title: [Two fatal cases of methotrexate-induced interstitial pneumonitis].
abstract: We report two cases of methotrexate-induced pneumonitis. Both patients died despite steroid pulse therapy. Postmortem lung tissue revealed diffuse alveolar damage, and focal lung fibrosis. Physicians should be aware of the possibility of MTX-induced interstitial pneumonitis in diagnosing RA patients with MTX when diffuse pulmonary infiltration is present.
authors.affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Saitama, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Matsushima
authors.forename: Noboru
authors.initials: N
authors.lastname: Takayanagi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kawata
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Motegi
authors.forename: Mikio
authors.initials: M
authors.lastname: Ubukata
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sugita
authors.forename: Minoru
authors.initials: M
authors.lastname: Kanazawa
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kawabata
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D017809:Fatal Outcome; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate