[Effect of angiotensin II on potassium channels of ischemic ventricular myocytes of the guinea pig].
The experiments were carried out on guinea pig isolated ventricular myocytes by using whole-cell patch clamp. The effects of angiotensin II (Ang II) on potassium ion channels of acute ischemic myocytes were observed. Whole-cell patch clamp recordings showed that physiological potassium current, including delayed rectifier potassium current and inward rectifier potassium current were inhibited under the condition of simulated ischemia, and then further inhibited by treatment with Ang II. ATP-sensitive potassium currents were increased under simulated ischemia and were further enhanced by Ang II treatment.
Wang
Wen-Wei
WW
Department of Physiology, Medical Center of Fudan University, Shanghai 200032. wangwenwei66@yahoo.com
Zhu
Yi-Chun
YC
Yao
Tai
T
Zheng
Ping
P
Gong
Qian-Ling
QL
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D005260:Female; D006168:Guinea Pigs; D006352:Heart Ventricles / Q000166:cytology* / Q000187:drug effects; D008297:Male; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology*; D032383:Myocytes, Cardiac / Q000187:drug effects*; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology
D015221:Potassium Channels; D000804:Angiotensin II