Identification of a novel HLA-DPB1 allele, DPB1*02014, by sequence-based typing.
In this report we describe the identification of a novel DPB1 allele, DPB1*02014, found in an Italian Caucasian individual. The new allele was detected during routine HLA sequence-based typing (SBT) for an individual undergoing bone marrow transplantation. DPB1*02014 was identical to DPB1*02012 except for a single nucleotide substitution in codon 72 (GTG-->GTT). This nucleotide change represents a synonimous mutation, as both triplets code for a valine. This new allele has been submitted to GenBank and assigned the accession number AF326565. The WHO Nomenclature Committee has officially assigned the name DPB1*02014.
Curcio
M
M
Laboratory of Immunogenetics, Nephrology Unit, Ospedale S. Chiara, Italy.
Lapi
S
S
Italia
S
S
Rizzo
G
G
D001483:Base Sequence; D016026:Bone Marrow Transplantation; D017931:DNA Primers; D005802:Genes, MHC Class II; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006650:Histocompatibility Testing; D006801:Humans; D007558:Italy; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment; D044465:White People / Q000235:genetics
D017931:DNA Primers; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; C466442:HLA-DPB1*02:01:04 antigen