Variability in the timing of G(1)/S transition.
Cell cycle duration and phase transition times are not fixed, even within homogeneous cell populations growing under optimal environmental conditions. We investigate G(1) phase variability from the molecular point of view and propose a mathematical approach to model the protein interactions regulating the transition from the G(1) phase to the phase of DNA synthesis. The mathematical model has some connections with flow cytometry experimental data.
Chiorino
G
G
Biomathematics Unit, Laboratory of Cancer Pharmacogenomics, Edo Tempia Foundation-SENDO, via Malta 3, 13900 Biella, Italy. giochiorino@hotmail.com
Lupi
M
M
D002455:Cell Division / Q000502:physiology; D003198:Computer Simulation; D019927:Cyclin E / Q000502:physiology; D004247:DNA / Q000096:biosynthesis; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D005434:Flow Cytometry; D016193:G1 Phase / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D016160:Retinoblastoma Protein / Q000502:physiology; D016196:S Phase / Q000502:physiology*
D019927:Cyclin E; D016160:Retinoblastoma Protein; D004247:DNA