title: Clinimetric evaluation of a new overall disability scale in immune mediated polyneuropathies.
abstract: OBJECTIVE
  To determine the validity, reliability, and responsiveness of a new overall disability sum score in immune mediated polyneuropathies.
  
  
  METHODS
  Three impairment measures (MRC sum score, sensory sum score, grip strength (Vigorimeter)) and three disability scales (an overall disability sum score (ODSS), Hughes' functional scale (f score), Rankin scale) were assessed in a cross sectional group of 113 clinically stable patients (83 with Guillain-Barré syndrome, 22 with chronic inflammatory demyelinating polyneuropathy (CIDP), eight with a gammopathy related polyneuropathy). The ODSS was also used serially in 20 patients with recently diagnosed Guillain-Barré syndrome (n = 7) or CIDP (n = 13) and changing clinical conditions. Multiple regression studies were performed to compare the impact of impairment disturbances (independent variables) on the various disability scales (dependent variable).
  
  
  RESULTS
  Moderate to good construct validity (stable group: Spearman's rank test (absolute values), r = 0.41-0.79; longitudinal group: multiple correlation coefficient, R = 0.69-0.89; p < 0.006 for all associations) and reliability (intraclass correlation coefficient, R = 0.90-0.95; p < 0.0001) were demonstrated for the ODSS. Its SRM values were high (> 0.8), indicating good responsiveness. Impairment measures accounted for a higher variance proportion of the ODSS compared with the f score and Rankin (R = 0.64 v 0.56 and 0.45, respectively).
  
  
  CONCLUSIONS
  All clinimetric requirements were met by the overall (arm and leg) disability sum score in immune mediated polyneuropathies. Its use is therefore suggested in evaluating immune mediated polyneuropathies.
authors.affiliation: Department of Neurology, University Hospital Rotterdam/Erasmus University, dr Molewaterplein, Rotterdam, Netherlands. isjmerkies@hotmail.com
authors.forename: I S J
authors.initials: IS
authors.lastname: Merkies
authors.forename: P I M
authors.initials: PI
authors.lastname: Schmitz
authors.forename: F G A
authors.initials: FG
authors.lastname: van der Meché
authors.forename: J P A
authors.initials: JP
authors.lastname: Samijn
authors.forename: P A
authors.initials: PA
authors.lastname: van Doorn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D006233:Persons with Disabilities / Q000145:classification*; D005260:Female; D018737:Hand Strength; D006801:Humans; D008297:Male; D008875:Middle Aged; D019957:Motor Skills Disorders / Q000145:classification*; D009460:Neurologic Examination; D011115:Polyneuropathies / Q000145:classification / Q000150:complications*; D012680:Sensitivity and Specificity