RNA-mediated virus resistance.
Post-transcriptional gene silencing is an RNA degradation mechanism that can be induced by viruses. Recent evidence indicates that silencing may also be involved in virus synergism, tissue limitation of virus spread, non-host resistance, virus transmission through seeds and in more general mechanisms of defense such as that mediated by salicylic acid. The analysis of Arabidopsis mutants, and of viruses carrying silencing suppressors, has led to a greater understanding of post-transcriptional gene silencing pathways. Much still remains to be discovered, however, not least to allow the successful exploitation of gene silencing in conferring pathogen resistance to transgenic plants.
Vazquez Rovere
Cecilia
C
Instituto de Biotecnología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, Instituto Nacional de Tecnología Agropecuaria, C.C.25, B1712WAA Castelar, Argentina. cvazquez@cicv.inta.gov.ar
del Vas
Mariana
M
Hopp
H Esteban
HE
D020868:Gene Silencing; D005818:Genetic Engineering / Q000379:methods; D010942:Plant Viruses / Q000235:genetics* / Q000472:pathogenicity; D030821:Plants, Genetically Modified / Q000235:genetics* / Q000821:virology; D012323:RNA Processing, Post-Transcriptional