Contributions of Myc to tumorigenesis.
Despite intensive research, the mechanisms by which deregulation of myc gene expression contributes to tumorigenesis are still not fully resolved and many aspects are still enigmatic. Several recent reviews, including one published in this series a few months ago, have summarized recent progress in our understanding of the biochemistry of Myc proteins [Eisenmann, Genes Dev. (2001) in press; Amati et al., Biochim. Biophys. Acta 1471 (2001) 135-145]. Also, the evidence documenting a central role of Myc proteins in human tumorigenesis has been extensively reviewed [Henriksson and Lüscher, Cancer Res. 68 (1996) 109-182]. In this article, we will argue that current progress allows us to present testable hypotheses on how Myc affects specific properties of transformed cells.
Lutz
Werner
W
Institute for Molecular Biology and Tumor Research, University of Marburg, IMT, Mannkopff Str. 2, 35033, Marburg, Germany.
Leon
Javier
J
Eilers
Martin
M
D000818:Animals; D018797:Cell Cycle Proteins; D002455:Cell Division; D002460:Cell Line; D016922:Cellular Senescence; D019927:Cyclin E / Q000378:metabolism; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D015972:Gene Expression Regulation, Neoplastic; D016259:Genes, myc; D016678:Genome; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D018797:Cell Cycle Proteins; D019927:Cyclin E; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors