title: [Kinetic effect of testosterone or estradiol on iodine absorption in castrating rat intestine].
abstract: OBJECTIVE
  To observe the effect of testosterone or estradiol on iodine absorption in rat intestine.
  
  
  METHODS
  50 male adult Wistar rats were divided into 5 groups randomly. 50 females were divided into another 5 groups. Among them, 4 groups were bilaterally testectomized or ovariectomized, 1 group was sham-operated. 7 days after operation, the castrated rats received testosterone (male rats) or estradiol (female rats) at different dosages by intramuscular injection for three days. Then the kinetics of iodine absorption in jejunum and ileum were observed by perfusion in situ. When finished, serum were obtained for detecting TSH, T4 and testosterone or estradiol.
  
  
  RESULTS
  In castrated male rats, the value of K12 reduced, K21 increased, K02 reduced, and SP1/2 (the half time of the slow phase) prolonged, implying that the ability of iodine absorption reduced. It reflected that testosterone could promote iodine absorption in intestine in physiological condition. In castrated female rats, the situation was different from that in male rats, the value of K12 increased, K21 reduced, K02 increased, and SP1/2 shortened in jejunum, implying that the ability of iodine absorption increased. It reflected that estradiol could inhibit iodine absorption in intestine in physiological condition. The levels of serum TSH and T4 were not changed significantly in this experiment.
  
  
  CONCLUSIONS
  In physiological condition, testosterone can promote iodine absorption, while estradiol has the inhibiting effect. The results indicate that gonadol hormone maybe one factor which can influence iodine absorption in intestine. It may explain the phenomenon that the incidence of goiter is different between males and females partly.
authors.affiliation: Institute of Child and Adolescent Health, Beijing Medical University, Beijing 100083, China.
authors.forename: N
authors.initials: N
authors.lastname: Wu
authors.forename: G
authors.initials: G
authors.lastname: Ye
authors.forename: Z
authors.initials: Z
authors.lastname: Tang
mesh_terms: D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007408:Intestinal Absorption; D007455:Iodine / Q000493:pharmacokinetics*; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone; D004958:Estradiol; D007455:Iodine