title: Application of high-throughput, molecular-targeted screening to anticancer drug discovery.
abstract: Increasing insight into the genetics and molecular biology of cancer has resulted in the identification of an increasing number of potential molecular targets for anti-cancer drug discovery and development. These targets can be approached through exploitation of emerging structural biology, "rational" drug design, screening of chemical libraries, or a combination of these methods. In this article we discuss the application of high-throughput screening to anti-cancer drug discovery, with special reference to approaches used at the U.S. National Cancer Institute.
authors.affiliation: Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick, Maryland 21702-1201, USA. shoemaker@dtpax2.ncifcrf.gov
authors.forename: Robert H
authors.initials: RH
authors.lastname: Shoemaker
authors.forename: Dominic A
authors.initials: DA
authors.lastname: Scudiero
authors.forename: Giovanni
authors.initials: G
authors.lastname: Melillo
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Currens
authors.forename: Anne P
authors.initials: AP
authors.lastname: Monks
authors.forename: Alfred A
authors.initials: AA
authors.lastname: Rabow
authors.forename: David G
authors.initials: DG
authors.lastname: Covell
authors.forename: Edward A
authors.initials: EA
authors.lastname: Sausville
mesh_terms: D000465:Algorithms; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents