title: Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma.
abstract: Tumor angiogenesis plays a significant role in cancer growth and metastasis. This complex process is influenced by a variety of angiogenic factors. Elevated serum levels or high expression of some of these factors have been shown to correlate with stage and prognosis in certain human malignancies. This has been demonstrated most consistently for vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). We tried to establish, whether pre-treatment serum levels of the angiogenic factors VEGF, bFGF, interleukin 8 (IL-8) and Flt3 ligand (Flt3L) correlate with prognostic variables in 30 patients with primary gastro-intestinal non-Hodgkin's lymphoma. Our results suggest that higher pretreatment serum levels of IL-8 and Flt3L are associated with higher stage (>or= II) and high grade, respectively. Elevated pretreatment serum levels of VEGF and bFGF were not associated with advanced disease characteristics and carried no prognostic information.
authors.affiliation: Department of Medicine, University of Muenster, Germany. retzlaff@uni-muenster.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Retzlaff
authors.forename: Teresa
authors.initials: T
authors.lastname: Padró
authors.forename: Peter
authors.initials: P
authors.lastname: Koch
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Oelmann
authors.forename: Norbert
authors.initials: N
authors.lastname: Lügering
authors.forename: Rolf M
authors.initials: RM
authors.lastname: Mesters
authors.forename: Wolfgang E
authors.initials: WE
authors.lastname: Berdel
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis* / Q000097:blood; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000097:blood; D008875:Middle Aged; D011379:Prognosis; D013995:Time
chemical_list: D014408:Biomarkers, Tumor; D016207:Cytokines; D016209:Interleukin-8; D008565:Membrane Proteins; C084881:flt3 ligand protein