title: Clinical overview of leukocyte adhesion and migration: where are we now?
abstract: This article discusses the potential for clinical translation of the large amount of information on the molecular basis of leukocyte-endothelial cell interactions that has been collected over the last twenty years. Areas of current interest include the identification of adhesion molecule expression in inflammation by diagnostic imaging, understanding variability in inflammatory responsiveness and disease susceptibility through identification of adhesion molecule and chemokine polymorphisms and the application to the treatment of inflammatory diseases of monoclonal antibodies and conventional drugs with specific actions on leukocyte adhesion and migration.
authors.affiliation: BHF Cardiovascular Medicine Unit, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK.
authors.forename: Diane
authors.initials: D
authors.lastname: Marshall
authors.forename: Dorian O
authors.initials: DO
authors.lastname: Haskard
mesh_terms: D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology; D002465:Cell Movement; D018925:Chemokines / Q000502:physiology; D002634:Chemotaxis, Leukocyte; D019040:E-Selectin / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000235:genetics / Q000276:immunology; D007962:Leukocytes / Q000276:immunology* / Q000502:physiology*; D008024:Ligands; D019007:P-Selectin / Q000502:physiology; D019707:Receptors, Chemokine / Q000502:physiology
chemical_list: D015815:Cell Adhesion Molecules; D018925:Chemokines; D019040:E-Selectin; D016023:Integrins; D008024:Ligands; D019007:P-Selectin; D019707:Receptors, Chemokine