Preliminary study on antifertility activity of Calotropis procera roots in female rats.
The effect of ethanolic extract of the roots of Calotropis procera has been studied in albino rats to explore its antifertility and hormonal activities. A strong antiimplantation (inhibition 100%) and uterotropic activity was observed at the dose level of 250 mg/kg (1/4 of LD(50)). No antiestrogenic activity could be detected.
Kamath
Jagadish V
JV
Department of Pharmacology, Krupanidhi College of Pharmacy, Sarjapur Road, Kormanagala, Bangalore 560 034, India. jvkam@rediffmail.com
Rana
A C
AC
D000284:Administration, Oral; D000818:Animals; D029062:Apocynaceae; D002584:Cervix Uteri / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018517:Plant Roots; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000187:drug effects* / Q000502:physiology; D014621:Vagina / Q000187:drug effects / Q000502:physiology
D010936:Plant Extracts