Treatment of severe chronic oral erosive lesions with clobetasol propionate in aqueous solution.
OBJECTIVE
We sought to analyze the results of topical treatment with a mouthwash of 0.05% clobetasol in aqueous solution in 30 patients with severe oral erosive lesions.


METHODS
Over a 48-week period, we evaluated the evolution of pain, ulcerations, atrophy, and interference of the disease in the patient's daily life, classifying the response as complete (100% remission/recovery), excellent (75%), good (50%), poor (<50%), or failed.


RESULTS
The pain and ulceration totally disappeared in 93.3% of cases and 90% reported a full recovery in their daily life activities. Atrophy response was complete in 28.5%, excellent in 60.7%, and good in 3.5%. Two patients showed no response to the treatment. Five patients suffered mild adverse effects (moon face and hirsutism) between week 4 and week 6 of treatment, which were speedily reversed by reducing the frequency of mouthwash.


CONCLUSIONS
Clobetasol mouthwash is a safe and efficacious option for the treatment of severe oral erosive lesions.
Gonzalez-Moles
Miguel Angel
MA
Department of Oral Medicine, School of Dentistry, University of Granada, Spain. magonzal@ugr.es
Morales
Patricia
P
Rodriguez-Archilla
Alberto
A
Isabel
Isabel Ruiz-Avila
IR
Gonzalez-Moles
Salvador
S
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002990:Clobetasol / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D005938:Glucocorticoids; D006801:Humans; D017676:Lichen Planus, Oral / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009067:Mouthwashes / Q000008:administration & dosage*; D010390:Pemphigoid, Benign Mucous Membrane / Q000188:drug therapy*; D013281:Stomatitis, Aphthous / Q000188:drug therapy*; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D009067:Mouthwashes; D002990:Clobetasol