title: [Long-term follow-up of home parenteral nutrition at a general hospital: complications and quality of life].
abstract: OBJECTIVE
  The present study assesses the septic, thrombotic and hepatic complications and also the quality of life of patients with home parenteral nutrition (NPD in its Spanish acronym).
  
  
  METHODS
  The case histories of patients treated with NPD at our hospital were collected for the period January, 1986, to January, 2001. We had 20 patients, mean age 48 +/- 14 years (mean +/- SD), with a total catheterization time of 16,292 days. The main causes of intestinal failure were mesenteric ischaemia and radical enteritis. Quality of life was assessed by means of the Sickness Impact Profile (SIP) and the Karnofsky Index (KI).
  
  
  RESULTS
  We found a catheter infection rate of 0.42 per 100 days of catheter, mostly produced by coagulase-negative staphylococci (63%). In 30% of the cases, it was necessary to remove the catheter, including in all cases produced by Candida. Cather occlusion rate was 0.05 per 100 days. Five patients presented an increase in transaminases and alkaline phosphatase, and one female patient developed cholestasis. Two patients died of NPD-related causes. The results of the quality of life analysis showed it was moderately affected, with SIP scores of 14.6 +/- 3.5 and KI results of 70 +/- 20 (mean +/- SD).
  
  
  CONCLUSIONS
  Home parenteral nutrition allows a greater survival in cases of intestinal failure. The most frequent complication is an infection of the catheter. The results of the quality of life analysis in our series reveal it was moderately affected in most cases.
authors.affiliation: Sección de Nutrición Clínica y Dietética, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo, 46, 28007 Madrid. nutri@pgob.hggm.es
authors.forename: C
authors.initials: C
authors.lastname: Cuerda
authors.forename: M
authors.initials: M
authors.lastname: Camblor
authors.forename: I
authors.initials: I
authors.lastname: Bretón
authors.forename: P
authors.initials: P
authors.lastname: García-Peris
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006769:Hospitals, General; D006801:Humans; D008297:Male; D008875:Middle Aged; D016331:Parenteral Nutrition, Home / Q000009:adverse effects*; D011788:Quality of Life; D012189:Retrospective Studies; D013997:Time Factors
vernacular_title: Seguimiento a largo plazo de la nutrición parenteral domiciliaria en un hospital general: complicaciones y calidad de vida.