Social disruption-induced glucocorticoid resistance: kinetics and site specificity.
Social disruption (SDR) of male mice has been shown to induce a state of functional glucocorticoid (GC) resistance in splenocytes. The present study demonstrated that GC resistance developed following repeated, but not acute exposure to SDR. GC resistance was long-lasting and persisted for at least 10 days after stress. In contrast, SDR did not alter cytokine secretion from peritoneal mononuclear cells treated with corticosterone. These findings suggest that SDR-induced GC resistance may be restricted to specific sites such as the spleen.
Avitsur
Ronit
R
Section of Oral Biology, The Ohio State University Health Sciences Center, Columbus, OH 43218, USA.
Stark
Jennifer L
JL
Dhabhar
Firdaus S
FS
Padgett
David A
DA
Sheridan
John F
JF
D000818:Animals; D002478:Cells, Cultured; D003345:Corticosterone / Q000493:pharmacokinetics / Q000494:pharmacology*; D004351:Drug Resistance; D007398:Interpersonal Relations; D007700:Kinetics; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000503:physiopathology*; D013315:Stress, Psychological / Q000209:etiology* / Q000503:physiopathology*
D003345:Corticosterone