title: Siberian hamster: a new indoor source of allergic sensitization and respiratory disease.
abstract: BACKGROUND
  The identification of 'unknown' allergic sensitizations may determine the prognosis and treatment of patients with respiratory airway disease. Currently, the presence in homes of 'exotic' animals as pets is increasing. In this article the Siberian hamster or dwarf hamster (Phodopus sungorus) was identified as a new indoor source of aeroallergens and respiratory disease.
  
  
  METHODS
  The subjects were six outpatients who were treated for asthma and rhinitis. Siberian hamster hair extract was prepared with a standard wt/vol method, and patients were skin-prick tested with the extract. Serum-specific immunoglobulin (Ig)E against the Siberian hamster, common hamster (Cricetus cricetus) and golden hamster (Mesocricetus auratus) was determined. IgE-immunoblotting was also performed for all six sera. Specific bronchial challenge was carried out with the Siberian hamster extract.
  
  
  RESULTS
  Skin prick tests (SPT) with the Siberian hamster extract, and specific IgE-antibodies against Siberian hamster, were strongly positive in all six patients. Determinations of specific IgE-antibodies against C. cricetus and M. auratus were negative in all patients. IgE-immunoblotting of the sera revealed two IgE-binding fractions (MW 18 and 32 kDa) in five of the six sera. Specific bronchial provocation tests resulted in early asthmatic responses in the two patients who were challenged.
  
  
  CONCLUSIONS
  The present study reveals the Siberian hamster to be able to induce both sensitization and disease, and this species of hamster should be taken into consideration as a cause of respiratory disease in exposed subjects. A noteworthy finding was the lack of sensitization in our patients to common hamster allergens (M. auratus and C. cricetus) that are usually tested when hamster allergy is suspected.
authors.affiliation: Department of Allergy, Hospital Clínic Universitari, Valencia, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Bertó
authors.forename: A
authors.initials: A
authors.lastname: Peláez
authors.forename: E
authors.initials: E
authors.lastname: Fernández
authors.forename: M
authors.initials: M
authors.lastname: Lombardero
authors.forename: M
authors.initials: M
authors.lastname: Ferrer
mesh_terms: D000328:Adult; D016902:Air Pollution, Indoor / Q000009:adverse effects / Q000032:analysis; D000485:Allergens / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D000818:Animals; D000918:Antibody Specificity / Q000276:immunology; D001985:Bronchial Provocation Tests; D002352:Carrier Proteins / Q000097:blood / Q000276:immunology; D006224:Cricetinae; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007114:Immunization; D015151:Immunoblotting; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D008297:Male; D017111:Phodopus / Q000276:immunology*; D011852:Radioallergosorbent Test; D012130:Respiratory Hypersensitivity / Q000097:blood / Q000209:etiology; D012882:Skin Tests; D013030:Spain
chemical_list: D000485:Allergens; D002352:Carrier Proteins; D007073:Immunoglobulin E