title: Bone mineral density assessment: comparison of dual-energy X-ray absorptiometry measurements at the calcaneus, spine, and hip.
abstract: It is widely accepted that bone mineral density (BMD) measurements obtained by dual-energy X-ray absorptiometry (DXA) at the spine, hip, and calcaneus predict fracture risk. Few published studies to date have examined the relationship between pDXA measurements at the calcaneus to those at the hip and spine. It has been demonstrated that T-score-based criteria cannot be universally applied to all skeletal sites and measurement technologies. Our goal was to define the calcaneal T-score threshold equivalent to low bone mass at the hip or spine. A total of 119 female patients between the ages of 33 and 76 yr of age were recruited at Boston University Medical Center for bone densitometry screening. Bone density measurements were obtained at the calcaneus using the portable Norland Apollo Densitometer (Norland Medical Systems, Fort Atkinson, WI) and at the hip and spine using the Norland Eclipse densitometer. By defining a pDXA T-score < or =-1 as a positive test and DXA scores < or =-1 as the presence of low bone mass, we obtained a specificity of 100% and a sensitivity of 73% (positive predictive value 100% and negative predictive value 80%) in detecting low bone mass at the femoral neck in women over age 65 yr. In women between 40 and 65 yr of age, we obtained a sensitivity of 50% and a specificity of 93% (positive predictive value 93% and negative predictive value 50%) in detecting low bone mass at the femoral neck. In women less than 40 yr of age, we obtained a sensitivity of 13% and a specificity of 100% (positive predictive value 100% and negative predictive value 75%) in detecting low bone mass at the femoral neck. From receiver operating characteristic curves, a calcaneal T-score < or =0.0 detects those with a T-score < or =-1 at the femoral neck and lumbar spine with 100% and 85% sensitivity, respectively. Peripheral DXA of the calcaneus is a sensitive and specific test to diagnose low bone mass in women over 65 yr of age. In women under 65 yr of age, this modality, though not as sensitive, is specific in detecting low bone mass. We conclude that a pDXA calcaneal T-score < or =0 is highly sensitive in predicting osteopenia and osteoporosis at the femoral neck and lumbar spine.
authors.affiliation: Department of Medicine, Division of Endocrinology, St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA.
authors.forename: Ann T
authors.initials: AT
authors.lastname: Sweeney
authors.forename: Alan O
authors.initials: AO
authors.lastname: Malabanan
authors.forename: Michael A
authors.initials: MA
authors.lastname: Blake
authors.forename: Janice
authors.initials: J
authors.lastname: Weinberg
authors.forename: Adrian
authors.initials: A
authors.lastname: Turner
authors.forename: Patricia
authors.initials: P
authors.lastname: Ray
authors.forename: Michael F
authors.initials: MF
authors.lastname: Holick
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000367:Age Factors; D000368:Aged; D015519:Bone Density; D002111:Calcaneus / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010384:Pelvic Bones / Q000502:physiology*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013131:Spine / Q000502:physiology*