title: Hyponatraemia and hyperglycaemia during laproscopic surgery.
abstract: The aim of this masterclass is to develop a rational plan of therapy to deal with a severe degree of hyponatraemia (90 mmol/l) and hyperglycaemia (100 mmol/l) that occurred 100 min after the start of laproscopic surgery in a young woman. The lavage fluid used in this procedure was 10% dextrose.H(2)O in water (505 mmol glucose/l). To focus attention on specific issues, three questions are posed to the reader, as they were to a panel of 59 modern-day experts. Two imaginary consultants from the past were asked the same (and additional) questions. Their responses were restricted to knowledge available before the molecular era, to show the power of integrative physiology at the bedside. An analysis of intracellular events was helpful in answering the first question: 'Is an infusion of hypertonic saline required to treat her acute hyponatremia?' Similarly, a quantitative analysis of changes in the composition of the extracellular fluid compartment was helpful in answering the second question: 'Is an infusion of isotonic saline required to treat her hypotension?' A metabolic analysis was used to answer the third question, 'Should insulin be administered?'
authors.affiliation: Nephrology Unit, Department of Internal Medicine, Stellenbosch University, Cape Town, South Africa.
authors.forename: M R
authors.initials: MR
authors.lastname: Davids
authors.forename: S-H
authors.initials: SH
authors.lastname: Lin
authors.forename: Y
authors.initials: Y
authors.lastname: Edoute
authors.forename: S
authors.initials: S
authors.lastname: Cheema-Dhadli
authors.forename: M L
authors.initials: ML
authors.lastname: Halperin
mesh_terms: D000328:Adult; D005110:Extracellular Space / Q000502:physiology; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000628:therapy*; D007010:Hyponatremia / Q000628:therapy*; D007424:Intracellular Fluid / Q000502:physiology; D007431:Intraoperative Complications / Q000628:therapy*; D010535:Laparoscopy; D007889:Leiomyoma / Q000601:surgery; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000009:adverse effects*; D014594:Uterine Neoplasms / Q000601:surgery
chemical_list: D012462:Saline Solution, Hypertonic