title: Polysaccharides as excipients for colon-specific coatings. Permeability and swelling properties of casted films.
abstract: Oligosaccharides such as inulin (In) and polysaccharides such as galactomannans, combined with polymethacrylates on isolated films for film coatings, were obtained from aqueous-based solvents and investigated as potential vehicles for colonic drug delivery. These compositions, which are susceptible to fermentation by colonic microflora, constitute promising excipients for the development of new colon-specific therapeutic systems. The characteristics of several compositions have been demonstrated in permeability and swelling studies on isolated films composed of a polymethacrylate associated with In or galactomannans of mesquite seed gum (MSG). Results reported prove a dependency of the properties of mixed films on the polymethacrylate-polysaccharide concentration ratio and on the composition of the dissolution media. An increase in permeability through the mixed films was observed in a simulated colonic environment for the following compositions: Eudragit RS30D-MSG 70:30 w/w; Eudragit RS30D-In 90:10 w/w; Eudragit RS30D-In 76:24 w/w.
authors.affiliation: Pharmacy and Pharmacology Department, Universidade Estadual de Maringá/PR, Brazil. oacavalcanti@uem.br
authors.forename: Osvaldo Albuquerque
authors.initials: OA
authors.lastname: Cavalcanti
authors.forename: Guy
authors.initials: G
authors.lastname: Van den Mooter
authors.forename: Ida
authors.initials: I
authors.lastname: Caramico-Soares
authors.forename: Renaat
authors.initials: R
authors.lastname: Kinget
mesh_terms: D002626:Chemistry, Pharmaceutical; D003106:Colon / Q000187:drug effects; D003108:Colonic Diseases / Q000188:drug therapy*; D005079:Excipients / Q000737:chemistry*; D005285:Fermentation; D006801:Humans; D010539:Permeability; D011109:Polymethacrylic Acids / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*
chemical_list: D005079:Excipients; D011109:Polymethacrylic Acids; D011134:Polysaccharides; C030613:polymethacrylic acid