title: [Diagnostic strategy in persistent hyperparathyroidism. Report of two cases and review of the literature].
abstract: Ectopic adenoma is the main cause of surgery failure in the treatment of primary hyperparathyroidism (HPT). Localization of the abnormal glands is therefore necessary before a reoperation. We report two cases illustrating the interest of MRI and selective venous sampling of parathormone. In two patients with persistent hyperparathyroidism, ultrasound and sestamibi scanning failed to localize the ectopic glands. MRI suggested the presence of an adenoma in the mediastinum for the first patient and inside the thyroid for the second. In both cases, the localisation was confirmed by venous sampling and the reoperation was a success. We review the recent literature on this topic and we propose a diagnostic approach of persistent HPT.
authors.affiliation: Clinique Médicale B, Hôpital Bretonneau - CHRU de Tours, 37044 Tours Cedex 1, France.
authors.forename: L
authors.initials: L
authors.lastname: Morbois-Trabut
authors.forename: N
authors.initials: N
authors.lastname: Saad
authors.forename: N
authors.initials: N
authors.lastname: Gervaise
authors.forename: P
authors.initials: P
authors.lastname: Legmann
authors.forename: P
authors.initials: P
authors.lastname: Lecomte
mesh_terms: D000236:Adenoma / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D002404:Catheterization; D002828:Choristoma / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008477:Mediastinal Diseases / Q000175:diagnosis; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000175:diagnosis*; D013959:Thyroid Diseases / Q000175:diagnosis; D014680:Veins
chemical_list: D010281:Parathyroid Hormone
vernacular_title: Stratégie diagnostique devant une hyperparathyroïdie persistante.