Automated parallel solid-phase synthesis of non-peptide CCR1 receptor antagonists.
An automated, parallel, solid-phase synthesis and screening strategy using commercially available aryl acetic acids as starting materials has discovered novel, non-peptide CCR1 antagonists (K(i) < 100 nM).
Buckman
Brad O
BO
Berlex Biosciences, 15049 San Pablo Ave, Richmond, CA 94804, USA.
Ghannam
Ameen
A
Angela
Li
L
Liang
Meina
M
Mohan
Raju
R
Ng
Howard P
HP
D000085:Acetates / Q000138:chemical synthesis / Q000737:chemistry; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy; D054389:Receptors, CCR1; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D000085:Acetates; D000893:Anti-Inflammatory Agents; D054389:Receptors, CCR1; D019707:Receptors, Chemokine