[Change of immunosuppressive acidic protein in sera of patients with pulmonary tuberculosis and its clinical significance].
OBJECTIVE
To investigate the change of immunosuppressive acidic protein (IAP) in sera of patients with pulmonary tuberculosis (TB) and its clinical value.


METHODS
IAP in sera of 336 patients suffering from pulmonary TB and controls was detected by agar diffusion assay.


RESULTS
In pulmonary TB, healthy controls and non-TB respiratory diseases, the level of IAP was (797 +/- 168) mg/L, (367 +/- 71) mg/L and (404 +/- 75) mg/L, respectively. If > 500 mg/L was regarded as positive threshold, the positive rates in the above groups were 96.7%, 9.2% and 9.6%, respectively. IAP positive rates in cases of primary, disseminated, infiltrative, chronic fibro-cavernous pulmonary TB and tuberculous pleuritis were 100, 0%, 100.0%, 96.0%, 98.6% and 96.9%, respectively. IAP was significantly higher in progressive pulmonary TB than in stable pulmonary TB, and was decreased when patients' condition improved after treatment.


CONCLUSIONS
Detection of IAP in sera of patients with pulmonary TB can reflect patients' immunosuppression status and the severity of the disease, and may be useful in assessing treatment effect and evaluating prognosis.
Fei
Xiaofeng
X
The Fifth People's Hospital of Suzhou, Suzhou 215007, China.
Wu
Jianhong
J
Ma
Minhua
M
Fang
Mingjuan
M
D006801:Humans; D009363:Neoplasm Proteins / Q000097:blood*; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000276:immunology
D009363:Neoplasm Proteins; C030193:immunosuppressive acidic protein