Croblongifolin, a new anticancer clerodane from Croton oblongifolius.
A new furoclerodane, croblongifolin, together with one known clerodane, crovatin and one known labdane, nidorellol, were isolated from the stem bark of Croton oblongifolius. Structures were established based on spectroscopic and X-ray analysis. Croblongifolin showed a significant cytotoxicity against various human tumor cell lines including HEP-G2, SW620, CHAGO, KATO3 and BT474.
Roengsumran
Sophon
S
Musikul
Kusalin
K
Petsom
Amorn
A
Vilaivan
Tirayut
T
Sangvanich
Polkit
P
Pornpakakul
Surachai
S
Puthong
Songchan
S
Chaichantipyuth
Chaiyo
C
Jaiboon
Nongnuj
N
Chaichit
Narongsak
N
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D029802:Croton; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045785:Diterpenes, Clerodane; D004317:Doxorubicin / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014961:X-Ray Diffraction
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045785:Diterpenes, Clerodane; D005663:Furans; D010936:Plant Extracts; C458700:croblongifolin; D004317:Doxorubicin