title: Imiquimod 5% cream is an acceptable treatment option for external anogenital warts in uncircumcised males.
abstract: OBJECTIVE
  To determine the safety and efficacy of imiquimod (Aldara) 5% cream in the treatment of prepuce-associated warts in uncircumcised males.
  
  
  METHODS
  An open-label study in six UK medical centres with 35 uncircumcised males with prepuce-associated warts treated with imiquimod 5% cream three times per week for up to 16 weeks. Other anogenital warts were also treated.
  
  
  RESULTS
  Three times weekly application of imiquimod was found to be safe, with erythema as the most commonly reported local skin reaction. Forty per cent of patients had complete clearance of anogenital warts within 16 weeks.
  
  
  CONCLUSIONS
  Imiquimod cream at a dosing regimen of three times per week, is effective and has an acceptable safety profile in the treatment of prepuce associated warts and other external anogenital warts in uncircumcised males.
authors.affiliation: Department of Genitourinary Medicine, Royal Victoria Hospital, Belfast, Northern Ireland, UK. raymond.maw@royalhospitals.n-i.nhs.uk
authors.forename: R D
authors.initials: RD
authors.lastname: Maw
authors.forename: G R
authors.initials: GR
authors.lastname: Kinghorn
authors.forename: C A
authors.initials: CA
authors.lastname: Bowman
authors.forename: B T
authors.initials: BT
authors.lastname: Goh
authors.forename: A T
authors.initials: AT
authors.lastname: Nayagam
authors.forename: M
authors.initials: M
authors.lastname: Nathan
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000634:Aminoquinolines / Q000009:adverse effects / Q000627:therapeutic use*; D003218:Condylomata Acuminata / Q000188:drug therapy*; D006801:Humans; D000077271:Imiquimod; D007369:Interferon Inducers / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009824:Ointments; D010409:Penile Diseases / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000634:Aminoquinolines; D007369:Interferon Inducers; D009824:Ointments; D000077271:Imiquimod