[Blood fatty acid transporters in acute pancreatitis].
A relationship between of acute pancreatitis severity and concentrations of blood transporters of nonesterified fatty acids (albumin) and esterified fatty acids (lipoproteins) was studied. In necrotizing pancreatitis, there was a positive correlation between decrease of albumin and lipoprotein concentrations in serum, but no correlation was in edematous pancreatitis. High levels of serum albumin (> 32 g/L) and lipoproteins (cholesterol + triglycerides, CH + TG, > 260 mg/dL) had good prognostic value in terms of favourable development of this disease, whereas lower concentrations indicated unfavourable prognosis. Both albumin and lipoproteins appeared in the peritoneal exsudate where they represented 73 and 53% of the serum concentrations, respectively. Albumin efflux from blood to the exsudate correlated with lipoprotein efflux (r = 0.7) in necrotizing pancreatitis. The latter suggests that proteins penetrated together the tissue barrier blood/peritoneal space. The less albumin and lipoprotein concentrations in serum, the more they are in the exsudate (r = -0.57 and -0.47, respectively); probably, their concentration decrease in blood is due to to their efflux into the exsudate.
Rodoman
G V
GV
Research Institute for Physical Chemical Medicine, Russia State Medical University, Moscow.
Shalaeva
T I
TI
Dobretsov
G E
GE
D000208:Acute Disease; D001692:Biological Transport; D005122:Exudates and Transudates / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism*; D010195:Pancreatitis / Q000097:blood / Q000175:diagnosis / Q000378:metabolism*; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood / Q000175:diagnosis / Q000378:metabolism; D010529:Peritoneal Cavity; D012709:Serum Albumin / Q000378:metabolism*
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D008074:Lipoproteins; D012709:Serum Albumin
Perenoschiki zhirnykh kislot v krovi pri ostrom pankreatite.