title: Comparative study of pressure-flow parameters.
abstract: Methods for quantification of bladder outlet obstruction (BOO) are still controversial. Parameters such as detrusor opening pressure (p(det.open)), maximum detrusor pressure (p(det.max)), minimum voiding pressure (p(det.min.void)), and detrusor pressure at maximum flow rate (P(det.Qmax)) separate obstructed from nonobstructed patients to some extent, but two nomograms, the Abrams-Griffiths nomogram and the linearized passive urethral resistance relation (LinPURR), are more accepted for this purpose, along with the urethral resistance algorithm. In this retrospective, methodologic study, we evaluated the properties of these parameters with regard to test-retest reproducibility and ability to detect a moderate (pharmacologic) and a pronounced (surgical) relief of bladder outlet obstruction. We studied the pressure-flow charts of 42 patients who underwent 24 weeks of androgen suppressive therapy, 42 corresponding patients who received placebo, and 30 patients who had prostate surgery. The patients performed repeat void pressure-flow examinations before and after treatment or placebo. The various parameters were compared. Among the bladder pressure parameters, P(det.Qmax) seemed to have some advantages, supporting the belief that it is the most relevant detrusor pressure parameter to include in nomograms to quantify BOO. In assessment of a large decrease in urethral resistance, such as after TURp, resistance parameters that are based on maximum flow rate as well as detrusor pressure are preferable.
authors.affiliation: Department of Urology, Ullevaal University Hospital, Oslo, Norway.
authors.forename: Lars M
authors.initials: LM
authors.lastname: Eri
authors.forename: Nicolai
authors.initials: N
authors.lastname: Wessel
authors.forename: Ole
authors.initials: O
authors.lastname: Tysland
authors.forename: Viktor
authors.initials: V
authors.lastname: Berge
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000008:administration & dosage; D000813:Anilides / Q000008:administration & dosage; D018849:Controlled Clinical Trials as Topic; D003950:Diagnostic Techniques, Urological; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009122:Muscle Hypertonia / Q000503:physiopathology; D009570:Nitriles; D011312:Pressure; D011470:Prostatic Hyperplasia / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014105:Tosyl Compounds; D016896:Treatment Outcome; D001748:Urinary Bladder Neck Obstruction / Q000503:physiopathology; D014563:Urodynamics
chemical_list: D000726:Androgen Antagonists; D000813:Anilides; D009570:Nitriles; D014105:Tosyl Compounds; C053541:bicalutamide; D016729:Leuprolide