Age-specific incidence rates for cytogenetically-defined subtypes of acute myeloid leukaemia.
It is generally considered that most cancers arise following the accumulation of several genetic events and that as a consequence its incidence increases with age. We report a cytogenetic subgroup of acute myeloid leukaemia whose incidence is independent of age. This observation indicates that acute myeloid leukaemia can develop via multiple pathways, and underlines the importance of cytogenetics in understanding this disease.
Moorman
A V
AV
Leukaemia Research Fund Centre for Clinical Epidemiology, University of Leeds University, Leeds, UK. avm@soton.ac.uk
Roman
E
E
Cartwright
R A
RA
Morgan
G J
GJ
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D015994:Incidence; D007951:Leukemia, Myeloid / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged