The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract: friend or foe?
OBJECTIVE
To evaluate the role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract.


METHODS
Prospective study; institutional review board-approved clinical trial.


METHODS
Tertiary care pediatric medical center.


METHODS
Fifteen patients; choanal atresia in 5 patients, airway stenosis in 8 patients, hypopharyngeal stenosis in 1 patient, and esophageal stenosis in 1 patient.


RESULTS
The efficacy and safety of mitomycin in the prevention of scar formation.


METHODS
All patients underwent surgical repair of the stenotic area, followed by topical application of mitomycin (1 mL of 0.4 mg/mL) for 4 minutes.


RESULTS
Ten patients (67%) showed major improvement, 4 patients (27%) showed minor improvement, and 1 patient (7%) showed no improvement.


CONCLUSIONS
Topical application of mitomycin can play an effective role in the prevention and treatment of scar formation in the aerodigestive tract.
Rahbar
Reza
R
Department of Otolaryngology and Communication Disorders, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA. reza.rahbar@tch.harvard.edu
Jones
Dwight T
DT
Nuss
Roger C
RC
Roberson
David W
DW
Kenna
Margaret A
MA
McGill
Trevor J
TJ
Healy
Gerald B
GB
D000287:Administration, Topical; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002754:Choanal Atresia / Q000188:drug therapy / Q000601:surgery; D002921:Cicatrix / Q000517:prevention & control*; D003251:Constriction, Pathologic; D004940:Esophageal Stenosis / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007829:Laryngostenosis / Q000188:drug therapy / Q000601:surgery; D008297:Male; D016685:Mitomycin / Q000494:pharmacology / Q000627:therapeutic use*; D010608:Pharyngeal Diseases / Q000188:drug therapy / Q000601:surgery; D011446:Prospective Studies; D012140:Respiratory Tract Diseases / Q000188:drug therapy* / Q000601:surgery; D015607:Stents; D014135:Tracheal Stenosis / Q000188:drug therapy / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D016685:Mitomycin