title: [Observation on curative effect of acute ischemic cerebrovascular disease treated with different dosage of ligustrazine].
abstract: OBJECTIVE
  To compare clinical curative effect of acute ischemic cerebrovascular diseases (ICVD) treated with different dosage of ligustrazine and to observe the effect of ligustrazine on hemorrheology.
  
  
  METHODS
  Sixty-nine patients with ICVD were randomized into three groups, the Group A, B and C treated with 120 mg, 240 mg and 480 mg of ligustrazine respectively, the clinical curative effect, the changes in nerve function deficit score and hemorrheologic parameters before and after treatment were observed.
  
  
  RESULTS
  The clinical curative effect and improvement of hemorrheologic parameters in Group C were better than those in Group A and B significantly (P < 0.05, P < 0.01 respectively). Ligustrazine also showed obvious effect in lowering blood level of fibrinogen in Group C.
  
  
  CONCLUSIONS
  Treatment of acute ICVD with large dose of ligustrazine is good in improving clinical effect and hemorrheology, and without side effect basically.
authors.affiliation: Institute of Neurology, Anhui College of TCM, Hefei 230031.
authors.forename: Y
authors.initials: Y
authors.lastname: Cai
authors.forename: M
authors.initials: M
authors.lastname: Ren
authors.forename: R
authors.initials: R
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D002544:Cerebral Infarction / Q000097:blood / Q000188:drug therapy*; D018056:Hemorheology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011719:Pyrazines / Q000008:administration & dosage*; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D011719:Pyrazines; D014665:Vasodilator Agents; C017953:tetramethylpyrazine