Is high-sensitivity C-reactive protein an effective screening test for cardiovascular risk?
We evaluate the suggestion that high-sensitivity C-reactive protein testing be used for risk assessment in the primary prevention of cardiovascular disease, using the criteria proposed by the Guide to Clinical Preventive Services developed by the US Preventive Services Task Force. We conclude that at present, none of the 3 major criteria--accuracy, reliability, and likelihood of beneficial intervention--are satisfied.
Kushner
Irving
I
Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA. Ikushner@metrohealth.org
Sehgal
Ashwini R
AR
D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control*; D006801:Humans; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity
D002097:C-Reactive Protein