title: Outcome of patients with radiation enteritis treated with home parenteral nutrition.
abstract: OBJECTIVE
  Intestinal failure requiring either surgery or home parenteral nutrition (HPN) develops in approximately 5% of patients treated with radiation. The aim of the study was to determine survival, duration of HPN, and complications associated with HPN in patients with intestinal failure after radiation therapy.
  
  
  METHODS
  Fifty-four patients with radiation enteritis who received HPN were studied (39 women and 15 men with a mean age of 57.9 yr). Retrospective data were collected from the patients' medical records dated between 1975 and 1999. The probability of survival was calculated by the Kaplan-Meier method.
  
  
  RESULTS
  HPN was initiated a median of 20 months (range = 2-432) from the start of radiation therapy. The mean number of intestinal operations for radiation-related complications was 2.2/patient (range = 0-6). The causes of intestinal failure resulting from radiation therapy were intestinal obstruction (27 patients), short bowel (17), malabsorption (five), fistula (three), and dysmotility (two). The mean duration of HPN was 20.4 months (range = 2-108). At last follow-up, 37 patients (68%) were dead, most as a result of recurrent cancer. One patient died of catheter sepsis, and no other deaths were directly related to HPN. The overall estimated 5-yr probability of survival on HPN calculated by Kaplan-Meier analysis was 64%.
  
  
  CONCLUSIONS
  HPN is a reasonable treatment option in patients with intestinal failure as a result of radiation enteritis. Survival and complications associated with HPN in patients with radiation enteritis seem to be similar to those in other HPN-treated groups.
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32224, USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Scolapio
authors.forename: Andrzej
authors.initials: A
authors.lastname: Ukleja
authors.forename: Jan U
authors.initials: JU
authors.lastname: Burnes
authors.forename: Darlene G
authors.initials: DG
authors.lastname: Kelly
mesh_terms: D000328:Adult; D000368:Aged; D004751:Enteritis / Q000209:etiology* / Q000401:mortality / Q000628:therapy*; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D016331:Parenteral Nutrition, Home / Q000009:adverse effects*; D011832:Radiation Injuries / Q000150:complications* / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome