title: A new synthesis of N-alkyl 3-acetyl-4-methoxycarbonylmethyl-2-methyl-1,4-dihydropyridines utilizing sec-aminodienyl esters with acetylacetone.
abstract: The reactions of sec-aminodienyl esters 3 with acetylacetone (4) afforded N-alkyl 3-acetyl-4-methoxycarbonylmethyl-2-methyl-1,4-dihydropyridines 5 and enamines 6, providing a new azaelectrocyclization reaction.
authors.affiliation: Showa Pharmaceutical University, Machida, Tokyo, Japan. koike@ac.shoyaku.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Koike
authors.forename: Naoki
authors.initials: N
authors.lastname: Takeuchi
mesh_terms: D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D003500:Cyclization; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D011725:Pyridines