[DNA content, expression of proliferating cell nuclear antigen and surgical margins in locally advanced laryngeal cancer].
OBJECTIVE
To probe into the relationship between DNA content, PCNA and prognosis.


METHODS
Surgical margins in 34 patients with locally advanced laryngeal cancers were observed by means of antibody to PCNA and DNA content measurements.


RESULTS
The results demonstrated that at neoplasm margins of 1.0, 0.5, and 0 cm, PCNA indices were 8.62%, 17.76% and 50.32% and DNA indices were 0.98, 1.082 and 1.436 respectively. There is a significant difference between 1.0, 0.5 and 0 cm.


CONCLUSIONS
Moderate and severe atypical hyperplasia of epithelium (AHE) was different from mild AHE and simple hyperplasia of epithelium in the biologic behavior of fission, proliferation and so on and surgical margins should be kept outside the area of moderate AHE.
Wang
B
B
First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001.
Xia
L
L
Shi
Q
Q
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000276:immunology; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*
D004273:DNA, Neoplasm; D018809:Proliferating Cell Nuclear Antigen