title: Soluble selectin levels in patients with lung cancer.
abstract: Increased expression of selectins has been found on endothelial cells of venules and capillaries in the tumor stroma of non-small cell lung cancer, suggesting their functional role in the process of chemotaxis for tumor cells. The present study was aimed at analyzing the role of both soluble (s)P-selectin and sE-selectin levels in association with clinico-pathological variables in 116 patients with lung cancer, 38 patients with benign diseases and 59 healthy donors. The results obtained showed that sP-selectin and sE-selectin levels were higher in patients with lung cancer compared to normal donors (p<0.02 and p<0.005, respectively). No differences were observed among patients with various benign diseases for both selectins. Increased levels of sP-selectin and sE-selectin were significantly associated with squamous lung cancer at late stages (p<0.05), but not adenocarcinoma. Both sP- and sE-selectin were independently related to the stage of squamous lung cancer by stepwise regression analysis (p<0.02 and p<0.03, respectively), while only sE-selectin was independently related to the presence of distant metastasis in the same histotype (p<0.02). These results suggest that measurement of plasma soluble selectins might represent a useful laboratory parameter in the management of patients with squamous lung cancer.
authors.affiliation: Clinical Oncology Section, Department of Surgery, Tor Vergata University, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Roselli
authors.forename: T C
authors.initials: TC
authors.lastname: Mineo
authors.forename: F
authors.initials: F
authors.lastname: Martini
authors.forename: S
authors.initials: S
authors.lastname: Mariotti
authors.forename: V
authors.initials: V
authors.lastname: Ambrogi
authors.forename: A
authors.initials: A
authors.lastname: Spila
authors.forename: R
authors.initials: R
authors.lastname: D'Alessandro
authors.forename: S
authors.initials: S
authors.lastname: Basili
authors.forename: F
authors.initials: F
authors.lastname: Guadagni
authors.forename: P
authors.initials: P
authors.lastname: Ferroni
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D019040:E-Selectin / Q000096:biosynthesis*; D006801:Humans; D007118:Immunoassay; D008175:Lung Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D019007:P-Selectin / Q000096:biosynthesis*
chemical_list: D019040:E-Selectin; D019007:P-Selectin