The inhibitory effect of clindamycin on Lactobacillus in vitro.
OBJECTIVE
To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobocillus spp.


METHODS
Concentrations of clindamycin ranging from 1.95-20,000 microg/ml were studied for their effect on the growth of six strains of Lactobacillus.


RESULTS
Clindamycin concentrations between 1.95-31.25 microg/ml had no statistically significant effect on growth of lactobacilli (p > 0.05). Concentrations 125 and 250 microg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1,000 microg/ml.


CONCLUSIONS
High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus.
Aroutcheva
A
A
Department of Obstetrics and Gynecology, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL, USA.
Simoes
J A
JA
Shott
S
S
Faro
S
S
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D002981:Clindamycin