The synthesis of fatty acids in mitochondria, microsomes and supernatant of rat adipose tissue was studied after administration of U-(14)C(-) glucose. The major site of fatty acids synthesis was the supernatant in controls and the microsomes in insulin-treated animals. The action of insulin cannot be explained only by an increase of the intra-cellular penetration of glucose. An action on enzyme synthesis is probable.
Rous
S
S
Institut de Biochimie Médicale, Ecole de Médecine, Genève, Suisse
Bonini
F
F
Aubry
L
L