Clathriol, a novel polyoxygenated 14beta steroid isolated from the New Zealand marine sponge Clathria lissosclera.
Clathriol (1), a highly oxygenated steroid with the unusual 14beta configuration, was isolated from the New Zealand marine sponge Clathria lissosclera. The structure was elucidated from a combination of NMR and mass spectroscopy. Clathriol showed in vitro antiinflammatory activity against human neutrophyl and rat mast cells.
Keyzers
Robert A
RA
School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.
Northcote
Peter T
PT
Webb
Vicky
V
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D006636:Histamine Release / Q000187:drug effects; D008407:Mast Cells / Q000187:drug effects; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D051381:Rats; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D013256:Steroids; C457247:clathriol