Bisxanthones from Hypericum japonicum: inhibitors of PAF-induced hypotension.
The CHCl3-soluble part (HJ) of the MeOH extract from Hypericum japonicum afforded new bisxanthones, jacarelhyperols A (1) and B (2). The structures were elucidated by spectral methods. These compounds and HJ showed significant inhibitory effects against PAF-induced hypotension by an in vivo evaluation method, which can reveal the pharmacological action of the test material.
Ishiguro
Kyoko
K
School of Pharmaceutical Sciences, Mukogawa Women's University, Koshien Kyuban-cho, Hyogo, Japan. ishiguro@mwu.mukogawa-u.ac.jp
Nagata
Satoko
S
Oku
Hisae
H
Yamaki
Masae
M
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004365:Drugs, Chinese Herbal; D020902:Hypericum; D007022:Hypotension / Q000139:chemically induced / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D010742:Phospholipid Ethers / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D014966:Xanthenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D044004:Xanthones
D004365:Drugs, Chinese Herbal; D010742:Phospholipid Ethers; D010936:Plant Extracts; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D014966:Xanthenes; D044004:Xanthones; C458659:isojacareubin; C458679:jacarelhyperol A; C458639:jacarelhyperol B; C037913:CV 3988; C009689:xanthone