title: [Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration].
abstract: OBJECTIVE
  To evaluate the proper clinical dosage of indocyanine green(ICG) in angiography for detecting choroidal neovascularization(CNV) of exudative age-related macular degeneration(AMD).
  
  
  METHODS
  Indocyanine green angiography (IA) was performed using a randomized crossover method with two different doses on two occasions. Ease of detection, side effects and clinical serum data were also evaluated.
  
  
  RESULTS
  Among the 39 eyes, detection of CNV using 12.5 mg and 25 mg was most effective in 21 and 31 eyes respectively, showing a statistically significant difference. Slight vomiting was observed temporarily in one patient who had taken 25 mg.
  
  
  CONCLUSIONS
  A dose of 25 mg is appropriate for detection of CNV of exudative AMD and this dosage raises no safety concerns.
authors.affiliation: Department of Ophthalmology, Surugadai Hospital of Nihon University, 1-8-13 Surugadai, Kanda, Chiyoda-ku, Tokyo 101-8309, Japan.
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Yuzawa
authors.forename: Shin
authors.initials: S
authors.lastname: Yoneya
authors.forename: Masanobu
authors.initials: M
authors.lastname: Uyama
authors.forename: Kanji
authors.initials: K
authors.lastname: Takahashi
authors.forename: Muneyasu
authors.initials: M
authors.lastname: Takeda
authors.forename: Fumio
authors.initials: F
authors.lastname: Shiraga
authors.forename: Tokuhiko
authors.initials: T
authors.lastname: Miki
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Shiraki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hayashi
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ogura
authors.forename: Sadao
authors.initials: S
authors.lastname: Komemushi
authors.forename: Mizuo
authors.initials: M
authors.lastname: Matsui
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000175:diagnosis*; D018592:Cross-Over Studies; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage*; D008268:Macular Degeneration / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D007208:Indocyanine Green