[Oxygen and the superoxide anion. Modulation of NADPH oxidase?].
Oxidative stress which results from an imbalance between oxidant production and antioxidant defense mechanisms can promote modifications of lipids, proteins and nucleic acids. This review focuses on the different pathways leading to Reactive Oxygen Species (ROS) production in particular on NADPH oxidase activation. This enzyme is localized in numerous cells including phagocytes and vascular cells and composed of membrane and cytosolic sub-units. The activation of the NADPH oxidase is largely involved in inflammation associated diseases such as asthma, Systemic Inflammatory Response Syndrome and aging associated diseases such as atherosclerosis and neurodeneratives diseases. The modulation of NADPH oxidase could be a way to limit or prevent the development of these diseases.
Delbosc
S
S
Laboratoire de Biochime, Laboratoire de Biochimie et Biologie des Lipides, Institut Universitaire de Recherche Clinique, Montpellier, France.
Cristol
J P
JP
Descomps
B
B
Chénard
J
J
Sirois
P
P
D000838:Anions; D001161:Arteriosclerosis / Q000201:enzymology / Q000517:prevention & control; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000201:enzymology / Q000517:prevention & control; D019255:NADPH Oxidases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000201:enzymology / Q000517:prevention & control; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D013481:Superoxides / Q000378:metabolism*; D013812:Therapeutics
D000838:Anions; D004791:Enzyme Inhibitors; D017382:Reactive Oxygen Species; D013481:Superoxides; D019255:NADPH Oxidases
De l'oxygène à l'anion superoxyde. Peut-on moduler la NADPH oxydase?