title: Antioxidant potential of a novel tetrapeptide derivative in isoproterenol-induced myocardial necrosis in rats.
abstract: A novel tetrapeptide derivative Boc-Lys(Boc)-Arg-Asp-Ser(tbu)-OtBu (PEP1261) has been tested in vivo in isoproterenol (ISO) hydrochloride (HCl)-induced myocardial necrosis in rats. ISO x HCl induces myocardial necrosis in rats which is accompanied by the distinct increase in heart weight, marked electrocardiographic changes, increase in the levels of serum marker enzymes and lipid peroxides and decrease in the levels of antioxidants. PEP1261 (5 mg/kg body weight i.p.) pre- and post-treatment effectively decreases serum marker enzyme levels, while the electrocardiographic changes get restored towards normalcy. PEP1261 also inhibits the action of the free radicals toxicity by increasing the levels of antioxidants and histological studies confirm the above findings. This study shows that PEP1261 could serve as an excellent cardioprotective agent possessing membrane-stabilizing action.
authors.affiliation: Department of Biotechnology, Central Leather Research Institute, Adyar, Chennai, India.
authors.forename: Panchatcharam
authors.initials: P
authors.lastname: Manikandan
authors.forename: Miriyala
authors.initials: M
authors.lastname: Sumitra
authors.forename: Dilly Ashok
authors.initials: DA
authors.lastname: Kumar
authors.forename: Chandrasekar
authors.initials: C
authors.lastname: Gayathri
authors.forename: Natarajan
authors.initials: N
authors.lastname: Arutselvan
authors.forename: Bhakthavatsalam Murali
authors.initials: BM
authors.lastname: Manohar
authors.forename: Rengarajulu
authors.initials: R
authors.lastname: Puvanakrishnan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D007545:Isoproterenol / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D009336:Necrosis; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D009842:Oligopeptides; D007545:Isoproterenol