title: Miniature surface-plasmon resonance immunosensors--rapid and repetitive procedure.
abstract: Miniaturized immunosensors based on surface-plasmon resonance (SPR) have been developed by using the sensor recently developed by Texas Instruments. By using this sensor for human immunoglobulin G (IgG) rapid and repetitive measurements could be performed by alternate injection of sample and glycine-HCl buffer. A sensor for human serum albumin (HSA) could also be developed similarly. One difficulty in immunosensor development is dissociation of the strongly bound antigen-antibody complex. A "regenerable" immunosensor has also been developed for this reason.
authors.affiliation: Department of Electric and Electronic Engineering, Toyama University, Japan.
authors.forename: Masayasu
authors.initials: M
authors.lastname: Suzuki
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Ozawa
authors.forename: Wakako
authors.initials: W
authors.lastname: Sugimoto
authors.forename: Shuji
authors.initials: S
authors.lastname: Aso
mesh_terms: D000937:Antigen-Antibody Reactions; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D002138:Calibration; D004867:Equipment Design; D017743:Equipment Reuse; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008904:Miniaturization; D012709:Serum Albumin / Q000032:analysis; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods / Q000592:standards; D013997:Time Factors
chemical_list: D007074:Immunoglobulin G; D007136:Immunoglobulins; D012709:Serum Albumin