title: A descriptive analysis of minor depression.
abstract: OBJECTIVE
  The authors provide a detailed clinical description of minor depression: its symptoms, level of disability, stability, and relationship to patient and family history of major depressive disorder.
  
  
  METHODS
  Rigorous criteria for minor depression, including functional disability, were used to identify 226 individuals for a three-phase treatment study. This report presents data obtained on that study group during the first study phase, a 4-week placebo lead-in period.
  
  
  RESULTS
  One hundred sixty-two subjects (72% of the initial study group) remained in the study for 4 weeks and continued to meet criteria for minor depression. Minor depression in these subjects was primarily characterized by mood and cognitive symptoms, not the classical neurovegetative signs and symptoms of depression. Approximately one-third of the subjects with minor depression had a past history of major depressive disorder, and nearly half had a family history of unipolar depressive disorder; however, neither factor affected the severity or quality of minor depressive symptoms.
  
  
  CONCLUSIONS
  These data suggest that 1) minor depression is not evanescent; 2) minor depression is characterized by mood and cognitive symptoms rather than neurovegetative symptoms; 3) minor depression may occur either independently of a lifetime history of major depressive disorder or as a stage of illness in the course of recurrent unipolar depressive disorder; and 4) depressive disorders should be conceptualized as a continuum of severity.
authors.affiliation: Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, 92037, USA. mrapaport@ucsd.edu
authors.forename: Mark Hyman
authors.initials: MH
authors.lastname: Rapaport
authors.forename: Lewis L
authors.initials: LL
authors.lastname: Judd
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Schettler
authors.forename: Kimberly Ann
authors.initials: KA
authors.lastname: Yonkers
authors.forename: Michael E
authors.initials: ME
authors.lastname: Thase
authors.forename: David J
authors.initials: DJ
authors.lastname: Kupfer
authors.forename: Ellen
authors.initials: E
authors.lastname: Frank
authors.forename: John M
authors.initials: JM
authors.lastname: Plewes
authors.forename: Gary D
authors.initials: GD
authors.lastname: Tollefson
authors.forename: A John
authors.initials: AJ
authors.lastname: Rush
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D013001:Somatoform Disorders / Q000175:diagnosis / Q000235:genetics / Q000523:psychology