title: 2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations.
abstract: Replacement of adenine by 2,6-diaminopurine-two nucleobases to be considered equivalent from an etiological point of view-strongly enhances the stability of TNA/TNA, TNA/RNA, or TNA/DNA duplexes and efficiently accelerates template-directed ligation of TNA ligands. [reaction: see text]
authors.affiliation: The Skaggs Institute for Chemical Biology at the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Wu
authors.forename: Guillermo
authors.initials: G
authors.lastname: Delgado
authors.forename: Ramanarayanan
authors.initials: R
authors.lastname: Krishnamurthy
authors.forename: Albert
authors.initials: A
authors.lastname: Eschenmoser
mesh_terms: D015075:2-Aminopurine / Q000031:analogs & derivatives* / Q000737:chemistry*; D020029:Base Pairing; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry; D005663:Furans / Q000737:chemistry*; D008024:Ligands; D013058:Mass Spectrometry; D009841:Oligonucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013698:Templates, Genetic
chemical_list: D005663:Furans; D008024:Ligands; D009841:Oligonucleotides; D015075:2-Aminopurine; C007300:2,6-diaminopurine; D012313:RNA; D004247:DNA