[Disturbances in biliary secretion during tissue hypoxia and attempts at their corrections].
In acute experiments on rats in vivo the stimulating effects of hydrophilic cholic acids (CA and UDCA) on the bilification and their inhibiting by rotenone have been shown. The secretion of CA and UDCA under rotenone have been determined to be activated. The mechanisms of the influence of the cholic acids on the secretory function of the hepatocytes have being discussed. It has been concluded that NADH-dehydrogenase link in the respiratory chain is not involved in the activating effects by CA and UDCA.
Hovorukha
T M
TM
A.A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kiev.
Nazarenko
A I
AI
Zhalilo
L I
LI
Fil'
H B
HB
Baban
V M
VM
Seredenko
M M
MM
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D015687:Cell Hypoxia; D002756:Cholagogues and Choleretics / Q000008:administration & dosage* / Q000494:pharmacology; D019826:Cholic Acid / Q000008:administration & dosage* / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009245:NADH Dehydrogenase / Q000037:antagonists & inhibitors; D051381:Rats; D012402:Rotenone / Q000008:administration & dosage / Q000494:pharmacology; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage* / Q000494:pharmacology
D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D012402:Rotenone; D014580:Ursodeoxycholic Acid; D009245:NADH Dehydrogenase; D019826:Cholic Acid
Porushennia protsesiv zhovchovydilennia pry tkanynniĭ hipoksiï ta sproby ïkh korektsiï.