title: Long-term endothelial cell loss after phacoemulsification: peribulbar anesthesia versus intracameral lidocaine 1%: prospective randomized clinical trial.
abstract: OBJECTIVE
  To evaluate endothelial cell loss after phacoemulsification with posterior chamber intraocular lens implantation using peribulbar anesthesia or topical anesthesia combined with intracameral unpreserved lidocaine 1%.
  
  
  METHODS
  Department of Ophthalmology, Charité, Humboldt-University of Berlin, Berlin, Germany.
  
  
  METHODS
  Before and 20 months +/- 5.1 (SD) after surgery, specular microscopy was used to evaluate the number and morphology of endothelial cells in 78 eyes having peribulbar anesthesia or topical anesthesia combined with an intracameral injection of 0.15 cc unpreserved lidocaine 1%.
  
  
  RESULTS
  The mean endothelial cell loss was 11.11% in the peribulbar group and 12.55% in the topical/lidocaine group. There was no statistically significant difference in the amount of endothelial cell loss or cell morphology between the 2 groups.
  
  
  CONCLUSIONS
  The long-term postoperative endothelial cell course showed that topical anesthesia combined with an intracameral injection of 0.15 cc unpreserved lidocaine 1% is a safe alternative to peribulbar anesthesia.
authors.affiliation: Department of Ophthalmology, Charité, Faculty of Humboldt University of Berlin, Berlin, Germany. tim.heuermann@charite.de
authors.forename: Tim
authors.initials: T
authors.lastname: Heuermann
authors.forename: Christian
authors.initials: C
authors.lastname: Hartmann
authors.forename: Norbert
authors.initials: N
authors.lastname: Anders
mesh_terms: D000368:Aged; D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000867:Anterior Chamber / Q000187:drug effects; D002452:Cell Count; D002470:Cell Survival; D004728:Endothelium, Corneal / Q000166:cytology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019654:Lens Implantation, Intraocular; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008853:Microscopy; D009883:Ophthalmic Solutions; D009915:Orbit / Q000187:drug effects; D018918:Phacoemulsification; D011310:Preservatives, Pharmaceutical; D011446:Prospective Studies; D012449:Safety
chemical_list: D000779:Anesthetics, Local; D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical; D008012:Lidocaine