title: Investigation of the larvicidal activity of Pothomorphe peltata and isolation of the active constituent.
abstract: The insecticidal activity of the leaves of Pothomorphe peltata (Piperaceae) was evaluated on Aedes aegypti larvae. The active methanol extract was subjected to a bioactivity-directed fractionation, monitored by the larvicidal assay, and led to the isolation of a catechol derivative, 4-nerolidylcatechol. This compound was quite potent against Aedes aegypti larvae (LC(50) = 9.1 microg/mL).
authors.affiliation: Cátedra de Farmacognosia, IQUIMEFA-CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113) Buenos Aires, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Mongelli
authors.forename: J
authors.initials: J
authors.lastname: Coussio
authors.forename: G
authors.initials: G
authors.lastname: Ciccia
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000818:Animals; D002396:Catechols / Q000494:pharmacology*; D007306:Insecticides / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D026321:Piperaceae; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves
chemical_list: C110583:4-nerolidylcatechol; D002396:Catechols; D007306:Insecticides; D010936:Plant Extracts