Protein folding: is hierarchical versus nonhierarchical a productive issue?
A coarse-grained simulation accessing relevant folding timescales for beta-lactoglobulin was corroborated experimentally and reveals a dynamic role for nonnative structures dictated by local propensity vis-á-vis the large-scale context. This picture prompts us to shift focus, leaving aside the hierarchical vs. nonhierarchical controversy.
Fernández
Ariel
A
Institute for Biophysical Dynamics, Cummings Life Science Center #439D, The University of Chicago, Chicago, IL 60637, USA. ariel@uchicago.edu
D007700:Kinetics; D007782:Lactoglobulins / Q000737:chemistry; D017510:Protein Folding; D017433:Protein Structure, Secondary
D007782:Lactoglobulins