[Effects of nitric oxide donor SIN-1 on calcium transport in rat cardiac sarcoplasmic reticulum].
The effects of non-enzymatic disintegration of SIN-1 products (nitric oxide, superoxide anion and peroxynitrite) on Ca(2+)-transport of sarcoplasmic reticulum were studied on homogenates of rats myocardium. It was shown that SIN-1 (30 microM) exerts a significant activating effect on ryanodine-sensitive calcium channels resulted in three-fold increase of Ca2+ release rate via these channels. Such effect of SIN-1 realized mainly by nitric oxide effect and, partially, superoxide radical. SIN-1 did not effect the Ca(2+)-ATPase activity of sarcoplasmic reticulum.
Harmatina
O Iu
OIu
A. A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Azarov
V I
VI
Moĭbenko
O O
OO
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D017136:Ion Transport / Q000187:drug effects; D008981:Molsidomine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D009569:Nitric Oxide / Q000494:pharmacology; D020030:Nitric Oxide Donors / Q000378:metabolism / Q000494:pharmacology*; D030421:Peroxynitrous Acid / Q000494:pharmacology; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism; D013481:Superoxides / Q000494:pharmacology
D015220:Calcium Channels; D020030:Nitric Oxide Donors; D013481:Superoxides; D030421:Peroxynitrous Acid; D009569:Nitric Oxide; C002385:linsidomine; D008981:Molsidomine; D002118:Calcium