Developmental toxicity: web resources for evaluating risk in humans.
This review presents a brief overview of Internet resources that provides information on developmental toxicity. The advantages and limitations of these resources for evaluating human risk and where each one is useful for informing various stages of the risk assessment process (i.e. hazard characterization, dose-response assessment, exposure assessment and risk characterization) are reviewed. How these Internet resources can be utilized to obtain information on and evaluate the developmental risk associated with exposures during pregnancy will be illustrated using toluene. Translating information derived from laboratory and human population studies into clinical management prescriptions for individual patients is difficult. With the increasing availability of Internet resources that provide information relevant for developmental risk assessments, health care professionals will be better equipped to make more accurate estimations of potential risk for their patients.
Polifka
Janine E
JE
Department of Pediatrics, TERIS Project, University of Washington, PO Box 357920, Seattle, WA 98195-7920, USA. polifka@u.washington.edu
Faustman
Elaine M
EM
D000014:Abnormalities, Drug-Induced; D019992:Databases as Topic; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D006801:Humans; D020407:Internet; D018811:Maternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D018570:Risk Assessment; D013723:Teratogens / Q000633:toxicity; D014050:Toluene / Q000633:toxicity
D013723:Teratogens; D014050:Toluene