title: [A case of loxoprofen-induced pneumonitis pathologically resembling hypersensitivity pneumonitis].
abstract: A 66-year-old woman was admitted to our hospital because of high fever, general fatigue, hypoxemia and liver dysfunction. Chest radiographs showed diffuse interstitial shadows in both lungs. We suspected drug-induced pneumonitis because of her history of drug administration for upper respiratory infection. Her symptoms and findings were markedly decreased by discontinuation of the drugs. Transbronchial lung biopsy specimens showed infiltration of eosinophils and lymphocytes to the alveolar septa, granuloma with Langhans' giant cells, and Masson bodies in a manner suggestive of hypersensitivity pneumonitis. Drug lymphocyte stimulation tests were negative except for loxoprofen. There was no recurrence of systemic or respiratory symptoms during overnight stays at home. On the basis of these findings, we arrived at a diagnosis of drug-induced pneumonitis caused by loxoprofen.
authors.affiliation: First Department of Internal Medicine, School of Medicine, University of the Ryukyus, Nishihara-cho, Uehara 207, Okinawa 903-0215, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Tohyama
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Tamaki
authors.forename: Masato
authors.initials: M
authors.lastname: Toyama
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Ishimine
authors.forename: Akiko
authors.initials: A
authors.lastname: Miyazato
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakamoto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Miyara
authors.forename: Futoshi
authors.initials: F
authors.lastname: Higa
authors.forename: Masao
authors.initials: M
authors.lastname: Tateyama
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kawakami
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Saito
mesh_terms: D000368:Aged; D000542:Alveolitis, Extrinsic Allergic / Q000473:pathology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010666:Phenylpropionates / Q000009:adverse effects*; D011014:Pneumonia / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; C040656:loxoprofen