[Regulatory effect of Erbao granules on brain-gut peptide in juvenile animal model of anorexia].
OBJECTIVE
To study the regulatory effect of Erbao granules (EBG) on central and peripheral brain-gut peptide in juvenile animal model of anorexia.


METHODS
Juvenile rat model of anorexia was established by imitating the major cause of infantile anorexia and treated with EBG. The cholocystokinin-octapeptide (CCK-8) and beta-endorphin (beta-EP) concentration in hypothalamus, antrum pyloricum and peripheral blood were examined by radioimmunoassay.


RESULTS
CCK-8 concentration in hypothalamus and plasma in the model rats increased (P < 0.05), while blood beta-EP concentration decreased (P < 0.05). After EBG treatment, the CCK-8 concentration normalized and beta-EP increased significantly.


CONCLUSIONS
EBG could reduce the central and peripheral CCK-8 and increase beta-EP secretion significantly in the juvenile anorexia model.
Zhang
Y
Y
Xijing Hospital, Fourth Military Medical University, Xi'an 710032.
Du
Y
Y
Wang
S
S
D000818:Animals; D000855:Anorexia / Q000378:metabolism*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012844:Sincalide / Q000378:metabolism; D001615:beta-Endorphin / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D001615:beta-Endorphin; D012844:Sincalide