Perivascular nerves and vascular endothelium: recent advances.
Within the last few years, advances have been made regarding perivascular nerves and the endothelium of the vascular system, both potentially important in the understanding of the mechanisms of local control of blood flow. Endothelin-1 (ET-1) has been identified in rat cerebrovascular nerves, neuropeptide Y (NPY) has been demonstrated in umbilical endothelium, the arginine-vasopressin (VP) system has been discovered in the heart (including coronary endothelium), and P2X receptors have been observed in vascular endothelial cells. After a brief introduction to vascular biology, this review will focus on the above-mentioned new data.
Loesch
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Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, UK. a.loesch@ucl.ac.uk
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D019332:Endothelin-1 / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000294:innervation* / Q000378:metabolism; D006801:Humans; D009478:Neuropeptide Y / Q000378:metabolism*; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D058469:Receptors, Purinergic P2X
D019332:Endothelin-1; D009478:Neuropeptide Y; D018048:Receptors, Purinergic P2; D058469:Receptors, Purinergic P2X; D001127:Arginine Vasopressin