[Leukocytic component in disseminated intravascular blood coagulation syndrome].
The experiments were carried out in nondescript rabbits. The animals were divided into two groups. Administered to both groups rabbits was the drug preparation "Efa-2"; in group II animals, inhibition of granulocytopoiesis was induced with myelosan. Group I rabbits developed hemostatic abnormalities characteristic of the subacute form of DIC-syndrome. Group II rabbits demonstrated hypercoagulation changes. In this way, inhibition of granulocytopoiesis and restriction of entering the blood of neutrophilic leucocytes lysosomal enzymes permit preventing the development of hemostatic disturbances characteristic of the DIC-syndrome by restricting the activity of both the sedimentation system and fibrinolysis.
Boiarchuk
E D
ED
Lunina
N V
NV
D000818:Animals; D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D005260:Female; D007958:Leukocyte Count; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D009504:Neutrophils / Q000201:enzymology* / Q000473:pathology* / Q000648:ultrastructure; D011817:Rabbits
Leĭkotsitarnyĭ komponent pri sindrome disseminirovannogo vnutrisosudistogo svertyvaniia krovi.