Interleukin-6 and the development of social disruption-induced glucocorticoid resistance.
Following social disruption (SDR) stress in male mice, corticosterone resistance of splenocytes was accompanied by enhanced LPS-stimulated interleukin (IL)-6 secretion. The present study examined the role of IL-6 in the development of corticosterone resistance. Addition of IL-6 to control splenocyte cultures did not induce corticosterone resistance. SDR also elevated IL-6 in plasma and liver, but not in spleen. IL-6 deficient mice that were exposed to SDR developed glucocorticoid resistance despite the absence of systemic IL-6. These findings suggest that although SDR enhanced IL-6 responses, IL-6 was not essential for the development of stress-induced splenocyte corticosterone resistance.
Stark
Jennifer L
JL
Neuroscience Graduate Studies Program, The Ohio State University Health Sciences Center, Columbus, OH 43218, USA.
Avitsur
Ronit
R
Hunzeker
John
J
Padgett
David A
DA
Sheridan
John F
JF
D000818:Animals; D003345:Corticosterone / Q000494:pharmacology*; D004351:Drug Resistance; D015850:Interleukin-6 / Q000494:pharmacology / Q000502:physiology*; D007398:Interpersonal Relations; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000503:physiopathology*; D013315:Stress, Psychological / Q000209:etiology* / Q000503:physiopathology*
D015850:Interleukin-6; D008070:Lipopolysaccharides; D003345:Corticosterone