Chromosome segregation: playing polo in prophase.
During mitosis, in most eukaryotes, cohesin is removed from chromosomes in two steps. A paper in the March issue of Molecular Cell identifies Polo-like kinase as a key regulator for the first step that releases much of cohesin during prophase.
Weitzer
Stefan
S
Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, WC2A 3PX, London, United Kingdom.
Uhlmann
Frank
F
D000818:Animals; D018797:Cell Cycle Proteins; D020090:Chromosome Segregation / Q000502:physiology*; D029721:Drosophila Proteins; D011418:Prophase / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D029867:Xenopus Proteins; D000097869:Polo-Like Kinase 1
D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D017346:Protein Serine-Threonine Kinases; D029867:Xenopus Proteins; C101085:Plk1 protein, Xenopus; D000097869:Polo-Like Kinase 1