title: Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase.
abstract: Estrogen receptor and c-Myc are frequently overexpressed during breast cancer progression but are downregulated in many aggressive forms of the disease. High levels of the EphA2 tyrosine kinase are consistently found in the most aggressive breast cancer cells, and EphA2 overexpression can increase metastatic potential. We demonstrate, herein, that estrogen and Myc negatively regulate EphA2 expression in mammary epithelial cells. These data reveal EphA2 as a downstream target of estrogen and Myc and suggest a mechanism by which estrogen and Myc may regulate breast cancer.
authors.affiliation: Department of Basic Medical Sciences, Purdue University Cancer Center, West Lafayette, Indiana 47907, USA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Zelinski
authors.forename: Nicole Dodge
authors.initials: ND
authors.lastname: Zantek
authors.forename: Jennifer
authors.initials: J
authors.lastname: Walker-Daniels
authors.forename: Mette A
authors.initials: MA
authors.lastname: Peters
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Taparowsky
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kinch
mesh_terms: D001940:Breast / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism*; D002460:Cell Line; D004847:Epithelial Cells / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000235:genetics* / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism*; D036104:Receptor, EphA2; D011960:Receptors, Estrogen / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D004967:Estrogens; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D011960:Receptors, Estrogen; D004958:Estradiol; D020794:Receptor Protein-Tyrosine Kinases; D036104:Receptor, EphA2