title: Molecular mechanisms of activated T cell death in vivo.
abstract: The culmination of the immune response involves the death of the majority of the activated antigen-specific T lymphocytes. The death of these cells is important to prevent autoimmunity, to decrease the metabolic cost to the organism and to ensure T cell homeostasis. This review will focus on the mechanisms that, in animals, control the death of these activated cells. At least two separate types of cell death can occur (activation-induced cell death and activated T cell autonomous death) via death receptors such as Fas or the Bcl-2 related protein Bim, respectively. Finally, adjuvants that enable T cell survival may operate via NF-kappaB and Bcl-3 rather than cytokines.
authors.affiliation: Howard Hughes Medical Institute, University of Colorado Health Sciences Center, Denver, CO 80206, USA. hildemand@njc.org
authors.forename: David A
authors.initials: DA
authors.lastname: Hildeman
authors.forename: Yanan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Mitchell
authors.forename: John
authors.initials: J
authors.lastname: Kappler
authors.forename: Philippa
authors.initials: P
authors.lastname: Marrack
mesh_terms: D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D006801:Humans; D008213:Lymphocyte Activation; D016328:NF-kappa B / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D016328:NF-kappa B; D019253:Proto-Oncogene Proteins c-bcl-2