title: Postoperative development of children after hemispherotomy.
abstract: We studied the postoperative development of 14 children with cortical dysgenesis who underwent modified functional hemispherectomy (hemispherotomy) at the age of 6 years or younger. At follow-up of 24-72 months (median of 47 months), six (43%) were seizure-free, six achieved>90% reduction, one achieved 50-90% reduction, and one achieved 0-50% reduction in seizure frequency. At the preoperative and final postoperative examinations, mean scores of developmental quotient (DQ) were as follows: 25.5 and 31.9 in total DQ, 26.0 and 33.7 in intellectual DQ, and 27.4 and 22.9 in motor DQ. Children scoring >50 points in preoperative intellectual DQ score obtained near-normal intellectual DQ postoperatively, while, those scoring <10 DQ preoperatively remained at a low developmental level. Among children with DQ scores in the range from 10 to 50, two children who obtained seizure-free outcome and were operated upon in the first 3 years of life achieved marked developmental progress. The present study indicated that high preoperative intellectual DQ and cessation of seizures seem to be associated with better postoperative intellectual development. However, long-term observation of postoperative development and an accumulation of more cases will be needed before we can reach a firm conclusion.
authors.affiliation: Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu-shi, 183-0042 Tokyo, Japan. maehara.nsrg@tmd.ac.jp
authors.forename: Taketoshi
authors.initials: T
authors.lastname: Maehara
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kawai
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Shigetomo
authors.forename: Kimiko
authors.initials: K
authors.lastname: Tamagawa
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Yamada
authors.forename: Mari
authors.initials: M
authors.lastname: Inoue
mesh_terms: D002540:Cerebral Cortex / Q000002:abnormalities* / Q000601:surgery*; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D004827:Epilepsy / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007360:Intelligence; D008297:Male; D009043:Motor Activity; D011184:Postoperative Period