Production of BRO beta-lactamases and resistance to complement in European Moraxella catarrhalis isolates.
Of the 419 Moraxella catarrhalis isolates collected during the 1997-1999 European SENTRY surveillance study, 385 (92%) were beta-lactamase positive. Twenty-two (5.7%) produced BRO-2 beta-lactamase. Twenty-one new mutations were found in the putative promoter region of the bro genes. Nineteen percent of all isolates tested were complement sensitive. Resistance to beta-lactams is not linked to the phylogenetic lineages associated with susceptibility to complement.
Schmitz
Franz-Josef
FJ
Institute for Medical Microbiology and Virology, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany. schmitfj@uni-duesseldorf.de
Beeck
Andreas
A
Perdikouli
Mirella
M
Boos
Mechthild
M
Mayer
Susanne
S
Scheuring
Sybille
S
Köhrer
Karl
K
Verhoef
Jan
J
Fluit
Ad C
AC
D003165:Complement System Proteins / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005060:Europe; D006801:Humans; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D016870:Neisseriaceae Infections / Q000382:microbiology*; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*; D047090:beta-Lactams / Q000494:pharmacology
D047090:beta-Lactams; D003165:Complement System Proteins; C408134:BRO beta-lactamase; D001618:beta-Lactamases