Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling.
The paradigm that emerged from studies during the past decade established a central role for Jak-Stat (signal transducer and activator of transcription) signaling pathways in promoting the diverse cellular responses induced by interferon gamma (IFN-gamma). However, recent studies have shown that the IFN-gamma receptor activates additional signaling pathways and can regulate gene expression by Stat1-independent pathways. The diversity of gene-expression patterns mediated by Stat1-dependent and -independent mechanisms and the balance between these two pathways play an important role in the biological response to IFN-gamma.
Ramana
Chilakamarti V
CV
Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA. starkg@ccf.org
Gil
M Pilar
MP
Schreiber
Robert D
RD
Stark
George R
GR
D000818:Animals; D004268:DNA-Binding Proteins / Q000276:immunology*; D005347:Fibroblasts; D005786:Gene Expression Regulation; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D020411:Oligonucleotide Array Sequence Analysis; D050794:STAT1 Transcription Factor; D015398:Signal Transduction / Q000276:immunology*; D015534:Trans-Activators / Q000276:immunology*
D004268:DNA-Binding Proteins; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D015534:Trans-Activators; D007371:Interferon-gamma