title: Relationship between sleep and secretion of gonadotropin and ovarian hormones in women with normal cycles.
abstract: OBJECTIVE
  To monitor gonadotropin and ovarian hormone levels in relation to sleep duration in normally cycling women.
  
  
  METHODS
  Observational and cross-sectional study.
  
  
  METHODS
  Multicentric collaborative study.
  
  
  METHODS
  One hundred six healthy and normally cycling women, aged 19 to 44 years, with cycle lengths of 24 to 34 days.
  
  
  METHODS
  Follow-up during one to four consecutive cycles with daily urine collection.
  
  
  METHODS
  Urine concentrations of LH, FSH, estrone-3-glucuronide (E1-3-G), and pregnanediol-3-alpha-glucuronide (Pd-3alpha-G). Ultrasound determination of day of ovulation and estimation of sleep duration.
  
  
  RESULTS
  We found a significant association between FSH levels and sleep duration (P=.008). Follicle-stimulating hormone levels were 20% higher in long-time sleepers than in short-time sleepers. This association persisted whatever the age or the body mass index. There was no significant association between belonging to any group and LH, E1-3-G, or Pd-3alpha-G levels.
  
  
  CONCLUSIONS
  Our results suggest that sleep duration could be related to FSH levels, although the study design did not allow us to establish a causal relationship nor to explain the physiological basis of the observed relationship.
authors.affiliation: Département d'Information Médicale, Hospices Civils de Lyon, Lyon, France. sandrine.touzet@chu-lyon.fr
authors.forename: Sandrine
authors.initials: S
authors.lastname: Touzet
authors.forename: Muriel
authors.initials: M
authors.lastname: Rabilloud
authors.forename: Hans
authors.initials: H
authors.lastname: Boehringer
authors.forename: Enriqueta
authors.initials: E
authors.lastname: Barranco
authors.forename: René
authors.initials: R
authors.lastname: Ecochard
mesh_terms: D000328:Adult; D000375:Aging; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004967:Estrogens / Q000378:metabolism*; D004970:Estrone / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D005640:Follicle Stimulating Hormone / Q000652:urine; D006062:Gonadotropins / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000652:urine; D008597:Menstrual Cycle; D006080:Ovarian Follicle / Q000000981:diagnostic imaging; D010060:Ovulation; D011276:Pregnanediol / Q000031:analogs & derivatives* / Q000652:urine; D012890:Sleep / Q000502:physiology*; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D004967:Estrogens; D006062:Gonadotropins; C022270:pregnanediol-3 alpha-glucuronide; C015856:estrone-3-glucuronide; D004970:Estrone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D011276:Pregnanediol