Macroprolactinoma associated with Cushing's disease, successfully treated with cabergoline.
Multiple pituitary hormone hypersecretions have already been described, but the co-occurrence of PRL and ACTH excess is very rare. To our knowledge, medical treatment with cabergoline only, avoiding pituitary surgery and radiotherapy in this type of tumor has never been reported before. This case report deals with a 31-yr-old man affected with a macroprolactinoma associated with a florid clinical image of Cushing's disease. Normalization of the prolactin levels and the disappearance of clinical and biochemical features of Cushing's disease were obtained after administration of medical treatment only.
T'Sjoen
G
G
Department of Endocrinology and Metabolism, University Hospital, Gent, Belgium. guy.tsjoen@rug.ac.be
Defeyter
I
I
Van De Saffele
J
J
Rubens
R
R
Vandeweghe
M
M
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000077465:Cabergoline; D003480:Cushing Syndrome / Q000209:etiology*; D003907:Dexamethasone; D004873:Ergolines / Q000627:therapeutic use*; D005938:Glucocorticoids; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000175:diagnosis / Q000188:drug therapy*; D013973:Thyrotropin-Releasing Hormone; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D004873:Ergolines; D005938:Glucocorticoids; D013973:Thyrotropin-Releasing Hormone; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D000077465:Cabergoline; D006854:Hydrocortisone