title: Interleukin-2 in the pathogenesis of perinatal white matter damage.
abstract: Proinflammatory cytokines were reported to be implicated in the pathogenesis of perinatal white matter lesions. The authors document for the first time the in situ detection of interleukin-2 and interleukin-2 receptor (IL-2R) in these human white matter lesions. These results suggest that interleukin-2, reported to be toxic to oligodendrocytes and myelin, could play a role in the molecular cascade leading to white matter damage in periventricular leukomalacia.
authors.affiliation: Laboratoire de Neurologie du Développement, Université Catholique de Louvain, Brussels, Belgium. Hazim.Kadhim@nepe.ucl.ac.be
authors.forename: H
authors.initials: H
authors.lastname: Kadhim
authors.forename: B
authors.initials: B
authors.lastname: Tabarki
authors.forename: C
authors.initials: C
authors.lastname: De Prez
authors.forename: A-M
authors.initials: AM
authors.lastname: Rona
authors.forename: G
authors.initials: G
authors.lastname: Sébire
mesh_terms: D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D016207:Cytokines / Q000032:analysis / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn / Q000378:metabolism*; D007234:Infant, Premature / Q000378:metabolism; D007376:Interleukin-2 / Q000032:analysis / Q000096:biosynthesis*; D008297:Male; D018709:Statistics, Nonparametric
chemical_list: D016207:Cytokines; D007376:Interleukin-2