title: Four highly oxygenated isopimarane-type diterpenes of Orthosiphon stamineus.
abstract: Four highly oxygenated isopimarane-type diterpenes, named orthosiphols O, P and Q and nororthosiphonolide A, have been isolated from the aerial parts of Orthosiphon stamineus from Myanmar, together with three known diterpenes, orthosiphols D and E and orthosiphonone A. Their structures were determined on the basis of extensive spectral analysis. All the isolated compounds displayed mild antiproliferative activities against highly liver metastatic colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cell lines.
authors.forename: Suresh
authors.initials: S
authors.lastname: Awale
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tezuka
authors.forename: Arjun H
authors.initials: AH
authors.lastname: Banskota
authors.forename: Kyoji
authors.initials: K
authors.lastname: Kouda
authors.forename: Kyaw Myint
authors.initials: KM
authors.lastname: Tun
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kadota
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D019686:Lamiaceae; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D004224:Diterpenes; D010936:Plant Extracts; C458723:nororthosiphonolide A; C458726:orthosiphol O; C458724:orthosiphol P; C458725:orthosiphol Q