title: Severe complications after hypofractionated high dose rate intracavitary brachytherapy following external beam irradiation for oesophageal carcinoma.
abstract: The purpose of this study was to evaluate severe complications that developed after high dose rate (HDR) intracavitary brachytherapy for oesophageal carcinoma. Six consecutive patients with oesophageal carcinoma were treated by external beam irradiation (60 Gy in 30 fractions over 6 weeks) followed by hypofractionated intracavitary HDR brachytherapy (10 Gy in 2 fractions). Two of the six patients were alive and well for more than 2-3 years following therapy, but three of the six patients developed treatment-related oesophageal fistulae and died. HDR intracavitary brachytherapy following external beam irradiation is an effective method for radical treatment of oesophageal carcinoma. However, hypofractionated HDR brachytherapy should be used with care.
authors.affiliation: Departments of Radiology and Pathology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-0042, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hama
authors.forename: M
authors.initials: M
authors.lastname: Uematsu
authors.forename: A
authors.initials: A
authors.lastname: Shioda
authors.forename: A
authors.initials: A
authors.lastname: Suda
authors.forename: S
authors.initials: S
authors.lastname: Aida
authors.forename: S
authors.initials: S
authors.lastname: Kusano
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D004937:Esophageal Fistula / Q000000981:diagnostic imaging / Q000209:etiology; D004938:Esophageal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011832:Radiation Injuries / Q000209:etiology*; D011882:Radiotherapy, High-Energy / Q000009:adverse effects*; D015996:Survival Rate; D014057:Tomography, X-Ray Computed