Effects of endoscopic variceal treatment on oesophageal function: a prospective, randomized study.
OBJECTIVE
Endoscopic methods are currently the most widely used techniques for the treatment of bleeding oesophageal varices (BOV). However, a number of complications may limit their usefulness. We conducted a prospective, randomized comparison of variceal ligation versus sclerotherapy in cirrhotics after the control of variceal haemorrhage to study the relative short-term risks of these two procedures with respect to oesophageal motility and gastro-oesophageal reflux.


METHODS
Seventy-three patients with established cirrhosis and an episode of variceal bleeding controlled by one session of endoscopic therapy were randomized to treatment with sclerotherapy or ligation until variceal eradication. In 60 of these patients, oesophageal manometry and 24-h intra-oesophageal pH monitoring were performed at inclusion and 1 month after variceal eradication.


RESULTS
After variceal eradication with sclerotherapy, peristaltic wave amplitude decreased from 76.2 +/- 14.7 mmHg to 61.6 +/- 17.7 mmHg (P = 0.0001), simultaneous contractions increased from 0% to 37.9% (P = 0.0008), and the percentage of time with pH < 4 increased from 1.60 +/- 0.25 to 4.91 +/- 1.16% in channel 1 (P = 0.0002) and from 1.82 +/- 0.27 to 5.69 +/- 1.37% in channel 2 (P = 0.0006). In contrast, the above parameters were not disturbed with ligation.


CONCLUSIONS
Our data define the advantages of ligation over sclerotherapy with respect to post-treatment oesophageal dysmotility and associated gastro-oesophageal reflux.
Viazis
Nikos
N
Second Departments of Gastroenterology, Athens University, Athens, Greece.
Armonis
Anastasios
A
Vlachogiannakos
Jiannis
J
Rekoumis
George
G
Stefanidis
Gerasimos
G
Papadimitriou
Nikos
N
Manolakopoulos
Spilios
S
Avgerinos
Alec
A
D004932:Esophageal and Gastric Varices / Q000503:physiopathology / Q000628:therapy*; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000628:therapy*; D016558:Hemostasis, Endoscopic; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008026:Ligation; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010528:Peristalsis; D011446:Prospective Studies; D015911:Sclerotherapy