NAADP: an atypical Ca2+-release messenger?
Recently, nicotinic acid adenine dinucleotide phosphate (NAADP) has been shown, using different techniques, to mobilize intracellular Ca2+ stores in invertebrate, lower vertebrate, plant and mammalian cells. This endogenous molecule might play an atypical role in Ca2+ signalling by coordinating the responses of other Ca2+-releasing messengers. Furthermore, radioligand binding experiments have provided an insight into how desensitization of the NAADP receptor might occur.
Genazzani
Armando A
AA
Dept of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD, Cambridge, UK. aag25@cam.ac.uk
Billington
Richard A
RA
D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D009249:NADP / Q000031:analogs & derivatives* / Q000378:metabolism / Q000502:physiology*; D019837:Ryanodine Receptor Calcium Release Channel / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology*
D019837:Ryanodine Receptor Calcium Release Channel; D009249:NADP; C024376:NAADP; D002118:Calcium