[A case of fluvoxamine overdose].
Selective serotonin reuptake inhibitors (SSRI) are newly developed-antidepressants authorized in 1999 in Japan. We experienced a case of drug poisoning including fluvoxamine, one of SSRI. A comatose nineteen-year-old girl was transported to our ER in the morning on July 25, 2000. There remained many empty packages of fluvoxamine and several sorts of tranquilizers in the room. Her consciousness became alert over the next morning. HPLC analysis revealed fluvoxamine, chlorpromazine, promethazine, biperiden, phenobarbital, and zopiclone in her blood and that serum concentrations of the first three were above the therapeutic ranges. The peak values of fluvoxamine, chlorpromazine, and promethazine were 1,343 ng/ml (6.7 times of the upper limit), 861 ng/ml (2 times), and 529 ng/ml (1.3 times), respectively. Fluvoxamine must be a main cause of her toxic symptoms although other CNS-depressing drugs might work jointly.
Oka
Hiroyasu
H
Department of Emergency Medicine & Trauma Surgery, Ehime University Hospital.
Shirakawa
Yoichi
Y
Koyama
Kazuhiro
K
Maekawa
Soichi
S
Hirota
Masami
M
Nishizaki
Osamu
O
Fukumoto
Shinya
S
Ochi
Genro
G
D000328:Adult; D000928:Antidepressive Agents / Q000097:blood / Q000506:poisoning*; D002851:Chromatography, High Pressure Liquid; D062787:Drug Overdose; D005260:Female; D016666:Fluvoxamine / Q000097:blood / Q000506:poisoning*; D006801:Humans; D017367:Selective Serotonin Reuptake Inhibitors / Q000097:blood / Q000506:poisoning*; D013997:Time Factors; D014149:Tranquilizing Agents / Q000097:blood / Q000506:poisoning
D000928:Antidepressive Agents; D016666:Fluvoxamine; D017367:Selective Serotonin Reuptake Inhibitors; D014149:Tranquilizing Agents