title: Outbreak of African tick-bite fever in six Italian tourists returning from South Africa.
abstract: In May 1999, a cluster of cases of African tick-bite fever was detected in six Italian tourists who had returned from South Africa. All of the patients had moderate fever and cutaneous eschars. Regional lymphangitis was observed in three of the patients and skin rash in two. By comparing the number of eschars with the number of detectable bite sites it was suggested that at least two-thirds of the biting vectors were capable of transmitting Rickettsia africae. The clinical course of disease was mild in all cases, and all but one of the patients recovered spontaneously before antibiotic treatment was initiated. The diagnosis of African tick-bite fever was confirmed serologically using both microimmunofluorescence and Western blot tests.
authors.affiliation: Department of Infectious Diseases, Ospedale S. Martino, Belluno, Italy. beppe.caruso@libero.it
authors.forename: G
authors.initials: G
authors.lastname: Caruso
authors.forename: C
authors.initials: C
authors.lastname: Zasio
authors.forename: F
authors.initials: F
authors.lastname: Guzzo
authors.forename: C
authors.initials: C
authors.lastname: Granata
authors.forename: V
authors.initials: V
authors.lastname: Mondardini
authors.forename: E
authors.initials: E
authors.lastname: Guerra
authors.forename: E
authors.initials: E
authors.lastname: Macrì
authors.forename: P
authors.initials: P
authors.lastname: Benedetti
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001733:Bites and Stings; D015153:Blotting, Western; D004196:Disease Outbreaks; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007558:Italy / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D012281:Rickettsia / Q000145:classification* / Q000302:isolation & purification; D012282:Rickettsia Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D012698:Serologic Tests; D012720:Severity of Illness Index; D013019:South Africa / Q000453:epidemiology; D013987:Ticks; D014195:Travel
chemical_list: D000900:Anti-Bacterial Agents