Is diminished pubocervical fascia collagen content a risk factor for failure of surgical management of genuine stress urinary incontinence in women?
OBJECTIVE
The assessment of relationship between pubocervical collagen content and clinical results of surgical treatment of genuine stress urinary incontinence (GSUI) in women.


METHODS
Twenty-four women treated for genuine stress urinary incontinence were included into the study. All women underwent the same surgical procedure. The samples of pubocervical fascia were taken at the time of surgery. The contents of acid soluble, pepsin soluble, insoluble fraction of collagen, total collagen and collagen crosslinks were measured. The study of pubocervical fascia collagen metabolism included also estimation of collagenase activity. At follow-up done 5 years following surgery, 20 patients reported symptoms of GSUI (study group). Four women were still without symptoms of urine leakage (control group).


RESULTS
The biochemical parameters of pubocervical fascia did not show, statistically significant differences between compared groups.


CONCLUSIONS
The pubocervical fascia collagen metabolism does not have impact on the results of anti-incontinence surgery.
Skorupski
Pawel
P
Department of Gynecological Surgery, University School of Medicine, 20-954 Lublin, Jaczewskiego 8, Poland skorup@eskulap.am.lublin.pl
Rechberger
Tomasz
T
Postawski
Krzysztof
K
Woessner
J Frederick
JF
Jakowicki
Jerzy A
JA
D002584:Cervix Uteri; D003094:Collagen / Q000032:analysis*; D003238:Connective Tissue / Q000737:chemistry*; D005205:Fascia / Q000737:chemistry*; D005260:Female; D006801:Humans; D011630:Pubic Bone; D012307:Risk Factors; D017211:Treatment Failure; D001743:Urinary Bladder / Q000601:surgery; D014550:Urinary Incontinence, Stress / Q000601:surgery*
D003094:Collagen