Concurrent spinal cord and vertebral bone marrow radionecrosis 8 years after therapeutic irradiation.
Concurrent radionecrosis within the spinal cord and the bone marrow at the same thoracic level was observed 8 years after localized therapeutic irradiation in a patient who had undergone repeated cycles of radiotherapy, glucocorticoid treatment, and chemotherapy for a non-Hodgkin's lymphoma. Mechanisms combining radiotoxic potentialization by glucocorticoids/alkylating agents and delayed radiation-induced vasculitis involving the common arterial pathways to the spinal cord and to the vertebrae were speculated to have acted in a synergistic way.
Warscotte
L
L
Department of Neurology, Université catholique de Louvain, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Duprez
T
T
Lonneux
M
M
Michaux
L
L
Renard
L
L
Sindic
C J M
CJ
Lecouvet
F E
FE
D000328:Adult; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D010025:Osteoradionecrosis / Q000209:etiology*; D011832:Radiation Injuries / Q000175:diagnosis*; D011878:Radiotherapy / Q000009:adverse effects*; D013118:Spinal Cord Diseases / Q000209:etiology*; D013997:Time Factors