title: Disseminated Cladophialophora bantiana infection in a heart transplant recipient.
abstract: Cerebral phaeohyphomycosis caused by Cladophialophora bantiana, a dematiaceous fungus, is a rare disease. The majority of cases have been reported among immunocompetent patients; only 4 cases have been published that describe transplantation patients. The overall prognosis is poor. Surgical therapy in combination with chemotherapy with itraconazole is recommended. We report the case of a heart transplant recipient with cutaneous, cerebral, and lung manifestation of Cladophialophora bantiana who died despite surgical and systemic, high-dosage itraconazole treatment.
authors.affiliation: Department of Cardiothoracic Surgery, University Hospital of Regensburg, Regensburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Keyser
authors.forename: Franz Xaver
authors.initials: FX
authors.lastname: Schmid
authors.forename: Hans Jörg
authors.initials: HJ
authors.lastname: Linde
authors.forename: Johannes
authors.initials: J
authors.lastname: Merk
authors.forename: Dietrich E
authors.initials: DE
authors.lastname: Birnbaum
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001344:Autopsy; D020314:Central Nervous System Fungal Infections / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D002531:Cerebellum / Q000382:microbiology; D002963:Cladosporium; D017809:Fatal Outcome; D016027:Heart Transplantation; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007668:Kidney / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010676:Phialophora; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole