title: [Isolated decrease of haptoglobin during pregnancy: diagnosis by chance or pathological? ].
abstract: Haptoglobin is an acute-phase-protein, which is important in many diseases like infections, trauma and neoplasma. An increase in haptoglobin is induced by cytocines like IL-6 und IL-1. The normal range for plasmatic haptoglobin is 50-220 mg/dl. During pregnancy the most likely diagnosis is the HELLP- Syndrome (hemolysis, elevated liver enzymes and low platelets), followed by rare diagnoses like viral hepatitis or favism. We report about a 31-year-old III-gravida 0-para at 31 weeks of gestation with a decrease of haptoglobin over a period of 6 weeks (cut off: < 13 mg/dl) and without any clinical signs of preeclampsia. Liver enzymes were constantly slightly elevated without any progress, other laboratory test results were normal. The patient had a caesarean section at 37 weeks of gestation. Serum haptoglobin returned to normal values within three days after delivery. The reason for the decrease of haptoglobin in our case remains uncertain. Further studies need to focus on the differential diagnosis of a decrease of haptoglobin as well as an isolated decrease of haptoglobin during pregnancy and on the valid ranges of the different haptoglobin subtypes.
authors.affiliation: Zentrum für Frauenheilkunde und Geburtshilfe der J. W. G. Universität Frankfurt, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Gatzka
authors.forename: D
authors.initials: D
authors.lastname: Bremerich
authors.forename: M
authors.initials: M
authors.lastname: Kaufmann
authors.forename: A
authors.initials: A
authors.lastname: Ahr
mesh_terms: D000328:Adult; D002585:Cesarean Section; D003937:Diagnosis, Differential; D005260:Female; D005865:Gestational Age; D017359:HELLP Syndrome / Q000097:blood / Q000175:diagnosis; D006242:Haptoglobins / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D008111:Liver Function Tests; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000175:diagnosis*; D011272:Pregnancy, Multiple
chemical_list: D006242:Haptoglobins
vernacular_title: Isolierter Haptoglobinabfall in der Schwangerschaft: Zufallsbefund oder pathologisch? - Diskutiert anhand eines Fallberichtes -