Effective enzymatic resolution of rac-1-(3-trifluoromethylphenyl)propan-2-ol, precursor of fenfluramine.
Lipases from Candida antarctica and from Mucor miehei efficiently catalyze the enantioselective esterification of rac-1-(3-trifluoromethylphenyl)propan-2-ol. The obtained enantioforms are suitable to prepare both enantiomers of fenfluramine.
D'Antona
Nicola
N
Istituto CNR per lo Studio delle Sostanze Naturali di Interesse Alimentare e Chimico-farmaceutico, Via del Santuario 110, 95028 Valverde CT, Italy.
Mangiafico
Sebastiano
S
Nicolosi
Giovanni
G
D000818:Animals; D002175:Candida / Q000201:enzymology; D004951:Esterification; D005277:Fenfluramine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D066298:In Vitro Techniques; D008049:Lipase; D009089:Mucor / Q000201:enzymology; D011355:Prodrugs / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D013237:Stereoisomerism
D005277:Fenfluramine; D008049:Lipase; D011355:Prodrugs; D017367:Selective Serotonin Reuptake Inhibitors; C037762:1-(3-trifluoromethylphenyl)-2-propanol