title: Hostility, race, and glucose metabolism in nondiabetic individuals.
abstract: OBJECTIVE
  The present study was designed to determine whether hostility is differentially related to measures of glucose metabolism in African-Americans and Caucasians.
  
  
  METHODS
  The relationship of hostility, as measured by a subset of the Cook-Medley hostility scale (CMHOST) inventory items, to various parameters of glucose metabolism were examined in a young, healthy sample of male and female African-American and Caucasian volunteers. Fasting blood samples were collected during an inpatient admission, at which time the CMHOST was also administered.
  
  
  RESULTS
  In the entire sample, the CMHOST was found to be significantly correlated with fasting glucose and insulin sensitivity, as measured by the homeostatic model assessment (HOMA). However, the relationship of hostility to these parameters of glucose metabolism was different in African-American and Caucasian subjects. Hostility was significantly related to fasting glucose in African-Americans and to insulin sensitivity and fasting insulin in Caucasian subjects. The relationship of hostility to insulin sensitivity and fasting insulin was partially dependent on BMI in Caucasians, but the relationship of hostility to fasting glucose was unrelated to BMI in African-Americans.
  
  
  CONCLUSIONS
  Our data suggest that the relationship of hostility to measures of glucose metabolism is mediated differently in these two ethnic groups. Therefore, hostility seems to be part of a constellation of risk-related behaviors related to BMI in Caucasians but independently related to fasting glucose in African-Americans.
authors.affiliation: Department of Psychiatry, Duke University School of Medicine, Durham, North Carolina 27710, USA. richard.surwit@duke.edu
authors.forename: Richard S
authors.initials: RS
authors.lastname: Surwit
authors.forename: Redford B
authors.initials: RB
authors.lastname: Williams
authors.forename: Ilene C
authors.initials: IC
authors.lastname: Siegler
authors.forename: James D
authors.initials: JD
authors.lastname: Lane
authors.forename: Michael
authors.initials: M
authors.lastname: Helms
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Applegate
authors.forename: Nancy
authors.initials: N
authors.lastname: Zucker
authors.forename: Mark N
authors.initials: MN
authors.lastname: Feinglos
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: McCaskill
authors.forename: John C
authors.initials: JC
authors.lastname: Barefoot
mesh_terms: D000328:Adult; D001741:Black or African American / Q000523:psychology; D044383:Black People; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000208:ethnology* / Q000523:psychology; D005260:Female; D015438:Health Behavior; D006791:Hostility; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D010551:Personality; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D044465:White People / Q000523:psychology
chemical_list: D001786:Blood Glucose; D007328:Insulin