High density lipoprotein-cholesterol changes in children with high cholesterol levels at birth.
The predictive value of serum lipoprotein concentrations at birth for the same parameters later in life is under debate. A group of 20 children displaying high total cholesterol (TC) levels at birth (group 2) were compared at age 4 years with 18 control children who had presented a normal lipoprotein profile at birth (group 1). There was a significant correlation between TC, low density lipoprotein-cholesterol, high density lipoprotein (HDL)-cholesterol, and apolipoprotein (Apo) A-I levels at age 4 years and at birth. The increases in TC and HDL-cholesterol levels from birth to age 4 years were significantly lower (P < 0.05, P < 0.01, respectively) in group 2 than in the control group and inversely correlated with the concentrations of these parameters at birth. The increases in HDL-cholesterol and Apo A-I levels were higher in males while those of triacylglycerol and Apo B were higher in females (P < 0.05). However, the increases in TC and HDL-cholesterol were higher in controls (P< 0.05). Diets of children of both groups were similar regarding the energy contribution of saturated, monounsaturated and polyunsaturated fatty acids, although children from group 2 ate less fish and omega-3 fatty acids (P < 0.05).


CONCLUSIONS
the present data suggest for the first time that when high density lipoprotein-cholesterol levels are high at birth, those levels increase less during the first four years of life. Moreover, low density lipoprotein-cholesterol increased about five times as much as high density lipoprotein-cholesterol did in controls and about 15 times as much as in the children with high cholesterol at birth.
Bastida
Sara
S
Departamento de Nutrición, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Sánchez-Muniz
Francisco J
FJ
Cuena
Rafael
R
Perea
Sagrario
S
Aragonés
Angel
A
D000367:Age Factors; D000704:Analysis of Variance; D000886:Anthropometry; D001057:Apolipoproteins E / Q000032:analysis / Q000097:blood*; D016022:Case-Control Studies; D002657:Child Development / Q000502:physiology; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000032:analysis / Q000097:blood*; D008078:Cholesterol, LDL / Q000032:analysis / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006937:Hypercholesterolemia / Q000175:diagnosis*; D007231:Infant, Newborn; D008297:Male; D008403:Mass Screening; D011446:Prospective Studies; D012016:Reference Values; D012680:Sensitivity and Specificity
D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL