title: Synthesis and structure-activity relationship of diarylamide urea derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells.
abstract: A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2o was superior to the lead compound, Tranilast, in terms of its potency of the inhibitory activity and cell selectivity.
authors.affiliation: Pharmaceuticals & Biotechnology Laboratory, Japan Energy Corporation, 3-17-35, Niizo-Minami, Saitama 335-8502, Toda-shi, Japan.
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Ogita
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Isobe
authors.forename: Haruo
authors.initials: H
authors.lastname: Takaku
authors.forename: Rena
authors.initials: R
authors.lastname: Sekine
authors.forename: Yuso
authors.initials: Y
authors.lastname: Goto
authors.forename: Satoru
authors.initials: S
authors.lastname: Misawa
authors.forename: Hideya
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D001158:Arteries / Q000166:cytology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003331:Coronary Vessels / Q000166:cytology*; D004247:DNA / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D032389:Myocytes, Smooth Muscle / Q000166:cytology* / Q000187:drug effects*; D010671:Phenylurea Compounds / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D010671:Phenylurea Compounds; D004247:DNA