Buruli ulcer.
Buruli ulcer (Mycobacterium ulcerans) is an emerging disease. The mode of transmission is still unknown. Mycobacterium ulcerans has been detected (by polymerase chain reaction) in water and water insects. Extensive surgery is still the main treatment. Recognition and excision - of the early nodular stage - is effective. The toxin, a polyketide, causes immunosuppression with potent inhibition of monocytes, T cells and nuclear factor kappa-B activation.
Evans
Mark R.W.
MR
Division of Infectious Diseases, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.
Thangaraj
Harry S.
HS
Wansbrough-Jones
Mark H.
MH