Antiulcerogenic and analgesic effects of the Austroplenckia populnea extracts in mice.
Austroplenckia populnea (Reiss.) Lund. is a Brazilian Cerrado plant belonging to the Celastraceae family. Hexane and methanol extracts of leaves were investigated for their antiulcerogenic (ethanol and indomethacin/bethanecol induced gastric damage) and analgesic (writhing and tail-flick tests) activities in mice. Acute toxic effects also were evaluated. Oral administration of both extracts at a dose of 1000 mg/kg significantly reduced the total area of the lesion, the relative area of lesion and the ulcerative index in ethanol-induced gastric damage, but both extracts were inactive in the indomethacin/bethanecol-induced gastric damage test. A dose dependent effect was determined with the hexane extract in the ethanol-induced lesions test. The hexane and methanol extracts reduced the number of contortions in the writhing test, but both extracts were inactive in the tail-flick immersion test.
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Laboratory of Phytomedicines, Department of Pharmacology, Instituto de Biociências, Universidade Estadual Paulista (Unesp), Botucatu, CEP 18618-000, State of São Paulo, Brazil.
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D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001938:Brazil; D029753:Celastraceae; D005753:Gastric Mucosa / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D023382:Toxicity Tests, Acute
D000700:Analgesics; D000897:Anti-Ulcer Agents; D010936:Plant Extracts