Molecular mechanisms of CNS synaptogenesis.
Synapses of the mammalian CNS are asymmetric sites of cell-cell adhesion between nerve cells. They are designed to mediate the rapid and efficient transmission of signals from the presynaptic bouton of one neuron to the postsynaptic plasma membrane of a second neuron. Significant progress has been made in the characterization of the structural, functional and developmental assembly of CNS synapses. Recent progress has been made in understanding the molecular and cellular mechanisms that underlie synaptogenesis, in particular that of glutamatergic synapses of the CNS.
Garner
Craig C
CC
Department of Psychiatry and Behavioral Science, Stanford University, Palo Alto, CA 94304-5485, USA. garner@stanford.edu
Zhai
R Grace
RG
Gundelfinger
Eckart D
ED
Ziv
Noam E
NE
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002490:Central Nervous System / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D006801:Humans; D009435:Synaptic Transmission / Q000502:physiology*