Hyperhomocysteinemia is common in patients with antiphospholipid syndrome and may contribute to expression of major thrombotic events.
Homocysteine plasma levels were measured by high-performance liquid chromatography in 52 patients with primary antiphospholipid syndrome (APS). Elevated homocysteine concentrations (>or= 15 micromol/l) were found in 16/52 (30.8%) APS patients. Elevated homocysteine levels were found to be associated with an increased risk for a major thromboembolic event (50 versus 16.7%, P = 0.014). Hyperhomocysteinemia is a common finding in APS patients, and may contribute to severity of thrombotic tendency observed in this syndrome.
Avivi
I
I
Thrombosis and Hemostasis Unit, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Haifa, Israel.
Lanir
N
N
Hoffman
R
R
Brenner
B
B
D000026:Abortion, Habitual / Q000097:blood / Q000209:etiology; D000328:Adult; D000368:Aged; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications*; D016009:Chi-Square Distribution; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012306:Risk; D013923:Thromboembolism / Q000097:blood / Q000209:etiology*
D006710:Homocysteine