title: Treating cytomegalovirus retinitis-related retinal detachment by combining silicone oil tamponade and ganciclovir implant.
abstract: OBJECTIVE
  With the efficacy of pars plana vitrectomy and silicone oil infusion in treating cytomegalovirus (CMV) retinitis-related retinal detachment and the success of the ganciclovir implant in controlling CMV retinitis, we sought to evaluate the possible benefits of combining these two procedures in one surgical operation.
  
  
  METHODS
  A retrospective review of 10 patients was conducted. Each patient was diagnosed with a CMV retinitis-related retinal detachment and treated with pars plana vitrectomy and silicone oil infusion, with simultaneous placement of a ganciclovir implant. Parameters evaluated included location of retinal detachment, reattachment rate, pre- and post-operative Snellen visual acuity, pre- and post-operative CMV retinitis activity and location, and complications of the combined procedure.
  
  
  RESULTS
  Overall anatomic reattachment was achieved in all 10 patients. Four patients presented with macular involvement of their retinal detachments. Three of these patients experienced significant post-operative improvement in visual acuity. Surgery preserved visual acuity in the 6 patients who presented with macula attached. Best postoperative acuity was better than or equal to 20/100 in 7 (70%) patients. All 3 CMV retinitis patients with inactive retinitis preoperatively remained free of retinitis for the duration of follow up. At last follow up, 8/10 (80%) showed no active CMV retinitis and no patients experienced progression of their retinitis.
  
  
  CONCLUSIONS
  Results of this series indicate that patients benefit from excellent anatomic reattachment rates, preservation or improvement of visual acuity in most cases, and extended control of their CMV retinitis. Combining the two procedures appears viable. Further study is warranted to assess definitive anatomic and functional outcomes resulting from this new technique.
authors.affiliation: Department of Ophthalmology, Indiana University School of Medicine, Indianapolis 46202, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Martidis
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Danis
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Ciulla
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D017726:Cytomegalovirus Retinitis / Q000150:complications / Q000188:drug therapy*; D004343:Drug Implants; D015774:Ganciclovir / Q000008:administration & dosage*; D006801:Humans; D012163:Retinal Detachment / Q000209:etiology / Q000601:surgery*; D012189:Retrospective Studies; D012827:Silicone Oils / Q000627:therapeutic use*; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy
chemical_list: D000998:Antiviral Agents; D004343:Drug Implants; D012827:Silicone Oils; D015774:Ganciclovir