title: [The changes of cardiovascular response to orthostatic stress caused by hypovolemia induced by weightlessness: a simulation study].
abstract: We introduced the method of computer simulation in the studies of gravitational physiology. Based on work of Melchior (1994), we developed a mathematical model that can be used to stimulate cardiovascular responses to orthostatic stress (lower body negative pressure, LBNP). The model includes 7 sub-models: the redistribution of blood, the filling of left ventricle, left ventricle working, peripheral circulation, control of heart rate (HR), control of peripheral resistance and control of venous tone. Then we simulated the changes of blood pressure (BP) and heart rate during lower body negative pressure, and the results agreed well with the results of our human experiment. By using the developed model, we also simulated the effects of hypovolemia on the BP, HR and shock index during orthostatic stress. The simulation results indicate that the cardiovascular responses to orthostatic stress change significantly when the decrease of blood volume is more than 15% of the total blood volume. However, if the amount of the decrease of blood volume is less than 5% of the total blood volume, HR and BP could be maintained in normal range by the regulation of baroreflex during LBNP. Our simulation results suggest that hypovolemia may be the main cause of orthostatic intolerance induced by weightlessness.
authors.affiliation: Department of Electrical Engineering, Tsinghua University, Beijing 100084.
authors.forename: Weiya
authors.initials: W
authors.lastname: Hao
authors.forename: Jing
authors.initials: J
authors.lastname: Bai
authors.forename: Lifan
authors.initials: L
authors.lastname: Zhang
authors.forename: Xingyu
authors.initials: X
authors.lastname: Wu
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D018493:Cardiovascular Deconditioning / Q000502:physiology*; D003198:Computer Simulation; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology / Q000503:physiopathology*; D020896:Hypovolemia / Q000209:etiology / Q000503:physiopathology*; D008150:Lower Body Negative Pressure / Q000009:adverse effects*; D008297:Male; D008955:Models, Cardiovascular; D016277:Ventricular Function, Left / Q000502:physiology; D018474:Weightlessness Simulation / Q000009:adverse effects*