title: Primitive neuroectodermal tumors/medulloblastoma.
abstract: The therapy for medulloblastoma/primitive neuroectodermal tumors of the central nervous system is surgery, followed by combination chemo-radiotherapy. The radiation field is the entire craniospinal axis, which is only avoided when treating infants. The treatment is, therefore, lengthy and toxic. Less aggressive therapy is given to patients who clinically appear to have less evidence of disease. Intensive basic research has begun to identify genetic factors of the disease, but these remain far from clinical application.
authors.affiliation: Sirius Medicine, LLC, 584 West Douglas Road, Fort Collins, CO 80524, USA. mweil@frii.com
authors.forename: Michael D
authors.initials: MD
authors.lastname: Weil
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D002648:Child; D002869:Chromosome Aberrations; D004358:Drug Therapy / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D009367:Neoplasm Staging; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000379:methods; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D015996:Survival Rate; D016896:Treatment Outcome