The influence of cisplatinum and goserelinum on the magnesium and calcium level in rat serum.
The influence of cisplatinum and goserelinum on the magnesium and calcium concentration in rat serum has been studied. The cisplatinum induces decrease in serum magnesium concentration (to 70%), and calcium concentration (to 63%). Goserelinum activity was similar to cisplatinum activity. The magnesium concentration decreased to 60%, and calcium to 44%. In condition of cisplatinum and goserelinum activity the hypomagnesemia and hypocalcemia were noted.
Klukowska
L
L
Department of Human Physiology, Medical University of Lublin.
Nadulska
A
A
Dyba
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002118:Calcium / Q000097:blood*; D002945:Cisplatin / Q000494:pharmacology*; D017273:Goserelin / Q000494:pharmacology*; D006996:Hypocalcemia / Q000139:chemically induced; D008274:Magnesium / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D017273:Goserelin; D008274:Magnesium; D002945:Cisplatin; D002118:Calcium