title: Flavonoids as chemoprotective agents in civilization diseases.
abstract: Flavonoids, a class of polyphenolic compounds widely distributed in the plant kingdom, are capable of protecting against several chronic and degenerative diseases, among them cancer, cardiovascular diseases, stroke, cataracts and brain and immune dysfunctional states. These substances are common dietary components. They exhibit many biological properties through various mechanism of activity. Early studies of flavonoids investigated their significant antioxidant, antitumor, anti-inflammatory, antiallergenic and hepatoprotective effect. Additionally, their ability to modulate the activity of various enzymes affects normal as well as malignant systems. This review summarizes data on the beneficial effects of flavonoids in humans.
authors.affiliation: Cancer Research Institute, Slovak Academy of Science, Bratislava. exonkata@savba.sk
authors.forename: K
authors.initials: K
authors.lastname: Horváthová
authors.forename: A
authors.initials: A
authors.lastname: Vachálková
authors.forename: L
authors.initials: L
authors.lastname: Novotný
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D004032:Diet; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009153:Mutagens / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism; D016877:Oxidants / Q000737:chemistry / Q000494:pharmacology*; D011315:Preventive Medicine
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D005419:Flavonoids; D009153:Mutagens; D016877:Oxidants; D009569:Nitric Oxide