[A prospective study on the effects of low-osmolar and nonionic contrast media on renal functions].
OBJECTIVE
To investigate the effects of contrast medium, especially large dose of Iopromide, on renal functions.


METHODS
100 hospitalized patients who were going to have cardiac or renal angiography were selected. 96 patients had normal renal functions and 4 had slightly abnormal renal functions. Scr, Ccr, urine gamma-GT and urine glucose were monitored on the first, third and fifth day after angiography.


RESULTS
All the 100 patients were administered with Iopromide. Of the 96 patients with normal renal functions, all had elevated urine gamma-GT on the first day after giving Iopromide; the level returned to normal on the third day. There was no significant change of Scr and Ccr after angiography. Of the 4 patients with abnormal renal functions, all had significant change of Scr and Ccr after using Iopromide and the levels of both returned to pre-angiography level on the fifth day.


CONCLUSIONS
In patients with normal renal functions, Iopromide may cause transient elevation of urine gamma-GT level and positive urine glucose. In patients with slightly abnormal renal functions, Iopromide may cause significant decrease of Ccr and increase of Scr. However, with proper treatment, these indexes may return to pre-angiography level on the fifth day after angiography.
Liu
Y
Y
Institute of Nephrology, First Hospital, Peking University, Beijing 100034, China.
Yang
F
F
Hu
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007472:Iohexol / Q000009:adverse effects* / Q000031:analogs & derivatives*; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D008875:Middle Aged; D011446:Prospective Studies; D020127:Recovery of Function / Q000502:physiology; D005723:gamma-Glutamyltransferase
D003287:Contrast Media; D007472:Iohexol; C038192:iopromide; D003404:Creatinine; D005723:gamma-Glutamyltransferase