Associations between hOGG1 sequence variants and prostate cancer susceptibility.
8-Hydroxyguanine is a mutagenic base lesion produced by reactive oxygen species. The hOGG1 gene encodes a DNA glycosylase/AP lyase that can suppress the mutagenic effects of 8-hydroxyguanine by catalyzing its removal from oxidized DNA. A population-based (245 cases and 222 controls) and family-based (159 hereditary prostate cancer families) association study was performed to test the hypothesis that sequence variants of hOGG1 increase susceptibility to prostate cancer. We found that the genotype frequency of two sequence variants (11657A/G and Ser326Cys) was significantly different between cases and controls. The association with 11657A/G is confirmed and strengthened by our family-based association study. These results suggest that sequence variants in this gene are associated with prostate cancer risk, presumably through defective DNA repair function of hOGG1.
Xu
Jianfeng
J
Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.
Zheng
Siqun L
SL
Turner
Aubrey
A
Isaacs
Sarah D
SD
Wiley
Kathy E
KE
Hawkins
Gregory A
GA
Chang
Bao-li
BL
Bleecker
Eugene R
ER
Walsh
Patrick C
PC
Meyers
Deborah A
DA
Isaacs
William B
WB
D016022:Case-Control Studies; D043382:DNA-Formamidopyrimidine Glycosylase; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D009699:N-Glycosyl Hydrolases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*
D009699:N-Glycosyl Hydrolases; D043382:DNA-Formamidopyrimidine Glycosylase