title: Harmful effects of dietary salt in addition to hypertension.
abstract: In addition to raising the blood pressure dietary salt is responsible for several other harmful effects. The most important are a number which, though independent of the arterial pressure, also harm the cardiovascular system. A high salt intake increases the mass of the left ventricle, thickens and stiffens conduit arteries and thickens and narrows resistance arteries, including the coronary and renal arteries. It also increases the number of strokes, the severity of cardiac failure and the tendency for platelets to aggregate. In renal disease, a high salt intake accelerates the rate of renal functional deterioration. Apart from its effect on the cardiovascular system dietary salt has an effect on calcium and bone metabolism, which underlies the finding that in post-menopausal women salt intake controls bone density of the upper femur and pelvis. Dietary salt controls the incidence of carcinoma of the stomach and there is some evidence which suggests that salt is associated with the severity of asthma in male asthmatic subjects.
authors.affiliation: Department of Clinical Chemistry, Imperial College of Science, Technology and Medicine, Faculty of Medicine, Charing Cross Hospital, St Dunstan's Road, London W6 8RP, UK. h.dewardener@ic.ac.uk
authors.forename: H E
authors.initials: HE
authors.lastname: de Wardener
authors.forename: G A
authors.initials: GA
authors.lastname: MacGregor
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007674:Kidney Diseases / Q000209:etiology*; D008297:Male; D012982:Sodium, Dietary / Q000009:adverse effects*; D013272:Stomach Diseases / Q000209:etiology*
chemical_list: D012982:Sodium, Dietary