Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Oral or intravenous antidote for paracetamol overdose.
A short cut review was carried out to establish whether there was any evidence to decide between oral or intravenous antidote in paracetamol (acetaminophen) poisoning. Altogether 330 papers were found using the reported search, of which two presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated. A clinical bottom line is stated.
Clarke
Simon
S
Herren
Katrina
K
D000082:Acetaminophen / Q000506:poisoning*; D000284:Administration, Oral; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000506:poisoning*; D000931:Antidotes / Q000008:administration & dosage*; D062787:Drug Overdose / Q000628:therapy; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous
D018712:Analgesics, Non-Narcotic; D000931:Antidotes; D000082:Acetaminophen