title: [Miliary induced by intravesical BCG immunotherapy for carcinoma of the bladder: CT Findings].
abstract: The authors describe the case of a patient presenting miliary involvement of the lung due to mycobacterium bovis after intravesical BCG administration. After initial transurethral resection, the patient was treated with immunotherapy by intravesical instillation of BCG and received 9 treatments without any problem. After the 10th treatment, the patient presented with cough and signs of urinary infection. At admission the chest radiograph showed a miliary pattern, better seen at high resolution CT, and using helical technique with the maximum intensity projection (MIP) reconstructions. MIP demonstrated to better advantage the well defined contours of the nodules, distributed evenly and randomly in the whole lung. After anti-TB treatment, the patient had regained full activity with persistence of the miliary pattern but a decreased number and size of nodules and calcification in some of them. This case illustrates a rare complication of intravesical immunotherapy, and points out the superiority of Sliding Thin Slab MIP (STS-MIP) compared with standard HRCT which allows a better detection of extent and follow-up of a military pattern, notably in moderate forms, by improvement of the anatomical resolution.
authors.affiliation: Service de radiologie, Hôpital de Versailles, 78157 Le Chesnay, France. fmignon@ch-versailles.fr
authors.forename: F
authors.initials: F
authors.lastname: Mignon
authors.forename: A
authors.initials: A
authors.lastname: Chevrière
authors.forename: B
authors.initials: B
authors.lastname: Mesurolle
authors.forename: M
authors.initials: M
authors.lastname: El Hajam
authors.forename: H
authors.initials: H
authors.lastname: Morel
authors.forename: P
authors.initials: P
authors.lastname: Lacombe
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D000283:Administration, Intravesical; D000368:Aged; D001500:BCG Vaccine / Q000009:adverse effects*; D006801:Humans; D007167:Immunotherapy; D008297:Male; D014057:Tomography, X-Ray Computed; D014391:Tuberculosis, Miliary / Q000209:etiology*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine