title: [Recent advances in molecular pathogenesis of HIV infection].
abstract: Highly active anti-retroviral therapy (HAART) dramatically improves the prognosis of individuals infected with HIV, and changes the pathophysiology of HIV infection. However, the eradication of HIV has not been achieved by HAART due to presence of reservoir cells. More potent strategy of therapy against HIV is needed for further suppression of the replication and eradication of reservoirs. The recent advances about molecular pathogenesis of HIV infection are reviewed in this paper, that leads to discovery of the new molecular targets of anti-HIV drugs.
authors.affiliation: Institute for Virus Research, Kyoto University.
authors.forename: Masao
authors.initials: M
authors.lastname: Matsuoka
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D015815:Cell Adhesion Molecules; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D037102:Lectins / Q000276:immunology; D037181:Lectins, C-Type; D011533:Proviruses; D011956:Receptors, Cell Surface / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology; D013950:Thymus Gland / Q000821:virology; D016662:Virus Integration; D014779:Virus Replication; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D037102:Lectins; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin