title: Change of guinea pig inner ear pressure by square wave middle ear cavity pressure variation.
abstract: The inner ear fluid pressure of guinea pigs was measured during square wave middle ear cavity pressure variation. Time constants were derived for the slopes of the inner ear pressure recovery curves after middle ear pressure change. A "single exponential" function did not fit well and therefore more complicated functions were used for this purpose. For middle ear pressure increasing from zero to a few centimetres of water, returning to zero again, decreasing from zero to minus a few centimetres of water and then returning to zero again, time constants for the inner ear pressure recovery curves were on average 15.0, 8.6, 2.5 and 2.5 s, respectively. The results could not be described using a linear model with constant window membrane compliance and cochlear aqueduct flow resistance. A possible explanation for the large difference in time constants for positive or negative middle ear pressure changes is a dependence on aqueduct flow resistance or round window membrane position.
authors.affiliation: Department of Otorhinolaryngology, University Hospital Groningen, The Netherlands. r.a.feijen@kno.azg.nl
authors.forename: R A
authors.initials: RA
authors.lastname: Feijen
authors.forename: J M
authors.initials: JM
authors.lastname: Segenhout
authors.forename: F W J
authors.initials: FW
authors.lastname: Albers
authors.forename: H P
authors.initials: HP
authors.lastname: Wit
mesh_terms: D000818:Animals; D003052:Cochlear Aqueduct / Q000502:physiology; D007758:Ear, Inner / Q000502:physiology*; D004432:Ear, Middle / Q000502:physiology*; D005260:Female; D006168:Guinea Pigs; D007761:Labyrinthine Fluids / Q000502:physiology; D011312:Pressure; D012405:Round Window, Ear / Q000502:physiology; D013995:Time