Drug delivery systems based on sugar-macromolecule conjugates.
The specificity of carbohydrate-protein interactions can greatly outstrip that of many other ligand-binding systems; such is the enormous density of information that sugars can convey. In addition, macromolecules allow for the fine-tuning of active drug delivery through their great ability to undergo site-specific modification and their inherent physicochemical properties. Once combined, these two factors suggest that sugar-macromolecule conjugates, targeted using endogenous carbohydrate binding proteins, are a promising route to the 'magic bullet'.
Davis
Benjamin G
BG
Dyson Perrins Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QY, UK. Ben.Davis@chem.ox.ac.uk
Robinson
Mark A
MA
D000818:Animals; D002241:Carbohydrates / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D046911:Macromolecular Substances; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry
D002241:Carbohydrates; D004337:Drug Carriers; D046911:Macromolecular Substances; D010455:Peptides; D011134:Polysaccharides; D011506:Proteins