title: Emerging extended-spectrum beta-lactamases in Proteus mirabilis.
abstract: Beta-lactamase production was detected in 147 (52%) of 282 consecutive nonduplicate Proteus mirabilis isolates obtained over a 1-year period from the S. Matteo Hospital of Pavia (northern Italy). Seventy isolates (48% of the beta-lactamase producers) were found to produce extended-spectrum beta-lactamases (ESBLs), identified as PER-1 (first report in this species) and TEM-52 in 52 and 18 isolates, respectively. Analysis of clonal diversity of the ESBL producers suggested different spreading patterns for the two ESBL determinants.
authors.affiliation: Dipartimento di Scienze Morfologiche, Eidologiche e Cliniche, Sezione di Microbiologia, Università di Pavia, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Pagani
authors.forename: Roberta
authors.initials: R
authors.lastname: Migliavacca
authors.forename: Lucia
authors.initials: L
authors.lastname: Pallecchi
authors.forename: Cecilia
authors.initials: C
authors.lastname: Matti
authors.forename: Ernesto
authors.initials: E
authors.lastname: Giacobone
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Amicosante
authors.forename: Egidio
authors.initials: E
authors.lastname: Romero
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Rossolini
mesh_terms: D006801:Humans; D007525:Isoelectric Focusing; D008826:Microbial Sensitivity Tests; D011512:Proteus Infections / Q000382:microbiology*; D011513:Proteus mirabilis / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D047090:beta-Lactams; C445691:TEM-52 beta-lactamase; C108863:beta-lactamase PER-1; D001618:beta-Lactamases