[Experimental study on repair of bone defect in femoral head by enhanced autogenous bone combined with bone morphogenetic protein].
OBJECTIVE
To compare and evaluate the capability of pure autogenous bone and the enhanced autogenous bone combined with bone morphogenetic protein in bone repair of femoral head.


METHODS
Eighteen femoral heads of 9 dogs were drilled by trephine, 4 mm in diameter, followed by respective implantations of autogenous bone grafting (group B) and of the enhanced autogenous bone composite, combined with bone morphogenetic protein (group C), with the self-repair of bone defect as the control (group A). Three, six, nine weeks after the operation, radiological examination, computerized tomography, light and electronic microscopes were performed to investigate the bone healing of the defect in the femoral head.


RESULTS
In group A, it could be observed that there was hematoma organization and delayed woven bone formation in the 3rd week after operation, and there was little replacement of woven bone by bone trabecula in the 9th week; in group B, the autogenous bone implanted were dead in the 3rd week and maintained in situ in the 9th week; in group C, active new bone formation, either endochondral or intramembranous ossification, was found in the 3rd week and entire repair of the bone defect by bone trabecula in the 9th week after operation.


CONCLUSIONS
The enhanced autogenous bone combined with bone morphogenetic protein could promote reconstruction of the bone defect in femoral head, superior to pure autogenous bone which could provide a framework for the new bone formation.
Ying
Zhan-Hai
ZH
Department of Orthopedic Surgery, First Hospital of Xi'an, Jiaotong University, Xi'an, Shaanxi, P. R. China, 710061.
Wang
Kun-Zheng
KZ
Zhang
Shen-Rong
SR
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D001861:Bone Regeneration; D004285:Dogs; D005270:Femur Head / Q000187:drug effects / Q000473:pathology; D005271:Femur Head Necrosis / Q000188:drug therapy / Q000601:surgery*; D014182:Transplantation, Autologous / Q000379:methods*
D019485:Bone Morphogenetic Proteins