title: Risk of positive margins and biochemical recurrence in relation to nerve-sparing radical prostatectomy.
abstract: OBJECTIVE
  To assess the effect of nerve-sparing (NS) radical retropubic prostatectomy (RRP) on surgical margins and biochemical recurrence.
  
  
  METHODS
  Location and incidence of positive surgical margins, recurrence, and time to recurrence were assessed in a consecutive series of 734 men who underwent RRP for localized prostate cancer from 1992 through February 2000. NS procedures were used in 33% (n = 240) of 734 patients studied.
  
  
  RESULTS
  Surgical margins were positive for 24% (n = 58) and 31% (n = 152) of NS and non-NS patients, respectively (P =.06). No significant difference between the groups was found in location of positive margins (P =.92). Prostate-specific antigen level greater than 10 ng/mL, extraprostatic extension, tumor volume more than 20%, capsular penetration, Gleason score > or = 7, positive margins, and seminal vesicle invasion were associated with significantly increased risk of recurrence. However, NS patients were not at increased risk of recurrence compared with non-NS patients (hazard ratio, 0.96; 95% confidence interval, 0.53 to 1.72). The cumulative risk of recurrence within 3 and 5 years of surgery in NS patients was 9.7% and 14.4%, respectively, as compared with 17.1% and 21.1% for non-NS patients.
  
  
  CONCLUSIONS
  In patients with localized prostate cancer, neither margin status nor biochemical-free survival within 5 years of surgery were altered by the nerve preservation technique. Given our experience, we recommend preservation of neurovascular bundles in these patients whenever the procedure is technically feasible.
authors.affiliation: Department of Urology, University of Miami, FL 33101, USA.
authors.forename: Mario
authors.initials: M
authors.lastname: Sofer
authors.forename: Kara L
authors.initials: KL
authors.lastname: Hamilton-Nelson
authors.forename: James J
authors.initials: JJ
authors.lastname: Schlesselman
authors.forename: Mark S
authors.initials: MS
authors.lastname: Soloway
mesh_terms: D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000276:immunology; D009367:Neoplasm Staging; D016017:Odds Ratio; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D012306:Risk; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D017430:Prostate-Specific Antigen