Higher acyclic nitrogen containing deoxy sugar derivatives: a new lead in the generation of antimycobacterial chemotherapeutics.
Syntheses of higher acyclic nitrogen containing deoxy sugar derivatives via nitroaldol reaction of different nitroalkanes with 2,3-dideoxy-alpha,beta-unsaturated aldehydo sugars obtained from glycals namely acetylated glucal and galactal and their in vitro antimycobacterial activity are presented.
Pathak
Rashmi
R
Medicinal Chemistry Division, Central Drug Research Institute, -226001, Lucknow, India.
Shaw
Arun K
AK
Bhaduri
Amiya P
AP
Chandrasekhar
K V G
KV
Srivastava
Anil
A
Srivastava
Kishore K
KK
Chaturvedi
Vineeta
V
Srivastava
Ranjana
R
Srivastava
Brahm S
BS
Arora
Shalini
S
Sinha
Sudhir
S
D000107:Acetylation; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003837:Deoxy Sugars / Q000737:chemistry* / Q000494:pharmacology*; D006865:Hydrogenation; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000254:growth & development; D009584:Nitrogen / Q000032:analysis*; D013329:Structure-Activity Relationship
D000995:Antitubercular Agents; D003837:Deoxy Sugars; D009584:Nitrogen