title: The inhibitory effect of clindamycin on Lactobacillus in vitro.
abstract: OBJECTIVE
  To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobocillus spp.
  
  
  METHODS
  Concentrations of clindamycin ranging from 1.95-20,000 microg/ml were studied for their effect on the growth of six strains of Lactobacillus.
  
  
  RESULTS
  Clindamycin concentrations between 1.95-31.25 microg/ml had no statistically significant effect on growth of lactobacilli (p > 0.05). Concentrations 125 and 250 microg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1,000 microg/ml.
  
  
  CONCLUSIONS
  High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus.
authors.affiliation: Department of Obstetrics and Gynecology, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL, USA.
authors.forename: A
authors.initials: A
authors.lastname: Aroutcheva
authors.forename: J A
authors.initials: JA
authors.lastname: Simoes
authors.forename: S
authors.initials: S
authors.lastname: Shott
authors.forename: S
authors.initials: S
authors.lastname: Faro
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin