Precocious puberty in a female with Proteus Syndrome.
Proteus syndrome is a complex disorder comprising malformations and overgrowth of multiple tissues and characterized by its polymorphism and mosaicism. The syndrome is rare and sporadic. Oliveira M da C et al reported the first case of Proteus syndrome associated with precocious puberty in a boy. We are reporting a case of a 7-month old girl with Proteus syndrome who developed a juvenile granulosa cell tumor in one ovary causing precocious puberty. At our knowledge this is the first case of Proteus syndrome with precocious puberty in a female.
Ezzeldin
Kamal M
KM
Department of Radiology, Alnoor Specialist Hospital, Makkah, Kingdom of Saudi Arabia. kamalezzeldin@hot mail.com
Ezzeldin
Asmaa A
AA
Zahrani
Ahmad J
AJ
Al-Zaiem
Maher M
MM
D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications* / Q000473:pathology; D006801:Humans; D007223:Infant; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology; D016715:Proteus Syndrome / Q000150:complications / Q000175:diagnosis; D011629:Puberty, Precocious / Q000209:etiology*; D014057:Tomography, X-Ray Computed