[Bidirectional cell traffic between mother and fetus: new insights in pediatric and adult disorders].
There is a heavy traffic of cells and DNA through the placenta during pregnancy. The rate of fetal cells in the maternal blood is correlated with abnormalities, such as aneuploidy and pre-eclampsia. Studying and quantifying these cells could improve antenatal diagnosis techniques, especially for Down syndrome. Maternal-fetal microchimerism is frequently observed in several auto-immune diseases in adulthood, such as systemic scleroderma. Studies suggest a rather allo-immune pathophysiology, involving maternal-fetal HLA compatibility. Microchimerism is also found in auto-immune diseases in children. Thus, the cells traffic offers new insights for antenatal diagnosis techniques and pathophysiology of auto-immune diseases.
Guillemin
M
M
Service de pédiatrie générale, centre Hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94010 Créteil, France. mguillemin@yahoo.fr
Reinert
P
P
D000328:Adult; D000782:Aneuploidy; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D002648:Child; D002678:Chimera; D004247:DNA / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D005333:Fetus / Q000166:cytology; D005865:Gestational Age; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy / Q000097:blood*; D011248:Pregnancy Complications / Q000209:etiology / Q000276:immunology; D011296:Prenatal Diagnosis / Q000379:methods*; D011297:Prenatal Exposure Delayed Effects; D012595:Scleroderma, Systemic / Q000276:immunology; D012756:Sheep
D004247:DNA
Trafic bidirectionnel de cellules entre mère et foetus: un éclairage nouveau dans les pathologies de l'adulte et de l'enfant.