Chemotherapy-induced peripheral neuropathy.
The induction of peripheral neuropathy is a common factor in limiting therapy with chemotherapeutic drugs. Little is known about the mechanisms responsible for the development of neuropathy. Depending on the substance used, a pure sensory and painful neuropathy (with cisplatin, oxaliplatin, carboplatin) or a mixed sensorimotor neuropathy with or without involvement of the autonomic nervous system (with vincristine, taxol, suramin) can ensue. Neurotoxicity depends on the total cumulative dose and the type of drug used. In individual cases neuropathy can evolve even after a single drug application. A general predisposition for developing a chemotherapy-induced neuropathy has been observed in nerves previously damaged by diabetes mellitus, alcohol or inherited neuropathy. The recovery from symptoms is often incomplete and a long period of regeneration is required to restore function. Up to now, no drug is available to reliably prevent or cure chemotherapy-induced neuropathy.
Quasthoff
Stefan
S
Department of Neurology, Karl-Franzens Universität Graz, Austria. Stefan.Quasthoff@kfunigraz.ac.at
Hartung
Hans Peter
HP
D000970:Antineoplastic Agents / Q000633:toxicity*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000633:toxicity; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D009437:Neuralgia / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D010525:Peripheral Nerves / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D017671:Platinum Compounds / Q000633:toxicity; D013498:Suramin / Q000633:toxicity; D014750:Vincristine / Q000633:toxicity
D000970:Antineoplastic Agents; D017671:Platinum Compounds; D014750:Vincristine; D013498:Suramin