[Study on chitosan and PHBHHx used as nerve regeneration conduit material].
Both Chitosan and PHBHHx are natural, biodegradable biomedical materials. In this article, their ability to be made as nerve regeneration conduits are evaluated by studying their wettability, changes of the second structure of protein absorbed on their surface, growing status of fetal rat cerebral cortex nerve cells cultured on them, mechanical properties and ability to be processed later. The results indicate that both Chitosan and PHBHHx are promising nerve conduit materials.
Yang
Yinye
Y
Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084.
Li
Xunhu
X
Li
Guofu
G
Zhao
Nanming
N
Zhang
Xiufang
X
D000818:Animals; D001672:Biocompatible Materials; D002264:Carboxylic Acids; D002448:Cell Adhesion; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D002686:Chitin / Q000031:analogs & derivatives*; D048271:Chitosan; D005260:Female; D006885:Hydroxybutyrates; D009416:Nerve Regeneration / Q000502:physiology*; D011108:Polymers; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013499:Surface Properties
D001672:Biocompatible Materials; D002264:Carboxylic Acids; D006885:Hydroxybutyrates; D011108:Polymers; D002686:Chitin; D048271:Chitosan