[Celecoxib induced toxiderma with positive patch-test].
BACKGROUND
Celecoxib (Celebrex(R)) is a new generation non-steroidal anti-inflammatory drug, recently introduced in France. We report a maculopapular rash due to this drug with positive patch-tests.


METHODS
A forty year-old man received with 3 tablets/day of celecoxib for intercostal pain. Nine days after initiation of treatment a maculopapular rash appeared. At the end of treatment, the eruption persisted for two days, then rapidly improved within one week. Six weeks later, patch-tests with celecoxib diluted at 20 p. 100 in petrolatum were positive at 48 hours.


CONCLUSIONS
Cutaneous reactions due to celecoxib are rare. In our case report, the delay, clinical aspect, improvement on withdrawal of treatment and positive patch test all emphasize the imputability of celecoxib. We wish to underline the possible cutaneous reactions with this new non-steroidal anti-inflammatory drug.
Verbeiren
S
S
Service de Dermatologie, Centre Hospitalier Saint-Philibert, Université Catholique de Lille, 115, rue du Grand But, BP 249, 59462 Lille.
Morant
C
C
Charlanne
H
H
Ajebbar
K
K
Caron
J
J
Modiano
P
P
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D000068579:Celecoxib; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D011720:Pyrazoles; D012882:Skin Tests; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*; D013607:Tablets; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013449:Sulfonamides; D013607:Tablets; D000068579:Celecoxib
Toxidermie au célécoxib (Cerebrex(R)) avec test épicutané positif.