HIV-1 transcription: activation mediated by acetylation of Tat.
Acetylation of HIV-1 Tat stimulates transcriptional elongation by dissociating Tat from TAR, a transactivation response RNA element in nascent HIV-1 transcripts. In the March issue of Molecular Cell, Mujtaba et al. show that the bromodomain of PCAF acetylase specifically binds to acetylated Tat and leads to dissociation of Tat from TAR.
Nakatani
Yoshihiro
Y
Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D015696:Gene Products, tat / Q000378:metabolism*; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics*; D051548:Histone Acetyltransferases; D006801:Humans; D008957:Models, Genetic; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D014158:Transcription, Genetic; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D029701:Saccharomyces cerevisiae Proteins; D054322:tat Gene Products, Human Immunodeficiency Virus; D000123:Acetyltransferases; D051548:Histone Acetyltransferases