[New knowledge about the mechanisms of pain].
Over the last 10-15 years, scientific knowledge related to the neurobiology of pain systems has expanded substantially. Today the pain system cannot be regarded as static, but one that can undergo substantial neuroplastic changes. These can be increased effectiveness of synaptic transmission, up and/or down regulation of peptides in the dorsal root ganglion, increased and/or decreased expression of receptors. The manifestations of such changes can be pain evoked by normally non-painful stimuli (allodynia) or a heightened reaction to painful stimuli (hyperalgesia). Such reactions are seen in neuropathic pain conditions and are difficult to treat with conventional therapies. In the near future, greater knowledge of the neurobiology of pain may lead to new and more specific analgesics.
Arendt-Nielsen
Lars
L
Center for Sanse-Motorisk Interaktion, Laboratorium for Eksperimentel Smerteforskning, Aalborg Universitet, Fredrik Bajers Vej 7, D3, DK-9220 Aalborg Ø. LAN@smi.auc.dk
D006801:Humans; D008959:Models, Neurological; D009473:Neuronal Plasticity; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000175:diagnosis / Q000503:physiopathology; D059408:Pain Management; D010147:Pain Measurement; D009435:Synaptic Transmission / Q000235:genetics / Q000502:physiology