[Suppression of glutamate neurotoxicity by 5-HT in hippocampal neurons].
The effects of excess glutamate on the survival rate of cultured hippocampal neurons, the population spike (PS) of CA1 area of hippocampal slices and the Ca(2+) current of hippocampal neurons were observed in rats. Decreased survival rate of hippocampal neurons in the presence of excess glutamate was partially reversed by 5-HT, which was in association with a less decrease of PS magnitudes. The Ca(2+) inward current induced by glutamate was significantly diminished in the presence of 5-HT. It is suggested that 5-HT can inhibit excess glutamate-induced neurotoxicity by suppressing the glutamate triggered calcium influx.
Ma
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Institute of Health and Environmental Medicine, Tianjin 300050. maqiangw@sina.com
Liu
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Wu
L Y
LY
Chao
F H
FH
D000818:Animals; D000831:Animals, Newborn; D015220:Calcium Channels / Q000187:drug effects; D002470:Cell Survival; D002478:Cells, Cultured; D003864:Depression, Chemical; D018698:Glutamic Acid / Q000633:toxicity*; D006624:Hippocampus / Q000166:cytology*; D009474:Neurons / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology*
D015220:Calcium Channels; D012701:Serotonin; D018698:Glutamic Acid