title: Imidazole-based ligands of the Src SH2 protein.
abstract: Starting from known Src SH2 inhibitors incorporating five-membered heterocycles or benzamide scaffolds, we prepared tetrasubstituted imidazole compounds able to interact with the pY, pY+1 and pY+3 binding sites of the Src SH2 protein. The synthesis and biological data are presented.
authors.affiliation: Aventis Pharma, Paris Research Center, Medicinal Chemistry, 102 route de Noisy, 93235 Cedex, Romainville, France. pierre.deprez@aventis.com
authors.forename: Pierre
authors.initials: P
authors.lastname: Deprez
authors.forename: Eliane
authors.initials: E
authors.lastname: Mandine
authors.forename: Annie
authors.initials: A
authors.lastname: Vermond
authors.forename: Dominique
authors.initials: D
authors.lastname: Lesuisse
mesh_terms: D007093:Imidazoles / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D018909:src Homology Domains
chemical_list: D007093:Imidazoles; D008024:Ligands