title: Bilateral motor cortex output with intended unimanual contraction in congenital mirror movements.
abstract: In congenital mirror movements (MM), it is unclear whether the "mirror" motor cortex (M1) produces output during intended unimanual movements. In two patients with MM, the cortical silent period (CSP) was abnormally short after focal transcranial magnetic stimulation (TMS) of either M1, but simultaneous bilateral TMS led to significant CSP lengthening. Thus, it is likely that the shortened CSP after unilateral TMS is caused by output from the nonstimulated M1, suggesting that both M1 produce output with intended unimanual movements in patients with MM.
authors.affiliation: Unit of Neurology, Santa Maria Nuova Hospital, Florence, Italy. cincotta@unifi.it
authors.forename: M
authors.initials: M
authors.lastname: Cincotta
authors.forename: A
authors.initials: A
authors.lastname: Borgheresi
authors.forename: P
authors.initials: P
authors.lastname: Boffi
authors.forename: P
authors.initials: P
authors.lastname: Vigliano
authors.forename: A
authors.initials: A
authors.lastname: Ragazzoni
authors.forename: G
authors.initials: G
authors.lastname: Zaccara
authors.forename: U
authors.initials: U
authors.lastname: Ziemann
mesh_terms: D000293:Adolescent; D000328:Adult; D004574:Electromagnetic Fields; D004576:Electromyography; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D009044:Motor Cortex / Q000502:physiology*; D009069:Movement Disorders / Q000151:congenital* / Q000503:physiopathology*; D009119:Muscle Contraction / Q000502:physiology