Effects of non-steroidal anti-inflammatory drugs on hypertension control using angiotensin converting enzyme inhibitors and thiazide diuretics.
OBJECTIVE
To determine the impact of three non-steroidal anti-inflammatory drugs on the efficacy of two anti-hypertensive drugs.


METHODS
Fifteen women with arthritis and hypertension who were receiving lisinopril and HCT, and administered sequentially in random order ibuprofen, sulindac, and diclofenac for one month each, with an intervening two-week washout period between each treatment period. During the washout period, subjects received paracetamol.


METHODS
Hypertension Clinic, Medical Centre, Harare, Zimbabwe.


METHODS
Fifteen female hypertensive women with documented arthritis.


METHODS
Blood pressure at the end of two weeks of paracetamol was compared with blood pressure after one month of treatment with each of the NSAID.


RESULTS
Mean blood pressure was unchanged before and after all NSAIDs: 108 +/- 7 versus 107 +/- 9 for diclofenac, 108 +/- 9 versus 108 +/- 9 for sulindac, and 108 +/- 8 versus 107 +/- 9 for ibuprofen. The 24 hour urinary sodium excretion was not significantly different.


CONCLUSIONS
The three NSAIDs investigated did not neutralise the antihypertensive effect of the combination of lisinopril and HCT, and hence the blood pressure lowering action of the combination may not be prostaglandin dependent.
Bhagat
K
K
Department of Clinical Pharmacology, University of Zimbabwe, Health Science Building, P.O. Box A178, Avondale, Harare, Zimbabwe.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D004008:Diclofenac / Q000494:pharmacology / Q000627:therapeutic use; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy; D007052:Ibuprofen / Q000494:pharmacology / Q000627:therapeutic use; D017706:Lisinopril / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy; D013467:Sulindac / Q000494:pharmacology / Q000627:therapeutic use; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D004008:Diclofenac; D013467:Sulindac; D017706:Lisinopril; D007052:Ibuprofen