title: [Levels and clinical significance of CD44 (intron 9) and CD44v6 in malignant cerebroma].
abstract: OBJECTIVE
  To investigate the expression of CD44 (intron 9) and CD44v6 in brain neoplasm.
  
  
  METHODS
  CD44 (intron 9) and CD44v6 were detected in malignant meningoma, encephalic glioma, and normal encephalic tissues around the brain noeplasm respectively by using RT-PCR.
  
  
  RESULTS
  The positive expression rate of CD44v6 was 92.86% (26/28) in malignant meningoma and 88.0% (22/25) in encephalic glioma. They were significantly higher than 5.0% (1/20) in normal encephalic tissues (P < 0.01). Mass values of malignant meningoma and encephalic glioma were higher than that of normal encephalic tissues (P < 0.01). The expression of CD44 (intron 9) was higher in malignant meningoma and encephalic glioma than in normal encephalic tissues (P < 0.01).
  
  
  CONCLUSIONS
  Detection of CD44 (intron 9) and CD44v6 might be helpful to the diagnosis of malignant cerebroma.
authors.affiliation: Major Laboratory of Congenital Malformative Research, Health Ministry, Second Affiliated Hospital, China Medical University, Shenyang 110004, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Gao
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006023:Glycoproteins / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis* / Q000235:genetics; D007438:Introns / Q000235:genetics; D008875:Middle Aged; D012333:RNA, Messenger / Q000096:biosynthesis
chemical_list: C112697:CD44v6 antigen; D006023:Glycoproteins; D018960:Hyaluronan Receptors; D012333:RNA, Messenger