title: Cough, airway inflammation, and mild asthma exacerbation.
abstract: BACKGROUND
  Prospective data on the temporal relation between cough, asthma symptoms, and airway inflammation in childhood asthma is unavailable.
  
  
  OBJECTIVE
  Using several clinical (diary, quality of life), lung function (FEV(1), FEV(1) variability, airway hyperresponsiveness), cough (diary, cough receptor sensitivity (CRS)), and inflammatory markers (sputum interleukin 8, eosinophilic cationic protein (ECP), myeloperoxidase; and serum ECP) of asthma severity, we prospectively described the course of these markers in children with asthma during a non-acute, acute, and resolution phase. A total of 21 children with asthma underwent these baseline tests; 11 were retested during days 1, 3, 7, and 28 of an exacerbation.
  
  
  RESULTS
  Asthma exacerbations were characterised by increased asthma and cough symptoms and eosinophilic inflammation. Sputum ECP showed the largest increase and peaked later than clinical scores. Asthma scores consistently related to cough score only early in the exacerbation. Neither CRS nor cough scores related to any inflammatory marker.
  
  
  CONCLUSIONS
  In mild asthma exacerbations, eosinophilic inflammation is dominant. In asthmatic children who cough as a dominant symptom, cough heralds the onset of an exacerbation and increased eosinophilic inflammation, but cough scores and CRS do not reflect eosinophilic airway inflammation.
authors.affiliation: Flinders University NT Clinical School, Alice Springs Hospital, Northern Territory Department of Respiratory Medicine, Mater Children's Hospital Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW. abchang@mac.com
authors.forename: A B
authors.initials: AB
authors.lastname: Chang
authors.forename: V A
authors.initials: VA
authors.lastname: Harrhy
authors.forename: J
authors.initials: J
authors.lastname: Simpson
authors.forename: I B
authors.initials: IB
authors.lastname: Masters
authors.forename: P G
authors.initials: PG
authors.lastname: Gibson
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001249:Asthma / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D001991:Bronchitis / Q000209:etiology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003371:Cough / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011657:Pulmonary Eosinophilia / Q000473:pathology / Q000503:physiopathology; D011788:Quality of Life; D013183:Sputum / Q000737:chemistry; D014797:Vital Capacity