title: Antitubercular activity of pentacyclic triterpenoids from plants of Argentina and Chile.
abstract: Screening of plants from South America for antitubercular activity and subsequent assay-guided fractionation resulted in the isolation and characterization of several pentacyclic triterpenoids. The MIC values of 22 triterpenoids were determined using the radiorespiratory BACTEC assay and range from 8 microM to above 128 microM. The structure-activity relationships are discussed.
authors.affiliation: Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson 85721, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Wächter
authors.forename: S
authors.initials: S
authors.lastname: Valcic
authors.forename: M L
authors.initials: ML
authors.lastname: Flagg
authors.forename: S G
authors.initials: SG
authors.lastname: Franzblau
authors.forename: G
authors.initials: G
authors.lastname: Montenegro
authors.forename: E
authors.initials: E
authors.lastname: Suarez
authors.forename: B N
authors.initials: BN
authors.lastname: Timmermann
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001118:Argentina; D002677:Chile; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D014315:Triterpenes