title: The cytoplasmic face of cell contact sites.
abstract: The cytoplasmic face of cell contact sites comprises large macromolecular assemblies that link transmembrane cell adhesion molecules to the cytoskeleton. These assemblies are dynamic structures that are the targets of regulatory signals that control cell adhesiveness. Recent studies of the biochemistry and structure of the cadherin-catenin complex, vinculin and proteins of the ezrin/radixin/moesin family have begun to reveal the architecture of these assemblies and the mechanisms that are involved in their regulation.
authors.affiliation: Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, California 94305, USA.
authors.forename: Sabine
authors.initials: S
authors.lastname: Pokutta
authors.forename: William I
authors.initials: WI
authors.lastname: Weis
mesh_terms: D022005:Adherens Junctions / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D001798:Blood Proteins / Q000737:chemistry / Q000378:metabolism; D015820:Cadherins / Q000737:chemistry* / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology*; D003593:Cytoplasm / Q000737:chemistry / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008840:Microfilament Proteins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D015534:Trans-Activators / Q000737:chemistry* / Q000378:metabolism; D016596:Vinculin / Q000737:chemistry* / Q000378:metabolism; D051176:beta Catenin; D000099149:Ezrin
chemical_list: D001798:Blood Proteins; D015820:Cadherins; D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D010750:Phosphoproteins; D015534:Trans-Activators; D016596:Vinculin; D051176:beta Catenin; D000099149:Ezrin; C495270:CTNNB1 protein, human; C071058:moesin; C071776:radixin