Genome-wide detection and family clustering of ion channels.
Ion channels represent an important class of molecules that can be classified into 13 distinct groups. We present a strategy using a "learning set" of well-annotated ion channel sequences to detect homologues in 32 entire genome sequences from Archaea, Bacteria and Eukarya. A total of 299 putative ion channel protein sequences were detected, with significant variations across species. The clustering of these sequences reveals complex relationships between the different ion channel families.
Harte
Rachel
R
Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK.
Ouzounis
Christos A
CA
D019843:Archaeal Proteins / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D019295:Computational Biology; D005057:Eukaryotic Cells; D016678:Genome; D007473:Ion Channels / Q000145:classification / Q000235:genetics*; D005810:Multigene Family / Q000235:genetics*; D010802:Phylogeny; D015221:Potassium Channels / Q000235:genetics; D017434:Protein Structure, Tertiary / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D019843:Archaeal Proteins; D001426:Bacterial Proteins; D007473:Ion Channels; D015221:Potassium Channels