title: [Breast cancer: an overview of factors affecting the onset and development of the disease].
abstract: Breast cancer is the most common malignancy in women. The number of affected individuals is raising and the age at the onset has shifted towards younger age groups. Therefore, it is of great importance to improve primary and secondary prevention of breast cancer. New techniques of molecular biology significantly increased our understanding about the onset and progression of especially familial breast cancer. Further research in areas of molecular genetics and epidemiology is needed to find reliable diagnostic tools for screening of population groups to identify individuals at high risk of breast cancer. The follow up of interaction of various predisposing genes and environmental factors in breast cancer pathogenesis is of considerable public health importance as well. Some of risk factors covering areas of lifestyle and genetics are listed in this review as well as a survey of screening approaches and future prospects.
authors.affiliation: Centrum hygieny práce a nemocí z povolání, Státní zdravotní ústav, Praha.
authors.forename: T
authors.initials: T
authors.lastname: Borovanová
authors.forename: P
authors.initials: P
authors.lastname: Soucek
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D016147:Genes, Tumor Suppressor; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D015994:Incidence; D012307:Risk Factors
chemical_list: D005819:Genetic Markers
vernacular_title: Rakovina prsu: prehled faktorů ovlivnujících vznik a rozvoj onemocnĕní.