title: Memory-based comparison process not attenuated by haloperidol: a combined MEG and EEG study.
abstract: Auditory P50 and N100 responses reflect preattentive processing, whereas subsequent mismatch negativity (MMN) response indexes memory-based comparison process. Divergent ERP responses have been found in schizophrenia and in Parkinson's disease (PD), which have abnormalities in cerebral dopamine activity. We used simultaneously magnetoencephalography and electroencephalography to investigate, whether a single dose of haloperidol, a dopamine D2-receptor antagonist, modulates preattentive auditory processing using a randomized, double-blind, placebo-controlled crossover design. Our results showed that haloperidol did not alter MMN to frequency and duration changes, whereas the magnetic MMN to frequency change was significantly accelerated. The amplitude and latency changes of the electric and magnetic P50 and N100 were insignificant. Our results indicate that memory-based sound comparison and preceding cortical processing underlying stimulus detection are not attenuated by haloperidol, whereas haloperidol appears to accelerate preattentive sound comparison.
authors.affiliation: Department of Neurology, Medical Engineering Centre, Helsinki University Central Hospital, Finland.
authors.forename: Eero
authors.initials: E
authors.lastname: Pekkone
authors.forename: Jyrki
authors.initials: J
authors.lastname: Hirvonen
authors.forename: Jyrki
authors.initials: J
authors.lastname: Ahveninen
authors.forename: Seppo
authors.initials: S
authors.lastname: Kähkönen
authors.forename: Seppo
authors.initials: S
authors.lastname: Kaakkola
authors.forename: Juha
authors.initials: J
authors.lastname: Huttunen
authors.forename: Iiro P
authors.initials: IP
authors.lastname: Jääskeläinen
mesh_terms: D000328:Adult; D001306:Auditory Pathways / Q000187:drug effects* / Q000502:physiology*; D018592:Cross-Over Studies; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology*; D011930:Reaction Time / Q000187:drug effects
chemical_list: D018492:Dopamine Antagonists; D006220:Haloperidol