[A patient who developed dermatomyositis during the 1st trimester of gestation and improved after abortion].
This patient was a 30-year-old woman who was in the 8th week of her first pregnancy with three embryos. She developed fever, myalgia and weakness of the proximal muscles, and erythema of the face, dorsal aspects of elbows, and knees. Routine blood examinations showed elevated serum CK. Immunologically, an anti-Jo-1 antibody was positive. Skin biopsy revealed mucinosis and edema in the superficial layer of the corium, and liquid alternation in the basal layer of the epidermis. From these findings, this patient was diagnosed as having dermatomyositis. She was placed on oral prednisolone (80 mg daily), but her clinical symptoms did not improve and all fetuses died by the 11th week of gestation. Then she underwent dilation and curettage and after this operation her disease rapidly subsided. It seemed that fetuses were causatively related to the development of dermatomyositis possibly by changing maternal immune condition. There were six reported cases with dermatomyositis/polymyositis who developed during the first trimester of gestation. Four of these 6 patients were treated with oral steroid; however, only one patient ended in normal delivery. More aggressive therapy, other than corticosteroid, may be required to improve fetal prognosis.
Tojyo
K
K
Third Department of Medicine, Shinshu University School of Medicine.
Sekijima
Y
Y
Hattori
T
T
Tsuyuzaki
J
J
Nakamura
A
A
Kita
N
N
Ikeda
S
S
D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D003882:Dermatomyositis / Q000209:etiology*; D005260:Female; D005313:Fetal Death; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D011261:Pregnancy Trimester, First