[Preventive and therapeutic effects of calcium lactate on osteoporosis in aged ovariectomized rats].
Twelve-month-old rats were ovariectomized (OVX), remained untreated for one month. Calcium lactate was given daily by gavage at the dose of 125, 250 and 750 mg/kg(Ca125, Ca250, Ca750) for 3 months. The results showed that compared with OVX rats, Ca250 could markedly increase the bone mineral density (BMD) at right femur. Both Ca250 and Ca750 could markedly enhance the ash weight, ratio of ash weight to dry weight of left femur and ratio of 24-hour urinary Ca/Cr. Ca125 could markedly decrease serum ALP concentration. Both Ca125 and Ca250 could decrease the ratio of 24-hour urinary Hop/Cr. All doses of calcium lactate groups could elevate serum Ca, and were no influence on the volume, wet and dry weight of the left femur and serum OC levels. In conclusion, the administration of calcium lactate to aged OVX rats prevents bone resorption, and its mechanism may be relating to the supplement of calcium properly.
Gong
H
H
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Li
W
W
Lu
C
C
Liu
J
J
D000818:Animals; D015519:Bone Density; D017610:Calcium Compounds / Q000627:therapeutic use*; D005260:Female; D005269:Femur / Q000378:metabolism; D006801:Humans; D007773:Lactates / Q000627:therapeutic use*; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy* / Q000517:prevention & control; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D017610:Calcium Compounds; D007773:Lactates; C110051:calcium lactate