title: Radiotherapy alone in the treatment of clinical stage I-IIA, nonbulky, Hodgkin's disease: single-institution experience on 73 patients staged with lymphangiography and laparoscopy.
abstract: From 1985 to 1998, at the Regional Cancer Center of Padua, patients with Hodgkin's disease (HD) routinely underwent a clinical staging procedure including lymphangiography and laparoscopy with multiple liver and spleen biopsies. Patients with IA and IIA nonbulky HD were treated with radiotherapy alone. The aim of this study is to analyze the efficacy of radiotherapy as radical treatment in this group of patients, and the role of lymphangiography and laparoscopy in the selection of patients with abdominal disease located to the spleen, liver, or the pelvic lymphatic chains. From January 1985 to January 1998, 94 previously untreated patients with biopsy-proven HD underwent clinical staging procedures consisting of history, physical examination, routine laboratory tests, chest radiography, total-body computed tomography scan, and bone marrow biopsy and were considered in stage I-IIA nonbulky. In addition, all patients underwent bipedal lymphangiography, which was positive in 12 (12.8%). Of the 82 patients with negative lymphangiography, 9 (11%) showed disease below the diaphragm at laparoscopy with multiple random spleen and liver biopsies. Of the remaining 73 patients, 32 were male and 41 were female with a median age of 29 years (range: 14-72 years).
authors.affiliation: Department of Radiotherapy and Nuclear Medicine, Azienda Ospedaliera di Padova, Padova, Italy.
authors.forename: Renzo
authors.initials: R
authors.lastname: Mazzarotto
authors.forename: Caterina
authors.initials: C
authors.lastname: Boso
authors.forename: Giovanni
authors.initials: G
authors.lastname: Scarzello
authors.forename: Domenico
authors.initials: D
authors.lastname: Rubello
authors.forename: Dario
authors.initials: D
authors.lastname: Casara
authors.forename: Savina
authors.initials: S
authors.lastname: Aversa
authors.forename: Vanna
authors.initials: V
authors.lastname: Chiarion-Sileni
authors.forename: Silvio
authors.initials: S
authors.lastname: Monfardini
authors.forename: Guido
authors.initials: G
authors.lastname: Sotti
mesh_terms: D000008:Abdominal Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology* / Q000532:radiotherapy*; D006801:Humans; D010535:Laparoscopy; D008099:Liver / Q000473:pathology; D015182:Lymphatic Irradiation; D008220:Lymphography; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D013154:Spleen / Q000473:pathology