Combined analysis of the ORCHID and OCAY studies: does eradication of Helicobacter pylori lead to sustained improvement in functional dyspepsia symptoms?
Currently, one of the most important unresolved questions concerning Helicobacter pylori is whether eradication of the organism leads to a sustained improvement in symptoms in patients diagnosed with functional (non-ulcer) dyspepsia. Recently, two very similar studies, the ORCHID and OCAY studies, have been completed and the combined results of these two multicentre, multinational, randomised, double blind, controlled clinical trials are reviewed.
Veldhuyzen van Zanten
S J O
SJ
Division of Gastroenterology, Dalhousie University, Queen Elizabeth II Health Sciences Centre, Victoria General Site, Room 928 Centennial Building, 5790 University Avenue, Halifax, Nova Scotia, Canada B3H 2YG, Canada. zanten@is.dal.ca
Talley
N J
NJ
Blum
A L
AL
Bolling-Sternevald
E
E
Sundin
M
M
Junghard
O
O
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D004311:Double-Blind Method; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004415:Dyspepsia / Q000188:drug therapy / Q000382:microbiology*; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009853:Omeprazole / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D009853:Omeprazole