Effects on development of the reproductive system in male offspring of rats given butyl benzyl phthalate during late pregnancy.
The objective of this study was to determine the effects of maternal exposure to butyl benzyl phthalate (BBP) on the development of the reproductive system in male offspring. Pregnant rats were given BBP by gastric intubation at 250, 500, or 1000 mg/kg on days 15 to 17 of pregnancy. A significant decrease in maternal body weight gain and food consumption was found in rats given BBP at 500 and 1000 mg/kg. A significant decrease in the number of live fetuses per litter was found at 1000 mg/kg. The weights of male and female fetuses were significantly decreased in the groups given BBP at 1000 mg/kg. A significant increase in the incidence of fetuses with undescended testes was found at 500 and 1000 mg/kg. A significant decrease in the anogenital distance (AGD) of male fetuses was observed at 500 and 1000 mg/kg. The AGD/cube root of body weight ratio in male fetuses was also significantly reduced at 500 mg/kg and higher. The AGD and AGD/cube root of body weight ratio of female fetuses in the BBP-treated groups were comparable to those in the control group. It was concluded that BBP on days 15 to 17 of pregnancy produced adverse effects on the development of the reproductive system in male offspring.
Ema
Makoto
M
National Institute of Health Sciences, Osaka Branch, 1-1-43 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan. ema@nihs.go.jp
Miyawaki
Emiko
E
D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D003456:Cryptorchidism / Q000139:chemically induced / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D020964:Embryo Loss / Q000139:chemically induced; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D020567:Fetal Weight / Q000187:drug effects; D005837:Genitalia, Male / Q000187:drug effects* / Q000196:embryology / Q000254:growth & development / Q000473:pathology; D008297:Male; D008431:Maternal-Fetal Exchange; D010795:Phthalic Acids / Q000633:toxicity*; D010968:Plasticizers / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D013997:Time Factors; D015430:Weight Gain / Q000187:drug effects
D010795:Phthalic Acids; D010968:Plasticizers; C027561:butylbenzyl phthalate