title: [An elderly case of ANCA-positive membranous nephropathy].
abstract: We report a rare case of nephrotic syndrome in an elderly woman with positive antineutrophil cytoplasmic antibody(ANCA). The patient was 81 years of age and had a history of interstitial pneumonia. She was diagnosed rheumatoid arthritis(RA) at admission. Rapidly progressing renal damage was found with mild microscopic hematuria and positive ANCA. The renal biopsy findings indicated membranous nephropathy. Neither gold nor anti-rheumatic drugs had been previously administered. She may have had an RA-specific membranous nephropathy. Crescentic formation was not clear. With hematuria, the leukocyte infiltration in the capillary lumen and the change in epithelial cells of Bowman's capsules would be histological findings suggesting ANCA-associated nephritis. This is a rare report on membranous nephropathy in an RA patient with ANCA-associated nephritis.
authors.affiliation: Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Shizue
authors.initials: S
authors.lastname: Sekine
authors.forename: Wako
authors.initials: W
authors.lastname: Yumura
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Shinya
authors.initials: S
authors.lastname: Suganuma
authors.forename: Takako
authors.initials: T
authors.lastname: Onuki
authors.forename: Keiko
authors.initials: K
authors.lastname: Uchida
authors.forename: Akira
authors.initials: A
authors.lastname: Kawashima
authors.forename: Kazuho
authors.initials: K
authors.lastname: Honda
authors.forename: Kosaku
authors.initials: K
authors.lastname: Nitta
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nihei
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000150:complications; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D016919:Meningitis, Cryptococcal / Q000209:etiology; D009195:Peroxidase / Q000276:immunology; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D011239:Prednisolone; D009195:Peroxidase