A novel antibiotic CJ-17,572 from a fungus, Pezicula sp.
A new antibiotic, CJ-17,572 (I) was isolated from the fermentation broth of a fungus Pezicula sp. CL11877. The structure of I was determined to be a new equisetin derivative by spectroscopic analyses. The compound inhibits the growth of multi-drug resistant Staphylococcus aureus and Enterococcusfaecalis with IC50s of 10 and 20 microg/ml, respectively.
Sugie
Yutaka
Y
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. Yutaka.Sugie@japan.pfizer.com
Dekker
Koen A
KA
Inagaki
Taisuke
T
Kim
Yoon-Jeong
YJ
Sakakibara
Tatsuo
T
Sakemi
Shinichi
S
Sugiura
Akemi
A
Brennan
Lori
L
Duignan
Joan
J
Sutcliffe
Joyce A
JA
Kojima
Yasuhiro
Y
D000107:Acetylation; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D011760:Pyrrolidinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; C451491:CJ 17572; D011760:Pyrrolidinones; D013764:Tetrahydronaphthalenes