Searching for the mountains of the moon: genome scans for atherosclerosis.
Several research groups have begun mounting large, ambitious family studies to map genes for atherosclerosis, heart disease, and their major risk factors using whole genome linkage and/or disequilibrium scans. Some of the problems, pitfalls, and challenges of this exciting effort are examined and illustrated with lessons from an earlier mapping problem.
Province
Michael A
MA
Division of Biostatistics, Washington University School of Medicine, 660 South Euclid, Box 8067, St. Louis, MO 63110, USA. mike@wubios.wustl.edu
D001161:Arteriosclerosis / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006331:Heart Diseases / Q000235:genetics; D006801:Humans