title: Magnetocardiographic and magnetic resonance imaging for noninvasive localization of ventricular arrhythmia origin in a model of nonischemic cardiomyopathy.
abstract: Ventricular arrhythmia may in myocardial failure arise as a consequence of remodeling related to hypertrophy and dilatation. In surgically repaired tetralogy of Fallot (TOF), which carries a substantial risk for ventricular arrhythmias and sudden death, the situation is even more complex and several potential arrhythmia mechanisms exist. The authors wanted to test a completely noninvasive localization technique, magnetocardiography (MCG) and magnetic resonance imaging (MRI), to define the origin of ventricular ectopic beats (VEBs) in this model of nonischemic cardiomyopathy. The study included 84 patients with surgically repaired TOF, all 11 subjects with VEBs Lown grade > or = 2 on a 24-hour Holter were included. From 37-channel MCG registrations, the underlying current dipole was computed for the VEBs, and for anatomic correlation MRIs were produced. Eight patients had VEBs of altogether 11 morphologies during the MCG recording. The RVOT was the origin of 6 VEBs, while 4 originated from the RV free wall, and 1 VEB could not be localized. Applying this completely noninvasive technique, it was possible to define different origins of RV ectopies in a complex heart model. Thus, VEBs originated from the RVOT, suggesting a relation to surgical scars and from the nonoperated parts of the RV, supporting that ventricular remodeling might be of equal importance for arrhythmogenesis in this model of cardiomyopathy. This technique can assist in answering the important question of whether there is any difference in prognostic information depending on the origin and related mechanism of VEBs in this and other high risk conditions.
authors.affiliation: Department of Cardiology, Karolinska Institutet at Karolinska Hospital, Stockholm, Sweden. par-lennart.agren@ltdalarna.se
authors.forename: Pär Lennart
authors.initials: PL
authors.lastname: Agren
authors.forename: Håkan
authors.initials: H
authors.lastname: Göranson
authors.forename: Hans
authors.initials: H
authors.lastname: Jonsson
authors.forename: Lennart
authors.initials: L
authors.lastname: Bergfeldt
mesh_terms: D000328:Adult; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D013771:Tetralogy of Fallot / Q000150:complications* / Q000601:surgery; D018879:Ventricular Premature Complexes / Q000175:diagnosis* / Q000209:etiology