Primary epitheliotropic intestinal T-cell lymphoma in a horse.
A 17-year-old Quarterhorse gelding with a clinical diagnosis of protein-losing enteropathy was submitted for necropsy following a 4-5-month duration of weight loss, decreased appetite, and hypoproteinemia. Gross findings included multiple 1-2-cm diameter ulcers on the luminal surfaces of the duodenum and ileum. Histologic examination revealed individual large, round cells infiltrating much of the mucosal epithelium of the duodenum, jejunum, ileum, and colon in addition to multifocal areas of ulceration. Similar round cells infiltrated Brunner's glands and expanded the submucosa beneath the foci of ulceration. Immunohistochemical staining indicated the round cell population was of T-lymphocyte origin. Several features of this equine neoplasm bear similarities to enteropathy-associated T-cell lymphoma in humans.
Pinkerton
Marie E
ME
Department of Veterinary Clinical Medicine, University of Illinois, Urbana 61801, USA.
Bailey
Keith L
KL
Thomas
Kathy K
KK
Goetz
Thomas E
TE
Valli
Victor E
VE
D000818:Animals; D001344:Autopsy / Q000662:veterinary; D006734:Horse Diseases / Q000175:diagnosis / Q000473:pathology*; D006736:Horses; D007019:Hypoproteinemia / Q000662:veterinary; D007150:Immunohistochemistry / Q000662:veterinary; D007414:Intestinal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010437:Peptic Ulcer / Q000473:pathology / Q000662:veterinary; D015431:Weight Loss