SANS study on the effect of lanthanide ions and charged lipids on the morphology of phospholipid mixtures. Small-angle neutron scattering.
The structural phase behavior of phospholipid mixtures consisting of short-chain (dihexanoyl phosphatidylcholine) and long-chain lipids (dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol), with and without lanthanide ions was investigated by small-angle neutron scattering (SANS). SANS profiles were obtained from 10 degrees C to 55 degrees C using lipid concentrations ranging from 0.0025 g/ml to 0.25 g/ml. The results reveal a wealth of distinct morphologies, including lamellae, multi-lamellar vesicles, unilamellar vesicles, and bicellar disks.
Nieh
Mu-Ping
MP
Materials Science and Engineering Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA. muping.nieh@nist.gov
Glinka
Charles J
CJ
Krueger
Susan
S
Prosser
R Scott
RS
Katsaras
John
J
D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D028581:Lanthanoid Series Elements; D008051:Lipid Bilayers; D008823:Micelles; D008958:Models, Molecular; D008962:Models, Theoretical; D008968:Molecular Conformation; D010713:Phosphatidylcholines / Q000737:chemistry*; D010715:Phosphatidylglycerols / Q000737:chemistry; D010742:Phospholipid Ethers / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry*; D013329:Structure-Activity Relationship
C052298:1,2-dihexadecyl-sn-glycero-3-phosphocholine; D028581:Lanthanoid Series Elements; D008051:Lipid Bilayers; D008823:Micelles; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D010742:Phospholipid Ethers; D010743:Phospholipids; C002773:dimyristoylphosphatidylglycerol; D004134:Dimyristoylphosphatidylcholine