title: Efficacious response with low-dose indapamide therapy in the treatment of type II diabetic patients with normal renal function or moderate renal insufficiency and moderate hypertension.
abstract: We examined the efficacy of low daily dose (1.25 mg/day) of indapamide in the treatment of high blood pressure in patients with diabetes mellitus with normal renal function and those with moderate renal insufficiency (serum creatinine <1.5 mg/dl). The study was an open label one of four months duration. Twenty-eight patients were enrolled in the study and only 15 completed it. Within 2 weeks of therapy, systolic blood pressure fell from 173 +/- 4.5 to 144 +/- 2.0 mm Hg and diastolic blood pressure from 96 +/- 2.1 to 80 +/- 1.8 mm Hg (p < 0.01) and blood pressure remained at these levels throughout the study. The results show that low dose indapamide is effective in the treatment of moderate hypertension in patients with diabetes mellitus who have normal renal function or moderate renal insufficiency. Therefore, this dose of 1.25 mg/day is recommended for the treatment of such patients.
authors.affiliation: Division of Nephrology and Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA.
authors.forename: Hosameldin
authors.initials: H
authors.lastname: Madkour
authors.forename: Kareim
authors.initials: K
authors.lastname: Ali
authors.forename: Saeid
authors.initials: S
authors.lastname: Nosrati
authors.forename: Shaul G
authors.initials: SG
authors.lastname: Massry
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007190:Indapamide / Q000008:administration & dosage*; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents; D007190:Indapamide