title: Polymorphisms of chromogranin B gene associated with schizophrenia in Chinese Han population.
abstract: Chromogranin is a widespread family of proteins in the neurosystem, whose function is guiding the sorting and secretion of neuropeptides. Using functional and positional evidences, chromogranin B was selected as a candidate gene for schizophrenia. We systematically screened all the promoter and exon regions of the gene and detected 15 single nucleotide polymorphisms (SNPs), among which four SNPs (including two non-synonymous SNPs) were selected for association analysis. In a cohort of Chinese Han schizophrenia cases and controls, the results of both the individual SNPs and the haplotypes of SNPs were significantly positive (P<0.01). Our results confirm the role of neuropeptides in the pathogenesis of schizophrenia.
authors.affiliation: Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 200030, PR China.
authors.forename: Bifeng
authors.initials: B
authors.lastname: Zhang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Tan
authors.forename: Changshun
authors.initials: C
authors.lastname: Zhang
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Shi
authors.forename: Zhixin
authors.initials: Z
authors.lastname: Lin
authors.forename: Niufan
authors.initials: N
authors.lastname: Gu
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence / Q000235:genetics; D002490:Central Nervous System / Q000378:metabolism* / Q000503:physiopathology; D002681:China / Q000208:ethnology; D053378:Chromogranin B; D002864:Chromogranins / Q000235:genetics* / Q000378:metabolism; D004252:DNA Mutational Analysis; D005091:Exons / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D009479:Neuropeptides / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C506134:CHGB protein, human; D053378:Chromogranin B; D002864:Chromogranins; D005819:Genetic Markers; D009479:Neuropeptides