title: Mbx, a novel mouse homeobox gene.
abstract: The homeobox gene Mbxis thought to play important roles in the development of eyes and tectum in zebrafish. We isolated mouse Mbx cDNA and analyzed its expression pattern during early mouse embryogenesis. Expression is predominantly restricted to the midbrain region at E9.5. At subsequent stages of development, Mbx transcripts were also found in the forebrain in addition to midbrain. Thus, the Mbx gene provides a useful molecular marker for early mouse midbrain development and may play a critical role in brain development.
authors.affiliation: Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Atsuo
authors.initials: A
authors.lastname: Kawahara
authors.forename: Andreas
authors.initials: A
authors.lastname: Teufel
authors.forename: Mahua
authors.initials: M
authors.lastname: Mukhopadhyay
authors.forename: Yangu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Igor B
authors.initials: IB
authors.lastname: Dawid
authors.forename: Heiner
authors.initials: H
authors.lastname: Westphal
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000196:embryology; D005314:Embryonic and Fetal Development / Q000235:genetics; D005801:Genes, Homeobox; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D012261:Ribonucleoproteins / Q000235:genetics*; D015027:Zebrafish
chemical_list: D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D012261:Ribonucleoproteins; C408084:hnRNPA3 protein, rat