title: Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases.
abstract: We investigated the occurrence of T cells in the brain parenchyma of Alzheimer's disease (AD), non-AD degenerative dementias and controls by semi-quantitative analysis of immunohistochemically stained tissue sections. In all cases, we found at least some T cells. The number of T cells was increased in the majority of AD cases compared with other cases. The phenotype of T cells in the AD brain indicates that they are activated but are not fully differentiated. Antigen-triggered clonal expansion is not likely to take place. Local inflammatory conditions might cause accumulation and activation of T cells in the AD brain.
authors.affiliation: Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Togo
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Akiyama
authors.forename: Eizo
authors.initials: E
authors.lastname: Iseki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kondo
authors.forename: Kenji
authors.initials: K
authors.lastname: Ikeda
authors.forename: Masanori
authors.initials: M
authors.lastname: Kato
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Oda
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Kenji
authors.initials: K
authors.lastname: Kosaka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000276:immunology* / Q000473:pathology; D001921:Brain / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000276:immunology* / Q000473:pathology; D010641:Phenotype; D013601:T-Lymphocytes