[Selected parameters of the oxidative-antioxidative balance in children with chronic severe bronchial asthma].
The aim of this study was to evaluate the involvement of selected parameters of oxidative-antioxidative system in children with severe bronchial asthma. In our study the intensity of peroxide lipid oxidation was calculated by the contents of malonic dialdehyde in plasma. At the same time antioxidant activity was evaluated. The plasma contents of vitamin E and total antioxidant status were measured, as were activity of glutathione peroxidase and superoxide dismutase in blood. Our study was performed on 24 children treated for severe bronchial asthma. The control group consisted of 27 healthy children. The study has revealed that children suffering from bronchial asthma exhibit disturbances in the oxidative/antioxidative balance, manifested by increased oxidative activity and by changes in certain parameters of the antioxidative system. Our results support the theory of free radicals involvement in pathophysiology of severe bronchial asthma.
Postepski
J
J
Kliniki Pediatrii, Chorób Płuc i Reumatologii, Akademii Medycznej w Lublinie.
Tuszkiewicz-Misztal
E
E
Emeryk
A
A
Górnicka
G
G
Wawrzyszuk
M
M
D001249:Asthma / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors; D014810:Vitamin E / Q000097:blood
D015415:Biomarkers; D014810:Vitamin E; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
Ocena wybranych parametrów równowagi oksydacyjno-antyoksydacyjnej u dzieci chorych na przewlekła ciezka astme oskrzelowa.