[Molecular mechanism of HIV-1 replication].
Host factors that associate retrovirus replication also play an important role in regulating cellular physiological conditions. Therefore, a discovery of HIV related cellular proteins might open up understanding mechanisms for essential cellular machinery. Recent advances in biotechnology have shed new light on the molecular mechanism of HIV replication. We choose three topics about HIV replication and discuss them; a role of ubiquitin and vacuolar protein sorting pathway during virus budding, new players, integrase and central DNA flap, that regulate the translocation of preintegration complex into nucleus, and a relationship between basic model for core formation and fullerene molecule.
Kawano
Yuji
Y
Department of Virology, Tohoku University Graduate School of Medicine.
Koyanagi
Yoshio
Y
D002467:Cell Nucleus / Q000378:metabolism; D004279:DNA, Viral / Q000378:metabolism; D019427:HIV Integrase / Q000502:physiology; D015497:HIV-1 / Q000235:genetics / Q000254:growth & development*; D025801:Ubiquitin / Q000502:physiology; D014617:Vacuoles / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism; D014779:Virus Replication
D004279:DNA, Viral; D025801:Ubiquitin; D014764:Viral Proteins; D019427:HIV Integrase