Neonatal alloimmune thrombocytopenia with significant HLA antibodies.
A case of neonatal alloimmune thrombocytopenia (NAIT) secondary to human platelet antigen (HPA)-1a antibodies is reported. Additional multispecific HLA antibodies rendered volunteer donor platelet transfusions ineffective. Despite a high incidence of maternal HLA antibodies in the pregnant population, there is only one previous report of clinically significant HLA antibodies.
Grainger
J D
JD
Department of Haematology, Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK. igrainger@bigfoot.com
Morrell
G
G
Yates
J
J
Deleacy
D
D
D000906:Antibodies / Q000276:immunology*; D016824:Antigens, Human Platelet / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D039661:Integrin beta3; D017713:Platelet Transfusion / Q000379:methods; D013921:Thrombocytopenia / Q000276:immunology* / Q000628:therapy
D000906:Antibodies; D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3