title: [Steroid sprays in non-infectious rhinitis and sinusitis. Proper and regular spraying does not damage the nasal mucosa].
abstract: Glucocorticoids are an effective therapeutic option for most forms of non-infectious rhinitis and sinusitis. In Germany, dexamethasone, beclomethasone diproprionate, flunisolide, fluocortin butyl ester, budesonide, fluticasone proprionate, triamcinolone acetonide and mometasone furoate are available for nasal application. The action of these drugs is mediated by cytoplasmic receptors (glucocorticoid receptors). In addition, receptor-independent immediate effects are also known. To ensure optimal efficacy of corticoid sprays, detailed patient instruction is of importance, with particular emphasis being placed on the correct spraying technique and regular application. Modern preparations are associated with very few side effects. There is no evidence that mucosal atrophy occurs.
authors.affiliation: Zentrum für Rhinologie und Allergologie, Wiesbaden, und HNO-Universitätsklinik, Mannheim. Ludger.Klimek@t-online.de
authors.forename: L
authors.initials: L
authors.lastname: Klimek
authors.forename: C
authors.initials: C
authors.lastname: Bachert
authors.forename: K
authors.initials: K
authors.lastname: Hörmann
mesh_terms: D000281:Administration, Intranasal; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D005938:Glucocorticoids; D006801:Humans; D009297:Nasal Mucosa / Q000187:drug effects; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids
vernacular_title: Steroidsprays bei nicht infektiöser Rhinitis und Sinusitis. Richtig und regelmässig sprühen schadet der Schleimhaut nicht.