Metastatic papillary craniopharyngioma: case study and study of tumor angiogenesis.
We report a case of suprasellar papillary craniopharyngioma metastatic to the temporoparietal region 2 years after its initial resection. The literature documents examples of craniopharyngioma recurrences along the surgical tract, as well as remote ipsi- and contralateral metastases via cerebrospinal fluid seeding. Ours is the second report of a craniopharyngioma of papillary type to exhibit metastatic behavior. The tumor spread opposite the side of craniotomy. Although a rare occurrence, it confirms the limited capacity of histologically benign craniopharyngiomas to undergo meningeal seeding, likely the result of surgical manipulation. Immunohistochemical demonstration of increased microvascular density and vascular endothelial growth factor expression, as well as a high vascular endothelial growth receptor (VEGFR2) signal by in situ hybridization, suggests that tumor vascularity facilitated angiogenesis and may have been involved in the establishment and growth of the metastatic deposit.
Elmaci
Lhan
L
Department of Neurosurgery, Marmara University School of Medicine, Istanbul, Turkey.
Kurtkaya-Yapicier
Ozlem
O
Ekinci
Gazanfer
G
Sav
Aydin
A
Pamir
M Necmettin
MN
Vidal
Sergio
S
Kovacs
Kalman
K
Scheithauer
Bernd W
BW
D001706:Biopsy; D001932:Brain Neoplasms / Q000556:secondary*; D003397:Craniopharyngioma / Q000098:blood supply / Q000556:secondary* / Q000601:surgery; D016228:Endothelial Growth Factors / Q000032:analysis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D008222:Lymphokines / Q000032:analysis; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism; D010296:Parietal Lobe; D010911:Pituitary Neoplasms / Q000098:blood supply / Q000473:pathology*; D020794:Receptor Protein-Tyrosine Kinases / Q000032:analysis; D017978:Receptors, Growth Factor / Q000032:analysis; D040262:Receptors, Vascular Endothelial Growth Factor; D013702:Temporal Lobe; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D017978:Receptors, Growth Factor; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D020794:Receptor Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor