Investigations on the antinociceptive activity of crude extracts from Croton cajucara leaves in mice.
The crude leaf extracts of Croton cajucara Benth. were studied for their antinociceptive property in chemical and thermal models of nociception in mice. All the tested extracts (hexanic, chloroformic and methanolic), at oral doses of 100 and 200 mg/kg demonstrated significant inhibition of acetic acid-induced writhing and the second phase response of formalin, but did not manifest a significant effect in hot-plate test.
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Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Caixa Postal-3157, 60430-270, Fortaleza, CE, Brazil.
Albuquerque
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Maciel
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D019342:Acetic Acid; D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D019665:Euphorbiaceae; D005557:Formaldehyde; D006358:Hot Temperature; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D010147:Pain Measurement / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
D000700:Analgesics; D010936:Plant Extracts; D005557:Formaldehyde; D019342:Acetic Acid