Synthesis of some new antianemics I. Iron pullulan complexes of pharmaceutical interest.
First experiments were performed in order to obtain a polynuclear iron(III) complex with pullulan, which could be applied in therapy of sideropenic anemia. Complete synthesis of the complex can be realized with oligomers of depolymerized pullulan at an average molar mass 8000-10,000 g.mol-1. Maximum iron contents of 51.4 mg.cm-3 is effected by pullulan depolymerizates (Mw approximately 9000 g.mol-1, [eta] = 0.085 dl.g-1) at 130 degrees C for 240 min, at pH = 10.5 and at an initial mass ratio Fe/ligand of 1:3. The effected concentrations and complex stability respond to requirements of pharmacological application of parenteral antianemic preparations.
Nikolic
G
G
Faculty of Technology, University of Nish, Leskovac, Serbia, Yugoslavia.
Cakic
M
M
Ilic
Lj
Lj
Ristic
S
S
Cakic
Z
Z
D000740:Anemia / Q000188:drug therapy*; D002240:Carbohydrate Sequence; D005936:Glucans / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D007202:Indicators and Reagents; D007501:Iron / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D008024:Ligands; D008969:Molecular Sequence Data; D008970:Molecular Weight
D005936:Glucans; D007202:Indicators and Reagents; D008024:Ligands; C009109:pullulan; D007501:Iron