title: Dauricine-induced changes in monophasic action potentials and effective refractory period of rabbit left ventricle in situ.
abstract: OBJECTIVE
  To study the effects of dauricine and sotalol on monophasic action potentials and effective refractory period of the rabbit heart in situ.
  
  
  METHODS
  Monophasic action potentials recording and programmed electrical stimulation techniques.
  
  
  RESULTS
  Iv injection of dauricine 0.5 mg . kg-1 . min-1 for 24 min produced a decrease of the amplitude of monophasic action potentials from (17+/-6) mV to (7.1 +/- 1.5) mV (P < 0.05) and increased the duration of 50 % and 90 % repolarization of monophasic action potentials and effective refractory period from (130 +/- 26), (167 +/- 25), (128 +/- 12) ms to (198 +/- 33), (235 +/- 34), (185 +/- 25) ms (P < 0.05), respectively. Sotalol had the similar effects on monophasic action potentials and effective refractory period to that of dauricine. Dauricine and sotalol did not change the ratio between effective refractory period and the duration of 90 % repolarization.
  
  
  CONCLUSIONS
  Dauricine and sotalol decreased the amplitude of monophasic action potentials and increased the duration of 50 % and 90 % repolarization and effective refractory period.
authors.affiliation: Institute of Clinical Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China. jsxia@sunm.shcnc.ac.cn
authors.forename: Jing-Sheng
authors.initials: JS
authors.lastname: Xia
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.forename: Jian-Wen
authors.initials: JW
authors.lastname: Dong
authors.forename: Hong
authors.initials: H
authors.lastname: Tu
authors.forename: Fan-Dian
authors.initials: FD
authors.lastname: Zeng
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000470:Alkaloids; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D044182:Benzylisoquinolines; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D012032:Refractory Period, Electrophysiological / Q000187:drug effects*; D044005:Tetrahydroisoquinolines; D016276:Ventricular Function
chemical_list: D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; D044182:Benzylisoquinolines; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C035934:dauricine