title: Implication of 2-18fluor-2-deoxyglucose positron emission tomography in the follow-up of Hürthle cell thyroid cancer.
abstract: The aim of this retrospective study was to investigate the value of positron emission tomography (PET) with 2-18fluor-2-deoxy-glucose (FDG) in the follow-up of Hürthle cell thyroid cancer (HTC), a rare variant of thyroid malignancies. FDG-PET studies were performed in 17 patients with HTC. In subgroup A (n = 13) PET was initiated because of an elevated thyroglobulin (Tg) level whereas in subgroup B (n = 4) the study was performed to evaluate suspect findings of morphologic imaging while Tg remained undetectable. Pathologically increased FDG uptake was found in all patients of subgroup A. In 10 studies, PET results were proven as true-positive either by surgery or by morphologic imaging. One study was false-positive. Final evaluation was not possible in two cases. In subgroup B, PET was true-negative in three and false-positive in one patient. For the detection of recurrent HTC by means of FDG-PET a meta-analysis including data of a multicenter study revealed an overall sensitivity of 92%, a specificity of 80%, a positive predictive value of 92%, and a negative predictive value of 80% while the accuracy was 89%. This study supports the efficiency of FDG-PET in the follow-up of HTC.
authors.affiliation: Department of Nuclear Medicine, Heinrich-Heine-University Hospital Düsseldorf, Germany. michail.plotkin@charite.de
authors.forename: Michail
authors.initials: M
authors.lastname: Plotkin
authors.forename: Hubertus
authors.initials: H
authors.lastname: Hautzel
authors.forename: Bernd Joachim
authors.initials: BJ
authors.lastname: Krause
authors.forename: Daniela
authors.initials: D
authors.lastname: Schmidt
authors.forename: Rolf
authors.initials: R
authors.lastname: Larisch
authors.forename: Felix Manuel
authors.initials: FM
authors.lastname: Mottaghy
authors.forename: Anne-Rose
authors.initials: AR
authors.lastname: Boemer
authors.forename: Hans
authors.initials: H
authors.lastname: Herzog
authors.forename: Henning
authors.initials: H
authors.lastname: Vosberg
authors.forename: Hans-Wilhelm
authors.initials: HW
authors.lastname: Müller-Gärtner
mesh_terms: D018249:Adenoma, Oxyphilic / Q000000981:diagnostic imaging*; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes; D008297:Male; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D013954:Thyroglobulin / Q000097:blood; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D013954:Thyroglobulin