Identification of a novel HLA-B*07 allele--HLA-B*0726.
We describe here, the identification of a novel HLA-B*07 allele named HLA-B*0726. This allele was found in a Caucasian individual serologically typed as HLA-B7, B35. Novel DNA probe patterns for the HLA-B*07 allele were found using HLA-B specific reverse sequence-specific oligonucleotide probe (SSOP) and sequence-specific primer (SSP) typing. DNA sequencing demonstrated the presence of a new HLA-B*07 sequence variant encoding a single nucleotide substitution from a G to a T at nucleotide 539 in exon 3. This results in an amino acid substitution from arginine to leucine at residue 156 in exon 3.
Herbut
B
B
Tissue Typing Laboratory, Calgary Laboratory Services, Foothills Medical Centre, Calgary, Canada. barbara.herbut@crha-health.ab.ca
Woodman
R
R
Kowalick
L
L
Malkki
M
M
Petersdorf
E W
EW
McKenna
R
R
D000483:Alleles; D001483:Base Sequence; D015235:HLA-B Antigens / Q000235:genetics*; D015793:HLA-B7 Antigen; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D020539:Sequence Analysis, Protein; D044465:White People / Q000235:genetics
D015235:HLA-B Antigens; C425023:HLA-B*07 antigen; C466443:HLA-B*07:26 antigen; D015793:HLA-B7 Antigen