Improved method for the quality assurance of [C-11]choline.
[C-11]choline is a very promising radiomarker for the diagnosis of various human tumors using Positron Emission Tomography (PET). The existing quality control process for [C-11]choline is complicated and combines two HPLC methods with limited separation and sensitivity which prevent the accurate determination of the specific activity. We have developed a new efficient single HPLC method for the detection of choline chloride and dimethylaminoethanol with high resolution and sensitivity using cation-exchange chromatography.
Mishani
E
E
Hebrew University, Hadassah Hospital, Department of Medical Biophysics and Nuclear Medicine, Il-91120, Jerusalem, Israel. mishani@md2.huji.ac.il
Ben-David
I
I
Rozen
Y
Y
D002794:Choline / Q000737:chemistry* / Q000592:standards; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003642:Deanol / Q000737:chemistry; D011786:Quality Control; D019275:Radiopharmaceuticals / Q000737:chemistry* / Q000592:standards; D012015:Reference Standards; D012996:Solutions
D019275:Radiopharmaceuticals; D012996:Solutions; D003642:Deanol; D002794:Choline