The molecular basis of Streptococcus equi infection and disease.
Streptococcus equi is the aetiological agent of strangles, one of the most prevalent diseases of the horse. The animal suffering and economic burden associated with this disease necessitate effective treatment. Current antibiotic therapy is often ineffective and thus recent attention has focused on vaccine development. A systematic understanding of S. equi virulence, leading to the identification of targets to which protective immunity can be directed, is a prerequisite of the development of such a vaccine. Here, the virulence factors of S. equi are reviewed.
Harrington
Dean J
DJ
Department of Biomedical Sciences, University of Bradford, West Yorkshire, BD7 1DP, UK. d.harrington@bradford.ac.uk
Sutcliffe
Iain C
IC
Chanter
Neil
N
D000818:Animals; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006734:Horse Diseases / Q000382:microbiology*; D006736:Horses / Q000382:microbiology*; D013290:Streptococcal Infections / Q000382:microbiology* / Q000662:veterinary; D022541:Streptococcal Vaccines / Q000737:chemistry / Q000276:immunology; D018502:Streptococcus equi / Q000201:enzymology / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*; D014774:Virulence
D001426:Bacterial Proteins; D002352:Carrier Proteins; D022541:Streptococcal Vaccines