title: [Pharmacology of local anesthetics].
abstract: Over the past fifty years, many synthetic local anaesthetics have been developed with fewer side effects, increased specificity of action and a higher margin of safety than cocaine, the first local anaesthetic in clinical medicine. Although the route of administration may affect pharmacokinetics and pharmacodynamics, the present paper focuses on the general pharmacology of these useful compounds.
authors.affiliation: Onderzoekschool Neurowetenschappen Amsterdam/Onderzoekinstituut Neurowetenschappen, Vrije Universiteit te Amsterdam.
authors.forename: A L
authors.initials: AL
authors.lastname: Frankhuijzen
mesh_terms: D000766:Anesthesia, Dental / Q000295:instrumentation / Q000379:methods; D000779:Anesthetics, Local / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D004333:Drug Administration Routes; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D012449:Safety
chemical_list: D000779:Anesthetics, Local
vernacular_title: De farmacologie van lokale anaesthetica.