Current progress on esterases: from molecular structure to function.
This article reports on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 2001 Experimental Biology meeting. Current developments in molecular-based studies into the structure and function of cholinesterases, carboxylesterases, and paraoxonases are described. This article covers mechanisms of regulation of gene expression of the various esterases by developmental factors and xenobiotics, as well as the interplay between physiological and chemical regulation of enzyme activity.
Satoh
Tetsuo
T
Biomedical Research Institute, Chiba University, Chiba, Japan.
Taylor
Palmer
P
Bosron
William F
WF
Sanghani
Sonal P
SP
Hosokawa
Masakiyo
M
La Du
Bert N
BN
D000818:Animals; D004950:Esterases / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D019143:Evolution, Molecular; D020869:Gene Expression Profiling; D006801:Humans; D009928:Organ Specificity; D004364:Pharmaceutical Preparations / Q000378:metabolism; D017510:Protein Folding; D013379:Substrate Specificity
D004364:Pharmaceutical Preparations; D004950:Esterases