[Effects of nebivolol on serum levels of NO2 and NO3 oxides in patients with type 2 diabetes mellitus].
In patients with type 2 diabetes mellitus, we used nevibolol, a lipophilic high-selective beta 1-blocker. It has been found out that the drug, while augmenting the synthesis of nitrogen oxide, improves antioxidant properties. Therefore, it can be recommended for use in patients with type 2 diabetes mellitus concurrent with arterial hypertension to achieve normalization of arterial pressure and accomplish a correction of endothelial dysfunction.
Mohyl'nyts'ka
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Man'kovskyĭ
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D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D001578:Benzopyrans / Q000494:pharmacology / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D004983:Ethanolamines / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000068577:Nebivolol; D009569:Nitric Oxide / Q000097:blood; D019001:Nitric Oxide Synthase / Q000378:metabolism; D009585:Nitrogen Dioxide / Q000097:blood*; D009589:Nitrogen Oxides / Q000097:blood*
D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D004983:Ethanolamines; D009589:Nitrogen Oxides; D000068577:Nebivolol; C031701:nitrogen trioxide; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D009585:Nitrogen Dioxide
Vplyv nebivololu na riven' metabolitiv oksydu azotu NO2 ta NO3 v syrovattsi krovi khvorykh na tsukrovyĭ diabet typu 2.