title: Primary cutaneous diffuse large B-cell lymphoma: a clinicopathologic study of 15 cases.
abstract: Primary cutaneous diffuse large B-cell lymphoma (DLBCL) is an uncommon lymphoma. Some authors have suggested that large B-cell lymphoma can be segregated based on anatomic site, with tumors of the lower extremity being unique. We report 15 cases of primary cutaneous DLBCL. Each case was analyzed immunohistochemically using antibodies specific for CD3, CD5, CD10, CD20, bcl-2, bcl-6, and p53. Polymerase chain reaction analysis for t(14;18)(q32;q21) also was performed. There were 13 men and 2 women (median age, 64 years). Thirteen tumors were composed predominantly of centroblasts, and 2 were immunoblastic. There was a median follow-up of 72 months. Of the 4 patients with primary cutaneous DLBCL of the lower extremity (thigh, knee, leg), 2 (50%) experienced a recurrence and 1 patient died of disease. In the non-lower extremity cases, 18% (2/11) recurred and no patients died of disease. We conclude that primary cutaneous DLBCL usually occurs in elderly patients with a male predominance. Recurrences are common, but death of disease is rare.
authors.affiliation: Department of Clinical Pathology, Cleveland Clinic Foundation, OH 44195, USA.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Hembury
authors.forename: Benita
authors.initials: B
authors.lastname: Lee
authors.forename: Randy D
authors.initials: RD
authors.lastname: Gascoyne
authors.forename: Nicol
authors.initials: N
authors.lastname: Macpherson
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Nancy
authors.initials: N
authors.lastname: House
authors.forename: L Jeffrey
authors.initials: LJ
authors.lastname: Medeiros
authors.forename: Eric D
authors.initials: ED
authors.lastname: Hsi
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D004268:DNA-Binding Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016133:Polymerase Chain Reaction; D011518:Proto-Oncogene Proteins / Q000032:analysis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D051560:Proto-Oncogene Proteins c-bcl-6; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*; D014157:Transcription Factors / Q000032:analysis; D014178:Translocation, Genetic; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D015703:Antigens, CD; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051560:Proto-Oncogene Proteins c-bcl-6; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53