[Analyses of genetic model of psoriasis vulgaris].
OBJECTIVE
To explore the possible genetic model of psoriasis vulgaris.


METHODS
The complex segregation analysis and heritability calculation were performed with the aid of Penrose method, Falconer regression method and SAGE-REGTL program.


RESULTS
It was found that in 1043 patients with psoriasis vulgaris, 305 patients (29.24%) have the family history of psoriasis, and 738 patients have not the family history. A ratio of s/q approached 1/(square root of q) with Penrose method, and the heritability values of psoriasis in the first-degree and second-degree relatives were 67.04%, 46.6% respectively. By complex segregation analysis, Mendelian, non-major-gene model and environment model were rejected for psoriasis.


CONCLUSIONS
The results suggest that psoriasis follows a pattern of polygenetic or multifactorial inheritance rather than single-gene inheritance.
Zhang
Xuejun
X
Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, Anhui, 230022 P. R. China. ayzxj@mail.hf.ah.cn
Wang
Hongyan
H
Chen
Shanyu
S
Wang
Fuxi
F
Liu
Taofeng
T
Wang
Zaixing
Z
Li
Ming
M
Yang
Sen
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D011565:Psoriasis / Q000235:genetics*