title: Chromosomal aberrations in intravascular lymphomatosis.
abstract: Intravascular lymphomatosis (IVL) is a unique, disseminated type of malignant lymphoma. However, no detailed comparative study limited to the chromosomal aberrations of IVL has been reported, because IVL is extremely rare and difficult to diagnose while the patient is alive. We present here a case of IVL, and compare its karyotype with those of five cases of previously reported IVL. The accumulation of structural aberrations in chromosomes 1, 6, and 18, especially 1p (4 of 6 cases) and trisomy 18 (4 of 6 cases), were found in our comparative study of the B-cell lineage typical IVL. These chromosomal rearrangements must provide important information regarding the characteristics of cytogenetically associated with the cellular genetics of IVL.
authors.affiliation: First Department of Internal Medicine, Shinshu University School of Medicine, Nagano, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tsukadaira
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Okubo
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ogasawara
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Urushibata
authors.forename: Takayuki
authors.initials: T
authors.lastname: Honda
authors.forename: Ikuo
authors.initials: I
authors.lastname: Miura
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D008099:Liver / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008875:Middle Aged; D014314:Trisomy