title: Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide--a potential antileishmanial agent.
abstract: Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)-N-phenylacetamide (2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) in reducing the parasite load both in the spleen and liver at a much lower concentration in hamster models. The results suggest that the compound could be exploited as an antileishmanial drug.
authors.affiliation: Steroid and Terpenoid Chemistry Division, Indian Institute of Chemical Biology, 4 Raja SC Mullick Road, Jadavpur, 700 032, Kolkata, India. npsahu@iicb.res.in
authors.forename: Niranjan P
authors.initials: NP
authors.lastname: Sahu
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Pal
authors.forename: Nirup B
authors.initials: NB
authors.lastname: Mandal
authors.forename: Sukdeb
authors.initials: S
authors.lastname: Banerjee
authors.forename: Mausumi
authors.initials: M
authors.lastname: Raha
authors.forename: Ashis P
authors.initials: AP
authors.lastname: Kundu
authors.forename: Anirban
authors.initials: A
authors.lastname: Basu
authors.forename: Monidipa
authors.initials: M
authors.lastname: Ghosh
authors.forename: Keshab
authors.initials: K
authors.lastname: Roy
authors.forename: Santu
authors.initials: S
authors.lastname: Bandyopadhyay
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D000083:Acetanilides; D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D006224:Cricetinae; D007893:Leishmania donovani / Q000166:cytology / Q000187:drug effects / Q000254:growth & development; D007896:Leishmaniasis / Q000097:blood / Q000188:drug therapy / Q000201:enzymology / Q000469:parasitology; D008099:Liver / Q000187:drug effects / Q000469:parasitology; D008647:Mesocricetus; D015394:Molecular Structure; D013154:Spleen / Q000187:drug effects / Q000469:parasitology; D013997:Time Factors
chemical_list: C470913:2-(2-methylquinolin-4-ylamino)-N-phenylacetamide; D000081:Acetamides; D000083:Acetanilides; D000634:Aminoquinolines; D000981:Antiprotozoal Agents