GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing: a combined fMRI/MEG study with placebo and lorazepam.
Various prefrontal cortical regions have been shown to be activated during emotional stimulation, whereas neurochemical mechanisms underlying emotional processing in the prefrontal cortex remain unclear. We therefore investigated the influence of the GABA-A potentiator lorazepam on prefrontal cortical emotional-motor spatio-temporal activation pattern in a combined functional magnetic resonance imaging/magnetoencephalography study. Lorazepam led to the reversal in orbito-frontal activation pattern, a shift of the early magnetic field dipole from the orbito-frontal to medial prefrontal cortex, and alterations in premotor/motor cortical function during negative and positive emotional stimulation. It is concluded that negative emotional processing in the orbito-frontal cortex may be modulated either directly or indirectly by GABA-A receptors. Such a modulation of orbito-frontal cortical emotional function by lorazepam has to be distinguished from its effects on cortical motor function as being independent from the kind of processing either emotional or nonemotional.
Northoff
Georg
G
Department of Neurology, Section of Behavioral Neurology, Beth Israel Deaconess Medical Center, Harvard University, Kirstein Building KS 454, 330 Brookline Avenue, Boston, 02215 MA, USA. gnorthof@caregroup.harvard.edu
Witzel
Thomas
T
Richter
Andre
A
Gessner
Matthias
M
Schlagenhauf
Florian
F
Fell
Jürgen
J
Baumgart
Frank
F
Kaulisch
Thomas
T
Tempelmann
Claus
C
Heinzel
Alexander
A
Kötter
Rolf
R
Hagner
Tilman
T
Bargel
Bela
B
Hinrichs
Hermann
H
Bogerts
Bernhard
B
Scheich
Henning
H
Heinze
Hans-Jochen
HJ
D000328:Adult; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D004311:Double-Blind Method; D004644:Emotions / Q000502:physiology*; D005260:Female; D018757:GABA Modulators / Q000008:administration & dosage*; D006801:Humans; D008140:Lorazepam / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D018757:GABA Modulators; D005680:gamma-Aminobutyric Acid; D008140:Lorazepam