title: Association between IL-4 genotype and IL-4 production in the Japanese population.
abstract: We have identified that there are only two IL-4 gene haplotypes (I and II) in the Japanese population. There are significant differences among three genotypes (I/I, I/II and II/II) in the IL-4 producing proportion of peripheral Th cells using intracellular cytokine detection assay. These results make it likely that IL-4 genotype could influence the type of immune response.
authors.affiliation: Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. hnakashi@intmed1.med.kyushu-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Nakashima
authors.forename: K
authors.initials: K
authors.lastname: Miyake
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Akahoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Otsuka
authors.forename: M
authors.initials: M
authors.lastname: Harada
mesh_terms: D002478:Cells, Cultured; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015847:Interleukin-4 / Q000096:biosynthesis* / Q000235:genetics*; D007564:Japan; D011110:Polymorphism, Genetic; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D015847:Interleukin-4