title: A novel antibiotic CJ-17,572 from a fungus, Pezicula sp.
abstract: A new antibiotic, CJ-17,572 (I) was isolated from the fermentation broth of a fungus Pezicula sp. CL11877. The structure of I was determined to be a new equisetin derivative by spectroscopic analyses. The compound inhibits the growth of multi-drug resistant Staphylococcus aureus and Enterococcusfaecalis with IC50s of 10 and 20 microg/ml, respectively.
authors.affiliation: Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. Yutaka.Sugie@japan.pfizer.com
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sugie
authors.forename: Koen A
authors.initials: KA
authors.lastname: Dekker
authors.forename: Taisuke
authors.initials: T
authors.lastname: Inagaki
authors.forename: Yoon-Jeong
authors.initials: YJ
authors.lastname: Kim
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Sakakibara
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sakemi
authors.forename: Akemi
authors.initials: A
authors.lastname: Sugiura
authors.forename: Lori
authors.initials: L
authors.lastname: Brennan
authors.forename: Joan
authors.initials: J
authors.lastname: Duignan
authors.forename: Joyce A
authors.initials: JA
authors.lastname: Sutcliffe
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kojima
mesh_terms: D000107:Acetylation; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D011760:Pyrrolidinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; C451491:CJ 17572; D011760:Pyrrolidinones; D013764:Tetrahydronaphthalenes