title: Skeletal muscle fatty acid transport and transporters.
abstract: While it has long been assumed that long chain fatty acids (LCFA) can freely diffuse across the plasma membrane, recent work has shown that LCFA uptake also involves a protein-mediated mechanism. Three putative LCFA transporters have been identified (FABPpm, FATP, and FAT/CD36), and all are expressed in rodent and human muscles. In a new model system (giant vesicles), we have demonstrated that (a) LCFA transport rates are scaled with the oxidative capacity of heart and muscle, (b) only FABPpm and FAT/CD36, but not FATP1, correlate with vesicular LCFA transport, and (c) LCFA transport can be increased by increasing (1) the FAT/CD36 protein of muscle (chronic adaptation) or (2) via the translocation of FAT/CD36 from an intracellular pool to the plasma membrane during muscle contraction (acute adaptation).
authors.affiliation: Department of Physiology, Maastricht University, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Luiken
authors.forename: D
authors.initials: D
authors.lastname: Miskovic
authors.forename: Y
authors.initials: Y
authors.lastname: Arumugam
authors.forename: J F
authors.initials: JF
authors.lastname: Glatz
authors.forename: A
authors.initials: A
authors.lastname: Bonen
mesh_terms: D000818:Animals; D001692:Biological Transport; D018955:CD36 Antigens / Q000502:physiology; D002352:Carrier Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000502:physiology; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000502:physiology; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins
chemical_list: D018955:CD36 Antigens; D002352:Carrier Proteins; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins