The T-cell receptor signalosome: a dynamic structure with expanding complexity.
Signal transduction in T cells is a dynamic process involving a large number of membrane and cytosolic proteins. The TCR macromolecular complex (signalosome) is initiated by receptor occupancy and becomes more elaborate over time. This review describes how 'vertical' displacement mechanisms and lateral coalescence of lipid-raft-associated scaffold proteins combine to form distinct signalosomes, which control signal specificity.
Werlen
Guy
G
Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital-Basel, Hebelstrasse 20, CH-4031, Basel, Switzerland. guy.werlen@unibas.ch
Palmer
Ed
E
D000818:Animals; D017252:CD3 Complex / Q000737:chemistry / Q000502:physiology; D006801:Humans; D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000502:physiology*
D017252:CD3 Complex; D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell