title: Surfactant therapy in infants and children: three years experience in a pediatric intensive care unit.
abstract: Despite the established success of surfactant application in neonates, the use of surfactant in older children is still a matter of discussion. We hypothesized that surfactant application in children with acute respiratory distress syndrome (ARDS) secondary to a pulmonary or systemic disease or after cardiac surgery improves pulmonary function. We also asked whether repeated treatment could further improve pulmonary function. To answer these questions, we measured oxygenation index (OI) and hypoxemia score after the first and after a second application of surfactant (50-100 mg/kg body wt) at least 24 h later. We enrolled 19 children (older than 4 weeks) for a retrospective chart review study, and six of them underwent cardiac surgery. Demographic data were extracted. OI and hypoxemia score were estimated before and 2 and 24 h after surfactant application. Lung injury score was calculated before and 24 h after surfactant application. Outcome measures included survival, duration of mechanical ventilation, and pediatric ICU and hospital stay. The median patient age was 9.0 (quarter percentile 3.7/25) months. The median weight was 8.4 (4.1/11.5) kg. The median lung injury score before the first surfactant application was 2.3 (2.3/2.6). Hospital duration and pediatric ICU stay for all patients was 31.0 (20.0/49.5) days and 27.0 (15.5/32.5) days, respectively. The duration of mechanical ventilation was 24.0 (18.5/31.0) days. The overall mortality was 53%. Twenty-four hours after the first surfactant application, pulmonary function significantly improved. The median OI was 14 (5.5/26) before and 7 (4.5/14.5) 24 h after surfactant application (P= 0.027). The hypoxemia score was 91.7 (69.9/154.2) before and 148.4 (99.2/167.6) 24 h after surfactant application (P = 0.0026). Seven children received a second application, which did not further improve pulmonary function. The lung injury score was not influenced by either surfactant application. We conclude that a single surfactant application improves pulmonary function in children with ARDS. A second application of surfactant showed no further benefit. Outcome was not affected in our study population.
authors.affiliation: Department of Neonatology and Paediatric Intensive Care, University Children's Hospital, University of Vienna, Austria.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Hermon
authors.forename: Johann
authors.initials: J
authors.lastname: Golej
authors.forename: Gudrun
authors.initials: G
authors.lastname: Burda
authors.forename: Harald
authors.initials: H
authors.lastname: Boigner
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Stoll
authors.forename: Klara
authors.initials: K
authors.lastname: Vergesslich
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Strohmaier
authors.forename: Arnold
authors.initials: A
authors.lastname: Pollak
authors.forename: Gerhard
authors.initials: G
authors.lastname: Trittenwein
mesh_terms: D001317:Austria; D001688:Biological Products; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D008055:Lipids / Q000008:administration & dosage / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010743:Phospholipids; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000627:therapeutic use*; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D012129:Respiratory Function Tests; D012189:Retrospective Studies
chemical_list: D001688:Biological Products; D008055:Lipids; D010743:Phospholipids; D011663:Pulmonary Surfactants; C078272:SF-RI 1, bovine surfactant preparation; C068291:poractant alfa