title: Oral leishmaniasis in a HIV-positive patient. Report of a case involving the palate.
abstract: Leishmaniasis is a parasitic disease caused by a protozoon (Leishmania), with different clinical forms that are endemic in certain countries. The association of this disease in patients who are seropositive to human immunodeficiency virus (HIV) has recently been described. Leishmaniasis can develop in any stage of HIV infection, although the clinical manifestations - and hence the diagnosis - tend to coincide with the periods of maximum immune depression. We present the case of a HIV-positive, ex-intravenous drug abuser (in stage B2 of the CDC, 1992) with concomitant hepatitis C infection who presented with palatinal pain and bleeding for the past 2 months. Exploration revealed a vegetating tumoration of the hard palate. Hematoxylin-eosin and Giemsa staining of the biopsy confirmed the diagnosis of leishmaniasis. The definitive diagnosis was mucocutaneous leishmaniasis (MCL), for a bone marrow aspirate proved negative, and no further lesions could be established. The patient was treated with meglumine antimoniate (Glucantime), followed by improvement of the lesions.
authors.affiliation: Valencia University, Spain. milian@ctr.es
authors.forename: M A
authors.initials: MA
authors.lastname: Milián
authors.forename: J V
authors.initials: JV
authors.lastname: Bagán
authors.forename: Y
authors.initials: Y
authors.lastname: Jiménez
authors.forename: A
authors.initials: A
authors.lastname: Pérez
authors.forename: C
authors.initials: C
authors.lastname: Scully
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000473:pathology; D000328:Adult; D000981:Antiprotozoal Agents / Q000008:administration & dosage; D003937:Diagnosis, Differential; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D007275:Injections, Intravenous; D007897:Leishmaniasis, Mucocutaneous / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008536:Meglumine / Q000008:administration & dosage; D000077485:Meglumine Antimoniate; D009059:Mouth Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D009942:Organometallic Compounds / Q000008:administration & dosage; D021362:Palate, Hard / Q000473:pathology
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate