Adenosine A1 receptor antagonists in the kidney: effects in fluid-retaining disorders.
Adenosine A(1) receptor antagonists have been used effectively as potassium-sparing and renal-function-protective diuretics in new studies. In addition, the role of adenosine--acting through adenosine A(1) receptors--in renal autoregulation has been clarified. Finally, the application of adenosine receptor antagonists has been implicated in protection from acute renal failure associated with radiocontrast media treatment.
Welch
William J
WJ
Georgetown University, Department of Medicine, Building D-395, 4000 Reservoir Road, Washington, DC 20007, USA. welchw@georgetown.edu
D000818:Animals; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology; D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1 / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000187:drug effects* / Q000502:physiology
D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1