[Effects of glutamate on transient outward potassium current of dissociated hippocampal neurons in ca1 sector in rats].
The effects of glutamate on the transient outward potassium current of dissociated hippocampal CA(1) neurons of 7-10 d rats were studied by the whole-cell patch clamp technique. It was found that glutamate could block the transient potassium current in a dose- and time-dependent manner. The effect was partly voltage-dependent. These results suggest that glutamate may decrease the membrane conductance of K(+) channels in hippocampal neurons.
Xu
C Q
CQ
Department of Neurology, Central Hospital of Jiangmen District, Jiangmen 529071.
Zhang
Z M
ZM
Xia
Z L
ZL
Wu
C H
CH
Zhou
P A
PA
D000818:Animals; D004594:Electrophysiology; D005260:Female; D005971:Glutamates / Q000494:pharmacology*; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology; D015221:Potassium Channels / Q000502:physiology*; D051381:Rats
D005971:Glutamates; D015221:Potassium Channels