Oxime derivatives of sordaricin as potent antifungal agents.
Oxime derivatives of the sordarin aglycone have been identified as potent antifungal agents. The in vitro spectrum of activity includes coverage against Candida albicans and Candida glabrata with MICs as low as 0.06 microg/mL. The antifungal activity was established to be exquisitely sensitive to the spatial orientation of the lipophilic side chains.
Serrano-Wu
Michael H
MH
Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. michael.serrano-wu@bms.com
St  Laurent
Denis R
DR
Mazzucco
Charles E
CE
Stickle
Terry M
TM
Barrett
John F
JF
Vyas
Dolatrai M
DM
Balasubramanian
Balu N
BN
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D004224:Diterpenes; D057927:Hydrophobic and Hydrophilic Interactions; D008826:Microbial Sensitivity Tests; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D004224:Diterpenes; D010091:Oximes; C116705:sordaricin