Networks and crosstalk: integrin signalling spreads.
Multicellular organisms must coordinate signals from adhesion receptors with those from other signalling receptors (for example, growth factor receptors). Here, we briefly review paradigms of integrin-adhesion-receptor signalling. We discuss how adhesive signalling is coordinately regulated through intersecting networks. We also examine some examples of how some forms of integrin crosstalk may lead to unforeseen and potentially deleterious responses.
Schwartz
Martin A
MA
Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. schwartz@scripps.edu
Ginsberg
Mark H
MH
D000818:Animals; D002455:Cell Division; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D010766:Phosphorylation; D017978:Receptors, Growth Factor / Q000378:metabolism; D015398:Signal Transduction
D016023:Integrins; D017978:Receptors, Growth Factor