title: [A transient increase in CCK mRNA levels in amygdala following audiogenic seizures in audiogenic seizure-prone rats].
abstract: The effects of single and multiple seizures on cholecystokinin (CCK) mRNA levels in amygdala of audiogenic seizure-prone rats (P77PMC) were examined by in situ hybridization. The main results are as follows: (1) CCK mRNA positive neurons (No/0.01 mm(2)) in amygdala showed a transient increase in number from the 8+/-1 to 58+/-5 (P<0.01) in 30 min and then returned to the control value in 2 h (9+/-2, P>0.05), and (2) in the multiple consecutive seizure rats the increase in 30 min (22+/-3) was less than that in the single seizure rats (P<0.01), and the number returned to normal in 1 h (6+/-1, P>0.05). These data indicate that the transient increase in CCK mRNA level in amygdala following single or multiple consecutive seizures of P77PMC may be involved in anti-convulsant mechanisms in response to acute seizures.
authors.affiliation: Departments of Physiology, Qingdao University, Qingdao 266021, China.
authors.forename: H
authors.initials: H
authors.lastname: Ni
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.forename: M
authors.initials: M
authors.lastname: Tang
authors.forename: S B
authors.initials: SB
authors.lastname: wang
mesh_terms: D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D002766:Cholecystokinin / Q000096:biosynthesis* / Q000235:genetics; D020195:Epilepsy, Reflex / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D012333:RNA, Messenger; D002766:Cholecystokinin