title: Chronic pain with beneficial response to electroconvulsive therapy and regional cerebral blood flow changes assessed by single photon emission computed tomography.
abstract: BACKGROUND
  Recent neuroimaging studies suggested that chronic neuropathic pain may be largely sustained by a complex neuronal network involving the thalamus. Although recent studies have demonstrated the efficacy of electroconvulsive therapy (ECT) in the treatment of a variety of types of chronic neuropathic pain, the effects of ECT on regional cerebral blood flow (rCBF) have not been studied.
  
  
  OBJECTIVE
  We present a 50-year-old female postsurgical chronic pain patient whose pain had failed to respond to standard pain treatment, but was resolved by ECT. To investigate the potential role of rCBF in ECT's analgesic effect, we measured significant changes in the rCBF in the thalamus before and after a course of bilateral ECT using technetium-99m ethyl cysteinate dimer (99mTc-ECD) single photon emission computed tomography (SPECT).
  
  
  RESULTS
  99mTc-ECD SPECT showed a significant bilateral decrease in the thalamus on the side of the pain, and this decreased rCBF in the thalamus increased after ECT.
  
  
  CONCLUSIONS
  The results from the SPECT suggest that ECT increases abnormally decreased thalamus activity in chronic neuropathic pain.
authors.affiliation: Department of Anesthesiology, Shiga University of Medical Science, Tukinowa, Seta, Otsu, Shiga 520-2192, Japan. sei@belle.shiga-med.ac.jp
authors.forename: Sei
authors.initials: S
authors.lastname: Fukui
authors.forename: Shino
authors.initials: S
authors.lastname: Shigemori
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yoshimura
authors.forename: Shuichi
authors.initials: S
authors.lastname: Nosaka
mesh_terms: D002560:Cerebrovascular Circulation; D002908:Chronic Disease; D004565:Electroconvulsive Therapy; D006801:Humans; D010146:Pain / Q000503:physiopathology; D059408:Pain Management; D015899:Tomography, Emission-Computed, Single-Photon