Hypotensive effect of the methanolic extract of Mimusops elengi in normotensive rats.
The methanolic extract of Mimusops elengi caused hypotensive activity in anaesthetized rats. On intravenous administration (i.v.) at a dose range of 2-16 mg/kg, it produced about a 7-38% fall in mean arterial blood pressure, in a dose-dependent manner. The effect was independent of adrenergic, muscarinic and histaminergic receptors. The hypotension was also unchanged after autonomic ganglion or angiotensin-converting-enzyme blockade. Administration of calcium channel blockers, however, including nifedipine (0.9 mg/kg) and verapamil (3.9 mg/kg), caused corresponding reductions of 81 and 64% in extract-induced hypotension. These data imply M. elengi might possess calcium-blocking activity which would explain its hypotensive effect.
Dar
A
A
H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan. dar@khi.comsats.net.pk
Behbahanian
S
S
Malik
A
A
Jahan
N
N
D000208:Acute Disease; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007022:Hypotension / Q000139:chemically induced; D007928:Lethal Dose 50; D008297:Male; D000432:Methanol; D051379:Mice; D009543:Nifedipine / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D029632:Sapotaceae / Q000737:chemistry*; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology
D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D010936:Plant Extracts; D014700:Verapamil; D009543:Nifedipine; D000432:Methanol