Adrenomedullin and proadrenomedullin N-terminal 20 peptide in the normal prostate and in prostate carcinoma.
There is increasing evidence for the important role played by regulatory peptides in the physiology of the normal and neoplastic prostate. Adrenomedullin (AM) and pro-adrenomedullin N-terminal 20 peptide (PAMP) are recently discovered regulatory peptides widely expressed in the normal prostate and in prostate carcinoma. AM is produced in secretory, stroma, and endothelial cells and in neurons of the prostate ganglia. PAMP is only produced by neuroendocrine cells. The expression of AM mRNA is regulated by androgens in the rat prostate. The number of neuroendocrine cells expressing PAMP is increased in prostate carcinoma after androgen deprivation, which shows that this peptide could regulate androgen-independent prostate tumor growth. However, the roles of AM and PAMP in the normal prostate and in prostate carcinoma are yet to be elucidated.
Calvo
Alfonso
A
Department of Histology and Pathology, University of Navarra, Pamplona, Spain. calvoa@mail.nih.gov
Abasolo
Ibane
I
Jiménez
Nuria
N
Wang
Zhou
Z
Montuenga
Luis
L
D053607:Adrenomedullin; D000818:Animals; D002277:Carcinoma / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D011467:Prostate / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats
D010446:Peptide Fragments; D010455:Peptides; D011506:Proteins; D053607:Adrenomedullin