[Mechanisms of fever].
Fever represents a normal and adaptative response developed in case of host aggression, notably by infectious agents, and is part of a large defense system, the acute phase response. Fever mediators are mainly derived from the host cells and are pyrogenous cytokines such as interleukin-1, tumour necrosis factor alpha, interleukin-6 or interferons which act at the hypothalamus level via prostaglandin E2. Although fever has been conserved through evolution, its beneficial effects in humans are not well-established.
Kaplanski
Gilles
G
Service de médecine Interne Hôpital de la Conception 13385 Marseille. gkaplanski@marseille.inserm.fr
Marin
Valérie
V
D000208:Acute Disease; D000222:Adaptation, Physiological; D016207:Cytokines / Q000494:pharmacology*; D005334:Fever / Q000503:physiopathology*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D007239:Infections / Q000473:pathology*
D016207:Cytokines
Mécanismes de la fièvre.