Increased endometrial thickness on the day of human chorionic gonadotropin injection does not adversely affect pregnancy or implantation rates following in vitro fertilization-embryo transfer.
OBJECTIVE
To investigate the controversy whether an increased endometrial thickness has an effect on pregnancy, implantation, or abortion rates in in vitro fertilization-embryo transfer (IVF-ET) cycles.


METHODS
Retrospective analysis.


METHODS
A university-based IVF center.


METHODS
Five hundred seventy women under the age of 40.


METHODS
Measurements of endometrial thickness on day of human chorionic gonadotropin (hCG) administration. Cycles were compared by endometrial thickness of </=14 mm in 510 women to a thickness of >14 mm in 60 women.


METHODS
Implantation, pregnancy, and abortion rates.


RESULTS
Implantation, pregnancy, and abortion rates were similar in each group. In cycles where the endometrial thickness was </=14 mm, the rates were 20.9%, 43.1%, and 11.8% compared with 25.5%, 48.3%, and 13.8% in cycles >14 mm.


CONCLUSIONS
No adverse effects of a thickened endometrium were demonstrated on implantation, pregnancy, or abortion rates in the first IVF-ET cycle. These findings fail to corroborate with those of Weissman et al. and support those of Yakin et al.
Dietterich
Carole
C
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Camden, New Jersey, USA.
Check
Jerome H
JH
Choe
Jung K
JK
Nazari
Ahmad
A
Lurie
Deborah
D
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D012189:Retrospective Studies; D016896:Treatment Outcome; D014463:Ultrasonography
D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone