[Bactericidal activity of biapenem against various efflux system mutants of Pseudomonas aeruginosa].
The bactericidal activity of biapenem, a new carbapenem, against various efflux-mutants of Pseudomonas aeruginosa was compared with those of imipenem, panipenem, meropenem and ceftazidime. The bactericidal activity of biapenem against P. aeruginosa KG5001, a strain deficient in MexAB-OprM, MexCD-OprJ and MexXY-OprM, was very strong compared with those of imipenem and meropenem. In terms of bactericidal activities, biapenem and imipenem had similar activities against P. aeruginosa KG5003, a strain overexpressing MexAB-OprM, as against P. aeruginosa KG5001, however meropenem and ceftazidime had weaker activities against KG5003 than KG5001. The bactericidal activity against P. aeruginosa KG5007, a strain overexpressing MexCD-OprJ, was observed only by biapenem. The bactericidal activity of biapenem was strong and not influenced by all of these three efflux systems.
Hiraishi
Tooru
T
Pharmaceutical Research Center, Meiji Seika Kaisha, LTD. 760 Morooka-cho, Kohoku-ku, Yokohama, Kanagawa, 222-8567, Japan.
Miyata
Aiko
A
Takata
Toshihiko
T
Araake
Minako
M
Ogawa
Hiroshi
H
Gotoh
Naomasa
N
Nishino
Takeshi
T
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D015378:Imipenem / Q000494:pharmacology; D000077731:Meropenem; D009154:Mutation; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics*; D013845:Thienamycins / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D013845:Thienamycins; D015378:Imipenem; D002442:Ceftazidime; D000077731:Meropenem; C039536:panipenem; C065257:biapenem