title: The flavonoid galangin inhibits the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia.
abstract: The flavonoid galangin inhibits the partially purified metallo-beta-lactamase from Stenotrophomonas maltophilia. The effect was not reversed by the addition of ZnCl(2) suggesting that the inhibitory effect is not related to metal chelation. The flavonoid quercetin also has some inhibitory effect against the enzyme. Using the crystal structure of the enzyme, a molecular modelling study predicts a possible orientation of galangin at the active site of the enzyme.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, Kuwait, Kuwait. denny@hsc.kuniv.edu.kw
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Denny
authors.forename: Peter A
authors.initials: PA
authors.lastname: Lambert
authors.forename: Patrick W J
authors.initials: PW
authors.lastname: West
mesh_terms: D004791:Enzyme Inhibitors / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology; D020615:Stenotrophomonas maltophilia / Q000201:enzymology*; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000737:chemistry / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D005419:Flavonoids; D065093:beta-Lactamase Inhibitors; C037032:galangin; D011794:Quercetin; C088032:beta-lactamase L1; D001618:beta-Lactamases