title: Electrospray mass spectrometry for fumonisin detection and method validation.
abstract: Fumonisins are a structurally related group of mycotoxins, characterized by a 19-20 carbon aminopolyhydroxy-alkyl chain which is diesterified with propane-1,2,3-tricarboxylic acid (tricarballylic acid). These mycotoxins are commonly found in corn and corn-based food products and have been linked to a variety of animal toxicities. The widespread prevalence of fumonisins and the toxicity associated with ingestion has resulted in a number of analytical methods for determining the amount of fumonisins present in foods. Among the most common of these methods are liquid chromatographic (LC) separation with fluorescence detection, enzyme-linked immunosorbent assay (ELISA) and LC/mass spectrometry. LC and ELISA give quantitative results while LC/MS provide quantitative analysis as well as confirmation of identity of the fumonisins.
authors.affiliation: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC 20204, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Musser
authors.forename: Robert M
authors.initials: RM
authors.lastname: Eppley
authors.forename: Mary W
authors.initials: MW
authors.lastname: Trucksess
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004797:Enzyme-Linked Immunosorbent Assay; D005670:Fusarium / Q000737:chemistry; D009183:Mycotoxins / Q000032:analysis*; D012015:Reference Standards; D015203:Reproducibility of Results; D021241:Spectrometry, Mass, Electrospray Ionization; D014233:Tricarboxylic Acids / Q000032:analysis; D003313:Zea mays / Q000737:chemistry
chemical_list: D009183:Mycotoxins; D014233:Tricarboxylic Acids