title: Selective colonization by Helicobacter pylori of the deep gastric glands and intracellular canaliculi of parietal cells in the setting of chronic proton pump inhibitor use.
abstract: Colonization by Helicobacter pylori of the acid-secreting tubules of gastric glands and the canaliculi of parietal cells has only rarely been reported. The presence of these organisms in such "deep" locations has only been reported in association with the more typical superficial colonization of the mucous gel layer overlying gastric epithelial cells. We report two cases of deep H. pylori infection without the presence of superficial organisms. Both patients had been using proton pump inhibitors for many years. We review the literature regarding the distribution of H. pylori within the stomach and the effect of proton pump inhibitor use on H. pylori distribution.
authors.affiliation: Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia. p.tagkalidis@pgrad.unimelb.edu.au
authors.forename: Peter P
authors.initials: PP
authors.lastname: Tagkalidis
authors.forename: Simon G
authors.initials: SG
authors.lastname: Royce
authors.forename: Finlay A
authors.initials: FA
authors.lastname: Macrae
authors.forename: Prithi S
authors.initials: PS
authors.lastname: Bhathal
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001562:Benzimidazoles / Q000008:administration & dosage; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D005752:Gastric Mucins / Q000378:metabolism; D005753:Gastric Mucosa / Q000382:microbiology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage; D000077402:Pantoprazole; D010295:Parietal Cells, Gastric / Q000382:microbiology*; D054328:Proton Pump Inhibitors; D013454:Sulfoxides / Q000008:administration & dosage
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D005752:Gastric Mucins; D054328:Proton Pump Inhibitors; D013454:Sulfoxides; D000077402:Pantoprazole; D009853:Omeprazole