title: The influences of maternal albumin concentrations on the placental transfer of propofol in human dually perfused cotyledon in vitro.
abstract: These results indicate that fetal exposure to propofol can vary considerably depending on maternal plasma albumin concentration. A fractional change in the maternal protein binding of propofol can result in a relatively large difference in fetal exposure.
authors.affiliation: Department of Anesthesiology, Hyogo College of Medicine, Nishinomiya City, Japan. Yhe@partners.org
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: He
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Seno
authors.forename: Ken
authors.initials: K
authors.lastname: Sasaki
authors.forename: Chikara
authors.initials: C
authors.lastname: Tashiro
mesh_terms: D018686:Anesthetics, Intravenous / Q000493:pharmacokinetics*; D001692:Biological Transport; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D010477:Perfusion; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D015742:Propofol / Q000493:pharmacokinetics*; D012709:Serum Albumin / Q000032:analysis*
chemical_list: D018686:Anesthetics, Intravenous; D012709:Serum Albumin; D015742:Propofol