Ace inhibitors in cardiovascular diseases.
Renin-angiotensin blockade is an important component of management of heart failure in the 21st century. It can be achieved by angiotensin-converting enzyme inhibition (ACEI) and angiotensin receptor blockade (ARB). Neuro-hormonal activation was considered a necessary mechanism for survival of patients with left ventricular dysfunction in 1960s and 1970s. This has been proven to be incorrect, and in fact, there is a large and growing body of evidence showing the cardio-protective effects of RAS and other neuro-hormonal blockade.
Gaddam
Venket
V
Division of Cardiology, Central Arkansas Veteran's Healthcare System, University of Arkansas for Medical Sciences, USA.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D012084:Renin-Angiotensin System / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000145:classification / Q000188:drug therapy*
D000806:Angiotensin-Converting Enzyme Inhibitors