Eccrine squamous syringometaplasia and syringomatous hyperplasia in association with linear scleroderma.
It is now well recognized that syringomatous hyperplasia with squamous syringometaplasia is a type of pseudoepitheliomatous hyperplasia responding to a variety of stimuli. We report a case of linear scleroderma with this process. Histopathology of the lesion showed numerous solid and cystic epithelial structures with squamous metaplasia within typical sclerodermatous skin lesions. Although the pathogenesis of the process remains unclear, dermal-derived growth factors in scleroderma and/or the mechanical effect of sclerosis could stimulate the proliferative response of eccrine epithelium. To the best of our knowledge, the association of syringomatous hyperplasia with eccrine squamous syringometaplasia and linear scleroderma has not been described previously.
Sakai
Hiroyuki
H
Department of Dermatology, Asahikawa Medical College, Japan. mc9@asahikawa-med.ac.jp
Satoh
Katsuhiko
K
Manabe
Akira
A
Nakane
Hiroshi
H
Ishida-Yamamoto
Akemi
A
Iizuka
Hajime
H
D002648:Child; D004439:Eccrine Glands / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D012594:Scleroderma, Localized / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology*; D013543:Sweat Gland Diseases / Q000150:complications* / Q000473:pathology