[Effects of microinjection of amino acids into pre-Bötzinger complex on respiration in adult rats].
Experiments were performed on sodium pentobarbital anesthetized and bilaterally vagotomized adult SD rats. Microinjection of an excitatory neurotoxin, kainic acid, into pre-Bötzinger complex initially lengthened the duration of inspiration, shortened the duration of expiration and increased the respiratory frequency, and subsequently abolished rhythmic respiration. Injection of an excitatory amino acid, L-glutamate, shortened the duration of expiration. Injection of the inhibitory amino acids (either glycine or gamma-aminobutyric acid) shortened the duration of inspiration. These results suggest that the pre-Bötzinger complex in adult rats plays an important role in neurogenesis and maintenance of rhythmic respiration.
Li
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C
Department of Physiology, West China University of Medical Sciences, Chengdu 610041, China. chuan_li99@hotmail.com
Yu
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W
Zheng
Y
Y
D000818:Animals; D018683:Excitatory Amino Acid Agents / Q000494:pharmacology*; D005260:Female; D018698:Glutamic Acid / Q000494:pharmacology; D005998:Glycine / Q000494:pharmacology; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D008845:Microinjections; D051381:Rats; D017207:Rats, Sprague-Dawley; D012119:Respiration; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D018683:Excitatory Amino Acid Agents; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D005998:Glycine