title: [Bronchopulmonary dysplasia and corticosteroid therapy].
abstract: Inflammation plays a major role in the pathogenesis of bronchopulmonary dysplasia of preterm infants. Having a strong anti-inflammatory effect, corticosteroids have been proposed in the management of this disease. Antenatal steroids protect the newborn against its development. Postnatal systemic administration of steroids reduces the duration of mechanical ventilation and oxygen therapy, but is associated with short term and long term adverse effects. Early administration of dexamethasone (before 7 days of life) reduces the incidence and the severity of chronic lung disease at 28 days of life and 36 weeks of post-conceptional age. Inhaled steroids are associated with less adverse effects than dexamethasone administration, but they are also less effective.
authors.affiliation: Service de Gynécologie Obstétrique B, unité de néonatologie, hôpital Charles Nicolle, boulevard 9 Avril, 1006 Tunis, Tunisie. Ahmed.Cherif@fmt.rnu.tn
authors.forename: A
authors.initials: A
authors.lastname: Chérif
authors.forename: Z
authors.initials: Z
authors.lastname: Marrakchi
authors.forename: S
authors.initials: S
authors.lastname: Chaouachi
authors.forename: S
authors.initials: S
authors.lastname: Boukef
authors.forename: R
authors.initials: R
authors.lastname: Sfar
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000367:Age Factors; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001997:Bronchopulmonary Dysplasia / Q000188:drug therapy* / Q000517:prevention & control / Q000628:therapy; D019819:Budesonide / Q000008:administration & dosage / Q000627:therapeutic use; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use; D007231:Infant, Newborn; D015201:Meta-Analysis as Topic; D010102:Oxygen Inhalation Therapy; D010919:Placebos; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012121:Respiration, Artificial; D012138:Respiratory Therapy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D010919:Placebos; D019819:Budesonide; D003907:Dexamethasone; D006854:Hydrocortisone
vernacular_title: Dysplasie broncho-pulmonaire et corticothérapie.