title: [Expression of telomerase genes in mamary atypical ductal hyperplasia].
abstract: OBJECTIVE
  To investigate the relationship of telomerase genes and the malignant transformation of atypical mammary ductal hyperplasia.
  
  
  METHODS
  Telomerase genes hTR and hTRT in 50 cases of mammary hyperplasia (the cases included 6 benign hyperplasia, 9 mild atypical hyperplasia, 12 medium atypical hyperplasia, 23 severe atypical hyperplasia) and 26 cases of breast carcinoma were detected by in situ hybridization.
  
  
  RESULTS
  The expression of hTR and hTRT mRNA were weak or negative in benign hyperplasia (1/6, 0), weaker in mild-moderate atypical hyperplasia (2/9, 1/9, 4/12, and 3/12), strong in severe atypical hyperplasia (14/23, 60.9% and 12/23, 52.1%), while very strong expression (23/26, 88.5% and 21/25, 80.8%) in carcinoma of the breast. The difference between mild-moderate atypical hyperplasia, invasive ductal carcinoma and severe atypical hyperplasia was significant (P < 0.05) and the difference between severe atypital hyperplasia and intraductal carcinoma was not significant (P > 0.05).
  
  
  CONCLUSIONS
  Telmerase genes (hTR, hTRT) expression is closely related to the malignant transformation of atypical hyperplasia. The reactivated telomerase may play a crucial role in the development of breast cancer.
authors.affiliation: Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China.
authors.forename: Min
authors.initials: M
authors.lastname: Song
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Mi
authors.forename: Bailin
authors.initials: B
authors.lastname: Li
authors.forename: Jijiang
authors.initials: J
authors.lastname: Zhu
authors.forename: Yingxian
authors.initials: Y
authors.lastname: Gao
authors.forename: Shuang
authors.initials: S
authors.lastname: Cui
authors.forename: Jiye
authors.initials: J
authors.lastname: Song
mesh_terms: D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000201:enzymology* / Q000473:pathology; D004268:DNA-Binding Proteins; D005260:Female; D015870:Gene Expression; D006801:Humans; D012333:RNA, Messenger; D019098:Telomerase / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D019098:Telomerase