title: Development of models to predict dose of pesticides in professional turf applicators.
abstract: Epidemiologic studies designed to assess the chronic effects of pesticides are limited by inadequate measurements of exposures. Although cohort studies have been initiated to evaluate the effects of 2,4-dichlorophenoxyacetic acid (2,4-D) and other pesticides in professional turf applicators, they may have limited power to detect significant health risks and may be subject to bias from exposure measurement error. In this study, the doses of 2,4-D, mecoprop [2-(4-chloro-2 methylphenoxy) propionic acid, MCPP] and dicamba (3,6-dichloro-o-anisic acid) were evaluated in a group of 98 professional turf applicators from 20 companies across southwestern Ontario. During a 1-week period (Saturday to Thursday), the volume of pesticide (active ingredient) applied was only weakly related to the total dose of 2,4-D absorbed (R(2)=0.21). Two additional factors explained a large proportion of variation in dose: the type of spray nozzle used and the use of gloves while spraying. Individuals who used a fan-type nozzle had significantly higher doses than those who used a gun-type nozzle. Glove use was associated with significantly lower doses. Job satisfaction and current smoking influenced the dose but were not highly predictive. In the final multiple regression models predicting total absorbed dose of 2,4-D and mecoprop, approximately 63-68% of the variation was explained. The future application of these models for epidemiologic research will depend on the availability of information and records from employers, the feasibility of contacting study subjects and cost.
authors.affiliation: Department of Public Health Sciences, Graduate Department of Community Health, University of Toronto, Toronto, Ontario, Canada. saharris@mail1.vcu.edu
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Harris
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Sass-Kortsak
authors.forename: Paul N
authors.initials: PN
authors.lastname: Corey
authors.forename: James T
authors.initials: JT
authors.lastname: Purdham
mesh_terms: D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000032:analysis* / Q000652:urine; D000328:Adult; D000383:Agriculture; D003996:Dicamba / Q000032:analysis* / Q000652:urine; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring / Q000379:methods / Q000592:standards*; D005260:Female; D006540:Herbicides / Q000032:analysis* / Q000652:urine; D006801:Humans; D008297:Male; D015233:Models, Statistical; D016273:Occupational Exposure / Q000032:analysis*; D011237:Predictive Value of Tests; D012044:Regression Analysis; D011795:Surveys and Questionnaires
chemical_list: D006540:Herbicides; D008456:2-Methyl-4-chlorophenoxyacetic Acid; D003996:Dicamba