title: New triterpenoidal alkaloids from Buxus sempervirens.
abstract: Phytochemical studies on the ethanolic extract of the roots of Buxus sempervirens of Turkish origin have resulted in the isolation of two new triterpenoidal alkaloids, (+)-16a, 31-diacetylbuxadine (1), (-)-Nb-demethylcyclomikuranine (2) along with three known natural products, (-)-cyclomikuranine (3), (-)-cyclobuxophylline-K (4) and (+)-buxaquamarine (5) isolated for the first time from this species of genus Buxus. The structures of these new natural products were established on the basis of extensive spectroscopic studies. Compound 1 exhibited antibacterial activity against human pathogenic bacteria and weak phytotoxic activity against Lemna minor Linn.
authors.affiliation: Department of Chemistry, The University of Winnipeg, Manitoba, Canada. chemistry@c-h.uwinnipeg.ca
authors.forename: Athar
authors.initials: A
authors.lastname: Ata
authors.forename: Samina
authors.initials: S
authors.lastname: Naz
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.lastname: Atta-ur-Rahman
authors.forename: Bilge
authors.initials: B
authors.lastname: Sener
authors.forename: Songul
authors.initials: S
authors.lastname: Turkoz
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014421:Turkey
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D014315:Triterpenes