title: rpoB mutation conferring rifampin resistance in Streptococcus pyogenes.
abstract: Streptococcus pyogenes BM4478 and Staphylococcus aureus BM4479 were isolated from a patient undergoing rifampin therapy. High-level resistance to rifampin was due to the following mutations in the rpoB gene: Ser522Leu in strain BM4478 and His526Asn and Ser574Leu in strain BM4479.
authors.affiliation: Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Aubry-Damon
authors.forename: Marc
authors.initials: M
authors.lastname: Galimand
authors.forename: Guy
authors.initials: G
authors.lastname: Gerbaud
authors.forename: Patrice
authors.initials: P
authors.lastname: Courvalin
mesh_terms: D000595:Amino Acid Sequence; D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D012293:Rifampin / Q000494:pharmacology*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics
chemical_list: D012321:DNA-Directed RNA Polymerases; C105078:RNA polymerase beta subunit; D012293:Rifampin