title: Effect of resveratrol on platelet aggregation in vivo and in vitro.
abstract: OBJECTIVE
  Low or moderate consumption of red wine has a greater benefit than the consumption of other beverages in the prevention of atherosclerosis and coronary heart disease and this is increasingly attributed to the polyphenol compounds in red wine, such as resveratrol. In the present study, we investigated the effect of resveratrol on platelet aggregation in vitro and in vivo.
  
  
  METHODS
  Platelet aggregation in rabbits and normal subjects was measured using Born's method.
  
  
  RESULTS
  Resveratrol, at 10 - 1000 micromol/L, significantly inhibited platelet aggregation in vitro induced by collagen, thrombin, and ADP in healthy subjects. The inhibitory effect was concentration-dependent. Hypercholesterolemia induced by high-cholesterol diet enhanced ADP-induced platelet aggregation. Resveratrol 4 mg x kg(-1) x d(-1) inhibited ADP-induced platelet aggregation in vivo despite no changes in serum lipid levels.
  
  
  CONCLUSIONS
  Resveratrol inhibits platelet aggregation both in vitro and in vivo. This may be one of the mechanisms by which resveratrol prevents atherosclerosis.
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Wang
authors.forename: Jiangang
authors.initials: J
authors.lastname: Zou
authors.forename: Yuanzhu
authors.initials: Y
authors.lastname: Huang
authors.forename: Kejiang
authors.initials: K
authors.lastname: Cao
authors.forename: Yinan
authors.initials: Y
authors.lastname: Xu
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Wu
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control*; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D008078:Cholesterol, LDL; D008055:Lipids; D010975:Platelet Aggregation Inhibitors; D013267:Stilbenes; D000077185:Resveratrol