Simultaneous EEG-Correlated Ictal fMRI.
The ability to continuously acquire simultaneous EEG and fMRI data during seizures presents a formidable challenge both clinically and technically. Published ictal fMRI reports have so far been unable to benefit from simultaneous electrographic recordings and remain largely assumptive. Unique findings from a Continuous EEG-correlated fMRI experiment are presented in which a focal subclinical seizure was captured in its entirety. For the first time dynamic and biphasic Blood Oxygen Level Dependent (BOLD) signal changes are shown using statistical parametric mapping time-locked to the ictal EEG activity localizing seizure generation and propagation sites, with millimeter resolution, to electroclinically concordant gray matter structures. Though presently of limited clinical applicability, a new avenue is opened for further research.
Salek-Haddadi
Afraim
A
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, United Kingdom.
Merschhemke
Martin
M
Lemieux
Louis
L
Fish
David R
DR
D001931:Brain Mapping; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology* / Q000503:physiopathology*; D004830:Epilepsy, Tonic-Clonic / Q000473:pathology / Q000503:physiopathology; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D013686:Telemetry
D010100:Oxygen