title: The relation between adrenal function and the severity of bronchial hyperresponsiveness in children as measured by the methacholine provocation test.
abstract: BACKGROUND
  There is no satisfactory explanation why some individuals experience severe attacks of asthma, yet others, exposed to similar stimuli, have a milder form of the disease.
  
  
  OBJECTIVE
  We tested the hypothesis that children with more severe disease may have relative adrenal insufficiency compared to the children with milder disease.
  
  
  METHODS
  Sixteen children with chronic asthma aged 8-16 years old were studied. Adrenal function was evaluated by the 24-h excretion of urinary free cortisol (UFC) before and after ACTH stimulation, and by plasma cortisol levels before and 60 min after ACTH administration. The severity of bronchial hyperresponsiveness was evaluated by the methacholine provocation test.
  
  
  RESULTS
  Nine children had 20% fall in forced expiratory volume in 1 sec (FEV1) after a provocative concentration (PC20FEV1) of methacholine > or =2.5 mg/ml and were considered as having mild-moderate bronchial hyperresponsiveness (Group A). Seven children had a PC20FEV1 of < or =1.25 mg/ml and were considered as having severe bronchial hyperresponsiveness (Group B). No significant difference was found between the peak plasma cortisol response to ACTH between the two groups (634+/-182 and 586+/-137 nmol/l, respectively). However, there was a significant statistical difference (p <0.01) in the 24-h UFC response to ACTH between the children from Group A (345+/-107 nmol/m2 ) and the children from Group B (161+/-125 nmol/m2).
  
  
  CONCLUSIONS
  Based on the low levels of 24-h UFC secretion in severely asthmatic children in our study, we propose the encouragement of provision of a short course of inhaled steroids to be kept at home for the emergency therapy of those children identified as having high-risk asthma.
authors.affiliation: Department of Pediatrics, Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Barr
authors.forename: M J
authors.initials: MJ
authors.lastname: Rapoport
authors.forename: T
authors.initials: T
authors.lastname: Tauber
authors.forename: I
authors.initials: I
authors.lastname: Hertzianu
authors.forename: Y
authors.initials: Y
authors.lastname: Cafri
authors.forename: T
authors.initials: T
authors.lastname: Bistritzer
mesh_terms: D000293:Adolescent; D000304:Adrenal Cortex Function Tests; D000305:Adrenal Cortex Hormones / Q000097:blood / Q000652:urine; D000311:Adrenal Glands / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000652:urine; D001249:Asthma / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D016085:Bronchoconstrictor Agents; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D016210:Methacholine Chloride
chemical_list: D000305:Adrenal Cortex Hormones; D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone