title: [Statistical study of probabilities of rectal palpation, total PSA, and PSA density in prostate cancer].
abstract: OBJECTIVE
  To analyze the probabilities of total PSA, digital rectal examination (DRE) and PSA density in prostate cancer diagnosed by ultrasound-guided sextant prostate biopsy.
  
  
  METHODS
  The clinical records of 170 patients with elevated PSA levels and/or symptomatic BPH that had been referred to the outpatient services of the urology department were reviewed. Ultrasound-guided sextant prostate biopsy was performed in all patients. Serum PSA and PSA density were determined before biopsy. Age and DRE findings were also analyzed.
  
  
  CONCLUSIONS
  Statistical analysis showed a significant difference (p < 0.00001) for DRE, PSA and PSA density in relation to the prostate biopsy. Concerning the magnitude of the effect of DRE adjusted for age. PSA and PSA density determined by logistic regression analysis, a significance was found for DRE (odds ratio: 9.7) and PSA density > 0.5 (odds ratio: 11.3). DRE showed a sensitivity of 59%, a specificity of 89% and a positive predictive value of 88%.
authors.affiliation: Servicio de Urología, Hospital Río Carrión, Palencia, España.
authors.forename: Roberto
authors.initials: R
authors.lastname: Ortiz Cabria
authors.forename: Miguel
authors.initials: M
authors.lastname: Adriazola Semino
authors.forename: Enrique
authors.initials: E
authors.lastname: Tejeda Bañez
authors.forename: Antonio
authors.initials: A
authors.lastname: Alonso Villalba
authors.forename: Emilio
authors.initials: E
authors.lastname: García Cobo
authors.forename: Francisco
authors.initials: F
authors.lastname: Romero Rodríguez
authors.forename: José Maria
authors.initials: JM
authors.lastname: Monfá Bosch
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001706:Biopsy; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D016017:Odds Ratio; D010173:Palpation; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014463:Ultrasonography
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D017430:Prostate-Specific Antigen