title: [Intermittent-pulse treatment of onychomycosis with orally administered itraconazole].
abstract: Fifty-four patients received an intermittent regimen of itraconazole (26 of them were finger onychomycosis and 28 toe onychomycosis) and were followed-up for nine months. The result showed that the clinical cure rate of fingernails was 88.5% and the mycologic cure rate was 96.4%, while the clinical cure rate of toes was 82.1% and the mycologic cure rate was 96.4%. Few adverse events were observed by 7.4%, just like nausea, gastric discomfort etc. It suggests that the pulse administration system is highly effective and has a few side-effects.
authors.affiliation: Department of Dermatology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
authors.forename: L
authors.initials: L
authors.lastname: Yan
authors.forename: H
authors.initials: H
authors.lastname: Wen
authors.forename: Y
authors.initials: Y
authors.lastname: Zhong
authors.forename: C
authors.initials: C
authors.lastname: Cao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005533:Foot Dermatoses / Q000188:drug therapy; D006229:Hand Dermatoses / Q000188:drug therapy; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D014009:Onychomycosis / Q000188:drug therapy*; D020551:Pulse Therapy, Drug
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole