Novel targets for the control of secretory diarrhoea.
Secretory diarrhoea continues to be a major clinical problem worldwide. It is now recognised that the enteric nervous system plays an important role in the pathogenesis of enterotoxin mediated intestinal secretion, which has resulted in the identification of novel therapeutic targets for the treatment of acute watery diarrhoea.
Farthing
M J G
MJ
Faculty of Medicine, University of Glasgow, UK. m.farthing@clinmed.gla.ac.uk
D003967:Diarrhea / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D017615:Enteric Nervous System / Q000187:drug effects* / Q000503:physiopathology; D020895:Enterocytes / Q000378:metabolism*; D004768:Enterotoxins / Q000502:physiology*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D015260:Neprilysin / Q000627:therapeutic use; D015282:Octreotide / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000627:therapeutic use; D013373:Substance P / Q000037:antagonists & inhibitors
D004768:Enterotoxins; D012702:Serotonin Antagonists; D013373:Substance P; D015260:Neprilysin; D015282:Octreotide