title: Intraarticular synovial sarcoma confirmed by SYT-SSX fusion transcript.
abstract: A case of intraarticular synovial sarcoma arising in the knee verified by detection of the tumor-specific SYT-SSX fusion transcript is described. Although it is extremely rare, synovial sarcoma may occur entirely within a joint space. The molecular assay for detecting a tumor-specific chimeric gene is a valuable tool for diagnosis of soft tissue sarcoma, especially for diagnostically difficult cases and tumors in unusual locations.
authors.affiliation: Department of Orthopaedic Surgery, Okayama Rosai Hospital, Okayama, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Namba
authors.forename: Akira
authors.initials: A
authors.lastname: Kawai
authors.forename: Noriko
authors.initials: N
authors.lastname: Naito
authors.forename: Yuki
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Shiro
authors.initials: S
authors.lastname: Hanakawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Inoue
mesh_terms: D019677:Artificial Gene Fusion; D014408:Biomarkers, Tumor / Q000235:genetics / Q000302:isolation & purification*; D002887:Chromosomes, Human, Pair 18; D005260:Female; D006801:Humans; D007719:Knee Joint; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000302:isolation & purification*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D014158:Transcription, Genetic; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor; D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein