title: Equal plasma viral loads predict a similar rate of CD4+ T cell decline in human immunodeficiency virus (HIV) type 1- and HIV-2-infected individuals from Senegal, West Africa.
abstract: Human immunodeficiency virus (HIV) type 2 infection is characterized by slower disease progression to acquired immunodeficiency syndrome than results from HIV-1 infection. To better understand the biological factors underlying the different natural histories of infection with these 2 retroviruses, we examined the relationship between HIV RNA and DNA levels and the rate of CD4(+) T cell decline among 472 HIV-1- and 114 HIV-2-infected individuals from Senegal. The annual rate of CD4(+) T cell decline in the HIV-2 cohort was approximately one-fourth that seen in the HIV-1 cohort. However, when the analysis was adjusted for baseline plasma HIV RNA level, the rates of CD4(+) T cell decline per year for the HIV-1 and HIV-2 cohorts were similar (a rate increase of approximately 4% per year for each increase in viral load of 1 log(10) copies/mL). Therefore, plasma HIV load is predictive of the rate of CD4(+) T cell decline over time, and the correlation between viral load and the rate of decline appears to be similar among all HIV-infected individuals, regardless of whether they harbor HIV-1 or HIV-2.
authors.affiliation: Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98103, USA.
authors.forename: Geoffrey S
authors.initials: GS
authors.lastname: Gottlieb
authors.forename: Papa Salif
authors.initials: PS
authors.lastname: Sow
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Hawes
authors.forename: Ibra
authors.initials: I
authors.lastname: Ndoye
authors.forename: Mary
authors.initials: M
authors.lastname: Redman
authors.forename: Awa M
authors.initials: AM
authors.lastname: Coll-Seck
authors.forename: Mame A
authors.initials: MA
authors.lastname: Faye-Niang
authors.forename: Aissatou
authors.initials: A
authors.lastname: Diop
authors.forename: Jane M
authors.initials: JM
authors.lastname: Kuypers
authors.forename: Cathy W
authors.initials: CW
authors.lastname: Critchlow
authors.forename: Richard
authors.initials: R
authors.lastname: Respess
authors.forename: James I
authors.initials: JI
authors.lastname: Mullins
authors.forename: Nancy B
authors.initials: NB
authors.lastname: Kiviat
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D004279:DNA, Viral / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D015498:HIV-2 / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000097:blood; D012675:Senegal; D019562:Viral Load; D014766:Viremia / Q000821:virology
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral