Chromatin remodeling enzymes: taming the machines. Third in review series on chromatin dynamics.
Members of the ATP-dependent family of chromatin remodeling enzymes play key roles in the regulation of transcription, development, DNA repair and cell cycle. Each of these enzymes are multi-subunit assemblies that hydrolyze thousands of molecules of ATP in order to change nucleosome positions, disrupt DNA-histone interactions and perhaps destabilize chromatin folding. Here I review recent studies that suggest these potent machines can be 'tamed' by one of several mechanisms: targeting their activity to localized regions, blocking their chromatin binding activity or inhibiting their remodeling activity.
Peterson
Craig L
CL
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. craig.peterson@umassmed.edu
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002843:Chromatin / Q000201:enzymology*; D004247:DNA / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics; D005786:Gene Expression Regulation; D006657:Histones / Q000378:metabolism*; D006801:Humans; D063150:Polycomb Repressive Complex 1
D002843:Chromatin; D029721:Drosophila Proteins; D006657:Histones; C066770:Pc protein, Drosophila; D000255:Adenosine Triphosphate; D004247:DNA; D063150:Polycomb Repressive Complex 1