L-carnitine in experimental retinal ischemia-reperfusion injury.
The effect of L-carnitine on retinal ischemia-reperfusion injury was evaluated in guinea pigs. 90 min of pressure-induced retinal ischemia followed by 24 h of reperfusion was established in both eyes of 2 groups of animals receiving either L-carnitine (100 mg/kg repeated in 5 doses) or saline intraperitoneally. After enucleation of all the eyes, including those of a control group, malonyldialdehyde (MDA) levels and the thickness of the retinal tissue were measured in 3 groups. The mean MDA value and the tissue thickness of the L-carnitine-treated group were statistically insignificant versus the control group (p > 0.05 and p > 0.05, respectively). However, these values were significantly different in the group receiving saline versus the control group and that receiving L-carnitine (p < 0.001, p < 0.001 and p < 0.001, p < 0.001 respectively). L-Carnitine might be an alternative drug for ischemia-reperfusion injury of the retina.
Alagoz
Gursoy
G
Department of Ophthalmology, Firat University School of Medicine, Elazig, Turkey.
Celiker
Ulka
U
Ilhan
Nevin
N
Yekeler
Hayrettin
H
Demir
Tamer
T
Celiker
Huseyin
H
D000818:Animals; D002331:Carnitine / Q000627:therapeutic use*; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D012160:Retina / Q000187:drug effects* / Q000378:metabolism; D012164:Retinal Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
D008315:Malondialdehyde; D002331:Carnitine