Function of insulin-like growth factor (IGF-I) and its binding protein (IGFBP-1) in pathological proliferation of endometrium.
The purpose of this project was the investigation of insulin, IGF-I and IGFBP-1 concentrations in the serum of patients with pathological changes in endometrium. IGF-I and its binding protein (IGFBP-1) stimulate cell growth and differentiation of the normal and neoplastic endometrium. The mean values of IGF-I concentrations in the group of patients with atypical hyperplasia and endometrial carcinoma were significantly higher than in the control group with normal endometrium. Significantly higher IGFBP-1 concentrations were found in the serum of patients with the atypical hyperplasia of endometrium and endometrial carcinoma. The correlation between insulin concentration and changes in endometrium in the examined groups was not found.
Waksmański
B
B
Medical University of Silesia, Katowice, Poland. bogwiol@mp.pl
Dudkiewicz
J
J
Dabrowski
S
S
D000328:Adult; D016022:Case-Control Studies; D004714:Endometrial Hyperplasia / Q000097:blood* / Q000503:physiopathology; D016889:Endometrial Neoplasms / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008875:Middle Aged; D014592:Uterine Hemorrhage / Q000097:blood
D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I