title: Studies on sister chromatid exchanges in peripheral lymphocytes of spray painters.
abstract: In a comparative study of sister chromatid exchanges (SCEs) in cultured lymphocytes, we evaluated the genotoxic risk in 104 male spray painters employed in repair workshops in Chennai City, India, and 50 matched healthy, unexposed controls. We found a higher frequency of SCEs among painters (3.74 +/- 0.11, mean +/- SE) than among controls (2.15 +/- 0.08), and among smoking painters (4.03 +/- 0.21) than among nonsmoking painters (3.55 +/- 0.13), with no significant difference in controls (smokers: 2.1 +/- 0.2; nonsmokers: 2.2 +/- 0.1). Alcoholism did not contribute to an increased SCE frequency. Stepwise multiple linear regression analysis on painters showed that duration of service, smoking, and alcoholism significantly affected SCE scores and explained the 14% variation observed.
authors.affiliation: Department of Genetics, Dr. ALMPGIBMS, University of Madras, Taramani Chennai, India.
authors.forename: Palanivel
authors.initials: P
authors.lastname: Gajalakshmi
authors.forename: Protima
authors.initials: P
authors.lastname: Mallick
authors.forename: Perumal
authors.initials: P
authors.lastname: Venkatesan
authors.forename: Sathyaveedu Thiagarjan
authors.initials: ST
authors.lastname: Santhiya
authors.forename: Arabandi
authors.initials: A
authors.lastname: Ramesh
mesh_terms: D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000150:complications; D006801:Humans; D019570:Inhalation Exposure; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D010150:Paint; D012044:Regression Analysis; D012854:Sister Chromatid Exchange; D012907:Smoking / Q000009:adverse effects; D013997:Time Factors