Overexpression of the Escherichia coli sugE gene confers resistance to a narrow range of quaternary ammonium compounds.
SugE of Escherichia coli, first identified as a suppressor of groEL mutations but a member of the small multidrug resistance family, has not previously been shown to confer a drug resistance phenotype. We show that high-level expression of sugE leads to resistance to a subset of toxic quaternary ammonium compounds.
Chung
Yong Joon
YJ
Division of Biology, University of California at San Diego, La Jolla, California 92093-0116, USA.
Saier
Milton H
MH
D001426:Bacterial Proteins / Q000378:metabolism*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects*; D008565:Membrane Proteins; D008826:Microbial Sensitivity Tests; D018832:Molecular Chaperones; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D018832:Molecular Chaperones; D000644:Quaternary Ammonium Compounds; C080403:sugE protein, E coli