Synthesis, characterization and antiamoebic activity of benzimidazole derivatives and their vanadium and molybdenum complexes.
Reaction of [MoO(2)(acac)(2)] (where, acac=acetyl acetone) and KVO(3) with 2-(salicylidieneimine) benzimidazole lead to form new complexes [MoO(2)(sal-BMZ)(2)] and K [VO(2)(sal-BMZ)(2)] [where, sal-BMZ=2-(salicylidieneimine) benzimidazole], which showed the monobasic bidentate nature of the ligand in which the phenolic oxygen and the imine nitrogen of the ligand are coordinated to the metal ion. These complexes were characterized along with nine other complexes of oxoperoxovanadium (V), molybdenum (Vl) and tungsten (Vl) with benzimidazole derivatives and screened in vitro by micro dilution technique for their amoebicidal activity with a view to search for a more effective agent against Entamoeba histolytica suggests that compound 2 and 3 might be endowed with important antiamoebic properties since they showed IC(50 )values in a microM range.
Bharti
Neelam
N
Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, -110025, New Delhi, India.
Shailendra
Gonzalez Garza
M T
MT
Cruz-Vega
Delia E
DE
Castro-Garza
J
J
Saleem
Kishwar
K
Naqvi
Fehmida
F
Maurya
Mannar R
MR
Azam
Amir
A
D000563:Amebicides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D004748:Entamoeba histolytica / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008024:Ligands; D008982:Molybdenum / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014639:Vanadium / Q000737:chemistry
D000563:Amebicides; D001562:Benzimidazoles; D008024:Ligands; D009942:Organometallic Compounds; D014639:Vanadium; D008982:Molybdenum