Epithelioid trophoblastic tumor of the uterus: cytological and immunohistochemical observation of a case.
Epithelioid trophoblastic tumor (ETT) is a new entity of trophoblastic tumor and 14 such cases were reported by Shih and Kurman in 1998. However, only three subsequent cases supporting ETT have been reported. Recently, we experienced a case of ETT in a 37-year-old woman whose preoperative endometrial brushings showed atypical mononucleate giant cells and who underwent hysterectomy with the diagnosis of a uterine fibroid. The specimens revealed a 2.5 x 3.0 cm yellow-tan intramural nodule located in the lower uterine segment, which was composed of a neoplastic proliferation of intermediate trophoblasts in epithelioid arrangements. Immunohistochemically, the tumor cells were diffusely positive for cytokeratin and inhibin-alpha, and focally positive for human chorionic gonadotropin and human placental lactogen. She presented an uneventful clinical course as of September 2001.
Kamoi
Seiryu
S
Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan. skamoi@nms.ac.jp
Ohaki
Yoshiharu
Y
Mori
Osamu
O
Yokoyama
Munehiro
M
Kawamoto
Youko
Y
Kawamura
Takashi
T
Araki
Tsutomu
T
D000328:Adult; D006063:Chorionic Gonadotropin / Q000032:analysis; D015622:Epithelioid Cells / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000032:analysis; D007633:Keratins / Q000032:analysis; D010928:Placental Lactogen / Q000032:analysis; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000378:metabolism / Q000473:pathology*; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology*
D006063:Chorionic Gonadotropin; D007265:Inhibins; D007633:Keratins; D010928:Placental Lactogen