title: Optimal neural network architecture selection: improvement in computerized detection of microcalcifications.
abstract: OBJECTIVE
  The authors evaluated the effect of optimal neural network architecture selection on the performance of a computer-aided diagnostic system designed to detect microcalcification clusters on digitized mammograms.
  
  
  METHODS
  The authors developed a computer program to detect microcalcification clusters automatically on digitized mammograms. Previously, they found that a properly selected and trained convolution neural network (CNN) could reduce false-positive (FP) findings and therefore improve the accuracy of microcalcification detection. In the current study, they evaluated the effectiveness of the CNN optimized with an automated optimization technique in improving the accuracy of the microcalcification detection program, comparing it with the manually selected CNN. An independent test data set was used, which included 472 mammograms selected from the University of South Florida public database and contained 253 biopsy-proved malignant clusters.
  
  
  RESULTS
  At an FP rate of 0.7 cluster per image, the film-based sensitivity was 84.6% for the optimized CNN, compared with 77.2% for the manually selected CNN. For clusters imaged on both craniocaudal and mediolateral oblique views, a cluster could be considered detected when it was detected on one or both views. For this case-based approach, at an FP rate of 0.7 per image, the sensitivity was 93.3% for the optimized and 87.0% for the manually selected CNN.
  
  
  CONCLUSIONS
  The classification of true and false signals is an important step in the microcalcification detection program. An optimized CNN can effectively reduce FP findings and improve the accuracy of the computer-aided detection system.
authors.affiliation: Department of Radiology, University of Michigan Hospitals, Ann Arbor 48109-0030, USA.
authors.forename: Metin N
authors.initials: MN
authors.lastname: Gurcan
authors.forename: Heang-Ping
authors.initials: HP
authors.lastname: Chan
authors.forename: Berkman
authors.initials: B
authors.lastname: Sahiner
authors.forename: Lubomir
authors.initials: L
authors.lastname: Hadjiiski
authors.forename: Nicholas
authors.initials: N
authors.lastname: Petrick
authors.forename: Mark A
authors.initials: MA
authors.lastname: Helvie
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000000981:diagnostic imaging*; D003936:Diagnosis, Computer-Assisted; D005260:Female; D006801:Humans; D008327:Mammography; D016571:Neural Networks, Computer; D011856:Radiographic Image Enhancement; D012680:Sensitivity and Specificity