title: Nondissecting aneurysm of the thoracic aorta with arteritis in systemic lupus erythematosus.
abstract: A nondissecting aneurysm of the distal descending thoracic aorta, 55 mm in diameter, in a 35-year-old woman who was undergoing 24-year steroid therapy of systemic lupus erythematosus was successfully resected and replaced with a tube graft. The suture line of the aortic wall was reinforced with a polytetrafluoroethylene felt strip. Histologically, the media and adventitia contained numerous lymphoplasmacytic infiltrates that consisted of B and activated T cells mixed with plasmacytes. These findings would have been in accordance with active aortitis. Systemic lupus erythematosus was suggested as possibly associated with nondissecting thoracic aortic aneurysm, especially in patients undergoing chronic steroid therapy in which inflammation continued.
authors.affiliation: First Department of Surgery, Gifu University School of Medicine, Japan. h-takagi@cc.gifu-u.ac.jp
authors.forename: Hisato
authors.initials: H
authors.lastname: Takagi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Mori
authors.forename: Hisashi
authors.initials: H
authors.lastname: Iwata
authors.forename: Masaki
authors.initials: M
authors.lastname: Kimura
authors.forename: Mansyo
authors.initials: M
authors.lastname: Itokazu
authors.forename: Kuniyasu
authors.initials: K
authors.lastname: Shimokawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Hirose
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001013:Aorta, Thoracic / Q000473:pathology; D017545:Aortic Aneurysm, Thoracic / Q000150:complications* / Q000473:pathology / Q000601:surgery; D001025:Aortitis / Q000150:complications* / Q000473:pathology; D019917:Blood Vessel Prosthesis Implantation; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D013256:Steroids; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D013256:Steroids