[Relationship of age, sex, body weight, smoking, blood lipids and fibrinolytic activities in healthy subjects].
Relationship of plasma activities of tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor-1(PAI-1) with age, sex, body weight, smoking, blood lipids were studied in 131 healthy subjects. The results demonstrated that plasma PAI-1 activity increased with age and body weight. PAI-1/t-PA ratio was higher in smoking than in non-smoking subjects. With multivariate analyses, plasma PAI-1 activity was positively correlated with age, body weight index(BMI) in males, and positively correlated with low-density-lipoprotein-cholesterol(LDL) in females, and negatively correlated with plasma tPA activity. Plasma triglyceride, high-density-lipoprotein-cholesterol did not show a correlation to PAI-1 or tPA activity. It is indicated that age, BMI, blood lipids may contribute to moderate fibrinolytic activities and that smoking may affect fibrinolytic function.
Xiong
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X
Department of Cardiovascular Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Wang
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Z
Zhao
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D000328:Adult; D000367:Age Factors; D000368:Aged; D001835:Body Weight; D005260:Female; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D012016:Reference Values; D012907:Smoking; D010959:Tissue Plasminogen Activator / Q000097:blood*
D008077:Lipoproteins, LDL; D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator