Trimethylsilylethynyl ketones as surrogates for ethynyl ketones in the double Michael reaction.
Trimethylsilylethynyl ketones can be desilylated in the presence of a tethered carbon diacid and induced to undergo a double Michael reaction in situ. The trimethylsilylethynyl ketones can serve as surrogates of ethynyl ketones that are difficult to prepare or isolate.
Holeman
Derrick S
DS
Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506-0055, USA.
Rasne
Ravindra M
RM
Grossman
Robert B
RB
D000473:Alkanes / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012821:Silanes / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
D000473:Alkanes; D007659:Ketones; D012821:Silanes