Altered sexual and social behaviors in trp2 mutant mice.
We have used gene targeting to generate mice with a homozygous deficiency in trp2, a cation channel expressed in the vomeronasal organ (VNO). Trp2 mutant animals reveal a striking reduction in the electrophysiological response to pheromones in the VNO, suggesting that trp2 plays a central role in mediating the pheromone response. These mutants therefore afford the opportunity to examine the role of the VNO in the generation of innate sexual and social behaviors in mice. Trp2 mutant males and nursing females are docile and fail to initiate aggressive attacks on intruder males. Male-female sexual behavior appears normal, but trp2 mutant males also vigorously mount other males. These results suggest that the cation channel trp2 is required in the VNO to detect male-specific pheromones that elicit aggressive behaviors and dictate the choice of sexual partners.
Leypold
Bradley G
BG
Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Yu
C Ron
CR
Leinders-Zufall
Trese
T
Kim
Michelle M
MM
Zufall
Frank
F
Axel
Richard
R
D000374:Aggression; D000818:Animals; D004594:Electrophysiology; D005260:Female; D017353:Gene Deletion; D006720:Homozygote; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D010675:Pheromones; D012737:Sex Factors; D012726:Sexual Behavior, Animal; D050052:TRPC Cation Channels; D019147:Vomeronasal Organ / Q000502:physiology
D008565:Membrane Proteins; D010675:Pheromones; D050052:TRPC Cation Channels; C113139:Trp2 protein, vertebrate; C491858:Trpc2 protein, mouse