Remodeled-matrix contraction by fibroblasts: numerical investigations.
It is well known that the fibroblast-collagen-matrix contraction model is a unique way to study mechanical interactions that regulate wound contraction of connective tissue cells. This contraction, due to cell traction, plays important roles in wound healing and pathological contractures. A continuum model initially used for the study of mesenchymal morphogenesis is revisited and numerically investigated by assuming that the extracellular matrix has adaptive-elastic properties. The set of non-linear partial differential equations is solved numerically by a finite difference method and the obtained results are discussed.
Ramtani
S
S
Laboratoire de Biomécanique Biomatériaux Osseux et Articulaires-UMR CNRS 7052, Faculté des Sciences et Technologie, Université Paris XII Val de Marne, 61 Avenue du Général de Gaulle, 94010 Cedex, Creteil, France. ramtani@univ-paris12.fr
Fernandes-Morin
E
E
Geiger
D
D
D000818:Animals; D001696:Biomechanical Phenomena; D002921:Cicatrix / Q000503:physiopathology; D003094:Collagen / Q000502:physiology; D003286:Contracture / Q000503:physiopathology; D005109:Extracellular Matrix / Q000502:physiology*; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D009716:Numerical Analysis, Computer-Assisted; D014945:Wound Healing / Q000502:physiology*
D003094:Collagen