title: Correlates of prevalent and incident Kaposi's sarcoma-associated herpesvirus infection in men who have sex with men.
abstract: Infection with Kaposi's sarcoma-associated herpesvirus (KSHV) is common among men who have sex with men (MSM). To determine correlates of infection, 578 human immunodeficiency virus (HIV)-negative MSM were assessed by serologic assays, questionnaires, and physical examinations. At baseline, 76 (16%) of 474 participants were KSHV seropositive. Prevalent KSHV infection was significantly associated with hepatitis A (odds ratio [OR], 3.3; 95% confidence interval [CI], 1.5-7.5), hepatitis B seropositivity (OR, 2.6; 95% CI, 1.4-4.8), herpes simplex virus (HSV)-2 (OR, 2.4; 95% CI, 1.3-4.4), and >4 male partners in the previous 6 months (OR, 1.9; 95% CI, 1.1-3.2). Fifteen KSHV seroconversions (4%) were observed for an incidence of 3.8/100 person-years, similar to HSV-1 incidence in this cohort and more frequent than incidence of HIV and HSV-2. Reporting > or =1 HIV-positive partner (OR, 5.9; 95% CI, 1.8-19.3), amyl nitrite use (OR, 7.0; 95% CI, 2.1-23.0), and lymphadenopathy in the past 6 months (OR, 7.7; 95% CI, 1.9-31.0) correlated with KSHV seroconversion.
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA 98195, USA. ccasper@u.washington.edu
authors.forename: Corey
authors.initials: C
authors.lastname: Casper
authors.forename: Anna
authors.initials: A
authors.lastname: Wald
authors.forename: John
authors.initials: J
authors.lastname: Pauk
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Tabet
authors.forename: Lawrence
authors.initials: L
authors.lastname: Corey
authors.forename: Connie L
authors.initials: CL
authors.lastname: Celum
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D015331:Cohort Studies; D018023:HIV Seronegativity; D006561:Herpes Simplex / Q000453:epidemiology; D006566:Herpesviridae Infections / Q000453:epidemiology*; D018259:Herpesvirus 1, Human / Q000276:immunology; D018258:Herpesvirus 2, Human / Q000276:immunology; D019288:Herpesvirus 8, Human / Q000276:immunology; D018451:Homosexuality, Male; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D016036:Seroepidemiologic Studies; D012747:Sexual Partners; D015229:Sexually Transmitted Diseases, Viral / Q000453:epidemiology / Q000821:virology; D011795:Surveys and Questionnaires
chemical_list: D000914:Antibodies, Viral