title: Cutting balloon angioplasty for treatment of coronary in-stent restenosis: immediate results and 6-month outcomes.
abstract: OBJECTIVE
  To determine the mid-term effects of cutting balloon angioplasty (CBA) on in-stent restenosis.
  
  
  METHODS
  A total of 69 patients with in-stent restenosis were divided into 2 groups randomly: cutting balloon angioplasty and plain old balloon angioplasty. The mechanisms of restenosis and dilation results were determined by quantitative coronary angiography and intravascular ultrasound. Follow-up was performed.
  
  
  RESULTS
  The procedural success rate was 100% without death and acute closure. One patient experienced dissection at the distal end of the stent and needed another stent. The mean follow-up period was 6.7 +/- 2.3 months. The final re-restenosis rate was 15% and 18% at 3 months and 6 months respectively, markedly lower than after plain old balloon angioplasty (38% and 43%). Acute gain by intravascular ultrasound (IVUS) was 1.72 +/- 0.52 mm after cutting balloon angioplasty, higher than 1.15 +/- 0.54 mm after plain old balloon angioplasty. The lumen diameter late loss in the cutting balloon group was 0.26 +/- 0.05 mm and 0.38 +/- 0.06 mm at 3 months and 6 months respectively, significantly lower than for those in conventional balloon group (0.78 +/- 0.19 mm and 0.89 +/- 0.16 mm, respectively, P < 0.001). As shown by IVUS, the main mechanism of cutting balloon angioplasty was marked reduction of plaque area without significant increase of vessel area (less vessel trauma).
  
  
  CONCLUSIONS
  Cutting balloon angioplasty is feasible and effective for the treatment of in-stent restenosis with less vessel trauma.
authors.affiliation: Department of Cardiology, Nanjing First Hospital, Nanjing 210006, China.
authors.forename: Shaoliang
authors.initials: S
authors.lastname: Chen
authors.forename: Baoxiang
authors.initials: B
authors.lastname: Duan
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Liu
authors.forename: Xiang
authors.initials: X
authors.lastname: Wu
authors.forename: Fuxiang
authors.initials: F
authors.lastname: Wei
authors.forename: Xueli
authors.initials: X
authors.lastname: Qian
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.forename: Wuwang
authors.initials: W
authors.lastname: Fang
authors.forename: Zuoying
authors.initials: Z
authors.lastname: Hu
authors.forename: Isreal
authors.initials: I
authors.lastname: Tamari
authors.forename: Huaiqing
authors.initials: H
authors.lastname: Chen
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon / Q000379:methods*; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000628:therapy*; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome