Hodgkin's disease presenting as cholestatic hepatitis with prominent ductal injury.
In advanced stages of Hodgkin's disease, liver involvement is common. However, Hodgkin's disease mimicking cholestatic hepatitis at presentation is rare. We describe a patient with Hodgkin's disease who was initially considered to have acute cholestatic hepatitis. Liver biopsy demonstrated prominent bile duct injury associated with a florid inflammatory reaction. These changes may represent an early stage of ductal injury, subsequently leading to vanishing bile duct syndrome, a recently documented mechanism of cholestasis in Hodgkin's disease.
Liangpunsakul
Suthat
S
Department of Medicine, Division of Gastroenterology and Hepatology, Indiana School of Medicine, Indianapolis, Indiana, USA. sliangpu@iupui.edu
Kwo
Paul
P
Koukoulis
George K
GK
D000368:Aged; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D002779:Cholestasis / Q000209:etiology* / Q000473:pathology; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008297:Male