Gold nanoparticles as novel label for DNA diagnostics.
The growing interest in DNA diagnostics, especially in combination with the need for highly-paralleled and miniaturized hybridization assays, is today addressed by fluorescence DNA chips. Fluorescence detection is approved and highly developed, however, it has also problematic aspects, e.g., the low stability of the dyes, the influence of the physicochemical environment onto the signal intensity and the expensive set-up for detection. A novel detection scheme based on metal nanoparticles was proposed to overcome these problems and is discussed in this review.
Csáki
Andrea
A
Molecular Nanotechnology Group, Institute for Physical High Technology, PO Box 100239, 07702 Jena, Germany.
Möller
Robert
R
Fritzsche
Wolfgang
W
D004247:DNA / Q000032:analysis*; D015342:DNA Probes / Q000032:analysis; D005898:Glass; D017979:Gold Colloid / Q000737:chemistry; D006801:Humans; D008904:Miniaturization; D036103:Nanotechnology; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D010316:Particle Size
D015342:DNA Probes; D017979:Gold Colloid; D004247:DNA