title: Antibiotic prophylaxis in clean neurosurgery.
abstract: Two regimens of antibiotic prophylaxis are in use at our institution. These protocols consist in perioperative administration of a single dose of amoxicillin-clavulanic acid of 2.2 g at induction and 8 h later and irrigation of the surgical wound with rifamycin before closure. In cases of dirty surgery, placement of external shunts or foreign bodies, we administer vancomycin 1.5 g/die and ceftazidime 6 g/die for 72 h. A retrospective study of all the clean operations we performed in the last 2 years yielded a total of 793 consecutive procedures with three postoperative wound infections. These results are in agreement with the majority of series reported in literature, although different prophylactic protocols are applied and in some cases no prophylactic antibiotics are administered at all. The use of these agents in clean neurosurgery remains, as a matter of fact, controversial. In order to further investigate this issue we took three or more intraoperative samples for culture in 40 clean cases. Only in 2% of these samples were cultures positive. Although lacking statistical significance, these results are interesting indications of the appropriateness of antimicrobial prophylaxis in clean neurosurgery and invite further investigation in that direction.
authors.affiliation: Department of Neurosurgery, University of Florence, Italy. francesco@cacciola.org
authors.forename: F
authors.initials: F
authors.lastname: Cacciola
authors.forename: F
authors.initials: F
authors.lastname: Cioffi
authors.forename: P
authors.initials: P
authors.lastname: Anichini
authors.forename: N
authors.initials: N
authors.lastname: Di Lorenzo
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001927:Brain Diseases / Q000601:surgery*; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D006801:Humans; D019635:Neurosurgical Procedures; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014640:Vancomycin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D019980:Amoxicillin-Potassium Clavulanate Combination