Semicarbazide-sensitive amine oxidase (SSAO) in the brain.
Semicarbazide-sensitive amine oxidase (SSAO) is widely distributed in almost tissues. However, its presence in brain microvessels is still controversial. The affinity of SSAO towards benzylamine (Bz) is considerably higher than that of monoamine oxidase (MAO). SSAO plays a role in the toxicity of several environmental and endogenous amines. SSAO-mediated production of toxic aldehydes has been proposed to be related to pathophysiological conditions. The most potent of inhibition of SSAO in monkey brain was observed by tricyclic antidepressant drug imipramine, as compared to tetracyclic drug maprotiline or non-cyclic drug nomifensine. An endogenous SSAO modulator in rat brain cytosol after immobilization stress (IMMO) was found and that this inhibitor could be induced by IMMO. SSAO activity in rat brain might be regulated by the level of this inhibitor. Semicarbazide, a SSAO inhibitor, enhances the formation of .OH products of efflux/oxidation due to 1-methyl-4-phenylpyridinium ion (MPP+). The precise physiological functions of SSAO could play an important role in the control of energy balance in adipose tissue. SSAO could play an important role in the regulation of adipocyte homeostasis.
Obata
Toshio
T
Department of Pharmacology, Oita Medical University, Hasama, Japan. tobata@oita-med.ac.jp
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D003600:Cytosol / Q000201:enzymology; D006801:Humans; D008995:Monoamine Oxidase / Q000378:metabolism; D051381:Rats
D006631:Amine Oxidase (Copper-Containing); D008995:Monoamine Oxidase