title: Interaction between grapefruit juice and praziquantel in humans.
abstract: After a single oral dose of praziquantel with 250 ml of grapefruit juice, the area under the concentration-time curve and the maximum concentration in plasma of praziquantel (Cmax) were significantly increased (Cmax for water treatment, 637.71 +/- 128.5 ng/ml; and Cmax for grapefruit juice treatment, 1,037.65 +/- 305.7 ng/ml, P < 0.05). No statistically significant differences were found in the time to maximum concentration of drug in plasma or elimination half-life.
authors.affiliation: Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico. nnct@hotmail.com
authors.forename: Nelly
authors.initials: N
authors.lastname: Castro
authors.forename: Helgi
authors.initials: H
authors.lastname: Jung
authors.forename: Roberto
authors.initials: R
authors.lastname: Medina
authors.forename: Dinora
authors.initials: D
authors.lastname: González-Esquivel
authors.forename: Mario
authors.initials: M
authors.lastname: Lopez
authors.forename: Julio
authors.initials: J
authors.lastname: Sotelo
mesh_terms: D000328:Adult; D000871:Anthelmintics / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001628:Beverages; D002957:Citrus; D018592:Cross-Over Studies; D018565:Food-Drug Interactions; D006801:Humans; D008297:Male; D011223:Praziquantel / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000871:Anthelmintics; D011223:Praziquantel