[Effects of pyracantha fortuneana extract on blood coagulation].
OBJECTIVE
To study the effect of the Pyracantha fortuneana extract and its defferent polar fractions on blood coagulation.


RESULTS
The Pyracantha fortuneana extract could noticeably shorten the coagulation time of glass slide in mice (P < 0.05) after oral administration, and also shorten the recalcification time and prothrombin time in vitro (P < 0.01, P < 0.05), while in three polar fractions of the extract, the effects of the chloroform phase that could shorten the coagulation time of glass slide in mice(P < 0.01) after oral administration, and also shorten the recalcification time and prothrombin time in vitro (P < 0.01) are more noticeable than that of the acetic ether phase (P < 0.01, P < 0.05). The petroleum ether phase has no above-mentioned effect (P > 0.05).


CONCLUSIONS
The Pyracantha fortuneana extract can reduce the blood coagulation. Both the chloroform phase and the acetic ether phase of the extract have activity of blood coagulation, but the petroleum ether phase does not.
Mei
X
X
Life School of Science and Technology, Huazhong University of Science and Technology, Wuhan 430074.
Wan
G
G
Zhou
Z
Z
Chang
J
J
Wu
H
H
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D005638:Fruit / Q000737:chemistry*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D011517:Prothrombin Time; D027824:Rosaceae / Q000737:chemistry*; D014914:Whole Blood Coagulation Time
D010936:Plant Extracts; D002118:Calcium