title: Synthesis and turnover of folates in plants.
abstract: Folates are essential cofactors for one-carbon transfer reactions, which are central to plant metabolism. Plants synthesize folates de novo, and are key sources of dietary folate for humans. Research into plant folates therefore impacts human nutrition. Biochemical progress, the sequencing of the Arabidopsis genome, and EST databases are now painting a clear picture of the folate synthesis pathway in plants and its surprising compartmentation. Moreover, new analytical advances will help to elucidate plant folate turnover and transport, which are practically unexplored.
authors.affiliation: Horticultural Sciences Department, University of Florida, Gainesville, Florida 32611, USA. adha@mail.ifas.ufl.edu
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hanson
authors.forename: Jesse F
authors.initials: JF
authors.lastname: Gregory
mesh_terms: D010129:4-Aminobenzoic Acid / Q000378:metabolism; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D001692:Biological Transport; D019731:Carbon-Nitrogen Ligases; D004798:Enzymes / Q000235:genetics / Q000378:metabolism; D005492:Folic Acid / Q000378:metabolism*; D006136:GTP Cyclohydrolase / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D011621:Pteridines / Q000378:metabolism; D013763:Tetrahydrofolates / Q000737:chemistry / Q000378:metabolism*; D000637:Transaminases / Q000378:metabolism
chemical_list: D004798:Enzymes; D011621:Pteridines; D013763:Tetrahydrofolates; D018698:Glutamic Acid; C030371:5,6,7,8-tetrahydrofolic acid; D005492:Folic Acid; D000637:Transaminases; C066599:aminodeoxychorismate synthase; D006136:GTP Cyclohydrolase; D019731:Carbon-Nitrogen Ligases; D010129:4-Aminobenzoic Acid