title: Differences in postoperative morbidity rates, including infection and dry socket, and differences in the healing process after mandibular third molar surgery in patients receiving 1-day or 3-day prophylaxis with lenampicillin.
abstract: The aim of this study was to examine the effect of antibiotic prophylaxis for mandibular third molar surgery from the viewpoint of the duration of administration. A comparative study was conducted on postoperative infection, dry socket, and the healing process in 178 healthy patients receiving 1-day or 3-day prophylaxis with lenampicillin (LAPC; 1.5 g/day). Postoperative infection developed in only 1 (1.1%) of the 91 patients in the 3-day group, while there was no patient with infection in the 87 patients in the 1-day group. Dry socket developed in 8.0% of the 87 patients in the 1-day group and in 7.7% of the 91 patients in the 3-day group. However, the incidence of these complications, in relation to the degree of impaction of the molars, did not significantly differ between the 1-day and 3-day groups. Scores indicating clinical symptoms for the 7 days after surgery also reflected no significant difference between the groups, irrespective of the degree of impaction. These results suggest that 1-day therapy with LAPC in our regimen may at least be recommended as a prophylaxis for mandibular third molar surgery in medically healthy patients.
authors.affiliation: Department of Dentistry, Hyogo Prefectural Staff Health Center, 5-10-1 Shimoyamate-dori, Chuo-ku, Kobe, Hyogo 650-8567, Japan. takashi3@basil.ocn.ne.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshii
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hamamoto
authors.forename: Shigetada
authors.initials: S
authors.lastname: Muraoka
authors.forename: Shungo
authors.initials: S
authors.lastname: Furudoi
authors.forename: Takahide
authors.initials: T
authors.lastname: Komori
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001424:Bacterial Infections / Q000453:epidemiology*; D002648:Child; D004368:Dry Socket / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008964:Molar, Third / Q000601:surgery*; D009017:Morbidity; D011183:Postoperative Complications / Q000453:epidemiology*
chemical_list: D000667:Ampicillin; C045384:lenampicillin