[The effects of BDP on calcium ion in the granular leukocytes in nasal secretions of the patients with allergic rhinitis].
OBJECTIVE
To study the effects of beclomethasone dipropionate (BDP) on the inflammatory granular leukocytes in nasal secretions of the patients with allergic rhinitis.


METHODS
The change of intercellular calcium ion of the eosinophils and neutrophils in the nasal secretions were observed under the laser scanning confocal microscopy and technology of fluorescence.


RESULTS
The concentration of intercellular calcium ion either in eosinophils or in neutrophils significantly rose after BDP treatment.


CONCLUSIONS
BDP can rise the concentration of intercellular calcium ion in the granular leukocytes, which may be a factor of the anti-inflammation functions of BDP.
Shen
Zhizhong
Z
Department of Otolaryngology, First Affiliated Hospital of Shantou University Medical College, Shantou 515041.
Wang
Hao
H
Wang
Huige
H
Lin
Juelong
J
Chen
Yaowen
Y
Song
Dehui
D
D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001507:Beclomethasone / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D004804:Eosinophils / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D009297:Nasal Mucosa / Q000378:metabolism*; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D001507:Beclomethasone; D002118:Calcium