title: Strategies in lead selection and optimization: application of a graphical model and automated in vitro ADME screening.
authors.affiliation: Parke-Davis Pharmaceutical Research, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. arun.mandagere@wl.com
authors.forename: A K
authors.initials: AK
authors.lastname: Mandagere
mesh_terms: D000818:Animals; D001331:Automation; D002460:Cell Line; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D006801:Humans; D006863:Hydrogen-Ion Concentration; D020128:Inhibitory Concentration 50; D007700:Kinetics; D010599:Pharmacokinetics; D013045:Species Specificity
chemical_list: D003577:Cytochrome P-450 Enzyme System