[The change of alveolar fluid clearance in acute lung injury rat].
OBJECTIVE
To establish the animal model of lung injury caused by hydrochloric acid in rats, measure the alveolar fluid clearance (AFC) in different acidic condition.


METHODS
32 rats were randomly divided into 4 groups which were control group (pH = 7.4) and HCl groups (pH = 7.0, 4.5, 2.5). The animals were anesthetized and ventilated for 1 hour. Blood gas analysis was performed, then the permeability of lung epithelial barrier and AFC were measured.


RESULTS
The permeability of lung epithelial barrier, PaO(2) and AFC of pH 7.0 group were similar to control group (P > 0.05), but declined in pH 4.5 and 2.5 groups (P < 0.05).


CONCLUSIONS
The alveolar epithelium and the alveolar epithelial barrier are resistant to the injurious effects of acid, but high concentration acid can induce damage.
Chen
Zhiwei
Z
Department of Pulmonary, Shanghai Chest Hospital, Shanghai 200030, China.
Bai
Chunxue
C
Fang
Xiaohui
X
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D004195:Disease Models, Animal; D006863:Hydrogen-Ion Concentration; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000378:metabolism*