title: EUS in the diagnosis of early chronic pancreatitis: a prospective follow-up study.
abstract: BACKGROUND
  The aim of this prospective, follow-up study was to investigate the value of EUS in the diagnosis of alcohol-induced chronic pancreatitis.
  
  
  METHODS
  One hundred thirty patients with known (n = 51) or clinically suspected (n = 79) chronic pancreatitis were included. Patients with a history of chronic use of alcohol and recurrent abdominal pain underwent endoscopic retrograde pancreatography and EUS. The 38 patients with normal endoscopic retrograde pancreatography but signs of chronic pancreatitis on EUS were included in a follow-up program.
  
  
  RESULTS
  All patients with chronic pancreatitis confirmed by retrograde pancreatography (n = 92; 70.8%) had ductal or parenchymal changes detectable with EUS. Among 38 patients (29.2%) with normal retrograde pancreatography, 32 (84.2%) presented with morphologic features consistent with chronic pancreatitis by EUS. During follow-up (median 18 months, range 6-25 months) chronic pancreatitis was confirmed by repeat endoscopic retrograde pancreatography in 22 of these 32 patients (68.8%). On the basis of these follow-up data, the sensitivities of EUS and endoscopic retrograde pancreatography at the time of the first examination were, respectively, 100% and 80.7% (p < 0.001).
  
  
  CONCLUSIONS
  EUS detects chronic pancreatitis in all cases if endoscopic retrograde pancreatography was suggestive for chronic pancreatitis. However, EUS is more sensitive than endoscopic retrograde pancreatography in the detection of early morphologic changes of chronic pancreatitis in patients with abdominal pain and a history of chronic and continued ingestion of alcohol.
authors.affiliation: Department of Gastroenterology and the Department of Surgery, Otto-von-Guericke-University, Magdeburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kahl
authors.forename: Bernhard
authors.initials: B
authors.lastname: Glasbrenner
authors.forename: Andreas
authors.initials: A
authors.lastname: Leodolter
authors.forename: Matthias
authors.initials: M
authors.lastname: Pross
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Schulz
authors.forename: Peter
authors.initials: P
authors.lastname: Malfertheiner
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D019160:Endosonography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000000981:diagnostic imaging; D019512:Pancreatitis, Alcoholic / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D011859:Radiography