title: Autologous thrombin: a new embolization treatment for traumatic intrasplenic pseudoaneurysm.
abstract: OBJECTIVE
  To report the use of autologous thrombin for transcatheter embolization of a traumatic parenchymal splenic pseudoaneurysm.
  
  
  METHODS
  A 15-year-old boy presented with a splenic parenchymal laceration after blunt abdominal trauma. The patient was managed conservatively but developed an intrasplenic pseudoaneurysm (grade III AAST scale) with subcapsular contrast extravasation after 3 weeks. Autologous thrombin was isolated from the patient's blood and subsequently delivered to the lesion by transcatheter superselective injection into the aneurysm neck. The patient was asymptomatic after the procedure. Nine months' follow-up demonstrated a normal spleen with completely homogenous parenchyma.
  
  
  CONCLUSIONS
  Autologous thrombin injection to induce thrombosis of intrasplenic pseudoaneurysm represents a new treatment option for traumatic abdominal organ injuries. Intrasac thrombosis can be safely induced to successfully restore the splenic parenchymal integrity without introduction of foreign material and associated risks of adverse reactions or infection that might accompany the use of commercial thrombin preparations.
authors.affiliation: Department of Radiology, St. George's Hospital, London, England, UK. cengelke@hotmail.com
authors.forename: Christoph
authors.initials: C
authors.lastname: Engelke
authors.forename: John
authors.initials: J
authors.lastname: Quarmby
authors.forename: Gaurang
authors.initials: G
authors.lastname: Ubhayakar
authors.forename: Robert
authors.initials: R
authors.lastname: Morgan
authors.forename: Keith
authors.initials: K
authors.lastname: Holmes
authors.forename: Anna-Maria
authors.initials: AM
authors.lastname: Belli
mesh_terms: D000293:Adolescent; D017541:Aneurysm, False / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D000792:Angiography; D004621:Embolization, Therapeutic / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D013154:Spleen / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000293:injuries*; D013917:Thrombin / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014949:Wounds, Nonpenetrating / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy
chemical_list: D013917:Thrombin