title: The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract: friend or foe?
abstract: OBJECTIVE
  To evaluate the role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract.
  
  
  METHODS
  Prospective study; institutional review board-approved clinical trial.
  
  
  METHODS
  Tertiary care pediatric medical center.
  
  
  METHODS
  Fifteen patients; choanal atresia in 5 patients, airway stenosis in 8 patients, hypopharyngeal stenosis in 1 patient, and esophageal stenosis in 1 patient.
  
  
  RESULTS
  The efficacy and safety of mitomycin in the prevention of scar formation.
  
  
  METHODS
  All patients underwent surgical repair of the stenotic area, followed by topical application of mitomycin (1 mL of 0.4 mg/mL) for 4 minutes.
  
  
  RESULTS
  Ten patients (67%) showed major improvement, 4 patients (27%) showed minor improvement, and 1 patient (7%) showed no improvement.
  
  
  CONCLUSIONS
  Topical application of mitomycin can play an effective role in the prevention and treatment of scar formation in the aerodigestive tract.
authors.affiliation: Department of Otolaryngology and Communication Disorders, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA. reza.rahbar@tch.harvard.edu
authors.forename: Reza
authors.initials: R
authors.lastname: Rahbar
authors.forename: Dwight T
authors.initials: DT
authors.lastname: Jones
authors.forename: Roger C
authors.initials: RC
authors.lastname: Nuss
authors.forename: David W
authors.initials: DW
authors.lastname: Roberson
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Kenna
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: McGill
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Healy
mesh_terms: D000287:Administration, Topical; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002754:Choanal Atresia / Q000188:drug therapy / Q000601:surgery; D002921:Cicatrix / Q000517:prevention & control*; D003251:Constriction, Pathologic; D004940:Esophageal Stenosis / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007829:Laryngostenosis / Q000188:drug therapy / Q000601:surgery; D008297:Male; D016685:Mitomycin / Q000494:pharmacology / Q000627:therapeutic use*; D010608:Pharyngeal Diseases / Q000188:drug therapy / Q000601:surgery; D011446:Prospective Studies; D012140:Respiratory Tract Diseases / Q000188:drug therapy* / Q000601:surgery; D015607:Stents; D014135:Tracheal Stenosis / Q000188:drug therapy / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D016685:Mitomycin