title: Molecular dynamics simulations.
abstract: Molecular dynamics simulations have become a standard tool for the investigation of biomolecules. Simulations are performed of ever bigger systems using more realistic boundary conditions and better sampling due to longer sampling times. Recently, realistic simulations of systems as complex as transmembrane channels have become feasible. Simulations aid our understanding of biochemical processes and give a dynamic dimension to structural data; for example, the transformation of harmless prion protein into the disease-causing agent has been modeled.
authors.affiliation: Laboratory of Physical Chemistry, Swiss Federal Institute of Technology Zürich, ETH-Hönggerberg, 8093, Zürich, Switzerland.
authors.forename: Tomas
authors.initials: T
authors.lastname: Hansson
authors.forename: Chris
authors.initials: C
authors.lastname: Oostenbrink
authors.forename: WilfredF
authors.initials: W
authors.lastname: van Gunsteren
mesh_terms: D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D003198:Computer Simulation; D015195:Drug Design; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D007473:Ion Channels; D011506:Proteins