title: Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma.
abstract: A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-beta therapy against malignant melanoma. Renal pathologic findings were consistent with minimal change nephrotic syndrome (MCNS) showing extensive foot process effacement of visceral glomerular epithelial cells (podocyte). Nephrotic range proteinuria gradually regressed after stoppage of local injection of IFN-beta without glucocorticoid treatment. To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-beta therapy for the malignant melanoma.
authors.affiliation: Department of Medicine III, Okayama University Medical School, Japan. onaka24@hotmail.com
authors.forename: Kazushi
authors.initials: K
authors.lastname: Nakao
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Eiichi
authors.initials: E
authors.lastname: Makino
authors.forename: Hironori
authors.initials: H
authors.lastname: Matsuura
authors.forename: Akiko
authors.initials: A
authors.lastname: Ohmoto
authors.forename: Taro
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Haruo
authors.initials: H
authors.lastname: Ichikawa
authors.forename: Jun
authors.initials: J
authors.lastname: Wada
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Makino
mesh_terms: D003131:Combined Modality Therapy; D003920:Diabetes Mellitus; D006801:Humans; D016899:Interferon-beta / Q000009:adverse effects* / Q000627:therapeutic use; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000209:etiology* / Q000473:pathology; D011507:Proteinuria / Q000209:etiology
chemical_list: D016899:Interferon-beta