Lymphatic filariasis: new insights and prospects for control.
Although lymphatic filariasis remains among the major causes of disability among the tropical infectious diseases, dramatic advances have been made in the approach to its diagnosis, epidemiology and treatment, in our understanding of the molecular composition of the parasites that cause these infections, and in the factors underlying the pathology seen. Superimposing the tools of modern epidemiology, immunology, and molecular biology on field-based clinical trials has allowed the emergence of the concept of elimination of lymphatic filariasis. Much of the important new research emphasizes parasite development in the context of the host response, the importance of both the adult worm and other factors in the pathogenesis of lymphatic filarial disease, the role the Wolbachia endosymbiont holds as both a target for drug treatment and in inducing post-treatment reactions, and the various principles underlying the implementation of control programs.
Nutman
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Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA. tnutman@niaid.nih.gov
D000818:Animals; D004605:Elephantiasis, Filarial / Q000175:diagnosis / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D014958:Wuchereria bancrofti / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity