A prospective study of motor recovery following multiple subpial transections.
A prospective study of motor recovery was undertaken in a patient scheduled to undergo multiple subpial transections (MST) of right sensorimotor cortex. Pre-transection, functional MRI (fMRI) and cortical stimulation mapping confirmed left hand motor control within right primary motor cortex. Immediately post-transection, behavioral testing demonstrated preserved strength bilaterally but decreased dexterity in the left hand. Seven weeks post-transection, dexterity returned to normal and left hand finger tapping corresponded with multiple bilateral foci of fMRI activation. At 16 weeks, fMRI activation returned to pre-transection levels. These data indicate that cortical injury due to MST resulted in the temporary recruitment of distant cortical sites which presumably subserved normal motor function during recovery.
Moo
Lauren R
LR
Department of Neurology, Meyer 100, 600 North Wolfe Street, Johns Hopkins University, Baltimore, MD 21287, USA.
Slotnick
Scott D
SD
Krauss
Gregory
G
Hart
John
J
D000328:Adult; D004558:Electric Stimulation / Q000009:adverse effects*; D004567:Electrodes, Implanted / Q000009:adverse effects; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000502:physiology* / Q000601:surgery; D009048:Motor Skills / Q000502:physiology*; D011446:Prospective Studies; D020127:Recovery of Function / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology / Q000601:surgery