Association of serum antioxidant capacity with coronary artery disease in middle-aged men.
The possible involvement of oxidative damage in the progression of atherosclerosis has been suggested. There is some evidence that antioxidant therapy may be beneficial for the prevention of coronary heart disease. In this study, we investigated the relationship between coronary artery disease (CAD) and serum antioxidative status by measuring the total antioxidant status (TAS). Other relevant antioxidants, such as retinol, alpha, gamma-tocopherol, ascorbic acid, alpha, beta-carotenoids, erythrocyte glutathione peroxidase (GSH-Px) and oxidative products, were also determined in 31 male CAD patients with angiographically defined CAD and 66 male controls, aged 40-70 years, in a case-control study. The TAS levels, ratio and the concentrations of retinol, albumin, total protein and HDL cholesterol were significantly lower in the CAD patients than in the controls (p<0.01), and alpha-tocopherol and alpha/gamma-tocopherol were significantly higher in the CAD patients than in the controls. The TAS level correlated positively with gamma-GTP, GPT, GOT and uric acid (p<0.01). A multiple regression analysis in the CAD patients revealed that the TAS levels correlated most negatively with the number of diseased vessels. The concentrations of carotenoids and GSH-Px, as well as the alpha/gamma-tocopherol ratio were also significantly associated. Although conditional logistic regression analysis suggested low levels of HDL-cholesterol to be a significant coronary risk factor (OR=5.1, 95% CI=1.09-24.3), the TAS level showed no significant independent contribution to CAD. This study demonstrated an association of antioxidant parameters with the atherosclerosis progression, however, it did not confirm antioxidants as an independent risk factor for CAD event.
Nojiri
S
S
Tama Branch, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Daida
H
H
Mokuno
H
H
Iwama
Y
Y
Mae
K
K
Ushio
F
F
Ueki
T
T
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D001205:Ascorbic Acid / Q000097:blood; D002338:Carotenoids / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood*; D003327:Coronary Disease / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008875:Middle Aged; D018384:Oxidative Stress; D012044:Regression Analysis; D014801:Vitamin A / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood; D024504:gamma-Tocopherol / Q000097:blood
D000975:Antioxidants; D014801:Vitamin A; D002338:Carotenoids; D024504:gamma-Tocopherol; D005979:Glutathione Peroxidase; D024502:alpha-Tocopherol; D001205:Ascorbic Acid