Hepatocyte growth factor (HGF) as a rapid diagnostic marker and its potential in the prevention of acute renal rejection.
Several investigators have reported that hepatocyte growth factor (HGF) may be related to the protection or reconstruction of the kidney during acute renal rejection. To address this question, we examined the relationship between HGF and acute rejection in the following two studies with rat renal transplantation models. In study 1, the relationship between serum HGF levels and acute renal rejection in iso-, allo- and allograft with cyclosporine (CsA)-treated models was examined. In study 2, the focus was whether or not the injection of recombinant HGF can prevent acute renal rejection. Our results demonstrated that HGF levels were rapidly increased during acute rejection and that recombinant HGF effectively protected the kidney from acute rejection. These results suggest that HGF may be induced as a counter-response to the renal injury and that it can be used as a reliable indicator for the diagnosis of acute rejection. We suggest that recombinant HGF suppresses the onset of the pathological changes of acute rejection.
Yoshimura
Rikio
R
Department of Urology, Osaka City University Hospital, 1-4-3 Asahi-machi, Abenoku, Osaka 545-8585, Japan. hasetaro@msic.med.osaka-cu.ac.jp
Watanabe
Yoshihiro
Y
Kasai
Sinji
S
Wada
Seiji
S
Ohyama
Akira
A
Hase
Taro
T
Nakatani
Tatsuya
T
Chargui
Jamel
J
Touraine
Jean-Louis
JL
Nakamura
Toshikazu
T
D000208:Acute Disease; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D006084:Graft Rejection / Q000473:pathology / Q000517:prevention & control*; D017228:Hepatocyte Growth Factor / Q000032:analysis* / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D017208:Rats, Wistar; D014184:Transplantation, Homologous / Q000276:immunology; D014185:Transplantation, Isogeneic / Q000276:immunology
D015415:Biomarkers; D007166:Immunosuppressive Agents; D017228:Hepatocyte Growth Factor