title: Physical activity and lung cancer risk in male smokers.
abstract: We examined the association between physical activity and lung cancer in a prospective cohort of 27,087 male smokers, ages 50-69 years, enrolled in the Alpha-Tocopherol, Beta Carotene Cancer Prevention (ATBC) Study. After an average of 10 years of follow-up, 1,442 lung cancer cases were diagnosed. Cox proportional hazards models were used to estimate the relative risk (RR) and 95% confidence intervals (CI) of lung cancer associated with self-reported occupational and leisure-time activity, adjusted for age, supplement group, body mass index, cigarettes smoked daily, years of smoking, education, energy intake and vegetable intake. There were no associations between occupational, leisure-time or combined categories of physical activity with lung cancer risk; however, age appeared to modify the effect of leisure-time activity (p = 0.02). Within increasing quartiles of age, the RRs (CI) for men active in leisure time compared to sedentary men were 0.77 (0.54-1.09), 0.74 (0.57-0.95), 1.09 (0.89-1.33) and 1.03 (0.88-1.21). These data suggest that among smokers, neither occupational nor leisure-time activity is associated with lung cancer risk. There may, however, be some modest risk reduction associated with leisure activity among younger smokers. Published 2002 Wiley-Liss, Inc.
authors.affiliation: Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. COLBERTL@mail.nih.gov
authors.forename: Lisa H
authors.initials: LH
authors.lastname: Colbert
authors.forename: Terryl J
authors.initials: TJ
authors.lastname: Hartman
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Tangrea
authors.forename: Pirjo
authors.initials: P
authors.lastname: Pietinen
authors.forename: Jarmo
authors.initials: J
authors.lastname: Virtamo
authors.forename: Philip R
authors.initials: PR
authors.lastname: Taylor
authors.forename: Demetrius
authors.initials: D
authors.lastname: Albanes
mesh_terms: D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D004651:Employment; D015444:Exercise; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007899:Leisure Activities; D008019:Life Style; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011998:Recreation; D012307:Risk Factors