[Diminution of the in vitro and in vivo alloreactive response by association of mature dendritic cells and anti-CD4 monoclonal antibodies in the rat].
Using a fully mismatched model recipient Lewis-donor Wistar-Furth rats, we showed that the association donor mature (spleen) dendritic cells with a non depleting anti-CD4 monoclonal antibody can induce a more pronounced decrease of alloreactivity in mixed splenocyte reaction than anti-CD4 alone. These results are observed in vitro and 30 days after injection to the Lewis rats. Such data suggest that anti-CD4 monoclonal antibody can guide mature dendritic cells, usually involved in acute rejection, towards tolerance. The mechanisms are still to be resolved.
Simoneau-Robin
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I
Laboratoire Immunomanipulation et immunosuppresseurs en allo et auto-immunité, UPRES-EA 563, CHU Le Bocage, 2, boulevard Maréchal de Lattre de Tassigny, 21034 Dijon.
Mousson
C
C
Wijdenes
J
J
Rifle
G
G
D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism*; D015704:CD4 Antigens / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D006084:Graft Rejection; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011920:Rats, Inbred WF; D013154:Spleen / Q000276:immunology
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D007519:Isoantigens
Diminution de la réponse alloréactive in vitro et in vivo par association de cellules dendritiques matures du donneur et d'un anticorps monoclonal anti-CD4 chez le rat.