Protein kinase D: an intracellular traffic regulator on the move.
Recent research has identified protein kinase D (PKD, also called PKCmu) as a serine/threonine kinase with potentially important roles in growth factor signaling as well as in stress-induced signaling. Moreover, PKD has emerged as an important regulator of plasma membrane enzymes and receptors, in some cases mediating cross-talk between different signaling systems. The recent discovery of two additional kinases belonging to the PKD family and the plethora of proteins that interact with PKD point to a multifaceted regulation and a multifunctional role for these enzymes, with functions in processes as diverse as cell proliferation, apoptosis, immune cell regulation, tumor cell invasion and regulation of Golgi vesicle fission.
Van Lint
Johan
J
Division of Biochemistry, Faculty of Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000, Leuven, Belgium. Johan.Vanlint@med.kuleuven.ac.be
Rykx
An
A
Maeda
Yusuke
Y
Vantus
Tibor
T
Sturany
Sabine
S
Malhotra
Vivek
V
Vandenheede
Jackie R
JR
Seufferlein
Thomas
T
D000818:Animals; D006801:Humans; D011493:Protein Kinase C / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D020239:Receptor Cross-Talk; D015290:Second Messenger Systems / Q000502:physiology*
C089212:protein kinase D; D017346:Protein Serine-Threonine Kinases; D011493:Protein Kinase C