Water-losing and water-retaining states: role of water channels and vasopressin receptor antagonists.
Alterations in water metabolism are present in conditions such as diabetes insipidus, syndrome of inappropriate antidiuretic hormone secretion, cardiac failure, cirrhosis, and pregnancy. Recent advances in molecular biology have enhanced our understanding of disordered water metabolism in these conditions. This review examines the roles of central vasopressin synthesis and release and collecting duct vasopressin V2 receptor and aquaporin-2 water channel regulation in water-losing and water-retaining states.
Schrier
R W
RW
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA. Robert.Schrler@UCHSC.EDU
Cadnapaphornchai
M A
MA
Umenishi
F
F
D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D020346:Aquaporins / Q000502:physiology; D001834:Body Water / Q000378:metabolism*; D018500:Diabetes Insipidus, Nephrogenic / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005355:Fibrosis / Q000378:metabolism / Q000503:physiopathology; D006333:Heart Failure / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008297:Male; D011247:Pregnancy / Q000378:metabolism; D011248:Pregnancy Complications / Q000378:metabolism / Q000503:physiopathology; D017483:Receptors, Vasopressin / Q000502:physiology; D016387:Women's Health
D065092:Antidiuretic Hormone Receptor Antagonists; D020346:Aquaporins; D017483:Receptors, Vasopressin