Resolution of epithelial ingrowth in a patient treated with 5-fluorouracil.
OBJECTIVE
To report the effect of 5-fluorouracil on the outcome of a single case of epithelial ingrowth secondary to a wound leak after a complicated penetrating keratoplasty.


METHODS
Case report.


METHODS
A 44-year-old man with extensive epithelial ingrowth after trauma and a penetrating keratoplasty received a fluid-gas exchange followed by two injections of 500 microg of 5-fluorouracil into the anterior chamber.


RESULTS
Two weeks after receiving the 5-fluorouracil injections, complete disappearance of the epithelial ingrowth from the anterior chamber occurred. No evidence of recurrence was detectable at 5 months.


CONCLUSIONS
Use of 5-fluorouracil is a potentially effective treatment of epithelial ingrowth, particularly in eyes with extensive involvement, in which the risks of traditional ablative therapeutic modalities are considerable.
Lai
Michael M
MM
Wilmer Ophthalmological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.
Haller
Julia A
JA
D000328:Adult; D000867:Anterior Chamber / Q000187:drug effects; D000963:Antimetabolites / Q000627:therapeutic use*; D003316:Corneal Diseases / Q000188:drug therapy* / Q000209:etiology; D004847:Epithelial Cells / Q000187:drug effects* / Q000473:pathology; D005131:Eye Injuries / Q000150:complications; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D007267:Injections; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy*; D012421:Rupture
D000963:Antimetabolites; D005472:Fluorouracil