Can PK/PD be used in everyday clinical practice.
Over the last decade much insight has been gained in the relationships between dosing regimens of antimicrobials and bacterial eradication and clinical efficacy. These pharmacokinetic-pharmacodynamic (PK/PD) relationships have become available as tools in individualising antimicrobial therapy. To be able to do this, the PK parameters of the antimicrobial in the individual patient have to be known or estimated, and the MIC of the micro-organism causing the infection, known. In our hospital, we have started a programme using this approach. Preliminary results suggest that dose optimisation leads to increased efficacy and lower costs.
Scaglione
Francesco
F
Department of Pharmacology, Toxicology and Chemotherapy, Faculty of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy. francesco.scaglione@unimi.it
D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008826:Microbial Sensitivity Tests; D010601:Pharmacology, Clinical; D016896:Treatment Outcome
D000890:Anti-Infective Agents