title: [Delayed hypersensitivity to heparins and heparinoids].
abstract: Delayed hypersensitivity to heparins and heparinoïd is a problem for prophylaxis of thrombo embolic diseases. The hirudins did not seem to have any cross-reactivity with the two others groups of anticoagulants. We present two clinical cases of delayed type reactions to heparins and heparinoïd and we reviewed the literature about adverse reactions to low molecular weight heparins and the alternative possibilities.
authors.affiliation: Laboratoire d'immuno-allergologie, CHU-49033 Angers, France.
authors.forename: B
authors.initials: B
authors.lastname: Nicolie
authors.forename: J C
authors.initials: JC
authors.lastname: Bonneau
authors.forename: J
authors.initials: J
authors.lastname: Le Sellin
authors.forename: G
authors.initials: G
authors.lastname: Gay
authors.forename: J M
authors.initials: JM
authors.lastname: Leclere
authors.forename: M
authors.initials: M
authors.lastname: Drouet
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects / Q000276:immunology; D002809:Chondroitin Sulfates / Q000009:adverse effects / Q000276:immunology; D003429:Cross Reactions; D017985:Dalteparin / Q000009:adverse effects / Q000276:immunology; D003871:Dermatan Sulfate / Q000009:adverse effects / Q000276:immunology; D004338:Drug Combinations; D004342:Drug Hypersensitivity / Q000209:etiology*; D017984:Enoxaparin / Q000009:adverse effects / Q000276:immunology; D005260:Female; D006493:Heparin / Q000009:adverse effects* / Q000276:immunology; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects* / Q000276:immunology; D006497:Heparan Sulfate / Q000009:adverse effects / Q000276:immunology; D024764:Hirudin Therapy; D006629:Hirudins / Q000031:analogs & derivatives*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D017762:Nadroparin / Q000009:adverse effects / Q000276:immunology; D011994:Recombinant Proteins / Q000627:therapeutic use; D012882:Skin Tests
chemical_list: D000925:Anticoagulants; D002809:Chondroitin Sulfates; D017985:Dalteparin; D003871:Dermatan Sulfate; D004338:Drug Combinations; D017984:Enoxaparin; D006493:Heparin; D006495:Heparin, Low-Molecular-Weight; D006497:Heparan Sulfate; D006629:Hirudins; D017762:Nadroparin; D011994:Recombinant Proteins; C035838:danaparoid; C060225:desirudin
vernacular_title: Hypersensibilité retardée aux héparines et heparinoïdes.