[The Brugada syndrome].
On the case of a patient who had medical care on account of a febrile disease diagnosed as pleuritis the authors draw attention to a relatively new pathological unit described as the "Brugada syndrome". It is a genetically conditioned anomaly of sodium channels, which, when fully expressed, is manifested by a picture resembling right bundle branch block, elevation of ST segment in leads V1-V3 and the occurrence of malignant ventricular arrhythmias or sudden death without structural heart disease. Neither the reported patient nor his family suffered from arrhythmias. The authors present however a typical electrocardiographic picture ad positive test with ajmaline, a substance which by blocking sodium channels can frequently induce latent and variable changes.
Mádle
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II. interní klinika LF UK Plzen a Fakultní nemocnice, Plzen.
Kratochvíl
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Polívková
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D002037:Bundle-Branch Block / Q000175:diagnosis*; D016757:Death, Sudden, Cardiac; D004562:Electrocardiography; D005334:Fever; D006801:Humans; D008297:Male; D008875:Middle Aged; D015222:Sodium Channels / Q000235:genetics* / Q000378:metabolism; D013577:Syndrome
D015222:Sodium Channels