[Significance of human telomerase RNA expression in situ in malignant melanoma].
By using the method of hybridization in situ, human telomerase RNA(hTR) are detected in 36 cases of malignant melanoma tissue, 16 cases of nevocellular nevus and 12 cases of normal skin. Results showed that the positive expression percentage of hTR in malignant melanoma, nevocellular nevus and normal skin was 86.3%, 6.26% and 12.7%, respectively. The positive expression percentage of hTR in malignant melanoma was significantly higher than that of nevocellular nevus and normal skin(P < 0.01). Meanwhile, the positive expression intensity of hTR in metastatic malignant melanoma is frequently stronger than that of original malignant melanoma(P < 0.05). The results suggest that hTR might indirectly reflect the telomerase activity, and be used as a new marker for diagnosis of malignant melanoma and metastasis prediction.
Wei
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Department of Pathology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Fen
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D000328:Adult; D014408:Biomarkers, Tumor; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008545:Melanoma / Q000201:enzymology*; D008875:Middle Aged; D009506:Nevus / Q000201:enzymology*; D012333:RNA, Messenger / Q000235:genetics; D012878:Skin Neoplasms / Q000201:enzymology*; D019098:Telomerase / Q000096:biosynthesis* / Q000235:genetics
D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D019098:Telomerase