title: Whipple disease with supranuclear ophthalmoplegia diagnosed by polymerase chain reaction of cerebrospinal fluid.
abstract: An elderly man developed acute progressive supranuclear ophthalmoplegia and other central nervous system manifestations that suggested Whipple disease. Results of small intestinal biopsy were negative but polymerase chain reaction testing of the cerebrospinal fluid confirmed the diagnosis.
authors.affiliation: Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Lee
mesh_terms: D039903:Actinobacteria / Q000235:genetics / Q000302:isolation & purification*; D000368:Aged; D000900:Anti-Bacterial Agents; D002555:Cerebrospinal Fluid / Q000382:microbiology*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016133:Polymerase Chain Reaction; D012329:RNA, Bacterial / Q000032:analysis; D013494:Supranuclear Palsy, Progressive / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D008061:Whipple Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis
chemical_list: D000900:Anti-Bacterial Agents; D012329:RNA, Bacterial; D015662:Trimethoprim, Sulfamethoxazole Drug Combination