Rasmussen's encephalitis: a role for autoimmune cytotoxic T lymphocytes.
The present review describes advances in Rasmussen's encephalitis (also known as Rasmussen's syndrome), an unihemispheric intractable epileptic disease with persistent inflammation. Specific attention is given to the recent recognition of cytotoxicity by CD8+/granzyme-B-positive T lymphocytes as a new pathogenic mechanism of neuronal damage.
Bauer
Jan
J
Brain Research Institute, Division of Neuroimmunology, University of Vienna, Vienna, Austria.
Bien
Christian G
CG
Lassmann
Hans
H
D000906:Antibodies / Q000276:immunology; D020274:Autoimmune Diseases of the Nervous System / Q000276:immunology* / Q000473:pathology; D004660:Encephalitis / Q000209:etiology* / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D009474:Neurons / Q000378:metabolism; D018091:Receptors, AMPA / Q000276:immunology / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism
D000906:Antibodies; D018091:Receptors, AMPA; C104723:glutamate receptor ionotropic, AMPA 3