title: Immunoneutralization and anti-idiotype production: two-sided applications of leptin.
abstract: The neuroendocrine and immune systems are linked through a complex bi-directional network, in which hormones modify immune function, and the immune system, through the action of cytokines, affects neuroendocrine responses involved in the maintenance of body homeostasis. The adipocyte-derived, peptide hormone leptin is a pleiotropic molecule belonging to the helical cytokine family. On pp. 182-187, Matarese et al. suggest the possibility of new leptin-based therapeutic strategies for the treatment of both infection and autoimmune disease.
authors.forename: Brant A
authors.initials: BA
authors.lastname: De Fanti
authors.forename: Oscar
authors.initials: O
authors.lastname: Lamas
authors.forename: Fermin I
authors.initials: FI
authors.lastname: Milagro
authors.forename: Eduardo
authors.initials: E
authors.lastname: Martínez-Ansó
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martínez
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis / Q000494:pharmacology* / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D005260:Female; D020738:Leptin / Q000276:immunology* / Q000502:physiology; D008297:Male; D051379:Mice; D009500:Neutralization Tests; D009752:Nutritional Status / Q000502:physiology; D051381:Rats
chemical_list: D000888:Antibodies, Anti-Idiotypic; D020738:Leptin