Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis.
While increased concentrations of C-reactive protein (CRP) are associated with increased vascular risk, little information is available describing genetic determinants of this effect. In a large prospective cohort of apparently healthy men, we found plasma CRP concentrations to be significantly reduced among carriers of a 1059G/C polymorphism in the human CRP gene (GC or CC) as compared with non-carriers (GG). However, the polymorphism examined was not significantly associated with risk of arterial thrombosis despite the fact that CRP concentrations are a potent independent predictor of future vascular events in this cohort. These data suggest that genetic and environmental determinants each importantly contribute to the vascular risk associated with inflammation.
Zee
Robert Y L
RY
Division of Preventive Medicine, The Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215-1204, USA. rzee@rics.bwh.harvard.edu
Ridker
Paul M
PM
D000368:Aged; D000483:Alleles; D001158:Arteries / Q000473:pathology*; D002097:C-Reactive Protein / Q000235:genetics* / Q000378:metabolism*; D016022:Case-Control Studies; D015331:Cohort Studies; D003328:Coronary Thrombosis / Q000097:blood* / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D011237:Predictive Value of Tests; D012307:Risk Factors; D013997:Time Factors
D002097:C-Reactive Protein