title: Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters.
abstract: Iodinated 3beta-aryltropanes functionalized appropriately at the 2beta-, 8- and aryl positions display selective binding to either the dopamine or serotonin transporters.
authors.affiliation: Department of Chemistry, State University of New York at Buffalo, 14260-3000, USA. hdavies@pop.ascu.buffalo.edu
authors.forename: Huw M L
authors.initials: HM
authors.lastname: Davies
authors.forename: Pingda
authors.initials: P
authors.lastname: Ren
authors.forename: Norman X
authors.initials: NX
authors.lastname: Kong
authors.forename: Tammy
authors.initials: T
authors.lastname: Sexton
authors.forename: Steven R
authors.initials: SR
authors.lastname: Childers
mesh_terms: D001665:Binding Sites; D001667:Binding, Competitive; D002352:Carrier Proteins / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins; D006847:Hydrocarbons, Iodinated / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D012701:Serotonin / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins; D013329:Structure-Activity Relationship; D014326:Tropanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D006847:Hydrocarbons, Iodinated; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins; D014326:Tropanes; D012701:Serotonin; D004298:Dopamine