Angiotensin converting enzyme gene insertion/deletion polymorphism: case-control association studies in schizophrenia, major affective disorder, and tardive dyskinesia and a family-based association study in schizophrenia.
Angiotensin converting enzyme (ACE) is a candidate gene for psychiatric disorders. We examined the frequency of a functional insertion/deletion (I/D) polymorphism in the 16th intron of the ACE gene (located on chromosome 17q23) in groups of patients with schizophrenia (n = 104 and 113), major depression (n = 55), and bipolar disorder (n = 87) compared to healthy control subjects (n = 87). There was no evidence for allelic or genotypic association of the polymorphism with any of the disorders or with tardive dyskinesia (TD) in patients with schizophrenia. In a sample of nuclear families (n = 61) made up of one or more patients with schizophrenia recruited with their parents, there was no evidence for biased transmission of ACE I/D alleles. Particularly in the case of schizophrenia, these findings do not support an association of the ACE I/D polymorphism with the phenotypes examined.
Segman
Ronnen H
RH
Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. sronen@md2.huji.ac.il
Shapira
Yami
Y
Modai
Ilan
I
Hamdan
Adnan
A
Zislin
Joseph
J
Heresco-Levy
Uriel
U
Kanyas
Kyra
K
Hirschmann
Shmuel
S
Karni
Osnat
O
Finkel
Boris
B
Schlafman
Michael
M
Lerner
Arturo
A
Shapira
Baruch
B
Macciardi
Fabio
F
Lerer
Bernard
B
D000483:Alleles; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D004409:Dyskinesia, Drug-Induced / Q000201:enzymology / Q000235:genetics*; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000201:enzymology / Q000235:genetics*; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics*; D017384:Sequence Deletion
D004247:DNA; D007703:Peptidyl-Dipeptidase A