Effects of deltamethrin on lipid peroxidation in mice.
Effects of deltamethrin on lipid peroxidation were investigated for subacute, subchronic and chronic periods. Deltamethrin was given to Swiss Albino mice at 1.5, 2.5, or 7.5 mg/kg. Lipid peroxidation was evaluated by determining malondialdehyde (MDA) levels in plasma, and determining glutathione peroxidase (GSH-Px), superoxide dismutase (Cu-Zn SOD) and catalase activities in erythrocytes on days 15, 45, and 60. MDA levels increased in deltamethrin dosed groups, especially for the subchronic and chronic periods. GSH-Px, Cu-Zn SOD and catalase activities in erythrocytes were decreased at high doses of deltamethrin, especially at the high dose (7.5 mg/kg) deltamethrin group.
Yarsan
Ender
E
Ankara University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Diskapi, Turkey.
Bilgili
Ali
A
Kanbur
Murat
M
Celik
Sefa
S
D000818:Animals; D002374:Catalase / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000494:pharmacology; D007306:Insecticides / Q000009:adverse effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D009570:Nitriles; D011722:Pyrethrins / Q000009:adverse effects*; D013482:Superoxide Dismutase / Q000494:pharmacology
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase