[Anti-invasion activity of several plant-originated anticancer drugs with different mechanism of action].
The antitumor and anti-invasion activities of taxol, harringtonine, homoharringtonine and camptothecin on highly metastatic melanoma B16-BL6 and human fibrosarcoma HT-1080 cells were reported in this paper. Results demonstrated that taxol, harringtonine, homoharringtonine and camptothecin exhibited significant inhibition of cell growth of B16-BL6 and HT-1080 cells. Taxol, harringtonine and homoharringtonine were also found to be effective for the inhibition of cell invasion and migration of B16-BL6 cells, but camptothecin showed basically no effect at the indicated concentration.
Liu
H
H
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050.
Lei
X
X
Han
R
R
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002166:Camptothecin / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D005354:Fibrosarcoma / Q000473:pathology; D006248:Harringtonines / Q000494:pharmacology*; D000077863:Homoharringtonine; D006801:Humans; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D009361:Neoplasm Invasiveness; D017239:Paclitaxel / Q000494:pharmacology*; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D020946:Taxus / Q000737:chemistry; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006248:Harringtonines; C062500:harringtonin; D000077863:Homoharringtonine; D017239:Paclitaxel; D002166:Camptothecin