BMP signalling: visualisation of the Sog protein gradient.
Extracellular inhibitors are commonly used in development to modulate the activities of signalling molecules. Direct visualisation in the Drosophila embryo of Sog, a Dpp/Scw inhibitor, has now revealed a graded distribution established by degradation and endocytosis.
Ashe
Hilary L
HL
School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, M13 9PT, Manchester, UK. Hilary.Ashe@man.ac.uk
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D004058:Diffusion; D004330:Drosophila / Q000196:embryology* / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism; D004705:Endocytosis; D019476:Insect Proteins / Q000378:metabolism*; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
D019485:Bone Morphogenetic Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; C091428:sog protein, Drosophila