title: [Langerhans cell histiocytois of the thyroid: a rare disease not to be ignored].
abstract: Thyroid involvement by Langerhans cell histiocytosis is rare. We report the case of a ten-year old boy who presented with a 5 cm goitre. He was treated for diabetes insipidus 14 months before. Thyroid isotopic scan showed hypoactivity of right lobe and revealed a cold left nodule. The patient was treated by right lobo-isthmectomy with adjuvant corticotherapy and chemotherapy (vinblastine). He is well with 12 months follow-up. Microscopic analysis demonstrated a diffuse infiltrate of thyroid parenchyma by sheets of CD1a positive Langerhans cells associated with lymphocyte foci. This case is remarkable by the abundance of Langerhans cells and scarcity of eosinophils. The diagnosis of thyroid langerhans cell histiocytosis should not be ignored in both children and adult patients.
authors.affiliation: Service d'anatomie et cytologie pathologiques, Institut Salah Azaiez, 1006 Bab Saadoun Tunis, Tunisie, France. karima.mrad@rns.tn
authors.forename: Karima
authors.initials: K
authors.lastname: Mrad
authors.forename: Imene
authors.initials: I
authors.lastname: Abbes
authors.forename: Hassen
authors.initials: H
authors.lastname: Ben Salah
authors.forename: Mohamed-Hedi
authors.initials: MH
authors.lastname: Ben Amor
authors.forename: Samia
authors.initials: S
authors.lastname: Sassi
authors.forename: Khaled
authors.initials: K
authors.lastname: Ben Romdhane
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D018949:Antigens, CD1 / Q000032:analysis; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D004804:Eosinophils / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology; D008297:Male; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013965:Thyroidectomy; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D018949:Antigens, CD1; D000970:Antineoplastic Agents; D014747:Vinblastine
vernacular_title: L'histiocytose langerhansienne de la thyroïde: une localisation rare à ne pas méconnaître.