title: Chlamydia pneumoniae, systemic inflammation and the risk of venous thrombosis.
abstract: Inflammatory mediators are involved in activation of the coagulation system, and elevated plasma concentrations of IL-6 and IL-8 are associated with an increased risk of venous thrombosis. Using serologic and molecular biologic tests, we investigated in a case-control study on patients with recurrent venous thrombosis the association between Chlamydia (C) pneumoniae and venous thrombosis and we evaluated the relation between C. pneumoniae serology and the cytokines IL-6 and IL-8. The presence of C. pneumoniae antibody titers > or = 1:16 was not associated with an increased risk of venous thrombosis (odds ratio 0.8 95% CI, 0.4-1.7). Circulating C. pneumoniae-DNA was detected in only one patient and two control subjects. IgG antibody titers against C. pneumoniae were not correlated with the concentrations of IL-6 and IL-8. These results indicate that the inflammatory process shown in patients with venous thrombosis is not related to C. pneumoniae.
authors.affiliation: Reg Lab Medical Microbiology, Albert Schweitzer Hospital, Dordrecht, Netherlands. b.maraha@elisabeth.nl
authors.forename: B
authors.initials: B
authors.lastname: Maraha
authors.forename: M F
authors.initials: MF
authors.lastname: Peeters
authors.forename: B E
authors.initials: BE
authors.lastname: van Aken
authors.forename: M
authors.initials: M
authors.lastname: den Heijer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology*; D016993:Chlamydophila pneumoniae / Q000276:immunology* / Q000472:pathogenicity*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007159:Immunologic Tests; D007249:Inflammation / Q000150:complications / Q000473:pathology; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D020246:Venous Thrombosis / Q000150:complications* / Q000453:epidemiology / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D015850:Interleukin-6; D016209:Interleukin-8