Regulation of plasma adenosine levels in normal pregnancy.
The aim of this study was to investigate the possible mechanism of the regulation of plasma adenosine concentration [ADO] in normal pregnancy. We measured the activities of circulating enzymes that are involved in the production and metabolism of adenosine, and plasma [ADO] in nonpregnant (n = 14) and normal pregnant women (n = 14) in the third trimester. In pregnant women, the activity of plasma 5'-nucleotidase and plasma [ADO] were significantly elevated and plasma adenosine deaminase activity was significantly reduced. Enzymatic activities of both plasma enzymes appear to be changed in a way that would favor increased adenosine concentrations.
Yoneyama
Yoshio
Y
Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan. yoshi-1@nms.ac.jp
Sawa
Rintaro
R
Suzuki
Shunji
S
Ishino
Hiroshi
H
Miura
Atsushi
A
Kuwabara
Yoshimitsu
Y
Kuwajima
Toyohiko
T
Ito
Naoko
N
Kiyokawa
Yasuko
Y
Otsubo
Yasuo
Y
Araki
Tsutomu
T
D015720:5'-Nucleotidase; D000241:Adenosine / Q000097:blood*; D000243:Adenosine Deaminase / Q000097:blood; D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*
D015720:5'-Nucleotidase; D000243:Adenosine Deaminase; D000241:Adenosine