[The protective effects of total flavonoids from Lycium Barbarum L. on lipid peroxidation of liver mitochondria and red blood cell in rats].
The protective effects of total flavonoids from Lycium Barbarum L. (TFL) on lipid peroxidation in mitochondria and red blood cells (RBC) induced by oxygen radicals produced by Fe2+ cysteine system were investigated. The mitochondria lipid peroxidation (measured as malondialdehyde, MDA) was significantly inhibited by TFL with a dose-response relation between the concentrations of 0.025 and 2.0 mg/ml, and the fluidity of mitochondria membrane was also protected effectively. It was observed by scan electron microscope, that the shape of RBC in the Fe2+ system was damaged significantly. The shape of RBC was remained with the addition of TFL.
Huang
Y
Y
Department of Nutrition and Food Hygiene, Faculty of Preventive Medicine, Ningxia Medical College, Yinchuan 750004, China.
Lu
J
J
Shen
Y
Y
Lu
J
J
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D004912:Erythrocytes / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D032305:Lycium / Q000737:chemistry*; D008315:Malondialdehyde / Q000378:metabolism; D008560:Membrane Fluidity; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D008315:Malondialdehyde