title: Central nociceptive role of prostacyclin (IP) receptor induced by peripheral inflammation.
abstract: Prostacyclin (PGI2) is well known to play crucial roles in induction of edema and pain behavior in the periphery. In the present study, we investigated the central role of PGI2 in inflammatory pain. Intraplantar injection of carrageenan markedly induced the expression of prostacyclin receptor (IP receptor) mRNA with the maximum at 6 h, coincidently induction of the inducible form of cyclooxygenase (COX-2), although IP receptor mRNA was weakly expressed in the spinal cord of naive mice. Intrathecal administration of the IP agonist cicaprost induced mechanical hyperalgesia 6 h after carrageenan injection. These results suggest that PGI2 is involved in pain transmission at the spinal cord following expression of IP receptor mRNA induced by peripheral inflammation.
authors.affiliation: Department of Anesthesiology, Osaka Medical College, Takatsuki, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Doi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Minami
authors.forename: Mikio
authors.initials: M
authors.lastname: Nishizawa
authors.forename: Tamaki
authors.initials: T
authors.lastname: Mabuchi
authors.forename: Hidemaro
authors.initials: H
authors.lastname: Mori
authors.forename: Seiji
authors.initials: S
authors.lastname: Ito
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D002351:Carrageenan; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006614:Hindlimb; D006930:Hyperalgesia / Q000139:chemically induced / Q000503:physiopathology; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D051379:Mice; D009619:Nociceptors / Q000503:physiopathology*; D017288:Pain Threshold / Q000187:drug effects; D010812:Physical Stimulation; D012333:RNA, Messenger / Q000378:metabolism; D044006:Receptors, Epoprostenol; D011982:Receptors, Prostaglandin / Q000235:genetics / Q000502:physiology*; D012016:Reference Values; D013997:Time Factors
chemical_list: D012333:RNA, Messenger; D044006:Receptors, Epoprostenol; D011982:Receptors, Prostaglandin; D002351:Carrageenan; D011464:Epoprostenol; C043867:cicaprost