Improving the clinical patency of prosthetic vascular and coronary bypass grafts: the role of seeding and tissue engineering.
In patients requiring coronary or peripheral vascular bypass procedures, autogenous vein is currently the conduit of choice. If this is unavailable, then a prosthetic material is used. Prosthetic graft is liable to fail due to occlusion of the graft. To prevent graft occlusion, seeding of the graft lumen with endothelial cells is undertaken. Recent advances have also looked at developing a completely artificial biological graft engineered from the patient's cells with properties similar to autogenous vessels. This review encompasses the developments in the two principal technologies used in developing hybrid coronary and peripheral vascular bypass grafts, that is, seeding and tissue engineering.
Seifalian
Alexander M
AM
Tissue Engineering Center, University Department of Surgery, Royal Free and University College Medical School, University College London and The Royal Free Hospital, U.K. a.seifalian@rfc.ucl.ac.uk
Tiwari
Alok
A
Hamilton
George
G
Salacinski
Henryk J
HJ
D001807:Blood Vessel Prosthesis; D002448:Cell Adhesion; D004730:Endothelium, Vascular; D006083:Graft Occlusion, Vascular / Q000517:prevention & control*; D006801:Humans; D023822:Tissue Engineering; D014654:Vascular Patency