Type of diabetes and waist-hip ratio are important determinants of serum lipoprotein (a) levels in diabetic patients.
This cross-sectional study compared serum lipoprotein (a) [Lp(a)] concentrations in type 1 and type 2 diabetic subjects and examined the determinants of Lp(a) concentrations in both types of diabetes. Serum Lp(a) was measured in 26 type 1 and 107 type 2 diabetic patients and 126 non-diabetic controls. HbA(1c), fasting lipids and urinary albumin were also assayed. Lp(a) concentrations were higher in both type 1 and type 2 diabetic patients compared with controls (P<0.0001 and P<0.0001, respectively), and were higher in type 1 than type 2 diabetic patients (P<0.05). Waist-hip ratio (WHR) was an independent determinant of Lp(a) concentrations in both type 1 and type 2 diabetes.
Nawawi
Hapizah M
HM
Chemical Pathology Unit, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000, Kuala Lumpur, Malaysia. hapizah@mail.hukm.ukm.my
Muhajir
Musilawati
M
Kian
Yeo Chee
YC
Mohamud
Wan Nazaimoon Wan
WN
Yusoff
Khalid
K
Khalid
B A  K
BA
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001824:Body Constitution; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016011:Normal Distribution; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D008055:Lipids; D017270:Lipoprotein(a); D014280:Triglycerides