Nazarov reagents for convergent and expedient synthesis of new steroids.
[reaction: see text] A new methodology for the convergent synthesis of tetracyclic compounds was developed. Two new bicyclic Nazarov reagents of type II were synthesized, and their cycloaddition with 2-carbomethoxy-2-cyclohexenone I was studied. This cycloaddition afforded new interesting steroidal backbones.
Lepage
Olivier
O
Laboratoire de synthèse organique, Institut de pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4.
Stone
Charles
C
Deslongchamps
Pierre
P
D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D003512:Cyclohexanones / Q000737:chemistry; D007202:Indicators and Reagents; D008968:Molecular Conformation; D013256:Steroids / Q000138:chemical synthesis*
D001643:Bridged Bicyclo Compounds; D003512:Cyclohexanones; D007202:Indicators and Reagents; D013256:Steroids