Defining the dynamics of self-assembled Fas-receptor activation.
Fas-Fas-ligand, the most well investigated apoptotic signaling system, plays a pivotal role in several human diseases. Its signaling through multiple pathways; multiple, complex regulatory points; and recently described tendency to undergo ligand-independent self-assembly warrant a comprehensive understanding of its physiologically well controlled function. In this review, we attempt to develop such a perspective on the regulation of Fas signaling. The multistep Fas regulation model presented here should be helpful in devising effective interventions for conditions resulting from the dysregulation of Fas.
Mundle
Suneel D
SD
Rush Cancer Institute, Rush-Presbyterian St Luke's Medical Center, 2242 West Harrison Street, Suite 108, Chicago, IL 60612-3515, USA. smundle@rush.edu
Raza
Azra
A
D000818:Animals; D017209:Apoptosis; D016207:Cytokines / Q000378:metabolism; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008954:Models, Biological; D015398:Signal Transduction; D019014:fas Receptor / Q000378:metabolism*
D016207:Cytokines; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor