Pregnancy and delivery in a patient with metastatic embryonal sarcoma of the liver.
BACKGROUND
Embryonal sarcoma of the liver is a rare undifferentiated mesenchymal neoplasm with a grave prognosis.


METHODS
We report a spontaneous uneventful pregnancy in a young woman with recurrent metastatic embryonal sarcoma of the liver after hepatectomy (twice) and radiochemotherapy. The patient chose to continue pregnancy despite her general condition and possible hazards to maternal and fetal well-being. She gave birth to a full-term healthy infant. Her disease recurred shortly after the delivery.


CONCLUSIONS
According to a computerized search of the National Library of Medicine database, from 1966 to present, using the search terms "embryonal (or undifferentiated) sarcoma" and "liver" without language restrictions, this is the first reported case of pregnancy and delivery in a patient with embryonal sarcoma of the liver. It illustrates the clinical and ethical dilemmas associated with this complicated condition.
Shufaro
Yoel
Y
Department of Obstetrics and Gynecology, Oncology, Pathology, Hadassah University Hospital, Ein-Kerem, Jerusalem, Israel. yoels@md.huji.ac.il
Uzieli
Beatrice
B
Pappo
Orit
O
Abramov
Yoram
Y
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000628:therapy*; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology / Q000628:therapy*; D011256:Pregnancy Outcome; D012509:Sarcoma / Q000473:pathology* / Q000628:therapy*; D012888:Skull Neoplasms / Q000556:secondary* / Q000628:therapy*