Two cases of adult T-cell leukaemia/lymphoma with oesophageal involvement.
We describe two cases of adult T-cell leukaemia/lymphoma (ATLL) with oesophageal involvement. The first case, a 51-year-old Japanese woman with an acute subtype of ATLL, had an irregular ulcerative lesion in the distal oesophagus. The second case, a 76-year-old Japanese man with a lymphoma subtype of ATLL, had a polypoid lesion in the middle portion of the oesophagus. Both cases had gastric involvement. Biopsies from these lesions revealed mucosal invasion of ATLL cells in each case. Combination chemotherapy was ineffective in both cases. Prospective and careful examination of additional cases may eventually provide specific advice for treatment of this unusual condition.
Isomoto
Hajime
H
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. hhisomot@net.nagasaki-i.ac.jp
Nishida
Yoshiyuki
Y
Fukuda
Hirotoshi
H
Matsuo
Yuji
Y
Omagari
Katsuhisa
K
Mizuta
Yohei
Y
Murase
Kunihiko
K
Murata
Ikuo
I
Kohno
Shigeru
S
D016099:Endoscopy, Gastrointestinal; D004947:Esophagus / Q000378:metabolism / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness