[The function of accessory genes of HIV-1].
Human immunodeficiency virus type 1 (HIV-1) has 4 auxiliary genes, vpr, vpu, nef, and vif, which are dispensable for viral replication in vitro. However, many studies with animal model revealed that these genes play important roles on the viral replication and the development of AIDS in vivo through many complicated mechanisms. Although several key factors involved in the function have been identified, further studies are required for the complete understandings of the action mechanisms. The elucidation of the function of the auxiliary genes on molecular bases leads to the discovery of new therapeutic strategies against HIV and the understanding of basic cellular mechanisms. In this review, we summarize new observations mainly about the interactions between auxiliary genes and host cell functions.
Ueno
Takaharu
T
Laboratory of Gene Analysis, Department of Viral Oncology, Institute for Virus Research, Kyoto University.
Sakai
Hiroyuki
H
D000163:Acquired Immunodeficiency Syndrome / Q000821:virology; D000818:Animals; D015754:Genes, nef / Q000502:physiology*; D016341:Genes, vif / Q000502:physiology*; D016334:Genes, vpr / Q000502:physiology*; D016338:Genes, vpu / Q000502:physiology*; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology; D006801:Humans; D014779:Virus Replication