title: Higher acyclic nitrogen containing deoxy sugar derivatives: a new lead in the generation of antimycobacterial chemotherapeutics.
abstract: Syntheses of higher acyclic nitrogen containing deoxy sugar derivatives via nitroaldol reaction of different nitroalkanes with 2,3-dideoxy-alpha,beta-unsaturated aldehydo sugars obtained from glycals namely acetylated glucal and galactal and their in vitro antimycobacterial activity are presented.
authors.affiliation: Medicinal Chemistry Division, Central Drug Research Institute, -226001, Lucknow, India.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Pathak
authors.forename: Arun K
authors.initials: AK
authors.lastname: Shaw
authors.forename: Amiya P
authors.initials: AP
authors.lastname: Bhaduri
authors.forename: K V G
authors.initials: KV
authors.lastname: Chandrasekhar
authors.forename: Anil
authors.initials: A
authors.lastname: Srivastava
authors.forename: Kishore K
authors.initials: KK
authors.lastname: Srivastava
authors.forename: Vineeta
authors.initials: V
authors.lastname: Chaturvedi
authors.forename: Ranjana
authors.initials: R
authors.lastname: Srivastava
authors.forename: Brahm S
authors.initials: BS
authors.lastname: Srivastava
authors.forename: Shalini
authors.initials: S
authors.lastname: Arora
authors.forename: Sudhir
authors.initials: S
authors.lastname: Sinha
mesh_terms: D000107:Acetylation; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003837:Deoxy Sugars / Q000737:chemistry* / Q000494:pharmacology*; D006865:Hydrogenation; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000254:growth & development; D009584:Nitrogen / Q000032:analysis*; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D003837:Deoxy Sugars; D009584:Nitrogen