Asymmetric myoclonic parietal syndrome in a patient with Alzheimer's disease mimicking corticobasal degeneration.
We describe a patient who presented a progressive asymmetrical parietal syndrome including ideomotor apraxia, hemiinattention, unilateral limb dystonia and myoclonus. The clinical picture of this patient supported the clinical diagnosis of corticobasal degeneration (CBD). However, the neuropathologic examination revealed abundant cortical betaA4-amyloid deposits, and phosphorylated tau accumulation in neuritic plaques, neurofibrillary tangles and neuropil threads corresponding to Alzheimer's disease (AD) stage V of Braak and Braak. This case supports the clinical heterogeneity in AD and the existence of a clinical overlap between AD and CBD.
Lleó
A
A
Department de Neurologia. Institut Clinic Malalties Sistema Nerviós. Hospital Clinic de Barcelona. Spain.
Rey
M J
MJ
Castellví
M
M
Ferrer
I
I
Blesa
R
R
D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D003937:Diagnosis, Differential; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000175:diagnosis* / Q000209:etiology*; D019636:Neurodegenerative Diseases / Q000175:diagnosis*; D010296:Parietal Lobe / Q000473:pathology*; D015899:Tomography, Emission-Computed, Single-Photon