Binding properties of oligonucleotides containing a modified 2'-deoxyuridine with a thymine ended linker to pair with 2'-deoxyadenosine.
Oligonucleotides containing in the place of thymidine the nucleoside 2, a 2'-deoxyuridine harbouring at C-5 a thymine ended linker, were found to undergo base pairing with the opposite 2'-deoxyadenosine. However, the corresponding duplexes are significantly destabilised as compared to the fully natural ones.
Savy
Pascal
P
Institut de Chimie des Substances Naturelles, CNRS, 91198, Gif-sur-Yvette, France.
Benhida
Rachid
R
Fourrey
Jean Louis
JL
Maurisse
Rosalie
R
Sun
Jian Sheng
JS
D001665:Binding Sites; D003432:Cross-Linking Reagents / Q000737:chemistry; D003839:Deoxyadenosines / Q000737:chemistry*; D003857:Deoxyuridine / Q000737:chemistry*; D004355:Drug Stability; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000493:pharmacokinetics*; D013941:Thymine / Q000737:chemistry
D003432:Cross-Linking Reagents; D003839:Deoxyadenosines; D009841:Oligonucleotides; C058118:2'-deoxyadenosine; D013941:Thymine; D003857:Deoxyuridine