Sequential MRI in a case of Creutzfeldt-Jakob disease.
A 48-year-old man suddenly developed clinically and electroencephalographically nonspecific dementia. On MRI sequences, only diffusion-weighted images (DWI) of the cortex were unequivocally pathological. Obvious atrophy and basal ganglia signal changes appeared only 9 months after the onset. Brain biopsy confirmed Creutzfeldt-Jakob disease (CJD). In rapidly progressive dementia, we recommend DWI for early diagnosis of CJD.
Tribl
G G
GG
Universitätsklinik für Neurologie, Allgemeines Krankenhaus Wien, Währinger Gürtel, Vienna, Austria. Gotthard.Trivl@akh-wien.ac.at
Strasser
G
G
Zeitlhofer
J
J
Asenbaum
S
S
Jarius
C
C
Wessely
P
P
Prayer
D
D
D001921:Brain / Q000473:pathology*; D003287:Contrast Media; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D004569:Electroencephalography; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D003287:Contrast Media; D019786:Gadolinium DTPA