title: Gentamicin PMMA beads and other local antibiotic carriers in two-stage revision of total knee infection: a review.
abstract: Local antibiotic carriers are available as resorbable carriers (e.g. gentamicin-loaded collagen) and non resorbable carriers, mostly gentamicin-loaded bone cement in the form of beads or spacers. The release of the antibiotic may differ largely, depending on the properties of the carrier. In the use of spacers the release may remain too low, resulting in subinhibitory gentamicin concentrations. Revision of late deep infection of a knee prosthesis includes extraction, debridement and the use of local and systemic antibiotics. Reimplantation can be performed if healing is appropriate and the bone stock reaches. Otherwise arthrodesis is necessary.
authors.affiliation: Department of Orthopedic Surgery, Academic Hospital, Maastricht, The Netherlands. gwa@sort.azm.nl
authors.forename: G H
authors.initials: GH
authors.lastname: Walenkamp
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004337:Drug Carriers; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects; D008863:Microspheres; D019904:Polymethyl Methacrylate; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery*; D012086:Reoperation
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D005839:Gentamicins; D019904:Polymethyl Methacrylate