title: Biology of metastatic disease.
abstract: Metastasis development is a complex series of events involving the generation of new blood vessels, growth, invasion with breakdown of the host matrix, transport to other sites with adhesion, and subsequent invasion of the organ that hosts the metastasis. It is only recently that the molecular basis for these events has been studied, and the understanding of this process is now leading to the development of therapies that targets one or more of the components of this series of events.
authors.affiliation: Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
authors.forename: Harvey I
authors.initials: HI
authors.lastname: Pass
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002448:Cell Adhesion; D016207:Cytokines / Q000378:metabolism; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D009361:Neoplasm Invasiveness / Q000503:physiopathology* / Q000517:prevention & control; D009362:Neoplasm Metastasis / Q000503:physiopathology / Q000517:prevention & control; D009360:Neoplastic Cells, Circulating; D009389:Neovascularization, Pathologic; D019714:Tissue Inhibitor of Metalloproteinases / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D016207:Cytokines; D006133:Growth Substances; D019714:Tissue Inhibitor of Metalloproteinases; D066246:ErbB Receptors