title: Uterine tumors resembling ovarian sex-cord tumors producing parathyroid hormone-related protein of the uterine cervix.
abstract: A case of uterine tumors resembling ovarian sex-cord tumors (UTROSCT) producing parathyroid hormone-related protein (PTH-rP) of the uterine cervix is reported. A 66-year-old woman underwent total hysterectomy with bilateral salpingo -oophorectomy due to the possibility of a malignant uterine tumor. A fairly well-circumscribed tumor, measuring 8 x 5 x 7 cm, was present in the myometrium of the cervix and extended into the endocervical mucosa. Histologically, the tumor showed predominantly sex-cord-like differentiation and the features of conventional endometrial low-grade stromal sarcoma were observed in part. Immunohistochemically, the tumor cells were negative for CD10. From these findings, we diagnosed the present case as Clement and Scully's group II UTROSCT arising from the uterine cervix. To our knowledge, this is the first report of the cervical occurrence of UTROSCT. Furthermore, in this tumor, production of PTH-rP was demonstrated by normalization of serum PTH-rP after the tumorectomy and immunoreactivity for PTH-rP in the tumor cells.
authors.affiliation: First Department of Pathology, Juntendo University, School of Medicine, Tokyo, Japan.
authors.forename: Chikako
authors.initials: C
authors.lastname: Suzuki
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Masaharu
authors.initials: M
authors.lastname: Fukunaga
authors.forename: Tomoko
authors.initials: T
authors.lastname: Itoga
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Furugen
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kurosaki
authors.forename: Koichi
authors.initials: K
authors.lastname: Suda
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kinoshita
mesh_terms: D000071443:12E7 Antigen; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D002584:Cervix Uteri / Q000737:chemistry; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D044162:Parathyroid Hormone-Related Protein; D014176:Protein Biosynthesis; D018312:Sex Cord-Gonadal Stromal Tumors / Q000378:metabolism / Q000473:pathology*; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D014746:Vimentin; D007633:Keratins