title: Treatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical properties.
abstract: Recently the researchers found that an extract of Fucus vesiculosus, which is a type of seaweed, promotes the contraction of fibroblast-populated collagen gels through increased expression of integrin molecules. In this study, they investigated the effects of topical application of an aqueous extract of this alga on the thickness and the mechanical properties of human skin. A gel formulation that included 1% of the extract was applied topically to human cheek skin twice daily for five weeks. A significant decrease in skin thickness measured by B-mode ultrasound was elicited, as was a significant improvement in elasticity measured with a Cutometer as compared with controls. In cheek skin, the thickness normally increases and the elasticity usually decreases with age. These results suggest that the Fucus vesiculosus extract possesses anti-aging activities and should be useful for a variety of cosmetics.
authors.affiliation: Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fujimura
authors.forename: Kazue
authors.initials: K
authors.lastname: Tsukahara
authors.forename: Shigeru
authors.initials: S
authors.lastname: Moriwaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitahara
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Sano
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Takema
mesh_terms: D000287:Administration, Topical; D000328:Adult; D001696:Biomechanical Phenomena; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D010919:Placebos; D012624:Seaweed; D012867:Skin / Q000033:anatomy & histology*
chemical_list: D010919:Placebos