T-cell responses in allergy and asthma.
T-helper-2-type cytokines and some chemokines play an essential role in the pathogenesis of both allergy and asthma. A change in the T-helper 1/T-helper 2 balance, caused by the dramatic change in the microbial environment of children, may account for the increasing prevalence of these conditions, but can also provide a conceptual basis for the development of new therapeutic strategies.
Romagnani
S
S
Section of Clinical Immunology, Allergy, and Respiratory Diseases, Department of Internal Medicine, University of Florence, Florence, Italy. s.romagnani@mednuc2.dfc.unifi.it
D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000628:therapy; D018925:Chemokines / Q000502:physiology; D004777:Environment; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology*; D018418:Th2 Cells / Q000502:physiology
D018925:Chemokines