Plasticity of lymphoid compartments during HIV infection and treatments: hopes and limits.
Immune reconstitution during antiretroviral therapy has recently been shown to depend upon multiple factors at work in T-cell homeostasis, amongst which the reduction of thymus dysfunction and of immune hyperactivation is instrumental. The restoration of host defenses against opportunistic pathogens is, however, balanced by the poor immunity restored against HIV thus giving a satisfying link between antigen stimulation and the reconstitution of immune responses to pathogens.
Combadière
Béhazine
B
Laboratoire d'Immunologie Cellulaire et Tissulaire, Unité INSERM 543, Hôpital Pitié-Salpétrière, 83, boulevard de l'Hôpital, 75013 Paris, France.
Carcelain
Guislaine
G
Debré
Patrice
P
Autran
Brigitte
B
D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000821:virology; D015658:HIV Infections / Q000276:immunology* / Q000628:therapy* / Q000821:virology; D006706:Homeostasis; D006801:Humans; D008213:Lymphocyte Activation; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000473:pathology / Q000821:virology*; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology
D019380:Anti-HIV Agents