Acute toxicity of adjuvant doxorubicin and cyclophosphamide for early breast cancer -- a retrospective review of Chinese patients and comparison with an historic Western series.
A cohort of 85 Chinese breast cancer patients who received adjuvant chemotherapy with doxorubicin and cyclophosphamide was found to have a significantly higher incidence of grade 3 (n=44, 52%) and grade 4 (n=21, 25%) neutropenia when compared with an historic Western cohort. Also noted was a higher incidence of hepatotoxicity (n=8, 9%). When compared to Caucasian patients, the higher myelotoxicity in our patients may be related to ethnic variation in susceptibility to chemotherapy-related toxicity, lower body mass index with higher percentage of body fat composition, and the popular practice of concurrent alternative medicine during chemotherapy. The higher incidence of hepatoxicity was possibly associated with endemic chronic hepatitis B infection in this geographical area.
Ma
Brigette
B
Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Shatin, NT, Hong Kong.
Yeo
Winnie
W
Hui
Pun
P
Ho
Wing M
WM
Johnson
Philip J
PJ
D000505:Alopecia / Q000139:chemically induced; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000097:blood; D044466:Asian People; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000208:ethnology* / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D015331:Cohort Studies; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000097:blood; D003967:Diarrhea / Q000139:chemically induced; D004317:Doxorubicin / Q000009:adverse effects* / Q000097:blood; D005260:Female; D006801:Humans; D009503:Neutropenia / Q000139:chemically induced / Q000453:epidemiology; D012189:Retrospective Studies; D044465:White People
D004317:Doxorubicin; D003520:Cyclophosphamide