Apoptosis in cardiac disease--what is it--how does it occur.
This review will present a summary of a description of apoptotic pathways in the heart, followed by ways to measure it and the experimental and clinical evidence for the role of apoptosis in cardiac disease. An evaluation of the effectiveness of pharmacological and other therapeutic interventions in the prevention of apoptosis in the context of cardiac disease will also be presented.
Neuss
M
M
Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Crow
M T
MT
Chesley
A
A
Lakatta
E G
EG
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D061945:Caspase Inhibitors; D053938:DNA Fragmentation / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D006331:Heart Diseases / Q000150:complications / Q000503:physiopathology*; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000503:physiopathology; D020287:In Situ Nick-End Labeling; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology; D011943:Receptors, Adrenergic, beta / Q000627:therapeutic use; D012084:Renin-Angiotensin System / Q000187:drug effects; D015427:Reperfusion Injury / Q000150:complications / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology
D061945:Caspase Inhibitors; D011943:Receptors, Adrenergic, beta