title: Sequential MRI in a case of Creutzfeldt-Jakob disease.
abstract: A 48-year-old man suddenly developed clinically and electroencephalographically nonspecific dementia. On MRI sequences, only diffusion-weighted images (DWI) of the cortex were unequivocally pathological. Obvious atrophy and basal ganglia signal changes appeared only 9 months after the onset. Brain biopsy confirmed Creutzfeldt-Jakob disease (CJD). In rapidly progressive dementia, we recommend DWI for early diagnosis of CJD.
authors.affiliation: Universitätsklinik für Neurologie, Allgemeines Krankenhaus Wien, Währinger Gürtel, Vienna, Austria. Gotthard.Trivl@akh-wien.ac.at
authors.forename: G G
authors.initials: GG
authors.lastname: Tribl
authors.forename: G
authors.initials: G
authors.lastname: Strasser
authors.forename: J
authors.initials: J
authors.lastname: Zeitlhofer
authors.forename: S
authors.initials: S
authors.lastname: Asenbaum
authors.forename: C
authors.initials: C
authors.lastname: Jarius
authors.forename: P
authors.initials: P
authors.lastname: Wessely
authors.forename: D
authors.initials: D
authors.lastname: Prayer
mesh_terms: D001921:Brain / Q000473:pathology*; D003287:Contrast Media; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D004569:Electroencephalography; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA