[MUSTIC trial].
The atrio-bi-ventricular pacing has been used for hemodynamic improvement since 1994, and the MUSTIC trial is the first controlled study assessing this concept. It collected 67 patients with severe and stable heart failure with optimised medical therapy, with sinus rhythm and without any traditional indication for pacing. After two periods of three months with blinded randomisation and cross-over, the bi-ventricular pacing mode showed its superiority to the inactive mode concerning all study endpoints, for example with an improvement of the functional capacity of 23% assessed by the 6-minutes-walk test. Thus the MUSTIC trial opens up the way for morbidity and mortality studies.
Cazeau
S
S
CHU Rennes.
Leclercq
C
C
Lavergne
T
T
Garrigue
S
S
Bailleul
C
C
Daubert
J C
JC
D000368:Aged; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000628:therapy; D002303:Cardiac Output, Low / Q000628:therapy*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D009026:Mortality; D015337:Multicenter Studies as Topic; D010138:Pacemaker, Artificial; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
L'essai MUSTIC.