title: Treatment of periodic limb movements in sleep with selegiline HCl.
abstract: Thirty-one patients undergoing treatment with selegiline HCl for periodic limb movements in sleep (PLMS) were examined with respect to specific sleep composition in a retrospective study. Pre- and post-treatment overnight polysomnographs revealed a highly significant decrease in the number of PLMS per hour of total sleep time (P < 0.0005). The alerting effect associated with selegiline was not found to have significant effect on patients' sleep efficiency or sleep-onset latency (P > 0.10). As controversy continues regarding the medicated treatment of PLMS, our findings with selegiline point to an alternative for clinicians to consider.
authors.affiliation: Department of Psychiatry, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
authors.forename: Manavdeep
authors.initials: M
authors.lastname: Grewal
authors.forename: Raed
authors.initials: R
authors.lastname: Hawa
authors.forename: Colin
authors.initials: C
authors.lastname: Shapiro
mesh_terms: D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012148:Restless Legs Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D012642:Selegiline / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D012642:Selegiline