title: Relationships between serum markers of monocyte/macrophage activation in type 1 Gaucher's disease.
abstract: We studied 44 patients with type 1 Gaucher's disease (16 non-treated patients and 28 treated with enzyme replacement therapy). We measured serum levels of chitotriosidase (ChT), neopterin, angiotensin-converting enzyme (ACE), adenosine deaminase (ADA) and beta-hexosaminidase (Hex) and its major isoenzymes Hex A and Hex B. In the untreated group of patients, the increase in serum levels was ChT>neopterin>ACE> ADA>Hex, with all decreasing significantly in treated patients (p< 0.001). Highly significant correlations were obtained between the markers of monocyte/macrophage activation which were tested (p<0.001). However, partial correlations between serum Hex B (with Hex A constant) and ChT, ACE, neopterin and ADA did not reach statistical significance. This suggests that hepatocytes are the major cellular source of this isoenzyme. Similarly, partial correlation of ChT with neopterin, with the other variables constant, was not significant, which would suggest a different expression of these two markers in Gaucher's disease.
authors.affiliation: Laboratorio Central, Hospital Clinico Universitario, Santiago de Compostela, Spain.
authors.forename: J Antonio
authors.initials: JA
authors.lastname: Casal
authors.forename: Lúcia
authors.initials: L
authors.lastname: Lacerda
authors.forename: Luis F
authors.initials: LF
authors.lastname: Pérez
authors.forename: Rui A
authors.initials: RA
authors.lastname: Pinto
authors.forename: M
authors.initials: M
authors.lastname: Clara Sá Miranda
authors.forename: J
authors.initials: J
authors.lastname: Carlos Tutor
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005776:Gaucher Disease / Q000097:blood* / Q000201:enzymology / Q000276:immunology*; D054818:Hexosaminidase A; D054819:Hexosaminidase B; D006596:Hexosaminidases / Q000097:blood; D006801:Humans; D008262:Macrophage Activation; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000097:blood; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D001619:beta-N-Acetylhexosaminidases / Q000097:blood
chemical_list: D015415:Biomarkers; D019798:Neopterin; D006596:Hexosaminidases; C086400:chitotriosidase; D054818:Hexosaminidase A; D054819:Hexosaminidase B; D001619:beta-N-Acetylhexosaminidases; D007703:Peptidyl-Dipeptidase A; D000243:Adenosine Deaminase