[Influence of triiodothyronine and insulin on liver adenine nucleotide levels in portal triad-clamping rats].
OBJECTIVE
To assess the influence of triiodothyronine(T3) and insulin on liver adenine nucleotide levels in portal triad-clamping rats.


METHODS
A rat model of normothermic portal triad clamping was established to observe the influence of T3 and insulin on the contents of liver adenine nucleotides and survival rates.


RESULTS
The ATP levels and the 72 h-survival rate of T3 group were significantly higher than those of insulin group and saline group(P < 0.05). The blood glucose levels were obviously decreased and all the rats died within 6 hours postoperation in insulin group.


CONCLUSIONS
T3 can improve hepatic energy metabolism after portal triad clamping and increase survival rate, whereas such effects were not found in insulin group.
Liu
P
P
Department of Surgery, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Wu
S
S
Liu
Q
Q
D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D003250:Constriction; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D011169:Portal Vein; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014284:Triiodothyronine / Q000494:pharmacology*
D000227:Adenine Nucleotides; D007328:Insulin; D014284:Triiodothyronine