title: Bud-site selection and cell polarity in budding yeast.
abstract: Polarized growth involves a hierarchy of events such as selection of the growth site, polarization of the cytoskeleton to the selected growth site, and transport of secretory vesicles containing components required for growth. The budding yeast Saccharomyces cerevisiae is an excellent model system for the study of polarized cell growth. A large number of proteins have been found to be involved in these processes, although their mechanisms of action are not yet well-understood. Recent discoveries have helped elucidate many of the processes involved in cell polarity and bud-site selection in yeast and have modified the traditional view of cellular structures involved in these processes. This review focuses on recent advances on the roles of cortical tags, GTPases and the cytoskeleton in the generation and maintenance of cell polarity in yeast.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520-8103, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: Casamayor
authors.forename: Michael
authors.initials: M
authors.lastname: Snyder
mesh_terms: D000199:Actins / Q000235:genetics / Q000502:physiology; D016764:Cell Polarity; D003599:Cytoskeleton / Q000737:chemistry; D004718:Saccharomycetales / Q000737:chemistry / Q000254:growth & development*; D020846:cdc42 GTP-Binding Protein, Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology
chemical_list: D000199:Actins; D020846:cdc42 GTP-Binding Protein, Saccharomyces cerevisiae