Steele-Richardson-Olszewski-syndrome: the relation of dopamine D2 receptor binding and subcortical lesions in MRI.
We compared (123)I-iodobenzamide single photon emission computed tomography (IBZM-SPECT) for imaging of striatal dopamine D(2) receptors in vivo, and MRI in 32 patients with the clinical diagnosis of progressive supranuclear palsy (PSP). We found a significant inter-dependence of reduction of specific striatal IBZM binding indicative of striatal degeneration and of the absence of multiple signal hyperintensities in MRI; age had no influence neither on IBZM binding nor on signal hyperintensities. We conclude that the presence of multiple signal hyperintensities should raise doubt on the correct clinical diagnosis.
Arnold
G
G
Department of Neurology, Klinikum Gorsshadern, University of Munich, Federal Republic of Germany.
Schwarz
J
J
Tatsch
K
K
Kraft
E
E
Wächter
T
T
Bandmann
O
O
Oertel
W H
WH
D000368:Aged; D016001:Confidence Intervals; D003342:Corpus Striatum / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007462:Iodobenzenes / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D008636:Mesencephalon / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis* / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon / Q000706:statistics & numerical data
D007462:Iodobenzenes; D019275:Radiopharmaceuticals; D017448:Receptors, Dopamine D2; C426805:idobenzamide