title: Effects of timolol and dorzolamide on retrobulbar hemodynamics in patients with newly diagnosed primary open-angle glaucoma.
abstract: The authors considered a group of patients with newly diagnosed primary open-angle glaucoma studying the effects of a 4-week treatment with timolol or dorzolamide on retrobulbar vessels. Ocular hemodynamics were assessed by means of color Doppler imaging of the ophthalmic artery, the temporal short posterior ciliary arteries (SPCAs) and the central retinal artery. For each vessel, systolic and diastolic blood flow velocities were measured, and the resistivity index (RI) was calculated. The only significant result was a reduction of temporal SPCA RI after dorzolamide treatment in comparison with baseline (p = 0.011). In the same group, dorzolamide treatment had a slight and nonsignificant increase in temporal SPCA diastolic velocity. The resistance decrease observed after dorzolamide treatment in the ciliary circulation may be due to the decrease in intraocular pressure or a possible direct vasodilating effect of the drug.
authors.affiliation: Department of Oto-Neuro-Ophthalmological Surgery, Section of Ophthalmology, University of Florence, Italy. fernando.galassi@unifi.it
authors.forename: Fernando
authors.initials: F
authors.lastname: Galassi
authors.forename: Andrea
authors.initials: A
authors.lastname: Sodi
authors.forename: Giulia
authors.initials: G
authors.lastname: Renieri
authors.forename: Francesca
authors.initials: F
authors.lastname: Ucci
authors.forename: Benedetta
authors.initials: B
authors.lastname: Pieri
authors.forename: Alon
authors.initials: A
authors.lastname: Harris
authors.forename: Brent
authors.initials: B
authors.lastname: Siesky
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use*; D019842:Ciliary Arteries / Q000000981:diagnostic imaging / Q000502:physiology; D004311:Double-Blind Method; D005123:Eye / Q000098:blood supply*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging / Q000502:physiology; D012161:Retinal Artery / Q000000981:diagnostic imaging / Q000502:physiology; D013449:Sulfonamides / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*; D013999:Timolol / Q000627:therapeutic use*; D018615:Ultrasonography, Doppler, Color
chemical_list: D000319:Adrenergic beta-Antagonists; D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D013876:Thiophenes; D013999:Timolol; C062765:dorzolamide