Increased plasma HB-EGF associated with obesity and coronary artery disease.
The mechanism by which the obese subjects are more associated with vascular disease remains unclear. We reported that the adipose tissues produce and secrete many bioactive molecules, conceptualized as adipocytokines. Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF), produced locally by vascular macrophages and smooth muscle cells, has been suggested to induce the migration and proliferation of vascular smooth muscle cells. The current study reveals that (1) HB-EGF mRNA is abundantly expressed in human adipose tissue, (2) HB-EGF mRNA increases in the fat tissues of obese mice, (3) plasma HB-EGF levels increase in parallel with fat accumulation in human, and (4) the subjects with coronary artery disease have higher plasma HB-EGF levels, associated with fat accumulation. These results suggest that increased plasma HB-EGF derived from the accumulated fat contributes to the higher incidence of vascular disease in obesity, proposing HB-EGF as an adipocytokine directly linking adipovascular axis.
Matsumoto
Satoru
S
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, B5, Osaka University, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.
Kishida
Ken
K
Shimomura
Iichiro
I
Maeda
Norikazu
N
Nagaretani
Hiroyuki
H
Matsuda
Morihiro
M
Nishizawa
Hitoshi
H
Kihara
Shinji
S
Funahashi
Tohru
T
Matsuzawa
Yuji
Y
Yamada
A
A
Yamashita
S
S
Tamura
S
S
Kawata
S
S
D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000818:Animals; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology; D004815:Epidermal Growth Factor / Q000097:blood* / Q000235:genetics; D066257:Heparin-binding EGF-like Growth Factor; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice; D008820:Mice, Obese; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D012313:RNA / Q000378:metabolism; D013223:Statistics as Topic; D014018:Tissue Distribution
C587883:HBEGF protein, human; C587884:Hbegf protein, mouse; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D004815:Epidermal Growth Factor; D012313:RNA