title: Defining the dynamics of self-assembled Fas-receptor activation.
abstract: Fas-Fas-ligand, the most well investigated apoptotic signaling system, plays a pivotal role in several human diseases. Its signaling through multiple pathways; multiple, complex regulatory points; and recently described tendency to undergo ligand-independent self-assembly warrant a comprehensive understanding of its physiologically well controlled function. In this review, we attempt to develop such a perspective on the regulation of Fas signaling. The multistep Fas regulation model presented here should be helpful in devising effective interventions for conditions resulting from the dysregulation of Fas.
authors.affiliation: Rush Cancer Institute, Rush-Presbyterian St Luke's Medical Center, 2242 West Harrison Street, Suite 108, Chicago, IL 60612-3515, USA. smundle@rush.edu
authors.forename: Suneel D
authors.initials: SD
authors.lastname: Mundle
authors.forename: Azra
authors.initials: A
authors.lastname: Raza
mesh_terms: D000818:Animals; D017209:Apoptosis; D016207:Cytokines / Q000378:metabolism; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008954:Models, Biological; D015398:Signal Transduction; D019014:fas Receptor / Q000378:metabolism*
chemical_list: D016207:Cytokines; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor