Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?
NKG2D is an activating cell surface receptor expressed on a wide range of immune effector cells including NK cells, NKT cells, gammadelta T cells as well as CD8(+) alphabeta T cells. Recent data indicate two major features: first, that human (MICA, MICB and ULBP) and mouse (Rae1 and H60) NKG2D ligands can be induced and/or upregulated upon cellular distress; and second, that on T cells NKG2D serves as a co-stimulation molecule for TCR triggering, whereas on NK cells NKG2D may act as a primary recognition structure.
Vivier
Eric
E
Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerrannée, Parc Scientifique de Luminy, Case 906, 13288, Cedex 09, Marseille, France. vivier@ciml.univ-mrs.fr
Tomasello
Elena
E
Paul
Pascale
P
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D058851:GPI-Linked Proteins; D015395:Histocompatibility Antigens Class I / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D007694:Killer Cells, Natural / Q000276:immunology; D008024:Ligands; D008213:Lymphocyte Activation; D008565:Membrane Proteins; D051379:Mice; D055655:NK Cell Lectin-Like Receptor Subfamily K; D011971:Receptors, Immunologic / Q000737:chemistry / Q000502:physiology*; D055607:Receptors, Natural Killer Cell; D013601:T-Lymphocytes / Q000276:immunology
D002352:Carrier Proteins; D058851:GPI-Linked Proteins; D015395:Histocompatibility Antigens Class I; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; C527085:KLRK1 protein, human; C527086:Klrk1 protein, mouse; D008024:Ligands; D008565:Membrane Proteins; D055655:NK Cell Lectin-Like Receptor Subfamily K; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell; C423231:ULBP1 protein, human; C423230:ULBP2 protein, human