Naïve to memory T-cell differentiation during homeostasis-driven proliferation.
During homeostasis-driven T-cell proliferation, naïve T cells stably acquire the cell surface markers and functional properties of antigen-induced memory T cells. Thus, in T-cell-deficient individuals, homeostasis-driven T-cell proliferation appears to restore only the memory T-cell compartment, whereas the reconstitution of the naïve T-cell compartment depends on de novo T-cell development in the thymus.
Ge
Qing
Q
Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, E17-128, 40 Ames Street, Cambridge, MA 02139, USA.
Hu
Hui
H
Eisen
Herman N
HN
Chen
Jianzhu
J
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D006649:Histocompatibility Antigens / Q000276:immunology; D006706:Homeostasis; D007156:Immunologic Memory / Q000276:immunology*; D010641:Phenotype; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology*
D006649:Histocompatibility Antigens