[Genomic approach to allergic diseases: present and future perspectives].
The rapid advances in genomic research have a major impact on biomedical sciences. In this review the authors summarize the current results of the genomic investigation of allergic diseases. From a genetic point of view allergy is multifactorial, which means that the susceptibility to the disease is determined by interactions between multiple genes, and involve important nongenetic factors such as the environment for their expression. There are two widespread methods for searching for disease susceptibility genes in allergy: (1) genome-wide search and (2) candidate gene association studies. Until now five groups have completed genome-wide searches for asthma, and almost 500 genetic linkage and association studies have reported more than 500 atopy and asthma loci throughout the genome. In this review we selected those results, which were consistently confirmed by several independent studies, or appeared particularly important, or interesting. On the basis of this, 9 chromosome regions can be associated with the susceptibility to allergic diseases: 2q, 5q31-q33, 6p21.3, 7q31, 11q13, 12q14.3-q24.31, 14q11.2-q13, 16p21, 17q11.2. According to the results of the human genome programs, and association studies, the authors discuss the possible roles of candidate genes found in these loci in the pathomechanism of allergy. Besides, the authors summarize briefly the results of pharmacogenomics, and animal linkage and genetics studies related to allergy.
Szalai
Csaba
C
Molekuláris Immunológiai Kutatócsoport, MTA-Semmelweis Egyetem, Budapest.
Kozma
Gergely Tibor
GT
Nagy
Adrienne
A
Bojszkó
Agnes
A
Falus
András
A
D000818:Animals; D002877:Chromosomes, Human / Q000235:genetics*; D004195:Disease Models, Animal; D030342:Genetic Diseases, Inborn / Q000235:genetics; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D010597:Pharmacogenetics; D009626:Terminology as Topic
Az allergiás megbetegedések genomikai megközelítése; lehetóségek és távlatok.