title: A new integron carrying VIM-2 metallo-beta-lactamase gene cassette in a Serratia marcescens isolate.
abstract: Serratia marcescens is an important nosocomial pathogen which is often resistant to multiple antimicrobial agents. An imipenem-resistant S. marcescens isolate from a urine specimen was found to carry a bla(VIM-2) gene cassette on a class 1 integron. This finding indicates that bla(VIM-2) is presently spreading even to Serratia spp. in Korea, which could compromise the usefulness of carbapenem in the treatment of multi-resistant Gram-negative bacilli infections. Clinical laboratory should be able to detect the VIM-2-producing isolates with even low carbapenem MIC.
authors.affiliation: Department of Clinical Pathology, Research Institute of Bacterial Resistance, and Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, C.P.O. Box 8044, Seoul, Korea.
authors.forename: Jong Hwa
authors.initials: JH
authors.lastname: Yum
authors.forename: Dongeun
authors.initials: D
authors.lastname: Yong
authors.forename: Kyungwon
authors.initials: K
authors.lastname: Lee
authors.forename: Hyon-Suk
authors.initials: HS
authors.lastname: Kim
authors.forename: Yunsop
authors.initials: Y
authors.lastname: Chong
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007723:Korea; D008826:Microbial Sensitivity Tests; D016254:Mutagenesis, Insertional; D016133:Polymerase Chain Reaction; D011995:Recombination, Genetic / Q000235:genetics*; D012706:Serratia marcescens / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics* / Q000302:isolation & purification; D001618:beta-Lactamases / Q000235:genetics*; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; C417264:VIM-1 metallo-beta-lactamase; D001618:beta-Lactamases