[A transient increase in CCK mRNA levels in amygdala following audiogenic seizures in audiogenic seizure-prone rats].
The effects of single and multiple seizures on cholecystokinin (CCK) mRNA levels in amygdala of audiogenic seizure-prone rats (P77PMC) were examined by in situ hybridization. The main results are as follows: (1) CCK mRNA positive neurons (No/0.01 mm(2)) in amygdala showed a transient increase in number from the 8+/-1 to 58+/-5 (P<0.01) in 30 min and then returned to the control value in 2 h (9+/-2, P>0.05), and (2) in the multiple consecutive seizure rats the increase in 30 min (22+/-3) was less than that in the single seizure rats (P<0.01), and the number returned to normal in 1 h (6+/-1, P>0.05). These data indicate that the transient increase in CCK mRNA level in amygdala following single or multiple consecutive seizures of P77PMC may be involved in anti-convulsant mechanisms in response to acute seizures.
Ni
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Departments of Physiology, Qingdao University, Qingdao 266021, China.
Xu
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Tang
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wang
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SB
D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D002766:Cholecystokinin / Q000096:biosynthesis* / Q000235:genetics; D020195:Epilepsy, Reflex / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains
D012333:RNA, Messenger; D002766:Cholecystokinin