title: The molecular basis of Streptococcus equi infection and disease.
abstract: Streptococcus equi is the aetiological agent of strangles, one of the most prevalent diseases of the horse. The animal suffering and economic burden associated with this disease necessitate effective treatment. Current antibiotic therapy is often ineffective and thus recent attention has focused on vaccine development. A systematic understanding of S. equi virulence, leading to the identification of targets to which protective immunity can be directed, is a prerequisite of the development of such a vaccine. Here, the virulence factors of S. equi are reviewed.
authors.affiliation: Department of Biomedical Sciences, University of Bradford, West Yorkshire, BD7 1DP, UK. d.harrington@bradford.ac.uk
authors.forename: Dean J
authors.initials: DJ
authors.lastname: Harrington
authors.forename: Iain C
authors.initials: IC
authors.lastname: Sutcliffe
authors.forename: Neil
authors.initials: N
authors.lastname: Chanter
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006734:Horse Diseases / Q000382:microbiology*; D006736:Horses / Q000382:microbiology*; D013290:Streptococcal Infections / Q000382:microbiology* / Q000662:veterinary; D022541:Streptococcal Vaccines / Q000737:chemistry / Q000276:immunology; D018502:Streptococcus equi / Q000201:enzymology / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D022541:Streptococcal Vaccines