title: HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection.
abstract: We have previously shown that Vpu is rarely targeted by HIV-1-specific cytotoxic T lymphocytes (CTL). The present report extends these findings and describes the characterization of the first CTL epitope within HIV-1 Vpu, identified in an individual with long-term non-progressive HIV-1 infection. The epitope was shown to be highly conserved among HIV clade B sequences and is restricted by HLA-A*3303, an HLA allele commonly seen in Asian and west-African populations.
authors.affiliation: Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
authors.forename: Marylyn M
authors.initials: MM
authors.lastname: Addo
authors.forename: Marcus
authors.initials: M
authors.lastname: Altfeld
authors.forename: Almas
authors.initials: A
authors.lastname: Rathod
authors.forename: Michelle
authors.initials: M
authors.lastname: Yu
authors.forename: Xu G
authors.initials: XG
authors.lastname: Yu
authors.forename: Philip J R
authors.initials: PJ
authors.lastname: Goulder
authors.forename: Eric S
authors.initials: ES
authors.lastname: Rosenberg
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Walker
mesh_terms: D000595:Amino Acid Sequence; D016384:Consensus Sequence; D003602:Cytotoxicity, Immunologic; D018450:Disease Progression; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000276:immunology*; D015234:HLA-A Antigens / Q000276:immunology*; D054298:Human Immunodeficiency Virus Proteins; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D054334:Viral Regulatory and Accessory Proteins / Q000276:immunology*; D000086082:Viroporin Proteins
chemical_list: D015234:HLA-A Antigens; D054298:Human Immunodeficiency Virus Proteins; D010446:Peptide Fragments; D054334:Viral Regulatory and Accessory Proteins; C082945:HLA-A*33 antigen; C514859:vpu protein, Human immunodeficiency virus 1; D000086082:Viroporin Proteins