title: Evaluation of Bioglass/dextran composite as a bone graft substitute.
abstract: Allogenic and alloplastic bone graft substitutes serve either as bioinert or bioactive osteoconductors. Bioglass is a bioactive osteoconductor and also shows osteoproductive effects due to its high level of bioactivity. However, the material lacks some cohesiveness when used in augmenting certain bony surfaces, i.e. large or pleomorphic defects. The addition of medium molecular weight dextran modifies the particulate to a putty consistency and improves the handling characteristics. The objective of this study is to evaluate the influence of dextran upon the bioactive properties of Bioglass. Standardized bony defects in the lateral femoral condyles in adult New Zealand white rabbits were filled with one of five material groups: (1) autogenous bone; (2) Bioglass particulate; (3) Bioglass particulate mixed with dextran to a putty-like consistency; (4) a mixture of Bioglass and autogenous bone; (5) a mixture of Bioglass putty with autogenous bone. Postoperative healing was observed after periods of 2 days, 1, 2, 3, 6 and 12 weeks. Results showed no evidence of toxicity in the dextran-containing materials, and defects in all test groups showed 100% bony ingrowth within 6 weeks. The addition of medium molecular weight dextran did not appear to alter the bioactive properties of Bioglass and had no adverse influence upon the ingrowth of bone into the defect sites.
authors.affiliation: Department of Oral & Maxillofacial Surgery, Guy's Hospital, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Chan
authors.forename: I
authors.initials: I
authors.lastname: Thompson
authors.forename: P
authors.initials: P
authors.lastname: Robinson
authors.forename: J
authors.initials: J
authors.lastname: Wilson
authors.forename: L
authors.initials: L
authors.lastname: Hench
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes; D016025:Bone Transplantation; D002516:Ceramics / Q000494:pharmacology*; D003911:Dextrans / Q000633:toxicity*; D004338:Drug Combinations; D005269:Femur / Q000601:surgery; D008297:Male; D011817:Rabbits
chemical_list: C022107:Bioglass; D018786:Bone Substitutes; D003911:Dextrans; D004338:Drug Combinations