title: Bifunctional asymmetric catalysis: a tandem nucleophile/Lewis acid promoted synthesis of beta-lactams.
abstract: [reaction: see text]. We describe a superior procedure for the catalytic, asymmetric synthesis of beta-lactams using a bifunctional catalyst system consisting of a chiral nucleophile and an achiral Lewis acid.
authors.affiliation: Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
authors.forename: Stefan
authors.initials: S
authors.lastname: France
authors.forename: Harald
authors.initials: H
authors.lastname: Wack
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Hafez
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Taggi
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Witsil
authors.forename: Thomas
authors.initials: T
authors.lastname: Lectka
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002384:Catalysis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry; D013237:Stereoisomerism; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D008670:Metals; D047090:beta-Lactams