title: Electrospray ionization mass spectrometric studies of phosphorus oxychloride directed synthesis of homo-oligopeptide ester libraries.
abstract: With the assistance of phosphorus oxychloride, alpha-amino acids were assembled into homo-peptides, which were analyzed by electrospray ionization mass spectrometry (ESI-MS) and multistage electrospray ionization mass spectrometry (ESI-MS/MS). On quenching with water or various alcohols, the reaction mixtures yielded the corresponding peptides or peptide esters, respectively. This paper reports a simple method to synthesize the homo-oligo-peptide-ester conjugated library by phosphorus oxychloride activation.
authors.affiliation: School of Chemistry and Engineering, Xiamen University, 361005, P.R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhou
authors.forename: Kui
authors.initials: K
authors.lastname: Lu
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.forename: Guo
authors.initials: G
authors.lastname: Tang
authors.forename: Shu-Xia
authors.initials: SX
authors.lastname: Cao
authors.forename: Ling-Bo
authors.initials: LB
authors.lastname: Qu
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Zhao
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D007202:Indicators and Reagents; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D019151:Peptide Library; D017553:Phosphorus Compounds / Q000737:chemistry*; D012044:Regression Analysis; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000596:Amino Acids; D007202:Indicators and Reagents; D009842:Oligopeptides; D019151:Peptide Library; D017553:Phosphorus Compounds; C013196:phosphoryl chloride