[Effect of manganese on the brain extrapyramidal development of rat offspring].
The effect of manganese (Mn) exposure on the behavior and extrapyramidal system of offspring were studied. Pregnant rats and their offspring in the experimental group were exposed to manganese from drinking water containing 2 g/L (low Mn-exposed group) or 10 g/L (high Mn-exposed group) of MnCl2 respectively. The latent period for running from the center field to any arm of Elevated Plus Arm Maze of both low and high Mn-exposed group was significantly reduced. But the latent period for reaching the platform above the water in Morris Water Maze of the Mn-exposed group was not different from that of control group. There was a significant increase in the areas, glial fibrillary acid protein(GFAP) immunoreactivity and the average proportional densities of GFAP-positive elements in nucleus caudate and accumbens in the high Mn-exposed group, and a significant reduction in the tyrosine hydroxylase immunoreactivity (TH) and average proportional densities of TH-positive elements in substantia nigra, ventral tegmentum area of midbrain and nucleus caudate in the high Mn-exposed group.
Zhang
D
D
Guangdong College of Pharmacy, Guangzhou 510224, China.
He
X
X
Zhang
W
W
Tan
J
J
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004781:Environmental Exposure; D005116:Extrapyramidal Tracts / Q000254:growth & development*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000009:adverse effects*; D018782:Maze Learning; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D005904:Glial Fibrillary Acidic Protein; D008345:Manganese; D014446:Tyrosine 3-Monooxygenase