title: Synthesis of aminoglycoside-DNA conjugates.
abstract: Development of aminoglycoside-nucleic acid conjugates is presented. Synthesis of a DNA dimer covalently linked to kanamycin and neomycin isothiocyanates has been carried out. The development of such conjugates will help couple the sequence specificity of nucleic acids to the electrostatic/shape complementarity of aminoglycoside antibiotics in binding nucleic acid targets.
authors.affiliation: Laboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC 29634, USA.
authors.forename: I
authors.initials: I
authors.lastname: Charles
authors.forename: Liang
authors.initials: L
authors.lastname: Xue
authors.forename: Dev P
authors.initials: DP
authors.lastname: Arya
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002240:Carbohydrate Sequence; D004247:DNA / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004247:DNA