[The protective effects of nerve growth factor on peripheral nerve injury].
The protective effects of nerve growth factor (NGF) on peripheral nerve injury and sensory neuron growth were studied in three models: peripheral sympathetic nerve injury induced by intraperitoneal injection of 6-hydrodopamine (6-OHDA), mechanically injured ulnar nerve and cultured dorsal root ganglion (DRG) of newborn rats in vitro. The results indicate that NGF dose-dependently increased norepinephrine content in mouse submandibular gland and cell numbers of C7 (seventh cervical vertebra), T1 (first thoracic vertebra) dorsal root ganglion in rabbits, and also dramatically promoted the growth of neuronal projections in cultured DRG. These results suggest that NGF has significant neuroprotective action in peripheral nerve injury and a strong neuronutrition on sensory neuron.
Wu
J
J
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050.
Qu
Z
Z
Wei
G
G
Zhang
J
J
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D005260:Female; D005727:Ganglia, Spinal / Q000166:cytology*; D008297:Male; D051379:Mice; D020932:Nerve Growth Factor / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine; D010525:Peripheral Nerves / Q000187:drug effects / Q000473:pathology*; D011817:Rabbits; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism
D018696:Neuroprotective Agents; D016627:Oxidopamine; D020932:Nerve Growth Factor; D009638:Norepinephrine