Dopamine effects on pulmonary artery pressure in hypotensive preterm infants with patent ductus arteriosus.
We investigated the effects of dopamine on pulmonary artery pressure in 18 ventilated hypotensive preterm neonates by using the flow characteristics of the ductal shunt. Dopamine has variable effects on pulmonary/systemic mean arterial pressure ratio with half the neonates showing an increase in pulmonary pressure relative to systemic pressure.
Liet
Jean-Michel
JM
Pediatric and Neonatal Critical Care Division, University Hospital of Nantes, France.
Boscher
Cécile
C
Gras-Leguen
Christèle
C
Gournay
Véronique
V
Debillon
Thierry
T
Rozé
Jean-Christophe
JC
D001794:Blood Pressure / Q000187:drug effects*; D004298:Dopamine / Q000494:pharmacology*; D004374:Ductus Arteriosus, Patent / Q000503:physiopathology*; D015150:Echocardiography, Doppler; D006439:Hemodynamics; D006801:Humans; D007022:Hypotension / Q000188:drug therapy* / Q000503:physiopathology; D007231:Infant, Newborn; D007234:Infant, Premature; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D014662:Vasoconstrictor Agents; D004298:Dopamine