Influence of effector molecules on the CD8(+) T cell response to infection.
Expansion and contraction of antigen-specific CD8(+) T cells after infection or vaccination results in stable memory. Recent evidence demonstrates that anti-microbial effector molecules such as perforin and IFN-gamma regulate specific aspects of CD8(+) T cell homeostasis by mechanisms that may be dependent or independent of pathogen clearance.
Harty
John T
JT
Department of Microbiology, and Interdisciplinary Graduate Program in Immunology, University of Iowa, 3-512 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA.
Badovinac
Vladimir P
VP
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D007156:Immunologic Memory; D007239:Infections / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000502:physiology; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins
D016207:Cytokines; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D054353:Perforin