Determination of regional blood volume and intra-extracapillary water exchange in human myocardium using Feruglose: First clinical results in patients with coronary artery disease.
The aim of this pilot study in humans was to investigate the effect of an intravascular contrast agent (CA) on relaxation rate in myocardium (R(1,myo)) in the steady state. The dependence of R(1,myo) on R(1,blood) was characterized and compared with a theoretical model which allowed determination of the intra- extracapillary water proton exchange frequency (f = 0.48 s(-1)) and the intracapillary blood volume (RBV = 12.9 %). A linear response range of DeltaR(1,myo) on DeltaR(1,blood) was estimated which in future studies will allow the determination of RBV with intravascular CA.
Wacker
Christian M
CM
Department of Cardiology, University of Wuerzburg, Wuerzburg, Germany. c.wacker@medizin.uni-wuerzburg.de
Wiesmann
Frank
F
Bock
Michael
M
Jakob
Peter
P
Sandstede
Jörn J W
JJ
Lehning
Anja
A
Ertl
Georg
G
Schad
Lothar R
LR
Haase
Axel
A
Bauer
Wolfgang R
WR
D000368:Aged; D002196:Capillaries / Q000502:physiology*; D003287:Contrast Media; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000378:metabolism* / Q000503:physiopathology*; D003911:Dextrans; D005260:Female; D052203:Ferrosoferric Oxide; D006801:Humans; D007501:Iron; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010087:Oxides; D012039:Regional Blood Flow / Q000502:physiology; D014867:Water / Q000378:metabolism
D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D014867:Water; D007501:Iron; D052203:Ferrosoferric Oxide