Nickel(0)/dihydroimidazol-2-ylidene complex catalyzed coupling of aryl chlorides and amines.
A general and simple nickel-catalyzed coupling of aryl chlorides and amines is reported. The scope and limitations of the coupling process using Ni(0), 1,3-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene, and NaO-t-Bu as base were investigated. Secondary cyclic and acyclic amines and anilines provided the arylamine coupling products in good to excellent yields. Compared to palladium-catalyzed aminations, this procedure offers an alternative route to N-substituted anilines starting from readily available aryl chlorides.
Desmarets
Christophe
C
Synthèse Organique et Réactivité, UMR 7565, Université Henri Poincaré, Nancy I, Faculté des Sciences, BP 239, 54506 Vandoeuvre les Nancy Cedex, France.
Schneider
Raphaël
R
Fort
Yves
Y