title: A laboratory model of testing shunt performance after implantation.
abstract: Constant rate infusion tests are used clinically to test shunt function in vivo in hydrocephalic patients. The criteria for appropriate shunt function have never been validated in the laboratory. Nine of the most commonly used types of hydrocephalus valves construction were selected and tested in a model of the CSF circulation incorporating increased resistance to CSF outflow [24 mmHg/(ml/min)] and decreased hydrodynamic compliance (<2 ml/mmHg), that are typical conditions in hydrocephalus. The aim was to document the pressure response to constant rate infusion of a model of CSF circulation with different valves and to define which measures are useful in shunt testing in vivo. The pressure-course of simulated CSF pressure was established and proved to be equivalent to clinical results. The baseline CSF pressure failed to correlate with shunt operating pressure for medium pressure valves (R = 0.14, p > 0.05). End-equilibrium pressure recorded during infusion correlated strongly with the opening pressure (R = 0.94, p = 0.0001) and the shunt's resistance (R = 0.86, p = 0.0026). The infusion test is able to assess shunt function. End-equilibrium pressure recorded during the test has been confirmed to correlate with the shunt's performance.
authors.affiliation: Academic Neurosurgical Unit, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: R
authors.initials: R
authors.lastname: Taylor
authors.forename: Z
authors.initials: Z
authors.lastname: Czosnyka
authors.forename: M
authors.initials: M
authors.lastname: Czosnyka
authors.forename: J D
authors.initials: JD
authors.lastname: Pickard
mesh_terms: D015170:Cerebrospinal Fluid Pressure; D002557:Cerebrospinal Fluid Shunts; D004867:Equipment Design; D004868:Equipment Failure; D006801:Humans; D006849:Hydrocephalus / Q000503:physiopathology / Q000601:surgery*; D008422:Materials Testing / Q000379:methods*; D008959:Models, Neurological