Role of chronic Helicobacter pylori infection in hyperdynamic circulation of cirrhotic patients.
OBJECTIVE
Hyperdynamic circulation observed in portal hypertension is characterized by generalized vasodilatation, increased cardiac index, and increased systemic and regional blood flows, and mediated at least partly by increased nitric oxide activities. Recent studies have demonstrated that Helicobacter pylori (H. pylori) infection can stimulate nitric oxide synthase expression and activities. This study investigated if chronic H. pylori infection might be involved in the development of hyperdynamic circulation in cirrhotic patients.


METHODS
Fifty-eight patients with cirrhosis and thirty-six healthy subjects entered this study. The serologic evidence of H. pylori infection was determined with ELISA in both groups. In addition, in cirrhotic patients hemodynamic studies were performed by Swan-Ganz catheterization and thermodilution technique.


RESULTS
No significant differences in age (65.5 +/- 0.8 vs. 63.7 +/- 1.1 years), sex (male/female: 43/15 vs. 29/7) and seroprevalence of H. pylori (74.1% vs. 80.6%) were observed between cirrhotic patients and healthy subjects (P > 0.05). The seropositive rate of H. pylori in patients with cirrhosis was not associated with severity of cirrhosis and size of esophageal varices (P > 0.05). There were no significant differences in systemic vascular resistance and hepatic venous pressure gradient between cirrhotic patients with and those without chronic H. pylori infection (P > 0.05).


CONCLUSIONS
The seroprevalence of H. pylori in cirrhotic patients is similar to that of healthy controls, and not related to the severity of cirrhosis and degree of portal hypertension. Chronic H. pylori infection does not play a major role in the hyperdynamic circulation observed in cirrhotic patients.
Chen
Chien-Ting
CT
Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine.
Wang
Teh-Fang
TF
Chan
Che-Chang
CC
Lee
Fa-Yauh
FY
Chang
Full-Young
FY
Lin
Han-Chieh
HC
Hou
Ming-Chih
MC
Lu
Rei-Hwa
RH
Chu
Chi-Jen
CJ
Wang
Sun-Sang
SS
Lee
Shou-Dong
SD
D000368:Aged; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D016480:Helicobacter pylori; D006439:Hemodynamics; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology; D008102:Liver Circulation / Q000502:physiology*; D008103:Liver Cirrhosis / Q000382:microbiology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies