title: Hyperbaric oxygen therapy and osteoradionecrosis.
abstract: Osteoradionecrosis of the mandible is a potentially devastating complication of head and neck radiation. Radiation causes progressive vascular occlusion with tissue hypoxia, tissue death, and failure of healing. Hyperbaric oxygen therapy is an accepted treatment for osteoradionecrosis. This article reviews the history of hyperbaric oxygen therapy, its physiologic mechanisms, its use in the management of osteoradionecrosis, and its complications and contraindications.
authors.affiliation: University of Iowa College of Medicine, Department of Anesthesia, Division of Hyperbaric Medicine, Iowa City, IA 52242, USA.
authors.forename: B R
authors.initials: BR
authors.lastname: Porter
authors.forename: J E
authors.initials: JE
authors.lastname: Brian
mesh_terms: D000075202:Contraindications; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000009:adverse effects / Q000379:methods; D008336:Mandibular Diseases / Q000628:therapy*; D010025:Osteoradionecrosis / Q000628:therapy*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology; D010313:Partial Pressure; D011878:Radiotherapy / Q000009:adverse effects
chemical_list: D010100:Oxygen