title: [Erythrocytic antigens and their relationship with bipolar disorder. Preliminary study].
abstract: There is a close relation between cellular antigens and several diseases. Due to this relation a study was made of the red cell antigen system in 40 patients with Bipolar Disease, who fulfill the diagnostic criteria established by the international classification of Mental Diseases (CIE-10) and 40 control subjects. Known methodology (Orthodiagnostic) was used for the following red cell antigens: ABO, Rh, Hr, MNSs, S, Kidd, Kell, Lewis, Duffy y U. A high prevalence was found in A, RhD, C, Duffy (Fya), Kidd (Jkb), S antigens (p < 0.05), while non significant differences were found in the other antigenic systems studied. It is important to note the close ubication of the locus of the genes, responsible for the antigens with high prevalence, and the susceptibility genes for the bipolar disease. Based in this study it is possible to conclude that persons presenting a high prevalence of the mentioned antigens could be more susceptible to develop the Bipolar Disease.
authors.affiliation: Departamento de Biofísica y Tecnología Biomédica, Universidad del Zulia, Maracaibo, Venezuela. J.E.W.M@telcel.net.ve
authors.forename: Jesús
authors.initials: J
authors.lastname: Weir-Medina
authors.forename: Zumara
authors.initials: Z
authors.lastname: Zuleta-Neuman
authors.forename: Maria
authors.initials: M
authors.lastname: Zavala-Ferrer
authors.forename: Lilia
authors.initials: L
authors.lastname: Meléndez-Nucette
authors.forename: Eligio
authors.initials: E
authors.lastname: Nucette-Ríos
authors.forename: Angel
authors.initials: A
authors.lastname: Brito
mesh_terms: D000328:Adult; D001324:Autoantigens / Q000097:blood*; D001714:Bipolar Disorder / Q000097:blood* / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D008875:Middle Aged
chemical_list: D001324:Autoantigens
vernacular_title: Antígenos de eritrocitos y su relación con el trastorno bipolar. Estudio preliminar.