title: The impact of incident vertebral and non-vertebral fractures on health related quality of life in postmenopausal women.
abstract: BACKGROUND
  Little empirical research has examined the multiple consequences of osteoporosis on quality of life.
  
  
  METHODS
  Health related quality of life (HRQL) was examined in relationship to incident fractures in 2009 postmenopausal women 50 years and older who were seen in consultation at our tertiary care, university teaching hospital-affiliated office and who were registered in the Canadian Database of Osteoporosis and Osteopenia (CANDOO) patients. Patients were divided into three study groups according to incident fracture status: vertebral fractures, non-vertebral fractures and no fractures. Baseline assessments of anthropometric data, medical history, therapeutic drug use, and prevalent fracture status were obtained from all participants. The disease-targeted mini-Osteoporosis Quality of Life Questionnaire (mini-OQLQ) was used to measure HRQL.
  
  
  RESULTS
  Multiple regression analyses revealed that subjects who had experienced an incident vertebral fracture had lower HRQL difference scores as compared with non-fractured participants in total score (-0.86; 95% confidence intervals (CI): -1.30, -0.43) and the symptoms (-0.76; 95% CI: -1.23, -0.30), physical functioning (-1.12; 95% CI: -1.57, -0.67), emotional functioning (-1.06; 95% CI: -1.44, -0.68), activities of daily living (-1.47; 95% CI: -1.97, -0.96), and leisure (-0.92; 95% CI: -1.37, -0.47) domains of the mini-OQLQ. Patients who experienced an incident non-vertebral fracture had lower HRQL difference scores as compared with non-fractured participants in total score (-0.47; 95% CI: -0.70, -0.25), and the symptoms (-0.25; 95% CI: -0.49, -0.01), physical functioning (-0.39; 95% CI: -0.65, -0.14), emotional functioning (-0.97; 95% CI: -1.20, -0.75) and the activities of daily living (-0.47; 95% CI: -0.73, -0.21) domains.
  
  
  CONCLUSIONS
  Quality of life decreased in patients who sustained incident vertebral and non-vertebral fractures.
authors.affiliation: Department of Medicine, St, Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada. jd.adachi@sympatico.ca
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Adachi
authors.forename: George
authors.initials: G
authors.lastname: Ioannidis
authors.forename: Wojciech P
authors.initials: WP
authors.lastname: Olszynski
authors.forename: Jacques P
authors.initials: JP
authors.lastname: Brown
authors.forename: David A
authors.initials: DA
authors.lastname: Hanley
authors.forename: Rolf J
authors.initials: RJ
authors.lastname: Sebaldt
authors.forename: Annie
authors.initials: A
authors.lastname: Petrie
authors.forename: Alan
authors.initials: A
authors.lastname: Tenenhouse
authors.forename: Gregory F
authors.initials: GF
authors.lastname: Stephenson
authors.forename: Alexandra
authors.initials: A
authors.lastname: Papaioannou
authors.forename: Gordon H
authors.initials: GH
authors.lastname: Guyatt
authors.forename: Charlie H
authors.initials: CH
authors.lastname: Goldsmith