title: Latex sensitivity in a macaque (Macaca mulatta).
abstract: BACKGROUND AND HISTORY: An adult Macaca mulatta was examined because of a history of multiple episodes of conjunctivitis and an acute, pruritic, dermatitic eruption that affected the axillary and inguinal regions, forearms, thorax, and neck.
  
  
  RESULTS
  Results of corneal staining, examination of skin scrapings and feces, fungal culture, CBC, and a thyroid profile (thyroxine/triiodothyronine concentrations) were negative or normal, with the exception of eosinophilia (1,040/mm3). Examination of a punch biopsy specimen of the skin indicated chronic, nonsuppurative eosinophilic dermatitis. Skin patch testing against 25 contact allergens was negative for a delayed-type hypersensitivity reaction. Allergen-specific IgE testing, using six monkey chow additives, also yielded negative results, but testing against latex revealed a strong positive result (0.74 KU/L) consistent with a latex allergy. A skin prick test performed by use of a latex supernatant revealed significant inflammation at the latex site at 72 h and one week. Vinyl gloves were substituted for latex gloves, and that resulted in a marked decrease in erythema, pruritus, and lichenification with no flares of dermatitis for four years. Repeat skin biopsy fourteen weeks after the original biopsy revealed normal epidermis; however, mild chronic active nonsuppurative, perifolliculitis persisted.
  
  
  CONCLUSIONS
  Latex can induce allergic dermatitis in nonhuman primates and should be included in the differen tial diagnosis for atopic dermatitis.
authors.affiliation: Yale University School of Medicine, New Haven, Connecticut 06520-8016, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Macy
authors.forename: M J
authors.initials: MJ
authors.lastname: Huether
authors.forename: T A
authors.initials: TA
authors.lastname: Beattie
authors.forename: H A
authors.initials: HA
authors.lastname: Findlay
authors.forename: C
authors.initials: C
authors.lastname: Zeiss
mesh_terms: D000818:Animals; D003233:Conjunctivitis, Allergic / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D020315:Latex Hypersensitivity / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D012882:Skin Tests