[The effect of dopamine on serum lipid concentration after propofol administration].
Propofol in emulsion formulation is widely used for operation and sedation in ICU. We retrospectively investigated the effect of dopamine on post-operative serum lipid concentrations after propofol administration. Twenty three patients with ASA physical status I or II scheduled for elective operations were enrolled in this study; 15 patients in the non-dopamine administration group (Group P) and 8 patients in the dopamine administration group (Group Dopa-P). We measured triglyceride (TG), total cholesterol (T-chol) pre-operatively, post-operatively and on post-operative day 1 and AST, ALT preoperatively and on post-operative day 1. Serum TG concentration increased significantly in post-operative measurements in Group-P (P < 0.05). But there was no significant change in TG in Group Dopa-P. Serum T-chol concentration decreased significantly post-operatively and on post-operative day 1 in both groups (P < 0.05). Serum AST and ALT concentrations increased significantly on post-operative day 1 (P < 0.05). With 10% fat infusion rates below 0.1 mg.kg-1.hr-1 (equal to propofol 10 mg.kg-1.hr-1), serum lipid concentration did not increase. But our results suggest that the serum TG concentration may increase significantly post-operatively after intra-operative propofol administration and dopamine may decrease serum TG level.
Kimura
Takashi
T
Department of Intensive Care Unit, Kanagawa Prefectural Cancer Center, Yokohama 241-0815.
Hasegawa
Mamoru
M
Takano
Osami
O
D002784:Cholesterol / Q000097:blood; D004298:Dopamine / Q000494:pharmacology*; D005217:Fat Emulsions, Intravenous; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008055:Lipids / Q000097:blood*; D015742:Propofol / Q000008:administration & dosage*; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood
D005217:Fat Emulsions, Intravenous; D006993:Hypnotics and Sedatives; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D004298:Dopamine; D015742:Propofol