title: The role of interleukin-10 in critical illness.
abstract: Interleukin-10 is the most potent anti-inflammatory cytokine yet identified. It has multiple actions affecting the innate immune system as well as humoral and cellular immune responses. It occupies a pivotal role in the regulation of the immune response to microbial pathogens in health and disease. Knowledge gained in the molecular biology of IL-10 and its complex immune effects in experimental infection models are leading to new insights into therapeutic manipulation of IL-10 in patients with systemic inflammatory diseases.
authors.affiliation: Infectious Disease Division, Brown University School of Medicine, Providence, Rhode Island, USA.
authors.forename: Steven M.
authors.initials: SM
authors.lastname: Opal
authors.forename: Christian E.
authors.initials: CE
authors.lastname: Huber