[Effect and mechanism of action of Tinospora bakis roots on biliary secretion using in vivo models].
The aim of this study is to determine the choleretic properties of lyophilized aqueous extract of Tinospora bakis roots. For thus, we have used healthy and cholestatic Wistar rats. After administration of the extract (4 mg/100 g of weight) biliary flow, biliary acids flow, biliary glutathione and glucose concentrations were measured by specific methods. Comparative results between treated rats and non treated rats show: For healthy rats: a significant increase of biliary flow, biliary acids flow in the group of treated rats versus non treated healthy rats. There were no significant difference in the glutathione and glucose concentrations. For cholestatic rats: we noted also significant increase of biliary flow, biliary acids flow and glutathione concentration in the treated rats group. These results suggest that Tinospora bakis has a choleretic effect in vivo which depends on biliary acids and/or glutathione concentration.
Diallo Sall
A
A
Guèye
M
M
Sarr
M
M
N'Diaye
A K
AK
N'Diaye
M
M
Faye
B
B
D000818:Animals; D001646:Bile / Q000737:chemistry / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism*; D002252:Carbon Tetrachloride Poisoning / Q000150:complications; D002756:Cholagogues and Choleretics / Q000494:pharmacology* / Q000627:therapeutic use; D002779:Cholestasis / Q000188:drug therapy* / Q000209:etiology; D004353:Drug Evaluation, Preclinical; D005704:Gallbladder / Q000187:drug effects* / Q000378:metabolism; D005947:Glucose / Q000032:analysis; D005978:Glutathione / Q000032:analysis; D008297:Male; D016488:Medicine, African Traditional; D023421:Models, Animal; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012636:Secretory Rate / Q000187:drug effects; D014867:Water
D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D010936:Plant Extracts; D014867:Water; D005978:Glutathione; D005947:Glucose