Nuclear factor kappa B signaling in catabolic disorders.
The nuclear factor kappa B family of inducible transcription factors regulates the expression of many genes. Nuclear factor kappa B has been implicated in autoimmune and inflammatory diseases, infection, cell survival, and cell transformation with subsequent promotion of cancer. In this review, we summarize features of nuclear factor kappa B regulation in several catabolic disorders, and describe its role in normal cellular function as well as provide an important link to the role of scaffold proteins, cellular receptors, and other cell signaling pathway kinases that converge on the nuclear factor kappa B signaling cascade. Subsequently, we focus on the role of nuclear factor kappa B in cell survival and oxidative stress. Finally, potential therapeutic strategies are discussed that may modify nuclear factor kappa B activity including endogenous antioxidant systems and the Fas/FasL system. However, challenges still remain in developing new therapeutic strategies that not only include identifying novel agents, but also by improving clinical endpoint definitions and by defining biological efficacy.
Holmes-McNary
Minnie
M
College of Human Ecology and Medicine, Department of Human Nutrition, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210-1295, USA. holmes-mcnary.1@osu.edu
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001327:Autoimmune Diseases / Q000503:physiopathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006111:Graves Disease / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D016328:NF-kappa B / Q000378:metabolism* / Q000502:physiology; D009369:Neoplasms / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013967:Thyroiditis, Autoimmune / Q000503:physiopathology
D000975:Antioxidants; D016328:NF-kappa B