Three new triterpene saponins from two species of Carpolobia.
Three new acetylated triterpene saponins 1-3 were isolated from the roots of Carpolobia alba and C. lutea. Their structures were established mainly by 2D NMR techniques as 3-O-beta-D-glucopyranosylpresenegenin-28-O-beta-D-galactopyranosyl-(1-->4)-[beta-D-xylopyranosyl-(1-->3)]-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-(3,4-di-O-acetyl)-beta-D-fucopyranosyl ester, 3-O-beta-D-glucopyranosylpresenegenin-28-O-beta-D-galactopyranosyl-(1-->4)-[alpha-L-arabinopyranosyl-(1-->3)]-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-(3,4-di-O-acetyl)-beta-D-fucopyranosyl ester, and 3-O-beta-D-glucopyranosylpresenegenin-28-O-beta-D-xylopyranosyl-(1-->4)-[beta-D-apiofuranosyl-(1-->3)]-alpha-L-rhamnopyranosyl-(1-->2)-(3,4-di-O-acetyl)-beta-D-fucopyranosyl ester, respectively.
Mitaine-Offer
Anne-Claire
AC
Laboratoire de Pharmacognosie, Unité MIB, J E 2244, Faculté de Pharmacie, Université de Bourgogne, 7, Bd. Jeanne D'Arc, BP 87900, 21079 Dijon Cedex, France.
Miyamoto
Tomofumi
T
Khan
Ikhlas A
IA
Delaude
Clément
C
Lacaille-Dubois
Marie-Aleth
MA
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D002945:Cisplatin / Q000494:pharmacology; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006868:Hydrolysis; D015394:Molecular Structure; D009549:Nigeria; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010946:Plants, Medicinal / Q000737:chemistry*; D029608:Polygalaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
C457159:3-O-beta-D-glucopyranosylpresenegenin-28-O-beta-D-galactopyranosyl-(1-4)-(alpha-L-arabinopyranosyl-(1-3))-beta-D-xylopyranosyl-(1-4)-alpha-L-rhamnopyranosyl-(1-2)-(3,4-di-O-acetyl)-beta-D-fucopyranosyl ester; C457161:3-O-beta-D-glucopyranosylpresenegenin-28-O-beta-D-galactopyranosyl-(1-4)-(beta-D-xylopyranosyl-(1-3))-beta-D-xylopyranosyl-(1-4)-alpha-L-rhamnopyranosyl-(1-2)-(3,4-di-O-acetyl)-beta-D-fucopyranosyl ester; C457160:3-O-beta-D-glucopyranosylpresenegenin-28-O-beta-D-xylopyranosyl-(1-4)-(beta-D-apiofuranosyl-(1-3))-alpha-L-rhamnopyranosyl-(1-2)-(3,4-di-O-acetyl)-beta-D-fucopyranosyl ester; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes; D009828:Oleanolic Acid; D002945:Cisplatin