title: A patient with treatment-resistant schizophrenia and cytochrome P4502D6 gene duplication.
abstract: We describe a patient with treatment-resistant schizophrenia who had a duplication in the cytochrome P450IID6 (CYP2D6) gene. This severely ill 71-year-old-woman had responded poorly to several neuroleptics. Molecular genetic study revealed CYP2D6 gene duplication, which results in excessive activity of CYP2D6 that metabolizes various commonly used neuroleptics. The mutation may have contributed to treatment resistance in this case.
authors.affiliation: Department of Psychiatry, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, Japan. chiaki@med.yokohama-cu.ac.jp
authors.forename: C
authors.initials: C
authors.lastname: Kawanishi
authors.forename: T
authors.initials: T
authors.lastname: Furuno
authors.forename: I
authors.initials: I
authors.lastname: Kishida
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
authors.forename: K
authors.initials: K
authors.lastname: Kosaka
mesh_terms: D000368:Aged; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D020440:Gene Duplication; D006801:Humans; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D019389:Cytochrome P-450 CYP2D6