title: Primary hyperparathyroidism is associated with an impaired secretion of growth hormone but not of the other anterior pituitary hormones.
abstract: We have recently reported that GH secretion is impaired in primary hyperparathyroidism (PHP). No systematic assessment of the whole anterior pituitary function in PHP is available. In this study, anterior pituitary function was evaluated in basal and stimulated conditions in a series of 12 consecutive women with PHP. Serum GH secretion was decreased in 9 of 12 PHP patients (75%) confirming our previous results in different series of PHP patients. Instead, at variance, secretion of all the other anterior pituitary hormones was normal. Thus, PHP is associated with an impaired secretion of GH, but not of the other anterior pituitary hormones. The reason why only GH secretion is affected in PHP is unknown.
authors.affiliation: Department of Endocrinology, University of Pisa, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Cecconi
authors.forename: M
authors.initials: M
authors.lastname: Gasperi
authors.forename: L
authors.initials: L
authors.lastname: Grasso
authors.forename: M
authors.initials: M
authors.lastname: Genovesi
authors.forename: G
authors.initials: G
authors.lastname: Aimaretti
authors.forename: F
authors.initials: F
authors.lastname: Broglio
authors.forename: L
authors.initials: L
authors.lastname: Bartalena
authors.forename: C
authors.initials: C
authors.lastname: Marcocci
authors.forename: E
authors.initials: E
authors.lastname: Martino
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000368:Aged; D001120:Arginine; D002118:Calcium / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D013007:Growth Hormone-Releasing Hormone; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D006961:Hyperparathyroidism / Q000503:physiopathology*; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D010908:Pituitary Hormones, Anterior / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000097:blood
chemical_list: D010908:Pituitary Hormones, Anterior; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013007:Growth Hormone-Releasing Hormone; D001120:Arginine; D002118:Calcium