Immunostimulatory activity of cationic-lipid-nucleic-acid complexes against cancer.
Recent studies have highlighted the immunostimulatory nature of nucleic acids and the enhancement of such immunostimulation when nucleic acids are complexed to cationic liposomes to form cationic-lipid-nucleic-acid-complexes or lipoplexes. While such immunostimulation may have deleterious consequences for nucleic acid delivery, especially in the field of gene therapy, it may be harnessed for efficacious usage against the various forms of cancer.
Dass
C R
CR
Johnson & Johnson Research, 1 Central Avenue, Australian Technology Park, Eveleigh 1430, Australia. cdass@medau.jnj.com
D002412:Cations / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use; D018899:CpG Islands / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D006801:Humans; D016882:ISCOMs / Q000008:administration & dosage / Q000276:immunology* / Q000627:therapeutic use; D008055:Lipids / Q000008:administration & dosage / Q000276:immunology* / Q000627:therapeutic use; D008081:Liposomes; D009841:Oligonucleotides / Q000008:administration & dosage / Q000276:immunology* / Q000627:therapeutic use
D002412:Cations; D016882:ISCOMs; D008055:Lipids; D008081:Liposomes; D009841:Oligonucleotides