Signal transduction in development: holding the key.
The unrelated GSK-3 and CK1 families stand out among the protein kinases because of their phosphorylated substrate recognition sites. Two papers in the March 22nd issue of Cell highlight the importance of this priming phosphorylation for signal transduction during development.
Harwood
Adrian J
AJ
MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom.
D000595:Amino Acid Sequence; D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D038362:Glycogen Synthase Kinase 3; D008969:Molecular Sequence Data; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators; D051176:beta Catenin
D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051176:beta Catenin; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D038362:Glycogen Synthase Kinase 3