[Antimetastatic effects of arginine-aspartate on salivary adenoid cystic carcinoma in vitro].
OBJECTIVE
To test the effects of arginine-aspartate (RD) on metastasis of salivary cystic carcinoma (SACC).


METHODS
Highly metastatic SACC cell line SACC-LM was used in the study. The effect of RD on tumor cell-ECM adhesion was assayed by MTT technique. The effect of RD on invasion and migration of SACC-LM were evaluated using modified boyden chamber.


RESULTS
RD inhibited tumor cell fibronectin adhesion at 5 mg/L concentration, but no effects on tumor cell laminin and tumor cell type IV collagen adhesion. RD inhibited the invasion at 1, 5, 25 mg/L, and inhibited the migration only at 25 mg/L.


CONCLUSIONS
The result shows that the RD has an antimetastatic effect on SACC-LM cells in vitro.
Li
F
F
Department of Stomatology, International Peace Hospital, Shijiazhuang 050082, China.
Yu
G
G
Peng
S
S
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001120:Arginine / Q000494:pharmacology*; D001224:Aspartic Acid / Q000494:pharmacology*; D003528:Carcinoma, Adenoid Cystic / Q000188:drug therapy*; D002448:Cell Adhesion / Q000187:drug effects; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D012468:Salivary Gland Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D001224:Aspartic Acid; D001120:Arginine; C024891:arginine aspartate