title: Total antioxidant status in non-insulin-dependent diabetes mellitus patients in Ghana.
abstract: Total antioxidant status (TAS) was measured in thirty-five (35) non-insulin-dependent diabetes mellitus (NIDDM) patients aged 40 to 65 (mean +/- SE 49.6 +/- 1.0) years. Patients were on diet and oral hypoglycaemic drug (Daonil) therapy with fasting plasma glucose (FPG) >7.8mmol/l. Similar measurements were carried out in thirty-four apparently healthy individuals within the same age range (mean + SE 46.3 +/- 1.1 years) and FPG <6.4 mmol/L. FPG was measured by glucose oxidase method and TAS by colorimetric method. Comparing the two groups, TAS was significantly reduced in the NIDDM patients (p<0.001). An inverse correlation between FPG and TAS suggests the existence of lower antioxidant defence in uncontrolled NIDDM. A good control of FPG accompanied with antioxidant therapy could help reduce free radical activity and minimise complications associated with increased free radical activity in diabetic patients.
authors.affiliation: Department of Chemical Pathology, University of Ghana Medical School, Accra, Ghana.
authors.forename: D K
authors.initials: DK
authors.lastname: Dosoo
authors.forename: S V
authors.initials: SV
authors.lastname: Rana
authors.forename: K
authors.initials: K
authors.lastname: Offe-Amoyaw
authors.forename: D
authors.initials: D
authors.lastname: Tete-Donkor
authors.forename: S Q
authors.initials: SQ
authors.lastname: Maddy
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D005869:Ghana; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D005609:Free Radicals