On the time resolution of event-related desynchronization: a simulation study.
OBJECTIVE
To investigate the time resolution of different methods for the computation of event-related desynchronization/synchronization (ERD/ERS), including one based on Hilbert transform.


METHODS
In order to better understand the time resolution of ERD/ERS, which is a function of factors such as the exact computation method, the frequency under study, the number of trials, and the sampling frequency, we simulated sudden changes in oscillation amplitude as well as very short and closely spaced events.


RESULTS
Hilbert-based ERD yields very similar results to ERD integrated over predefined time intervals (block ERD), if the block length is half the period length of the studied frequency. ERD predicts the onset of a change in oscillation amplitude with an error margin of only 10-30 ms. On the other hand, the time the ERD response needs to climb to its full height after a sudden change in oscillation amplitude is quite long, i.e. between 200 and 500 ms. With respect to sensitivity to short oscillatory events, the ratio between sampling frequency and electroencephalographic frequency band plays a major role.


CONCLUSIONS
(1) The optimal time interval for the computation of block ERD is half a period of the frequency under investigation. (2) Due to the slow impulse response, amplitude effects in the ERD may in reality be caused by duration differences. (3) Although ERD based on the Hilbert transform does not yield any significant advantages over classical ERD in terms of time resolution, it has some important practical advantages.
Knösche
Thomas R
TR
MEG Group, Max Planck Institute of Cognitive Neuroscience, PO Box 500355, 04303, Leipzig, Germany. knoesche@cns.mpg.de
Bastiaansen
Marcel C M
MC
D003198:Computer Simulation; D003344:Cortical Synchronization; D005071:Evoked Potentials / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D010507:Periodicity; D011930:Reaction Time / Q000502:physiology