title: CJ-15,696 and its analogs, new furopyridine antibiotics from the fungus Cladobotryum varium: fermentation, isolation, structural elucidation, biotransformation and antibacterial activities.
abstract: CJ-15,696 and 7 novel furopyridine antibiotics were isolated from the fungus Cladobotryum varium CL12284. Their structures were determined by X-ray crystallography and spectral analysis. Three biotransformed analogs were also prepared from CJ-15,696. CJ-15,696 showed moderate activity against various Gram-positive bacteria including some drug resistant strains such as methicillin resistant Staphylococcus aureus (MRSA).
authors.affiliation: Exploratory Medicinal Sciences, Pfizer Global Research and Development (PGRD)--Nagoya Laboratories, Pfizer Inc., Aichi, Japan. Shinichi.Sakemi@japan.pfizer.com
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sakemi
authors.forename: Jon
authors.initials: J
authors.lastname: Bordner
authors.forename: Debra L
authors.initials: DL
authors.lastname: DeCosta
authors.forename: Koen A
authors.initials: KA
authors.lastname: Dekker
authors.forename: Hideo
authors.initials: H
authors.lastname: Hirai
authors.forename: Taisuke
authors.initials: T
authors.lastname: Inagaki
authors.forename: Yoon-Jeong
authors.initials: YJ
authors.lastname: Kim
authors.forename: Nakao
authors.initials: N
authors.lastname: Kojima
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Sims
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sugie
authors.forename: Akemi
authors.initials: A
authors.lastname: Sugiura
authors.forename: Joyce A
authors.initials: JA
authors.lastname: Sutcliffe
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Tachikawa
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Truesdell
authors.forename: John W
authors.initials: JW
authors.lastname: Wong
authors.forename: Nobuji
authors.initials: N
authors.lastname: Yoshikawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kojima
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001711:Biotransformation; D005285:Fermentation; D006094:Gram-Positive Bacteria; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents