[Study on relationship between estrogen receptor gene polymorphism and syndrome differentiation typing of female postmenopausal osteoporosis in Traditional Chinese medicine].
OBJECTIVE
To study the relationship between estrogen gene polymorphism and TCM Syndrome Differentiation of female postmenopausal osteoporosis in China.


METHODS
Two hundred and forty-six Chinese postmenopausal women, age 44-80 years, mean 65.8 years, using molecular biological method to analyze the endonuclease Pvu II, Xba I restriction fragment length polymorphisms (RFLPs), with dual X-ray bone mineral density absorption meter to determine the bone mineral densities of lumbar vertebra (L1-4) and femur (intertrochanter, femur neck, Ward's region) separately. The subjects were divided into Kidney Yin deficiency type, Kidney Yang deficiency type and both Kidney Yin-Yang deficiency type, to observe the relationship between TCM and bone density as well as estrogen receptor gene polymorphism, Pp(Pvu II) and Xx(Xba I) were used to express RFLPs, the capital P and X to express the deficit of restricting sites.


RESULTS
Bone mineral density of PPxx gene type (n = 21) was obviously lower than that of other gene types (n = 225), lumbar (-0.71 +/- 0.46) g/cm2, intertrochanter (-0.31 +/- 0.58) g/cm2, femur neck (-0.84 +/- 0.66) g/cm2, Ward's region (-0.96 +/- 0.85) g/cm2, the TCM Syndrome Differentiation typing of this gene type belonged to both Kidney Yin-Yang deficiency type.


CONCLUSIONS
Estrogen receptor gene RFLPs is related to TCM Syndrome Differentiation typing.
An
S
S
Integrated TCM and WM Basic Theory Department, Hebei Medical University, Shijiazhuang 050017.
Li
E
E
Tong
X
X
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000145:classification / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011960:Receptors, Estrogen / Q000235:genetics*; D016711:Yang Deficiency / Q000235:genetics; D016710:Yin Deficiency / Q000235:genetics
D011960:Receptors, Estrogen