Structural identification of new curcumin dimers and their contribution to the antioxidant mechanism of curcumin.
As a part of the research project on the elucidation of the chain-breaking antioxidant mechanism of natural phenolics against the oxidation of food components, curcumin, a main turmeric pigment, was investigated. A relatively high concentration of curcumin gave three dimers as radical termination products in addition to the coupling products with curcumin and the lipid hydroperoxide. The structural analysis of these dimers and quantitative analysis of their production rates revealed that radical-radical termination mainly occurred at the 2-position of curcumin. The contribution of the pathway for production of these dimers to the antioxidant mechanism of curcumin was estimated from the concentration-dependent data of the antioxidant activity and formation rates of these termination products. The A-A termination (dimer formation) was estimated to contribute at least about 40% of the entire antioxidant process against ethyl linoleate oxidation.
Masuda
Toshiya
T
Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770-8502, Japan. masuda@ias.tokushima-u.ac.jp
Toi
Yukiko
Y
Bando
Hiromi
H
Maekawa
Tomomi
T
Takeda
Yoshio
Y
Yamaguchi
Hidemasa
H
D000975:Antioxidants / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology*; D019281:Dimerization; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000975:Antioxidants; D005609:Free Radicals; D003474:Curcumin