Dermatitis, glossitis, stomatitis, cheilitis, anemia and weight loss: a classic presentation of pancreatic glucagonoma.
Glucagonomas are rare tumors. They are predominantly located in the body or tail of the pancreas and display a constellation of signs and symptoms referred to as glucagonoma syndrome. The term necrolytic migratory erythema is used to characterize the distinctive rash associated with this syndrome. This report describes a classic presentation consisting of dermatitis, glossitis, stomatitis, angular cheilitis, anemia, and weight loss that was associated with the finding of a pancreatic mass and a markedly elevated plasma glucagon level. After pancreatic resection, the patient had complete resolution of the rash and normalization of plasma glucagon.
Povoski
Stephen P
SP
Division of Surgical Oncology, Department of Surgery, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Ohio State University, Columbus, USA.
Zaman
Syed A
SA
Ducatman
Barbara S
BS
McFadden
David W
DW
D000740:Anemia / Q000209:etiology; D003872:Dermatitis / Q000209:etiology; D005260:Female; D005928:Glossitis / Q000209:etiology; D005935:Glucagonoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D013280:Stomatitis / Q000209:etiology; D013577:Syndrome; D015431:Weight Loss