title: Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity.
abstract: OBJECTIVE
  British dietary recommendations are to decrease total fat intake to less than 30 % of daily energy intake and saturated fat to less than 10 %. In practice, it is difficult for people to make these changes. It may be easier to encourage people to switch from a diet rich in saturated fatty acids to one rich in polyunsaturated fatty acids.
  
  
  METHODS
  A total of 17 subjects - six people with Type II (non-insulin-dependent) diabetes mellitus, six non-obese and five obese people without diabetes - were randomised to spend two 5-week periods on a diet rich in saturated or in polyunsaturated fatty acids, in a crossover design. At the start of the study and after each dietary period, we assessed abdominal fat distribution using magnetic resonance imaging, insulin sensitivity using hyperinsulinaemic-euglycaemic clamps and fasting lipid parameters.
  
  
  RESULTS
  Dietary compliance, assessed by weekly 3-day dietary records and measurement of biochemical markers, was good. Energy and fat intake appeared to be reduced on the diet rich in polyunsaturated fatty acids although body weights did not change. Insulin sensitivity and plasma low density lipoprotein cholesterol concentrations improved with the diet rich in polyunsaturated fatty acids compared with the diet rich in saturated fatty acids. There was also a decrease in abdominal subcutaneous fat area.
  
  
  CONCLUSIONS
  If this result is confirmed in longer-term studies, this dietary manipulation would be more readily achieved by the general population than the current recommendations and could result in considerable improvement in insulin sensitivity, reducing the risk of developing Type II diabetes.
authors.affiliation: Oxford Lipid Metabolism Group, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Infirmary, Oxford, UK.
authors.forename: L K M
authors.initials: LK
authors.lastname: Summers
authors.forename: B A
authors.initials: BA
authors.lastname: Fielding
authors.forename: H A
authors.initials: HA
authors.lastname: Bradshaw
authors.forename: V
authors.initials: V
authors.lastname: Ilic
authors.forename: C
authors.initials: C
authors.lastname: Beysen
authors.forename: M L
authors.initials: ML
authors.lastname: Clark
authors.forename: N R
authors.initials: NR
authors.lastname: Moore
authors.forename: K N
authors.initials: KN
authors.lastname: Frayn
mesh_terms: D000005:Abdomen; D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D001824:Body Constitution; D015992:Body Mass Index; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology* / Q000517:prevention & control; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D004734:Energy Metabolism; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000503:physiopathology; D012016:Reference Values; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D006442:Glycated Hemoglobin; D007328:Insulin