Novel matrix metallo-proteinase (MMP-2) phosphonoboronate inhibitors.
A series of novel phosphonoboronates consisting of PC(1)B, PC(n)B, PC(X)C(n)B, and PCC=CB derivatives were evaluated as MMP-2 inhibitors. Structure-activity relationships (SARs) data for the compounds were discovered and are discussed.
Pergament
Inna
I
Department of Medicinal Chemistry and Natural Products, Hebrew University in Jerusalem, POB 12065, 91120, Jerusalem, Israel.
Reich
Reuven
R
Srebnik
Morris
M
D001896:Boron Compounds / Q000737:chemistry* / Q000494:pharmacology*; D002633:Chemotaxis / Q000187:drug effects; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D001896:Boron Compounds; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors