[Crystallochemistry of copper (II) and zinc (II) chelates by nonsteroidal antiinflammatory drugs].
Copper(II) and zinc(II) chelates by some non-steroidal antiinflammatory drugs NSAIDs (niflumic acid, indomethacin) and 3,5-diisopropylsalicylic acid (DIPS) were characterized by single X-ray diffraction methods. Copper(II) complexes by these two types of chelates are binuclear compounds, with Cu(2)(DIPS)(4)L(2) or Cu(2)(AINS)(4)L(2) formula (L=axial non-NSAID ligand such as diethylether, dimethylsulfoxide DMSO). In zinc(II) complex by DIPS, the metal ion is tetrahedrally coordinated and the corresponding compound is mononuclear with Zn(DIPS)(2)(DMSO)(2) formula. These copper(II) and zinc(II) complexes were found to be more active than their parent drugs from the antiinflammatory and anticonvulsant properties. It was pointed out that the Cu(2)(DIPS)(4)L(2) complexes (L=diethylether, N,N-dimethylformamide) exhibited no rotorod toxicity when examined for anticonvulsant activity using the seizure produced by maximal electroshock, following oral administration to rats.
Viossat
B
B
Laboratoire de Chimie Générale, Faculté de Médecine et de Pharmacie, Poitiers, France.
Morgant
G
G
Sorenson
J R J
JR
Roch-Arveiller
M
M
Daran
J C
JC
Greenaway
F T
FT
Nguyen Huy
D
D
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D002614:Chelating Agents / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D004856:Postural Balance / Q000187:drug effects; D015032:Zinc / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D002614:Chelating Agents; D007202:Indicators and Reagents; D003300:Copper; D015032:Zinc