title: HIV-1 transcription: activation mediated by acetylation of Tat.
abstract: Acetylation of HIV-1 Tat stimulates transcriptional elongation by dissociating Tat from TAR, a transactivation response RNA element in nascent HIV-1 transcripts. In the March issue of Molecular Cell, Mujtaba et al. show that the bromodomain of PCAF acetylase specifically binds to acetylated Tat and leads to dissociation of Tat from TAR.
authors.affiliation: Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nakatani
mesh_terms: D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D015696:Gene Products, tat / Q000378:metabolism*; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics*; D051548:Histone Acetyltransferases; D006801:Humans; D008957:Models, Genetic; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D014158:Transcription, Genetic; D054322:tat Gene Products, Human Immunodeficiency Virus
chemical_list: D015696:Gene Products, tat; D029701:Saccharomyces cerevisiae Proteins; D054322:tat Gene Products, Human Immunodeficiency Virus; D000123:Acetyltransferases; D051548:Histone Acetyltransferases