title: Lack of association between some risk factors and hepatitis B surface antigenaemia in children with sickle cell anaemia.
abstract: The risk factors for transmission of Hepatitis B virus (HBV) as well as the relationship between HBs Antigeneamia and some socio-cultural factors including socio-economic status of the families of the children, tribe, religion, rural or urban domicile and the number of persons per bedroom, were studied among 507 children with sickle cell anaemia (SCA) and 501 controls at the Jos University Teaching Hospital (JUTH). Twenty-three percent (22.7%) of the children with SCA were HBsAg positive compared with 19.6% among the control group. None of the risk factors studied, including blood transfusion, parenteral injections, intravenous infusions, hospitalization, ulcers, traditional uvulectomy, surgery, contact with case of known hepatitis, mass immunizations, circumcision, ear piercing and traditional scarifications was significantly associated with HBV infection in both children with SCA and control group and also between children with SCA compared with controls. There was also no association between HBs Antigenaemia and the number of blood transfusions, intravenous infusion or hospitalization in both children with SCA and controls. Similarly, there was no association between the socio-cultural factors studied and HBs Antigenaemia. The result of this study suggests that HBV infection is common in children in this environment and other factors yet to, be identified may play a very important role in the transmission of HBV infection. The high prevalence of HBsAg obtained in both children with SCA and controls, and the lack of identifiable association between the risk factos studied and HBsAntigenaemia suggest that these children may have equally been exposed earlier in life.
authors.affiliation: Department of Paediatrics, Jos University Teaching Hospital, Jos, Nigeria.
authors.forename: I A
authors.initials: IA
authors.lastname: Angyo
authors.forename: A M
authors.initials: AM
authors.lastname: Yakubu
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications* / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003469:Culture; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000276:immunology / Q000635:transmission*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D007223:Infant; D008297:Male; D009549:Nigeria; D012307:Risk Factors; D012959:Socioeconomic Factors
chemical_list: D006514:Hepatitis B Surface Antigens