Raised plasma G-CSF and IL-6 after exercise may play a role in neutrophil mobilization into the circulation.
We examined the hypothesis that the short, intensive exercise-induced increase in circulating neutrophil counts is affected by the interaction between the endocrine and immune systems. Twelve male winter-sports athletes underwent a maximal exercise test on a treadmill. Blood samples were collected before, immediately after (Post), and 1 h (Post 1 h) and 2 h (Post 2 h) after the exercise. The neutrophil counts increased significantly at Post 1 h (P < 0.05) and remained significantly high even at Post 2 h (P < 0.05), showing a leftward shift. Plasma granulocyte colony-stimulating factor (G-CSF) increased at Post (P < 0.05), and interleukin-6 (IL-6) increased at Post 1 h (P < 0.05). Plasma G-CSF at Post significantly correlated with the numbers of both neutrophils and stab cells at Post 1 h (P < 0.05). Plasma IL-6 at Post 1 h levels also correlated significantly with the number of neutrophils at Post 2 h (P < 0.05). The increase in the levels of plasma G-CSF and IL-6 after intensive exercise may play a role in the mobilization of neutrophils into the circulatory system.
Yamada
Mutsuo
M
Department of Hygiene, Hirosaki University School of Medicine, Aomori 036-8562, Japan.
Suzuki
Katsuhiko
K
Kudo
Satoru
S
Totsuka
Manabu
M
Nakaji
Shigeyuki
S
Sugawara
Kazuo
K
D000293:Adolescent; D000328:Adult; D005080:Exercise Test; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*; D012016:Reference Values; D013177:Sports
D015850:Interleukin-6; D019382:Human Growth Hormone; D016179:Granulocyte Colony-Stimulating Factor; D006854:Hydrocortisone