title: High-dose therapy and autologous blood stem cell transplantation in POEMS syndrome.
abstract: We treated 5 patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome and multifocal bone lesions or diffuse bone marrow plasmacytic infiltration with high-dose therapy (HDT) and autologous blood stem cell transplantation. In all cases, the treatment produced remission of plasma cell proliferation associated with marked improvement in the patients' performance status, neurologic symptoms, and other manifestations of the syndrome. HDT with stem cell support should be investigated further as a therapeutic option in patients with POEMS syndrome and disseminated plasma cell dyscrasia.
authors.affiliation: Hematology Unit, Centre Hospitalier Universitaire, Limoges, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Jaccard
authors.forename: Bruno
authors.initials: B
authors.lastname: Royer
authors.forename: Dominique
authors.initials: D
authors.lastname: Bordessoule
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Brouet
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Fermand
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D002999:Clone Cells / Q000276:immunology / Q000473:pathology; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007136:Immunoglobulins / Q000097:blood / Q000652:urine; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology; D016878:POEMS Syndrome / Q000150:complications / Q000473:pathology / Q000628:therapy*; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology; D012074:Remission Induction; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007136:Immunoglobulins; D008558:Melphalan