Fluorimetric determination of isoxsuprine hydrochloride in pharmaceuticals and biological fluids.
Two simple and highly sensitive fluorimetric methods have been developed for the determination of isoxsuprine hydrochloride in bulk, in dosage forms and in biological fluids. The first method involves the direct measurement of the native fluorescence of the drug in the concentration range 0.4-4.0 microg ml(-1), the second method is based on the oxidation of isoxsuprine HCl with cerium(IV) followed by fluorimetric measurement in the concentration range 0.02-0.2 microg ml(-1). The average % found were 99.9 +/- 0.78 and 100.0 +/- 0.62 for the two methods, respectively. The minimum detectability (3 S(B)) were 0.11 and 0.007 microg ml(-1) for the two methods, respectively. The methods results showed insignificant difference with those of the official method.
Alarfaj
Nawal A A
NA
Women Student-Medical Studies and Sciences Sections, Department of Chemistry, College of Science, King Saud University, PO Box 22452, Riyadh 11495, Saudi Arabia. n-alarfaj@maktoob.com
D000318:Adrenergic beta-Agonists / Q000032:analysis* / Q000097:blood / Q000652:urine; D002563:Cerium / Q000737:chemistry; D006801:Humans; D007202:Indicators and Reagents; D007556:Isoxsuprine / Q000032:analysis* / Q000097:blood / Q000652:urine; D010084:Oxidation-Reduction; D013050:Spectrometry, Fluorescence; D013607:Tablets
D000318:Adrenergic beta-Agonists; D007202:Indicators and Reagents; D013607:Tablets; D002563:Cerium; D007556:Isoxsuprine