title: Response to treatment and disease progression linked to CD4+ T cell surface CC chemokine receptor 5 density in human immunodeficiency virus type 1 vertical infection.
abstract: The factors governing interindividual variability in disease progression among children vertically infected with human immunodeficiency virus type 1 (HIV-1) remain unclear. Because it has recently been shown in infected adults that the density of CC chemokine receptor 5 (CCR5) molecules at the surface of nonactivated (human leukocyte antigen [HLA]-DR(-)) CD4+ T cells correlates with disease progression, the same correlation was sought in children. HLA-DR(-)CD4+ T cell surface CCR5 density was constant over time and correlated with the bioclinical stage and with the CD4 cell slope observed before antiretroviral treatment. In addition, CCR5 density was negatively correlated with the intensity of the decrease in viremia during antiretroviral therapy and was positively correlated with CD4 cell slope since birth. These results are compatible with the hypothesis that CCR5 density is a key factor governing disease progression in pediatric HIV-1 infection and, thereby, an indicator of prognosis. Moreover, they suggest that therapies aimed at reducing CCR5 accessibility should slow down HIV disease evolution in children.
authors.affiliation: Département de Pédiatrie, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
authors.forename: Alain
authors.initials: A
authors.lastname: Gervaix
authors.forename: Joelle
authors.initials: J
authors.lastname: Nicolas
authors.forename: Pierre
authors.initials: P
authors.lastname: Portales
authors.forename: Klara
authors.initials: K
authors.lastname: Posfay-Barbe
authors.forename: Claire-Anne
authors.initials: CA
authors.lastname: Wyler
authors.forename: Michel
authors.initials: M
authors.lastname: Segondy
authors.forename: Odile
authors.initials: O
authors.lastname: Avinens
authors.forename: Claire-Anne
authors.initials: CA
authors.lastname: Siegrist
authors.forename: Jacques
authors.initials: J
authors.lastname: Clot
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Eliaou
authors.forename: Jacques
authors.initials: J
authors.lastname: Astruc
authors.forename: Pierre
authors.initials: P
authors.lastname: Corbeau
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000635:transmission; D000293:Adolescent; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015497:HIV-1; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D019713:Receptors, CCR5 / Q000032:analysis*
chemical_list: D019713:Receptors, CCR5