[A clinicopathologic study of nonspecific interstitial pneumonia].
OBJECTIVE
To investigate the clinicopathologic features of nonspecific interstitial pneumonia (NSIP).


METHODS
The clinical and pathological data of 8 cases with NSIP confirmed by open or video-assisted thoracoscopic lung biopsy were reviewed retrospectively.


RESULTS
NSIP occurred more in female (male:female 1:3, 2/6), and the patients' average age was 48 years. The clinical manifestation was progressive dyspnea, cough and sputum, crackles over both lungs and restrictive ventilating abnormalities. Reticular changes and patchy ground-glass attenuation in lower lung fields were the main findings on high resolution computed tomography. The pathological characteristic was uniform interstitial inflammation and fibrosis. Three cases showed fibroblast foci, was BOOP like changes in 4 and honeycombing in 1 case. of the 8 patients, 6 had cellular and fibrosing patterns; 2 had fibrosing patterns only; the former showed better response to glucocorticoid therapy than the latter.


CONCLUSIONS
The histologic patterns of NSIP correlated closely with the therapeutic effect of glucocorticoids. It is difficult to differentiate pathologically the fibrosing pattern of NSIP from usual interstitial pneumonia, therefore clinical data are indispensable in the diagnosis.
Yi
Xianghua
X
Department of Pathology, Shanghai Pulmonary Hospital, Shanghai 200433, China.
He
Guojun
G
Zheng
Di
D
Li
Huiping
H
Jiang
Gening
G
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology*; D017563:Lung Diseases, Interstitial / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013906:Thoracoscopy / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
D005938:Glucocorticoids