title: Implementation of the DOTS strategy for tuberculosis in the Leningrad Region, Russian Federation (1998-1999).
abstract: METHODS
  The DOTS pilot project for tuberculosis control in the Leningrad Region of the Russian Federation, supported by the Finnish Lung Health Association and the World Health Organization (WHO).
  
  
  OBJECTIVE
  To assess the efficacy of WHO-recommended standard short-course chemotherapy in newly detected pulmonary tuberculosis cases positive by smear or with extensive lung lesions suggestive of culture positivity, under project conditions.
  
  
  METHODS
  Analysis of data on case detection, sputum smear conversion and treatment outcome based on standardised (WHO) registers from districts and a central computerised database.
  
  
  RESULTS
  Of 859 adult pulmonary tuberculosis cases (292 smear-positive) notified in the Leningrad Region in the study period, 312 new cases were included in the project. The sputum conversion rate at the end of the second month was 82.8% and 91.1% at the end of the third month. Of bacteriologically confirmed cases, 71.3% were successfully treated, 4.9% died, 11.7% defaulted and 8.1% failed.
  
  
  CONCLUSIONS
  In the first year of the pilot project in the Leningrad Region, the DOTS strategy revealed feasibility and moderate efficacy among new pulmonary tuberculosis cases who were either smear-positive or showed extensive lung lesions on chest X-ray, and who were therefore of high epidemiological and medical priority.
authors.affiliation: Finnish Lung Health Association, Helsinki. rauni.ruohonen@filha.fi
authors.forename: R P
authors.initials: RP
authors.lastname: Ruohonen
authors.forename: T M
authors.initials: TM
authors.lastname: Goloubeva
authors.forename: L
authors.initials: L
authors.lastname: Trnka
authors.forename: M M
authors.initials: MM
authors.lastname: Fomin
authors.forename: G A
authors.initials: GA
authors.lastname: Zhemkova
authors.forename: A V
authors.initials: AV
authors.lastname: Sinitsyn
authors.forename: A A
authors.initials: AA
authors.lastname: Lichachev
authors.forename: K G
authors.initials: KG
authors.lastname: Koskela
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D023801:Directly Observed Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010865:Pilot Projects; D015397:Program Evaluation; D012426:Russia; D013183:Sputum / Q000382:microbiology; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D014944:World Health Organization
chemical_list: D000995:Antitubercular Agents