Efficient loading of sulfonamide safety-catch linkers by Fmoc amino acid fluorides.
[reaction: see text] Fmoc-protected amino acid fluorides were found to be excellent reagents for the acylation of sulfonamide safety-catch linkers (SCL) suitable for the subsequent preparation of peptide C-terminal thioesters. High loadings were obtained on different types of resins with low levels of epimerization.
Ingenito
Raffaele
R
Jerini AG, Rudower Chaussee 29, 12489 Berlin, Germany. ingenito@jerini.com
Dreznjak
Dijana
D
Guffler
Stefan
S
Wenschuh
Holger
H