title: [Role of interferon alpha in the management of severe acute pancreatitis].
abstract: OBJECTIVE
  To investigate the efficacy of IFN-alpha on severe acute pancreatitis (SAP) of IFN-alpha.
  
  
  METHODS
  A SAP model was developed in adult male rats by retrograde injection of 5% sodium taurocholate in the pancreatic duct. Serum amylase was measured by the blue-starch method and serum cytokines were determined by ELISA.
  
  
  RESULTS
  Compared with to the control group, less pancreatic injury and lower amylase level were observed treat in the rats with IFN-alpha. In contrast, the concentration of IL-10 was higher.
  
  
  CONCLUSIONS
  IFN-alpha has significant curative effect on SAP.
authors.affiliation: Department of Surgery, Ruijin Hospital of Shanghai Second Medical University, Shanghai 200025, China.
authors.forename: Yaoqing
authors.initials: Y
authors.lastname: Tang
authors.forename: Dachuan
authors.initials: D
authors.lastname: Qi
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Enqiang
authors.initials: E
authors.lastname: Mao
authors.forename: Jun
authors.initials: J
authors.lastname: Ji
authors.forename: Tianquan
authors.initials: T
authors.lastname: Han
authors.forename: Shendao
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007155:Immunologic Factors / Q000627:therapeutic use*; D016898:Interferon-alpha / Q000627:therapeutic use*; D016753:Interleukin-10 / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008297:Male; D019283:Pancreatitis, Acute Necrotizing / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D007155:Immunologic Factors; D016898:Interferon-alpha; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10