title: Concurrent spinal cord and vertebral bone marrow radionecrosis 8 years after therapeutic irradiation.
abstract: Concurrent radionecrosis within the spinal cord and the bone marrow at the same thoracic level was observed 8 years after localized therapeutic irradiation in a patient who had undergone repeated cycles of radiotherapy, glucocorticoid treatment, and chemotherapy for a non-Hodgkin's lymphoma. Mechanisms combining radiotoxic potentialization by glucocorticoids/alkylating agents and delayed radiation-induced vasculitis involving the common arterial pathways to the spinal cord and to the vertebrae were speculated to have acted in a synergistic way.
authors.affiliation: Department of Neurology, Université catholique de Louvain, Cliniques universitaires Saint-Luc, Brussels, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Warscotte
authors.forename: T
authors.initials: T
authors.lastname: Duprez
authors.forename: M
authors.initials: M
authors.lastname: Lonneux
authors.forename: L
authors.initials: L
authors.lastname: Michaux
authors.forename: L
authors.initials: L
authors.lastname: Renard
authors.forename: C J M
authors.initials: CJ
authors.lastname: Sindic
authors.forename: F E
authors.initials: FE
authors.lastname: Lecouvet
mesh_terms: D000328:Adult; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D010025:Osteoradionecrosis / Q000209:etiology*; D011832:Radiation Injuries / Q000175:diagnosis*; D011878:Radiotherapy / Q000009:adverse effects*; D013118:Spinal Cord Diseases / Q000209:etiology*; D013997:Time Factors