title: Spontaneous intracranial hypotension causing reversible frontotemporal dementia.
abstract: Spontaneous intracranial hypotension (SIH) causes postural headache and neurologic symptoms owing to traction and brain compression. A 66-year-old man with chronic headache and progressive personality and behavioral changes typical of frontotemporal dementia was examined. He had MRI findings of SIH with low CSF pressure. His headache, dementia, and imaging abnormalities abated after treatment with prednisone. SIH can cause reversible frontotemporal dementia, and should be considered when dementia and behavioral changes are accompanied by headache.
authors.affiliation: Department of Neurology, University of Michigan, School of Medicine, Ann Arbor, MI 48109-0316, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hong
authors.forename: G V
authors.initials: GV
authors.lastname: Shah
authors.forename: K M
authors.initials: KM
authors.lastname: Adams
authors.forename: R S
authors.initials: RS
authors.lastname: Turner
authors.forename: N L
authors.initials: NL
authors.lastname: Foster
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003704:Dementia / Q000188:drug therapy / Q000209:etiology* / Q000523:psychology*; D005625:Frontal Lobe / Q000502:physiology*; D005684:Gait; D006801:Humans; D019585:Intracranial Hypotension / Q000150:complications* / Q000188:drug therapy / Q000523:psychology*; D008297:Male; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D011241:Prednisone / Q000627:therapeutic use; D013129:Spinal Puncture; D013702:Temporal Lobe / Q000502:physiology*
chemical_list: D000893:Anti-Inflammatory Agents; D011241:Prednisone