Polymorphisms of chromogranin B gene associated with schizophrenia in Chinese Han population.
Chromogranin is a widespread family of proteins in the neurosystem, whose function is guiding the sorting and secretion of neuropeptides. Using functional and positional evidences, chromogranin B was selected as a candidate gene for schizophrenia. We systematically screened all the promoter and exon regions of the gene and detected 15 single nucleotide polymorphisms (SNPs), among which four SNPs (including two non-synonymous SNPs) were selected for association analysis. In a cohort of Chinese Han schizophrenia cases and controls, the results of both the individual SNPs and the haplotypes of SNPs were significantly positive (P<0.01). Our results confirm the role of neuropeptides in the pathogenesis of schizophrenia.
Zhang
Bifeng
B
Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 200030, PR China.
Tan
Zheng
Z
Zhang
Changshun
C
Shi
Yongyong
Y
Lin
Zhixin
Z
Gu
Niufan
N
Feng
Guoyin
G
He
Lin
L
D000328:Adult; D000595:Amino Acid Sequence / Q000235:genetics; D002490:Central Nervous System / Q000378:metabolism* / Q000503:physiopathology; D002681:China / Q000208:ethnology; D053378:Chromogranin B; D002864:Chromogranins / Q000235:genetics* / Q000378:metabolism; D004252:DNA Mutational Analysis; D005091:Exons / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D009479:Neuropeptides / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*
C506134:CHGB protein, human; D053378:Chromogranin B; D002864:Chromogranins; D005819:Genetic Markers; D009479:Neuropeptides