In vitro Inhibition of HHV-6 replication by sophocarpines.
The virostatic activity of sophocarpines and gancyclovir (GCV) was tested using HHV-6 Z29 strain and Molt-3 cells. The cytotoxic (IC(50)) and the antiviral (ED(50)) values were first experimentally determined and selective indices (SI) were then calculated. The SI values for sophocarpines 1 and 2 and GCV were in the order 184, 183, and 23, respectively. Though preliminary, these findings indicate that sophocarpines have the potential to inhibit HHV-6 replication.
Qavi
Hamida B
HB
Department of Biochemistry, King Saud University, Riyadh, Saudi Arabia.
Wyde
Philip R
PR
Khan
Mushtaq A
MA
D000470:Alkaloids / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015774:Ganciclovir / Q000494:pharmacology*; D015654:Herpesvirus 6, Human / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D020128:Inhibitory Concentration 50; D010936:Plant Extracts / Q000494:pharmacology; D029909:Sophora; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects; D000093842:Matrines
D000470:Alkaloids; D000998:Antiviral Agents; D015774:Ganciclovir; D010936:Plant Extracts; C035933:sophocarpine; D000093842:Matrines