Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas.
Stem cell research and the prospect of stem cell based therapies depend critically on the identification of specific markers that can be used for the identification and selection of stem and progenitor cells. Nestin is expressed in neuronal progenitor cells and has also been suggested to mark multipotent pancreatic stem cells. We show here that, throughout pancreatic development, markers of pancreatic progenitor cells and differentiated pancreatic cells are expressed in E-cadherin-positive epithelial cells that do not express nestin. The data presented demonstrate that nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas.
Selander
Lars
L
Department of Molecular Biology, Umeå Center for Molecular Medicine, Umeå University, SE-901 87 Umea, Sweden.
Edlund
Helena
H
D000818:Animals; D015820:Cadherins / Q000096:biosynthesis; D004847:Epithelial Cells / Q000378:metabolism*; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000096:biosynthesis*; D008648:Mesoderm / Q000378:metabolism*; D051379:Mice; D018613:Microscopy, Confocal; D009419:Nerve Tissue Proteins; D064231:Nestin; D010179:Pancreas / Q000196:embryology*; D013997:Time Factors
D015820:Cadherins; D007381:Intermediate Filament Proteins; D009419:Nerve Tissue Proteins; C577485:Nes protein, mouse; D064231:Nestin