Lack of association between the apolipoprotein E genotype and depression in Alzheimer's disease.
The epsilon4 allele of apolipoprotein (apo E) is one of the risk factors for late-onset Alzheimer's disease (AD). We evaluated the association between apo E genotypes and depression in patients with AD. A psychiatrist interviewed all patients and their caregivers for depression using a Chinese version of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, and for the severity of depression using the Hamilton Depression Rating Scale (HDRS). Twenty-five of the 149 patients with AD were diagnosed with depressive disorders. The numbers of patients in each apo E genotype were 10 in epsilon2/3, 2 in epsilon2/4, 74 in epsilon3/3, 46 in epsilon3/4, and 17 in epsilon4/4. We did not find an association between depression and the presence or absence of the epsilon4 or epsilon2 allele. The HDRS scores were not different in patients with AD with the epsilon4 or epsilon2 allele or in those patients without them. Our study did not find an association between depression and the apo E epsilon4 or epsilon2 allele in AD.
Liu
Chia-Yih
CY
Department of Psychiatry, Chang Gung University School of Medicine and Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Hong
Chen-Jee
CJ
Liu
Tsung-Yun
TY
Lin
Ker-Neng
KN
Wang
Pei-Neng
PN
Chi
Chin-Wen
CW
Chuang
Ya-Yun
YY
Liu
Hsiu-Chih
HC
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics* / Q000523:psychology; D001057:Apolipoproteins E / Q000235:genetics*; D017028:Caregivers; D003863:Depression / Q000209:etiology* / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors
D001057:Apolipoproteins E