Distribution of azithromycin in plasma and tonsil tissue after repeated oral administration of 10 or 20 milligrams per kilogram in pediatric patients.
Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribution of azithromycin, suggesting the achievement of enhanced therapeutic concentrations at infective sites of the upper respiratory tract.
Blandizzi
Corrado
C
Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University Hospital of Pisa, Pisa, Italy.
Malizia
Tecla
T
Batoni
Giovanna
G
Ghelardi
Emilia
E
Baschiera
Fabio
F
Bruschini
Paolo
P
Senesi
Sonia
S
Campa
Mario
M
Del Tacca
Mario
M
D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017963:Azithromycin / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D014066:Palatine Tonsil / Q000378:metabolism*; D014069:Tonsillitis / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D017963:Azithromycin