gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?
Sisodia
Sangram S
SS
Center for Molecular Neurobiology, Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA.
St George-Hyslop
Peter H
PH
D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D051880:Receptors, Notch; D015534:Trans-Activators / Q000378:metabolism
D016229:Amyloid beta-Peptides; D008565:Membrane Proteins; D051880:Receptors, Notch; D015534:Trans-Activators; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human