title: Rhinocerebral mucormycosis in the era of lipid-based amphotericin B: case report and literature review.
abstract: Rhinocerebral mucormycosis (RCM) is an invasive fungal infection that necessitates, in most cases, aggressive surgical debridement and high cumulative, often nephrotoxic doses of amphotericin B. A 50-year-old woman with RCM was treated successfully with amphotericin B lipid complex as primary therapy. The patient previously had displayed progressive intracranial involvement and rising serum creatinine levels while receiving the conventional (nonlipid) form of amphotericin B. A literature review identified only a few cases where systemic antifungal therapy was administered, with minimal or no surgery. Our case further supports that amphotericin B lipid complex can be used as primary therapy in selected patients with RCM, without the need for surgical exenteration.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.
authors.forename: Kristin E
authors.initials: KE
authors.lastname: Mondy
authors.forename: Bruce
authors.initials: B
authors.lastname: Haughey
authors.forename: Philip L
authors.initials: PL
authors.lastname: Custer
authors.forename: Franz J
authors.initials: FJ
authors.lastname: Wippold
authors.forename: David J
authors.initials: DJ
authors.lastname: Ritchie
authors.forename: Linda M
authors.initials: LM
authors.lastname: Mundy
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008055:Lipids / Q000627:therapeutic use*; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D012852:Sinusitis / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000935:Antifungal Agents; D008055:Lipids; D000666:Amphotericin B