title: Managing neural tissue injury in combined vertebral column-spinal cord injury.
abstract: Orthopaedic, neurosurgical, and trauma nurses all care for patients who have sustained a spinal cord injury (SCI) and are challenged to address care issues related to spinal stability as well as neurologic function. Advances in the understanding of the pathobiology of SCI have given rise to a three-tiered, time-sensitive approach to intervention designed to optimize functional recovery. Immediately after injury, pharmacologic strategies dominate. They are generally intended to limit progression of the initial injury, preserve existing neurologic function, and create the nidus for future regeneration. This article reviews the current standard of care with respect to hyperacute neuroprotection after blunt SCI in adults. After a synopsis of selected concepts in the pathophysiology of injury and pharmacology, clinical trial results will be presented, followed by a discussion of the nursing implications associated with the use of high-dose methylprednisolone neuroprotective therapy.
authors.affiliation: St. Michael's Hospital, Toronto, Ontario.
authors.forename: Milena
authors.initials: M
authors.lastname: Segatore
mesh_terms: D004496:Education, Continuing; D006801:Humans; D009434:Neural Pathways / Q000187:drug effects / Q000293:injuries*; D016530:Orthopedic Nursing / Q000592:standards; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000534:rehabilitation; D013131:Spine / Q000503:physiopathology