Diagnosis of a vulvar granular cell tumor by fine needle aspiration biopsy. A case report.
BACKGROUND
Granular cell tumor (GCT) (granular cell "myoblastoma") is an uncommon neoplasm that may mimic carcinoma both clinically and morphologically. Fine needle aspiration diagnosis of vulvar GNT has been described on only one prior occasion.


METHODS
A 74-year-old, black female presented with a mass in the left labia. Fine needle aspiration biopsy revealed rare intact cells; abundant, granular, cytoplasmic fragments; and bland, ovoid, stripped nuclei. The intact cells were arranged in loose aggregates. Each sampling was exquisitely painful to the patient despite the use of local anesthesia.


CONCLUSIONS
Cytologists should be aware of the distinctive clinical and morphologic appearance of GCT. The cytologic findings of vulvar, GCT are identical to those described at other body sites. Definitive diagnosis before extirpation permits definitive therapy.
Hale
Janet L
JL
Department of Cytopathology, Methodist Clinical Laboratory, Clarian Health, AmeriPath of Indiana, Department of Pathology, Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Schwenk
G Rudolph
GR
Wilson
David B
DB
Moriarty
Ann T
AT
Crabtree
William N
WN
D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D016586:Granular Cell Tumor / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000473:pathology*