title: Cross-sensitivity between paroxetine and sertraline.
abstract: OBJECTIVE
  To report a case of possible cross-sensitivity between selective serotonin-reuptake inhibitors (SSRIs).
  
  
  METHODS
  A 20-year-old Southeast Asian man developed a maculopapular rash soon after starting paroxetine. Following resolution of this rash, another skin reaction with the same distribution and appearance occurred after sertraline therapy was started.
  
  
  CONCLUSIONS
  Cross-reactivity between drugs with similar structures has been reported; however, cross-reactivity among SSRI antidepressants is unexpected given their differences in chemical structure.
  
  
  CONCLUSIONS
  The possibility of cross-reactivity between SSRI antidepressants should be considered by clinicians who wish to switch from one SSRI to another due to a dermatologic reaction.
authors.affiliation: Department of Pharmaceutical Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. caroline_warnock@camh.net
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Warnock
authors.forename: Abbas G
authors.initials: AG
authors.lastname: Azadian
mesh_terms: D000328:Adult; D003863:Depression / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology*; D005076:Exanthema / Q000139:chemically induced*; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000009:adverse effects* / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D020280:Sertraline / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline