title: [Primary thyroid lymphomas: clinicopathologic study of 30 cases and review of the literature].
abstract: During a both retrospective and prospective study of thyroid cancers treated in the Basse Normandie between 1960 and 1999, we have identified 32 patients with thyroid lymphoma. The correct diagnosis was made initially in 69% of all cases. In the other cases, the diagnosis was secondarily corrected after review of the pathological material. According to the REAL classification, 7 (21%) corresponded to low grade MALT lymphomas, 2 to low grade lymphomas, 10 to high grade MALT Lymphomas and 10 (31%) to high grade lymphomas, one plasmocytoma and two unclassified lymphomas. According to the Ann Arbor classification, stage was IE for 56%, IIE for 19%, IIIE for 3% and 9% for IV. Median survival was 28 months with a mean at 61 months. 20 patients died (62%), 12 from the lymphoma and 8 from intercurrent causes. The overall survival at 5 years was 36% (9 5% CI 16 54%). A comparison of our results with those of the literature was performed.
authors.affiliation: Service d'Anatomie Pathologique, Centre Francois Baclesse, 14076 Caen Cedex, France.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Michels
authors.forename: Corinne
authors.initials: C
authors.lastname: Delcambre
authors.forename: Jacques
authors.initials: J
authors.lastname: Marnay
authors.forename: Yves
authors.initials: Y
authors.lastname: Denoux
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Peny
authors.forename: Jacques
authors.initials: J
authors.lastname: Chasle
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010954:Plasmacytoma / Q000175:diagnosis / Q000473:pathology; D011379:Prognosis; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy
vernacular_title: Lymphomes thyroïdiens primitifs: étude clinico-pathologique de 30 cas et revue de la littérature.