[Experimental study of protective effect of qingkailing on glutamate induced neurotoxic damage of brain].
OBJECTIVE
To observe the effect of Qingkailing (QKL) on glutamate induced damage of brain, in order to seek for effective drugs for antagonizing neurotoxicity of glutamate.


METHODS
Number and morphology metrology of neuron in cerebral cortex and hippocampus were detected by using MIAS-300 image analysing instrument, electron microscope and immunohistochemical methods.


RESULTS
QKL could allevate the glutamate induced accumulation of water and sodium in the brain tissue, relief the damage of cerebral cells and reduce the percentage of c-fos positive cell in brain.


CONCLUSIONS
QKL could protect brain damage induced by glutamate, which might be related to inhibition of QKL on glutamate caused enhancement of c-fos gene expression.
Yue
S
S
Xiangya Hospital, Hunan Medical University, Changsha (410008).
Zeng
Q
Q
Zhou
J
J
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D018698:Glutamic Acid; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D018698:Glutamic Acid