Cultured autografting for juvenile myelomonocytic leukaemia.
A case of juvenile myelomonocytic leukaemia (JMML) associated with a chromosomal translocation (1;5) is described. Initial cytoreductive therapy failed to control the disease. In the absence of a matched family or unrelated donor, a Dexter-type long-term bone marrow culture (LTBMC) was established. The LTBMC showed preferential growth of normal stem cells over the abnormal clone, allowing a cultured autologous stem cell transplantation to be performed. Despite detection of the t(1;5) from 5 months to 7 years following cultured autograft, the patient remained in haematological remission. Currently the patient is alive and well at 10 years in full cytogenetic remission.
Grainger
John D
JD
Royal Manchester Children's Hospital, Hospital Road, Pendlebury, Manchester M27 4HA, UK.
Will
Andrew M
AM
Stevens
Richard F
RF
D001854:Bone Marrow Cells / Q000473:pathology; D018929:Cell Culture Techniques / Q000379:methods; D002878:Chromosomes, Human, Pair 1; D002895:Chromosomes, Human, Pair 5; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D012074:Remission Induction; D013234:Stem Cells / Q000473:pathology; D014178:Translocation, Genetic; D014182:Transplantation, Autologous