Goodpasture syndrome during the course of a Schönlein-Henoch purpura.
Two months after surgical resection of a bronchogenic carcinoma, a 69-year-old patient presented with Schönlein-Henoch purpura with kidney involvement followed by pulmonary hemorrhage. The presence of an IgA linear pattern on the kidney biopsy specimen and circulating anti-glomerular basement membrane (GBM) IgA antibodies led to the diagnosis of Goodpasture syndrome, which implies the possibility that the well-known pulmonary involvement during the course of Schönlein-Henoch purpura could be caused by Goodpasture syndrome in certain cases. In cases of glomerulonephropathy with lung involvement, clinicians should not limit their investigations to anti-GBM IgG.
Carreras
Luis
L
Department of Nephrology, Hospital Princeps d'Espanya, CUSB, Barcelona, Spain. 4661lcb@comb.es
Poveda
Rafael
R
Bas
Jordi
J
Mestre
Mariona
M
Rama
Inés
I
Carrera
Marta
M
D000368:Aged; D019867:Anti-Glomerular Basement Membrane Disease / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D004334:Drug Administration Schedule; D017809:Fatal Outcome; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D007070:Immunoglobulin A / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D007262:Infusions, Intravenous; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use
D007070:Immunoglobulin A; D016756:Immunoglobulins, Intravenous; D011241:Prednisone