[Protective effect of exogenous glial cell line  derived neurotrophic factor on neurons after sciatic nerve injury in rats].
The aim of the study was to investigate the effect of exogenous glial cell line  derived neurotrophic factor (GDNF) on spinal cord neurons after sciatic nerve axotomy. Upon silicone  tubulization of transected sciatic nerve in the adult rat, either 0.9% saline or GDNF solution was injected into the silicone chamber. It was observed by Nissl and enzyme histochemistry staining that exogenous GDNF decreased lesion  induced motor neuron death in lateral nucleus of spinal anterior horn and the changes in activity of cholinesterase and acid phosphatase in spinal cord and sensory ganglions. These results suggest that exogenous GDNF is capable of protecting motor neurons from death induced by peripheral nerve injury.
Chen
Z Y
ZY
Department of Neurobiology, Second Military Medical University, Shanghai 200433, China. luchlink@online.sh.cn
Cao
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Lu
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CL
He
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Bao
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D000818:Animals; D019771:Axotomy; D051100:Glial Cell Line-Derived Neurotrophic Factor; D008297:Male; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D009414:Nerve Growth Factors / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology; D012584:Sciatic Nerve / Q000293:injuries*; D013116:Spinal Cord / Q000187:drug effects / Q000503:physiopathology*
C495041:Gdnf protein, rat; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D011994:Recombinant Proteins