title: Steele-Richardson-Olszewski-syndrome: the relation of dopamine D2 receptor binding and subcortical lesions in MRI.
abstract: We compared (123)I-iodobenzamide single photon emission computed tomography (IBZM-SPECT) for imaging of striatal dopamine D(2) receptors in vivo, and MRI in 32 patients with the clinical diagnosis of progressive supranuclear palsy (PSP). We found a significant inter-dependence of reduction of specific striatal IBZM binding indicative of striatal degeneration and of the absence of multiple signal hyperintensities in MRI; age had no influence neither on IBZM binding nor on signal hyperintensities. We conclude that the presence of multiple signal hyperintensities should raise doubt on the correct clinical diagnosis.
authors.affiliation: Department of Neurology, Klinikum Gorsshadern, University of Munich, Federal Republic of Germany.
authors.forename: G
authors.initials: G
authors.lastname: Arnold
authors.forename: J
authors.initials: J
authors.lastname: Schwarz
authors.forename: K
authors.initials: K
authors.lastname: Tatsch
authors.forename: E
authors.initials: E
authors.lastname: Kraft
authors.forename: T
authors.initials: T
authors.lastname: Wächter
authors.forename: O
authors.initials: O
authors.lastname: Bandmann
authors.forename: W H
authors.initials: WH
authors.lastname: Oertel
mesh_terms: D000368:Aged; D016001:Confidence Intervals; D003342:Corpus Striatum / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007462:Iodobenzenes / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D008636:Mesencephalon / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis* / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon / Q000706:statistics & numerical data
chemical_list: D007462:Iodobenzenes; D019275:Radiopharmaceuticals; D017448:Receptors, Dopamine D2; C426805:idobenzamide