title: Protein kinase D: an intracellular traffic regulator on the move.
abstract: Recent research has identified protein kinase D (PKD, also called PKCmu) as a serine/threonine kinase with potentially important roles in growth factor signaling as well as in stress-induced signaling. Moreover, PKD has emerged as an important regulator of plasma membrane enzymes and receptors, in some cases mediating cross-talk between different signaling systems. The recent discovery of two additional kinases belonging to the PKD family and the plethora of proteins that interact with PKD point to a multifaceted regulation and a multifunctional role for these enzymes, with functions in processes as diverse as cell proliferation, apoptosis, immune cell regulation, tumor cell invasion and regulation of Golgi vesicle fission.
authors.affiliation: Division of Biochemistry, Faculty of Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000, Leuven, Belgium. Johan.Vanlint@med.kuleuven.ac.be
authors.forename: Johan
authors.initials: J
authors.lastname: Van Lint
authors.forename: An
authors.initials: A
authors.lastname: Rykx
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Maeda
authors.forename: Tibor
authors.initials: T
authors.lastname: Vantus
authors.forename: Sabine
authors.initials: S
authors.lastname: Sturany
authors.forename: Vivek
authors.initials: V
authors.lastname: Malhotra
authors.forename: Jackie R
authors.initials: JR
authors.lastname: Vandenheede
authors.forename: Thomas
authors.initials: T
authors.lastname: Seufferlein
mesh_terms: D000818:Animals; D006801:Humans; D011493:Protein Kinase C / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D020239:Receptor Cross-Talk; D015290:Second Messenger Systems / Q000502:physiology*
chemical_list: C089212:protein kinase D; D017346:Protein Serine-Threonine Kinases; D011493:Protein Kinase C