Oncologic implications of laparoscopic and open surgery.
Although instrumental manipulation and mechanical tumor cell spillage seem to play the major role in port-site metastases from laparoscopic cancer surgery, minimally invasive procedures are used more and more in the resection of malignancies. However, port-site metastases also have been reported after resection of colon cancer in International Union Against Cancer (UICC) stage I [2, 14]. Therefore, changes in the peritoneal environment during laparoscopy also might influence intra- and extraperitoneal tumor growth during laparoscopy and pneumoperitoneum. Different results of experimental studies presented at the Third International Conference for Laparoscopic Surgery are analyzed and discussed.
Jacobi
C A
CA
Surgical Department, University of Berlin, Charité, Schumannstar. 20 / 21, D-10098 Berlin, Germany.
Bonjer
H J
HJ
Puttick
M I
MI
O'Sullivan
R
R
Lee
S W
SW
Schwalbach
P
P
Tomita
H
H
Kim
Z G
ZG
Hewett
P
P
Wittich
P
P
Fleshman
J W
JW
Paraskeva
P
P
Gessman
T
T
Neuhaus
S J
SJ
Wildbrett
P
P
Reymond
M A
MA
Gutt
C
C
Whelan
R I
RI
D000818:Animals; D002245:Carbon Dioxide / Q000009:adverse effects; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects* / Q000379:methods; D008495:Medical Oncology; D023421:Models, Animal; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009366:Neoplasm Seeding; D010534:Peritoneal Neoplasms / Q000473:pathology; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects; D051381:Rats
D002245:Carbon Dioxide