title: Changes in fluorescein angiogram early after surgical removal of choroidal neovascularization in age-related macular degeneration.
abstract: BACKGROUND
  Retinal pigment epithelial (RPE) defects inevitably occur in surgical removal of choroidal neovascularization (CNV) in age-related macular degeneration (AMD). RPE can proliferate and cover the denuded area, but the healing process has not been investigated in humans. To understand the RPE wound-healing process, we estimated the changes in fluorescein angiograms early after CNV removal.
  
  
  METHODS
  Ten consecutive patients with exudative AMD underwent CNV removal without gas tamponade. Fluorescein angiography was performed within 4 days of surgery and again 1 or 2 weeks postoperatively. Areas of leakage were measured using a computer-assisted image analyser. The decreasing rate of leakage was calculated as the change in disc areas of leakage per day (DA/day).
  
  
  RESULTS
  The rates of decreasing leakage ranged from 0 to 0.42 DA/day (mean, 0.24 +/- 0.15 DA/day; median, 0.26 DA/day). The rate of decreasing leakage correlated with changes in visual acuity (r = 0.642, P = 0.0456).
  
  
  CONCLUSIONS
  The retinal pigment epithelial wound after surgical removal of choroidal neovascularization may heal at the rate of 0.24 disc areas/day based on the blood retinal barrier function in patients with age-related macular degeneration. A faster rate of decreasing leakage may be associated with better visual prognosis.
authors.affiliation: Department of Ophthalmology, Osaka University Medical School, Suita, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Sawa
authors.forename: Motohiro
authors.initials: M
authors.lastname: Kamei
authors.forename: Masahito
authors.initials: M
authors.lastname: Ohji
authors.forename: Masanobu
authors.initials: M
authors.lastname: Motokura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Saito
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Tano
mesh_terms: D000368:Aged; D020256:Choroidal Neovascularization / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008268:Macular Degeneration / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010857:Pigment Epithelium of Eye / Q000502:physiology; D011446:Prospective Studies; D014945:Wound Healing / Q000502:physiology