[Effect of beta-blockers on the cardiac rhythm variability in patients with hypertension].
As many as 29 patients with arterial hypertension were examined. All patients were instituted a 3-week antihypertensive therapy with metoprolol. Against the background of intake of metoprolol, there occurs a rise in indices for variability of the heart's rhythm. Augmentation of total power of the spectrum due to metoprolol occurs largely because of enhancement of the parasympathetic activity which can be regarded as a positive effect on the sympathicopara-sympathetical control. In apparent enhancement of the parasympathetic nervous system against the background of ingestion of metoprolol the activity of the sympathetic component is not inhibited, the drug leading to redistribution of influences toward that portion of the autonomic nervous system which had been more inhibited before the intake of the drug.
Bil'chenko
A V
AV
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology; D018667:Tilt-Table Test
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D008790:Metoprolol
Vliianie beta-blokatorov na pokazateli variabel'nosti serdechnogo ritma u bol'nykh gipertonicheskoĭ bolezn'iu.