[HIV-suppressive factors].
A number of host and microbial factors have been shown to modulate HIV-1 infection. Their inhibitory effects are either HIV-specific or non-specific, and involve many different kinds of mechanisms. Among anti-HIV host factors are natural ligands or natural antibodies to HIV coreceptors, anti-inflammatory cytokines, interferons and several body fluid components (such as lactoferrin and prostaglandins). Microbial pathogens/factors that may suppress HIV-1 infection include lipopolysaccharide, scrub-typhus rickettsia, human herpesviruses-6 or -7, and GB virus C. While simple application of these HIV-suppressive factors for HIV-infected individuals is not realistic, investigation of mechanisms involved may lead to better understanding of HIV pathogenesis and help establish novel anti-HIV strategy.
Moriuchi
Hiroyuki
H
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences.
Moriuchi
Masako
M
D000818:Animals; D000898:Antibiosis / Q000502:physiology; D016207:Cytokines / Q000502:physiology*; D029407:GB virus C / Q000502:physiology; D015658:HIV Infections / Q000628:therapy / Q000821:virology; D015497:HIV-1 / Q000254:growth & development*; D006564:Herpesviridae / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D007781:Lactoferrin / Q000502:physiology; D012285:Orientia tsutsugamushi / Q000502:physiology; D019707:Receptors, Chemokine / Q000502:physiology*
D016207:Cytokines; D018836:Inflammation Mediators; D019707:Receptors, Chemokine; D007781:Lactoferrin