Cytogenetic analysis in 139 Tunisian patients with de novo acute myeloid leukemia.
This paper presents the results of a cytogenetic analysis in 139 Tunisian patients with de novo acute myeloid leukemia (AML), including 27 children aged 1-15 years and 112 adults. Mean age was 32 (range 1-75) and the M/F ratio was 1.43. Of our patients, 45% had apparently normal karyotypes. Acquired chromosome aberrations were found in 77 (55% ) patients. t(8;21) was identified in 27 patients (19%); t(15;17) in 13 patients (9%); deletion 7q or monosomy 7 in seven patients (5%); +8 in seven patients (5%); abnormal 16 in four patients (3%); 11q23 rearrangements in two patients (2%) and del(5q), in one patient (1%). The remaining 16 patients had miscellaneous clonal abnormalities. Specific translocations associated with the FAB type were found: t(8;21) with AML2 and t(15;17) with AML3. We concluded that our study in a Tunisian population confirmed the relation between some specific abnormalities and the FAB classification. We found a higher incidence for t(8;21) than usually described.
Sendi
Halima Sennana
HS
Laboratoire de cytogénétique et de biologie de la reproduction, CHU Farhat Hached, Sousse, Tunisia.
Elghezal
Hatem
H
Temmi
Henda
H
Hichri
Haifa
H
Gribaa
Moez
M
Elomri
Halima
H
Meddeb
Belkiss
B
Ben Othmane
Tarek
T
Elloumi
Moez
M
Saad
Ali
A
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008875:Middle Aged; D014416:Tunisia