Immunoneutralization and anti-idiotype production: two-sided applications of leptin.
The neuroendocrine and immune systems are linked through a complex bi-directional network, in which hormones modify immune function, and the immune system, through the action of cytokines, affects neuroendocrine responses involved in the maintenance of body homeostasis. The adipocyte-derived, peptide hormone leptin is a pleiotropic molecule belonging to the helical cytokine family. On pp. 182-187, Matarese et al. suggest the possibility of new leptin-based therapeutic strategies for the treatment of both infection and autoimmune disease.
De Fanti
Brant A
BA
Lamas
Oscar
O
Milagro
Fermin I
FI
Martínez-Ansó
Eduardo
E
Martínez
J Alfredo
JA
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis / Q000494:pharmacology* / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D005260:Female; D020738:Leptin / Q000276:immunology* / Q000502:physiology; D008297:Male; D051379:Mice; D009500:Neutralization Tests; D009752:Nutritional Status / Q000502:physiology; D051381:Rats
D000888:Antibodies, Anti-Idiotypic; D020738:Leptin