title: Predictors of recurrent restenosis after coronary stenting: an analysis of 197 patients.
abstract: One of the major limitations in coronary stenting is in-stent restenosis. This study was aimed to identify clinical, angiographic, and procedural factors that may be related to recurrent in-stent restenosis. We analyzed consecutive 197 patients who underwent coronary stenting. Follow-up angiography was available in 170 patients and repeat balloon angioplasty was performed for in-stent restenosis. These patients were subdivided into 3 groups: group A consisted of 100 patients that were never restenosed, group B had 49 patients restenosed once, and in group C were 21 patients restenosed more than twice. Group C was more often female (48%) and included diabetes mellitus patients (52%). Lesion location, reference vessel size and diameter stenosis were similar for all groups. However, the incidence of calcified lesions tended to be higher (50% vs. 29%; p = 0.07), and lesion length was longer in group C than in group A (11.9+/- 5.4 mm vs. 9.0+/- 3.9 mm; p < 0.01). Diameter stenosis after predilation as well as after stenting was significantly higher in group C than in group A (50+/- 10% vs 39+/- 10%; p < 0.01, 32+/- 8% vs. 19+/- 10%; p < 0.01). The incidence of diffuse type of in-stent restenosis was significantly higher in group C than in group B (62% vs. 14%; p < 0.01). Multivariate logistic regression analysis identified diameter stenosis after stenting (p = 0.0022), female (p = 0.0135), and diameter stenosis after predilatation (p = 0.0233) as the significant correlate of recurrent in-stent restenosis. In conclusion, the major recurrent in-stent restenosis predictors identified included female gender, final diameter stenosis, and diameter stenosis after predilatation.
authors.affiliation: Division of Cardiology, Tokushima Red Cross Hospital, Shinbiraki 28-1, Chuden-cho, Komatsushima, Tokushima, Japan, 773-8502. ptcaman@tokushima-med.jrc.or.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Kishi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Hiasa
authors.forename: Naoki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Takefumi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Shinobu
authors.initials: S
authors.lastname: Hosokawa
authors.forename: Masato
authors.initials: M
authors.lastname: Tanimoto
authors.forename: Ryuji
authors.initials: R
authors.lastname: Otani
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors; D012737:Sex Factors; D015607:Stents