title: [A study on DNA damage of mouse livers induced by methylmercury].
abstract: OBJECTIVE
  To study the DNA damage induced by methylmercury (MeHg) in mouse hepatocytes.
  
  
  METHODS
  The single cell gel electrophoresis (SCGE) was used to study the DNA damage of mouse hepatocytes when treated with different doses in vivo and in vitro.
  
  
  RESULTS
  After treated with high, middle and low doses of MeHg for 12 h in vivo (i.p.), the proportion of DNA damage was increased and the ratio of living cells was decreased; and both effects showed significantly dose-effect relationships. Similar effects were found when different MeHg doses were administered to hepatocytes in vitro for 1 h.
  
  
  CONCLUSIONS
  MeHg induces DNA damage in mouse hepatocytes.
authors.affiliation: Department of Hygienic Chemistry, School of Public Health, Jinlin University, Changchun 130021, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Liu
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Sun
authors.forename: Long
authors.initials: L
authors.lastname: Shi
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004249:DNA Damage; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008767:Methylmercury Compounds / Q000009:adverse effects*; D051379:Mice
chemical_list: D008767:Methylmercury Compounds