title: Three-dimensional magnetic resonance imaging of lung and liver tumors in mice by use of transversal multislice magnetic resonance images.
abstract: OBJECTIVE
  To diagnose lung and liver tumors experimentally induced in mice in three-dimensional magnetic resonance (MR) images constructed by superimposing transversal multislice MR images of thoracic and abdominal regions taken under a high magnetic field of 7.05 tesla (T).
  
  
  METHODS
  Lung and liver tumors were induced by administration of urethane to A/J mice and implantation of transplantable colon-26 cells into BALB/c mice, respectively. Two-dimensional (2-D) multislice MR images from the thoracic to abdominal regions were taken under the proton density-weighted conditions. Each organ in the 2-D MR images was pseudocolored, and a three-dimensional (3-D) image was constructed by superimposing them on a UNIX computer, using volume-rendering software.
  
  
  RESULTS
  In the normal mouse, each organ in the thoracic and abdominal regions was three-dimensionally imaged and was clearly distinguished from the others. In mice with tumors in the lung or liver, the pathologic changes in the tissue could be visualized in 3-D images.
  
  
  CONCLUSIONS
  The MR images three-dimensionally constructed by use of a method combining MR imaging under a high magnetic field of 7.05 T and a computer technique using volume-rendering software was useful for diagnosis of lung and liver tumors experimentally induced in mice.
authors.affiliation: Laboratory of Radiation Biology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Asanuma
authors.forename: K
authors.initials: K
authors.lastname: Ohkura
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kon
authors.forename: S
authors.initials: S
authors.lastname: Shimokawa
authors.forename: M
authors.initials: M
authors.lastname: Kuwabara
mesh_terms: D000005:Abdomen / Q000033:anatomy & histology; D000818:Animals; D003110:Colonic Neoplasms / Q000473:pathology; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000662:veterinary*; D008114:Liver Neoplasms, Experimental / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D012984:Software; D013047:Specific Pathogen-Free Organisms; D013909:Thorax / Q000033:anatomy & histology