The influence of Na+ ions on histamine secretion from mast cells induced by NGF or compound 48/80.
It has been demonstrated that the release of histamine from mast cells by cytokines is strongly dependent on extracellular Ca2+ and Na+ ions. The results of our current research indicate that the removal of extracellular Na+ enhances NGF induced histamine release, but reduces induction by compound 48/80, suggesting that different mechanisms are involved in the secretory process induced by these agents.
Stempelj
Mateja
M
Institute of Pharmacology and Experimental Toxicology, Faculty of Medicine, 1000 Ljubljana, Slovenia.
Carman-Krzan
Marija
M
Ferjan
Ilonka
I
D000818:Animals; D002118:Calcium / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects*; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D020932:Nerve Growth Factor / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D003189:p-Methoxy-N-methylphenethylamine; D020932:Nerve Growth Factor; D012964:Sodium; D002118:Calcium