title: Does dexamethasone with preemptive analgesia improve pediatric tonsillectomy pain?
abstract: OBJECTIVE
  The study goal was to determine whether the combination of dexamethasone with preemptive analgesia has an additive effect in further improving recovery.
  
  
  METHODS
  We conducted a prospective, randomized, double-blinded trial of 50 children undergoing tonsillectomy at a university ambulatory surgery center. One study group received 1 intravenous dose of dexamethasone, and another group received 1 dose of saline solution. All patients received tonsillar fossa injections of ropivacaine plus clonidine before tonsil excision.
  
  
  RESULTS
  The 2 study groups were similar in main outcome measurements. Pain intensity and quality of life were not statistically different between the groups. There was a small trend to less trismus and less cumulative codeine use in the steroid group. Overall, there was a very low incidence of nausea and vomiting in both groups, which may have been due to the preemptive analgesia.
  
  
  CONCLUSIONS
  Dexamethasone does not significantly improve the morbidity of pediatric tonsillectomy when preemptive analgesia with ropivacaine and clonidine is used concurrently.
authors.affiliation: Department of Otorhinolaryngology, Baylor College of Medicine, Houston, Texas, USA. cmgianno@texaschildrenshospital.org
authors.forename: Carla
authors.initials: C
authors.lastname: Giannoni
authors.forename: Sno
authors.initials: S
authors.lastname: White
authors.forename: F Kayser
authors.initials: FK
authors.lastname: Enneking
mesh_terms: D000293:Adolescent; D000577:Amides; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003000:Clonidine; D003907:Dexamethasone / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011229:Preanesthetic Medication; D011788:Quality of Life; D000077212:Ropivacaine; D014068:Tonsillectomy / Q000009:adverse effects*
chemical_list: D000577:Amides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000077212:Ropivacaine; D003907:Dexamethasone; D003000:Clonidine