The turnover of terminal AMP of rat liver tRNA relative to that of internal AMP was studied in presence of various inhibitors. Actinomycin D and aflatoxin B(1), which strongly depress transcription in liver, lead to an increase of the specific radioactivity of external AMP/specific radioactivity of internal AMP ratio. On the contrary, drugs which inhibit the in vivo incorporation of aminoacids determine a significant decrease of this ratio.
Moulé
Y
Y
Institut de Recherches Scientifiques sur le Cancer, 94-, Villejuif, France
Landin
R M.
RM