Synthesis of trifluoromethyl ketones using polymer-supported reagents.
A two step synthesis of trifluoromethyl ketones from aldehydes is reported. A combination of polymer-supported reagents and sequestering agents were employed to effect the transformation without the need for chromatographic purification.
Baxendale
I R
IR
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Ley
S V
SV
Lumeras
W
W
Nesi
M
M
D000447:Aldehydes / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry; D007202:Indicators and Reagents; D007475:Ion Exchange Resins; D007659:Ketones / Q000737:chemistry; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry*
D000447:Aldehydes; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D007475:Ion Exchange Resins; D007659:Ketones; D011108:Polymers