[Tissue microarrays, or the advent of chips in pathology].
Tissue microarray technology is a new method used to analyze several hundred tumor samples on a single slide allowing high throughput analysis of genes and proteins on a large cohort. The method consists to core tissues from paraffin-embedded tissue donor blocks and placing them into a single paraffin block. Despite the low amount of tissue analyzed by tissue microarray, different studies have demonstrated a high concordance of protein expression between this technique and the conventional tissue sections.
Terris
Benoît
B
Services d'Anatomie et de Cytologie Pathologiques, AP-HP, Hôpital Cochin, 27, rue du Faubourg- Saint-Jacques, 75614 Paris Cedex, France. benoitterris@hotmail.com
Bralet
Marie-Pierre
MP
D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D009363:Neoplasm Proteins / Q000032:analysis; D009369:Neoplasms / Q000737:chemistry* / Q000235:genetics* / Q000473:pathology; D010232:Paraffin; D010336:Pathology / Q000379:methods*; D016610:Tissue Embedding
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D010232:Paraffin
Tissue microarrays. Ou l'arrivée des puces en anatomie pathologique.