title: JAHK: a low frequency antigen associated with the rG complex of the Rh blood group system.
abstract: We have investigated a 'new' low frequency antigen JAHK, which is a marker for the rare Rh gene complex rG. The rG haplotype does not produce any D, c or E antigens, but does produce a strong G antigen. The rG haplotype [d(C)(e)G] is associated with weak C and weak e antigens. Three unrelated rG/dce individuals and one rG/rG propositus were JAHK+. In addition, three propositi whose red cells had a typical expression of C and/or e antigen, which could not be shown to be rG because of a normal D antigen produced by the haplotype in trans, were also JAHK+. Families of three of the propositi demonstrate the inheritance of JAHK as a Mendelian dominant character. It is likely that the JAHK antigen results from conformational changes in an RhCcEe protein that has the amino acid characteristic of c antigen at position 16 and the amino acid residues characteristic of C antigen at positions 60, 68, and 103. JAHK has been assigned the number RH53.
authors.affiliation: Bristol Institute for Transfusion Sciences, Bristol, UK.
authors.forename: C
authors.initials: C
authors.lastname: Green
authors.forename: G
authors.initials: G
authors.lastname: Coghlan
authors.forename: M
authors.initials: M
authors.lastname: Bizot
authors.forename: D
authors.initials: D
authors.lastname: Kasulke
authors.forename: M
authors.initials: M
authors.lastname: Bombail-Girard
authors.forename: M
authors.initials: M
authors.lastname: Wallace
authors.forename: C
authors.initials: C
authors.lastname: Lomas-Francis
authors.forename: G
authors.initials: G
authors.lastname: Daniels
mesh_terms: D001788:Blood Grouping and Crossmatching; D004912:Erythrocytes / Q000276:immunology*; D005060:Europe; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007519:Isoantigens / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D008297:Male; D010375:Pedigree; D012204:Rh-Hr Blood-Group System / Q000235:genetics / Q000276:immunology*
chemical_list: D007519:Isoantigens; D012204:Rh-Hr Blood-Group System