[Nucleic acid and protein content in rat prostate during combined treatment with the gonadorelin agonist and an androgen receptor inhibitor].
The effects of androgen receptor blocker Flutamide (Niftolide) and/or LH-releasing hormone agonist Surfagon on the nucleic acids and protein contents in the ventral prostate of male rats were studied. It was shown that combined drug treatment led to potentiating of "antiprostatic" effects of both preparations resulted in significant decrease of DNA, RNA and protein contents.
Sachyns'ka
O V
OV
V.P. Komissarenko Institute of Endocrinology and Metabolism, Academy of Medical Sciences of Ukraine, Kiev.
D000726:Androgen Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005485:Flutamide / Q000008:administration & dosage / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000819:agonists / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006728:Hormones / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D009696:Nucleic Acids / Q000378:metabolism*; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D000726:Androgen Antagonists; D006728:Hormones; D009696:Nucleic Acids; D011506:Proteins; D007987:Gonadotropin-Releasing Hormone; C010661:surfagon; D005485:Flutamide