title: Antioxidant and cyclooxygenase activities of fatty acids found in food.
abstract: Several commercially available C-8 to C-24 saturated and unsaturated fatty acids (1-29) were assayed for cyclooxygenase-I (COX-I) and cyclooxygenase-II (COX-II) inhibitory and antioxidant activities. Among the saturated fatty acids tested at 60 microg mL(-1), there was an increase in antioxidant activity with increasing chain length from octanoic acid to myristic acid (C-8-C-14) and a decrease thereafter. All unsaturated fatty acids tested at 60 microg mL(-1) showed good antioxidant activity except for undecylenic acid (12), cis-5-dodecenoic acid (13), and nervonic acid (29). The highest inhibitory activities among the saturated fatty acids tested on cyclooxygenase enzymes COX-I and COX-II were observed for decanoic acid to lauric acid (3-5) at 100 microg mL(-1). Similarly, among the unsaturated fatty acids tested, the highest activities were observed for cis-8,11,14-eicosatrienoic acid (25) and cis-13,16-docosadienoic acid (27) at 100 microg mL(-1).
authors.affiliation: Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, Michigan 48824, USA.
authors.forename: Geneive E
authors.initials: GE
authors.lastname: Henry
authors.forename: Rafikali A
authors.initials: RA
authors.lastname: Momin
authors.forename: Muraleedharan G
authors.initials: MG
authors.lastname: Nair
authors.forename: David L
authors.initials: DL
authors.lastname: Dewitt
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D005504:Food Analysis; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D008081:Liposomes / Q000737:chemistry; D008297:Male; D008565:Membrane Proteins; D010084:Oxidation-Reduction; D011451:Prostaglandin-Endoperoxide Synthases; D051381:Rats; D012669:Seminal Vesicles / Q000201:enzymology; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D007527:Isoenzymes; D008081:Liposomes; D008565:Membrane Proteins; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; C496513:Ptgs1 protein, rat