Minimal model for complex dynamics in cellular processes.
Cellular functions are controlled and coordinated by the complex circuitry of biochemical pathways regulated by genetic and metabolic feedback processes. This paper aims to show, with the help of a minimal model of a regulated biochemical pathway, that the common nonlinearities and control structures present in biomolecular interactions are capable of eliciting a variety of functional dynamics, such as homeostasis, periodic, complex, and chaotic oscillations, including transients, that are observed in various cellular processes.
Suguna
C
C
Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
Chowdhury
K K
KK
Sinha
S
S
D001669:Biochemical Phenomena; D001671:Biochemistry; D055592:Biophysical Phenomena; D001703:Biophysics; D005246:Feedback; D008954:Models, Biological; D017711:Nonlinear Dynamics; D013816:Thermodynamics