[Involvement of polynuclear eosinophils and of type TH2 immune responses in allograft rejections].
In the present work, we showed that mouse alloreactive Th2 type lymphocytes are able to acutely or chronically reject the MHC class II disparate skin allografts. Acute skin allograft rejection is characterized by IL5 production and eosinophils infiltration. IL5 neutralization in the absence of CD4 T cell cytotoxicity prevented the eosinophil infiltration and the acute rejection in the large majority of recipients. Chronic rejection was characterized by graft fibrosis and vasculopathy. Whereas IL4 and IL5 neutralization prevented eosinophil infiltration and graft fibrosis, the sole IL4 neutralization completely prevented vasculopathy, which was eosinophil and IL5 independent. Together, these observations illustrate the mechanisms used by Th2 alloreactive cells in the allograft rejection process.
Le Moine
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Service de Néphrologie, Hopital Erasme, U.L.B.
D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D004804:Eosinophils / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology*
Implication des polynucléaires éosinophiles et des réponses immunes de type TH2 dans les rejets d'allogreffes.