Description of fourteen new DRB alleles found in a stem cell donor registry.
Fourteen DRB alleles, DRB1*0705, DRB1*11014, DRB1*1134, DRB1*1136, DRB1*1141, DRB1*1335, DRB1*1337, DRB1*1338, DRB1*1342, DRB1*1343, DRB1*1349, DRB1*1510, DRB3*0105, and DRB5*0103, are described. Among them, eleven are variants which differ by only one nucleotide from previously described alleles, including one silent variant (DRB1*11014). Alleles, DRB1*0705, DRB1*1335 and DRB3*0105, display unique sequence motifs that have never been observed in DRB alleles.
Tang
T F
TF
Department of Pediatrics, Georgetown University, Washington, DC, USA.
Lin
Y-S
YS
Robbins
F-M
FM
Li
L
L
Sintasath
D
D
Coquillard
G
G
Huang
A
A
Heine
U
U
Ng
J
J
Hartzman
R J
RJ
Hurley
C K
CK
D000483:Alleles; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains; D059847:HLA-DRB5 Chains; D006801:Humans; D012042:Registries; D017422:Sequence Analysis, DNA; D013234:Stem Cells; D014019:Tissue Donors
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains; D059847:HLA-DRB5 Chains