Long-term follow-up of a patient with cutaneous vasculitis secondary to mixed cryoglobulinaemia and hepatitis C virus.
We describe the clinical course of a patient with mixed cryoglobulinaemia and multisystem disease over a 21-year period. She consistently tested negative for hepatitis C virus (HCV) serology, but active HCV infection (genotype Ia) was confirmed using reverse transcription-polymerase chain reaction. After initial improvement following treatment with interferon-alpha and ribavirin, unfortunately she developed severe neutropenia necessitating discontinuation of both drugs within 4 weeks. She died 1 month later.
Kapur
N
N
Department of Dermatology and Histopathology, The Middlesex and University College Hospitals, London, UK. natashakapur3@hotmail.com
Tympanidis
P
P
Colville
C
C
Yu
R C
RC
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003449:Cryoglobulinemia / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D017445:Skin Diseases, Vascular / Q000209:etiology* / Q000473:pathology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000209:etiology*
D000998:Antiviral Agents