[Effect of cadmium on the beta-adrenoreceptor of splenic cell of rats and its immunotoxicity].
Rats were given cadmium(Cd) alone or Cd with beta-antagonist in order to study the effect of Cd on beta-adrenoreceptor density of rat splenic cells. The subsets of T-lymphocytes (CD4+, CD8+, CD4+/CD8+) and the proliferation of T lymphocytes were also detected. Cadmium alone stimulated and increased beta-adrenoreceptor density of rat splenic cell membrane. The immunotoxicity of Cd showed that the proliferation of T-lymphocytes was inhibited and the subsets of T cells were changed. But in the animals with beta-antagonist, the immunotoxicity of Cd on T cells was decreased. It is concluded that beta-adrenoreceptor may play an important role in the mechanism of cadmium on cell immunotoxicity.
Dong
S
S
Dept. of Environmental Health, Sun Yat-sen University of Medical Sciences, Guangzhou 510089, China.
Li
D
D
Yu
G
G
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D013154:Spleen / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D011943:Receptors, Adrenergic, beta; D002104:Cadmium