Radioprotective effects of 2-iminothiazolidine derivatives against lethal doses of gamma radiation in mice.
Although thiol-containing compounds have long been known to possess radioprotective properties, their therapeutics utility is limited by their side effects at radioprotective doses. In this study, a series of 2-iminothiazolidine derivatives were prepared and their toxicity and radioprotective effects in NMRI mice were determined using the LD50/30 end point. The LD50 values, as determined by a Probit analysis, were between 11 and 14 mg/kg. For studying radioprotective effects, one-sixth of the toxic LD50 values were used, namely 2 and 2.2 mg/kg. To evaluate the radioprotective capabilities, mice were exposed to lethal doses of cobalt-60 gamma-radiation alone or in the presence of compounds. The percentage survival of mice at 30 days for these compounds compared to control mice were 10 to 30% when injected 15 and 30 minutes before gamma-irradiation. They were significant compared to the control group (P < 0.05). 2-Imino-3-(benzoylmethyl)thiazolidine derivatives showed different radioprotective effects when injected at different times before irradiation, but were not statistically significant from each other (P > 0.05).
Hosseinimehr
S J
SJ
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Shafiee
A
A
Mozdarani
H
H
Akhlagpour
S
S
D000818:Animals; D005720:Gamma Rays; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D013844:Thiazoles; C015674:2-amino-delta(2)-thiazoline-4-carboxylic acid