Scleroderma and malignancy. Mechanisms of interrelationship.
The association of scleroderma and malignancy has been a source of controversy during recent years. Several mechanisms of interrelationship have been suggested in earlier reports. Recent long-term studies suggest an increased association-ratio of scleroderma and malignancy. However, the underlying mechanisms remain elusive. This paper reviews the mechanisms described in earlier studies and discusses their possible pathogenetic meaning for the interrelationship and the pathogenesis of scleroderma and neoplasia.
Wenzel
Joerg
J
Department of Dermatology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. joerg.wenzel.ukb.uni-bonn.de
D000367:Age Factors; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D015551:Autoimmunity; D001761:Bleomycin / Q000009:adverse effects; D001943:Breast Neoplasms / Q000209:etiology; D016207:Cytokines / Q000502:physiology; D004198:Disease Susceptibility; D015802:HLA-DR2 Antigen / Q000032:analysis*; D006801:Humans; D007111:Immunity, Cellular; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000532:radiotherapy; D010257:Paraneoplastic Syndromes / Q000473:pathology; D012189:Retrospective Studies; D012595:Scleroderma, Systemic / Q000139:chemically induced / Q000209:etiology*; D012701:Serotonin / Q000502:physiology; D014364:Tryptophan / Q000502:physiology
D000903:Antibiotics, Antineoplastic; D016207:Cytokines; D015802:HLA-DR2 Antigen; D001761:Bleomycin; D012701:Serotonin; D014364:Tryptophan