[Effect of central administration of motilin on the activity of gastric-related neurons in brain stem and gastric motility of rats].
To investigate the effect of microinjection of motilin into ventral medail hypothalamus (VMH) or intracerebroventricle (icv) on gastric motility, extracellular unit responses of dorsal vagal complex (DVC) in anesthetized rats and gastric motility of conscious rats were recorded. The results are as follows. (1) The firing rate of gastric distention related neurons in DVC was modified. (2) VMH and icv administration of motilin induced obvious enhancement in gastric motility. (3) The effect of motilin on gastric motility was abolished by vagotomy. These results imply that central motilin appears to work as an excitatory neuromodulator in the regulation of gastric motility through VMH-DVC-vagal nerve axis.
Tang
M
M
Department of Physiology, College of Medicine, Qingdao University, Qingdao 266021, China. qmctm@public.qd.sd.cn
Zhang
H Y
HY
Jiang
Z Y
ZY
Xu
L
L
Peeters
T L
TL
D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D004594:Electrophysiology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D008845:Microinjections; D009037:Motilin / Q000494:pharmacology*; D009474:Neurons / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D009037:Motilin