Acid-catalyzed formation of hexahomooxacalix[3]arenes.
The role of acid catalysis in oxacalix[3]arene synthesis has been investigated. A range of acids were used to optimize the yield of tert-butyloxacalix[3]arene, the most efficient being p-toluenesulfonic acid, which, with local symmetry complementary with that of the lower rim of the calixarene, provides a templating effect.
Miah
Mijan
M
School of Pharmacy and Biomolecular Science, University of Brighton, Brighton BN2 4GJ, UK.
Romanov
Nikolai N
NN
Cragg
Peter J
PJ