title: Preparation of substituted piperazinones via tandem reductive amination-(N,N'-acyl transfer)-cyclization.
abstract: [reaction: see text] A one-pot, tandem reductive amination-transamidation-cyclization reaction was employed to produce substituted piperazin-2-ones in good yields. Various amino acid methyl esters and transferable acyl groups were examined to establish the reaction's scope.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA. douglas_beshore@merck.com
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Beshore
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Dinsmore
mesh_terms: D000586:Amination; D003500:Cyclization; D008958:Models, Molecular; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D010879:Piperazines / Q000138:chemical synthesis*
chemical_list: D010879:Piperazines