title: Clinical and radiographic features of a family with autosomal dominant amelogenesis imperfecta with taurodontism.
abstract: This paper describes the clinical features of a family of four generations with autosomal dominant amelogenesis imperfecta with taurodontism (ADAIT). Considerable variation in phenotype was seen, both between individuals and within the dentition of some individuals. Many of the adults had received extensive dental restorative work. These findings re-enforce previous observations of variable phenotype in this and other forms of the condition and add to the argument for a revision of methods of classification. This history of this large family draws further attention to the restorative demands of this group of dental anomalies and, by their generous co-operation, will prove an invaluable help in the investigation by molecular genetic techniques of this disfiguring condition.
authors.affiliation: Department of Dentistry, Royal Children's Hospital, Melbourne, Australia. michael_aldred@bigpond.com
authors.forename: M J
authors.initials: MJ
authors.lastname: Aldred
authors.forename: R
authors.initials: R
authors.lastname: Savarirayan
authors.forename: S R
authors.initials: SR
authors.lastname: Lamandé
authors.forename: P J M
authors.initials: PJ
authors.lastname: Crawford
mesh_terms: D000293:Adolescent; D000328:Adult; D000567:Amelogenesis Imperfecta / Q000145:classification / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D002648:Child; D003782:Dental Pulp / Q000002:abnormalities*; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007180:Incisor / Q000002:abnormalities*; D008297:Male; D009811:Odontometry; D010375:Pedigree; D010641:Phenotype; D011859:Radiography; D014075:Tooth Discoloration / Q000150:complications; D014092:Tooth Root / Q000002:abnormalities; D014739:Victoria