title: Improved method for the quality assurance of [C-11]choline.
abstract: [C-11]choline is a very promising radiomarker for the diagnosis of various human tumors using Positron Emission Tomography (PET). The existing quality control process for [C-11]choline is complicated and combines two HPLC methods with limited separation and sensitivity which prevent the accurate determination of the specific activity. We have developed a new efficient single HPLC method for the detection of choline chloride and dimethylaminoethanol with high resolution and sensitivity using cation-exchange chromatography.
authors.affiliation: Hebrew University, Hadassah Hospital, Department of Medical Biophysics and Nuclear Medicine, Il-91120, Jerusalem, Israel. mishani@md2.huji.ac.il
authors.forename: E
authors.initials: E
authors.lastname: Mishani
authors.forename: I
authors.initials: I
authors.lastname: Ben-David
authors.forename: Y
authors.initials: Y
authors.lastname: Rozen
mesh_terms: D002794:Choline / Q000737:chemistry* / Q000592:standards; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003642:Deanol / Q000737:chemistry; D011786:Quality Control; D019275:Radiopharmaceuticals / Q000737:chemistry* / Q000592:standards; D012015:Reference Standards; D012996:Solutions
chemical_list: D019275:Radiopharmaceuticals; D012996:Solutions; D003642:Deanol; D002794:Choline