The hyaluronan receptor, CD44.
CD44 is a widely expressed cell surface hyaluronan receptor which plays a key role in mediating cell migration. A number of recent papers demonstrating an interplay between CD44 and matrix metalloproteinases (MMPs) have shed important insights into the molecular mechanisms underlying these events. This has important implication for understanding how mis-regulation of CD44 can contribute to disease pathologies.
Isacke
Clare M
CM
The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK. c.isacke@icr.ac.uk
Yarwood
Helen
H
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D018960:Hyaluronan Receptors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006820:Hyaluronic Acid / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008954:Models, Biological; D015394:Molecular Structure
D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid; D020782:Matrix Metalloproteinases