title: New cytotoxic cucurbitacins from the pericarps of Trichosanthes tricuspidata fruits.
abstract: An extract of the fruits of Trichosanthes tricuspidata collected in North Vietnam was found cytotoxic in KB cells. A bioassay-guided fractionation led to the isolation of a series of cucurbitacins of which two are new: tricuspidatin and 2-O-glucocucurbitacin J. Their isolation and structure determination are described.
authors.affiliation: Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.
authors.forename: Le Phuong
authors.initials: le P
authors.lastname: Mai
authors.forename: Daniel
authors.initials: D
authors.lastname: Guénard
authors.forename: Marc
authors.initials: M
authors.lastname: Franck
authors.forename: Tri Mai
authors.initials: TM
authors.lastname: Van
authors.forename: Christiane
authors.initials: C
authors.lastname: Gaspard
authors.forename: Thierry
authors.initials: T
authors.lastname: Sévenet
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002853:Chromatography, Liquid; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D029778:Trichosanthes / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014744:Vietnam
chemical_list: C456088:2-O-glucocucurbitacin J; D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D014315:Triterpenes; C456087:tricuspidatin