Cardiac markers of acute coronary syndromes: is there a case for point-of-care testing?
OBJECTIVE
Major challenges for physicians include selection of effective tests in the time-sensitive identification and management of patients with acute coronary syndromes (ACS). We review whether cardiac marker testing performed at the point-of-care (POC) has an impact on clinical management and guidance of intervention for ACS patients.


METHODS
Evidence from recently published studies and meta-analyses supports the efficacy of cardiac markers. Technologies and specifications of all currently available POC tests for monitoring cardiac markers are surveyed. Finally, a series of questions to investigate the utility of cardiac markers, and their measurement by POC tests, for clinical management and guidance of therapy for ACS patients, are addressed.


RESULTS
Cardiac troponins are clearly the best markers for the definitive detection of myocardial infarction. Compelling evidence for the utility of troponins in risk stratification and guidance of intervention for ACS patients has resulted in inclusion of cardiac markers in clinical guidelines. Rapid multi-analyte POC tests, few of which exhibit harmony with central laboratory assays, have facilitated the use of cardiac markers for clinical management and guidance of therapy.


CONCLUSIONS
Given the need to minimize vein-to-brain time, it is expected that point-of-care testing of cardiac markers will take a leading role in management of ACS patients.
Azzazy
Hassan M E
HM
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
Christenson
Robert H
RH
D000208:Acute Disease; D015415:Biomarkers / Q000032:analysis*; D003327:Coronary Disease / Q000175:diagnosis*; D006801:Humans; D019095:Point-of-Care Systems; D013577:Syndrome
D015415:Biomarkers