Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist.
There has been increasing interest in the use of selected genetically modified (GM) mouse models for the testing of chemicals to determine their carcinogenic potential. GM mouse models are believed to be useful tools that offer mechanistically relevant insights for understanding and predicting the human response to chemical exposure. They have been proposed as alternatives to the traditional 2-year mouse oncogenicity bioassay. In this overview we will review the GM mouse models that have been proposed as bioassay alternatives and present some of the key laboratory animal science challenges that need to be considered when using these unique animals.
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CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA.
Everitt
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D000822:Animal Husbandry; D000818:Animals; D015197:Carcinogenicity Tests / Q000379:methods*; D004268:DNA-Binding Proteins / Q000235:genetics; D004777:Environment; D016158:Genes, p53; D011905:Genes, ras; D005818:Genetic Engineering; D005838:Genotype; D006801:Humans; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics; D008817:Mice, Mutant Strains / Q000235:genetics; D008822:Mice, Transgenic / Q000235:genetics* / Q000378:metabolism; D015262:Xenobiotics / Q000378:metabolism; D051760:Xeroderma Pigmentosum Group A Protein
D004268:DNA-Binding Proteins; C497314:XPA protein, human; D015262:Xenobiotics; D051760:Xeroderma Pigmentosum Group A Protein; C497315:Xpa protein, mouse