title: Metabolic, nutritional, iatrogenic, and artifactual sources of urinary organic acids: a comprehensive table.
abstract: BACKGROUND
  The determination of organic acids and glycine conjugates in urine is key for the diagnosis and follow-up of several inborn errors of metabolism (IEM). However, clinical interpretations may still be hindered by ambiguity in the sources of some urinary organic acids and acylglycines as well as in the relationship between their excretion and IEM.
  
  
  METHODS
  Relevant data have been compiled from major books and references on the topic and by exhaustive bibliographic searches through the Medline and Current Contents databases.
  
  
  BACKGROUND
  A comprehensive table has been designed according to organic acids and conjugates. This table is intended to assist in the interpretation of organic acid profiles because, in addition to IEM, it also refers to other pathologic causes and to physiologic, nutritional, iatrogenic, and artifactual sources. Some preanalytical issues, including possible misinterpretations, are reviewed with regard to IEM.
authors.affiliation: Laboratoire de Biochimie Médicale, Institut de Pharmacie, Université Libre de Bruxelles (ULB), Campus Plaine CP 205/3, Boulevard du Triomphe, B-1050 Brussels, Belgium.
authors.forename: Alain
authors.initials: A
authors.lastname: Kumps
authors.forename: Pierre
authors.initials: P
authors.lastname: Duez
authors.forename: Yves
authors.initials: Y
authors.lastname: Mardens
mesh_terms: D016477:Artifacts; D001800:Blood Specimen Collection; D002264:Carboxylic Acids / Q000652:urine*; D005998:Glycine / Q000378:metabolism; D006801:Humans; D007049:Iatrogenic Disease; D008661:Metabolism, Inborn Errors / Q000175:diagnosis*; D009747:Nutritional Physiological Phenomena
chemical_list: D002264:Carboxylic Acids; D005998:Glycine