[Two single nucleotide polymorphisms of beta 2-adrenoceptor gene in elderly patients with hypertension].
OBJECTIVE
To investigate the association of two single nucleotide polymorphisms (SNPs) of beta 2-adrenoceptor (beta 2-AR) gene with hypertension in elderly patients.


METHODS
The study samples were collected from unrelated Chinese Han population of Dabie Mountain in Anhui province. Eighty-six elderly patients with hypertension and 43 controls were selected. Genotypes of +1053 and +1239 SNPs were typed by polymerase chain reaction-restriction fragment length polymorphism.


RESULTS
The frequencies of the two SNPs complied well with the Hardy-Weinberg equilibrium in normal group. The distribution of genotypes AA, GA,GG of the SNP at locus +1239 in moderate and severe hypertension group was significantly different from that in normal group (chi square=8.67, P<0.05). There were evident differences in the frequencies of alleles of the two groups (chi square=4.02, P<0.05). No significant difference was observed in the distribution of genotypes of the SNP at locus +1053 between the two groups.


CONCLUSIONS
These data indicate that the SNP at locus +1239 of beta 2-AR gene is associated with hypertension in elderly patients.
Wu
Hong
H
Institute of Genetics, Fudan University, Shanghai, 200433 P. R. China. everwh@sina.com
Song
Xiufeng
X
Xiao
Junhua
J
Hu
Fang
F
Huang
Wei
W
Lu
Daru
D
Xue
Jinglun
J
Jin
Li
L
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
D018343:Receptors, Adrenergic, beta-2; D004247:DNA