Antinociceptive activity of the natural piperidine alkaloid hydrochlorides from Syphocampylus verticellatus.
In addition to 3'-methoxyluteolin and mixtures of sterols and triterpenes, the leaves of Syphocampylus Verticellatus yielded two piperidine alkaloid hydrochlorides, one of them has a novel structure. The alkaloids exhibit antinociceptive activity.
Miguel
Obdulio G
OG
Departamento de Farmacia, Universidade Federal do Paraná, Curitiba, Brazil.
Santos
Adair R S
AR
Calixto
João B
JB
Delle Monache
Franco
F
Yunes
Rosendo A
RA
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000700:Analgesics / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D001938:Brazil; D005557:Formaldehyde; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D008968:Molecular Conformation; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010880:Piperidines / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification
D000470:Alkaloids; D000700:Analgesics; D010880:Piperidines; D010936:Plant Extracts; D013261:Sterols; D014315:Triterpenes; D005557:Formaldehyde