Cutaneous T-cell lymphoproliferative disorders: approach for the surgical pathologist: recent advances and clarification of confused issues.
Cutaneous T-cell lymphoproliferative disorders (CTCLs) remain a subject of confusion and controversy. In this review, the authors discuss diagnostic criteria and classification, including the role of immunohistochemistry and gene rearrangement studies. In addition, cutaneous T-cell pseudolymphomas, the current status of parapsoriasis and other premalignant syndromes, and the clinicopathological variants of mycosis fungoides are discussed. CD30-positive lymphoproliferative disorders and a number of rare variants of CTCL including granulamatous slack skin, subcutaneous (panniculitic) T-cell lymphoma, gamma-delta cutaneous lymphoma, NK/NK-like T-cell lymphoma, and primary cutaneous CD8-positive epidermotropic cytotoxic T-cell lymphoma are also considered.
Liu
Vincent
V
Department of Pathology, Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.
McKee
Phillip H
PH
D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D016410:Lymphoma, T-Cell, Cutaneous / Q000145:classification / Q000276:immunology / Q000473:pathology*; D008232:Lymphoproliferative Disorders / Q000276:immunology / Q000473:pathology; D009182:Mycosis Fungoides / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology; D019310:Pseudolymphoma / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology; D012878:Skin Neoplasms / Q000145:classification / Q000276:immunology / Q000473:pathology*