title: Studies on the constituents of seeds of Pachyrrhizus erosus and their anti herpes simplex virus (HSV) activities.
abstract: Studies on the chemical constituents of the seeds of Pachyrrhizus erosus (Leguminosae) resulted in the isolation of nine known components: five rotenoids [dolineone (3), pachyrrhizone (5), 12a-hydroxydolineone (7), 12a-hydroxypachyrrhizone (9), and 12a-hydroxyrotenone (2)], two isoflavonoids [neotenone (4) and dehydroneotenone (8)], one phenylfuranocoumarin [pachyrrhizine (6)], and a monosaccharide (dulcitol). The full 1H- and 13C-NMR assignments for the isolated products except a sugar, including revision of previous assignments in the literature, are reported. Moderate anti herpes simplex virus (HSV) activity was observed in 12a-hydroxydolineone (7) and 12a-hydroxypachyrrhizone (9) among the isolated products.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Ampai
authors.initials: A
authors.lastname: Phrutivorapongkul
authors.forename: Vimolmas
authors.initials: V
authors.lastname: Lipipun
authors.forename: Nijsiri
authors.initials: N
authors.lastname: Ruangrungsi
authors.forename: Toshiko
authors.initials: T
authors.lastname: Watanabe
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Ishikawa
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification*; D002522:Chlorocebus aethiops; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D029905:Pachyrhizus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D012639:Seeds / Q000737:chemistry; D013329:Structure-Activity Relationship; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts