title: Onychomycosis due to Exophiala jeanselmei.
abstract: BACKGROUND
  Exophiala jeanselmei is a dematiaceous fungus that may cause invasive diseases, particularly among immunocompromised hosts. Most reports mention cutaneous or subcutaneous lesions, but no case of nail involvement due to this fungus has been reported until now.
  
  
  METHODS
  A 60-year-old man presented with hyperkeratosis and black coloration of the nails of the two thumbs and the two big toes of 4 years' duration. He was a renal transplant recipient and had been treated with prednisone and azathioprine. E. jeanselmei was present on direct examination, then isolated in cultures on repeated samplings from all pathologic nails. He was cured after 6 months of treatment with itraconazole.
  
  
  CONCLUSIONS
  We describe the first case of nail infection due to E. jeanselmei. Itraconazole, which provides a broad spectrum of action on fungal species and achieves high levels of active substance in many tissues, including the nails, appeared to be efficient upon such a nail localization of E. jeanselmei.
authors.affiliation: Service de Dermatologie, Centre Hospitalier Universitaire de Fort de France, Martinique, France. garsaud@sasi.fr
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Boisseau-Garsaud
authors.forename: Nicole
authors.initials: N
authors.lastname: Desbois
authors.forename: Marie-Laurence
authors.initials: ML
authors.lastname: Guillermin
authors.forename: Marlène
authors.initials: M
authors.lastname: Ossondo
authors.forename: Evelyne
authors.initials: E
authors.lastname: Gueho
authors.forename: Danielle
authors.initials: D
authors.lastname: Cales-Quist
mesh_terms: D005093:Exophiala / Q000302:isolation & purification*; D006229:Hand Dermatoses / Q000382:microbiology / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009262:Nails / Q000473:pathology; D014009:Onychomycosis / Q000382:microbiology* / Q000473:pathology