Immunoadsorption inferior to plasma exchange in a patient with chronic inflammatory demyelinating polyradiculoneuropathy.
Staphylococcal protein A immunoadsorption and plasma exchange were compared for treating chronic inflammatory demyelinating polyradiculoneuropathy. In a single patient, plasma exchange had a more beneficial effect than immunoadsorption on clinical outcome measures. Serum IgM antibody activity to peripheral nerve fell significantly following plasma exchange. Serum IgM and IgA fell more and IgG less after plasma exchange than after immunoadsorption. The superior efficacy of plasma exchange to immunoadsorption in this case may have been the result of removal of an IgM antibody.
Hadden
R D M
RD
Department of Neuroimmunology, Guy's King's and St Thomas' School of Medicine, London SE1, UK.
Bensa
S
S
Lunn
M P T
MP
Hughes
R A C
RA
D000328:Adult; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007163:Immunosorbent Techniques; D008297:Male; D010951:Plasma Exchange; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000628:therapy*; D013205:Staphylococcal Protein A / Q000276:immunology / Q000302:isolation & purification*; D016896:Treatment Outcome
D007070:Immunoglobulin A; D007075:Immunoglobulin M; D013205:Staphylococcal Protein A