title: A fourth case of 8p11 myeloproliferative disorder transforming to B-lineage acute lymphoblastic leukaemia. A case report.
abstract: A 56-year-old male presented with inguinal lymphadenopathy and leucocytosis (WBC 98 x 10(9)/l). Bone marrow morphology showed myeloid hyperplasia, with eosinophilia. Cytogenetic analysis showed no evidence of the Philadelphia chromosome, and fluorescence in situ hybridisation studies for the BCR/ABL fusion were negative. All cells examined showed the t(8;13)(p11;q12) translocation. Six weeks after presentation, the disease progressed to an acute lymphoblastic leukaemia (ALL). The lymphoblasts were CD19/CD10 dual positive. Cytogenetic analysis again showed the t(8;13) translocation, with no additional abnormalities. There have been at least 14 reported cases of the t(8;13) myeloproliferative disorder to date, of which only 3 transformed to B-lineage ALL: our case is the 4th.
authors.affiliation: Department of Haematology, Birmingham Heartlands Hospital, Birmingham, UK.
authors.forename: M
authors.initials: M
authors.lastname: JabbarAl-Obaidi
authors.forename: N
authors.initials: N
authors.lastname: Rymes
authors.forename: P
authors.initials: P
authors.lastname: White
authors.forename: M
authors.initials: M
authors.lastname: Pomfret
authors.forename: H
authors.initials: H
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Starczynski
authors.forename: R
authors.initials: R
authors.lastname: Johnson
mesh_terms: D001854:Bone Marrow Cells / Q000473:pathology; D002051:Burkitt Lymphoma / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002882:Chromosomes, Human, Pair 13; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic