title: Pharmacokinetics of piperacillin-tazobactam in anuric intensive care patients during continuous venovenous hemodialysis.
abstract: The pharmacokinetics of piperacillin-tazobactam were investigated in eight anuric intensive care patients treated by continuous venovenous hemodialysis (CVVHD). The elimination half-life of piperacillin was 4.3 +/- 1.2 h, and that of tazobactam was 5.6 +/- 1.3 h. The contribution of CVVHD to the overall elimination was relevant (>25%) for both drugs.
authors.affiliation: Department of Clinical Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Rostock, D-18057 Rostock, Germany. silke.mueller@med.uni-rostock.de
authors.forename: Silke C
authors.initials: SC
authors.lastname: Mueller
authors.forename: Jolanta
authors.initials: J
authors.lastname: Majcher-Peszynska
authors.forename: Heiko
authors.initials: H
authors.lastname: Hickstein
authors.forename: Astrid
authors.initials: A
authors.lastname: Francke
authors.forename: Annette
authors.initials: A
authors.lastname: Pertschy
authors.forename: Martin
authors.initials: M
authors.lastname: Schulz
authors.forename: Ralf
authors.initials: R
authors.lastname: Mundkowski
authors.forename: Bernd
authors.initials: B
authors.lastname: Drewelow
mesh_terms: D000328:Adult; D000368:Aged; D001002:Anuria / Q000628:therapy*; D004359:Drug Therapy, Combination / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010878:Piperacillin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000077725:Piperacillin, Tazobactam Drug Combination; D006435:Renal Dialysis / Q000379:methods*
chemical_list: D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin