[Effect of dimethoate on the expression of c-fos gene in skeletal muscle].
To elucidate the effect of organophosphate pesticides on the expression of immediate early gene in skeletal muscle, the concentrations of c-fos mRNA and protein were measured by RT-PCR and western dot blot techniques. The result showed that c-fos mRNA and protein were significantly increased in skeletal muscle of rat after dosing with dimethoate. These results indicated that c-fos might act as transcription factor and regulate other gene expression during the early period of organophosphate intoxication.
Yang
D
D
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Niu
Y
Y
He
F
F
D000818:Animals; D004117:Dimethoate / Q000633:toxicity*; D017781:Genes, Immediate-Early; D017874:Immediate-Early Proteins / Q000096:biosynthesis / Q000235:genetics; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D009157:Myasthenia Gravis / Q000139:chemically induced / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar
D017874:Immediate-Early Proteins; D007306:Insecticides; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D004117:Dimethoate