Effect of lipase activities of Propionibacterium granulosum and Propionibacterium acnes.
We studied the lipase activities of Propionibacterium granulosum, P. acnes and the suppression of these activities by Jumi-haidoku-to (JHT). Lipase activity of P. acnes biotype III (BIII) was strongest, while that of P. granulosum was faintly expressed. Compared with the control medium, the production of propionic and butyric acids was suppressed by all the tested mediums combined with JHT. The decrease in these acids produced by JHT was significantly higher in P. granulosum than in P. acnes. Although P. acnes BIII may produce a strong effect on acne, the presence of P. granulosum should not be ignored. Further research is required on the correlation between P. acnes and P. granulosum.
Higaki
S
S
Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, Toyama 930-0194, Japan.
Nakamura
M
M
Kitagawa
T
T
Morohashi
M
M
Yamagishi
T
T
D003470:Culture Media / Q000032:analysis; D003864:Depression, Chemical; D003879:Dermatologic Agents / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000096:biosynthesis; D008049:Lipase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020835:Medicine, Kampo; D010936:Plant Extracts / Q000494:pharmacology*; D011424:Propionibacterium / Q000187:drug effects / Q000201:enzymology*; D011425:Propionibacterium acnes / Q000187:drug effects / Q000201:enzymology*
D003470:Culture Media; D003879:Dermatologic Agents; D005230:Fatty Acids, Nonesterified; D010936:Plant Extracts; C466949:jumi-haidoku-to; D008049:Lipase