[Apoptosis in myocardial ischemia and reperfusion].
Apoptosis initiated in cells of tissues maintaining homeostasis under the influence of growth factors and hormones has been recently described during the early stage of myocardial infarction in the reperfusion zone of the cardiac muscle. Although it has been proved that apoptosis of cardiomyocytes plays one of the key roles in progression of the reperfusion syndrome, molecular and cellular mechanisms of this phenomenon are not yet resolved. Prospects are discussed of a new trend in preventive treatment of ischemic and reperfusion-related affection of the myocardium relying upon blocking of apoptosis of cardiomyocytes.
Zalesskiĭ
V N
VN
Gavrilenko
T I
TI
Fil'chenkov
A A
AA
D000818:Animals; D017209:Apoptosis; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D017202:Myocardial Ischemia / Q000473:pathology* / Q000517:prevention & control; D015428:Myocardial Reperfusion Injury / Q000473:pathology* / Q000517:prevention & control; D009206:Myocardium / Q000473:pathology; D009626:Terminology as Topic
Apoptoz pri ishemii i reperfuzii miokarda.