[Effect of nitric oxide on HSV-1 infection of HeLa cells and Vero-E6 cells].
The effects of nitric oxide(NO) on HSV-1 infection of HeLa cell line and Vero-E6 cell line were investigated in this study. The titers of HSV-1 in supernatants from infected culture of Vero-E6 cells were decreased by a NO donor, sodium nitroprusside(SNP), in a dose-dependent manner, while the control compound potassium ferricyanide (KFC) had no effect. However, SNP had no effect on that of HeLa cells. The results reaffirm the antiviral effect of NO and suggest that the susceptibility of different cell lines to the effect of NO might be varied.
Liu
S
S
Department of Microbiology, Hunan Medical University, Changsha 410078.
Shu
M
M
Xiao
Y
Y
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D006367:HeLa Cells / Q000821:virology; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000254:growth & development*; D006801:Humans; D009569:Nitric Oxide / Q000494:pharmacology*; D014709:Vero Cells / Q000821:virology
D000998:Antiviral Agents; D009569:Nitric Oxide