title: Effect of deep hypothermia on cerebral hemodynamics during selective cerebral perfusion with systemic circulatory arrest.
abstract: OBJECTIVE
  We studied the effect of deep hypothermia on cerebral hemodynamics during selective cerebral perfusion with systemic circulatory arrest.
  
  
  METHODS
  Ten anesthesized pigs were placed on cardiopulmonary bypass and cooled to a rectal temperature of 22 degrees C (n = 5) or 15 degrees C (n = 5). During selective cerebral perfusion, the descending aorta was clamped and perfusion of the lower body was discontinued. As the pump flow was changed, we monitored the perfusion pressure, local cerebral blood flow, and local cerebral oxygenation using laser Doppler flowmetry and near-infrared spectroscopy. We also measured the free flow of the left internal thoracic artery during selective cerebral perfusion.
  
  
  RESULTS
  Perfusion pressure and local cerebral blood flow decreased as the pump flow decreased. Oxygenated and deoxygenated hemoglobin in cerebral tissue remained unchanged at a perfusion flow of 10 ml/kg/min, whereas oxygenated hemoglobin decreased and deoxygenated hemoglobin increased progressively and reciprocally as the pump flow decreased. The pump flow for maintaining perfusion pressure above 35 mmHg with stabilized local cerebral oxygenation was significantly higher at 15 degrees C than at 22 degrees C. The internal thoracic artery free flow was higher at 15 degrees C than at 22 degrees C.
  
  
  CONCLUSIONS
  Selective hypothermic cerebral perfusion with systemic circulatory arrest produces an extracranial shunt through the internal thoracic artery, especially under deep hypothermia. Our data suggests that selective cerebral perfusion during deep hypothermia is best managed by perfusion pressure control rather than by flow control.
authors.affiliation: Division of Cardiovascular Surgery, Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Ito
mesh_terms: D000818:Animals; D002315:Cardiopulmonary Bypass; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006324:Heart Arrest, Induced; D006454:Hemoglobins / Q000032:analysis; D007036:Hypothermia, Induced; D017078:Laser-Doppler Flowmetry; D019265:Spectroscopy, Near-Infrared; D013552:Swine
chemical_list: D006454:Hemoglobins