title: Excellent booster response 4-6 y after a single primary dose of an inactivated hepatitis A vaccine.
abstract: We studied the immune response of an inactivated hepatitis A vaccine (Havrix 1440) given to middle-aged travellers 4-6 y after a single, primary dose. Anti-HAV antibodies in serum were checked before and 28-35 d after the booster. All 25 vaccinees showed an impressive anamnestic booster response (geometric mean titres 32 and 2993 mIU/ml before and after the booster, respectively). The study confirms experimental data indicating that I dose of inactivated hepatitis A vaccine induces a long-term proliferative T-cell response in addition to producing anti-HAV antibody. As recall memory for this vaccine is elicited several years after a single dose there is probably no need for a second vaccine dose.
authors.affiliation: Department of Clinical Virology, Institute of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: Sten
authors.initials: S
authors.lastname: Iwarson
authors.forename: Magnus
authors.initials: M
authors.lastname: Lindh
authors.forename: Lena
authors.initials: L
authors.lastname: Widerström
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D022362:Hepatitis A Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D030041:Hepatitis A virus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood / Q000276:immunology; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D008875:Middle Aged; D012698:Serologic Tests; D013997:Time Factors; D014195:Travel
chemical_list: D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies