title: Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease.
abstract: Macrophage migration inhibitory factor (MIF) is a unique cytokine and critical mediator of host defenses with a role in septic shock and chronic inflammatory and autoimmune diseases. Its mechanism of action is incompletely understood. Here, we attempt to correlate current knowledge on the molecular pathways of MIF activity with its functions in immunity and disease.
authors.affiliation: Laboratory of Biochemistry, Institute for Interfacial Engineering, University of Stuttgart, 70569 Stuttgart, Germany.
authors.forename: Hongqi
authors.initials: H
authors.lastname: Lue
authors.forename: Robert
authors.initials: R
authors.lastname: Kleemann
authors.forename: Thierry
authors.initials: T
authors.lastname: Calandra
authors.forename: Thierry
authors.initials: T
authors.lastname: Roger
authors.forename: Jürgen
authors.initials: J
authors.lastname: Bernhagen
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology; D000075686:COP9 Signalosome Complex; D004268:DNA-Binding Proteins / Q000378:metabolism; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008171:Lung Diseases / Q000276:immunology; D008263:Macrophage Migration-Inhibitory Factors / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D009369:Neoplasms / Q000098:blood supply / Q000276:immunology / Q000473:pathology; D010447:Peptide Hydrolases; D011971:Receptors, Immunologic / Q000378:metabolism; D012772:Shock, Septic / Q000276:immunology; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008263:Macrophage Migration-Inhibitory Factors; D011971:Receptors, Immunologic; D014157:Transcription Factors; C033184:macrophage migration inhibitory factor receptor; D010447:Peptide Hydrolases; C501488:COPS5 protein, human; D000075686:COP9 Signalosome Complex