title: [Antibiotic resistance and community-acquired infections].
abstract: The selective pressure of extended broad-spectrum antibiotic administration is leading to a progressively growing selection of common gram-positive and gram-negative organisms which show unpredictable in vitro antimicrobial susceptibility levels to current first-line therapeutic choices. This phenomenon is examined from an epidemiological, microbiological, therapeutical, and pharmacoeconomic point of view, focusing our attention on the most common community-acquired infectious diseases interesting upper and lower airways, genito-urinary and gastrointestinal tract, skin and soft tissues. A broad spectrum of variables is responsible for this ever changing scenario, whose solution cannot be entrusted to the development of new compounds, but it first relies on a rational and judicious administration of existing molecules, and an expanded medical and patient interaction aimed at avoiding overprescription of antimicrobial agents.
authors.affiliation: Dipartimento di Medicina Clinica Specialistica e Sperimentale, Alma Mater Studiorum Università di Bologna, Policlinico S. Orsola-Malpighi, Bologna. manfredi@.med.unibo.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Manfredi
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects*; D002648:Child; D017714:Community-Acquired Infections / Q000188:drug therapy*; D011307:Drug Prescriptions; D004352:Drug Resistance, Microbial; D005260:Female; D005759:Gastroenteritis / Q000188:drug therapy; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011472:Prostatitis / Q000188:drug therapy; D012141:Respiratory Tract Infections / Q000188:drug therapy; D012749:Sexually Transmitted Diseases / Q000188:drug therapy; D012874:Skin Diseases, Infectious / Q000188:drug therapy; D018461:Soft Tissue Infections / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Antibiotico-resistenza ed infezioni comunitarie.