Interaction between methotrexate and ciprofloxacin.
High-dose methotrexate is used in malignant hemopathies and solid tumors in children. Methotrexate serum concentrations must be monitored because of the possible toxicity of drug elimination delay. Several drugs (e.g., penicillin, probenecid) can alter the elimination of methotrexate. The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.
Dalle
Jean-Hugues
JH
Unite d'Onco-Hematologie Pediatrique, Hopital Jeanne de Flandre, Lille, France. jhdalle@wanadoo.fr
Auvrignon
Anne
A
Vassal
Gilles
G
Leverger
Guy
G
D000293:Adolescent; D000890:Anti-Infective Agents / Q000009:adverse effects*; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000493:pharmacokinetics; D001859:Bone Neoplasms / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D002939:Ciprofloxacin / Q000009:adverse effects* / Q000493:pharmacokinetics; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D009447:Neuroblastoma / Q000188:drug therapy; D012516:Osteosarcoma / Q000188:drug therapy
D000890:Anti-Infective Agents; D000964:Antimetabolites, Antineoplastic; D002939:Ciprofloxacin; D008727:Methotrexate