title: Hippocampal expression of the calcium sensor protein visinin-like protein-1 in schizophrenia.
abstract: Hippocampal cytoarchitectural abnormalities may be part of the cerebral substrate of schizophrenia. Amongst the chemical components being abnormal in brains of schizophrenics are altered calcium concentrations and reduced expression of the neurotrophin receptor, trkB. We studied by immunohistochemical methods the distribution of visinin-like protein-1 (VILIP-1), which is a calcium sensor protein and at the same time a trkB mRNA binding protein, in hippocampi of nine schizophrenic patients and nine matched control subjects. In normal hippocampi VILIP-1 immunoreactivity was found in multiple pyramidal cells and interneurons. A portion of VILIP-1 immunoreactive interneurons co-express calretinin (60%) and parvalbumin (<10%). In schizophrenics fewer pyramidal cells but more interneurons were immunostained. Our data point to an involvement of the protein in the altered hippocampal circuitry in schizophrenia.
authors.affiliation: Department of Psychiatry of the University Magdeburg, Leipziger Str. 44, D-39120, Germany.
authors.forename: Hans-Gert
authors.initials: HG
authors.lastname: Bernstein
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Braunewell
authors.forename: Christina
authors.initials: C
authors.lastname: Spilker
authors.forename: Peter
authors.initials: P
authors.lastname: Danos
authors.forename: Bruno
authors.initials: B
authors.lastname: Baumann
authors.forename: Sieglinde
authors.initials: S
authors.lastname: Funke
authors.forename: Silvia
authors.initials: S
authors.lastname: Diekmann
authors.forename: Eckart D
authors.initials: ED
authors.lastname: Gundelfinger
authors.forename: Bernhard
authors.initials: B
authors.lastname: Bogerts
mesh_terms: D000704:Analysis of Variance; D002135:Calcium-Binding Proteins / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007395:Interneurons / Q000737:chemistry / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000096:biosynthesis*; D051596:Neurocalcin; D017966:Pyramidal Cells / Q000737:chemistry / Q000378:metabolism; D044169:Receptors, Calcium-Sensing; D012559:Schizophrenia / Q000378:metabolism*
chemical_list: D002135:Calcium-Binding Proteins; D009419:Nerve Tissue Proteins; D051596:Neurocalcin; D044169:Receptors, Calcium-Sensing; C496688:VSNL1 protein, human