title: Genetic component to susceptibility to Trichuris trichiura: evidence from two Asian populations.
abstract: Trichuris trichiura is an helminthic infection with potentially severe health consequences. The hypothesis that host genetic factors can account for the distribution of Trichuris was tested using familial data on egg counts available for two populations, the Jirels of Nepal and the population of Jishan Island in Jiangxi Province of the People's Republic of China. Whipworm is highly prevalent in the Jishan Island population (86%), but occurs at a low rate in the Jirel population (14%). A quantitative genetic analysis was performed on each data set, using a variance component approach. Approximately 28% of the variation in Trichuris trichiura loads was attributable to genetic factors in both populations. Common household effects accounted for only 4% of the variation in the Jirels and none of the variation in the Jishan Island population. These concordant results from two separate populations provide strong evidence of the important role of genetics in determining differential susceptibility to whipworm infection.
authors.affiliation: Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549, USA. sarah@darwin.sfbr.org
authors.forename: Sarah
authors.initials: S
authors.lastname: Williams-Blangero
authors.forename: Stephen T
authors.initials: ST
authors.lastname: McGarvey
authors.forename: Janardan
authors.initials: J
authors.lastname: Subedi
authors.forename: Peter M
authors.initials: PM
authors.lastname: Wiest
authors.forename: Ram Prasad
authors.initials: RP
authors.lastname: Upadhayay
authors.forename: Dev R
authors.initials: DR
authors.lastname: Rai
authors.forename: Bharat
authors.initials: B
authors.lastname: Jha
authors.forename: G Richard
authors.initials: GR
authors.lastname: Olds
authors.forename: Wu
authors.initials: W
authors.lastname: Guanling
authors.forename: John
authors.initials: J
authors.lastname: Blangero
mesh_terms: D002681:China / Q000453:epidemiology; D005243:Feces / Q000469:parasitology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D009390:Nepal / Q000453:epidemiology; D010641:Phenotype; D014257:Trichuriasis / Q000453:epidemiology / Q000235:genetics*