A European study on the relationship between antimicrobial use and antimicrobial resistance.
In Europe, antimicrobial resistance has been monitored since 1998 by the European Antimicrobial Resistance Surveillance System (EARSS). We examined the relationship between penicillin nonsusceptibility of invasive isolates of Streptococcus pneumoniae and antibiotic sales. Information was collected on 1998-99 resistance data for invasive isolates of S. pneumoniae to penicillin, based on surveillance data from EARSS and on outpatient sales during 1997 for beta-lactam antibiotics and macrolides. Our results show that in Europe antimicrobial resistance of S. pneumoniae to penicillin is correlated with use of beta-lactam antibiotics and macrolides.
Bronzwaer
Stef L A M
SL
National Institute of Public Health and the Environment, Department of Infectious Disease Epidemiology, Postbak 75, PO Box 1, Antonie van Leeuwenhoeklaan 9, 3720 BA Bilthoven, the Netherlands. stef.bronzwaer@rivm.nl
Cars
Otto
O
Buchholz
Udo
U
Mölstad
Sigvard
S
Goettsch
Wim
W
Veldhuijzen
Irene K
IK
Kool
Jacob L
JL
Sprenger
Marc J W
MJ
Degener
John E
JE
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004363:Drug Utilization / Q000706:statistics & numerical data*; D005060:Europe; D006801:Humans; D007769:Lactams; D016014:Linear Models; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D007769:Lactams