title: Placental pathology in early onset pre-eclampsia and intra-uterine growth restriction in women with and without thrombophilia.
abstract: OBJECTIVE
  The incidence of placental thrombotic lesions in early onset preeclampsia (PE) and/or intrauterine growth restriction (IUGR) were compared between women with and without thrombophilia or hyperhomocysteinemia.
  
  
  METHODS
  Matched case-control study. 183 women with a history of early onset PE and/or IUGR were tested for thrombophilia and hyperhomocysteinemia. From the 66 women with a thrombophilic factor the placental histological slides were available in 47 women. These were matched for maternal condition (PE and/or IUGR), gestational age at delivery, parity and maternal age, to 47 women with no thrombophilic factor. All slides were revised for lymphohistiocytic villitis, fetal thrombosis and fibrin depositions.
  
  
  RESULTS
  There were no significant differences between the placentas of the matched groups with and without a thrombophilic factor.
  
  
  CONCLUSIONS
  Placental thrombotic and inflammatory lesions associated with early onset PE and/or IUGR do not occur more often in women with compared to women without thrombophilia or hyperhomocysteinemia.
authors.affiliation: Department of Obstetrics, University Medical Center, Utrecht, The Netherlands. J.M.Sikkema@azu.nl
authors.forename: J M
authors.initials: JM
authors.lastname: Sikkema
authors.forename: A
authors.initials: A
authors.lastname: Franx
authors.forename: H W
authors.initials: HW
authors.lastname: Bruinse
authors.forename: N G
authors.initials: NG
authors.lastname: van der Wijk
authors.forename: H W
authors.initials: HW
authors.lastname: de Valk
authors.forename: P G J
authors.initials: PG
authors.lastname: Nikkels
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000150:complications* / Q000473:pathology*; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications; D007249:Inflammation / Q000473:pathology; D010920:Placenta / Q000378:metabolism / Q000473:pathology*; D011225:Pre-Eclampsia / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D011247:Pregnancy; D019851:Thrombophilia / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D013927:Thrombosis / Q000473:pathology
chemical_list: D005337:Fibrin