[Malignant pleural mesothelioma. Present data and perspectives for treatment].
METHODS
With regard to the efficacy of mono-chemotherapy and according to the literature, no cytotoxic substance, apart from methrotrexate at high doses, leads to a response rate of more than 20%. With regard to cyrotoxic associations, the published results show slightly betterresponse rates.
Interleukine 2 as well as various interferons have been tested alone or in association with chemotherapy. Fairly encouraging response rates have been reported. However, the possibility of severe adverse events must be taken into account.
The interest of prophylactic parietal radiation following invasive thoracic treatment has been demonstrated. Palliative use of radiotherapy is possible for pain, and more rarely for decompression. With curative aim, the results of isolated radiotherapy are disappointing.


METHODS
Palliative surgery is aimed at reducing the tumour and pleural symphysis. Curative surgery consists in wide extrapleural pneumonectomy, permitting total resection of the visceral pleura, or decortication pleurectomy leaving the lung in place. Mean survival of patients having undergone surgery is of 10 to 17 months with rates between 10 and 30% at 2 years ASSOCIATED THERAPY: For the first time, despite high morbidity rates, associated therapy has led to prolonged survival, whereas isolated therapy has not. This is the case with an association of radical surgery, radiotherapy and adjuvant chemotherapy.


CONCLUSIONS
In the treatment of malignant pleural mesothelioma, genetic, anti-proliferative and immune therapy, that attempt to use the immune system of the patient to obtain an anti-tumour cytotoxic reaction, appear promising.
Bard
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Institut Gustave-Roussy, Département de Médecine, 39, rue Camille Desmoulins, F94805 Villejuif.
Ruffié
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D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D007167:Immunotherapy; D008654:Mesothelioma / Q000628:therapy*; D008727:Methotrexate / Q000627:therapeutic use; D010166:Palliative Care; D010997:Pleural Neoplasms / Q000628:therapy*; D011379:Prognosis; D011878:Radiotherapy / Q000639:trends
D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate
Le mésothéliome pleural malin. Données actuelles et perspectives pour le traitement.