Protective effect of interleukin-4 -589T polymorphism on human immunodeficiency virus type 1 disease progression: relationship with virus load.
The interleukin (IL)-4 -589T allele bears a single nucleotide polymorphism at position -589 upstream from the open-reading frame of the IL-4 gene. To determine the influence of this allele on human immunodeficiency virus (HIV) type 1 disease, disease progression and serum virus load were assessed by IL-4 genotype in 427 white patients with known seroconversion dates who were followed in the French SEROCO cohort between 1988 and 1996. Serum virus load was 0.20 log lower during the 6-24-month plateau phase after seroconversion in patients with IL-4 -589T than in those without this allele (P=.02). Kaplan-Meier analysis survival curves showed a slower progression to clinical AIDS in carriers of IL-4 -589T (P=.04). Adjustment for early serum virus load greatly diminished the strength of this association. These results suggest that IL-4 -589T protects against HIV-1 disease progression by reducing virus load.
Nakayama
Emi E
EE
Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita-shi, Osaka 565-0871, Japan.
Meyer
Laurence
L
Iwamoto
Aikichi
A
Persoz
Anne
A
Nagai
Yoshiyuki
Y
Rouzioux
Christine
C
Delfraissy
Jean-François
JF
Debre
Patrice
P
McIlroy
Dorian
D
Theodorou
Ioannis
I
Shioda
Tatsuo
T
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000821:virology; D000328:Adult; D005260:Female; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D054390:Receptors, CCR2; D019707:Receptors, Chemokine / Q000235:genetics; D019562:Viral Load
C515334:CCR2 protein, human; D054390:Receptors, CCR2; D019707:Receptors, Chemokine; D015847:Interleukin-4