Angiogenic cytokines in cartilage tumors.
Pathologic neovascularization has been described in numerous types of cancers. The angiogenic cytokines vascular endothelial growth factor and basic fibroblast growth factor are thought to be the primary inducers of angiogenesis in these tumors. Hypoxia-inducible transcription factor is a nuclear transcription factor that promotes vascular endothelial growth factor expression. Prior studies have shown pathologic neovascularization in chondrosarcoma, which correlates with pathologic grade of the tumor. Angiogenic and nonangiogenic cartilage tumors were studied for expression of vascular endothelial growth factor, basic fibroblast growth factor and hypoxia-inducible transcription factors by immunohistochemistry and Northern blot analysis. Expression of vascular endothelial growth factor and hypoxia-inducible transcription factor were increased significantly in angiogenic tumors. Fibroblast growth factor expression was similar in angiogenic and nonangiogenic specimens. This may have implications for tumor grading and surgical decision-making, and potential treatment with antiangiogenesis chemotherapeutic agents.
McGough
Richard L
RL
Department of Orthopaedics, Brown University and Rhode Island Hospital, Providence, RI, USA.
Lin
Chuzhao
C
Meitner
Patricia
P
Aswad
Bassam I
BI
Terek
Richard M
RM
D015152:Blotting, Northern; D001859:Bone Neoplasms / Q000098:blood supply / Q000378:metabolism*; D002813:Chondrosarcoma / Q000098:blood supply / Q000378:metabolism*; D016228:Endothelial Growth Factors / Q000378:metabolism*; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008222:Lymphokines / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D017411:Ribonucleoproteins, Small Nuclear; D015534:Trans-Activators / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D017411:Ribonucleoproteins, Small Nuclear; C411898:Sart1 protein, mouse; D015534:Trans-Activators; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D016222:Fibroblast Growth Factor 2