Fluorescent tetracycline labeling as an aid to debridement of necrotic bone in the treatment of chronic osteomyelitis.
The authors have found that several months of preoperative tetracycline administration will label living bone so that it fluoresces under a blacklight during surgery. This allows intraoperative differentiation of viable bone from necrotic sequestra, which require removal in the treatment of chronic bone infection.
Dahners
Laurence E
LE
Department of Orthopaedics, University of North Carolina, Campus Box 7055, Chapel Hill, NC 27599, USA.
Bos
Gary D
GD
D002908:Chronic Disease; D003646:Debridement / Q000379:methods; D005453:Fluorescence; D006801:Humans; D007202:Indicators and Reagents; D010019:Osteomyelitis / Q000150:complications / Q000601:surgery*; D010020:Osteonecrosis / Q000209:etiology / Q000601:surgery*; D011300:Preoperative Care / Q000379:methods; D012680:Sensitivity and Specificity; D013752:Tetracycline / Q000008:administration & dosage*
D007202:Indicators and Reagents; D013752:Tetracycline