[Interaction of meso-tetra(N-hydroxyethylpyridyl)porphyrins with DNA. Effect of position of peripheral groups].
The interaction of meso-tetra(4-N-oxyethylpyridyl)porphyrin and its 3-N-substituted analogue with DNA was studied by UV spectrophotometry and circular dichroism methods. It was shown that the position of the side group on the pyridyl ring substantially affects the mechanism of interaction with DNA. 4-N-oxyethylpyridyl porphyrins more preferably intercalate into the DNA structure but worse realize the external binding than 3N-porphyrins.
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Yerevan State University, ul. Manukyana 1, Yerevan, 375025 Armenia.
D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D011166:Porphyrins / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D011166:Porphyrins; D011725:Pyridines; D004247:DNA