[Antidotal effects of vitamin B(6) and sodium dimercaptopropane sulfonate on acute poisoning with tetramethylene disulphotetramine in animals].
OBJECTIVE
The study was designed to examine the antidotal effects of vitamin B(6) (Vit B(6)) with sodium dimercaptopropane sulfonate (Na-DMPS) on acute poisoning with tetramethylene disulphotetramine (TETS) in animals.


METHODS
Through the acute toxicity experiments, the antidotal effects of Vit B(6) with Na-DMPS on mice immediately and 10 minutes after poisoning were observed.


RESULTS
Used of Vit B(6) with Na-DMPS in early stage showed excellent inhibition of tetanic convulsion in acute poisoning with TETS in mice and can reduce very significantly the death rate (P < 0.001). Vit B(6) with Na-DMPS used 10 minutes after poisoning also significantly elongate the death time (68.8 +/- 15.2) and reduce significantly the death rate (60%) then control group's death time (31.6 +/- 7.8) and the death rate (100%) on acute poisoning in mice (P < 0.01).


CONCLUSIONS
Antidotal effects of Vit B(6) with Na-DMPS were significant on acute TETS poisoning in animals. Vit B(6) with Na-DMPS is an excellent antidote for acute TETS poisoning. It is suggested that Vit B(6) with Na-DMPS may be clinically used to rescue patients poisoned by TETS.
Qiu
Zewu
Z
The Department of Emergency, Beijing 307 Hospital, Beijing 100039, China.
Lan
Hong
H
Zhang
Shaohua
S
Xia
Yadong
Y
Huang
Shaoqing
S
D000208:Acute Disease; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001952:Bridged-Ring Compounds / Q000506:poisoning*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D014494:Unithiol / Q000627:therapeutic use*; D025101:Vitamin B 6 / Q000627:therapeutic use*
D000931:Antidotes; D001952:Bridged-Ring Compounds; D014494:Unithiol; D025101:Vitamin B 6; C010349:tetramethylenedisulfotetramine