title: HLA profile of three ethnic groups living in the North-Western region of Russia.
abstract: HLA class II alleles were determined by PCR-SSO and PCR-SSP typing of DNA samples from 55 Nentsy, 81 Saami and 73 Pomor individuals from the North-European part of Russia. The results were compared with similar data from Russians. A high frequency of the DRB1*04-DQA1*0301-DQB1*0302 haplotype and a low frequency of the DRB1*11-DQA1*0501-DQB1*0301 haplotype, observed in all three ethnic groups, may indicate a common aboriginal component in their ancestry. Saami and Pomors displayed a similar pattern of allele and haplotype distribution, with the exception of the DRB1*04-DQA1*0304-DQB1*0301 haplotype, which was significantly higher among Saami compared Nentsy, Pomors and Russians. Nentsy individuals had a particularly high frequency of the DRB1*09-DQA1*0301-DQB1*0303 and the DRB1*12-DQA1*0501-DQB1*0301 haplotypes. Genetic distances and correspondence analysis show that Pomors have a close relationship with Norwegians and Finns, whereas Nentsy and Saami are more closely related to Oriental populations.
authors.affiliation: Northern State Medical University, Archangel, Russia. irinae@sanet.ru
authors.forename: I
authors.initials: I
authors.lastname: Evseeva
authors.forename: A
authors.initials: A
authors.lastname: Spurkland
authors.forename: E
authors.initials: E
authors.lastname: Thorsby
authors.forename: A
authors.initials: A
authors.lastname: Smerdel
authors.forename: L
authors.initials: L
authors.lastname: Tranebjaerg
authors.forename: M
authors.initials: M
authors.lastname: Boldyreva
authors.forename: E
authors.initials: E
authors.lastname: Groudakova
authors.forename: I
authors.initials: I
authors.lastname: Gouskova
authors.forename: L L
authors.initials: LL
authors.lastname: Alexeev
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D005802:Genes, MHC Class II; D006683:HLA-DQ Antigens / Q000235:genetics; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D012426:Russia / Q000208:ethnology
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains