title: Rectal administration of misoprostol for the management of retained placenta--a preliminary report.
abstract: BACKGROUND
  Retained placenta is one of the serious complications of childbirth, and misoprostol is known to be a potent uterotonic agent. Therefore, we proposed that rectal misoprostol also may facilitate placental separation in women with retained placenta by its ability to increase uterine contractility.
  
  
  METHODS
  The placenta was diagnosed as retained if it was not expelled within 40 minutes after vaginal birth. Then, 800 microg of misoprostol was inserted rectally and the patient observed thereafter.
  
  
  RESULTS
  A total of 18 parturients who had retention of the placenta were studied; all the placentas were spontaneously expelled within 35 minutes. The side effects involved included nausea 17%, vomiting 11%, diarrhea 22%, shivering 33%, and pelvic cramping pain 44%. All these discomforts resolved within 24 hours.
  
  
  CONCLUSIONS
  Our study demonstrated that misoprostol per rectum is a safe and effective technique and may be a useful alternative to manual removal of retained placentas.
authors.affiliation: Department of Obstetrics and Gynecology, Chung Shan Hospital, Taipei, Taiwan, ROC. drgynobs@yam.com
authors.forename: Y T
authors.initials: YT
authors.lastname: Li
authors.forename: C S
authors.initials: CS
authors.lastname: Yin
authors.forename: F M
authors.initials: FM
authors.lastname: Chen
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use*; D000328:Adult; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000009:adverse effects / Q000627:therapeutic use*; D018457:Placenta, Retained / Q000188:drug therapy*; D011247:Pregnancy
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol