title: Fresh frozen bone in femoral impaction grafting: can developments in bone regeneration improve on this?
abstract: Major advances in the understanding of bone regeneration have led to revolutionary applications of bone conduction and induction. Revision hip surgery is on the increase with an active, ageing population demanding increased quality of life. The technically demanding instrumentation and materials necessary for revision prosthetic hip replacements have been rapidly incorporated into clinical practice. Unfortunately, advantage has not been taken of the basic and fundamental principles of bone induction and regeneration, available for many years now. In impaction grafting for revision hip replacements where fresh frozen bone is currently used as a standard, we argue and demonstrate from the literature why this technique is biologically inferior to the results which potentially can be gained by exploiting osteoinductive grafts such as demineralised bone matrix, hydroxyapetite, and inductive factors such as bone morphogenetic proteins.
authors.affiliation: Department of Maxillofacial Surgery, Kings College Hospital and School of Medicine and Dentistry, London, UK. chacma@globalnet.co.uk
authors.forename: M
authors.initials: M
authors.lastname: Heliotis
authors.forename: E E
authors.initials: EE
authors.lastname: Tsiridis
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods*; D015925:Cryopreservation; D005269:Femur / Q000601:surgery*; D006622:Hip Prosthesis / Q000009:adverse effects; D006801:Humans; D016348:Osseointegration; D010014:Osteolysis / Q000209:etiology / Q000601:surgery; D011475:Prosthesis Failure; D012038:Regeneration
chemical_list: D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes