title: [Results of a cytogenetic study of populations with different radiation risks in the Semipalatinsk region].
abstract: A cytogenetic study was conducted for the first time on human populations neighboring the Semipalatinsk nuclear test site (STS) and exposed to ionizing radiation for a long period of time. In populations with the extreme and maximum radiation risks, high frequencies of radiation-induced chromosomal markers, including acentric fragments (1.99 +/- 0.10 per 100 cells), dicentrics (0.23 +/- 0.01), ring chromosomes (0.38 +/- 0.14), and stable chromosomal aberrations (1.17 +/- 0.02), were found. These frequencies significantly exceeded those in control populations. The spectrum of chromosomal aberrations and the frequencies of the aberrations of different types in persons living in the areas with the highest radionuclide contamination confirmed the mutagenic effect of radiation on chromosomes in the human populations studied.
authors.affiliation: Republican Research Center for Maternal and Children's Health Protection, Almaty, 480020 Kazakhstan.
authors.forename: G S
authors.initials: GS
authors.lastname: Sviatova
authors.forename: G Z
authors.initials: GZ
authors.lastname: Abil'dinova
authors.forename: G M
authors.initials: GM
authors.lastname: Berezina
mesh_terms: D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D004781:Environmental Exposure; D005828:Genetics, Population; D006801:Humans; D007623:Kazakhstan; D009689:Nuclear Warfare; D011831:Radiation Genetics; D011839:Radiation, Ionizing; D012307:Risk Factors