Modification by Chronic Antidepressant Treatment of the Effect of Electroconvulsive Shock on Body Temperature in Mice.
The time course of rectal temperature following a single electroconvulsive shock (ECS) was measured in mice 24 h after a single i.p. administration (10 mg/kg) of desipramine, fluoxetine, amitriptyline, pargyline, or saline, as well as 24 h, 1 week, and 2 weeks after the last of 14 once-daily administrations of these antidepressants. There was a decrease of >2 degrees C following a single ECS lasting for at least 90 min, which was not altered by single-dose antidepressant treatment. Following chronic antidepressant treatment, there was a marked attenuation 24 h after the last dose of all drugs used. There was no attenuation 1 and 2 weeks following chronic treatment. Taken together with earlier studies, ECS affects body temperature similarly to 8-OH-DPAT [8-hydroxy-2-(di-n-propylamino)-tetralin] and clonidine. However, the mechanism is not yet clear.
Gleiter
Christoph H.
CH
Laboratory of Clinical Studies, DICBR, National Institute on Alcoholism and Alcohol Abuse, Bethesda, Maryland, USA.
Wozniak
Krystyna M.
KM
DeJong
Judith
J