Girdling effect of adynamic cardiomyoplasty in a model of dilated cardiomyopathy.
OBJECTIVE
The potential benefits of adynamic cardiomyoplasty remain unclear. We determined whether unstimulated skeletal muscle wrap alone prevents or attenuates progressive left ventricular dilation in a canine model of congestive heart failure produced by repeated intracoronary infusions of doxorubicin.


METHODS
14 dogs were randomized in to 2 groups, 1 undergoing cardiomyoplasty (CMP group) and 1 that did not (CONT group). Intracoronary doxorubicin was administered weekly for 5 weeks to induce heart failure. Hemodynamic data was obtained before infusion and 5 weeks afterward. Echocardiography was done weekly.


RESULTS
Significant left ventricular dilation was observed in the CONT group--left ventricular end-diastolic diameter increased from 28.9 +/- 2.7 to 38.5 +/- 3.3 mm (p < 0.05). Significant left ventricular dilation was also observed in the CMP group--left ventricular end-diastolic diameter increased from 28.9 +/- 3.3 to 38.0 +/- 4.2 mm (p < 0.05). Dilation was slower in the CMP group than in the CONT group, however. Ejection fraction decreased from 58.0 +/- 13.8 to 29.9 +/- 13.7% in the CONT group, but was preserved from 56.0 +/- 8.8 to 51.9 +/- 10.3% in the CMP group.


CONCLUSIONS
Adynamic cardiomyoplasty reduces ventricular dilation associated with heart failure without exacerbating left ventricular dysfunction.
Ootaki
Yoshio
Y
Department of Surgery, Division II, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuou-ku, Kobe, 650-0017, Japan.
Tsukube
Takuro
T
Okita
Yutaka
Y
D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced / Q000503:physiopathology / Q000601:surgery*; D018421:Cardiomyoplasty / Q000379:methods; D004195:Disease Models, Animal; D004285:Dogs; D004317:Doxorubicin; D004452:Echocardiography; D006333:Heart Failure / Q000139:chemically induced / Q000503:physiopathology; D006439:Hemodynamics
D004317:Doxorubicin