title: [Acute herpetic hepatitis: clinico-pathological study of two cases].
abstract: Two cases of acute herpetic hepatitis affecting immunocompetent adults after surgery, are reported. They point out the relevance of liver biopsy for the diagnosis of these generally unrecognized infections. Liver biopsy allows not only diagnosis but also the identification of the virus on tissue sections with immunohistochemistry or in situ hybridization. The prognosis of herpetic hepatitis which can be correlated with the extension of apoptosis, remains poor despite the appearance of antiviral drugs. An apoptosis score could represent an interesting prognostic factor whose value remains to be assessed.
authors.affiliation: Service d'Anatomie Pathologique, Faculté de Médecine, 7, bd Jeanne-d'Arc, 21079 Dijon cedex, France. laurent.martin@ubourgogne.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Martin
authors.forename: Nalha
authors.initials: N
authors.lastname: Yaziji
authors.forename: Patrick
authors.initials: P
authors.lastname: Charve
authors.forename: François
authors.initials: F
authors.lastname: Lenfant
authors.forename: Patrick
authors.initials: P
authors.lastname: Hillon
authors.forename: Marie Sophie
authors.initials: MS
authors.lastname: Soubeyrand
authors.forename: Françoise
authors.initials: F
authors.lastname: Piard
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D001706:Biopsy; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000473:pathology / Q000821:virology*; D006561:Herpes Simplex / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008099:Liver / Q000473:pathology; D008297:Male; D011379:Prognosis
chemical_list: D000998:Antiviral Agents
vernacular_title: Hépatite herpétique aiguë