title: Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor.
abstract: Cholecystokinin (CCK) is an important gastrointestinal hormone as well as a neurotransmitter. Two types of CCK receptors, types A and B, have been identified. The CCK-A receptor is involved in satiety, food intake and behavior, whereas the B receptor is involved in anxiety. We recently produced CCK-A, -B and AB receptor knockout mice to study the role of these receptors in energy metabolism. Daily energy intake and expenditure were significantly greater in CCK-BR(-/-) and CCK-AR(-/-)BR(-/-) mice than CCK-AR(-/-) and wild-type [CCK-AR(+/+)BR(+/+)] mice. Relative liver and kidney weights (g/kg body) were significantly greater in CCK-AR(-/-)BR(-/-) mice than in wild-type mice. Energy metabolism and energy turnover were increased in mice with a disruption of the CCK-BR gene, although the underlying mechanism is unknown.
authors.affiliation: Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo-173-0015, Japan. miyasaka@tmig.or.jp
authors.forename: Kyoko
authors.initials: K
authors.lastname: Miyasaka
authors.forename: Mineko
authors.initials: M
authors.lastname: Ichikawa
authors.forename: Minoru
authors.initials: M
authors.lastname: Ohta
authors.forename: Setsuko
authors.initials: S
authors.lastname: Kanai
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Masao
authors.initials: M
authors.lastname: Masuda
authors.forename: Aki
authors.initials: A
authors.lastname: Nagata
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Matsui
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Noda
authors.forename: Soichi
authors.initials: S
authors.lastname: Takiguchi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takata
authors.forename: Takako
authors.initials: T
authors.lastname: Kawanami
authors.forename: Akihiro
authors.initials: A
authors.lastname: Funakoshi
mesh_terms: D000818:Animals; D002149:Energy Intake; D004734:Energy Metabolism / Q000235:genetics*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009929:Organ Size / Q000235:genetics; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin / Q000172:deficiency*
chemical_list: D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin