Anatomic and functional characteristics of the rat ileal pouch.
BACKGROUND
The definitive operation for chronic ulcerative colitis (UC) and familial adenomatous polyposis is total proctocolectomy with ileal pouch-anal anastomosis (IPAA). Mild inflammation (pouchitis) is omnipresent in pouches and becomes severe in 50% of UC patients with IPAA. The etiology of pouchitis is likely due to combined genetic, microbial, and immunologic factors. Epithelial cell exposure to surgical trauma and/or to changes in intestinal bacterial composition may account for the inflammatory infiltrate. Progress in understanding pouchitis is restricted by the lack of suitable animal models.


METHODS
An ileal pouch-rectal anastomosis [IPRA] in rats was developed to reproduce a model of human IPAA and clinical, gross and histologic criteria were determined.


RESULTS
Many shared features with human ileal pouch were observed.


CONCLUSIONS
IPRA is an important in vivo model to study mechanisms of repair, defense and immunity that may contribute to pouchitis.
Chen
Chiung-Nien
CN
Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
McVay
Laila D
LD
Batlivala
Zubin S
ZS
Hendren
Samantha K
SK
Swain
Gary P
GP
Salzman
Nita
N
Williams
Noel N
NN
Rombeau
John L
JL
D000714:Anastomosis, Surgical; D000818:Animals; D004195:Disease Models, Animal; D007082:Ileum / Q000473:pathology* / Q000601:surgery; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008643:Mesentery; D009929:Organ Size; D010581:Peyer's Patches / Q000473:pathology; D019449:Pouchitis / Q000209:etiology / Q000473:pathology*; D016737:Proctocolectomy, Restorative; D051381:Rats; D017207:Rats, Sprague-Dawley; D012007:Rectum / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate; D013997:Time Factors