title: Application of ruthenium-induced macrocyclization for the construction of macrocyclic depsipeptides.
abstract: The synthesis of a biaryl ether containing macrocyclic depsipeptide 1 was achieved in 6% overall yield. The desired macrocycle was constructed by cyclization of a phenol into eta(6)-ruthenium complex. The ruthenium metal was subsequently photolytically deprotected to obtain the macrocycle 1.
authors.affiliation: Schering Plough Research Institute, K-15, 3545, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. Srikanth.Venkatraman@spcorp.com
authors.forename: Srikanth
authors.initials: S
authors.lastname: Venkatraman
authors.forename: F George
authors.initials: FG
authors.lastname: Njoroge
authors.forename: Viyyoor
authors.initials: V
authors.lastname: Girijavallabhan
authors.forename: Andrew T
authors.initials: AT
authors.lastname: McPhail
mesh_terms: D002384:Catalysis; D002855:Chromatography, Thin Layer; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D018360:Crystallography, X-Ray; D003500:Cyclization; D004952:Esters / Q000138:chemical synthesis; D004987:Ethers / Q000138:chemical synthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D004952:Esters; D004987:Ethers; D010456:Peptides, Cyclic; D012428:Ruthenium