title: Lack of association of diabetes with increased postoperative mortality and cardiac morbidity: results of 6565 major vascular operations.
abstract: OBJECTIVE
  A number of preoperative factors, including diabetes mellitus (DM), have been cited as increasing risk in patients undergoing major vascular operations. In smaller studies at our institution we have not found this to be apparent. This study reviewed all major vascular operations to confirm our bias that DM is not associated with increased mortality or cardiac morbidity.
  
  
  METHODS
  Case series retrospectively reviewed from a vascular registry established in 1990.
  
  
  METHODS
  Tertiary care center.
  
  
  METHODS
  Consecutive sample of 6565 patients who underwent lower extremity revascularization or carotid or aortic procedures, grouped by presence or absence of DM.
  
  
  METHODS
  Postoperative mortality, congestive heart failure, or myocardial infarction.
  
  
  RESULTS
  Patients with DM made up 62.3% of the population, and those without diabetes, 37.7%. Average age of the DM group was 67.1 years, with 61.3% male and 38.7% female. Average age of the non-DM group was 70.6 years, with 61.8% male and 38.2% female. The rates of overall postoperative mortality, myocardial infarction, and congestive heart failure were 1.14%, 1.59%, and 1.13%, respectively. Comparing the DM with the non-DM group, these rates were 0.96% vs 1.46%, 1.77% vs 1.30%, and 1.13% vs 1.14%, respectively. Using multivariate analysis, the DM group had an inverse relationship to perioperative death, with an odds ratio of 0.53 (P =.01). The factors that were associated with increased mortality were hemodialysis and history of congestive heart failure. Previous myocardial infarction was the only factor that predicted postoperative myocardial infarction. Kaplan-Meier survival curves showed a significantly decreased survival in the DM group during the next 5 years (P<.001).
  
  
  CONCLUSIONS
  Diabetes alone does not confer a higher mortality or cardiac morbidity rate with major vascular procedures. However, long-term survival is significantly worse in this group of patients.
authors.affiliation: Harvard Medical School, Division of Vascular Surgery, Beth Israel Deaconess Medical Center, West Campus, 110 Francis St, Suite 5B, Boston MA, 02215, USA. ahamdan@caregroup.harvard.edu
authors.forename: Allen D
authors.initials: AD
authors.lastname: Hamdan
authors.forename: Stephanie S
authors.initials: SS
authors.lastname: Saltzberg
authors.forename: Malachi
authors.initials: M
authors.lastname: Sheahan
authors.forename: James
authors.initials: J
authors.lastname: Froelich
authors.forename: Cameron M
authors.initials: CM
authors.lastname: Akbari
authors.forename: David R
authors.initials: DR
authors.lastname: Campbell
authors.forename: Frank W
authors.initials: FW
authors.lastname: LoGerfo
authors.forename: Frank B
authors.initials: FB
authors.lastname: Pomposelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001011:Aorta / Q000601:surgery; D002339:Carotid Arteries / Q000601:surgery; D048909:Diabetes Complications; D005260:Female; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D014656:Vascular Surgical Procedures / Q000009:adverse effects / Q000401:mortality*