[Effects of yanggan xifeng recipe on changes of neurological behavior of rat of Parkinson's model].
OBJECTIVE
To investigate the effect of Yanggan Xifeng Recipe (YGXFR) for nourishing Liver to calm down endogenous Wind on neurological behavior of Parkinson's disease (PD) rat model.


METHODS
PD rat model was established by destroying the substantia nigra condense area (SNc) and ventral tegmental area (VTA) unilaterally with 6-hydroxy dopamine (6-OHDA). The rats for control were injected in the same site with the same dose of normal saline. The animals were randomly divided into 3 groups (7 in each group), the control group, the model group and the TCM treated group. Staircase test and rotation test induced by apomorphine were performed in all groups and compared.


RESULTS
The staircase test demonstrated that, after being treated with YGXFR, the food pellets intake were increased compared to model group (P < 0.05), and their rotation induced by apomorphine was lessened (P < 0.01).


CONCLUSIONS
YGXFR could recover the neurological behavior deficits of PD rat models.
Li
W
W
Huashan Hospital, Shanghai Medical University, Shanghai 200040.
Cai
D
D
Chen
X
X
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D016627:Oxidopamine; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000523:psychology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012399:Rotation
D004365:Drugs, Chinese Herbal; D016627:Oxidopamine