title: Current progress on esterases: from molecular structure to function.
abstract: This article reports on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 2001 Experimental Biology meeting. Current developments in molecular-based studies into the structure and function of cholinesterases, carboxylesterases, and paraoxonases are described. This article covers mechanisms of regulation of gene expression of the various esterases by developmental factors and xenobiotics, as well as the interplay between physiological and chemical regulation of enzyme activity.
authors.affiliation: Biomedical Research Institute, Chiba University, Chiba, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Satoh
authors.forename: Palmer
authors.initials: P
authors.lastname: Taylor
authors.forename: William F
authors.initials: WF
authors.lastname: Bosron
authors.forename: Sonal P
authors.initials: SP
authors.lastname: Sanghani
authors.forename: Masakiyo
authors.initials: M
authors.lastname: Hosokawa
authors.forename: Bert N
authors.initials: BN
authors.lastname: La Du
mesh_terms: D000818:Animals; D004950:Esterases / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D019143:Evolution, Molecular; D020869:Gene Expression Profiling; D006801:Humans; D009928:Organ Specificity; D004364:Pharmaceutical Preparations / Q000378:metabolism; D017510:Protein Folding; D013379:Substrate Specificity
chemical_list: D004364:Pharmaceutical Preparations; D004950:Esterases