Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism.
We describe the ANCA profile of two monozygotic triplets (A and B) treated with propylthiouracil (PTU) for hyperthyroidism who developed LE-like manifestations. Triplet C also developed hyperthyroidism but was not treated with PTU and never experienced LE-like symptoms. Triplet A and B showed a marked rise in P-ANCA titer to 1:1280 after PTU was introduced whereas triplet C never had a titer higher than 1:80. Consecutive sera were investigated for ANCA to six different neutrophil granule proteins. Triplet A and B, but not C, both developed a strongly positive elastase-ANCA. Our results confirm the importance of a genetic factor influencing the susceptibility to drug-induced LE.
Herlin
Troels
T
Department of Pediatrics, Skejby Sygehus, Aarhus University Hospital, Denmark. t.herlin@dadlnet.dk
Birkebaek
Niels H
NH
Wolthers
Ole D
OD
Heegaard
Niels H H
NH
Wiik
Allan
A
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D013956:Antithyroid Agents / Q000009:adverse effects*; D002648:Child; D006650:Histocompatibility Testing; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000139:chemically induced*; D011441:Propylthiouracil / Q000009:adverse effects*; D014310:Triplets
D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D011441:Propylthiouracil