Evidence for more than one pathway in the formation of purine deoxyribonucleotides.
The biosynthesis of purine deoxyribonucleotides was studied in the context of general purine nucleotide metabolism in the chick with the aid of radioactive nucleic acid precursors. Our results showed that in chick liver and intestine, the nucleoside phosphate reductase system so firmly established in E. coli [1] and L. leichmanni [2] is not exclusively responsible for the biosynthesis of purine deoxyribonucleotides.
Foung
A
A
Department of Biochemistry, University of California, 92502, Riverside, California, USA
Norman
A W.
AW