High serum hepatocyte growth factor levels in the acute stage of community-acquired infectious diseases.
Acute serum levels of hepatocyte growth factor (HGF) were studied in 6 clinical groups with (i) gastroenteritis, (ii) skin and soft tissue infection, (iii) urinary tract infection, (iv) septicemia, (v) influenza, and (vi) chronic hepatitis C in comparison with a normal control group using an enzyme-linked immunosorbent assay method. We found that serum HGF levels were significantly higher in patients with acute infectious diseases (p < 0.0001) compared to patients with chronic viral hepatitis and healthy controls. Serum HGF and CRP levels were correlated significantly (r=0.65, p < 10(-7)). We conclude that serum HGF levels are elevated in patients with acute infectious diseases.
Nayeri
F
F
Department of Health and Environment, Faculty of Health Science, University Hospital Linköping, Sweden. fariba.nayeri@lio.se
Nilsson
I
I
Brudin
L
L
Fryden
A
A
Söderström
C
C
Forsberg
P
P
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D017714:Community-Acquired Infections / Q000097:blood*; D005260:Female; D005759:Gastroenteritis / Q000097:blood; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D007251:Influenza, Human / Q000097:blood; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000097:blood; D012874:Skin Diseases, Infectious / Q000097:blood; D014552:Urinary Tract Infections / Q000097:blood
D015415:Biomarkers; D017228:Hepatocyte Growth Factor