title: Assessment of photoplethysmographic signals for the determination of splanchnic oxygen saturation in humans.
abstract: The need for a clinically applicable method of detecting splanchnic hypoxia has led to experimental animal studies which indicated the usefulness of intestinal pulse oximetry. Pulse oximetry relies on detection of photoplethysmographic signals. Before developing a pulse oximeter for the measurement of organ oxygen saturation peri-operatively, we designed a system based on a reflectance photoplethysmographic probe to investigate photoplethysmographic signals from human viscera (bowel, liver, and kidney). Recordings were obtained simultaneously from the abdominal viscera and the finger using identical probes. The probe was held sequentially for up to 2 min on the surface of viscera of 12 patients during routine laparotomy. Measurable splanchnic photoplethysmographic signals were recorded for the first time in humans. There were no statistically significant differences between photoplethysmographic amplitudes from viscera and those from the finger. Our results indicate the feasibility of pulse oximetry for the measurement of visceral oxygenation in humans.
authors.affiliation: Anaesthetics Laboratory, St Bartholomew's Hospital, Barts and the London NHS Trust, London EC1A 7BE, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Crerar-Gilbert
authors.forename: P A
authors.initials: PA
authors.lastname: Kyriacou
authors.forename: D P
authors.initials: DP
authors.lastname: Jones
authors.forename: R M
authors.initials: RM
authors.lastname: Langford
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007813:Laparotomy; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D017156:Photoplethysmography; D013152:Splanchnic Circulation
chemical_list: D010100:Oxygen