Insulin gene variable number of tandem repeats regulatory polymorphism is not associated with hyperandrogenism in Spanish women.
OBJECTIVE
To determine if the insulin gene variable number of tandem repeats (VNTR) regulatory polymorphism is associated with hyperandrogenism in a population of Spanish women.


METHODS
Controlled clinical study.


METHODS
Tertiary institutional hospital.


METHODS
Ninety-six hyperandrogenic patients and 38 healthy control women.


METHODS
Whole blood and serum samples were collected during the follicular phase of the menstrual cycle.


METHODS
Insulin gene VNTR regulatory polymorphism genotypes (classes I/I, I/III, and III/III alleles) and serum androgen levels. Insulin resistance was estimated from fasting glucose and insulin levels by using the homeostatic model assessment.


RESULTS
The frequencies of VNTR genotypes were 45.5%, 43.3%, and 11.2% for I/I, I/III, and III/III alleles considering patients and controls as a whole. These frequencies were not statistically different in controls (47.4%, 34.2%, and 18.4%) and in patients (44.8%, 46.9%, and 8.3%).


CONCLUSIONS
Hyperandrogenism and the insulin gene VNTR regulatory polymorphism are not associated in Spanish women.
Calvo
Rosa M
RM
Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain.
Tellería
Dolores
D
Sancho
José
J
San Millán
José L
JL
Escobar-Morreale
Héctor F
HF
D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000328:Adult; D000483:Alleles; D000735:Androstenedione / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006628:Hirsutism / Q000150:complications; D006720:Homozygote; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000150:complications / Q000235:genetics*; D007328:Insulin / Q000097:blood / Q000235:genetics*; D007333:Insulin Resistance; D018598:Minisatellite Repeats / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000150:complications; D011110:Polymorphism, Genetic / Q000235:genetics*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013030:Spain; D013739:Testosterone / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D019326:17-alpha-Hydroxyprogesterone