Concomitant tetrasomy 3q and trisomy 18 in CD5(-), CD13(+) chronic lymphocytic leukemia.
Chronic lymphocytic leukemia (CLL) associated with myeloid antigens on the surface of B neoplastic cells is a recently identified immunologic variant confined to patients with CD5 negative B-CLL. We describe the case of a 61-year-old female diagnosed with CD5(-), CD13(+) B-CLL with a tetrasomy 3q revealed by fluorescence in situ hybridization analysis, in addition to trisomy 18. To our knowledge, this is the first reported case of B-CLL with this kind of cytogenetic abnormality.
Specchia
Giorgina
G
Department of Hematology, University of Bari, Policlinico, 70124 Bari, Italy. emadhba@cimedoc.uniba.it
Albano
Francesco
F
Anelli
Luisa
L
Storlazzi
Clelia Tiziana
CT
Monaco
Michele
M
Capalbo
Silvana
S
Rocchi
Mariano
M
Liso
Vincenzo
V
D018826:CD13 Antigens / Q000378:metabolism*; D018956:CD5 Antigens / Q000378:metabolism*; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D014314:Trisomy
D018956:CD5 Antigens; D018826:CD13 Antigens