title: Effectiveness of washed platelet concentrate and red cell transfusions for a patient with anhaptoglobinemia with antihaptoglobin antibody.
abstract: A 71-year-old Japanese male with myelodysplastic syndrome progressing to overt leukaemia and hepatocellular carcinoma developed dyspnea and urticaria immediately after infusion of platelet concentrate (PC). He exhibited an identical reaction following blood transfusion. Serum haptoglobin was undetectable. The patient was determined to be homozygous for Hp(del) by polymerase chain reaction (PCR). Antibody to haptoglobin was detected by enzyme-linked immunosorbent assay (ELISA) and Western blot analysis. No antibodies against human leucocyte antigen (HLA) or platelet-specific antigens were detected. Washed PC and washed red blood cells were effective in preventing the transfusion-related anaphylactoid reactions.
authors.affiliation: Department of Clinical Hematology and Diagnostics, Osaka City University, Graduate School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nishiki
authors.forename: M
authors.initials: M
authors.lastname: Hino
authors.forename: T
authors.initials: T
authors.lastname: Kumura
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: T
authors.initials: T
authors.lastname: Yamane
authors.forename: T
authors.initials: T
authors.lastname: Takubo
authors.forename: N
authors.initials: N
authors.lastname: Tatsumi
authors.forename: S
authors.initials: S
authors.lastname: Kitagawa
authors.forename: T
authors.initials: T
authors.lastname: Kamitani
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: E
authors.initials: E
authors.lastname: Shimada
authors.forename: T
authors.initials: T
authors.lastname: Juji
authors.forename: S
authors.initials: S
authors.lastname: Iida
mesh_terms: D000368:Aged; D000707:Anaphylaxis / Q000209:etiology / Q000276:immunology; D017707:Erythrocyte Transfusion / Q000009:adverse effects* / Q000592:standards; D017353:Gene Deletion; D006242:Haptoglobins / Q000172:deficiency* / Q000235:genetics / Q000276:immunology; D006720:Homozygote; D006801:Humans; D007518:Isoantibodies / Q000097:blood; D008297:Male; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000628:therapy; D017713:Platelet Transfusion / Q000009:adverse effects* / Q000592:standards
chemical_list: D006242:Haptoglobins; D007518:Isoantibodies