title: Osteoradionecrosis of the mandible: scientific basis for clinical staging.
abstract: Osteoradionecrosis of the mandible can be a serious complication of radiotherapy for head and neck cancer. The disorder generally presents in one of several distinct clinical variations. This is probably because of a complex interaction of etiologic factors. A clinical staging system for the disorder is described. Such a system is necessary for the conduct of clinical research, and for the development and assessment of treatment regimens.
authors.affiliation: Department of Maxillofacial Surgery, Southern California Permanente Medical Group, Los Angeles, California, USA.
authors.forename: Harry C
authors.initials: HC
authors.lastname: Schwartz
authors.forename: A Robert
authors.initials: AR
authors.lastname: Kagan
mesh_terms: D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D008336:Mandibular Diseases / Q000473:pathology*; D010025:Osteoradionecrosis / Q000145:classification / Q000473:pathology*; D011878:Radiotherapy / Q000009:adverse effects