title: Pharmacokinetics of multiple intravenous instillation of levofloxacin in Chinese healthy subjects.
abstract: OBJECTIVE
  To study the pharmacokinetics of multiple doses intravenous infusion of levofloxacin instillation in Chinese healthy volunteers.
  
  
  METHODS
  Intravenous infusion of levofloxacin instillation 200 mg within 60 min was given to 10 male healthy volunteers for 7 d, on d 1 and d 7, once-daily, from 2-6 d twice-daily dosing. The concentrations of levofloxacin in serum and urine were assayed by HPLC.
  
  
  RESULTS
  The main pharmacokinetic parameters af ter the first dosing were as follows: Cmax was (2.4+/-0.4) mg/L; AUC0- was (16.1 +/- 1.4) mg . h . L-1; T1/2beta was (6.3 +/- 0.3) h. The concentration in serum reached steady state within 72 h. The main parameters after the last dosing were as follows: Cssmax was (2.9 +/- 0.4) mg/L; Cssmin was (0.71 +/- 0.19) mg/L; Cav was (1.40 +/- 0.29) mg/L; AUCss0-12 was (17 +/- 3) mg . h . L-1; T1/2beta was (6.2 +/- 0.8) h. The 24-h cumulative urinary excretion rate was (88 +/- 5) %. From the calculation, the cumulative rate was 1.20; the fluctuation index was 1.30. The difference of T1/2beta and AUC between the first dosing and the last dosing was not significant, and the elimination rate of levofloxacin was not changed after multiple dosing. No clear adverse events were noted during this study.
  
  
  CONCLUSIONS
  There was no accumulation of drug after the repeated intravenous infusion with 200 mg levofloxacin instillation for 7 d.
authors.affiliation: Institute of Clinical Pharmacology, Peking University, Beijing 100083, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Jia-Tai
authors.initials: JT
authors.lastname: Li
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lu
authors.forename: Man-Ning
authors.initials: MN
authors.lastname: Li
authors.forename: Yong-Long
authors.initials: YL
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Tian-Yun
authors.initials: TY
authors.lastname: Li
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D044466:Asian People; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D007262:Infusions, Intravenous; D064704:Levofloxacin; D008297:Male; D015242:Ofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin