Moyamoya syndrome: impaired hemodynamics on ECD SPECT after EEG controlled hyperventilation.
OBJECTIVE
Ischemic symptoms in children with Moyamoya syndrome are typically provoked by hyperventilation (HV) and are accompanied by the "re-build-up" phenomenon in EEG. The value of scintigraphic detection of HV-provoked perfusion deficits remains to be elucidated.


METHODS
In seven children with Moyamoya syndrome regional cerebral blood flow was assessed by 99mTc-ethyl-cysteine-dimer (ECD) single photon emission computed tomography (SPECT) after HV and under baseline conditions to identify ischemia prone regions.


RESULTS
Regional marked hypoperfusion after HV was found in all patients. Predominant perfusion deficits were detected in the frontal lobes.


CONCLUSIONS
ECD SPECT is a potential tool for the preoperative evaluation of cerebral hemodynamics and for monitoring angiosurgical therapies in Moyamoya disease.
Matheja
P
P
Department of Nuclear Medicine, Münster University, Germany.
Weckesser
M
M
Debus
O
O
Franzius
Ch
Ch
Löttgen
J
J
Schober
O
O
Kurlemann
G
G
D000293:Adolescent; D017668:Age of Onset; D001921:Brain / Q000000981:diagnostic imaging; D002648:Child; D003545:Cysteine / Q000031:analogs & derivatives*; D004569:Electroencephalography; D006439:Hemodynamics; D006801:Humans; D006985:Hyperventilation / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009072:Moyamoya Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine