Azaberbene derivatives as alpha 2A-adrenoceptor antagonists.
The synthesis of octahydro-8H-isoquino[2,1-g][1,6]naphthyridine derivatives 2a-f was carried out. These new compounds are selective alpha 2A-adrenoceptor antagonists.
Szántay
Csaba
C
Institute of Organic Chemistry, Budapest University of Technology and Economics and Hungarian Academy of Sciences Research Group for Alkaloid Chemistry, Budapest, Hungary, Szent Gellért tér 4., H-1521. szantay.szk@chem.bme.hu
Szabó
Lajos
L
Zsilla
Gabriella
G
Vizi
Sylvester E
SE
D058669:Adrenergic alpha-2 Receptor Antagonists; D000818:Animals; D006168:Guinea Pigs; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D014649:Vas Deferens / Q000187:drug effects
D058669:Adrenergic alpha-2 Receptor Antagonists; D006576:Heterocyclic Compounds, 4 or More Rings; D009287:Naphthyridines