Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats.
Rats display conditioned rejection reactions during an oral infusion of a flavor previously paired with an emetic drug; considerable evidence indicates that these rejection reactions reflect nausea. Here we report that cannabidiol, a major non-psychoactive cannabinoid found in marijuana and its synthetic dimethylheptyl homolog interfere with nausea elicited by lithium chloride and with conditioned nausea elicited by a flavor paired with lithium chloride. These results suggest that cannabinoids without psychoactive side-effects may have therapeutic value in the treatment of chemotherapy-induced nausea.
Parker
Linda A
LA
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5, Canada.
Mechoulam
Raphael
R
Schlievert
Coralynne
C
D000818:Animals; D002185:Cannabidiol / Q000627:therapeutic use*; D002186:Cannabinoids / Q000627:therapeutic use*; D002188:Cannabis; D004195:Disease Models, Animal; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008297:Male; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy / Q000379:methods*; D028321:Plant Preparations / Q000627:therapeutic use; D011619:Psychotropic Drugs / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
D002186:Cannabinoids; D028321:Plant Preparations; D011619:Psychotropic Drugs; D002185:Cannabidiol; C007472:3-(1,2-dimethylheptyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo(b,d)pyran-1-ol; D013759:Dronabinol