title: Recovery of injured adrenal medulla by differentiation of pre-existing undifferentiated chromaffin cells.
abstract: We described previous that the adrenal medulla recovers rapidly from the injuries due to salinomycin. In the present study we found the recovery to be apparently due to differentiation of pre-existing, primitive undifferentiated, chromaffin cells, rather than mitosis, as evidenced by lack of incorporation of 5-bromo-2-deoxyuridine in the differentiating and/or differentiated chromaffin cells. Electron-dense, striated fibrils observed within the necrotic cells and in the extracellular space were presumed to be intermediate degradation products. Schwann cells actively functioned as phagocytes in this study, and seemed to indirectly stimulate the differentiation of undifferentiated chromaffin cells.
authors.affiliation: Department of Veterinary Anatomy, Faculty of Agriculture, The University of Tokyo, Japan. ijpan@brs.nihou-u.ac.jp
authors.forename: Cleo
authors.initials: C
authors.lastname: Chen-Pan
authors.forename: In Jen
authors.initials: IJ
authors.lastname: Pan
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Hans H C
authors.initials: HH
authors.lastname: Chen
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D000313:Adrenal Medulla / Q000473:pathology*; D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002454:Cell Differentiation; D019439:Chromaffin Cells / Q000502:physiology* / Q000648:ultrastructure; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D017207:Rats, Sprague-Dawley; D012583:Schwann Cells / Q000648:ultrastructure
chemical_list: D001973:Bromodeoxyuridine