title: Effect of sevoflurane on the mid-latency auditory evoked potentials measured by a new fast extracting monitor.
abstract: BACKGROUND
  Mid-latency auditory evoked potentials (MLAEP) are widely suppressed during general anesthesia and may therefore be useful for assessment of the depth of anesthesia. However, interpretation of amplitudes and latencies in the AEP signal is time consuming. A new monitor (A-line) that quantifies the MLAEP into an index has therefore been developed. The present study aimed to assess the precision of a prototype of the new monitor and to test the hypothesis that the depth of anesthesia index shows a graded response with changing steady-state end-expiratory concentrations of sevoflurane.
  
  
  METHODS
  We studied 10 ASA physical status I or II patients undergoing elective hysterectomy under combined epidural and general anesthesia by sevoflurane. Baseline auditory evoked potentials were recorded in the conscious patient immediately before induction of general anesthesia. Depth of anesthesia indices were recorded before anesthesia and at decreasing end-expiratory steady-state sevoflurane concentrations of 2.0%, 1.5%, 1.0% and 0.5%. All indices were recorded in duplicate 6 s apart. By use of an autoregressive model with exogenous input (ARX-model), the monitor extracted the AEP within 6 s. The depth of anesthesia AEP index calculated in this way was defined as the A-line ARX index (AAI).
  
  
  RESULTS
  Approximately 95% of the differences between repeated recordings were 5 AAI-units or less. A wide interindividual variation was observed at each observation point. AAI at 1%, 1.5% and 2% end-expiratory concentration was significantly less than the baseline AAI obtained before induction of anesthesia (P < 0.001). AAI did not change significantly in the 1-2% concentration range.
  
  
  CONCLUSIONS
  The new monitor was precise. Attenuation of the A-line ARX-index (AAI) for mid-latency auditory evoked potentials (MLAEP) during general anesthesia was profound. However, the monitor did not show a graded response with changing end-expiratory steady-state concentrations of sevoflurane.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Odense University Hospital, Odense, Denmark. alpiger@dadlnet.dk
authors.forename: S
authors.initials: S
authors.lastname: Alpiger
authors.forename: H S
authors.initials: HS
authors.lastname: Helbo-Hansen
authors.forename: E W
authors.initials: EW
authors.lastname: Jensen
mesh_terms: D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D000077149:Sevoflurane; D012815:Signal Processing, Computer-Assisted
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane