title: Trimethylsilylethynyl ketones as surrogates for ethynyl ketones in the double Michael reaction.
abstract: Trimethylsilylethynyl ketones can be desilylated in the presence of a tethered carbon diacid and induced to undergo a double Michael reaction in situ. The trimethylsilylethynyl ketones can serve as surrogates of ethynyl ketones that are difficult to prepare or isolate.
authors.affiliation: Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506-0055, USA.
authors.forename: Derrick S
authors.initials: DS
authors.lastname: Holeman
authors.forename: Ravindra M
authors.initials: RM
authors.lastname: Rasne
authors.forename: Robert B
authors.initials: RB
authors.lastname: Grossman
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012821:Silanes / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000473:Alkanes; D007659:Ketones; D012821:Silanes