Intercellular adhesion, signalling and the cytoskeleton.
Connections between the cytoskeleton and intercellular junctions profoundly influence cell shape and motility. It is becoming increasingly clear that in addition to structural functions, components of the adhesion apparatus also possess signalling capabilities. Recent studies suggest that their dual function may provide the means to integrate changes in morphology and gene expression during tissue and organ development.
Jamora
Colin
C
Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.
Fuchs
Elaine
E
D022005:Adherens Junctions / Q000648:ultrastructure; D002448:Cell Adhesion; D003599:Cytoskeleton / Q000648:ultrastructure*; D003896:Desmosomes / Q000648:ultrastructure; D018507:Gene Expression Regulation, Developmental; D015603:Keratinocytes / Q000648:ultrastructure; D018613:Microscopy, Confocal; D008954:Models, Biological; D015398:Signal Transduction; D013997:Time Factors