Seasonal affective disorders: relevance of Icelandic and Icelandic-Canadian evidence to etiologic hypotheses.
OBJECTIVE
This study tests the suggestion of earlier studies concerning the importance of genetic factors in the etiology of winter seasonal affective disorders (SADs) and subsyndromal winter SAD (S-SAD).


METHODS
Two study populations of Winnipeg, Manitoba residents were canvassed: 250 adults of wholly Icelandic descent and 1000 adults of non-Icelandic descent. We distributed the Seasonal Pattern Assessment Questionnaire by mail to these 2 populations, yielding 204 and 449 valid responses, respectively.


RESULTS
Rates of SAD and S-SAD proved markedly lower in the Icelandic population than those in the non-Icelandic population.


CONCLUSIONS
These differences seem unexplained by differences in ambient light or climate, thus indicating that genetic factors contribute to the expression of SADs. Compared with earlier findings from a group of adults of wholly Icelandic descent living in nearby rural Manitoba, the etiologic importance of as-yet-undetermined environmental factors unrelated to latitude or ambient light is also indicated.
Axelsson
Jóhann
J
Department of Physiology, University of Iceland, Vatnsmýrarvegur 16, IS-101 Reykjavík, Iceland. physicel@hi.is
Stefánsson
Jón G
JG
Magnússon
Andrés
A
Sigvaldason
Helgi
H
Karlsson
Mikael M
MM
D000293:Adolescent; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005828:Genetics, Population; D006801:Humans; D007055:Iceland / Q000208:ethnology; D008297:Male; D008350:Manitoba / Q000453:epidemiology; D008875:Middle Aged; D016574:Seasonal Affective Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology