[Corneal descompensation in patients with endothelial compromise treated with topical dorzolamide].
OBJECTIVE
To investigate the possibility of corneal alterations in patients with long-term endothelial compromise with topical dorzolamide.


METHODS
Retrospective descriptive study of 17 patients with penetrating keratoplasty and glaucoma associated with topical carbonic anhydrase inhibitor therapy, looking for coincidence with corneal alteration.


RESULTS
Classified by ethiology, type of glaucoma and control, recording previous ophthalmological surgeries, evolution time, complications and rejection episodes. Seven patients suffered a corneal decompensation, in three of them there were signs of true reject but only four cases had edema at the beginning of dorzolamide treatment, one of them recovering after stopping dorzolamide. Risk factors were previous cataract surgery, mainly aphakia, filtering surgery and previous vitrectomy.


CONCLUSIONS
Dorzolamide could have a potential negative effect on patients with endothelial compromise.
Domingo Gordo
B
B
Servicio de Oftalmología, Hospital General Universitario Gregorio Marañón, Madrid, España. domingoblanco@hotmail.com
Urcelay Segura
J L
JL
Conejero Arroyo
J
J
Balado Vázquez
P
P
Rodríguez Ausín
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects* / Q000601:surgery; D004728:Endothelium, Corneal / Q000187:drug effects; D018463:Filtering Surgery; D005901:Glaucoma / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013449:Sulfonamides / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*; D014821:Vitrectomy / Q000009:adverse effects
D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide