The carboxy terminus of simian virus 40 large T antigen is required to disrupt the yeast cell cycle.
Wild-type and J domain mutant simian virus 40 large T antigens alter the cell cycle and bud morphology of Saccharomyces cerevisiae. In contrast, yeast cells expressing mutant T antigen lacking the carboxy-terminal 150 aa exhibit normal morphology, indicating that this region of T antigen is required for cell cycle disruption.
Fewell
Sheara W
SW
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260,USA.
Markle
Dena M
DM
Brodsky
Jeffrey L
JL
D000952:Antigens, Polyomavirus Transforming / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000235:genetics; D013539:Simian virus 40 / Q000378:metabolism*
D000952:Antigens, Polyomavirus Transforming