[Effects of intracerebroventricular injection of angiotensin II on blood   pressure and discharges of habenula nucleus cardiovascular neurons].
The effects of icv and iontophoretic application of angiotensin II (A II) and Sar(1),Thr(8) -A II (ST-A II) on blood pressure (BP) and electroneurogram (ENG) of habenula nucleus (Hb) cardiovascular neurons were studied in stress induced hypertensive (SIH) and normotensive rats. Increase and decrease of BP could be induced respectively by icv of A II (20 microgram) and ST A II (20 microgram), to a greater extent in SIH than in the normotensive group. Icv A II also increased the ENG of MHb cardiovascular neurons in both the groups, but the increase was significantly greater in SIH group than in the normotensive one. Iontophoretic application of A II increased the ENG of Hb cardiovascular neurons in both the groups and the increase was also significantly greater in SIH than in the normotensive group. On the other hand, iontophoretic application of ST-A II inhibited the ENG of Hb cardiovascular neurons in the two groups and the inhibition was markedly greater in SIH than in the normotensive rats. It is suggested that central A II is involved in SIH and Hb cardiovascular neurons of SIH show an enhanced sensitivity to A II.
Cui
J J
JJ
Department of Physiology, Henan Medical University, Zhengzhou 450052, China. cuijj@public2.zz.ha.cn
Wang
S
S
Zhang
Y
Y
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004594:Electrophysiology; D005260:Female; D019262:Habenula / Q000502:physiology*; D006973:Hypertension / Q000503:physiopathology; D007276:Injections, Intraventricular; D007478:Iontophoresis; D008297:Male; D009474:Neurons / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D000804:Angiotensin II