[Tracheobronchial amyloidosis: apropos of 2 cases].
BACKGROUND
Tracheo-bronchial amyloidosis is an uncommon localized form of amyloidosis. We report two new cases.


METHODS
Two patients had developed expiratory dyspnea for several months. CT-scan and flexible bronchoscopy confirmed tracheal narrowing and a diagnosis of tracheo-bronchial amyloidosis was made by tissue biopsies. The immunohistochemical type was AL in one case, undetermined in the other case. There was no argument for systemic involvement. The two patients benefited from bronchoscopic dilatation. This treatment improved clinical symptoms and pulmonary function tests with a follow up of 12 and 18 months respectively.


CONCLUSIONS
Tracheo-bronchial amyloidosis is a localised form of amyloidosis with various respiratory symptoms. Diagnosis is made by CT-scan and flexible bronchoscopy that allows biopsies. Immunohistochemical type is more often AL. Recurrence, respiratory insufficiency and tracheo-bronchial metaplasia are the most important complications. Treatment consists of bronchoscopic dilatation or excision, and bronchoscopic laser-YAG. Pulmonary function testing allows precise follow-up.
Cazalets
C
C
Service de médecine interne, hôpital Sud, 16, boulevard de Bulgarie, BP 5612, 35056 Rennes, France.
Belleguic
C
C
Sost
G
G
Caulet-Maugendre
S
S
Kernec
J
J
Droz
D
D
Grosbois
B
B
D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D001706:Biopsy; D001980:Bronchi / Q000473:pathology; D001982:Bronchial Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D001999:Bronchoscopy; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D012129:Respiratory Function Tests; D014057:Tomography, X-Ray Computed; D014132:Trachea / Q000473:pathology; D014133:Tracheal Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy
Amylose trachéobronchique: à propos de deux cas.