Antiinflammatory activity of rotenoids from Clitoria fairchildiana.
Five structurally related rotenoids were isolated from the roots of Clitoria fairchildiana. The antiinflammatory activity was investigated using a capillary permeability assay. The protective effect was measured as the inhibition in vascular permeability produced by acetic acid in the peritoneal cavity. The results suggest that for maximum activity the maintenance of the B/C ring junction integrity is important. These findings support the traditional use of Clitoria species extracts in the treatment of inflammatory conditions.
Pereira da Silva
Bernadete
B
Núcleo de Pesquisas de Produtos Naturais, Centro de Ciencias da Saúde, Universidade Federal do Rio de Janeiro, 21944-970, PO Box 68045, Brazil.
Paz Parente
José
J
D019342:Acetic Acid; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects*; D007887:Fabaceae; D006801:Humans; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D012402:Rotenone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D012402:Rotenone; C052364:clitoriacetal; D019342:Acetic Acid