title: GM-CSF at relatively high topic concentrations can significantly enhance the healing of surgically induced chronic wounds after radiotherapy.
abstract: Combinations of radiotherapy and surgery are often used in local cancer treatments. Preoperative radiotherapy may delay wound healing after surgery. Chronic wounds are debilitating conditions that require frequent medical attention. Two patients suffering from chronic and slowly healing wounds post-surgery and preoperative radiotherapy are described. A significant acceleration of the healing by local injections with GM-CSF was demonstrated.
authors.affiliation: Department of General Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
authors.forename: J O
authors.initials: JO
authors.lastname: Fernberg
authors.forename: O
authors.initials: O
authors.lastname: Brosjö
authors.forename: S
authors.initials: S
authors.lastname: Friesland
authors.forename: G
authors.initials: G
authors.lastname: Masucci
mesh_terms: D000368:Aged; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011832:Radiation Injuries / Q000188:drug therapy* / Q000276:immunology; D012509:Sarcoma / Q000532:radiotherapy / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000532:radiotherapy / Q000601:surgery; D013529:Surgical Wound Dehiscence / Q000188:drug therapy* / Q000276:immunology; D014945:Wound Healing
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor