Prevalence of interleukin 1 periodontal genotype in a Hispanic dental population.
OBJECTIVE
A genetic polymorphism in the interleukin 1 gene has been implicated as a factor in determining the severity of adult periodontitis. Among white Europeans, the prevalence of genotype-positive subjects has been reported to be around 30%. The purpose of this study was to assess the prevalence of genotype-positive individuals in a Hispanic population.


METHODS
Fifty Mexicans were evaluated for their interleukin 1 genotype with a commercially available test. Subjects were divided into groups, as determined by their genotype (positive or negative), and were then analyzed according to age, sex, and smoking habits.


RESULTS
Thirteen of 50 subjects were genotype positive, a prevalence of 26%. The most common polymorphisms found in genotype-positive subjects were allele 1.2 for the IL 1A gene and allele 1.2 for the IL 1B gene. When only subjects older than 30 years were evaluated, the prevalence of genotype-positive individuals was 31%.


CONCLUSIONS
The prevalence of genotype-positive subjects in a Hispanic population was 26%, similar to the prevalence found among ethnic populations from or descended from Northern, Central, and Southern Europe.
Caffesse
Raul G
RG
Division of Periodontics, University of Texas, Health Science Center at Houston, Dental Branch, Houston, Texas, USA.
De LaRosa
Manuel R
MR
De LaRosa
Manuel G
MG
Mota
Luis F
LF
D000293:Adolescent; D000328:Adult; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D017058:Mexican Americans / Q000235:genetics*; D008875:Middle Aged; D017720:Molecular Epidemiology; D010518:Periodontitis / Q000235:genetics*; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics
D007375:Interleukin-1