Tacrolimus-induced nephrotoxicity unmasked by induction of the CYP3A4 system with St John's wort.
Bolley
Renate
R
Zülke
Carl
C
Kammerl
Martin
M
Fischereder
Michael
M
Krämer
Bernhard K
BK
D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004347:Drug Interactions; D016903:Drug Monitoring; D004790:Enzyme Induction / Q000187:drug effects; D005858:Germany; D006801:Humans; D020902:Hypericum; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D016559:Tacrolimus / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics
D000928:Antidepressive Agents; D007166:Immunosuppressive Agents; D028321:Plant Preparations; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D016559:Tacrolimus