title: Pharmacokinetics of a 24-hour intravenous ketoprofen infusion in children.
abstract: BACKGROUND
  No pharmacokinetic data are available with respect to the plasma concentration of ketoprofen during intravenous infusion in children.
  
  
  METHODS
  We present here the pharmacokinetics of ketoprofen after a 10-min intravenous infusion of 1 mg/kg followed by a 24-h infusion of 4 mg/kg in 18 children aged 7 months to 16 years. Venous blood samples were collected at 5 min, 1, 2, 4, 24 h following the loading dose, and then 1, 2 and 4 h after the end of the infusion. A validated HPLC method was used to measure plasma levels of ketoprofen.
  
  
  RESULTS
  The steady state plasma concentration of ketoprofen was 2.0 microg/mL (range 1.3-2.7 microg/mL). The clearance of ketoprofen was 0.09 L x h(-1) x kg(-1) (range 0.06-0.13 L x h(-1) x kg(-1)). The distribution volume was 0.16 L/kg (range 0.12-0.21 L/kg). The terminal half-life was 1.3 h (range 0.8-1.7 h).
  
  
  CONCLUSIONS
  The pharmacokinetics of ketopofen in children is similar to that reported in adults. Our results indicate that ketoprofen is a feasible drug for continuous intravenous infusion in acute pain treatment in children.
authors.affiliation: Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Finland. hannu.kokki@nam.fi
authors.forename: H
authors.initials: H
authors.lastname: Kokki
authors.forename: M
authors.initials: M
authors.lastname: Karvinen
authors.forename: A
authors.initials: A
authors.lastname: Jekunen
mesh_terms: D000293:Adolescent; D000775:Anesthesia, Spinal; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D007660:Ketoprofen / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D008297:Male; D011446:Prospective Studies; D017409:Sufentanil / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen; D017409:Sufentanil