title: Do Opioid, alpha(2)-Adrenoreceptors, or Benzodiazepine Receptors Mediate ECS-Induced Hypothermia in Mice?
abstract: A single electroconvulsive shock in TO mice produced a drop in body temperature of 1.5-2 degrees C, which was maintained for up to 60 min. This hypothermic response was not attenuated by the opioid antagonist i.p. naltrexone (0.3, 1 mg/kg); the alpha(2)-adrenoreceptor antagonist i.p. RX811059 (0.05, 0.5 mg/kg), or the benzodiazepine receptor antagonist i.p. Ro 15-1788 (10, 20 mg/kg). The doses of antagonist used in this study had no effects on body temperature by themselves but significantly attenuated the hypothermia induced by their respective agonists, confirming their receptor-blocking activity. These findings suggest that electroconvulsive shock-induced hypothermia is not mediated by the release of either noradrenaline or by an endogenous ligand acting at opioid or benzodiazepine receptors.
authors.affiliation: Reckitt and Colman Psychopharmacology Unit, Department of Pharmacology, School of Medical Sciences, University Walk, Bristol, England.
authors.forename: Helen C.
authors.initials: HC
authors.lastname: Jackson
authors.forename: Paul J.
authors.initials: PJ
authors.lastname: Weinberger
authors.forename: David J.
authors.initials: DJ
authors.lastname: Nutt