title: Outcome of endoscopic sphincterotomy in post cholecystectomy patients with sphincter of Oddi dysfunction as predicted by manometry and quantitative choledochoscintigraphy.
abstract: BACKGROUND
  Sphincter of Oddi dysfunction is diagnosed at manometry and, after cholecystectomy, non-invasively at quantitative choledochoscintigraphy. Patients may benefit from endoscopic sphincterotomy.
  
  
  OBJECTIVE
  The aim of this study was to assess the usefulness of choledochoscintigraphy compared with manometry in predicting outcome of sphincterotomy in post cholecystectomy patients with sphincter of Oddi dysfunction.
  
  
  METHODS
  Thirty patients with biliary-type pain complying with the Rome diagnostic criteria of sphincter of Oddi dysfunction and belonging to biliary group I and II were subjected to clinical evaluation, choledochoscintigraphic assessment of the hepatic hilum-duodenum transit time, endoscopic retrograde cholangiopancreatography, and perendoscopic manometry. Twenty two biliary group I and II patients with prolonged hepatic hilum-duodenum transit times were invited to undergo sphincterotomy. Fourteen patients underwent sphincterotomy; eight refused. Clinical and scintigraphic assessments were performed at follow up.
  
  
  RESULTS
  Hepatic hilum-duodenum transit time was delayed in all patients with manometric evidence of sphincter of Oddi dysfunction, in all biliary group I patients and in 64% of biliary group II patients. At follow up, all patients who underwent sphincterotomy were symptom free and hepatic hilum-duodenum transit time had either normalised or significantly improved. A favourable post sphincterotomy outcome was predicted in 93% of cases at choledochoscintigraphy and in 57% at manometry.
  
  
  CONCLUSIONS
  Quantitative choledochoscintigraphy is a useful and non-invasive test to diagnose sphincter of Oddi dysfunction as well as a reliable predictor of sphincterotomy outcome in post cholecystectomy biliary group I and II patients, irrespective of clinical classification and manometric findings.
authors.affiliation: DPT Gastroenterologia, Università Campus Bio-Medico Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cicala
authors.forename: F I
authors.initials: FI
authors.lastname: Habib
authors.forename: P
authors.initials: P
authors.lastname: Vavassori
authors.forename: N
authors.initials: N
authors.lastname: Pallotta
authors.forename: O
authors.initials: O
authors.lastname: Schillaci
authors.forename: G
authors.initials: G
authors.lastname: Costamagna
authors.forename: M P L
authors.initials: MP
authors.lastname: Guarino
authors.forename: F
authors.initials: F
authors.lastname: Scopinaro
authors.forename: F
authors.initials: F
authors.lastname: Fiocca
authors.forename: A
authors.initials: A
authors.lastname: Torsoli
authors.forename: E
authors.initials: E
authors.lastname: Corazziari
mesh_terms: D000328:Adult; D000368:Aged; D001646:Bile / Q000378:metabolism; D002763:Cholecystectomy / Q000009:adverse effects*; D003137:Common Bile Duct Diseases / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011379:Prognosis; D011877:Radionuclide Imaging; D009803:Sphincter of Oddi / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D016717:Sphincterotomy, Endoscopic; D019780:Technetium Tc 99m Lidofenin; D016896:Treatment Outcome
chemical_list: D019780:Technetium Tc 99m Lidofenin