title: Cyanoacrylate medical adhesives--a new era Colgate ORABASE Soothe.N.Seal Liquid Protectant for canker sore relief.
abstract: Cyanoacrylate, a synthetic adhesive, is a fast polymerizable liquid monomer. Serendipity led to the discovery of cyanoacrylate adhesives in 1951. Today, a specific cyanoacrylate monomer, 2-octyl cyanoacrylate, is being used in a topical medical adhesive formulation. The only over-the-counter cyanoacrylate-based product cleared by the Food and Drug Administration is Colgate ORABASE Soothe.N. Seal Liquid Protectant. Upon application, this liquid monomer formulation polymerizes instantly into a thin, flexible polymer film that adheres tenaciously to mucosal tissue. This polymer film creates a mechanical barrier that provides immediate and long-term pain relief of oral ulcerations and irritations, and maintains a natural healing environment for the area to heal.
authors.affiliation: Closure Medical Corporation, Raleigh, North Carolina, USA.
authors.forename: U
authors.initials: U
authors.lastname: Narang
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D002266:Carboxymethylcellulose Sodium / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D003487:Cyanoacrylates / Q000737:chemistry / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000627:therapeutic use; D006801:Humans; D022125:Lacerations / Q000188:drug therapy; D020011:Protective Agents / Q000627:therapeutic use*; D013281:Stomatitis, Aphthous / Q000188:drug therapy*; D014014:Tissue Adhesives / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D003487:Cyanoacrylates; D003879:Dermatologic Agents; D020011:Protective Agents; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate; C056627:Orabase; D002266:Carboxymethylcellulose Sodium