Biosynthesis of hibarimicins. III. Structures of new hibarimicin-related metabolites produced by blocked mutants.
Structures of metabolites produced by blocked mutants of Microbispora rosea subsp. hibaria TP-A0121, hibarimicin-producer, were determined by spectroscopic analysis. HMP-Y6 is the dimer of the west half of hibarimicin B, the aglycon of which is the genuine biosynthetic intermediate. HMP-P1 is the shunt product arising from the release of a methanol molecule from hibarimicinone. HMP-P4, the glycoside of HMP-P1, is glycosylated with two amicetoses and two digitoxoses same as hibarimicin B. HMP-M1, M2, M3 and M4 are shunt products derived from the monomeric undecaketide intermediates.
Igarashi
Yasuhiro
Y
Biotechnology Research Center, Toyama Prefectural University, Kosugi, Toyama, Japan. yas@pu-toyama.ac.jp
Kajiura
Takayuki
T
Furumai
Tamotsu
T
Hori
Hiroshi
H
Higashi
Kazuaki
K
Ishiyama
Tadayuki
T
Uramoto
Masakazu
M
Uehara
Yoshimasa
Y
Oki
Toshikazu
T
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D016296:Mutagenesis; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents