title: A nitric oxide-releasing polydiazeniumdiolate derived from acetonitrile.
abstract: Acetonitrile, frequently used as a solvent in reactions of nitric oxide (NO) with amines and other nucleophiles to introduce the [N(O)NO](-) (diazeniumdiolate) functional group, has itself been shown to react with NO in the presence of strong base to yield methane trisdiazeniumdiolate (1), presumably via an intermediate trisdiazeniumdiolated imidate. Aqueous hydrolysis of 1 does not follow simple first-order kinetics and produces mixtures of NO and nitrous oxide in ratios that vary with solution pH. [reaction: see text]
authors.affiliation: Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
authors.forename: Ernst V
authors.initials: EV
authors.lastname: Arnold
authors.forename: Michael L
authors.initials: ML
authors.lastname: Citro
authors.forename: Larry K
authors.initials: LK
authors.lastname: Keefer
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Hrabie
mesh_terms: D000097:Acetonitriles / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry; D007202:Indicators and Reagents; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D009569:Nitric Oxide / Q000737:chemistry*; D012015:Reference Standards; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000097:Acetonitriles; D001391:Azo Compounds; D007202:Indicators and Reagents; D012997:Solvents; D009569:Nitric Oxide