title: Beneficial effects of tandospirone on ataxia of a patient with Machado-Joseph disease.
abstract: Tandospirone citrate (tandospirone) is an anti-anxiety drug that acts by combining with serotonin receptor (5-hydroxytryptamine-1 A [5-HT1A]). Recently, there have been a few reports of its potential role in the treatment of cerebellar ataxia. We report the first case of a patient with Machado-Joseph disease in which we successfully treated cerebellar ataxia. In addition, his leg pain, insomnia, anorexia, and depression, which are thought to be related to 5-HT1A receptors, were also remarkably alleviated by treatment with tandospirone.
authors.affiliation: Hokuyukai Neurology Hospital, Sapporo, Japan. atakei@med.hokudai.ac.jp
authors.forename: Asako
authors.initials: A
authors.lastname: Takei
authors.forename: Sanae
authors.initials: S
authors.lastname: Honma
authors.forename: Atushi
authors.initials: A
authors.lastname: Kawashima
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yabe
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Fukazawa
authors.forename: Keiko
authors.initials: K
authors.lastname: Hamada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hamada
authors.forename: Kunio
authors.initials: K
authors.lastname: Tashiro
mesh_terms: D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002524:Cerebellar Ataxia / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D054833:Isoindoles; D017827:Machado-Joseph Disease / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D044263:Receptors, Serotonin, 5-HT1; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D054833:Isoindoles; D010879:Piperazines; D011743:Pyrimidines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; C055267:tandospirone