title: Widespread skin-limited adult Langerhans cell histiocytosis: long-term follow-up with good response to interferon alpha.
abstract: Langerhans cell histiocytosis (LCH) most frequently involves bone, but also involves the skin in 40% of cases; in 10% of patients it is limited to the skin. Cutaneous findings of skin-limited LCH are scaly papules, vesicles, nodules, tumours with erosion, ulceration, or crusting and/or purpura. We report a case of widespread adult-onset LCH confined to skin in which topical carmustine, photochemotherapy, systemic steroids, and 2-chlorodeoxyadenosine were only partially effective. However, longer remission was achieved by the use of subcutaneous interferon-alpha2b.
authors.affiliation: Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, Korea. cse@snu.md
authors.forename: S E
authors.initials: SE
authors.lastname: Chang
authors.forename: G J
authors.initials: GJ
authors.lastname: Koh
authors.forename: J H
authors.initials: JH
authors.lastname: Choi
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
authors.forename: K J
authors.initials: KJ
authors.lastname: Sung
authors.forename: K C
authors.initials: KC
authors.lastname: Moon
authors.forename: J K
authors.initials: JK
authors.lastname: Koh
mesh_terms: D003879:Dermatologic Agents / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006646:Histiocytosis, Langerhans-Cell / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins