GABAergic pretectal terminals contact GABAergic interneurons in the cat dorsal lateral geniculate nucleus.
Anterograde tracing techniques combined with postembedding immunocytochemical staining were used to determine the gamma amino butyric acid (GABA) content of pretectogeniculate (PT-LGN) terminals and their postsynaptic targets. The results provide evidence that PT-LGN terminals are GABAergic and that they contact GABAergic interneurons. These results corroborate previous anatomical studies and support the idea that the PT-LGN projection functions to disinhibit thalamocortical cells in the dorsal lateral geniculate nucleus.
Wang
Siting
S
Department of Anatomical Sciences and Neurobiology, University of Louisville, School of Medicine, 500 S. Preston Street, Louisville, KY 40292, USA.
Eisenback
Michael
M
Datskovskaia
Aygul
A
Boyce
Martin
M
Bickford
Martha E
ME
D000818:Animals; D002415:Cats; D005260:Female; D005829:Geniculate Bodies / Q000502:physiology / Q000648:ultrastructure*; D007395:Interneurons / Q000502:physiology / Q000648:ultrastructure*; D009475:Neurons, Afferent / Q000737:chemistry / Q000502:physiology; D017729:Presynaptic Terminals / Q000502:physiology / Q000648:ultrastructure*; D013477:Superior Colliculi / Q000502:physiology / Q000648:ultrastructure*; D014795:Visual Pathways / Q000502:physiology / Q000648:ultrastructure; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D005680:gamma-Aminobutyric Acid