title: Synthesis of 1,2-dithiolane analogues of leucine for potential use in peptide chemistry.
abstract: [reaction: see text]1,2-Dithiolanes present several points of interest for both peptide and medicinal chemistry, yet no chiral alpha-amino acids containing this five-membered heterocyclic system are available. We report here the first synthesis of N- and C-protected derivative of (S)-2-amino-3-(1,2-dithiolan-4-yl)propionic acid (Adp) and its 1,3-dithiolic form.
authors.affiliation: Dipartimento di Studi Farmaceutici and Centro di Studio per la Chimica del Farmaco del CNR, Università degli Studi di Roma "La Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Morera
authors.forename: Francesco
authors.initials: F
authors.lastname: Pinnen
authors.forename: Gino
authors.initials: G
authors.lastname: Lucente
mesh_terms: D007202:Indicators and Reagents; D007930:Leucine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D010455:Peptides / Q000737:chemistry*; D013237:Stereoisomerism; D008063:Thioctic Acid / Q000031:analogs & derivatives / Q000737:chemistry*
chemical_list: C448825:1,2-dithiolane; D007202:Indicators and Reagents; D010455:Peptides; D008063:Thioctic Acid; D007930:Leucine