title: Surrogate markers of disease in mastocytosis.
abstract: Measurement of surrogate mast cell-related products in blood or urine is often performed to assess disease extent in evaluating patients with mastocytosis. Serum tryptase and 24-hour urine histamine metabolites are the most commonly used surrogate markers of mastocytosis. In addition, several novel markers including soluble CD117 and soluble CD25 have been identified in recent studies. The utility and the pitfalls of each of these measurements are discussed.
authors.affiliation: Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1881, USA. cakin@niaid.nih.gov
authors.forename: Cem
authors.initials: C
authors.lastname: Akin
authors.forename: Dean D
authors.initials: DD
authors.lastname: Metcalfe
mesh_terms: D016718:Arachidonic Acid / Q000378:metabolism; D015415:Biomarkers; D006632:Histamine / Q000378:metabolism* / Q000652:urine; D006801:Humans; D008415:Mastocytosis / Q000175:diagnosis*; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012697:Serine Endopeptidases / Q000097:blood*; D053802:Tryptases
chemical_list: D015415:Biomarkers; D015375:Receptors, Interleukin-2; D016718:Arachidonic Acid; D006632:Histamine; D019009:Proto-Oncogene Proteins c-kit; D012697:Serine Endopeptidases; D053802:Tryptases