title: Tamm-Horsfall protein excretion to predict the onset of renal insufficiency.
abstract: OBJECTIVE
  Immunosuppressive therapy after liver transplantation may be a risk for kidney dysfunction. This work was designed to determine whether Tamm-Horsfall Protein (THP) could be considered as a marker for nephrotoxicity.
  
  
  METHODS
  THP was determined by an ELISA method in serial 24-h urine from liver transplant patients. Fourteen patients suffered renal insufficiency (LTr(1)) and 20 showed no acute renal damage (LTr(2)) after liver transplantation.
  
  
  RESULTS
  No clear association could be seen between daily THP excretion and plasma creatinine levels by comparing serial samples collected at the same time. Nevertheless, significant differences were observed in pretransplant THP excretion between both groups of patients. The results (Median/Interquartile Range) were:
  
  
  METHODS
  113.2/84.9 to 146.8 mg/24 h (n = 30); LTr(1): 36.9/18.3 to 54.5 mg/24 h (p<<0.001 with respect to C and LTr(2)); LTr(2): 90.8/61.5 to 139.7 mg/24 h.
  
  
  CONCLUSIONS
  The higher pretransplant synthesis and/or secretion of THP seem to have a protective role on the kidney during and after liver transplantation.
authors.affiliation: Departmento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, (1428), Ciudad Autónoma de Buenos Aires, Argentina. cris@qb.fcen.uba.ar
authors.forename: María C
authors.initials: MC
authors.lastname: Romero
authors.forename: Noemí
authors.initials: N
authors.lastname: Zanaro
authors.forename: Liliana
authors.initials: L
authors.lastname: González
authors.forename: Pedro
authors.initials: P
authors.lastname: Trigo
authors.forename: Oscar
authors.initials: O
authors.lastname: Imventarza
authors.forename: Alcira
authors.initials: A
authors.lastname: Nesse
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine*; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007118:Immunoassay; D007668:Kidney / Q000502:physiology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009088:Mucoproteins / Q000652:urine*; D051437:Renal Insufficiency / Q000652:urine*; D013997:Time Factors; D058949:Uromodulin
chemical_list: D015415:Biomarkers; D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin; D003404:Creatinine