title: [Bactericidal activity of biapenem against various efflux system mutants of Pseudomonas aeruginosa].
abstract: The bactericidal activity of biapenem, a new carbapenem, against various efflux-mutants of Pseudomonas aeruginosa was compared with those of imipenem, panipenem, meropenem and ceftazidime. The bactericidal activity of biapenem against P. aeruginosa KG5001, a strain deficient in MexAB-OprM, MexCD-OprJ and MexXY-OprM, was very strong compared with those of imipenem and meropenem. In terms of bactericidal activities, biapenem and imipenem had similar activities against P. aeruginosa KG5003, a strain overexpressing MexAB-OprM, as against P. aeruginosa KG5001, however meropenem and ceftazidime had weaker activities against KG5003 than KG5001. The bactericidal activity against P. aeruginosa KG5007, a strain overexpressing MexCD-OprJ, was observed only by biapenem. The bactericidal activity of biapenem was strong and not influenced by all of these three efflux systems.
authors.affiliation: Pharmaceutical Research Center, Meiji Seika Kaisha, LTD. 760 Morooka-cho, Kohoku-ku, Yokohama, Kanagawa, 222-8567, Japan.
authors.forename: Tooru
authors.initials: T
authors.lastname: Hiraishi
authors.forename: Aiko
authors.initials: A
authors.lastname: Miyata
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Takata
authors.forename: Minako
authors.initials: M
authors.lastname: Araake
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Naomasa
authors.initials: N
authors.lastname: Gotoh
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nishino
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D015378:Imipenem / Q000494:pharmacology; D000077731:Meropenem; D009154:Mutation; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics*; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D013845:Thienamycins; D015378:Imipenem; D002442:Ceftazidime; D000077731:Meropenem; C039536:panipenem; C065257:biapenem