title: A developmental and neurobiological approach to early trauma research.
abstract: Basic and clinical research documents associations between stress and a set of related psychobiologic perturbations, including dysfunction of the hypothalamic-pituitary-adrenal axis, alterations in the structure and function of the medial temporal lobe, and impairments in explicit memory. Although these associations are thought to emerge developmentally, insufficient clinical research elucidates the manner in which early trauma relates to these abnormalities. To gain a better understanding of relevant processes, we propose the use of a developmental and neurobiological approach, where data in animal models are used to inform studies in traumatized children who will be followed longitudinally. This approach will help clarify how early traumatic events have the capacity to lead to psychopathology or a healthy outcome.
authors.affiliation: Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA. christopher.monk@nih.gov
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Monk
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Pine
authors.forename: Dennis S
authors.initials: DS
authors.lastname: Charney
mesh_terms: D000328:Adult; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D001921:Brain / Q000002:abnormalities / Q000187:drug effects; D002648:Child; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology*; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology*
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone