title: Efficient loading of sulfonamide safety-catch linkers by Fmoc amino acid fluorides.
abstract: [reaction: see text] Fmoc-protected amino acid fluorides were found to be excellent reagents for the acylation of sulfonamide safety-catch linkers (SCL) suitable for the subsequent preparation of peptide C-terminal thioesters. High loadings were obtained on different types of resins with low levels of epimerization.
authors.affiliation: Jerini AG, Rudower Chaussee 29, 12489 Berlin, Germany. ingenito@jerini.com
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ingenito
authors.forename: Dijana
authors.initials: D
authors.lastname: Dreznjak
authors.forename: Stefan
authors.initials: S
authors.lastname: Guffler
authors.forename: Holger
authors.initials: H
authors.lastname: Wenschuh