Regioselective synthesis of 3-alkylindoles mediated by zinc triflate.
Zinc triflate was found to be an effective reagent for the C3-alkylation of indoles by alkyl halides in the presence of Hünig's base and tetrabutylammonium iodide. This new method for indole alkylation proceeds by a S(N)1-like pathway, and is general for allylic, benzylic, and tertiary halides.
Zhu
Xiuwen
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Department of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom.
Ganesan
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