The WRIST series--what have we learnt?
BACKGROUND
The evolution of the WRIST (Washington Radiation for In-Stent Restenosis Trial) series has reflected the progress that has been made in intracoronary radiation for In-stent restenosis of coronary artery and saphenous vein graft disease. We have enrolled over 1,500 patients in eleven WRIST series performed at the Washington Hospital Center, providing a unique and powerful data set that is pivotal in our understanding of vascular brachytherapy.


OBJECTIVE
This review is intended to give an overview of the individual trials, summarize pertinent lessons that have been learned and give insight into future of intracoronary radiation.
Ajani
Andrew E
AE
Vascular Brachytherapy Institute, Cardiology Research Institute, Washington Cardiology Center, Washington, DC, USA.
Waksman
Ron
R
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001918:Brachytherapy; D000077144:Clopidogrel; D015331:Cohort Studies; D023903:Coronary Restenosis / Q000517:prevention & control*; D000077542:Eptifibatide; D005260:Female; D005500:Follow-Up Studies; D005720:Gamma Rays; D006801:Humans; D007496:Iridium Radioisotopes / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010455:Peptides / Q000008:administration & dosage; D010919:Placebos; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011879:Radiotherapy Dosage; D016032:Randomized Controlled Trials as Topic; D015607:Stents; D013927:Thrombosis / Q000517:prevention & control; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D013997:Time Factors; D015021:Yttrium Radioisotopes / Q000008:administration & dosage
D007496:Iridium Radioisotopes; D010455:Peptides; D010919:Placebos; D010975:Platelet Aggregation Inhibitors; D015021:Yttrium Radioisotopes; D000077144:Clopidogrel; D000077542:Eptifibatide; D013988:Ticlopidine