Treatment of murine cutaneous melanoma with near infrared light.
Treatment of cutaneous melanoma (M-3 and B16-F10 implanted in mice) with rapidly-scanned, tightly-focused near infrared light elicits selective destruction of tumor tissue. A single laser treatment yielded complete eradication in >90% of B16-F10 tumors with thicknesses of approximately 3 mm; amelanotic M-3 tumors proved less responsive (ca 25% clearance rate). In addition to local tumor destruction, laser treatment of B16-F10 tumors in immunocompetent mice stimulated enhanced cytokine levels (interleukin-2 and interleukin-10) within treated tumor tissues and rejection of tumor cells upon a subsequent challenge dose. Such an antitumor immune response may lead to improved outcomes at both the treatment site and at sites of distant metastasis.
Dees
C
C
Photongen, Inc., Knoxville, TN 37931, USA.
Harkins
J
J
Petersen
M G
MG
Fisher
W G
WG
Wachter
E A
EA
D000818:Animals; D005260:Female; D007259:Infrared Rays; D008546:Melanoma, Experimental / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy*