title: Symptomatic bradycardia secondary to interaction between topical timolol maleate, verapamil, and flecainide: a case report.
abstract: We present a case report describing an interaction between topical timolol maleate, verapamil, and flecainide resulting in symptomatic bradycardia. Adverse drug interactions, including topical medications, are relevant in the differential diagnosis of many presenting complaints.
authors.affiliation: Department of Emergency Medicine, Health Sciences Center, Winnipeg, Manitoba, Canada.
authors.forename: Travis
authors.initials: T
authors.lastname: Minish
authors.forename: Anthony
authors.initials: A
authors.lastname: Herd
mesh_terms: D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy; D001919:Bradycardia / Q000139:chemically induced*; D004347:Drug Interactions; D005260:Female; D005424:Flecainide / Q000009:adverse effects*; D005901:Glaucoma / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D013999:Timolol / Q000008:administration & dosage / Q000009:adverse effects*; D014700:Verapamil / Q000009:adverse effects*
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D013999:Timolol; D014700:Verapamil; D005424:Flecainide