Erythroleukemia: a comparison between the previous FAB approach and the WHO classification.
Erythroleukemia is, within FAB classification, a proliferation of erythroblasts superior to 50% and of myeloblasts superior to 30%. The new WHO classification abolishes the frontier between RAEB-t with 20% and leukemia with 30% of blasts. AML6 variant is a new entity characterized by the proliferation of immature erythroblasts and the absence of non-erythroid blast cells. We analyzed 16 erythroleukemia, 5 RAEB-t and 2 AML6 variants to clarify their relationship. We suggest on survival, karyotype and cytologic characteristics that secondary erythroleukemia are the same entity as RAEB-t, confirming the WHO classification and that amongst de novo erythroleukemia, there is 'AML6 variant' with pure erythroid lineage proliferation.
Park
Sophie
S
Service d'hématologie, Hôpital Cochin, 27 rue du Faubourg St-Jacques, 75014 Paris, France. parksophie@yahoo.com
Picard
Françoise
F
Azgui
Zahia
Z
Viguie
Franck
F
Merlat
Annabelle
A
Guesnu
Martine
M
Leblond
Véronique
V
Dreyfus
François
F
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000145:classification* / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D014944:World Health Organization