[Study on the hepatic toxicity of cerous nitrate in rats].
Rats were injected with a single dose of cerous nitrate Ce (NO3)3 (150 mg/kg) intra-peritoneally and killed at 3, 6, 12, 24 and 48 hours later. The results showed that the concentrations of protein and malondialdehyde (MDA) in liver increased, but the concentration of glutathione (GSH) and the activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione sulfatransferase (GSH-ST) decreased after Ce3+ administration. The results suggest that lipid peroxidation in liver may be an early consequence of Ce3+ exposure and the decrease of GSH might be considered as the cause of lipid peroxidation.
Yang
W
W
School of Chemical Engineering, Zhongshan University, Guangzhou 510275, China.
Wang
T
T
Lei
H
H
Yang
Y
Y
D000818:Animals; D002563:Cerium / Q000633:toxicity*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
C032786:cerium nitrate; D002563:Cerium; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase