New cytotoxic analogues of annonaceous acetogenins.
A series of new acetogenin analogues incorporating a central catechol moiety instead of the tetrahydrofuran ring(s) have been prepared and tested against L1210 leukemia cells. Although less potent than bullatacinone, which has the same terminal lactone, these compounds display interesting cell cycle effects.
Rodier
S
S
Laboratoire de Synthèse et Réactivité des Substances Naturelles, Université de Poitiers et CNRS, France.
Le Huerou
Y
Y
Renoux
B
B
Doyon
J
J
Renard
P
P
Pierré
A
A
Gesson
J P
JP
Grée
R
R
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000494:pharmacology*; D002396:Catechols / Q000737:chemistry; D002453:Cell Cycle / Q000187:drug effects; D005233:Fatty Alcohols / Q000138:chemical synthesis / Q000494:pharmacology*; D005434:Flow Cytometry; D007202:Indicators and Reagents; D007939:Leukemia L1210 / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D002396:Catechols; D005233:Fatty Alcohols; D007202:Indicators and Reagents; D015107:4-Butyrolactone