[Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, Pariparoba].
Four known compounds have been isolated from the aerial parts of the Brazilian medicinal plant Pariparoba (Pothomorphe umbellata). They were an alkaloid, a flavone, a dihydrocalcone, and a steroid. The chemical structures were established to be N-benzoylmescaline, wogonin, uvangoletin, and beta-sitosterol glucoside using spectral methods. Among these compounds, the main component N-benzoylmescaline showed significant antibacterial activity against Helicobacter pylori.
Isobe
Takahiko
T
Department of Chemistry, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya City, Hyogo 663-8501, Japan. isobetkh@hyo-med.ac.jp
Ohsaki
Ayumi
A
Nagata
Kumiko
K
D024881:Drug Resistance, Bacterial; D016480:Helicobacter pylori / Q000187:drug effects; D008635:Mescaline / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship
C454925:N-benzoylmescaline; D008635:Mescaline