Twin pregnancy using recombinant gonadotropins in a woman with hypogonadotropic hypogonadism.
In women with hypogonadotropic hypogonadism both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are required to induce optimal follicular growth and steroidogenesis. The development of molecular genetic technology has led to the availability of recombinant FSH and LH for the induction of follicular growth and ovulation. We describe a first case of a twin pregnancy in a 36-year-old patient presenting with primary hypogonadotropic amenorrhea and empty sella syndrome and treated with recombinant FSH and LH. This therapy led to the maturation of two follicles, both of which were fertilized. A twin pregnancy ensued and two normal infants were delivered.
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Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, L.go A Gemelli 8, 00168 Rome, Italy.
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D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000328:Adult; D002585:Cesarean Section; D004652:Empty Sella Syndrome / Q000150:complications; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007986:Luteinizing Hormone / Q000008:administration & dosage*; D008297:Male; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D006080:Ovarian Follicle / Q000502:physiology; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D011994:Recombinant Proteins / Q000008:administration & dosage; D014427:Twins
D000318:Adrenergic beta-Agonists; D011994:Recombinant Proteins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone