title: Silyl-substituted amino acids: new routes to the construction of selectively functionalized peptidomimetics.
abstract: [reaction: see text]. Silylated amino acids have been incorporated into peptides and then converted into N-acyliminium ions with the use of an anodic oxidation reaction. The result is a method for selectively incorporating conformational constraints or external nucleophiles within the peptide.
authors.affiliation: Department of Chemistry, Washington University, St. Louis, Missouri 63130, USA.
authors.forename: Haizhou
authors.initials: H
authors.lastname: Sun
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Moeller
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D003500:Cyclization; D007202:Indicators and Reagents; D007769:Lactams / Q000138:chemical synthesis; D018716:Molecular Mimicry; D010084:Oxidation-Reduction; D010455:Peptides / Q000138:chemical synthesis*; D017655:Silicon Compounds / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D007202:Indicators and Reagents; D007769:Lactams; D010455:Peptides; D017655:Silicon Compounds