title: The genetic jigsaw of inflammatory bowel disease.
abstract: Following a prolonged period of relative inertia, real progress has been made in the past few years in understanding the pathogenesis of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis. Clinical experience, epidemiological studies, and molecular genetics have provided strong evidence that both genetic and environmental factors are important in disease pathogenesis, and gene-environmental interaction determines disease susceptibility and behaviour.
authors.affiliation: Gastrointestinal Unit, The University of Edinburgh, Western General Hospital, Edinburgh, UK. dwatts@ed.ac.uk
authors.forename: D A
authors.initials: DA
authors.lastname: Watts
authors.forename: J
authors.initials: J
authors.lastname: Satsangi
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D002881:Chromosomes, Human, Pair 12; D003093:Colitis, Ulcerative / Q000235:genetics / Q000628:therapy; D003424:Crohn Disease / Q000235:genetics / Q000628:therapy; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics* / Q000628:therapy; D000069285:Infliximab; D008957:Models, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D005819:Genetic Markers; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab