Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination?
When complexed with the catalytic subunit of DNA-dependent protein kinase (DNA-PK(cs)), the recently discovered dsDNA break repair protein named Artemis acquires the ability to open hairpin DNA molecules in vitro. Both genetic and biochemical data point toward a physiological role for this complex as the elusive hairpin-opening activity in V(D)J recombination.
Schlissel
Mark S
MS
Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. mss@uclink4.berkeley.edu
D000818:Animals; D004247:DNA / Q000235:genetics*; D011088:DNA Ligases / Q000235:genetics*; D004254:DNA Nucleotidyltransferases / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins / Q000235:genetics; D004720:Endonucleases; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D011995:Recombination, Genetic / Q000235:genetics*; D045567:VDJ Recombinases; D001618:beta-Lactamases / Q000235:genetics*
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; C499311:RAG2 protein, human; C064655:V(D)J recombination activating protein 2; C064658:RAG-1 protein; D004247:DNA; D051747:DNA-Activated Protein Kinase; C497263:PRKDC protein, human; D017346:Protein Serine-Threonine Kinases; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases; C426344:DCLRE1C protein, human; D004720:Endonucleases; D001618:beta-Lactamases; D011088:DNA Ligases