title: DFNB31, a recessive form of sensorineural hearing loss, maps to chromosome 9q32-34.
abstract: We report the identification of a novel locus responsible for an autosomal recessive form of hearing loss (DFNB) segregating in a Palestinian consanguineous family from Jordan. The affected individuals suffer from profound prelingual sensorineural hearing impairment. A genetic linkage with polymorphic markers surrounding D9S1776 was detected, thereby identifying a novel deafness locus, DFNB31. This locus could be assigned to a 9q32-34 region of 15 cM between markers D9S289 and D9S1881. The whirler (wi) mouse mutant, characterised by deafness and circling behaviour, maps to the corresponding region on the murine chromosome 4, thus suggesting that DFNB31 and whirler may result from orthologous gene defects.
authors.affiliation: Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur, 75724 Paris cedex 15, France.
authors.forename: Mirna
authors.initials: M
authors.lastname: Mustapha
authors.forename: Eliane
authors.initials: E
authors.lastname: Chouery
authors.forename: Sébastien
authors.initials: S
authors.lastname: Chardenoux
authors.forename: Mohamed
authors.initials: M
authors.lastname: Naboulsi
authors.forename: Joël
authors.initials: J
authors.lastname: Paronnaud
authors.forename: Arnaud
authors.initials: A
authors.lastname: Lemainque
authors.forename: André
authors.initials: A
authors.lastname: Mégarbané
authors.forename: Jacques
authors.initials: J
authors.lastname: Loiselet
authors.forename: Dominique
authors.initials: D
authors.lastname: Weil
authors.forename: Mark
authors.initials: M
authors.lastname: Lathrop
authors.forename: Christine
authors.initials: C
authors.lastname: Petit
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D003241:Consanguinity; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D005838:Genotype; D006239:Haplotypes; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D009154:Mutation; D010375:Pedigree; D011110:Polymorphism, Genetic