title: Effects of cisapride on oesophageal transit of solids in patients with progressive systemic sclerosis.
abstract: In most patients with progressive systemic sclerosis (PSS) the oesophagus is affected. Reflux symptoms are most frequent, whilst dysphagia also occurs. Cisapride, a prokinetic agent, may enhance motility along the gastrointestinal tract. The effects of cisapride on oesophageal transit were evaluated in 12 PSS patient using a solid-phase radionuclide oesophageal transit study. Each PSS patient was given cisapride 10 mg or placebo orally three times a day in a random, double-blind, crossover fashion. The results show that cisapride does not seem to have any impact on oesophageal transit in patients with PSS.
authors.affiliation: Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan. sjwang@vhgtc.vghtc.gov.tw
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
authors.forename: J L
authors.initials: JL
authors.lastname: La
authors.forename: D Y
authors.initials: DY
authors.lastname: Chen
authors.forename: Y H
authors.initials: YH
authors.lastname: Chen
authors.forename: T Y
authors.initials: TY
authors.lastname: Hsieh
authors.forename: W Y
authors.initials: WY
authors.lastname: Lin
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D020117:Cisapride / Q000008:administration & dosage / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D015154:Esophageal Motility Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D004947:Esophagus / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology*; D005260:Female; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012595:Scleroderma, Systemic / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D020117:Cisapride