Frequency modulation of mesenteric and renal vascular resistance.
The hypothesis was tested that low-frequency vasomotions in individual vascular beds are integrated by the cardiovascular system, such that new fluctuations at additional frequencies occur in arterial blood pressure. In anesthetized rats (n = 8), the sympathetic splanchnic and renal nerves were simultaneously stimulated at combinations of frequencies ranging from 0.075 to 0.8 Hz. Blood pressure was recorded together with mesenteric and renal blood flow velocities. Dual nerve stimulation at low frequencies (<0.6 Hz) caused corresponding oscillations in vascular resistance and blood pressure, whereas higher stimulation frequencies increased the mean levels. Blood pressure oscillations were only detected at the individual stimulation frequencies and their harmonics. The strongest periodic responses in vascular resistance were found at 0.40 +/- 0.02 Hz in the mesenteric and at 0.32 +/- 0.03 Hz (P < 0.05) in the renal vascular bed. Thus frequency modulation of low-frequency vasomotions in individual vascular beds does not cause significant blood pressure oscillations at additional frequencies. Furthermore, our data suggest that sympathetic modulation of mesenteric vascular resistance can initiate blood pressure oscillations at slightly higher frequencies than sympathetic modulation of renal vascular resistance.
Grisk
Olaf
O
Institut für Physiologie, Ernst-Moritz-Arndt-Universität Greifswald, 17495 Karlsburg, Germany.
Stauss
Harald M
HM
D000818:Animals; D001808:Blood Vessels / Q000294:innervation; D004558:Electric Stimulation; D006439:Hemodynamics / Q000502:physiology; D007668:Kidney / Q000294:innervation; D008955:Models, Cardiovascular; D051381:Rats; D017207:Rats, Sprague-Dawley; D012079:Renal Circulation / Q000502:physiology*; D013152:Splanchnic Circulation / Q000502:physiology*; D013153:Splanchnic Nerves / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology*