title: Preliminary study on antifertility activity of Calotropis procera roots in female rats.
abstract: The effect of ethanolic extract of the roots of Calotropis procera has been studied in albino rats to explore its antifertility and hormonal activities. A strong antiimplantation (inhibition 100%) and uterotropic activity was observed at the dose level of 250 mg/kg (1/4 of LD(50)). No antiestrogenic activity could be detected.
authors.affiliation: Department of Pharmacology, Krupanidhi College of Pharmacy, Sarjapur Road, Kormanagala, Bangalore 560 034, India. jvkam@rediffmail.com
authors.forename: Jagadish V
authors.initials: JV
authors.lastname: Kamath
authors.forename: A C
authors.initials: AC
authors.lastname: Rana
mesh_terms: D000284:Administration, Oral; D000818:Animals; D029062:Apocynaceae; D002584:Cervix Uteri / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018517:Plant Roots; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000187:drug effects* / Q000502:physiology; D014621:Vagina / Q000187:drug effects / Q000502:physiology
chemical_list: D010936:Plant Extracts