Multiplicity of mechanisms of serotonin receptor signal transduction.
The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those subfamilies have been characterized by overlapping pharmacological properties, amino acid sequences, gene organization, and second messenger coupling pathways. Post-genomic modifications, such as alternative mRNA splicing or mRNA editing, creates at least 20 more G-protein-coupled 5-HT receptors, such that there are at least 30 distinct 5-HT receptors that signal through G-proteins. This review will focus on what is known about the signaling linkages of the G-protein-linked 5-HT receptors, and will highlight some fascinating new insights into 5-HT receptor signaling.
Raymond
J R
JR
The Research Service of the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29401, USA. raymondj@musc.edu
Mukhin
Y V
YV
Gelasco
A
A
Turner
J
J
Collinsworth
G
G
Gettys
T W
TW
Grewal
J S
JS
Garnovskaya
M N
MN
D000262:Adenylyl Cyclases / Q000096:biosynthesis / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D011494:Protein Kinases / Q000096:biosynthesis / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D010738:Type C Phospholipases / Q000096:biosynthesis / Q000494:pharmacology
D007473:Ion Channels; D011985:Receptors, Serotonin; D000242:Cyclic AMP; D011494:Protein Kinases; D010738:Type C Phospholipases; D000262:Adenylyl Cyclases