Long-term survival after gene therapy for a recurrent glioblastoma.
A patient presenting with a recurrent glioblastoma (GBM) survived 3 years after suicide gene therapy and finally died of a disseminated breast cancer with no indication of tumor recurrence on MRI. Postmortem analysis showed no evidence of recurrence of the GBM, neither near the initial tumor localization nor in any other area of the brain. Such an evolution is unusual in the course of this disease and may suggest in this particular case a cure of the GBM.
Valéry
C A
CA
Department of Neurosurgery, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Seilhean
D
D
Boyer
O
O
Marro
B
B
Hauw
J-J
JJ
Kemeny
J-L
JL
Marsault
C
C
Philippon
J
J
Klatzmann
D
D
D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D015316:Genetic Therapy / Q000379:methods / Q000706:statistics & numerical data; D005909:Glioblastoma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D017741:Survivors / Q000706:statistics & numerical data