Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction.
Adaptor proteins, composed of two or more protein-protein interacting modules without enzymatic activity, regulate various cellular functions. Vinexin, CAP/ponsin, and ArgBP2 constitute a novel adaptor protein family. They have a novel conserved region homologous to the active peptide sorbin, as well as three SH3 (src homology 3) domains. A number of proteins binding to this adaptor family have been identified. There is accumulating evidence that this protein family regulates cell adhesion, cytoskeletal organization, and growth factor signaling. This review will summarize the structure and the function of proteins in this family.
Kioka
Noriyuki
N
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan. nkioka@kais.kyoto-u.ac.jp
Ueda
Kazumitsu
K
Amachi
Teruo
T
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism / Q000502:physiology*; D051275:Glucose Transporter Type 4; D006133:Growth Substances / Q000378:metabolism; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D009004:Monosaccharide Transport Proteins / Q000378:metabolism; D009124:Muscle Proteins / Q000737:chemistry / Q000378:metabolism*; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*; D016601:RNA-Binding Proteins; D015398:Signal Transduction / Q000502:physiology*; D018909:src Homology Domains
D048868:Adaptor Proteins, Signal Transducing; D051275:Glucose Transporter Type 4; D006133:Growth Substances; D018398:Homeodomain Proteins; D007328:Insulin; D008840:Microfilament Proteins; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; D011506:Proteins; D016601:RNA-Binding Proteins; C495692:SLC2A4 protein, human; C490755:SORBS2 protein, human; C486523:SORBS3 protein, human; C119201:ponsin