title: Gastrinaemia, tissue gastrin concentration and G cell density in the antral mucosa of swine with and without gastric ulcer of the pars oesophagea.
abstract: Gastric ulcer of the pars oesophagea (GUPO) of the stomach, which occurs spontaneously in swine, is of unknown aetiology. Because gastrin is a potent secretagogue linked to acid secretion, this study was designed to investigate, in pigs with or without GUPO, (1) basal and food-stimulated serum gastrin concentrations, (2) the concentration of tissue gastrin, and (3) gastrin-producing (G) cell density in the antral mucosa. Sixty-four pigs (32 with, and 32 without ulceration) were studied. Antral mucosa was obtained immediately after slaughter for assessment of G-cell number and tissue gastrin concentration. The presence or absence of GUPO was not significantly associated with either of the parameters measured.
authors.affiliation: Department of Veterinary Medicine, Federal University of Viçosa, School of Medicine, Brazil.
authors.forename: J C P
authors.initials: JC
authors.lastname: Silva
authors.forename: J L
authors.initials: JL
authors.lastname: Santos
authors.forename: A J A
authors.initials: AJ
authors.lastname: Barbosa
mesh_terms: D000818:Animals; D002452:Cell Count / Q000662:veterinary; D004435:Eating; D004935:Esophageal Diseases / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D004947:Esophagus / Q000473:pathology; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D019863:Gastrin-Secreting Cells / Q000378:metabolism / Q000473:pathology*; D005755:Gastrins / Q000097:blood* / Q000378:metabolism; D011706:Pyloric Antrum / Q000473:pathology; D013276:Stomach Ulcer / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism / Q000473:pathology*
chemical_list: D005755:Gastrins