[An analysis of adhered cells on the surface of F-heparin surface modified intraocular lenses implanted into rhesus monkeys' eyes].
OBJECTIVE
To study the biocompatibility of F-heparin surface modified intraocular lenses (IOLs) by observing cellular reaction on the surface of IOLs implanted into the rhesus monkeys' eyes.


METHODS
Ten monkeys (20 eyes) were classified into two groups. PMMA IOLs and F-heparin modified IOLs were respectively implanted into 10 monkeys' eyes. The IOLs were examined with computer image analysis, light microscope (LM) and scanning electron microscope (SEM) at postoperative 180 and 360 days.


RESULTS
A few of adhered cells were on the surface of the central part of the IOL and more on the border of the IOL optics. The giant cells deposited on the surface occupied the largest area and the number of the macrophages was the greatest. The cells deposited on the surface of the IOLs in the F-heparin modified group were less than that in the non-modified group. In the modified group, there was fine granular proteinaceous membrane on the surface of the IOLs, but in the non-modified group there was fibrinous reticular proteinaceous membrane.


CONCLUSIONS
The biocompatibility of the F-heparin surface modified IOLs is better than that of non-modified PMMA IOLs.
Wang
Guiqin
G
International Intraocular Implant Training Center, Tianjin Medical University, Tianjin 300070, China (Email: webmaster@tru.org.cn)
Yuan
Jiaqin
J
Sun
Huimin
H
Gu
Hanqing
H
Xu
Yanshan
Y
Dong
Yali
Y
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects* / Q000502:physiology; D020099:Coated Materials, Biocompatible / Q000494:pharmacology; D005461:Fluorine / Q000494:pharmacology*; D015726:Giant Cells / Q000502:physiology; D006493:Heparin / Q000494:pharmacology*; D019654:Lens Implantation, Intraocular / Q000379:methods; D007910:Lenses, Intraocular; D008253:Macaca mulatta; D008264:Macrophages / Q000502:physiology; D013499:Surface Properties
D020099:Coated Materials, Biocompatible; D005461:Fluorine; D006493:Heparin