[Pharmacological analysis of the antihypoxic action of aminobutyric acid derivatives].
The correlation-regressive and pharmacological analysis of butane acid derivates--ufibrat, Re2(isoC3H7COO)4Cl2Ta[Re2(GABA)2Cl4(H2O)2]Cl2--was made. It is established that among these substances antihypoxic activity on the hypercapnic hypoxic hypoxia have only ufibrat. It decrease mice's temperature of body, increase duration of period to the appearance of sudoms and the life longitudindity at the condition of hypercapnia-hypoxia.
Khrapak
V V
VV
Institute of Pharmacology and Toxicology, AMS of Ukraine, Medical Institute of Ukrainian Association of Folk Medicine, Kiev.
Oliĭnyk
S A
SA
Shevchenko
V Ie
VIe
Shtemenko
N I
NI
Shtemenko
O V
OV
D000613:Aminobutyrates / Q000737:chemistry* / Q000627:therapeutic use*; D000818:Animals; D006935:Hypercapnia / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000860:Hypoxia / Q000188:drug therapy*; D051379:Mice; D009942:Organometallic Compounds / Q000737:chemistry / Q000627:therapeutic use; D011422:Propionates / Q000008:administration & dosage / Q000627:therapeutic use*; D012211:Rhenium
D000613:Aminobutyrates; D000960:Hypolipidemic Agents; D009942:Organometallic Compounds; D011422:Propionates; C111771:undecyl 2-(4-chlorophenoxy)propionate; D012211:Rhenium