Treatment of plastic bronchitis in a Fontan patient with tissue plasminogen activator: a case report and review of the literature.
Plastic bronchitis is a condition in which large, bronchial casts with rubber-like consistency develop in the tracheobronchial tree and cause airway obstruction. We describe a 4-year-old girl who had Fontan physiology and who developed plastic bronchitis and report for the first time the use of aerosolized tissue plasminogen activator for treatment of this condition. The literature is reviewed with emphasis placed on the occurrence of this disorder in patients with single ventricle physiology.
Costello
John M
JM
Division of Cardiology, Children's Memorial Hospital, Northwestern University Medical School, Chicago, Illinois 60614, USA.
Steinhorn
David
D
McColley
Susanna
S
Gerber
Mark E
ME
Kumar
Sulekha P
SP
D000280:Administration, Inhalation; D001991:Bronchitis / Q000188:drug therapy* / Q000209:etiology* / Q000601:surgery; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D018729:Fontan Procedure; D006330:Heart Defects, Congenital / Q000150:complications* / Q000601:surgery*; D006801:Humans; D000860:Hypoxia / Q000209:etiology*; D009422:Nervous System Diseases / Q000209:etiology; D012008:Recurrence; D012074:Remission Induction; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
D010959:Tissue Plasminogen Activator