Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism.
A series of farnesoic acid derivatives was prepared and their morphogenic regulatory activities were evaluated. Their inhibitory activities against yeast cell growth and yeast-to-hypha transition examined in Candida albicans cells are dependent upon the chain length as well as the substitution patterns on the isoprenoid template. The preliminary structure-activity relationship of these compounds is described to elucidate the essential structural requirements.
Kim
Sanghee
S
Natural Products Research Institute, Seoul National University, 28 Yungun, Jongro, 110-460, Seoul, Republic of Korea. pennkim@snu.ac.kr
Kim
Eunkyung
E
Shin
Dong Sun
DS
Kang
Heonjoong
H
Oh
Ki Bong
KB
D002176:Candida albicans / Q000166:cytology / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis* / Q000494:pharmacology; D025301:Hyphae / Q000187:drug effects / Q000254:growth & development; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D015003:Yeasts / Q000166:cytology / Q000187:drug effects
D005231:Fatty Acids, Unsaturated; C007702:farnesoic acid