title: Type IV hypersensitivity to vitamin K.
abstract: The day after intramuscular injection of vitamin K1 (phytomenadione) into her thigh, a 27-year-old-woman with normal liver function developed a relapsing and remitting eczematous reaction localized to the injection site, and later a further eczematous reaction under an adhesive dressing (Duoderm). On patch testing, she was positive to vitamin K1 and cross-reacted to vitamin K4; she was also positive to colophonium and to ester gum rosin, the dressing adhesive. Recurrent angioedema persisted for several months and, 2 years later, symptoms were still occurring over the injection sites. Structure-activity relationships among vitamin K allergens are discussed.
authors.affiliation: Leeds Teaching Hospitals NHS Trust, Leeds, UK.
authors.forename: Sabine
authors.initials: S
authors.lastname: Sommer
authors.forename: S Mark
authors.initials: SM
authors.lastname: Wilkinson
authors.forename: Daniel
authors.initials: D
authors.lastname: Peckham
authors.forename: Caroline
authors.initials: C
authors.lastname: Wilson
mesh_terms: D000328:Adult; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D004485:Eczema / Q000139:chemically induced; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008968:Molecular Conformation; D010328:Patch Tests; D014812:Vitamin K / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D014812:Vitamin K