Economic impact of cytomegalovirus in solid organ transplantation.
Cytomegalovirus (CMV) infection has a direct effect on morbidity in solid organ transplantation patients, and indirect effects related to the development of opportunistic infections, allograft rejection, and patient mortality. Although intuitively it follows that costs attributable to CMV infections would be increased, direct proof has remained elusive. Accumulating evidence suggests, however, that CMV infection has a significant impact on the costs to transplantation programs, particularly in seronegative recipients of seropositive allografts (D+/R-), and additional costs may be incurred through the effects on CMV potentiating the risks of various opportunistic infections leading to graft rejection.
Paya
C V
CV
Mayo Medical School of Medicine, Rochester, Minnesota, USA. paya@mayo.edu
D000998:Antiviral Agents / Q000191:economics* / Q000627:therapeutic use; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000191:economics* / Q000517:prevention & control*; D017048:Health Care Costs; D015654:Herpesvirus 6, Human / Q000302:isolation & purification; D016199:Herpesvirus 7, Human / Q000302:isolation & purification; D006801:Humans; D007902:Length of Stay / Q000191:economics; D008875:Middle Aged; D016377:Organ Transplantation / Q000191:economics*; D019349:Roseolovirus Infections / Q000191:economics / Q000517:prevention & control; D014481:United States
D000998:Antiviral Agents