title: Synthesis of 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate.
abstract: [reaction: see text] The synthesis of 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate, a biochemical intermediate in the deoxyxylulose pathway of isoprenoid biosynthesis, was accomplished in four steps. Bisphosphorylation of 2-C-methyl-D-erythritol 1,3-diacetate, followed by carbodiimide cyclization and deprotection, led to the title compound in 42% overall yield.
authors.affiliation: Department of Chemistry, State University of New York-ESF, Syracuse, New York 13210, USA. jlginer@syr.edu
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Giner
authors.forename: William V
authors.initials: WV
authors.lastname: Ferris
mesh_terms: D003500:Cyclization; D004896:Erythritol / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy
chemical_list: D007202:Indicators and Reagents; C073443:2-methyl-butan-1,2,3,4-tetraol-2,4-cyclopyrophosphate; D004896:Erythritol