[Follow-up study of human herpesvirus 6 and human cytomegalovirus infection in organ transplantation recipients].
OBJECTIVE
To trace the study of the prevalence and adverse factors of human herpesvirus 6(HHV-6) and human cytomegalovirus(HCMV) infection in organ transplantation recipients.


METHODS
Blood and urine specimens were detected by virus isolation, polymerase chain reaction(PCR), and indirect immunofluorescent assay.


RESULTS
HCMV and HHV-6 isolation rate were 25.8% and 32.3%, respectively. Anti-HCMV IgM and anti-HHV-6 IgM positive rates before operation were 0% and 3.2%, their positive rates after operation were 19.4% and 25.8%, respectively. HCMV-DNA and HHV-6-DNA positive rates before operation were 35.5% and 45.2%; their positive rates after operation were 45.2% and 61.3%, and kept the high positive rates for a long period. The patients who died within 3 months were all complicated by HCMV and/or HHV-6 productive infection. The productive infection rates of HCMV and HHV-6 were 25.8% and 32.2%, respectively.


CONCLUSIONS
The majority of HCMV and HHV-6 infection are reactivation. Productive infection attack at 2 weeks after operation, reaches the peak at 3-4 weeks after operation, and attacks at anytime within 3 months. HCMV and/or HHV-6 productive infection are fatal to recipients.
Luo
M
M
Department of Microbiology and Immunology, Hunan Medical University, Changsha 410078.
Xiao
Y
Y
Dai
G
G
D003586:Cytomegalovirus Infections; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006566:Herpesviridae Infections; D015654:Herpesvirus 6, Human; D006801:Humans; D016031:Liver Transplantation; D016040:Lung Transplantation; D008297:Male; D016377:Organ Transplantation; D011183:Postoperative Complications / Q000821:virology*