title: A 25-year-old man with a large hepatic tumor and multiple nodular lesions.
abstract: A 25-year-old man without a prior history of liver disease presented with an 18-cm tumor of the right hepatic lobe, which was associated with multiple nodular lesions in the remaining parenchyma. The histologic and immunohistochemical features of the neoplasm were those of a poorly differentiated leiomyosarcoma with epithelioid features. The nodular lesions measured up to 4 cm in greatest dimension and had gross and microscopic features of focal nodular hyperplasia. This case suggests that multiple focal nodular hyperplasia may occasionally represent a parenchymal reaction to abnormal blood supply developing within the liver as a consequence of an enlarging malignant tumor.
authors.affiliation: Department of Pathology, Aristotle University Medical School, 540 06 Thessaloniki, Greece.
authors.forename: Fotis
authors.initials: F
authors.lastname: Iordanidis
authors.forename: Prodromos
authors.initials: P
authors.lastname: Hytiroglou
authors.forename: Antonios
authors.initials: A
authors.lastname: Drevelegas
authors.forename: Fotis
authors.initials: F
authors.lastname: Kodonas
authors.forename: Ioannis
authors.initials: I
authors.lastname: Ioannidis
authors.forename: Helen
authors.initials: H
authors.lastname: Nenopoulou
authors.forename: Constantine S
authors.initials: CS
authors.lastname: Papadimitriou
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D020518:Focal Nodular Hyperplasia / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male