Novel SNPs in a candidate gene, CRTH2, for allergic diseases.
Sequencing analyses of genomic DNA samples from a Chinese population identified four single-nucleotide polymorphisms (SNPs) of the CRTH2 gene, encoding a chemoattractant receptor predominantly expressed on Th2 cells and a receptor for prostaglandin D2 (PGD2). Two coding-region SNPs with a T to G and a C to A substitutions, resulting in codon changes from Phe to Val and Pro to Thr, respectively. Two additional SNPs were discovered in the 3' untranslated region (3'-UTR). These newly identified SNPs will be useful for further functional study of variant CRTH2 gene, and for genetic studies of asthma and other immunologic diseases.
Hsu
S-C
SC
Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224-6801, USA.
Chen
L-C
LC
Kuo
M-L
ML
Huang
J-L
JL
Huang
S-K
SK
D001483:Base Sequence; D002681:China; D005838:Genotype; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics*; D011982:Receptors, Prostaglandin
D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; C036293:prostaglandin D2 receptor