title: Automated parallel solid-phase synthesis of non-peptide CCR1 receptor antagonists.
abstract: An automated, parallel, solid-phase synthesis and screening strategy using commercially available aryl acetic acids as starting materials has discovered novel, non-peptide CCR1 antagonists (K(i) < 100 nM).
authors.affiliation: Berlex Biosciences, 15049 San Pablo Ave, Richmond, CA 94804, USA.
authors.forename: Brad O
authors.initials: BO
authors.lastname: Buckman
authors.forename: Ameen
authors.initials: A
authors.lastname: Ghannam
authors.forename: Li
authors.initials: L
authors.lastname: Angela
authors.forename: Meina
authors.initials: M
authors.lastname: Liang
authors.forename: Raju
authors.initials: R
authors.lastname: Mohan
authors.forename: Howard P
authors.initials: HP
authors.lastname: Ng
mesh_terms: D000085:Acetates / Q000138:chemical synthesis / Q000737:chemistry; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy; D054389:Receptors, CCR1; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D000085:Acetates; D000893:Anti-Inflammatory Agents; D054389:Receptors, CCR1; D019707:Receptors, Chemokine