title: Comparative pharmacodynamics of three newer fluoroquinolones versus six strains of staphylococci in an in vitro model under aerobic and anaerobic conditions.
abstract: Six strains of staphylococci were exposed to levofloxacin, moxifloxacin, or trovafloxacin in an in vitro pharmacodynamic model under both aerobic and anaerobic conditions. Each agent demonstrated a rapid 3-log(10) kill versus susceptible isolates regardless of condition. Against clinical isolates with reduced susceptibility, regrowth occurred by 24 h and was frequently associated with further increases in MICs.
authors.affiliation: University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota 55455, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Wright
authors.forename: Brent W
authors.initials: BW
authors.lastname: Gunderson
authors.forename: Laurie B
authors.initials: LB
authors.lastname: Hovde
authors.forename: Gigi H
authors.initials: GH
authors.lastname: Ross
authors.forename: Khalid H
authors.initials: KH
authors.lastname: Ibrahim
authors.forename: John C
authors.initials: JC
authors.lastname: Rotschafer
mesh_terms: D000332:Aerobiosis; D000693:Anaerobiosis; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D008712:Methicillin / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D010406:Penicillins / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010406:Penicillins; D008712:Methicillin