title: Chronic eosinophilic leukaemia presenting with erythroderma, mild eosinophilia and hyper-IgE: clinical, immunological and cytogenetic features and therapeutic approach. A case report.
abstract: A 23-year-old, white male metallurgist presented with pruritic erythematous maculo-papules over the trunk and upper limbs and 6 months later developed erythroderma, eosinophilia and multi-organ dysfunction. A diagnosis of chronic eosinophilic leukaemia was made on the basis of myeloproliferative involvement of both peripheral blood and bone marrow, associated with eosinophilic differentiation and a t(5;12)(q33;p13) translocation. The initial therapeutic approach was interferon alfa-2b plus cytosine arabinoside, for 13 months, followed by hydroxyurea plus vincristine. There was improvement of skin lesions, disappearance of eosinophilia and decrease of serum immunoglobulin E, towards normal values.
authors.affiliation: Department of Clinical Haematology, Hospital Geral de São João, Porto, Portugal. elisagranjo@netc.pt
authors.forename: E
authors.initials: E
authors.lastname: Granjo
authors.forename: M
authors.initials: M
authors.lastname: Lima
authors.forename: J M
authors.initials: JM
authors.lastname: Lopes
authors.forename: S
authors.initials: S
authors.lastname: Dória
authors.forename: A
authors.initials: A
authors.lastname: Orfão
authors.forename: S
authors.initials: S
authors.lastname: Ying
authors.forename: L T
authors.initials: LT
authors.lastname: Barata
authors.forename: M
authors.initials: M
authors.lastname: Miranda
authors.forename: N C P
authors.initials: NC
authors.lastname: Cross
authors.forename: B J
authors.initials: BJ
authors.lastname: Bain
mesh_terms: D000328:Adult; D002908:Chronic Disease; D020732:Cytogenetic Analysis; D003873:Dermatitis, Exfoliative / Q000209:etiology; D003937:Diagnosis, Differential; D004802:Eosinophilia; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000145:classification / Q000175:diagnosis* / Q000628:therapy; D016130:Immunophenotyping; D007589:Job Syndrome / Q000175:diagnosis; D008297:Male; D009196:Myeloproliferative Disorders / Q000145:classification / Q000175:diagnosis