title: Nucleolar organizer regions in laryngeal cancer.
abstract: The purpose of this study was to estimate the prognostic value of the AgNORs count per nucleus in laryngeal cancer. The sections of diagnostic, formalin-fixed and paraffin-embedded specimens from 48 patients with T1-4 tumours were stained with silver nitrate for visualization of NORs (AgNORs). The correlation between AgNORs score and tumour clinicopathological features was estimated. The mean AgNOR number per nucleus was 2.73 +/- 0.87 (range 1.48-4.38). The AgNOR counts did not correlate with the stage of the disease, patient survival rate and N stage. A significant correlation between the mean AgNORs number and various stages of histological differentiation of carcinoma was observed (p < 0.05).
authors.affiliation: Otolaryngology Department, Medical University of Lublin.
authors.forename: J
authors.initials: J
authors.lastname: Klatka
authors.forename: D
authors.initials: D
authors.lastname: Skomra
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009697:Nucleolus Organizer Region / Q000473:pathology*; D011379:Prognosis