title: Osteochondromatosis with high concentration of procollagen II C peptide in joint fluid.
abstract: Procollagen II C peptide is used as a joint fluid marker of collagen synthesis by chondrocytes in patients with osteoarthritis. Since osteochondromatosis activates ectopic chondrogenesis in the synovial membrane, procollagen II C peptide is expected to be a good marker of the disease. Procollagen II C peptide can be used to evaluate the condition of the disease metabolically by simply aspirating the joint fluid. We have experienced a case of osteochondromatosis (Miligram's stage 2) with a high concentration of procollagen II C peptide. This case suggests that the concentration of procollagen II C peptide is a good marker of chondrogenesis by osteochondromatosis.
authors.affiliation: Department of Orthopaedic Surgery, National Defence Medical College, 3-2, Namiki, Tokorozawa, Saitama 359-8513, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Fujikawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sasazaki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Aoki
mesh_terms: D000328:Adult; D015838:Chondromatosis, Synovial / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000032:analysis*; D011347:Procollagen / Q000032:analysis*; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: D010446:Peptide Fragments; D011347:Procollagen; C093212:procollagen type II carboxy-terminal peptide