[The influence of the hormonal replacement therapy on conjunctival epithelium morphology among peri- and postmenopausal women].
OBJECTIVE
To estimate the status of the conjunctival morphology among women treated due to endocrinological or gynecological indications with hormone replacement therapy.


METHODS
60 women treated with hormonal replacement therapy (HRT) were divided into three groups of examination: group 1 (20 women), treated with HRT after up to 1 year of menopausal symptoms, group 2 (20 women) treated with HRT between 1-5 years of menopausal symptoms, group 3 (20 women) treated with HRT after more than 5 years of menopausal symptoms. The morphology of the conjunctival epithelium was assessed by impressive cytology. The examinations were performed 3, 6, 12 months after HRT treatment. The values obtained before HRT treatment served as control.


RESULTS
The preliminary examinations showed changes of the morphology of conjunctival epithelium in all groups. The longer duration of postmenopausal period, the more advanced morphological changes. In all groups of examinations the HRT has the beneficial influence on the state of conjunctival epithelium morphology.


CONCLUSIONS
The age and changes of the hormonal homeostasis have negative influence on conjunctival epithelium morphology among peri- and postmenopausal women. HRT treatment has beneficial effect on the conjunctival epithelium morphology. Our results suggest that hormonal replacement therapy can be suitable for prevention and treatment of postmenopausal conjunctival changes.
Okoń
A
A
Klinicznego Oddziału Okulistycznego 10 Wojskowego Szpitala Klinicznego z Poliklinika, SPZOZ w Bydgoszczy.
Jurowski
P
P
Goś
R
R
D000367:Age Factors; D000368:Aged; D002979:Climacteric; D003228:Conjunctiva / Q000187:drug effects*; D004848:Epithelium / Q000187:drug effects; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D013997:Time Factors
D004967:Estrogens