title: [A case of chronic hypersensitivity pneumonia with elevation of serum SP-D and KL-6].
abstract: A 73-year-old woman suffering from dyspnea on effort and chronic cough was admitted to our hospital. Chest computed tomography disclosed ground-glass opacities, irregular linear opacities and honeycombing distributed predominantly in the subpleural area. The serum levels of SP-D and KL-6 rose to 889 ng/ml, 1,755 U/ml, respectively. These findings indicated idiopathic pulmonary fibrosis. However, the number of lymphocytes and the CD4/CD8 ratio in the BAL fluid were elevated. Transbronchial lung biopsy specimens demonstrated alveolitis with granuloma formation. The evidence that she had lived in a house with a heavy fungal growth and that tests of precipitation in response to Penicillium corylophilum were positive confirmations of a diagnosis of chronic hypersensitivity pneumonia.
authors.affiliation: Third Department of Internal Medicine, University School of Medicine, Sapporo, 060-8543, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Gen
authors.initials: G
authors.lastname: Yamada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Nakajima
authors.forename: Shintaro
authors.initials: S
authors.lastname: Tanaka
authors.forename: Shiho
authors.initials: S
authors.lastname: Morita-Ichimura
authors.forename: Ryuji
authors.initials: R
authors.lastname: Takahashi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Sato
authors.forename: Takashi
authors.initials: T
authors.lastname: Shibusa
authors.forename: Shosaku
authors.initials: S
authors.lastname: Abe
mesh_terms: D000368:Aged; D000542:Alveolitis, Extrinsic Allergic / Q000097:blood / Q000382:microbiology*; D000941:Antigens; D000951:Antigens, Neoplasm; D002908:Chronic Disease; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000097:blood*; D018396:Mucin-1; D009077:Mucins; D009181:Mycoses / Q000097:blood*; D010407:Penicillium; D037663:Pulmonary Surfactant-Associated Protein D; D011663:Pulmonary Surfactants / Q000097:blood*
chemical_list: D000941:Antigens; D000951:Antigens, Neoplasm; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D037663:Pulmonary Surfactant-Associated Protein D; D011663:Pulmonary Surfactants