Selectins: critical mediators of leukocyte recruitment.
Selectins are multi-functional adhesion molecules that mediate the initial interactions between circulating leukocytes and the endothelium. First identified over a decade ago, selectins have provided insight into areas as diverse as normal lymphocyte homing, leukocyte recruitment during inflammatory responses, carbohydrate ligand biosynthesis and adhesion-mediated signalling. This review will examine the selectins and their ligands with a focus on recent findings using knockout technology as well as the emerging role of selectins as signalling molecules.
Patel
Kamala D
KD
Department of Physiology and Biophysics, University of Calgary, Alberta, Canada. kpatel@ucalgary.ca
Cuvelier
Susan L
SL
Wiehler
Shahina
S
D000818:Animals; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D004730:Endothelium, Vascular / Q000276:immunology / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000276:immunology* / Q000502:physiology*; D008024:Ligands; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D019087:Selectins / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
D008024:Ligands; D019087:Selectins