Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein.
Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Src SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised.
Deprez
Pierre
P
Aventis Pharma, Paris Research Center, Medicinal Chemistry, 102 route de Noisy, 93235 Cedex, Romainville, France. pierre.deprez@aventis.com
Mandine
Eliane
E
Gofflo
Dominique
D
Meunier
Stéphane
S
Lesuisse
Dominique
D
D001665:Binding Sites; D008024:Ligands; D019000:Phosphotyrosine / Q000378:metabolism*; D018909:src Homology Domains
D008024:Ligands; D019000:Phosphotyrosine