title: Combined analysis of the ORCHID and OCAY studies: does eradication of Helicobacter pylori lead to sustained improvement in functional dyspepsia symptoms?
abstract: Currently, one of the most important unresolved questions concerning Helicobacter pylori is whether eradication of the organism leads to a sustained improvement in symptoms in patients diagnosed with functional (non-ulcer) dyspepsia. Recently, two very similar studies, the ORCHID and OCAY studies, have been completed and the combined results of these two multicentre, multinational, randomised, double blind, controlled clinical trials are reviewed.
authors.affiliation: Division of Gastroenterology, Dalhousie University, Queen Elizabeth II Health Sciences Centre, Victoria General Site, Room 928 Centennial Building, 5790 University Avenue, Halifax, Nova Scotia, Canada B3H 2YG, Canada. zanten@is.dal.ca
authors.forename: S J O
authors.initials: SJ
authors.lastname: Veldhuyzen van Zanten
authors.forename: N J
authors.initials: NJ
authors.lastname: Talley
authors.forename: A L
authors.initials: AL
authors.lastname: Blum
authors.forename: E
authors.initials: E
authors.lastname: Bolling-Sternevald
authors.forename: M
authors.initials: M
authors.lastname: Sundin
authors.forename: O
authors.initials: O
authors.lastname: Junghard
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D004311:Double-Blind Method; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004415:Dyspepsia / Q000188:drug therapy / Q000382:microbiology*; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009853:Omeprazole / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D009853:Omeprazole