The role of protease inhibition with emphasis on the effects of inflammation and vascular immune phenomena.
This review discusses the role of protease inhibition with emphasis on the effects of inflammation and vascular immune phenomena in non-immunocompromised hosts. A vast body of knowledge elucidating the role of protease inhibition and hemostasis has accumulated in recent years. The two subjects are intimately linked, but the focus of this review is limited to the anti-inflammatory effects of protease inhibitors. In light of the particular expertise of the present authors, this review will focus on human studies and often cite work related to open-heart surgery, since in recent years this is the area in which a large effort has been concentrated worldwide.
Bilfinger
T V
TV
Cardiothoracic Division, Department of Surgery, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794, USA. bilfinger@surg.som.sunysb.edu
Stefano
George B
GB
D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects; D001929:Brain Edema / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000503:physiopathology; D009504:Neutrophils / Q000187:drug effects; D011480:Protease Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D015843:Serpins / Q000494:pharmacology / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D011480:Protease Inhibitors; D015842:Serine Proteinase Inhibitors; D015843:Serpins