Relaxation times of choline, creatine and N-acetyl aspartate in human cerebral white matter at 1.5 T.
Several studies have investigated the T1 and T2 relaxation time of choline, creatine and N-acetyl aspartate in cerebral white matter in normal human subjects. However, these studies demonstrate a large variation in T1 and T2 values. In the present study, relaxation times of choline, creatine and N-acetyl aspartate were determined in cerebral white matter in 15 control subjects (age 21 +/- 2 y, mean +/- SD) at 1.5 T. Using PRESS, seven or eight data points were obtained to fit the T1 and T2 relaxation curves to, respectively. The mean voxel size was 14 cm3. The T1 relaxation times of choline, creatine and N-acetyl aspartate were 1091 +/- 132 (mean +/- SD), 1363 +/- 137 and 1276 +/- 132 ms. The T2 relaxation times were 352 +/- 52, 219 +/- 29 and 336 +/- 46 ms, respectively.
Rutgers
D R
DR
Department of Radiology, University Medical Center Utrecht, The Netherlands. D.Rutgers@azu.nl
van der Grond
J
J
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry*; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000378:metabolism*; D002794:Choline / Q000032:analysis / Q000737:chemistry*; D003401:Creatine / Q000032:analysis / Q000737:chemistry; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D012016:Reference Values
D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline