title: Frequency of factor V, prothrombin and methylenetetrahydrofolate reductase gene variants in preeclampsia.
abstract: BACKGROUND
  The association between thrombophilic variants (Leiden mutation of the factor V gene, G20210A mutation of the prothrombin gene and C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene) with preeclampsia was investigated in a north-eastern Italian population.
  
  
  METHODS
  Fifty-eight preeclamptic (PE) women and 74 normal pregnancies were evaluated. Genotypes were determined by polymerase chain reaction.
  
  
  RESULTS
  The frequency of heterozygous carriers of the factor V Leiden was similar between PE women (5.2%) compared to the control subjects (4.1%; p 0.76). Also the frequencies of G20210A and C677T mutations were similar between PE and control subjects.
  
  
  CONCLUSIONS
  In this population, we found no difference in the prevalence of genetic risk factors for thrombosis in women with preeclampsia compared with control subjects.
authors.affiliation: Department of Biomedical Science and Technology, University of Udine, Udine, Italy.
authors.forename: Angela V
authors.initials: AV
authors.lastname: D'Elia
authors.forename: Lorenza
authors.initials: L
authors.lastname: Driul
authors.forename: Roberta
authors.initials: R
authors.lastname: Giacomello
authors.forename: Roberta
authors.initials: R
authors.lastname: Colaone
authors.forename: Dora
authors.initials: D
authors.lastname: Fabbro
authors.forename: Cristina
authors.initials: C
authors.lastname: Di Leonardo
authors.forename: Pasquale
authors.initials: P
authors.lastname: Florio
authors.forename: Felice
authors.initials: F
authors.lastname: Petraglia
authors.forename: Diego
authors.initials: D
authors.lastname: Marchesoni
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Damante
mesh_terms: D000328:Adult; D005165:Factor V / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011516:Prothrombin / Q000235:genetics*
chemical_list: D005165:Factor V; D011516:Prothrombin; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)