title: Influence of progressive renal dysfunction in chronic heart failure.
abstract: Chronic heart failure (CHF) is often associated with impaired renal function due to hypoperfusion. Such patients are very sensitive to changes in renal perfusion pressure, and may develop acute tubular necrosis if the pressure falls too far. The situation is complicated by the use of diuretics, ACE inhibitors and spironolactone, all of which may affect renal function and potassium balance. Chronic renal failure (CRF) may also be associated with fluid overload. Anaemia and hypertension in CRF contribute to the development of left ventricular hypertrophy (LVH), which carries a poor prognosis, so correction of these factors is important.
authors.affiliation: Regional Nephrology Unit, Belfast City Hospital, Northern Ireland, Belfast, UK.
authors.forename: A Peter
authors.initials: AP
authors.lastname: Maxwell
authors.forename: Hean Y
authors.initials: HY
authors.lastname: Ong
authors.forename: D Paul
authors.initials: DP
authors.lastname: Nicholls
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology; D002908:Chronic Disease; D004232:Diuretics / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006333:Heart Failure / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D013318:Stroke Volume / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004232:Diuretics