title: Interleukin-5 and eosinophils as therapeutic targets for asthma.
abstract: Extensive clinical investigations have implicated eosinophils in the pathogenesis of asthma. In a recent clinical trial, humanized monoclonal antibody to interleukin (IL)-5 significantly limited eosinophil migration to the lung. However, treatment did not affect the development of the late-phase response or airways hyperresponsiveness in experimental asthma. Although IL-5 is a key regulator of eosinophilia and attenuation of its actions without signs of clinical improvement raises questions about the contribution of these cells to disease, further studies are warranted to define the effects of anti-IL-5 in the processes that lead to chronic asthma. Furthermore, eosinophil accumulation into allergic tissues should not be viewed as a process that is exclusively regulated by IL-5 but one in which IL-5 greatly contributes. Indeed, data on anti-IL-5 treatments (human and animal models) are confounded by the failure of this approach to completely resolve tissue eosinophilia and the belief that IL-5 alone is the critical molecular switch for eosinophil development and migration. The contribution of these IL-5-independent pathways should be considered when assessing the role of eosinophils in disease processes.
authors.affiliation: Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia. Paul.Foster@anu.edu.au
authors.forename: Paul S
authors.initials: PS
authors.lastname: Foster
authors.forename: Simon P
authors.initials: SP
authors.lastname: Hogan
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Joerg
authors.initials: J
authors.lastname: Mattes
authors.forename: Ian G
authors.initials: IG
authors.lastname: Young
authors.forename: Klaus I
authors.initials: KI
authors.lastname: Matthaei
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Kumar
authors.forename: Surendran
authors.initials: S
authors.lastname: Mahalingam
authors.forename: Dianne C
authors.initials: DC
authors.lastname: Webb
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy*; D016535:Bronchial Hyperreactivity; D004195:Disease Models, Animal; D004802:Eosinophilia; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D015848:Interleukin-5 / Q000276:immunology / Q000378:metabolism*; D008168:Lung / Q000276:immunology / Q000473:pathology / Q000502:physiology / Q000503:physiopathology; D008954:Models, Biological
chemical_list: D015848:Interleukin-5