Vaccinology for control of apicomplexan parasites: a simplified language of immune programming and its use in vaccine design.
Most mammalian immune systems and parasites have co-evolved over the millennia, interacting within a common environment and communicating through a common language. This language is comprised of copious dialects in which a variety of host innate and acquired immune pathways actively interact with a multitude of parasite-specific survival strategies. Nonetheless, a simplified language is likely present since the same basic molecular and cellular mechanisms are associated with resistance or susceptibility to parasite infection. Protective immunity against protozoa within the phylum Apicomplexa (e.g. Cryptosporidia, Eimeria, Neospora, Plasmodia and Toxoplasma) is generally CD4+ T cell-dependent and elicited along the IL-12/IFN-gamma/iNOS effector axis. This simplified language can be decoded in part by significant advances in understanding naïve T cell activation, differentiation and generation of immunologic memory. Vaccine adjuvants and new immunisation strategies for generation of more potent immunity can also be viewed through this common language lens. The aim of this paper is to summarise recently published fundamental immunology studies, their relevance through examples in specific coccidian-host immune dialects, and how this simplified language can be used for the more rationale design of parasite vaccine control strategies.
Brake
David A
DA
Veterinary Medicine Biological Discovery, Pfizer Global Research and Development, Pfizer Inc., MS 8118-C2, Groton, CT 06340, USA. david_brake@groton.pfizer.com
D000276:Adjuvants, Immunologic; D000818:Animals; D016782:Apicomplexa / Q000276:immunology*; D015195:Drug Design; D006801:Humans; D007156:Immunologic Memory; D051379:Mice; D011528:Protozoan Infections / Q000276:immunology / Q000517:prevention & control*; D016052:Protozoan Vaccines / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D016052:Protozoan Vaccines