Cytopathology of explanted intraocular lenses and the clinical correlation.
OBJECTIVE
To study the cytopathological features of explanted intraocular lenses (IOLs) and correlate the features with their clinical presentation.


METHODS
Ocular Pathology Department, Medical and Vision Research Foundation, Sankara Nethralaya, Chennai, India.


METHODS
The study comprised 61 explanted IOLs (48 posterior chamber IOLs and 13 anterior chamber IOLs) removed for the following reasons: pseudophakic bullous keratopathy (36), recalcitrant uveitis (7), retinal detachment (10), endophthalmitis (5), uveitis (7), IOL subluxation (2), and painful blind eye (1). The IOLs were stained with hematoxylin and eosin using a simple cytological technique. The cytopathological features were studied and correlated with the clinical presentations.


RESULTS
The mean time of IOL explantation was 10.1 months after surgery. Twenty-one IOLs had granulomatous and nongranulomatous inflammations and 4, nongranulomatous inflammations. One IOL had fungal filaments on the surface.


CONCLUSIONS
Intraocular lenses can produce both granulomatous and nongranulomatous inflammation. Granulomatous inflammation was the most common in this series. The surface of IOLs explanted because of intraocular infection may show infective agents.
Biswas
Jyotirmay
J
Medical and Vision Research Foundation, Chennai, India. mrf@sankaranethralaya.org
Kumar
S Krishna
SK
D020878:Device Removal; D005129:Eye Foreign Bodies / Q000473:pathology* / Q000601:surgery; D015745:Granuloma, Foreign-Body / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007910:Lenses, Intraocular; D013997:Time Factors