title: Antiinflammatory activity of rotenoids from Clitoria fairchildiana.
abstract: Five structurally related rotenoids were isolated from the roots of Clitoria fairchildiana. The antiinflammatory activity was investigated using a capillary permeability assay. The protective effect was measured as the inhibition in vascular permeability produced by acetic acid in the peritoneal cavity. The results suggest that for maximum activity the maintenance of the B/C ring junction integrity is important. These findings support the traditional use of Clitoria species extracts in the treatment of inflammatory conditions.
authors.affiliation: Núcleo de Pesquisas de Produtos Naturais, Centro de Ciencias da Saúde, Universidade Federal do Rio de Janeiro, 21944-970, PO Box 68045, Brazil.
authors.forename: Bernadete
authors.initials: B
authors.lastname: Pereira da Silva
authors.forename: José
authors.initials: J
authors.lastname: Paz Parente
mesh_terms: D019342:Acetic Acid; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects*; D007887:Fabaceae; D006801:Humans; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D012402:Rotenone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D012402:Rotenone; C052364:clitoriacetal; D019342:Acetic Acid