End-stage renal disease associated with familial Mediterranean fever.
A 39-year-old man had been suffering from periodic fever since childhood. He was started on hemodialysis due to secondary amyloidosis on December 2000. The patient was believed to have Familial Mediterranean fever (FMF) because of recurrent fever with peritonitis, arthritis and inflammatory changes and secondary amyloidosis in his kidneys, heart and colon. No other family member had recurrent fever. IL-6, TNF, and dopamine beta-hydroxylase were not increased in the febril phase. The patient was homozygous for the M6941 mutation. We report the first Japanese case of FMF associated with amyloidosis and confirmed by a gene mutation.
Tomiyama
Nozomi
N
Third Department of Internal Medicine, University of The Ryukyus, Okinawa.
Oshiro
Saori
S
Higashiuesato
Yasushi
Y
Yamazato
Masanobu
M
Sakima
Atushi
A
Tana
Takeshi
T
Tozawa
Masahiko
M
Muratani
Hiromi
H
Iseki
Kunitoshi
K
Takishita
Shuichi
S
D000328:Adult; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000235:genetics; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male