title: Axillary node status in breast cancer patients prior to surgery by imaging with Tc-99m humanised anti-PEM monoclonal antibody, hHMFG1.
abstract: In early breast cancer axillary nodes are usually impalpable and over 50% of such patients may have an axillary clearance when no nodes are involved. This work identifies axillary node status by imaging with a Tc-99m radiolabelled anti-Polymorphic Epithelial Mucin, humanised monoclonal antibody (human milk fat globule 1), prior to surgery in 30 patients. Change detection analysis of image data with probability mapping is undertaken. A specificity of 93% and positive predictive value of 92% (both 100% if a second cancer in the axilla with negative nodes is considered) were found. A strategy for combining negative imaging with the sentinel node procedure is presented.
authors.affiliation: Department of Nuclear Medicine, St Bartholomew's Hospital, London EC1A 7BE, UK.
authors.forename: A R
authors.initials: AR
authors.lastname: Al-Yasi
authors.forename: M J
authors.initials: MJ
authors.lastname: Carroll
authors.forename: D
authors.initials: D
authors.lastname: Ellison
authors.forename: M
authors.initials: M
authors.lastname: Granowska
authors.forename: S J
authors.initials: SJ
authors.lastname: Mather
authors.forename: C A
authors.initials: CA
authors.lastname: Wells
authors.forename: R
authors.initials: R
authors.lastname: Carpenter
authors.forename: K E
authors.initials: KE
authors.lastname: Britton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001940:Breast / Q000000981:diagnostic imaging; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008875:Middle Aged; D018396:Mucin-1 / Q000276:immunology*; D016719:Radioimmunodetection; D013667:Technetium
chemical_list: D018396:Mucin-1; D013667:Technetium