title: Differential expression of Otx2, Gbx2, Pax2, and Fgf8 in the developing vestibular and auditory sensory organs.
abstract: The vertebrate inner ear is a complex organ with vestibular and auditory sensory functions, which derives from a single ectoderm structure, the otic placode. The development and regional patterning of the otic primordium is determined by the restricted expression of several genes. Here, we show the expression pattern of three transcription factors (Otx2, Gbx2, Pax2) and of a member of the fibroblast growth factor family (Fgf8) in the developing chick inner ear, and we correlate these patterns with the developing sensory and nonsensory elements.
authors.affiliation: Departamento de Biología Celular, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
authors.forename: Hortensia
authors.initials: H
authors.lastname: Sánchez-Calderón
authors.forename: Gervasio
authors.initials: G
authors.lastname: Martín-Partido
authors.forename: Matías
authors.initials: M
authors.lastname: Hidalgo-Sánchez
mesh_terms: D000818:Animals; D001306:Auditory Pathways / Q000196:embryology*; D002642:Chick Embryo / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism*; D007758:Ear, Inner / Q000196:embryology* / Q000294:innervation*; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D017950:Ganglia, Sensory / Q000196:embryology; D018398:Homeodomain Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051857:Otx Transcription Factors; D051762:PAX2 Transcription Factor; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D051857:Otx Transcription Factors; D051762:PAX2 Transcription Factor; D015534:Trans-Activators; D014157:Transcription Factors; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors