title: Non-linear model for the kinetics of 10B in blood after BPA-fructose complex infusion.
abstract: A numerical model with a memory effect was created to describe the kinetics of 10B in blood after a single 4-dihydroxyborylphenylalanine-fructose complex (BPA-F) infusion in boron neutron capture therapy (BNCT). The model formulation was based on the averaged data from 10 glioma patients from the Brookhaven National Laboratory (BNL) BNCT-trials. These patients received a 2 h i.v. infusion of a BPA-fructose complex that delivered 290 mg BPA/kg body weight. The model was validated by fitting the original BNL patient data and new patient data from the Finnish BNCT-trials. The new 3-parameter non-linear model provided mean absolute differences between the measured and estimated 10B concentrations in blood that were less than 3.9% when used to simulate actual patient irradiations that comprised two irradiation fields separated by a break to reposition the patient. The flexibility of the model was successfully tested with two different infusion protocols. The patient data were modelled with a two-compartment model and a bi-exponential fit for comparison. The 3-parameter model is better than previously described models in predicting the time course of blood 10B concentration after cessation of intravenous infusion of BPA-fructose.
authors.affiliation: Department of Physical Sciences, University of Helsinki, Finland.
authors.forename: Päivi
authors.initials: P
authors.lastname: Ryynänen
authors.forename: Aki
authors.initials: A
authors.lastname: Kangasmäki
authors.forename: Pekka
authors.initials: P
authors.lastname: Hiismäki
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Coderre
authors.forename: Aidnag Z
authors.initials: AZ
authors.lastname: Diaz
authors.forename: Merja
authors.initials: M
authors.lastname: Kallio
authors.forename: Juha
authors.initials: J
authors.lastname: Laakso
authors.forename: Martti
authors.initials: M
authors.lastname: Kulvik
authors.forename: Sauli
authors.initials: S
authors.lastname: Savolainen
mesh_terms: D001895:Boron / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D001896:Boron Compounds / Q000737:chemistry; D005632:Fructose / Q000737:chemistry; D006801:Humans; D007554:Isotopes / Q000627:therapeutic use; D007700:Kinetics; D015233:Models, Statistical; D008962:Models, Theoretical; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry; D011874:Radiometry / Q000379:methods*; D013997:Time Factors; D014055:Tomography, Emission-Computed
chemical_list: C436045:4-dihydroxyborylphenylalanine; D001896:Boron Compounds; D007554:Isotopes; D005632:Fructose; D010649:Phenylalanine; D001895:Boron