Effect of hyperosmotic substances injected into the prostate of Wistar rats.
OBJECTIVE
To verify the effects produced by the injections of hyperosmotic substances into the prostate of Wistar rats as judged by gland weight, behavior, histologic changes, and systemic electrolytic alterations.


METHODS
A total of 42 Wistar rats were divided into five groups and treated in the following manner. In Group I (N = 6), the abdominal cavity was opened and closed. In Group II (N = 6), a needle was introduced into the each ventral lobes of the prostate gland. In Group III (N = 10), a 0.9% sodium chloride solution was injected into the each ventral lobe of the prostate gland. In Group IV (N = 10), a 20% NaCl solution was injected into the each ventral lobe of the prostate gland. In Group V (N = 10), a 50% glucose solution was injected into the each ventral lobe of the prostate gland. The following parameters were studied: histologic features of the ventral lobes of the prostate, the electronic weight of the parts utilized in the surgery, and the sodium and potassium concentrations.


RESULTS
The animals of Group V (50% glucose solution) were sacrificed after 60 days and showed a significant reduction in the weight of the ventral prostate lobes in comparison with the other groups (P = 0.05). There were important histologic changes in the groups which received hyperosmotic substances. After the 50% glucose injection, the potassium level increased temporarily.


CONCLUSIONS
The injection of 50% glucose solution produced significant alterations in the tissue structure, with reduction in prostatic weight. The electrolyte changes were transitory.
Lopes
de Lima Marcelo
de LM
Division of Urology, University of Campinas Medical Center-Unicamp, São Paulo, Brazil. mar.lima@cas.zaz.com.br
Ferreira
Ubirajara
U
Rodrigues
Netto Nelson
NN
D000818:Animals; D004195:Disease Models, Animal; D005947:Glucose / Q000008:administration & dosage*; D007267:Injections; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009994:Osmolar Concentration; D011467:Prostate / Q000187:drug effects* / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000628:therapy*; D051381:Rats; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*
D012462:Saline Solution, Hypertonic; D005947:Glucose