Ferritin expression modulates cell cycle dynamics and cell responsiveness to H-ras-induced growth via expansion of the labile iron pool.
Repression or overexpression of ferritin accelerated or retarded cell cycling respectively, via changes in the cellular labile iron pool (LIP). A rise in LIP is caused by ferritin repression enhanced growth, induced by H-ras, and reverted growth arrest is induced by dominant negative H-ras. The studies indicate that repression of ferritin expression provides a mechanism by which certain oncogenes lead to cell growth stimulation.
Kakhlon
Or
O
Department of Biological Chemistry, Institute of Life Sciences, Hebrew University, Jerusalem, 91904, Israel.
Gruenbaum
Yosef
Y
Cabantchik
Z Ioav
ZI
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D019925:Cyclin A / Q000096:biosynthesis; D005293:Ferritins / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology*; D011905:Genes, ras / Q000502:physiology*; D006801:Humans; D007501:Iron / Q000502:physiology*; D020014:K562 Cells; D051379:Mice; D014162:Transfection
D019925:Cyclin A; D005293:Ferritins; D007501:Iron