Effect of feeding Cuminum cyminum fruits, Thymus vulgaris leaves or their mixture to rats.
Cuminum cyminum fruits and T. vulgaris leaves were fed to male Wistar rats at 2% or 10% of standard diet for 6 w. A mixture (5% +5%) of the 2 plants was also fed to rats for a similar period. Diets containing 2% C. cyminum fruits, 2% or 10% T. vulgaris leaves were not toxic to rats. Impairment of growth and enterohepatonephropathy were observed in the rats fed a diet containing 10% C. cyminum fruits. These changes were also seen in the rats fed the mixture of the 2 plants and were accompanied by leukopenia, anemia and increases in serum AST activity and urea and by decreased total protein and albumin levels.
Haroun
E M
EM
Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine King Saud University, Buraidah, Al-Qassim, Saudi Arabia.
Mahmoud
O M
OM
Adam
S E I
SE
D000284:Administration, Oral; D000818:Animals; D028527:Cuminum / Q000633:toxicity*; D004032:Diet; D004347:Drug Interactions; D005638:Fruit; D007668:Kidney / Q000473:pathology*; D007970:Leukopenia / Q000139:chemically induced; D008099:Liver / Q000473:pathology*; D008297:Male; D018515:Plant Leaves; D028321:Plant Preparations; D051381:Rats; D017208:Rats, Wistar; D046930:Thymus Plant / Q000633:toxicity*
D028321:Plant Preparations