Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice.
The anti-inflammatory effect of three flavonoids from the root of Scutellaria baicalensis (baicalein, baicalin and wogonin) was evaluated in a murine model of acute experimental colitis induced by dextran sulfate sodium (DSS). Baicalein, but not baicalin or wogonin, given orally at 20 mg/kg for ten days, ameliorates all the considered inflammatory symptoms of the induced colitis, such as body weight loss, blood haemoglobin content, rectal bleeding and other histological and biochemical parameters. The effect of baicalein was similar to that of sulfasalazine, the reference drug given at 50 mg/kg.
Hong
Tie
T
Jin
Guang-Bi
GB
Cho
Shigefumi
S
Cyong
Jong-Chol
JC
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy*; D016264:Dextran Sulfate / Q000494:pharmacology*; D005260:Female; D044950:Flavanones; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D019686:Lamiaceae; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D012460:Sulfasalazine / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D044950:Flavanones; D005419:Flavonoids; D010936:Plant Extracts; C038044:baicalin; D012460:Sulfasalazine; C006680:baicalein; D016264:Dextran Sulfate; C085514:wogonin