title: Losartan-induced hepatic injury.
abstract: Losartan, an angiotensin II receptor antagonist, is widely used for the treatment of hypertension. Clinical experience with this drug has demonstrated that it is safe. Losartan-induced hepatic toxicity is extremely rare. We report a case of severe hepatic toxicity and fibrosis caused by losartan use, and we review four previously reported cases. Drug-induced hepatic injury may be seen during the treatment of hypertension by losartan and the clinician should be aware of this toxicity, especially during the initial phase of treatment.
authors.affiliation: Department of Clinical Bacteriology and Infectious Diseases, Cerrahpasa Medical Faculty, Istanbul University, Beylerbeyi 81210 Istanbul, Turkey. fehmitabak@hotmail.com
authors.forename: Fehmi
authors.initials: F
authors.lastname: Tabak
authors.forename: Ali
authors.initials: A
authors.lastname: Mert
authors.forename: Resat
authors.initials: R
authors.lastname: Ozaras
authors.forename: Mithat
authors.initials: M
authors.lastname: Biyikli
authors.forename: Recep
authors.initials: R
authors.lastname: Ozturk
authors.forename: Gulsen
authors.initials: G
authors.lastname: Ozbay
authors.forename: Hakan
authors.initials: H
authors.lastname: Senturk
authors.forename: Yildirim
authors.initials: Y
authors.lastname: Aktuglu
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced*; D019808:Losartan / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents; D019808:Losartan