Preliminary assessment of selected methacrylic acid--acrylic acid copolymers as factors buffering triethanolamine interacting with artificial skin sebum.
To allow cleaning of sebum ducts for acne prophylaxis the authors suggest use of triethanolamine buffered with anionic polymers of acrylic and methacrylic acid. In these preliminary researches addition of Eudragit L-100, Eudragit L-100-55 or Eudragit S-100 implicates decrease of pH of 1.49% triethahnolamine solution from 10.06 even to 7.20. Triethanolamine penetrates into the artificial skin sebum, gains hydrophylic properties, and reacted sebum increase in volume allowing mechanical remove of lipid bed. The highest triethanolamine penetration and the highest volume increase were observed after application of Eudragit S-100 complexes. Eudragit L-100 and L-100-55 proved milder action. These complexes may be applied for further examinations on acne prevention.
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Department of Pharmaceutical Technology, Wroclaw Medical University.
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D000180:Acrylic Resins / Q000737:chemistry*; D002021:Buffers; D004983:Ethanolamines / Q000493:pharmacokinetics*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008954:Models, Biological; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012629:Sebum / Q000737:chemistry*; D017768:Skin, Artificial
D000180:Acrylic Resins; D002021:Buffers; D004983:Ethanolamines; D011109:Polymethacrylic Acids; C006903:carbopol 940; C009546:triethanolamine