Linkage disequilibrium and founder effect analysis of the NF1 gene in French Canadians from the Quebec population.
We genotyped 19 neurofibromatosis type 1 (NF1) families from French Canadians of the Quebec population with four intragenic microsatellites (IVS26-2.3, IVS27AC28.4, IVS27AC33.1, and IVS38GT53.0). Linkage analysis of the four microsatellite markers among the 19 NF1 families indicates that the four microsatellites are strongly linked with NF1 disease (LOD = 2.76-3.64). The four markers are associated (P = 0-0.077) except marker pair IVS26-2.3/IVS27AC33.1 (P = 0.18 or 0.17). However, perhaps due to the high mutation rate of the NF1 gene, no founder effect for NF1 was detected in the Quebec French Canadians.
Fang
Li Juan
LJ
Département de microbiologie et d'infectiologie, faculté de médecine, Université de Sherbrooke, Sherbrooke, PQ J1H 5N4, Canada.
Li
Wentian
W
Chalhoub
Nader
N
Feingold
Josué
J
Ortenberg
June
J
Thirion
Jean-Paul
JP
D018703:Founder Effect; D005787:Gene Frequency; D016514:Genes, Neurofibromatosis 1; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D011792:Quebec
D005819:Genetic Markers