title: A functional food product for the management of weight.
abstract: More than half of Americans have a body mass index of 25 kg/m2 or more, which classifies them as overweight or obese. Overweight or obesity is strongly associated with comorbidities such as type 2 diabetes mellitus, hypertension, heart disease, gall bladder disease, and sleep apnea. Clearly, this is a national health concern, and although about 30 to 40% of the obese claim that they are trying to lose weight or maintain weight after weight loss, current therapies appear to have little effect. None of the current popular diets are working, and there is room for innovation. With the advancing science of nutrition, several nutrients - low-glycemic-index carbohydrates, 5-hydroxytryptophan, green tea extract, and chromium - have been identified that may promote weight loss. The first two nutrients decrease appetite, green tea increases the 24-h energy expenditure, and chromium promotes the composition of the weight lost to be fat rather than lean tissue. These have been assembled in efficacious doses into a new functional food product and described in this review. The product is undergoing clinical testing; each component has already been shown to promote weight loss in clinical trials.
authors.affiliation: Functional Foods, Inc., Belmont, MA 02478, USA. staceyjbell@yahoo.com
authors.forename: Stacey J
authors.initials: SJ
authors.lastname: Bell
authors.forename: G Ken
authors.initials: GK
authors.lastname: Goodrick
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology; D019440:Anti-Obesity Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001066:Appetite / Q000187:drug effects*; D002857:Chromium / Q000494:pharmacology; D004040:Dietary Carbohydrates / Q000378:metabolism*; D004043:Dietary Fiber / Q000008:administration & dosage / Q000378:metabolism; D002149:Energy Intake / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D058870:Food, Organic; D006801:Humans; D009765:Obesity / Q000628:therapy*; D010848:Picolinic Acids / Q000494:pharmacology; D013662:Tea
chemical_list: D019440:Anti-Obesity Agents; D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D010848:Picolinic Acids; D013662:Tea; D002857:Chromium; D006916:5-Hydroxytryptophan; C030614:picolinic acid