title: Recombinant protein expression for therapeutic applications.
abstract: In recent years, the number of recombinant proteins used for therapeutic applications has increased dramatically. Many of these applications involve complex glycoproteins and antibodies with relatively high production needs. These demands have driven the development of a variety of improvements in protein expression technology, particularly involving mammalian and microbial culture systems.
authors.affiliation: Cell Culture & Fermentation Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. andersen@gene.com
authors.forename: Dana C
authors.initials: DC
authors.lastname: Andersen
authors.forename: Lynne
authors.initials: L
authors.lastname: Krummen
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D001709:Biotechnology / Q000379:methods* / Q000639:trends*; D016466:CHO Cells; D002417:Cattle; D006224:Cricetinae; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D051379:Mice; D011994:Recombinant Proteins / Q000235:genetics* / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins