title: Role of the area postrema of medulla oblongata in the regulation of canine interdigestive migrating motor complex.
abstract: OBJECTIVE
  To determine the effect of the area postrema (AP) of the medulla oblongata on gastrointestinal interdigestive migrating motor complex (MMC) and the plasma motilin level.
  
  
  METHODS
  Interdigestive MMC activities of the antrum and duodenum were recorded by strain gauge implanted on the serosa of 8 conscious dogs. A cannula was intubated in femoral vein for motilin injection. The plasma motilin concentration was measured by RIA. We observed: (1) normal interdigestive MMC activity and fluctuations in plasma motilin concentration; (2) the effects of electrically damaging the AP on MMC activity and plasma motilin level; (3) whether intravenous injection of motilin could induce phase III contractions after the AP was destroyed.
  
  
  RESULTS
  (1) Typical interdigestive MMC with phase I, II, III, and IV was recorded in normal dogs. Phase III was concurrent with the peak of plasma motilin level. (2) In damaged AP dogs, antroduodenal interdigestive MMC contractions were suppressed; cyclic, phasic and migratory pattern of MMC was disrupted. Plasma motilin concentration was decreased. Intravenous injection of motilin could not induce phase III contractions.
  
  
  CONCLUSIONS
  The area postrema might play an important role, which is mediated by motilin, on the regulation of interdigestive MMC.
authors.affiliation: Department of Physiology, Institute of Basic Medical Science, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union of Medical College, Beijing 100005, China.
authors.forename: Lijian
authors.initials: L
authors.lastname: Wang
authors.forename: Lü
authors.initials: L
authors.lastname: Zhou
authors.forename: Rui
authors.initials: R
authors.lastname: Tian
mesh_terms: D000818:Animals; D004285:Dogs; D020546:Fourth Ventricle / Q000502:physiology*; D008526:Medulla Oblongata / Q000502:physiology*; D009037:Motilin / Q000097:blood*; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D013270:Stomach / Q000502:physiology
chemical_list: D009037:Motilin