An efficient chemical synthesis of nicotinamide riboside (NAR) and analogues.
A simple and efficient synthesis of nicotinamide riboside (NAR) 1 and derivatives 4 and 5 via trimethylsilyl trifluoromethanesulfonate (TMSOTf)-mediated N-glycosilation followed by spontaneous deacetylation by treating with methanol is reported.
Tanimori
Shinji
S
Department of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai, 599-8531, Osaka, Japan. tanimori@biochem.osakafu-u.ac.jp
Ohta
Takeshi
T
Kirihata
Mitsunori
M
D000107:Acetylation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D011726:Pyridinium Compounds
D011726:Pyridinium Compounds; C018613:nicotinamide-beta-riboside; D009536:Niacinamide