A randomized controlled trial comparing artemether and quinine in the treatment of cerebral malaria in Bangladesh.
A randomized controlled trial on 51 patients receiving artemether and 54 patients receiving quinine was undertaken to compare the effectiveness of intramuscular artemether and parenteral quinine in the treatment of cerebral malaria in adults in Bangladesh. Case fatality, fever and parasite clearance times were not significantly different in the two treatment groups. Coma resolution time was significantly delayed in artemether recipients. Results of the study suggest that treatment with artemether is as effective as parenteral quinine in the treatment of cerebral malaria in adults.
Faiz
M A
MA
Department of Medicine, Chittagong Medical College, Chittagong-4000, Bangladesh.
Rahman
E
E
Hossain
M A
MA
Rahman
M R
MR
Yunus
E B
EB
Samad
R
R
Hossain
M A
MA
D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000077549:Artemether; D037621:Artemisinins; D001459:Bangladesh; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D016779:Malaria, Cerebral / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D011803:Quinine / Q000009:adverse effects / Q000627:therapeutic use*; D012717:Sesquiterpenes / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; D011803:Quinine; D000077549:Artemether