title: Gestational trophoblastic disease: one more risk in adolescent pregnancy.
abstract: BACKGROUND
  An evaluation of the performance of a Referral Center in the diagnosis, treatment and follow up of adolescents with gestational trophoblastic disease.
  
  
  METHODS
  In a 13-year prospective cohort study, between March 1987 and March 2000, 124 adolescents with gestational trophoblastic disease were followed up and/or treated by a multidisciplinary team. Adolescents underwent strict clinical and laboratory control after mole evacuation to guarantee adhesion to follow up, early diagnosis, and prompt treatment of persistent disease. The Student-Fischer t-test and the chi-square test were used for the statistic analysis of the results.
  
  
  RESULTS
  Adolescents represented 21.3% of the 583 patients with gestational trophoblastic disease: 102 (82.3%) had uncomplicated hydatidiform moles, and 22 (17.7%) underwent chemotherapy for persistent gestational trophoblastic disease or a gestational trophoblastic tumor. Complications were diagnosed earlier (p < 0.001) in patients managed and treated at the referral center. Of the adolescents with complications, 81.8% were low risk, 54.5% were at the International Federation of Gynecology and Obstetrics stage I, and 90.9% were treated with chemotherapy only. Time to remission and follow up were shorter for uncomplicated hydatidiform moles (9.8 +/- 3.4 weeks and 8.8 +/- 1.8 months, respectively) than for persistent disease (16.2 +/- 5.8 weeks and 45 +/- 24.5 months, respectively). Adhesion to follow up was similar in the two groups (84.2% and 91.8%). To this date, 50% of the adolescents have had one or more gestations, and 82% of these pregnancies were normal.
  
  
  CONCLUSIONS
  Adolescents comprise approximately 20% of all gestational trophoblastic disease patients and have high adhesion to follow up. The disease did not affect their reproductive capacity, and chances of a normal subsequent gestation were high.
authors.affiliation: Centro de Doenças Trofoblásticas, Mário Totta Maternity Ward, Hospital Irmandade da Santa Casa de Misericórdia de Porto Alegre, RS, Brazil. elzauberti@cpovo.net
authors.forename: Elza M H
authors.initials: EM
authors.lastname: Uberti
authors.forename: Maria Do Carmo F
authors.initials: Mdo C
authors.lastname: Diestel
authors.forename: Fernando E
authors.initials: FE
authors.lastname: Guimarães
authors.forename: Tatiana
authors.initials: T
authors.lastname: Goloubkova
authors.forename: Marcos W
authors.initials: MW
authors.lastname: Rosa
authors.forename: Gilberto
authors.initials: G
authors.lastname: De Nápoli
mesh_terms: D000293:Adolescent; D015331:Cohort Studies; D005260:Female; D006801:Humans; D011247:Pregnancy; D011253:Pregnancy in Adolescence; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D014328:Trophoblastic Neoplasms / Q000453:epidemiology*; D014594:Uterine Neoplasms / Q000453:epidemiology*