The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents.
The active form of vitamin D, 1,25-dihydroxyvitamin D(3)[1,25(OH)(2)D(3)], is a secosteroid hormone that regulates calcium and bone metabolism, controls cell proliferation and differentiation, and exerts immunoregulatory activities. This range of functions has been exploited clinically to treat a variety of conditions, from secondary hyperparathyroidism to osteoporosis, to autoimmune diseases such as psoriasis. Recent advances in understanding 1,25(OH)(2)D(3) functions and novel insights into the mechanisms of its immunomodulatory properties suggest a wider applicability of this hormone in the treatment of autoimmune diseases and allograft rejection.
Mathieu
Chantal
C
LEGENDO, Katholieke Universiteit, Leuven, Belgium.
Adorini
Luciano
L
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D000938:Antigen-Presenting Cells / Q000187:drug effects / Q000378:metabolism; D001327:Autoimmune Diseases / Q000188:drug therapy; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D006084:Graft Rejection / Q000188:drug therapy; D006801:Humans; D008954:Models, Biological; D015394:Molecular Structure; D018167:Receptors, Calcitriol / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects
D000276:Adjuvants, Immunologic; D018167:Receptors, Calcitriol; D002117:Calcitriol