title: Impact of chest pain on cost of migraine treatment with almotriptan and sumatriptan.
abstract: Chest-related symptoms occur with all triptans; up to 41% of patients with migraine who receive sumatriptan experience chest symptoms, and 10% of patients discontinue treatment. Thus, the cost of chest pain-related care was estimated in migraineurs receiving almotriptan 12.5 mg versus sumatriptan 50 mg. A population-based, retrospective cohort study used data to quantify the incidence and costs of chest pain-related diagnoses and procedures. An economic model was constructed to estimate annual cost savings per 1000 patients receiving almotriptan versus sumatriptan based on the reported rates of chest pain. Annual direct medical cost avoided was calculated for a hypothetical health plan covering 1 million lives. Among a cohort of 1390 patients, the incidence of chest pain-related diagnoses increased significantly by 43.6% with sumatriptan (P=.003). Aggregate costs for chest pain-related diagnoses and procedures increased from $22,713 to $30,234. Payments for inpatient hospital services, costs for primary care visits, and costs for outpatient hospital visits increased by over 100%, 53.1%, and 14.4%, respectively. The model predicted $11,215 in direct medical cost savings annually per 1000 patients treated with almotriptan versus sumatriptan. Annual direct medical costs avoided totaled $194,358, and when applied to recent estimates of 86 million lives currently covered by almotriptan treatment, translates into an annual cost savings of just under $17 million for chest pain and associated care. Thus, using almotriptan in place of sumatriptan will likely reduce the cost of chest pain-related care.
authors.affiliation: Global Medical Affairs, Pharmacia Corporation, 100 Route 206 North, Peapack, NJ 07110, USA.
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Wang
authors.forename: Charles E
authors.initials: CE
authors.lastname: Barr
authors.forename: Scott D
authors.initials: SD
authors.lastname: Goldfarb
mesh_terms: D000293:Adolescent; D000328:Adult; D002637:Chest Pain / Q000139:chemically induced* / Q000191:economics / Q000453:epidemiology; D015331:Cohort Studies; D017046:Cost Savings; D003362:Cost-Benefit Analysis; D016527:Drug Costs; D004562:Electrocardiography; D005260:Female; D017048:Health Care Costs / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy* / Q000191:economics*; D012189:Retrospective Studies; D017366:Serotonin Receptor Agonists / Q000009:adverse effects* / Q000191:economics / Q000627:therapeutic use; D018170:Sumatriptan / Q000009:adverse effects* / Q000191:economics / Q000627:therapeutic use; D016896:Treatment Outcome; D014363:Tryptamines / Q000009:adverse effects* / Q000191:economics / Q000627:therapeutic use
chemical_list: D017366:Serotonin Receptor Agonists; D014363:Tryptamines; C409045:almotriptan; D018170:Sumatriptan