title: [Analyses of genetic model of psoriasis vulgaris].
abstract: OBJECTIVE
  To explore the possible genetic model of psoriasis vulgaris.
  
  
  METHODS
  The complex segregation analysis and heritability calculation were performed with the aid of Penrose method, Falconer regression method and SAGE-REGTL program.
  
  
  RESULTS
  It was found that in 1043 patients with psoriasis vulgaris, 305 patients (29.24%) have the family history of psoriasis, and 738 patients have not the family history. A ratio of s/q approached 1/(square root of q) with Penrose method, and the heritability values of psoriasis in the first-degree and second-degree relatives were 67.04%, 46.6% respectively. By complex segregation analysis, Mendelian, non-major-gene model and environment model were rejected for psoriasis.
  
  
  CONCLUSIONS
  The results suggest that psoriasis follows a pattern of polygenetic or multifactorial inheritance rather than single-gene inheritance.
authors.affiliation: Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, Anhui, 230022 P. R. China. ayzxj@mail.hf.ah.cn
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wang
authors.forename: Shanyu
authors.initials: S
authors.lastname: Chen
authors.forename: Fuxi
authors.initials: F
authors.lastname: Wang
authors.forename: Taofeng
authors.initials: T
authors.lastname: Liu
authors.forename: Zaixing
authors.initials: Z
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D011565:Psoriasis / Q000235:genetics*