title: Quality of life in osteogenesis imperfecta.
abstract: The purpose of this study was to quantify the physical and mental health of a diverse adult cohort of patients with osteogenesis imperfecta (OI) utilizing a validated health self-assessment questionnaire (SF-36). In addition, a specific demographic questionnaire and a functional questionnaire were utilized to assess more specifically the physical limitations imposed by osteogenesis imperfecta in adulthood. The results of the SF-36 revealed significantly lower physical function scores compared to the U.S. adult norms. However, the SF-36 mental component scores were equal to the U.S. adult norms. The demographic questionnaire revealed high levels of educational achievement, as well as employment, despite significant physical impairments. The functional questionnaire clearly demonstrated limitations mostly related to ambulation.
authors.affiliation: Pediatric Orthopaedics, Hospital for Special Surgery, New York, NY 10021, USA. Widmannr@hss.edu
authors.forename: Roger F
authors.initials: RF
authors.lastname: Widmann
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Laplaza
authors.forename: Fabien D
authors.initials: FD
authors.lastname: Bitan
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Brooks
authors.forename: Leon
authors.initials: L
authors.lastname: Root
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010013:Osteogenesis Imperfecta / Q000503:physiopathology* / Q000523:psychology*; D011788:Quality of Life; D012647:Self-Assessment; D011795:Surveys and Questionnaires