title: The genus Bifidobacterium for cancer gene therapy.
abstract: A fundamental obstacle in cancer gene therapy is the specific targeting of therapy to solid tumor; as yet, no systemic delivery system exists. Bifidobacterium longum, a strain of domestic bacteria that is non-pathogenic and anaerobic, selectively localized to and proliferated in solid tumors after systemic application. We propose a novel approach to cancer gene therapy in which anaerobic bacteria of the genus B longum are used to achieve tumor-specific gene delivery and enzyme-prodrug therapy.
authors.affiliation: Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. minoru1@hsp.md.shinshu-u.ac.jp
authors.forename: Minoru
authors.initials: M
authors.lastname: Fujimori
authors.forename: Jun
authors.initials: J
authors.lastname: Amano
authors.forename: Shun'ichiro
authors.initials: S
authors.lastname: Taniguchi
mesh_terms: D000818:Animals; D001644:Bifidobacterium / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D005818:Genetic Engineering; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D011355:Prodrugs / Q000008:administration & dosage
chemical_list: D011355:Prodrugs