Chronic social stress during puberty enhances tyrosine hydroxylase immunoreactivity within the limbic system in golden hamsters.
The present study was carried out to determine the effects of chronic exposure to social stress during puberty on the dopamine system in male golden hamsters. Experimental animals were socially subjugated between postnatal days 28 (P28) and 42. All animals were sacrificed on P46 and their brains processed for immunocytochemistry to tyrosine hydroxylase (TH). A large increase in the number of TH-immunoreactive (TH-ir) neurons was noted within the posterior portion of the medial amygdaloid nucleus and the posterior portion of the medial division of the bed nucleus of the stria terminalis in subjugated animals as compared to controls. This effect appeared to be site-specific as no difference was seen between groups in the periventricular nucleus, another steroid receptor-rich area. The data suggest that these dopamine neurons may play an important role in the behavioral changes associated with chronic social stress during puberty.
Wommack
Joel C
JC
Psychology Department and Institute for Neuroscience, Mezes 330, The University of Texas at Austin, Austin, TX 78712, USA. joelwommack@aol.com
Delville
Yvon
Y
D000375:Aging / Q000378:metabolism; D000679:Amygdala / Q000166:cytology / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D002908:Chronic Disease; D006224:Cricetinae; D004298:Dopamine / Q000096:biosynthesis*; D005260:Female; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism; D007150:Immunohistochemistry; D008032:Limbic System / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D009434:Neural Pathways / Q000166:cytology / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000201:enzymology; D009929:Organ Size / Q000502:physiology; D012686:Septal Nuclei / Q000166:cytology / Q000378:metabolism; D012919:Social Behavior; D013315:Stress, Psychological / Q000201:enzymology* / Q000503:physiopathology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D015854:Up-Regulation / Q000502:physiology*
D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine