title: Design of peptides with alpha,beta-dehydro residues: pseudo-tripeptide N-benzyloxycarbonyl-DeltaLeu-L-Ala-L-Leu-OCH3.
abstract: The title peptide N-benzyloxycarbonyl-DeltaLeu-L-Ala-L-Leu-OCH(3) [methyl N-(benzyloxycarbonyl)-alpha,beta-dehydroleucyl-L-alanyl-L-leucinate], C(24)H(35)N(3)O(6), was synthesized in the solution phase. The peptide adopts a type II' beta-turn conformation which is stabilized by an intramolecular 4 --> 1 N-H* * *O hydrogen bond. The crystal packing is stabilized by two intermolecular N-H* * *O hydrogen bonds.
authors.affiliation: Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Makker
authors.forename: Sharmistha
authors.initials: S
authors.lastname: Dey
authors.forename: Pravindra
authors.initials: P
authors.lastname: Kumar
authors.forename: Tej P
authors.initials: TP
authors.lastname: Singh
mesh_terms: D018360:Crystallography, X-Ray; D015195:Drug Design; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; C459720:N-benzyloxycarbonyl-DeltaLeu-L-Ala-L-Leu-OCH3; D009842:Oligopeptides