title: [A case of hepatic metastasis from rectal carcinoma successfully treated with pharmacokinetic modulating chemotherapy (PMC)-CPT-11 therapy].
abstract: We performed PMC-CPT-11 therapy (modified pharmacokinetic modulating chemotherapy plus irinotecan, or modified PMC) in a case of sigmoid colon cancer with local invasion and multiple hepatic metastases. This regimen combined PMC therapy which includes Hartmann's operation, simple hysterectomy and postoperative 5-fluorouracil (5-FU), with intravenous irinotecan, or CPT-11. The multiple hepatic metastatic lesions disappeared after surgery and no local recurrence has been found since. These results indicate that PMC-CPT-11 (modified PMC) therapy could be an effective regimen for cases of progressive colon cancer in the future.
authors.affiliation: Dept. of Surgery, Takarazuka Municipal Hospital.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Matsusaka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Oriyama
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Okada
authors.forename: Wooho
authors.initials: W
authors.lastname: Chang
authors.forename: Shigeto
authors.initials: S
authors.lastname: Maeda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kondo
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kosaka
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000493:pharmacokinetics; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D002166:Camptothecin / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000493:pharmacokinetics; D006499:Hepatic Artery; D006801:Humans; D007044:Hysterectomy; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000556:secondary*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012811:Sigmoid Neoplasms / Q000188:drug therapy / Q000473:pathology
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D005472:Fluorouracil; D002166:Camptothecin