title: Functional integration of adult-born neurons.
abstract: Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be resolved. Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.
authors.affiliation: Department of Cell and Molecular Biology, Medical Nobel Institute, Stockholm, Sweden.
authors.forename: Marie
authors.initials: M
authors.lastname: Carlén
authors.forename: Robert M
authors.initials: RM
authors.lastname: Cassidy
authors.forename: Hjalmar
authors.initials: H
authors.lastname: Brismar
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Smith
authors.forename: Lynn W
authors.initials: LW
authors.lastname: Enquist
authors.forename: Jonas
authors.initials: J
authors.lastname: Frisén
mesh_terms: D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation; D002772:Cholera Toxin / Q000378:metabolism; D018891:Dentate Gyrus / Q000166:cytology; D011558:Herpesvirus 1, Suid / Q000502:physiology; D006624:Hippocampus / Q000166:cytology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000502:physiology* / Q000821:virology; D009830:Olfactory Bulb / Q000166:cytology* / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology* / Q000821:virology; D013569:Synapses / Q000378:metabolism / Q000821:virology
chemical_list: D015415:Biomarkers; D016760:Proto-Oncogene Proteins c-fos; D002772:Cholera Toxin