title: Palladium-catalyzed arylation of ketone enolates: an expeditious entry to tamoxifen-related 1,2,2-triarylethanones.
abstract: [reaction: see text]. After a rigorous study on the effect of several catalytic systems, a simple, high yielding procedure for the preparation of 1,2,2-triarylethanones, skeletal analogues of tamoxifen, is presented. Apart from the economic and environmental advantages involved, this palladium-catalyzed arylation of deoxybenzoin enolates features a lack of ortho-arylation side reactions. In addition, an alternative approach from acetophenones to the target triarylethanone system is also announced.
authors.affiliation: Kimika Organikoa II Saila, Zientzi Fakultatea, Euskal Herriko Unibertsitatea, P.O. Box 644, 48080 Bilbao, Spain.
authors.forename: Fátima
authors.initials: F
authors.lastname: Churruca
authors.forename: Raul
authors.initials: R
authors.lastname: SanMartin
authors.forename: Imanol
authors.initials: I
authors.lastname: Tellitu
authors.forename: Esther
authors.initials: E
authors.lastname: Domínguez
mesh_terms: D000478:Alkylation; D018931:Antineoplastic Agents, Hormonal / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents; D007659:Ketones / Q000737:chemistry; D010165:Palladium; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D018931:Antineoplastic Agents, Hormonal; D007202:Indicators and Reagents; D007659:Ketones; D013629:Tamoxifen; D010165:Palladium