title: A feline CD2 homologue interacts with human red blood cells.
abstract: A cDNA encoding a feline homologue of CD2 (fCD2) was identified. Several amino acids (aa) important for ligand interaction, molecular folding or signal transduction, found in other mammalian CD2, were found to be highly conserved in the predicted fCD2 aa sequence. fCD2-expressing cells were able to form rosettes with human red blood cells (probably via human CD58), and the rosette formation was inhibited by an anti-fCD2 monoclonal antibody. These results are indicative of the similarity of feline and human CD2 structures. fCD2 was found to be expressed in feline peripheral blood T lymphocytes, monocytes and cultured lymphoid cells.
authors.affiliation: Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shimojima
authors.forename: Yorihiro
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Miyazawa
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kato
authors.forename: Kazuya
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Izumiya
authors.forename: Hiroomi
authors.initials: H
authors.lastname: Akashi
authors.forename: Yukinobu
authors.initials: Y
authors.lastname: Tohya
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D018801:CD2 Antigens / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D002415:Cats / Q000276:immunology*; D017124:Conserved Sequence; D018076:DNA, Complementary / Q000235:genetics; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D009000:Monocytes / Q000276:immunology; D012397:Rosette Formation; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D018801:CD2 Antigens; D018076:DNA, Complementary