title: A clinical study of a fibrinogen-based collagen fleece for dural repair in neurosurgery.
abstract: BACKGROUND
  There is frequently a need for dural grafts to cover defects resulting from retraction, shrinkage, or excision following neurosurgical procedures. Many substances have been tried as possible dural substitution, and different tissues and materials have been evaluated for use in dural repair.
  
  
  METHODS
  The authors performed a retrospective review of 288 consecutive neurosurgical procedures using a fibrinogen based collagen fleece (TachoComb), a resorbable mesh of collagen from horse tendons, coated with human fibrinogen, bovine thrombin, bovine aprotinin and riboflavin (for marking the coated side), for dural substitution. The fibrinogen and thrombin imitate the last step of the coagulation cascade. On contact with bleeding wounds or other body fluids the coagulation factors dissolve and a link is formed between the collagen carrier and the wound surface. Thrombin converts fibrinogen into fibrin by splitting off peptides. Aprotinin prevents premature lysis of the fibrin clot by plasmin.
  
  
  RESULTS
  Neither superficial or deep wound infections nor aseptic meningitis were noted. We found good fibrous incorporation of TachoComb into the surrounding normal dura. Postoperative cerebrospinal-fluid (CSF) leaks developed in only five cases, who had to be re-operated, upon as well as one patient with a rebleeding. In another four cases, there was notable subcutaneous cerebrospinal-fluid accumulation without CSF-leak. They required a lumbar cerebrospinal-fluid drainage.
  
  
  CONCLUSIONS
  We conclude that TachoComb is a valuable alternative to the patients fibrous tissues for dural repair in cases in which autogenous tissues are either unavailable or insufficient for proper reconstruction.
authors.affiliation: Department of Neurosurgery, University Clinic of Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Reddy
authors.forename: A
authors.initials: A
authors.lastname: Schöggl
authors.forename: B
authors.initials: B
authors.lastname: Reddy
authors.forename: W
authors.initials: W
authors.lastname: Saringer
authors.forename: G
authors.initials: G
authors.lastname: Weigel
authors.forename: C
authors.initials: C
authors.lastname: Matula
mesh_terms: D007611:Aprotinin; D001927:Brain Diseases / Q000601:surgery; D001932:Brain Neoplasms / Q000601:surgery; D020099:Coated Materials, Biocompatible; D003094:Collagen; D003399:Craniotomy / Q000379:methods*; D004338:Drug Combinations; D004388:Dura Mater / Q000601:surgery*; D005340:Fibrinogen; D005500:Follow-Up Studies; D006488:Hemostasis, Surgical; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology / Q000601:surgery; D011474:Prosthesis Design; D019919:Prosthesis Implantation; D012086:Reoperation; D012189:Retrospective Studies; D013122:Spinal Diseases / Q000601:surgery; D013125:Spinal Neoplasms / Q000601:surgery; D013917:Thrombin; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D004338:Drug Combinations; C093991:tachocomb; D005340:Fibrinogen; D003094:Collagen; D007611:Aprotinin; D013917:Thrombin