title: Nitric oxide release from coumarin 4-carboxamidoximes in the presence of thiols.
abstract: Coumarin 4-carboxamides with potent anti-inflammatory activity were studied for nitric oxide release in the presence of thiol cofactors in vitro. It was found that NO2- release was dependent on the nature of thiol.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Christos A
authors.initials: CA
authors.lastname: Kontogiorgis
authors.forename: Dimitra J
authors.initials: DJ
authors.lastname: Hadjipavlou-Litina
mesh_terms: D003374:Coumarins / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry*; D026423:S-Nitroso-N-Acetylpenicillamine / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D003374:Coumarins; D020030:Nitric Oxide Donors; D013438:Sulfhydryl Compounds; D009569:Nitric Oxide; D026423:S-Nitroso-N-Acetylpenicillamine; D003545:Cysteine