[Effects of medium-weight molecules isolated from plasma of healthy and burnt animals on the cellular composition of cultured bone marrow erythroblastic islets].
The so-called median-weight molecular fractions (M, B = 0.5-1.5 kDa) exerting a marked hemopoietic effect in the cultured bone marrow erythroblastic islets were isolated from the plasma deproteinates of healthy dogs and animals with acute inflammation (thermal skin burn) by Sephadex G-15 gel chromatography. Acute inflammation is attended by the occurrence of blood medium-weight molecular components that suppress erythropiesis and by the concurrent high rate of granulocytopoiesis in the cultured bone marrow erythroblastic islets. Medium-weight molecular fractions from the blood of healthy dogs substantially were found to suppress erythropoiesis and to stimulate granulocytopoiesis in the cultured erythroblastic islets.
Volchegorskiĭ
I A
IA
Tishevskaia
N V
NV
Kuznetsov
D A
DA
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism*; D002056:Burns / Q000097:blood*; D002458:Cell Fractionation / Q000295:instrumentation; D004285:Dogs; D004900:Erythroblasts / Q000378:metabolism*; D004920:Erythropoiesis / Q000502:physiology*; D006824:Hybridization, Genetic / Q000502:physiology; D008970:Molecular Weight
Vliianie "srednikh molekul", vydelennykh iz plazmy krovi intaktnykh i obozhzhennykh zhivotnykh, na kletochnyĭ sostav kul'tur éritroblasticheskikh ostrovkov kostnogo mozga.