title: Human herpesvirus 6 viremia in bone marrow transplant recipients: clinical features and risk factors.
abstract: Human herpesvirus 6 (HHV-6) infection was studied in 82 bone marrow transplant (BMT) recipients (72 allogeneic, 10 autologous). All recipients and 30 donors were seropositive for HHV-6 antibody at the time of bone marrow transplantation. Thirty-one recipients (37.8%) had HHV-6 viremia 2-4 weeks after transplantation. The incidence of HHV-6 viremia was significantly higher among allogeneic BMT recipients than in autologous BMT recipients (P=.011). Therefore, the following analyses of allogeneic BMT recipients were carried out (n=72). Geometric mean antibody titers (log(10)) were significantly higher in recipients without viremia than in those with viremia (1.84+/-0.39 vs. 1.61+/-0.42; P=.022). Logistic regression analysis demonstrated that leukemia or lymphoma is an independent risk factor (P=.031) for HHV-6 viremia. Rash occurring within 1 month after transplantation was observed in 17 (54.8%) of 31 recipients with HHV-6 viremia but in only 8 (19.5%) of 41 recipients without HHV-6 viremia (P=.001).
authors.affiliation: Laboratory of Virology, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, 4668550 Japan. tetsushi@med.nagoya-u.ac.jp
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Yoshizo
authors.initials: Y
authors.lastname: Asano
authors.forename: Masaru
authors.initials: M
authors.lastname: Ihira
authors.forename: Kyoko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ohashi
authors.forename: Sadao
authors.initials: S
authors.lastname: Suga
authors.forename: Kazuko
authors.initials: K
authors.lastname: Kudo
authors.forename: Keizo
authors.initials: K
authors.lastname: Horibe
authors.forename: Seiji
authors.initials: S
authors.lastname: Kojima
authors.forename: Koji
authors.initials: K
authors.lastname: Kato
authors.forename: Takaharu
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Nishiyama
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006566:Herpesviridae Infections / Q000453:epidemiology* / Q000503:physiopathology* / Q000821:virology; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D012307:Risk Factors; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014766:Viremia / Q000821:virology*
chemical_list: D000914:Antibodies, Viral