[Affect of insulin-like growth factor I and estradiol on the growth of uterine leiomyoma].
To study roles of insulun-like growth factor 1(IGF-I) and estradiol(E2) in the growth of leiomyoma. Protein expressions of IGF-I receptor(IGF-I-R), estrogen receptor(ER), and cell proliferation associated nuclear antigen(ki-67) were analysed by streptavidin-peroxide method in 40 cases. Serum level and local concentration of IGF-I were determined by immunoradiometric assay(IRMA) in 20 cases. Serum level of estradiol was determined by radioimmunoassay in 20 cases. Twenty normal fertile women were studied as control. Protein expressions of IGF-I-R and ER in uterine leiomyoma were significantly higher than in myometrium(P < 0.05); and local concentration of IGF-I positively correlated with ki-67 (r = 0.6513, P < 0.05); and expression of estrogen receptor. The serum levels of IGF-I and E2 had no significant difference between leiomyoma patients and normal women. IGF-I and E2 promote the growth of leiomyoma and IGF-I may act as a mediator of estrogen.
Huang
J
J
Department of Gynecology and Obstetrics, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Zou
J
J
Xu
B
B
Zhang
Y
Y
Chen
X
X
Liu
D
D
D000328:Adult; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007889:Leiomyoma / Q000378:metabolism* / Q000473:pathology; D011897:Random Allocation; D017526:Receptor, IGF Type 1 / Q000378:metabolism; D011959:Receptors, Estradiol / Q000378:metabolism; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000473:pathology
D011959:Receptors, Estradiol; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1