Peptide inhibitors of beta amyloid aggregation.
Amyloid beta peptide (Abeta) is implicated in the pathogenesis of Alzheimer s disease (AD), particularly as oligomers or polymers that are correlated with Abeta cellular toxicity. Inhibition of the formation of toxic forms of Abeta has therefore emerged as one approach to the treatment of AD. This article reviews efforts to adapt the structure of Abeta to the design and testing of peptide-based inhibitors of Abeta polymerization of interest as potential AD therapeutics.
Findeis
Mark A
MA
Praecis Pharmaceuticals Incorporated, 830 Winter Street, Waltham, MA 02451-1420, USA. mark.findeis@praecis.com
D000544:Alzheimer Disease / Q000188:drug therapy*; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors*; D006801:Humans
D016229:Amyloid beta-Peptides