[Cerebral venous thrombosis and factor V Leiden mutation].
OBJECTIVE
To investigate the relationship between factor V Leiden mutation and cerebral venous thrombosis in China.


METHODS
20 patients and 50 controls of Chinese origin were studied by polymerase chain reaction followed by Mnl I restriction enzyme analysis.


RESULTS
The PCR products of all the people supervised were digested to three segments with the length of 37 bp, 67 bp, and 116 bp. No factor V Leiden mutation was found in any subjects.


CONCLUSIONS
Factor V Leiden mutation is not a crucial risk factor of cerebral venous thrombosis.
Meng
Qiang
Q
Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
Pu
Chuanqiang
C
D000328:Adult; D002539:Cerebral Arterial Diseases / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012307:Risk Factors; D020246:Venous Thrombosis / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V