title: No major schizophrenia locus detected on chromosome 1q in a large multicenter sample.
abstract: Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.
authors.affiliation: Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA. dfl@mail.med.upenn.edu
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Levinson
authors.forename: Peter A
authors.initials: PA
authors.lastname: Holmans
authors.forename: Claudine
authors.initials: C
authors.lastname: Laurent
authors.forename: Brien
authors.initials: B
authors.lastname: Riley
authors.forename: Ann E
authors.initials: AE
authors.lastname: Pulver
authors.forename: Pablo V
authors.initials: PV
authors.lastname: Gejman
authors.forename: Sibylle G
authors.initials: SG
authors.lastname: Schwab
authors.forename: Nigel M
authors.initials: NM
authors.lastname: Williams
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
authors.forename: Dieter B
authors.initials: DB
authors.lastname: Wildenauer
authors.forename: Alan R
authors.initials: AR
authors.lastname: Sanders
authors.forename: Gerald
authors.initials: G
authors.lastname: Nestadt
authors.forename: Bryan J
authors.initials: BJ
authors.lastname: Mowry
authors.forename: Brandon
authors.initials: B
authors.lastname: Wormley
authors.forename: Stephanie
authors.initials: S
authors.lastname: Bauché
authors.forename: Stephane
authors.initials: S
authors.lastname: Soubigou
authors.forename: Robert
authors.initials: R
authors.lastname: Ribble
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Nertney
authors.forename: Kung Yee
authors.initials: KY
authors.lastname: Liang
authors.forename: Laura
authors.initials: L
authors.lastname: Martinolich
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Nadine
authors.initials: N
authors.lastname: Norton
authors.forename: Hywel
authors.initials: H
authors.lastname: Williams
authors.forename: Margot
authors.initials: M
authors.lastname: Albus
authors.forename: Eric B
authors.initials: EB
authors.lastname: Carpenter
authors.forename: Nicola
authors.initials: N
authors.lastname: DeMarchi
authors.forename: Kelly R
authors.initials: KR
authors.lastname: Ewen-White
authors.forename: Dermot
authors.initials: D
authors.lastname: Walsh
authors.forename: Maurice
authors.initials: M
authors.lastname: Jay
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Deleuze
authors.forename: F Anthony
authors.initials: FA
authors.lastname: O'Neill
authors.forename: George
authors.initials: G
authors.lastname: Papadimitriou
authors.forename: Ann
authors.initials: A
authors.lastname: Weilbaecher
authors.forename: Bernard
authors.initials: B
authors.lastname: Lerer
authors.forename: Michael C
authors.initials: MC
authors.lastname: O'Donovan
authors.forename: Dimitris
authors.initials: D
authors.lastname: Dikeos
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Silverman
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Kendler
authors.forename: Jacques
authors.initials: J
authors.lastname: Mallet
authors.forename: Raymond R
authors.initials: RR
authors.lastname: Crowe
authors.forename: Marilyn
authors.initials: M
authors.lastname: Walters
mesh_terms: D000349:Africa; D000483:Alleles; D001315:Australia; D002170:Canada; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D005060:Europe; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D014481:United States