title: Manic depressive psychosis and schizophrenia are neurological disorders at the extremes of CNS maturation and nutritional disorders associated with a deficit in marine fat.
abstract: The maturational theory of brain development comprises manic depressive psychosis and schizophrenia. It holds that the disorders are part of human diversity in growth and maturation, which explains their ubiquity, shared susceptibility genes and multifactorial inheritance. Rate of maturation and age at puberty are the genotype; the disorders are localized at the extremes with normality in between. This is based on the association between onset of puberty and the final regressive event, with pruning of 40% of excitatory synapses leaving the inhibitory ones fairly unchanged. This makes excitability, a fundamental property of nervous tissue, a distinguishing factor: the earlier puberty, the greater excitability--the later puberty, the greater deficit. Biological treatment supports deviation from the norm: neuroleptics are convulsant; antidepressives are anti-epiletogenic. There is an association between onset of puberty and body-build: early maturers are pyknic broad-built, late ones linearly leptosomic. This discrepancy is similar to that in the two disorders, supporting the theory that body-build is the phenotype. Standard of living is the environmental factor, which affects pubertal age and shifts the panorama of mental illness accordingly. Unnatural death has increased with antipsychotics. Other treatment is needed. PUFA deficit has been observed in RBC in both disorders and striking improvements with addition of minor amounts of PUFA. This supports that dietary deficit might cause psychotic development and that prevention is possible. Other neurological disorders also profit from PUFA, underlining a general deficit in the diet.
authors.affiliation: Department of Anatomy, Institute for Basic Medical Sciences, University of Oslo, Norway.
authors.forename: L F
authors.initials: LF
authors.lastname: Saugstad
mesh_terms: D005075:Biological Evolution; D001714:Bipolar Disorder / Q000209:etiology*; D002490:Central Nervous System / Q000254:growth & development; D004041:Dietary Fats / Q000008:administration & dosage; D005314:Embryonic and Fetal Development; D005260:Female; D006801:Humans; D007223:Infant; D007859:Learning Disabilities / Q000209:etiology; D008297:Male; D001523:Mental Disorders / Q000209:etiology; D008959:Models, Neurological; D009748:Nutrition Disorders / Q000209:etiology; D011627:Puberty; D012098:Reproduction; D012559:Schizophrenia / Q000209:etiology*; D012959:Socioeconomic Factors; D013398:Sudden Infant Death / Q000209:etiology
chemical_list: D004041:Dietary Fats