title: Cyanoacrylate tissue adhesive for treatment of refractory corneal ulceration.
abstract: Isobutyl cyanoacrylate tissue adhesive (BCTA) was used in the treatment of refractory superficial corneal ulcers in 17 dogs, one cat, and one rabbit, present 2 weeks to 7 months (mean 6.8 weeks +/- 6.1) prior to referral. Little to no sedation was required in the majority of cases, with only topical anesthetic applied prior to debridement and BCTA application. The presence of the tissue adhesive caused mild discomfort for several days after application, as reported by the owners. The ulcers healed, and the tissue adhesive sloughed in approximately 3 weeks (+/- 1 week). Mild neovascularization of the cornea resolved with topical corticosteroids. The use of BCTA offers a simple, safe and noninvasive treatment for refractory corneal ulcers.
authors.affiliation: Eye Clinic for Animals, VCA/Veterinary Referral Associates, 15021 Dufief Mill Road, Gaithersburg, MD 20878, USA. nbrom@aol.com
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Bromberg
mesh_terms: D000818:Animals; D002015:Bucrylate / Q000627:therapeutic use*; D002371:Cat Diseases / Q000601:surgery*; D002415:Cats; D003316:Corneal Diseases / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000601:surgery*; D004285:Dogs; D011817:Rabbits; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D014014:Tissue Adhesives; D002015:Bucrylate