Effect of methamphetamine and imipramine on cerebral ischemia-induced hyperactivity in Mongolian gerbils.
Ischemia-induced hyperactivity is recognized several hours after both common carotid arteries' occlusion for 5 min in Mongolian gerbils, and it continues for at least 7 days. The aim of this study is to investigate the possible mechanisms of this abnormal behavior. Methamphetamine (MAP) (1 and 3 mg /kg) was administered for 7 days and imipramine (IMP) (5 and 10 mg/kg) was administered for 7 or 14 days. Bilateral carotid artery was occluded for 5 min 24 h after the last administrations of these drugs. MAP, which had been administered every day for 1 week, showed marked inhibition in the ischemia-induced hyperactivity. However, IMP did not have any effect even though it had been injected every day for 2 weeks. Hippocampal CA1 neuronal changes also appeared in the MAP- and IMP-administered groups. As the dopaminergic neurotransmission is facilitated by the repeated administration of MAP, the ischemia-induced hyperactivity may be related to abnormalities in dopaminergic function. The participation of the other neurotransmitters is also discussed.
Araki
Hiroaki
H
Department of Hospital Pharmacy, Okayama University Medical School, Japan. haraki@md.okayama-u.ac.jp
Yamamoto
Takahiko
T
Kobayashi
Yuri
Y
Futagami
Koujiro
K
Kawasaki
Hiromu
H
Gomita
Yutaka
Y
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D002545:Brain Ischemia / Q000523:psychology*; D017536:Carotid Artery, Common / Q000502:physiology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology; D006948:Hyperkinesis / Q000523:psychology*; D007099:Imipramine / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects
D000929:Antidepressive Agents, Tricyclic; D000697:Central Nervous System Stimulants; D008694:Methamphetamine; D007099:Imipramine