PPARgamma2 pro12Ala polymorphism and insulin resistance in Japanese hypertensive patients.
We investigated the relationship between peroxisome proliferator-activated receptor gamma (PPARgamma) Pro12Ala substitution and insulin resistance in subjects with normal insulin secretory capacity, since it has been reported that PPARgamma may affect not only insulin resistance but also insulin secretion. We examined 81 Japanese male patients with untreated essential hypertension using the glucose clamp technique. We found 77 subjects with Pro/Pro and 4 subjects with Pro/Ala genotype, and the glucose disposal rate was not significantly different between the two groups. Fasting plasma glucose, fasting immunoreactive insulin, total cholesterol, HDL cholesterol, and triglyceride were not significantly different between the two groups. There were also no significant differences between groups in homeostasis model assessment of insulin resistance (HOMA-R) values, area under the curve (AUC) for plasma glucose, or AUC for IRI in 75 g OGTT. Because insulin sensitivity is likely to be determined by polygenic factors, we also investigated beta3 adrenergic receptor Trp64Arg polymorphism as a possible determinant of insulin resistance. In conclusion, no significant association was observed between PPARgamma2 substitution and insulin sensitivity in the present cohort of Japanese hypertensive patients.
Yamamoto
Junko
J
Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Kageyama
Shigeru
S
Nemoto
Masami
M
Sasaki
Takashi
T
Sakurai
Tatsuya
T
Ishibashi
Ken-ichi
K
Mimura
Akira
A
Yokota
Kuninobu
K
Tajima
Naoko
N
D000328:Adult; D000409:Alanine; D000483:Alleles; D019943:Amino Acid Substitution; D001120:Arginine; D044466:Asian People / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology*; D007333:Insulin Resistance / Q000235:genetics*; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011392:Proline; D011943:Receptors, Adrenergic, beta / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D014364:Tryptophan
D011943:Receptors, Adrenergic, beta; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D014364:Tryptophan; D001120:Arginine; D011392:Proline; D000409:Alanine