Thyrotropin and Prolactin Secretion During ECT: Implications for the Mechanism of ECT Action.
The effect of electroconvulsive therapy (ECT) on serum thyrotropin (TSH) and prolactin (PRL) was systematically investigated in two studies: a simulated ECT (SECT) versus real ECT controlled design, and one in which a more sensitive TSH assay was used. In addition to the expected PRL response, a small but consistent TSH increase was demonstrated, especially when the new TSH assay was used. The implications of these findings concerning the underlying ECT mechanisms mediating these effects are discussed and the involvement of thyrotropin-releasing hormone (TRH) and serotonin is stressed.
Papakostas
Yiannis
Y
Athens University Medical School Psychiatric Clinic, Eginition Hospital, Athens, Greece.
Markianos
Manolis
M
Papadimitriou
George
G
Stefanis
Costas
C