title: Application of Rh(I)-catalyzed C-H bond activation to the ring opening of 2-cycloalkenones in the presence of amines.
abstract: [reaction: see text]. Herein described is the application of the Rh(I)-catalyzed C-H bond activation to the ring-opening of 2-cycloalkenones in the presence of cyclohexylamine. This reaction includes the C-C double bond cleavage of 2-cycloalkenones through the conjugate addition of cyclohexylamine followed by the retro-Mannich-type fragmentation. The resulting ring-opened intermediates subsequently underwent either chelation-assisted hydroacylation to afford a ring-opened dicarbonyl compound or beta-alkylation via a ring contraction.
authors.affiliation: Department of Chemistry, Yonsei University, Seoul 120-749, Korea. junch@yonsei.ac.kr
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Jun
authors.forename: Choong Woon
authors.initials: CW
authors.lastname: Moon
authors.forename: Sung-Gon
authors.initials: SG
authors.lastname: Lim
authors.forename: Hyuk
authors.initials: H
authors.lastname: Lee