Colchicine effect in a colonic hyperplastic polyp. A lesion mimicking serrated adenoma.
Colchicine effect has been described recently in gastrointestinal biopsies, where it can result in accumulation of metaphase mitoses and epithelial disorganization. We describe the case of a colonic hyperplastic polyp with colchicine effect from a 52-year-old woman who was receiving colchicine for primary biliary cirrhosis. Biopsy of the polyp revealed prominent metaphase mitoses and focal loss of nuclear polarity in the surface epithelium, features that mimicked a serrated adenoma. Distinguishing between hyperplastic polyp and serrated adenoma is important because of the different management implications and the increased potential for neoplastic progression in the latter.
Torbenson
Michael
M
Division of Gastrointestinal/Liver Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA.
Montgomery
Elizabeth A
EA
Iacobuzio-Donahue
Christine
C
Yardley
John H
JH
Wu
Tsung-Teh
TT
Abraham
Susan C
SC
D000236:Adenoma / Q000473:pathology*; D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor / Q000032:analysis; D016764:Cell Polarity / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000737:chemistry / Q000473:pathology*; D003111:Colonic Polyps / Q000737:chemistry / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008875:Middle Aged; D008938:Mitosis / Q000187:drug effects; D009687:Nuclear Proteins / Q000032:analysis
D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D003078:Colchicine