Live and let die: Nef functions beyond HIV replication.
The viral Nef protein is important for the progression of the human and simian immunodeficiency virus (HIV/SIV) infection. So far, experimental evidence has suggested that Nef enhances viral replication and infectivity through a combination of different effects. Recent insights, however, indicate that its functions are more complex than previously anticipated. By targeting the T cell receptor, Nef may not only prime viral replication but, more importantly, ensure viral survival through distinct mechanisms of immune evasion and antiapoptosis.
Fackler
Oliver T
OT
Department of Virology, University of Heidelberg, D-69120 Heidelberg, Germany.
Baur
Andreas S
AS
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D015693:Gene Products, nef / Q000276:immunology*; D006678:HIV / Q000276:immunology* / Q000502:physiology; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology; D014779:Virus Replication / Q000276:immunology*; D054311:nef Gene Products, Human Immunodeficiency Virus
D015693:Gene Products, nef; D011948:Receptors, Antigen, T-Cell; D054311:nef Gene Products, Human Immunodeficiency Virus