title: Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities.
abstract: Eight secondary metabolites were isolated from submerged cultures of the ascomycete A111-95 during a search for new nematicidal metabolites. (-)-Galiellalactone (7) and compound 2 are metabolites previously obtained from cultures of Galiella rufa while the compounds 1, 3, 4, 5, 6 and 8 (3 and 4 were obtained as an unseparable mixture), were isolated as natural products for the first time. Compound 2, pregaliellalactone (5) and the mixture of 3 and 4 showed nematicidal activities towards Caenorhabditis elegans and Meloidogyne incognita. All compounds showed moderate or weak cytotoxic activities.
authors.affiliation: Institute of Biotechnology and Drug Research (IBWF), Kaiserslautern, Germany.
authors.forename: Bärbel
authors.initials: B
authors.lastname: Köpcke
authors.forename: Martin
authors.initials: M
authors.lastname: Johansson
authors.forename: Olov
authors.initials: O
authors.lastname: Sterner
authors.forename: Heidrun
authors.initials: H
authors.lastname: Anke
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D001203:Ascomycota; D017173:Caenorhabditis elegans / Q000187:drug effects; D005285:Fermentation; D007928:Lethal Dose 50; D013329:Structure-Activity Relationship; D014431:Tylenchoidea / Q000187:drug effects
chemical_list: D000969:Antinematodal Agents