title: Evidence base of clinical diagnosis:    Rational, cost effective use of investigations in clinical practice.
authors.affiliation: Department of General Practice and Transmural Care Unit, University Hospital, 6200 MD Maastricht, Netherlands. ron.winkens@hag.unimaas.nl
authors.forename: Ron
authors.initials: R
authors.lastname: Winkens
authors.forename: Geert-Jan
authors.initials: GJ
authors.lastname: Dinant
mesh_terms: D003362:Cost-Benefit Analysis; D019937:Diagnostic Techniques and Procedures / Q000191:economics*; D004059:Diffusion of Innovation; D019317:Evidence-Based Medicine; D006801:Humans; D017410:Practice Guidelines as Topic; D011364:Professional Practice / Q000191:economics