Comparative studies on the iron chelators O-TRENSOX and TRENCAMS: selectivity of the complexation towards other biologically relevant metal ions and Al(3+).
Complexation constants have been determined by potentiometric titration and spectrophotometric measurements for several biologically relevant divalent metals (Ca(2+), Cu(2+), Zn(2+)) as well as Al(3+) with the sulfonated tris(8-hydroxyquinolinate) tripodal ligand O-TRENSOX. The values demonstrate great selectivity of O-TRENSOX for Fe(3+) according to the sequence Fe(3+) >>Cu(2+)>Zn(2+)>Ca(2+). This selectivity is compared to that shown by tris(hydroxamate) and tris(catecholate) ligands. (1)H NMR spectroscopy of the diamagnetic complexes have been carried out in (2)H(2)O solutions.
Biaso
Frédéric
F
Laboratoire d'Etudes Dynamiques et Structurales de la Sélectivité, Chimie Biomimétique, UMR CNRS 5616, Université Joseph Fourier, BP 53, F-38041 Cedex 9, Grenoble, France.
Baret
Paul
P
Pierre
Jean Louis
JL
Serratrice
Guy
G
D000535:Aluminum / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D005021:Ethylamines / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006912:Hydroxyquinolines / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D007502:Iron Chelating Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013379:Substrate Specificity
D005021:Ethylamines; D006912:Hydroxyquinolines; D007502:Iron Chelating Agents; D008670:Metals; C461100:trencams; C097548:trensox; D000535:Aluminum; D007501:Iron