title: The effect of respiratory tract infections on reported asthma symptoms.
abstract: BACKGROUND
  Wheezing and chest tightness is associated with respiratory tract infections. Thus the occurrence of respiratory tract infections may influence the prevalence of asthma.
  
  
  OBJECTIVE
  To assess the strength of relation between two main symptoms of asthma and the prevalence of respiratory tract infections in children with and without asthma.
  
  
  METHODS
  The study population was 3,796 children, four years of age, whose parents had answered a questionnaire on respiratory symptoms and asthma. The prevalence of wheezing and chest tightness in the last 12 months and four weeks was estimated according to the occurrence of respiratory tract infections during the corresponding time periods; 95% confidence intervals of the prevalence and the statistical significance of the differences in the prevalence by using chi-square test were calculated.
  
  
  RESULTS
  The prevalence of wheezing and chest tightness was higher in children who had experienced respiratory tract infections than in those who had not. The prevalence of wheezing was 17.5% among children who had experienced bronchitis and 3.0% among children whom had not (p<0.001). The prevalence of chest tightness in the last 12 months was 3.7% (95% CI 3.1-4.1) among children without asthma and 59.3% (95% CI 53.4-65.2) among children with asthma (p<0.001). The prevalence of wheezing and chest tightness increased with increasing number of different types of respiratory tract infections among children without asthma (p<0.001) and tended to be so among children with asthma.
  
  
  CONCLUSIONS
  These findings have implications for the interpretation of results from epidemiological studies using respiratory symptoms as a health-related outcome of asthma.
authors.affiliation: Department of Population Health Sciences, National Institute of Public Health, Oslo, Norway. wenche.nystad@folkehelsa.no
authors.forename: Wenche
authors.initials: W
authors.lastname: Nystad
authors.forename: Per
authors.initials: P
authors.lastname: Nafstad
authors.forename: Jouni J K
authors.initials: JJ
authors.lastname: Jaakkola
mesh_terms: D001249:Asthma / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D002675:Child, Preschool; D006801:Humans; D009664:Norway / Q000453:epidemiology; D011159:Population Surveillance; D015995:Prevalence; D012042:Registries; D012141:Respiratory Tract Infections / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D011795:Surveys and Questionnaires