title: Regulation of gene expression in the PTS in Escherichia coli: the role and interactions of Mlc.
abstract: Mlc represses several glucose-related genes, including the phosphotransferase system (PTS) genes ptsHI and ptsG. Induction of these genes by glucose occurs as a response to the flux of glucose through the PTS and involves the sequestration of Mlc to membranes containing dephosphorylated PtsG. In addition, ptsG levels are post-transcriptionally regulated by the glycolytic flux. PtsG is, thus, subject to multiple layers of control that, in turn, feed back on the regulation of the PTS by Mlc. The regulatory function of Mlc is compared with that of FruR and of the PTS-regulation-domain-containing protein, BglG.
authors.affiliation: Institut de Biologie Physico-chimique, UPR9073, 13 rue Pierre et Marie Curie, 75005, Paris, France. plumbridge@ibpc.fr
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Plumbridge
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial; D005947:Glucose / Q000378:metabolism; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000235:genetics / Q000378:metabolism; D010770:Phosphotransferases / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D018085:Regulon; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic; D056968:Lac Repressors
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D005947:Glucose; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System; D010770:Phosphotransferases; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; C489416:FruR protein, E coli; C111065:Mlc protein, E coli; C064872:antiterminator proteins, Bacteria; C068837:FruR protein, Bacteria; D056968:Lac Repressors; C031629:phosphoenolpyruvate-glucose phosphotransferase