title: Efficacy of moxidectin for the prevention of adult heartworm (Dirofilaria immitis) infection in dogs.
abstract: The authors report the efficacy of orally administered moxidectin for the prevention of canine heartworm infection in two endemic areas in northern Italy. Two trials were conducted on a total of 257 dogs, including 137 treated with moxidectin (minimum dose of 3 mcg/kg body weight), 85 with ivermectin (minimum dose 6.6 mcg/kg b.w.) and 35 untreated controls. Results of testing for microfilariae and circulating adult female antigens were negative for all treated dogs at the end of both trials. No adverse reactions to moxidectin were observed. In the study areas, prevalence values for Dirofilaria immitis infection calculated on the basis of the untreated controls and testing dogs which had no preventive treatment in the previous transmission season ranged 23-65%. This study confirms the efficacy and safety of moxidectin in the prevention of adult heartworm infection in dogs.
authors.affiliation: Dipartimento di Patologia Veterinaria, Igiene e Salute Pubblica Veterinaria, Università di Milano, Milano, Italy. claudio.genchi@unimi.it
authors.forename: C
authors.initials: C
authors.lastname: Genchi
authors.forename: G
authors.initials: G
authors.lastname: Poglayen
authors.forename: L H
authors.initials: LH
authors.lastname: Kramer
authors.forename: L
authors.initials: L
authors.lastname: Venco
authors.forename: A
authors.initials: A
authors.lastname: Agostini
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000947:Antigens, Helminth / Q000097:blood; D004183:Dirofilaria immitis / Q000187:drug effects* / Q000276:immunology; D004184:Dirofilariasis / Q000453:epidemiology / Q000517:prevention & control*; D004283:Dog Diseases / Q000453:epidemiology / Q000469:parasitology / Q000517:prevention & control*; D004285:Dogs; D005260:Female; D005369:Filaricides / Q000494:pharmacology / Q000627:therapeutic use*; D007558:Italy / Q000453:epidemiology; D007559:Ivermectin / Q000494:pharmacology / Q000627:therapeutic use; D018942:Macrolides; D008297:Male; D008842:Microfilariae / Q000302:isolation & purification; D015995:Prevalence; D012449:Safety
chemical_list: D000900:Anti-Bacterial Agents; D000947:Antigens, Helminth; D005369:Filaricides; D018942:Macrolides; D007559:Ivermectin; C027837:moxidectin