title: Nuclease activity of [Cu(sulfathiazolato)(2)(benzimidazole)(2)]2MeOH. Synthesis, properties and crystal structure.
abstract: The [Cu(sulfathiazolato)(2)(benzimidazole)(2)]2MeOH complex has been synthesised and characterised. It crystallises in the monoclinic system, space group C1c1, with unit cell dimensions a=18.829(7) A, b=12.206(3) A, c=17.233(5) A, alpha=90.06(2) degrees, beta=97.28(3) degrees, gamma=90.21(3) degrees and Z=4. The geometry around the copper(II) ion is intermediate between tetrahedral and square planar. The complex produces cleavage of plasmid pUC18 in presence of reducing agents. The efficiency of cleavage reaction of the title compound with pUC18 and with different reducing agents follows the order ascorbate-H(2)O(2)>ascorbate>MPA>dithiothreitol>H(2)O(2).
authors.affiliation: Departamento de Química Inorgánica, Universidad de Valencia, Avda. Vicent Andrés Estellés, s/n, 46100, Burjassot, Spain.
authors.forename: M
authors.initials: M
authors.lastname: González-Alvarez
authors.forename: G
authors.initials: G
authors.lastname: Alzuet
authors.forename: J
authors.initials: J
authors.lastname: Borrás
authors.forename: B
authors.initials: B
authors.lastname: Macías
authors.forename: M
authors.initials: M
authors.lastname: del Olmo
authors.forename: M
authors.initials: M
authors.lastname: Liu-González
authors.forename: F
authors.initials: F
authors.lastname: Sanz
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003851:Deoxyribonucleases / Q000138:chemical synthesis* / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D000432:Methanol / Q000031:analogs & derivatives*; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D010957:Plasmids / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D000077589:Sulfathiazole; D013432:Sulfathiazoles / Q000737:chemistry*
chemical_list: C461021:(Cu(sulfathiazolato)(2)(benzimidazole)(2))2MeOH; D001562:Benzimidazoles; D009942:Organometallic Compounds; D013432:Sulfathiazoles; D003300:Copper; D003851:Deoxyribonucleases; D000432:Methanol; D000077589:Sulfathiazole