Silyl-substituted amino acids: new routes to the construction of selectively functionalized peptidomimetics.
[reaction: see text]. Silylated amino acids have been incorporated into peptides and then converted into N-acyliminium ions with the use of an anodic oxidation reaction. The result is a method for selectively incorporating conformational constraints or external nucleophiles within the peptide.
Sun
Haizhou
H
Department of Chemistry, Washington University, St. Louis, Missouri 63130, USA.
Moeller
Kevin D
KD
D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D003500:Cyclization; D007202:Indicators and Reagents; D007769:Lactams / Q000138:chemical synthesis; D018716:Molecular Mimicry; D010084:Oxidation-Reduction; D010455:Peptides / Q000138:chemical synthesis*; D017655:Silicon Compounds / Q000737:chemistry*
D000596:Amino Acids; D007202:Indicators and Reagents; D007769:Lactams; D010455:Peptides; D017655:Silicon Compounds