[Status of hereditary hypercoagulability and cerebral venous thrombosis. Report of 3 cases].
Hereditary hypercoagulability has been identified as risk factor in approximately 30% of cerebral venous thrombosis cases. We report three females with this association. A 38 years old female with a history of deep venous thrombosis of the lower limb, presented with headache, vomiting and a generalized seizure. Magnetic resonance angiography showed a partial thrombosis of the left lateral and superior longitudinal venous sinuses. Coagulation study showed a resistance to activated C protein and factor V Leyden. A 42 years old woman with a history of deep venous thrombosis, presented a right hemiplegia during a hospitalization. Magnetic resonance showed a left lateral hemorrhagic infarction. Magnetic resonance angiography showed an absence of signal in three venous sinuses. Coagulation study showed a protein C deficiency. A 17 years old woman presented a right hemiparesis in the sixth day of puerperium. CAT scan showed a left frontoparietal subcortical venous infarction. Coagulation study showed an antithrombin III deficiency.
Guevara
Carlos
C
Departamento de Neurología, Facultad de Medicina, Campus Sur, Universidad de Chile, Hospital Barros Luco-Trudeau. rebecarlos@hotmail.com
Nogales-Gaete
Jorge
J
Figueroa
Tatiana
T
Sáez
David
D
Valenzuela
Daniel
D
D020016:Activated Protein C Resistance / Q000150:complications / Q000235:genetics; D000293:Adolescent; D000328:Adult; D025861:Blood Coagulation Disorders, Inherited / Q000150:complications* / Q000235:genetics; D002543:Cerebral Hemorrhage / Q000097:blood / Q000209:etiology; D002544:Cerebral Infarction / Q000097:blood / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020767:Intracranial Thrombosis / Q000097:blood / Q000209:etiology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D020246:Venous Thrombosis / Q000097:blood / Q000209:etiology* / Q000628:therapy