title: [Clinical implications of rheology in cardiovascular diseases].
abstract: Although a close relationship between haemorrheological disorders and thrombogenesis has been known for a long time, only the recent introduction of newly developed analytical techniques has allowed a precise assessment of the main haemorrheological parameters. The employment of these techniques in routine clinical practice has enabled, for instance, a more accurate investigation of the pathogenetic triggers underlying numerous thrombotic disorders affecting the cardiovascular system. A survey of the most exhaustive prospective studies shows that some haemorrheological parameters (e.g. plasma and blood viscosity) as well as their main determining factors (e.g. haematocrit and fibrinogen) are well defined independent cardiovascular risk factors. Nonetheless, further large scale studies are required to adequately dissect the relative contribution of both haemorrheological alterations and other thrombophilic factors in the pathogenesis of different cardiovascular diseases related to thrombotic disorders.
authors.affiliation: Cattedra di Cardiologia, Università, Brescia. riccardo_raddino@yahoo.it
authors.forename: Riccardo
authors.initials: R
authors.lastname: Raddino
authors.forename: Rubina
authors.initials: R
authors.lastname: Ferrari
authors.forename: Tiziano Maria
authors.initials: TM
authors.lastname: Scarabelli
authors.forename: Cinzia
authors.initials: C
authors.lastname: Portera
authors.forename: Gianluca
authors.initials: G
authors.lastname: Galeazzi
authors.forename: Luisa
authors.initials: L
authors.lastname: Sarasso
authors.forename: Emilio
authors.initials: E
authors.lastname: Ascari
authors.forename: Odoardo
authors.initials: O
authors.lastname: Visioli
mesh_terms: D000328:Adult; D001799:Blood Sedimentation; D001809:Blood Viscosity; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000097:blood / Q000209:etiology; D002648:Child; D003925:Diabetic Angiopathies / Q000097:blood / Q000209:etiology; D005260:Female; D005340:Fibrinogen / Q000032:analysis / Q000502:physiology; D006400:Hematocrit; D018056:Hemorheology; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000209:etiology; D007962:Leukocytes / Q000502:physiology; D008288:Malaria / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000209:etiology; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000209:etiology; D011446:Prospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood / Q000209:etiology
chemical_list: D005340:Fibrinogen
vernacular_title: Implicazioni cliniche della reologia nella patologia cardiovascolare.