Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent.
Epigallocatechin-3-gallate (EGCG), one of the components of green tea, has been suggested to have antiviral activity. To determine the effects of EGCG on HIV infection, peripheral blood lymphocytes were incubated with either LAI/IIIB or Bal HIV strains and increasing concentrations of EGCG. EGCG strongly inhibited the replication of both virus strains as determined by reverse transcriptase and p24 assays on the cell supernatants.
Fassina
Gianfranco
G
Instituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
Buffa
Anna
A
Benelli
Roberto
R
Varnier
Oliviero E
OE
Noonan
Douglas M
DM
Albini
Adriana
A
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D002392:Catechin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000166:cytology; D013662:Tea / Q000737:chemistry*
D019380:Anti-HIV Agents; D000975:Antioxidants; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate; D054303:HIV Reverse Transcriptase