title: Tuning rate of the bergman cyclization of benzannelated enediynes with ortho substituents.
abstract: [reaction: see text] The Bergman cyclization of benzannelated enediynes is highly sensitive to ortho substitution. This finding opens possibilities for the rational design of conformer-specific and pH-dependent DNA-cleaving agents.
authors.affiliation: Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306-4390, USA. alabugin@chem.fsu.edu
authors.forename: Igor V
authors.initials: IV
authors.lastname: Alabugin
authors.forename: Mariappan
authors.initials: M
authors.lastname: Manoharan
authors.forename: Serguei V
authors.initials: SV
authors.lastname: Kovalenko
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D003500:Cyclization; D004247:DNA / Q000737:chemistry*; D008968:Molecular Conformation
chemical_list: D000480:Alkynes; D004247:DNA