title: Highly active antiretroviral therapy and cervical intraepithelial neoplasia.
abstract: Highly active antiretroviral therapy (HAART) has improved HIV prognosis, but its effect on cervical intraepithelial neoplasia (CIN), which is associated with HIV, is uncertain. Among 71 HAART-treated women the prevalence of CIN before HAART was 55%. After a median of 10 months after starting HAART the prevalence had increased to 62% (P = 0.20); 13% of patients experienced regression of a CIN lesion, and this was most strongly associated with a greater increase in CD4 cell count. Such studies will provide the basis for guidelines for monitoring CIN in HIV-positive women in the HAART era.
authors.affiliation: Center for HIV Medicine, Royal Free Hospital, London, UK.
authors.forename: Antonia L
authors.initials: AL
authors.lastname: Moore
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Sabin
authors.forename: Sara
authors.initials: S
authors.lastname: Madge
authors.forename: Amanda
authors.initials: A
authors.lastname: Mocroft
authors.forename: Wendy
authors.initials: W
authors.lastname: Reid
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Johnson
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D017410:Practice Guidelines as Topic; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000188:drug therapy*