Diagnostic techniques for clinical investigation of laboratory zebrafish.
Unexpected morbidity and mortality of aquatic animal models represent a significant problem for researchers. The authors outline the basic procedures used to diagnose disease outbreaks in laboratory zebrafish colonies, and provide a basic framework for initiating clinical investigations.
Astrofsky
Keith M
KM
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave., Building 16-820, Cambridge, MA 02139, USA.
Harper
Claudia M
CM
Rogers
Arlin B
AB
Fox
James G
JG
D000818:Animals; D000830:Animals, Laboratory; D019411:Clinical Laboratory Techniques / Q000662:veterinary*; D004196:Disease Outbreaks / Q000662:veterinary*; D005393:Fish Diseases / Q000175:diagnosis*; D006652:Histological Techniques; D015027:Zebrafish