The age-related eye disease study: the results of the clinical trial.
The Age-Related Eye Disease Study (AREDS) is a multi-center study sponsored by the National Eye Institute to determine the natural history and risk factors associated with both cataract and age-related macular degeneration (AMD). AREDS incorporated a clinical trial to determine what role micro nutrients may play in the development and progression of cataracts and AMD. The micro nutrients studied were the antioxidants vitamins E,C, beta-carotene and zinc with copper. Participants were randomized to either antioxidants, mineral, a combination of antioxidants and minerals or placebo. The participants were categorized, by the presence of drusen and diagnosis of AMD into one of four groups: no AMD, early AMD, intermediate AMD or advanced AMD. They were followed for an average of 6.3 years. There was no statistically significant difference in the cataract trial between treatment and placebo. In the AMD trial groups, those at high risk of developing advanced AMD lowered their risk by about 25% when treated with the mega dosages of the combination of antioxidants and minerals.
Sackett
Catherine Stewart
CS
Wilmer Institute Woods, 265 600 North Wolfe Street, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
Schenning
Sherrie
S
D017677:Age Distribution; D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002386:Cataract / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D003300:Copper / Q000172:deficiency / Q000627:therapeutic use*; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D018977:Micronutrients / Q000627:therapeutic use*; D012307:Risk Factors; D012720:Severity of Illness Index; D014131:Trace Elements / Q000172:deficiency / Q000627:therapeutic use*; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D014810:Vitamin E / Q000627:therapeutic use*; D015032:Zinc / Q000172:deficiency / Q000627:therapeutic use*; D019207:beta Carotene / Q000172:deficiency / Q000627:therapeutic use*
D000975:Antioxidants; D018977:Micronutrients; D014131:Trace Elements; D019207:beta Carotene; D014810:Vitamin E; D003300:Copper; D015032:Zinc; D001205:Ascorbic Acid