title: Hemolytic uremic syndrome due to an altered factor H triggered by neonatal pertussis.
abstract: We report on a previously healthy newborn suffering from severe Bordetella pertussis infection who developed hemolytic uremic syndrome (HUS) a few weeks after the onset of whooping cough, with a fatal outcome. A factor H protein with abnormal mobility was found in the serum of the patient as analyzed by Western blotting, indicating that B. pertussis infection might have triggered HUS in a genetically predisposed patient.
authors.affiliation: University Children's Hospital, Mathildenstrasse 1, 79106 Freiburg, Germany. berner@kikli.ukl.uni-freiburg.de
authors.forename: Reinhard
authors.initials: R
authors.lastname: Berner
authors.forename: Martin F
authors.initials: MF
authors.lastname: Krause
authors.forename: Nader
authors.initials: N
authors.lastname: Gordjani
authors.forename: Peter F
authors.initials: PF
authors.lastname: Zipfel
authors.forename: Norbert
authors.initials: N
authors.lastname: Boehm
authors.forename: Marcus
authors.initials: M
authors.lastname: Krueger
authors.forename: Matthias
authors.initials: M
authors.lastname: Brandis
authors.forename: Lothar B
authors.initials: LB
authors.lastname: Zimmerhackl
mesh_terms: D001886:Bordetella pertussis; D017242:Complement Factor H / Q000378:metabolism*; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D014917:Whooping Cough / Q000150:complications* / Q000276:immunology
chemical_list: C493495:CFH protein, human; D017242:Complement Factor H