title: Quality of life in patients undergoing ileal pouch-anal anastomosis at the University of Cincinnati.
abstract: BACKGROUND
  In 1978, Drs. Fischer and Martin were among the first to preserve anorectal continence and create a pelvic reservoir in adult patients, in what has become the ileal pouch-anal anastomosis (IPAA).
  
  
  METHODS
  Here we review our institutions' experience with 379 of these procedures from 1978 to present. To assess the specific health concerns of patients with ulcerative colitis (UC) and familial adenomatous polyposis (FAP) and determine the effects of IPAA on health-related quality of life, we evaluated patients with the SF-36, the Rating Form of Inflammatory Bowel Disease Patient Concerns (RFIPC), time trade-off questions, and a gamble question.
  
  
  RESULTS
  IPAA patients did not differ from the general population in seven of eight general health categories assessed by the SF-36. When compared with the UC population as a whole using the RFIPC they had reduced concerns in almost all areas. In addition, time trade-off and gamble questions indicated that these patients, as a group, are willing to accept a significant risk of dying in order to achieve their results of the IPAA.
  
  
  CONCLUSIONS
  This high level of satisfaction has led to the referral of patients who would not have otherwise considered a procedure requiring permanent ileostomy.
authors.affiliation: Department of Surgery, University of Cincinnati Medical Center, Cincinnati, Cincinnati, Ohio 45267, USA.
authors.forename: Bruce
authors.initials: B
authors.lastname: Robb
authors.forename: Timothy
authors.initials: T
authors.lastname: Pritts
authors.forename: Gyu
authors.initials: G
authors.lastname: Gang
authors.forename: Brad
authors.initials: B
authors.lastname: Warner
authors.forename: Connie
authors.initials: C
authors.lastname: Seeskin
authors.forename: Marilyn
authors.initials: M
authors.lastname: Stoops
authors.forename: Laura
authors.initials: L
authors.lastname: James
authors.forename: Janice
authors.initials: J
authors.lastname: Rafferty
authors.forename: Richard
authors.initials: R
authors.lastname: Azizkhan
authors.forename: Lester
authors.initials: L
authors.lastname: Martin
authors.forename: Michael
authors.initials: M
authors.lastname: Nussbaum
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001003:Anal Canal / Q000601:surgery*; D000714:Anastomosis, Surgical; D003093:Colitis, Ulcerative / Q000601:surgery; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D016737:Proctocolectomy, Restorative / Q000523:psychology* / Q000639:trends; D011788:Quality of Life; D011795:Surveys and Questionnaires