title: Production of BRO beta-lactamases and resistance to complement in European Moraxella catarrhalis isolates.
abstract: Of the 419 Moraxella catarrhalis isolates collected during the 1997-1999 European SENTRY surveillance study, 385 (92%) were beta-lactamase positive. Twenty-two (5.7%) produced BRO-2 beta-lactamase. Twenty-one new mutations were found in the putative promoter region of the bro genes. Nineteen percent of all isolates tested were complement sensitive. Resistance to beta-lactams is not linked to the phylogenetic lineages associated with susceptibility to complement.
authors.affiliation: Institute for Medical Microbiology and Virology, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany. schmitfj@uni-duesseldorf.de
authors.forename: Franz-Josef
authors.initials: FJ
authors.lastname: Schmitz
authors.forename: Andreas
authors.initials: A
authors.lastname: Beeck
authors.forename: Mirella
authors.initials: M
authors.lastname: Perdikouli
authors.forename: Mechthild
authors.initials: M
authors.lastname: Boos
authors.forename: Susanne
authors.initials: S
authors.lastname: Mayer
authors.forename: Sybille
authors.initials: S
authors.lastname: Scheuring
authors.forename: Karl
authors.initials: K
authors.lastname: Köhrer
authors.forename: Jan
authors.initials: J
authors.lastname: Verhoef
authors.forename: Ad C
authors.initials: AC
authors.lastname: Fluit
mesh_terms: D003165:Complement System Proteins / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005060:Europe; D006801:Humans; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D016870:Neisseriaceae Infections / Q000382:microbiology*; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D047090:beta-Lactams; D003165:Complement System Proteins; C408134:BRO beta-lactamase; D001618:beta-Lactamases