title: Allogeneic blood stem cell transplantation following non-myeloablative conditioning for hypereosinophilic syndrome.
abstract: A male patient with hypereosinophilic syndrome (HES) underwent an allogeneic blood stem cell transplantation from a female donor following non-myeloablative conditioning consisting of a 2 Gy dose of TBI and fludarabine 30 mg/m(2) intravenously on three days. Before transplantation 100% of the mitotic bone marrow cells of the patient showed a clonal karyotype abnormality. Three months after the transplantation eosinophilia had resolved and a chromosome analysis revealed normal female karyotype. The present study shows that stem cell transplantation after non-myeloablative conditioning may have curative potential for HES.
authors.affiliation: Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Juvonen
authors.forename: L
authors.initials: L
authors.lastname: Volin
authors.forename: A
authors.initials: A
authors.lastname: Koponen
authors.forename: T
authors.initials: T
authors.lastname: Ruutu
mesh_terms: D000328:Adult; D001773:Blood Cells / Q000637:transplantation; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000628:therapy*; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007621:Karyotyping; D008297:Male; D033581:Stem Cell Transplantation / Q000379:methods*; D018183:Transplantation Chimera; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents