Pyrogenic reactions following gentamicin therapy: an alternative explanation.
A hypothesis is proposed, arguing that gentamicin administration in a single daily dose results in higher peak tissue concentration, marked bacteriolysis with endotoxin (ET) release and consequent ET-mediated febrile host responses, which resemble Jarisch-Herxheimer reactions.
Jaber
B L
BL
Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. bjaber@lifespan.org
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D001433:Bacteriolysis / Q000187:drug effects / Q000502:physiology; D004334:Drug Administration Schedule; D004731:Endotoxins / Q000378:metabolism / Q000633:toxicity; D005334:Fever / Q000139:chemically induced*; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D008954:Models, Biological
D000900:Anti-Bacterial Agents; D004731:Endotoxins; D005839:Gentamicins