Elastic fibers: building bridges between cells and their matrix.
Extracellular elastic fibers confer resilience and flexibility to tissues. Recent studies have identified a protein, fibulin-5, that connects these fibers to cells and regulates their assembly and organization.
Midwood
Kim S
KS
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014, USA. kmidwood@molbio.princeton.edu
Schwarzbauer
Jean E
JE
D000818:Animals; D001011:Aorta / Q000648:ultrastructure; D004285:Dogs; D004547:Elastic Tissue / Q000378:metabolism*; D004549:Elastin / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D020894:Microfibrils / Q000378:metabolism; D011485:Protein Binding; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism*; D014333:Tropoelastin / Q000378:metabolism
D016326:Extracellular Matrix Proteins; C492373:FBLN5 protein, human; C120769:Fbln5 protein, mouse; D016023:Integrins; D011994:Recombinant Proteins; D014333:Tropoelastin; D004549:Elastin