title: YM-181741, a novel benz[a]anthraquinone antibiotic with anti-Helicobacter pylori activity from Streptomyces sp.
abstract: A novel benz[a]anthraquinone, YM-181741, was isolated from the culture broth of actinomycete strain Q57219. The strain was identified as Streptomyces sp. by morphological and chemotaxonomic characterization. YM-181741 was purified from the culture supernatant by serial column chromatography. The structure of YM-181741 was determined by spectroscopic analysis including one- and two-dimensional NMR experiments. YM-181741 showed selective anti-Helicobacterpylori activity with a MIC value of 0.2 microg/ml.
authors.affiliation: Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., Ibaraki, Japan. taniguti@yamanouchi.co.jp
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Taniguchi
authors.forename: Koji
authors.initials: K
authors.lastname: Nagai
authors.forename: Masato
authors.initials: M
authors.lastname: Watanabe
authors.forename: Nami
authors.initials: N
authors.lastname: Nimura
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tanaka
mesh_terms: D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D016480:Helicobacter pylori / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013302:Streptomyces
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; C451493:YM 181741