title: Combined brucella melitensis and streptococcal viridans endocarditis.
abstract: Infectious endocarditis is a potentially lethal inflammation of the hearts' inner lining invaded by microorganisms. The mortality from this illness increases as the number of infective organisms rises to 2, due to involvement of the left side of the heart. These microorganisms usually arise from the patient's own flora but can be acquired from the environment. Fever and heart murmurs are the principal clinical manifestations followed by a plethora of peripheral signs due to dissemination of microorganisms via the bloodstream. Echocardiographic imaging and sensitive culture techniques form the cornerstone of diagnosis. We report a patient with rheumatic heart disease who had combined brucella melitensis and streptococcus viridans endocarditis complicated by heart failure and an aortic root abscess. He was diagnosed on the basis of a history of prolonged fever and occupational risk as a shepherd, the presence of heart murmurs, positive blood cultures and echocardiographic evidence of aortic vegetations. He had an excellent response to intravenous antibiotic therapy combined with aortic valve replacement, which nowadays is regarded as the safest therapeutic approach for aortic valve endocarditis.
authors.affiliation: Department of Medicine, Riyadh Medical Complex, PO Box 3847, Riyadh 11481, Kingdom of Saudi Arabia. tsa@naseej.com.sa
authors.forename: Tarig S
authors.initials: TS
authors.lastname: Al-Khuwaitir
authors.forename: Bashir A
authors.initials: BA
authors.lastname: Wani
authors.forename: Suphia M
authors.initials: SM
authors.lastname: Sherbeeni
mesh_terms: D000900:Anti-Bacterial Agents; D017347:Brucella melitensis / Q000302:isolation & purification*; D002006:Brucellosis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006328:Cardiac Catheterization; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D017548:Echocardiography, Transesophageal; D004697:Endocarditis, Bacterial / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000628:therapy*; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012529:Saudi Arabia; D013290:Streptococcal Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D013291:Streptococcus / Q000145:classification*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents