Bradykinin for the treatment of cardiovascular disease.
Bradykinin is a vasoactive kinin known to be involved in many biologic processes. Levels of bradykinin have been shown to be elevated in a number of cardiac diseases. It is thought that these elevated levels play a protective role in cardiovascular diseases. Preliminary studies have demonstrated that bradykinin may have beneficial effects on a wide spectrum of cardiovascular disorders. Though much study is still required, bradykinin augmentation represents an exciting new target for the treatment of cardiovascular disease.
Palkhiwala
S A
SA
Beth Israel Medical Center, New York, New York, USA.
Frishman
W H
WH
Warshafsky
S
S
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001920:Bradykinin / Q000502:physiology / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D018002:Receptors, Bradykinin / Q000378:metabolism; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*; D020257:Ventricular Remodeling / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D018002:Receptors, Bradykinin; D014665:Vasodilator Agents; D001920:Bradykinin