[Effect of allicin on ethanol-induced hepatotoxicity in mice].
To study the effect of allicin, an effective component of garlic, on ethanol-induced hepatotoxicity in mice. The results showed that allicin (10 mg/kg ig, qd x 10) could reverse the higher activities of serum ALT and glutathione s-transferase (GST) in ethanol-treated mice. Furthermore, allicin could significantly enhance the content of hepatic reduced glutathione (GSH), and the activities of hepatic glutathione peroxidase (GSH-Px), glutathione reductase (GSH-Re) and GST in ethanol-induced hepatotoxicity mice. There were no remarkable changes in the hepatic catalase (Cat) and superoxide dismutase(SOD) activities. These results suggested that allicin have the effective hepato-protection on ethanol-induced hepatotoxicity, which is related to its selective effect on the glutathione-related enzyme system.
Wang
H
H
Department of Pharmacology, Hubei Medical University, Wuhan 430071, China.
Peng
R
R
Kong
R
R
Zeng
H
H
D000818:Animals; D004220:Disulfides; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism; D006519:Hepatitis, Alcoholic / Q000188:drug therapy / Q000201:enzymology*; D008297:Male; D051379:Mice; D013441:Sulfinic Acids / Q000494:pharmacology*
D004220:Disulfides; D013441:Sulfinic Acids; C006452:allicin; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase