Synthesis of N-protected peptide alcohols catalyzed by subtilisin or alpha-chymotrypsin in organic solvents.
A series of N-protected peptide alcohols were synthesized using amino alcohols with unprotected hydroxy groups as amino components by the catalysis of subtilisin or alpha-chymotrypsin in organic solvents. N-protected aromatic amino acid esters were more suitable as acyl donors for subtilisin. The influences of different N-protecting groups, organic solvents, and content of water on synthesis of N-protected peptide alcohols were systematically studied.
Liu
Ping
P
Ministry of Education, Department of Chemistry, Peking University, Beijing, P R, China.
Tian
Gui-Ling
GL
Lo
Wai-Hung
WH
Lee
Kin-Sing
KS
Ye
Yun-Hua
YH
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D002384:Catalysis; D002919:Chymotrypsinogen / Q000378:metabolism*; D009904:Optical Rotation; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D020860:Subtilisin / Q000378:metabolism*; D014867:Water / Q000737:chemistry
D000438:Alcohols; D012997:Solvents; D014867:Water; D002919:Chymotrypsinogen; D020860:Subtilisin