[Ocular involvement during primary central nervous system lymphoma].
OBJECTIVE
The aim of our study was to assess and to characterize the ocular involvement in patients with primary central nervous system lymphoma.


METHODS
We conducted a prospective study between August 1995 and December 1998 on a cohort of consecutive patients affected by primary central nervous system lymphoma and who underwent a systematic ophthalmological examination before treatment.


RESULTS
The study population comprised 24 patients (mean age, 57 years; 16 women and 8 men). Among these patients, 6 had ocular involvement (2 patients with ocular signs revealing the cerebral process, 2 evidenced at the time of the initial ocular examination, and 1 as the disease evolved). Ocular involvement was vitritis in all cases, anterior uveitis in 1 patient, obliterant vasculitis in 1 patient and yellowish subretinal lesions in 1 patient. In 1 case, a vitrectomy led to adequate diagnosis of the disease.


CONCLUSIONS
Our study shows a 25% incidence of ocular involvement in patients with primary central nervous system lymphoma, with posterior uveitis as the most common manifestation. Because of the relatively high incidence of ocular involvement, a systematic ophthalmological examination of this subset of patients should be mandatory.
Angioi-Duprez
K
K
Service d'Ophtalmologie B, CHU de Nancy-Brabois, rue du Morvan, 54511 Vandoeuvre Cedex.
Taillandier
L
L
Gérin
M
M
Berrod
J P
JP
George
J L
JL
Maalouf
T
T
D000328:Adult; D000368:Aged; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000532:radiotherapy / Q000628:therapy; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000175:diagnosis / Q000532:radiotherapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000532:radiotherapy / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D013997:Time Factors; D015866:Uveitis, Posterior / Q000209:etiology; D014821:Vitrectomy
L'atteinte oculaire au cours des lymphomes primitifs du système nerveux central.