The small GTPase Rap1 is an immediate downstream target for Hoxb4 transcriptional regulation.
The Hox genes are a family of homeodomain-containing transcription factors which determine anteroposterior identity early on in development. Although a lot is now known about their regulation and function, very little is known of their effector (downstream target) genes. Here we show that the small GTPase Rap1 is a direct, negatively regulated target of Hoxb4 and is excluded from Hoxb4 expressing cells.
Morsi El-Kadi
Ali S
AS
Department of Anatomy and Developmental Biology, St. George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.
in der Reiden
Paul
P
Durston
Antony
A
Morgan
Richard
R
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D017930:Genes, Reporter; D005938:Glucocorticoids / Q000494:pharmacology; D018398:Homeodomain Proteins / Q000378:metabolism / Q000502:physiology*; D017403:In Situ Hybridization; D008156:Luciferases / Q000378:metabolism; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic; D014981:Xenopus; D020827:rap1 GTP-Binding Proteins / Q000378:metabolism* / Q000502:physiology*
D005938:Glucocorticoids; D018398:Homeodomain Proteins; D011500:Protein Synthesis Inhibitors; D014157:Transcription Factors; D003907:Dexamethasone; D004247:DNA; D003513:Cycloheximide; D008156:Luciferases; D020827:rap1 GTP-Binding Proteins