title: Distinctive distribution of AIM1 polymorphism among major human populations with different skin color.
abstract: The genetic background for human skin color has been a major topic in human genetics; however, its molecular basis is still unclear. The gene for the AIM-1 protein (AIM1) was recently found to be responsible for the body color of medaka fish. In the search for the genes controlling human skin color variations, we have investigated genetic polymorphisms of this gene, and we have found a single-nucleotide polymorphism that has clear association with major human populations in terms of skin color.
authors.affiliation: Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakayama
authors.forename: Shoji
authors.initials: S
authors.lastname: Fukamachi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Koda
authors.forename: Augustinus
authors.initials: A
authors.lastname: Soemantri
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ishida
mesh_terms: D000818:Animals; D003459:Crystallins; D005787:Gene Frequency; D005828:Genetics, Population; D005869:Ghana; D006071:Gorilla gorilla / Q000235:genetics; D006801:Humans; D007564:Japan; D008251:Macaca / Q000235:genetics; D008565:Membrane Proteins; D020125:Mutation, Missense; D009512:New Guinea; D019974:Pan paniscus / Q000235:genetics; D002679:Pan troglodytes / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011148:Pongo pygmaeus / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D044469:Racial Groups / Q000235:genetics; D012880:Skin Pigmentation / Q000235:genetics*; D013019:South Africa; D044465:White People / Q000235:genetics
chemical_list: C105445:CRYBG1 protein, human; D003459:Crystallins; D008565:Membrane Proteins; D011506:Proteins