Development of muscular blood pumps performed in a one-step operation.
Up to now, the employment of skeletal muscle ventricles (SMVs) has required a two-step operation, that is, first, the construction followed by a vascular delay and electrical conditioning, and second, the integration into circulation by a second operation. As shown previously, clenbuterol increased the power of electrically conditioned SMVs wrapped around a mock system. These clenbuterol-supported SMVs pumped successfully from construction to several months against a pressure of 60-70 mm Hg. Due to these successful former experiments, a muscular blood pump has been employed via a one-step procedure, trained within the circulation under the support of clenbuterol. It appeared to be hemodynamically relevant and is expected to become clinically practicable for the treatment of end-stage heart failure.
Guldner
Norbert W
NW
Clinic of Cardiac Surgery and Clinic of Anesthesiology, Medical University of Lübeck, Lübeck, Germany. guldner@medinf.mu-luebeck.de
Klapproth
Peter
P
Grossherr
Martin
M
Sievers
Hans-H
HH
D000818:Animals; D006041:Goats; D006333:Heart Failure / Q000601:surgery; D006353:Heart-Assist Devices; D006439:Hemodynamics; D008297:Male; D018482:Muscle, Skeletal / Q000601:surgery* / Q000637:transplantation