[Estimation and optimization of the use of standard arterial input function for split-dose administration of N-isopropyl-p[123I]iodoamphetamine].
Use of a standard arterial input function and calibrating it by a single blood sample or a continuous arterial blood sample has been researched for a repeat CBF assessment with split-dose administration of N-isopropyl-p[123I]iodoamphetamine (IMP).


METHODS
The study population consisted of 5 normal volunteers and 5 patients with cerebrovascular disease. IMP was injected twice (111 MBq/2 ml each) into the anti-cubital vein at a constant infusion speed for 1 min. The arterial input function was monitored during the study including a continuous measurement of radioactivity concentration of both the whole-blood and the octanol-soluble component (Real-Input Function, RIF). Standard input function was determined, and was calibrated either by a single blood sample or a continuous blood sample to estimate the Estimated-Input Function (EIF). Area-Under-the Curve (AUC) was then compared between RIF and EIF.


RESULTS
In case EIF was estimated with a single blood sample, the minimum error of estimated AUC was obtained when calibrated at 7 minutes after either the 1st or 2nd injections. Deviation of AUC for [0, 30] was +/- 6.6%, and +/- 5.0%, respectively. If calibrated with a continuous blood sample, the minimum error of AUC with the continuous blood sampling period of 10 min for [0, 30] and [30, 60] was +/- 5.3% and +/- 4.0%, respectively.


CONCLUSIONS
AUC of EIF with either a single or continuous blood sampling appeared to have reasonably small errors, suggesting the validity of the use of standardized input function in the split-dose IMP SPECT.
Kurisu
Rei
R
Department of Radiology, Sapporo Azabu Neurosurgical Hospital.
Ogura
Toshiyuki
T
Takikawa
Syugo
S
Saito
Hisatoshi
H
Nakazawa
Mayumi
M
Iida
Hidehiro
H
D000328:Adult; D000368:Aged; D001800:Blood Specimen Collection / Q000379:methods; D002138:Calibration / Q000592:standards; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000592:standards; D020367:Iofetamine / Q000008:administration & dosage* / Q000592:standards; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000592:standards; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods / Q000592:standards*
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D020367:Iofetamine