Solutol and cremophor products as new additives in suppository formulation.
Our research has a double purpose. On the one hand, doctors have expressed the need to formulate a rectal suppository dosage form from diuretic ethacrynic acid, which would add to the choice of treatment methods and thereby increase the possibilities of individual cure. On the other hand, the liberation and thereby the bioavailability of poorly-soluble ethacrynic acid needs to be enhanced, and for this purpose solubility-increasing additives new to rectal therapy were used. Solutol HS 15, Cremophor RH 40, and Cremophor RH 60 were used as additives in concentrations of 1, 3, 5, and 10%. The quantity of drug released changed as a function of additive concentration. Depending on the acceptor phase, the best results were achieved with an additive concentration of 1-3%, which is related to the optimal additive quantity accumulated on the boundary surface.
Berkó
Szilvia
S
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Szeged, Hungary.
Regdon
Géza
G
Erös
István
I
D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004232:Diuretics / Q000008:administration & dosage*; D004976:Ethacrynic Acid / Q000008:administration & dosage*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012007:Rectum; D013229:Stearic Acids / Q000737:chemistry*; D013488:Suppositories / Q000737:chemistry*
D004232:Diuretics; D013229:Stearic Acids; D013488:Suppositories; C022131:cremophor; D011092:Polyethylene Glycols; C067028:Solutol HS 15; D004976:Ethacrynic Acid