Why FRET about Ran?
The Ran GTPase drives nucleocytoplasmic transport, stabilizes mitotic spindles, and catalyzes nuclear envelope formation. A unifying explanation of these functions is that RanGTP produces an organizing field or "atmosphere" around chromatin and acts as a spatial marker. This RanGTP field has now been visualized using fluorescent biosensors.
Macara
Ian G
IG
Center for Cell Signaling, and Department of Pharmacology, Box 800577, HSC, University of Virginia, Charlottesville, VA 22908, USA.
D002843:Chromatin / Q000378:metabolism; D008856:Microscopy, Fluorescence / Q000379:methods*; D020931:ran GTP-Binding Protein / Q000032:analysis* / Q000378:metabolism*
D002843:Chromatin; D020931:ran GTP-Binding Protein