title: Messenger RNA degradation: beginning at the end.
abstract: The mechanisms responsible for mRNA decay in mammalian cells, and how specific sequence elements accelerate decay, are unknown. Recent work indicates that 'ARE' instability elements recruit the exosome to promote rapid 3'-to-5' degradation of the mRNA.
authors.affiliation: Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA. ambro@u.arizona.edu
authors.forename: Ambro
authors.initials: A
authors.lastname: van Hoof
authors.forename: Roy
authors.initials: R
authors.lastname: Parker
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001482:Base Composition; D011061:Poly A / Q000378:metabolism; D012315:RNA Caps / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics
chemical_list: D020413:3' Untranslated Regions; D012315:RNA Caps; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D011061:Poly A