[A case of allopurinol-induced muscular damage in a chronic renal failure patient].
A 73-year-old woman with chronic renal failure developed generalized muscular weakness and pain 6 days after the start of allopurinol treatment(200 mg/day). Routine laboratory tests revealed elevated levels of serum creatine kinase, and the patient was clinically diagnosed as rhabdomyolysis, due probably to severe myositis. A high level of serum oxipurinol, the chief active metabolite of allopurinol, was also revealed. The muscular weakness was relieved in seven weeks with intermittent hemodiafiltration.
Terawaki
Hiroyuki
H
Department of Nephrology, Department of Orthopedics, Sakura National Hospital, Chiba, Japan.
Suzuki
Takahide
T
Yoshimura
Kazunobu
K
Hasegawa
Toshio
T
Takase
Hiromi
H
Nemoto
Tetsuharu
T
Hosoya
Tatsuo
T
D000368:Aged; D000493:Allopurinol / Q000009:adverse effects*; D005260:Female; D017583:Hemodiafiltration; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D009220:Myositis / Q000139:chemically induced* / Q000628:therapy; D010117:Oxypurinol / Q000097:blood; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000628:therapy
D000493:Allopurinol; D010117:Oxypurinol