Broadly effective enantioselective Diels-Alder reactions of 1-amino-substituted-1,3-butadienes.
[reaction: see text] A broad range of substituted 1-amino-1,3-butadienes undergo enantioselective Diels-Alder reactions with methacrolein in the presence of 5 mol % of Cr(III)-salen complex 1. The reactions are carried out conveniently, at room temperature, and they afford the cycloadducts in high yields and excellent ee's.
Huang
Yong
Y
Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.
Iwama
Tetsuo
T
Rawal
Viresh H
VH
D002070:Butadienes / Q000138:chemical synthesis*; D003500:Cyclization; D007202:Indicators and Reagents; D013237:Stereoisomerism; D013696:Temperature
D002070:Butadienes; D007202:Indicators and Reagents