title: Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors.
abstract: Protein kinase A (PKA) and neuronal nitric oxide synthase (nNOS) are important signaling molecules. It is well known that PKA can specifically phosphorylate nNOS. But the underlying molecular mechanism is still obscure. Our data indicate that the protein inhibitor of nNOS (PIN) binds to protein kinase A inhibitors (PKIs), which suggests that PKIs, together with PIN, might mediate the phosphorylation of nNOS by PKA.
authors.affiliation: State Key Laboratory of Genetics Engineering, Institute of Genetics, School of Life Science, Fudan University, 220 Handan Road, Shanghai 200433, PR China.
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Yu
authors.forename: Long
authors.initials: L
authors.lastname: Yu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chen
authors.forename: Lihua
authors.initials: L
authors.lastname: Zheng
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Chen
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Daming
authors.initials: D
authors.lastname: Ren
authors.forename: Shouyuan
authors.initials: S
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002478:Cells, Cultured; D002490:Central Nervous System / Q000201:enzymology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D029721:Drosophila Proteins; D004398:Dyneins; D017930:Genes, Reporter / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D026602:Nitrergic Neurons / Q000201:enzymology*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction / Q000235:genetics; D009435:Synaptic Transmission / Q000502:physiology*; D020798:Two-Hybrid System Techniques; D015003:Yeasts / Q000201:enzymology
chemical_list: D002352:Carrier Proteins; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; C015482:protein kinase modulator; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D017868:Cyclic AMP-Dependent Protein Kinases; D004398:Dyneins