title: Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors.
abstract: Benzimidazoles and their isosteric compounds as factor Xa inhibitors are discussed.
authors.affiliation: Department of Chemistry, Aventis Pharmaceuticals, Route 202-206, Bridgewater, NJ 08807, USA. whe@prius.jnj.com
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Barbara
authors.initials: B
authors.lastname: Hanney
authors.forename: Michael R
authors.initials: MR
authors.lastname: Myers
authors.forename: Stephen
authors.initials: S
authors.lastname: Condon
authors.forename: Michael R
authors.initials: MR
authors.lastname: Becker
authors.forename: Alfred P
authors.initials: AP
authors.lastname: Spada
authors.forename: Christopher
authors.initials: C
authors.lastname: Burns
authors.forename: Karen
authors.initials: K
authors.lastname: Brown
authors.forename: Dennis
authors.initials: D
authors.lastname: Colussi
authors.forename: Valeria
authors.initials: V
authors.lastname: Chu
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D015951:Factor Xa / Q000378:metabolism; D065427:Factor Xa Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D013329:Structure-Activity Relationship
chemical_list: D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D065427:Factor Xa Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings; D015951:Factor Xa