[Study of XW630 in promoting estrogen receptor expression in ovariectomized rats].
We adopted firstly the dextran-coated charcoal(DCC) and SP methods to detect estrogen receptor (ER) expression of bone tissue in ovariectomized(OVX) rats. The results demonstrate that in OVX rats, XW630 can significantly promote ER expression in bone tissue and increase the ER content. XW630 is superior to estrone in effectiveness. The results also reveal that the ER expression in OVX rat bone tissue decreases with the lapse of time, indicating that the expression of ER depends on the existence of estrogen.
Fei
Wei
W
Department of Oral and Maxillofacial Surgery, Sichuan Provincial People's Hospital, Chengdu 610072.
Wang
Dazhang
D
Zheng
Hu
H
Weng
Lingling
L
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology*; D005260:Female; D010052:Ovariectomy; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000096:biosynthesis*; D013752:Tetracycline / Q000494:pharmacology*; D013754:Tetracyclines
C428143:2-(3-estrone-N-ethyl-piperazine-methyl)tetracycline; D004966:Estrogens, Conjugated (USP); D010879:Piperazines; D011960:Receptors, Estrogen; D013754:Tetracyclines; D013752:Tetracycline