title: An algorithm for monitoring phenytoin therapy.
abstract: Nurse practitioners need an evidence-based framework for monitoring clients on phenytoin (Dilantin) therapy. A Med-line search of published literature and a synthesis of 10 years of research was performed. The effect of phenytoin within the body is dependent on the amount of serum albumin and the functional status of the major organs in the body. The basic principles of pharmacotherapeutics holds true for phenytoin. Closer investigation of total serum phenytoin and serum albumin ratio by primary care providers is necessary for monitoring therapeutic levels of phenytoin therapy. An algorithm was developed to provide a quick reference for monitoring therapeutic phenytoin levels.
authors.affiliation: crowder3@airmail.net
authors.forename: K M
authors.initials: KM
authors.lastname: Crowder
mesh_terms: D000465:Algorithms; D000927:Anticonvulsants / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy*; D019317:Evidence-Based Medicine; D006801:Humans; D009722:Nurse Practitioners; D010672:Phenytoin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012709:Serum Albumin / Q000032:analysis
chemical_list: D000927:Anticonvulsants; D012709:Serum Albumin; D010672:Phenytoin