Lp-PLA2: an emerging biomarker of coronary heart disease.
Cardiovascular disease is the leading cause of death in most industrialized countries. However, the diagnosis and management of coronary heart disease is far from optimal. Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet-activating factor acetylhydrolase, is an enzyme that hydrolyses oxidized phospholipids and is primarily associated with low-density lipoprotein. Discussed in this review is the accumulating evidence supporting the view that Lp-PLA2 is a potential biomarker of coronary heart disease and plays and an important proinflammatory role in the progression of atherosclerosis. A new ELISA method for the quantitative measurement of Lp-PLA2 mass in human plasma developed by diaDexus, Inc. is presented. Furthermore, potential clinical applications of Lp-PLA2 mass measurements are proposed.
Dada
Nisha
N
Dia Dexus, Inc, 343 Oyster Point Boulevard, South San Francisco, Ca. 94080-1913, USA. ndada@diadexus.com
Kim
Nam W
NW
Wolfert
Robert L
RL
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D001161:Arteriosclerosis / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D010741:Phospholipases A / Q000097:blood* / Q000737:chemistry / Q000235:genetics; D054467:Phospholipases A2; D012044:Regression Analysis; D012307:Risk Factors
D015415:Biomarkers; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D010741:Phospholipases A; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase