Designer skin: lineage commitment in postnatal epidermis.
The epidermis is populated by stem cells that produce daughters that differentiate to form the interfollicular epidermis, hair follicles and sebaceous glands. Diffusible factors, cell-cell contact and extracellular matrix proteins are all important components of the microenvironment of individual stem cells and profoundly affect the differentiation pathways selected by their progeny. Here, we summarize what is known about stem-cell populations and lineage relationships within the epidermis. We also present evidence that postnatal epidermis can be reprogrammed, altering the number and location of cells that differentiate along specific epidermal lineages.
Niemann
Catherin
C
Keratinocyte Laboratory, Cancer Research UK, 44 Lincoln's Inn Fields, WC2A 3PX., London, UK.
Watt
Fiona M
FM
D000818:Animals; D002455:Cell Division; D019070:Cell Lineage; D000078404:Epidermal Cells; D004817:Epidermis / Q000254:growth & development; D018859:Hair Follicle / Q000166:cytology; D006801:Humans; D012627:Sebaceous Glands / Q000166:cytology; D012867:Skin / Q000166:cytology*; D013234:Stem Cells / Q000166:cytology*