Controlled-release naproxen using micronized ethyl cellulose by wet-granulation and solid-dispersion method.
This study has been undertaken to develop a controlled-release tablet dosage form of naproxen using ethocel (ethyl cellulose) as the rate-controlling polymer. The formulations were made by employing the conventional wet-granulation method and the solid-dispersion method. Tablets made by both methods were compared for their controlled-release dissolution profiles. Both methods were useful in developing the controlled-release formulations of naproxen with desirable properties. However, the amount of polymer required to make a formulation with the desired release profile was 33% less via solid dispersion than via wet granulation. A cumulative 88% of naproxen was released from the solid-dispersion formulation, compared with 84% from the wet-granulation formulation.
Iqbal
Zabed
Z
Long Island University, Brooklyn, NY, USA.
Babar
Almas
A
Ashraf
Muhammad
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations; D009288:Naproxen / Q000008:administration & dosage*; D011108:Polymers / Q000737:chemistry; D012597:Sclerosing Solutions / Q000737:chemistry*; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D011108:Polymers; D012597:Sclerosing Solutions; D013607:Tablets; D009288:Naproxen; C013517:ethyl cellulose; D002482:Cellulose