Influence of piperacillin on pharmacokinetics of etimicin in healthy volunteers.
OBJECTIVE
To investigate the influence of piperacillin on the pharmacokinetics of etimicin.


METHODS
Ten healthy male volunteers subjects were administered randomly with 200 mg of etimicin alone or in combination with 2000 mg of piperacillin. After two weeks washout period, the subjects were crossed over to the second regimen. Blood and urinary samples were collected at specified time intervals. Etimicin concentration was analyzed using micro-bioassay method with Bacillus pumillus as the tested strain. Pharmacokinetic para-meters were determined from serum concentration-time data with the 3p87-software package.


RESULTS
Maximum serum concentrations of etimicin alone was (21 +/- 5) mg/L compared with (19 +/- 4) mg/L for the combination. The elimination half-lives were (1.9 +/- 0.4) h and (1.9 +/- 0.2) h for etimicin alone and in combination, respectively. The area under the concentration-time curve of etimicin alone was (38 +/- 7) mg . h . L-1 as opposed to (41 +/- 8) mg . h . L-1 in combination. Twelve hours after administration, urinary recovery rates of etimicin were (56 +/- 8) % and (56 +/- 6) % for etimicin alone and with piperacillin, respectively.


CONCLUSIONS
The results indicated that the pharmacokinetics of etimicin was not affected by concurrent administration of piperacillin in healthy male volunteers. No modification in dosing regimen is necessary when two drugs were co-administered.
Wang
Hai-Xue
HX
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 200032, China. haixue_wang@hotmail.com
Zhang
Li-Rong
LR
Ma
Xiao-Chao
XC
Ma
Tong-Xun
TX
D000328:Adult; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D010406:Penicillins / Q000494:pharmacology*; D010878:Piperacillin / Q000494:pharmacology*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D010406:Penicillins; C448680:etimicin; D010878:Piperacillin