Acid phosphatases.
Acid phosphatases (APs) are a family of enzymes that are widespread in nature, and can be found in many animal and plant species. Mystery surrounds the precise functional role of these molecular facilitators, despite much research. Yet, paradoxically, human APs have had considerable impact as tools of clinical investigation and intervention. One particular example is tartrate resistant acid phosphatase, which is detected in the serum in raised amounts accompanying pathological bone resorption. This article seeks to explore the identity and diversity of APs, and to demonstrate the relation between APs, human disease, and clinical diagnosis.
Bull
H
H
Human and Clinical Research Group, School of Nursing, University of Nottingham, Derbyshire Royal Infirmary, Derby DE1 2QY, UK.
Murray
P G
PG
Thomas
D
D
Fraser
A M
AM
Nelson
P N
PN
D000135:Acid Phosphatase / Q000032:analysis / Q000172:deficiency / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001862:Bone Resorption / Q000378:metabolism*; D005236:Favism / Q000175:diagnosis; D005776:Gaucher Disease / Q000175:diagnosis; D006801:Humans; D007424:Intracellular Fluid / Q000201:enzymology; D007527:Isoenzymes / Q000032:analysis / Q000172:deficiency / Q000378:metabolism*; D007943:Leukemia, Hairy Cell / Q000175:diagnosis; D008297:Male; D010010:Osteoclasts / Q000201:enzymology*; D010024:Osteoporosis / Q000201:enzymology*; D011467:Prostate; D011471:Prostatic Neoplasms / Q000175:diagnosis; D011485:Protein Binding; D017382:Reactive Oxygen Species / Q000378:metabolism; D000071681:Tartrate-Resistant Acid Phosphatase; D000511:alpha-Macroglobulins / Q000378:metabolism
D015415:Biomarkers; D007527:Isoenzymes; D017382:Reactive Oxygen Species; D000511:alpha-Macroglobulins; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase