Effect of Trichodesma indicum extract on cough reflex induced by sulphur dioxide in mice.
The effect of methanol extract of whole plants of Trichodesma indicum R. Br. has been investigated on sulphur dioxide (SO2) induced cough reflex in Swiss albino mice. The extract has demonstrated significant (p < 0.001) inhibition in frequency of cough in all the tested doses when compared with untreated control group. The effect persisted up to 90 min of its oral administration and also comparable to that of the effect exhibited by the standard drug (Codeine phosphate). This study confirmed the traditional use of this plant in the treatment of cough. Determination of underlying mechanism of beneficial effect is major topic requiring further comprehensive investigation.
Srikanth
K
K
Murugesan
T
T
Kumar
Ch Anil
ChA
Suba
V
V
Das
A K
AK
Sinha
S
S
Arunachalam
G
G
Manikandan
L
L
D000284:Administration, Oral; D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D028082:Boraginaceae; D002855:Chromatography, Thin Layer; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012018:Reflex / Q000187:drug effects; D013458:Sulfur Dioxide
D000996:Antitussive Agents; D010936:Plant Extracts; D013458:Sulfur Dioxide