title: How should we grade CIN?
abstract: How should we grade CIN? The grading of cervical intraepithelial neoplasia (CIN) is problematic. CIN represents a morphological continuum, but biopsies displaying this lesion are classified into two (e.g. Bethesda) or three grade categories, sometimes with poor reproducibility. There are also difficulties in reliably distinguishing low-grade CIN from its reactive simulants. Because of problems with inter- and intra-observer disagreement in the grading of CIN and the diagnosis of low-grade lesions, three expert contributions were commissioned to address the question 'how should we grade CIN?'.
authors.affiliation: Department of Histopathology, St James's University Hospital, Leeds, UK.
authors.forename: M K
authors.initials: MK
authors.lastname: Heatley
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D012720:Severity of Illness Index; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000145:classification / Q000473:pathology*