title: Long-term follow-up of a patient with cutaneous vasculitis secondary to mixed cryoglobulinaemia and hepatitis C virus.
abstract: We describe the clinical course of a patient with mixed cryoglobulinaemia and multisystem disease over a 21-year period. She consistently tested negative for hepatitis C virus (HCV) serology, but active HCV infection (genotype Ia) was confirmed using reverse transcription-polymerase chain reaction. After initial improvement following treatment with interferon-alpha and ribavirin, unfortunately she developed severe neutropenia necessitating discontinuation of both drugs within 4 weeks. She died 1 month later.
authors.affiliation: Department of Dermatology and Histopathology, The Middlesex and University College Hospitals, London, UK. natashakapur3@hotmail.com
authors.forename: N
authors.initials: N
authors.lastname: Kapur
authors.forename: P
authors.initials: P
authors.lastname: Tympanidis
authors.forename: C
authors.initials: C
authors.lastname: Colville
authors.forename: R C
authors.initials: RC
authors.lastname: Yu
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003449:Cryoglobulinemia / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D017445:Skin Diseases, Vascular / Q000209:etiology* / Q000473:pathology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000209:etiology*
chemical_list: D000998:Antiviral Agents