title: Recent advances in vaccines against viral haemorrhagic fevers.
abstract: Development of vaccines against viral haemorrhagic fevers is a public health priority. Recent advances in our knowledge of pathogenesis and of the immune responses elicited by these viruses emphasize the crucial role of the immune system in the control of infection, but also its probable involvement in pathogenesis. Several vaccine candidates against viral haemorrhagic fevers have been evaluated in animals during the past year. Together, these data suggest that a vaccine approach against viral haemorrhagic fevers is feasible, should induce well-balanced immune responses with cellular and humoral components, and should avoid the potential deleterious effects that are associated with such immune responses.
authors.affiliation: Unit of Biology of Emerging Viral Infections, Mérieux-Pasteur Research Centre, Lyon, France.
authors.forename: S
authors.initials: S
authors.lastname: Baize
authors.forename: P
authors.initials: P
authors.lastname: Marianneau
authors.forename: M C
authors.initials: MC
authors.lastname: Georges-Courbot
authors.forename: V
authors.initials: V
authors.lastname: Deubel
mesh_terms: D003716:Dengue Virus / Q000276:immunology; D029043:Ebolavirus / Q000276:immunology; D006482:Hemorrhagic Fevers, Viral / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007836:Lassa virus / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D022341:Yellow Fever Vaccine / Q000276:immunology
chemical_list: D014765:Viral Vaccines; D022341:Yellow Fever Vaccine