title: Non-herpetic fulminant meningoencephalitis with periodic lateralised epileptiform discharges.
abstract: This report concerns two patients with fulminant meningoencephalitis presenting in status epilepticus with periodic lateralised epileptiform discharges (PLEDs) observed on electroencephalogram. The titer of herpes simplex virus type 1 antibody was not elevated in either serum or cerebrospinal fluid, and acyclovir was not effective for either patient. Corticosteroid therapy was dramatically effective, however, suggesting that autoimmune inflammatory diseases were the underlying systemic disorders. PLEDs can thus be associated with steroid-responsive inflammatory meningoencephalitis.
authors.affiliation: Third Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. anakamu@hsp.md.shinshu-u.ac.jp
authors.forename: Akinori
authors.initials: A
authors.lastname: Nakamura
authors.forename: Takao
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Matsuda
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Shimada
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yanagisawa
authors.forename: Shu-ich
authors.initials: SI
authors.lastname: Ikeda Si
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D004569:Electroencephalography / Q000706:statistics & numerical data; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D008590:Meningoencephalitis / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D013226:Status Epilepticus / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000305:Adrenal Cortex Hormones