title: Can transcutaneous bilirubinometry reduce the need for blood tests in jaundiced full term babies?
abstract: BACKGROUND
  Previous studies have suggested that transcutaneous bilirubinometry (TcB) may provide a useful method for screening for significant jaundice, thereby reducing unnecessary blood tests. These studies have not allowed an estimation of the magnitude of such a benefit.
  
  
  OBJECTIVE
  To evaluate the accuracy of TcB as a method of determining the need for serum bilirubin (SBR) measurements in full term babies and to quantify the magnitude of any benefit.
  
  
  METHODS
  Babies born at more than 34 weeks gestation who had not previously been exposed to phototherapy and were requiring blood sampling in the first week of life.
  
  
  METHODS
  TcB measurements were made at the same time as blood sampling. SBR was measured in all blood samples. For jaundiced babies, the ability of TcB to detect significant jaundice (SBR > 249 micromol/l) was evaluated.
  
  
  RESULTS
  There was a correlation between SBR and TcB measurements (n = 303, r = 0.76, p < 0.0001), but the 95% prediction interval for SBR from TcB was wide (+/- 88.3 micromol/l). For the 285 jaundiced babies, the area under the receiver operator characteristic curve was 0.89. A TcB value of 18 detected significant jaundice with a sensitivity of 100% and a specificity (95% confidence interval) of 45% (39% to 51%). If blood samples had only been taken from babies with a TcB value greater than 18, the number of samples taken would have been reduced by 34%.
  
  
  CONCLUSIONS
  SBR cannot be measured accurately by TcB. However, TcB measurements can be used to determine the need for blood sampling in jaundiced babies and will reduce the number of blood samples taken. Recent improvements in TcB may improve the performance of this method.
authors.affiliation: Liverpool Womens Hospital, Crown Street, Liverpool L8 7SS, UK.
authors.forename: L
authors.initials: L
authors.lastname: Briscoe
authors.forename: S
authors.initials: S
authors.lastname: Clark
authors.forename: C W
authors.initials: CW
authors.lastname: Yoxall
mesh_terms: D001663:Bilirubin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000175:diagnosis*; D011446:Prospective Studies; D012372:ROC Curve; D012016:Reference Values; D012680:Sensitivity and Specificity; D012867:Skin
chemical_list: D015415:Biomarkers; D001663:Bilirubin