Antiepileptic drug selection in pediatric epilepsy.
This review article presents information concerning treatment options for various pediatric epilepsy syndromes. The decisions made in the selection of antiepileptic drugs are deternined by a number of variables that include, but are exclusive of, risk of seizure recurrence, patient age, epilepsy syndrome, known drug reactions, and prognosis of the epilepsy syndrome. The review discusses issues pertinent to antiepileptic drug selection including simple pharmacokinetic principles, antiepileptic drug formulations, and information concerning clinical studies using some of the antiepileptic drugs. Information is provided concerning the issues of seizure recurrence. Suggested paradigms for antiepileptic drug selection for partial seizures are provided. A table of antiepileptic drug costs is provided for assistance in prescribing and advising families. Psychosocial issues pertinent to the treatment of children are discussed.
Crumrine
Patricia K
PK
Division of Child Neurology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, PA 15213-2583, USA. crum@pitt.edu
D000367:Age Factors; D000927:Anticonvulsants / Q000191:economics / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011379:Prognosis; D011788:Quality of Life; D012008:Recurrence; D013577:Syndrome; D016896:Treatment Outcome
D000927:Anticonvulsants