Pharmacokinetics of intravenous busulfan in children prior to stem cell transplantation.
OBJECTIVE
Intravenous formulations of busulfan have recently become available. Although busulfan is used frequently in children as part of a myeloablative regimen prior to bone marrow transplantation, pharmacokinetic data on intravenous busulfan in children are scarce. The aim was to investigate intravenous busulfan pharmacokinetics in children and to suggest a limited sampling strategy in order to determine busulfan systemic exposure with the minimum of inconvenience and risk for the patient.


METHODS
Plasma pharmacokinetics after the first administration was investigated in six children using nonlinear mixed effect modelling.


RESULTS
Pharmacokinetics showed little variability and were described adequately with a one-compartment model (population estimates CL,av=0.29 l h(-1) kg(-1); V,av=0.84 l kg(-1); t(1/2)=1.7-2.8 h). Combined with limited sampling and a Bayesian fitting procedure, the model can adequately estimate the systemic exposure to intravenous busulfan, which in children appears to be at the lower end of the adult range.


CONCLUSIONS
Busulfan systemic exposure in children during intravenous administration can be estimated adequately with limited sampling and a Bayesian fitting procedure from a one-compartment model. Intravenous busulfan pharmacokinetics in children should be the subject of more research.
Cremers
Serge
S
Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands. S.C.L.M.Cremers@lumc.nl
Schoemaker
Rik
R
Bredius
Robbert
R
den Hartigh
Jan
J
Ball
Lynne
L
Twiss
Irene
I
Vermeij
Pieter
P
Vossen
Jaak
J
D000293:Adolescent; D019540:Area Under Curve; D001499:Bayes Theorem; D002066:Busulfan / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D006207:Half-Life; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007223:Infant; D007275:Injections, Intravenous; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000628:therapy; D013789:Thalassemia / Q000097:blood / Q000628:therapy; D019172:Transplantation Conditioning
D007166:Immunosuppressive Agents; D002066:Busulfan