title: Inherited factor VII deficiency and surgery: clinical data are the best criteria to predict the risk of bleeding.
abstract: Inherited factor VII (FVII) deficiency is a rare autosomal disorder characterized by a weak relationship between FVII activity (FVII:C) and operative bleeding risk. We report a retrospective study of 17 patients with a FVII:C below 0.1 IU/ml, in whom surgery was performed without any replacement therapy. Clinical and biological data were analysed to establish predictive criteria for bleeding tendency. We found that systematic preoperative replacement therapy may not be necessary for 'minor' surgical procedures, for patients suffering from inherited FVII deficiency, unless the clinical history includes severe haemorrhagic symptoms such as haemarthrosis, severe haematomas (even of soft tissue) or abundant epistaxis.
authors.affiliation: Laboratory of Haematology, University Hospital, Montpellier, France. m-giansily@chu-montpellier.fr
authors.forename: Muriel
authors.initials: M
authors.lastname: Giansily-Blaizot
authors.forename: Christine
authors.initials: C
authors.lastname: Biron-Andreani
authors.forename: Patricia
authors.initials: P
authors.lastname: Aguilar-Martinez
authors.forename: Philippe
authors.initials: P
authors.lastname: de Moeloose
authors.forename: Marie-Elisabeth
authors.initials: ME
authors.lastname: Briquel
authors.forename: Jenny
authors.initials: J
authors.lastname: Goudemand
authors.forename: Nathalie
authors.initials: N
authors.lastname: Stieltjes
authors.forename: Claire
authors.initials: C
authors.lastname: Barrot
authors.forename: Herve
authors.initials: H
authors.lastname: Chambost
authors.forename: Anne
authors.initials: A
authors.lastname: Durin
authors.forename: Valerie
authors.initials: V
authors.lastname: Gay
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Peynet
authors.forename: Katia
authors.initials: K
authors.lastname: Pouymayou
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Schved
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D002648:Child; D005168:Factor VII Deficiency / Q000601:surgery*; D005260:Female; D020022:Genetic Predisposition to Disease; D006470:Hemorrhage / Q000235:genetics*; D006488:Hemostasis, Surgical; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors