title: Biosynthesis of hibarimicins. III. Structures of new hibarimicin-related metabolites produced by blocked mutants.
abstract: Structures of metabolites produced by blocked mutants of Microbispora rosea subsp. hibaria TP-A0121, hibarimicin-producer, were determined by spectroscopic analysis. HMP-Y6 is the dimer of the west half of hibarimicin B, the aglycon of which is the genuine biosynthetic intermediate. HMP-P1 is the shunt product arising from the release of a methanol molecule from hibarimicinone. HMP-P4, the glycoside of HMP-P1, is glycosylated with two amicetoses and two digitoxoses same as hibarimicin B. HMP-M1, M2, M3 and M4 are shunt products derived from the monomeric undecaketide intermediates.
authors.affiliation: Biotechnology Research Center, Toyama Prefectural University, Kosugi, Toyama, Japan. yas@pu-toyama.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kajiura
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Furumai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hori
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Higashi
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Ishiyama
authors.forename: Masakazu
authors.initials: M
authors.lastname: Uramoto
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Uehara
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Oki
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D016296:Mutagenesis; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents