Cytogenetic studies on Nigella sativa seeds extract and thymoquinone on mouse cells infected with schistosomiasis using karyotyping.
The protective effect of Nigella sativa seed extract and its main constituents thymoquinone (TQ) was studied on mouse cells infected with schistosomiasis. Bone marrow cells in the in vivo experiments and spleen cells in the in vitro one were used to evaluate the potentially protective effect of these natural compounds on the induction of chromosomal aberrations. Karyotyping of the mice cells illustrated that the main abnormalities were gaps, fragments and deletions especially in chromosomes 2, 6 and some in chromosomes 13 and 14. Both N. sativa extract and TQ were considered as protective agents against the chromosomal aberrations induced as a result of schistosomiasis.
Aboul-Ela
Ezzat I
EI
Department of Genetics and Cytology, National Research Center, Dokki, Cairo, Egypt. aboul_ela@hotmail.com
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D016227:Benzoquinones / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects / Q000469:parasitology*; D002869:Chromosome Aberrations / Q000187:drug effects; D002875:Chromosomes / Q000187:drug effects; D007621:Karyotyping; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D010938:Plant Oils / Q000378:metabolism*; D012552:Schistosomiasis / Q000188:drug therapy* / Q000635:transmission; D012639:Seeds / Q000737:chemistry; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000469:parasitology*; D029974:Carum
D000970:Antineoplastic Agents; D016227:Benzoquinones; D010936:Plant Extracts; D010938:Plant Oils; C104525:caraway oil; C003466:thymoquinone