title: Increased hippocampal volume in schizophrenics' parents with ancestral history of schizophrenia.
abstract: OBJECTIVE
  Decreased hippocampal volume is one of the hypothesized pathological features of schizophrenia, but it is not known if this abnormality is familially transmitted. The aim of this study was to measure the hippocampal volume of the parents of schizophrenic probands, in relationship to the apparent transmission of genetic risk.
  
  
  METHODS
  Eighteen subjects from families consisting of a schizophrenic proband and two clinically unaffected parents were studied. Probands were compared to six control subjects, matched for age, sex, and educational level. The six families were selected so that only one parent had an ancestral family history of schizophrenia. The volumes of both hippocampi were measured by magnetic resonance imaging and adjusted for age and whole brain volume.
  
  
  RESULTS
  The total hippocampal volumes of the parents with ancestral family history of schizophrenia were significantly larger than those of their schizophrenic offspring.
  
  
  CONCLUSIONS
  This study suggests that decreased hippocampal volume in schizophrenia is not a familially transmitted abnormality. Rather, it appears that clinically unaffected parents who transmit apparent genetic risk for schizophrenia may have increased hippocampal volume, which may be a protective factor against the illness.
authors.affiliation: Department of Psychiatry, University of Colorado School of Medicine, 4200 E. 9th Avenue, Denver, CO 80262, USA.
authors.forename: Josette G
authors.initials: JG
authors.lastname: Harris
authors.forename: David A
authors.initials: DA
authors.lastname: Young
authors.forename: Donald C
authors.initials: DC
authors.lastname: Rojas
authors.forename: Ana
authors.initials: A
authors.lastname: Cajade-Law
authors.forename: Ann
authors.initials: A
authors.lastname: Scherzinger
authors.forename: Safia
authors.initials: S
authors.lastname: Nawroz
authors.forename: Lawrence E
authors.initials: LE
authors.lastname: Adler
authors.forename: C Munro
authors.initials: CM
authors.lastname: Cullum
authors.forename: Jack
authors.initials: J
authors.lastname: Simon
authors.forename: Robert
authors.initials: R
authors.lastname: Freedman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012306:Risk; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology