title: Oncocytoma-like angiomyolipoma. A clinicopathologic and immunohistochemical study of 2 cases.
abstract: We report the clinical, pathologic, and immunohistochemical features of an unusual tumor of the kidney composed of densely eosinophilic, polygonal epithelioid cells. The patients were a 56-year-old woman and a 35-year-old man. The renal tumors were discovered during follow-up for breast carcinoma and evaluation for abdominal pain, respectively. The tumors closely resembled oncocytoma in routine sections, but were negative for epithelial markers and positive for HMB-45, a pattern of reactions characteristic of angiomyolipoma. In the woman, a single additional microscopic angiomyolipoma was present in the renal parenchyma at a distance from the main tumor. Both patients are alive without recurrence 7 and 10 years after surgery, respectively. Based on clinical, morphologic, and immunophenotypic features, we conclude that these tumors are oncocytoma-like angiomyolipomas.
authors.affiliation: Dipartimento di Patologia-Sezione Anatomia Patologica, Universita' di Verona, Verona, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Martignoni
authors.forename: Maurizio
authors.initials: M
authors.lastname: Pea
authors.forename: Franco
authors.initials: F
authors.lastname: Bonetti
authors.forename: Matteo
authors.initials: M
authors.lastname: Brunelli
authors.forename: John N
authors.initials: JN
authors.lastname: Eble
mesh_terms: D018249:Adenoma, Oxyphilic / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000328:Adult; D018207:Angiomyolipoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000951:Antigens, Neoplasm; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D007680:Kidney Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008297:Male; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins