Rhinocerebral mucormycosis in the era of lipid-based amphotericin B: case report and literature review.
Rhinocerebral mucormycosis (RCM) is an invasive fungal infection that necessitates, in most cases, aggressive surgical debridement and high cumulative, often nephrotoxic doses of amphotericin B. A 50-year-old woman with RCM was treated successfully with amphotericin B lipid complex as primary therapy. The patient previously had displayed progressive intracranial involvement and rising serum creatinine levels while receiving the conventional (nonlipid) form of amphotericin B. A literature review identified only a few cases where systemic antifungal therapy was administered, with minimal or no surgery. Our case further supports that amphotericin B lipid complex can be used as primary therapy in selected patients with RCM, without the need for surgical exenteration.
Mondy
Kristin E
KE
Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Haughey
Bruce
B
Custer
Philip L
PL
Wippold
Franz J
FJ
Ritchie
David J
DJ
Mundy
Linda M
LM
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008055:Lipids / Q000627:therapeutic use*; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D012852:Sinusitis / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery
D000935:Antifungal Agents; D008055:Lipids; D000666:Amphotericin B