Plant cell cultures as a source of bioactive small molecules.
Plants have provided some of our most important pharmaceuticals and are a continuing source of novel bioactive molecules for drug development. Cell suspension cultures of higher plants are a complementary source of novel chemistry with significant advantages over whole plants, including plasticity of expression and re-accessibility. With an emphasis on recent progress, the use of plant cell cultures for both new lead discovery and as a route to the production of known bioactives will be described. Developments in strategies that can be applied to facilitate future success in the area are discussed.
Stafford
Angela M
AM
Phytera Ltd, Regent Court, Regent Street, Sheffield, S1 4DA, UK. a.m.stafford@sheffield.ac.uk
D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification; D002478:Cells, Cultured; D059828:Plant Cells; D010944:Plants / Q000378:metabolism; D015202:Protein Engineering
D001688:Biological Products