Perivascular myoma: case report with immunohistochemical and ultrastructural studies.
A subcutaneous myopericytoma-type perivascular myoma arising in the elbow of a 61-year-old woman is described. The tumor was well demarcated and consisted microscopically of small ovoid and spindle cells arranged in a concentric fashion, surrounding small to medium-sized vessels and imparting a superficial resemblance to hemangiopericytoma. In some areas, the cellular whorls were separated by myxoid stroma. Cells located between cellular whorls appeared immature with scant cytoplasm but did not show distinct nuclear anaplasia, increased mitoses or foci of necrosis. Immunohistochemistry showed that constituent cells were positive for alpha-smooth muscle actin and desmin. Electron microscopy disclosed that the immature-looking cells, as well as the ovoid and spindle-shaped cells, possessed focal densities along with thin filaments, subplasmalemmal densities, pinocytotic vesicles and an external lamina. These ultrastructural and immunohistochemical features indicate a myoid nature of pericytic cells and justify this type of neoplasm being categorized as perivascular myoid tumor.
Mikami
Yoshiki
Y
Department of Pathology, Kawasaki Medical School Hospital, Kurashiki, Okayama, Japan. mika@med.kawasaki-m.ac.jp
Shiomi
Tatsushi
T
Manabe
Toshiaki
T
D000199:Actins / Q000032:analysis; D003893:Desmin / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008875:Middle Aged; D009130:Muscle, Smooth / Q000737:chemistry; D009214:Myoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D019043:Vascular Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
D000199:Actins; D003893:Desmin