[Unexpected drug-interaction].
The case of a male patient suffering from chronic normal pressure hydrocephalus is outlined. Antidepressant and pravastatin were administered because of the patient's abulia and hypercholesterolemia, but neuroleptic malignant syndrome-like conditions developed. All physicians should suppose the occurrence of such an "unexpected drug-interaction" in any case. The author considered that a good sense of careful discernment and rapid reference system of medical information are "essential tools" for clinical management.
Tajima
Yutaka
Y
Clinical Laboratory, Saga Medical School Hospital, Saga 849-8501.
D000368:Aged; D000657:Amoxapine / Q000009:adverse effects*; D000924:Anticholesteremic Agents / Q000009:adverse effects*; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000139:chemically induced; D008297:Male; D008803:Mianserin / Q000009:adverse effects*; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology*; D017035:Pravastatin / Q000009:adverse effects*
D000924:Anticholesteremic Agents; D018687:Antidepressive Agents, Second-Generation; D008803:Mianserin; D017035:Pravastatin; D000657:Amoxapine