[Study on the changes of the levels of SOD and MDA in lung and MN in bone marrow exposed to cooking fume in rats].
In order to investigate the mechanism of the activities of superoxide dismutase (SOD) and the concentration of malondialdehyde (MDA) in lung and rate of micro-nucleus (MN) in bone marrow by which rape oil fume condensate(RC) exert their effect in rat lung, pouring into traches SD rat was performed with RC. Results showed that the SOD activities in RC and B(a)P groups were significantly higher than those in DMSO and control groups(P < 0.05). The concentrations of MDA were significantly lower than that in DMSO and control groups (P < 0.05). In experimental groups SOD/MDA decreased. MN rate significantly increased. It is concluded that lung tissue may be a target of RC.
Li
D
D
Department of Hygiene, Hengyang Medical College, Hengyang 421001, China.
Zhang
T
T
Rang
W
W
Wu
C
C
D000393:Air Pollutants / Q000633:toxicity*; D016902:Air Pollution, Indoor; D000818:Animals; D003296:Cooking; D008168:Lung / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
D000393:Air Pollutants; D009153:Mutagens; D008315:Malondialdehyde; D013482:Superoxide Dismutase