Circulating monocyte chemoattractant protein-1 in heart transplant recipients with cardiac allograft vasculopathy.
OBJECTIVE
To evaluate serum Monocyte Chemoattractant Protein-1 (MCP-1) as a biologic marker of cardiac allograft vasculopathy (CAV) in heart transplant recipients (HTR).


METHODS
Serum levels of MCP-1 were measured in 49 HTR with and without CAV.


RESULTS
HTR exhibited significantly higher serum MCP-1 levels than controls. However, no difference was observed according to the existence of CAV.


CONCLUSIONS
Serum MCP-1 levels do not constitute a marker of the CAV occurring after heart transplantation.
Beaudeux
Jean Louis
JL
Service de Biochimie C, Groupe hospitalier Pitié-Salpêtrière, 83 boulevard de l'hôpital, 75013, Paris, France. jean-louis.beaudeux@psl.ap-hop-paris.fr
Dorent
Richard
R
Bernard
Maguy
M
Reagan
Mary
M
Foglietti
Marie José
MJ
Gandjbakhch
Iradj
I
Cacoub
Patrice
P
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D018932:Chemokine CCL2 / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood*; D019040:E-Selectin / Q000097:blood; D004730:Endothelium, Vascular / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D019007:P-Selectin / Q000097:blood; D014184:Transplantation, Homologous; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D015415:Biomarkers; D018932:Chemokine CCL2; D019040:E-Selectin; D019007:P-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1