title: Stevens-Johnson syndrome presumably induced by bromhexine. A case report.
abstract: The Stevens-Johnson syndrome is a serious form of erythema multiforme, an acute inflammatory pathology with an autoimmune pathogenesis. Its etiology is unknown, although it is thought to have multifactorial causes; nonetheless, many drugs are thought to induce such an immune response. The clinical symptomatology is mainly muco-cutaneous, with a remarkable oral involvement. The authors describe here a case of Stevens-Johnson syndrome involving the ocular, oral, and genital areas, presumably induced by the bromhexine administered to the patient for a viral syndrome.
authors.affiliation: Dipartimento di Odontoiatria e Stomatologia, Presidio Ospedaliero Ascalesi, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cafasso
authors.forename: F
authors.initials: F
authors.lastname: Rao
authors.forename: L
authors.initials: L
authors.lastname: Mucciarone
authors.forename: S
authors.initials: S
authors.lastname: Ambrosino Di Miccio
mesh_terms: D000328:Adult; D000871:Anthelmintics / Q000627:therapeutic use; D001964:Bromhexine / Q000009:adverse effects*; D005100:Expectorants / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology; D009930:Organic Chemicals; D010413:Penis / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000871:Anthelmintics; D005100:Expectorants; D009930:Organic Chemicals; C407664:deltacortene; D001964:Bromhexine