Developmental malformations in cerebral structures in "endogenous psychoses".
The last decades have revealed several structural deviances in patients with so called "endogenous psychoses". Reasonably well established are the enlargement of the lateral ventricles and subtle structural deficits in temporobasal and orbital frontal structures (hypofrontality) in a majority of schizophrenic patients. It is the aim of this investigation to examine the cytoarchitecture of these important central structures, namely the entorhinal region and the orbitofrontal cortex (Brodmann area 11) which have been under meticulous investigation in our laboratories over decades (for review: Beckmann, 2000).
Beckmann
H
H
Department of Psychiatry and Psychotherapy, University of Würzburg, Federal Republic of Germany. beckmann@mail.uni-wuerzburg.de
Senitz
D
D
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D018728:Entorhinal Cortex / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D009421:Nervous System Malformations / Q000473:pathology* / Q000503:physiopathology; D009474:Neurons / Q000473:pathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011618:Psychotic Disorders / Q000473:pathology* / Q000503:physiopathology; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology