title: [Dehydroepiandrosterone (DHEA)--youth hormone?].
abstract: Dehydroepiandrosterone (DHEA) and its sulphated metabolite (DHEA-S) are endogenous steroid hormones, synthesized by the adrenal cortex, gonads and CNS. The secretion profile changes with age and depends on the sex. Human DHEA and DHEA-S levels decline linearly and systematically with age and suggest the potential importance of that parameter as a biomarker of ageing. The counteraction of DHEA against atherosclerotic disease, cancer growth, diabetes mellitus, insulin resistance, obesity and the influence on immunological functions are observed in researches. DHEA influences the condition of mind, cognition functions, memory and well-being. DHEA hormonal replacement therapy is expected to lengthen human life by the stoppage of physiological degeneration changes and prevention of age-related clinical disorders.
authors.affiliation: Katedry i Kliniki Endokrynologii i Diabetologii Akademii Medycznej we Wrocławiu.
authors.forename: Z
authors.initials: Z
authors.lastname: Zdrojewicz
authors.forename: S
authors.initials: S
authors.lastname: Kesik
mesh_terms: D000375:Aging / Q000378:metabolism*; D001161:Arteriosclerosis / Q000517:prevention & control; D003071:Cognition / Q000187:drug effects; D003687:Dehydroepiandrosterone / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D019314:Dehydroepiandrosterone Sulfate / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000517:prevention & control; D006801:Humans; D007333:Insulin Resistance; D008568:Memory / Q000187:drug effects; D009369:Neoplasms / Q000517:prevention & control; D009765:Obesity / Q000517:prevention & control; D011788:Quality of Life
chemical_list: D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate
vernacular_title: Dehydroepiandrosteron (DHEA)--hormon młodości?