Segregation analysis of blood pressure and body mass index in a rural US community.
To assess evidence for a gene with large effect on systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI), we conducted segregation analyses on 261 nuclear families collected from a rural Caucasian community in Michigan. The families were ascertained through a hypertensive proband. Each phenotype was adjusted for significant covariate effects (e.g., gender and age). We used class D regressive models to conduct the segregation analyses. Our analysis results support the segregation of a major gene for BMI, but not for SBP or DBP. A recessive locus effect provided the best explanation for BMI where approximately 43% of the variance of BMI was due to this gene.
Nath
Swapan K
SK
Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, USA.
Chakravarti
Aravinda
A
Chen
Chien-Hsiun
CH
Cooper
Richard
R
Weder
Alan
A
Schork
Nicholas J
NJ
D000328:Adult; D001794:Blood Pressure / Q000235:genetics*; D015992:Body Mass Index; D016009:Chi-Square Distribution; D005260:Female; D005828:Genetics, Population; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D009679:Nuclear Family; D009765:Obesity / Q000235:genetics*; D010641:Phenotype; D012044:Regression Analysis; D012424:Rural Population; D014481:United States / Q000453:epidemiology; D044465:White People