title: Imaging of pheochromocytoma in 2 dogs using p-[18F] fluorobenzylguanidine.
abstract: p-[18F]Fluorobenzylguanidine ([18F]PFBG) is a norepinephrine analog that has been developed as a positron emission tomography (PET) imaging radiopharmaceutical. Myocardial sympathetic innervation, neuroendocrine structures, and tumors can be noninvasively imaged with [18F]PFBG. In this study, the uptake characteristics of [18F]PFBG were investigated in 2 dogs with a spontaneous pheochromocytoma. The extent of the pheochromocytoma was well documented in both dogs on the PET study. The standardized uptake values within the pheochromocytomas were greater than 25 by 10 min, and were 37 and 50 by 45 min in each dog. A third dog that was suspected to have an adrenal mass was also studied. In this dog, the [18F]PFBG study was normal. Surgical exploration and adrenal biopsy confirmed the [15F]PFBG imaging findings in both dogs. In each dog, there was rapid blood-pool clearance (within 10 min after intravenous administration of the [18F]PFBG), with high uptake specific within the myocardium and adrenal medulla. The results indicate that [18F]PFBG may be useful for imaging canine pheochromocytomas and aid in differentiating adrenal masses.
authors.affiliation: Department of Anatomy, Physiological Sciences, and Radiology, North Carolina State University, College of Veterinary Medicine, Raleigh 27606, USA.
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Berry
authors.forename: Timothy R
authors.initials: TR
authors.lastname: DeGrado
authors.forename: Felicia
authors.initials: F
authors.lastname: Nutter
authors.forename: Pradeep K
authors.initials: PK
authors.lastname: Garg
authors.forename: Edward B
authors.initials: EB
authors.lastname: Breitschwerdt
authors.forename: Kathy
authors.initials: K
authors.lastname: Spaulding
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Concannon
authors.forename: Michael R
authors.initials: MR
authors.lastname: Zalutsky
authors.forename: R Edward
authors.initials: RE
authors.lastname: Coleman
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000000981:diagnostic imaging*; D004285:Dogs; D005260:Female; D005462:Fluorine Radioisotopes / Q000378:metabolism*; D010673:Pheochromocytoma / Q000000981:diagnostic imaging / Q000662:veterinary*; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes