title: [Oro-antral perforations. Desirability of antibiotic support in surgical closure within 24 hours].
abstract: OBJECTIVE
  The routine use of antibiotics in oro-antral perforations is advocated by a number of authors, in order to prevent post-operative complications such as sinusitis. Our aim was to establish wether the preventive use of antibiotics seams to be indicated in the closure of this perforations.
  
  
  METHODS
  A retrospective investigation.
  
  
  METHODS
  The department of Oral and Maxillofacial Surgery and Oral Pathology of the Academic Center for Dentistry Amsterdam (ACTA) and the Free University Hospital Amsterdam.
  
  
  METHODS
  In a retrospective study 46 patients have been investigated, 32 males and 14 females, who underwent a surgical closure of an oro-antral perforation in 1995, within 24 hours after its occurrence, in a department of oral and maxillofacial surgery. Twenty-two patients received preoperative antibiotics and 24 patients were treated without the use of antibiotics.
  
  
  RESULTS
  Three (6.5%) patients had a post-operative sinusitis. In the other 43 patients there were no postoperative complications.
  
  
  CONCLUSIONS
  The preventive use of antibiotics in oro-antral perforations in order to prevent post-operative complications such as sinusitis seams not to be indicated in the closure of this perforations. However, before a final conclusion on this matter can be drawn, a prospective randomized study should be undertaken.
authors.affiliation: Afdeling Mondziekten en Kaakchirurgie/Orale Pathologie, Academisch Centrum Tandheelkunde Amsterdam/Academisch Ziekenhuis, Vrije Universiteit Amsterdam, postbus 7057, 1007 MB Amsterdam.
authors.forename: R A
authors.initials: RA
authors.lastname: Gortzak
authors.forename: I
authors.initials: I
authors.lastname: van der Waal
mesh_terms: D000328:Adult; D000368:Aged; D019072:Antibiotic Prophylaxis; D005260:Female; D006801:Humans; D008297:Male; D015523:Maxillary Sinusitis / Q000517:prevention & control*; D008875:Middle Aged; D009957:Oroantral Fistula / Q000601:surgery*; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*
vernacular_title: Oro-antrale perforaties. Wenselijkheid van antibiotische ondersteuning bij sluiting binnen 24 uur.