The significance of anti-Müllerian hormone concentration in seminal plasma for spermatogenesis.
BACKGROUND
The function of anti-Müllerian hormone (AMH) in seminal plasma in adulthood is uncertain. We examined the significance of seminal AMH for spermatogenesis.


METHODS
We measured seminal concentrations of AMH in 39 oligozoospermic men (mean age +/- SD, 32.7 +/- 4.3 years) and 10 normal volunteers to examine the association of seminal AMH with spermatogenesis. The seminal concentrations of AMH in oligozoospermic men (149.3 +/- 254.0 pmol/l) were significantly lower than in normal men (249.0 +/- 167.7 pmol/l; P +/- 0.0337). Seminal AMH concentration correlated significantly with sperm concentration (r = 0.339, P = 0.0350) and mean testicular volume (r = 0.440, P = 0.246). The serum concentration of LH (r = - 0.365, P = 0.0241), but not FSH, testosterone or estradiol, correlated significantly with AMH concentration in seminal plasma.


CONCLUSIONS
AMH in seminal plasma may be important for sperm production, and is a good marker for Sertoli cell development.
Fujisawa
Masato
M
Division of Urology, Department of Organ Therapeutics, Kobe University Graduate School of Medicine, Kobe, Japan. masato@med.kobe-u.ac.jp
Yamasaki
Takafumi
T
Okada
Hiroshi
H
Kamidono
Sadao
S
D000328:Adult; D054304:Anti-Mullerian Hormone; D006023:Glycoproteins; D006131:Growth Inhibitors / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009845:Oligospermia / Q000378:metabolism* / Q000473:pathology; D009929:Organ Size; D009994:Osmolar Concentration; D012016:Reference Values; D012661:Semen / Q000166:cytology / Q000378:metabolism*; D013076:Sperm Count; D013091:Spermatogenesis / Q000502:physiology*; D013735:Testicular Hormones / Q000378:metabolism*; D013737:Testis / Q000473:pathology
D006023:Glycoproteins; D006131:Growth Inhibitors; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone; D007986:Luteinizing Hormone