Cerebrospinal fluid penetration and pharmacokinetic/pharmacodynamic parameters of intravenously administered colistin in a case of multidrug-resistant Acinetobacter baumannii meningitis.
Described here is a case of meningitis caused by multidrug-resistant Acinetobacter baumannii susceptible only to colistin, which was treated successfully with intravenous colistin sulfomethate sodium (5 mg/kg/day). The levels of colistin in serum and cerebrospinal fluid and the pharmacokinetic/pharmacodynamic parameters of colistin were determined. In this case, intravenously administered colistin penetrated cerebrospinal fluid (25% of serum levels) at levels sustaining bactericidal concentrations.
Jiménez-Mejías
M E
ME
Service of Infectious Diseases, University Hospital Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Seville, Spain. mmejias@cica.es
Pichardo-Guerrero
C
C
Márquez-Rivas
F J
FJ
Martín-Lozano
D
D
Prados
T
T
Pachón
J
J
D000150:Acinetobacter / Q000187:drug effects*; D000151:Acinetobacter Infections / Q000188:drug therapy / Q000382:microbiology; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics / Q000627:therapeutic use; D003091:Colistin / Q000097:blood / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D018432:Drug Resistance, Multiple; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000382:microbiology*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D003091:Colistin