title: Spectrum-analysis and neural networks for imaging to detect and treat prostate cancer.
abstract: Conventional B-mode ultrasound currently is the standard means of imaging the prostate for guiding prostate biopsies and planning brachytherapy to treat prostate cancer. Yet B-mode images do not adequately display cancerous lesions of the prostate. Ultrasonic tissue-type imaging based on spectrum analysis of radiofrequency (rf) echo signals has shown promise for overcoming the limitations of B-mode imaging for visualizing prostate tumors. This method of tissue-type imaging utilizes nonlinear classifiers, such as neural networks, to classify tissue based on values of spectral parameter and clinical variables. Two- and three-dimensional images based on these methods demonstrate potential for guiding prostate biopsies and targeting radiotherapy of prostate cancer. Two-dimensional images are being generated in real time in ultrasound scanners used for real-time biopsy guidance and have been incorporated into commercial dosimetry software used for brachytherapy planning. Three-dimensional renderings show promise for depicting locations and volumes of cancer foci for disease evaluation to assist staging and treatment planning, and potentially for registration or fusion with CT images for targeting external-beam radiotherapy.
authors.affiliation: Biomedical Engineering Laboratories, Riverside Research Institute, New York, NY 10038, USA. feleppa@rrinyc.org
authors.forename: E J
authors.initials: EJ
authors.lastname: Feleppa
authors.forename: R D
authors.initials: RD
authors.lastname: Ennis
authors.forename: P B
authors.initials: PB
authors.lastname: Schiff
authors.forename: C S
authors.initials: CS
authors.lastname: Wuu
authors.forename: A
authors.initials: A
authors.lastname: Kalisz
authors.forename: J
authors.initials: J
authors.lastname: Ketterling
authors.forename: S
authors.initials: S
authors.lastname: Urban
authors.forename: T
authors.initials: T
authors.lastname: Liu
authors.forename: W R
authors.initials: WR
authors.lastname: Fair
authors.forename: C R
authors.initials: CR
authors.lastname: Porter
authors.forename: J R
authors.initials: JR
authors.lastname: Gillespie
mesh_terms: D001706:Biopsy; D001918:Brachytherapy / Q000379:methods; D006801:Humans; D021621:Imaging, Three-Dimensional; D016014:Linear Models; D008297:Male; D016571:Neural Networks, Computer; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D012372:ROC Curve; D011880:Radiotherapy Planning, Computer-Assisted; D012815:Signal Processing, Computer-Assisted; D014463:Ultrasonography