In vitro antibiotic susceptibility of field isolates of Mycoplasma synoviae in Argentina.
Minimum inhibitory concentrations (MICs) were determined in vitro for 7 antibiotics (aivlosin, enrofloxacine, tylosin, tiamulin, kitasamycin, chlortetracycline, and oxytetracycline) against eight recent local Argentinean isolates and two standard strains of Mycoplasma synoviae. Aivlosin (3-acetyl-4"-isovaleryl tylosin tartrate), tylosin, and tiamulin showed the lowest MICs with MIC90s of 0.006, 0.012, and 0.05 microg/ml, respectively. Except one strain that showed resistant values to chlortetracycline (> or = 12.5 microg/ml), all the analyzed strains were susceptible in different degrees to all the antibiotics tested. In this study, the improved activity of the tylosin-derived drug, aivlosin, was confirmed because it showed, in most strains, MIC values half those for tylosin.
Cerdá
R O
RO
Laboratorio de Diagnóstico e Investigaciones Bacteriológicas, Facultad de Ciencias Veterinarias-UNLP, La Plata, Bs. As., Argentina.
Giacoboni
G I
GI
Xavier
J A
JA
Sansalone
P L
PL
Landoni
M F
MF
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001118:Argentina; D003470:Culture Media; D024881:Drug Resistance, Bacterial; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D009174:Mycoplasma / Q000187:drug effects* / Q000254:growth & development; D015645:Tylosin / Q000031:analogs & derivatives* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D003470:Culture Media; C509469:aivlosin; D015645:Tylosin