Emergence of multiple drug-resistant human cytomegalovirus variants in 2 patients with human immunodeficiency virus infection unresponsive to highly active antiretroviral therapy.
In 2 patients infected with human immunodeficiency virus (HIV), highly active antiretroviral therapy was unable to suppress HIV replication as a result of the emergence of drug-resistant HIV variants. Human cytomegalovirus (HCMV) retinitis developed in both patients, and an unusually complex mixture of drug-resistant HCMV variants was detected in both patients.
Baldanti
Fausto
F
Servizio di Virologia, and Laboratori Sperimentali di Ricerca, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.
Paolucci
Stefania
S
Parisi
Aldo
A
Meroni
Luca
L
Gerna
Giuseppe
G
D017088:AIDS-Related Opportunistic Infections / Q000821:virology*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D003587:Cytomegalovirus / Q000187:drug effects* / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000209:etiology / Q000821:virology; D017726:Cytomegalovirus Retinitis / Q000209:etiology / Q000821:virology*; D018432:Drug Resistance, Multiple; D006678:HIV / Q000187:drug effects; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D014779:Virus Replication / Q000187:drug effects