title: A cost-effectiveness evaluation of amlodipine usage in patients with coronary artery disease in Sweden.
abstract: The objective of this analysis was to calculate the cost-effectiveness of amlodipine therapy in patients with coronary artery disease in Sweden. It is hypothesised that treatment with amlodipine will have an impact on overall cardiovascular disease treatment costs, resulting in a positive cost-effectiveness profile. A Markov cohort simulation model was constructed to simulate event-related and procedure-related health economic outcomes of coronary artery disease populations on amlodipine versus those on placebo. Patient level data from the Prospective Evaluation of the Vascular Effects of Norvasc Trial was used to populate the model. The total number of adverse cardiovascular clinical outcomes experienced over a three-year period was lower for patient on amlodipine than for those on placebo. The rate of hospitalisation per patient due to angina, coronary artery bypass graft, percutaneous transluminal coronary angioplasty, congestive heart failure, and myocardial infarction in the placebo cohort was 64.7%, while the rate in the amlodipine cohort was 46.9%. The cost per patient was Swedish kroner (SEK)26,600 for amlodipine patients and SEK27,400 for placebo patients. The use of amlodipine resulted in improved clinical outcomes as well as a slight savings in cost over a three-year period.
authors.affiliation: The Analytica Group, New York, NY 10016, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Doyle
authors.forename: A
authors.initials: A
authors.lastname: McGuire
authors.forename: R
authors.initials: R
authors.lastname: Arocho
authors.forename: S
authors.initials: S
authors.lastname: Arikian
authors.forename: J
authors.initials: J
authors.lastname: Casciano
authors.forename: P
authors.initials: P
authors.lastname: Svangren
authors.forename: R
authors.initials: R
authors.lastname: Casciano
authors.forename: R
authors.initials: R
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Kugel
mesh_terms: D017311:Amlodipine / Q000191:economics* / Q000627:therapeutic use; D000704:Analysis of Variance; D002121:Calcium Channel Blockers / Q000191:economics* / Q000627:therapeutic use; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000191:economics*; D003362:Cost-Benefit Analysis; D006801:Humans; D008390:Markov Chains; D017059:Models, Econometric; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013548:Sweden
chemical_list: D002121:Calcium Channel Blockers; D017311:Amlodipine