title: Accuracy of a new low-flow sidestream capnography technology in newborns: a pilot study.
abstract: OBJECTIVE
  To evaluate the accuracy of a new low-flow sidestream capnography technology and analyze components of the capnogram in mechanically ventilated newborns with and without pulmonary disease.
  
  
  METHODS
  Twenty patients were prospectively identified. Eligible infants were mechanically ventilated and had an indwelling arterial catheter. Two groups were identified: newborns who were receiving mechanical ventilation for pulmonary diseases, and newborns who were receiving postoperative mechanical ventilation for nonpulmonary conditions. End-tidal CO(2) (PetCO(2)) was measured for 1-minute pre- and post-arterial blood sampling, and PetCO(2) and PaCO(2) were compared for each patient. Eight quantitative waveform parameters were also measured on all patients.
  
  
  RESULTS
  Newborns in the pulmonary group (n=13) (persistent pulmonary hypertension of the newborn/meconium aspiration syndrome, respiratory distress syndrome, pneumonia) and newborns in the control group (n=7) were matched for birth weight, gestational age, and postnatal age. PetCO(2)-PaCO2 Gradient values were higher in the pulmonary group (7.4+/-3.3 mm Hg) than controls (3.4+/-2.4 mm Hg). Four waveform parameters (ascending slope, alveolar angle, alpha angle, descending angle) were identified, which independently differentiated patients with pulmonary disease from controls.
  
  
  CONCLUSIONS
  Low-flow capnography with Microstream technology accurately measured alveolar CO(2) in newborns without pulmonary disease, as demonstrated by normal PetCO(2)-PaCO(2) gradients. The measured PetCO(2)-PaCO(2) gradient, as expected, was significantly higher in newborns with pulmonary disease. We also identified four quantitative waveform parameters that may be useful in differentiating between mechanically ventilated newborn patients with and without lung disease.
authors.affiliation: Division of Newborn Medicine, Children's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Hagerty
authors.forename: Monica E
authors.initials: ME
authors.lastname: Kleinman
authors.forename: David
authors.initials: D
authors.lastname: Zurakowski
authors.forename: Aimee C
authors.initials: AC
authors.lastname: Lyons
authors.forename: Baruch
authors.initials: B
authors.lastname: Krauss
mesh_terms: D019296:Capnography / Q000379:methods*; D002245:Carbon Dioxide / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D008171:Lung Diseases / Q000628:therapy; D010100:Oxygen / Q000032:analysis; D010865:Pilot Projects; D011446:Prospective Studies; D015203:Reproducibility of Results; D012121:Respiration, Artificial
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen