title: Eosinophilic leukemia associated with t(2;5)(p23;q31).
abstract: Chromosomal aberrations have been reported in most malignant hematopoietic disorders such as acute or chronic myeloid leukemia, acute lymphoid leukemia, and myelodysplastic syndromes. Eosinophilic leukemia is a rare hematologic malignancy difficult to distinguish from other forms of idiopathic hypereosinophilic syndrome, so that the diagnosis is often made by exclusion, unless cytogenetic abnormalities can be demonstrated in bone marrow cells. We describe a patient with eosinophilic leukemia whose cytogenetic study shows a t(2;5)(p23;q31). Initial data could suggest a clonal eosinophilia, with an hepatosplenomegaly, severe pancytopenia, and a high level of blood and medullar eosinophilia.
authors.affiliation: Department of Haematology, Centre Henri Becquerel, Rue d'Amiens, 76038 Rouen Cedex, France. slepretre@rouen.fnclcc.fr
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lepretre
authors.forename: Fabrice
authors.initials: F
authors.lastname: Jardin
authors.forename: Gérard
authors.initials: G
authors.lastname: Buchonnet
authors.forename: Pascal
authors.initials: P
authors.lastname: Lenain
authors.forename: Aspasia
authors.initials: A
authors.lastname: Stamatoullas
authors.forename: Ingrid
authors.initials: I
authors.lastname: Kupfer
authors.forename: Philippe
authors.initials: P
authors.lastname: Courville
authors.forename: Marie Paule
authors.initials: MP
authors.lastname: Callat
authors.forename: Nathalie
authors.initials: N
authors.lastname: Contentin
authors.forename: Christian
authors.initials: C
authors.lastname: Bastard
authors.forename: Hervé
authors.initials: H
authors.lastname: Tilly
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D004804:Eosinophils / Q000473:pathology*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000235:genetics* / Q000473:pathology; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic