Serotonergic functioning in children with oppositional defiant disorder: a sumatriptan challenge study.
BACKGROUND
Several studies support the notion that disturbances in the central serotonergic function are related to impulsive aggression. There is recent evidence from studies on 5-HT(1B) knock-out mice that this specific receptor is involved in impulsive aggressive behavior. The aim of the present study was to investigate 5-HT(1B/1D) receptor functioning in normal intelligent hospitalized children with oppositional defiant disorder (ODD).


METHODS
The growth hormone (GH) response to a challenge with the 5-HT(1B/1D) agonist sumatriptan was examined in 20 children with an ODD, of whom 13 had an attention-deficit/hyperactivity disorder comorbidity, and 15 normal control subjects (NC). Blood samples for growth hormone were collected repeatedly between 8:30 and 12:00 AM. Sumatriptan was administered at 10 AM. The effect of stress due to this procedure was assessed by measuring salivary cortisol.


RESULTS
The GH response was significantly stronger in the children with ODD. After sumatriptan injection NC children showed a significant increase in cortisol; no such pattern was present in the ODD group.


CONCLUSIONS
The results suggest that the postsynaptic 5-HT(1B/1D) receptor is functionally more sensitive in children with ODD.
Snoek
Heddeke
H
Department of Child and Adolescent Psychiatry, B01-201, University Medical Center Utrecht, PO Box 85500, Utrecht 3508 GA, The Netherlands.
van Goozen
Stephanie H M
SH
Matthys
Walter
W
Sigling
Hein O
HO
Koppeschaar
Hans P F
HP
Westenberg
Herman G M
HG
van Engeland
Herman
H
D000374:Aggression / Q000187:drug effects; D000704:Analysis of Variance; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000188:drug therapy* / Q000503:physiopathology*; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006760:Hospitalization; D006801:Humans; D007175:Impulsive Behavior / Q000628:therapy; D008297:Male; D011985:Receptors, Serotonin / Q000097:blood* / Q000502:physiology; D012701:Serotonin / Q000097:blood* / Q000502:physiology; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*; D018170:Sumatriptan / Q000627:therapeutic use*
D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D012701:Serotonin; D018170:Sumatriptan; D013006:Growth Hormone