title: Mineral and nitrogen metabolic studies on Skylab flights and comparison with effects of earth long-term recumbency.
abstract: A metabolic study of the effects of space flight on various chemical elements, particularly those with special relevance to the musculo-skeletal system, was carried out on the nine astronauts who participated in the three Skylab flights of 28, 59 and 84 days in 1973-1974. The study required of the cooperating crewmen constant dietary intake, continuous 24-hour urine collections and total fecal collections for 21-31 days before each flight, throughout each flight and for 17-18 days post-flight. Increases in urinary calcium and negative calcium balances during space flight were generally similar to those found in previous immobilization and bedrest studies. The persistence of these alterations in calcium metabolism throughout the flights suggested that calcium losses would continue in weightlessness for a very long time. Significant losses of nitrogen and phosphorus occurred, associated with observed reduction in muscle tissue. Both mineral and muscle losses occurred despite vigorous exercise regimens in flight. It was concluded that unless protective measures can be developed, capable musculo-skeletal function is likely to be impaired in space flights, ultimately to be conducted to Mars, of 11/2 to 3 years duration.
authors.affiliation: National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Md, USA.
authors.forename: G D
authors.initials: GD
authors.lastname: Whedon
authors.forename: L
authors.initials: L
authors.lastname: Lutwak
authors.forename: P
authors.initials: P
authors.lastname: Rambaut
authors.forename: M
authors.initials: M
authors.lastname: Whittle
authors.forename: C
authors.initials: C
authors.lastname: Leach
authors.forename: J
authors.initials: J
authors.lastname: Reid
authors.forename: M
authors.initials: M
authors.lastname: Smith
mesh_terms: D001510:Bed Rest; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism* / Q000652:urine; D003404:Creatinine / Q000652:urine; D004435:Eating; D005243:Feces; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D007103:Immobilization; D008297:Male; D008903:Minerals / Q000378:metabolism* / Q000652:urine; D009133:Muscular Atrophy / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism / Q000652:urine; D010758:Phosphorus / Q000378:metabolism / Q000652:urine; D013026:Space Flight; D014893:Weightlessness; D018474:Weightlessness Simulation
chemical_list: D008903:Minerals; D010758:Phosphorus; D003404:Creatinine; D009584:Nitrogen; D006909:Hydroxyproline; D002118:Calcium