Release of propranolol and diclofenac from low Mw DL-poly(lactic acid).
The controlled release of two drugs, i.e. the sodium salt of diclofenac and propranolol was studied, by using low molecular weight D,L-Poly(lactic acid) as a matrix. Tablets of the above polymer containing those drugs were immersed into buffers with various pH values and delivery was recorded as a function of time, via UV-spectroscopy. The results showed that the polymer is appropriate for such biomedical applications, as generally, it ensures complete drug delivery within 45-60 days, which is acceptable for most cases. On the other hand, the release rate depends on many parameters including the interactions among drug, matrix and the surrounding liquid, which adds complexity to the process and requires careful investigation for proper design of a controlled release system.
Mamouzelos
N J
NJ
National Technical University of Athens, Department of Chemical Engineering, Polymer Technology Lab. Iroon Polytechniou 9, Greece.
Proikakis
C S
CS
Tarantili
P A
PA
Andreopoulos
A G
AG
D001672:Biocompatible Materials; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004337:Drug Carriers; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000008:administration & dosage* / Q000737:chemistry; D008970:Molecular Weight; D011091:Polyesters; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry; D011433:Propranolol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D017550:Spectroscopy, Fourier Transform Infrared; D014783:Viscosity
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D004008:Diclofenac; D019344:Lactic Acid; C033616:poly(lactide); D011433:Propranolol