Suppression of cortical myoclonus by levetiracetam.
A 16-year-old boy suffered severely disabling posthypoxic myoclonus. Neurophysiological investigation showed cortical but not reticular reflex myoclonus. Add-on therapy with levetiracetam significantly improved the patient's clinical condition, suppressed cortical myoclonus-associated spikes, and enabled further neurorehabilitation.
Schauer
Robert
R
Department of Neurology, Hospital Hochzirl, Zirl, Austria.
Singer
Markus
M
Saltuari
Leopold
L
Kofler
Markus
M
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000293:injuries; D004292:Dominance, Cerebral / Q000502:physiology; D004359:Drug Therapy, Combination; D004834:Epilepsy, Post-Traumatic / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000175:diagnosis / Q000188:drug therapy*; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam