Mechanisms of apoptosis in central nervous system tumors: application to theory.
Apoptosis is a key concept for the successful therapy of brain tumors. This review focuses on the mechanisms of apoptosis occurring spontaneously in malignant gliomas, discusses the different methods employed to assess apoptosis in vivo and in vitro, and considers the value of quantifying apoptosis in surgical biopsies for diagnosis and prognosis. Further, novel strategies to induce apoptosis in human malignant glioma cells are reviewed, including experimental therapy with death ligands, methods for sensitizing glioma cells to the induction of apoptosis, p53 gene transfer, and approaches to target the expression of therapeutic genes selectively to tumor cells.
Steinbach
Joachim P
JP
Laboratory of Molecular Neuro-Oncology, Department of Neurology, University of Tübingen, Medical School, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany.
Weller
Michael
M
D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001932:Brain Neoplasms / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D016543:Central Nervous System Neoplasms / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D053222:Fas Ligand Protein; D015316:Genetic Therapy / Q000379:methods / Q000639:trends; D005910:Glioma / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008562:Membrane Glycoproteins / Q000819:agonists / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D016159:Tumor Suppressor Protein p53