[Immunohistochemical study of P-cadherin in breast cancer].
BACKGROUND
Cell adhesion molecules play a significant role in the cellular connection of normal cells. The cadherins are believed to act as tumour suppressors, and their altered expression and function have been associated with tumour development.


OBJECTIVE
The authors examined the expression of a Ca++ dependent intercellular adhesion molecule, P-cadherin using an immunohistochemical method in 69 surgically resected breast carcinomas.


RESULTS
P-cadherin was detected in 30 cases (43.5%, cytoplasmic and/or membrane staining). The expression of P-cadherin was independent of tumour size and lymph node status, but correlated with a high tumour grade (grade III). In contrast, expression of E-cadherin correlated with lower tumour grade (grade I-II). P-cadherin expression was not detected in invasive lobular carcinomas.


CONCLUSIONS
In general, P-cadherin was expressed at a lower frequency compared to E-cadherin, alpha-, and beta-catenin. These results suggest that an inverse relationship may exist between E- and P-cadherin in relation to grade, and that the expression of P-cadherin may be a marker of aggressiveness.
Kovács
Anikó
A
Semmelweis Kórház, Miskolc, Patológiai Osztály.
Walker
Rosemary A
RA
Nagy
András
A
Gomba
Szabolcs
S
Jones
Louise
L
Dearing
Sheila
S
D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology*; D015820:Cadherins / Q000032:analysis*; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
D015820:Cadherins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
P-cadherin immunhisztokémiai vizsgálata emlórákokban.