title: How does sibutramine work?
abstract: Sibutramine offers three types of benefit in weight management: by enhancing weight loss, by improving weight maintenance and by reducing the comorbidities of obesity. The clinical effects of sibutramine are explained through its known mode of action as a serotonin (5-HT) and noradrenaline reuptake inhibitor (SNRI). This dual mechanism of action results in two synergistic physiological effects--a reduction in energy intake and an increase in energy expenditure, which combine to promote and maintain weight loss.
authors.affiliation: Department of Human Nutrition, University of Glasgow, Glasgow Royal Infirmary, UK. lean@clinmed.gla.ac.uk
authors.forename: M E
authors.initials: ME
authors.lastname: Lean
mesh_terms: D001067:Appetite Depressants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003503:Cyclobutanes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D009765:Obesity / Q000517:prevention & control*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology
chemical_list: D001067:Appetite Depressants; D003503:Cyclobutanes; D017367:Selective Serotonin Reuptake Inhibitors; C058254:sibutramine