title: In vitro activity of linezolid against Clostridium difficile.
abstract: We examined the in vitro activity of linezolid against Clostridium difficile, including isolates with reduced susceptibility to metronidazole or vancomycin. The MIC at which 50% of the isolates were inhibited (MIC50) and MIC90 were 0.5 and 2 microg/ml, respectively (range, 0.03 to 4 microg/ml). MICs were always <or= 4 microg/ml, and thus, all isolates were considered susceptible.
authors.affiliation: Microbiology and Infectious Diseases Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Peláez
authors.forename: R
authors.initials: R
authors.lastname: Alonso
authors.forename: C
authors.initials: C
authors.lastname: Pérez
authors.forename: L
authors.initials: L
authors.lastname: Alcalá
authors.forename: O
authors.initials: O
authors.lastname: Cuevas
authors.forename: E
authors.initials: E
authors.lastname: Bouza
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects*; D003967:Diarrhea / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology; D006801:Humans; D000069349:Linezolid; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000592:standards; D023303:Oxazolidinones / Q000494:pharmacology*; D020713:Vancomycin Resistance
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D008795:Metronidazole; D000069349:Linezolid