title: Hepatocyte growth factor (HGF) as a rapid diagnostic marker and its potential in the prevention of acute renal rejection.
abstract: Several investigators have reported that hepatocyte growth factor (HGF) may be related to the protection or reconstruction of the kidney during acute renal rejection. To address this question, we examined the relationship between HGF and acute rejection in the following two studies with rat renal transplantation models. In study 1, the relationship between serum HGF levels and acute renal rejection in iso-, allo- and allograft with cyclosporine (CsA)-treated models was examined. In study 2, the focus was whether or not the injection of recombinant HGF can prevent acute renal rejection. Our results demonstrated that HGF levels were rapidly increased during acute rejection and that recombinant HGF effectively protected the kidney from acute rejection. These results suggest that HGF may be induced as a counter-response to the renal injury and that it can be used as a reliable indicator for the diagnosis of acute rejection. We suggest that recombinant HGF suppresses the onset of the pathological changes of acute rejection.
authors.affiliation: Department of Urology, Osaka City University Hospital, 1-4-3 Asahi-machi, Abenoku, Osaka 545-8585, Japan. hasetaro@msic.med.osaka-cu.ac.jp
authors.forename: Rikio
authors.initials: R
authors.lastname: Yoshimura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Sinji
authors.initials: S
authors.lastname: Kasai
authors.forename: Seiji
authors.initials: S
authors.lastname: Wada
authors.forename: Akira
authors.initials: A
authors.lastname: Ohyama
authors.forename: Taro
authors.initials: T
authors.lastname: Hase
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakatani
authors.forename: Jamel
authors.initials: J
authors.lastname: Chargui
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Touraine
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000208:Acute Disease; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D006084:Graft Rejection / Q000473:pathology / Q000517:prevention & control*; D017228:Hepatocyte Growth Factor / Q000032:analysis* / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D017208:Rats, Wistar; D014184:Transplantation, Homologous / Q000276:immunology; D014185:Transplantation, Isogeneic / Q000276:immunology
chemical_list: D015415:Biomarkers; D007166:Immunosuppressive Agents; D017228:Hepatocyte Growth Factor