[The synthesis and immunosuppressive effects of steroid-peptide linkers].
Hydrocortisone was coupled with urotoxin tripeptide UTP-A, UTP-B and UTP-C respectively yielding 4 linkers. Their bioactivities such as prolongation of heterotopic transplanted cardiac tissue survival, inhibitory effects on phagocytosis of mouse peritoneal macrophages and the influence on Con A induced proliferation of spleen lymphocytes of mouse were observed. Compared with UTP-A, UTP-B, UTP-C or hydrocortisone the linkers were more potent immunosuppressants. The results suggest that the linker of steroid-peptide may simulate the permissive action.
Wang
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C
College of Phamacutical Sciences, Beijing Medical University, Beijing 100083.
Peng
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S
Zhang
X
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Qiu
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X
D000818:Animals; D005260:Female; D016027:Heart Transplantation; D006835:Hydrazones / Q000138:chemical synthesis*; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009842:Oligopeptides; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology; D013256:Steroids / Q000138:chemical synthesis* / Q000494:pharmacology
D006835:Hydrazones; D007166:Immunosuppressive Agents; D009842:Oligopeptides; D010455:Peptides; D013256:Steroids; D006854:Hydrocortisone