title: Indoor risk factors for asthma in a prospective study of adolescents.
abstract: BACKGROUND
  The risk of asthma associated with pets and other indoor exposures has been examined in both cross-sectional and prospective studies of younger children. However, there has been little investigation of the effect of the indoor environment on incident asthma in adolescents.
  
  
  METHODS
  Risk factors for the development of asthma were examined in a cohort of 3535 Southern California school children with no history of asthma at 1993 entry into the study, who were followed for up to 5 years. Newly diagnosed cases of asthma were identified by yearly interview report. A total of 265 children reported a new diagnosis of asthma during the follow-up period; 163 of these had reported no history of wheeze at baseline. The risk associated with indoor exposures assessed by questionnaire at entry into the study was examined using Cox proportional hazards models.
  
  
  RESULTS
  In children with no history of wheezing, an increased risk of developing asthma was associated with a humidifier (relative risk [RR] = 1.7; 95% confidence interval [CI] = 1.2-2.4), any pet (RR = 1.6; 95% CI = 1.0-2.5), or specifically a dog (RR = 1.4; 95% CI = 1.0-2.0) in the home. An estimated 32% of new asthma cases could be attributed to pets.
  
  
  CONCLUSIONS
  We conclude that furry pets are a common and potentially remediable risk factor for new onset asthma in adolescents. Our results suggest that a humidifier in the home may contribute to the onset of asthma in this age group.
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA. rmcconne@hsc.usc.edu
authors.forename: Rob
authors.initials: R
authors.lastname: McConnell
authors.forename: Kiros
authors.initials: K
authors.lastname: Berhane
authors.forename: Frank
authors.initials: F
authors.lastname: Gilliland
authors.forename: Talat
authors.initials: T
authors.lastname: Islam
authors.forename: W James
authors.initials: WJ
authors.lastname: Gauderman
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: London
authors.forename: Edward
authors.initials: E
authors.lastname: Avol
authors.forename: Edward B
authors.initials: EB
authors.lastname: Rappaport
authors.forename: Helene G
authors.initials: HG
authors.lastname: Margolis
authors.forename: John M
authors.initials: JM
authors.lastname: Peters
mesh_terms: D000293:Adolescent; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D000485:Allergens; D000818:Animals; D000829:Animals, Domestic; D001249:Asthma / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D002140:California / Q000453:epidemiology; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006813:Humidity / Q000009:adverse effects*; D008297:Male; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012135:Respiratory Sounds / Q000209:etiology
chemical_list: D000485:Allergens