title: An automated computer system to support ultra high throughput SNP genotyping.
abstract: Celera Genomics has constructed an automated computer system to support ultra high-throughput SNP genotyping that satisfies the increasing demand that disease association studies are placing on current genotyping facilities. This system consists of the seamless integration of target SNP selection, automated oligo design, in silico assay quality validation, laboratory management of samples, reagents and plates, automated allele calling, optional manual review of autocalls, regular status reports, and linkage disequilibrium analysis. Celera has proven the system by generating over 2.5 million genotypes from more than 10,000 SNPs, and is approaching the target capacity of over 10,000 genotypes per machine per hour using limited human intervention with state of the art laboratory hardware.
authors.affiliation: Celera Genomics, 45 W. Gude Drive, Rockville, MD 20850, USA. Jeremy.Heil@celera.com
authors.forename: J
authors.initials: J
authors.lastname: Heil
authors.forename: S
authors.initials: S
authors.lastname: Glanowski
authors.forename: J
authors.initials: J
authors.lastname: Scott
authors.forename: E
authors.initials: E
authors.lastname: Winn-Deen
authors.forename: I
authors.initials: I
authors.lastname: McMullen
authors.forename: L
authors.initials: L
authors.lastname: Wu
authors.forename: C
authors.initials: C
authors.lastname: Gire
authors.forename: A
authors.initials: A
authors.lastname: Sprague
mesh_terms: D001331:Automation; D003199:Computer Systems; D030541:Databases, Genetic; D005838:Genotype; D006801:Humans; D007256:Information Systems; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide