[The role of taurine as hydroxyl radical inhibitor and its effect on lipid peroxidation in selenite cataract].
OBJECTIVE
To study the role of taurine as hydroxyl radical and superoxide anion radical inhibitor in vitro and evaluate the effect of intraperitoneal injection of taurine on peroxidation in rat selenite cateractous lenses.


METHODS
Electron spin resonance (ESR) was used to detect hydroxyl radical and superoxide anion radical. The concentrations of malondialdehyde (MDA) in normal lenses, selenite-injected lenses and taurine-treated lenses were measured on the 2 nd, 5 th, 9 th and 14 th days after the first injection of selenite.


RESULTS
Taurine was an inhibitor of hydroxyl radical and superoxide anion radical. Its effect was very obvious. The concentration of MDA in selenite-injected lenses increased significantly after injection of selenite and became higher with the development of cataract. The concentration of MDA in taurine-treated lenses was lower than that in selenite-injected lenses.


CONCLUSIONS
Taurine is an inhibitor of hydroxyl radical and superoxide radical. It can prevent lipid peroxidation in selenite cataractous lenses.
Zhang
Wei
W
Beijing Institute of Ophthalmology, Beijing 100730, China. WZHANG2@unl.edu
Chen
Cuizhen
C
Dong
Bing
B
Lu
Daohui
D
Chen
Dewen
D
D000818:Animals; D002386:Cataract / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite; D013481:Superoxides / Q000378:metabolism; D013654:Taurine / Q000494:pharmacology*
D016166:Free Radical Scavengers; D013481:Superoxides; D013654:Taurine; D017665:Hydroxyl Radical; D008315:Malondialdehyde; D018038:Sodium Selenite