title: [Frequency-specific responses of human brain to peripheral transcutaneous electric nerve stimulation: a functional magnetic resonance imaging study].
abstract: The purpose of the present investigation was to determine the responses of human brain to transcutaneous electric nerve stimulation (TENS) at different frequencies by functional magnetic resonance imaging (fMRI) examinations covering the whole brain of eleven healthy volunteers. Each subject received TENS at acupoints ST36 and SP6 of the left leg at the frequencies of 2 and 100 Hz. Frequency-specific responses were found in motor-related areas, thalamus, limbic system and associated cortex to stimulation of the two frequencies, while the primary somatosensory areas were activated by both. Therefore, it appears that 2 and 100 Hz TENS act through different neuro-pathways in the central nervous system.
authors.affiliation: Magnetic Resonance Imaging Unit, Hospital 306, Beijing 100101.
authors.forename: Z
authors.initials: Z
authors.lastname: Jin
authors.forename: W T
authors.initials: WT
authors.lastname: Zhang
authors.forename: F
authors.initials: F
authors.lastname: Luo
authors.forename: K L
authors.initials: KL
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: Y W
authors.initials: YW
authors.lastname: Zeng
authors.forename: J S
authors.initials: JS
authors.lastname: Han
mesh_terms: D026881:Acupuncture; D015669:Acupuncture Points; D000328:Adult; D001921:Brain / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009619:Nociceptors / Q000502:physiology; D004561:Transcutaneous Electric Nerve Stimulation