title: Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation.
abstract: Malignant mixed Mullerian tumors (MMMTs) are rare neoplasms. We report the clinical, pathologic, and immunohistochemical features of an MMMT primary of uterine cervix. This lesion was composed of a poorly differentiated epithelial component (cytokeratin positive) and a spindle cell component (vimentin positive) with heterologous (myoblastic) differentiation (focal 1A4 positive). There were also cells with neuroendocrine features that expressed S-100 and chromogranin A. Along with a brief review of this amazing neoplasm, some histogenetic concepts relevant to this case are discussed. To our knowledge this is the first report of a malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation.
authors.affiliation: Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo (FMRP/USP), Avenida Bandeirantes, s/n-Campus Universitário Monte Alegre, CEP 14048-900, Ribeirão Preto-SP, São Paulo, Brazil. ardsilva@rpa.fmrp.usp.br
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ribeiro-Silva
authors.forename: A
authors.initials: A
authors.lastname: Novello-Vilar
authors.forename: A M
authors.initials: AM
authors.lastname: Cunha-Mercante
authors.forename: L A L
authors.initials: LA
authors.lastname: De Angelo Andrade
mesh_terms: D000368:Aged; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D018198:Mixed Tumor, Malignant / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D018200:Mixed Tumor, Mullerian / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy