title: Intestinal and hepatic response to combined partial hepatectomy and small bowel resection in mice.
abstract: BACKGROUND
  Both partial-hepatectomy (PHx) and massive small bowel resection (SBR) are strong mitogenic signals to the remnant liver and intestine, respectively. This study tested the hypothesis that PHx was an additive signal for intestinal adaptation after massive SBR.
  
  
  METHODS
  Male mice underwent either sham SBR or 50% proximal SBR. Mice from these two groups were then subjected to a 70% PHx or sham PHx. After 3 days, parameters of intestinal adaptation and liver regeneration were recorded in the remnant intestine and liver, respectively.
  
  
  RESULTS
  Intestinal adaptation following SBR occurred normally, but was not enhanced after concomitant PHx. On the other hand, SBR impaired the regenerative ability of the liver following PHx.
  
  
  CONCLUSIONS
  Intestinal adaptation after SBR takes priority over liver regeneration after PHx. These data implicate a hierarchy with regard to adaptive alterations to organ loss and endorse an important role for the intestinal mucosa in the regulation of hepatic regeneration.
authors.affiliation: Division of Pediatric Surgery, Children's Hospital Medical Center, Department of Surgery, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.
authors.forename: Lindsey A
authors.initials: LA
authors.lastname: Nelson
authors.forename: David P
authors.initials: DP
authors.lastname: O'Brien
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Kemp
authors.forename: Jodi L
authors.initials: JL
authors.lastname: Williams
authors.forename: Erik
authors.initials: E
authors.lastname: Dunke-Jacobs
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Erwin
authors.forename: Brad W
authors.initials: BW
authors.lastname: Warner
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D015153:Blotting, Western; D006498:Hepatectomy / Q000379:methods; D007421:Intestine, Small / Q000502:physiology* / Q000601:surgery*; D008099:Liver / Q000166:cytology / Q000473:pathology / Q000502:physiology; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D023421:Models, Animal; D009929:Organ Size; D018809:Proliferating Cell Nuclear Antigen / Q000502:physiology
chemical_list: D018809:Proliferating Cell Nuclear Antigen