Regiocontrolled synthesis of substituted thiazoles.
The regiocontrolled synthesis of 2,5-disubstituted and 2,4,5-trisubstituted thiazoles from ethyl 2-bromo-5-chloro-4-thiazolecarboxylate 1 using sequential palladium-catalyzed coupling reactions is described. [reaction: see text]
Hodgetts
Kevin J
KJ
Neurogen Corporation, 35 Northeast Industrial Road, Branford, Connecticut 06405, USA. khodgetts@nrgn.com
Kershaw
Mark T
MT
D002384:Catalysis; D007202:Indicators and Reagents; D010165:Palladium / Q000737:chemistry; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry*
D007202:Indicators and Reagents; D013844:Thiazoles; C454808:ethyl 2-bromo-5-chloro-4-thiazolecarboxylate; D010165:Palladium