title: Apathetic Graves' disease and acquired hemophilia due to factor VIIIc antibody.
abstract: Acquired hemophilia due to autoantibody to Factor VIII coagulant (Factor VIIIc) is a rare event which may be observed in patients with different autoimmune diseases. To our knowledge, this association has been reported only once in patients with autoimmune thyroid disease. Here we describe a patient presenting with a severe hemorrhagic disorder due to Factor VIIIc antibody in whom biochemical screening for thyroid diseases led to a diagnosis of hyperthyroid Graves' disease not associated to overt clinical features. This case underlines the importance of carrying out a complete screening for autoimmunity, including thyroid autoimmune disease, in all patients with apparently isolated serum Factor VIIIc inhibitors.
authors.affiliation: Centre for Hemostasis and Endocrinology Unit, Department of Medical Sciences M. Aresu University of Cagliari, Italy. marongiu@pacs.unica.it
authors.forename: F
authors.initials: F
authors.lastname: Marongiu
authors.forename: C
authors.initials: C
authors.lastname: Cauli
authors.forename: G
authors.initials: G
authors.lastname: Mameli
authors.forename: B
authors.initials: B
authors.lastname: Usai
authors.forename: S
authors.initials: S
authors.lastname: Mariotti
mesh_terms: D013956:Antithyroid Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000276:immunology*; D005169:Factor VIII / Q000276:immunology*; D005260:Female; D006111:Graves Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*; D006417:Hematuria / Q000276:immunology; D006465:Hemoperitoneum / Q000276:immunology; D006467:Hemophilia A / Q000276:immunology*; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000601:surgery; D008713:Methimazole / Q000627:therapeutic use; D008875:Middle Aged; D010052:Ovariectomy; D019106:Postoperative Hemorrhage / Q000276:immunology; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D014594:Uterine Neoplasms / Q000601:surgery
chemical_list: D013956:Antithyroid Agents; D001323:Autoantibodies; D013963:Thyroid Hormones; D008713:Methimazole; D005169:Factor VIII; D013972:Thyrotropin