title: Bisphosphonate chelating agents. Coordination ability of 1-phenyl-1-hydroxymethylene bisphosphonate towards Cu(2+) ions.
abstract: Potentiometric and EPR data allow for evaluation of the coordination equilibria in the Cu(2+)-bisphosphonate system. The bisphosphonic ligand was found very efficient in Cu(2+) chelation with formation of monomeric and dimeric species. Two phosphonate groups are basic binding sites for metal ion. The involvement of hydroxyl in metal ion coordination is also likely, especially when one phosphonate is protected by dimethyl ester. As the metal bound phosphonate groups are relatively bulky (six oxygens) and their negative charge above pH 4 is high (four per ligand) the equimolar species is a dominant complex at physiological pH.
authors.affiliation: Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383, Wroclaw, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Gumienna-Kontecka
authors.forename: Julia
authors.initials: J
authors.lastname: Jezierska
authors.forename: Marc
authors.initials: M
authors.lastname: Lecouvey
authors.forename: Yves
authors.initials: Y
authors.lastname: Leroux
authors.forename: Henryk
authors.initials: H
authors.lastname: Kozlowski
mesh_terms: D002413:Cations, Divalent / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004164:Diphosphonates / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D008968:Molecular Conformation; D011199:Potentiometry; D011522:Protons
chemical_list: D002413:Cations, Divalent; D002614:Chelating Agents; D004164:Diphosphonates; D011522:Protons; D003300:Copper