title: Liquid-based cytology: is this the way forward for cervical screening?
abstract: Liquid-based cytology (LBC) is currently being marketed as an alternative methodology to replace the conventional PAP smear in cervical cytology. A substantial body of literature exists in support of LBC, some of which is at least partially sponsored by product manufacturers. The majority of published literature in support of LBC employs Bethesda reporting terminology. In this study we have analysed published raw data and presented this in NHSCSP terminology. Claims relating to sensitivity, specificity and smear adequacy have then been considered with reference to this data. Our analysis of existing data does not support the nationwide implementation of LBC at present. Further studies are recommended in order to evaluate the place of this technology within the NHSCSP.
authors.affiliation: The Pauline Cooper Department of Cytology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK. rpm21@hermes.cam.ac.uk
authors.forename: Robin P
authors.initials: RP
authors.lastname: Moseley
authors.forename: S
authors.initials: S
authors.lastname: Paget
mesh_terms: D003584:Cytological Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D016239:MEDLINE; D008403:Mass Screening; D065006:Papanicolaou Test; D012680:Sensitivity and Specificity; D009626:Terminology as Topic; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000517:prevention & control*; D014626:Vaginal Smears / Q000379:methods*