Four highly oxygenated isopimarane-type diterpenes of Orthosiphon stamineus.
Four highly oxygenated isopimarane-type diterpenes, named orthosiphols O, P and Q and nororthosiphonolide A, have been isolated from the aerial parts of Orthosiphon stamineus from Myanmar, together with three known diterpenes, orthosiphols D and E and orthosiphonone A. Their structures were determined on the basis of extensive spectral analysis. All the isolated compounds displayed mild antiproliferative activities against highly liver metastatic colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cell lines.
Awale
Suresh
S
Tezuka
Yasuhiro
Y
Banskota
Arjun H
AH
Kouda
Kyoji
K
Tun
Kyaw Myint
KM
Kadota
Shigetoshi
S
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D019686:Lamiaceae; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004224:Diterpenes; D010936:Plant Extracts; C458723:nororthosiphonolide A; C458726:orthosiphol O; C458724:orthosiphol P; C458725:orthosiphol Q