title: The preliminary evaluation of HAP + TCP composite material biodegradation after implantation in muscular tissue of rats.
abstract: Ceramic biomaterials based on calcium phosphates have a special position among modern implantation material in osteosurgery. Non-reabsorbable hydroxyapatite (HAP) and reabsorbable tricalcium phosphate are the most popular calcium phosphate ceramics. The appropriate ratio of these two compounds should result in forming the gradually reabsorbable implants, overgrowing with the bone tissue which mechanical strength should not be negatively affected. The aim of this work was to evaluate a local tissue reaction and the HAP + TCP composite resorption rate as compared with HAP, after implantation in a muscle tissue of rats. On the basis of carried macroscopic and microscopic evaluations, it can be stated that the new HAP + TCP composite had high biocompatibility and were gradually reabsorbed. This enables faster overgrowing the implant with tissue.
authors.affiliation: Department of Experimental Surgery, Biomaterials Research Medical Academy of Wrocław.
authors.forename: Z
authors.initials: Z
authors.lastname: Domagała
authors.forename: J
authors.initials: J
authors.lastname: Sliwa
authors.forename: E
authors.initials: E
authors.lastname: Hajek
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D018786:Bone Substitutes; D002130:Calcium Phosphates / Q000032:analysis; D006882:Hydroxyapatites / Q000032:analysis; D008422:Materials Testing; D018482:Muscle, Skeletal / Q000473:pathology / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C094280:hydroxyapatite-tricalciumphosphate composite