Common human leucocyte antigen haplotypes in Indians--its implications in finding unrelated compatible bone marrow donors.
All over the world there have been efforts to make unrelated stem cell registries to cater for patients who do not have a compatible family donor and are in need of allogenic stem cell transplantation. Donors of Indian origin are poorly represented all these registries. Approximately 10 million Indians live outside India, and a substantial number of them live in the developed West. Hence when some of these patients of Indian origin need unrelated stem cell donor, they search the available National Marrow Donor Program (NMDP) registry database and invariably do not get a human leucocyte antigen (HLA) matched donor. They come to India, where a haphazard search for the donor ensues and it invariably ends in failure. Hence, we have compiled the data of our laboratory and other published reports in population HLA studies from India and abroad to show several common haplotypes from these studies. It is hoped that this will give the busy clinician an idea whether a search for prospective unrelated stem cell donor for an Indian patient is likely to succeed or not.
Ghosh
K
K
HLA Department, Institute of Immunohaematology (ICMR), 13th Floor, K. E. M. Hospital, Mumbai, India. kanjakshaghosh@hotmail.com
Shankarkumar
U
U
Mohanty
D
D
D016026:Bone Marrow Transplantation / Q000276:immunology*; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes / Q000276:immunology*; D006648:Histocompatibility; D006801:Humans; D007194:India; D015810:Linkage Disequilibrium; D012042:Registries / Q000592:standards; D014019:Tissue Donors; D014184:Transplantation, Homologous / Q000276:immunology
D006680:HLA Antigens