Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation.
Active suppression by T regulatory cells plays an important role in the down-regulation of T cell responses to foreign and self-Ags. Thus far, the potential role of CD4(+)CD25(+) T cells in human tumors has not been reported. In this work we show that lung tumors contain large numbers of these cells and that they have constitutive high-level expression of CD152 (CTLA-4). Furthermore, the CD4(+)CD25(+) T cells mediate potent inhibition of autologous T cell proliferation. Finally, regulatory T cells from patient tumors failed to inhibit the proliferation of allogeneic T cells. Together these results suggest that the CD4(+)CD25(+) T cells found in lung tumors selectively inhibit the host immune response and therefore could contribute to the progression of lung cancer.
Woo
Edward Y
EY
Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA.
Yeh
Heidi
H
Chu
Christina S
CS
Schlienger
Katia
K
Carroll
Richard G
RG
Riley
James L
JL
Kaiser
Larry R
LR
June
Carl H
CH
D000069594:Abatacept; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D060908:CTLA-4 Antigen; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology*; D002478:Cells, Cultured; D006801:Humans; D018796:Immunoconjugates; D008175:Lung Neoplasms / Q000276:immunology*; D008213:Lymphocyte Activation; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000032:analysis; D016212:Transforming Growth Factor beta / Q000502:physiology
D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D018796:Immunoconjugates; D015375:Receptors, Interleukin-2; D016212:Transforming Growth Factor beta; D000069594:Abatacept