title: Increased incidence of affective disorders, anxiety disorders, and non-natural mortality in women after breast cancer diagnosis: a nation-wide cohort study in Denmark.
abstract: OBJECTIVE
  To investigate whether breast cancer patients have increased incidence of psychiatric admission with affective disorders, anxiety disorders, or non-natural mortality compared with the general female population.
  
  
  METHODS
  Register-linkage between nation-wide registries: The Danish Psychiatric Central Register, The Danish Cancer Registry, and The Danish National Register of Causes of Death. A total of 61 709 women registered with primary invasive breast cancer between 1970 and 1993 were included and 356 023 person-years were accrued.
  
  
  RESULTS
  The standardized incidence ratio of first-ever psychiatric admission with affective disorder was 1.49 (95% CI: 1.35-1.63) and with anxiety disorder 1.25 (95% CI: 1.06-1.46). The standardized non-natural mortality ratio during the first year after breast cancer diagnosis was 1.54 (95% CI: 1.27-1.87). All analyses were adjusted for age, calendar period, and place of residence.
  
  
  CONCLUSIONS
  Breast cancer patients have significantly increased incidence of psychiatric admission with affective disorders, anxiety disorders, and non-natural mortality.
authors.affiliation: Department of Psychiatry, Rigshospitalet University Hospital, Copenhagen, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Hjerl
authors.forename: E W
authors.initials: EW
authors.lastname: Andersen
authors.forename: N
authors.initials: N
authors.lastname: Keiding
authors.forename: P B
authors.initials: PB
authors.lastname: Mortensen
authors.forename: T
authors.initials: T
authors.lastname: Jørgensen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001008:Anxiety Disorders / Q000453:epidemiology*; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000401:mortality*; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D019964:Mood Disorders / Q000453:epidemiology*