Messenger RNA degradation: beginning at the end.
The mechanisms responsible for mRNA decay in mammalian cells, and how specific sequence elements accelerate decay, are unknown. Recent work indicates that 'ARE' instability elements recruit the exosome to promote rapid 3'-to-5' degradation of the mRNA.
van Hoof
Ambro
A
Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA. ambro@u.arizona.edu
Parker
Roy
R
D020413:3' Untranslated Regions / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001482:Base Composition; D011061:Poly A / Q000378:metabolism; D012315:RNA Caps / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics
D020413:3' Untranslated Regions; D012315:RNA Caps; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D011061:Poly A