The lutropin/choriogonadotropin receptor, a 2002 perspective.
Reproduction cannot take place without the proper functioning of the lutropin/choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does not occur in females and Leydig cells do not develop normally in the male. Also, because the LHR is essential for sustaining the elevated levels of progesterone needed to maintain pregnancy during the first trimester, disruptions in the functions of the LHR during pregnancy have catastrophic consequences. As such, a full understanding of the biology of the LHR is essential to the survival of our species. In this review we summarize our current knowledge of the structure, functions, and regulation of this important receptor.
Ascoli
Mario
M
Department of Pharmacology, The University of Iowa, Iowa City, 52242-1109, USA. marioascoli@uiowa.edu
Fanelli
Francesca
F
Segaloff
Deborah L
DL
D000595:Amino Acid Sequence / Q000235:genetics; D000818:Animals; D006063:Chorionic Gonadotropin / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D011247:Pregnancy; D012333:RNA, Messenger / Q000378:metabolism; D011974:Receptors, LH / Q000235:genetics / Q000502:physiology*; D012098:Reproduction / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013329:Structure-Activity Relationship
D006063:Chorionic Gonadotropin; D012333:RNA, Messenger; D011974:Receptors, LH; D007986:Luteinizing Hormone