title: [Discoloration of teeth by drugs].
abstract: Since 1979 the Dutch Centre for Monitoring of Adverse Reactions to Drugs received 37 reports of tooth discoloration, attributed to the use of drugs. It concerned sixteen males and 21 females with an average age of respectively twelve and 26 years. Most cases were attributed to the use of amoxicillin (n = 16) and doxycycline or minocycline (n = 7). Pseudo-discolorations are chiefly caused by antimicrobial agents, possibly by chromogenic precipitates in the pellicle or by overgrowth with chromogenic micro-organisms.
authors.affiliation: Bureau Bijwerkingen Geneesmiddelen, Farmacotherapie, rijksuniversiteit te Utrecht.
authors.forename: M E
authors.initials: ME
authors.lastname: de Wit
authors.forename: B H
authors.initials: BH
authors.lastname: Stricker
authors.forename: A J
authors.initials: AJ
authors.lastname: Porsius
mesh_terms: D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004318:Doxycycline / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects; D009426:Netherlands / Q000453:epidemiology; D010406:Penicillins / Q000009:adverse effects*; D014075:Tooth Discoloration / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D000658:Amoxicillin; D008911:Minocycline; D004318:Doxycycline
vernacular_title: Meldingen van tandverkleuring door geneesmiddelen.