title: The characteristics of side-effects of bromperidol in schizophrenic patients.
abstract: The characteristics of the side-effects of bromperidol was investigated in 33 acutely exacerbated schizophrenic patients. The most frequently observed side-effects were extrapyramidal symptoms. Acute dystonia developed in 10 of 33 patients, and the mean age was significantly lower (P < 0.05) in patients with dystonia (27.3 +/- 6.2 years) than that in patients without dystonia (41.5 +/- 12.9 years). Plasma drug concentrations were not associated with side-effects. These findings suggest that acute dystonia is affected by age factor, and that daily dosage or monitoring of drug concentration is unlikely to be a useful marker for the prediction of side-effects during bromperidol treatment.
authors.affiliation: Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan. yasufuru@cc.hirosaki-u.ac.jp
authors.forename: Norio
authors.initials: N
authors.lastname: Yasui-Furukori
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kondo
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ishida
authors.forename: Osamu
authors.initials: O
authors.lastname: Tanaka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mihara
authors.forename: Sunao
authors.initials: S
authors.lastname: Kaneko
authors.forename: Koichi
authors.initials: K
authors.lastname: Otani
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D004421:Dystonia / Q000139:chemically induced; D005260:Female; D006220:Haloperidol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D018476:Hypokinesia / Q000139:chemically induced; D008297:Male; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D014202:Tremor / Q000139:chemically induced
chemical_list: D014150:Antipsychotic Agents; D006220:Haloperidol; C006820:bromperidol