title: Croblongifolin, a new anticancer clerodane from Croton oblongifolius.
abstract: A new furoclerodane, croblongifolin, together with one known clerodane, crovatin and one known labdane, nidorellol, were isolated from the stem bark of Croton oblongifolius. Structures were established based on spectroscopic and X-ray analysis. Croblongifolin showed a significant cytotoxicity against various human tumor cell lines including HEP-G2, SW620, CHAGO, KATO3 and BT474.
authors.forename: Sophon
authors.initials: S
authors.lastname: Roengsumran
authors.forename: Kusalin
authors.initials: K
authors.lastname: Musikul
authors.forename: Amorn
authors.initials: A
authors.lastname: Petsom
authors.forename: Tirayut
authors.initials: T
authors.lastname: Vilaivan
authors.forename: Polkit
authors.initials: P
authors.lastname: Sangvanich
authors.forename: Surachai
authors.initials: S
authors.lastname: Pornpakakul
authors.forename: Songchan
authors.initials: S
authors.lastname: Puthong
authors.forename: Chaiyo
authors.initials: C
authors.lastname: Chaichantipyuth
authors.forename: Nongnuj
authors.initials: N
authors.lastname: Jaiboon
authors.forename: Narongsak
authors.initials: N
authors.lastname: Chaichit
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D029802:Croton; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045785:Diterpenes, Clerodane; D004317:Doxorubicin / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045785:Diterpenes, Clerodane; D005663:Furans; D010936:Plant Extracts; C458700:croblongifolin; D004317:Doxorubicin