title: Maternal floor infarction of the placenta: association with central nervous system injury and adverse neurodevelopmental outcome.
abstract: OBJECTIVE
  To compare cranial ultrasound studies and neurodevelopmental outcome of preterm infants affected by maternal floor infarction (MFI) of the placenta to gestational age-matched controls over an 8-year period from a single institution.
  
  
  METHODS
  Retrospective case/control study.
  
  
  RESULTS
  Compared to gestational age-matched controls, infants born to mothers with MFI had a higher incidence of CNS injury on neonatal cranial ultrasound examinations and at follow-up were more likely to have a suspicious or abnormal neurologic examination. MFI cases had lower developmental scores in all areas tested and were more likely to have neurodevelopmental impairment.
  
  
  CONCLUSIONS
  Infants born to mothers with MFI should have serial neonatal cranial ultrasound examinations to detect CNS injury and neurodevelopmental assessment during early childhood.
authors.affiliation: Departments of Pediatrics/Division of Neonatology, Pathology and Reproductive Medicine, University of California at San Diego, San Diego, CA, USA.
authors.forename: Ira
authors.initials: I
authors.lastname: Adams-Chapman
authors.forename: Yvonne E
authors.initials: YE
authors.lastname: Vaucher
authors.forename: Raul F
authors.initials: RF
authors.lastname: Bejar
authors.forename: Kurt
authors.initials: K
authors.lastname: Benirschke
authors.forename: Rebecca N
authors.initials: RN
authors.lastname: Baergen
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Moore
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002490:Central Nervous System / Q000293:injuries; D002493:Central Nervous System Diseases / Q000209:etiology*; D002658:Developmental Disabilities; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology*; D007238:Infarction / Q000150:complications*; D020300:Intracranial Hemorrhages / Q000209:etiology; D008297:Male; D010920:Placenta / Q000098:blood supply*; D021041:Placental Circulation; D011247:Pregnancy; D011256:Pregnancy Outcome; D012886:Skull / Q000000981:diagnostic imaging; D014463:Ultrasonography