Genetic variants of the receptors for thromboxane A2 and IL-4 in atopic dermatitis.
Thromboxane A2 (TXA2) is an arachidonate metabolite which is considered to relate to chronic inflammation in atopic diseases characterized by elevated immunoglobulin E productivity. The elevation of immunoglobulin E levels involves many molecules including interleukin-4 (IL-4) and interleukin-4 receptor alpha chain (IL-4R alpha). To assess whether genetic variants of TXA2 receptor, IL-4 and IL-4R alpha genes relate to the elevation of serum immunoglobulin E levels in patients with atopic dermatitis (AD), we conducted an association study of genetic polymorphisms of TXA2 receptor (795C/T), IL-4 (-589C/T), and IL-4R alpha (Ile50Val) in a Japanese population (n = 789). The TXA2 receptor 795TT genotype strongly related to AD with high serum immunoglobulin E concentrations. AD patients with both TXA2 receptor 795TT genotype and the IL-4R alpha Ile50/Ile50 genotype showed the greatest immunoglobulin E concentrations. These results suggest TXA2 receptor polymorphism strongly interacts with IL-4R alpha polymorphism as a major determinant of high serum immunoglobulin E levels in AD.
Tanaka
Keiko
K
Experimental Medicine Unit, University of Wales Swansea, Swansea SA2 8PP, United Kingdom. keikotanaka_2000@yahoo.com
Roberts
Mark H
MH
Yamamoto
Naoko
N
Sugiura
Hisashi
H
Uehara
Masami
M
Mao
Xiao-Quan
XQ
Shirakawa
Taro
T
Hopkin
Julian M
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003876:Dermatitis, Atopic / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D019948:Receptors, Interleukin-4 / Q000235:genetics* / Q000276:immunology; D017482:Receptors, Thromboxane / Q000235:genetics* / Q000276:immunology
D019948:Receptors, Interleukin-4; D017482:Receptors, Thromboxane; D007073:Immunoglobulin E