title: Synthesis of N-protected peptide alcohols catalyzed by subtilisin or alpha-chymotrypsin in organic solvents.
abstract: A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or alpha-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.
authors.affiliation: Ministry of Education, Department of Chemistry, Peking University, Beijing, P R, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Gui-Ling
authors.initials: GL
authors.lastname: Tian
authors.forename: Wai-Hung
authors.initials: WH
authors.lastname: Lo
authors.forename: Kin-Sing
authors.initials: KS
authors.lastname: Lee
authors.forename: Yun-Hua
authors.initials: YH
authors.lastname: Ye
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D002384:Catalysis; D002919:Chymotrypsinogen / Q000378:metabolism*; D009904:Optical Rotation; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D020860:Subtilisin / Q000378:metabolism*; D014867:Water / Q000737:chemistry
chemical_list: D000438:Alcohols; D012997:Solvents; D014867:Water; D002919:Chymotrypsinogen; D020860:Subtilisin