A fourth case of 8p11 myeloproliferative disorder transforming to B-lineage acute lymphoblastic leukaemia. A case report.
A 56-year-old male presented with inguinal lymphadenopathy and leucocytosis (WBC 98 x 10(9)/l). Bone marrow morphology showed myeloid hyperplasia, with eosinophilia. Cytogenetic analysis showed no evidence of the Philadelphia chromosome, and fluorescence in situ hybridisation studies for the BCR/ABL fusion were negative. All cells examined showed the t(8;13)(p11;q12) translocation. Six weeks after presentation, the disease progressed to an acute lymphoblastic leukaemia (ALL). The lymphoblasts were CD19/CD10 dual positive. Cytogenetic analysis again showed the t(8;13) translocation, with no additional abnormalities. There have been at least 14 reported cases of the t(8;13) myeloproliferative disorder to date, of which only 3 transformed to B-lineage ALL: our case is the 4th.
JabbarAl-Obaidi
M
M
Department of Haematology, Birmingham Heartlands Hospital, Birmingham, UK.
Rymes
N
N
White
P
P
Pomfret
M
M
Smith
H
H
Starczynski
J
J
Johnson
R
R
D001854:Bone Marrow Cells / Q000473:pathology; D002051:Burkitt Lymphoma / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002882:Chromosomes, Human, Pair 13; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic