title: Effect of calcium phosphate surface coating on bone ingrowth onto porous-surfaced titanium alloy implants in rabbit tibiae.
abstract: OBJECTIVE
  The purpose of the present study was to determine whether calcium phosphate coating has a significant impact on bone ingrowth into a porous titanium implant.
  
  
  METHODS
  Porous-surfaced titanium alloy Ti-6Al-4V implants were prepared with or without the addition of a thin surface layer of calcium phosphate applied by sol-gel coating. Implants were placed into the tibiae of 16 rabbits. Implanted sites were allowed to heal for 2 weeks, after which specimens were retrieved for morphometric assessment using backscatter scanning electron microscopy.
  
  
  RESULTS
  The data collected show that there is more extensive ingrowth into the porous regions of the calcium phosphate-coated implants than into the control implants. The weighted average ingrowth for the calcium phosphate-coated implants was 2.01, whereas that for the noncoated implants was 1.49; the difference is statistically significant (P <.01).
  
  
  CONCLUSIONS
  The addition of a thin layer of calcium phosphate to these implants appears to promote a more extensive implant-to-bone interface by allowing the neck regions to become intimately ingrown with bone even after only 2 weeks of initial healing.
authors.affiliation: Stomatology Center, Union Hospital, People's Republic of China. yangc715@public.wh.hb.cn
authors.forename: Cheng
authors.initials: C
authors.lastname: Yang
mesh_terms: D000497:Alloys; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects; D002130:Calcium Phosphates / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D020007:Implants, Experimental; D008297:Male; D016348:Osseointegration / Q000187:drug effects*; D016062:Porosity; D011817:Rabbits; D013977:Tibia; D014025:Titanium
chemical_list: D000497:Alloys; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C031462:titanium alloy (TiAl6V4); C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; D014025:Titanium; C485829:calcium phosphate, dibasic, anhydrous