Regulation of dynorphin gene expression by kappa-opioid agonist treatment.
The effects of K-opioid agonist treatment on prodynorphin mRNA expression in the rat brain were studied. Rats were treated with the selective kappa-opioid agonist U-69593 or vehicle for 5 days and prodynorphin mRNA was measured on day 8 (3 days after the last injection) or 22 (17 days after the last injection). On day 8 prodynorphin mRNA was increased in the hypothalamus and decreased in the striatum, frontal cortex, and hippocampus of rats treated with U-69593. On day 22, prodynorphin mRNA was increased in the hypothalamus, frontal cortex and striatum of U-69593 treated rats. These findings suggests that kappa-opioid receptor agonist treatment has long-term, continually changing effects on prodynorphin mRNA expression.
Collins
Stephanie
S
Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33136, USA.
D'Addario
Claudio
C
Romualdi
Patrizia
P
Candeletti
Sanzio
S
Izenwasser
Sari
S
D000818:Animals; D044482:Benzeneacetamides; D001921:Brain / Q000502:physiology*; D004745:Enkephalins / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects*; D008297:Male; D011498:Protein Precursors / Q000235:genetics* / Q000378:metabolism; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017473:Receptors, Opioid, kappa / Q000819:agonists*; D013997:Time Factors; D014018:Tissue Distribution
D044482:Benzeneacetamides; D004745:Enkephalins; D011498:Protein Precursors; D011759:Pyrrolidines; D017473:Receptors, Opioid, kappa; C033660:preproenkephalin; C045444:U 69593