title: Motor function improvement following intrathecal baclofen pump placement in a patient with locked-in syndrome.
abstract: We describe a patient with locked-in syndrome who had minimal volitional motor function and severe spasticity in all four extremities. The patient showed a significant improvement in volitional motor function following intrathecal baclofen pump therapy to control spasticity. This case study suggests that intrathecal baclofen pump therapy might improve motor function in select patients with locked-in syndrome.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital Network, Boston, Massachusetts 02114-1198, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Cairns
authors.forename: Joel
authors.initials: J
authors.lastname: Stein
mesh_terms: D000328:Adult; D001418:Baclofen / Q000627:therapeutic use*; D020526:Brain Stem Infarctions / Q000150:complications; D006801:Humans; D015918:Infusion Pumps, Implantable; D008297:Male; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D009128:Muscle Spasticity / Q000188:drug therapy*; D011183:Postoperative Complications; D011782:Quadriplegia / Q000209:etiology / Q000534:rehabilitation*
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen