(4-Methoxy-benzylidene)-(3-methoxy-phenyl)-amine, a nitrogen analog of stilbene as a potent inhibitor of melanin production.
The current study was carried out to investigate in vitro the effects of (4-methoxy-benzylidene)-(3-methoxyphenyl)-amine on melanin biosynthesis which is closely related to hyper-pigmentation. (4-Methoxy-benzylidene)-(3-methoxy-phenyl)-amine, a nitrogen analog of stilbene, was synthesized by a single step process. This compound inhibited the tyrosinase activity, which converts dopa to dopachrome in the biosynthetic process of melanin, and showed a UV-blocking effect at UV-B band. The compound also exhibited SOD-like activity, which is involved in the protection against auto-oxidation and inhibited melanin production in melan-a cell line. Our results suggest the possibility that (4-methoxy-benzylidene)-(3-methoxy-phenyl)-amine might be used as a skin whitening agent.
Choi
Sang Yoon
SY
Graduate School of East-West Medical Science, Kyung Hee University, Seoul, Korea.
Kim
Sanghee
S
Kim
Hocheol
H
Suk
Kyoungho
K
Hwang
Jae Sung
JS
Lee
Byeong Gon
BG
Kim
Ae-Jung
AJ
Kim
Sun Yeou
SY
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051379:Mice; D008810:Mice, Inbred C57BL; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D012880:Skin Pigmentation / Q000187:drug effects; D013267:Stilbenes / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D013473:Sunscreening Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides / Q000037:antagonists & inhibitors; D014466:Ultraviolet Rays
C467586:(4-Methoxy-benzylidene)-(3-methoxy-phenyl)-amine; D008543:Melanins; D013267:Stilbenes; D013473:Sunscreening Agents; D013481:Superoxides; D014442:Monophenol Monooxygenase; D013482:Superoxide Dismutase