Whole-pulmonary low-dose radiation therapy in agnogenic myeloid metaplasia with diffuse lung involvement.
Agnogenic myeloid metaplasia is a hematologic disorder accompanied by extramedullary hematopoiesis (EMH) affecting various organs. Lung involvement however is rare. We present the case of a 76-year-old woman with myelofibrosis, recurrent pleural effusions, pulmonary hypertension, and serious right cardiac failure. An open lung biopsy confirmed pulmonary EMH. She underwent low-dose (200 cGy) whole-lung radiotherapy in 4 fractions of 50 cGy each. Her clinical and hemodynamic parameters improved. We conclude that low-dose whole-lung radiation may be efficacious for the palliative treatment of pulmonary EMH.
Weinschenker
Patrícia
P
Division of Hematology and Oncology, ABC Foundation School of Medicine, São Paulo, Brazil.
Kutner
José M
JM
Salvajoli
João V
JV
Hanriot
Rodrigo M
RM
Ribeiro
Andressa F
AF
Capelozzi
Vera L
VL
Del Giglio
Auro
A
D000368:Aged; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D006976:Hypertension, Pulmonary; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy*; D010166:Palliative Care; D010996:Pleural Effusion; D055728:Primary Myelofibrosis / Q000473:pathology / Q000503:physiopathology*