Functional integration of adult-born neurons.
Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be resolved. Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.
Carlén
Marie
M
Department of Cell and Molecular Biology, Medical Nobel Institute, Stockholm, Sweden.
Cassidy
Robert M
RM
Brismar
Hjalmar
H
Smith
Gregory A
GA
Enquist
Lynn W
LW
Frisén
Jonas
J
D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation; D002772:Cholera Toxin / Q000378:metabolism; D018891:Dentate Gyrus / Q000166:cytology; D011558:Herpesvirus 1, Suid / Q000502:physiology; D006624:Hippocampus / Q000166:cytology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000502:physiology* / Q000821:virology; D009830:Olfactory Bulb / Q000166:cytology* / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology* / Q000821:virology; D013569:Synapses / Q000378:metabolism / Q000821:virology
D015415:Biomarkers; D016760:Proto-Oncogene Proteins c-fos; D002772:Cholera Toxin