title: Tuberculosis should not be considered an AIDS-defining illness in areas with a high tuberculosis prevalence.
abstract: OBJECTIVE
  To assess the prognosis of human immunodeficiency virus (HIV) associated tuberculosis in a high tuberculosis prevalence setting.
  
  
  METHODS
  Survival and subsequent AIDS-defining illnesses (ADI) of patients with tuberculosis were compared with patients remaining tuberculosis-free in a prospective cohort study in two university-affiliated adult HIV clinics in Cape Town.
  
  
  RESULTS
  Tuberculosis without prior or simultaneous ADI was diagnosed in 141 patients. CD4+ T-lymphocyte count was >200 cells/microl in 67% of the incident tuberculosis cases. Survival in tuberculosis patients was comparable to that of patients with oral hairy leukoplakia and/or oral candidiasis (median = 23.6 vs. 27.8 months respectively; P = 0.59, adjusted hazard ratio [AHR] = 0.87; 95%CI 0.63-1.58), and better than in patients with AIDS (median = 11.5 months; P < 0.001, AHR = 2.37; 95% CI 1.93-4.66). Subsequent ADI were less frequent in tuberculosis than in AIDS patients (AHR = 0.36; 95%CI 0.23-0.58). Survival of patients with pulmonary or extra-pulmonary tuberculosis was similar (P = 0.32).
  
  
  CONCLUSIONS
  Tuberculosis in HIV-infected patients from areas endemic with tuberculosis occurs across a wide spectrum of immune suppression and has a considerably better prognosis than other ADI. Inclusion of tuberculosis in the clinical case definition of AIDS in such areas should be reconsidered.
authors.affiliation: Faculty of Health Sciences, University of Cape Town, Observatory, South Africa.
authors.forename: M
authors.initials: M
authors.lastname: Badri
authors.forename: R
authors.initials: R
authors.lastname: Ehrlich
authors.forename: T
authors.initials: T
authors.lastname: Pulerwitz
authors.forename: R
authors.initials: R
authors.lastname: Wood
authors.forename: G
authors.initials: G
authors.lastname: Maartens
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D000328:Adult; D015496:CD4-Positive T-Lymphocytes; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D015995:Prevalence; D011379:Prognosis; D016019:Survival Analysis; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000453:epidemiology*