An organic psychosis due to a venlafaxine-propafenone interaction.
OBJECTIVE
An extraordinary case of an organic psychosis during the treatment of a patient with a bipolar affective disorder.


METHODS
Clinical observation and further investigations including monitoring of serum levels (case report).


RESULTS
A significant interaction between venlafaxine and propafenone causes markedly increased serum levels of venlafaxine correlating with unexpected psychopathological changes.


CONCLUSIONS
There is a potentially dangerous interaction between venlafaxine and propafenone. Serum levels of venlafaxine should be monitored if propafenone is added.
Pfeffer
F
F
Klinik für Psychiatrie und Psychotherapie der Städtischen Kliniken a M-Höchst, Frankfurt, Germany.
Grube
M
M
D000368:Aged; D001714:Bipolar Disorder / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D003511:Cyclohexanols / Q000009:adverse effects* / Q000097:blood; D004347:Drug Interactions; D005260:Female; D006801:Humans; D011405:Propafenone / Q000009:adverse effects*; D011618:Psychotic Disorders / Q000209:etiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D013997:Time Factors; D000069470:Venlafaxine Hydrochloride
D003511:Cyclohexanols; D011405:Propafenone; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride