title: The chromosome 1;11 translocation provides the best evidence supporting genetic etiology for schizophrenia and bipolar affective disorders.
abstract: Genetics is assumed to cause susceptibility to psychosis, but no major locus has been identified. These disorders cosegregate with a chromosome 1;11 translocation in a Scottish pedigree where 50% of the carriers are diseased. A genetic model originally proposed to explain the basis of these illnesses predicts such an outcome.
authors.affiliation: Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, Frederick, Maryland 21702, USA. klar@ncifcrf.gov
authors.forename: Amar J S
authors.initials: AJ
authors.lastname: Klar
mesh_terms: D001714:Bipolar Disorder / Q000209:etiology / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D012559:Schizophrenia / Q000209:etiology / Q000235:genetics*; D014178:Translocation, Genetic