title: The need for routine adrenalectomy during surgical treatment for renal cell cancer: the Hannover experience.
abstract: OBJECTIVE
  To further clarify the need for routine adrenalectomy during the surgical treatment of renal cell cancer, as in the absence of clinically overt metastatic disease, tumorous lesions within the adrenal gland are found in only 2-10% of patients, with most being over-treated by adrenalectomy.
  
  
  METHODS
  The medical records of 819 patients undergoing adrenalectomy combined with nephrectomy, irrespective of the local extension of the primary tumour or the clinical stage at first diagnosis, were reviewed to determine the reliability of currently available imaging methods in predicting adrenal gland metastases. Several patient and tumour characteristics were correlated with the presence of intra-adrenal metastases, and their possible independent prognostic value was determined by a multivariate logistic regression model.
  
  
  RESULTS
  There was metastatic spread into the adrenal gland in 27 of 819 (3.3%) patients. In only three of eight patients in whom the adrenal was identified as the only metastatic site were preoperative abdominal computed tomography scans interpreted as false-negative. On multivariate statistical analysis only the presence of distant metastases, vascular invasion within the primary tumour and multifocal growth of renal cell cancer within the tumour-bearing kidney were identified as independent predictors of the presence of intra-adrenal metastases.
  
  
  CONCLUSIONS
  None of the patient or tumour characteristics evaluated reliably predicted the likelihood of adrenal metastases in patients with no evidence of disseminated metastatic spread. However, previously published data indicate that the frequency of metachronous metastases within the contralateral kidney (1.8-3.8%) is significantly higher than the risk of a preoperatively undetected isolated intra-adrenal metastatic lesion when currently available imaging modalities are applied. Therefore, routine adrenalectomy should not be recommended if the preoperative radiological examinations are normal.
authors.affiliation: Department of Urology, Hannover University Medical School, Hannover, Germany. kuczyk.markus@mh-hannover.de
authors.forename: M
authors.initials: M
authors.lastname: Kuczyk
authors.forename: T
authors.initials: T
authors.lastname: Münch
authors.forename: S
authors.initials: S
authors.lastname: Machtens
authors.forename: C
authors.initials: C
authors.lastname: Bokemeyer
authors.forename: A
authors.initials: A
authors.lastname: Wefer
authors.forename: J
authors.initials: J
authors.lastname: Hartmann
authors.forename: C
authors.initials: C
authors.lastname: Kollmannsberger
authors.forename: M
authors.initials: M
authors.lastname: Kondo
authors.forename: U
authors.initials: U
authors.lastname: Jonas
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000556:secondary* / Q000601:surgery; D000315:Adrenalectomy / Q000379:methods*; D002292:Carcinoma, Renal Cell / Q000601:surgery*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000601:surgery*; D016015:Logistic Models; D008297:Male; D011379:Prognosis; D012044:Regression Analysis