title: [Use of the multi-component VP-4 vaccine to prevent acute respiratory diseases at preschool children's establishments].
abstract: The multicomponent VP-4 vaccine from Klebsiella pneumonia, Staphyloccocus aureus, Proteus vulgaris, Escherichia coli antigens was used to prevent acute respiratory diseases (ARD) at preschoolchildren's establishments. Prevention was effected during an influenza epidemic with a drastic rise in the incidence of ARD. The VP-4 use involved 3 nasal and 6-9 oral administrations of the drug at an interval of 3-4 days. The duration of the course was 26 +/- 4 days. The preventive action of VP-4 on the incidence of ARD was followed up for 14 months after vaccination. One group comprised 89 vaccinated children, a matched group included 69 children whose age was 2 to 6 years. Immunoprophylaxis was found to promote a reduction in the number of children who had 4 ARD episodes or more during the whole follow-up. Administration of VP-4 prevented the development of repeated episodes ARD in a group of children aged 2-3 years and in frequently ill children who had 3 infections or more in the previous year. The slight reactogenicity of the drug and its long-term preventive effect allow this method of immunoprophylaxis to be recommended for frequently ill children, for those at high risk, and for those in the junior age group (under 4 years) before going to preschoolchildren's establishments.
authors.forename: N B
authors.initials: NB
authors.lastname: Egorova
authors.forename: B F
authors.initials: BF
authors.lastname: Semenov
authors.forename: E A
authors.initials: EA
authors.lastname: Kurbatova
authors.forename: V N
authors.initials: VN
authors.lastname: Efremova
authors.forename: I M
authors.initials: IM
authors.lastname: Gruber
authors.forename: L A
authors.initials: LA
authors.lastname: Kuz'mina
authors.forename: I B
authors.initials: IB
authors.lastname: Semenova
mesh_terms: D001428:Bacterial Vaccines / Q000737:chemistry / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D015994:Incidence; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000517:prevention & control*; D012572:School Health Services / Q000458:organization & administration*; D013997:Time Factors; D017778:Vaccines, Combined
chemical_list: D001428:Bacterial Vaccines; C088865:VP-4 vaccine; D017778:Vaccines, Combined
vernacular_title: Isopol'zovanie polikomponentnoĭ vaktsiny VP-4 dlia profilaktiki ostrykh respiratornykh zabolevaniĭ v detskikh doshkol'nykh uchrezhdeniiakh.