title: Sulphonamide residues in eggs following drug administration via the drinking water.
abstract: The aim was to determine concentrations of sulphadimidine (SDM) and sulphadimethoxine (SDT) in eggs following oral administration through drinking water for 5 days (0.5 g l(-1) for SDT, 1 and 2 g l(-1) for SDM). Residues of sulphonamides in albumen and yolk were monitored by high-performance liquid chromatography with UV detection. The limit of quantification was 0.005 microg g(-1) for the two egg components. The results indicate that 0.9-1.4% of the dose administered was deposited in eggs. Maximum concentrations in albumen were much higher than those in yolk. More than 75% of the overall sulphonamides detected in eggs was concentrated in the albumen. The residue levels declined below the limit of quantification within 12-20 days for albumen and 14-15 days for yolk after treatment was discontinued.
authors.affiliation: Afssa, Laboratoire des Medicaments Veterinaires, Fougeres, France. b.roudaut@fougeres.afssa.fr
authors.forename: B
authors.initials: B
authors.lastname: Roudaut
authors.forename: M
authors.initials: M
authors.lastname: Garnier
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002645:Chickens / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004350:Drug Residues / Q000493:pharmacokinetics*; D004529:Egg White / Q000032:analysis; D004530:Egg Yolk / Q000378:metabolism; D004531:Eggs / Q000032:analysis*; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D013412:Sulfadimethoxine / Q000008:administration & dosage / Q000493:pharmacokinetics; D013418:Sulfamethazine / Q000008:administration & dosage / Q000493:pharmacokinetics; D013449:Sulfonamides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014867:Water
chemical_list: D000890:Anti-Infective Agents; D013449:Sulfonamides; D014867:Water; D013412:Sulfadimethoxine; D013418:Sulfamethazine