title: Aspergillus galactomannan antigen in the cerebrospinal fluid of bone marrow transplant recipients with probable cerebral aspergillosis.
abstract: The Aspergillus galactomannan test was performed on cerebrospinal fluid and serum samples from 5 patients with probable cerebral aspergillosis and from 16 control patients. Cerebrospinal fluid galactomannan levels were significantly higher in aspergillosis patients, and most galactomannan was produced intrathecally. Comparison of serum galactomannan values in pulmonary and cerebral aspergillosis patients showed significant overlapping. Detection of Aspergillus galactomannan in cerebrospinal fluid may be diagnostic of cerebral aspergillosis.
authors.affiliation: Istituto Nazionale per la Ricerca sul Cancro, Dipartimento di Oncologia, Biologia e Genetica, Genoa, Italy. viscolic@unige.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Viscoli
authors.forename: Marco
authors.initials: M
authors.lastname: Machetti
authors.forename: Paola
authors.initials: P
authors.lastname: Gazzola
authors.forename: Andrea
authors.initials: A
authors.lastname: De Maria
authors.forename: Dimitri
authors.initials: D
authors.lastname: Paola
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Van Lint
authors.forename: Francesca
authors.initials: F
authors.lastname: Gualandi
authors.forename: Mauro
authors.initials: M
authors.lastname: Truini
authors.forename: Andrea
authors.initials: A
authors.lastname: Bacigalupo
mesh_terms: D000946:Antigens, Fungal / Q000032:analysis* / Q000097:blood; D001230:Aspergillus / Q000302:isolation & purification*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002540:Cerebral Cortex / Q000382:microbiology / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000382:microbiology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D008351:Mannans / Q000032:analysis* / Q000097:blood; D020953:Neuroaspergillosis / Q000175:diagnosis* / Q000382:microbiology
chemical_list: D000946:Antigens, Fungal; D008351:Mannans; C012990:galactomannan; D005690:Galactose