title: Neuroanatomic characterization of schizoaffective disorder using MRI: a pilot study.
abstract: For over 50 years, there has been uncertainty in the conceptual understanding and neuropathogenesis of the diagnosis of schizoaffective disorder (SCA). In order to better characterize SCA, we performed a quantitative assessment of MRI neuroanatomical structures in patients with SCA (n = 12), compared to patients with bipolar disorder (BPD) (n = 12) and healthy volunteers (HV) (n = 12). Patients diagnosed with SCA exhibited regional abnormalities on the striatum that resemble those seen in BPD. This study suggests that SCA has some neuroanatomical characteristics similar to BPD.
authors.affiliation: Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0559, USA. getzg@email.uc.edu
authors.forename: Glen E
authors.initials: GE
authors.lastname: Getz
authors.forename: Melissa P
authors.initials: MP
authors.lastname: DelBello
authors.forename: David E
authors.initials: DE
authors.lastname: Fleck
authors.forename: Molly E
authors.initials: ME
authors.lastname: Zimmerman
authors.forename: Michael L
authors.initials: ML
authors.lastname: Schwiers
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Strakowski
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000473:pathology; D001921:Brain / Q000473:pathology; D003342:Corpus Striatum / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000473:pathology