title: Hodgkin's disease presenting as cholestatic hepatitis with prominent ductal injury.
abstract: In advanced stages of Hodgkin's disease, liver involvement is common. However, Hodgkin's disease mimicking cholestatic hepatitis at presentation is rare. We describe a patient with Hodgkin's disease who was initially considered to have acute cholestatic hepatitis. Liver biopsy demonstrated prominent bile duct injury associated with a florid inflammatory reaction. These changes may represent an early stage of ductal injury, subsequently leading to vanishing bile duct syndrome, a recently documented mechanism of cholestasis in Hodgkin's disease.
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Indiana School of Medicine, Indianapolis, Indiana, USA. sliangpu@iupui.edu
authors.forename: Suthat
authors.initials: S
authors.lastname: Liangpunsakul
authors.forename: Paul
authors.initials: P
authors.lastname: Kwo
authors.forename: George K
authors.initials: GK
authors.lastname: Koukoulis
mesh_terms: D000368:Aged; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D002779:Cholestasis / Q000209:etiology* / Q000473:pathology; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008297:Male