title: Measurement of quality of life in head and neck cancer patients utilizing the quality of life radiation therapy questionnaire.
abstract: BACKGROUND
  Quality of life (QOL) measures give patients the possibility to express subjective changes in wellbeing. We aimed to translate the radiation specific quality of life questionnaire (QOL-RTI) and the companion head and neck module (H&N) questionnaire into German and to test its reliability, validity and sensitivity.
  
  
  METHODS
  After translation and final revisions based on qualitative interviews with ten patients, 97 head and neck cancer patients were screened for eligibility. Patients answered the 38 items questionnaire at baseline and twice in week 4 of radiotherapy for test-retest reliability. Internal consistency was calculated using Chronbach's alpha. Patients also completed the functional assessment of cancer tool plus head and neck (FACT-G plus H&N) for concurrent validity. Item analyses were performed to test the sensitivity.
  
  
  RESULTS
  Chronbach's alpha yielded alpha = 0.85 for the QOL-RTI and alpha = 0.80 for the H&N module, test-retest reliability scores were r = 0.87 and r = 0.83, respectively. The correlation of the QOL-RTI plus H&N and the FACT plus H&N was r = 0.79. Questionnaire sensitivity was supported by significant changes in the mean score of 45.8% of the QOL-RTI items and 78.6% of the H&N items between baseline and week 4 of radiotherapy.
  
  
  CONCLUSIONS
  The German version of the QOL-RTI was shown to be a reliable, valid and sensitive tool to assess the quality of life of patients undergoing radiotherapy. The H&N module is useful for patients undergoing treatment for head and neck cancer.
authors.affiliation: Department of Radiotherapy and Radiobiology, University Hospital Medical School of Vienna, Austria.
authors.forename: Monika
authors.initials: M
authors.lastname: Janda
authors.forename: Darlene
authors.initials: D
authors.lastname: Johnson
authors.forename: Hedwig
authors.initials: H
authors.lastname: Woelfl
authors.forename: Michael
authors.initials: M
authors.lastname: Trimmel
authors.forename: Tim
authors.initials: T
authors.lastname: Bressmann
authors.forename: Heidi
authors.initials: H
authors.lastname: Schröckmayr
authors.forename: Joachim
authors.initials: J
authors.lastname: Widder
authors.forename: Andy
authors.initials: A
authors.lastname: Trotti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001317:Austria; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010039:Otorhinolaryngologic Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D018434:Sickness Impact Profile