title: Fatal hepatic failure after emergence of the hepatitis B virus mutant during lamivudine therapy in a patient with liver cirrhosis.
abstract: Lamivudine therapy for chronic hepatitis and decompensated liver cirrhosis related to the hepatitis B virus (HBV) resulted in improvement of liver function and inhibition of viral replication. Despite emergence of the HBV mutant, e-antigen seroconversion and improvement of liver function may be achieved with continuation of lamivudine therapy. Although hepatic decompensation has been reported in a few cases after the emergence of lamivudine-resistant mutants, fatal cases of non-transplant patients have only rarely been reported in the literature. Here, we describe a patient with HBV-related liver cirrhosis who died after a breakthrough infection with a lamivudine-resistant mutant. Hepatic failure and mortality developed after flare-up of severe hepatitis after 13 months of lamivudine treatment. Emergence of the HBV mutant with substitution of isoleucine for leucine at residue 426 (L4261) in combination with isoleucine for methionine at residue 550 (M5501) was observed at 10 and 13 months of treatment.
authors.affiliation: Dept. of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan.
authors.forename: J H
authors.initials: JH
authors.lastname: Wang
authors.forename: S N
authors.initials: SN
authors.lastname: Lu
authors.forename: C M
authors.initials: CM
authors.lastname: Lee
authors.forename: J F
authors.initials: JF
authors.lastname: Lee
authors.forename: Y P
authors.initials: YP
authors.lastname: Chou
mesh_terms: D001483:Base Sequence; D004279:DNA, Viral / Q000097:blood*; D004352:Drug Resistance, Microbial; D017809:Fatal Outcome; D006515:Hepatitis B virus / Q000187:drug effects* / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage*; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000821:virology; D017093:Liver Failure / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage*
chemical_list: D004279:DNA, Viral; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine