title: [Genetic aspects of epilepsy: current knowledge and perspectives].
abstract: Rapidly advancing knowledge concerning the genetic aspects of epilepsy have led us to complete a recent article on the subject published in the journal. A contrasting picture is emerging, particularly between symptomatic and idiopathic epilepsy. For symptomatic epilepsy, divers gene products implicated in brain development and neuron survival have been identified. Inversely, for idiopathic epilepsy, the latest discoveries confirm their canalopathic nature. In addition, rapid progress in the field of mendelian inherited epilepsy has pointed out the lack of notable progress concerning common epilepsy with a complex hereditary pattern. These forms are one of the major challenges for genetic analysis of epilepsy.
authors.affiliation: Division de Neuropsychiatrie, Hôpitaux Universitaires de Genève, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Malafosse
authors.forename: B
authors.initials: B
authors.lastname: Moulard
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology; D004195:Disease Models, Animal; D004827:Epilepsy / Q000145:classification / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D005799:Genes, Dominant; D005808:Genes, Recessive; D018740:Genetic Heterogeneity; D006801:Humans; D007473:Ion Channels / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D051379:Mice; D008818:Mice, Neurologic Mutants; D023421:Models, Animal; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D011110:Polymorphism, Genetic; D013577:Syndrome
chemical_list: D007473:Ion Channels; D009419:Nerve Tissue Proteins