title: Chemical synthesis and calcium release activity of N(1)-ether strand substituted cADPR mimic.
abstract: 8-Chloro cyclic inosine 5'-diphosphate ethoxymethyl ether 3 was synthesized by means of chemical method from protected inosine via phenylthio-type biphosphate substrate. The detection of Ca(2+) release activity shows that 3 is a potent agonist of cADPR and has activity in intact Hela cells.
authors.affiliation: National Research Laboratory of Natural and Biomimetic Drugs, Peking University, 100083, Beijing, PR China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Huang
authors.forename: Yong-Yuan
authors.initials: YY
authors.lastname: Zhao
authors.forename: Lan
authors.initials: L
authors.lastname: Yuan
authors.forename: Ji-Mei
authors.initials: JM
authors.lastname: Min
authors.forename: Li-He
authors.initials: LH
authors.lastname: Zhang
mesh_terms: D002118:Calcium / Q000378:metabolism*; D036563:Cyclic ADP-Ribose / Q000819:agonists* / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D018716:Molecular Mimicry; D013329:Structure-Activity Relationship
chemical_list: D004987:Ethers; D036563:Cyclic ADP-Ribose; D002118:Calcium