Paracetamol disposition in renal allograft recipients.
OBJECTIVE
To evaluate the disposition of paracetamol in renal allograft recipients.


METHODS
Eight fasting renal allograft recipients were given 1 g soluble paracetamol orally.


RESULTS
Paracetamol was absorbed rapidly, and the mean plasma half-life from 2 h to 8 h was 2.6 +/- 0.5 h. After that, disappearance of paracetamol from the plasma was slower. Both the glucuronide and sulphate conjugates of paracetamol had slow elimination half-lives of 15.1 +/- 8.8 h and 26.2 +/- 14.6 h, and there were residual amounts of both conjugates in the plasma at 24 h. The renal clearances of both conjugates were low (21 +/- 14.2 ml/min and 32.4 +/- 31.4 ml/min) and there was a significant negative correlation between total amount of paracetamol recovered in the urine in 24 h and serum creatinine (r = -0.89, P<0.01).


CONCLUSIONS
Paracetamol disposition is abnormal in renal allograft recipients and seems to relate to abnormal renal function in these patients.
Martin
U
U
Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom. U.Martin@bham.ac.uk
Temple
R M
RM
Venkat-Raman
G
G
Prescott
L F
LF
D000082:Acetaminophen / Q000493:pharmacokinetics*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics*; D005260:Female; D020719:Glucuronides / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000378:metabolism; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
D018712:Analgesics, Non-Narcotic; D020719:Glucuronides; D000082:Acetaminophen