A comparative evaluation of the effects of oral lorazepam, alprazolam and diazepam on venous admixture.
OBJECTIVE
To compare the effects of oral diazepam, lorazepam and alprazolam premedication on venous admixture.


METHODS
One hundred fifty patients divided in three groups were included in the study. The venous admixture was determined using the ISO-shunt nomogram. The values obtained 90 minutes after administration of the drugs were compared with the values before the drug administration. The Student's t-test was applied to find out the significance.


RESULTS
These were highly significant change in increase in venous admixture (Qs/Qt) in group I patients 90 minutes after premedication as compared to premedication values. There was statistically insignificant difference in venous admixture (Qs/Qt) in group II and group III patients 90 minutes after premedication as compared to premedication values.


CONCLUSIONS
From the present study it can be concluded that 2 mg of oral lorozepam given 90 minutes before surgery to healthy patients have significant effects on venous admixture. However, the effects of alprazolam and diazepam had no significant effect on venous admixture.
Naqib
A
A
Department of Anaesthesiology, SKIMS, Soura, Srinagar-Kashmir.
Mir
B
B
Beigh
A
A
D000284:Administration, Oral; D000328:Adult; D000525:Alprazolam / Q000008:administration & dosage / Q000097:blood*; D001784:Blood Gas Analysis; D003975:Diazepam / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000097:blood*; D008140:Lorazepam / Q000008:administration & dosage / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011229:Preanesthetic Medication
D006993:Hypnotics and Sedatives; D008140:Lorazepam; D003975:Diazepam; D000525:Alprazolam