title: Computed tomographic features of hepatocellular carcinoma predict long-term survival after hepatic resection.
abstract: OBJECTIVE
  To evaluate the potential of computed tomographic features of hepatocellular carcinoma as prognostic factors.
  
  
  METHODS
  Medical records for 112 patients who had undergone a partial hepatectomy for hepatocellular carcinoma were retrospectively analyzed. The largest hepatic tumour in each patient was classified by pre-operative computed tomographic features as lobular configurations with indentations showing an acute angle, or non-lobular configuration without such indentations.
  
  
  RESULTS
  Twenty-six tumours were lobular and 86 were non-lobular. The outcome after hepatectomy was significantly worse in patients with lobular tumours (cumulative 5-year survival rate of 19.9%) than with non-lobular ones (that of 75.2%) (P<0.001). Cox's proportional hazards model showed computed tomographic features (P=0.0025), cirrhosis (P=0.0033), and tumour size (P=0.0412) to be independent prognostic factors. A lobular configuration was associated with satellite nodules (P<0.001), portal vein invasion (P=0.021), and extrahepatic tumour relapse (P=0.006).
  
  
  CONCLUSIONS
  Computed tomographic features represent a strong prognostic factor in patients undergoing partial hepatectomy for hepatocellular carcinoma, and are likely to accurately reflect the tumour biology. Configuration, size of the hepatic tumour and presence of cirrhosis are the most important prognostic imaging findings in these patients.
authors.affiliation: Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Wakai
authors.forename: Y
authors.initials: Y
authors.lastname: Shirai
authors.forename: T
authors.initials: T
authors.lastname: Nomura
authors.forename: S
authors.initials: S
authors.lastname: Nagakura
authors.forename: K
authors.initials: K
authors.lastname: Hatakeyama
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000401:mortality; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008499:Medical Records; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed