title: Inhibition of proliferation of human lymphoma cells U937 by a 50 Hz electromagnetic field.
abstract: Weak pulsating electromagnetically induced fields (PEMF) by Helmholtz coils changes cell metabolism, if cells are treated with a certain range of frequency and amplitude. The influence on proliferation of human histiocytic lymphoma cells U937 has been studied applying a sinusoidal 50 Hz field with amplitudes of the flux density B = 0.3 to 4.7 mT for 4 days. No difference between experiment and control was found in the region 0.3 and 2 mT. However, stronger fields (> or =2.5 mT) inhibit cell division. Fields > or =3.5 mT treatment kill > or =80% of the cell number at the beginning (1.5 x 10(5)/ml). This effect may be an electromagnetocally induced cell death as the first step for a non-invasive application on cell proliferation process.
authors.affiliation: Laboratory Cell Culture, Institute of Virology, Friedrich-Schiller-University Jena, Germany. i6glbr@rz.uni-jena.de
authors.forename: B
authors.initials: B
authors.lastname: Glück
authors.forename: V
authors.initials: V
authors.lastname: Güntzschel
authors.forename: H
authors.initials: H
authors.lastname: Berg
mesh_terms: D017209:Apoptosis; D002455:Cell Division; D004574:Electromagnetic Fields; D006801:Humans; D013997:Time Factors; D020298:U937 Cells