Taenia solium cysticercosis: lymphocytes in the inflammatory reaction in naturally infected pigs.
Immunohistochemistry was used to examine the type of lymphocytes in muscle taeniosis-cysticercosis in naturally infected pigs. The inflammatory response studied was classified into lesions of grades 1, 3, and 5. In grade 1, with a minimal inflammatory infiltrate consisting of eosinophils and a few mononuclear cells, the immunostaining showed more CD4+ cells than CD8+ cells and IgM cells. In grade 3, when the granulomatous reaction was not yet well developed and the destruction of the parasite began, CD4+ and Ig M+ were the predominant cells, although CD8+ cells showed a notable increase. In grade 5, with a few parasitic structures surrounded by an extensive granulomatous infiltrate, lymphocyte subsets were decreased in number and did not show differences from grade 1 except for IgM+ cells, which remained increased. The organization of an active inflammatory response against the metacestode of Taenia solium in pigs includes the sequential participation of CD4+, CD8+ and IgM+ lymphocytes.
Pérez-Torres
Armando
A
Departamento de Biologia Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, DF.
Ustarroz
Martha
M
Constantino
Fernando
F
Villalobos
Nelly
N
de
Aluja Aline S
AA
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003551:Cysticercosis / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D006790:Host-Parasite Interactions; D007075:Immunoglobulin M / Q000032:analysis; D007150:Immunohistochemistry / Q000379:methods; D007249:Inflammation / Q000473:pathology / Q000662:veterinary; D016131:Lymphocyte Subsets / Q000276:immunology*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology* / Q000473:pathology; D041201:Taenia solium / Q000276:immunology*; D013622:Taeniasis / Q000276:immunology
D007075:Immunoglobulin M