2-Octyl-cyanoacrylate (Dermabond), a new glue for variceal injection therapy: results of a preliminary animal study.
BACKGROUND
Endotherapy of bleeding gastric varices is problematic. The aim of this descriptive study in an animal model was to compare 2-octyl-cyanoacrylate (Dermabond), a Food and Drug Administration-approved agent for superficial wound closure, to N-butyl-2-cyanoacrylate (Histoacryl), an agent available outside of the United States for the endoscopic treatment of bleeding gastric varices.


METHODS
Eight New Zealand white rabbits were randomly assigned to either the study agent Dermabond or the control agent, Histoacryl. Both active agents were equally mixed with ethiodized poppy seed oil (Ethiodol) and injected into the auricular vein. The animals were euthanized at various time intervals after injection. A 2 cm strip of tissue on either side of the injection site along with the adjacent perivascular tissues were resected for histologic evaluation.


RESULTS
The use of 0.5 mL of Dermabond effectively induced vascular occlusion compared with 0.2 mL of Histoacryl. The histologic changes acutely and at 1 week were similar with each mixture.


CONCLUSIONS
Dermabond may be useful in the treatment of gastric variceal bleeding, but further studies are necessary to determine dose response rates in animals and humans.
Nguyen
Adrienne J
AJ
Division of Gastroenterology and Hepatology, Developmental Endoscopy Unit, Department of Pathology, Mayo Medical Center, Rochester, Minnesota, USA.
Baron
Todd H
TH
Burgart
Lawrence J
LJ
Leontovich
Olga
O
Rajan
Elizabeth
E
Gostout
Christopher J
CJ
D000818:Animals; D003487:Cyanoacrylates / Q000008:administration & dosage / Q000627:therapeutic use*; D004423:Ear / Q000098:blood supply; D004659:Enbucrilate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004932:Esophageal and Gastric Varices / Q000628:therapy*; D006471:Gastrointestinal Hemorrhage / Q000628:therapy*; D007275:Injections, Intravenous; D023421:Models, Animal; D011817:Rabbits; D011897:Random Allocation; D014014:Tissue Adhesives / Q000008:administration & dosage / Q000627:therapeutic use*
D003487:Cyanoacrylates; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate; D004659:Enbucrilate