Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites.
A unique pentaketide dimer structure of a novel fungal metabolite with antiangiogenic activity, designated as epoxyquinol A (1), was determined on the basis of NMR spectral data as well as the X-ray crystallographic analysis. 1 inhibits the endothelial migration induced by vascular endothelial growth factor (ED100 = 3 mug/mL).
Kakeya
Hideaki
H
Antibiotics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Onose
Rie
R
Koshino
Hiroyuki
H
Yoshida
Arika
A
Kobayashi
Kimiko
K
Kageyama
Shun-Ichiro
S
Osada
Hiroyuki
H
D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry*; D006873:Hydroquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D012988:Soil Microbiology
D020533:Angiogenesis Inhibitors; D004852:Epoxy Compounds; D006873:Hydroquinones; C455959:epoxyquinol A