[Effects of alcohol and metabolite acetaldehyde on the proliferation of astroglial cells of fetal brain].
To explore the mechanism of the retardation and abnormality of nerve system development induced by drinking alcohol during pregnancy, 3H-TdR incorporation was used to study the proliferation of astroglial cells of fetal brain induced by alcohol and its metabolite acetaldehyde in vitro. The results showed that alcohol and acetaldehyde obviously restrain the proliferation of astrocytes. The effect of restrain induced by acetaldehyde is stronger than that by alcohol. Nerve system development retardation and abnormality resulted from alcohol is likely to be the restrain of proliferation induced by alcohol and its metabolite acetaldehyde.
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School of Public Health, West China University of Medical Sciences, Chengdu 610041, China.
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D000079:Acetaldehyde / Q000633:toxicity*; D000818:Animals; D001253:Astrocytes / Q000187:drug effects*; D001921:Brain / Q000166:cytology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005333:Fetus; D011247:Pregnancy; D051381:Rats
D000431:Ethanol; D000079:Acetaldehyde