title: Thorectandrols C, D, and E, new sesterterpenes from the marine sponge Thorectandra sp.
abstract: Extracts of the marine sponge Thorectandra sp. have been found to contain three new sesterterpenes, thorectandrols C (4), D (5), and E (6), together with the known compounds luffarin R (7), luffarin V (8), and palauolide (9). The structures were determined by extensive NMR spectral data analysis. Their relative stereochemistry was defined using NOE correlations and coupling constants, while CD data were used to suggest their absolute stereochemistry. Cytotoxicity data for compounds 4-9 as well as the previously reported compounds thorectandrols A and B and palauolol (1-3) against six or more human tumor cell lines are also reported.
authors.affiliation: Molecular Targets Drug Discovery Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
authors.forename: Romila D
authors.initials: RD
authors.lastname: Charan
authors.forename: Tawnya C
authors.initials: TC
authors.lastname: McKee
authors.forename: Michael R
authors.initials: MR
authors.lastname: Boyd
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001943:Breast Neoplasms; D002289:Carcinoma, Non-Small-Cell Lung; D016543:Central Nervous System Neoplasms; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007680:Kidney Neoplasms; D007938:Leukemia; D008175:Lung Neoplasms; D008545:Melanoma; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D019029:Palau; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; D013729:Terpenes; C455553:luffarin R; C455552:luffarin V; C455551:palauolide; C455548:thorectandrol C; C455549:thorectandrol D; C455550:thorectandrol E