The role of met-enkephalin in silent myocardial ischemia in diabetic patients.
Met-enkephalin plasma levels were evaluated in 20 cardioischemic diabetic patients. All the patients had ECG ischemic signs. Ten patients with diabetic autonomic neuropathy, experienced no pain during myocarial ischemia. Met-enkephalin levels in the diabetic patients with silent myiocardial ischemia were significantly lower compared to those in the symptomatic patients. This demonstrates that the absence of myocardial ischemic pain in neuropathic diabetic patients is not accounted for by met-enkephalin action.
Parlapiano
C
C
Dipartimento di Scienze Cliniche, Endocrinologia, Policlinico Umberto I Università degli Studi di Roma La Sapienza, Roma, Italy. Papitebe@hotmail.com
Borgia
M C
MC
Tonnarini
G
G
Campana
E
E
Giancaspro
G
G
Pantone
P
P
Giovanniello
T
T
Cardarelli
G
G
Vincentelli
G M
GM
Alegiani
F
F
Negri
M
M
D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000097:blood / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology; D004744:Enkephalin, Methionine / Q000097:blood / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000503:physiopathology*
D004744:Enkephalin, Methionine