Hypopituitarism, deficiency of factors V and VIII and von Willebrand factor: an uncommon association.
A 9 year-old boy with hypopituitarism and blood coagulation abnormalities is presented and discussed. The association between acquired von Willebrand disease and hypothyroidism has been reported but the combination of hypopituitarism and coagulopathy is unusual. Combined multiple clotting deficiencies are rare and, when present, factors V and VIII is the commonest association. Although it is known that hypothyroid patients may have a decrease in von Willebrand's factor (vWf) and factor VIII, there are no reports of hypopituitarism associated with combined deficiency of factors V, VIII, and vWf.
Setian
Nuvarte
N
Pediatric Endocrinology Unit, Instituto da Criança Hospital das Clinicas, São Paulo University School of Medicine, Fundação Pró-Sangue Hemocentro de São Paulo, Brazil.
Tanaka
Caroline M
CM
Damiani
Durval
D
Dichtchekenian
Vaê
V
Carneiro
Jorge D A
JD
D'Amico
Elbio A
EA
D001778:Blood Coagulation Disorders / Q000097:blood / Q000150:complications; D002648:Child; D005166:Factor V Deficiency / Q000150:complications*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D007018:Hypopituitarism / Q000097:blood / Q000150:complications* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010902:Pituitary Gland / Q000473:pathology; D014842:von Willebrand Diseases / Q000097:blood / Q000150:complications* / Q000473:pathology