Effect of vitamin A supplementation on measles-specific antibody levels in Guinea-Bissau.
We have previously reported that vitamin A supplementation with measles vaccine at age 9 months increases measles-specific antibody concentrations in children at age 18 months compared with placebo. We examined these children when they reached age 6-8 years. Fewer vitamin A-supplemented children had non-protective antibody concentrations (p=0.0095); among children with protective antibody levels, vitamin A-supplemented children tended to have higher geometric mean antibody titres (p=0.09). Thus, simultaneous administration of vitamin A and measles vaccine at age 9 months had a long-term effect on measles-specific antibody levels and may contribute to improved measles control in less-developed countries.
Benn
Christine Stabell
CS
Balde
Aliu
A
George
Elisha
E
Kidd
Michael
M
Whittle
Hilton
H
Lisse
Ida Marie
IM
Aaby
Peter
P
D000914:Antibodies, Viral / Q000097:blood*; D002986:Clinical Trials as Topic; D005260:Female; D005500:Follow-Up Studies; D006169:Guinea-Bissau; D006801:Humans; D007223:Infant; D008297:Male; D008457:Measles / Q000276:immunology* / Q000401:mortality / Q000517:prevention & control; D008458:Measles Vaccine; D014801:Vitamin A / Q000627:therapeutic use*
D000914:Antibodies, Viral; D008458:Measles Vaccine; D014801:Vitamin A