[Pathogenetic role of prostanoids in disorders of sodium reabsorption during development of acute renal insufficiency].
The experiments were carried out on 36 male rats with an acute renal insufficiency--sublimate-induced nephropathy. An increased amount of both tromboxan A2, and prostaglandine F2a has been shown to play a pathogenic role in the disorders of the main energy-dependent process in kidney--reabsorbtion of sodium ions. The negative correlative relation between the concentration of sodium ions in plasma and an increased amount of prostaglandine E2 in a kidney papilla can be explained by the hyperfunction of the interstitial cells of a kidney papilla and with a natriuretic effect of prostaglandine E2 at the level of collective tubules.
Pishak
V P
VP
Bukovinian State Medical Academy, Ministry of Public Health of the Ukraine, Chernivtsy.
Rohovyĭ
Iu Ie
IuIe
Filipova
L O
LO
Stepanova
Ie S
IeS
D000042:Absorption; D058186:Acute Kidney Injury / Q000503:physiopathology*; D000818:Animals; D015237:Dinoprost / Q000502:physiology; D015232:Dinoprostone / Q000502:physiology; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology; D007679:Kidney Medulla / Q000378:metabolism; D007685:Kidney Tubules, Collecting / Q000378:metabolism; D008297:Male; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D013928:Thromboxane A2 / Q000502:physiology
D011453:Prostaglandins; D013928:Thromboxane A2; D012964:Sodium; D015237:Dinoprost; D015232:Dinoprostone
Patohenetychne znachennia prostanoïdiv u porushenni reabsorbtsiï ioniv natriiu za umov rozvytku hostroï nyrkovoï nedostatnosti.