Regioselective synthesis of 3-alkynyl-5-bromo-2-pyrones via Pd-catalyzed couplings on 3,5-dibromo-2-pyrone.
[reaction: see text] 3,5-Dibromo-2-pyrone underwent facile Pd(0)-catalyzed coupling reactions with various alkynes to give rise to the corresponding 3-alkynyl-5-bromo-2-pyrones with good to excellent chemical yields and regioselectivity.
Lee
Jin-Hee
JH
Department of Chemistry, Hanyang University, Seoul 133-791, Korea.
Park
Jung-Sang
JS
Cho
Cheon-Gyu
CG