title: Interleukin 6 and tumour necrosis factor alpha serum levels in monoclonal gammopathy of undetermined significance.
abstract: The objectives of the present study were to compare the interleukin 6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) serum levels of individuals with monoclonal gammopathy of undetermined significance (MGUS) with those of healthy controls, and to ascertain the predictor value of these cytokines in the evolution from MGUS to multiple myeloma. After a median follow-up of 7 years from the initial cytokine measurements, nine patients with MGUS have evolved to a malignant condition. The actuarial probability of malignant transformation in patients with increased IL-6 and TNF-alpha was not significantly higher than in those with normal values.
authors.affiliation: Institute of Hematology and Oncology, Farreras-Valentí Postgraduate School of Hematology, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain. jblade@clinic.ub.es
authors.forename: Joan
authors.initials: J
authors.lastname: Bladé
authors.forename: Xabier
authors.initials: X
authors.lastname: Filella
authors.forename: Silvia
authors.initials: S
authors.lastname: Montoto
authors.forename: Francesc
authors.initials: F
authors.lastname: Bosch
authors.forename: Laura
authors.initials: L
authors.lastname: Rosiñol
authors.forename: Francesca
authors.initials: F
authors.lastname: Coca
authors.forename: Eva
authors.initials: E
authors.lastname: Giné
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Nadal
authors.forename: Marta
authors.initials: M
authors.lastname: Aymerich
authors.forename: María
authors.initials: M
authors.lastname: Rozman
authors.forename: Emili
authors.initials: E
authors.lastname: Montserrat
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D009101:Multiple Myeloma; D010265:Paraproteinemias / Q000097:blood*; D011336:Probability; D011379:Prognosis; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha