title: Evaluation of kryptor cardiac troponin I immunoassay.
abstract: METHODS
  Cardiac troponin I (cTnl) is well recognized as a specific marker for myocardial infarction. A fully automated, random access, fluorescent immunoassay for cTnl was evaluated in comparison with an established assay (Stratus cTnl) using samples from healthy subjects and from patients with cardiac disease.
  
  
  RESULTS
  The detection and precision were acceptable, and no interference was observed from bilirubin, triglycerides, haemoglobin, rheumatoid factor, drugs (aspirin, dopamine, digoxin) or heparin. Results on the Kryptor cTnl assay correlated with those on the Stratus II cTnI assay. The optimum Kryptor cTnl concentration for acute myocardial infarction was 0.63 microg/L, with a sensitivity of 89% [95% confidence interval (CI): 75.9-96.3] and specificity of 98.9% (95% CI: 93.9-99.8).
  
  
  CONCLUSIONS
  Kryptor cTnl immunoassay is suitable for use in the diagnosis of myocardial infarction.
authors.affiliation: Service de Biochimie et Hormonologie Hĵpital Tenon, Paris, France. guillaume.lefevre@tnn.ap-hop-paris.fr
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lefèvre
authors.forename: Hanafi
authors.initials: H
authors.lastname: Graïne
authors.forename: Karim
authors.initials: K
authors.lastname: Bakkouch
authors.forename: Eric
authors.initials: E
authors.lastname: Garbarz
authors.forename: Ginette
authors.initials: G
authors.lastname: Marlin
authors.forename: Pierre Louis
authors.initials: PL
authors.lastname: Michel
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Capeau
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D009206:Myocardium / Q000737:chemistry; D012680:Sensitivity and Specificity; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I