title: Decreased thyroid uptake of Tc-99m pertechnetate in patients with advanced-stage Sjögren syndrome: evaluation using salivary gland scintigraphy.
abstract: OBJECTIVE
  The authors assessed the uptake of Tc-99m pertechnetate in the thyroid using salivary gland scintigraphy in patients with Sjögren syndrome and in healthy controls.
  
  
  METHODS
  Salivary gland scintigraphy and a labial biopsy were performed in 73 patients with Sjögren syndrome. Based on the labial biopsy findings, 32 patients with a histopathologic grade of 1 or 2 were regarded as having early-stage Sjögren syndrome and 41 patients with a grade of 3 or 4 were regarded as having an advanced stage. After the administration of 370 MBq (10 mCi) Tc-99m pertechnetate, dynamic salivary gland scintigraphy was performed for 50 minutes. Lemon juice was used to stimulate the salivary glands, and the thyroid gland was included in the imaging area. Scintigraphy was also performed in an age- and sex-matched control group of 25 healthy persons. The thyroid uptake ratio was calculated for the scintigraphic images and compared among the three groups: healthy controls, patients with early-stage Sjögren syndrome, and those with advanced-stage Sjögren syndrome.
  
  
  RESULTS
  When compared with the control group, the thyroid uptake ratio of the early-stage Sjögren syndrome group was not significantly different, whereas that of the advanced-stage group was significantly lower.
  
  
  CONCLUSIONS
  Thyroid uptake of Tc-99m pertechnetate was less in patients with advanced-stage Sjögren syndrome than in patients with early-stage Sjögren syndrome or in healthy controls. Measuring the thyroid uptake of Tc-99m pertechnetate using salivary gland scintigraphy is an easy and useful method for assessing thyroid disorders in Sjögren syndrome and thus should be performed routinely.
authors.affiliation: Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Taura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Murata
authors.forename: Winn
authors.initials: W
authors.lastname: Aung
authors.forename: Ryuji
authors.initials: R
authors.lastname: Ishida
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Moinul
authors.initials: M
authors.lastname: Hossain
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Norihiko
authors.initials: N
authors.lastname: Okada
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shibuya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012469:Salivary Glands / Q000000981:diagnostic imaging* / Q000378:metabolism; D012470:Salivary Glands, Minor / Q000473:pathology; D012859:Sjogren's Syndrome / Q000000981:diagnostic imaging* / Q000473:pathology; D013670:Sodium Pertechnetate Tc 99m; D013961:Thyroid Gland / Q000000981:diagnostic imaging*
chemical_list: D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m