Late-appearing MLL rearrangement arising as a secondary change in adult acute myeloid leukemia.
Rearrangements of MLL are regarded as primary oncogenic events in acute leukemia. We report the case of a patient with acute myeloid leukemia with a complex abnormal karyotype at diagnosis who showed a putative stem line with monosomy 5 and a rearrangement of chromosome 17 as the only abnormalities and an evolved clone with an additional t(7,16,11)(p1?4;p13;q23) after treatment. Fluorescence in situ hybridization analysis confirmed that the translocation had resulted in an MLL rearrangement not present in the stem line or in the complex clones found at diagnosis. To date, this is the first report of an MLL rearrangement evolving as a secondary abnormality within a preexisting leukemic clone.
Rowe
David
D
Institute of Human Genetics, University of Newcastle upon Tyne, England. david.rowe@ncl.ac.uk
Breese
Gareth J
GJ
Lennard
Anne
A
Bown
Nick
N
D000208:Acute Disease; D000328:Adult; D004268:DNA-Binding Proteins / Q000235:genetics*; D015321:Gene Rearrangement / Q000235:genetics*; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D051788:Myeloid-Lymphoid Leukemia Protein; D011519:Proto-Oncogenes; D014157:Transcription Factors
D004268:DNA-Binding Proteins; C497422:KMT2A protein, human; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase