Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease.
Macrophage migration inhibitory factor (MIF) is a unique cytokine and critical mediator of host defenses with a role in septic shock and chronic inflammatory and autoimmune diseases. Its mechanism of action is incompletely understood. Here, we attempt to correlate current knowledge on the molecular pathways of MIF activity with its functions in immunity and disease.
Lue
Hongqi
H
Laboratory of Biochemistry, Institute for Interfacial Engineering, University of Stuttgart, 70569 Stuttgart, Germany.
Kleemann
Robert
R
Calandra
Thierry
T
Roger
Thierry
T
Bernhagen
Jürgen
J
D000818:Animals; D001161:Arteriosclerosis / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology; D000075686:COP9 Signalosome Complex; D004268:DNA-Binding Proteins / Q000378:metabolism; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008171:Lung Diseases / Q000276:immunology; D008263:Macrophage Migration-Inhibitory Factors / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D009369:Neoplasms / Q000098:blood supply / Q000276:immunology / Q000473:pathology; D010447:Peptide Hydrolases; D011971:Receptors, Immunologic / Q000378:metabolism; D012772:Shock, Septic / Q000276:immunology; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008263:Macrophage Migration-Inhibitory Factors; D011971:Receptors, Immunologic; D014157:Transcription Factors; C033184:macrophage migration inhibitory factor receptor; D010447:Peptide Hydrolases; C501488:COPS5 protein, human; D000075686:COP9 Signalosome Complex