A highly reactive titanium precatalyst for intramolecular hydroamination reactions.
[reaction: see text]. Tetrakisamido titanium complexes are significantly more active than Cp2TiMe2 (1) in the intramolecular hydroamination of aminoalkynes and aminoallenes. In the latter case, the regioselectivity of the transformation depends on the nature of the precatalyst, yielding the most selective and reactive catalysis with the bis(sulfonamido) complex 11.
Ackermann
Lutz
L
Department of Chemistry and Center for New Directions in Organic Synthesis, University of California, Berkeley, California 94720-1460, USA.
Bergman
Robert G
RG
D000586:Amination; D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D014025:Titanium / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry
D000588:Amines; D015040:Zirconium; D014025:Titanium