title: Effect of vancomycin on Staphylococcus epidermidis adherence to poly(methyl methacrylate) intraocular lenses.
abstract: OBJECTIVE
  To study the adherence of Staphylococcus epidermidis in variable loads (10(8) cfu/mL and 10(3) cfu/mL) to poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) and to evaluate the effect of vancomycin treatment on S epidermidis adherence to the IOL.
  
  
  METHODS
  L.V. Prasad Eye Institute, Hyderabad, India.
  
  
  METHODS
  The study was designed in 2 parts. Phase I: Twelve PMMA IOLs were soaked in a solution of S epidermidis, randomized to 10(8) cfu/mL or 10(3) cfu/mL. They were rinsed or rinsed and vortexed and cultured. Phase II: Twelve IOLs were treated with vancomycin (10 mg/mL), randomized to before and after treatment with S epidermidis.
  
  
  RESULTS
  Staphylococcus epidermidis adhered to all portions of the IOL with 10(8) cfu/mL and 10(3) cfu/mL bacterial loads. Treatment with vancomycin reduced S epidermidis adherence.
  
  
  CONCLUSIONS
  Pretreatment of an IOL with vancomycin or a suitable antibiotic agent appears to reduce bacterial adherence to the IOL. Placement of a sustained-release device that could release an antibiotic agent over a specific period, reducing the incidence of postcataract endophthalmitis, should be studied.
authors.affiliation: Smt Kanuri Santhama Retina Vitreous Service, L.V. Prasad Eye Institute, Hyderabad, India. tpd@lvpeye.stph.net
authors.forename: Taraprasad
authors.initials: T
authors.lastname: Das
authors.forename: Savitri
authors.initials: S
authors.lastname: Sharma
authors.forename: Adiraju V
authors.initials: AV
authors.lastname: Muralidhar
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D015169:Colony Count, Microbial; D006801:Humans; D007910:Lenses, Intraocular / Q000382:microbiology*; D019904:Polymethyl Methacrylate; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000502:physiology*; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D019904:Polymethyl Methacrylate