title: Glomus jugulare tumor: tumor control and complications after stereotactic radiosurgery.
abstract: BACKGROUND
  We evaluated toxicity and long-term efficacy of stereotactic radiosurgery in patients with symptomatic or progressive glomus jugulare tumors.
  
  
  METHODS
  Twenty-five consecutive patients (age, 30-88 years; 17 women, 8 men) who underwent stereotactic radiosurgery with the Leksell Gamma Knife (dose, 12-18 Gy) were prospectively followed. MRI and clinical examinations were performed at 6 months and 1, 2, and 3 years, and then every 2 years.
  
  
  RESULTS
  None of the tumors increased in size, 17 were stable, and 8 decreased (median imaging follow-up, 35 months; range, 10-113 months). Symptoms subsided in 15 patients (60%); vertigo occurred in 1, but balance improved with vestibular training (median clinical follow-up, 37 months; range, 11-118 months). No other new or progressive neuropathy of cranial nerves V-XII developed.
  
  
  CONCLUSIONS
  Stereotactic radiosurgery can achieve excellent tumor control with low risk of morbidity in the treatment of glomus jugulare tumors. The lower cranial nerves can safely tolerate a radiosurgical dose of 12 to 18 Gy.
authors.affiliation: Division of Radiation Oncology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA. foote.robert@mayo.edu
authors.forename: Robert L
authors.initials: RL
authors.lastname: Foote
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Pollock
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Gorman
authors.forename: Paula J
authors.initials: PJ
authors.lastname: Schomberg
authors.forename: Scott L
authors.initials: SL
authors.lastname: Stafford
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Link
authors.forename: Robert W
authors.initials: RW
authors.lastname: Kline
authors.forename: Scott E
authors.initials: SE
authors.lastname: Strome
authors.forename: Jan L
authors.initials: JL
authors.lastname: Kasperbauer
authors.forename: Kerry D
authors.initials: KD
authors.lastname: Olsen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005925:Glomus Jugulare Tumor / Q000401:mortality / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery*; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016634:Radiosurgery / Q000009:adverse effects* / Q000295:instrumentation; D016896:Treatment Outcome