Electrospray ionization mass spectrometric studies of phosphorus oxychloride directed synthesis of homo-oligopeptide ester libraries.
With the assistance of phosphorus oxychloride, alpha-amino acids were assembled into homo-peptides, which were analyzed by electrospray ionization mass spectrometry (ESI-MS) and multistage electrospray ionization mass spectrometry (ESI-MS/MS). On quenching with water or various alcohols, the reaction mixtures yielded the corresponding peptides or peptide esters, respectively. This paper reports a simple method to synthesize the homo-oligo-peptide-ester conjugated library by phosphorus oxychloride activation.
Zhou
Ning
N
School of Chemistry and Engineering, Xiamen University, 361005, P.R. China.
Lu
Kui
K
Liu
Yan
Y
Chen
Yi
Y
Tang
Guo
G
Cao
Shu-Xia
SX
Qu
Ling-Bo
LB
Zhao
Yu-Fen
YF
D000596:Amino Acids / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D007202:Indicators and Reagents; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D019151:Peptide Library; D017553:Phosphorus Compounds / Q000737:chemistry*; D012044:Regression Analysis; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D000596:Amino Acids; D007202:Indicators and Reagents; D009842:Oligopeptides; D019151:Peptide Library; D017553:Phosphorus Compounds; C013196:phosphoryl chloride