title: The effects of intravenous almitrine on oxygenation and hemodynamics during one-lung ventilation.
abstract: One-lung ventilation (OLV) induces an increase in pulmonary shunt sometimes associated with a decrease in PaO2 despite ventilation with 100% oxygen. PaO2 improvement has been reported in one-lung ventilated animals receiving IV almitrine, a pulmonary vasoconstrictor. We evaluated the ability of almitrine to prevent a decrease in PaO2 during OLV. Patients without pulmonary hypertension undergoing OLV for lung surgery were randomly assigned to receive either placebo (Group P, n = 8) or almitrine infusion at a rate of 8 microg x kg(-1) x min(-1) (Group A, n = 8) from the start of OLV. Gasometric and hemodynamic values were recorded with the patient in the lateral decubitus position during two-lung ventilation and at 10-min intervals during OLV over a 30-min period (OLV-10, OLV-20, OLV-30). Compared with the values found during two-lung ventilation (434 +/- 22 mm Hg in Group P and 426 +/- 23 mm Hg in Group A), PaO2 decreased at OLV-10 (305 +/- 46 mm Hg), OLV-20 (203 +/- 20 mm Hg), and OLV-30 (178 +/- 18 mm Hg) in Group P (P < 0.05) and at OLV-20 (354 +/- 25 mm Hg) and OLV-30 (325 +/- 17 mm Hg) in Group A (P < 0.05). PaO2 values differed between the groups at OLV-20 and OLV-30 (P < 0.05). Pulmonary artery pressure and cardiac output did not change. In conclusion, 8 microg x kg(-1) x min(-1) IV almitrine prevents and limits the OLV-induced decrease in PaO2 without causing any hemodynamic modification.
  
  
  CONCLUSIONS
  Eight microg x kg(-1) x min(-1) IV almitrine limits one-lung ventilation-induced decrease in PaO2 without causing any hemodynamic modification in patients without pulmonary hypertension.
authors.affiliation: Department of Anesthesiology, Hôpital Foch, Suresnes, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Moutafis
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dalibon
authors.forename: Ngai
authors.initials: N
authors.lastname: Liu
authors.forename: Guy
authors.initials: G
authors.lastname: Kuhlman
authors.forename: Marc
authors.initials: M
authors.lastname: Fischler
mesh_terms: D015765:Almitrine / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D011013:Pneumonectomy; D011446:Prospective Studies; D011652:Pulmonary Circulation / Q000187:drug effects; D012121:Respiration, Artificial / Q000379:methods; D019141:Respiratory System Agents / Q000008:administration & dosage*
chemical_list: D019141:Respiratory System Agents; D002245:Carbon Dioxide; D015765:Almitrine; D010100:Oxygen