title: Proliferating cell nuclear antigen (PCNA) immunoreactivity and development of the pineal complex and habenula of the sea lamprey.
abstract: The development of the pineal complex and the habenula of the sea lamprey was studied with proliferating cell nuclear antigen (PCNA) immunocytochemistry. The pineal organ and the habenula primordia appeared in late embryos, and neuron differentiation began in prolarvae, as indicated by the presence of PCNA-negative cells. The parapineal primordium could not be distinguished until early prolarval stages, and cell differentiation was delayed to the larval period. Although the number of cycling (PCNA-immunoreactive) cells gradually decreased during the larval period in the three organs studied, their patterns of differentiation were different. We conclude that the unusual developmental pattern observed is related with the complex life cycle of lampreys.
authors.affiliation: Department of Fundamental Biology, Faculty of Biology, University of Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Begoña
authors.initials: B
authors.lastname: Villar-Cheda
authors.forename: Emma
authors.initials: E
authors.lastname: Pérez-Costas
authors.forename: Miguel
authors.initials: M
authors.lastname: Meléndez-Ferro
authors.forename: Xesús Manoel
authors.initials: XM
authors.lastname: Abalo
authors.forename: Rolando
authors.initials: R
authors.lastname: Rodríguez-Muñoz
authors.forename: Ramón
authors.initials: R
authors.lastname: Anadón
authors.forename: María Celina
authors.initials: MC
authors.lastname: Rodicio
mesh_terms: D000818:Animals; D004625:Embryo, Nonmammalian / Q000378:metabolism; D019262:Habenula / Q000196:embryology* / Q000254:growth & development*; D007150:Immunohistochemistry; D007798:Lampreys / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism*; D007814:Larva / Q000378:metabolism; D010870:Pineal Gland / Q000196:embryology* / Q000254:growth & development*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*
chemical_list: D018809:Proliferating Cell Nuclear Antigen