title: Papanicolaou tests diagnosed as atypical by a cytotechnologist and downgraded to benign by a pathologist: a measure of laboratory quality.
abstract: Follow-up of Papanicolaou (Pap) tests diagnosed as atypical squamous cells of undetermined significance (ASCUS) or atypical glandular cells of undetermined significance (AGUS) by a cytotechnologist and downgraded to benign by a pathologist has not been measured. Squamous intraepithelial lesion (SIL) follow-up rates were obtained for Pap tests diagnosed as ASCUS (288) or AGUS (94) and downgraded to benign and for Pap tests diagnosed as repair (231). Statistically significant associations were seen between 7 cytotechnologists and between 7 pathologists and ASCUS, AGUS, downgraded ASCUS, and downgraded AGUS rates. The percentage of downgraded ASCUS cases compared with all ASCUS cases per pathologist ranged from 4.8% to 43.7%. Statistically significant associations between pathologists and SIL follow-up rates for downgraded ASCUS diagnoses were seen. The SIL follow-up rate for repair (7.9%) was similar to that for a downgraded ASCUS (11.0%) or AGUS (7.3%). The parameters of downgraded ASCU and AGUS Pap test interpretations are good quality indicators of individual performance and overall laboratory quality.
authors.affiliation: Department of Pathology and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Condel
authors.forename: Laura K
authors.initials: LK
authors.lastname: Mahood
authors.forename: Dana M
authors.initials: DM
authors.lastname: Grzybicki
authors.forename: Charles D
authors.initials: CD
authors.lastname: Sturgis
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Raab
mesh_terms: D003585:Cell Biology; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D006801:Humans; D017056:Medical Laboratory Personnel; D015588:Observer Variation; D065006:Papanicolaou Test; D010336:Pathology; D011786:Quality Control; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology; D014626:Vaginal Smears / Q000592:standards*; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000473:pathology