title: Statin use and the risk of breast and prostate cancer.
abstract: BACKGROUND
  Laboratory data suggest that the cholesterol-lowering "statin" drugs may have chemopreventive potential against cancer at various sites, including breast and prostate. However, in one trial of pravastatin there was a significant excess of breast cancer in the treatment group. In the present study, we assessed the relation of statin use to the risk of breast and prostate cancer in our hospital-based Case-Control Surveillance Study of Drugs and Serious Illnesses.
  
  
  METHODS
  Cases were 1,132 women with breast cancer and 1,009 men with prostate cancer; controls were 1,331 women and 1,387 men admitted for conditions unrelated to statin use. We used multivariate unconditional logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for use of statins compared with no use.
  
  
  RESULTS
  The OR for breast cancer among statin users was 1.5 (95% CI = 1.0-2.3), largely accounted for by an OR of 1.8 (95% CI = 0.9-3.6) among cases with carcinoma in situ. Among invasive cases, the OR was 1.2 (95% CI = 0.7-2.0). The odds ratio for prostate cancer overall was 1.2 (95% CI = 0.8-1.7), and it was 1.4 (95% CI = 0.7-2.5) for Stage A.
  
  
  CONCLUSIONS
  The data from the present study do not support a protective effect of statins against breast or prostate cancer. Detection bias is a possible explanation for the higher ORs observed for carcinoma in situ or early-stage cancer as compared with more invasive cancer.
authors.affiliation: Slone Epidemiology Unit, Boston University School of Medicine, Brookline, MA 02446, USA. pcoogan@slone.bu.edu
authors.forename: Patricia F
authors.initials: PF
authors.lastname: Coogan
authors.forename: Lynn
authors.initials: L
authors.lastname: Rosenberg
authors.forename: Julie R
authors.initials: JR
authors.lastname: Palmer
authors.forename: Brian L
authors.initials: BL
authors.lastname: Strom
authors.forename: Ann G
authors.initials: AG
authors.lastname: Zauber
authors.forename: Samuel
authors.initials: S
authors.lastname: Shapiro
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors