A simple nomenclature for a complex proton pump: VHA genes encode the vacuolar H(+)-ATPase.
The vacuolar-type H(+)-ATPase acidifies intracellular compartments and is essential for many processes, including cotransport, guard cell movement, development, and tolerance to environmental stress. We have identified at least 26 genes encoding subunits of the vacuolar-type H(+)-ATPase in the Arabidopsis thaliana genome, although inconsistent nomenclature of these genes is confusing. The pump consists of subunits A through H of the peripheral V(1) complex, and subunits a, c, c" and d of the V(o) membrane sector. Most V(1) subunits are encoded by a single gene, whereas V(o) subunits are encoded by multiple genes found in duplicated segments of the genome. We propose to name these genes VHA-x, where x represents the letter code for each subunit. Applying a consistent nomenclature will help us to understand how the expression, assembly and activity of this pump are integrated with plant growth, signaling, development and adaptation.
Sze
Heven
H
Cell Biology and Molecular Genetics, University of Maryland, HJ Patterson Hall, College Park, MD 20742-5815, USA. hs29@umail.umd.edu
Schumacher
Karin
K
Müller
Mathias L
ML
Padmanaban
Senthilkumar
S
Taiz
Lincoln
L
D000222:Adaptation, Physiological / Q000235:genetics; D017360:Arabidopsis / Q000201:enzymology / Q000235:genetics* / Q000254:growth & development; D002874:Chromosome Mapping; D005810:Multigene Family; D021122:Protein Subunits; D017494:Proton Pumps / Q000235:genetics* / Q000378:metabolism; D009626:Terminology as Topic; D025262:Vacuolar Proton-Translocating ATPases / Q000235:genetics*
D021122:Protein Subunits; D017494:Proton Pumps; D025262:Vacuolar Proton-Translocating ATPases