Calciphylaxis in a patient with rheumatoid arthritis without renal failure and hyperparathyroidism: the possible role of long-term steroid use and protein S deficiency.
Calciphylaxis is a rare and life-threatening condition of progressive cutaneous necrosis secondary to small and medium-sized vessel calcification that is seen almost exclusively in patients with end-stage renal disease and hyperparathyroidism. We report a case of calciphylaxis that may very well be due to a long-term steroid use in a rheumatoid arthritis patient who had neither end-stage renal disease nor hyperparathyroidism. We also discuss the possible role of protein S deficiency as a contributing factor.
Korkmaz
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C
Medical School of Osmangazi University, Eskişehir, Turkey. ckorkmaz@ogu.edu.tr
Dündar
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E
Zubaroğlu
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I
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D002115:Calciphylaxis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D018455:Protein S Deficiency / Q000150:complications*; D011859:Radiography; D013256:Steroids / Q000009:adverse effects*
D013256:Steroids