title: Multiplicity of mechanisms of serotonin receptor signal transduction.
abstract: The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those subfamilies have been characterized by overlapping pharmacological properties, amino acid sequences, gene organization, and second messenger coupling pathways. Post-genomic modifications, such as alternative mRNA splicing or mRNA editing, creates at least 20 more G-protein-coupled 5-HT receptors, such that there are at least 30 distinct 5-HT receptors that signal through G-proteins. This review will focus on what is known about the signaling linkages of the G-protein-linked 5-HT receptors, and will highlight some fascinating new insights into 5-HT receptor signaling.
authors.affiliation: The Research Service of the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29401, USA. raymondj@musc.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Raymond
authors.forename: Y V
authors.initials: YV
authors.lastname: Mukhin
authors.forename: A
authors.initials: A
authors.lastname: Gelasco
authors.forename: J
authors.initials: J
authors.lastname: Turner
authors.forename: G
authors.initials: G
authors.lastname: Collinsworth
authors.forename: T W
authors.initials: TW
authors.lastname: Gettys
authors.forename: J S
authors.initials: JS
authors.lastname: Grewal
authors.forename: M N
authors.initials: MN
authors.lastname: Garnovskaya
mesh_terms: D000262:Adenylyl Cyclases / Q000096:biosynthesis / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D011494:Protein Kinases / Q000096:biosynthesis / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D010738:Type C Phospholipases / Q000096:biosynthesis / Q000494:pharmacology
chemical_list: D007473:Ion Channels; D011985:Receptors, Serotonin; D000242:Cyclic AMP; D011494:Protein Kinases; D010738:Type C Phospholipases; D000262:Adenylyl Cyclases