title: Significance of P-glycoprotein expression in childhood malignant tumors.
abstract: Resistance to chemotherapy significantly affects the treatment results in various cancers. Multidrug resistance caused by P-glycoprotein expression is now widely studied in human malignancies. We present the results of P-glycoprotein expression examination in 91 tumor tissue samples obtained from children treated for different malignant tumors in the Dept. of Pediatric Oncology, Prague. The correlation between the level of P-glycoprotein expression and tumor histology, clinical outcome, use of therapy, relapse rate and metastatic disease was made. P-glycoprotein expression was found significantly more frequent in soft tissue sarcomas, neuroblastomas, and hepatoblastomas, and generally in disseminated disease. On the contrary, a high expression of P-glycoprotein was not found in malignant brain tumors and nephroblastomas. The data strongly support the possibility that the percentage of P-glycoprotein expressing cells in selected tumors (soft tissue sarcomas, neuroblastomas), may have a clinical importance.
authors.affiliation: Department of Pediatric Oncology, 2nd Medical Faculty Charles University and University Hospital Motol, Prague, Czech Republic.
authors.forename: H
authors.initials: H
authors.lastname: Kucerová
authors.forename: D
authors.initials: D
authors.lastname: Sumerauer
authors.forename: E
authors.initials: E
authors.lastname: Drahokoupilová
authors.forename: M
authors.initials: M
authors.lastname: Pisková
authors.forename: J
authors.initials: J
authors.lastname: Bedrnícek
authors.forename: T
authors.initials: T
authors.lastname: Eckschlager
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D002648:Child; D002675:Child, Preschool; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D009369:Neoplasms / Q000378:metabolism*; D012008:Recurrence; D012983:Soft Tissue Neoplasms / Q000378:metabolism
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000911:Antibodies, Monoclonal