title: Results of cerebrospinal fluid analysis, neurologic examination findings, and age at the onset of seizures as predictors for results of magnetic resonance imaging of the brain in dogs examined because of seizures: 115 cases (1992-2000).
abstract: OBJECTIVE
  To determine whether neurologic examination findings, results of CSF analysis, or age at the onset of seizures could be used to predict whether results of magnetic resonance imaging (MRI) would be normal or abnormal in dogs with seizures.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  115 dogs.
  
  
  METHODS
  Information on results of neurologic examination, results of CSF analysis, age at the onset of seizures, and results of MRI was obtained from the medical records.
  
  
  RESULTS
  Results of MRI were abnormal in 61 dogs and normal in 54. Sensitivity and specificity of neurologic examination alone were 77 (47/61) and 91% (49/54), respectively. Sensitivity and specificity of CSF analysis alone were 79 (48/61) and 69% (37/54), respectively. Results of MRI were abnormal for 12 of 28 (43%) dogs with abnormal CSF analysis results and normal neurologic examination results but for only 2 of 35 (6%) dogs with normal CSF analysis and normal neurologic examination results. Similarly, results of MRI were abnormal for 36 of 37 (97%) dogs with abnormal CSF analysis and abnormal neurologic examination results but for only 11 of 15 (73%) dogs with normal CSF analysis results and abnormal neurologic examination results. Age at the onset of seizures (< 6 vs > or = 6 years old) was not significantly associated with results of MRI.
  
  
  CONCLUSIONS
  Results suggest that neurologic examination findings and results of CSF analysis are useful in predicting whether results of MRI will be abnormal in dogs examined because of seizures, but age at the onset of seizures is not.
authors.affiliation: Department of Neurology, Veterinary Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: William W
authors.initials: WW
authors.lastname: Bush
authors.forename: Christina S
authors.initials: CS
authors.lastname: Barr
authors.forename: Edwin W
authors.initials: EW
authors.lastname: Darrin
authors.forename: Frances S
authors.initials: FS
authors.lastname: Shofer
authors.forename: Charles H
authors.initials: CH
authors.lastname: Vite
authors.forename: Sheldon A
authors.initials: SA
authors.lastname: Steinberg
mesh_terms: D017668:Age of Onset; D000818:Animals; D001921:Brain / Q000473:pathology*; D002452:Cell Count / Q000662:veterinary; D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000166:cytology; D002556:Cerebrospinal Fluid Proteins / Q000134:cerebrospinal fluid; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005260:Female; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D009460:Neurologic Examination / Q000662:veterinary; D012372:ROC Curve; D012189:Retrospective Studies; D012640:Seizures / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D012680:Sensitivity and Specificity
chemical_list: D002556:Cerebrospinal Fluid Proteins