title: [The Brugada syndrome].
abstract: On the case of a patient who had medical care on account of a febrile disease diagnosed as pleuritis the authors draw attention to a relatively new pathological unit described as the "Brugada syndrome". It is a genetically conditioned anomaly of sodium channels, which, when fully expressed, is manifested by a picture resembling right bundle branch block, elevation of ST segment in leads V1-V3 and the occurrence of malignant ventricular arrhythmias or sudden death without structural heart disease. Neither the reported patient nor his family suffered from arrhythmias. The authors present however a typical electrocardiographic picture ad positive test with ajmaline, a substance which by blocking sodium channels can frequently induce latent and variable changes.
authors.affiliation: II. interní klinika LF UK Plzen a Fakultní nemocnice, Plzen.
authors.forename: A
authors.initials: A
authors.lastname: Mádle
authors.forename: Z
authors.initials: Z
authors.lastname: Kratochvíl
authors.forename: A
authors.initials: A
authors.lastname: Polívková
mesh_terms: D002037:Bundle-Branch Block / Q000175:diagnosis*; D016757:Death, Sudden, Cardiac; D004562:Electrocardiography; D005334:Fever; D006801:Humans; D008297:Male; D008875:Middle Aged; D015222:Sodium Channels / Q000235:genetics* / Q000378:metabolism; D013577:Syndrome
chemical_list: D015222:Sodium Channels