title: Pelvic organ prolapse and connective tissue abnormalities in Korean women.
abstract: OBJECTIVE
  To evaluate the relationship between pelvic organ prolapse in Korean women and joint hypermobility, which suggests a metabolic collagen fiber abnormality.
  
  
  METHODS
  Between March 1998 and March 2000, we investigated 55 patients with prolapse. The prevalence of joint hypermobility, by measuring finger extension angle, and the proportion of patients with joint hypermobility were measured in patients with pelvic organ prolapse and benign gynecologic patients (control group).
  
  
  RESULTS
  In middle-aged women (40-59 years), the average finger extension angles were higher in the POP group than in the control group (50.04 +/- 9.70 degrees vs. 39.50 +/- 12.19 degrees, respectively; P < .05), but in older women there was no significant difference between the two groups (42.84 +/- 13.05 degrees vs. 43.00 +/- 13.34 degrees, respectively; P > .05).
  
  
  CONCLUSIONS
  The prevalence of joint hypermobility was higher in the POP group and with advanced POP stage (III, IV) than in the control group and early POP stage (I, II). Our results suggest that intrinsic connective tissue abnormality is related to the development of pelvic organ prolapse. Further study involving more patients with pelvic organ prolapse is warranted, and molecular studies to determine the genetic basis of pelvic organ prolapse are also required to further elucidate this abnormality.
authors.affiliation: Division of Urogynecology, Department of Obstetrics and Gynecology, Yonsei University, College of Medicine, Seoul, Korea. swbai@yumc.yonsei.ac.kr
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Bai
authors.forename: Byung Hoon
authors.initials: BH
authors.lastname: Choe
authors.forename: Jeong Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Park
mesh_terms: D000328:Adult; D003240:Connective Tissue Diseases / Q000150:complications* / Q000208:ethnology; D005260:Female; D006801:Humans; D007593:Joint Instability / Q000150:complications* / Q000208:ethnology; D007723:Korea / Q000208:ethnology; D008875:Middle Aged; D010388:Pelvis / Q000473:pathology; D012307:Risk Factors; D014596:Uterine Prolapse / Q000208:ethnology / Q000209:etiology* / Q000503:physiopathology