title: Synthesis, characterization and antiamoebic activity of benzimidazole derivatives and their vanadium and molybdenum complexes.
abstract: Reaction of [MoO(2)(acac)(2)] (where, acac=acetyl acetone) and KVO(3) with 2-(salicylidieneimine) benzimidazole lead to form new complexes [MoO(2)(sal-BMZ)(2)] and K [VO(2)(sal-BMZ)(2)] [where, sal-BMZ=2-(salicylidieneimine) benzimidazole], which showed the monobasic bidentate nature of the ligand in which the phenolic oxygen and the imine nitrogen of the ligand are coordinated to the metal ion. These complexes were characterized along with nine other complexes of oxoperoxovanadium (V), molybdenum (Vl) and tungsten (Vl) with benzimidazole derivatives and screened in vitro by micro dilution technique for their amoebicidal activity with a view to search for a more effective agent against Entamoeba histolytica suggests that compound 2 and 3 might be endowed with important antiamoebic properties since they showed IC(50 )values in a microM range.
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, -110025, New Delhi, India.
authors.forename: Neelam
authors.initials: N
authors.lastname: Bharti
authors.lastname: Shailendra
authors.forename: M T
authors.initials: MT
authors.lastname: Gonzalez Garza
authors.forename: Delia E
authors.initials: DE
authors.lastname: Cruz-Vega
authors.forename: J
authors.initials: J
authors.lastname: Castro-Garza
authors.forename: Kishwar
authors.initials: K
authors.lastname: Saleem
authors.forename: Fehmida
authors.initials: F
authors.lastname: Naqvi
authors.forename: Mannar R
authors.initials: MR
authors.lastname: Maurya
authors.forename: Amir
authors.initials: A
authors.lastname: Azam
mesh_terms: D000563:Amebicides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D004748:Entamoeba histolytica / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008024:Ligands; D008982:Molybdenum / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014639:Vanadium / Q000737:chemistry
chemical_list: D000563:Amebicides; D001562:Benzimidazoles; D008024:Ligands; D009942:Organometallic Compounds; D014639:Vanadium; D008982:Molybdenum