Epigenetics of dominance for enzyme activity.
We have isolated and purified two parental homodimers and a unique heterodimer of acid phosphatase [coded by Acph-1 (1.05)(F) and Acph-1 (0.95)(S)] from isogenic homozygotes and heterozygotes of Drosophila malerkotliana. F and S produce qualitatively different allozymes and the two alleles are expressed equally within and across all three genotypes and F and S play an equal role in the epigenetics of dominance. Subunit interaction in the heterodimer over a wide range of H+ concentrations accounts for the epigenetics of dominance for enzyme activity.
Trehan
Kuldip S
KS
Department of Genetics, Punjab Agricultural University, Ludhiana 141 004, India. kulvin_78@rediffmail.com
Gill
Kulbir S
KS
D000135:Acid Phosphatase / Q000235:genetics* / Q000378:metabolism; D000483:Alleles; D000818:Animals; D019281:Dimerization; D004330:Drosophila / Q000201:enzymology* / Q000235:genetics*; D005799:Genes, Dominant; D017344:Genes, Insect; D005838:Genotype; D006863:Hydrogen-Ion Concentration; D007527:Isoenzymes / Q000235:genetics* / Q000378:metabolism
D007527:Isoenzymes; D000135:Acid Phosphatase