Linkage mapping of sex-specific differences.
Most current linkage analyses assume identical fractions of meiotic recombination between homologous marker loci of the two sexes. This assumption is not realistic, because considerable sex-related differences have been observed in recombination fraction. In this paper, a general EM-based algorithm is presented to estimate sex-specific recombination fractions for a mixed set of molecular markers segregating differently in a full-sib family derived from two heterozygous parents. The asymptotic variances of the estimates of linkage specifically for each of the parents are evaluated using a numerical analysis based on information functions. This approach will have important implications for precise gene mapping based on sex-specific linkage maps.
Wu
Rongling
R
Department of Statistics, University of Florida, Gainesville, FL 32611, USA. rwu@stat.ufl.edu
Ma
Chang-Xing
CX
Wu
S S
SS
Zeng
Zhao-Bang
ZB
D000465:Algorithms; D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D011995:Recombination, Genetic / Q000235:genetics*; D012727:Sex Characteristics
D005819:Genetic Markers