Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag.
A fucoidan consisting of L-fucose, sulfate and acetate in a molar proportion of 1:1.23:0.36 was isolated from the Pacific brown seaweed Fucus evanescens. The structures of its desulfated and de-O-acetylated derivatives were investigated by 1D and 2D (1)H and (13)C NMR spectroscopy, and the data obtained were confirmed by methylation analysis of the native and desulfated polysaccharides. The fucoidan was shown to contain a linear backbone of alternating 3- and 4-linked alpha-L-fucopyranose 2-sulfate residues: -->3)-alpha-L-Fucp(2SO(3)(-))-(1-->4)-alpha-L-Fucp(2SO(3)(-))-(1-->. Additional sulfate occupies position 4 in a part of 3-linked fucose residues, whereas a part of the remaining hydroxyl groups is randomly acetylated.
Bilan
Maria I
MI
N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii prosp. 47, 119991 Moscow, Russian Federation.
Grachev
Alexey A
AA
Ustuzhanina
Nadezhda E
NE
Shashkov
Alexander S
AS
Nifantiev
Nikolay E
NE
Usov
Anatolii I
AI
D000085:Acetates / Q000032:analysis; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D005643:Fucose / Q000032:analysis; D019906:Nuclear Magnetic Resonance, Biomolecular; D000459:Phaeophyceae / Q000737:chemistry*; D011134:Polysaccharides / Q000032:analysis / Q000737:chemistry*; D017421:Sequence Analysis; D013431:Sulfates / Q000032:analysis
D000085:Acetates; D011134:Polysaccharides; D013431:Sulfates; D005643:Fucose; C007789:fucoidan