title: The potential economic consequences of cognitive improvement with losartan.
abstract: In a clinical trial, treatment of mild-moderate hypertensive patients with losartan (50 mg) increased Mini-Mental State Examination (MMSE) scores by 4 points from baseline over a 26-month period, compared with a 1-point increase in patients treated with hydrochlorothiazide (25 mg). This study explores the potential economic consequences of this improvement in cognitive function in a population of elderly hypertensive patients in Sweden. Resource use and MMSE data for 437 hypertensive, non-demented subjects aged 75 years and above, were taken from a population-based study in Sweden. MMSE scores were strongly related with costs of care due to higher utilization of home help and special living arrangements in patients with low scores. A 1-point difference in MMSE was associated with a difference in the annual cost of care of approximately 5700 Swedish kronor (SEK). Over 26 months, the potential cost savings from the 4-point improvement observed with losartan was estimated to be between 24700 and 43700 SEK. This can be compared with the acquisition cost of losartan; approximately 5700 SEK over the study period. Thus, an improvement in cognitive function of the magnitude documented in the study of losartan vs hydrochlorothiazide, may translate into economic benefits beyond those expected in terms of blood pressure control.
authors.affiliation: Department of Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC), Karolinska Institutet, Stockholm, Sweden. linus.j@healtheconomics.se
authors.forename: Linus
authors.initials: L
authors.lastname: Jönsson
authors.forename: William
authors.initials: W
authors.lastname: Gerth
authors.forename: Johan
authors.initials: J
authors.lastname: Fastbom
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000191:economics / Q000494:pharmacology* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy / Q000191:economics / Q000517:prevention & control*; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology; D007361:Intelligence Tests; D019808:Losartan / Q000191:economics* / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013548:Sweden / Q000453:epidemiology
chemical_list: D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D019808:Losartan