[Effects of T-type calcium channel blockers on spontaneous meiotic maturation of mouse ovarian oocytes in vitro].
We studied the effects of blockers of the T-type Ca2+ channels on resumption of meiosis and spontaneous meiotic maturation of murine ovarial oocytes in vitro. We found that the efficiency of suppression of oocyte maturation by blockers of the Ca2+ channels increases in the following succession: amiloride hydrochloride, mebifradil, NiCl2. It is supposed that there is a possibility to use blockers of the T-type Ca2+ channels for creation of new combined intrauterine contraceptives.
Hotsuliak
Ia M
IaM
A.A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kiev.
Berdyieva
T K
TK
Libert
S V
SV
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002478:Cells, Cultured; D005260:Female; D008540:Meiosis / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D009532:Nickel / Q000494:pharmacology*; D009865:Oocytes / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D010053:Ovary / Q000166:cytology* / Q000502:physiology
D002121:Calcium Channel Blockers; C022838:nickel chloride; D000584:Amiloride; D009532:Nickel
Vlyv blokatoriv kal'tsievykh kanaliv t-typu na spontanne meĭotychne dozrivannia ovarial'nykh ootsytiv mysheĭ in vitro.