title: 5HTR2A gene polymorphism and personality traits in patients with major psychoses.
abstract: Serotonin receptor (5HTR2A) gene polymorphism has been reported to be associated with clinical phenotypes in schizophrenia. The current study attempted to investigate a relationship between 5HTR2A 102T/C polymorphism and personality traits as well as clinical symptoms in patients with ICD-10 diagnoses of schizophrenia and affective disorders. 5HTR2A genotyping, clinical and psychological assessment were administered to 375 patients, 104 first-degree healthy relatives of the patients and 157 controls. In the patients an association was observed between the 2/2 5HTR2A genotype and scores on the Hypochondriasis scale (MMPI) (ANOVA, F = 4.56; P = 0.011) and trait anxiety (F = 4.21; P = 0.002). A significant difference between 1/1 and 2/2 genotypes has been also found for Neuroticism scores (EPI) (t = 2.18; P = 0.0031). No significant differences by 5HTR2A genotype were observed in either the control or first-degree relatives group for all scales studied. Positive, negative and psychopathological symptoms emerged higher in the 2/2 genotype patients compared to other genotype carriers. Therefore, the 2/2 genotype may contribute to produce the phenotype, with specific clinical and pathological features in common, regardless of nosologic heterogeneity of psychoses.
authors.affiliation: Laboratory of Preventive Genetics, Research Mental Health Center, Russian Academy of Medical Sciences, Zagorodnoe sh. 2/2, Moscow, Russia 113152. golimbet@mail.ru
authors.forename: V E
authors.initials: VE
authors.lastname: Golimbet
authors.forename: M V
authors.initials: MV
authors.lastname: Alfimova
authors.forename: K K
authors.initials: KK
authors.lastname: Manandyan
authors.forename: N G
authors.initials: NG
authors.lastname: Mitushina
authors.forename: L I
authors.initials: LI
authors.lastname: Abramova
authors.forename: V G
authors.initials: VG
authors.lastname: Kaleda
authors.forename: I V
authors.initials: IV
authors.lastname: Oleichik
authors.forename: YuB
authors.initials: Y
authors.lastname: Yurov
authors.forename: V I
authors.initials: VI
authors.lastname: Trubnikov
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D008297:Male; D009031:Moscow; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory; D011110:Polymorphism, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000235:genetics*; D011985:Receptors, Serotonin / Q000235:genetics*
chemical_list: D011985:Receptors, Serotonin