Airway remodelling in the pathogenesis of asthma.
The inflammatory and remodelling processes that underlie asthma result from a highly complex interaction between various cell types. Apart from inflammatory cells, such as eosinophils, activated T cells, mast cells and macrophages, structural tissue cells such as epithelial cells, fibroblasts and smooth muscle cells can also play an important effector role through the release of a variety of mediators, cytokines and chemokines. This results in an acute inflammatory response that is characterized by vascular leakage, mucus hypersecretion, epithelial shedding and widespread airway narrowing. At the same time, through the release of mediators, cytokines, chemokines and growth factors, epithelial and mesenchymal cells cause persistence of the inflammatory infiltrate and induce structural changes in the airway wall, such as increased thickness of the basement membrane, increased collagen deposition, changes in bronchial microcirculation, and smooth muscle hypertrophy and hyperplasia. The end result of airway inflammation and remodelling is an increased thickness of the airway wall, leading to a reduced baseline airway calibre and exaggerated airway narrowing.
Chiappara
G
G
Istituto di Fisiopatologia Respiratoria, Palermo, Italy.
Gagliardo
R
R
Siena
A
A
Bonsignore
M R
MR
Bousquet
J
J
Bonsignore
G
G
Vignola
A M
AM
D000818:Animals; D001249:Asthma / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D001485:Basement Membrane / Q000473:pathology; D001980:Bronchi / Q000473:pathology / Q000502:physiology*; D016535:Bronchial Hyperreactivity / Q000209:etiology; D005347:Fibroblasts / Q000502:physiology; D005541:Forced Expiratory Volume; D006801:Humans; D008407:Mast Cells / Q000502:physiology; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D009130:Muscle, Smooth / Q000473:pathology; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000502:physiology
D019715:Tissue Inhibitor of Metalloproteinase-1; D020780:Matrix Metalloproteinase 9