title: [The early changes of tear film after laser in situ keratomileusis].
abstract: OBJECTIVE
  To investigate the early changes of tear film after laser in situ keratomileusis (LASIK).
  
  
  METHODS
  One hundred and forty-eight myopic eyes that underwent LASIK were randomly chosen. The eyes were observed for subjective complaints of dry eye, fluorescein staining (Fl), rose bengal staining (Rb), tear break-up time (BUT), Schirmer's I test preoperatively and 1 day, 1 week, 1 month, 3 months postoperatively.
  
  
  RESULTS
  The subjective complaints of dry eye were more severe after the operation. There were obvious decreases in BUT at 1 day, 1 week, 1 month and 3 months postoperatively relative to the preoperative level (P < 0.05). The Schirmer's I test result was higher at 1 day but without statistical significance (P > 0.05), but lower at 1 week, 3 months (P < 0.05) after LASIK. No changes were observed in Schirmer's I test between preoperative and 1 month postoperative value (P > 0.05). Rb and Fl staining dots were more concentrated at 1 day and 1 week postoperatively (P < 0.0127). No significant changes were found in Rb staining at 1 month and 3 months postoperatively.
  
  
  CONCLUSIONS
  LASIK does have some effects on tear film.
authors.affiliation: Zhongshan Ophthalmic Center, Statistical Teaching and Researching Department of Sun Yat-sen University, Guangzhou 510060, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Junshu
authors.initials: J
authors.lastname: Wu
authors.forename: Guofu
authors.initials: G
authors.lastname: Huang
authors.forename: Zongli
authors.initials: Z
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D003315:Cornea / Q000473:pathology / Q000601:surgery; D015352:Dry Eye Syndromes / Q000209:etiology*; D005260:Female; D019793:Fluorescein / Q000032:analysis; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects* / Q000379:methods; D007765:Lacrimal Apparatus / Q000503:physiopathology; D008297:Male; D009216:Myopia / Q000601:surgery*; D011183:Postoperative Complications; D012395:Rose Bengal / Q000032:analysis; D013666:Tears / Q000378:metabolism*
chemical_list: D012395:Rose Bengal; D019793:Fluorescein