title: Subclinical central pontine myelinolysis following liver transplantation.
abstract: Central pontine myelinolysis (CPM) is a demyelinating disorder of unknown origin that almost exclusively affects the central portion of the basis pontis, and is one of the fatal neurological complications after liver transplantation. We describe two children with CPM detected incidentally after liver transplantation. To our knowledge, this is the first report of CPM diagnosed antemortem in children who had undergone liver transplantation. In our patients, there were no clinical manifestations associated with CPM. We conclude that, including silent cases such as our patients, CPM may be more prevalent than previously appreciated following liver transplantation.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. takeo819@kuhp.kyoto-u.ac.jp
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
authors.forename: Haruo
authors.initials: H
authors.lastname: Hattori
authors.forename: Masako
authors.initials: M
authors.lastname: Nagato
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kiuchi
authors.forename: Shinji
authors.initials: S
authors.lastname: Uemoto
authors.forename: Tatsutoshi
authors.initials: T
authors.lastname: Nakahata
authors.forename: Koichi
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000293:Adolescent; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007223:Infant; D016031:Liver Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D017590:Myelinolysis, Central Pontine / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D011149:Pons / Q000473:pathology; D012086:Reoperation