title: [Effect of selective digestive decontamination on the nosocomial infection and multiresistant microorganisms incidence in critically ill patients].
abstract: BACKGROUND
  Ventilator-associated pneumonia (VAP) is a common complication in mechanically ventilated patients. Other infections related to the use of invasive devices, such urinary tract infections (UTI) and central venous catheter-related bloodstream infections are found in patients admitted in intensive care units (ICU). Selective digestive decontamination (SDD) is a set of manoeuvres (hygiene, topic digestive antimicrobials and short course of systemic antibiotics) aimed at decreasing the incidence of nosocomial infections, mainly VAP, in ICU. The objective of this study was to describe the impact of SDD in the rates of nosocomial infections in an 18-bed medical-surgical ICU.
  
  
  METHODS
  All patients admitted in the ICU from October 1998 to September 1999 with expected mechanical ventilation for at least 72 h or with an illness where SDD has proven to be efficacious. The infection rates during this period were compared with the infection rates of the period without SDD (October 1997 to September 1998).
  
  
  RESULTS
  VAP rates decreased from 12.38 to 3.64 per 1000 days of mechanical ventilation (RR 0.3; CI 95%: 0.16 to 0.53). Urinary tract infection rates decreased form 7.70 to 4.51 per 1000 bladder-catheter days (RR 0.6. CI 95%: 0.37 to 0.93). Central venous catheter related bloodstream infections decreased from 5.92 to 2.73 per 1000 catheter days (RR: 0.5. CI 95%: 0.24 to 0.90). There was no emergence of resistant microorganims when SDD was used.
  
  
  CONCLUSIONS
  SDD reduces infection rates in ICU without any significant adverse events.
authors.affiliation: Servicio de Cuidados Intensivos/Grandes Quemados, Hospital Universitario de Getafe, Madrid, Spain.
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Parra Moreno
authors.forename: Susana
authors.initials: S
authors.lastname: Arias Rivera
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: de la Cal López
authors.forename: Fernando
authors.initials: F
authors.lastname: Frutos Vivar
authors.forename: Enrique
authors.initials: E
authors.lastname: Cerdá Cerdá
authors.forename: Paloma
authors.initials: P
authors.lastname: García Hierro
authors.forename: Eva
authors.initials: E
authors.lastname: Negro Vega
mesh_terms: D003428:Cross Infection / Q000453:epidemiology* / Q000517:prevention & control*; D003666:Decontamination / Q000379:methods*; D004064:Digestive System; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000453:epidemiology* / Q000517:prevention & control*; D011446:Prospective Studies; D012122:Ventilators, Mechanical / Q000009:adverse effects*
vernacular_title: Descontaminación selectiva del tubo digestivo: efecto sobre la incidencia de la infección nosocomial y de los microorganismos multirresistentes en enfermos ingresados en unidades de cuidados intensivos.