title: [An elderly case of microscopic polyangiitis following bronchial asthma].
abstract: A 78-year-old woman who had bronchial asthma for 15 years developed dysesthesia, neuralgia, muscle weakness and atrophy in both feet and her left hand. Prednisolone (maximum dose 80 mg) was not effective, and she displayed gait disturbance. Laboratory findings showed leukocytosis (neutrophils dominant), renal dysfunction, elevation of CRP and positive P-ANCA. Biopsy revealed vasculitis, and reduced density of myelinated fibers. Although steroid pulse therapy improved neuralgia and renal dysfunction, severe disability of motor function and sensory disturbance still remained. Vasculitis syndrome following bronchial asthma indicated Churg-Strauss syndrome (CSS), while severe renal dysfunction and lack of eosinophilia were symptoms compatible with microscopic polyangiitis (MPA). The present case showed properties of both MPA and CSS.
authors.affiliation: Department of Neurology, Mifukai Vihara Hananosato Hospital.
authors.forename: Masaya
authors.initials: M
authors.lastname: Oda
authors.forename: Yuishin
authors.initials: Y
authors.lastname: Izumi
authors.forename: Takafumi
authors.initials: T
authors.lastname: Miyachi
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Ochi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Hijiri
authors.initials: H
authors.lastname: Ito
authors.forename: Sadao
authors.initials: S
authors.lastname: Katayama
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D001249:Asthma / Q000150:complications*; D015267:Churg-Strauss Syndrome / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009443:Neuritis / Q000209:etiology; D014657:Vasculitis / Q000209:etiology* / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic