title: Calix[4]arenes linked to multiple bidentate N-donors: potential ligands for synthetic modeling of multinuclear metalloenzymes.
abstract: A series of calix[4]arenes incorporating three or four bidentate diamines or pyridylamines attached at the "upper rim" were synthesized via practical protocols. Proof of structure was obtained in one instance by X-ray crystallography. These molecules are designed for general use as ligands for the preparation of multinuclear active site models of metalloenzymes. [reaction: see text]
authors.affiliation: Department of Chemistry, Center for Metals in Biocatalysis, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN 55455, USA.
authors.forename: Douglas J E
authors.initials: DJ
authors.lastname: Spencer
authors.forename: Bryan J
authors.initials: BJ
authors.lastname: Johnson
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Johnson
authors.forename: William B
authors.initials: WB
authors.lastname: Tolman
mesh_terms: D000478:Alkylation; D047250:Calixarenes; D018360:Crystallography, X-Ray; D004798:Enzymes / Q000737:chemistry*; D008024:Ligands; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D008667:Metalloproteins / Q000737:chemistry*; D008958:Models, Molecular; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014019:Tissue Donors
chemical_list: D004798:Enzymes; D008024:Ligands; D046911:Macromolecular Substances; D008667:Metalloproteins; D047250:Calixarenes