title: Proton MR spectroscopy of basal ganglia in Wilson's disease: case report and review of literature.
abstract: Volume localized proton Magnetic Resonance Spectroscopy was carried out in both the left and right basal ganglia of three patients with clinically proven Wilson's Disease. While the untreated patient died 15 days after the spectroscopy study, the other 2 patients have been under treatment and have shown clinical improvement. The spectral features of the untreated patient were very different from those of the other two patients who were under treatment and responding. Asymmetrical changes in NAA and Cho were also observed for this patient.
authors.affiliation: Department of NMR, All India Institute of Medical Sciences, New Delhi, India. ramajaysundar@hotmail.com
authors.forename: Rama
authors.initials: R
authors.lastname: Jayasundar
authors.forename: A K
authors.initials: AK
authors.lastname: Sahani
authors.forename: S
authors.initials: S
authors.lastname: Gaikwad
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.forename: M
authors.initials: M
authors.lastname: Behari
mesh_terms: D000293:Adolescent; D001479:Basal Ganglia / Q000378:metabolism*; D002614:Chelating Agents / Q000627:therapeutic use; D002648:Child; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D006527:Hepatolenticular Degeneration / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use; D011736:Pyridoxine / Q000627:therapeutic use
chemical_list: D002614:Chelating Agents; D010396:Penicillamine; D011736:Pyridoxine; D003401:Creatine; D002794:Choline