[Levels and clinical significance of CD44 (intron 9) and CD44v6 in malignant cerebroma].
OBJECTIVE
To investigate the expression of CD44 (intron 9) and CD44v6 in brain neoplasm.


METHODS
CD44 (intron 9) and CD44v6 were detected in malignant meningoma, encephalic glioma, and normal encephalic tissues around the brain noeplasm respectively by using RT-PCR.


RESULTS
The positive expression rate of CD44v6 was 92.86% (26/28) in malignant meningoma and 88.0% (22/25) in encephalic glioma. They were significantly higher than 5.0% (1/20) in normal encephalic tissues (P < 0.01). Mass values of malignant meningoma and encephalic glioma were higher than that of normal encephalic tissues (P < 0.01). The expression of CD44 (intron 9) was higher in malignant meningoma and encephalic glioma than in normal encephalic tissues (P < 0.01).


CONCLUSIONS
Detection of CD44 (intron 9) and CD44v6 might be helpful to the diagnosis of malignant cerebroma.
Gao
Hong
H
Major Laboratory of Congenital Malformative Research, Health Ministry, Second Affiliated Hospital, China Medical University, Shenyang 110004, China.
Chen
Hui
H
Zhang
Zhibo
Z
Jiang
Tao
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006023:Glycoproteins / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis* / Q000235:genetics; D007438:Introns / Q000235:genetics; D008875:Middle Aged; D012333:RNA, Messenger / Q000096:biosynthesis
C112697:CD44v6 antigen; D006023:Glycoproteins; D018960:Hyaluronan Receptors; D012333:RNA, Messenger