title: Deglycobleomycin: solid-phase synthesis and DNA cleavage by the resin-bound ligand.
abstract: [structure: see text] A greatly improved solid-phase synthesis of deglycobleomycin using a Dde-based linker is reported. The resin-bound deglycobleomycin could be completely deblocked and assayed for DNA plasmid relaxation, sequence-selective DNA cleavage, and light production from a molecular beacon.
authors.affiliation: Departments of Chemistry and Biology, University of Virginia, Charlottesville, Virginia 22901, USA.
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Smith
authors.forename: Zhi-Fu
authors.initials: ZF
authors.lastname: Tao
authors.forename: Shigeki
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Leitheiser
authors.forename: Xihan
authors.initials: X
authors.lastname: Wu
authors.forename: Sidney M
authors.initials: SM
authors.lastname: Hecht
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D001761:Bleomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D007202:Indicators and Reagents; D008024:Ligands; D008856:Microscopy, Fluorescence; D012116:Resins, Plant
chemical_list: D000903:Antibiotics, Antineoplastic; D007202:Indicators and Reagents; D008024:Ligands; D012116:Resins, Plant; D001761:Bleomycin; C033284:deglycobleomycin; D004247:DNA