[Expression of a novel immunoglobulin gene SNC73 in human cancer and its significance].
OBJECTIVE
To investigate the expression of a new immunoglobulin gene SNC73 in malignant tumor and normal tissue and its significance.


METHODS
Expression level of SNC73 in tumors and normal tissues was determined by reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay (RT-PCR-ELISA) in 90 malignant tumors, including colorectal cancer, gastric cancer, breast cancer, lung cancer and liver cancer. Analysis on relation of SNC73 expression with age, sex, site, differentiation grade, depth of invasion and metastasis of colorectal cancer was made to assess the clinical significance of SNC73.


RESULTS
Mean ratio of SNC73 expression level in normal mucosa and colorectal cancer tissue was 7.134 (P < 0.01). Expression of SNC73 showed no significant difference among gastric cancer, breast cancer, lung cancer or liver cancer as compared with the control normal tissues (P > 0.05).


CONCLUSIONS
Down-regulation of SNC73 expression is a relatively specific phenomenon in colorectal cancer for which development SNC73 may be a potential genetic marker. The study on relationship of SNC73 expression with development of colorectal cancer is promising.
Hu
Jianbin
J
Cancer Institute, Zhejiang University, Hangzhou 310009, China.
Deng
Yongchuan
Y
Zheng
Shu
S
D015179:Colorectal Neoplasms / Q000235:genetics*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015870:Gene Expression; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*
D007136:Immunoglobulins; D011506:Proteins; C452824:IGHA1 protein, human