title: Nervous system pathology: the fibrin perspective.
abstract: Studies of extracellular matrix (ECM) biology in the nervous system have mainly focused on laminin, fibronectin and tenascin-R, proteins that are present during nervous system development and normal function. However, during disease, fibrin, which physiologically is not present in the nervous tissue, is detected at nervous tissue lesions. This review summarizes evidence that correlates fibrin deposition with neuropathology and presents recent findings on cellular mechanisms and intracellular signaling pathways regulated by fibrin that might contribute to nervous system disease.
authors.affiliation: Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10021, USA.
authors.forename: Katerina
authors.initials: K
authors.lastname: Akassoglou
authors.forename: Sidney
authors.initials: S
authors.lastname: Strickland
mesh_terms: D000818:Animals; D005337:Fibrin / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000473:pathology; D009420:Nervous System / Q000473:pathology*; D009422:Nervous System Diseases / Q000209:etiology* / Q000473:pathology; D015398:Signal Transduction
chemical_list: D005337:Fibrin