title: Effect of obesity and insulin on immunity in non-insulin-dependent diabetes mellitus.
abstract: OBJECTIVE
  To understand the effect of obesity and insulin on immune functions in non-insulin-dependent diabetes mellitus (NIDDM).
  
  
  METHODS
  Fourteen obese NIDDM (body mass index (BMI)=30.6+/-1.1), seven non-obese NIDDM (BMI=24.2+/-0.5) and five obese non-NIDDM (BMI=28.3+/-0.67).
  
  
  METHODS
  We first examined the influence of insulin on the proliferation of several human cell lines. Second, we compared several immune functions between obese and non-obese NIDDM, and obese non-NIDDM patients using peripheral blood mononuclear cells.
  
  
  RESULTS
  Insulin decreased proliferation of T-cell lines but not that of other types of cell lines. Furthermore, obesity augmented the production of IL-1beta which could have cytotoxity against islet beta cells in NIDDM.
  
  
  CONCLUSIONS
  Our data suggested that the pathophysiology of NIDDM could be affected by the change of immunity due to obesity, and the treatment of obesity in NIDDM may be important from an immunological aspect.
authors.affiliation: Japan Women's University, The Division of Clinical Nutrition, Tokyo, Japan. g9951004@jwu.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Mito
authors.forename: T
authors.initials: T
authors.lastname: Hiyoshi
authors.forename: T
authors.initials: T
authors.lastname: Hosoda
authors.forename: C
authors.initials: C
authors.lastname: Kitada
authors.forename: K
authors.initials: K
authors.lastname: Sato
mesh_terms: D000704:Analysis of Variance; D003920:Diabetes Mellitus / Q000097:blood / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin / Q000276:immunology*; D007375:Interleukin-1 / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000502:physiology; D008875:Middle Aged; D009765:Obesity
chemical_list: D007328:Insulin; D007375:Interleukin-1