title: Physical activity does not mitigate G-protein-related genetic risk for obesity in individuals of African descent.
abstract: The G-protein beta3 subunit 825 TT genotype has been associated with obesity and hypertension. We examined the interaction between the G-protein TT genotype, physical activity and body mass index (BMI) in a cross-sectional study of African immigrants and African Americans. The genotype frequencies were 6.3% CC, 37.7% CT, and 56% TT. After adjusting for potential confounders, BMI was found to be significantly higher in the sedentary than in the physically active participants (p=0.045). There was no statistically significant effect for genotype (p=0.215) or the interaction between genotype and the level of physical activity (p=0.219). However, the individuals with the CC or CT genotype who were physically active had substantially lower BMIs (M+/-SE) (i.e., 25.74+/-2.02) than any of the other groups: sedentary CC + CT (30.58+/-1.03), sedentary TT (30.65+/-1.00) or active TT (29.43+/-1.65). Because of the low statistical power of this study, further research is needed to confirm these findings and to explore potential gene-environment/lifestyle interactions.
authors.affiliation: Mid America Heart Institute and the University of Missouri-Kansas City, 64110, USA. postonwa@umkc.edu
authors.forename: W S C
authors.initials: WS
authors.lastname: Poston
authors.forename: C K
authors.initials: CK
authors.lastname: Haddock
authors.forename: J
authors.initials: J
authors.lastname: Spertus
authors.forename: D M
authors.initials: DM
authors.lastname: Catanese
authors.forename: V N
authors.initials: VN
authors.lastname: Pavlik
authors.forename: D J
authors.initials: DJ
authors.lastname: Hyman
authors.forename: C L
authors.initials: CL
authors.lastname: Hanis
authors.forename: J P
authors.initials: JP
authors.lastname: Forevt
mesh_terms: D000328:Adult; D044383:Black People / Q000235:genetics*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D015444:Exercise; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics*; D011795:Surveys and Questionnaires; D001741:Black or African American
chemical_list: D019204:GTP-Binding Proteins