Novel regulation and function of Src tyrosine kinase.
Src tyrosine kinase is a critical signal transducer that modulates a wide variety of cellular functions. Misregulation of Src leads to cell transformation and cancer. Heterotrimeric guanine-nucleotide-binding proteins (G proteins) are another group of signaling molecules that transduce signals from cell-surface receptors to generate physiological responses. Recently, it was discovered that G alpha s and G alpha i could directly stimulate Src family tyrosine kinase activity. This novel regulation of Src tyrosine kinase by G proteins provides insights into the adenylyl cyclase-independent signaling mechanisms involved in ligand-induced receptor desensitization, internalization and other physiological processes.
Ma
Y C
YC
Department of Physiology, Weill Medical College of Cornell University, New York, NY 10021, USA.
Huang
X Y
XY
D000818:Animals; D066246:ErbB Receptors / Q000378:metabolism; D005786:Gene Expression Regulation; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics; D010766:Phosphorylation; D011487:Protein Conformation; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D019061:src-Family Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D011943:Receptors, Adrenergic, beta; D066246:ErbB Receptors; D019061:src-Family Kinases; D017027:Protein Tyrosine Phosphatases; D020962:Heterotrimeric GTP-Binding Proteins