Commentary on neostigmine interactions with non steroidal anti-inflammatory drugs by Miranda et al.
The article by Miranda et al. presents data showing significant synergism between NEO and certain NSAIDs administered i.p. in the mouse. Their conclusions follow from isobolar analysis accompanied by statistical confidence limits that show significant differences between the additive (expected) and experimental potencies. This commentary discusses the features of the graphical method of analysis and points out other experimental designs and the methods used to analyse them.
Tallarida
Ronald J
RJ
Temple University School of Medicine, Philadelphia, Pennsylvania, PA 19140, USA.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004357:Drug Synergism; D051379:Mice; D023421:Models, Animal; D009388:Neostigmine / Q000494:pharmacology*; D010147:Pain Measurement
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002800:Cholinesterase Inhibitors; D009388:Neostigmine