title: [Tc-99m ciprofloxacin in clinically selected patients for peripheral osteomyelitis, spondylodiscitis and fever of unknown origin--preliminary results].
abstract: OBJECTIVE
  Retrospective evaluation of Tc-99m ciprofloxacin (infection) scintigraphy consecutively performed in a series of patients clinically suspected for peripheral osteomyelitis (OM), spondylodiscitis (SD) and fever of unknown origin (FUO).
  
  
  METHODS
  A total of 20 patients clinically suspected for OM (n = 12), SD (n = 3) and FUO (n = 5) were included in our retrospective analysis. The additional criterion was a positive 3-phase bone scan for OM, or a 2-phase bone scan in case of SD. Planar whole body scans and static acquisitions were performed 1 and 4 h after application of 370 MBq Tc-99m ciprofloxacin. In 10 patients with suspected OM, additional immunoscintigraphy using Tc-99m labelled monoclonal antibodies (Mab BW 250/183) was performed and the correlation of infection to bloodpool and antigranulocyte scintigraphy was analysed.
  
  
  RESULTS
  OM: Bacterial infection was confirmed in 8 of 15 lesions. Infection demonstrated true positive (TP) results in 7 of 8, true negative (TN) results in 2 of 7, false positive (FP) results in 5 of 7 patients and one false negative (FN) result. A strong correlation could be demonstrated between T/NT ratios of infection and bloodpool Tc-99m medronate imaging (r = 0.84, 0.88) and between infection and BW 250/183 (r = 0.92, 0.90). Using a threshold of 2.0 for T/NT ratio, only TP results could be observed whereas a T/NT in the range of 1.0-2.0 could not discriminate between septic and aseptic inflammation. Concordant results with Mab BW 250/183 could only be observed in 5 of 10 patients (4 TP, 1 TN) by showing 4 FP and 1 FN lesions with IF.
  
  
  CONCLUSIONS
  Non-specific uptake of infection can be observed in a variety of clinical situations with moderate uptake, by showing a strong correlation with blood-pool imaging. Nevertheless, intense uptake may be specific for septic inflammation.
authors.affiliation: Abteilung für Nuklearmedizin und Endokrinologie, Landeskrankenhaus Klagenfurt, Osterreich. H-J.Gallowitsch@lkh-klu.at
authors.forename: H J
authors.initials: HJ
authors.lastname: Gallowitsch
authors.forename: M
authors.initials: M
authors.lastname: Heinisch
authors.forename: P
authors.initials: P
authors.lastname: Mikosch
authors.forename: E
authors.initials: E
authors.lastname: Kresnik
authors.forename: G
authors.initials: G
authors.lastname: Kumnig
authors.forename: I
authors.initials: I
authors.lastname: Gomez
authors.forename: P
authors.initials: P
authors.lastname: Lind
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000000981:diagnostic imaging; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002939:Ciprofloxacin / Q000031:analogs & derivatives*; D003937:Diagnosis, Differential; D015299:Discitis / Q000000981:diagnostic imaging*; D005260:Female; D005335:Fever of Unknown Origin / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010019:Osteomyelitis / Q000000981:diagnostic imaging*; D016719:Radioimmunodetection; D019275:Radiopharmaceuticals
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C431804:Technetium Tc 99m ciprofloxacin; D002939:Ciprofloxacin
vernacular_title: Tc-99m-Ciprofloxacin bei Verdacht auf periphere Osteomyelitis, Spondylodiszitis und Fieber unklarer Genese in einem klinisch selektierten Patientengut--vorläufige Ergebnisse.