title: [Study on expression of norepinephrine and dopamine placental tissues of normal pregnancy and pregnancy induced hypertension syndrome].
abstract: OBJECTIVE
  To study the distribution and levels of norepinephrine (NE) and dopamine (DA) in placenta tissues of normal pregnancy and pregnancy induced hypertension syndrome (PIH) and discuss the relationship of NE and DA with PIH.
  
  
  METHODS
  Control group was consisted of thirty-one normal pregnancies divided into three stages (early, middle and late). Study group was consisted of thirty-eight women with PIH in mild, moderate and severe degrees. The distribution and levels of NE and DA in the placental tissues were detected by immunohistochemistry (SP) and computer image analysis.
  
  
  RESULTS
  (1) In the control group, the levels of NE and DA located in the cell membrane and cytoplasm of cytotrophoblast were higher in early pregnancy than that located in the cell membrane and cytoplasm of syncytiotrophoblast and endothelium of capillary vessel in middle and late stages. The results in PIH were same as late stage in control group. (2) The expression of NE (1.595 +/- 0.018) and DA (1.552 +/- 0.067) were decreased gradually in early pregnancy than that of NE (1.488 +/- 0.019, 1.419 +/- 0.014, P < 0.01) and DA (1.305 +/- 0.023, 1.237 +/- 0.024, P < 0.01) in middle and late stages in control group; the expression of DA following with the PIH degrees were decreased (1.378 +/- 0.029 vs 1.305 +/- 0.023 vs 1.237 +/- 0.024, P < 0.01); the expression of NE following the PIH degrees were increased (1.494 +/- 0.018 vs 1.624 +/- 0.014 vs 1.917 +/- 0.044, P < 0.01).
  
  
  CONCLUSIONS
  These findings suggested that NE and DA located in placental cytotrophoblast in early pregnancy and syncytiotrophoblast in middle and late stages and continuously distributed properly with the gestation. The level of NE increased with degrees PIH.
authors.affiliation: Department of Obstetrics and Gynecology, Jilin Provincial People's Hospital, Changchun 130021, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.forename: Weiyuan
authors.initials: W
authors.lastname: Zhang
authors.forename: Mo
authors.initials: M
authors.lastname: Chen
authors.forename: Nianzhi
authors.initials: N
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Guo
mesh_terms: D000328:Adult; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D003600:Cytosol / Q000737:chemistry / Q000378:metabolism; D004298:Dopamine / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism*; D010920:Placenta / Q000737:chemistry / Q000166:cytology / Q000378:metabolism; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000378:metabolism*; D014327:Trophoblasts / Q000737:chemistry / Q000378:metabolism*
chemical_list: D004298:Dopamine; D009638:Norepinephrine