title: Radiofrequency thermal ablation of hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is one of the major malignancies worldwide. Due to advanced or decompensated liver cirrhosis, comorbidity and multicentricity of the tumor lesions, 70-80% of HCC patients are inoperable at the time of diagnosis. Radiofrequency thermal ablation (RFTA) is a new minimally invasive and sage technique for the nonsurgical treatment of HCCs. Similar to other ablation techniques, the treatment strategy depends on several factors, including the patient's clinical status, the stage of liver cirrhosis and of the HCC. RFTA can be performed percutaneously, laparoscopically or after laparotomy. Advanced RFTA equipment, refined techniques of modifying tumor tissue response to RFTA, and combined treatment strategies should lead to better response rates even in larger HCCs.
authors.affiliation: Department of Medicine II, University Hospital Freiburg, Germany. allgaier@medizin.ukl.uni-freiburg.de
authors.forename: H P
authors.initials: HP
authors.lastname: Allgaier
authors.forename: D
authors.initials: D
authors.lastname: Galandi
authors.forename: I
authors.initials: I
authors.lastname: Zuber
authors.forename: H E
authors.initials: HE
authors.lastname: Blum
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D017115:Catheter Ablation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D003131:Combined Modality Therapy; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000601:surgery*; D009367:Neoplasm Staging; D011379:Prognosis