title: [Dipeptidyl(amino)peptidase IV in the differential diagnosis of thyroid gland tumors: methods and results of a pilot study of 200 cases].
abstract: The use of dipeptidyl aminopeptidase IV (DPP IV) staining by azo-coupling in preoperative and intraoperative diagnostics of thyroid lesions is presented. In a series of 200 histologically confirmed cases examined, the sensitivity and the specificity were 71% and 99%, respectively in 124 smears, and 70% and 94%, respectively in 189 frozen sections. DPP IV expression showed high negative predictive value as well. DPP IV is suggested as an additional tool in the preoperative and intraoperative diagnostics of thyroid lesions.
authors.affiliation: Fingerlandův ústav patologie a II. interní klinika Lékarské fakulty UK a FN, Hradec Králové.
authors.forename: I
authors.initials: I
authors.lastname: Kholová
authors.forename: M
authors.initials: M
authors.lastname: Ludvíková
authors.forename: A
authors.initials: A
authors.lastname: Ryska
authors.forename: J
authors.initials: J
authors.lastname: Cáp
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D003937:Diagnosis, Differential; D018819:Dipeptidyl Peptidase 4 / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D018819:Dipeptidyl Peptidase 4
vernacular_title: Dipeptidyl(amino)peptidáza IV v diferenciální diagnostice nádorů stítné zlázy: popis metodiky a výsledky pilotní studie 200 prípadů.