title: Novel diamide-based inhibitors of IMPDH.
abstract: A series of novel amide-based small molecule inhibitors of inosine monophosphate dehydrogenase is described. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are presented.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. henry.gu@bms.com
authors.forename: Henry H
authors.initials: HH
authors.lastname: Gu
authors.forename: Edwin J
authors.initials: EJ
authors.lastname: Iwanowicz
authors.forename: Junqing
authors.initials: J
authors.lastname: Guo
authors.forename: Scott H
authors.initials: SH
authors.lastname: Watterson
authors.forename: Zhongqi
authors.initials: Z
authors.lastname: Shen
authors.forename: William J
authors.initials: WJ
authors.lastname: Pitts
authors.forename: T G Murali
authors.initials: TG
authors.lastname: Dhar
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Fleener
authors.forename: Katherine
authors.initials: K
authors.lastname: Rouleau
authors.forename: N Z
authors.initials: NZ
authors.lastname: Sherbina
authors.forename: Mark
authors.initials: M
authors.lastname: Witmer
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Tredup
authors.forename: Diane
authors.initials: D
authors.lastname: Hollenbaugh
mesh_terms: D002384:Catalysis; D003958:Diamide / Q000737:chemistry* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D003958:Diamide; D007168:IMP Dehydrogenase