Human papillomavirus antigens and T-cell recognition.
This review will summarize what is known about natural T-cell responses to human papillomavirus infections, including potential mechanisms for their dysregulation which may lead to the development of disease. We will also describe new strategies to enhance human papillomavirus specific T-cell responses following vaccination that are currently in development and recent reports on human vaccine trials with particular regard to the generation of appropriate T-cell responses.
Luxton
J
J
Department of Immunobiology, Guy's, King's and St Thomas' School of Medicine, London, UK.
Shepherd
P
P
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D005260:Female; D006801:Humans; D051379:Mice; D027383:Papillomaviridae / Q000276:immunology*; D030361:Papillomavirus Infections / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D013601:T-Lymphocytes / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D014765:Viral Vaccines / Q000276:immunology
D000956:Antigens, Viral; D014765:Viral Vaccines