title: Megakaryocytes mimicking metastatic breast carcinoma.
abstract: False-positive diagnosis of lymph nodes occurs when a benign element in a lymph node, or in its capsule, is interpreted as metastatic carcinoma. This report describes a patient with breast carcinoma who had megakaryocytes in axillary sentinel lymph nodes mimicking metastatic carcinoma. The patient had no history of a hematologic disease, and we found no evidence of a concurrent hematopoietic disorder. The megakaryocytes were reactive for CD31, CD61, and von Willebrand factor, but not for cytokeratin (AE1/AE3). Megakaryocytes should be added to the list of benign histologic abnormalities that may simulate metastatic carcinoma in a sentinel lymph node.
authors.affiliation: Department of Pathology, Weill Medical College of Cornell University & New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY 10021, USA. sahoda@mail.cornell.edu
authors.forename: Syed A
authors.initials: SA
authors.lastname: Hoda
authors.forename: Erika
authors.initials: E
authors.lastname: Resetkova
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Yusuf
authors.forename: Anthony
authors.initials: A
authors.lastname: Cahan
authors.forename: Paul P
authors.initials: PP
authors.lastname: Rosen
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D000328:Adult; D000941:Antigens / Q000032:analysis; D015703:Antigens, CD / Q000032:analysis; D001706:Biopsy; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D039661:Integrin beta3; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008408:Mastectomy; D008533:Megakaryocytes / Q000737:chemistry / Q000473:pathology*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D010980:Platelet Membrane Glycoproteins / Q000032:analysis; D015203:Reproducibility of Results; D014841:von Willebrand Factor / Q000276:immunology
chemical_list: D000941:Antigens; D015703:Antigens, CD; D039661:Integrin beta3; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D010980:Platelet Membrane Glycoproteins; C029417:Von Willebrand antigen; D014841:von Willebrand Factor