title: Continuous monitoring of cerebrovascular autoregulation: a validation study.
abstract: BACKGROUND
  Continuous monitoring of dynamic cerebral autoregulation, using a moving correlation index of cerebral perfusion pressure and mean middle cerebral artery flow velocity, may be useful in patients with severe traumatic brain injury to guide treatment, and has been shown to be of prognostic value.
  
  
  OBJECTIVE
  To compare an index of dynamic cerebral autoregulation (Mx) with an index of static cerebral autoregulation (sRoR).
  
  
  METHODS
  Mx was validated in a prospective comparative study against sRoR, using 83 testing sessions in 17 patients with traumatic brain injury. sRoR and Mx were calculated simultaneously during pharmacologically induced blood pressure variations.
  
  
  RESULTS
  Mx was significantly correlated with sRoR (R = -0.78, p < 0.05). Nine patients were found to have failure of cerebral autoregulation, with an sRoR value < 50%. If an Mx value of 0.3 was used as the cut off point for failure of cerebral autoregulation, this index had 100% sensitivity and 90% specificity for demonstrating failure of autoregulation compared with the sRoR. An increase in cerebral blood flow velocity correlated significantly with Mx (R = 0.73, p < 0.05) but not with cerebral perfusion pressure (R = 0.41).
  
  
  CONCLUSIONS
  Dynamic and static cerebral autoregulation are significantly correlated in traumatic brain injury. Cerebral autoregulation can be monitored continuously, graded, and reliably assessed using a moving correlation analysis of cerebral perfusion pressure and cerebral blood flow velocity (Mx). The Mx index can be used to monitor cerebral blood flow regulation. It is useful in traumatic brain injury because it does not require any external stimulus.
authors.affiliation: Department of Neurosurgery, Christian-Albrechts-Universität, Weimarer Strasse 8, D-24106 Kiel, Germany. keeflang@optusnet.com.au
authors.forename: E W
authors.initials: EW
authors.lastname: Lang
authors.forename: H M
authors.initials: HM
authors.lastname: Mehdorn
authors.forename: N W C
authors.initials: NW
authors.lastname: Dorsch
authors.forename: M
authors.initials: M
authors.lastname: Czosnyka
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001794:Blood Pressure; D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000098:blood supply* / Q000473:pathology; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012039:Regional Blood Flow; D012680:Sensitivity and Specificity