title: Indonesian medicinal plants. XXIV. Stereochemical structure of perseitol x K+ complex isolated from the leaves of Scurrula fusca (Loranthaceae).
abstract: A complex of perseitol (D-glycero-D-galacto-heptitol) and K+ ions in a molar ratio of 20:1 was isolated from the leaves of Scurrula fusca (Loranthaceae), which has been traditionally used for the treatment of cancer in Sulawesi Island, Indonesia. The stereochemical structure of the complex in H2O solution has been elucidated by use of several kinds of NMR techniques. Furthermore, it has been found that the complex exhibits a potent inhibitory effect on [3H]-leucine incorporation for protein synthesis in Ehrlich ascites tumor cells in mice.
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishizu
authors.forename: Hendig
authors.initials: H
authors.lastname: Winarno
authors.forename: Etsuji
authors.initials: E
authors.lastname: Tsujino
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Morita
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Shibuya
mesh_terms: D000107:Acetylation; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D006539:Heptoses / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007214:Indonesia; D028183:Loranthaceae / Q000737:chemistry*; D051379:Mice; D008968:Molecular Conformation; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011188:Potassium / Q000737:chemistry* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006539:Heptoses; D009363:Neoplasm Proteins; C025642:perseitol; D011188:Potassium