Prolonged childhood Cushing's syndrome secondary to intralesional triamcinolone acetonide.
Intralesional corticosteroids have been used in the treatment of hypertrophic keloid scars for over 40 years. The few complications documented have mostly been local skin changes, viz depigmentation and cutaneous atrophy. Cushing's syndrome following intralesional injection is rare and usually self-limiting following cessation of therapy. This report describes a 9-year-old girl who developed Cushing's syndrome 2-3 weeks after a single treatment with 40 mg triamcinolone acetonide injected into keloids. Features of Cushing's syndrome and a suppressed hypothalamic-pituitary axis were present up to 9 months later. Three years after glucocorticoid injections, features of Cushing's syndrome had largely disappeared. Dosages of intralesional steroids normally recommended for adults are inappropriate for children.
Teelucksingh
S
S
Department of Medicine, Faculty of Medical Sciences, University of The West Indies, Trinidad, West Indies. smylz@tstt.net.tt
Balkaran
B
B
Ganeshmoorthi
A
A
Arthur
P
P
D002648:Child; D003480:Cushing Syndrome / Q000139:chemically induced*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D015552:Injections, Intralesional; D007627:Keloid / Q000188:drug therapy; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000009:adverse effects*
D005938:Glucocorticoids; D014222:Triamcinolone Acetonide