Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities.
Eight secondary metabolites were isolated from submerged cultures of the ascomycete A111-95 during a search for new nematicidal metabolites. (-)-Galiellalactone (7) and compound 2 are metabolites previously obtained from cultures of Galiella rufa while the compounds 1, 3, 4, 5, 6 and 8 (3 and 4 were obtained as an unseparable mixture), were isolated as natural products for the first time. Compound 2, pregaliellalactone (5) and the mixture of 3 and 4 showed nematicidal activities towards Caenorhabditis elegans and Meloidogyne incognita. All compounds showed moderate or weak cytotoxic activities.
Köpcke
Bärbel
B
Institute of Biotechnology and Drug Research (IBWF), Kaiserslautern, Germany.
Johansson
Martin
M
Sterner
Olov
O
Anke
Heidrun
H
D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D001203:Ascomycota; D017173:Caenorhabditis elegans / Q000187:drug effects; D005285:Fermentation; D007928:Lethal Dose 50; D013329:Structure-Activity Relationship; D014431:Tylenchoidea / Q000187:drug effects
D000969:Antinematodal Agents