[Biological properties of clinical isolates of Mycobacterium tuberculosis].
The invasiveness of 2 grud sensitive and 8 holy-resistant M. tuberculosis clinical isolated was evaluated in experiments on BALB/c mice. Mycobacterial suspension was injected into the caudal vein of experimental animals. The results were evaluated by the degree of contamination of lungs and spleen of infected animals euthanized at different periods on time. The study revealed high variability in the degree of contamination of the organs of the animals infected with M. tuberculosis drug-resistant clinical isolates.
Shemiakin
I G
IG
State Research Center of Applied Microbiology, Obolensk, Moscow Region, Russia.
Stepanshina
V N
VN
Korobova
O V
OV
Ivanov
I Iu
IIu
Lazarev
A A
AA
Skaldina
A A
AA
Levacheva
V A
VA
D000818:Animals; D024881:Drug Resistance, Bacterial; D006801:Humans; D008168:Lung / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification / Q000472:pathogenicity*; D013154:Spleen / Q000382:microbiology; D014376:Tuberculosis / Q000382:microbiology* / Q000503:physiopathology; D014774:Virulence