title: Diastolic blood pressure-estimated left ventricular dp/dt.
abstract: BACKGROUND
  Peak dp/dt is one of the best isovolumic phase indexes of the myocardial contractile state requiring invasive procedures or presence of mitral regurgitation severe enough to measure in clinical practice by Doppler echocardiography. In this study, we sought the correlation between two noninvasive methods of measurements for left ventricular dp/dt-diastolic blood pressure- (DBP) estimated and continuous-wave Doppler-derived dp/dt-min electrocardiographic/echocardiographic study to emphasize the clinical feasibility of the DBP-estimated method.
  
  
  METHODS
  Thirty-six randomized patients (27 male, 9 female; 58 +/- 8 years) with mild mitral regurgitation were enrolled in this study. DBP-estimated dp/dt was calculated from DBP minus the left ventricular end-diastolic pressure (LVEDP) over the isovolumetric contraction time (IVCT). LVEDP was assumed to be 10 mmHg for all patients. Doppler-determined left ventricular dp/dt was derived from the continuous-wave Doppler spectrum of mitral regurgitation jet by dividing the magnitude of the left ventricular atrial pressure gradient rise between 1 mm/sec-3 mm/sec of mitral regurgitant velocity signal by the time taken for this change.
  
  
  RESULTS
  Left ventricular dp/dt by Doppler was 1122 +/- 303 mmHg/sec and blood pressure-estimated dp/dt was 1063 +/- 294 mmHg/sec. There was a high correlation (r = 0.97, P < 0.001) of dp/dt between the two techniques.
  
  
  CONCLUSIONS
  DBP and IVCT can generate left ventricular dp/dt without invasive procedures, even in the absence of mitral regurgitation in clinical practice.
authors.affiliation: Akdeniz University, Department of Cardiology, Antalya, Turkey. drhy@um.turkcell.com.tr
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Yilmaz
authors.forename: Kenan
authors.initials: K
authors.lastname: Minareci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kabukçu
authors.forename: Oktay
authors.initials: O
authors.lastname: Sancaktar
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D003971:Diastole / Q000502:physiology; D015150:Echocardiography, Doppler; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology; D013223:Statistics as Topic; D013318:Stroke Volume / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology*