title: Effect of topical diclofenac and ketorolac on patient discomfort and corneal sensitivity.
abstract: OBJECTIVE
  To determine if at clinical dosages, the topical nonsteroidal anti-inflammatory drugs diclofenac and ketorolac decrease corneal sensitivity, and if there is a difference in discomfort on instillation.
  
  
  METHODS
  In a double-masked study, 30 patients were randomized to receive two of three topical drops, Endosol, diclofenac sodium, and ketorolac tromethamine. A microaesthesiometer was used to evaluate corneal sensation. Baseline corneal sensitivity was obtained on each patient. Corneal sensory thresholds were remeasured at 7 and 15 minutes following eyedrop application. Patients also completed a questionnaire that graded the burning caused by the medications.
  
  
  RESULTS
  No significant decrease in corneal sensory thresholds was found with diclofenac or ketorolac compared with control at baseline (P = .50), 7 minutes (P = .41), or 15 minutes (P = .82). There was significantly more burning with diclofenac and ketorolac compared to control. There was a small but not statistically significant (P = .28) trend of more burning with ketorolac than diclofenac.
  
  
  CONCLUSIONS
  Neither diclofenac nor ketorolac were found to decrease corneal sensation compared to control. There was no significant difference in burning upon instillation reported by patients.
authors.affiliation: Turlock Eye Physicians Medical Group, CA, USA. narvaez@evestamail.com
authors.forename: Julio
authors.initials: J
authors.lastname: Narváez
authors.forename: Peter
authors.initials: P
authors.lastname: Kroll
authors.forename: James P
authors.initials: JP
authors.lastname: Guzek
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects / Q000502:physiology*; D004008:Diclofenac / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D020911:Ketorolac Tromethamine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D017060:Patient Satisfaction; D012677:Sensation / Q000187:drug effects*; D012684:Sensory Thresholds / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D004008:Diclofenac; D020911:Ketorolac Tromethamine