title: Induction of apoptosis by aryl-substituted diamines: role of aromatic group substituents and distance between nitrogens.
abstract: A series of aromatic substituted diamines was synthesized and characterized for their cytotoxic profiles against human breast and prostate tumor cell lines. Following a structure function analysis of the effects of changes of the benzyl substituents and the distance between amino groups the most potent analogues were analyzed biologically and were shown to induce apoptosis. These compounds do not induce the enzyme SSAT or deplete intracellular polyamine levels, mechanisms demonstrated by other cytotoxic polyamine analogues.
authors.affiliation: MediQuest Therapeutics, Inc., 4010 Stone Way North, Seattle, WA 98103, USA. markburns@mqti.com
authors.forename: Mark R
authors.initials: MR
authors.lastname: Burns
authors.forename: Solveig
authors.initials: S
authors.lastname: LaTurner
authors.forename: Josh
authors.initials: J
authors.lastname: Ziemer
authors.forename: Maralee
authors.initials: M
authors.lastname: McVean
authors.forename: Bruce
authors.initials: B
authors.lastname: Devens
authors.forename: C Lance
authors.initials: CL
authors.lastname: Carlson
authors.forename: Gerard F
authors.initials: GF
authors.lastname: Graminski
authors.forename: Scott M
authors.initials: SM
authors.lastname: Vanderwerf
authors.forename: Reitha S
authors.initials: RS
authors.lastname: Weeks
authors.forename: Jay
authors.initials: J
authors.lastname: Carreon
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D003959:Diamines / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009584:Nitrogen / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D003959:Diamines; D009584:Nitrogen