High free energy of lipid/protein interaction in biological membranes.
The free energy of lipid/protein interaction in biological membranes is still unknown although extensive partitioning and modelling studies have revealed many partial energetic increments. Multiple site binding kinetics are now applied to four well-studied functional membrane proteins, and mean free energy values (+/-S.D.) of -4.23+/-0.49 kcal/mol for single lipid binding sites and of -89.7+/-35.4 kcal/mol for complete lipid substitution are obtained. These high free energy values point to an important bioenergetic role of lipid/protein interaction in membrane functions.
Sandermann
Heinrich
H
GSF-National Research Center for Environment and Health, Institute for Biochemical Plant Pathology, D-85764 Neuherberg, Germany. sandermann@gsf.de
D001665:Binding Sites; D002462:Cell Membrane / Q000737:chemistry*; D004734:Energy Metabolism; D008055:Lipids / Q000737:chemistry*; D008954:Models, Biological; D011485:Protein Binding / Q000502:physiology; D011506:Proteins / Q000737:chemistry*; D013816:Thermodynamics
D008055:Lipids; D011506:Proteins