title: Vestibular dysfunction in the epistatic circler mouse is caused by phenotypic interaction of one recessive gene and three modifier genes.
abstract: Vestibular dysfunction is a frequent clinical problem, leading to dizziness and imbalance. Genes play an important role in its etiology, but the genetics are complex and poorly understood. In this study we have analyzed the complex inheritance pattern in the Epistatic circler mouse, which shows circling behavior indicative of vestibular dysfunction in the mouse. This phenotype exists in a proportion of the F2-generation from an intercross between C57L/J and SWR/J mouse strains. Genetic investigation indicates that the circling behavior is caused by a major recessively inherited gene derived from the SWR/J strain (the Ecs-gene) in combination with at least three different modifier genes derived from C57L/J (the Ecl-genes). Genetic mapping made it possible to localize the Ecs-gene to chromosome 14 and the Ecl-genes to chromosome 3, 4, and 13. This study illustrates the feasibility of identifying genes for multifactorial traits in mice.
authors.affiliation: Department of Medical Genetics, University of Antwerp, B-2610 Antwerp, Belgium.
authors.forename: Kim
authors.initials: K
authors.lastname: Cryns
authors.forename: Michiel P
authors.initials: MP
authors.lastname: Van Spaendonck
authors.forename: Kris
authors.initials: K
authors.lastname: Flothmann
authors.forename: Arjan M
authors.initials: AM
authors.lastname: van Alphen
authors.forename: Paul H
authors.initials: PH
authors.lastname: Van De Heyning
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Timmermans
authors.forename: Chris I
authors.initials: CI
authors.lastname: De Zeeuw
authors.forename: Guy
authors.initials: G
authors.lastname: Van Camp
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002874:Chromosome Mapping / Q000379:methods; D003433:Crosses, Genetic; D004843:Epistasis, Genetic; D005808:Genes, Recessive / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics; D005824:Genetics, Behavioral; D005838:Genotype; D006720:Homozygote; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D010641:Phenotype; D015837:Vestibular Diseases / Q000235:genetics*