title: The efficacy of valsartan in essential hypertension and its effects on left ventricular hypertrophy.
abstract: Recent studies demonstrate that, treatment with angiotensin-converting enzyme (ACE) inhibitors and angiotensin-II receptor blockers may decrease left ventricular hypertrophy (LVH) in hypertensive patients. We wanted to assess the efficacy of valsartan on echocardiographic variables of LVH in 30 mild to moderate hypertensive patients. Valsartan was found effective in controlling hypertension, also echocardiographic indices of LVH such as interventricular septum and posterior wall thickness were reduced and left ventricular mass decreased significantly. Thus valsartan favorably influences cardiac structure in hypertensive patients.
authors.affiliation: Istanbul University, Institute of Cardiology, Turkey. hasimmutlu@hotmail.com
authors.forename: Haşim
authors.initials: H
authors.lastname: Mutlu
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozhan
authors.forename: Bariş
authors.initials: B
authors.lastname: Okçün
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Okuyan
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Yigit
authors.forename: Cennet
authors.initials: C
authors.lastname: Erbaş
authors.forename: M Serdar
authors.initials: MS
authors.lastname: Küçükoglu
authors.forename: Nazmi
authors.initials: N
authors.lastname: Gültekin
authors.forename: Sinan
authors.initials: S
authors.lastname: Uner
authors.forename: Serap
authors.initials: S
authors.lastname: Erdine
authors.forename: Ozen
authors.initials: O
authors.lastname: Güven
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D015331:Cohort Studies; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000473:pathology; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008875:Middle Aged; D013777:Tetrazoles / Q000008:administration & dosage* / Q000494:pharmacology; D013810:Therapeutic Equivalency; D016896:Treatment Outcome; D014463:Ultrasonography; D014633:Valine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000494:pharmacology; D000068756:Valsartan
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D013777:Tetrazoles; D000068756:Valsartan; D014633:Valine