title: Troponin T in the first 24 hours after the administration of chemotherapy and the detection of myocardial damage in children.
abstract: Early detection of damage to cardiac myocytes after cardiotoxic chemotherapy in paediatric patients may allow timely preventive measures to be taken. We investigated the diagnostic value of cardiac troponin T (cTnT) after the administration of cardiotoxic chemotherapy. In 38 children, cTnT levels were measured at three time points during the first 24 h after 58 cardiotoxic chemotherapy cycles (163 samples). An abnormal cTnT level, defined as a cTnT>0.010 ng/ml, was measured in only six samples from 3 patients. After completion of chemotherapy, 7 out of the 38 patients had left ventricular dysfunction (LV dysfunction). Only 1 of these 7 patients had an elevated cTnT level. 2 other patients with elevated cTnT levels did not develop LV dysfunction until 2 and 7 months after the cTnT measurement. Our data show that the measurement of cTnT within 24 h after administration of chemotherapy does not have a high sensitivity for the identification of patients with subsequent subclinical cardiotoxicity.
authors.affiliation: Department of Pediatric Oncology, Academic Medical Center, Emma Kinder Ziekenhuis, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. l.c.kremer@amc.uva.nl
authors.forename: L C M
authors.initials: LC
authors.lastname: Kremer
authors.forename: B A J
authors.initials: BA
authors.lastname: Bastiaansen
authors.forename: M
authors.initials: M
authors.lastname: Offringa
authors.forename: J
authors.initials: J
authors.lastname: Lam
authors.forename: J P
authors.initials: JP
authors.lastname: van Straalen
authors.forename: R J
authors.initials: RJ
authors.lastname: de Winter
authors.forename: P A
authors.initials: PA
authors.lastname: Voûte
mesh_terms: D000293:Adolescent; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D002648:Child; D006801:Humans; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013997:Time Factors; D020107:Troponin T / Q000097:blood*; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D015415:Biomarkers; D020107:Troponin T