title: Interleukin-1 beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells.
abstract: This study reports that in Schwann cell tissue culture the administration of the two pro-inflammatory cytokines, interleukin-1 beta (IL-1 beta) and interferon-gamma (IFN-gamma), at different dosages, singly or in combination, can induce apoptosis and/or mitosis. Schwann cell apoptosis was maximal within 24 h of stimulation with 50 U/ml of IFN-gamma, while proliferation was at its peak within 24 h with 10 U/ml IL-1 beta, and both processes decreased progressively by 48 and 72 h. Moreover, the combination of the two cytokines did not show any synergistic effect. These data can be interpreted as a possible involvement of pro-inflammatory cytokines not only in myelin disruption but also in promoting remyelination.
authors.affiliation: Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Conti
authors.forename: Anto
authors.initials: A
authors.lastname: De Pol
authors.forename: Elio
authors.initials: E
authors.lastname: Scarpini
authors.forename: Fabiana
authors.initials: F
authors.lastname: Vaccina
authors.forename: Milena
authors.initials: M
authors.lastname: De Riz
authors.forename: PierLuigi
authors.initials: P
authors.lastname: Baron
authors.forename: Marco
authors.initials: M
authors.lastname: Tiriticco
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Scarlato
mesh_terms: D000818:Animals; D017209:Apoptosis; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004338:Drug Combinations; D018836:Inflammation Mediators / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology*; D007375:Interleukin-1 / Q000494:pharmacology*; D008854:Microscopy, Electron; D051381:Rats; D017207:Rats, Sprague-Dawley; D012583:Schwann Cells / Q000166:cytology* / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D018836:Inflammation Mediators; D007375:Interleukin-1; D007371:Interferon-gamma