[Magnetically-guided anesthetics based on highly dispersed iron powders coated by polyacrylamide].
The effect of external magnetic field (direct and alternating) on the targeted delivery and distribution in body tissues of experimental animals of anesthetics (novocain, lidocaine, and trimecaine) immobilized on highly dispersed ferromagnetics with biocompatible coating was studied by the method of emission spectral analysis. The results are compared with the results obtained earlier on highly dispersed iron powders with dextran coating. The parameters for the powders with dextran coating are considerably lower than those for the magnetic carriers with the polyacrylamide coating.
Kurbatova
G T
GT
Institute of Surface Chemistry, National Academy of Sciences of Ukraine, pr. Nauki 31, Kiev-28, 252028 Ukraine.
Fedorenko
O M
OM
Sokhov
S T
ST
Verkholomova
I A
IA
Shklovskaia
N I
NI
D000180:Acrylic Resins; D000777:Anesthetics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D004337:Drug Carriers; D016503:Drug Delivery Systems; D007501:Iron; D008012:Lidocaine / Q000008:administration & dosage / Q000493:pharmacokinetics; D008280:Magnetics; D008863:Microspheres; D010316:Particle Size; D011208:Powders; D011343:Procaine / Q000008:administration & dosage / Q000493:pharmacokinetics; D011817:Rabbits; D014018:Tissue Distribution; D014288:Trimecaine / Q000008:administration & dosage / Q000493:pharmacokinetics; D000099166:Polyacrylamides
D000180:Acrylic Resins; D000777:Anesthetics; D004337:Drug Carriers; D007501:Iron; D008012:Lidocaine; D011208:Powders; D011343:Procaine; D014288:Trimecaine; D000099166:Polyacrylamides