title: Typhoid fever: pathogenesis and disease.
abstract: Typhoid fever is an infectious disease of global distribution. Although there is a wealth of data on Salmonella typhimurium infection in the mouse and the interaction of this serovar with human cell lines in vitro, there is a relatively small amount of data on S. typhi and the pathogenesis of typhoid fever. In this review we focus on three areas: adherence to and invasion of gut epithelial cells, dissemination to systemic sites, and survival and replication within host cells. In addition, we attempt to put current salmonella research into the context of typhoid fever.
authors.affiliation: Centre for Molecular Microbiology and Infection, Imperial College of Science Technology and Medicine, London, UK.
authors.forename: D
authors.initials: D
authors.lastname: House
authors.forename: A
authors.initials: A
authors.lastname: Bishop
authors.forename: C
authors.initials: C
authors.lastname: Parry
authors.forename: G
authors.initials: G
authors.lastname: Dougan
authors.forename: J
authors.initials: J
authors.lastname: Wain
mesh_terms: D001422:Bacterial Adhesion; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology; D010586:Phagocytes / Q000276:immunology; D012485:Salmonella typhi / Q000235:genetics / Q000472:pathogenicity*; D014435:Typhoid Fever / Q000209:etiology* / Q000635:transmission; D014774:Virulence