Use of medroxyprogesterone acetate in the treatment of Müllerian adenosarcoma: a case report.
BACKGROUND
Müllerianadenosarcoma is a rare pelvic malignancy that most commonly arises from the endometrium. These tumors are relatively insensitive to chemotherapy and radiation and are primarily treated by surgical resection. We report a case of müllerian adenosarcoma arising outside of the uterus from a background of endometriosis treated with a combination of surgical resection and medroxyprogesterone acetate.


METHODS
A 43-year-old woman with a history of endometriosis was diagnosed with advanced extrauterine müllerian adenosarcoma. After suboptimal tumor dubulking surgery she was treated with medroxyprogesterone acetate. Ten months postoperatively she remains without evidence of disease.


CONCLUSIONS
Medroxyprogesterone acetate may be a useful drug in the treatment of advanced müllerian adenosarcoma.
Hines
Brian J
BJ
Division of Gynecologic Oncology, New York University School of Medicine, New York, New York 10016, USA. hinesb@alum.mit.edu
Porges
Robert F
RF
Mittal
Kush
K
Muggia
Franco M
FM
Curtin
John P
JP
D018195:Adenosarcoma / Q000188:drug therapy* / Q000601:surgery; D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004715:Endometriosis / Q000150:complications; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use*; D018200:Mixed Tumor, Mullerian / Q000188:drug therapy* / Q000601:surgery
D018931:Antineoplastic Agents, Hormonal; D017258:Medroxyprogesterone Acetate