Aspergillus galactomannan antigen in the cerebrospinal fluid of bone marrow transplant recipients with probable cerebral aspergillosis.
The Aspergillus galactomannan test was performed on cerebrospinal fluid and serum samples from 5 patients with probable cerebral aspergillosis and from 16 control patients. Cerebrospinal fluid galactomannan levels were significantly higher in aspergillosis patients, and most galactomannan was produced intrathecally. Comparison of serum galactomannan values in pulmonary and cerebral aspergillosis patients showed significant overlapping. Detection of Aspergillus galactomannan in cerebrospinal fluid may be diagnostic of cerebral aspergillosis.
Viscoli
Claudio
C
Istituto Nazionale per la Ricerca sul Cancro, Dipartimento di Oncologia, Biologia e Genetica, Genoa, Italy. viscolic@unige.it
Machetti
Marco
M
Gazzola
Paola
P
De Maria
Andrea
A
Paola
Dimitri
D
Van Lint
Maria Teresa
MT
Gualandi
Francesca
F
Truini
Mauro
M
Bacigalupo
Andrea
A
D000946:Antigens, Fungal / Q000032:analysis* / Q000097:blood; D001230:Aspergillus / Q000302:isolation & purification*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002540:Cerebral Cortex / Q000382:microbiology / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000382:microbiology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D008351:Mannans / Q000032:analysis* / Q000097:blood; D020953:Neuroaspergillosis / Q000175:diagnosis* / Q000382:microbiology
D000946:Antigens, Fungal; D008351:Mannans; C012990:galactomannan; D005690:Galactose