title: Prevention of human deconditioning during prolonged immersion in water.
abstract: A 56-day immersion experiment in which two subjects participated was carried out. During the experiment the preventive effect of periodic acceleration combined with exercise and water-salt intake was assessed. Simulating an increased gravitational field, exposure to acceleration increased the static component of the load upon the musculo-skeletal system, increased the gradient of the blood hydrostatic pressure, activated mechanisms responsible for the venous return to the heart, stimulated systems regulating antidiuretic and antisodiumdiuretic reflexes. Involvement of these mechanisms restored haemodynamic parameters, fluid-electrolyte balance and blood coagulability. The prophylactic effect of acceleration was enhanced if combined with exercise and supplemented water-salt intake.
authors.affiliation: Institute of Biomedical Problems, Moscow, USSR.
authors.forename: E B
authors.initials: EB
authors.lastname: Shulzhenko
authors.forename: I F
authors.initials: IF
authors.lastname: Vil-Vilyams
authors.forename: A I
authors.initials: AI
authors.lastname: Grigoryev
authors.forename: K I
authors.initials: KI
authors.lastname: Gogolev
authors.forename: M A
authors.initials: MA
authors.lastname: Khudyakova
mesh_terms: D000054:Acceleration; D001810:Blood Volume / Q000187:drug effects / Q000502:physiology; D002118:Calcium / Q000378:metabolism / Q000652:urine; D002498:Centrifugation; D003404:Creatinine / Q000378:metabolism / Q000652:urine; D005081:Exercise Therapy; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D018471:Hypergravity; D007101:Immersion / Q000009:adverse effects*; D008297:Male; D011188:Potassium / Q000378:metabolism / Q000652:urine; D012965:Sodium Chloride / Q000627:therapeutic use* / Q000652:urine; D014867:Water; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology; D018544:Weightlessness Countermeasures; D018474:Weightlessness Simulation / Q000009:adverse effects*
chemical_list: D014867:Water; D012965:Sodium Chloride; D003404:Creatinine; D011188:Potassium; D002118:Calcium