title: Hereditary, focal, transgressive palmoplantar keratoderma with associated clinical findings: a new entity?
abstract: We report on a 24-year-old male originating from Yugoslavia with a focal, transgressive palmoplantar keratoderma presumably inherited as an autosomal recessive trait. Associated clinical findings were hyperkeratotic lichenoid papules on the knees and elbows, psoriasis-like lesions in the groins and on the scalp, a spotty or reticulate hyperpigmentation of the face, trunk and extremities and a partial alopecia of the left eyebrow and eyelashes. The patient's sister was affected by similar but less pronounced cutaneous changes. Although our case shares some similarities with other hereditary palmoplantar keratodermas there remain substantial differences. We therefore believe this case to represent a new entity.
authors.affiliation: Division of Special and Environmental Dermatology, Department of Dermatology, University of Vienna Medical School, Währinger Gürtel 18-20, A-1090 Vienna, Austria. a.tanew@akh-wien.ac.at
authors.forename: A
authors.initials: A
authors.lastname: Tanew
authors.forename: E
authors.initials: E
authors.lastname: Diridl
authors.forename: F
authors.initials: F
authors.lastname: Breier
authors.forename: P H
authors.initials: PH
authors.lastname: Itin
authors.forename: K
authors.initials: K
authors.lastname: Rappersberger
authors.forename: H
authors.initials: H
authors.lastname: Hönigsmann
mesh_terms: D000328:Adult; D000505:Alopecia / Q000235:genetics* / Q000473:pathology; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D015603:Keratinocytes / Q000648:ultrastructure; D007645:Keratoderma, Palmoplantar / Q000235:genetics* / Q000473:pathology; D008297:Male; D010375:Pedigree; D010859:Pigmentation Disorders / Q000235:genetics* / Q000473:pathology; D013577:Syndrome