title: Studies on the half life time of rat liver transfer RNA species.
abstract: The tRNA fraction, extracted from very high speed supernatant fluid, from livers of rats injected with 3H-orotic acid, attained maximum specific activity after a little over 24 hr and, thereafter, decayed with an apparent half life of 5 days. This behaviour of tRNA was indistinguishable from that of liver rRNA and the acid soluble pool. Chromatography of tRNA, doubly labelled during a period of short synthesis and of prolonged decay, on a BD cellulose column, indicated that individual tRNA species turn over at a constant rate with respect to one another.
authors.affiliation: Institut de Pathologie Moléculaire and Institut Pasteur, Paris, France
authors.forename: Jacques
authors.initials: J
authors.lastname: Hanoune
authors.forename: M K.
authors.initials: MK
authors.lastname: Agarwal