Intraarticular synovial sarcoma confirmed by SYT-SSX fusion transcript.
A case of intraarticular synovial sarcoma arising in the knee verified by detection of the tumor-specific SYT-SSX fusion transcript is described. Although it is extremely rare, synovial sarcoma may occur entirely within a joint space. The molecular assay for detecting a tumor-specific chimeric gene is a valuable tool for diagnosis of soft tissue sarcoma, especially for diagnostically difficult cases and tumors in unusual locations.
Namba
Yoshifumi
Y
Department of Orthopaedic Surgery, Okayama Rosai Hospital, Okayama, Japan.
Kawai
Akira
A
Naito
Noriko
N
Morimoto
Yuki
Y
Hanakawa
Shiro
S
Inoue
Hajime
H
D019677:Artificial Gene Fusion; D014408:Biomarkers, Tumor / Q000235:genetics / Q000302:isolation & purification*; D002887:Chromosomes, Human, Pair 18; D005260:Female; D006801:Humans; D007719:Knee Joint; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000302:isolation & purification*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D014158:Transcription, Genetic; D014178:Translocation, Genetic
D014408:Biomarkers, Tumor; D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein