title: An approach to comparative assessments of potential health risks from exposure to radionuclides and hazardous chemicals.
abstract: The need to compare potential health risks to the public associated with different activities that can result in releases of hazardous substances to the environment is becoming increasingly important in decision-making. In making such comparisons, it is desirable to use equivalent indicators of potential health risks for radionuclides, chemical carcinogens, and noncarcinogenic hazardous chemicals. Current approaches to risk assessment that were developed for purposes of protecting human health do not provide equivalent indicators of potential risks from exposure to radionuclides and hazardous chemicals. Comparisons of environmental concentrations or calculated exposures or risks with standards for protection of public health also do not provide equivalent indicators of potential risks. We propose a simple approach to comparative risk assessments in which calculated exposures to any hazardous substances are expressed relative to no-observed-effect levels (NOELs) or, preferably, lower confidence limits of benchmark doses (BMDLs) in humans. This approach provides an equivalent, science-based indicator of the relative risks posed by different exposures to any hazardous substances.
authors.affiliation: Oak Ridge National Laboratory, TN 37831-6480, USA. dck@senes.com
authors.forename: D C
authors.initials: DC
authors.lastname: Kocher
authors.forename: H
authors.initials: H
authors.lastname: Greim
mesh_terms: D019985:Benchmarking; D004781:Environmental Exposure; D004784:Environmental Monitoring; D015386:Hazardous Substances / Q000009:adverse effects*; D006801:Humans; D011634:Public Health; D011848:Radioactive Pollutants / Q000009:adverse effects*; D012016:Reference Values; D018570:Risk Assessment / Q000379:methods
chemical_list: D015386:Hazardous Substances; D011848:Radioactive Pollutants