title: Insulin sensitivity in type 2 diabetes: univariate and multivariate techniques to derive estimates of insulin sensitivity from the insulin modified intravenous glucose tolerance test (FSIGT).
abstract: The use of univariate and multivariate techniques to derive estimates of insulin sensitivity from the insulin modified FSIGT were investigated in 12 Type 2 diabetic subjects aged (mean+/-S.D.) 59+/-9.5 years and BMI 28.1+/-2.2 kg m(-2), who underwent both a FSIGT and an isoglycemic hyperinsulinemic clamp. Reproducibility of the FSIGT was tested in four patients on three separate occasions. FSIGT data were assessed by both univariate and multivariate techniques. The sensitivity index for the FSIGT ranged from 0.162 to 3.292 (mean 1.378) x 10(-4) x l min(-1) mU(-1) for the univariate approach and from 0.163 to 2.727 (mean 1.378) x 10(-4) x l min(-1) mU(-1) for the multivariate method. Mean S(Iclamp) was 44.41 x 10(-4) x l(-2) min(-1) x mU(-1) (range 22.0-77.92). The correlation of the insulin sensitivity indices between the clamp and the FSIGT was 0.51 (P=0.056) for the univariate and 0.67 (P=0.017) for the multivariate analyses. Repeated FSIGTs showed a lower variability for the multivariate than for the standard approach.
authors.affiliation: Medical Information Processing and Statistics, Novartis, Basel, Switzerland.
authors.forename: Guenther H
authors.initials: GH
authors.lastname: Mehring
authors.forename: Philip A
authors.initials: PA
authors.lastname: Coates
authors.forename: Patrick C
authors.initials: PC
authors.lastname: Brunel
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Luzio
authors.forename: David R
authors.initials: DR
authors.lastname: Owens
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D015309:Glucose Clamp Technique / Q000706:statistics & numerical data; D005951:Glucose Tolerance Test / Q000706:statistics & numerical data*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis
chemical_list: D001786:Blood Glucose; D007328:Insulin