[Experimental study of daicong solution on brain M receptor in dementia model of aged rats].
OBJECTIVE
To explore the effect of Daicong Solution (DCS) on M receptor in brain of aged rat model of dementia.


METHODS
The effects of DCS on M receptor in brain of dementia model of learning and memory function hindrance were observed, the basal nuclei were ruined by destroying bilateral electrolytic method in 22-month-old rats.


RESULTS
Significant difference was shown in comparing the M receptor in the two groups treated by different dosages of DCS with that in the model control group (P < 0.01), significant difference also displayed in comparison of the DCS treated groups and Naofukang treated group (P < 0.01).


CONCLUSIONS
DCS has marked effects in elevating the number and affinity of M receptor in brain of aged rat dementia model and could improve its learning and memory function, the effect was superior to that of Naofukang.
Yue
Q
Q
Department of Microbiology, Weifang Medical College, Shandong (261042).
Zhao
S
S
Gao
J
J
D000375:Aging / Q000187:drug effects; D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D001479:Basal Ganglia / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004558:Electric Stimulation; D005260:Female; D008297:Male; D008568:Memory / Q000187:drug effects; D051381:Rats; D011976:Receptors, Muscarinic / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D011976:Receptors, Muscarinic