title: Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites.
abstract: A unique pentaketide dimer structure of a novel fungal metabolite with antiangiogenic activity, designated as epoxyquinol A (1), was determined on the basis of NMR spectral data as well as the X-ray crystallographic analysis. 1 inhibits the endothelial migration induced by vascular endothelial growth factor (ED100 = 3 mug/mL).
authors.affiliation: Antibiotics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kakeya
authors.forename: Rie
authors.initials: R
authors.lastname: Onose
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koshino
authors.forename: Arika
authors.initials: A
authors.lastname: Yoshida
authors.forename: Kimiko
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Shun-Ichiro
authors.initials: S
authors.lastname: Kageyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry*; D006873:Hydroquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D012988:Soil Microbiology
chemical_list: D020533:Angiogenesis Inhibitors; D004852:Epoxy Compounds; D006873:Hydroquinones; C455959:epoxyquinol A