Chemokines as novel therapeutic targets in inflammatory diseases.
Chemokines and their receptors are a large family of inflammatory molecules responsible for a number of biological functions, including the accumulation of leukocytes at tissue sites. Over the past 10 years, a number of studies have indicated a role for chemokines and chemokine receptors in the pathophysiology of several inflammatory diseases, examples of which are multiple sclerosis, atherosclerosis, rheumatoid arthritis, and gastrointestinal diseases including hepatic disease. For this reason, it is not surprising that modulation of their pharmacology could be a prime target for drug discovery. This commentary provides a brief synopsis of our current knowledge of the role of chemokines and their receptors in the inflammatory process, and highlights the pros and possibly cons of chemokine and chemokine receptor antagonism in the therapeutic approach to several inflammatory diseases.
Ajuebor
Maureen N
MN
Liver Unit, Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive, Calgary, Alberta, Canada T2N 4N1. ajuebor@ucalgary.ca
Swain
Mark G
MG
Perretti
Mauro
M
D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism*; D016503:Drug Delivery Systems; D015195:Drug Design; D016481:Helicobacter Infections / Q000378:metabolism*; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism*; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors / Q000378:metabolism*
D018925:Chemokines; D019707:Receptors, Chemokine