title: Clinical, endoscopic, and functional studies in 408 patients with Barrett's esophagus, compared to 174 cases of intestinal metaplasia of the cardia.
abstract: OBJECTIVE
  The pathophysiology of gastroesophageal reflux disease (GERD) has been studied extensively in patients with long-segment Barrett's esophagus (LSBE), but few reports have explored GERD pathophysiology in patients who have short-segment Barrett's esophagus (SSBE) or intestinal metaplasia at the cardia (IMC). We aimed to compare clinical, endoscopic, histological, and functional features in patients with LSBE, SSBE, and IMC.
  
  
  METHODS
  We identified 582 patients who had intestinal metaplasia at the squamocolumnar junction in the distal esophagus and divided them into three groups based on the extent of columnar-lined esophagus observed endoscopically: 1) patients with IMC who had no columnar-lined esophagus (i.e., the squamocolumnar and gastroesophageal junctions coincided), 2) patients with LSBE who had >3 cm of columnar-lined esophagus, and 3) patients with SSBE who had <3 cm of columnar-lined esophagus. All patients had esophageal manometric evaluation, and 24-h esophageal pH monitoring was performed to determine the extent of acid and bile (bilirubin) reflux.
  
  
  RESULTS
  There were 174 patients with IMC, 155 with LSBE, and 25 with SSBE. Compared to patients with LSBE and SSBE, patients with IMC had significantly lower frequencies of GERD symptoms, hiatal hernia, and erosive esophagitis; significantly higher lower esophageal sphincter pressures; and significantly shorter durations of acid and bile reflux. Between patients with SSBE and LSBE, significant differences were found in the frequency of hiatal hernia and duration of acid reflux (both greater in the patients with LSBE). Also, dysplasia was significantly more frequent in patients with LSBE than in those with SSBE or IMC.
  
  
  CONCLUSIONS
  GERD symptoms, signs, and physiological abnormalities are found more often in patients with Barrett's esophagus than in those with IMC, and the duration of acid reflux in patients with LSBE is greater than that in patients with SSBE. These findings suggest that the extent of intestinal metaplasia in the esophagus is related directly to the severity of underlying GERD.
authors.affiliation: Department of Surgery and Pathology, University Hospital, Santiago, Chile.
authors.forename: Attila
authors.initials: A
authors.lastname: Csendes
authors.forename: Gladys
authors.initials: G
authors.lastname: Smok
authors.forename: Juan
authors.initials: J
authors.lastname: Quiroz
authors.forename: Patricio
authors.initials: P
authors.lastname: Burdiles
authors.forename: Jorge
authors.initials: J
authors.lastname: Rojas
authors.forename: César
authors.initials: C
authors.lastname: Castro
authors.forename: Ana
authors.initials: A
authors.lastname: Henríquez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D002299:Cardia / Q000473:pathology* / Q000503:physiopathology*; D016145:Endoscopy, Digestive System; D004947:Esophagus / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005750:Gastric Juice / Q000502:physiology; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008679:Metaplasia / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D013272:Stomach Diseases / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*