Treatment of gram-positive infections: past, present, and future.
The need for strategic planning for antimicrobial use has reached a critical point. The rise in resistant nosocomial and community gram-positive bacteria mandates appropriate antibiotic selection and dosing. The development of new compounds is not the answer, because many are based off existing structures to which bacteria have already developed resistance. New antimicrobial agents are falling to the resistant mechanisms developed by the bacteria, after only limited clinical exposure. Judicious use of antimicrobial agents and applying pharmacokinetic principles when dosing can help slow the rate of resistance.
Weston
Jaye S
JS
Department of Pharmacy, East Texas Medical Center, Tyler 75711, USA. jweston@etmc.org
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D004351:Drug Resistance; D006094:Gram-Positive Bacteria / Q000145:classification / Q000472:pathogenicity; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans
D000900:Anti-Bacterial Agents