title: Bedside testing with the new CoaguChek Pro activated clotting time assay in dialysis.
abstract: The objective of this study was to assess the analytical performance of CoaguChek Pro activated clotting time (ACT) assay using 2 lots versus Hemochron Celite and glass ACT regarding ACT values and correlations versus heparin levels. Determinations were performed using 4 CoaguChek Pro meters and 1 Hemochron 801 meter. Samples were collected during hemodialysis before, after start of heparinization, and 2 h later. Agreement between CoaguChek Pro ACT and Hemochron Celite was good (r = 0.82, slope = 1.12) and moderate with Hemochron glass (r = 0.83, slope = 0.97). Agreement between both CoaguChek Pro lots was r = 0.98. Agreement between the activators, Hemochron Celite, and glass was r = 0.73. Correlation between CoaguChek Pro ACT and heparin concentration was r = 0.88 and 0.94; for Hemochron the correlation was r = 0.75 (Celite) and r = 0.73 (glass). CoaguChek Pro ACT is therefore suitable for monitoring heparin administration during dialysis.
authors.affiliation: Dialysis Center, Heidelberg, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Bommer
authors.forename: Michael
authors.initials: M
authors.lastname: Schwab
mesh_terms: D006801:Humans; D019095:Point-of-Care Systems; D006435:Renal Dialysis; D014914:Whole Blood Coagulation Time