[Rapidly evolving diabetic mononeuritis multiplex. Favorable outcome after immunosuppressive treatment].
A 61 year-old man with type 2 diabetes mellitus presented with an extremely rapid and aggressive mononeuritis multiplex. Four months after onset, he had severe postural hypotension and at least 6 cranial nerves and 4 somatic nerves were involved. Extensive work-up failed to discover any etiology for the neuropathy apart from diabetes. Treatment with corticosteroids, i.v. immunoglobulins and cyclosporin was followed by progressive but sustained improvement. This case and few other published ones suggest that some particularly aggressive forms of diabetic neuropathy have an immune mechanism and may be treated favorably with immunosuppressor drugs.
Awada
A
A
Service de Neurologie, King Fahd National Guard Hospital, POB 22490, Riyadh 11426, Arabie Saoudite. awadaadnan@yahoo.com
Dehoux
E
E
al Jumah
M
M
al Ayafi
H
H
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D003389:Cranial Nerve Diseases / Q000188:drug therapy / Q000209:etiology; D016572:Cyclosporine / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000188:drug therapy / Q000209:etiology*; D004359:Drug Therapy, Combination; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020422:Mononeuropathies / Q000188:drug therapy / Q000209:etiology*; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D016572:Cyclosporine
Multinévrite diabétique d'évolution rapide. Amélioration par traitement immunosuppresseur.