Drug metabolism in the skin.
The skin performs a wide range of active metabolic functions including xenobiotic metabolism involving metabolizing enzymes specific to the skin. In this review we focus on the role of drug metabolism: (i) in allergic reactions to substances of low molecular weight; (ii) in cutaneous vitamin A and D3 metabolism and its modulation; (iii) in the interaction of transport and metabolic enzymes in skin cells; and (iv) on novel tools for the measurement of drug metabolism in various compartments of the human skin.
Baron
J M
JM
Department of Dermatology, University Hospital, RWTH Aachen, Aachen, Germany. jensmalte.baron@post.rwth-aachen.de
Merk
H F
HF
D004342:Drug Hypersensitivity / Q000209:etiology; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012867:Skin / Q000166:cytology / Q000378:metabolism*
D004364:Pharmaceutical Preparations