Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs.
Over the last decades, the interest in the relationships between the pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobial agents has increased and, therefore, the use of PK/PD indices and expressions has spread widely. The appropriate definition and use of these parameters is a matter of controversy. This paper contains a proposal to use PK/PD expressions for antimicrobial agents and their units in a uniform manner.
Mouton
Johan W
JW
Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 sz Nijmegen, The Netherlands. mouton@cwz.nl
Dudley
Michael N
MN
Cars
Otto
O
Derendorf
Hartmut
H
Drusano
George L
GL
D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D009626:Terminology as Topic
D000890:Anti-Infective Agents