title: Melanoma Cell Adhesion Molecule (MCAM) expression in the myogenic lineage during early chick embryonic development.
abstract: We describe the expression pattern of cMCAM, a cell adhesion molecule of the immunoglobulin superfamily, in early chick embryonic development by in situ hybridisation. An initial ectodermal domain of expression is subsequently expanded, and cMCAM is expressed in the neural crest cells, otic vesicle, heart primordium, notochord and endoderm. In addition, cMCAM expression localises in the myotome once the somite cells have been specified. An in vitro murine cellular system allowed us to confirm that MCAM expression coincides with the onset of myogenic cell determination.
authors.affiliation: CNRS UMR7622, Université Pierre et Marie Curie, Paris, France. cpujades@snv.jussieu.fr
authors.forename: Cristina
authors.initials: C
authors.lastname: Pujades
authors.forename: Borhane
authors.initials: B
authors.lastname: Guez-Guez
authors.forename: Dominique
authors.initials: D
authors.lastname: Dunon
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D015703:Antigens, CD; D000954:Antigens, Surface / Q000096:biosynthesis* / Q000378:metabolism*; D015152:Blotting, Northern; D051929:CD146 Antigen; D002448:Cell Adhesion; D002460:Cell Line; D019070:Cell Lineage; D002478:Cells, Cultured; D002642:Chick Embryo; D018076:DNA, Complementary / Q000378:metabolism; D004475:Ectoderm / Q000378:metabolism; D017403:In Situ Hybridization; D008562:Membrane Glycoproteins; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D008856:Microscopy, Fluorescence; D019006:Neural Cell Adhesion Molecules; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D015703:Antigens, CD; D000954:Antigens, Surface; D051929:CD146 Antigen; D018076:DNA, Complementary; C497903:Mcam protein, mouse; D008562:Membrane Glycoproteins; D019006:Neural Cell Adhesion Molecules; D020033:Protein Isoforms; D012333:RNA, Messenger