title: Pathogenesis of colonic diverticula.
abstract: BACKGROUND
  Diverticula are herniations through the colonic wall and are therefore likely to be due to a weakness within the wall, an alteration in intracolonic pressures or a combination of these factors. This article reviews these aspects in relation to the pathogenesis of colonic diverticula.
  
  
  METHODS
  Medline and Science Citation Index searches were performed to locate English language articles relating to the pathogenesis of colonic diverticulosis published since 1960. Manual cross-referencing was also performed and some historical articles were included.
  
  
  CONCLUSIONS
  Several theories now exist about the development of colonic diverticula. The majority of the evidence suggests that the morphological changes are the response to a lifelong consumption of a low-residue diet. However, there are complex relations between colonic structure, motility and dietary factors, and it is likely that all of these (and possibly genetic influences) play a role in the pathogenesis to a greater or lesser degree.
authors.affiliation: Departments of Surgery and Gastroenterology, University Hospital, Nottingham, UK. j.simpson@nottingham.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Simpson
authors.forename: J H
authors.initials: JH
authors.lastname: Scholefield
authors.forename: R C
authors.initials: RC
authors.lastname: Spiller
mesh_terms: D000367:Age Factors; D003239:Connective Tissue Cells; D004032:Diet / Q000009:adverse effects; D004241:Diverticulum, Colon / Q000209:etiology* / Q000503:physiopathology; D004594:Electrophysiology; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa; D023421:Models, Animal; D009130:Muscle, Smooth; D011312:Pressure; D012307:Risk Factors