[Level of plasma lysophosphatidic acid in patients with cerebral ischemic attack, a preliminary study].
OBJECTIVE
To study the level of plasma lysophosphatidic acid (LPA) in patients with TIA, cerebral thrombosis or possible ischemic attack.


METHODS
Phospholipid was extracted from plasma of patients with TIA, cerebral thrombosis or possible ischemic attack by organic solvent. Lysophosphatidic acid was isolated further. The quantity of LPA was determined by assaying its phosphorous component.


RESULTS
LPA level of patients with TIA, cerebral thrombosis or possible ischemic attack were 2.14 +/- 1.02, 1.50 +/- 0.85, and 1.73 +/- 1.14 micromol/L blood plasma respectively, all significantly higher than that in control group (1.00 +/- 0.70 micromol/L, P < 0.05). The plasma LPA level decreased after anticoagulant treatment.


CONCLUSIONS
As a molecular marker released by activated platelets in vivo, plasma PLA may be valuable in diagnosis of cerebral ischemic attack.
Sun
Yuheng
Y
Department of Neurology, Beijing Ji Shui Tan Hospital, Beijing Capital Medical Unimversity, Beijing 100035, China.
Wu
Qizhuan
Q
Yao
Cunshan
C
Huang
Shichang
S
Tang
Zhaoshu
Z
Li
Zhenguang
Z
Bao
Heqiu
H
Li
Song
S
Zhou
Weijin
W
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood*; D008246:Lysophospholipids / Q000097:blood*; D008297:Male; D008875:Middle Aged
D008246:Lysophospholipids