title: Eccrine squamous syringometaplasia and syringomatous hyperplasia in association with linear scleroderma.
abstract: It is now well recognized that syringomatous hyperplasia with squamous syringometaplasia is a type of pseudoepitheliomatous hyperplasia responding to a variety of stimuli. We report a case of linear scleroderma with this process. Histopathology of the lesion showed numerous solid and cystic epithelial structures with squamous metaplasia within typical sclerodermatous skin lesions. Although the pathogenesis of the process remains unclear, dermal-derived growth factors in scleroderma and/or the mechanical effect of sclerosis could stimulate the proliferative response of eccrine epithelium. To the best of our knowledge, the association of syringomatous hyperplasia with eccrine squamous syringometaplasia and linear scleroderma has not been described previously.
authors.affiliation: Department of Dermatology, Asahikawa Medical College, Japan. mc9@asahikawa-med.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakai
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Satoh
authors.forename: Akira
authors.initials: A
authors.lastname: Manabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakane
authors.forename: Akemi
authors.initials: A
authors.lastname: Ishida-Yamamoto
authors.forename: Hajime
authors.initials: H
authors.lastname: Iizuka
mesh_terms: D002648:Child; D004439:Eccrine Glands / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D012594:Scleroderma, Localized / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology*; D013543:Sweat Gland Diseases / Q000150:complications* / Q000473:pathology