[Study on lumbricus in promoting ligation hemorrhoidectomy postoperative wound healing].
OBJECTIVE
To investigate the effect of Lumbricus in promoting wound healing of ligation hemorrhoidectomy.


METHODS
Spray the artificial grown fresh Lumbricus solution on the wound surface of the mixed hemorrhoid patients (treated group) after hemorrhoidectomy and also on wound of the experimental animals, and Lithospermum erythrorhizon medicated gauze was taken as control to observe the effect of treatment on wound healing and histologic change.


RESULTS
The mean wound healing time of the treated group was 16.5 +/- 1.8 days, as compared to the control group (21.2 +/- 2.8 days), it was obviously shortened (P < 0.01), 3 days after medication, the growth of epidermis of the treated group was obviously more rapid than that of the control group, no wound infection and granulation hyperplasia were found. The experimental study showed that Lumbricus preparation could inhibit inflammation, bacteria such as Staphylococcus aureus, coli and proteus bacillus was inhibited. In comparison with the control group, the experimental group shortened the healing period for 4 days. On the 4th and 7th day, sacrificed rabbits' capillary count, vessel lumen endothelial cell count, and mesenchymal fibroblast count of the experimental group grower obviously than those of the control group, on the 4th day, the mesenchymal cell mitosis of the experimental group was higher than that of the control group, while on the 7th day, the cell nucleus mitotic index in the experimental group also was higher than that in the control group, from the 3rd day on, wound healing and granulation filling speed of the experimental group obviously more rapid than that of the control group.


CONCLUSIONS
The Lumbricus preparation is cheap in price, easy to preserve, can be used in promoting wound healing, without any toxic and side-effects.
Li
D
D
Beijing Municipal Erlonglu Hospital, Beijing 100032.
Wang
P
P
Zeng
Y
Y
D000328:Adult; D000818:Animals; D005260:Female; D006484:Hemorrhoids / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008419:Materia Medica; D051379:Mice; D008875:Middle Aged; D009835:Oligochaeta / Q000737:chemistry; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
D008419:Materia Medica