title: Selective serotonin reuptake inhibitor-induced rash: case report and review of the literature.
abstract: Selective serotonin reuptake inhibitors (SSRIs) are one of the most frequently prescribed classes of drugs. Rashes induced by SSRIs seldom have been reported in the literature. Computerized MEDLINE and Current Contents searches yielded a report of two cases of rash induced specifically by paroxetine. We describe a patient who developed a rash that appeared on day 3 of treatment with oral paroxetine 20 mg/day. Her rash was morbilliform, pruritic, and generalized over the trunk and limbs, with some facial involvement. There was no palm or sole involvement. The patient reported that she had experienced a similar reaction to fluoxetine, which may suggest a drug class effect. The rash resolved within 2 days of drug discontinuation and treatment with oral diphenhydramine and topical hydrocortisone cream.
authors.affiliation: Institute of Psychiatry, Medical University of South Carolina, Charleston 29425, USA.
authors.forename: Tracie J
authors.initials: TJ
authors.lastname: Sannicandro
authors.forename: Martha C
authors.initials: MC
authors.lastname: Farrar
authors.forename: John S
authors.initials: JS
authors.lastname: Markowitz
mesh_terms: D003865:Major Depressive Disorder / Q000188:drug therapy; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors