title: How do primary care physicians use long-term acid suppressant drugs? A population-based analysis of Dutch general practices.
abstract: OBJECTIVE
  A considerable proportion of the medication budget of Dutch general practitioners is spent on prescribed long-term acid suppressant drugs. We investigated the magnitude of long-term prescription of acid suppressant drugs in general practice and the frequency and means of confirming the primary working diagnosis.
  
  
  METHODS
  We used a retrospective descriptive study of 24 general practices in the Amsterdam region.
  
  
  METHODS
  We identified those receiving long-term acid suppressant therapy (12 or more weeks/year) from a total of 46,813 patients by extracting data from pharmacy databases.
  
  
  METHODS
  We measured the amount and duration of prescriptions for each medication, indications for prescription, and investigations performed by general practitioners.
  
  
  RESULTS
  Of the 46,813 patients, 922 (2%) received long-term acid suppressant therapy. The duration of prescription varied from 12 weeks in 8% of patients to &gt 52 weeks in 23% of patients (mean = 33 weeks). In 25% of patients, no investigations were performed; 75% of patients underwent endoscopy or ingested a barium meal. The predominant diagnoses in investigated patients were ulcer disease (39%), gastroesophageal reflux disease (49%), and functional dyspepsia (gastritis, normal aspect; 18%). Helicobacter pylori status was available in 29% of patients with ulcer disease. Eradication therapy was reported in 44% of these patients.
  
  
  CONCLUSIONS
  Among patients of physicians in general practice in the Amsterdam region, 2% used long-term acid suppressants. Patients with ulcer disease may stop taking acid suppressants after apparent successful H pylori eradication. Tapering strategies must be developed for patients with mild reflux disease or functional dyspepsia.
authors.affiliation: Dept of General Practice, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. g.j.hurenkamp@amc.uva.nl
authors.forename: G J B
authors.initials: GJ
authors.lastname: Hurenkamp
authors.forename: H G L M
authors.initials: HG
authors.lastname: Grundmeyer
authors.forename: P J E
authors.initials: PJ
authors.lastname: Bindels
authors.forename: G N J
authors.initials: GN
authors.lastname: Tytgat
authors.forename: R W M
authors.initials: RW
authors.lastname: Van Der Hulst
mesh_terms: D000293:Adolescent; D000328:Adult; D000863:Antacids / Q000627:therapeutic use*; D004363:Drug Utilization; D005194:Family Practice; D005260:Female; D005756:Gastritis / Q000175:diagnosis / Q000188:drug therapy; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D010437:Peptic Ulcer / Q000175:diagnosis / Q000188:drug therapy; D010818:Practice Patterns, Physicians'; D054328:Proton Pump Inhibitors; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D000863:Antacids; D054328:Proton Pump Inhibitors