Nitric oxide release from coumarin 4-carboxamidoximes in the presence of thiols.
Coumarin 4-carboxamides with potent anti-inflammatory activity were studied for nitric oxide release in the presence of thiol cofactors in vitro. It was found that NO2- release was dependent on the nature of thiol.
Kontogiorgis
Christos A
CA
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki, Greece.
Hadjipavlou-Litina
Dimitra J
DJ
D003374:Coumarins / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry*; D026423:S-Nitroso-N-Acetylpenicillamine / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D003374:Coumarins; D020030:Nitric Oxide Donors; D013438:Sulfhydryl Compounds; D009569:Nitric Oxide; D026423:S-Nitroso-N-Acetylpenicillamine; D003545:Cysteine