title: Hemispheric cerebral gliomas in children with NF1: arguments for a long-term follow-up.
abstract: BACKGROUND
  Neurofibromatosis type 1, or peripheral neurofibromatosis, is the most form of common phakomatosis. In some instances, it can be associated with tumors of the central nervous system.
  
  
  METHODS
  We describe four cases of hemispheric cerebral glioma in children with NF1. Two of these tumors were pilocytic astrocytomas and two, ependymomas. We reviewed the literature on hemispheric cerebral gliomas in NF1 patients in an attempt to find characteristic features of and some explanations for these lesions.
  
  
  CONCLUSIONS
  We conclude that surgical resection of these tumors should be proposed whenever possible, with due consideration for their progressive nature and the uncertainties about malignancy. We advocate yearly clinical and neuroradiological follow-up over a long period in NF1 children, since they may develop additional CNS tumors during their lifetime.
authors.affiliation: Department of Pediatric Neurosurgery, Salengro Hospital, 59037 Lille cedex, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Riffaud
authors.forename: Matthieu
authors.initials: M
authors.lastname: Vinchon
authors.forename: Omar
authors.initials: O
authors.lastname: Ragragui
authors.forename: Isabelle
authors.initials: I
authors.lastname: Delestret
authors.forename: Marie-Madeleine
authors.initials: MM
authors.lastname: Ruchoux
authors.forename: Patrick
authors.initials: P
authors.lastname: Dhellemmes
mesh_terms: D001254:Astrocytoma / Q000175:diagnosis / Q000209:etiology*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D004806:Ependymoma / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications*; D013997:Time Factors