[Affection of aprotinin on tissue factor pathway inhibitor in peri-operation of cardiac direct vision operation].
Twenty patients underwent cardiac operation with cardiopulmonary bypass(CPB). We collected their blood samples during peri-operation and measured tissue factor pathway inhibitor(TFPI) and active coagulation time(ACT). The results were that TFPI and ACT were significantly increased after heparin injection and during CPB. The changes of TFPI and ACT were similar and pathophysiological; it was evident that heparin stimulated TFPI release and ACT prolonged during cardiac operation with CPB. Aprotinin did not affect the change of TFPI. The results suggest that TFPI has the effect on anticoagulation during CPB.
Chen
S
S
Department of Cardiothoracic Surgery, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Li
G
G
Xu
L
L
He
Z
Z
D000293:Adolescent; D000328:Adult; D007611:Aprotinin / Q000494:pharmacology*; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D005260:Female; D005343:Fibrinolytic Agents / Q000378:metabolism*; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006801:Humans; D007432:Intraoperative Period; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D014914:Whole Blood Coagulation Time
D005343:Fibrinolytic Agents; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D007611:Aprotinin