title: [A case of hepatocellular carcinoma with portal tumor thrombus effectively treated by arterial infusion chemotherapy with low-dose cisplatin and 5-fluorouracil].
abstract: A 69-year-old female with unresectable hepatocellular carcinoma was treated with continuous arterial infusion of low-dose cisplatin (10 mg/body/day) and 5-fluorouracil (250 mg/body/day). The regimen was continued for 5 days then discontinued for 2 days, and repeated for 4 weeks. The portal tumor thrombus almost disappeared and HCC was smaller than before chemotherapy. Tumor marker (AFP and PIVKA-II) decreased remarkably. As tumor markers increased again 2 months later, the same regimen chemotherapy was performed once more. The patient was treated with arterial chemotherapy as an outpatient. The present case of hepatocellular carcinoma with portal tumor thrombus was effectively treated by arterial infusion chemotherapy with low dose cisplatin and 5-fluorouracil.
authors.affiliation: 1st. Dept. of Surgery, Toho University School of Medicine.
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Nakazaki
authors.forename: Wataru
authors.initials: W
authors.lastname: Takita
authors.forename: Masashi
authors.initials: M
authors.lastname: Watanabe
authors.forename: Yukitake
authors.initials: Y
authors.lastname: Hasebe
authors.forename: Natuki
authors.initials: N
authors.lastname: Tokura
authors.forename: Akira
authors.initials: A
authors.lastname: Seo
authors.forename: Akiharu
authors.initials: A
authors.lastname: Kurihara
authors.forename: Masashi
authors.initials: M
authors.lastname: Takada
authors.forename: Naoyasu
authors.initials: N
authors.lastname: Saito
authors.forename: Kentaro
authors.initials: K
authors.lastname: Shirasaka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Keihachirou
authors.initials: K
authors.lastname: Hirano
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy*; D009360:Neoplastic Cells, Circulating / Q000187:drug effects*; D011168:Portal System / Q000473:pathology*
chemical_list: D002945:Cisplatin; D005472:Fluorouracil