Chemical synthesis and calcium release activity of N(1)-ether strand substituted cADPR mimic.
8-Chloro cyclic inosine 5'-diphosphate ethoxymethyl ether 3 was synthesized by means of chemical method from protected inosine via phenylthio-type biphosphate substrate. The detection of Ca(2+) release activity shows that 3 is a potent agonist of cADPR and has activity in intact Hela cells.
Huang
Li-Jun
LJ
National Research Laboratory of Natural and Biomimetic Drugs, Peking University, 100083, Beijing, PR China.
Zhao
Yong-Yuan
YY
Yuan
Lan
L
Min
Ji-Mei
JM
Zhang
Li-He
LH
D002118:Calcium / Q000378:metabolism*; D036563:Cyclic ADP-Ribose / Q000819:agonists* / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D018716:Molecular Mimicry; D013329:Structure-Activity Relationship
D004987:Ethers; D036563:Cyclic ADP-Ribose; D002118:Calcium