title: The concept of idiotypic vaccination against factor VIII inhibitors in haemophilia A.
abstract: Idiotypic vaccination has proven successful in several animal models and human trials. Here we suggest that the expression of cross-reactive idiotypes on factor VIII (FVIII) inhibitors of patients with haemophilia A, patients with anti-FVIII autoimmune disease and natural anti-FVIII antibodies of healthy individuals, together with the ability of anti-idiotypic reagents to neutralize anti-FVIII antibodies, provides a rationale for designing a vaccine strategy aimed at preventing the occurrence of or suppressing inhibitors, based on the induction of protective anti-idiotypes. Here we discuss the rationale supporting the concept of using idiotypic vaccination to prevent the occurrence of FVIII inhibitors in patients with haemophilia A.
authors.affiliation: INSERM U 430 and Université Pierre et Marie Curie, Hôpital Broussais, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Lacroix-Desmazes
authors.forename: J
authors.initials: J
authors.lastname: Bayry
authors.forename: N
authors.initials: N
authors.lastname: Misra
authors.forename: S V
authors.initials: SV
authors.lastname: Kaveri
authors.forename: M D
authors.initials: MD
authors.lastname: Kazatchkine
mesh_terms: D000906:Antibodies / Q000276:immunology*; D000917:Antibody Formation; D005169:Factor VIII / Q000037:antagonists & inhibitors / Q000276:immunology*; D006467:Hemophilia A / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D014611:Vaccination; D014612:Vaccines / Q000276:immunology*
chemical_list: D000906:Antibodies; D014612:Vaccines; D005169:Factor VIII