Cystathionine gamma-synthase and threonine synthase operate in concert to regulate carbon flow towards methionine in plants.
The sulfur-containing amino acid methionine is a nutritionally important essential amino acid and is the precursor of several metabolites that regulate plant growth and responses to the environment. Methionine production is largely regulated by cystathionine gamma-synthase, the first specific enzyme for its synthesis. This enzyme competes in a complex manner with threonine synthase, the last enzyme in threonine biosynthesis, for their common substrate O-phosphohomoserine. New genetic and molecular data suggest that methionine synthesis and catabolism are coordinately regulated by novel post-transcriptional and post-translational mechanisms that are associated with a regulatory part within the N-terminal part of cystathionine gamma-synthase.
Amir
Rachel
R
Plant Science Laboratory, Migal Galilee Technological Center, PO Box 90000, Rosh Pina 12100, Israel. rachel@migal.org.il
Hacham
Yael
Y
Galili
Gad
G
D001224:Aspartic Acid / Q000378:metabolism; D001667:Binding, Competitive; D002244:Carbon / Q000378:metabolism*; D019757:Carbon-Oxygen Lyases / Q000235:genetics / Q000378:metabolism*; D006714:Homoserine / Q000031:analogs & derivatives* / Q000378:metabolism; D008715:Methionine / Q000378:metabolism*; D063245:Plant Development; D010944:Plants / Q000235:genetics* / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D012323:RNA Processing, Post-Transcriptional
D001224:Aspartic Acid; C011066:O-phosphohomoserine; D006714:Homoserine; D002244:Carbon; D008715:Methionine; C022696:O-succinylhomoserine (thiol)-lyase; D019757:Carbon-Oxygen Lyases; C023160:threonine synthase