title: Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder.
abstract: Recent data from several reports indicate that free radicals are involved in aetiopathogenesis of many human pathologies including neuropsychiatric disorders such as schizophrenia, bipolar disorder etc. In the present study, we aimed at determining and evaluating levels of malondialdehyde (MDA), a product of lipid peroxidation, and antioxidant enzyme superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity levels in patients diagnosed with schizophrenia (n = 25) and bipolar disorder (n = 23). The control group was composed of 20 healthy subjects. There was a significant increase in MDA levels of patients with schizophrenia and bipolar disorder compared with controls. SOD and GSH-Px activity levels were significantly higher in the schizophrenic group compared with controls. SOD activity levels in bipolar the group were significantly higher than controls whereas there were no significant changes in GSH-Px activity levels in the bipolar group and controls. Significant differences between lipid peroxidation product and antioxidant enzyme (SOD and GSH-Px) activity levels in schizophrenic and bipolar disorder patients compared with controls leads us to believe that these differences are related to the heterogenities in aetiologies of these disorders.
authors.affiliation: Department of Psychiatry, College of Medicine and Firat Medical Center, Firat (Euphrates) University, Elazig, Turkey. kuloglum@yahoo.com
authors.forename: Murat
authors.initials: M
authors.lastname: Kuloglu
authors.forename: Bilal
authors.initials: B
authors.lastname: Ustundag
authors.forename: Murad
authors.initials: M
authors.lastname: Atmaca
authors.forename: Halit
authors.initials: H
authors.lastname: Canatan
authors.forename: A Ertan
authors.initials: AE
authors.lastname: Tezcan
authors.forename: Nadire
authors.initials: N
authors.lastname: Cinkilinc
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D001714:Bipolar Disorder / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase