[Synthesis and biological activity of 2,3-benzopyrone analogs].
Several 2, 3-benzopyrone analogs were synthesized for evaluating their K(+)-channel and anticancer activities. The Friedel-Crafts reaction was taken place with some replacement phenyl acetic acid or its methyl ester and vanillin as reactants in the condition of Ac2O/ZnCl2. All products were confirmed by means of MS and 1H, 13CNMR spectra. Compounds 2 and 3 showed obvious activities on the K(+)-channel and anticancer screening, while the activity of compound 5 was weak. Compound 4 was not yet tested. The primary result indicate that the potential activity of such compounds deserves further study.
Ji
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X
Department of Clinical Pharmacy, General Hospital of Air Force, PLA, Beijing 100036.
Liang
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D000970:Antineoplastic Agents / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D015221:Potassium Channels / Q000187:drug effects*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D001578:Benzopyrans; D015221:Potassium Channels