title: Facile Pd-catalyzed cross-coupling of 2'-deoxyguanosine O6-arylsulfonates with arylboronic acids.
abstract: [reaction: see text]. The O6-(2-mesitylenesulfonyl) derivative of 2'-deoxyguanosine undergoes a facile palladium-mediated C-C cross-coupling with arylboronic acids. Demonstrating the general applicability of this method, the synthesis of a previously undescribed class of 2-amino-6-arylpurine 2'-deoxynucleosides has been accomplished. The study also describes an evaluation of the O6-(2,4,6-triisopropylphenylsulfonyl) and the O6-(4-toluenesulfonyl) derivatives for the cross-coupling.
authors.affiliation: Department of Chemistry, City College of CUNY, 138th Street at Convent Avenue, New York, New York 10031-9198, USA. lakshman@sci.ccny.cuny.edu
authors.forename: Mahesh K
authors.initials: MK
authors.lastname: Lakshman
authors.forename: Paul F
authors.initials: PF
authors.lastname: Thomson
authors.forename: Mark A
authors.initials: MA
authors.lastname: Nuqui
authors.forename: John H
authors.initials: JH
authors.lastname: Hilmer
authors.forename: Nonka
authors.initials: N
authors.lastname: Sevova
authors.forename: Bill
authors.initials: B
authors.lastname: Boggess
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D010165:Palladium; D003849:Deoxyguanosine