A novel cyclodextrin-derived tellurium compound with glutathione peroxidase activity.
A novel dicyclodextrinyl ditelluride (2-TeCD) compound was devised as a functional mimic of the glutathione peroxidase (GPX) enzymes that normally remove hydroperoxides from the cell. The GPX activity of the mimic was found to be 46.7 U microM(-1), which is 46 times as active as Ebselen, a well-known GPX mimic. A detailed steady-state kinetic study was undertaken to probe the reason for the high catalytic efficiency of 2-TeCD. This high efficiency can be explained based on both the binding of the substrate to the cyclodextrin and the catalytic mechanism of 2-TeCD, which is different from that of diselenide compounds. 2-TeCD exhibits good water solubility and is chemically and biologically stable. The biological effect of 2-TeCD was evaluated by its ability to protect mitochondria from oxidative damage. 2-TeCD exhibited excellent antioxidant capacity in comparison with Ebselen.
Ren
Xiaojun
X
Key Laboratory of Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun 130023, P.R. China.
Xue
Yan
Y
Liu
Junqiu
J
Zhang
Kun
K
Zheng
Jian
J
Luo
Guimin
G
Guo
Canhui
C
Mu
Ying
Y
Shen
Jiacong
J
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002417:Cattle; D003505:Cyclodextrins / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects; D008929:Mitochondria, Heart / Q000187:drug effects*; D013691:Tellurium / Q000737:chemistry* / Q000494:pharmacology
D000975:Antioxidants; D003505:Cyclodextrins; D005979:Glutathione Peroxidase; D013691:Tellurium