Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor.
Cholecystokinin (CCK) is an important gastrointestinal hormone as well as a neurotransmitter. Two types of CCK receptors, types A and B, have been identified. The CCK-A receptor is involved in satiety, food intake and behavior, whereas the B receptor is involved in anxiety. We recently produced CCK-A, -B and AB receptor knockout mice to study the role of these receptors in energy metabolism. Daily energy intake and expenditure were significantly greater in CCK-BR(-/-) and CCK-AR(-/-)BR(-/-) mice than CCK-AR(-/-) and wild-type [CCK-AR(+/+)BR(+/+)] mice. Relative liver and kidney weights (g/kg body) were significantly greater in CCK-AR(-/-)BR(-/-) mice than in wild-type mice. Energy metabolism and energy turnover were increased in mice with a disruption of the CCK-BR gene, although the underlying mechanism is unknown.
Miyasaka
Kyoko
K
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo-173-0015, Japan. miyasaka@tmig.or.jp
Ichikawa
Mineko
M
Ohta
Minoru
M
Kanai
Setsuko
S
Yoshida
Yuki
Y
Masuda
Masao
M
Nagata
Aki
A
Matsui
Toshimitsu
T
Noda
Tetsuo
T
Takiguchi
Soichi
S
Takata
Yutaka
Y
Kawanami
Takako
T
Funakoshi
Akihiro
A
D000818:Animals; D002149:Energy Intake; D004734:Energy Metabolism / Q000235:genetics*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009929:Organ Size / Q000235:genetics; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin / Q000172:deficiency*
D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin