[Piperacillin-tazobactam in the treatment of severe nosocomial infections].
Epidemiology and clinical manifestations of nosocomial infections have been progressively evolving through last three decades. New pathogens, often associated to multiple antibiotic-resistances, are now among the leading etiologies in a patient population mainly represented by individuals debilitated by serious underlying diseases, immunosuppressive treatments and multiple diagnostic and therapeutic invasive procedures. Under these circumstances, when an infectious complication develops, prompt initiation of empiric antibiotic therapy, based on general and/or local epidemiology of nosocomial infections, may be crucial for survival of more critically ill patients. Based on recent data, the antibiotics of choice for treatment of nosocomial infections should have not only a bactericidal activity and a broad antibacterial spectrum, but also poor propensity to induce antibiotic-resistance and a satisfactory pharmacoeconomy profile. After a detailed description of the above mentioned context, the pre-eminent role of piperacillin-tazobactam in the treatment of nosocomial infections is reviewed and discussed.
Venditti
Mario
M
Servizio Aggregato di Consulenze Internistico-Infettivologiche, Cattedra di Clinica Medica III, Dipartimento di Medicina Clinica, Università La Sapienza, Roma.
Cassone
Marco
M
Falcone
Marco
M
Pavoni
Gianluca
G
Pistella
Eleonora
E
Paris
Alberto
A
D001419:Bacteria / Q000187:drug effects; D002986:Clinical Trials as Topic; D003365:Costs and Cost Analysis; D003428:Cross Infection / Q000188:drug therapy* / Q000191:economics / Q000382:microbiology; D004338:Drug Combinations; D024881:Drug Resistance, Bacterial; D004791:Enzyme Inhibitors / Q000008:administration & dosage* / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009503:Neutropenia / Q000150:complications; D010397:Penicillanic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use; D010406:Penicillins / Q000008:administration & dosage* / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use; D010878:Piperacillin / Q000008:administration & dosage* / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use; D011014:Pneumonia / Q000188:drug therapy; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors
D004338:Drug Combinations; D004791:Enzyme Inhibitors; D010406:Penicillins; D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin
Piperacillina-tazobactam nel trattamento delle infezioni gravi nosocomiali.