title: Possible role of corticosteroids in nervous system plasticity: improvement in amblyopia after optic neuritis in the fellow eye treated with steroids.
abstract: OBJECTIVE
  Amblyopia consists of reduced visual function in the absence of organic disease, caused by deficient visual stimulation, most commonly due to squint or refractive error. Amblyopia is thought to be reversible up until the age of approximately 8 years (critical period) and is usually treated with occlusion of the fellow eye. There is recent evidence for visual system plasticity extending beyond the critical period, supported by reports of improvement in visual acuity in the amblyopic eye after loss of vision in the contralateral eye. This suggests that the adult visual system exhibits sufficient plasticity to allow such improvement. We describe here improvement in visual acuity in three amblyopic patients after they received high-dose intravenous glucocorticoids for optic neuritis in the contralateral eye.
  
  
  METHODS
  Clinical and neurological evaluation added.
  
  
  RESULTS
  In all cases, the improvement was sustained, even after the recovery from the optic neuritis.
  
  
  CONCLUSIONS
  Because steroids affect neural plasticity, we hypothesize that they facilitate and enhance visual improvement in amblyopia, a quality that may be tested in future controlled trials.
authors.affiliation: Division of Clinical Neurology, University Hospital, Queen's Medical Centre, Nottingham, UK. cris.constantinescu@nottingham.ac.uk
authors.forename: C S
authors.initials: CS
authors.lastname: Constantinescu
authors.forename: I
authors.initials: I
authors.lastname: Gottlob
mesh_terms: D000328:Adult; D000550:Amblyopia / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects*; D009902:Optic Neuritis / Q000150:complications / Q000188:drug therapy*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D005938:Glucocorticoids