[Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration].
OBJECTIVE
To evaluate the proper clinical dosage of indocyanine green(ICG) in angiography for detecting choroidal neovascularization(CNV) of exudative age-related macular degeneration(AMD).


METHODS
Indocyanine green angiography (IA) was performed using a randomized crossover method with two different doses on two occasions. Ease of detection, side effects and clinical serum data were also evaluated.


RESULTS
Among the 39 eyes, detection of CNV using 12.5 mg and 25 mg was most effective in 21 and 31 eyes respectively, showing a statistically significant difference. Slight vomiting was observed temporarily in one patient who had taken 25 mg.


CONCLUSIONS
A dose of 25 mg is appropriate for detection of CNV of exudative AMD and this dosage raises no safety concerns.
Yuzawa
Mitsuko
M
Department of Ophthalmology, Surugadai Hospital of Nihon University, 1-8-13 Surugadai, Kanda, Chiyoda-ku, Tokyo 101-8309, Japan.
Yoneya
Shin
S
Uyama
Masanobu
M
Takahashi
Kanji
K
Takeda
Muneyasu
M
Shiraga
Fumio
F
Miki
Tokuhiko
T
Shiraki
Kunihiko
K
Hayashi
Kazuhiko
K
Ogura
Yuichiro
Y
Komemushi
Sadao
S
Matsui
Mizuo
M
D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000175:diagnosis*; D018592:Cross-Over Studies; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage*; D008268:Macular Degeneration / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D007208:Indocyanine Green