Determination of propylthiouracil using 1,3-dibromo-5,5-dimethylhydantoin (DBH): analytical methods of pharmacopeias with DBH in respect to environmental and economical concern: part 9.
USP 2000 [The United States Pharmacopeia, Rockville USA, 24th ed., 2000, pp. 1436] and PH. EUR. 1997 [European Pharmacopoeia, third ed., Council of Europe, Strasbourg, 1997, p. 1401] determine propylthiouracil using neutralization titration, whereby 0.1 M silver nitrate and twice boiling is necessary. With the application of 1,3-dibromo-5,5-dimethylhydantoin (DBH), the assay of propylthiouracil can be performed easily, faster and friendlier to environment. A mean deviation of 0.03% and a relative standard deviation of 0.3% are obtained. 5-Bromo-6-propyluracil is formed, when propylthiouracil is determined with DBH.
Hilp
Manfred
M
Institut für Pharmazeutische Chemie der Philipps-Universität, Marbacher Weg 6, D-35032 Marburg, Germany. hilp@mailer.uni-marburg.de
D013956:Antithyroid Agents / Q000032:analysis* / Q000191:economics; D004787:Environmental Pollution / Q000517:prevention & control; D006827:Hydantoins; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D007455:Iodine / Q000032:analysis; D010602:Pharmacopoeias as Topic; D011441:Propylthiouracil / Q000032:analysis* / Q000191:economics; D012835:Silver Nitrate; D012996:Solutions
D013956:Antithyroid Agents; D006827:Hydantoins; D007202:Indicators and Reagents; D012996:Solutions; D011441:Propylthiouracil; D012835:Silver Nitrate; D007455:Iodine; C056578:1,3-dibromo-5,5-dimethylhydantoin