title: Moyamoya syndrome: impaired hemodynamics on ECD SPECT after EEG controlled hyperventilation.
abstract: OBJECTIVE
  Ischemic symptoms in children with Moyamoya syndrome are typically provoked by hyperventilation (HV) and are accompanied by the "re-build-up" phenomenon in EEG. The value of scintigraphic detection of HV-provoked perfusion deficits remains to be elucidated.
  
  
  METHODS
  In seven children with Moyamoya syndrome regional cerebral blood flow was assessed by 99mTc-ethyl-cysteine-dimer (ECD) single photon emission computed tomography (SPECT) after HV and under baseline conditions to identify ischemia prone regions.
  
  
  RESULTS
  Regional marked hypoperfusion after HV was found in all patients. Predominant perfusion deficits were detected in the frontal lobes.
  
  
  CONCLUSIONS
  ECD SPECT is a potential tool for the preoperative evaluation of cerebral hemodynamics and for monitoring angiosurgical therapies in Moyamoya disease.
authors.affiliation: Department of Nuclear Medicine, Münster University, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Matheja
authors.forename: M
authors.initials: M
authors.lastname: Weckesser
authors.forename: O
authors.initials: O
authors.lastname: Debus
authors.forename: Ch
authors.initials: Ch
authors.lastname: Franzius
authors.forename: J
authors.initials: J
authors.lastname: Löttgen
authors.forename: O
authors.initials: O
authors.lastname: Schober
authors.forename: G
authors.initials: G
authors.lastname: Kurlemann
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D001921:Brain / Q000000981:diagnostic imaging; D002648:Child; D003545:Cysteine / Q000031:analogs & derivatives*; D004569:Electroencephalography; D006439:Hemodynamics; D006801:Humans; D006985:Hyperventilation / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009072:Moyamoya Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine