Optical rotatory dispersion properties of nucleic acid complexes with the oligopeptide antibiotics distamycin A and netropsin.
ORD measurements of nucleic acids in the presence of the oligopeptides netropsin and distamycin A have indicated association of the antibiotics with DNA and strong conformational changes of the DNA structure with specificity to AT-rich helical regions. The RNA conformation is relatively unaffected by these antibiotics. The results are explained in terms of a perturbation of the DNA secondary structure as well as of the chromophore system of the oligopeptides.
Zimmer
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Abteilung Biochemie, Zentralinstitut für Mikrobiologie und experimentelle Therapie der Deutschen Akademie der Wissenschaften zu Berlin, DDR-69, Beuthenbergstr. 11, Jena, G.D.R.
Luck
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