Total synthesis of (-)-callystatin A.
A total synthesis of the cytotoxic polyketide marine natural product callystatin A is described. The route features chiral allenylmetal additions to construct the polypropionate C15-22 segment and an sp(2)-sp(3) Suzuki coupling to join the C1-C11 and C12-C22 subunits.
Marshall
James A
JA
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA. jam5x@virginia.edu
Bourbeau
Matthew P
MP
D000818:Animals; D001685:Biological Factors / Q000138:chemical synthesis*; D002384:Catalysis; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001685:Biological Factors; D005231:Fatty Acids, Unsaturated; C421091:callystatin A