Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide--a potential antileishmanial agent.
Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)-N-phenylacetamide (2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) in reducing the parasite load both in the spleen and liver at a much lower concentration in hamster models. The results suggest that the compound could be exploited as an antileishmanial drug.
Sahu
Niranjan P
NP
Steroid and Terpenoid Chemistry Division, Indian Institute of Chemical Biology, 4 Raja SC Mullick Road, Jadavpur, 700 032, Kolkata, India. npsahu@iicb.res.in
Pal
Chiranjib
C
Mandal
Nirup B
NB
Banerjee
Sukdeb
S
Raha
Mausumi
M
Kundu
Ashis P
AP
Basu
Anirban
A
Ghosh
Monidipa
M
Roy
Keshab
K
Bandyopadhyay
Santu
S
D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D000083:Acetanilides; D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D006224:Cricetinae; D007893:Leishmania donovani / Q000166:cytology / Q000187:drug effects / Q000254:growth & development; D007896:Leishmaniasis / Q000097:blood / Q000188:drug therapy / Q000201:enzymology / Q000469:parasitology; D008099:Liver / Q000187:drug effects / Q000469:parasitology; D008647:Mesocricetus; D015394:Molecular Structure; D013154:Spleen / Q000187:drug effects / Q000469:parasitology; D013997:Time Factors
C470913:2-(2-methylquinolin-4-ylamino)-N-phenylacetamide; D000081:Acetamides; D000083:Acetanilides; D000634:Aminoquinolines; D000981:Antiprotozoal Agents