[Genetics of human narcolepsy].
Narcolepsy is known to be a complex disorder; both genetic and environmental factors play a role in its pathophysiology. Although narcolepsy presents one of the tightest association with a specific HLA antigen (DQB1*0602), there is strong evidence that non-HLA genes also confer susceptibility, both monoaminergic and hypocretinergic systems seem to be involved and may interfere with the phenotype. Implication of the hypocretin system is well-established in both canine and murine narcolepsy (caused by mutation) and a consistent reduction in hypocretin neuron seems to be the cause of human narcolepsy. An autoimmune process is probable.
Dauvilliers
Y
Y
Service de Neurologie B, 80, avenue Augustin Fliche, Hôpital Gui-de-Chauliac, 34295 Montpellier, France.
Tafti
M
M
Billiard
M
M
D000818:Animals; D004283:Dog Diseases / Q000235:genetics; D004285:Dogs; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D009290:Narcolepsy / Q000235:genetics* / Q000662:veterinary; D010641:Phenotype; D018433:Twin Studies as Topic
D005819:Genetic Markers
Génétique de la narcolepsie humaine.