The activity of leukocyte NADPH oxidase: regulation by p47PHOX cysteine and serine residues.
The leukocyte NADPH oxidase is regulated chiefly by phosphorylation of the serines of p47(PHOX), one of its cytosolic subunits. Its activity is also regulated, however, by the four cysteines of the same subunit, as indicated by the replacement of those cysteines by alanines.
Babior
Bernard M
BM
The Scripps Research Institute, La Jolla, CA 92037, USA.
D000409:Alanine / Q000378:metabolism; D002474:Cell-Free System; D003545:Cysteine / Q000378:metabolism*; D003600:Cytosol / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D008214:Lymphocytes / Q000378:metabolism; D009154:Mutation; D019255:NADPH Oxidases / Q000378:metabolism*; D010084:Oxidation-Reduction; D010750:Phosphoproteins / Q000737:chemistry* / Q000378:metabolism*; D010766:Phosphorylation; D012694:Serine / Q000378:metabolism*
D010750:Phosphoproteins; D012694:Serine; D019255:NADPH Oxidases; C060505:neutrophil cytosolic factor 1; D003545:Cysteine; D000409:Alanine