title: Chordoma of cervical vertebra protruding into the oral cavity.
abstract: A 70-year-old man was admitted to hospital because of oral and cervical masses. Computed tomographic scanning revealed a lobulated mass lesion in the retropharyngeal region, with a protruding extension in the oral cavity and with destruction of the second cervical vertebra. A biopsy was performed under the diagnosis of a retropharyngeal tumor. Histologically, this lesion was composed of vacuolated tumor cells in a solid or cord-like arrangement, with an abundant myxoid matrix. Immunohistochemically, the tumor cells were positive for pancytokeratin, epithelial membrane antigen and S-100 protein. The tumor was diagnosed as chordoma. Chordoma presenting as an intra-oral mass lesion is very rare.
authors.affiliation: First Department of Pathology, Miyazaki Medical College, Miyazaki, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamashita
authors.forename: Kinta
authors.initials: K
authors.lastname: Hatakeyama
authors.forename: Kousuke
authors.initials: K
authors.lastname: Marutsuka
authors.forename: Seigo
authors.initials: S
authors.lastname: Fujita
authors.forename: Seiji
authors.initials: S
authors.lastname: Ono
authors.forename: Koji
authors.initials: K
authors.lastname: Torihara
authors.forename: Shozo
authors.initials: S
authors.lastname: Tamura
authors.forename: Shizuo
authors.initials: S
authors.lastname: Komune
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Asada
mesh_terms: D000368:Aged; D002574:Cervical Vertebrae; D002817:Chordoma / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology*; D018396:Mucin-1 / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D013125:Spinal Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D018396:Mucin-1; D009418:S100 Proteins; D007633:Keratins