Investigation of potential ionic interactions between anionic and cationic polymethacrylates of multiple coatings of novel colonic delivery system.
The objective of this work was to investigate potential interactions between anionic (Eudragit FS) and cationic (Eudragit RL) polymethacrylates of multiple coatings of a novel colonic drug delivery system. Aqueous films of pure polymers Eudragit FS (FS) and Eudragit RL (RL) and their superimposedfilm (FS-RL) were cast on glass slabs. The potential ionic interactions were studied by analysing the dried films using differential scanning calorimetry (DSC), Fourier transform-infrared spectroscopy (FT-IR), and nuclear magnetic resonance (NMR). The glass transition temperatures (Tg) of pure RL and FS were 60 degrees C and 22 degrees C, respectively; FS-RL showed two distinct glass transitions at 59 degrees C and 24 degrees C in the second heating cycle. In the 13C-MAS spectra of the samples in the solid state, no shifts of the resonance could be detected in the superimposed film compared with the pure polymers. The FT-IR spectra of the superimposed film did not show any significant shift of the bands of the -NMe3+ group of RL and the -COO- function of FS compared with the spectra of the pure polymers. No ionic interactions between anionic and cationic polymethacrylates were revealed by DSC, FT-IR, and NMR.
Gupta
Vishal K
VK
University of Georgia, College of Pharmacy, Department of Pharmaceutical and Biomedical Sciences, Athens 30602, USA. vishal.k.gupta@pharmacia.com
Beckert
Thomas E
TE
Deusch
Norbert J
NJ
Hariharan
Madhusudan
M
Price
James C
JC
D000838:Anions / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003106:Colon; D016503:Drug Delivery Systems; D011108:Polymers / Q000737:chemistry; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
D000838:Anions; D002412:Cations; D011108:Polymers; C058665:Eudragit RL; D019904:Polymethyl Methacrylate