Preclinical evaluation of a new hollow fiber silicone membrane oxygenator for pediatric cardiopulmonary bypass: ex-vivo study.
Based on the results of many experimental models, a hollow fiber silicone membrane oxygenator applicable for long-term extracorporeal membrane oxygenation (ECMO) was developed. For further high performance and antithrombogenicity, this preclinical model was modified, and a new improved oxygenator was successfully developed. In addition to ECMO application, the superior biocompatibility of silicone must be advantageous for pediatric cardiopulmonary bypass (CPB). An ex vivo short-term durability test for pediatric CPB was performed using a healthy miniature calf for six hours. Venous blood was drained from the left jugular vein of a calf, passed through the oxygenator and infused into the left carotid artery using a Gyro C1E3 centrifugal pump. For six hours, the O2 and CO2 gas transfer rates were maintained around 90 and 80 ml/min at a blood flow rate of 2 L/min and V/Q=3, respectively. The plasma free hemoglobin was maintained around 5 mg/dl. These data suggest that this newly improved oxygenator has superior efficiency, less blood trauma, and may be suitable for not only long-term ECMO but also pediatric CPB usage.
Kawahito
Shinji
S
Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, USA.
Haraguchi
Shuji
S
Maeda
Tomohiro
T
Motomura
Tadashi
T
Takano
Tamaki
T
Nonaka
Kenji
K
Linneweber
Joerg
J
Ichikawa
Seiji
S
Kawamura
Masaki
M
Ishitoya
Hiroshi
H
Glueck
Julie
J
Sato
Koshiro
K
Nosé
Yukihiko
Y
D000818:Animals; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D002417:Cattle; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D010107:Oxygenators, Membrane; D010372:Pediatrics / Q000295:instrumentation; D012828:Silicones
D012828:Silicones