title: [Effect of diazepam on fetus after intravenous administration during the active phase in labour].
abstract: To investigate the effects of diazepam on fetal heart rate and Apgar scoring administered intravenously during the active phase in labour, sixty-two normal term parturients during the active phase of labour with the cervical dilation to 3-5 cm were randomly divided into two groups, diazepam group (n = 32) and control group (n = 30). In diazepam group, 10 mg diazepam was administered intravenously. The concentrations of diazepam in maternal and cord serum were measured by high performance liquid chromatography after birth and the fetal heart rates were monitored by electronic monitor before or after administration of diazepam and Apgar scores were determined immediately after birth. The results showed that the mean level of diazepam in umbilical cord serum was markedly higher than that of maternal serum. Fetal heart base line mutation in diazepam group was weaker than that of the control group. Apgar scores in the neonates of diazepam group was lower than those of the control group. The results indicate that the use of diazepam in pregnant women during active phase of labour may cause depression of fetus.
authors.affiliation: Department of Obstetrics and Gynecology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Cheng
authors.forename: J
authors.initials: J
authors.lastname: Liang
mesh_terms: D000328:Adult; D001034:Apgar Score; D003975:Diazepam / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006340:Heart Rate, Fetal / Q000187:drug effects*; D006801:Humans; D007747:Labor Stage, First / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy
chemical_list: D009125:Muscle Relaxants, Central; D003975:Diazepam