title: [A case of allopurinol-induced muscular damage in a chronic renal failure patient].
abstract: A 73-year-old woman with chronic renal failure developed generalized muscular weakness and pain 6 days after the start of allopurinol treatment(200 mg/day). Routine laboratory tests revealed elevated levels of serum creatine kinase, and the patient was clinically diagnosed as rhabdomyolysis, due probably to severe myositis. A high level of serum oxipurinol, the chief active metabolite of allopurinol, was also revealed. The muscular weakness was relieved in seven weeks with intermittent hemodiafiltration.
authors.affiliation: Department of Nephrology, Department of Orthopedics, Sakura National Hospital, Chiba, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Terawaki
authors.forename: Takahide
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Toshio
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Takase
authors.forename: Tetsuharu
authors.initials: T
authors.lastname: Nemoto
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Hosoya
mesh_terms: D000368:Aged; D000493:Allopurinol / Q000009:adverse effects*; D005260:Female; D017583:Hemodiafiltration; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D009220:Myositis / Q000139:chemically induced* / Q000628:therapy; D010117:Oxypurinol / Q000097:blood; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000628:therapy
chemical_list: D000493:Allopurinol; D010117:Oxypurinol