Long-term prognostic analysis of thymectomized patients with myasthenia gravis.
OBJECTIVE
To study the factors affecting the long-term prognosis of patients with myasthenia gravis (MG) after thymectomy.


METHODS
170 MG patients who had undergone thymectomies were studied retrospectively. Among them, 124 patients received long-term follow-up for more than 40 months postoperatively. The COX regression analysis model was used to analyze the factors that may influence the long-term prognosis. These factors included thymus pathology, patient gender, age, duration of disease at the time of surgery, preoperative Osserman classification and medication.


RESULTS
The research showed that thymus pathology was the single independent factor that affected the postoperative long-term prognosis. The long-term survival rates differed significantly with thymus pathological types: hyperplasia > benign thymoma > atrophy > malignant thymoma (P < 0.05).


CONCLUSIONS
The different pathological types of the thymus were the important factor affecting long-term survival in MG patients after thymectomy.
Liu
Wei
W
Department of Thoracic Surgery, The First Teaching Hospital of Norman Bethune University of Medical Sciences, Changchun 130021, China. davidliuw@hotmail.com
Tong
Ti
T
Ji
Zhendong
Z
Zhang
Zhenhe
Z
D000293:Adolescent; D000328:Adult; D000368:Aged; D001284:Atrophy / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications; D011379:Prognosis; D016019:Survival Analysis; D015996:Survival Rate; D013934:Thymectomy / Q000009:adverse effects*; D013945:Thymoma / Q000209:etiology; D013950:Thymus Gland / Q000473:pathology / Q000601:surgery; D013997:Time Factors