[Role of family in development of neurophysiological manifestations in children with migraine].
Migraine is a familial disorder. The aim of this study was to compare the relationship between specific neurophysiologic pathogenetic mechanisms of migraine such as abnormal information processing and enhanced cortical excitability on the one hand, and parent-child-interactions and personality traits such as neuroticism and extraversion on the other hand in migraine and healthy families. The correlation and factor analyses demonstrated that the stronger the control over a child and the more intensive the suppression of a child's independence by a parent during a stressful situation in migraine families, the more pronounced the loss of habituation of the contingent negative variation (CNV), and the greater the neuroticism in a migraine child. The CNV amplitude was independent of psychosocial conditions in the family but represented similarities in information processing between parents and their children suffering from migraine. This could be possibly explained by genetic influences on information processing in migraine. In healthy families only the relationship between parameters of parent-child-interaction could be observed. This investigation demonstrates that the neurophysiological disposition to a migraine attack as well as personality traits in migraine could be influenced by psychosocial factors such as parent-child interactions and that different parameters of information processing in headache patients are related to either non-genetic familial conditions (habituation) or functional genetic factors (amplitude).
Siniatchkin
Michael
M
Klinik für Kinder- und Jugendpsy-chiatrie und Psychotherapie, Georg-August-Universität zu Göttingen, von-Siebold-Str. 5, 37075 Göttingen. msiniat@gwdg.de
Gerber
Wolf-Dieter
WD
D001143:Arousal / Q000502:physiology*; D002540:Cerebral Cortex / Q000503:physiopathology; D002648:Child; D003265:Contingent Negative Variation / Q000235:genetics; D005260:Female; D006801:Humans; D007389:Internal-External Control; D008297:Male; D008881:Migraine Disorders / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D009460:Neurologic Examination; D010287:Parent-Child Relations; D016487:Parenting / Q000523:psychology; D010552:Personality Assessment; D012307:Risk Factors