title: The tau H1 haplotype is associated with Parkinson's disease in the Norwegian population.
abstract: We investigated the association of Parkinson's disease (PD) with tau gene H1 haplotypes in the Norwegian population. In a sample of 96 unrelated PD cases and 68 control subjects, we observed an increased risk of PD for persons with the tau H1 haplotype (odds ratio=5.52; 95% confidence interval: 2.64-11.10; P=2.17x10(-6)). Findings provide evidence that tau participates in the PD pathogenic process and demonstrate the value of isolated populations in mapping complex traits.
authors.affiliation: Laboratory of Familial Movement Disorders, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: Matt
authors.initials: M
authors.lastname: Farrer
authors.forename: Lisa
authors.initials: L
authors.lastname: Skipper
authors.forename: Marianne
authors.initials: M
authors.lastname: Berg
authors.forename: Gina
authors.initials: G
authors.lastname: Bisceglio
authors.forename: Melissa
authors.initials: M
authors.lastname: Hanson
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.forename: Amanda
authors.initials: A
authors.lastname: Adam
authors.forename: Katrina
authors.initials: K
authors.lastname: Gwinn-Hardy
authors.forename: Jan
authors.initials: J
authors.lastname: Aasly
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016001:Confidence Intervals; D005260:Female; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D016017:Odds Ratio; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D016875:tau Proteins / Q000235:genetics*
chemical_list: D016875:tau Proteins