title: [Intradermal tests with vasomotor agents in chronic noninfectious rhinitis].
abstract: The aim of this prospective study was to examine the skin reactivity to four vasomotor agents in chronic, non-infectious rhinitis patients, and to determine whether non-allergic rhinitis (NAR) patients differ from allergic rhinitis (AR) patients. Seventy four patients with NAR and 44 with AR were subjected to intradermal testing with papaverine (5 mg/ml), metacholine (0.02, 0.2 and 2.0 mg/ml), histamine (0.01, 0.1, 1.0 and 10.0 micrograms/ml), compound 48/80 (0.01, 0.1, 1.0 and 10.0 micrograms/ml) and saline. It was found that the frequency of pathological skin reactivity to papaverine in the patients with NAR (25/74) was significantly greater (p = 5.0 x 10(-3)) then in the patients with AR (4/44). No significant inter-group difference in skin reactivity to metacholine, histamine, compound 48/80 and saline was observed. The frequency of the total pathological skin reactivity to vasomotor agents, singly and in combinations, in patients with NAR (80%) was significantly greater (p = 0.03) than in patients with AR (61%). These findings suggested that the pathological skin reactivity to papaverine, metacholine, histamine and compound 48/80 was a feature of chronic, non-infectious rhinitis patients and it was more frequently associated with non-allergic than with the allergic etiology of rhinitis.
authors.forename: Dusanka N
authors.initials: DN
authors.lastname: Milosević
authors.forename: Ljiljana B
authors.initials: LB
authors.lastname: Janosević
authors.forename: Slobodanka B
authors.initials: SB
authors.lastname: Janosević
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006632:Histamine / Q000276:immunology; D006801:Humans; D007428:Intradermal Tests; D008297:Male; D016210:Methacholine Chloride / Q000276:immunology; D008875:Middle Aged; D010208:Papaverine / Q000276:immunology; D011446:Prospective Studies; D012220:Rhinitis / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*; D014662:Vasoconstrictor Agents / Q000276:immunology*; D014665:Vasodilator Agents / Q000276:immunology*; D003189:p-Methoxy-N-methylphenethylamine / Q000276:immunology
chemical_list: D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D016210:Methacholine Chloride; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D010208:Papaverine
vernacular_title: Intradermalni testovi vazomotornim agensima kod hronicnog, neinfektivnog rinitisa.