Molecular mechanisms of hepatitis B virus-associated liver cancer.
Hepatitis B infection is associated with an increased risk of hepatocellular carcinoma development. Hepatitis B proteins, such as the hepatitis B x protein, the large hepatitis B surface protein, or truncated middle hepatitis B surface proteins, regulate transcription of many candidate genes for liver carcinogenesis by trans-mechanisms. They also alter mechanisms of apoptosis and interfere with nucleotide excision repair of damaged DNA. Together with an influence on cellular signaling, these mechanisms may favor the cell's clonal expansion.
Rabe
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Department of Medicine I, University of Bonn, Germany.
Cheng
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Caselmann
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D000956:Antigens, Viral; D017209:Apoptosis; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000821:virology*; D002471:Cell Transformation, Neoplastic; D004249:DNA Damage; D004260:DNA Repair; D006509:Hepatitis B / Q000150:complications*; D006515:Hepatitis B virus / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000821:virology*; D009362:Neoplasm Metastasis; D012307:Risk Factors; D015398:Signal Transduction; D014764:Viral Proteins
D000956:Antigens, Viral; D014764:Viral Proteins