title: Microsatellite instability in patients with gastric remnant cancer.
abstract: BACKGROUND: About 2% of patients who undergo partial distal gastrectomy for gastroduodenal diseases develop gastric remnant cancer 10 to 30 years after the gastrectomy. It is important in clinical practice to determine a molecular marker to identify patients susceptible to gastric remnant cancer.METHODS: We investigated nine gastric remnant cancers (from nine individuals who had gastrectomies for primary gastric cancer or gastroduodenal ulcer) for microsatellite instability (MSI) at six loci, using the polymerase chain reaction (PCR). A control group of ten patients with sporadic gastric cancers in the upper third of the stomach was also similarly analyzed.RESULTS: MSI was demonstrated in eight of nine cancers from the individuals who had had primary gastric cancer or gastroduodenal ulcer (88.9%) compared with two of ten cancers from the individuals with sporadic gastric cancer in the upper third of the stomach (20%).CONCLUSION: These results suggest that one or more MSI is associated with remnant gastric cancer after gastrectomy.
authors.affiliation: First Department of Surgery, Ryukyu University School of Medicine, Okinawa 903-0215, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakachi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyazato
authors.forename: Hideaki
authors.initials: H
authors.lastname: Shimoji
authors.forename: Shungo
authors.initials: S
authors.lastname: Hiroyasu
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Isa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shiraishi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Muto