Effects of extract from Angelica keiskei and its component, cynaroside, on the hepatic bromobenzene-metabolizing enzyme system in rats.
The effects of Angelica keiskei Koidz. on hepatic lipid peroxide and the activities of free radical generating and scavenging enzymes were investigated in bromobenzene-induced hepatic lipid peroxidation in rats. The level of lipid peroxide elevated by bromobenzene was significantly reduced by the methanol extract from the aerial parts of A. keiskei and its component, cynaroside. Epoxide hydrolase activity was decreased significantly by the treatment of bromobenzene. However, the enzyme activity was restored in the liver of rats given the methanol extract and cynaroside. The results suggest that the reduction of bromobenzene-induced hepatic lipid peroxidation by the extract of A. keiskei and cynaroside under our experimental conditions is thought to be through enhancing the activity of epoxide hydrolase, an enzyme removing bromobenzene epoxide.
Park
Jong Cheol
JC
Department of Oriental Medicine Resources, Sunchon National University, Sunchon, Jonnam 540-742, Republic of Korea.
Park
Ju Gwon
JG
Kim
Hyun Joo
HJ
Hur
Jong Moon
JM
Lee
Jong Ho
JH
Sung
Nak Ju
NJ
Chung
Shin Kyo
SK
Choi
Jong Won
JW
D029969:Angelica; D000818:Animals; D001969:Bromobenzenes; D005419:Flavonoids / Q000494:pharmacology*; D005960:Glucosides / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D047311:Luteolin; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001969:Bromobenzenes; D005419:Flavonoids; D005960:Glucosides; D010936:Plant Extracts; C066408:luteolin-7-glucoside; C032036:bromobenzene; D047311:Luteolin