Alzheimer's disease research enters a "new cycle": how significant?
Recent evidence suggests a link between the aberrant re-expression of cell cycle proteins in adult neurons of the Alzheimer's disease brain and the process of apoptotic degeneration. Here we will discuss this unexpected phenomenon as related to the mechanisms of beta-amyloid toxicity, and its significance for therapeutic possibilities.
Copani
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Department of Chemical Sciences, Section of Biochemistry and Molecular Biology, University of Catania, Italy. acopani@katamail.com
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Nicoletti
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Giuffrida
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D000544:Alzheimer Disease / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D006801:Humans; D008934:Mitogens / Q000378:metabolism; D009448:Neurochemistry / Q000639:trends*; D009474:Neurons / Q000378:metabolism*; D012106:Research
D016229:Amyloid beta-Peptides; D018797:Cell Cycle Proteins; D008934:Mitogens