title: Evaluation of a novel doppler index of combined systolic and diastolic myocardial performance in Newfoundland dogs with familial prevalence of dilated cardiomyopathy.
abstract: A Doppler index of myocardial performance (IMP) has been recently proposed in human cardiology, which is calculated from the isovolumic contraction time (ICT), isovolumic relaxation time (IRT), and the ejection time (ET) using the following formula: (ICT+IRT)/ET. In this study, IMP was measured and evaluated in Newfoundland dogs categorized in four groups: Normal dogs (n = 31), dilated cardiomyopathy (DCM) (n = 34), depressed fractional shortening (dFS) (n = 27), and left ventricular enlargement (LVE) (n = 7). IMP was found to be independent of age, sex, body surface area, and the R-R interval in the Normal group. There were significant differences in IMP between the DCM group and the Normal and dFS groups (P < 0.05) and between Newfoundlands with overt vs. occult DCM. IMP is a Doppler index which appears to correlate with severity of disease and may be of use in the early diagnosis of affected dogs during screening for the presence of DCM.
authors.affiliation: Department of Veterinary Clinical Studies, The Hospital for Small Animals, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush Veterinary Centre, Midlothian, Scotland, UK.
authors.forename: Byeong-Han
authors.initials: BH
authors.lastname: Lee
authors.forename: Joanna
authors.initials: J
authors.lastname: Dukes-McEwan
authors.forename: Anne T
authors.initials: AT
authors.lastname: French
authors.forename: Brendan M
authors.initials: BM
authors.lastname: Corcoran
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000235:genetics / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000235:genetics; D004285:Dogs; D005260:Female; D008297:Male; D009200:Myocardial Contraction; D015995:Prevalence; D014463:Ultrasonography