title: [Study of the function of leukocyte adhesion molecules in chronic respiratory diseases].
abstract: OBJECTIVE
  To study the function of leukocyte adhesion molecules in the pathogenesis of Chronic Obstructive Pulmonary Diseases (COPD) and cor pulmonale, and to evaluate the effect of anti-leukocyte-adhesion therapy for cor pulmonale.
  
  
  METHODS
  The positive expression rates of CD(11a), CD(11b), CD(18), CD(54) in peripheral blood were quantitatively analyzed by flow cytometry using monoclonal antibodies in 42 cases of COPD (stable stage), 41 cases of cor pulmonale (stable stage), 24 healthy controls as well as 20 cases of cor pulmonale who had taken huobahua.
  
  
  RESULTS
  The expression rates of CD(11a), CD(11b), CD(18), CD(54) in monocytes and CD(11a) in lymphocytes from the COPD group were much higher than those in the control group (P < 0.05). CD(11a), CD(11b), CD(18), CD(54) in neutrophils and CD(11a), CD(18), CD(54) in monocytes, and CD(18) in lymphocytes in the cor pulmonale group were significantly stronger than those in the control group (P < 0.05); whereas the positive expression of CDs was greatly reduced in the cor pulmonale patients who had taken huobahua (P < 0.05). No differences were found in other groups.
  
  
  CONCLUSIONS
  Upregulation of CD(11a)/CD(18), CD(11b)/CD(18), CD(54) in monocytes, CD(11a)/CD(18), CD(11b)/CD(18), CD(54) in neutrophils and CD(11a)/CD(18), CD(54) in monocytes in cor pulmonale may promote adhesion of leukocytes with endothelial cells, which may play an important role in the pathogenic process. Huobahua may prevent the development of cor pulmonale by down regulating the expression of CDs.
authors.affiliation: Department of Respiratory Medicine, The Fourth Hospital of Sichuan Province, Chengdu 610016, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Derong
authors.initials: D
authors.lastname: Li
authors.forename: Haiying
authors.initials: H
authors.lastname: Lu
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Wan
authors.forename: Xiang
authors.initials: X
authors.lastname: Peng
authors.forename: Song
authors.initials: S
authors.lastname: Lei
authors.forename: Dong
authors.initials: D
authors.lastname: Zhou
mesh_terms: D000368:Aged; D018821:CD18 Antigens / Q000096:biosynthesis / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000096:biosynthesis / Q000276:immunology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000096:biosynthesis / Q000276:immunology*; D016177:Macrophage-1 Antigen / Q000096:biosynthesis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy / Q000276:immunology*; D011660:Pulmonary Heart Disease / Q000188:drug therapy / Q000276:immunology
chemical_list: D018821:CD18 Antigens; D015815:Cell Adhesion Molecules; D007166:Immunosuppressive Agents; D016169:Lymphocyte Function-Associated Antigen-1; D016177:Macrophage-1 Antigen; D018799:Intercellular Adhesion Molecule-1