[A 1:2 matched case-control study on congenital external malformation during perinatal period].
OBJECTIVE
To investigate the risk factors for congenital external malformation.


METHODS
A 1:2 matched case-control study was conducted with 52 cases of congenital external malformation during perinantal period collected from surveillance in Baoan District of Shenzhen City from January to June in 2000.


RESULTS
Simple and multiple conditional logistic regression analysis showed that the major risk factors for congenital external malformations during perinatal period were preterm labor (beta(k) = 1.4171, s(theta, beta(kappa)) = 0.4601, OR = 4.115), adverse mental stimulus (beta(kappa) = 2.1870, s(theta beta(kappa)) = 0.7873, OR = 8.909), taking medicine (beta(k) = 1.9178, s(theta beta(kappa)) = 0.8072, OR = 6.808) and exposure to hazardous chemicals during early pregnancy (beta(k) = 0.9602, s(theta beta(kappa)) = 0.4262, OR = 2.612).


CONCLUSIONS
Congenital external malformation during perinatal period was caused by multiple risk factors and results of the study showed that environmental and mental factors were in obvious connection with its occurrence.
Wu
Taishun
T
Department of Science and Teaching, The Hygiene and Anti-epidemic Station of Baoan District, Shenzhen City, Shenzhen 518101, China.
Li
Songlin
S
Chen
Shupei
S
Wu
Likang
L
Xiao
Jinhui
J
Nie
Shaofa
S
Chen
Wei
W
Zhu
Guibao
G
D016022:Case-Control Studies; D000013:Congenital Abnormalities / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D018743:Perinatal Care; D011247:Pregnancy; D012307:Risk Factors