Homeostatic expansion versus antigen-driven proliferation: common ends by different means?
The requirements for T-cell proliferation driven by "space-filling" (homeostatic expansion) differ significantly from those for antigen-driven responses. Here we review these differences and discuss their implications for regulation of T-cell responses and the size of the T-cell compartment.
Prlic
Martin
M
Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, MMC 334, 420 Delaware St SE, Minneapolis, MN 55455, USA.
Jameson
Stephen C
SC
D000818:Animals; D000941:Antigens / Q000276:immunology*; D002455:Cell Division; D016207:Cytokines / Q000276:immunology; D006649:Histocompatibility Antigens / Q000276:immunology; D006706:Homeostasis; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D008231:Lymphopenia / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*
D000941:Antigens; D016207:Cytokines; D006649:Histocompatibility Antigens