Maternal floor infarction of the placenta: association with central nervous system injury and adverse neurodevelopmental outcome.
OBJECTIVE
To compare cranial ultrasound studies and neurodevelopmental outcome of preterm infants affected by maternal floor infarction (MFI) of the placenta to gestational age-matched controls over an 8-year period from a single institution.


METHODS
Retrospective case/control study.


RESULTS
Compared to gestational age-matched controls, infants born to mothers with MFI had a higher incidence of CNS injury on neonatal cranial ultrasound examinations and at follow-up were more likely to have a suspicious or abnormal neurologic examination. MFI cases had lower developmental scores in all areas tested and were more likely to have neurodevelopmental impairment.


CONCLUSIONS
Infants born to mothers with MFI should have serial neonatal cranial ultrasound examinations to detect CNS injury and neurodevelopmental assessment during early childhood.
Adams-Chapman
Ira
I
Departments of Pediatrics/Division of Neonatology, Pathology and Reproductive Medicine, University of California at San Diego, San Diego, CA, USA.
Vaucher
Yvonne E
YE
Bejar
Raul F
RF
Benirschke
Kurt
K
Baergen
Rebecca N
RN
Moore
Thomas R
TR
D000328:Adult; D016022:Case-Control Studies; D002490:Central Nervous System / Q000293:injuries; D002493:Central Nervous System Diseases / Q000209:etiology*; D002658:Developmental Disabilities; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology*; D007238:Infarction / Q000150:complications*; D020300:Intracranial Hemorrhages / Q000209:etiology; D008297:Male; D010920:Placenta / Q000098:blood supply*; D021041:Placental Circulation; D011247:Pregnancy; D011256:Pregnancy Outcome; D012886:Skull / Q000000981:diagnostic imaging; D014463:Ultrasonography