title: A conserved family of doublesex-related genes from fishes.
abstract: The sex-determining gene Mab-3 of C. elegans and the doublesex gene of Drosophila each contain a common DM domain and share a similar role. Human doublesex-related gene DMRT1 also encodes a conserved DM-related DNA-binding domain. We present here the amplification of a broad range of DM domain sequences from three fish species using degenerate PCR. Our results reveal unexpected complexity of the DM domain gene family in vertebrates.
authors.affiliation: Department of Genetics and Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072, P. R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Huang
authors.forename: Hanhua
authors.initials: H
authors.lastname: Cheng
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Guo
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Jianfang
authors.initials: J
authors.lastname: Gui
authors.forename: Rongjia
authors.initials: R
authors.lastname: Zhou
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D017124:Conserved Sequence / Q000235:genetics*; D004268:DNA-Binding Proteins; D004524:Eels / Q000235:genetics; D005260:Female; D005399:Fishes / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D019849:Sex Determination Processes; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics*; D015027:Zebrafish / Q000235:genetics; D029961:Zebrafish Proteins
chemical_list: C110547:DMRT1 protein; C119852:DMRT2 protein, human; D004268:DNA-Binding Proteins; D014157:Transcription Factors; D029961:Zebrafish Proteins; C486539:dmrt2a protein, zebrafish