title: Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling.
abstract: The paradigm that emerged from studies during the past decade established a central role for Jak-Stat (signal transducer and activator of transcription) signaling pathways in promoting the diverse cellular responses induced by interferon gamma (IFN-gamma). However, recent studies have shown that the IFN-gamma receptor activates additional signaling pathways and can regulate gene expression by Stat1-independent pathways. The diversity of gene-expression patterns mediated by Stat1-dependent and -independent mechanisms and the balance between these two pathways play an important role in the biological response to IFN-gamma.
authors.affiliation: Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA. starkg@ccf.org
authors.forename: Chilakamarti V
authors.initials: CV
authors.lastname: Ramana
authors.forename: M Pilar
authors.initials: MP
authors.lastname: Gil
authors.forename: Robert D
authors.initials: RD
authors.lastname: Schreiber
authors.forename: George R
authors.initials: GR
authors.lastname: Stark
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000276:immunology*; D005347:Fibroblasts; D005786:Gene Expression Regulation; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D020411:Oligonucleotide Array Sequence Analysis; D050794:STAT1 Transcription Factor; D015398:Signal Transduction / Q000276:immunology*; D015534:Trans-Activators / Q000276:immunology*
chemical_list: D004268:DNA-Binding Proteins; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D015534:Trans-Activators; D007371:Interferon-gamma