Mercury uptake and kinetics after ingestion of dental amalgam.
The aim of the present study was to investigate the G-1 uptake of mercury (Hg) after intake of a single dose of amalgam-Hg, followed by pharmacokinetic analysis of the data. Eleven volunteers without amalgam fillings ingested 1.00 g amalgam powder. Hg in plasma vs. time was analyzed with a two-compartment model by means of mixed-effects modeling. A fraction of the absorption rate of Hg to the central compartment was inversely proportional to the plasma ferritin levels. The population mean half-life of the terminal phase of Hg in plasma was 37 days, with a considerable standard deviation in the population. The absorbed fraction of the administered dose was estimated to be about 0.04%. It is concluded that the G-1 uptake of Hg is of quantitative importance during dental treatment.
af Geijersstam
E
E
Dept. of Basic Oral Sciences, School of Dentistry, Karolinska Institutet, Huddinge, Sweden.
Sandborgh-Englund
G
G
Jonsson
F
F
Ekstrand
J
J
D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D003723:Dental Amalgam; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D016013:Likelihood Functions; D008297:Male; D008628:Mercury / Q000097:blood / Q000493:pharmacokinetics*; D014168:Transferrin / Q000032:analysis
D014168:Transferrin; D003723:Dental Amalgam; D005293:Ferritins; D008628:Mercury