title: [Antimetastatic effects of arginine-aspartate on salivary adenoid cystic carcinoma in vitro].
abstract: OBJECTIVE
  To test the effects of arginine-aspartate (RD) on metastasis of salivary cystic carcinoma (SACC).
  
  
  METHODS
  Highly metastatic SACC cell line SACC-LM was used in the study. The effect of RD on tumor cell-ECM adhesion was assayed by MTT technique. The effect of RD on invasion and migration of SACC-LM were evaluated using modified boyden chamber.
  
  
  RESULTS
  RD inhibited tumor cell fibronectin adhesion at 5 mg/L concentration, but no effects on tumor cell laminin and tumor cell type IV collagen adhesion. RD inhibited the invasion at 1, 5, 25 mg/L, and inhibited the migration only at 25 mg/L.
  
  
  CONCLUSIONS
  The result shows that the RD has an antimetastatic effect on SACC-LM cells in vitro.
authors.affiliation: Department of Stomatology, International Peace Hospital, Shijiazhuang 050082, China.
authors.forename: F
authors.initials: F
authors.lastname: Li
authors.forename: G
authors.initials: G
authors.lastname: Yu
authors.forename: S
authors.initials: S
authors.lastname: Peng
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001120:Arginine / Q000494:pharmacology*; D001224:Aspartic Acid / Q000494:pharmacology*; D003528:Carcinoma, Adenoid Cystic / Q000188:drug therapy*; D002448:Cell Adhesion / Q000187:drug effects; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D012468:Salivary Gland Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D001224:Aspartic Acid; D001120:Arginine; C024891:arginine aspartate