title: Factor VII deficiency in pregnancy treated with recombinant factor VIIa.
abstract: BACKGROUND
  Factor VII deficiency is an autosomal recessive bleeding disorder with an incidence of one in 500,000. Few cases have been reported in pregnancy, and only two patients were treated with recombinant factor VIIa. In the past, fresh frozen plasma or factor VII concentrate has been the conventional treatment for this disorder.
  
  
  METHODS
  We report a case of factor VII deficiency diagnosed during pregnancy with a factor VII level of 1%. After prophylactic treatment with recombinant factor VIIa, the patient did not manifest any signs or symptoms of excessive bleeding during labor or postpartum.
  
  
  CONCLUSIONS
  Given the inherent risks of transmission of human immunodeficiency virus and hepatitis with blood products, recombinant factor VIIa treatment is an alternative that is safe and effective during labor, delivery, and the puerperium.
authors.affiliation: Department of Obstetrics and Gynecology, Olive View-UCLA Medical Center, Sylmar, California, USA. nilooesk@yahoo.com
authors.forename: Niloofar
authors.initials: N
authors.lastname: Eskandari
authors.forename: Nancy
authors.initials: N
authors.lastname: Feldman
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Greenspoon
mesh_terms: D036861:Delivery, Obstetric; D005168:Factor VII Deficiency / Q000175:diagnosis / Q000188:drug therapy*; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D015942:Factor VIIa