Synthesis and photochemical protein crosslinking studies of hydrophilic naphthalimides.
A mixture of 4-alkylamino-1,8-naphthalimides has previously been reported to exhibit potential utility as a photochemical tissue-bonding reagent. In order to determine which constituents of the mixture were responsible for the observed tissue bonding and to facilitate study of the mechanism, we have synthesized each of the primary constituents of the mixture. Each naphthalimide synthesized has been demonstrated to photochemically crosslink proteins.
Zhang
Jianxing
J
Department of Chemistry & Biochemistry and Center for Drug Discovery, Baylor University, 76798-7348, Waco, TX, USA
Woods
R Jeremy
RJ
Brown
Philip B
PB
Lee
Kap Duk
KD
Kane
Robert R
RR
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D003238:Connective Tissue / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D019920:Photoaffinity Labels / Q000138:chemical synthesis* / Q000737:chemistry; D010777:Photochemistry; D011506:Proteins / Q000737:chemistry*; D012867:Skin / Q000737:chemistry
D000577:Amides; D003432:Cross-Linking Reagents; D009281:Naphthalenes; D019920:Photoaffinity Labels; D011506:Proteins