title: [Pharmacodynamics and pharmacokinetics of prostaglandins and their derivates in eye tissues].
abstract: This paper presents the classification of prostaglandins and their receptors. The ocular distribution of the receptors and the effects of their agonists are presented. The efficacy in lowering intraocular pressure of different prostaglandins and their derivatives, especially the PGF2a group, is discussed. The history of latanoprost development is also presented. Good therapeutic index characterises two antiglaucomatous PG-derivatives: latanoprost and unoprostone.
authors.affiliation: Katedry i Zakładu Farmakologii AM we Wrocławiu.
authors.forename: M R
authors.initials: MR
authors.lastname: Szaliński
authors.forename: A
authors.initials: A
authors.lastname: Turno-Krecicka
mesh_terms: D000818:Animals; D018916:Blood-Aqueous Barrier / Q000187:drug effects; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D005901:Glaucoma / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D011453:Prostaglandins / Q000493:pharmacokinetics / Q000494:pharmacology*; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology
chemical_list: D011453:Prostaglandins; D011461:Prostaglandins F, Synthetic; C072630:isopropyl unoprostone; D000077338:Latanoprost; D015237:Dinoprost