De novo design, synthesis, and in vitro evaluation of inhibitors for prokaryotic tRNA-guanine transglycosylase: a dramatic sulfur effect on binding affinity.
Meyer
Emmanuel A
EA
Laboratorium für Organische Chemie, ETH-Hönggerberg, HCI, 8093 Zürich, Switzerland.
Brenk
Ruth
R
Castellano
Ronald K
RK
Furler
Maya
M
Klebe
Gerhard
G
Diederich
François
F
D018360:Crystallography, X-Ray; D015195:Drug Design; D004405:Dysentery, Bacillary / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D010430:Pentosyltransferases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D011487:Protein Conformation; D017355:Zymomonas / Q000201:enzymology
D004791:Enzyme Inhibitors; D010430:Pentosyltransferases; C020837:queuine tRNA-ribosyltransferase