title: Is high-sensitivity C-reactive protein an effective screening test for cardiovascular risk?
abstract: We evaluate the suggestion that high-sensitivity C-reactive protein testing be used for risk assessment in the primary prevention of cardiovascular disease, using the criteria proposed by the Guide to Clinical Preventive Services developed by the US Preventive Services Task Force. We conclude that at present, none of the 3 major criteria--accuracy, reliability, and likelihood of beneficial intervention--are satisfied.
authors.affiliation: Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA. Ikushner@metrohealth.org
authors.forename: Irving
authors.initials: I
authors.lastname: Kushner
authors.forename: Ashwini R
authors.initials: AR
authors.lastname: Sehgal
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control*; D006801:Humans; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity
chemical_list: D002097:C-Reactive Protein