[Animal model for Alzheimer's disease based on the blockade of neuronal nicotinic acetylcholine receptors].
The intrahippocampus injection of Kappa-bungarotoxin (K-BGT) caused a significant impairment in learning and memory abilities of mice, in order to create an animal model for Alzheimer's disease. The spatial learning and memory abilities in the Morris water maze in the model group (K-BGT impaired mice) decreased significantly compared with control group. K-BGT impaired mice also showed learning and memory reduction with shorter latency and more mistakes in step-through test.
Liu
J
J
Department of Biotechnology, Jinan University, Guangzhou 510632, China.
Xie
L
L
Hong
A
A
Chen
S
S
D000544:Alzheimer Disease / Q000139:chemically induced / Q000378:metabolism; D000818:Animals; D002038:Bungarotoxins; D004195:Disease Models, Animal; D018782:Maze Learning; D008568:Memory; D051379:Mice; D009474:Neurons / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism
D002038:Bungarotoxins; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic