Autologous thrombin for treatment of pseudoaneurysms.
Femoral pseudoaneurysms arise in up to 2% of patients after femoral cannulation for cardiac catheterisation. We used autologous thrombin for percutaneous obliteration of pseudoaneurysms occurring after catheterisation. We prepared autologous thrombin isolates from blood of ten patients with femoral pseudoaneurysms, and injected this solution into the pseudoaneurysms with duplex imaging guidance. We then assayed thrombin activity. All pseudoaneurysms were successfully thrombosed without substantial complications, although three patients needed a repeat procedure within 24 h. We have shown that autologous thrombin-induced thrombosis of pseudoaneurysms is reliable, simple, safe, and cheaper than commercial bovine or human thrombin, and avoids risks of anaphylaxis and contamination with prions.
Quarmby
John W
JW
Engelke
Christoph
C
Chitolie
Andrew
A
Morgan
Robert A
RA
Belli
Anna Maria
AM
D017541:Aneurysm, False / Q000188:drug therapy*; D005260:Female; D005263:Femoral Artery; D006801:Humans; D008297:Male; D008875:Middle Aged; D013917:Thrombin / Q000302:isolation & purification / Q000627:therapeutic use*; D016896:Treatment Outcome
D013917:Thrombin