[The prognostic value of serum neuron specific enolase detection in small cell lung cancer].
OBJECTIVE
To evaluate the prognostic value of NSE detection in small cell lung cancer.


METHODS
144 unresectable small cell lung cancer patients were eligible in the retrospective study. NSE was analyzed before chemotherapy and 21 days after chemotherapy using ELISA method.


RESULTS
For D1-NSE, 98 (68.1%) were NSE positive and 46(31.9%) were NSE negative; for D21-NSE, 57(39.6%) were NSE positive and 87 (60.4%) were NSE negative. In univariate analysis, both D1-NSE and D21-NSE have prognostic significance. But in multivariate analysis only D21-NSE is an independent prognostic factor.


CONCLUSIONS
D21-NSE in small cell lung cancer is an independent prognostic factor and may be proposed for use in the clinic and research.
Jin
B
B
Department of Medicine, Shanghai Pneumology Hospital, Shanghai 200433, China.
Zhao
L
L
Zhou
C
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002272:Carcinoembryonic Antigen / Q000097:blood; D018288:Carcinoma, Small Cell / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009474:Neurons; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
D002272:Carcinoembryonic Antigen; D010751:Phosphopyruvate Hydratase