CPPD crystal-induced suppression of neutrophil apoptosis is regulated by the ERK1/2 and PI3-kinase/Akt pathways.
Tudan
C
C
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada. tudanc@shaw.ca
Jackson
J K
JK
Burt
H M
HM
D017209:Apoptosis / Q000187:drug effects*; D002131:Calcium Pyrophosphate / Q000494:pharmacology*; D003460:Crystallization; D053938:DNA Fragmentation; D006801:Humans; D007249:Inflammation / Q000209:etiology; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009504:Neutrophils / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D002131:Calcium Pyrophosphate; D019950:Mitogen-Activated Protein Kinase 1; D020928:Mitogen-Activated Protein Kinases; D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D051057:Proto-Oncogene Proteins c-akt; D014409:Tumor Necrosis Factor-alpha; C494918:AKT1 protein, human