title: Expression of stress-induced MHC class I related chain molecules on human melanoma.
abstract: Cellular immune responses to melanoma are tightly regulated and include specific T cell responses to self antigens such as Mart-1 and gp100. Thus, additional signals apart from those mediated by the T cell receptor are needed to ensure T cell activation. Recently, the stress inducible major histocompatibility complex molecules, MHC class I related chain, were identified as an activator of both natural killer and T cells via interaction with their receptor NKG2D. Herein, we report the expression of MIC in 31 of 40 primary cutaneous melanomas and in 13 of 20 metastatic lesions. Moreover, lymphocytes infiltrating the tumor were found to express NKG2D. Detailed analysis identified both CD3+ T cells as well as CD56+ natural killer cells contributing to this NKG2D+ tumor infiltrating lymphocyte population present.
authors.affiliation: Department of Dermatology, Julius-Maximilians-University, Würzburg, Germany.
authors.forename: Claudia S
authors.initials: CS
authors.lastname: Vetter
authors.forename: Veronika
authors.initials: V
authors.lastname: Groh
authors.forename: Per
authors.initials: P
authors.lastname: thor Straten
authors.forename: Thomas
authors.initials: T
authors.lastname: Spies
authors.forename: Eva-B
authors.initials: EB
authors.lastname: Bröcker
authors.forename: Jürgen C
authors.initials: JC
authors.lastname: Becker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002999:Clone Cells; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D007694:Killer Cells, Natural / Q000737:chemistry / Q000378:metabolism; D008297:Male; D008545:Melanoma / Q000276:immunology* / Q000378:metabolism / Q000556:secondary; D008875:Middle Aged; D055655:NK Cell Lectin-Like Receptor Subfamily K; D011971:Receptors, Immunologic / Q000032:analysis / Q000096:biosynthesis; D055607:Receptors, Natural Killer Cell; D012878:Skin Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000556:secondary; D013312:Stress, Physiological / Q000276:immunology; D013601:T-Lymphocytes / Q000737:chemistry / Q000166:cytology / Q000378:metabolism
chemical_list: D015395:Histocompatibility Antigens Class I; C527085:KLRK1 protein, human; D055655:NK Cell Lectin-Like Receptor Subfamily K; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell