 0.3%-0.4% of the white population. The etiology of the disease remains unclear and environmental as well as genetic factors have been implicated. We localized the first autosomal-dominant locus to chromosome 15 in 1998 (OTSC1) in an Indian family and, recently, we reported the localization of a second gene for otosclerosis to a 16 cM interval on chromosome 7q (OTSC2). In this study, we recruited and analyzed nine additional families (seven Belgian and two Dutch families with 53 affected and 20 unaffected subjects) to investigate the importance of these loci in autosomal-dominant otosclerosis. We completed linkage analysis with three microsatellite markers of chromosome 15 (D15S652, D15S1004, D15S657) and five microsatellite markers of chromosome 7 (D7S495, D7S2560, D7S684, D7S2513, D7S2426). In two families, results compatible with linkage to OTSC2 were found, but in the seven remaining families OTSC1 and OTSC2 were excluded. Heterogeneity testing provided significant evidence for genetic heterogeneity, with an estimated 25% of families linked to OTSC2. These results indicate that, besides OTSC1 and OTSC2, there must be at least one additional otosclerosis locus.
authors.affiliation: Department of Medical Genetics, University of Antwerp (UIA), Antwerp, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Van Den Bogaert
authors.forename: P J
authors.initials: PJ
authors.lastname: Govaerts
authors.forename: E M R
authors.initials: EM
authors.lastname: De Leenheer
authors.forename: I
authors.initials: I
authors.lastname: Schatteman
authors.forename: M
authors.initials: M
authors.lastname: Verstreken
authors.forename: W
authors.initials: W
authors.lastname: Chen
authors.forename: F
authors.initials: F
authors.lastname: Declau
authors.forename: C W R J
authors.initials: CW
authors.lastname: Cremers
authors.forename: P H
authors.initials: PH
authors.lastname: Van De Heyning
authors.forename: F E
authors.initials: FE
authors.lastname: Offeciers
authors.forename: T
authors.initials: T
authors.lastname: Somers
authors.forename: R J H
authors.initials: RJ
authors.lastname: Smith
authors.forename: G
authors.initials: G
authors.lastname: Van Camp
mesh_terms: D002884:Chromosomes, Human, Pair 15; D002897:Chromosomes, Human, Pair 7; D005192:Family Health; D005260:Female; D005799:Genes, Dominant; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D010040:Otosclerosis / Q000235:genetics*; D010375:Pedigree