Linckosides A and B, two new neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata.
Two new steroid glycosides, named linckosides A and B, were isolated from the Okinawan starfish Linckia laevigata, and their stereostructures were elucidated by spectroscopic methods and chemical derivatization. Each of them possesses two monosaccharide units at C-3 and C-29 of a polyhydroxylated steroid aglycon. These steroid glycosides showed not only notable neuritogenic activity against PC12 cells but also significant synergistic effects on the NGF-induced neuronal differentiation of PC12 cells. Linckoside B showed higher activities than those of linckoside A, though the structural difference is only the kind of a sugar.
Qi
Jianhua
J
Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, 464-8601, Nagoya, Japan.
Ojika
Makoto
M
Sakagami
Youji
Y
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D004357:Drug Synergism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013215:Starfish / Q000737:chemistry*
D012503:Saponins; C470915:linckoside A; C470916:linckoside B