Protective effects of the sickle cell gene against malaria morbidity and mortality.
The high frequency of the sickle-cell haemoglobin (HbS) gene in malaria endemic regions is believed to be due to a heterozygote (HbAS) advantage against fatal malaria. Data to prospectively confirm the protection associated with HbAS against mortality are lacking. We show that HbAS provides significant protection against all-cause mortality, severe malarial anaemia, and high-density parasitaemia. This significant reduction in mortality was detected between the ages of 2 and 16 months, the highest risk period for severe malarial anaemia in this area. These data are important in understanding the role of malaria in the selection and maintenance of the sickle cell gene.
Aidoo
Michael
M
Terlouw
Dianne J
DJ
Kolczak
Margarette S
MS
McElroy
Peter D
PD
ter Kuile
Feiko O
FO
Kariuki
Simon
S
Nahlen
Bernard L
BL
Lal
Altaf A
AA
Udhayakumar
Venkatachalam
V
D015331:Cohort Studies; D005838:Genotype; D006801:Humans; D015994:Incidence; D007223:Infant; D007630:Kenya / Q000453:epidemiology; D008288:Malaria / Q000453:epidemiology / Q000401:mortality* / Q000517:prevention & control; D016012:Poisson Distribution; D012805:Sickle Cell Trait / Q000235:genetics*