title: Levels of C-reactive protein in pregnant women who subsequently develop pre-eclampsia.
abstract: OBJECTIVE
  To investigate whether a maternal inflammatory response precedes the development of preeclampsia.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Antenatal clinic in an inner city teaching hospital.
  
  
  METHODS
  Two groups of women were examined at 23-25 weeks of gestation. The first group (45 women) had normal uterine artery Doppler waveforms and subsequently had a normal pregnancy outcome. The second group (45 women) had Doppler evidence of impaired placental perfusion and 21 (47%) of them had normal outcome, 14 (31%) developed intrauterine growth restriction and 10 (22%) developed pre-eclampsia, with or without intrauterine growth restriction.
  
  
  METHODS
  C-reactive protein, an acute-phase reactant, was measured in maternal serum using a highly sensitive method with a detection limit of 0.05 mg/L.
  
  
  METHODS
  Development of pre-eclampsia, as defined by the International Society for the Study of Hypertension in Pregnancy. Intrauterine growth restriction was defined as birthweight <5th centile for gestation and sex of the neonate.
  
  
  RESULTS
  The serum C-reactive protein concentration in women who subsequently developed pre-eclampsia (median 1.56, range 0.55-3.12 mg/L) or delivered a baby with birthweight <5th centile (median 0.74, range 0.64-1.58 mg/L) was not significantly different from that in women with uncomplicated pregnancies (median 1.28, range 0.75-2.08 mg/L; P = 0.95 and P = 0.62, respectively).
  
  
  CONCLUSIONS
  These findings suggest that the onset of clinical signs of pre-eclampsia may not be preceded by a maternal inflammatory response, as assessed by measurement of C-reactive protein.
authors.affiliation: Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
authors.forename: Makrina D
authors.initials: MD
authors.lastname: Savvidou
authors.forename: Christoph C
authors.initials: CC
authors.lastname: Lees
authors.forename: Mauro
authors.initials: M
authors.lastname: Parra
authors.forename: Aroon D
authors.initials: AD
authors.lastname: Hingorani
authors.forename: Kypros H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D005317:Fetal Growth Retardation; D005865:Gestational Age; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000000981:diagnostic imaging; D011247:Pregnancy; D011256:Pregnancy Outcome; D014463:Ultrasonography
chemical_list: D002097:C-Reactive Protein