IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells.
The IRTA1 and IRTA2 genes encode immunoglobulinlike cell surface receptors expressed in B cells and involved in chromosome 1q21 translocations in B-cell malignancy. We have now characterized and comparatively analyzed the structure and expression pattern of the entire family of IRTA genes, which includes 5 members contiguously located on chromosome 1q21. The IRTA messenger RNAs are expressed predominantly in the B-cell lineage within discrete B-cell compartments: IRTA1 is specific to the marginal zone, IRTA2 and IRTA3 are found in the germinal center light zone and in intraepithelial and interfollicular regions, and IRTA4 and IRTA5 are expressed predominantly in the mantle zone. All IRTA genes code for transmembrane receptors that are closely related to Fc receptors in their most amino-terminal extracellular domains and that possess cytoplasmic domains containing ITIM (immunotyrosine inhibition motifs)- and, possibly, ITAM (immunotyrosine activation motifs)-like motifs. These structural features suggest that the IRTA receptors may play a role in regulating activation of normal B cells and possibly in the development of neoplasia.
Miller
Ira
I
Institute of Cancer Genetics and the Department of Pathology, Columbia University, New York, NY 10032, USA.
Hatzivassiliou
Georgia
G
Cattoretti
Giorgio
G
Mendelsohn
Cathy
C
Dalla-Favera
Riccardo
R
D000595:Amino Acid Sequence; D001402:B-Lymphocytes / Q000378:metabolism* / Q000473:pathology; D002451:Cell Compartmentation; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D017124:Conserved Sequence; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D011961:Receptors, Fc; D017452:Receptors, IgG / Q000235:genetics; D011971:Receptors, Immunologic; D016415:Sequence Alignment
C422179:FCRL2 protein, human; C457775:FCRL3 protein, human; C423544:FCRL4 protein, human; C432367:FCRL5 protein, human; C452186:FCRLA protein, human; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D011961:Receptors, Fc; D017452:Receptors, IgG; D011971:Receptors, Immunologic