title: Obstructive sleep apnoea and urine catecholamines in hypertensive males: a population-based study.
abstract: Studies addressing the relationship between obstructive sleep apnoea (OSA) and sympathoadrenal activity have been criticized for poor control of factors known to confound sympathetic function, including hypertension. The aim of this study was to investigate the relationship between OSA and urinary catecholamines in a population-based sample of hypertensive males. In 1994, 2,668 males aged 40-79 yrs answered a questionnaire regarding sleep disorders and somatic diseases. Of those who reported hypertension, an age-stratified sample of 116 was selected for monitoring of breathing during sleep and overnight urine analysis. Subjects with OSA, defined as apnoea-hypopnoea index > or = 10 x h(-1), had higher concentrations of urinary normetanephrine (182+/-57 versus 141+/-45 micromol x mol(-1) creatinine, p<0.001) and metanephrine (70+/-28 versus 61+/-28 micromol mol(-1) creatinine, p<0.05) in comparison to subjects without OSA. In a multiple regression analysis, there was an association between variables of sleep-disordered breathing and normetanephrine and metanephrine concentrations, independent of major confounding factors. The authors concluded that, in a population-based sample of hypertensive males, obstructive sleep apnoea is associated with increased urinary concentrations of extraneuronal metabolites of catecholamines independent of major confounding factors, suggesting increased sympathoadrenal activity. Elevated sympathoadrenal activity may explain the increased cardiovascular morbidity associated with obstructive sleep apnoea.
authors.affiliation: Dept of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Akademiska sjukhuset, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Elmasry
authors.forename: E
authors.initials: E
authors.lastname: Lindberg
authors.forename: J
authors.initials: J
authors.lastname: Hedner
authors.forename: C
authors.initials: C
authors.lastname: Janson
authors.forename: G
authors.initials: G
authors.lastname: Boman
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D015415:Biomarkers / Q000032:analysis; D002395:Catecholamines / Q000032:analysis* / Q000652:urine*; D016009:Chi-Square Distribution; D002940:Circadian Rhythm; D015897:Comorbidity; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology* / Q000652:urine; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011159:Population Surveillance; D011336:Probability; D011379:Prognosis; D018570:Risk Assessment; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000453:epidemiology* / Q000652:urine; D016482:Urinalysis
chemical_list: D015415:Biomarkers; D002395:Catecholamines