Study on the interaction of ions of transient metals with ascorbic acid in the presence of different scavengers of active oxygen species in SOS chromotest.
SOS chromotest was employed to study the interaction of ascorbic acid with free ions of transient metals in the presence of added catalase, superoxide dismutase or D-mannitol. Catalase diminished the genotoxic activity of the mixture of ascorbic acid with copper ions in E. coli strains PQ37 and PQ 300, but genotoxicity of this mixture was not suppressed by superoxide dismutase and D-mannitol. The results suggest that copper ions diminished the content of peroxide generated by ascorbic acid.
Marczewska
Jadwiga
J
Department of Vitamins, Drug Institute, Warsaw, Poland.
Koziorowska
Jadwiga H
JH
D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D003300:Copper / Q000633:toxicity*; D004347:Drug Interactions; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D005290:Ferric Compounds / Q000633:toxicity; D016166:Free Radical Scavengers / Q000378:metabolism*; D008353:Mannitol / Q000378:metabolism; D009153:Mutagens / Q000633:toxicity; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species; D013014:SOS Response, Genetics; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D005290:Ferric Compounds; D016166:Free Radical Scavengers; D009153:Mutagens; D017382:Reactive Oxygen Species; C024823:ferric sulfate; D008353:Mannitol; D003300:Copper; D002374:Catalase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid