[Influence of regulatory peptides on the secretion of interleukins from bronchial epithelial cells of the rabbit].
To explore the role of regulatory peptides in the secretion of bronchial epithelial cells (BECs), we observed the effects of four peptides, i.e.vasoactive intestinal peptide (VIP), epidermal growth factor (EGF), endothelin-1 (ET-1), and calcitonin gene-related peptide (CGRP), on the secretion of ILs from unstimulated or O3-stressed BECs. The results of the experiments showed that VIP exerted an inhibitory effect on the secretion of IL-1 and IL-8 from unstimulated and O3-stressed BECs, VIP also decreased the secretion of IL-5 from O3-stressed BECs; EGF promoted secretion of IL-1 and IL-8 from unstimulated BECs, but decreased the secretion of ILs from O3-stressed BECs; ET-1 and CGRP enhanced the secretion of IL-1, IL-5, and IL-8 from unstimlated BECs, CGRP also increased the secretion of ILs from O3-stressed BECs. The results obtained demonstrate that intrapulmonary regulatory peptides modulate the secretion of ILs from BECs, and may play an important part in transduction of inflammatory signals.
Tan
Yu-Rong
YR
Department of Physiology, XiangYa Medical College, Central South University, Changsha 410078.
Qin
Xiao-Qun
XQ
Guan
Cha-Xiang
CX
Zhang
Chang-Qing
CQ
Xiang
Yang
Y
Ren
Yan-Hong
YH
D000818:Animals; D001980:Bronchi / Q000166:cytology; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D002478:Cells, Cultured; D019332:Endothelin-1 / Q000494:pharmacology*; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D007378:Interleukins / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D019332:Endothelin-1; D007378:Interleukins; D014660:Vasoactive Intestinal Peptide; D004815:Epidermal Growth Factor; D015740:Calcitonin Gene-Related Peptide