Serotonin 2a receptor T102C polymorphism and impaired impulse control.
Patients homozygous for the C allele of the T102C serotonin (5-HT) 2a receptor polymorphism have shown increased suicidal ideation or behavior in some reports, but not in others. We conducted a pilot investigation to determine whether this polymorphism might relate more specifically to a dimension of impaired impulse control, which may underlie only a portion of suicides. Rates of commission (impulsive) errors in a variant of the Continuous Performance Test (CPT) were compared across the genotypes of the T102C polymorphism in adults recruited from the community. The 102C/102C genotype was jointly associated with a greater incidence of past mood disorder or substance-use disorder, as well as significantly more commission errors compared to the 102T/102C and 102C/102C genotypes. These preliminary data suggest that the T102C 5-HT2a receptor polymorphism may be a marker for impaired behavior control-perhaps in the context of psychiatric disorder history.
Bjork
James M
JM
Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, University of Texas-Houston Medical School, Houston, Texas 77030, USA.
Moeller
F Gerard
FG
Dougherty
Donald M
DM
Swann
Alan C
AC
Machado
Mirta A
MA
Hanis
Craig L
CL
D000328:Adult; D000704:Analysis of Variance; D004247:DNA / Q000235:genetics; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000235:genetics* / Q000523:psychology; D005260:Female; D005838:Genotype; D006801:Humans; D007175:Impulsive Behavior / Q000523:psychology; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000523:psychology; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D019966:Substance-Related Disorders / Q000523:psychology
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D004247:DNA