CJ-15,696 and its analogs, new furopyridine antibiotics from the fungus Cladobotryum varium: fermentation, isolation, structural elucidation, biotransformation and antibacterial activities.
CJ-15,696 and 7 novel furopyridine antibiotics were isolated from the fungus Cladobotryum varium CL12284. Their structures were determined by X-ray crystallography and spectral analysis. Three biotransformed analogs were also prepared from CJ-15,696. CJ-15,696 showed moderate activity against various Gram-positive bacteria including some drug resistant strains such as methicillin resistant Staphylococcus aureus (MRSA).
Sakemi
Shinichi
S
Exploratory Medicinal Sciences, Pfizer Global Research and Development (PGRD)--Nagoya Laboratories, Pfizer Inc., Aichi, Japan. Shinichi.Sakemi@japan.pfizer.com
Bordner
Jon
J
DeCosta
Debra L
DL
Dekker
Koen A
KA
Hirai
Hideo
H
Inagaki
Taisuke
T
Kim
Yoon-Jeong
YJ
Kojima
Nakao
N
Sims
Jeffrey C
JC
Sugie
Yutaka
Y
Sugiura
Akemi
A
Sutcliffe
Joyce A
JA
Tachikawa
Kiyoshi
K
Truesdell
Susan J
SJ
Wong
John W
JW
Yoshikawa
Nobuji
N
Kojima
Yasuhiro
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001711:Biotransformation; D005285:Fermentation; D006094:Gram-Positive Bacteria; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents