title: [Study of levels of antibody against coxsackievirus B in different adults in Changsha area].
abstract: In order to verify the antibody levels against coxsackievirus B(CVB) in different adults, specific anti-CVB-IgM and anti-CVB-IgG have been detected in 46 viral myocarditis, 121 viral-hepatitis patients and 108 healthy donors by using immuno-enzyme histochemical method, and the antibody titres were also tested. The results showed that the positive rate of anti-CVB in viral myocarditis group, viral hepatitis group and donor group were 80.4% (37/46), 25.6% (31/121) and 40.7% (44/108), respectively. The GMT of anti-CVB-IgM and anti-CVB-IgG in viral myocarditis group, hepatitis group and donor group were 1:84.84, 1:9.07, 1:64.00 and 1:179.27, 1:9.59, 1:21.42, respectively. The positive rate and GMT of anti-CVB-IgM and anti-CVB-IgG in viral myocarditis group were significantly higher than those in the other two groups. The positive rate had no statistical difference between men and women. The results indicate that the majority of the healthy population in Changsha area is susceptible for CVB and most cases of the viral myocarditis many be related to CVB infection. It is considered that CVB can cause many diseases. Furthermore, there are no effective vaccine against CVB so far. One should think of the probability of CVB infection when encountering a patient.
authors.affiliation: Department of Epidemiology, Hunan Medical University, Changsha 410008.
authors.forename: M
authors.initials: M
authors.lastname: Xie
authors.forename: H
authors.initials: H
authors.lastname: Tan
authors.forename: P
authors.initials: P
authors.lastname: Pu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D002681:China / Q000453:epidemiology; D003384:Coxsackievirus Infections / Q000453:epidemiology*; D029822:Enterovirus B, Human / Q000276:immunology / Q000302:isolation & purification*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000821:virology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M