Morphometric analysis of the cerebellar cortex capillaries in the course of experimental valproate encephalopathy and after chronic exposure to sodium valproate using transmission electron microscopy.
Morphometric analysis of the cerebellar cortex capillary cross-section area performed in experimental valproate encephalopathy using transmission electron microscopy showed that prolongation of VPA application resulted in more enhanced lumen narrowing manifested in gradual reduction in the mean value of the coefficient examined. After 6, 9 and 12 months of experiment this value was statistically different from that obtained in control subgroups, being respectively lower by approximately 22%, 48% and 65%. One month after terminating of chronic administration this value was close to the one found after 12 months of the study. Three months after the drug withdrawal the coefficient was higher by approximately 44% compared to the one after 12 months, which seemed to indicate an increase in capillary lumen patency. The morphometric analysis of the cerebellar cortex capillary cross-section area performed in the present study objectifies the results of qualitative ultrastructural investigations concerning the microcirculation of this CNS structure.
Sobaniec-Lotowska
M
M
Department of Pathological Anatomy, Medical Academy, Białystok, Poland.
Sobaniec
W
W
Augustynowicz
A
A
D000818:Animals; D000927:Anticonvulsants / Q000633:toxicity*; D001927:Brain Diseases / Q000139:chemically induced / Q000473:pathology*; D002196:Capillaries / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D002525:Cerebellar Cortex / Q000098:blood supply* / Q000473:pathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000633:toxicity*
D000927:Anticonvulsants; D014635:Valproic Acid