title: Prevalence of latent autoimmune diabetes of adults (LADA) in Southern Spain.
abstract: OBJECTIVE
  To study the prevalence of diabetes mellitus and islet autoantibodies in an adult population from Southern Spain.
  
  
  METHODS
  A cross-sectional study in Southern Spain of 1226 people, age 18-65 years. Clinical data were obtained and a blood sample taken to measure autoantibodies (glutamic acid decarboxylase antibodies (GADAb), tyrosine phosphatase antibodies (IA2Ab), and insulin antibodies (IAA)). An oral glucose tolerance test (OGTT) was also given to 982 of the subjects.
  
  
  RESULTS
  The overall prevalence of diabetes mellitus according to the WHO 1979 criteria was 10.9% and according to the ADA 1997 criteria it was 14.7% (8.8% were unaware of their diabetes). The prevalence of impaired fasting glucose (IFG) was 12.4% and of impaired glucose tolerance (IGT) 11.5%. The prevalence of GADAb+ in the general population was 0.9% and in the diabetic population 3.7%. There were no significant differences between groups in the prevalence of IA2Ab or IAA (both were 0.8% in the general population). Of the three autoantibodies studied, only GADAb were significantly different in the diabetic population (P=0.0006).
  
  
  CONCLUSIONS
  The prevalence of Type 2 diabetes and LADA are high in the south of Spain.
authors.affiliation: Endocrinology and Nutrition Service, Hospital Civil, Carlos Haya Hospital Complex, Malaga 29018, Spain. soriguer@arrakis.es
authors.forename: Federico
authors.initials: F
authors.lastname: Soriguer-Escofet
authors.forename: Isabel
authors.initials: I
authors.lastname: Esteva
authors.forename: Gemma
authors.initials: G
authors.lastname: Rojo-Martinez
authors.forename: Soledad
authors.initials: S
authors.lastname: Ruiz de Adana
authors.forename: Marieta
authors.initials: M
authors.lastname: Catalá
authors.forename: M José
authors.initials: MJ
authors.lastname: Merelo
authors.forename: Manuel
authors.initials: M
authors.lastname: Aguilar
authors.forename: Francisco
authors.initials: F
authors.lastname: Tinahones
authors.forename: José M
authors.initials: JM
authors.lastname: García-Almeida
authors.forename: Juan M
authors.initials: JM
authors.lastname: Gómez-Zumaquero
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Cuesta-Muñoz
authors.forename: José
authors.initials: J
authors.lastname: Ortego
authors.forename: José M
authors.initials: JM
authors.lastname: Freire
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000276:immunology; D001786:Blood Glucose / Q000378:metabolism; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000276:immunology; D005951:Glucose Tolerance Test; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007330:Insulin Antibodies / Q000097:blood; D008875:Middle Aged; D015995:Prevalence; D017027:Protein Tyrosine Phosphatases / Q000276:immunology; D012016:Reference Values; D015203:Reproducibility of Results; D013030:Spain / Q000453:epidemiology
chemical_list: D001323:Autoantibodies; D001786:Blood Glucose; D007330:Insulin Antibodies; D017027:Protein Tyrosine Phosphatases; D005968:Glutamate Decarboxylase