Coma probably induced by lorazepam-valproate interaction.
Both valproate (VPA) and lorazepam (LZP) are primarily cleared from the body by glucuronidation. Concomitant administration of VPA has been reported to reduce the elimination of LZP. However, it remains unknown whether this drug interaction is clinically significant. We report a patient with epilepsy who showed that VPA-LZP interaction could result in severe encephalopathy such as coma.
Lee
Sang-Ahm
SA
Department of Neurology and Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. salee@www.amc.seoul.kr
Lee
Jung Kyo
JK
Heo
Kyoung
K
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000097:blood; D003128:Coma / Q000139:chemically induced*; D004347:Drug Interactions / Q000502:physiology; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000009:adverse effects* / Q000097:blood; D014635:Valproic Acid / Q000009:adverse effects* / Q000097:blood
D000927:Anticonvulsants; D014635:Valproic Acid; D008140:Lorazepam