title: Epithelioid trophoblastic tumor of the uterus: cytological and immunohistochemical observation of a case.
abstract: Epithelioid trophoblastic tumor (ETT) is a new entity of trophoblastic tumor and 14 such cases were reported by Shih and Kurman in 1998. However, only three subsequent cases supporting ETT have been reported. Recently, we experienced a case of ETT in a 37-year-old woman whose preoperative endometrial brushings showed atypical mononucleate giant cells and who underwent hysterectomy with the diagnosis of a uterine fibroid. The specimens revealed a 2.5 x 3.0 cm yellow-tan intramural nodule located in the lower uterine segment, which was composed of a neoplastic proliferation of intermediate trophoblasts in epithelioid arrangements. Immunohistochemically, the tumor cells were diffusely positive for cytokeratin and inhibin-alpha, and focally positive for human chorionic gonadotropin and human placental lactogen. She presented an uneventful clinical course as of September 2001.
authors.affiliation: Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan. skamoi@nms.ac.jp
authors.forename: Seiryu
authors.initials: S
authors.lastname: Kamoi
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Ohaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Mori
authors.forename: Munehiro
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Youko
authors.initials: Y
authors.lastname: Kawamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawamura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Araki
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000032:analysis; D015622:Epithelioid Cells / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000032:analysis; D007633:Keratins / Q000032:analysis; D010928:Placental Lactogen / Q000032:analysis; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000378:metabolism / Q000473:pathology*; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D006063:Chorionic Gonadotropin; D007265:Inhibins; D007633:Keratins; D010928:Placental Lactogen