title: Characterization of two New York City Jewish populations at six short tandem repeat loci.
abstract: The Hasidic and non-Hasidic Jewish communities of New York City represent two subpopulations with long-documented histories of restrictive marriage patterns and a high degree of endogamy. As part of a continuing study into their genetic structure, allele frequencies were determined for the six tetrameric short tandem repeat (STR) loci: FESFPS, F13AO1, vWA, CSF1PO, TPOX, and THO1. All loci were tested for Hardy-Weinberg equilibrium (HWE) by three tests: chi-square analysis, Monte Carlo chi-square analysis. and the exact test. The non-Hasidic population failed to meet HWE at the F13A01, FESFPS, and CSF1PO loci by all three tests. The Hasidic population also failed to meet HWE at the same loci by some of the tests. Comparison of the Hasidic to the non-Hasidic population using an R x C contingency table demonstrated a similarity at only the vWA locus. Significant differences exist when comparing the two Jewish populations to a reference Caucasian population.
authors.affiliation: Aurora Biosciences, San Diego, CA 92121, USA.
authors.forename: I
authors.initials: I
authors.lastname: Medintz
authors.forename: C
authors.initials: C
authors.lastname: Kingston
authors.forename: H
authors.initials: H
authors.lastname: Duran
authors.forename: L
authors.initials: L
authors.lastname: Barry
authors.forename: L
authors.initials: L
authors.lastname: Levine
authors.forename: L
authors.initials: L
authors.lastname: Kobilinsky
mesh_terms: D000483:Alleles; D016009:Chi-Square Distribution; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D007585:Jews / Q000235:genetics*; D009010:Monte Carlo Method; D009519:New York City; D016133:Polymerase Chain Reaction; D020080:Tandem Repeat Sequences / Q000235:genetics*