Spasmolytic activity of some plants used by the Otomi Indians of Quéretaro (México) for the treatment of gastrointestinal disorders.
The present study was performed to investigate the effect of chloroform-methanol (1:1) extracts derived from Baccharis heterophylla H. B. K (Asteraceae), Desmodium grahami Gray (Leguminosae), Dyssodia pinnata var. pinnata Rob. (Asteraceae), Gentiana spathacea H. B. K. (Gentianaceae), Loeselia mexicana Brand. (Polemoniaceae), Selaginella pallescens Spring. (Selaginellaceae) and Zornia diphylla Pers. (Fabaceae) on the spontaneous contractions of isolated rat ileum. The concentration-response curves and IC50 values were obtained and the respective relaxant potencies were compared with that of the CHCl3-MeOH (1:1) extract of Datura lanosa. The data showed that all the extracts produce a concentration-dependent inhibition of spontaneous ileum contractions. In addition, the antimicrobial activity of the extracts against pathogenic enterobacteria was tested. The pharmacological actions shown by the extracts of the selected species tend to support ethnomedical use of the plants for the treatment of gastrointestinal disorders.
Rojas
A
A
Facultad de Quimica, Universitiad Autónoma de Querétaro, Centro Universitario, México.
Bah
M
M
Rojas
J I
JI
Serrano
V
V
Pacheco
S
S
D000818:Animals; D008297:Male; D051381:Rats; D004305:Dose-Response Relationship, Drug; D019448:Ethnobotany; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000503:physiopathology; D007082:Ileum / Q000187:drug effects / Q000503:physiopathology; D007198:Indians, North American; D019684:Magnoliopsida / Q000737:chemistry; D008519:Medicine, Traditional; D008800:Mexico / Q000208:ethnology; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000503:physiopathology; D010276:Parasympatholytics / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D017207:Rats, Sprague-Dawley; D006801:Humans
D010276:Parasympatholytics; D010936:Plant Extracts