The binding constants of the alpha(1)-foetoprotein of the rat embryo serum for oestrone and oestradiol-17beta have similar values, i.e. 1 x 10(8) M(-1) in average at 25 degrees. There is probably one binding site per mole of binding protein. The high alpha(1)-foetoprotein concentration in the rat embryo serum at 17-19 days of pregnancy explains the exceptionally high levels of fixation of the phenolsteroids by this serum.
Savu
L
L
Laboratoire de Biochimie médicale (Laboratoire Associé no. 87 du CNRS), U.E.R. des Saints-Pères, 45 rue des Saints-Pères, 75--6ème, Paris, France
Crepy
O
O
Guerin
M A.
MA
Nunez
E
E
Engelmann
F
F
Benassayag
C
C
Jayle
M F.
MF
Etude des constantes de liaison entre les oestrogenes et 1'alpha(1)-foetoproteine de rat.