title: [Cancer prevention in familial cancer].
abstract: We established a protocol for and will conduct an interventional randomized controlled trial for the prevention of colorectal cancer. The subjects will be 100 patients with hereditary non-polyposis colorectal cancer. Two regimens were formulated for the prevention of colorectal cancer. Regimen A is dietary guidance and ingestion of aged garlic extract (AGE) capsules, and regimen B is dietary guidance and non-function capsules. The main end point of the trial is number and size of colorectal adenomas after 2 years. Subject recruiting was started in March, 2002. The trial will be completed in September, 2005.
authors.affiliation: Department of Cancer Epidemiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3 Nakamichi, 1-Chome, Higashinari-ku, Osaka 537-8511, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishikawa
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000517:prevention & control*; D004032:Diet; D015444:Exercise; D005247:Feeding Behavior; D005737:Garlic / Q000737:chemistry*; D006801:Humans; D008019:Life Style; D010936:Plant Extracts / Q000627:therapeutic use; D016540:Smoking Cessation
chemical_list: D010936:Plant Extracts