The gift of Gab.
Gab proteins, including mammalian Gab1, Gab2, Gab3, Drosophila DOS and Caenorhabditis elegans Soc1, comprise a growing family of scaffolding/docking molecules involved in multiple signaling pathways mediated by receptor tyrosine kinases (RTKs) and non-RTK receptors. This paper reviews the structure/function relationships of Gab proteins and their biological roles during normal growth, differentiation and development programs.
Liu
Yan
Y
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. yliu@fhcrc.org
Rohrschneider
Larry R
LR
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology*; D029721:Drosophila Proteins; D005136:Eye Proteins / Q000502:physiology; D015870:Gene Expression; D006801:Humans; D010750:Phosphoproteins / Q000502:physiology*; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology; D014443:Tyrosine / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; C100319:Dos protein, Drosophila; D029721:Drosophila Proteins; D005136:Eye Proteins; C098587:GAB1 protein, human; C490895:GAB2 protein, human; C490897:Gab1 protein, mouse; C490894:Gab2 protein, mouse; C443674:Gab3 protein, mouse; D010750:Phosphoproteins; C439708:soc-1 protein, C elegans; D014443:Tyrosine