title: Anatomic and functional characteristics of the rat ileal pouch.
abstract: BACKGROUND
  The definitive operation for chronic ulcerative colitis (UC) and familial adenomatous polyposis is total proctocolectomy with ileal pouch-anal anastomosis (IPAA). Mild inflammation (pouchitis) is omnipresent in pouches and becomes severe in 50% of UC patients with IPAA. The etiology of pouchitis is likely due to combined genetic, microbial, and immunologic factors. Epithelial cell exposure to surgical trauma and/or to changes in intestinal bacterial composition may account for the inflammatory infiltrate. Progress in understanding pouchitis is restricted by the lack of suitable animal models.
  
  
  METHODS
  An ileal pouch-rectal anastomosis [IPRA] in rats was developed to reproduce a model of human IPAA and clinical, gross and histologic criteria were determined.
  
  
  RESULTS
  Many shared features with human ileal pouch were observed.
  
  
  CONCLUSIONS
  IPRA is an important in vivo model to study mechanisms of repair, defense and immunity that may contribute to pouchitis.
authors.affiliation: Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Chiung-Nien
authors.initials: CN
authors.lastname: Chen
authors.forename: Laila D
authors.initials: LD
authors.lastname: McVay
authors.forename: Zubin S
authors.initials: ZS
authors.lastname: Batlivala
authors.forename: Samantha K
authors.initials: SK
authors.lastname: Hendren
authors.forename: Gary P
authors.initials: GP
authors.lastname: Swain
authors.forename: Nita
authors.initials: N
authors.lastname: Salzman
authors.forename: Noel N
authors.initials: NN
authors.lastname: Williams
authors.forename: John L
authors.initials: JL
authors.lastname: Rombeau
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D004195:Disease Models, Animal; D007082:Ileum / Q000473:pathology* / Q000601:surgery; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008643:Mesentery; D009929:Organ Size; D010581:Peyer's Patches / Q000473:pathology; D019449:Pouchitis / Q000209:etiology / Q000473:pathology*; D016737:Proctocolectomy, Restorative; D051381:Rats; D017207:Rats, Sprague-Dawley; D012007:Rectum / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate; D013997:Time Factors