Intracranial germinoma with syncytiotrophoblastic giant cells in the cerebellopontine angle--case report.
A 23-year-old man presented with a 3-week history of left hearing disturbance and left facial nerve paresis. T1-weighted magnetic resonance (MR) imaging showed an iso-intense mass in the left cerebellopontine angle (CPA), with homogeneous enhancement with gadolinium-diethylenetriaminepenta-acetic acid. T2-weighted MR imaging showed the mass as heterogeneously iso- to hyperintense. Gross total removal of the tumor was achieved. Histological examination revealed that the tumor was a germinoma with syncytiotrophoblastic giant cells. Whole central nervous system irradiation with cisplatin-etoposide chemotherapy was performed postoperatively. He has been in good condition with no sign of recurrence for 7 years. Intracranial germ cell tumors in the CPA are very rare. Total surgical removal followed by irradiation and chemotherapy will provide a good outcome.
Fujiwara
Kazunori
K
Department of Neurosurgery, Sendai National Hospital, Sendai, Japan. kfujiwara-nsu@umin.ac.jp
Uenohara
Hiroshi
H
Suzuki
Hiroyoshi
H
Sakurai
Yoshiharu
Y
D000328:Adult; D002528:Cerebellar Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D002530:Cerebellopontine Angle / Q000473:pathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003399:Craniotomy; D018237:Germinoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D008297:Male; D018714:Radiotherapy, Adjuvant