ICAM-1 in maternal serum and amniotic fluid as an early marker of preeclampsia and IUGR.
OBJECTIVE
To determine if plasma and amniotic fluid levels of intercellular adhesion molecule-1 (ICAM-1) at 16 weeks' gestation could be predictive of preeclampsia or intrauterine growth retardation (IUGR).


METHODS
A retrospective analysis was undertaken in 44 serum samples stored for Down's syndrome screening at 16 weeks' gestation and 44 amniotic fluid samples obtained by midtrimester amniocentesis.


RESULTS
No significant difference was found between women who subsequently developed preeclampsia or IUGR and the control group.


CONCLUSIONS
This study failed to demonstrate that ICAM-1 may be an early serum marker of preeclampsia or an amniotic fluid marker of IUGR.
Baviera
Giovanni
G
Departments of Gynecology and Internal Medicine, University of Messina, Messina, Italy.
D'Anna
Rosario
R
Corrado
Francesco
F
Ruello
Antonella
A
Buemi
Michele
M
Jasonni
Valerio Maria
VM
D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry*; D015415:Biomarkers / Q000032:analysis*; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D012189:Retrospective Studies
D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1