title: Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult.
abstract: Serotonin is implicated in mood regulation, and drugs acting via the serotonergic system are effective in treating anxiety and depression. Specifically, agonists of the serotonin1A receptor have anxiolytic properties, and knockout mice lacking this receptor show increased anxiety-like behaviour. Here we use a tissue-specific, conditional rescue strategy to show that expression of the serotonin1A receptor primarily in the hippocampus and cortex, but not in the raphe nuclei, is sufficient to rescue the behavioural phenotype of the knockout mice. Furthermore, using the conditional nature of these transgenic mice, we suggest that receptor expression during the early postnatal period, but not in the adult, is necessary for this behavioural rescue. These findings show that postnatal developmental processes help to establish adult anxiety-like behaviour. In addition, the normal role of the serotonin1A receptor during development may be different from its function when this receptor is activated by therapeutic intervention in adulthood.
authors.affiliation: Center for Neurobiology and Behavior, Columbia University, New York 10032, USA.
authors.forename: Cornelius
authors.initials: C
authors.lastname: Gross
authors.forename: Xiaoxi
authors.initials: X
authors.lastname: Zhuang
authors.forename: Kimberly
authors.initials: K
authors.lastname: Stark
authors.forename: Sylvie
authors.initials: S
authors.lastname: Ramboz
authors.forename: Ronald
authors.initials: R
authors.lastname: Oosting
authors.forename: Lynn
authors.initials: L
authors.lastname: Kirby
authors.forename: Luca
authors.initials: L
authors.lastname: Santarelli
authors.forename: Sheryl
authors.initials: S
authors.lastname: Beck
authors.forename: René
authors.initials: R
authors.lastname: Hen
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001007:Anxiety / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D018345:Mice, Knockout; D010641:Phenotype; D016548:Prosencephalon / Q000378:metabolism / Q000502:physiology; D011985:Receptors, Serotonin / Q000235:genetics / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
chemical_list: D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists