Zinc-deficient rats are insensitive to glucoprivation caused by 2-deoxy-D-glucose.
Three-choice macronutrient intake studies indicate that zinc-deficient (Zn-) rats selectively decrease intake of carbohydrate. Because glucoprivic stimuli increase food intake and selection for carbohydrate, the ability of Zn- rats to respond to glucoprivation induced by 2-deoxy-D-glucose (2-DG) was tested. Rats were fed a Zn-adequate (Zn+) or Zn- diet. In part 1, rats were challenged with 0, 250, or 400 mg 2-DG/kg BW (i.p.) after zinc deficiency was established. In part 2, rats received saline or 2-DG while zinc deficiency was being induced and then after deficiency was established. Food intake was increased after injection of 2-DG to Zn+ rats; however, food intake was not higher after 2-DG administration to Zn- rats. A dose-response test for 2-DG further confirmed these results. In part 2, it was found that Zn- rats lose the response to 2-DG administration when zinc deficiency-induced anorexia begins, after 3 days of consuming a zinc-deficient diet. It appears that the ability to sense blood glucose concentrations may be impaired during zinc deficiency, and this impairment could be a part of the anorexia that develops during zinc deficiency in the rat.
Cole
A C
AC
Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana 61801, USA.
Shay
N F
NF
O'Brien
S
S
Beverly
J L
JL
D000818:Animals; D000855:Anorexia / Q000209:etiology; D001786:Blood Glucose / Q000378:metabolism*; D003847:Deoxyglucose / Q000008:administration & dosage / Q000494:pharmacology*; D004032:Diet; D004435:Eating / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015032:Zinc / Q000008:administration & dosage / Q000172:deficiency*
D001786:Blood Glucose; D003847:Deoxyglucose; D015032:Zinc