title: [Analysis of risk factors for cervical cancer in Xiangyuan County, Shanxi Province].
abstract: OBJECTIVE
  To investigate the risk factors for cervical cancer in the areas of high incidence, and provide evidence for current intervention of cervical cancer.
  
  
  METHODS
  In the areas of Xiangyuan County, Shanxi Provicne with high incidence of cervical cancer, 1 997 women were interviewed using a questionnaire, including baseline information, menstrual, marital and pregnancy histories, sexual behavior, health habits, contraception, medical history and family history of cancer, etc., after its screening with six kinds of methods. All subjects, including 84 cases with pathological diagnosis of greater than cINI, and 1 784 cases with pathological diagnosis of normal, were tested for high-risk HPV.
  
  
  RESULTS
  The overall rates of HPV infection were 20.8% (415/1 997) in high-risk subjects, 97.7% and 14.2% in the cases and control groups, respectively. Univariate analysis showed that risk factors with statistical significance included high-risk HPV infection, age at first sexual intercourse, history of pregnancy and abortion, the number of sexual partners and family history of cancer. Analysis with non-conditional logistic regression model revealed high-risk HPV infection, multiple sexual partners and family history of cancer associated obviously with occurrence of cervical cancer. In addition, there was significantly positive relationship between HPV infection, which increased with the number of sexual partners, and extramarital sexual activity both in males or females.
  
  
  CONCLUSIONS
  The main risk factor for cervical cancer in this region was high-risk HPV infection, which related to sexual behavior, hygienic habits during menstruation and puerperium. It was particularly important to detect and treat precancerous lesions and to implement behavior modification. In addition, further research on genetic susceptibility was suggested.
authors.affiliation: Department of Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Shoude
authors.initials: S
authors.lastname: Rong
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Lingying
authors.initials: L
authors.lastname: Wu
authors.forename: Xun
authors.initials: X
authors.lastname: Zhang
authors.forename: Guihua
authors.initials: G
authors.lastname: Shen
authors.forename: Yunyuan
authors.initials: Y
authors.lastname: Liu
authors.forename: Fanghui
authors.initials: F
authors.lastname: Zhao
authors.forename: Junfei
authors.initials: J
authors.lastname: Ma
authors.forename: Youlin
authors.initials: Y
authors.lastname: Qiao
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D000704:Analysis of Variance; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D015999:Multivariate Analysis; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000453:epidemiology; D012307:Risk Factors; D012725:Sexual Behavior; D012747:Sexual Partners; D011795:Surveys and Questionnaires; D014412:Tumor Virus Infections / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology