In vivo degradation and biocompatibility of a new class of alternate poly(ester-anhydrides) based on aliphatic and aromatic diacids.
The degradation, tissue compatibility, and toxicology of a novel class of alternate poly(ester-anhydrides) were assessed in rats. It was observed that the degradation rate of the polymers in vivo was slower than that in vitro. In addition, erosion and intact zone were observed for all the polymers. IR and SEM analysis of the outer erosion and inner intact zone revealed that the outer zone degraded more rapidly than the inner zone. Such results were similar to that in vitro. All the studied poly(ester-anhydrides) produced mild inflammatory reactions and tissue encapsulation by layers of fibroblastic cells in vivo. Observation of liver and kidney tissue by light microscopy suggested the hydrolytic products of the studied poly(ester-anhydrides) had no harmful effects on the normal tissue/organs. In addition, the polymer and the breakdown products were found to be non-mutagenic by examination of micronucleus in bone marrow.
Jiang
H L
HL
Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.
Tang
G P
GP
Weng
L H
LH
Zhu
K J
KJ
D020341:Absorbable Implants / Q000592:standards; D000812:Anhydrides; D000818:Animals; D001673:Biodegradation, Environmental; D003998:Dicarboxylic Acids; D005347:Fibroblasts; D007249:Inflammation / Q000139:chemically induced; D007700:Kinetics; D008422:Materials Testing; D048629:Micronuclei, Chromosome-Defective; D011091:Polyesters; D011108:Polymers / Q000493:pharmacokinetics* / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats
D000812:Anhydrides; D003998:Dicarboxylic Acids; D011091:Polyesters; D011108:Polymers