Study on quantitative structure-toxicity relationships of benzene derivatives acting by narcosis.
Hydrophobicity (logP) as well as quantiative structure-toxicity relationships (QSTRs) of some benzene derivatives acting by narcosis have been established based on narcotic mechanisms of action and toxicity data to the fathead minnow, Daphnia magna and Vibrio fischeri using information-theoretic topological index (Id). Excellent results are obtained in multiparametric regression upon introduction of dummy parameters (indicator variables). Consistent increase in R(2)(A) values indicated that inspite of collinarity between Id and one of the indicator variables (I(3-6)) the proposed models are statistically significant.
Khadikar
Padmakar V
PV
Research Division, Laxmi Fumigation and Pest Control Pvt. Ltd., 3, Khatipura, 452 007, Indore, India.
Mather
Keshav C
KC
Singh
Shalini
S
Phadnis
Anjani
A
Shrivastava
Anjali
A
Mandaloi
Manorama
M
D000818:Animals; D001555:Benzene Derivatives / Q000737:chemistry* / Q000633:toxicity*; D003530:Cyprinidae / Q000502:physiology; D057927:Hydrophobic and Hydrophilic Interactions; D018476:Hypokinesia / Q000139:chemically induced; D020128:Inhibitory Concentration 50; D016015:Logistic Models; D021281:Quantitative Structure-Activity Relationship; D018675:Toxicity Tests / Q000379:methods*; D014733:Vibrio / Q000187:drug effects
D001555:Benzene Derivatives