title: [Proliferating activity and differentiation between peripheral cells and central cells in ameloblastoma].
abstract: OBJECTIVE
  To investigate the proliferating activities and differentiation between peripheral cells and central cells in ameloblastoma.
  
  
  METHODS
  Expressions of proliferating cell nuclear antigen (PCNA), Ki-67, CK10&13 and CK19 were detected in 43 ameloblastoma (15 follicular, 20 plexiform and 8 acanthomatous) by SP immunohistochemical methods.
  
  
  RESULTS
  The PCNA labelling indices were significantly higher in peripheral cells (5.12% +/- 2.76%) of tumour nests or strands than in central cells (1.36% +/- 1.02%, P < 0.001). The peripheral cells of tumour nests or strands exhibited a significantly higher Ki-67 labelling index (3.63% +/- 1.80%) than central cells (1.26% +/- 0.96%, P < 0.001). The labelling indices between PCNA and Ki-67 showed a significant correlation (P < 0.01). The positive expressions of CK10&13 and CK19 were significantly higher in central cells than in peripheral cells (P < 0.01).
  
  
  CONCLUSIONS
  The peripheral zones of tumour nests or strands are regarded as proliferating areas; there exists a significantly different differentiation between central cells and peripheral cells.
authors.affiliation: Department of Oral Pathology, College of Stomatology, Wuhan University, Wuhan 430079, China.
authors.forename: Jinzhong
authors.initials: J
authors.lastname: Liu
authors.forename: Shuozhi
authors.initials: S
authors.lastname: Wang
authors.forename: Xinming
authors.initials: X
authors.lastname: Chen
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000564:Ameloblastoma / Q000737:chemistry / Q000473:pathology*; D002454:Cell Differentiation; D002455:Cell Division; D002648:Child; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000737:chemistry / Q000473:pathology*; D007633:Keratins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis
chemical_list: D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen; D007633:Keratins