Alzheimer's vaccine: a cure as dangerous as the disease?
Studies in transgenic mouse models of Alzheimer's disease suggested the potential for a vaccine development. However, some patients in the human clinical trials developed symptoms of brain inflammation, demonstrating the high risk of a deliberately induced auto-immune response.
Münch
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Neuroimmunological Cell Biology Unit, Interdisciplinary Center for Clinical Research (IZKF), University of Leipzig, Federal Republic of Germany. mueg@medizin.uni-leipzig.de
Robinson
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SR
D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000627:therapeutic use; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000276:immunology; D023582:Alzheimer Vaccines / Q000009:adverse effects* / Q000627:therapeutic use; D016229:Amyloid beta-Peptides / Q000009:adverse effects / Q000627:therapeutic use; D000818:Animals; D004660:Encephalitis / Q000139:chemically induced*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics / Q000276:immunology
C437846:AN-1792; D000276:Adjuvants, Immunologic; D023582:Alzheimer Vaccines; D016229:Amyloid beta-Peptides