title: [Electrophysiological study of 5,6-dihydroxytryptamine effect on defensive reflex conditioning in the snail].
abstract: The role of serotonin in expression of membrane properties of identified neurons was studied during defensive reflex conditioning using the neurotoxic analogue of serotonin 5,6-dihydroxytryptamine (5,6-DHT). The defensive reflex conditioning in snails was destroyed on the second day after second injection of 5,6-DHT. Through the 1st weeks after second injection of 5,6-DHT the snails were learned but worse than snails after injection of saline solution. This result shows the recovery of snail's learning ability within 2 weeks after the second injection of 5,6-DHT. It was found that injection of 5,6-DHT prevented the decrease of membrane and threshold potentials of command neurons during defensive reflex conditioning as compared with the snails injected with 5,6-DHT without learning.
authors.affiliation: Kazan Physical-Technical Institute, Russian Acad. Sci., 420029, Kazan-29, 10/7 Sibirsky Trakt.
authors.forename: T Kh
authors.initials: TKh
authors.lastname: Gaĭnutdinova
authors.forename: V V
authors.initials: VV
authors.lastname: Andrianov
authors.forename: Kh L
authors.initials: KhL
authors.lastname: Gaĭnutdinov
mesh_terms: D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D001245:Association Learning / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D004924:Escape Reaction / Q000187:drug effects*; D017952:Ganglia, Invertebrate / Q000187:drug effects / Q000502:physiology; D006372:Helix, Snails; D066298:In Vitro Techniques; D008564:Membrane Potentials; D018490:Serotonin Agents / Q000494:pharmacology*
chemical_list: D018490:Serotonin Agents; D015115:5,6-Dihydroxytryptamine
vernacular_title: Electrophysiologicheskie issledovaniia vliianiia 5,6-digidroxytriptamina na vyrabotku uslovnogo oboronitel'nogo refleksa u ulitki.