Outbreak of infections caused by Enterobacter cloacae producing the integron-associated beta-lactamase IBC-1 in a neonatal intensive care unit of a Greek hospital.
Nineteen of 27 ceftazidime-resistant Enterobacter cloacae isolates from a neonatal intensive care unit in Thessaloniki, Greece, had genes coding for the novel extended-spectrum beta-lactamase IBC-1; 18 of those 19 harbored similar conjugative plasmids and belonged to two distinct genetic lineages. A synergy test with ceftazidime and imipenem enabled us to identify five unrelated bla(IBC-1)-carrying E. cloacae isolates from other wards of the hospital. It seems that this integron-associated gene is capable of dispersing both by clonal spread and by gene dissemination.
Kartali
Georgia
G
Department of Microbiology, Hippokration General Hospital, Thessaloniki, Greece.
Tzelepi
Eva
E
Pournaras
Spyros
S
Kontopoulou
Constantina
C
Kontos
Fanourios
F
Sofianou
Danai
D
Maniatis
Antonios N
AN
Tsakris
Athanassios
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D018550:Cephalosporin Resistance; D004196:Disease Outbreaks; D016972:Enterobacter cloacae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology; D006115:Greece / Q000453:epidemiology; D006785:Hospitals, University; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019426:Integrases / Q000235:genetics; D015931:Intensive Care, Neonatal; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D002442:Ceftazidime; D019426:Integrases; C115006:integron integrase IntI1; C413407:integron-associated beta-lactamase 1; D001618:beta-Lactamases