title: CJ-21,058, a new SecA inhibitor isolated from a fungus.
abstract: A new equisetin derivative, CJ-21,058 (I) was isolated from the fermentation broth of an unidentified fungus CL47745. It shows antibacterial activity against Gram-positive multi-drug resistant bacteria by inhibiting ATP-dependent translocation of precursor proteins across a bacterial cell membrane.
authors.affiliation: Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. Yutaka.Sugie@japan.pfizer.com
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sugie
authors.forename: Sae
authors.initials: S
authors.lastname: Inagaki
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Kato
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nishida
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Pang
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Saito
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sakemi
authors.forename: Fadia
authors.initials: F
authors.lastname: Dib-Hajj
authors.forename: John P
authors.initials: JP
authors.lastname: Mueller
authors.forename: Joyce
authors.initials: J
authors.lastname: Sutcliffe
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kojima
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009281:Naphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011760:Pyrrolidinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013764:Tetrahydronaphthalenes
chemical_list: D000900:Anti-Bacterial Agents; C451492:CJ 21058; D009281:Naphthalenes; D011760:Pyrrolidinones; D013764:Tetrahydronaphthalenes; C024509:equisetin