Electrical restitution and cardiac fibrillation.
Combined experimental and theoretical work has shown that restitution properties of the cardiac action potential duration and conduction velocity contribute to breakup of reentrant wavefronts during cardiac fibrillation independent of preexisting electrophysiologic heterogeneities in the tissue. Developing therapies that favorably alter these cardiac electrical restitution properties are a promising new approach to preventing fibrillation.
Weiss
James N
JN
Department of Medicine, UCLA School of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90095-1760, USA. jweiss@mednet.ucla.edu
Chen
Peng-Sheng
PS
Qu
Zhilin
Z
Karagueuzian
Hrayr S
HS
Lin
Shin-Fong
SF
Garfinkel
Alan
A
D004594:Electrophysiology; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D017180:Tachycardia, Ventricular / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D014693:Ventricular Fibrillation / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control*