title: Significance of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) for detection of renal cell carcinoma and immunohistochemical glucose transporter 1 (GLUT-1) expression in the cancer.
abstract: OBJECTIVE
  Positron emission tomography (PET) is now primarily used in oncological indication owing to the successful application of fluorine-18 fluorodeoxyglucose (FDG) in an increasing number of clinical indications. Glucose transporter 1 (GLUT-1) is recognized as a major early marker of cellular malignant transformation. The aims of this study were to assess whether FDG-PET is a useful diagnostic tool for renal cell carcinoma and to compare the pathologic characteristics.
  
  
  METHODS
  Nineteen consecutive patients who had renal cell carcinoma were examined using FDG-PET preoperatively. The results of PET were then compared to the histology obtained after radical surgery and the immunoreactivity of GLUT-1 was also studied.
  
  
  RESULTS
  Pathologic examination confirmed that all 19 patients suffered from renal cell carcinoma. Increased FDG uptake was found in six of the 19 patients (31.5%). The immunohistochemical examination of GLUT-1 in renal cell carcinoma produced different results in each patient. There was no correlation with GLUT-1 immunoreactivity and FDG-PET positivity.
  
  
  CONCLUSIONS
  These results suggest that FDG-PET may not be a useful diagnostic tool for renal cell carcinoma.
authors.affiliation: Department of Urology, Tokai University School of Medicine, Kanagawa, Japan. miyakita@is.icc.u-tokai.ac.jp
authors.forename: Hideshi
authors.initials: H
authors.lastname: Miyakita
authors.forename: Masatosi
authors.initials: M
authors.lastname: Tokunaga
authors.forename: Hajime
authors.initials: H
authors.lastname: Onda
authors.forename: Yukio
authors.initials: Y
authors.lastname: Usui
authors.forename: Hidechika
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kawamura
authors.forename: Seiei
authors.initials: S
authors.lastname: Yasuda
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009004:Monosaccharide Transport Proteins / Q000032:analysis / Q000096:biosynthesis*; D014055:Tomography, Emission-Computed
chemical_list: D009004:Monosaccharide Transport Proteins