Novel diamide-based inhibitors of IMPDH.
A series of novel amide-based small molecule inhibitors of inosine monophosphate dehydrogenase is described. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are presented.
Gu
Henry H
HH
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. henry.gu@bms.com
Iwanowicz
Edwin J
EJ
Guo
Junqing
J
Watterson
Scott H
SH
Shen
Zhongqi
Z
Pitts
William J
WJ
Dhar
T G Murali
TG
Fleener
Catherine A
CA
Rouleau
Katherine
K
Sherbina
N Z
NZ
Witmer
Mark
M
Tredup
Jeffrey
J
Hollenbaugh
Diane
D
D002384:Catalysis; D003958:Diamide / Q000737:chemistry* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D003958:Diamide; D007168:IMP Dehydrogenase