CJ-21,058, a new SecA inhibitor isolated from a fungus.
A new equisetin derivative, CJ-21,058 (I) was isolated from the fermentation broth of an unidentified fungus CL47745. It shows antibacterial activity against Gram-positive multi-drug resistant bacteria by inhibiting ATP-dependent translocation of precursor proteins across a bacterial cell membrane.
Sugie
Yutaka
Y
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. Yutaka.Sugie@japan.pfizer.com
Inagaki
Sae
S
Kato
Yoshinao
Y
Nishida
Hiroyuki
H
Pang
Chang-Hong
CH
Saito
Toshiyuki
T
Sakemi
Shinichi
S
Dib-Hajj
Fadia
F
Mueller
John P
JP
Sutcliffe
Joyce
J
Kojima
Yasuhiro
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009281:Naphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011760:Pyrrolidinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013764:Tetrahydronaphthalenes
D000900:Anti-Bacterial Agents; C451492:CJ 21058; D009281:Naphthalenes; D011760:Pyrrolidinones; D013764:Tetrahydronaphthalenes; C024509:equisetin