Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor.
Hematopoietic progenitor cells can be mobilized from the bone marrow to the blood by a wide variety of stimuli, including hematopoietic growth factors, chemotherapy, and chemokines. Increasingly, mobilized peripheral blood hematopoietic progenitor cells instead of bone marrow hematopoietic progenitor cells have been used to reconstitute hematopoiesis after myeloablative therapy because of their reduced engraftment times and relative ease of collection. A striking feature of hematopoietic progenitor cell mobilization is the ability of hematopoietic growth factors with distinct cellular targets and biologic activities to mobilize a similar spectrum of pluripotent and lineage-committed hematopoietic progenitor cells into the blood. Recent studies have identified some of the key adhesive interactions that regulate hematopoietic progenitor cell trafficking in the bone marrow. In addition, pathways linking mobilizing agents to hematopoietic progenitor cell mobilization have begun to be elucidated. This review summarizes these advances, emphasizing the mechanisms regulating granulocyte colony-stimulating factor-induced mobilization.
Thomas
John
J
Washington University School of Medicine, Division of Oncology, Section of Stem Cell Biology, St. Louis, Missouri 63110-1093, USA.
Liu
Fulu
F
Link
Daniel C
DC
D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000378:metabolism; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D051379:Mice; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
D015815:Cell Adhesion Molecules; D016188:Receptors, Granulocyte Colony-Stimulating Factor; D016179:Granulocyte Colony-Stimulating Factor