[Concentration of glutathione (GSH), ascorbic acid (Vit. C), and thiobarbiturate acid reacting components (MDA) in brain neoplasms].
The aim of the study was to evaluate the concentration of glutathione (GSH), ascorbic acid (Vit C), and thiobarbiturate acid reacting components (MDA) in brain neoplasms in specimens from normal brain tissue. The group of 72 individuals treated surgically for brain neoplasm in Department of Neurosurgery Medical Academy of Białystok (Poland) in the period from 1996 to 1999 was included into the study. The GSH concentration was estimated with GSH-400 method, ascorbic acid by the use of Kyaw method, and MDA by Salaris and Babs method. The statistical analysis revealed diminished concentration of GSH and Vit. C (p < 0.001), and analogous increase of MDA concentration (p < 0.001) in the investigated specimens compared to the mentioned above substances concentration in the specimens obtained from normal brain tissue.
Dudek
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Zakładu Chemii Analitycznej Akademii Medycznej w Białymstoku. wleb@amb.ac.bialystok.pl
Farbiszewski
R
R
Łebkowski
W J
WJ
Michno
T
T
Kozłowski
A
A
D000328:Adult; D001205:Ascorbic Acid / Q000032:analysis*; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000737:chemistry* / Q000473:pathology; D003124:Colorimetry; D005260:Female; D005978:Glutathione / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis*
D017392:Thiobarbituric Acid Reactive Substances; D005978:Glutathione; D001205:Ascorbic Acid
Stezenie glutationu (GSH), kwasu askorbowego (Vit. C) oraz substancji reagujacych z kwasem tiobarbiturowym (MDA) w nowotworach mózgu.