title: Contribution of nasal pathways to low frequency respiratory impedance in infants.
abstract: BACKGROUND
  In infants the impedance of the nasal pathways (Zn) is a significant proportion of the total respiratory impedance (Zrs).
  
  
  METHODS
  In 11 infants Zrs was partitioned into Zn and lower respiratory system impedance (Zlrs) using a nasal catheter. A low frequency oscillatory signal (0.5-20 Hz) was applied during a pause in breathing to obtain the impedance spectra. A model of the respiratory system containing an airway and tissue compartment was then fitted to Zrs and Zlrs. The airway compartment consisted of a frequency independent resistance (R) and inertance (I), while the tissue compartment was described by coefficients of tissue damping (G) and elastance (H).
  
  
  RESULTS
  Zrs could be reliably partitioned into Zn and Zlrs. The nasal pathway acted as a purely resistive-inertive impedance and contributed approximately half of the airway resistance (mean (SE) 44.6 (4.9)%) and most of the respiratory system inertance (71.7 (3.5)%).
  
  
  CONCLUSIONS
  In studies investigating changes in airway resistance in nasally breathing infants, the separation of nasal and lower respiratory system mechanics will increase the sensitivity of the tests.
authors.affiliation: Division for Clinical Sciences, Institute for Child Health Research, University of Western Australia, Perth 6840, Australia. graham@ichr.uwa.edu.au
authors.forename: Graham L
authors.initials: GL
authors.lastname: Hall
authors.forename: Z
authors.initials: Z
authors.lastname: Hantos
authors.forename: J H
authors.initials: JH
authors.lastname: Wildhaber
authors.forename: P D
authors.initials: PD
authors.lastname: Sly
mesh_terms: D000403:Airway Resistance / Q000502:physiology*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D009666:Nose / Q000502:physiology*; D012680:Sensitivity and Specificity