Antigenic variation and allelic exclusion.
Cells often express only one gene from a set of two or more. African trypanosomes appear to accomplish this monoallelic expression by segregating the selected gene into a specific nuclear body. The possibility that such a structure might explain monoallelic expression in other multigene systems is discussed here.
Borst
Piet
P
The Netherlands Cancer Institute, Division of Molecular Biology and Center for Biomedical Genetics, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. p.borst@nki.nl
D022981:Allelic Imbalance / Q000235:genetics*; D000818:Animals; D000940:Antigenic Variation / Q000235:genetics* / Q000276:immunology; D002451:Cell Compartmentation / Q000235:genetics; D022003:Cell Nucleus Structures / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation / Q000235:genetics; D020868:Gene Silencing / Q000276:immunology; D014158:Transcription, Genetic / Q000235:genetics; D014345:Trypanosoma / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000235:genetics / Q000276:immunology
D014643:Variant Surface Glycoproteins, Trypanosoma