title: Differential expressions of Fas and Fas ligand in human placenta.
abstract: To investigate the expressions of Fas and Fas ligand (FasL) in human placenta, we studied the expressions of Fas and FasL in placenta with RT-PCR, immunoblotting and immunostaining. We observed amplified products of Fas and FasL transcripts, the band of Fas (52 kDa) and multiple bands of FasL (42-52 kDa) in placenta. Fas and FasL localized mainly on fetal vessels and on syncytiotrophoblasts respectively. The differential distribution of Fas and FasL in human placenta may reflect intrinsic expressions of them by trophoblasts during differentiation. The increased expression of Fas in trophoblasts may promote apoptosis of placenta in pathologic condition such as preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. crroh@smc.samsung.co.kr
authors.forename: Cheong-Rae
authors.initials: CR
authors.lastname: Roh
authors.forename: Jeong-Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Byung-Hee
authors.initials: BH
authors.lastname: Kang
authors.forename: Soon-Ha
authors.initials: SH
authors.lastname: Yang
authors.forename: Byoung-Gie
authors.initials: BG
authors.lastname: Kim
authors.forename: Duk-Soo
authors.initials: DS
authors.lastname: Bae
authors.forename: Jong-Hwa
authors.initials: JH
authors.lastname: Kim
authors.forename: Je-Ho
authors.initials: JH
authors.lastname: Lee
mesh_terms: D053222:Fas Ligand Protein; D015870:Gene Expression; D020869:Gene Expression Profiling; D006031:Glycosylation; D006801:Humans; D015151:Immunoblotting / Q000379:methods; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000235:genetics*; D010920:Placenta / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014327:Trophoblasts / Q000166:cytology / Q000378:metabolism; D019014:fas Receptor / Q000096:biosynthesis / Q000235:genetics*
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor