title: Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients.
abstract: Levels of the potent pro-inflammatory prostaglandin E(2) (PGE(2)) are elevated in postmortem spinal cords from patients with ALS, and inhibition of a key PGE(2)-synthesizing enzyme, cylcooxygenase-2, is neuroprotective in an in vitro model of ALS. The authors report that 82% of the patients with ALS studied had 2 to 10 times higher PGE(2) levels in CSF compared with normal control subjects. That affected areas of the CNS are inflamed in ALS supports this. CSF PGE(2) measurement may be useful in monitoring treatment for ALS.
authors.affiliation: Universitätsklinik für Neurologie, Allgemeines Krankenhaus der Stadt Wien, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Almer
authors.forename: P
authors.initials: P
authors.lastname: Teismann
authors.forename: Z
authors.initials: Z
authors.lastname: Stevic
authors.forename: J
authors.initials: J
authors.lastname: Halaschek-Wiener
authors.forename: L
authors.initials: L
authors.lastname: Deecke
authors.forename: V
authors.initials: V
authors.lastname: Kostic
authors.forename: S
authors.initials: S
authors.lastname: Przedborski
mesh_terms: D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid*; D015415:Biomarkers; D015232:Dinoprostone / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007118:Immunoassay; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D015232:Dinoprostone