[Changes of antioxidative capacity and endothelial function before and after treatment among patients with high altitude pulmonary edema].
OBJECTIVE
To investigate the changes of antioxidative capacity and endothelial function among patients with high altitude pulmonary edema (HAPE).


METHODS
The serum levels of SOD, MDA, GSH, NO, NOS and ET-1 were measured before and after treatment among 34 cases of patients with HAPE, and 20 local healthy volunteers served as control.


RESULTS
The serum levels of SOD, GSH, NO and NOS were lower in patient-group before treatment than after treatment and those in control-group significantly (P < 0.01), while the concentration of MDA and ET-1 were higher in patient-group before treatment than after treatment and those in the control-group significantly (P < 0.01). The serum levels of SOD, MDA, GSH, NO, NOS and ET-1 were not different between patient-group after treatment and the control-group (P > 0.05).


CONCLUSIONS
The results indicated that changes of SOD, MDA, GSH, NO, NOS and ET-1 may participate in the course of HAPE.
Fu
Zhongming
Z
Department of Internal Medicine, The 41st Hospital of PLA, Shannan, 856100, China.
Jiang
Ping
P
Ren
Yusheng
Y
Peng
Shunzhou
S
Li
Hong
H
Luo
Xianyang
X
Zou
Zhaoxia
Z
Zhao
Man
M
D000293:Adolescent; D000328:Adult; D000532:Altitude Sickness / Q000097:blood* / Q000473:pathology; D000975:Antioxidants / Q000378:metabolism*; D019332:Endothelin-1 / Q000097:blood; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D019001:Nitric Oxide Synthase / Q000097:blood; D011654:Pulmonary Edema / Q000097:blood* / Q000473:pathology; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D019332:Endothelin-1; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D005978:Glutathione