Secondary metabolites from Centaurea deusta with antimicrobial activity.
The aerial parts of Centaurea deusta Ten. afforded in addition to several known compounds, mainly sesquiterpene lactones, one new eudesmanolide and one new elemane derivative. Structures of the new compounds were elucidated by spectroscopic methods. The in vitro antifungal and antibacterial activities of the isolated compounds was tested, using the microdilution method. All compounds tested showed high antifungal activity.
Karioti
Anastasia
A
Department of Pharmacognosy, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, Greece.
Skaltsa
Helen
H
Lazari
Diamanto
D
Sokovic
Marina
M
Garcia
Begoña
B
Harvala
Catherine
C
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D019659:Asteraceae / Q000378:metabolism*; D007783:Lactones / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D010407:Penicillium / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D007783:Lactones; D012717:Sesquiterpenes