title: Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
abstract: The potential of purple sweet potato color (PSPC) and red cabbage color (RCC), natural anthocyanin food colors, to modify colorectal carcinogenesis was investigated in male F344/DuCrj rats, initially treated with 1,2-dimethylhydrazine (DMH) and receiving 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the diet. After DMH initiation, PSPC and RCC were given at a dietary level of 5.0% in combination with 0.02% PhIP until week 36. No PSPC or RCC-treatment-related changes in clinical signs and body weight were found. Incidences and multiplicities of colorectal adenomas and carcinomas in rats initiated with DMH were clearly increased by PhIP. In contrast, lesion development was suppressed by RCC, or tended to be inhibited by PSPC administration. Furthermore, in the non-DMH initiation groups, induction of aberrant crypt foci (ACF) by PhIP was significantly decreased by RCC supplementation. The results thus demonstrate that while PhIP clearly exerts promoting effects on DMH-induced colorectal carcinogenesis, these can be reduced by 5.0% PSPC or 5.0% RCC in a diet under the present experimental conditions.
authors.affiliation: Daiyu-kai Institute of Medical Science, 64 Goura, Nishiazai, Ichinomiya 491-0113, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hagiwara
authors.forename: Hiroko
authors.initials: H
authors.lastname: Yoshino
authors.forename: Toshio
authors.initials: T
authors.lastname: Ichihara
authors.forename: Mayumi
authors.initials: M
authors.lastname: Kawabe
authors.forename: Seiko
authors.initials: S
authors.lastname: Tamano
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Aoki
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Koda
authors.forename: Mikio
authors.initials: M
authors.lastname: Nakamura
authors.forename: Katsumi
authors.initials: K
authors.lastname: Imaida
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ito
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shirai
mesh_terms: D019813:1,2-Dimethylhydrazine / Q000633:toxicity; D000236:Adenoma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D000284:Administration, Oral; D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage / Q000627:therapeutic use*; D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001937:Brassica / Q000737:chemistry*; D002273:Carcinogens / Q000633:toxicity; D002277:Carcinoma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D003043:Cocarcinogenesis; D003106:Colon / Q000187:drug effects / Q000473:pathology; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D004032:Diet; D006965:Hyperplasia / Q000139:chemically induced / Q000473:pathology; D007093:Imidazoles / Q000633:toxicity; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D027723:Ipomoea batatas / Q000737:chemistry*; D008297:Male; D028321:Plant Preparations / Q000008:administration & dosage / Q000627:therapeutic use*; D011230:Precancerous Conditions / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D000872:Anthocyanins; D016588:Anticarcinogenic Agents; D002273:Carcinogens; D007093:Imidazoles; D028321:Plant Preparations; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; D019813:1,2-Dimethylhydrazine