[The relationship between anticardiolipin antibodies and fetal intrauterine growth retardation].
To investigate the relationship between anticardiolipin antibodies(ACA) and fetal intrauterine growth retardation(IUGR), serum ACA was determined in 60 pregnant women by enzyme linked immunosorbent assay(ELISA). Binding index(BI) of ACA-IgM or ACA-IgG in cases with IUGR(n = 30) was significantly higher than that in normal pregnant women(n = 30) (P < 0.05). There was no obvious relationship between the weight of neonate and BI of ACA-IgM(r = 0.1904), ACA-IgA(r = 0.1829) or ACA-IgG(r = 0.2013) in IUGR group. Increased ACA-IgM had a negative association with C3 (r = -0.4108, P < 0.05) and C4(r = -0.4092, P < 0.05), respectively. After routine therapy for IUGR during 27-35 weeks' gestation, the weights of neonates were 2436.87 +/- 437.29 gram in ACA-IgG positive group(n = 15) and 2905.33 +/- 195.95 gram in ACA-IgG negative group(n = 15). There was a statistical significance between these two groups(P < 0.01). It is concluded that ACA may play an important role in the pathogenesis of IUGR. The determination of ACA is also useful for early diagnosis and treatment of IUGR.
Wu
J
J
Department of Obstetrics and Gynaecology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Zeng
W
W
Chen
Z
Z
Lu
Y
Y
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D015415:Biomarkers; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005317:Fetal Growth Retardation / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D011247:Pregnancy
D017153:Antibodies, Anticardiolipin; D015415:Biomarkers; D007074:Immunoglobulin G; D007075:Immunoglobulin M