title: ICAM-1 in maternal serum and amniotic fluid as an early marker of preeclampsia and IUGR.
abstract: OBJECTIVE
  To determine if plasma and amniotic fluid levels of intercellular adhesion molecule-1 (ICAM-1) at 16 weeks' gestation could be predictive of preeclampsia or intrauterine growth retardation (IUGR).
  
  
  METHODS
  A retrospective analysis was undertaken in 44 serum samples stored for Down's syndrome screening at 16 weeks' gestation and 44 amniotic fluid samples obtained by midtrimester amniocentesis.
  
  
  RESULTS
  No significant difference was found between women who subsequently developed preeclampsia or IUGR and the control group.
  
  
  CONCLUSIONS
  This study failed to demonstrate that ICAM-1 may be an early serum marker of preeclampsia or an amniotic fluid marker of IUGR.
authors.affiliation: Departments of Gynecology and Internal Medicine, University of Messina, Messina, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Baviera
authors.forename: Rosario
authors.initials: R
authors.lastname: D'Anna
authors.forename: Francesco
authors.initials: F
authors.lastname: Corrado
authors.forename: Antonella
authors.initials: A
authors.lastname: Ruello
authors.forename: Michele
authors.initials: M
authors.lastname: Buemi
authors.forename: Valerio Maria
authors.initials: VM
authors.lastname: Jasonni
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry*; D015415:Biomarkers / Q000032:analysis*; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1