title: [Amoxicillin-clavulanic acid induced hepatotoxicity with progression to cirrhosis].
abstract: Amoxicillin-clavulanic acid is a commonly used antibiotic in clinical practice. It is usually prescribed on an empirical basis and several cases of hepatotoxicity with cholestasis have been described. We report the case of a 42-year-old man who developed an acute hepatocellular lesion with progression to cirrhosis. The patient received amoxicillin-clavulanic acid twice with an interval of four months. Other causes of hepatic failure were excluded. Although amoxicillin-clavulanic acid-induced hepatotoxicity has been widely documented, there are no other reports describing its progression to cirrhosis in an adult.
authors.affiliation: Servicio de Aparato Digestivo, Hospital Torrecárdenas, Almería, Spain. teresa.jordan@terra.es
authors.forename: T
authors.initials: T
authors.lastname: Jordán
authors.forename: M
authors.initials: M
authors.lastname: González
authors.forename: M
authors.initials: M
authors.lastname: Casado
authors.forename: J F
authors.initials: JF
authors.lastname: Suárez
authors.forename: F
authors.initials: F
authors.lastname: Pulido
authors.forename: E
authors.initials: E
authors.lastname: Guerrero
authors.forename: J
authors.initials: J
authors.lastname: Esteban
mesh_terms: D000328:Adult; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000209:etiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology*; D008297:Male
chemical_list: D019980:Amoxicillin-Potassium Clavulanate Combination