Inherited factor VII deficiency and surgery: clinical data are the best criteria to predict the risk of bleeding.
Inherited factor VII (FVII) deficiency is a rare autosomal disorder characterized by a weak relationship between FVII activity (FVII:C) and operative bleeding risk. We report a retrospective study of 17 patients with a FVII:C below 0.1 IU/ml, in whom surgery was performed without any replacement therapy. Clinical and biological data were analysed to establish predictive criteria for bleeding tendency. We found that systematic preoperative replacement therapy may not be necessary for 'minor' surgical procedures, for patients suffering from inherited FVII deficiency, unless the clinical history includes severe haemorrhagic symptoms such as haemarthrosis, severe haematomas (even of soft tissue) or abundant epistaxis.
Giansily-Blaizot
Muriel
M
Laboratory of Haematology, University Hospital, Montpellier, France. m-giansily@chu-montpellier.fr
Biron-Andreani
Christine
C
Aguilar-Martinez
Patricia
P
de Moeloose
Philippe
P
Briquel
Marie-Elisabeth
ME
Goudemand
Jenny
J
Stieltjes
Nathalie
N
Barrot
Claire
C
Chambost
Herve
H
Durin
Anne
A
Gay
Valerie
V
Peynet
Jocelyne
J
Pouymayou
Katia
K
Schved
Jean-François
JF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D002648:Child; D005168:Factor VII Deficiency / Q000601:surgery*; D005260:Female; D020022:Genetic Predisposition to Disease; D006470:Hemorrhage / Q000235:genetics*; D006488:Hemostasis, Surgical; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors