Human herpesvirus 6 viremia in bone marrow transplant recipients: clinical features and risk factors.
Human herpesvirus 6 (HHV-6) infection was studied in 82 bone marrow transplant (BMT) recipients (72 allogeneic, 10 autologous). All recipients and 30 donors were seropositive for HHV-6 antibody at the time of bone marrow transplantation. Thirty-one recipients (37.8%) had HHV-6 viremia 2-4 weeks after transplantation. The incidence of HHV-6 viremia was significantly higher among allogeneic BMT recipients than in autologous BMT recipients (P=.011). Therefore, the following analyses of allogeneic BMT recipients were carried out (n=72). Geometric mean antibody titers (log(10)) were significantly higher in recipients without viremia than in those with viremia (1.84+/-0.39 vs. 1.61+/-0.42; P=.022). Logistic regression analysis demonstrated that leukemia or lymphoma is an independent risk factor (P=.031) for HHV-6 viremia. Rash occurring within 1 month after transplantation was observed in 17 (54.8%) of 31 recipients with HHV-6 viremia but in only 8 (19.5%) of 41 recipients without HHV-6 viremia (P=.001).
Yoshikawa
Tetsushi
T
Laboratory of Virology, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, 4668550 Japan. tetsushi@med.nagoya-u.ac.jp
Asano
Yoshizo
Y
Ihira
Masaru
M
Suzuki
Kyoko
K
Ohashi
Masahiro
M
Suga
Sadao
S
Kudo
Kazuko
K
Horibe
Keizo
K
Kojima
Seiji
S
Kato
Koji
K
Matsuyama
Takaharu
T
Nishiyama
Yukihiro
Y
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006566:Herpesviridae Infections / Q000453:epidemiology* / Q000503:physiopathology* / Q000821:virology; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D012307:Risk Factors; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014766:Viremia / Q000821:virology*
D000914:Antibodies, Viral