Genomic and funtional aspects of the rat MHC, the RT1 complex.
The major histocompatibility complex (MHC) plays a central role in controlling immune responsiveness, susceptibility to certain diseases and histo-incompatibility. A physical map of the complete rat MHC, the RTI complex, is presented based on a PAC clonal contig (RT1n haplotype). Expression profiling of various tissues of different inbred strains has been carried out for genes of the RT1-C/E/M region, and different types of variability of expression are shown. As an example of single gene analysis, the RT1-linked heat shock-inducible heat shock genes Hsp70-1 and Hsp70-2 have been studied. It is demonstrated that their gene products are able to increase lysability of target cells by cytotoxic T lymphocytes.
Dressel
R
R
Abteilung Immungenetik, Georg-August-Universität, Göttingen, Germany. eguenth@gwdg.de
Walter
L
L
Günther
E
E
D000818:Animals; D020869:Gene Expression Profiling; D016678:Genome; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics; D006649:Histocompatibility Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics* / Q000276:immunology; D051381:Rats
D018840:HSP70 Heat-Shock Proteins; D006649:Histocompatibility Antigens; C038353:histocompatibility antigens RT, rat