title: Combined chemotherapy and radiation therapy for head and neck malignancies: quality of life issues.
abstract: BACKGROUND
  The standard of care for locally advanced head and neck carcinoma usually has been surgery followed by radiation therapy. Patient survival using this approach has been reported to be poor. The disfiguration resulting from surgery and the long-term morbidity of postoperative radiation often results in considerable distress. Concurrent chemotherapy and radiation was introduced to improve outcome. Excellent local control and survival results often have been reported in Phase II and Phase III studies. The acute toxicity of combined chemotherapy and radiation is significant. However, organ preservation may improve quality of life. This review article summarizes the findings from published series of surgery, postoperative radiation, radiation therapy alone, and chemoradiation with regard to quality of life issues for patients with locally advanced head and neck carcinoma.
  
  
  METHODS
  A literature search was used to identify quality-of-life studies of postoperative radiation, radiation therapy alone, and chemoradiation in patients with locally advanced head and neck carcinoma. Factors affecting long-term quality-of-life issues in each treatment modality were identified, compared, and evaluated.
  
  
  RESULTS
  Speech disorder, dysphagia, pain, and depression were found to be the common side effects affecting quality of life regardless of the treatment modality. Xerostomia is the major complication affecting patients undergoing radiation or chemoradiation.
  
  
  CONCLUSIONS
  Acute side effects of combined chemotherapy and radiation therapy usually were found to resolve after treatment. Long-term morbidity is substantial because of xerostomia and severe dysphagia. However, preliminary studies suggest that because of organ preservation, patients may achieve a better quality of life after chemoradiation compared with the conventional use of surgery and postoperative radiation.
authors.affiliation: Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA. NamPhong.Nguyen@med.va.gov
authors.forename: Nam P
authors.initials: NP
authors.lastname: Nguyen
authors.forename: Sabah
authors.initials: S
authors.lastname: Sallah
authors.forename: Ulf
authors.initials: U
authors.lastname: Karlsson
authors.forename: John E
authors.initials: JE
authors.lastname: Antoine
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000188:drug therapy* / Q000523:psychology / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D003680:Deglutition Disorders / Q000209:etiology; D003863:Depression / Q000209:etiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000523:psychology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D010146:Pain / Q000209:etiology; D011788:Quality of Life; D013064:Speech Disorders / Q000209:etiology; D014987:Xerostomia / Q000209:etiology