title: Fluorescent tetracycline labeling as an aid to debridement of necrotic bone in the treatment of chronic osteomyelitis.
abstract: The authors have found that several months of preoperative tetracycline administration will label living bone so that it fluoresces under a blacklight during surgery. This allows intraoperative differentiation of viable bone from necrotic sequestra, which require removal in the treatment of chronic bone infection.
authors.affiliation: Department of Orthopaedics, University of North Carolina, Campus Box 7055, Chapel Hill, NC 27599, USA.
authors.forename: Laurence E
authors.initials: LE
authors.lastname: Dahners
authors.forename: Gary D
authors.initials: GD
authors.lastname: Bos
mesh_terms: D002908:Chronic Disease; D003646:Debridement / Q000379:methods; D005453:Fluorescence; D006801:Humans; D007202:Indicators and Reagents; D010019:Osteomyelitis / Q000150:complications / Q000601:surgery*; D010020:Osteonecrosis / Q000209:etiology / Q000601:surgery*; D011300:Preoperative Care / Q000379:methods; D012680:Sensitivity and Specificity; D013752:Tetracycline / Q000008:administration & dosage*
chemical_list: D007202:Indicators and Reagents; D013752:Tetracycline