Antitubercular activity of pentacyclic triterpenoids from plants of Argentina and Chile.
Screening of plants from South America for antitubercular activity and subsequent assay-guided fractionation resulted in the isolation and characterization of several pentacyclic triterpenoids. The MIC values of 22 triterpenoids were determined using the radiorespiratory BACTEC assay and range from 8 microM to above 128 microM. The structure-activity relationships are discussed.
Wächter
G A
GA
Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson 85721, USA.
Valcic
S
S
Flagg
M L
ML
Franzblau
S G
SG
Montenegro
G
G
Suarez
E
E
Timmermann
B N
BN
D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001118:Argentina; D002677:Chile; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000995:Antitubercular Agents; D014315:Triterpenes