Effect of ischemic preconditioning and mitochondrial KATP channel openers on chronic left ventricular remodeling in the ischemic-reperfused rat heart.
The influence of ischemic preconditioning (IP) and mitochondrial ATP-sensitive potassium (mito-KATP) channel openers on chronic left ventricular (LV) remodeling remains unknown, so the effect of IP and mito-KATP channel openers on the LV pressure-volume curve was assessed in rats subjected to 30 min ischemia followed by a 3-week reperfusion. Infarct size was histologically determined at 3 weeks after reperfusion. The LV pressure-volume curve was significantly shifted left by IP, diazoxide and nicorandil compared with the controls. These effects were blocked by the selective mito-KATP channel blocker 5-hydroxydecanoate. The LV remodeling and the infarct size at 3 weeks after reperfusion correlated well, indicating that the reduction of LV remodeling in the ischemic-reperfused model was strongly influenced by attenuation of the ischemic injury. LV remodeling in the chronic phase is attenuated by IP and mito-KATP channel openers with concomitant reduction of infarct size.
Dairaku
Yuka
Y
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicine, Ube, Japan.
Miura
Toshiro
T
Harada
Nozomu
N
Kimura
Masayasu
M
Okamura
Takayuki
T
Iwamoto
Hiroshi
H
Kametani
Ryosuke
R
Yamada
Michio
M
Ikeda
Yasuhiro
Y
Iwatate
Mitsuo
M
Kawamura
Shuji
S
Matsuzaki
Masunori
M
D000818:Animals; D003981:Diazoxide / Q000494:pharmacology*; D006339:Heart Rate; D015640:Ion Channel Gating / Q000502:physiology*; D019194:Ischemic Preconditioning; D008297:Male; D008565:Membrane Proteins / Q000187:drug effects / Q000502:physiology; D008929:Mitochondria, Heart / Q000502:physiology*; D015425:Myocardial Reperfusion; D020108:Nicorandil / Q000494:pharmacology*; D015221:Potassium Channels; D051381:Rats; D017207:Rats, Sprague-Dawley; D016277:Ventricular Function, Left / Q000502:physiology*
D008565:Membrane Proteins; D015221:Potassium Channels; C117780:mitochondrial K(ATP) channel; D020108:Nicorandil; D003981:Diazoxide