Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors.
Protein kinase A (PKA) and neuronal nitric oxide synthase (nNOS) are important signaling molecules. It is well known that PKA can specifically phosphorylate nNOS. But the underlying molecular mechanism is still obscure. Our data indicate that the protein inhibitor of nNOS (PIN) binds to protein kinase A inhibitors (PKIs), which suggests that PKIs, together with PIN, might mediate the phosphorylation of nNOS by PKA.
Yu
Jianqiang
J
State Key Laboratory of Genetics Engineering, Institute of Genetics, School of Life Science, Fudan University, 220 Handan Road, Shanghai 200433, PR China.
Yu
Long
L
Chen
Zheng
Z
Zheng
Lihua
L
Chen
Xiaosong
X
Wang
Xiang
X
Ren
Daming
D
Zhao
Shouyuan
S
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002478:Cells, Cultured; D002490:Central Nervous System / Q000201:enzymology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D029721:Drosophila Proteins; D004398:Dyneins; D017930:Genes, Reporter / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D026602:Nitrergic Neurons / Q000201:enzymology*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction / Q000235:genetics; D009435:Synaptic Transmission / Q000502:physiology*; D020798:Two-Hybrid System Techniques; D015003:Yeasts / Q000201:enzymology
D002352:Carrier Proteins; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; C015482:protein kinase modulator; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D017868:Cyclic AMP-Dependent Protein Kinases; D004398:Dyneins