[Genetic aspects of Alzheimer disease].
BACKGROUND
To supply relevant information about the genetics of Alzheimer's disease.


METHODS
Data from the literature (Medline) and personal experiences.


RESULTS
Two well-known risks for developing Alzheimer's disease are established: advanced age and genetic factors. Mutations linked to autosomal dominant familial Alzheimer's disease are known in chromosomes 21, 14 and 1. A non-mendelian Alzheimer's disease with complex aetiology is linked to the apolipoprotein E in chromosome 19.


CONCLUSIONS
Children of patients with Alzheimer's disease have a three to four fold increased risk of developing the disease compared to a person without a parent with Alzheimer's disease. The diagnostic benefit of apolipoprotein E genotyping is still uncertain.
Øksengård
Anne Rita
AR
Nasjonalt kompetansesenter for aldersdemens Geratrisk avdeling Ullevål universitetssykehus 0407 Oslo. a.r.h.oksengard@ioks.uio.no
Engedal
Knut
K
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D005260:Female; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D018433:Twin Studies as Topic
D001057:Apolipoproteins E