The cell biology of MHC class I antigen presentation.
MHC class I antigen presentation refers to the co-ordinated activities of many intracellular pathways that promote the cell surface appearance of MHC class I/beta2m heterodimers loaded with a spectrum of self or foreign peptides. These MHC class I peptide complexes form ligands for CD8 positive T cells and NK cells. MHC class I heterodimers are loaded within the endoplasmic reticulum (ER) with peptides derived from intracellular proteins. Alternatively, MHC class I molecules may be loaded with peptides derived from extracellular proteins in a process called MHC class I cross presentation. This pathway is less well defined but can overlap those pathways operating in classical MHC class I presentation and has recently been reviewed elsewhere (1). This review will address the current concepts regarding the intracellular assembly of MHC class I molecules with their peptide cargo within the ER and their subsequent progress to the cell surface.
Williams
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Cancer Sciences Division, University of Southampton School of Medicine, UK.
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Elliott
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D017951:Antigen Presentation; D017920:Antiporters / Q000502:physiology; D001692:Biological Transport; D002135:Calcium-Binding Proteins / Q000502:physiology; D037281:Calnexin; D037282:Calreticulin; D006360:Heat-Shock Proteins / Q000502:physiology; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D007136:Immunoglobulins / Q000502:physiology; D007535:Isomerases / Q000502:physiology; D026901:Membrane Transport Proteins; D018448:Models, Immunological; D018832:Molecular Chaperones / Q000502:physiology; D019704:Protein Disulfide-Isomerases; D017434:Protein Structure, Tertiary; D011956:Receptors, Cell Surface / Q000378:metabolism; D012261:Ribonucleoproteins / Q000502:physiology
D017920:Antiporters; D002135:Calcium-Binding Proteins; D037282:Calreticulin; D006360:Heat-Shock Proteins; D015395:Histocompatibility Antigens Class I; D007136:Immunoglobulins; D026901:Membrane Transport Proteins; D018832:Molecular Chaperones; D011956:Receptors, Cell Surface; D012261:Ribonucleoproteins; C107762:tapasin; D037281:Calnexin; D007535:Isomerases; D019704:Protein Disulfide-Isomerases; C085868:PDIA3 protein, human