title: Galanin-like peptide stimulates food intake in the rat.
abstract: We have isolated a novel hypothalamic peptide, Galanin-like peptide (GALP), as a ligand for galanin receptor subtype GalR2. To investigate the physiological role of GALP, we examined the effect of the intracerebroventricular administration of GALP and found that GALP induced food intakes. GALP had ten-fold the orexigenic activity of galanin. We also observed the anxiogenic-like behavior after the administration of 1 nmol GALP. These results suggest that GALP is a novel orexigenic and anxiogenic peptide.
authors.affiliation: Pharmaceutical Research Division, Takeda Chemical Industries Ltd., Jusohonmachi 2-17-85, Yodogawa, Osaka, 532-8686, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Takuya
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yuka
authors.initials: Y
authors.lastname: Adachi
authors.forename: Takashi
authors.initials: T
authors.lastname: Itoh
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ohtaki
authors.forename: Haruo
authors.initials: H
authors.lastname: Onda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kurokawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Nishimura
authors.forename: Masahiko
authors.initials: M
authors.lastname: Fujino
mesh_terms: D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D001069:Appetite Regulation / Q000187:drug effects / Q000502:physiology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D019004:Galanin / Q000378:metabolism* / Q000494:pharmacology; D044089:Galanin-Like Peptide; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism* / Q000494:pharmacology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D044089:Galanin-Like Peptide; D009419:Nerve Tissue Proteins; D019004:Galanin