title: Combined lidocaine 1% and hydroxypropyl methylcellulose 2.25% as a single anesthetic/ viscoelastic agent in phacoemulsification.
abstract: OBJECTIVE
  To evaluate the use of a mixture of hydroxypropyl methylcellulose 2.25% (HPMC) and lidocaine 1% (final concentrations) as a single viscoelastic/anesthetic agent to achieve proper anesthesia and viscoelastic properties during phacoemulsification.
  
  
  METHODS
  Department of Ophthalmology, Cairo University, Cairo, Egypt.
  
  
  METHODS
  This prospective randomized study comprised 70 eyes having routine phacoemulsification. Patients had the HPMC-lidocaine mixture (n = 35) or pure HPMC 2.25% (n = 35) injected before capsulorhexis and again before intraocular lens implantation. The results were evaluated by a pain/discomfort score postoperatively.
  
  
  RESULTS
  The difference in medians of the overall intraoperative pain/discomfort scores between the 2 groups was not statistically significant. However, mild pain/discomfort was reported by 60.0% in the pure HPMC group and by 31.4% in the HPMC-lidocaine mixture group. Moderate pain/discomfort was reported by 28.6% and 5.7%, respectively. The difference between the 2 groups was statistically significant (P =.001).
  
  
  CONCLUSIONS
  The use of a mixture of HPMC 2.25% and lidocaine 1% rather than a regular viscoelastic agent resulted in clinically and statistically significantly reduced pain/discomfort during phacoemulsification.
authors.affiliation: Department of Ophthalmology, Cairo University, Cairo, Egypt. gozreem@hotmail.com
authors.forename: Mohamed
authors.initials: M
authors.lastname: Hosny
authors.forename: Sherif Gamal
authors.initials: SG
authors.lastname: Eldin
authors.forename: Hisham
authors.initials: H
authors.lastname: Hosny
mesh_terms: D000328:Adult; D000772:Anesthesia, Local / Q000379:methods; D000779:Anesthetics, Local / Q000008:administration & dosage*; D019923:Capsulorhexis; D004359:Drug Therapy, Combination; D006801:Humans; D007785:Lactose / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D019654:Lens Implantation, Intraocular; D008012:Lidocaine / Q000008:administration & dosage*; D008747:Methylcellulose / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D010078:Oxazines; D010147:Pain Measurement; D017060:Patient Satisfaction; D018918:Phacoemulsification; D011446:Prospective Studies
chemical_list: D000779:Anesthetics, Local; D010078:Oxazines; D008747:Methylcellulose; D008012:Lidocaine; C071191:MK 458; D007785:Lactose