title: Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder.
abstract: Several lines of evidence implicate synaptosomal-associated protein of 25 kDa (SNAP-25) in the etiology of attention deficit hyperactivity disorder (ADHD). Most notably, the coloboma mouse mutant, considered to be a good animal model of hyperactivity, has a deletion spanning this gene. Introducing a SNAP-25 transgene into these animals alleviates hyperlocomotion. We have identified a novel microsatellite repeat in SNAP-25 located between the 5'UTR and the first coding exon, and tested for association with ADHD. Case-control analyses suggest there may be a role of this polymorphism in ADHD, with one allele over-represented in controls and another over-represented in probands. Within-family tests of linkage and association confirmed these findings. Further work is needed to ascertain the role of SNAP-25 in ADHD and assess the functional significance of this polymorphism.
authors.affiliation: Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom. j.mill@iop.kcl.ac.uk
authors.forename: Jonathan
authors.initials: J
authors.lastname: Mill
authors.forename: Sarah
authors.initials: S
authors.lastname: Curran
authors.forename: Lindsey
authors.initials: L
authors.lastname: Kent
authors.forename: Alison
authors.initials: A
authors.lastname: Gould
authors.forename: Louise
authors.initials: L
authors.lastname: Huckett
authors.forename: Sandra
authors.initials: S
authors.lastname: Richards
authors.forename: Eric
authors.initials: E
authors.lastname: Taylor
authors.forename: Philip
authors.initials: P
authors.lastname: Asherson
mesh_terms: D000483:Alleles; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D018895:Microsatellite Repeats / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D050825:Synaptosomal-Associated Protein 25
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C494208:SNAP25 protein, human; D050825:Synaptosomal-Associated Protein 25