Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters.
Iodinated 3beta-aryltropanes functionalized appropriately at the 2beta-, 8- and aryl positions display selective binding to either the dopamine or serotonin transporters.
Davies
Huw M L
HM
Department of Chemistry, State University of New York at Buffalo, 14260-3000, USA. hdavies@pop.ascu.buffalo.edu
Ren
Pingda
P
Kong
Norman X
NX
Sexton
Tammy
T
Childers
Steven R
SR
D001665:Binding Sites; D001667:Binding, Competitive; D002352:Carrier Proteins / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins; D006847:Hydrocarbons, Iodinated / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D012701:Serotonin / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins; D013329:Structure-Activity Relationship; D014326:Tropanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D006847:Hydrocarbons, Iodinated; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins; D014326:Tropanes; D012701:Serotonin; D004298:Dopamine