title: Becker muscular dystrophy-related cardiomyopathy: a favorable response to medical therapy.
abstract: Patients with Becker muscular dystrophy-related cardiomyopathy typically survive into their 30s, when they succumb to complications of cardiomyopathy or receive heart transplants. The cardiomyopathy is related to an abnormality in the protein dystrophin; no successful medical responses have been reported to date. We describe a patient with Becker muscular dystrophy-related cardiomyopathy in whom we noted improvement of cardiac status with carefully titrated medical therapy. Successful therapy suggests a trial of medical therapy may be beneficial when patients with Becker muscular dystrophy-related cardiomyopathy are evaluated for transplant.
authors.affiliation: Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.
authors.forename: Anthony H
authors.initials: AH
authors.lastname: Doing
authors.forename: Dale G
authors.initials: DG
authors.lastname: Renlund
authors.forename: Ruth Ann
authors.initials: RA
authors.lastname: Smith
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use; D002227:Carbazoles / Q000627:therapeutic use; D009202:Cardiomyopathies / Q000188:drug therapy / Q000209:etiology*; D000077261:Carvedilol; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000150:complications* / Q000188:drug therapy; D011412:Propanolamines / Q000627:therapeutic use; D013318:Stroke Volume / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D002216:Captopril