Postprandial and short-term effects of dietary virgin olive oil on oxidant/antioxidant status.
It is generally believed that virgin olive oil consumption has beneficial effects, but little is known about its effects postprandially on oxidant/antioxidant status. The aim of this study was to determine changes in oxidative stress biomarkers and lipid profile after a single dose of virgin olive oil and after 1 wk of daily consumption. Sixteen subjects (9 men, 7 women) ingested 50 mL of virgin olive oil in a single dose. Blood samples were collected from 0 to 24 h. Thereafter, 14 participants (8 men, 6 women) followed a 1-wk 25 mg/d virgin olive oil dietary intervention. Blood samples were collected at the end of this period. Serum TAG (P = 0.016), plasma FA (P < 0.001), and lipid peroxidation products in plasma (P< 0.001) and VLDL (P = 0.007) increased, reaching a peak at 4-6 h, and returning to baseline values at 24 h after oil ingestion. The opposite changes were observed in plasma glutathione peroxidase (P = 0.001) and glutathione reductase (GR) (P = 0.042). No changes in LDL lipid peroxidation or resistance to oxidation were observed postprandially. At 24 h, plasma oleic acid remained increased (P < 0.05) and resistance of LDL to oxidation improved (P < 0.05). After 1 wk of virgin olive oil consumption, plasma oleic acid (P = 0.031), resistance of LDL to oxidation (P< 0.05), and plasma GR activity (P = 0.005) increased. These results indicate that changes in oxidant/antioxidant status occur after oral virgin olive oil. Virgin olive oil consumption could provide short-term benefits for LDL resistance to oxidation and in glutathione-related enzyme activities.
Fitó
Montserrat
M
Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Médica IMIM, Barcelona, Spain.
Gimeno
Eva
E
Covas
María-Isabel
MI
Miró
Elisabet
E
López-Sabater
Maria del Carmen
Mdel C
Farré
Magí
M
de
la Torre Rafael
lT
Marrugat
Jaume
J
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D016877:Oxidants / Q000097:blood*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology*; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D005227:Fatty Acids; D008077:Lipoproteins, LDL; D000069463:Olive Oil; D016877:Oxidants; D010938:Plant Oils; D014280:Triglycerides