[Effects of methotrexate on early pregnancy in mice].
Single s.c. injection of MTX at dosages of 8, 24 and 72 mg.kg-1 on day 7 of gestation was found to have a feticide effect in mice. The mortality of fetuses on day 13 of pregnancy was 18.0%, 55.5% and 60.3%, respectively. Treatment with MTX caused a decrease of serum progesterone level on day 13 of pregnancy. Treatment with MTX at a dosage of 24 mg.kg-1 on day 7-9 of gestation terminated total early pregnancy. MTX combined with hCG 10 U/mouse or progesterone 0.2 mg/mouse was shown to have antagonistic effect to terminate early pregnancy. Synergism of RU486 combined with MTX on termination of early pregnancy in mice was observed.
Wang
N
N
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050.
Guan
M
M
Zheng
W
W
D000020:Abortifacient Agents, Nonsteroidal / Q000494:pharmacology*; D000021:Abortifacient Agents, Steroidal / Q000494:pharmacology; D000818:Animals; D005260:Female; D005493:Folic Acid Antagonists / Q000494:pharmacology; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D015735:Mifepristone / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*
D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D005493:Folic Acid Antagonists; D015735:Mifepristone; D008727:Methotrexate