[GABA inhibits progesterone production of luteal cells of rat ovary].
In the present work we report that GABA inhibits progesterone production and increases the amount of hydroxyl radical in cultured rat luteal cells. The inhibitory effect of GABA on progesterone production may be mediated by adenylate cyclase system and GABA(A) receptor, but not through protein synthesis pathway.
Zhang
H
H
Division of Reproduction and Endocrinology, Department of Physiology, Harbin Medical University, Harbin 150086, China.
Ni
J
J
Zhang
W
W
Tian
S J
SJ
D000262:Adenylyl Cyclases / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D005260:Female; D008184:Luteal Cells / Q000378:metabolism*; D011374:Progesterone / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D018079:Receptors, GABA / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D018079:Receptors, GABA; D011374:Progesterone; D005680:gamma-Aminobutyric Acid; D000262:Adenylyl Cyclases