title: Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein.
abstract: Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Src SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised.
authors.affiliation: Aventis Pharma, Paris Research Center, Medicinal Chemistry, 102 route de Noisy, 93235 Cedex, Romainville, France. pierre.deprez@aventis.com
authors.forename: Pierre
authors.initials: P
authors.lastname: Deprez
authors.forename: Eliane
authors.initials: E
authors.lastname: Mandine
authors.forename: Dominique
authors.initials: D
authors.lastname: Gofflo
authors.forename: Stéphane
authors.initials: S
authors.lastname: Meunier
authors.forename: Dominique
authors.initials: D
authors.lastname: Lesuisse
mesh_terms: D001665:Binding Sites; D008024:Ligands; D019000:Phosphotyrosine / Q000378:metabolism*; D018909:src Homology Domains
chemical_list: D008024:Ligands; D019000:Phosphotyrosine