title: Antispasmodic and antimicrobial diterpenic acids from Viguiera hypargyrea roots.
abstract: Two spasmolytic diterpene acids, ent-beyer-15-en-19-oic acid and ent-kaur-16-en-19-oic acid, have been isolated from the roots of Viguiera hypargyrea by bioassay-guided fractionation. Beyerenoic acid was also active against Staphylococcus aureus, Enterococcus feacalis and Candida albicans.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Zamilpa
authors.forename: Jaime
authors.initials: J
authors.lastname: Tortoriello
authors.forename: Victor
authors.initials: V
authors.lastname: Navarro
authors.forename: Guillermo
authors.initials: G
authors.lastname: Delgado
authors.forename: Laura
authors.initials: L
authors.lastname: Alvarez
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D019659:Asteraceae; D001419:Bacteria / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013293:Enterococcus faecalis / Q000187:drug effects; D005772:Gastrointestinal Transit / Q000187:drug effects; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004224:Diterpenes; D010276:Parasympatholytics; D010936:Plant Extracts; C458719:beyerenoic acid; C051436:kaurenoic acid