title: Computer-aided ventilator resetting is feasible on the basis of a physiological profile.
abstract: BACKGROUND
  Ventilator resetting is frequently needed to adjust tidal volume, pressure and gas exchange. The system comprising lungs and ventilator is so complex that a trial and error strategy is often applied. Comprehensive characterization of lung physiology is feasible by monitoring. The hypothesis that the effect of ventilator resetting could be predicted by computer simulation based on a physiological profile was tested in healthy pigs.
  
  
  METHODS
  Flow, pressure and CO2 signals were recorded in 7 ventilated pigs. Elastic recoil pressure was measured at postinspiratory and post-expiratory pauses. Inspiratory and expiratory resistance as a function of volume and compliance were calculated. CO2 elimination per breath was expressed as a function of tidal volume. Calculating pressure and flow moment by moment simulated the effect of ventilator action, when respiratory rate was varied between 10 and 30 min(-1) and minute volume was changed so as to maintain PaCO2. Predicted values of peak airway pressure, plateau pressure, and CO2 elimination were compared to values measured after resetting.
  
  
  RESULTS
  With 95% confidence, predicted pressures and CO2 elimination deviated from measured values with < 1 cm H2O and < 6%, respectively.
  
  
  CONCLUSIONS
  It is feasible to predict effects of ventilator resetting on the basis of a physiological profile at least in health.
authors.affiliation: Department of Clinical Physiology, University Hospital, Lund, Sweden. leif.uttman@klinfys.lu.se
authors.forename: L
authors.initials: L
authors.lastname: Uttman
authors.forename: B
authors.initials: B
authors.lastname: Jonson
mesh_terms: D000403:Airway Resistance; D000758:Anesthesia; D000818:Animals; D001944:Breath Tests; D002245:Carbon Dioxide / Q000032:analysis; D003198:Computer Simulation; D006801:Humans; D008170:Lung Compliance; D012121:Respiration, Artificial; D015656:Respiratory Mechanics; D012815:Signal Processing, Computer-Assisted; D013552:Swine; D013813:Therapy, Computer-Assisted; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide