Investigation of cross-resistance between rifampin and rifabutin in Mycobacterium tuberculosis complex strains.
In order to indicate the cross-resistance between rifampin (RMP) and rifabutin (RBU), minimal inhibitory concentrations (MICs) of RBU were investigated in 50 Mycobacterium tuberculosis strains. The MIC values of 25 RMP-susceptible (to 2 microg/ml) and 25 RMP-resistant (to 2 microg/ml) M. tuberculosis strains against RBU were determined by the Bactec TB 460 system. All of the RMP-susceptible strains were also susceptible to RBU (MIC < or = 1 microg/ml). Three out of 25 (12%) RMP-resistant strains were determined as susceptible to RBU. The high level cross-resistance (88%) obtained in this study highlights the importance of testing susceptibility to RBU prior to its inclusion in the tuberculosis treatment regimens at the Istanbul Faculty of Medicine.
Uzun
M
M
Istanbul Faculty of Medicine, Department of Microbiology and Clinical Microbiology, Capa, Turkey. meltemuzuntr@yahoo.com
Erturan
Z
Z
Anğ
O
O
D018432:Drug Resistance, Multiple; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D017828:Rifabutin / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology*; D012680:Sensitivity and Specificity; D014421:Turkey
D017828:Rifabutin; D012293:Rifampin