Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again.
Cell migration is an integrated process that requires the continuous, coordinated formation and disassembly of adhesions. These processes are complex and require a regulated interaction of numerous molecules, and the activation of specific signalling pathways. Even though understanding these processes is challenging, important insights are beginning to emerge, and the technology to facilitate significant advances in this area is now in place.
Webb
Donna J
DJ
Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA. djw2p@virginia.edu
Parsons
J Thomas
JT
Horwitz
Alan F
AF
D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D003584:Cytological Techniques; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D006160:Guanosine Triphosphate; D020741:rho GTP-Binding Proteins