Oxygen radicals in cardiovascular-renal disease.
Oxidative stress is associated with diabetes mellitus and hypertension. Recent studies suggest that oxygen radicals contribute to the enhanced basal vascular tone, tubuloglomerular feedback, monocyte/macrophage infiltration and sensitivity of the vasculature and to the impaired endothelium-dependent relaxation in the diseased kidney. Pharmacological antioxidants can decrease oxidative stress, improve renal vascular function and decrease blood pressure in cardiovascular-renal disease.
Schnackenberg
Christine G
CG
GlaxoSmithKline, Department of Renal and Urology Research, UW2521, PO Box 1539, King of Prussia, PA 19406, USA. Christine_G_Schackenberg@gsk.com
D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D007674:Kidney Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism*
D017382:Reactive Oxygen Species