Electrical recordings from rat cardiac muscle cells using field-effect transistors.
Extracellular electrophysiological recordings were made from cardiac cells cultured for up to seven days over microfabricated arrays of field-effect transistors. The recorded signals can be separated mainly into two types of cell transistor couplings: one that can be explained entirely by purely passive circuitry elements, and a second where voltage-gated ion channels contribute greatly to the measured extracellular signal.
Sprössler
C
C
Max-Planck-Institute for Polymer Research, Ackermannweg 10, D-55128 Mainz, Germany.
Denyer
M
M
Britland
S
S
Knoll
W
W
Offenhäusser
A
A
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002478:Cells, Cultured; D003198:Computer Simulation; D005109:Extracellular Matrix / Q000502:physiology; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000502:physiology; D008954:Models, Biological; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D012828:Silicones / Q000378:metabolism; D014173:Transistors, Electronic
D007473:Ion Channels; D012828:Silicones