title: Value of corrected QT interval dispersion in identifying patients initiating dialysis at increased risk of total and cardiovascular mortality.
abstract: Cardiovascular disease remains the most common cause of premature death in end-stage renal disease (ESRD). Although several predictors of cardiac death have been reported, identifying individuals most at risk remains difficult. Previous studies in nonuremic populations have associated cardiac mortality, in particular sudden death, with increased QT dispersion (QTd); defined as the difference between the maximal and minimal QT interval on a standard electrocardiogram. The present study aimed to determine the prognostic value of QTd and corrected QTd (QTdc) in predicting total, cardiovascular, and arrhythmia-related mortality in ESRD patients initiating dialysis. The study was a retrospective cohort of adult ESRD patients starting peritoneal dialysis or hemodialysis between 1990 and 1994. Statistical analysis was by Cox proportional hazard modeling and Kaplan-Meier analysis. Primary study endpoints were total, cardiovascular, and arrhythmia-related mortality. Nonfatal cardiovascular events were a secondary endpoint. A total of 147 patients were studied for a period of 5 to 9 years. In Cox modeling, QTdc was an independent predictor of total (relative risk [RR] = 1.53; difference for RR = 50 msec; P = 0.0001) and cardiovascular mortality (RR = 1.57; difference for RR = 50 msec; P = 0.028) and trended toward arrhythmia-related mortality (P = 0.061). Total mortality also was predicted independently by lack of renal transplantation, radiographic cardiomegaly, and predialysis serum albumin. In multivariate analysis, QTdc was associated weakly with serum calcium, mean QT interval, and presence of diabetes mellitus. QTdc may be a useful marker for identifying dialysis patients at an increased risk for overall and cardiovascular mortality.
authors.affiliation: Division of Nephrology, McGill University, Montreal, Quebec, Canada. eliot_beaubien@hotmail.com
authors.forename: Eliot R
authors.initials: ER
authors.lastname: Beaubien
authors.forename: George B
authors.initials: GB
authors.lastname: Pylypchuk
authors.forename: Jawad
authors.initials: J
authors.lastname: Akhtar
authors.forename: H Jay
authors.initials: HJ
authors.lastname: Biem
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000401:mortality* / Q000503:physiopathology; D003936:Diagnosis, Computer-Assisted; D003956:Dialysis / Q000009:adverse effects / Q000401:mortality*; D005260:Female; D006801:Humans; D008133:Long QT Syndrome; D008297:Male; D008875:Middle Aged; D009026:Mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors