Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia?
Eighty-six patients with tumour induced hypercalcaemia were randomised to 600, 900, 1200 or 1500 mg of intravenous clodronate, according to post hydration serum calcium levels. Sixty-seven were evaluable for response. The overall response rate was 49.3% (95% CI: 36.8-61.8) with no significant difference in response rates, i.e. achievement of normocalcaemia at days 6-9 (corrected serum calcium < or =2.6 mmol l(-1)) across all groups.
Shah
S
S
Department of Palliative Medicine, The Royal Marsden NHS Trust, Sutton SM2 5PT, Surrey, UK.
Hardy
Janet
J
Rees
E
E
Ling
J
J
Gwilliam
B
B
Davis
C
C
Broadley
K
K
A'Hern
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000097:blood; D004002:Clodronic Acid / Q000008:administration & dosage* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000150:complications*
D004002:Clodronic Acid; D002118:Calcium