title: Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia?
abstract: Eighty-six patients with tumour induced hypercalcaemia were randomised to 600, 900, 1200 or 1500 mg of intravenous clodronate, according to post hydration serum calcium levels. Sixty-seven were evaluable for response. The overall response rate was 49.3% (95% CI: 36.8-61.8) with no significant difference in response rates, i.e. achievement of normocalcaemia at days 6-9 (corrected serum calcium < or =2.6 mmol l(-1)) across all groups.
authors.affiliation: Department of Palliative Medicine, The Royal Marsden NHS Trust, Sutton SM2 5PT, Surrey, UK.
authors.forename: S
authors.initials: S
authors.lastname: Shah
authors.forename: Janet
authors.initials: J
authors.lastname: Hardy
authors.forename: E
authors.initials: E
authors.lastname: Rees
authors.forename: J
authors.initials: J
authors.lastname: Ling
authors.forename: B
authors.initials: B
authors.lastname: Gwilliam
authors.forename: C
authors.initials: C
authors.lastname: Davis
authors.forename: K
authors.initials: K
authors.lastname: Broadley
authors.forename: R
authors.initials: R
authors.lastname: A'Hern
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000097:blood; D004002:Clodronic Acid / Q000008:administration & dosage* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000150:complications*
chemical_list: D004002:Clodronic Acid; D002118:Calcium