title: [Tonsillar and erythrocyte levels of superoxide dismutase in children with and without recurrent tonsillitis].
abstract: OBJECTIVE
  Oxidative stress secondary to infant tonsillar infection produces the expression of local and systemic antioxidants. Its determination seems to be useful as a marker of tonsillar suffering before tonsillectomy but is currently unknown. The aim of this study was to determine the evolution of this parameter in tonsillectomized children during a long-term follow-up.
  
  
  METHODS
  One hundred thirty-six children underwent tonsillectomy, 46 for tonsillar hypertrophy without infection and 90 for recurrent tonsillitis. Superoxide dismutase (SOD) concentrations were measured before tonsillectomy and at 6, 12, 24 and 36 months post-tonsillectomy.
  
  
  RESULTS
  Infection provoked significantly higher SOD concentrations than tonsillar hypertrophy in tonsillar tissue (223.06 30.46 vs 156.39 54.05 U/l, p < 0.001) and in blood (1124.91 141.73 vs 1007.19 97.03 U/gr Hb, p < 0.001). There was a strong correlation between tonsillar and erythrocyte concentrations. During the 3-year follow-up, SOD concentrations in blood progressively decreased until stabilizing in all patients. Stabilization was reached at 6 months post-tonsillectomy in the group with tonsillar hypertrophy and at 2 years in the group with infection. Children with recurrent tonsillitis consistently showed higher SOD concentrations in blood throughout the follow-up.
  
  
  CONCLUSIONS
  Oxidative damage in tonsillar tissue results from the incidence and severity of focal infections. Tonsillectomy reduces SOD levels but, as a consequence of oxidative stress, these do not return to normal.
authors.affiliation: Servicio de ORL, Hospital Clínico Universitario, Valencia, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: García Callejo
authors.forename: M H
authors.initials: MH
authors.lastname: Orts Alborch
authors.forename: A
authors.initials: A
authors.lastname: Morant Ventura
authors.forename: I
authors.initials: I
authors.lastname: Costa Alcácer
authors.forename: M M
authors.initials: MM
authors.lastname: Velert Vila
authors.forename: L
authors.initials: L
authors.lastname: Blay Galaud
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000201:enzymology*; D005500:Follow-Up Studies; D006801:Humans; D018384:Oxidative Stress; D014066:Palatine Tonsil / Q000201:enzymology*; D012008:Recurrence; D013053:Spectrophotometry; D013482:Superoxide Dismutase / Q000032:analysis* / Q000097:blood; D013997:Time Factors; D014068:Tonsillectomy; D014069:Tonsillitis / Q000201:enzymology* / Q000601:surgery
chemical_list: D013482:Superoxide Dismutase
vernacular_title: Niveles de superóxido dismutasa amigdalar y eritrocitaria en niños con y sin amigdalitis de repetición.