Mechanisms of cross-talk between G-protein-coupled receptors.
There is increasing evidence to suggest that 'cross-talk' occurs between G-protein-coupled receptors and their intracellular second messenger pathways. Cross-talk between different pathways may occur at the level of receptors, G-proteins, effectors or second messengers and may serve to fine-tune cell signalling. There is a growing body of evidence to suggest that cellular compartmentalization may play a crucial role in regulating these cross-talk interactions. Understanding the mechanisms of cross-talk may therefore be the key to the design and application of future therapeutics and the development of drug specificity.
Cordeaux
Yolande
Y
Institute of Cell Signalling and School of Biomedical Sciences, Queens Medical Centre, Nottingham, UK. yolande.cordeaux@nottingham.ac.uk
Hill
Stephen J
SJ
D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D020239:Receptor Cross-Talk / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D015290:Second Messenger Systems / Q000502:physiology*
D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins