title: Comparison of methods used for recovering the line origin of alleles in a cross between outbred lines.
abstract: Here, we introduce the idea of probabilities of line origins for alleles in general pedigrees as found in crosses between outbred lines. We also present software for calculating these probabilities. The proposed algorithm is based on the linear regression method of Haley, Knott and Elsen (1994) combined with the Markov chain Monte Carlo (MCMC) method for estimating quantitative trait locus coefficients used as regressors. We compared the relative precision of our method and the original method as proposed by Haley et al. (1994). The scenarios studied varied in the allelic distribution of marker alleles in parental lines and in the frequency of missing marker genotypes. We found that the MCMC method achieves a higher accuracy in all scenarios considered. The benefits of using MCMC approximation are substantial if the frequency of missing marker data is high or the number of marker alleles is low and the allelic frequency distribution is similar in both parental lines.
authors.affiliation: Institute of Cytology and Genetics SB RAS, 630090 Novosibirsk, Russia.
authors.forename: Y S
authors.initials: YS
authors.lastname: Aulchenko
authors.forename: F
authors.initials: F
authors.lastname: Teuscher
authors.forename: H H
authors.initials: HH
authors.lastname: Swalve
authors.forename: V
authors.initials: V
authors.lastname: Guiard
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains / Q000235:genetics*; D003198:Computer Simulation; D003433:Crosses, Genetic; D005819:Genetic Markers; D008390:Markov Chains; D009010:Monte Carlo Method; D019655:Quantitative Trait, Heritable
chemical_list: D005819:Genetic Markers