title: Removal of lepirudin, a recombinant hirudin, by hemodialysis, hemofiltration, or plasmapheresis.
abstract: Lepirudin (recombinant hirudin), a direct thrombin inhibitor, is an effective alternative method of anticoagulation in patients with heparin-induced thrombocytopenia. However, because it is eliminated by the kidneys, the half-life of lepirudin may be substantially prolonged in patients with renal failure. Patients undergoing hemodialysis must be closely monitored, and therapy must be individualized based on each patient's ability to clear the drug. Current literature on the removal of lepirudin by dialysis or plasmapheresis is limited, but available data suggest that lepirudin can be removed with these methods. The ability of filtration systems to remove lepirudin from the blood is highly dependent on the membrane material used in the system. Understanding the effects of hemodialysis, hemofiltration, and plasmapheresis on lepirudin levels is important, especially since no antidote is available to treat elevated serum lepirudin concentrations.
authors.affiliation: Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, PA 19104, USA.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Willey
authors.forename: Simon
authors.initials: S
authors.lastname: de Denus
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Spinler
mesh_terms: D000925:Anticoagulants / Q000097:blood* / Q000493:pharmacokinetics; D005343:Fibrinolytic Agents / Q000032:analysis; D006440:Hemofiltration / Q000379:methods / Q000706:statistics & numerical data; D006629:Hirudins / Q000031:analogs & derivatives / Q000097:blood* / Q000493:pharmacokinetics; D006801:Humans; D010956:Plasmapheresis / Q000379:methods / Q000706:statistics & numerical data; D011994:Recombinant Proteins / Q000097:blood* / Q000493:pharmacokinetics; D006435:Renal Dialysis / Q000379:methods / Q000706:statistics & numerical data
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D006629:Hirudins; D011994:Recombinant Proteins; C083544:lepirudin