title: The role of inflammatory cytokines in Meigs' syndrome.
abstract: BACKGROUND
  Inflammatory cytokines are known to induce capillary leakage and third-space fluid accumulation in numerous gynecologic and nongynecologic disorders. This study aimed to assess their role in Meigs' syndrome.
  
  
  METHODS
  Evaluation of serum, peritoneal, and pleural fluids retrieved from a patient suffering from Meigs' syndrome revealed high interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha levels. After surgical removal of the ovarian tumor and with resolution of ascites and hydrothorax, serum levels of IL-1beta, IL-6, and IL-8 declined, whereas tumor necrosis factor-alpha levels remained high.
  
  
  CONCLUSIONS
  The correlation between these inflammatory cytokines and the clinical course of Meigs' syndrome suggests their involvement in the formation of ascites and hydrothorax in this disorder.
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Ein-Kerem, Jerusalem, Israel. abramo@md2huji
authors.forename: Yoram
authors.initials: Y
authors.lastname: Abramov
authors.forename: Shaoul O
authors.initials: SO
authors.lastname: Anteby
authors.forename: Sozos J
authors.initials: SJ
authors.lastname: Fasouliotis
authors.forename: Vivian
authors.initials: V
authors.lastname: Barak
mesh_terms: D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008539:Meigs Syndrome / Q000276:immunology* / Q000601:surgery; D017698:Postmenopause; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha