Clinical potentials of neuropeptide Y family of hormones.
Neuropeptide Y (NPY) family of hormones exhibits a wide spectrum of central and peripheral activities mediated by six G-protein coupled receptor subtypes denoted as Y1, Y2, Y3, Y4, Y5, and y6. Investigations to date have implicated NPY in the pathophysiology of a number of diseases including feeding disorders, seizures, anxiety, diabetes, hypertension, congestive heart failure and intestinal disorders. These observations suggest that long-acting, potent NPY receptor selective agonists and antagonists developed could be used to treat a variety of diseases. These possibilities are discussed in this paper.
Balasubramaniam
Ambikaipakan
A
Division of Gastrointestinal Hormones, Department of Surgery, University of Cincinnati Medical Center, Cincinnati, OH 45267-0558, USA. Ambi.bala@UC.EDU
D001068:Feeding and Eating Disorders / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D008286:Malabsorption Syndromes / Q000503:physiopathology*; D009478:Neuropeptide Y / Q000502:physiology*; D017476:Receptors, Neuropeptide Y / Q000145:classification / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology*
D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y