YM-181741, a novel benz[a]anthraquinone antibiotic with anti-Helicobacter pylori activity from Streptomyces sp.
A novel benz[a]anthraquinone, YM-181741, was isolated from the culture broth of actinomycete strain Q57219. The strain was identified as Streptomyces sp. by morphological and chemotaxonomic characterization. YM-181741 was purified from the culture supernatant by serial column chromatography. The structure of YM-181741 was determined by spectroscopic analysis including one- and two-dimensional NMR experiments. YM-181741 showed selective anti-Helicobacterpylori activity with a MIC value of 0.2 microg/ml.
Taniguchi
Masatoshi
M
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., Ibaraki, Japan. taniguti@yamanouchi.co.jp
Nagai
Koji
K
Watanabe
Masato
M
Nimura
Nami
N
Suzuki
Ken-ichi
K
Tanaka
Akihiro
A
D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D016480:Helicobacter pylori / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013302:Streptomyces
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; C451493:YM 181741