title: Donation of stem cells from blood or bone marrow: results of a randomised study of safety and complaints.
abstract: Biological consequences and physical complaints were compared for donors randomly assigned either to blood stem cell (BSC) or bone marrow (BM) donation. In the period 1994-1999, 61 consecutive donors were included. The BSC donors were given G-CSF 10 microg/kg s.c., daily during 5 days before the first leukapheresis. Nineteen donors had one leukapheresis, 10 required two and one donor needed three leukaphereses in order to reach the target cell number of 2 x 10(6) CD34(+) cells/kg bw of the recipient. A median platelet nadir of 102 x 10(9)/l was reached shortly after the last leukapheresis. Three weeks post harvest, 17 of 30 BSC donors had a mild leukopenia. Six had a leukopenia lasting more than a year before returning to normal values. Both groups were monitored prospectively through a standardised questionnaire completed by the donors. BSC donation was significantly less burdensome than BM donation and was preferred by the donors. The short-term risks of BSC mobilisation and harvest seem negligible. The potential long-term effects of G-CSF are unresolved and the donors must be followed closely.
authors.affiliation: Medical Department, Rikshospitalet University Hospital, 0027 Oslo, Norway.
authors.forename: D
authors.initials: D
authors.lastname: Heldal
authors.forename: L
authors.initials: L
authors.lastname: Brinch
authors.forename: G
authors.initials: G
authors.lastname: Tjønnfjord
authors.forename: B G
authors.initials: BG
authors.lastname: Solheim
authors.forename: T
authors.initials: T
authors.lastname: Egeland
authors.forename: G
authors.initials: G
authors.lastname: Gadeholt
authors.forename: D
authors.initials: D
authors.lastname: Albrechtsen
authors.forename: G
authors.initials: G
authors.lastname: Aamodt
authors.forename: S A
authors.initials: SA
authors.lastname: Evensen
mesh_terms: D000293:Adolescent; D000328:Adult; D001772:Blood Cell Count; D004334:Drug Administration Schedule; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects; D019650:Hematopoietic Stem Cell Mobilization / Q000009:adverse effects / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007937:Leukapheresis; D007970:Leukopenia / Q000097:blood / Q000209:etiology / Q000473:pathology; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D020858:Tissue and Organ Harvesting / Q000009:adverse effects* / Q000379:methods
chemical_list: D016179:Granulocyte Colony-Stimulating Factor