Neutrophils are hyperactive in recurrent tonsillitis.
The pathogenesis of recurrent tonsillitis has not been fully explored. Most studies in this field have focused on pathogenic bacteria whereas less research has been done concerning the host defense. In earlier studies it was shown that there is an active cellular defense in the tonsillar surface secretion, consisting of phagocytes, and therefore in this study the possibility that this defense is altered in patients with recurrent tonsillitis was explored. Neutrophils were obtained from tonsillar surface secretions in eight patients with recurrent tonsillitis and eight healthy volunteers and the capacity of the neutrophils to respond to chemotactic stimuli was examined in an in vitro system. A significantly higher fraction of the neutrophils obtained from the patients with recurrent tonsillitis responded to chemotactic stimuli compared to those obtained from the healthy volunteers. It is concluded that there is a hyperactive cellular defense in the tonsillar surface secretion in patients with recurrent tonsillitis. This finding and its significance in the pathogenesis of recurrent tonsillitis are discussed.
Ebenfelt
Anders
A
Department of Otorhinolaryngology, Head and Neck Surgery, Sahlgrenska University Hospital, Göteborg, Sweden. anders.ebenfelt@mailer.gu.se
D000293:Adolescent; D000328:Adult; D006801:Humans; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D012008:Recurrence; D014069:Tonsillitis / Q000276:immunology*