Rhodium-catalyzed asymmetric ring opening of oxabicyclic alkenes with organoboronic acids.
The first rhodium(I)-catalyzed asymmetric addition of organoboronic acids to oxabicyclic alkenes is reported. This asymmetric ring-opening (ARO) reaction can proceed in high yield under very mild conditions with electronically diverse organoboronic acids, in a highly diastereoselective and enantioselective manner. [structure: see text]
Lautens
Mark
M
Davenport Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5H 3H6. mlautens@chem.utoronto.ca
Dockendorff
Chris
C
Fagnou
Keith
K
Malicki
Adrianna
A