Evaluation of toxic activity of 2,4-dihydroxythiobenzanilides.
2,4-Dihydroxythiobenzanilides represent a new group of compounds with significant fungistatic and bacteriostatic properties. The results of investigations on their cytotoxicity are also very convincing. Therefore LD50 doses were determined for five compounds, they ranged from 239 to 840.5 mg/kg. The results of the tests for spontaneous locomotor activity and hexabarbiturane sleeping time indicate low toxicity of the compounds tested.
Kleinrok
Z
Z
Department of Pharmacology, Medical Academy, University of Agriculture, Lublin, Poland.
Niewiadomy
A
A
Matysiak
J
J
D000813:Anilides / Q000633:toxicity*; D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D000935:Antifungal Agents / Q000633:toxicity*; D000970:Antineoplastic Agents / Q000633:toxicity*; D002415:Cats; D002460:Cell Line; D006591:Hexobarbital / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013055:Spectrophotometry, Infrared
D000813:Anilides; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D006993:Hypnotics and Sedatives; D006591:Hexobarbital