Prion disease: close encounters of the cellular kind.
Co-culture of prion-infected cells with uninfected target cells has recently been found to lead to rapid and efficient transmission of infectivity to the target cells by a process that is dependent on direct cell contact.
Hooper
Nigel M
NM
School of Biochemistry and Molecular Biology, University of Leeds, LS2 9JT, Leeds, UK. n.m.hooper@leeds.ac.uk
D000818:Animals; D018920:Coculture Techniques; D006801:Humans; D018621:PrPC Proteins / Q000378:metabolism*; D018620:PrPSc Proteins / Q000378:metabolism*; D017096:Prion Diseases / Q000209:etiology / Q000378:metabolism* / Q000635:transmission
D018621:PrPC Proteins; D018620:PrPSc Proteins