The relationships among ultrastructural angiogenic features, Na+ K+, Ca+2, Mg+2 ATP-ase activities and SOD concentration in the microvasculature of intracranial meningiomas and glial tumors.
The purpose of this study was to investigate the relationship among ultrastructural angiogenic features, adenosine-5'-triphosphatase (ATP-ase) activities and superoxide dismutase (SOD) concentration in the microvasculature of intracranial meningiomas and glial tumors. We examined 20 tumor materials from 20 adult patients with intracranial meningioma or glial tumor who underwent selective surgery, dividing them into two groups based on the type of the tumors. Group I consisted of 10 meningioma-materials, and Group II of 10 glial tumor-materials. Na+-K+, Mg+2 and Ca+2 ATP-ase activities in Group I were significantly higher than those in Group II (p < 0.01). The SOD activity in Group I was significantly lower than that in Group II (p < 0.01). According to electron microscopic findings, vascular endothelial proliferation and ultrastructural cytoplasmic changes in the glial tumors were more prominent than those in the meningiomas. Our results show that there is a meaningful correlation among an increased endothelial proliferation, a decreased ATP-ase level and an increased SOD activity in the meningiomas and glial tumors.
Tuna
Metin
M
Department of Neurosurgery, Cukurova University School of Medicine, Adana, Turkey. metnus@superonline.com
Polat
Sait
S
Ildan
Faruk
F
Göçer
A Iskender
AI
Erman
Tahsin
T
Tamer
Lülüfer
L
Haciyakupoglu
Sebahattin
S
D000328:Adult; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D005910:Glioma / Q000098:blood supply* / Q000201:enzymology* / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008579:Meningioma / Q000098:blood supply* / Q000201:enzymology* / Q000473:pathology / Q000648:ultrastructure; D008833:Microcirculation / Q000201:enzymology / Q000648:ultrastructure; D008854:Microscopy, Electron; D009389:Neovascularization, Pathologic / Q000201:enzymology / Q000473:pathology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000378:metabolism*
D013482:Superoxide Dismutase; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase