Nuclear envelope: torn apart at mitosis.
The findings of two recent studies suggest a novel mechanism for nuclear envelope breakdown in which cytoplasmic dynein anchored on the outside of the nucleus generates tension, thus triggering tearing of the nuclear envelope.
Gönczy
Pierre
P
ISREC (Swiss Institute for Experimental Cancer Research), 155, ch. des Boveresses, CH-1066, Epalinges/Lausanne, Switzerland. Pierre.Gonczy@isrec.unil.ch
D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism; D000072159:Dynactin Complex; D004398:Dyneins / Q000378:metabolism*; D006801:Humans; D034882:Lamins; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism / Q000502:physiology; D008938:Mitosis / Q000502:physiology*; D009685:Nuclear Envelope / Q000378:metabolism / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism*
D000072159:Dynactin Complex; D034882:Lamins; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; D016203:CDC2 Protein Kinase; D004398:Dyneins