Gamma interferon fails to induce expression of indoleamine 2,3-dioxygenase and does not control the growth of Chlamydophila abortus in BeWo trophoblast cells.
The BeWo trophoblast cell line does not constitutively express the tryptophan degrading enzyme indolamine 2,3-dioxygenase (IDO), nor can IDO expression be induced by gamma interferon. This correlates with the inability of BeWo cells to control the growth of Chlamydophila abortus, in contrast to effects observed in HeLa cells treated with gamma interferon.
Entrican
Gary
G
Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh EH26 0PZ, Scotland, United Kingdom. gary.entrican@mri.sari.ac.uk
Wattegedera
Sean
S
Chui
Michelle
M
Oemar
Lyn
L
Rocchi
Mara
M
McInnes
Colin
C
D000022:Abortion, Spontaneous / Q000209:etiology*; D023501:Chlamydophila / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity; D002691:Chlamydophila psittaci; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006367:HeLa Cells; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007371:Interferon-gamma / Q000494:pharmacology*; D011247:Pregnancy; D014327:Trophoblasts / Q000382:microbiology*; D014366:Tryptophan Oxygenase / Q000096:biosynthesis*; D014407:Tumor Cells, Cultured
D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007371:Interferon-gamma; D014366:Tryptophan Oxygenase