Beneficial effects of tandospirone on ataxia of a patient with Machado-Joseph disease.
Tandospirone citrate (tandospirone) is an anti-anxiety drug that acts by combining with serotonin receptor (5-hydroxytryptamine-1 A [5-HT1A]). Recently, there have been a few reports of its potential role in the treatment of cerebellar ataxia. We report the first case of a patient with Machado-Joseph disease in which we successfully treated cerebellar ataxia. In addition, his leg pain, insomnia, anorexia, and depression, which are thought to be related to 5-HT1A receptors, were also remarkably alleviated by treatment with tandospirone.
Takei
Asako
A
Hokuyukai Neurology Hospital, Sapporo, Japan. atakei@med.hokudai.ac.jp
Honma
Sanae
S
Kawashima
Atushi
A
Yabe
Ichiro
I
Fukazawa
Toshiyuki
T
Hamada
Keiko
K
Hamada
Takeshi
T
Tashiro
Kunio
K
D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002524:Cerebellar Ataxia / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D054833:Isoindoles; D017827:Machado-Joseph Disease / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D044263:Receptors, Serotonin, 5-HT1; D016896:Treatment Outcome
D014151:Anti-Anxiety Agents; D054833:Isoindoles; D010879:Piperazines; D011743:Pyrimidines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; C055267:tandospirone