Magnetic resonance imaging study of the swelling kinetics of hydroxypropylmethylcellulose (HPMC) in water.
Magnetic resonance imaging has been used to monitor the hydration of hydroxypropylmethylcellulose samples by two-dimensional mapping of properties such as spin density and relaxation times. The measurements were performed at two pH values of water: 2 and 6 and two temperatures 25 and 37 degrees C. It is shown that transport behavior of water into HPMC changes from being almost completely relaxation controlled (case II) at pH=2 to Fickian behavior for pH=6. It was also observed that radial swelling is larger for the system composed of HPMC and water at pH=6 than at pH=2.
Tritt-Goc
Jadwiga
J
Institute of Molecular Physics, Polish Academy of Sciences, M. Smoluchowskego 17, 60-179 Poznań, Poland. jtg@ifmpan.poznan.pl
Piślewski
Narcyz
N
D006490:Hemostatics / Q000737:chemistry / Q000493:pharmacokinetics; D065347:Hypromellose Derivatives; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data*; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000493:pharmacokinetics*; D012997:Solvents / Q000737:chemistry / Q000493:pharmacokinetics; D014867:Water / Q000737:chemistry*
D006490:Hemostatics; D012997:Solvents; D014867:Water; D065347:Hypromellose Derivatives; D008747:Methylcellulose