title: Probing the overlap of chorismate mutase and prephenate dehydrogenase sites in the escherichia coli T-protein: a dehydrogenase-selective inhibitor.
abstract: An inhibitor of prephenate dehydrogenase has been identified that has no effect on the chorismate mutase activity in the Escherichia coli T-protein, thus supporting the idea of two separate active sites.
authors.affiliation: Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Vincent
authors.forename: Shuqing
authors.initials: S
authors.lastname: Chen
authors.forename: David B
authors.initials: DB
authors.lastname: Wilson
authors.forename: Bruce
authors.initials: B
authors.lastname: Ganem
mesh_terms: D001665:Binding Sites; D002826:Chorismate Mutase / Q000187:drug effects / Q000378:metabolism*; D004791:Enzyme Inhibitors; D004926:Escherichia coli / Q000737:chemistry; D007700:Kinetics; D011303:Prephenate Dehydrogenase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D011303:Prephenate Dehydrogenase; D002826:Chorismate Mutase