title: Measurement of vessel wall strain using cine phase contrast MRI.
abstract: OBJECTIVE
  To determine the feasibility of using magnetic resonance imaging (MRI) to non-invasively measure strain in the aortic wall.
  
  
  METHODS
  Cine phase contrast MRI was used to measure the velocity of the aortic wall and calculate changes in circumferential strain over the cardiac cycle. A deformable vessel phantom was used for initial testing and in vitro validation. Ultrasonic sonomicrometer crystals were attached to the vessel wall and used as a gold standard.
  
  
  RESULTS
  In the in vitro validation, MRI-calculated wall displacements were within 0.02 mm of the sonomicrometer measurements when maximal displacement was 0.28 mm. The measured maximum strain in vitro was 0.02. The in vivo results were on the same order as prior results using ultrasound echo-tracking.
  
  
  CONCLUSIONS
  Results of in vivo studies and measurement of cyclic strain in human thoracic and abdominal aortas demonstrate the feasibility of the technique.
authors.affiliation: Department of Radiology, Stanford University, Stanford, California 94304, USA.
authors.forename: Kristin L
authors.initials: KL
authors.lastname: Wedding
authors.forename: Mary T
authors.initials: MT
authors.lastname: Draney
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Herfkens
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Zarins
authors.forename: Charles A
authors.initials: CA
authors.lastname: Taylor
authors.forename: Norbert J
authors.initials: NJ
authors.lastname: Pelc
mesh_terms: D001011:Aorta / Q000502:physiology*; D001012:Aorta, Abdominal / Q000502:physiology; D001013:Aorta, Thoracic / Q000502:physiology; D001696:Biomechanical Phenomena; D005240:Feasibility Studies; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008954:Models, Biological; D009038:Motion