title: Expression of intercellular adhesion molecule-1 and prognosis in colorectal cancer.
abstract: Intercellular adhesion molecule-1 (ICAM-1) is a 90-kDa cell surface glycoprotein and is known to be a member of the immunoglobulin gene superfamily of adhesion molecules. It has been suggested that ICAM-1 expression on cancer cells might have a role as a suppressor of tumor progression under the host immune surveillance system. We studied the correlation between the expression of ICAM-1 and clinicopathological factors, as well as infiltration of tumor infiltrating lymphocytes (TILs) in colorectal cancer. Resected specimens from 96 patients with colorectal carcinoma were investigated using immunohistochemical staining with a monoclonal antibody against ICAM-1. As a result, the incidence of lymph node or liver metastasis was significantly lower in patients with ICAM-1-positive tumors than in those with ICAM-1-negative tumors. Infiltration of TILs was more frequently observed in the ICAM-1-positive tumors than in the ICAM-1-negative tumors. The prognosis of the patients with ICAM-1-negative tumors was significantly poorer than that of those with ICAM-1-positive tumors. In conclusion, these findings suggested that ICAM-1 expression is closely associated with metastasis and may be a useful indicator of prognosis in patients with colorectal cancer.
authors.affiliation: Department of Surgical Oncology (First Department of Surgery), Osaka City University Medical School, Japan. m1378386@med.osaka-cu.ac.jp
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Maeda
authors.forename: Soon-Myoung
authors.initials: SM
authors.lastname: Kang
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Sawada
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nishiguchi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yashiro
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Masaichi
authors.initials: M
authors.lastname: Ohira
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa-YS Chung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D016246:Lymphocytes, Tumor-Infiltrating / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D013997:Time Factors
chemical_list: D018799:Intercellular Adhesion Molecule-1