title: Benzimidazole-4,7-diones as inhibitors of protozoal (Toxoplasma gondii) purine nucleoside phosphorylase.
abstract: Benzimidazole-4,7-diones derivatives substituted at 1- and/or 2-position have been synthetized and tested as inhibitors of purine nucleoside phosphorylase (PNP), isolated from two strains of Toxoplasma gondii (RH and ME 49). They were identified as inhibitors of both enzymes.
authors.affiliation: Laboratoire de Chimie Organique (EA 635), Faculté de Pharmacie, Université Lyon I, 8, Avenue Rockefeller, 69373 Lyon Cedex 08, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Alvarez
authors.forename: Arnaud
authors.initials: A
authors.lastname: Ghérardi
authors.forename: Pascal
authors.initials: P
authors.lastname: Nebois
authors.forename: Marie Elizabeth
authors.initials: ME
authors.lastname: Sarciron
authors.forename: Anne Françoise
authors.initials: AF
authors.lastname: Pétavy
authors.forename: Nadia
authors.initials: N
authors.lastname: Walchshofer
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014122:Toxoplasma / Q000201:enzymology*
chemical_list: D000981:Antiprotozoal Agents; D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D011683:Purine-Nucleoside Phosphorylase