Cystic fibrosis in a child from Syria.
We describe a Syrian child with typical features of severe cystic fibrosis (CF) phenotype and a positive sweat test. DNA analysis confirmed homozygosity for the delta F508 mutation on chromosome 7. This report stresses the need to draw attention to and consider CF in Arab populations. The frequency and distribution of delta F508 in the Middle East are reviewed.
Wahab
A Abdul
AA
Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar. atiqa@qatar.net.qa
Janahi
I A
IA
Hebi
S
S
al-Hamed
M
M
Kambouris
M
M
D018912:Arabs; D002897:Chromosomes, Human, Pair 7; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000208:ethnology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D009154:Mutation; D013593:Syria
C505032:CFTR protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator