Development of the zebrafish inner ear.
Abstract Recent years have seen a renaissance of investigation into the mechanisms of inner ear development. Genetic analysis of zebrafish has contributed significantly to this endeavour, with several dramatic advances reported over the past year or two. Here, we review the major findings from recent work in zebrafish. Several cellular and molecular mechanisms have been elucidated, including the signaling pathways controlling induction of the otic placode, morphogenesis and patterning of the otic vesicle, and elaboration of functional attributes of inner ear.
Whitfield
Tanya T
TT
Centre for Developmental Genetics, University of Sheffield School of Medicine and Biomedical Science, Firth Court, Western Bank, Sheffield, United Kingdom. t.whitfield@sheffield.ac.uk
Riley
Bruce B
BB
Chiang
Ming-Yung
MY
Phillips
Bryan
B
D000818:Animals; D019521:Body Patterning; D007758:Ear, Inner / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development*; D004848:Epithelium; D006801:Humans; D009024:Morphogenesis; D015027:Zebrafish / Q000033:anatomy & histology / Q000196:embryology / Q000235:genetics / Q000254:growth & development*