title: Determination of regional blood volume and intra-extracapillary water exchange in human myocardium using Feruglose: First clinical results in patients with coronary artery disease.
abstract: The aim of this pilot study in humans was to investigate the effect of an intravascular contrast agent (CA) on relaxation rate in myocardium (R(1,myo)) in the steady state. The dependence of R(1,myo) on R(1,blood) was characterized and compared with a theoretical model which allowed determination of the intra- extracapillary water proton exchange frequency (f = 0.48 s(-1)) and the intracapillary blood volume (RBV = 12.9 %). A linear response range of DeltaR(1,myo) on DeltaR(1,blood) was estimated which in future studies will allow the determination of RBV with intravascular CA.
authors.affiliation: Department of Cardiology, University of Wuerzburg, Wuerzburg, Germany. c.wacker@medizin.uni-wuerzburg.de
authors.forename: Christian M
authors.initials: CM
authors.lastname: Wacker
authors.forename: Frank
authors.initials: F
authors.lastname: Wiesmann
authors.forename: Michael
authors.initials: M
authors.lastname: Bock
authors.forename: Peter
authors.initials: P
authors.lastname: Jakob
authors.forename: Jörn J W
authors.initials: JJ
authors.lastname: Sandstede
authors.forename: Anja
authors.initials: A
authors.lastname: Lehning
authors.forename: Georg
authors.initials: G
authors.lastname: Ertl
authors.forename: Lothar R
authors.initials: LR
authors.lastname: Schad
authors.forename: Axel
authors.initials: A
authors.lastname: Haase
authors.forename: Wolfgang R
authors.initials: WR
authors.lastname: Bauer
mesh_terms: D000368:Aged; D002196:Capillaries / Q000502:physiology*; D003287:Contrast Media; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000378:metabolism* / Q000503:physiopathology*; D003911:Dextrans; D005260:Female; D052203:Ferrosoferric Oxide; D006801:Humans; D007501:Iron; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010087:Oxides; D012039:Regional Blood Flow / Q000502:physiology; D014867:Water / Q000378:metabolism
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D014867:Water; D007501:Iron; D052203:Ferrosoferric Oxide