Emergency dialysis in neonatal metabolic crises.
Metabolic crises in children with inborn errors of metabolism are caused by the accumulation of neurotoxic metabolites. Rapid elimination of these metabolites is apparently crucial to prevent irreversible neuronal damage; long-term outcome is correlated with the rate of toxin removal during the crisis. The usefulness of different blood purification techniques for removing accumulated neurotoxins is reviewed in this manuscript.
Daschner
Markus
M
Division of Pediatric Nephrology, Children's Hospital, University of Heidelberg, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany.
Schaefer
Franz
F
D004632:Emergency Medical Services; D006464:Hemoperfusion; D006801:Humans; D007231:Infant, Newborn; D008661:Metabolism, Inborn Errors / Q000628:therapy*; D010530:Peritoneal Dialysis; D016060:Sorption Detoxification