title: Highly potent inhibitors of TNF-alpha production. Part 1: Discovery of chemical leads.
abstract: The discovery of 2-acylamino-2-phenylethyl disodium phosphates and as structurally novel inhibitors of TNF-alpha production is reported. Structure-activity relationships (SARs) are also discussed.
authors.affiliation: Fukui Research Institute, Ono Pharmaceutical Co., Ltd., Technoport, Yamagishi, Mikuni, Sakai, 913-8638, Fukui, Japan
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Matsui
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nishita
authors.forename: Satoshi
authors.initials: S
authors.lastname: Itadani
authors.forename: Shingo
authors.initials: S
authors.lastname: Nakatani
authors.forename: Nagashige
authors.initials: N
authors.lastname: Omawari
authors.forename: Masaru
authors.initials: M
authors.lastname: Sakai
authors.forename: Shuichi
authors.initials: S
authors.lastname: Nakazawa
authors.forename: Akihito
authors.initials: A
authors.lastname: Ogata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohno
authors.forename: Takaaki
authors.initials: T
authors.lastname: Obata
authors.forename: Hisao
authors.initials: H
authors.lastname: Nakai
authors.forename: Masaaki
authors.initials: M
authors.lastname: Toda
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001596:Benzylamines / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010710:Phosphates / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000276:Adjuvants, Immunologic; D001596:Benzylamines; D008070:Lipopolysaccharides; D010710:Phosphates; D014409:Tumor Necrosis Factor-alpha