Synthesis and structure-activity relationship of diarylamide urea derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells.
A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2o was superior to the lead compound, Tranilast, in terms of its potency of the inhibitory activity and cell selectivity.
Ogita
Haruhisa
H
Pharmaceuticals & Biotechnology Laboratory, Japan Energy Corporation, 3-17-35, Niizo-Minami, Saitama 335-8502, Toda-shi, Japan.
Isobe
Yoshiaki
Y
Takaku
Haruo
H
Sekine
Rena
R
Goto
Yuso
Y
Misawa
Satoru
S
Hayashi
Hideya
H
D001158:Arteries / Q000166:cytology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003331:Coronary Vessels / Q000166:cytology*; D004247:DNA / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D032389:Myocytes, Smooth Muscle / Q000166:cytology* / Q000187:drug effects*; D010671:Phenylurea Compounds / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D010671:Phenylurea Compounds; D004247:DNA