Analytical construct resins for analysis of solid-phase chemistry.
Rapid and unambiguous analysis of reactions performed on resin supports can be achieved by using "analytical constructs". These resins allow the synthesis of materials using solid-phase methods in the usual manner, but they also contain functionality enabling cleavage of analytically enhanced derivatives of the resin-bound products. This is possible due to the use of two linkers bound in series to the polymer. Cleavage at the first linker yields the products attached to an analytical enhancer that facilitates detection. Orthogonal cleavage at the second linker yields the desired products in the usual manner.
Congreve
Miles S
MS
GlaxoSmithKline-Cambridge Chemistry Laboratory University Chemical Laboratories, Lensfield Road Cambridge, CB2 1EW, UK.
Ley
Steven V
SV
Scicinski
Jan J
JJ
D004396:Coloring Agents; D020650:Combinatorial Chemistry Techniques; D004353:Drug Evaluation, Preclinical; D007202:Indicators and Reagents; D007700:Kinetics; D012116:Resins, Plant / Q000737:chemistry*
D004396:Coloring Agents; D007202:Indicators and Reagents; D012116:Resins, Plant