title: [Changes in chromatin organization during early development and carcinogenesis].
abstract: Similar changes in chromatin organization take place during development and carcinogenesis. The size of chromatin loop domains fixed on the nuclear skeleton (matrix) increased from 20 to approximately 200 kbp. These changes are accompanied by an increased size of replicons and altered specificity of loop attachment to the nuclear matrix. During carcinogenesis, inverse changes in the chromatin structure are observed, neoplastic cells are dedifferentiated and return to the initial state. In this review, we consider new experimental data on organization of the DFNA loops and nuclear matrix in embryogenesis and carcinogenesis.
authors.affiliation: Gene Expression Group, School of Biological Sciences, University of Manchester, Stopford Building, Oxford Rd, Manchester M13 9PT.
authors.forename: A
authors.initials: A
authors.lastname: Hair
authors.forename: S V
authors.initials: SV
authors.lastname: Razin
authors.forename: E S
authors.initials: ES
authors.lastname: Vasetskiĭ
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002843:Chromatin / Q000502:physiology* / Q000648:ultrastructure; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D005314:Embryonic and Fetal Development / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D009687:Nuclear Proteins / Q000378:metabolism
chemical_list: D002843:Chromatin; D009687:Nuclear Proteins; D004247:DNA; D004250:DNA Topoisomerases, Type II