[Colonic malacoplakia and ulcerative colitis: report of a case].
Malacoplakia is a form of chronic granulomatous inflammatory reaction that rarely affects the digestive tract and has exceptionally been reported in association with ulcerative colitis. We report a new case in a 58-year-old woman suffering from ulcerative colitis. As colitis worsened, the patient received systemic steroid therapy but symptoms did not improve. As colonic perforation was suspected, a sub-total colectomy was performed. Histopathological study revealed a diffuse infiltration of the colonic mucosa by sheets of large macrophages with eosinophilic granular cytoplasm and characteristic cytoplasmic inclusions (Michaelis-Gutmann bodies) together with active and chronic lesions of ulcerative colitis. Malacoplakia gradually disappeared under antibiotics and did not recur whereas ulcerative colitis remained active. In our case, as in three similar published cases associated with ulcerative colitis or Crohn's disease, malacoplakia was probably triggered by steroid therapy and was not clinically suspected. This particular and potentially severe inflammation must be recognized and treated in order to prevent worsening of the associated bowel disease.
Guinaudeau
Emmanuelle
E
Laboratoire d'Anatomie Pathologique, Centre Hospitalier Universitaire d'Angers, France.
Person
Bruno
B
Valo
Isabelle
I
Tuech
Jean-Jacques
JJ
Rousselet
Marie-Christine
MC
D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008287:Malacoplakia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008875:Middle Aged
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents
Association d'une malacoplakie colique et d'une rectocolite hémorragique: à propos d'un cas.