In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides.
Numerous natural compounds have a potential for therapeutic applications, but may have to be chemically modified to alter toxic side effects. We investigated structural parameters that could affect the cytotoxicity of isocoumarins similar to 9,10-dihydroxy-5,7-dimethoxy-1H-naphtho(2,3c)pyran-1-one (paepalantine 1). Paepalantine 1 has antimicrobial activity, as well as significant in vitro cytotoxic effects in the McCoy cell line. Two other natural and two semi-synthetic isocoumarins with similar structures obtained from the capitula of Paepalanthus bromelioides were tested on the same cell line by the neutral red assay. Substitution of the 9 and/or 10-OH group made these compounds less cytotoxic.
Devienne
Karina F
KF
Instituto de Química de Araraquara, SP, Brazil.
Raddi
MariaStellaG
M
Varanda
Eliana A
EA
Vilegas
Wagner
W
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity; D003374:Coumarins / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity*; D005347:Fibroblasts; D019668:Liliaceae / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D003374:Coumarins; D002945:Cisplatin