title: Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes.
abstract: Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer's patch lymphocytes in wild-type mice were beta7 and beta1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than beta7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.
authors.affiliation: Department of Microbiology, University of Pennsylvania, Philadelphia, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Czarneski
authors.forename: Paula
authors.initials: P
authors.lastname: Berguer
authors.forename: Pedro
authors.initials: P
authors.lastname: Bekinschtein
authors.forename: David C
authors.initials: DC
authors.lastname: Kim
authors.forename: Paul
authors.initials: P
authors.lastname: Hakimpour
authors.forename: Norbert
authors.initials: N
authors.lastname: Wagner
authors.forename: Irene
authors.initials: I
authors.lastname: Nepomnaschy
authors.forename: Isabel
authors.initials: I
authors.lastname: Piazzon
authors.forename: Susan R
authors.initials: SR
authors.lastname: Ross
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000956:Antigens, Viral / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000821:virology; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules; D002465:Cell Movement; D016207:Cytokines / Q000502:physiology; D005260:Female; D007136:Immunoglobulins / Q000502:physiology; D039641:Integrin beta Chains; D016023:Integrins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D007413:Intestinal Mucosa / Q000276:immunology / Q000473:pathology / Q000821:virology; D019041:L-Selectin / Q000235:genetics / Q000502:physiology*; D007774:Lactation; D008211:Lymphocyte Cooperation; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000821:virology; D008221:Lymphoid Tissue / Q000276:immunology / Q000473:pathology; D008321:Mammary Glands, Animal / Q000276:immunology / Q000473:pathology; D008324:Mammary Tumor Virus, Mouse / Q000502:physiology*; D051379:Mice; D008809:Mice, Inbred C3H; D018345:Mice, Knockout; D008892:Milk / Q000821:virology; D009077:Mucins / Q000502:physiology; D009088:Mucoproteins / Q000502:physiology; D010581:Peyer's Patches / Q000276:immunology / Q000821:virology; D012192:Retroviridae Infections / Q000276:immunology*; D018089:Superantigens / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000821:virology; D014412:Tumor Virus Infections / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D015820:Cadherins; D015815:Cell Adhesion Molecules; D016207:Cytokines; D007136:Immunoglobulins; D039641:Integrin beta Chains; D016023:Integrins; C489082:Madcam1 protein, mouse; D009077:Mucins; D009088:Mucoproteins; D018089:Superantigens; C071777:integrin alpha4beta7; C070709:integrin alphaEbeta7; C091368:integrin beta7; D019041:L-Selectin; C075185:sulfated glycoprotein p50