title: Intrathecal lidocaine prevents cardiovascular collapse and neurogenic pulmonary edema in a rat model of acute intracranial hypertension.
abstract: Sympathetic hyperactivity during sudden intracranial hypertension leads to cardiovascular instability, myocardial dysfunction, and neurogenic pulmonary edema. Because spinal anesthesia is associated with sympatholysis, we investigated the protective effects of intrathecal lidocaine in a rodent model. Halothane-anesthetized rats were given a 10-microL intrathecal injection of saline (n = 10) or lidocaine 1% (n = 6). A subdural balloon catheter was inflated for 60 s to produce intracranial hypertension. Hemodynamics were monitored, and hearts and lungs were harvested for histological examination. In Saline versus Lidocaine-Treated rats, peak mean arterial blood pressure during balloon inflation was 115 +/- 4 mm Hg versus 78 +/- 8 mm Hg (P < 0.05), mean arterial blood pressure 30 min after balloon deflation was 47 +/- 2 mm Hg versus 67 +/- 3 mm Hg (P < 0.05), and lung weight was 1.54 +/- 0.03 g versus 1.41 +/- 0.04 g (P < 0.05), respectively. Cardiac dysrhythmias and electrocardiographic changes were more frequent in the Saline-Treated group (P < 0.05). Saline-Treated rats had extensive, hemorrhagic pulmonary edema, whereas the Lidocaine-Treated rats had only patchy areas of lung abnormality. Histological changes in the myocardium were rare, and no difference was found between the two groups. We conclude that intrathecal lidocaine prevents cardiovascular collapse and neurogenic pulmonary edema in a rat model of acute intracranial hypertension.
  
  
  CONCLUSIONS
  In a rat model of intracranial balloon inflation, intrathecal lidocaine prevented cardiovascular collapse and neurogenic pulmonary edema. Descending neural pathways are involved in the development of cardiopulmonary complications associated with acute intracranial hypertension.
authors.affiliation: Department of Pharmacology & Toxicology, Queen's University, Kingston, Ontario, Canada.
authors.forename: Sean R R
authors.initials: SR
authors.lastname: Hall
authors.forename: Louie
authors.initials: L
authors.lastname: Wang
authors.forename: Brian
authors.initials: B
authors.lastname: Milne
authors.forename: Sally
authors.initials: S
authors.lastname: Ford
authors.forename: Murray
authors.initials: M
authors.lastname: Hong
mesh_terms: D000208:Acute Disease; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000473:pathology; D004562:Electrocardiography; D006339:Heart Rate; D006439:Hemodynamics / Q000187:drug effects; D007278:Injections, Spinal; D019586:Intracranial Hypertension / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D007427:Intracranial Pressure; D008012:Lidocaine / Q000008:administration & dosage* / Q000494:pharmacology; D008168:Lung / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D011654:Pulmonary Edema / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012769:Shock / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine