title: Effects of endoscopic variceal treatment on oesophageal function: a prospective, randomized study.
abstract: OBJECTIVE
  Endoscopic methods are currently the most widely used techniques for the treatment of bleeding oesophageal varices (BOV). However, a number of complications may limit their usefulness. We conducted a prospective, randomized comparison of variceal ligation versus sclerotherapy in cirrhotics after the control of variceal haemorrhage to study the relative short-term risks of these two procedures with respect to oesophageal motility and gastro-oesophageal reflux.
  
  
  METHODS
  Seventy-three patients with established cirrhosis and an episode of variceal bleeding controlled by one session of endoscopic therapy were randomized to treatment with sclerotherapy or ligation until variceal eradication. In 60 of these patients, oesophageal manometry and 24-h intra-oesophageal pH monitoring were performed at inclusion and 1 month after variceal eradication.
  
  
  RESULTS
  After variceal eradication with sclerotherapy, peristaltic wave amplitude decreased from 76.2 +/- 14.7 mmHg to 61.6 +/- 17.7 mmHg (P = 0.0001), simultaneous contractions increased from 0% to 37.9% (P = 0.0008), and the percentage of time with pH < 4 increased from 1.60 +/- 0.25 to 4.91 +/- 1.16% in channel 1 (P = 0.0002) and from 1.82 +/- 0.27 to 5.69 +/- 1.37% in channel 2 (P = 0.0006). In contrast, the above parameters were not disturbed with ligation.
  
  
  CONCLUSIONS
  Our data define the advantages of ligation over sclerotherapy with respect to post-treatment oesophageal dysmotility and associated gastro-oesophageal reflux.
authors.affiliation: Second Departments of Gastroenterology, Athens University, Athens, Greece.
authors.forename: Nikos
authors.initials: N
authors.lastname: Viazis
authors.forename: Anastasios
authors.initials: A
authors.lastname: Armonis
authors.forename: Jiannis
authors.initials: J
authors.lastname: Vlachogiannakos
authors.forename: George
authors.initials: G
authors.lastname: Rekoumis
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Stefanidis
authors.forename: Nikos
authors.initials: N
authors.lastname: Papadimitriou
authors.forename: Spilios
authors.initials: S
authors.lastname: Manolakopoulos
authors.forename: Alec
authors.initials: A
authors.lastname: Avgerinos
mesh_terms: D004932:Esophageal and Gastric Varices / Q000503:physiopathology / Q000628:therapy*; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000628:therapy*; D016558:Hemostasis, Endoscopic; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008026:Ligation; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010528:Peristalsis; D011446:Prospective Studies; D015911:Sclerotherapy