[Lipid peroxidation in the cyst fluid of craniopharyngiomas].
Comparing of the craniopharyngiomas cyst fluid, collected during the surgery, with blood plasma revealed significantly enhanced lipid peroxidation and lactate accumulation in tumour cysts contents. These processes were usually more prominent in endosuprasellar than in suprasellar craniopharyngiomas. The maximum of free radical formation in conjunction with the lowest level of malondialdehyde (MDA) was observed in primary tumours with relatively high proliferation rate. Controversial parameters ratio characterised the recurrent craniopharyngiomas, and in cyst fluids of the primary tumours with low proliferation rate the medium parameter's values were observed. Thus, the estimation of free radical formation level and MDA concentration in cyst fluid of craniopharyngioma seems to be prognostic for the tumour recurrence.
Aref'eva
I A
IA
Burdenko Neurosurgical Institute, Russian Academy of Medical Sciences, 4 Tverskaya-Yamskaya str., 16, 125047 Moscow, Russia. iarefyeva@nsi.ru
Semenova
Zh B
ZhB
Korshunov
A G
AG
Zubaĭraev
M S
MS
Krasnova
T S
TS
Gorelyshev
S K
SK
Promyslov
M Sh
MSh
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000737:chemistry*; D020420:Cyst Fluid / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D006801:Humans; D007223:Infant; D015227:Lipid Peroxidation; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local
D005609:Free Radicals
Perekisnoe okislenie lipidov v kistoznoĭ zhidkosti kraniofaringiom.