Lewis acid promoted phenylseleno group transfer tandem radical cyclization reactions.
[reaction: see text] A new Lewis acid promoted phenylseleno group transfer tandem radical cyclization method was developed. In the presence of Lewis acids such as Yb(OTf)3 or Mg(ClO4)2, under photolysis condition at low temperature (-45 degrees C), various unsaturated alpha-phenylseleno beta-keto amides underwent radical cyclization reactions to give monocyclic or bicyclic products in a highly efficient, regioselective, and stereoselective manner.
Yang
Dan
D
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. yangdan@hku.hk
Gao
Qiang
Q
Lee
On-Yi
OY