title: [The change of alveolar fluid clearance in acute lung injury rat].
abstract: OBJECTIVE
  To establish the animal model of lung injury caused by hydrochloric acid in rats, measure the alveolar fluid clearance (AFC) in different acidic condition.
  
  
  METHODS
  32 rats were randomly divided into 4 groups which were control group (pH = 7.4) and HCl groups (pH = 7.0, 4.5, 2.5). The animals were anesthetized and ventilated for 1 hour. Blood gas analysis was performed, then the permeability of lung epithelial barrier and AFC were measured.
  
  
  RESULTS
  The permeability of lung epithelial barrier, PaO(2) and AFC of pH 7.0 group were similar to control group (P > 0.05), but declined in pH 4.5 and 2.5 groups (P < 0.05).
  
  
  CONCLUSIONS
  The alveolar epithelium and the alveolar epithelial barrier are resistant to the injurious effects of acid, but high concentration acid can induce damage.
authors.affiliation: Department of Pulmonary, Shanghai Chest Hospital, Shanghai 200030, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Chen
authors.forename: Chunxue
authors.initials: C
authors.lastname: Bai
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Fang
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D004195:Disease Models, Animal; D006863:Hydrogen-Ion Concentration; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000378:metabolism*