title: Gelastic seizure with tectal tumor, lobar holoprosencephaly, and subependymal nodules: clinical report.
abstract: Gelastic seizures are characterized by inappropriate, stereotyped laughter and are often first recognized when other epileptic manifestations occur. They are frequently associated with hypothalamic hamartomas. Central nervous system developmental abnormalities are rarely reported with gelastic seizures. There is only one case report of gelastic seizure caused by holoprosencephaly. We report a 2-year-old girl with multiple brain structural abnormalities including tectal tumor (possibly hamartoma), multiple subependymal nodules, and holoprosencephaly. She developed seizures during the newborn period and presented with gelastic seizure and simple partial seizure at 3 months of age.
authors.affiliation: Division of Pediatric Neurology, State University of New York, Health Science Center at Brooklyn, USA. cigdem.akman@Tch.harvard.edu
authors.forename: Cigdem Inan
authors.initials: CI
authors.lastname: Akman
authors.forename: Romaine
authors.initials: R
authors.lastname: Schubert
authors.forename: Maria
authors.initials: M
authors.lastname: Duran
authors.forename: John
authors.initials: J
authors.lastname: Loh
mesh_terms: D002675:Child, Preschool; D004805:Ependyma / Q000002:abnormalities* / Q000473:pathology; D004828:Epilepsies, Partial / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006222:Hamartoma / Q000175:diagnosis*; D016142:Holoprosencephaly / Q000175:diagnosis*; D006801:Humans; D007027:Hypothalamic Diseases / Q000175:diagnosis*; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging