A new biologically active malyngamide from a New Zealand collection of the sea hare Bursatella leachii.
A new malyngamide, S (1), was isolated from a New Zealand collection of the sea hare Bursatella leachii and structurally characterized by spectroscopic methods and chemical degradation. Malyngamide S exhibited cytotoxicity and antiinflammatory properties.
Appleton
David R
DR
Department of Chemistry and School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
Sewell
Mary A
MA
Berridge
Michael V
MV
Copp
Brent R
BR
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003512:Cyclohexanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D008974:Mollusca / Q000737:chemistry*; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D014407:Tumor Cells, Cultured / Q000187:drug effects
C457259:7S-methoxydodec-4E-enoic acid; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D003512:Cyclohexanones; D005229:Fatty Acids, Monounsaturated; C457260:malyngamide S