Neuroepithelial origin of the insular and endopiriform parts of the claustrum.
The lateral and ventral pallia have been proposed as the source of neurons for the insular and endopiriform claustra, respectively. However, this correlation is controversial. Here, we analysed this relationship by labelling radial glia in coronal slices of the telencephalon of paraformaldehyde-fixed rabbit embryos (E18-E28) and newborn rabbits with an anti-vimentin antibody or with the fluorescent dye DiI. The radial glia that crossed the claustrum was anchored to the neuroepithelium of the lateral ventricular angle (LVA) at all ages studied. The LVA was deep at E18, but it subsequently become shallower, because of the apposition of the portion of its walls proximal to the vertex of the LVA. At E18, the radial glia that crossed most of the insular claustrum extended from the lateral wall of the LVA (presumptive lateral pallium), and the radial glia that crossed either the most ventral part of the insular claustrum or the endopiriform claustrum proceeded from the medial wall of the LVA (presumptive ventral pallium). These results suggest that although the endopiriform claustrum originates from the ventral pallium, the insular claustrum originates from both the lateral and the ventral pallial portions.
Reblet
Concepción
C
Department of Neurosciences, School of Medicine and Dentistry, The University of the Basque Country, Leioa, Spain. onpreloc@lg.ehu.es
Alejo
A
A
Blanco-Santiago
R I
RI
Mendizabal-Zubiaga
J
J
Fuentes
M
M
Bueno-López
J L
JL
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001479:Basal Ganglia / Q000196:embryology* / Q000254:growth & development*; D002465:Cell Movement; D004622:Embryo, Mammalian / Q000166:cytology / Q000502:physiology; D009457:Neuroglia / Q000502:physiology; D009474:Neurons / Q000502:physiology; D011817:Rabbits; D013687:Telencephalon / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D014746:Vimentin / Q000378:metabolism
D014746:Vimentin