title: Fluoride concentrations in saliva and dental plaque in young children after intake of fluoridated milk.
abstract: This study determined fluoride (F) concentrations in whole saliva and dental plaque after intake of fluoridated milk using a randomised crossover experimental design. Eighteen healthy children (6-8 years) were subjected to each of four different 3-day drinking regimens: (a) 200 ml F-free tap water; (b) 200 ml tap water with 1.0 mg F; (c) 200 ml standard milk, and (d) 200 ml standard milk with 1.0 mg F. A washout period of 7 days was organised between the different drinking regimens. All children used F-free toothpaste prior to and during the trial and were instructed to avoid F-rich food and drinks. F concentration in unstimulated whole saliva was determined at baseline and after 15 and 120 min and in plaque samples at baseline and after 2 h. The mean baseline values ranged from 0.01 to 0.02 mg F/l in saliva and between 10.4 and 14.2 mg F/l in dental plaque. A statistically significant (p < 0.05) increase of F was disclosed in saliva 15 min after drinking F-containing milk and water (0.052 and 0.058 mg F/l, respectively). After 2 h, the salivary F(-) concentrations were back to baseline values. In the plaque, however, a statistically significant (p < 0.01) twofold increase was found at 2 h after the intake of fluoridated milk and water, respectively. The results indicate that consumption of fluoridated milk contributes to a F storing process with significantly elevated F concentrations in dental plaque up to 2 h after intake. Further studies are required to determine the 'therapeutic concentration' of F in dental plaque after intake of fluoridated milk.
authors.affiliation: Medical and Oral Health Centre, Halmstad, Sweden. lars.g.petersson@lthalland.se
authors.forename: L G
authors.initials: LG
authors.lastname: Petersson
authors.forename: I
authors.initials: I
authors.lastname: Arvidsson
authors.forename: E
authors.initials: E
authors.lastname: Lynch
authors.forename: K
authors.initials: K
authors.lastname: Engström
authors.forename: S
authors.initials: S
authors.lastname: Twetman
mesh_terms: D000818:Animals; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000032:analysis* / Q000627:therapeutic use; D002648:Child; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000737:chemistry*; D004326:Drinking; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis* / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D017736:Ion-Selective Electrodes; D008297:Male; D008892:Milk; D012463:Saliva / Q000737:chemistry*; D013223:Statistics as Topic; D014100:Toothpastes / Q000627:therapeutic use; D014867:Water
chemical_list: D002327:Cariostatic Agents; D014100:Toothpastes; D014867:Water; D005459:Fluorides