title: Postnatal growth, neurobehavioral and neurophysiologic changes of prenatal low-dose beta-radiation from tritiated water in mice.
abstract: Pregnant adult C57BL/6J mice were randomly assigned to four groups: one sham and three irradiated groups that were exposed to -irradiation from tritiated water (HTO) by a single intraperitoneal injection on Day 12.5 of gestation. The offspring received cumulative doses of 0.036, 0.071, and 0.213 Gy, respectively. The litters were observed for postnatal growth (body weight, brain weight), the development of four physiologic milestones (pinna detachment, eye opening, testes decent, vaginal opening), the acquisition age of several reflexes (cliff avoidance, air righting) and sensory functions (auditory startle, thermal reflex), movement and coordination functions and activity (pivoting, foot splay, continuous corridor activity), learning and memory performance (shock avoidance, conditioning reflex), and the density of CA1-CA4 hippocampal pyramidal neurons. Modest but significant dose-dependent neuronal death and functional impairment were seen in both 0.071 and 0.213 Gy groups. In conclusion, even prenatal low-dose beta-radiation may impair murine central nervous system (CNS) development suggesting the potential importance of minimizing environmental exposure during human pregnancy.
authors.affiliation: Department of Environmental and Occupational Health, Room 307, Graduate School of Public Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA. wegst10@pitt.edu
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Gao
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Lu
authors.forename: Jin-Chan
authors.initials: JC
authors.lastname: Dong
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiang-Yan
authors.initials: XY
authors.lastname: Zhou
authors.forename: Larry W
authors.initials: LW
authors.lastname: Jenkins
authors.forename: C Edward
authors.initials: CE
authors.lastname: Dixon
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001362:Avoidance Learning / Q000528:radiation effects; D001522:Behavior, Animal / Q000528:radiation effects*; D001610:Beta Particles; D001835:Body Weight / Q000528:radiation effects*; D001921:Brain / Q000254:growth & development* / Q000473:pathology / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000528:radiation effects; D009929:Organ Size / Q000528:radiation effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014316:Tritium
chemical_list: D014316:Tritium