Online genomics facilities in the new millennium.
The review begins by providing a brief typology of biological databases on the Internet, illustrated by examples of the most influential resources of each kind. We then take an insider look at one typical on-line genomic resource -- the yeast genome database hosted at the Munich Information Center for Protein Sequences (MIPS) -- and explain how and why it has evolved from a basic sequence repository to a multidomain knowledge base. The role of community efforts in curating and annotating genome data is discussed. The crucial role of data integration and interoperability in developing next-generation genomic facilities is underscored.
Frishman
Dmitrij
D
Institute for Bioinformatics, GSF - National Research Center for Environment and Heatlh, Ingolstädter Landstrasse 1, 85764 Neueherberg, Germany. d.frishman@gsf.de
Kaps
Andreas
A
Mewes
Hans-Werner
HW
D000818:Animals; D019295:Computational Biology / Q000379:methods / Q000639:trends*; D030541:Databases, Genetic / Q000639:trends*; D023281:Genomics / Q000379:methods / Q000639:trends*; D006801:Humans; D009862:Online Systems / Q000639:trends*