title: Cytotoxic diterpenoids from Euphorbia pekinensis.
abstract: A new diterpenoid, named euphpekinensin, along with three known diterpenoids, was isolated from the roots of Euphorbia pekinensis for the first time and the structures were elucidated by spectral analysis. The 2D-NMR techniques such as 1H-1H COSY, HMQC, HMBC and NOESY spectra were mainly applied to determine the structure of the new diterpenoid. The four diterpenoids showed cytotoxic activity against human KB cells in vitro.
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China. lykong@jlonline.com
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Xian-Li
authors.initials: XL
authors.lastname: Wu
authors.forename: Zhi-Da
authors.initials: ZD
authors.lastname: Min
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal; D028481:Euphorbia; D005562:Formazans / Q000378:metabolism; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D013778:Tetrazolium Salts / Q000378:metabolism
chemical_list: D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D005562:Formazans; D010936:Plant Extracts; D013778:Tetrazolium Salts; C458619:euphpekinensin; C079782:MTT formazan