title: [The plasma levels of proinsulin and true insulin and the effects of ramipril in hypertension].
abstract: OBJECTIVE
  To explore the dynamic changes of plasma proinsulin (PI) and true insulin (TI) and their relation with essential hypertension (EH) as well as to evaluate the therapeutic effect of ramipril.
  
  
  METHODS
  PI, TI and immunoreactive insulin (IRI) were measured in 44 cases of EH, 24 normal subjects and 21 cases of EH before and after treatment with ramipril.
  
  
  RESULTS
  The mean plasma level of PI and IRI in EH was significantly higher than that in the control group (P < 0.01); there was no significant difference in the level of TI (P > 0.05). PI was positively related to TI, There was no significant relation between PI with SBP and DBP. Plasma concentration of IRI and PI (P < 0.05), decreased remarkably, but the level of TI remained unchanged after therapy with ramipril (n = 21).
  
  
  CONCLUSIONS
  The plasma concentration of PI is elevated in patients with EH due probably to impaired function of beta-cells of the pancreatic islets. Ramipril can decrease the level of PI and improve pancreatic beta cell function.
authors.affiliation: The General Navy Hospital, Beijing 100037, China.
authors.forename: Guiming
authors.initials: G
authors.lastname: Zang
authors.forename: Ye
authors.initials: Y
authors.lastname: Yang
authors.forename: Xiangyun
authors.initials: X
authors.lastname: Shi
authors.forename: Zhaofu
authors.initials: Z
authors.lastname: Zhang
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Zhu
authors.forename: Lianru
authors.initials: L
authors.lastname: Gao
authors.forename: Hongying
authors.initials: H
authors.lastname: Wang
authors.forename: Guocai
authors.initials: G
authors.lastname: Yin
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011384:Proinsulin / Q000097:blood*; D017257:Ramipril / Q000627:therapeutic use*; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D000959:Antihypertensive Agents; D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D011384:Proinsulin; D002784:Cholesterol; D017257:Ramipril