[Protein kinase CK2 and cancer: further clues are accumulating].
Protein kinase CK2 appears to interact with different signaling pathways and therefore represents the prototype of a multifunctional protein kinase. The enzyme is highly expressed in most cancers and this higher expression has been tentatively correlated with the involvement of CK2 in the promotion of specific phases of the cell cycle. This review summarizes our current knowledge on how CK2 may also contribute to tumorigenesis through its direct interaction with the cell-survival circuitry.
Filhol
Odile
O
Inserm EMI 0104, Département de biologie moléculaire et structurale, CEA, 17, rue des Martyrs, 38054 Grenoble, France.
Cochet
Claude
C
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D047390:Casein Kinase II; D002453:Cell Cycle / Q000502:physiology; D002470:Cell Survival / Q000502:physiology*; D006801:Humans; D009363:Neoplasm Proteins / Q000502:physiology*; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*
D009363:Neoplasm Proteins; D047390:Casein Kinase II; D017346:Protein Serine-Threonine Kinases
Connexions protéine kinase CK2--cancer: les preuves s'accumulent.