title: Severe hyperphosphataemia and associated electrolyte and metabolic derangement following the administration of sodium phosphate for bowel preparation.
abstract: Sodium phosphate is widely used as an effective bowel preparation agent. It is used in smaller volumes, leading to improved patient tolerance. Although it is generally safe, cases of severe hyperphosphataemia following sodium phosphate administration have been reported in the literature. The common risk factors identified are advanced age, impaired renal function, impaired colonic motility and multiple doses. However, many doctors remain unaware of the dangers associated with this agent. We report six cases of severe electrolyte and metabolic derangement due to sodium phosphate bowel preparation: two patients had delayed awakening from general anaesthesia, and four patients suffered life-threatening consequences.
authors.affiliation: Department of Anaesthesiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore. Hui_Ling_Tan@notes.ttsh.gov.sg
authors.forename: H L
authors.initials: HL
authors.lastname: Tan
authors.forename: Q Y
authors.initials: QY
authors.lastname: Liew
authors.forename: S
authors.initials: S
authors.lastname: Loo
authors.forename: R
authors.initials: R
authors.lastname: Hawkins
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000762:Anesthesia Recovery Period; D002400:Cathartics / Q000009:adverse effects*; D003128:Coma / Q000139:chemically induced*; D004232:Diuretics / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005767:Gastrointestinal Diseases / Q000601:surgery; D006801:Humans; D006973:Hypertension / Q000150:complications; D008875:Middle Aged; D010710:Phosphates / Q000009:adverse effects* / Q000097:blood*; D011300:Preoperative Care; D012307:Risk Factors
chemical_list: D002400:Cathartics; D004232:Diuretics; D010710:Phosphates; C018279:sodium phosphate