Paracetamol poisoning unmasking factor VII deficiency.
We report on an 18-year-old woman who took an impulsive overdose of paracetamol. The admission international normalized ratio (INR) was prolonged which resulted in her being transferred to a specialist hepatology unit. Her clinical condition and laboratory parameters did not correlate; this prompted investigation into her coagulation profile, which revealed a factor VII deficiency and explained the observed abnormalities of an elevated INR, normal partial thromboplastin time and normal liver function. There are no other reports of factor VII deficiency being identified as a result of paracetamol overdose.
Chilton
Andrew P
AP
Birmingham Liver Unit, Birmingham University Trust Hospitals, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK. chiltona@hotmail.com
Hussain
Tariq
T
Elias
Elwyn
E
D000082:Acetaminophen / Q000506:poisoning*; D000293:Adolescent; D062787:Drug Overdose; D005168:Factor VII Deficiency / Q000175:diagnosis*; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D010314:Partial Thromboplastin Time
D000082:Acetaminophen