The use of a supported base and strong cation exchange (SCX) chromatography to prepare a variety of structurally-diverse molecular libraries prepared by solution-phase methods.
The preparation of molecular libraries of aminomethylbiaryls, allylic amines, and ethanolamines using solution-phase methodology is described. In particular, the use of a solid-supported base reagent (PTBD resin) and strong cation exchange(SCX) resin to effect 'catch and release' purification across these diverse libraries is highlighted.
Organ
M G
MG
Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada. organ@yorku.ca
Dixon
C E
CE
Mayhew
D
D
Parks
D J
DJ
Arvanitis
E A
EA
D000478:Alkylation; D000588:Amines / Q000138:chemical synthesis*; D002412:Cations; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D020650:Combinatorial Chemistry Techniques; D004983:Ethanolamines / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis*; D012116:Resins, Plant / Q000737:chemistry; D012996:Solutions; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet
D000588:Amines; D002412:Cations; D004983:Ethanolamines; D007202:Indicators and Reagents; D011084:Polycyclic Aromatic Hydrocarbons; D012116:Resins, Plant; D012996:Solutions; D012997:Solvents