title: Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein.
abstract: A new triterpene glycoside, 26-deoxyactein (1), along with two known compounds, 23-epi-26-deoxyactein (2), previously designated as "27-deoxyactein", and actein (3), were isolated from the roots/rhizomes of Cimicifuga racemosa. The structures and absolute stereochemistry of 1 and 2 were established by spectroscopic methods (FABMS, (1)H and (13)C NMR) and single-crystal X-ray data analysis.
authors.affiliation: Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS, M/C 877), Department of Medicinal Chemistry, College of Pharmacy, University of Illinois at Chicago, 60612, USA.
authors.forename: Shao-Nong
authors.initials: SN
authors.lastname: Chen
authors.forename: Wenkui
authors.initials: W
authors.lastname: Li
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Fabricant
authors.forename: Bernard D
authors.initials: BD
authors.lastname: Santarsiero
authors.forename: Andrew
authors.initials: A
authors.lastname: Mesecar
authors.forename: John F
authors.initials: JF
authors.lastname: Fitzloff
authors.forename: Harry H S
authors.initials: HH
authors.lastname: Fong
authors.forename: Norman R
authors.initials: NR
authors.lastname: Farnsworth
mesh_terms: D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D029626:Ranunculaceae / Q000737:chemistry* / Q000145:classification; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification; D014768:Virginia
chemical_list: D012503:Saponins; D014315:Triterpenes; C457248:23-epi-26-deoxyactein; C096066:26-deoxyactein