[Experimental study on induction of apoptosis of leukemic cells by Boswellia carterii Birdw extractive].
The purpose of the study was to investigate the apoptosis of leukemic cells induced by Boswellia Carterii Birdw(BCB). The target leukemia cell line HL60 and bone marrow leukemic cells from 30 acute non-lymphocytic leukemic(ANLL) patients (3 M1 11 M2a 10 M3 1 M4a 5 M5b) were studied. Apoptosis was detected by morphological observation, DNA electrophoresis, percentage of DNA fragmentation test and flow cytometric cell cycle analysis. It is concluded that BCB can induce apoptosis in ANLL cells and HL60 cells.
Qi
Z
Z
Research Laboratory of Hematology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Zhang
G
G
Zhu
W
W
D000293:Adolescent; D000328:Adult; D017209:Apoptosis / Q000187:drug effects*; D029743:Boswellia / Q000737:chemistry*; D002648:Child; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D018922:HL-60 Cells / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014407:Tumor Cells, Cultured
D004365:Drugs, Chinese Herbal