The ectopic expression of gastric mucin in extramammary and mammary Paget's disease.
The immunohistochemical analysis of the ectopic expression of gastric mucin has been used as a valuable tool for the identification of several neoplasms. We performed an immunohistochemical examination of the expression of gastric, intestinal, and mammary-type mucins in 25 lesions from patients with extramammary Paget's disease (ExMPD) and in 10 lesions from patients with mammary Paget's disease (MPD). All ExMPD lesions were immunopositive for HGM-45, a marker of gastric surface mucous cells, whereas only 40% of MPD lesions were weakly immunopositive. No markers for gastric-gland mucous cells were found in almost all ExMPD and MPD lesions, and markers for intestinal mucin were recognized in only a few lesions. Antibodies specific for MUC1, a marker of mammary-type mucin, gave positive results in both ExMPD and MPD lesions at a higher frequency than antibodies specific for gross cystic disease fluid protein-15. Our analysis indicates that Paget's cells contain gastric surface-type mucin in ExMPD and they contain mammary-type mucin in both ExMPD and MPD. The ectopic localization of mucosubstances may be a further step in the understanding of these lesions. Moreover, antibodies against MUC1 seem to be a useful tool for the diagnosis of both ExMPD and MPD.
Kondo
Yoshiyuki
Y
Department of Pathology, Oita Medical University, Oita, Japan. kondoy@oita-med.ac.jp
Kashima
Kenji
K
Daa
Tsutomu
T
Fujiwara
Sakuhei
S
Nakayama
Iwao
I
Yokoyama
Shigeo
S
D000368:Aged; D000369:Aged, 80 and over; D001053:Apolipoproteins; D053399:Apolipoproteins D; D015415:Biomarkers / Q000032:analysis; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002352:Carrier Proteins / Q000032:analysis; D005260:Female; D005752:Gastric Mucins / Q000378:metabolism*; D006023:Glycoproteins; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D026901:Membrane Transport Proteins; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D010145:Paget Disease, Extramammary / Q000378:metabolism* / Q000473:pathology; D010144:Paget's Disease, Mammary / Q000378:metabolism* / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology
C024328:APOD protein, human; D001053:Apolipoproteins; D053399:Apolipoproteins D; D015415:Biomarkers; D002352:Carrier Proteins; D005752:Gastric Mucins; D006023:Glycoproteins; D026901:Membrane Transport Proteins; D018396:Mucin-1; C488892:PIP protein, human