Trichloroethylene induced testicular toxicity in rats exposed by inhalation.
Trichloroethylene (TCE) is an organic solvent used in dry cleaning, metal degreasing, thinner for paints and varnishes, anesthetic agent, and so forth. Human beings are appreciably exposed to TCE vapours by inhalation route. The present study has been undertaken to investigate whether TCE inhalation may also bring about testicular toxic effects. Our results indicate that inhalation of TCE by male rats for 12 and 24 weeks brings about significant reduction in absolute testicular weight, and alters marker testicular enzymes activity associated with spermatogenesis and germ cell maturation, along with marked histopathological changes showing depletion of germs cells and spermatogenic arrest.
Kumar
P
P
Inhalation Toxicology Division and Animal House, Industrial Toxicology Research Centre, Lucknow, India.
Prasad
A K
AK
Mani
U
U
Maji
B K
BK
Dutta
K K
KK
D000818:Animals; D001284:Atrophy / Q000473:pathology; D015415:Biomarkers; D019570:Inhalation Exposure; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013733:Testicular Diseases / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D013737:Testis / Q000201:enzymology / Q000473:pathology; D014241:Trichloroethylene / Q000008:administration & dosage / Q000633:toxicity*
D015415:Biomarkers; D014241:Trichloroethylene