Sensing the environment: a historical perspective on integrin signal transduction.
Cell adhesion mediated by integrin receptors has a critical function in organizing cells in tissues and in guiding haematopoietic cells to their sites of action. However, integrin adhesion receptors have broader functions in regulating cell behaviour through their ability to transduce bi-directional signals into and out of the cell and to engage in reciprocal interactions with other cellular receptors. This historical perspective traces the key findings that have led to our current understanding of these important functions of integrins.
Miranti
Cindy K
CK
Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Brugge
Joan S
JS
D000818:Animals; D002448:Cell Adhesion; D002455:Cell Division; D002470:Cell Survival; D003599:Cytoskeleton / Q000378:metabolism; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction
D016023:Integrins; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human