title: Intermittent vagal nerve stimulation in paediatric patients: 1-year follow-up.
abstract: OBJECTIVE
  Vagal nerve stimulation (VNS) has recently been proposed as a valid treatment for adult patients with drug-resistant partial epilepsy. Little experience in children has been reported. In order to evaluate the clinical efficacy and tolerance of VNS, we studied 13 paediatric patients with drug-resistant partial epilepsy.
  
  
  METHODS
  Improvement in seizure frequency was estimated by calculating the percentage of change in seizure frequency during each 3-month period following initiation of VNS, compared with the 3-month period prior to the implantation of the VNS device. The improvement in quality of life (QOL) was evaluated with the Vineland Behavior Adaptive Scale (VBAS).
  
  
  RESULTS
  In all patients, the surgical procedure was well tolerated. A recent modification of the implantation technique needing only a single cervical incision, has further reduced the aesthetic damage, particularly in small children who have a reduced muscular mass. Three months after the surgical procedure, 10 of the 13 patients demonstrated a seizure reduction rate greater than 50%. At the 1-year follow-up these positive results were maintained: 6 out of 8 patients continued to demonstrate a seizure reduction rate greater than 50%. Comparison with the pre-implantation period also showed a significant improvement in QOL in 4 out of 8 patients. We conclude that VNS is a valid treatment modality in children with drug-resistant partial epilepsy.
authors.affiliation: Paediatric Neurology Department, Children's Hospital G. Salesi, Via Corridoni 11, 60122 Ancona, Italy. npisalesi@libero.it
authors.forename: Nelia
authors.initials: N
authors.lastname: Zamponi
authors.forename: Franco
authors.initials: F
authors.lastname: Rychlicki
authors.forename: Cesare
authors.initials: C
authors.lastname: Cardinali
authors.forename: Anna
authors.initials: A
authors.lastname: Luchetti
authors.forename: Roberto
authors.initials: R
authors.lastname: Trignani
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ducati
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance; D004599:Electric Stimulation Therapy / Q000009:adverse effects; D004828:Epilepsies, Partial / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011788:Quality of Life; D014630:Vagus Nerve / Q000503:physiopathology*
chemical_list: D000927:Anticonvulsants