A boy with cutaneous necrosis occurring during treatment with levamisole.
We present a child on long-term treatment with levamisole, and heterozygous for factor V Leiden, who developed cutaneous necrosis associated with formation of p-ANCA and lupus anticoagulant. Symptoms resolved when the levamisole treatment was stopped.
Powell
J
J
Departments of Dermatology and Haematology Royal Berkshire Hospital, Reading, Berkshire, UK. jjphbp@aol.com
Grech
H
H
Holder
J
J
D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D002648:Child; D003875:Drug Eruptions / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D005165:Factor V / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007871:Leg Ulcer / Q000139:chemically induced* / Q000235:genetics / Q000473:pathology; D007978:Levamisole / Q000009:adverse effects*; D008297:Male; D009336:Necrosis; D012867:Skin / Q000473:pathology*
D000276:Adjuvants, Immunologic; C095381:factor V Leiden; D007978:Levamisole; D005165:Factor V