title: Cytokinesis in budding yeast: the relationship between actomyosin ring function and septum formation.
abstract: Cytokinesis in budding yeast is accomplished by the concerted action of actomyosin ring function and septum formation. The actomyosin ring is not essential for cell viability, but it is required for efficient cell division. Deletion of the actomyosin ring results in abnormal septum formation, and a delay in cytokinesis and cell separation. In contrast, septum formation is essential for cell viability. Block of septum formation prevents the contraction, but not the formation of the actomyosin ring. Here we review and provide additional evidence that defines the functional and molecular relationship between actomyosin ring function and septum formation.
authors.affiliation: Department of Cell & Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia 19104-6058, USA. ebi@mail.med.upenn.edu
authors.forename: E
authors.initials: E
authors.lastname: Bi
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D002455:Cell Division; D002473:Cell Wall / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D008954:Models, Biological; D009218:Myosins / Q000378:metabolism*; D004718:Saccharomycetales / Q000166:cytology* / Q000502:physiology; D020703:ras GTPase-Activating Proteins
chemical_list: D000199:Actins; D005656:Fungal Proteins; C101203:IQ motif containing GTPase activating protein 1; D008840:Microfilament Proteins; D020703:ras GTPase-Activating Proteins; D009218:Myosins