title: Linkage mapping of sex-specific differences.
abstract: Most current linkage analyses assume identical fractions of meiotic recombination between homologous marker loci of the two sexes. This assumption is not realistic, because considerable sex-related differences have been observed in recombination fraction. In this paper, a general EM-based algorithm is presented to estimate sex-specific recombination fractions for a mixed set of molecular markers segregating differently in a full-sib family derived from two heterozygous parents. The asymptotic variances of the estimates of linkage specifically for each of the parents are evaluated using a numerical analysis based on information functions. This approach will have important implications for precise gene mapping based on sex-specific linkage maps.
authors.affiliation: Department of Statistics, University of Florida, Gainesville, FL 32611, USA. rwu@stat.ufl.edu
authors.forename: Rongling
authors.initials: R
authors.lastname: Wu
authors.forename: Chang-Xing
authors.initials: CX
authors.lastname: Ma
authors.forename: S S
authors.initials: SS
authors.lastname: Wu
authors.forename: Zhao-Bang
authors.initials: ZB
authors.lastname: Zeng
mesh_terms: D000465:Algorithms; D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D011995:Recombination, Genetic / Q000235:genetics*; D012727:Sex Characteristics
chemical_list: D005819:Genetic Markers