Intragenic breakpoint within RAD51L1 in a t(6;14)(p21.3;q24) of a pulmonary chondroid hamartoma.
Rearrangements involving chromosome region 14q23-->q24 represent a main cytogenetic subgroup in a variety of benign solid tumors. Recently, in uterine leiomyomas containing the classical t(12;14)(q15;q23-->q24), the primary chromosome 14 target gene was identified as the protein kinase-encoding gene RAD51L1. In this report we show that RAD51L1 is also involved in the frequently occurring t(6;14) (p21;q23-->q24) in pulmonary chondroid hamartomas.
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Center for Human Genetics, University of Bremen, Bremen, Germany.
Schoenmakers
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EF
Rogalla
P
P
Huys
E H
EH
van Rijk
A A
AA
Drieschner
N
N
Bullerdiek
J
J
D019457:Chromosome Breakage / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005091:Exons / Q000235:genetics; D006222:Hamartoma / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008171:Lung Diseases / Q000235:genetics*; D020161:Physical Chromosome Mapping; D051135:Rad51 Recombinase; D014178:Translocation, Genetic / Q000235:genetics*
D004268:DNA-Binding Proteins; C495153:RAD51 protein, human; D051135:Rad51 Recombinase