title: End-stage renal disease associated with familial Mediterranean fever.
abstract: A 39-year-old man had been suffering from periodic fever since childhood. He was started on hemodialysis due to secondary amyloidosis on December 2000. The patient was believed to have Familial Mediterranean fever (FMF) because of recurrent fever with peritonitis, arthritis and inflammatory changes and secondary amyloidosis in his kidneys, heart and colon. No other family member had recurrent fever. IL-6, TNF, and dopamine beta-hydroxylase were not increased in the febril phase. The patient was homozygous for the M6941 mutation. We report the first Japanese case of FMF associated with amyloidosis and confirmed by a gene mutation.
authors.affiliation: Third Department of Internal Medicine, University of The Ryukyus, Okinawa.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Tomiyama
authors.forename: Saori
authors.initials: S
authors.lastname: Oshiro
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Higashiuesato
authors.forename: Masanobu
authors.initials: M
authors.lastname: Yamazato
authors.forename: Atushi
authors.initials: A
authors.lastname: Sakima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tana
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tozawa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Muratani
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Iseki
authors.forename: Shuichi
authors.initials: S
authors.lastname: Takishita
mesh_terms: D000328:Adult; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000235:genetics; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male