Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group.
A large scale multicenter study of cerebrospinal fluid (CSF) tau levels was conducted to determine the cut-off value, sensitivity and specificity for clinical usage as a biomarker of Alzheimer's disease (AD). Its use for early and differential diagnosis and the factors that increase CSF tau levels were also examined. CSF samples from a total of 1,031 subjects including 366 patients with AD, 168 patients with non-Alzheimer type dementia (NA), 316 patients with non-dementia neurological diseases (ND) and 181 normal controls (NC) were measured using ELISA for tau. The cut-off value of tau, 375 pg/ml, showed 59.1% sensitivity and 89.5% specificity for diagnosis of AD compared with the other groups. The tau levels were increased from the early to late stages of AD. Elevation of CSF tau in the non-tauopathy and tauopathy dementia groups, chronic and acute damage to the cerebrum, and meningeal disturbance were other factors that required attention for clinical practice. Measurement of CSF tau was useful as a biomarker for early and differential diagnosis of AD.
Shoji
Mikio
M
Department of Neurology, Division of Neuroscience/Biophysical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. mshoji@cc.okayama-u.ac.jp
Matsubara
Etsuro
E
Murakami
Tetsuro
T
Manabe
Yasuhiro
Y
Abe
Koji
K
Kanai
Mitsuyasu
M
Ikeda
Masaki
M
Tomidokoro
Yasushi
Y
Shizuka
Masami
M
Watanabe
Mitsunori
M
Amari
Masakuni
M
Ishiguro
Koji
K
Kawarabayashi
Takeshi
T
Harigaya
Yasuo
Y
Okamoto
Koichi
K
Nishimura
Tsuyosi
T
Nakamura
Yu
Y
Takeda
Masatoshi
M
Urakami
Katsuya
K
Adachi
Yoshiki
Y
Nakashima
Kenji
K
Arai
Hiroyuki
H
Sasaki
Hidetada
H
Kanemaru
Kazutomi
K
Yamanouchi
Hiroshi
H
Yoshida
Yasuji
Y
Ichise
Kunihiro
K
Tanaka
Kuniaki
K
Hamamoto
Makoto
M
Yamamoto
Hideki
H
Matsubayashi
Takeyuki
T
Yoshida
Hiroshi
H
Toji
Hiromasa
H
Nakamura
Shigenobu
S
Hirai
Shunsaku
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000134:cerebrospinal fluid / Q000378:metabolism; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000453:epidemiology; D000704:Analysis of Variance; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002648:Child; D003704:Dementia / Q000134:cerebrospinal fluid* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016875:tau Proteins / Q000134:cerebrospinal fluid*
D015415:Biomarkers; D016875:tau Proteins