title: Laser induced thermotherapy (LITT) of experimental liver metastasis-detection of residual tumors using Gd-DTPA enhanced MRI.
abstract: OBJECTIVE
  The aim of this study was to evaluate the accuracy of Gd-DTPA MRI in the detection of recurrent tumor after laserinduced thermotherapy (LITT) of experimental liver metastases.
  
  
  METHODS
  LITT was performed at different energy levels in VX-2 tumor-bearing rabbits (n = 80). MRI and histology were placed at 0, 24, 96 hours, and 14 days. Signal intensities were calculated of the transition between thermally damaged and undamaged tissue (transition zone = TZ) and of the surrounding tissue (reference zone = RZ).
  
  
  RESULTS
  Tumor recurrence was seen in 47 animals. At 24 hours sensitivity, specificity and accuracy was 92, 100, and 95% in TZ and 23, 100, and 50% in RZ. At 14 days sensitivity, specificity and accuracy was 100, 11, and 60% in TZ and 100, 89, and 95% in RZ.
  
  
  CONCLUSIONS
  Recurrence is best excluded in TZ at 24 hour and in RZ at 14 day with an accuracy up to 95%.
authors.affiliation: Department of General, Vascular and Thoracic Surgery, University Medical Center Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm, Berlin, Germany. isbert@ukbf.fu-berlin.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Isbert
authors.forename: Jörg-P
authors.initials: JP
authors.lastname: Ritz
authors.forename: Andreas
authors.initials: A
authors.lastname: Schilling
authors.forename: André
authors.initials: A
authors.lastname: Roggan
authors.forename: Antje
authors.initials: A
authors.lastname: Heiniche
authors.forename: Karl-J
authors.initials: KJ
authors.lastname: Wolf
authors.forename: Gerhard
authors.initials: G
authors.lastname: Müller
authors.forename: Heinz J
authors.initials: HJ
authors.lastname: Buhr
authors.forename: Christoph-T
authors.initials: CT
authors.lastname: Germer
mesh_terms: D000818:Animals; D003287:Contrast Media; D019786:Gadolinium DTPA; D006979:Hyperthermia, Induced; D053685:Laser Therapy; D008114:Liver Neoplasms, Experimental / Q000175:diagnosis* / Q000556:secondary* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D009364:Neoplasm Recurrence, Local; D018365:Neoplasm, Residual; D011817:Rabbits; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA