title: Linkage disequilibrium and founder effect analysis of the NF1 gene in French Canadians from the Quebec population.
abstract: We genotyped 19 neurofibromatosis type 1 (NF1) families from French Canadians of the Quebec population with four intragenic microsatellites (IVS26-2.3, IVS27AC28.4, IVS27AC33.1, and IVS38GT53.0). Linkage analysis of the four microsatellite markers among the 19 NF1 families indicates that the four microsatellites are strongly linked with NF1 disease (LOD = 2.76-3.64). The four markers are associated (P = 0-0.077) except marker pair IVS26-2.3/IVS27AC33.1 (P = 0.18 or 0.17). However, perhaps due to the high mutation rate of the NF1 gene, no founder effect for NF1 was detected in the Quebec French Canadians.
authors.affiliation: Département de microbiologie et d'infectiologie, faculté de médecine, Université de Sherbrooke, Sherbrooke, PQ J1H 5N4, Canada.
authors.forename: Li Juan
authors.initials: LJ
authors.lastname: Fang
authors.forename: Wentian
authors.initials: W
authors.lastname: Li
authors.forename: Nader
authors.initials: N
authors.lastname: Chalhoub
authors.forename: Josué
authors.initials: J
authors.lastname: Feingold
authors.forename: June
authors.initials: J
authors.lastname: Ortenberg
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Thirion
mesh_terms: D018703:Founder Effect; D005787:Gene Frequency; D016514:Genes, Neurofibromatosis 1; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D011792:Quebec
chemical_list: D005819:Genetic Markers