title: Electron beam computed tomography and ventilation perfusion scintigraphy in the diagnosis of pulmonary embolism.
abstract: The purpose of this study, performed in patients with suspected pulmonary embolism (PE), was to compare V/Q scans and electron beam computed tomography (CT) scans on a patient-by-patient and segment-by-segment basis. Both a segment-based and a lobe-based analysis was performed in those patients positive for PE. The diagnosis of PE was assumed on the basis of a mismatch at V/Q scanning or a filling defect in a pulmonary vessel at contrast-enhanced electron beam CT. In 37/45 patients (24 female, 21 male, 58+/-16 years) with suspected PE, the diagnosis of PE was confirmed or excluded by both modalities, resulting in a correlation of 82% between electron beam CT and V/Q scanning. In the 28 patients positive for PE according to one or both modalities, 504 segments were evaluated. Of these 504 segments, 248 (nearly 50%) showed perfusion defects on V/Q scans, of which only 90 (36%) displayed emboli at electron beam CT. Overall, a total of only 135 of the 504 segments (27%) were abnormal at electron beam CT. More than 50% of the patients with discrepant results did not show an embolus at electron beam CT. It is concluded that there is a good correlation (82%) between V/Q scanning and electron beam CT on a patient-by-patient basis but a markedly less good correlation (62%) in a segment-based analysis.
authors.affiliation: Clinic for Nuclear Medicine, Charité Medical School, Humboldt University of Berlin, Luisenstrasse 6-8, 10098 Berlin, Germany. beatrice.kettner@charite.de
authors.forename: Beatrice I
authors.initials: BI
authors.lastname: Kettner
authors.forename: Christian N H
authors.initials: CN
authors.lastname: Enzweiler
authors.forename: Dirk
authors.initials: D
authors.lastname: Sandrock
authors.forename: Ingrid
authors.initials: I
authors.lastname: Reisinger
authors.forename: Dieter L
authors.initials: DL
authors.lastname: Munz
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008168:Lung / Q000098:blood supply / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013668:Technetium Tc 99m Aggregated Albumin; D014057:Tomography, X-Ray Computed; D014692:Ventilation-Perfusion Ratio
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin