title: Quality of life of nasopharyngeal carcinoma patients.
abstract: BACKGROUND
  Quality of life (QOL) issues in patients with head and neck carcinoma are of importance beyond the incidence of these tumors because of the impact of the disease and its treatment on external appearance and function of the upper aerodigestive tract. Nasopharyngeal carcinoma (NPC) patients comprise a unique subgroup in whom, to our knowledge, QOL has not been studied directly.
  
  
  METHODS
  Adult patients with NPC treated during the past 15 years at the Chaim Sheba Medical Center with a minimum follow-up of 6 months were included in the current study. Patients were mailed the revised University of Washington quality of life (UW-QOL) questionnaire and data pertaining to their disease were recorded. Patients with recurrent disease or another malignancy or those whose present status could not be ascertained were excluded from the study. QOL scores were analyzed based on treatment, disease stage, and patient age.
  
  
  RESULTS
  Twenty-eight patients of 35 disease-free patients (80%) responded to the questionnaire sent to patients meeting the study criteria. The mean score for general health was 3.1 (range, 1-5). Pain was not a significant factor. Other domains without noteworthy problems were speech and shoulder disability. The majority of patients described their appearance as normal or with minor changes, and questions concerning activity, recreation/entertainment, employment, and swallowing all scored > 70 (range, 0-100). Dry mouth, chewing, and ear problems were of major concern with the majority of patients and affected the QOL indices. Nevertheless, the overall mean QOL score of these patients was rated as "good" (4.2 on a scale of 1-6).
  
  
  CONCLUSIONS
  In the current study, patients with NPC reported ear problems, difficulties in chewing, and dry mouth but their overall QOL appeared to be good. Ear problems such as secretory otitis media should be recognized at the time of presentation and treated. Conformal radiotherapy techniques sparing the salivary glands and temporal bone most likely will be useful in reducing the morbidity associated with treatment.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, the Chaim Sheba Medical Center, Tel Hashomer and the Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel. talmi@attglobal.net
authors.forename: Yoav P
authors.initials: YP
authors.lastname: Talmi
authors.forename: Zeev
authors.initials: Z
authors.lastname: Horowitz
authors.forename: Lev
authors.initials: L
authors.lastname: Bedrin
authors.forename: Michael
authors.initials: M
authors.lastname: Wolf
authors.forename: Gavriel
authors.initials: G
authors.lastname: Chaushu
authors.forename: Jona
authors.initials: J
authors.lastname: Kronenberg
authors.forename: M Raphael
authors.initials: MR
authors.lastname: Pfeffer
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000523:psychology / Q000628:therapy*; D003430:Cross-Sectional Studies; D006233:Persons with Disabilities; D018572:Disease-Free Survival; D004423:Ear / Q000473:pathology; D004651:Employment; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008409:Mastication; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000523:psychology / Q000628:therapy*; D011788:Quality of Life; D012189:Retrospective Studies