Bifunctional asymmetric catalysis: a tandem nucleophile/Lewis acid promoted synthesis of beta-lactams.
[reaction: see text]. We describe a superior procedure for the catalytic, asymmetric synthesis of beta-lactams using a bifunctional catalyst system consisting of a chiral nucleophile and an achiral Lewis acid.
France
Stefan
S
Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
Wack
Harald
H
Hafez
Ahmed M
AM
Taggi
Andrew E
AE
Witsil
Daniel R
DR
Lectka
Thomas
T
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002384:Catalysis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry; D013237:Stereoisomerism; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D008670:Metals; D047090:beta-Lactams