[A study on DNA damage of mouse livers induced by methylmercury].
OBJECTIVE
To study the DNA damage induced by methylmercury (MeHg) in mouse hepatocytes.


METHODS
The single cell gel electrophoresis (SCGE) was used to study the DNA damage of mouse hepatocytes when treated with different doses in vivo and in vitro.


RESULTS
After treated with high, middle and low doses of MeHg for 12 h in vivo (i.p.), the proportion of DNA damage was increased and the ratio of living cells was decreased; and both effects showed significantly dose-effect relationships. Similar effects were found when different MeHg doses were administered to hepatocytes in vitro for 1 h.


CONCLUSIONS
MeHg induces DNA damage in mouse hepatocytes.
Liu
Xiaomei
X
Department of Hygienic Chemistry, School of Public Health, Jinlin University, Changchun 130021, China.
Sun
Zhiwei
Z
Shi
Long
L
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004249:DNA Damage; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008767:Methylmercury Compounds / Q000009:adverse effects*; D051379:Mice
D008767:Methylmercury Compounds