Immunisations in solid-organ transplant recipients.
Solid-organ transplant recipients are at increased risk of various infectious diseases, some of which are vaccine preventable mmunisations are among the most efficient interventions available. Solid-organ tranplant recipients would greatly benefit from effective immunisations, provided the recommendations are based on a careful risk-benefit analysis in which the effectiveness of the vaccine is weighed against possible adverse reactions, including graft rejection. In this review, we summarise the data from studies on relevant immunisations in solid-organ transplant recipients. The major issues are the immunogenicity and safety of immunisations, the factors associated with poor immune response, and recommendations for immunisation schemes.
Stark
Klaus
K
Institute of Tropical Medicine, Charité, Humboldt University, Berlin, Germany. starkk@rki.de
Günther
Matthias
M
Schönfeld
Christian
C
Tullius
Stefan G
SG
Bienzle
Ulrich
U
D000328:Adult; D001424:Bacterial Infections / Q000517:prevention & control*; D004334:Drug Administration Schedule; D006084:Graft Rejection / Q000139:chemically induced; D006801:Humans; D011184:Postoperative Period; D018570:Risk Assessment; D014181:Transplantation Immunology / Q000187:drug effects / Q000276:immunology; D014612:Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D014777:Virus Diseases / Q000517:prevention & control*
D014612:Vaccines