title: Online genomics facilities in the new millennium.
abstract: The review begins by providing a brief typology of biological databases on the Internet, illustrated by examples of the most influential resources of each kind. We then take an insider look at one typical on-line genomic resource -- the yeast genome database hosted at the Munich Information Center for Protein Sequences (MIPS) -- and explain how and why it has evolved from a basic sequence repository to a multidomain knowledge base. The role of community efforts in curating and annotating genome data is discussed. The crucial role of data integration and interoperability in developing next-generation genomic facilities is underscored.
authors.affiliation: Institute for Bioinformatics, GSF - National Research Center for Environment and Heatlh, Ingolstädter Landstrasse 1, 85764 Neueherberg, Germany. d.frishman@gsf.de
authors.forename: Dmitrij
authors.initials: D
authors.lastname: Frishman
authors.forename: Andreas
authors.initials: A
authors.lastname: Kaps
authors.forename: Hans-Werner
authors.initials: HW
authors.lastname: Mewes
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods / Q000639:trends*; D030541:Databases, Genetic / Q000639:trends*; D023281:Genomics / Q000379:methods / Q000639:trends*; D006801:Humans; D009862:Online Systems / Q000639:trends*