Investigation of the larvicidal activity of Pothomorphe peltata and isolation of the active constituent.
The insecticidal activity of the leaves of Pothomorphe peltata (Piperaceae) was evaluated on Aedes aegypti larvae. The active methanol extract was subjected to a bioactivity-directed fractionation, monitored by the larvicidal assay, and led to the isolation of a catechol derivative, 4-nerolidylcatechol. This compound was quite potent against Aedes aegypti larvae (LC(50) = 9.1 microg/mL).
Mongelli
E
E
Cátedra de Farmacognosia, IQUIMEFA-CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113) Buenos Aires, Argentina.
Coussio
J
J
Ciccia
G
G
D000330:Aedes / Q000187:drug effects*; D000818:Animals; D002396:Catechols / Q000494:pharmacology*; D007306:Insecticides / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D026321:Piperaceae; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves
C110583:4-nerolidylcatechol; D002396:Catechols; D007306:Insecticides; D010936:Plant Extracts