Targeting the "species gene ensemble".
The members of a given species display a normal distribution of gene expression which is here termed the species gene ensemble. This more specific designation of the 'genetic background' leads to a consideration of why gene targeting outcomes are regulated by the species gene ensemble. One consequence is the utility of the heterozygous knockout which buffers the drastic compensatory reactions of the homozygous knockout thereby revealing subtle but yet consistent alterations in hippocampally-dependent behaviors.
Routtenberg
Aryeh
A
Cresap Neuroscience Laboratory, Department of Psychology, Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208, USA. aryeh@northwestern.edu
D000818:Animals; D019922:GAP-43 Protein / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D018390:Gene Targeting; D006579:Heterozygote; D006624:Hippocampus / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D019655:Quantitative Trait, Heritable
D019922:GAP-43 Protein