[Antioxidant therapy in vascular and renal diseases].
BACKGROUND
Reactive oxygen species are known to play an important role in the pathogenesis of several diseases including atherosclerosis.
Epidemiologic studies suggested a protective effect of antioxidative vitamins on atherosclerotic vascular diseases. However, prospective randomized studies failed to detect any beneficial effect of antioxidative vitamins, including tocopherol, on cardiovascular mortality.
On the other hand, antioxidative therapies have been shown to prevent acute decreases of renal function induced by ischemia, contrast media or drugs. It is unknown whether antioxidative therapy also has beneficial effects in patients with chronic renal failure.
Tepel
Martin
M
Medizinische Klinik IV, Klinikum Benjamin Franklin der Freien Universität Berlin.
van der Giet
Markus
M
Zidek
Walter
W
D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000401:mortality / Q000517:prevention & control*; D003287:Contrast Media / Q000009:adverse effects; D018849:Controlled Clinical Trials as Topic; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D007676:Kidney Failure, Chronic / Q000517:prevention & control; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011446:Prospective Studies; D017382:Reactive Oxygen Species; D006435:Renal Dialysis; D012306:Risk; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D024505:Tocopherols / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
D000975:Antioxidants; D003287:Contrast Media; D010919:Placebos; D017382:Reactive Oxygen Species; D014815:Vitamins; D024505:Tocopherols