title: Differences in Candida albicans adhesion to intact and denatured type I collagen in vitro.
abstract: An inhibition assay of Candida albicans adhesion to gelatin-immobilized membranes was compared with that to intact type I collagen-immobilized membranes using an arginine-glycine-aspartic acid (RGD) containing peptide. As compared with a protein-free membrane, gelatin and collagen significantly enhanced the adherence of C. albicans. The adhesion of the yeast to gelatin was significantly inhibited by the RGD peptides, but not by arginine-glycine-glutamic acid (RGE) peptides. In contrast, attachment to collagen was not inhibited by RGD peptides. These results suggest that the RGD sequence of gelatin and the integrin-like proteins of yeasts may be involved in adherence.
authors.affiliation: Department of Prosthetic Dentistry, Hiroshima University School of Dentistry, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8553, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Makihira
authors.forename: H
authors.initials: H
authors.lastname: Nikawa
authors.forename: M
authors.initials: M
authors.lastname: Tamagami
authors.forename: T
authors.initials: T
authors.lastname: Hamada
authors.forename: L P
authors.initials: LP
authors.lastname: Samaranayake
mesh_terms: D000268:Adhesiveness; D002176:Candida albicans / Q000187:drug effects / Q000502:physiology*; D024042:Collagen Type I / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry; D006801:Humans; D016023:Integrins / Q000502:physiology; D008567:Membranes, Artificial; D009842:Oligopeptides / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000502:physiology; D013499:Surface Properties
chemical_list: D024042:Collagen Type I; D016023:Integrins; D008567:Membranes, Artificial; D009842:Oligopeptides; D011971:Receptors, Immunologic; C112658:arginyl-glycyl-glutamic acid; C047981:arginyl-glycyl-aspartic acid; D005780:Gelatin