[Microsomal epoxide hydrolase gene polymorphism and susceptibility to chronic obstructive pulmonary disease in Han nationality of North China].
OBJECTIVE
We investigated whether polymorphism in gene for microsomal epoxide hydrolase (mEH) has any bearing on individual susceptibility to the development of chronic obstructive pulmonary disease.


METHODS
The genotypes of 55 patients with COPD and 52 healthy smoking control subjects were tested with polymerase chain reaction followed by restriction fragment length polymorphism for mEH gene.


RESULTS
The frequency of polymorphic genotypes of mEH showed no difference between the COPD group and the control group. In COPD group mEH exon 3 homozygous wild-type, heterozygote and homozygous mutant was 27.3%, 27.3% and 45.5% respectively and exon 4 homozygous wild-type, heterozygote and homozygous mutant was 72.7%, 18.2% and 9.1% respectively.


CONCLUSIONS
Genetic polymorphism in mEH is not associated with development of COPD in Han nationality of North China.
Zhang
Rongbao
R
Department of Respiratory Medicine, People's Hospital, Peking University, Beijing 100044, China.
Zhang
Aizhen
A
He
Quanying
Q
Lu
Bingbing
B
D044466:Asian People / Q000235:genetics; D004851:Epoxide Hydrolases / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*; D012907:Smoking
D004851:Epoxide Hydrolases