Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias.
When a new (cardiovascular) drug shows signs of QT interval prolongation on the ECG (delay in repolarization time), the regulatory agencies demand screening of its possible proarrhythmic potential before approving it for clinical practice. In this review, identified predisposing factors have been related to specific electrophysiological parameters, allowing quantification of their contribution to Torsade de Pointes arrhythmias. In addition, arrhythmogenic mechanisms involved in the initiation and perpetuation of drug-induced Torsade de Pointes are discussed.
Vos
M A
MA
Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, P.O. Box 5800, 6202 AZ, The Netherlands. m.vos@cardio.azm.nl
van Opstal
J M
JM
Leunissen
J D
JD
Verduyn
S C
SC
D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use; D016757:Death, Sudden, Cardiac; D064420:Drug-Related Side Effects and Adverse Reactions; D004562:Electrocardiography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D012737:Sex Factors; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000503:physiopathology*
D000889:Anti-Arrhythmia Agents