title: The level of 8-oxo-7,8-dihydro-2'-deoxyguanosine is positively correlated with the size of the labile iron pool in human lymphocytes.
abstract: It appears that the labile iron pool (LIP, low molecular weight iron) presence in cells can result in the production of reactive oxygen species (ROS). ROS may be responsible for the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) in cellular DNA. In the present study we report on the relationship between LIP and the endogenous level of 8-oxodGuo in human lymphocytes. Good correlation has been determined between LIP and the oxidatively modified nucleoside. This in turn points out the possibility that under physiological condition there is the availability of LIP for catalyzing Fenton-type reactions in close proximity to cellular DNA. Electronic supplementary material to this paper can be obtained by using the Springer Link server located at http://dx.doi.org/10.1007/s00775-001-0335-x.
authors.affiliation: Department of Clinical Biochemistry, The Ludwik Rydygier Medical University in Bydgoszcz, ul. Karlowicza 24, 85-092 Bydgoszcz, Poland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gackowski
authors.forename: Marcin
authors.initials: M
authors.lastname: Kruszewski
authors.forename: Teresa
authors.initials: T
authors.lastname: Bartlomiejczyk
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Jawien
authors.forename: Marek
authors.initials: M
authors.lastname: Ciecierski
authors.forename: Ryszard
authors.initials: R
authors.lastname: Olinski
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001205:Ascorbic Acid / Q000097:blood; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood*; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood*; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D000080242:8-Hydroxy-2'-Deoxyguanosine; D007501:Iron; D003849:Deoxyguanosine; D001205:Ascorbic Acid