Intrathecal administration of 5-HT(3) receptor agonist modulates jaw muscle activity evoked by injection of mustard oil into the temporomandibular joint in the rat.
The effect of intrathecal administration of the 5-HT(3) receptor agonist 2-methyl-5-hydroxytryptamine (2m-5HT) on jaw muscle activity evoked by mustard oil (MO) injection into the temporomandibular joint of anesthetized rats was examined. One microgram or 100 microg of 2m-5HT significantly enhanced or suppressed jaw muscle responses, respectively. Pre-administration of tropisetron, a 5-HT(3) receptor antagonist, attenuated the effect of 2m-5HT. These results indicate that activation of 5-HT(3) receptors can modulate trigeminal nociceptive responses.
Seo
Kenji
K
Division of Dental Anesthesiology, Department of Tissue Regeneration and Reconstruction, Niigata University Dental Hospital, 2-5274 Gakkocho-dori, Niigata City, 951-8514, Japan. seo@dent.niigatta-u.ac.jp
Fujiwara
Naoshi
N
Hu
James W
JW
Cairns
Brian E
BE
Someya
Genji
G
D000344:Afferent Pathways / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions / Q000502:physiology; D004525:Efferent Pathways / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D004576:Electromyography; D007211:Indoles / Q000494:pharmacology; D008297:Male; D008410:Masticatory Muscles / Q000294:innervation / Q000502:physiology*; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009149:Mustard Plant; D009475:Neurons, Afferent / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009619:Nociceptors / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology; D010938:Plant Oils; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000031:analogs & derivatives* / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D013704:Temporomandibular Joint / Q000187:drug effects / Q000294:innervation* / Q000503:physiopathology; D014275:Trigeminal Caudal Nucleus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000077526:Tropisetron
D007211:Indoles; D010936:Plant Extracts; D010938:Plant Oils; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D012701:Serotonin; D000077526:Tropisetron; C045918:2-methyl-5-HT; C027793:mustard oil