title: [Diminution of the in vitro and in vivo alloreactive response by association of mature dendritic cells and anti-CD4 monoclonal antibodies in the rat].
abstract: Using a fully mismatched model recipient Lewis-donor Wistar-Furth rats, we showed that the association donor mature (spleen) dendritic cells with a non depleting anti-CD4 monoclonal antibody can induce a more pronounced decrease of alloreactivity in mixed splenocyte reaction than anti-CD4 alone. These results are observed in vitro and 30 days after injection to the Lewis rats. Such data suggest that anti-CD4 monoclonal antibody can guide mature dendritic cells, usually involved in acute rejection, towards tolerance. The mechanisms are still to be resolved.
authors.affiliation: Laboratoire Immunomanipulation et immunosuppresseurs en allo et auto-immunité, UPRES-EA 563, CHU Le Bocage, 2, boulevard Maréchal de Lattre de Tassigny, 21034 Dijon.
authors.forename: I
authors.initials: I
authors.lastname: Simoneau-Robin
authors.forename: C
authors.initials: C
authors.lastname: Mousson
authors.forename: J
authors.initials: J
authors.lastname: Wijdenes
authors.forename: G
authors.initials: G
authors.lastname: Rifle
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism*; D015704:CD4 Antigens / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D006084:Graft Rejection; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011920:Rats, Inbred WF; D013154:Spleen / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D007519:Isoantigens
vernacular_title: Diminution de la réponse alloréactive in vitro et in vivo par association de cellules dendritiques matures du donneur et d'un anticorps monoclonal anti-CD4 chez le rat.