Decoding the patterns of self and nonself by the innate immune system.
The innate immune system evolved several strategies of self/nonself discrimination that are based on the recognition of molecular patterns demarcating infectious nonself, as well as normal and abnormal self. These patterns are deciphered by receptors that either induce or inhibit an immune response, depending on the meaning of these signals.
Medzhitov
Ruslan
R
Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. ruslan.medzhitov@yale.edu
Janeway
Charles A
CA
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D017209:Apoptosis; D005075:Biological Evolution; D003170:Complement Pathway, Alternative; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation; D007694:Killer Cells, Natural / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D009336:Necrosis; D010457:Peptidoglycan / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology; D017634:Self Tolerance; D012794:Sialic Acids / Q000378:metabolism
D015703:Antigens, CD; D015395:Histocompatibility Antigens Class I; D008070:Lipopolysaccharides; D010457:Peptidoglycan; D011971:Receptors, Immunologic; D012794:Sialic Acids