Changes in rabbits' behaviour under the influence of corticotropin derivative analogue 4-10 in spontaneous conditions.
The influence and the role of corticotrophin analogue 4-10 on the rabbits' behaviour in spontaneous conditions was analysed. The data analysis indicated that analogue 4-10 with modified aminoacid sequence in 8, 9, 10 positions significantly influenced the behavioural changes in the general model of behaviour. The 4-10 corticotrophin derivative caused the suppression of aggression, considerably reduced the tension and orientation-cognition reactions, however, it prolonged comfort and grooming significantly. This may prove the noticeable reaction of analogue 4-10 in modification of behavioural pattern, which was expressed by restraining the reaction of stressogenic character with simultaneous attenuation and prolongation of appetite reactions.
Teter
M
M
Department of Human Physiology, Medical University of Lublin.
Dec-Szlichtyng
M
M
Cygan
B
B
Kozlovska
M M
MM
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects; D006120:Grooming / Q000187:drug effects; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011817:Rabbits
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10)