The effects of immunization against cholecystokinin fragment 30-33 in the behavior of white rats.
Active immunization of white rats with cholecystokinin-4 covalently linked to the antigen carrier BSA evoked long-lasting changes in the rats' behavior, which were in the opposite direction to the anxiogenic effects of cholecystokinin-4 itself, showing that immunization had anxiolytic effects. Immunoenzyme analysis demonstrated the presence of antibodies to cholecystokinin-4 in the serum of immunized rats. These data are interesting from the point of view of correcting pathological anxiety and fear states by inverse immunoregulation.
Danilova
R A
RA
M. V. Lomonosov Moscow State University, Russia.
Rud'ko
O I
OI
Korotkova
T M
TM
Obukhova
M F
MF
Ashmarin
I P
IP
D000428:Alcohol Drinking / Q000276:immunology; D000818:Animals; D001007:Anxiety / Q000276:immunology* / Q000503:physiopathology; D001522:Behavior, Animal / Q000502:physiology*; D003216:Conditioning, Operant / Q000187:drug effects; D003863:Depression / Q000523:psychology; D005106:Exploratory Behavior / Q000502:physiology; D005239:Fear / Q000502:physiology; D007124:Immunoenzyme Techniques; D008297:Male; D009043:Motor Activity / Q000502:physiology; D010147:Pain Measurement / Q000187:drug effects; D010446:Peptide Fragments / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000523:psychology; D013758:Tetragastrin / Q000276:immunology*
D010446:Peptide Fragments; D013758:Tetragastrin