Effects of dopaminergic drugs and telencephalic ablation on eye movements in the goldfish, Carassius auratus.
The effect of the dopamine agonist apomorphine and the antagonist haloperidol on eye movements was tested in normal and telencephalon ablated goldfish. Reflex eye movements evoked by a rotating striped cylinder were not affected, which suggests that basic sensory and motor functions were not influenced by neither dopaminergic drugs nor the telencephalon. However, profound changes were observed in spontaneous eye movements. Particularly, the effect of apomorphine was similar to changes in eye movements observed in mammals after suppression of dopaminergic functions either by means of drugs or in patients suffering from Parkinson's disease or schizophrenia.
Dietrich
Marcus
M
Institute of Zoology, University of Bonn, Bonn, Germany.
Hofmann
Michael H
MH
Bleckmann
Horst
H
D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology*; D005133:Eye Movements / Q000187:drug effects* / Q000502:physiology*; D006054:Goldfish / Q000502:physiology*; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D013687:Telencephalon / Q000502:physiology*
D015259:Dopamine Agents