[Magnetic resonance proton spectroscopy in neurooncology--preliminary report].
MR proton spectroscopy (1H MRS) has been widely applied in characterisation and differentiation of brain tumors, staging, recurrence of pathologic process, post radiotherapy changes and other lesions mimicking neoplasm like abscesses. Despite of many studies performed over last 3 years in many countries spectroscopic pattern (phenotype) of brain tumors is still not well estimated and the role of each metabolite as an indicator of histopathologic grade and type of the tumor is still unknown.


METHODS
In vivo 1H MR spectroscopy was prospectively performed in 36 patients with intracranial tumors (low grade gliomas, high grade gliomas, meningiomas and abscesses). Examinations was performed with 1.5 T system, using voxels of 8 cc.


RESULTS
In high grade gliomas level of NAA was decreased, and consequently low ratios of NAA to other metabolites were obtained; lactate and choline peaks were markedly increased. In patients with meningiomas signal of NAA was reduced, while in abscesses group peaks of acetate and succinate were observed. Authors analysed ratios of metabolites in above-mentioned tumors. The method is especially useful in differential diagnosis in neoplastic and nonneoplastic cases.


CONCLUSIONS
Our study confirms diagnostic value of 1H MRS in doubtful cases of intracranial tumors.
Kubas
B
B
Zakładu Radiologii AM w Białymstoku.
Tarasów
E
E
Dzienis
W
W
Łebkowski
W
W
Zimnoch
L
L
Dziecioł
J
J
Siergiejczyk
L
L
Walecki
J
J
Lewko
J
J
D001922:Brain Abscess / Q000175:diagnosis* / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005910:Glioma / Q000175:diagnosis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008577:Meningeal Neoplasms / Q000175:diagnosis; D008579:Meningioma / Q000175:diagnosis; D011446:Prospective Studies; D011522:Protons; D012680:Sensitivity and Specificity
D011522:Protons
Spektroskopia protonowa rezonansu magnetycznego w neuroonkologii--doświadczenia wstepne.