title: Preparation and in vitro bioactivity of hydroxyapatite/solgel glass biphasic material.
abstract: Hydroxyapatite/solgel glass biphasic material has been obtained in order to improve the bioactivity of the hydroxyapatite (OHAp). A mixture of stoichiometric OHAp and the precursor gel of a solgel glass, with nominal composition in mol% CaO-26, SiO2-70, P205-4, has been prepared. The amounts of components used have been selected to obtain a final relationship for OHAp/solgel glass of 60/40 on heating. Two different thermal treatments have been used: (i) 700 degrees C, temperature of solgel glass stabilisation and (ii) 1000 degrees C, lower temperature of hydroxyapatite sintering. The bioactivity of the resulting materials has been examined in vitro by immersion in simulated body fluid at 37 degrees C. The results obtained show that both materials are bioactive. The apatite-like layer grown is greater for the new materials than for the OHAp and the solgel glass themselves.
authors.affiliation: Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, Spain.
authors.forename: C V
authors.initials: CV
authors.lastname: Ragel
authors.forename: M
authors.initials: M
authors.lastname: Vallet-Regí
authors.forename: L M
authors.initials: LM
authors.lastname: Rodríguez-Lorenzo
mesh_terms: D017610:Calcium Compounds / Q000737:chemistry; D017886:Durapatite / Q000494:pharmacology*; D005782:Gels / Q000737:chemistry*; D005898:Glass / Q000737:chemistry*; D007700:Kinetics; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010087:Oxides / Q000737:chemistry; D017553:Phosphorus Compounds / Q000737:chemistry; D012825:Silicon / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013997:Time Factors
chemical_list: D017610:Calcium Compounds; D005782:Gels; D010087:Oxides; D017553:Phosphorus Compounds; C012500:phosphorus pentoxide; D012822:Silicon Dioxide; D017886:Durapatite; C016538:lime; D012825:Silicon