title: De novo design, synthesis, and in vitro evaluation of inhibitors for prokaryotic tRNA-guanine transglycosylase: a dramatic sulfur effect on binding affinity.
authors.affiliation: Laboratorium für Organische Chemie, ETH-Hönggerberg, HCI, 8093 Zürich, Switzerland.
authors.forename: Emmanuel A
authors.initials: EA
authors.lastname: Meyer
authors.forename: Ruth
authors.initials: R
authors.lastname: Brenk
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Castellano
authors.forename: Maya
authors.initials: M
authors.lastname: Furler
authors.forename: Gerhard
authors.initials: G
authors.lastname: Klebe
authors.forename: François
authors.initials: F
authors.lastname: Diederich
mesh_terms: D018360:Crystallography, X-Ray; D015195:Drug Design; D004405:Dysentery, Bacillary / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D010430:Pentosyltransferases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D011487:Protein Conformation; D017355:Zymomonas / Q000201:enzymology
chemical_list: D004791:Enzyme Inhibitors; D010430:Pentosyltransferases; C020837:queuine tRNA-ribosyltransferase