Long-term follow-up of patients with nonparalytic poliomyelitis.
OBJECTIVE
To examine patients with previous nonparalytic poliomyelitis in search of muscle atrophy, weakness, and other late symptoms of poliomyelitis.


METHODS
A mailed questionnaire followed up with neurologic and neurophysiologic examinations of respondents who reported symptoms possibly related to the late sequelae of polio.


METHODS
Neurology department at a university hospital.


METHODS
Thirty-nine of 47 patients diagnosed with nonparalytic poliomyelitis and hospitalized at a Norwegian hospital between 1950 and 1954, during the Norwegian polio epidemic.


METHODS
Not applicable.


METHODS
Electromyography to determine function of the anterior tibialis, vastus lateralis, and biceps brachii muscles; nerve conduction studies of the sural, peroneal, and tibial nerves; motor and sensory nerve conduction velocity, and compound muscle and sensory nerve action potentials, and distal latencies.


RESULTS
Twenty-five of 47 patients (53.2%) reported symptoms possibly related to the late sequelae of poliomyelitis. Eight of 20 examined symptomatic patients had normal neurologic and neurophysiologic findings, whereas 9 others had other medical conditions that could explain the symptoms. Three patients (6.7%) had neurologic and neurophysiologic findings and development of symptoms consistent with motoneuron damage.


CONCLUSIONS
Some nonparalytic patients may have subclinical acute motoneuron damage with subsequent development and manifestation of motor weakness and neuromuscular symptoms many years later. These symptoms should be considered a differential diagnosis in patients who have a history of nonparalytic poliomyelitis.
Rekand
Tiina
T
Department of Neurology, Unit of Clinical Neurophysiology, Haukeland University Hospital, N-5021 Bergen, Norway. Tiina.Rekand@haukeland.no
Karlsen
Bjørn
B
Langeland
Nina
N
Aarli
Johan A
JA
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004185:Disability Evaluation; D004196:Disease Outbreaks; D004576:Electromyography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008582:Meningitis, Aseptic / Q000175:diagnosis / Q000503:physiopathology / Q000534:rehabilitation; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D018908:Muscle Weakness / Q000175:diagnosis / Q000503:physiopathology / Q000534:rehabilitation; D009431:Neural Conduction / Q000502:physiology; D009460:Neurologic Examination; D011051:Poliomyelitis / Q000175:diagnosis* / Q000503:physiopathology / Q000534:rehabilitation; D011984:Sensory Receptor Cells / Q000503:physiopathology