Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis.
Sclerosing pancreatitis is associated with raised concentrations of IgG4. We treated 22 patients with sclerosing pancreatitis, and identified and followed-up three with concomitant hydronephrosis caused by ureteral mass, later diagnosed as retroperitoneal fibrosis. We histologically examined the ureteral and pancreatic lesions of these patients and noted abundant infiltration of IgG4-bearing plasma cells in both tissues. Treatment with corticosteroids lowered serum concentrations of IgG4. IgG4 might also have a pathological role in a systemic fibrosing process that includes pancreatic and retroperitoneal lesions.
Hamano
Hideaki
H
Second Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan.
Kawa
Shigeyuki
S
Ochi
Yasuhide
Y
Unno
Hiroshi
H
Shiba
Nobuhiko
N
Wajiki
Masahisa
M
Nakazawa
Koh
K
Shimojo
Hisashi
H
Kiyosawa
Kendo
K
D000368:Aged; D002908:Chronic Disease; D006801:Humans; D006869:Hydronephrosis / Q000209:etiology*; D007074:Immunoglobulin G / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology*; D010195:Pancreatitis / Q000150:complications* / Q000473:pathology; D010950:Plasma Cells / Q000276:immunology; D012185:Retroperitoneal Fibrosis / Q000150:complications* / Q000175:diagnosis*; D012598:Sclerosis / Q000150:complications; D014513:Ureter / Q000473:pathology*
D007074:Immunoglobulin G