title: Sec61beta--a component of the archaeal protein secretory system.
abstract: Sec61p/SecYEG complexes mediate protein translocation across membranes and are present in both eukaryotes and bacteria. Whereas homologues of Sec61alpha/SecY and Sec61gamma/SecE exist in archaea, identification of the third component (Sec61beta or SecG) has remained elusive. Using PSI-BLAST, the archaeal counterpart of Sec61beta has been detected. With the identification of the Sec61beta motif, functions for a universal family of archaeal proteins can be predicted and the archaeal translocon system can be definitively detected.
authors.affiliation: Howard Hughes Medical Institute and Dept of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9050, USA.
authors.forename: Lisa N
authors.initials: LN
authors.lastname: Kinch
authors.forename: Milton H
authors.initials: MH
authors.lastname: Saier
authors.forename: Nick V
authors.initials: NV
authors.lastname: Grishin
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D019843:Archaeal Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D000069816:SEC Translocation Channels; D017386:Sequence Homology, Amino Acid
chemical_list: D019843:Archaeal Proteins; D008565:Membrane Proteins; D000069816:SEC Translocation Channels