Is enteral administration of fluorine-18-fluorodeoxyglucose (F-18 FDG) a palatable alternative to IV injection? Pre-clinical evaluation in normal rodents.
To establish effective methods of enteral 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) administration, the efficiency of FDG absorption in the gastrointestinal tracts following enteral administrations was evaluated using the FDG biodistribution in normal rodents, in combination with various fasting conditions and FDG diluents. The blood FDG curve using hypotonic solution showed a rapid increase, while that in iso- and hypertonic groups showed slow rises. Brain FDG uptake had a close positive correlation with blood AUC (area under curve) and an inverse relationship with the stomach contents.
Higashi
T
T
Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, 1500 E. Medical Center Drive, B1G 505C, Ann Arbor, MI 48109-0028, USA. higashi@kuhp.kyoto-u.ac.jp
Fisher
S J
SJ
Nakada
K
K
Romain
D J
DJ
Wahl
R L
RL
D000818:Animals; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005766:Gastrointestinal Contents / Q000737:chemistry; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D007441:Intubation, Gastrointestinal; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18