Influence of salmon calcitonin on the analgesic effect of selective kappa-opioid agonist in mice.
In the present study the relationship between calcitonin and kappa-opioid system was analysed. The possibility that salmon calcitonin (S-CT) exerts analgesic activity in mice as well as the influence of salmon calcitonin on the analgesic effect of kappa-opioid agonist, U-50, 488H were examined. The writhing test in mice was used as analgesic test. S-CT given alone intraperitoneally at a high dose produced antinociceptive effect. S-CT given at a subanalgesic dose increased the antinociceptive effect of kappa-opioid agonist, U-50, 488H. The obtained results suggest that the increase in the effectiveness of kappa-opioid receptor agonist may be one of the mechanisms involved in the analgesia induced by salmon calcitonin.
Borowicz
B
B
Department of Human Physiology, Medical University of Lublin.
Sagan
M
M
Teter
M
M
Dec-Szlichtyng
M
M
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer / Q000008:administration & dosage; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D004357:Drug Synergism; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice
D000700:Analgesics; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; C028815:salmon calcitonin; D002116:Calcitonin