title: Cross-linked collagen C- and N-telopeptides for an early diagnosis of bone metastasis from breast cancer.
abstract: Bone resorption markers have become available for the diagnosis of bone metastasis. We evaluated cross-linked collagen C-and N-telopeptides (ICTP and NTx) in diagnosing bone metastasis from breast cancer. For a threshold of 4.5 ng/ml of 1CTP and 55.0 pmol BCE/micromol of NTx, bone metastasis could be predicted with an accuracy of 84% and 63%, respectively. All the patients who had metastatic lesions, but showed lower than 4.5 ng/ml of ICTP, had a solitary lesion of bone metastasis. Although ICTP is not sensitive enough to detect an early stage of bone metastasis, it is a better biochemical marker than NTx for detecting bone metastasis from breast cancer.
authors.affiliation: Second Department of Surgery, Yokohama City University, Yokohama 236-0004, Japan.
authors.forename: Konosuke
authors.initials: K
authors.lastname: Kiuchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Yohei
authors.initials: Y
authors.lastname: Hamaguchi
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Momiyama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Akira
authors.initials: A
authors.lastname: Ishiyama
authors.forename: Toshiro
authors.initials: T
authors.lastname: Kono
authors.forename: Takako
authors.initials: T
authors.lastname: Doi
authors.forename: Takashi
authors.initials: T
authors.lastname: Chishima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimada
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology*; D003094:Collagen / Q000096:biosynthesis* / Q000737:chemistry*; D024042:Collagen Type I; D003432:Cross-Linking Reagents / Q000494:pharmacology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000737:chemistry*; D011347:Procollagen / Q000097:blood*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D024042:Collagen Type I; D003432:Cross-Linking Reagents; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; D003094:Collagen