title: Hypopituitarism, deficiency of factors V and VIII and von Willebrand factor: an uncommon association.
abstract: A 9 year-old boy with hypopituitarism and blood coagulation abnormalities is presented and discussed. The association between acquired von Willebrand disease and hypothyroidism has been reported but the combination of hypopituitarism and coagulopathy is unusual. Combined multiple clotting deficiencies are rare and, when present, factors V and VIII is the commonest association. Although it is known that hypothyroid patients may have a decrease in von Willebrand's factor (vWf) and factor VIII, there are no reports of hypopituitarism associated with combined deficiency of factors V, VIII, and vWf.
authors.affiliation: Pediatric Endocrinology Unit, Instituto da Criança Hospital das Clinicas, São Paulo University School of Medicine, Fundação Pró-Sangue Hemocentro de São Paulo, Brazil.
authors.forename: Nuvarte
authors.initials: N
authors.lastname: Setian
authors.forename: Caroline M
authors.initials: CM
authors.lastname: Tanaka
authors.forename: Durval
authors.initials: D
authors.lastname: Damiani
authors.forename: Vaê
authors.initials: V
authors.lastname: Dichtchekenian
authors.forename: Jorge D A
authors.initials: JD
authors.lastname: Carneiro
authors.forename: Elbio A
authors.initials: EA
authors.lastname: D'Amico
mesh_terms: D001778:Blood Coagulation Disorders / Q000097:blood / Q000150:complications; D002648:Child; D005166:Factor V Deficiency / Q000150:complications*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D007018:Hypopituitarism / Q000097:blood / Q000150:complications* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010902:Pituitary Gland / Q000473:pathology; D014842:von Willebrand Diseases / Q000097:blood / Q000150:complications* / Q000473:pathology