title: Electrical restitution and cardiac fibrillation.
abstract: Combined experimental and theoretical work has shown that restitution properties of the cardiac action potential duration and conduction velocity contribute to breakup of reentrant wavefronts during cardiac fibrillation independent of preexisting electrophysiologic heterogeneities in the tissue. Developing therapies that favorably alter these cardiac electrical restitution properties are a promising new approach to preventing fibrillation.
authors.affiliation: Department of Medicine, UCLA School of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90095-1760, USA. jweiss@mednet.ucla.edu
authors.forename: James N
authors.initials: JN
authors.lastname: Weiss
authors.forename: Peng-Sheng
authors.initials: PS
authors.lastname: Chen
authors.forename: Zhilin
authors.initials: Z
authors.lastname: Qu
authors.forename: Hrayr S
authors.initials: HS
authors.lastname: Karagueuzian
authors.forename: Shin-Fong
authors.initials: SF
authors.lastname: Lin
authors.forename: Alan
authors.initials: A
authors.lastname: Garfinkel
mesh_terms: D004594:Electrophysiology; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D017180:Tachycardia, Ventricular / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D014693:Ventricular Fibrillation / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control*