An autopsy case of POEMS syndrome with a high level of IL-6 and VEGF in the serum and ascitic fluid.
A 45-year-old woman was hospitalized because of systemic edema and peripheral nerve impairment. The patient had complications of organomegaly, endocrinopathy, and monoclonal gammmopathy, and was diagnosed with POEMS syndrome based on these characteristic signs and symptoms. Interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) levels in the serum and ascitic fluid were high. Many of the patient's symptoms were ameliorated, and IL-6 and VEGF levels in the serum and ascitic fluid decreased slightly during chemotherapy, but she died of respiratory failure. Autopsy revealed severe systemic edema and macroscopic hemorrhage in many organs, but VEGF and IL-6 producing cells were not found.
Minamitani
Shin
S
Department of Hepatology, Graduate School of Medicine Osaka City University, Osaka.
Ohfuji
Satoko
S
Nishiguchi
Shuhei
S
Shiomi
Susumu
S
Ogami
Masayuki
M
Matsuo
Toshihiko
T
Ohsawa
Masahiko
M
Ohta
Kensuke
K
Hino
Masayuki
M
D001202:Ascitic Fluid / Q000737:chemistry*; D001344:Autopsy; D016228:Endothelial Growth Factors / Q000032:analysis*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis*; D015850:Interleukin-6 / Q000032:analysis*; D008222:Lymphokines / Q000032:analysis*; D008875:Middle Aged; D016878:POEMS Syndrome / Q000378:metabolism* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors