title: [A clinicopathological study of demyelination pseudotumors of the brain].
abstract: OBJECTIVE
  To study the clinicopathological characteristics diagnosis, differential diagnosis and etiology of demyelination pseudotumors of the brain.
  
  
  METHODS
  The clinical features, CT, MRI scan findings, corticosteroid therapeutic effects and follow-up data of 3 cases of demyelination pseudotumors of the brain were analysed, and pathological changes were observed by histologic (HE, Luxol fast blue and Bodian) and immunohistochemical (S-P method) techniques.
  
  
  RESULTS
  The acute onset of demyelination pseudotumors appeared to be more predominant in our data. Clinical manifestations included headache, vomiting, a depressed conscious level, dysphasia, and paresis. CT, MRI scans showed solitary or multiple lesions in cerebral hemisphere. All the patients presented excellent response to steroid treatment. Follow-up for a period of 6 to 31 months, revealed the absence of progression or recurrence. The pathological changes were mainly located in both cerebral hemispheres, in which there were relative axonal preservation in foci loss of myelin, reactive gliosis, profuse perivascular lymphocytic infiltration and mixtures of foamy macrophages.
  
  
  CONCLUSIONS
  Demyelination pseudotumor is a distinct clinicopathologic encephalitic entity. The findings of this study suggest that the cause of tumefactive demyelination may be related to an allergic reaction triggered by viral infection.
authors.affiliation: Department of Pathology, Beijing Hospital, Beijing 100730, China (Email: liudongge@263.net)
authors.forename: Dongge
authors.initials: D
authors.lastname: Liu
authors.forename: Chongqing
authors.initials: C
authors.lastname: Yang
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Liu
authors.forename: Kui
authors.initials: K
authors.lastname: Cai
authors.forename: Di
authors.initials: D
authors.lastname: Cui
authors.forename: Kaiquan
authors.initials: K
authors.lastname: Man
mesh_terms: D000293:Adolescent; D000328:Adult; D003711:Demyelinating Diseases / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011559:Pseudotumor Cerebri / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed / Q000379:methods