[Role of interferon alpha in the management of severe acute pancreatitis].
OBJECTIVE
To investigate the efficacy of IFN-alpha on severe acute pancreatitis (SAP) of IFN-alpha.


METHODS
A SAP model was developed in adult male rats by retrograde injection of 5% sodium taurocholate in the pancreatic duct. Serum amylase was measured by the blue-starch method and serum cytokines were determined by ELISA.


RESULTS
Compared with to the control group, less pancreatic injury and lower amylase level were observed treat in the rats with IFN-alpha. In contrast, the concentration of IL-10 was higher.


CONCLUSIONS
IFN-alpha has significant curative effect on SAP.
Tang
Yaoqing
Y
Department of Surgery, Ruijin Hospital of Shanghai Second Medical University, Shanghai 200025, China.
Qi
Dachuan
D
Wu
Jun
J
Mao
Enqiang
E
Ji
Jun
J
Han
Tianquan
T
Zhang
Shendao
S
D000818:Animals; D004195:Disease Models, Animal; D007155:Immunologic Factors / Q000627:therapeutic use*; D016898:Interferon-alpha / Q000627:therapeutic use*; D016753:Interleukin-10 / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008297:Male; D019283:Pancreatitis, Acute Necrotizing / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D007155:Immunologic Factors; D016898:Interferon-alpha; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10