Replacement of the intervening amino acid sequence of a Syk-binding diphosphopeptide by a nonpeptide spacer with preservation of high affinity.
Dekker
Frank J
FJ
Department of Medicinal Chemistry, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
de Mol
Nico J
NJ
van Ameijde
Jeroen
J
Fischer
Marcel J E
MJ
Ruijtenbeek
Rob
R
Redegeld
Frank A M
FA
Liskamp
Rob M J
RM
D000595:Amino Acid Sequence; D004792:Enzyme Precursors / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010748:Phosphopeptides / Q000138:chemical synthesis* / Q000378:metabolism / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D020349:Surface Plasmon Resonance; D000072377:Syk Kinase
D004792:Enzyme Precursors; D047908:Intracellular Signaling Peptides and Proteins; D010748:Phosphopeptides; D011994:Recombinant Proteins; D011505:Protein-Tyrosine Kinases; D000072377:Syk Kinase