title: Effects of sertraline treatment on plasma cortisol, prolactin and thyroid hormones in female depressed patients.
abstract: The aim of the study was to evaluate the effects of 4 and 24 weeks of sertraline treatment (average dose 42.5 mg/day) on plasma hormone levels in 15 female patients with major depression. Baseline levels of triiodothyronine (T(3)) were lower, while cortisol, prolactin (PRL), thyroid-stimulating hormone (TSH), and thyroxin (T(4)) levels did not differ from the values in 16 female controls. There was a positive correlation between the scores on the Montgomery-Asperg Depression Rating Scale and baseline cortisol levels. Treatment with sertraline for 4 weeks increased plasma cortisol levels, while 24 weeks of sertraline treatment increased plasma T(3) levels in depressed patients. Neither 4, nor 24 weeks of sertraline treatment affected PRL, T(4) and TSH levels in depressed patients. The data show different and time-dependent effects of sertraline treatment on plasma cortisol, PRL and thyroid hormones in female depressed patients.
authors.affiliation: University Hospital Center Zagreb, Department of Psychiatry, Zagreb, Croatia.
authors.forename: Marina
authors.initials: M
authors.lastname: Sagud
authors.forename: Nela
authors.initials: N
authors.lastname: Pivac
authors.forename: Dorotea
authors.initials: D
authors.lastname: Mück-Seler
authors.forename: Miro
authors.initials: M
authors.lastname: Jakovljević
authors.forename: Alma
authors.initials: A
authors.lastname: Mihaljević-Peles
authors.forename: Mirko
authors.initials: M
authors.lastname: Korsić
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D020280:Sertraline / Q000494:pharmacology* / Q000627:therapeutic use; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood / Q000187:drug effects; D014284:Triiodothyronine / Q000097:blood / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D006854:Hydrocortisone; D011388:Prolactin; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline; D013963:Thyroid Hormones; D013972:Thyrotropin; D013974:Thyroxine; D014284:Triiodothyronine