title: Differential response of wheezes and ruttles to anticholinergics.
abstract: Computerised breath sounds analysis was used to assess the response of infants with wheeze and ruttles to the drug ipratropium bromide. A mean decrease in breath sounds intensity occurred in infants with ruttles after five minutes (20.5 dB), but not until 20 minutes in those with wheeze (8.1 dB). This differential response may be related to different underlying pathophysiology.
authors.affiliation: Paediatric Respiratory Unit, Sheffield Children's Hospital, Western Bank, Sheffield S10 2TH, UK. helphick@liv.ac.uk
authors.forename: H E
authors.initials: HE
authors.lastname: Elphick
authors.forename: S
authors.initials: S
authors.lastname: Ritson
authors.forename: M L
authors.initials: ML
authors.lastname: Everard
mesh_terms: D001993:Bronchodilator Agents / Q000627:therapeutic use*; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D009241:Ipratropium / Q000627:therapeutic use*; D008297:Male; D012135:Respiratory Sounds / Q000187:drug effects*
chemical_list: D001993:Bronchodilator Agents; D018680:Cholinergic Antagonists; D009241:Ipratropium