[Atomic spectrometry methods for the determination of trace metal impurities in pharmaceutical substances].
Direct GFAAS method was developed for determination of traces of platinum metals (Pd, Rh) in pharmaceutical substances. The multielement TXRF method with or without preconcentration was applied as element specific screening procedure for inorganic impurities. It was found that the developed FI-GFAAS method could be used for determination of trace metal impurities (Pb, Ni, Co, Cd, Cr(III)) in pharmaceutical substances in ng/g levels. The two chromium forms can be separated and quantified preconcentrating on IDAEC and anion exchanger (DE cellulose). FI-GFAAS method was worked out using chelating cellulose (IDAEC, DEN-cellulose, and recently synthesised oxime-, and sulphoxine-celluloses) microcolumns for preconcentration of palladium. The preconcentration was optimised by species distribution curves.
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ELTE Szervetlen és Analitikai Kémiai Tanszék, Budapest.
D002852:Chromatography, Ion Exchange / Q000379:methods; D002857:Chromium / Q000032:analysis; D004340:Drug Contamination; D008670:Metals / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010984:Platinum / Q000032:analysis; D012238:Rhodium / Q000032:analysis; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods
D008670:Metals; D004364:Pharmaceutical Preparations; D002857:Chromium; D010984:Platinum; D012238:Rhodium