Analysis of Fgf15 expression pattern in the mouse neural tube.
The dynamic process of neural tube regionalization in vertebrates is regulated by the expression of developmental genes which appear in characteristic patterns at neuroepithelial transversal domains, which are called secondary organizers. The molecular code present in these neuroepithelial organizers controls the generation of morphogenetic signals that induce and maintain regional characteristics in the surrounding neuroepithelium. The product of the Fgf8 gene is a secreted protein that has been demonstrated to be the key molecule for the isthmic organizer and is also expressed in two other organizer regions: the zona limitans and the anterior neural ridge. Here we analyze the expression of Fgf15 at different stages of mouse development in relation to Fgf8 and Otx2 expression patterns.
Gimeno
L
L
Institut of Neurosciences, CSIC-UMH (Miguel Hernandez University), Alicante, Spain.
Hashemi
R
R
Brûlet
P
P
Martínez
S
S
D000818:Animals; D004622:Embryo, Mammalian / Q000378:metabolism; D005314:Embryonic and Fetal Development; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D018398:Homeodomain Proteins; D051379:Mice / Q000196:embryology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009420:Nervous System / Q000196:embryology*; D051857:Otx Transcription Factors; D015534:Trans-Activators / Q000378:metabolism
C496457:Fgf8 protein, mouse; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D051857:Otx Transcription Factors; C497660:Otx2 protein, mouse; D015534:Trans-Activators; C108526:fibroblast growth factor 15, mouse; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors