Cutaneous dissemination of nasal NK/T-cell lymphoma with bone marrow, liver and lung involvement.
We describe a 32-year-old Korean man with a primary nasal natural killer (NK)/T-cell lymphoma (NKTCL). Combination chemotherapy and radiotherapy resulted in initial complete remission. However, cutaneous dissemination to the trunk and proximal extremities occurred 16 months later and further investigations revealed involvement of the liver, lymph nodes, lung and bone marrow. Nasal CD56+ NKTCL is mostly localized to the nasal area but also shows a predilection for other sites, such as skin. Cutaneous dissemination may be an indicator of widespread metastasis to internal organs and is consistently fatal.
Chang
S E
SE
Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, Korea. cse@snu.md
Lee
S Y
SY
Choi
J H
JH
Sung
K J
KJ
Moon
K C
KC
Koh
J K
JK
D000328:Adult; D001706:Biopsy; D019046:Bone Marrow Neoplasms / Q000556:secondary*; D006801:Humans; D007694:Killer Cells, Natural; D008113:Liver Neoplasms / Q000556:secondary*; D008175:Lung Neoplasms / Q000556:secondary*; D016410:Lymphoma, T-Cell, Cutaneous; D008297:Male; D009669:Nose Neoplasms / Q000473:pathology; D012878:Skin Neoplasms / Q000556:secondary*