[The role of reactive oxygen species as signal molecules in tissue metabolism in oxidative stress].
This review deals with literature data on the functioning of the reactive oxygen species (ROS) as second messengers. ROS induce various biological processes such as stimulation of protein phosphorylation, Ca(2+)-signaling, phospholipid hydrolysis and transcription factor activation. Physiological significance of the role of biological oxidants in the regulation of signal transduction and the mechanisms of the adaptation of organism to extremital conditions are discussed. Oxidative stress is a common step for the development of many diseases characterized by the intensive ROS generation.
Dubinina
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Psychoneurological Bekhterev Institute Russia, 193019, St. Petersburg, 3, Bekhterev Str.
D000222:Adaptation, Physiological; D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D004194:Disease; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology*; D010766:Phosphorylation; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
D017382:Reactive Oxygen Species; D014157:Transcription Factors
Rol' aktivnykh form kisloroda v kachestve signal'nykh molekul v metabolizme tkaneĭ pri sostoianiiakh okislitel'nogo stressa.