title: [Trends of OC use 1980-1999 in a German cohort of women].
abstract: BACKGROUND
  There is no doubt, oral contraceptives are a safe, reversible and commonly used method of contraception. Ever use is about 80 % in developed countries and current use of OCs about 40 %. Almost all information about prevalence of OC use came from cross-sectional studies and did not distinguish between high- and low-dose OCs. This paper deals with the prevalence of OC use as it was observed during lifetime of a large cohort of German women by calendar year and estrogen content.
  
  
  METHODS
  The prevalence of OC use between 1980 to 1999 was analysed on occasion of an interim analysis of the German cohort study on women's health. This analysis is based on more than 10 000 women with about 390 000 women-years of observation.
  
  
  RESULTS
  The proportion of women under the age of 50, that ever used OCs, increased steeply from 1980, i. e. from 62 % (1980) to about 90 % from 1996 onward. The proportion of current users in a given calendar year rose from 44 % (1980) to 49 % (1991-95) and dropped after the "pill crisis 1995". The percentage of current users who used high-estrogen-dose OCs dropped from 32 % (1980) to 5 % (1999). In contrast, the percentage of users of low-dose OCs of the 2nd generation steeply increased as was the percentage of users of the 3rd generation pills, however the latter dropped after 1995.
  
  
  CONCLUSIONS
  The high acceptance of oral contraceptives despite many "pill crises" underlines the continuously high appreciation of their efficacy on the one hand, but underscores also the high responsibility of physicians and industry concerning surveillance or reduction of discussed side effects.
authors.affiliation: ZEG - Zentrum für Epidemiologie & Gesundheitsforschung Berlin, Berlin, Germany. heinemann@zeg-berlin.de
authors.forename: K
authors.initials: K
authors.lastname: Heinemann
authors.forename: S
authors.initials: S
authors.lastname: Moehner
authors.forename: M
authors.initials: M
authors.lastname: Lewis
authors.forename: A
authors.initials: A
authors.lastname: Assmann
authors.forename: E
authors.initials: E
authors.lastname: Garbe
authors.forename: L A J
authors.initials: LA
authors.lastname: Heinemann
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D003276:Contraceptives, Oral / Q000737:chemistry / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D004363:Drug Utilization / Q000639:trends; D004967:Estrogens / Q000032:analysis; D005260:Female; D005858:Germany; D006801:Humans; D008875:Middle Aged
chemical_list: D003276:Contraceptives, Oral; D004967:Estrogens
vernacular_title: Trend der OC-Nutzung in einer Deutschen Frauen-Kohorte 1980-1999 - Ergebnisse der Deutschen Kohortenstudie zur Frauengesundheit.