Ossifying fibromyxoid tumor of soft parts. Cytogenetic findings.
Ossifying fibromyxoid tumor (OFMT) of soft parts is a recently described, rare but morphologically distinctive soft tissue tumor. The histogenesis of this lesion remains uncertain, although several immunohistochemical and ultrastructural features suggest that it is an unusual neural tumor, possibly of Schwann cell origin. We report here a case of a malignant variant of OFMT that occurred in the foot of a 52-year-old man. The karyotype of a pulmonary metastasis exhibited the following complex numeric and structural aberrations:72 approximately 74,XXY,-5,+6,+del(8)(p21),del(9)(p22),+10,der(11)t(3;11)(p21;p15),del(12) (q13),der(13)t(5;13)(q13;q34),+18,+19,+20,-22 [cp10]. A kidney metastasis exhibited the following karyotypic abnormalities: 46,XY,add(3)(p11),+der(3)t(3;?;11)(3qter-->3p11::?::11q13-->11qter), -5,del(8)(p21),add(9)(q22),del(9)(p22),der(11)t(3;11)(p21;p15),del(12)(q13),+der(13)t(5;13) (q13;q34),-22. To our knowledge, this is the first reported case of OFMT in which clonal chromosomal aberrations have been shown.
Nishio
Jun
J
Department of Pathology, School of Medicine, Fukuoka University, Japan. nishio@minf.med.fukuoka-u.ac.jp
Iwasaki
Hiroshi
H
Ohjimi
Yuko
Y
Ishiguro
Masako
M
Isayama
Teruto
T
Naito
Masatoshi
M
Okabayashi
Hiroshi
H
Kaneko
Yasuhiko
Y
Kikuchi
Masahiro
M
D002869:Chromosome Aberrations; D018214:Fibroma, Ossifying / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics* / Q000556:secondary; D008175:Lung Neoplasms / Q000235:genetics* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology; D014960:X Chromosome / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics*