Consideration of vaccination against the FSGS factor.
Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic disease in adults, and it is thought to be increasing in incidence. FSGS is often difficult to treat and even has a high propensity to relapse after transplant. Indeed, this suggests that there might be some circulating factor responsible for proteinuria ('FSGS factor'). Here I suggest that if and when the FSGS factor is found, vaccination against this factor might be a useful treatment modality for FSGS.
Altschuler
E L
EL
Brain and Perception Laboratory, University of California, San Diego, La Jolla 92093-0109, USA. ealtschuler@ucsd.edu
D000328:Adult; D001324:Autoantigens; D005923:Glomerulosclerosis, Focal Segmental / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D014611:Vaccination
D001324:Autoantigens; D007166:Immunosuppressive Agents