SWORDS: a statistical tool for analysing large DNA sequences.
In this article, we present some simple yet effective statistical techniques for analysing and comparing large DNA sequences. These techniques are based on frequency distributions of DNA words in a large sequence, and have been packaged into a software called SWORDS. Using sequences available in public domain databases housed in the Internet, we demonstrate how SWORDS can be conveniently used by molecular biologists and geneticists to unmask biologically important features hidden in large sequences and assess their statistical significance.
Chaudhuri
Probal
P
Theoretical Statistics and Mathematics Unit, Indian Statistical Institute, 203 BT Road, Kolkata 700 108, India. probal@isical.ac.in
Das
Sandip
S
D000818:Animals; D005075:Biological Evolution; D004272:DNA, Mitochondrial / Q000145:classification / Q000235:genetics*; D003627:Data Interpretation, Statistical; D030561:Databases, Nucleic Acid; D006801:Humans; D020407:Internet; D010802:Phylogeny; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software
D004272:DNA, Mitochondrial