Schwann cell caveolin-1 expression increases during myelination and decreases after axotomy.
The caveolins are a family of related proteins that form the structural framework of caveolae. They have been implicated in the regulation of signal transduction, cell cycle control, and cellular transport processes, particularly cholesterol trafficking. Caveolin-1 is expressed by a variety of cell types, including Schwann cells, although its expression is greatest in differentiated cell types, such as endothelial cells and adipocytes. In the present work, we characterize caveolin-1 expression both during rat sciatic nerve development and after axotomy. Schwann cells express little caveolin-1 on postnatal days 1 and 6. By P30, myelinating Schwann cells express caveolin-1, which is localized in the outer/abaxonal myelin membranes as well as intracellularly. After axotomy, Schwann cell caveolin-1 expression in the distal nerve stump decreases as Schwann cells revert to a premyelinating (p75-positive) phenotype; residual caveolin-1 within the nerve largely localizes to myelin debris and infiltrating macrophages. We speculate that caveolin-1 plays a role in the biology of myelinating Schwann cells.
Mikol
Daniel D
DD
Department of Neurology, University of Michigan, Ann Arbor 48109, USA. dmiko@umich.edu
Scherer
Steven S
SS
Duckett
Sara J
SJ
Hong
Hoylond L
HL
Feldman
Eva L
EL
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D019771:Axotomy; D051242:Caveolin 1; D022461:Caveolins / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology*; D009186:Myelin Sheath / Q000378:metabolism*; D018992:Myelin-Associated Glycoprotein / Q000378:metabolism; D009410:Nerve Degeneration / Q000378:metabolism / Q000503:physiopathology; D009416:Nerve Regeneration / Q000502:physiology*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism; D012583:Schwann Cells / Q000166:cytology / Q000378:metabolism*; D012584:Sciatic Nerve / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism
C495537:Cav1 protein, rat; D051242:Caveolin 1; D022461:Caveolins; D018992:Myelin-Associated Glycoprotein; D020033:Protein Isoforms; D012333:RNA, Messenger; D020800:Receptor, Nerve Growth Factor