title: Treatment of disseminated granuloma annulare with a 5-lipoxygenase inhibitor and vitamin E.
abstract: Histologically, granuloma annulare (GA) is a common non-infectious necrobiotic granulomatous reaction pattern that correlates with a number of different, but relatively specific clinical presentations. The cause or causes of GA are unknown: when localized, it is usually self-limiting, but it may be persistent when disseminated. We present three women who had had disseminated GA for more than 1 year. One patient had previously been treated with isotretinoin with no response. All three patients were treated with vitamin E 400 IU daily and zileuton 2400 mg daily. All responded within 3 months with complete clinical clearing. The anti-inflammatory and immune regulatory effects of vitamin E and zileuton may be an effective treatment in some patients with prolonged disseminated/generalized GA.
authors.affiliation: Department of Dermatology, University of Alabama, Eye Foundation Hospital, Suite 414, 1720 University Blvd, Birmingham, AL 35294-0009, U.S.A. hskelton@path.uab.edu
authors.forename: Kathleen J
authors.initials: KJ
authors.lastname: Smith
authors.forename: C
authors.initials: C
authors.lastname: Norwood
authors.forename: H
authors.initials: H
authors.lastname: Skelton
mesh_terms: D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D016460:Granuloma Annulare / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D006918:Hydroxyurea / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use*; D008875:Middle Aged; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D016859:Lipoxygenase Inhibitors; D014810:Vitamin E; C063449:zileuton; D006918:Hydroxyurea