title: A convenient synthesis of cis and trans 4-tert-butoxycarbonyl-substituted cyclohexylglycine.
abstract: A novel synthesis of cis and trans substituted 4-tert-butoxycarbonyl cyclohexylglycines via asymmetric aminohydroxylation of vinyl styrene followed by reduction of the aromatic ring and subsequent oxidation is reported.
authors.affiliation: Schering Plough Research Institute, A301, K-15, mailstop 3545, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. Srikanth.Venkatraman@spcorp.com
authors.forename: Srikanth
authors.initials: S
authors.lastname: Venkatraman
authors.forename: F George
authors.initials: FG
authors.lastname: Njoroge
authors.forename: Viyyoor
authors.initials: V
authors.lastname: Girijavallabhan
authors.forename: Andrew T
authors.initials: AT
authors.lastname: McPhail
mesh_terms: D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D018360:Crystallography, X-Ray; D003500:Cyclization; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013343:Styrenes / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D013343:Styrenes; D014753:Vinyl Compounds; D005998:Glycine