title: Increased plasma HB-EGF associated with obesity and coronary artery disease.
abstract: The mechanism by which the obese subjects are more associated with vascular disease remains unclear. We reported that the adipose tissues produce and secrete many bioactive molecules, conceptualized as adipocytokines. Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF), produced locally by vascular macrophages and smooth muscle cells, has been suggested to induce the migration and proliferation of vascular smooth muscle cells. The current study reveals that (1) HB-EGF mRNA is abundantly expressed in human adipose tissue, (2) HB-EGF mRNA increases in the fat tissues of obese mice, (3) plasma HB-EGF levels increase in parallel with fat accumulation in human, and (4) the subjects with coronary artery disease have higher plasma HB-EGF levels, associated with fat accumulation. These results suggest that increased plasma HB-EGF derived from the accumulated fat contributes to the higher incidence of vascular disease in obesity, proposing HB-EGF as an adipocytokine directly linking adipovascular axis.
authors.affiliation: Department of Internal Medicine and Molecular Science, Graduate School of Medicine, B5, Osaka University, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Ken
authors.initials: K
authors.lastname: Kishida
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
authors.forename: Norikazu
authors.initials: N
authors.lastname: Maeda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nagaretani
authors.forename: Morihiro
authors.initials: M
authors.lastname: Matsuda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nishizawa
authors.forename: Shinji
authors.initials: S
authors.lastname: Kihara
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsuzawa
authors.forename: A
authors.initials: A
authors.lastname: Yamada
authors.forename: S
authors.initials: S
authors.lastname: Yamashita
authors.forename: S
authors.initials: S
authors.lastname: Tamura
authors.forename: S
authors.initials: S
authors.lastname: Kawata
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000818:Animals; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology; D004815:Epidermal Growth Factor / Q000097:blood* / Q000235:genetics; D066257:Heparin-binding EGF-like Growth Factor; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice; D008820:Mice, Obese; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D012313:RNA / Q000378:metabolism; D013223:Statistics as Topic; D014018:Tissue Distribution
chemical_list: C587883:HBEGF protein, human; C587884:Hbegf protein, mouse; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D004815:Epidermal Growth Factor; D012313:RNA