title: Transcription factor complexes.
abstract: Considerable progress has been made during the past year on structural studies of the eukaryotic and bacterial transcription factors that control RNA polymerase function via the formation of multiprotein complexes on promoter DNA. Recently determined structures include negative cofactor 2 recognizing a preformed TATA-box-binding protein-DNA binary complex, a dimer of BmrR bound to both DNA and tetra-phenylphosphonium, DNA-bound complexes of SarA and FadR, leukemia-associated AML1-CBFbeta-DNA ternary complexes and a SAP1-SRF-DNA ternary complex.
authors.affiliation: Laboratories of Molecular Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA. sburley@stromix.com
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Burley
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kamada
mesh_terms: D001419:Bacteria / Q000235:genetics; D001426:Bacterial Proteins; D050676:Core Binding Factor Alpha 2 Subunit; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000235:genetics; D008958:Models, Molecular; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism; D011518:Proto-Oncogene Proteins; D029702:Schizosaccharomyces pombe Proteins; D035181:TATA-Box Binding Protein; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; C098722:BmrR protein, bacteria; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; C493728:RUNX1 protein, human; C085981:Sap1 protein, S pombe; D029702:Schizosaccharomyces pombe Proteins; D035181:TATA-Box Binding Protein; D015534:Trans-Activators; D050656:Transcription Factor AP-2; D014157:Transcription Factors; C075995:down-regulator of transcription 1; D004247:DNA; D011494:Protein Kinases; C405628:serum response factor kinase