title: Aberrant expression of intercellular adhesion molecule-1 and killer inhibitory receptors induces immune tolerance in women with pelvic endometriosis.
abstract: OBJECTIVE
  To investigate host immunologic response to endometriosis in terms of intercellular adhesion molecule (ICAM)-1 expression by macrophages and killer cell inhibitory receptor (KIR) expression by natural killer (NK) cells.
  
  
  METHODS
  Case-control study of immunologic markers.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Twenty-eight Japanese women with endometriosis. Control subjects were 26 women without endometriosis. Diagnoses were made at laparoscopy.
  
  
  METHODS
  Venipuncture and laparoscopic peritoneal fluid collection.
  
  
  METHODS
  ICAM-1 expression by macrophages and KIR expression by NK cells, measured by flow cytometry.
  
  
  RESULTS
  In women with endometriosis, expression of ICAM-1 by peritoneal macrophages was significantly lower and expression of KIR by NK cells in peritoneal fluid and peripheral blood was significantly higher than in control subjects.
  
  
  CONCLUSIONS
  Properties of macrophages and NK cells in women with endometriosis promote immunotolerance to implanted tissue in the peritoneal environment. Increased KIR(+)NK cells in peripheral blood may represent a risk factor for endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, Japan. maedan@med.kochi-ms.ac.jp
authors.forename: Nagamasa
authors.initials: N
authors.lastname: Maeda
authors.forename: Chiaki
authors.initials: C
authors.lastname: Izumiya
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Oguri
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Kusume
authors.forename: Yorito
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Takao
authors.initials: T
authors.lastname: Fukaya
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D001202:Ascitic Fluid / Q000166:cytology; D001402:B-Lymphocytes; D016022:Case-Control Studies; D004715:Endometriosis / Q000276:immunology* / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007108:Immune Tolerance; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis*; D007694:Killer Cells, Natural / Q000737:chemistry / Q000276:immunology; D007958:Leukocyte Count; D017737:Macrophages, Peritoneal / Q000737:chemistry / Q000276:immunology; D009000:Monocytes; D010532:Peritoneal Diseases / Q000276:immunology / Q000378:metabolism; D011971:Receptors, Immunologic / Q000032:analysis*; D054340:Receptors, KIR; D013601:T-Lymphocytes
chemical_list: D000911:Antibodies, Monoclonal; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D018799:Intercellular Adhesion Molecule-1