[Experimental study on effect of bushen qingli huoxue treatment on glomerular extracellular matrix of remnant kidney in rats].
OBJECTIVE
To study the effect of Bushen Qingli Huoxue (BQH) treatment on glomerular extracellular matrix (ECM) and in retarding glomerular sclerosis in rats and to explore the mechanism and key of regulation.


METHODS
Animal model was established by 5/6 nephrectomy and the study was carried out by using immune histochemical and pathological methods. Treatment of BQH started 1 week after operation.


RESULTS
After being treated with BQH, the serum creatinine (SCr), blood urea nitrogen (BUN) and urinary protein excretion reduced markedly. Pathological examination showed accumulation of ingredients of glomerular ECM such as type I, IV collagen and laminin decreased significantly, the number of glomerular cells and proliferation cell nuclear antigen positive cells also decreased obviously, and showed that the glomerular sclerosis was retarded. The effect of BQH was similar to that of Enapril, but superior to that of Enapril in reducing BUN and SCr.


CONCLUSIONS
BQH has the effects of reducing ECM accumulation, improving renal function and retarding glomerular sclerosis.
Yang
X
X
Hunan Medical College of TCM, Changsha 410007.
Wei
Y
Y
Liu
X
X
D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005109:Extracellular Matrix / Q000473:pathology*; D008297:Male; D009392:Nephrectomy; D009400:Nephrosclerosis / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D003404:Creatinine