title: Electroconvulsive Therapy Effects on Cerebrospinal Fluid Monoamine Metabolites and Platelet Serotonin Uptake In Melancholia.
abstract: The effects of ECT on 5-hydroxyindoleacetic acid, homovanillic acid (HVA), and 4-hydroxy-3-methoxyphenylglycol in cerebrospinal fluid and on kinetic parameters of platelet serotonin uptake were studied in 12 patients with melancholia. There were no significant changes in the monoamine metabolites 3 weeks after initiation of ECT in 12 patients; however, there was a tendency for HVA to increase. The V(max) of serotonin uptake (measured in seven patients) remained unchanged after ECT, but there was a significant increase in K(m), indicating a decreased affinity for serotonin in the carrier.
authors.affiliation: Department of Psychiatry, Danderyd Hospital, Danderyd, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Aberg-Wistedt
authors.forename: Björn
authors.initials: B
authors.lastname: Mårtensson
authors.forename: Leif
authors.initials: L
authors.lastname: Bertilsson
authors.forename: Rigmor
authors.initials: R
authors.lastname: Malmgren