Etizolam-induced superficial erythema annulare centrifugum.
Erythema annulare centrifugum (EAC) is characterized by slowly enlarging annular erythematous lesions. Although the origin is not clear in most cases, EAC has been associated with infections, medications, and in rare cases, underlying malignancy. We describe a patient who developed annular erythematous lesions after etizolam administration. The eruptions were typical of the superficial form of EAC, both clinically and histopathologically. The lesions disappeared shortly after discontinuation of the medication. Patch testing with etizolam gave positive results. To our knowledge this is the first reported case of etizolam-induced superficial EAC.
Kuroda
K
K
Department of Dermatology, Shimotsuga General Hospital, Tochigi, Japan. krkuro@ceres.ocn.ne.jp
Yabunami
H
H
Hisanaga
Y
Y
D000368:Aged; D003975:Diazepam / Q000009:adverse effects* / Q000031:analogs & derivatives*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004890:Erythema / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D014149:Tranquilizing Agents / Q000009:adverse effects*
D014149:Tranquilizing Agents; C044610:etizolam; D003975:Diazepam