Dynamic multiphosphorylation passwords for activity-dependent gene expression.
Synapse-to-nucleus signaling leading to CREB-mediated transcription is important for neuronal plasticity. Nuclear CREB phosphorylation at Ser133 allows convergence of multiple kinase pathways driven by neuronal activity and links them to transcriptional activation. But, can various pathways share a common effector mechanism (phosphorylating Ser133) while generating distinct patterns of gene expression? We review three Neuron articles that highlight novel ways Ca(2+) signals can trigger multiple phosphorylation events working in combination to control CREB and its interaction with coactivator molecules.
Deisseroth
Karl
K
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. deissero@stanford.edu
Tsien
Richard W
RW
D000818:Animals; D001921:Brain / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D010766:Phosphorylation
D017362:Cyclic AMP Response Element-Binding Protein