title: Management of carotid body paragangliomas and review of a 30-year experience.
abstract: Carotid body tumors are rare neoplasms and must be considered in the evaluation of all lateral neck masses; early surgical removal has been recommended. In this study, the medical records of 29 patients with 34 carotid body paragangliomas who were treated at our institution between 1971 and 2001 were retrospectively reviewed. An overview is provided of this lesion, including diagnosis, classification, metastatic potential, possible secretory function, operative techniques, and nonsurgical methods of management. Carotid body tumors may be familial and are more often bilateral in these instances; five patients (17%) had bilateral tumors in this series. The criterion for malignancy is demonstrated by metastatic tumor in lymph nodes or distant organs. Three patients (10%) had malignant tumors, one with hepatic metastases. One patient (3%) in our series exhibited abnormal serotonin production. Vascular reconstruction was necessary in eight cases (28%). No stroke occurred, however, two arterial thromboses (7%), five permanent cranial nerve deficits (17%), and one death (3%) from massive pulmonary embolism were seen. Our experience demonstrates that early operative management is warranted to avoid the possibility of eventual metastasis and progressive local invasion to the point of inoperability.
authors.affiliation: Department of Surgery, Division of Vascular Surgery, Baylor University Medical Center, Dallas, TX, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Patetsios
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Gable
authors.forename: Wilson V
authors.initials: WV
authors.lastname: Garrett
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Lamont
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Kuhn
authors.forename: William P
authors.initials: WP
authors.lastname: Shutze
authors.forename: Harry
authors.initials: H
authors.lastname: Kourlis
authors.forename: Bradley
authors.initials: B
authors.lastname: Grimsley
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Pearl
authors.forename: Bertram L
authors.initials: BL
authors.lastname: Smith
authors.forename: C M
authors.initials: CM
authors.lastname: Talkington
authors.forename: Jesse E
authors.initials: JE
authors.lastname: Thompson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019917:Blood Vessel Prosthesis Implantation; D002345:Carotid Body Tumor / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010235:Paraganglioma / Q000175:diagnosis / Q000556:secondary / Q000601:surgery*; D011138:Polytetrafluoroethylene / Q000627:therapeutic use; D012189:Retrospective Studies; D012501:Saphenous Vein / Q000637:transplantation; D016896:Treatment Outcome
chemical_list: D011138:Polytetrafluoroethylene