title: [A patient with advanced gastric cancer in the gastric tube whose QOL was improved by TS-1].
abstract: We present the case of a 72-year-old man with gastric tube cancer accompanied by multiple liver metastases, after esophagectomy for esophageal cancer, whose quality of life (QOL) was improved with a small dosage of TS-1. The patient's high serum AFP level suggested alpha-fetoprotein-producing gastric cancer. He was treated with half the standard dose of TS-1, because the patient's poor general condition necessitated chemotherapy with low toxicity and high efficacy. The daily dose was 40 mg for the first three courses and 50 mg for the last two. Each treatment course consisted of a four-week administration followed by two drug-free weeks. The patient received five courses of chemotherapy at our outpatient clinic before his death from re-progression of liver metastasis. No serious side effect except temporary stomatitis was observed. A decrease in tumor markers, alpha-fetoprotein and carcinoembryonic antigen, was obtained after 4 weeks. After 2 cycles, computed tomography and endoscopy examinations showed regression of the primary tumor and liver metastases, and tumor markers were decreased remarkably. The patient's QOL improved gradually after the treatment. His performance status before the chemotherapy was 3, and improved to 1 after two cycles. The small dosage of TS-1 was effective without any adverse effects, and improved the patient's QOL, for 6 months.
authors.affiliation: Dept. of Surgery, Toyama Prefectural Central Hospital.
authors.forename: Hideto
authors.initials: H
authors.lastname: Fujita
authors.forename: Isaku
authors.initials: I
authors.lastname: Yoshioka
authors.forename: Masafumi
authors.initials: M
authors.lastname: Inokuchi
authors.forename: Keiko
authors.initials: K
authors.lastname: Iwata
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ajisaka
authors.forename: Seiichi
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Masahide
authors.initials: M
authors.lastname: Kaji
authors.forename: Kiichi
authors.initials: K
authors.lastname: Maeda
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Yabushita
authors.forename: Kohji
authors.initials: K
authors.lastname: Konishi
authors.forename: Atsuo
authors.initials: A
authors.lastname: Miwa
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000523:psychology / Q000556:secondary; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000523:psychology; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid