Mucoadhesive polymers with immobilized proteinase inhibitors for oral administration of protein drugs.
A new approach to overcome the degradation of protein drugs by proteolytic enzymes and their targeting to the blood through the digestive apparatus was developed. The approach is based on the immobilization of drugs into the polymeric hydrogel containing glycoprotein--ovomucoid from duck egg whites. This glycoprotein inhibits the activity of proteolytic enzymes and acts as a biospecific ligand to lectins on the walls of the gastrointestinal tract.
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A. V. Topchiev Institute of Institute of Petrochemical Synthesis Laboratory, Russian Academy of Sciences, Moscow.
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Sytov
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D000284:Administration, Oral; D000818:Animals; D001672:Biocompatible Materials; D016503:Drug Delivery Systems; D004372:Ducks; D004529:Egg White; D005753:Gastric Mucosa / Q000473:pathology*; D005947:Glucose / Q000378:metabolism; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007328:Insulin / Q000378:metabolism; D007700:Kinetics; D008024:Ligands; D010059:Ovomucin / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011134:Polysaccharides / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013997:Time Factors; D014867:Water
D001672:Biocompatible Materials; D007328:Insulin; D008024:Ligands; D011108:Polymers; D011134:Polysaccharides; D014867:Water; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010059:Ovomucin; D005947:Glucose