[Experimental study on treatment of chronic renal failure with yishen qudu capsule].
OBJECTIVE
To study the mechanism of action of Yishen Qudu capsule (YSQDC) in experimental rat model of chronic renal failure (CRF).


METHODS
Membranous nephropathy model was induced by cationized bovine serum albumin intravenous administration in rats for 7 weeks and developed to CRF. The model was then treated with YSQDC of large or small dose by gastrogavage for 5 weeks. Oxidated starch was used in the control group.


RESULTS
YSQDC could reduce proteinuria, serum creatinine, blood urea nitrogen, total cholesterol, triglyceride and serum circulating immune complex (P < 0.01 or P < 0.05), it also reduced the kidney coefficient, glomerular cells and tubular protein cast significantly (all P < 0.01). The strength of immune fluorescence weakened remarkably (P < 0.01). The pathological lesions improved significantly after treatment under light and electron-microscopic examination.


CONCLUSIONS
YSQDC could improve renal function significantly and inhibit the progression of CRF.
Wang
G
G
Postgraduate School of China Academy of TCM, Beijing 100700.
Li
C
C
Jin
L
L
D000818:Animals; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015433:Glomerulonephritis, Membranous / Q000150:complications; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D002214:Capsules; D004365:Drugs, Chinese Herbal