Quantitative functional measures in MS: what is a reliable change?
As a first step toward understanding which changes should be considered as meaningful, the authors assessed the reliability of quantitative functional tests on 5 consecutive days in 63 patients with MS, determining the range of measurement variability present when patients are clinically stable. Time to walk 25 feet (T25FW) and the 9-hole peg test (9HPT) varied by <20% of individual mean scores on repeated testing. Therefore, a 20% change on these tests can be considered to be the threshold that reliably indicates a true change in function for an individual.
Schwid
S R
SR
Department of Neurology, University of Rochester Medical Center, NY, USA. Steven_Schwid@urmc.rochester.edu
Goodman
A D
AD
McDermott
M P
MP
Bever
C F
CF
Cook
S D
SD
D000328:Adult; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000503:physiopathology*; D009460:Neurologic Examination; D011597:Psychomotor Performance / Q000502:physiology; D015203:Reproducibility of Results; D016138:Walking / Q000502:physiology