Getting a GRIP on liprins.
Two papers in this issue of Neuron add a new dimension to our understanding of liprin and LAR RPTP function during synapse formation. present evidence that Dliprin-alpha interacts with Dlar to regulate presynaptic morphogenesis of the Drosophila neuromuscular junction. demonstrate that mammalian liprin-alpha1 forms a complex with the PDZ protein GRIP and LAR in both pre- and postsynaptic compartments of hippocampal neurons and is required for the clustering of the GluR2 glutamate receptor in dendritic spines.
Baran
Renee
R
Department of Molecular, Cell & Developmental Biology, University of California-Santa Cruz, Santa Cruz, CA 95064, USA.
Jin
Yishi
Y
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology*; D018091:Receptors, AMPA / Q000378:metabolism; D013569:Synapses / Q000378:metabolism
D002352:Carrier Proteins; D029721:Drosophila Proteins; C491310:GRIP1 protein, human; C491307:Grip protein, Drosophila; D047908:Intracellular Signaling Peptides and Proteins; C490600:Liprin-alpha protein, Drosophila; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D018091:Receptors, AMPA