title: Venous thrombosis associated with peripherally inserted central catheters: a retrospective analysis of the Cleveland Clinic experience.
abstract: Peripherally inserted central catheters (PICCs) have become popular for long courses of intravenously administration of antibiotics. Although these devices are generally regarded as safe, thrombotic complications have been associated with their use. In a retrospective review, 51 (2.47%) of 2063 patients who had a PICC placed during 1994-1996 were found to have developed a total of 52 PICC-associated venous thromboses (VTs). Two patients received the diagnosis of pulmonary embolism that was a complication of VT. Risk factors for VT identified by multiple logistic regression analysis were younger age, history of VT, discharge to a skilled-nursing facility, and therapy with amphotericin B. VT is a significant complication of PICC placement. It may occur more frequently than previously recognized and may be complicated by pulmonary embolism. Clinicians should maintain a high index of suspicion, especially for high-risk patients.
authors.affiliation: Department of Infectious Diseases, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
authors.forename: Roy F
authors.initials: RF
authors.lastname: Chemaly
authors.forename: Joaquin Barbara
authors.initials: JB
authors.lastname: de Parres
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Rehm
authors.forename: Karim A
authors.initials: KA
authors.lastname: Adal
authors.forename: Michelle V
authors.initials: MV
authors.lastname: Lisgaris
authors.forename: Debbie S
authors.initials: DS
authors.lastname: Katz-Scott
authors.forename: Susan
authors.initials: S
authors.lastname: Curtas
authors.forename: Steven M
authors.initials: SM
authors.lastname: Gordon
authors.forename: Ezra
authors.initials: E
authors.lastname: Steiger
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Olin
authors.forename: David L
authors.initials: DL
authors.lastname: Longworth
mesh_terms: D016022:Case-Control Studies; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D005260:Female; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D020246:Venous Thrombosis / Q000209:etiology*