The pathology of hibernating myocardium.
Myocardial hibernation represents a protective mechanism of muscle preservation in the setting of atherosclerotic coronary artery disease. Long-standing myocardial hypoperfusion leads to diminished myocardial contractility that reverses with improved blood flow after revascularization. The morphologic changes in both animal models and humans are described.
Berry
G J
GJ
Department of Pathology, Stanford University, Stanford, California 94305-5324, USA. gjberry@stanford.edu
Masek
M
M
D000222:Adaptation, Physiological; D000818:Animals; D001161:Arteriosclerosis / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D017682:Myocardial Stunning / Q000473:pathology* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology*; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000473:pathology / Q000503:physiopathology