title: Base-pairing systems related to TNA: alpha-threofuranosyl oligonucleotides containing phosphoramidate linkages.
abstract: (3'NH)- and (2'NH)-TNA, two isomeric phosphoramidate analogues of TNA (alpha-threofuranosyl-(3'-->2') oligonucleotides), are shown to be efficient Watson-Crick base-pairing systems and to undergo intersystem cross-pairing with TNA, RNA, and DNA. [reaction: see text]
authors.affiliation: The Skaggs Institute for Chemical Biology at the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Wu
authors.forename: Sreenivasulu
authors.initials: S
authors.lastname: Guntha
authors.forename: Mathias
authors.initials: M
authors.lastname: Ferencic
authors.forename: Ramanarayanan
authors.initials: R
authors.lastname: Krishnamurthy
authors.forename: Albert
authors.initials: A
authors.lastname: Eschenmoser
mesh_terms: D000577:Amides / Q000737:chemistry; D020029:Base Pairing; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D007202:Indicators and Reagents; D009841:Oligonucleotides / Q000737:chemistry; D010756:Phosphoric Acids / Q000737:chemistry; D012313:RNA / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000577:Amides; D005663:Furans; D007202:Indicators and Reagents; D009841:Oligonucleotides; D010756:Phosphoric Acids; D012313:RNA; D004247:DNA; C011067:phosphoramidic acid