title: Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs.
abstract: Over the last decades, the interest in the relationships between the pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobial agents has increased and, therefore, the use of PK/PD indices and expressions has spread widely. The appropriate definition and use of these parameters is a matter of controversy. This paper contains a proposal to use PK/PD expressions for antimicrobial agents and their units in a uniform manner.
authors.affiliation: Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 sz Nijmegen, The Netherlands. mouton@cwz.nl
authors.forename: Johan W
authors.initials: JW
authors.lastname: Mouton
authors.forename: Michael N
authors.initials: MN
authors.lastname: Dudley
authors.forename: Otto
authors.initials: O
authors.lastname: Cars
authors.forename: Hartmut
authors.initials: H
authors.lastname: Derendorf
authors.forename: George L
authors.initials: GL
authors.lastname: Drusano
mesh_terms: D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D009626:Terminology as Topic
chemical_list: D000890:Anti-Infective Agents