New insights into the regulation and functions of Tec family tyrosine kinases in the immune system.
The Tec family of protein tyrosine kinases play an important role in signaling through antigen-receptors such as the TCR, BCR and Fcepsilon receptor. Recent studies have generated new insights into the domains in Tec kinases that take part in intramolecular and intermolecular binding. Furthermore, the consequences of these domain interactions for Tec activation and downregulation have been better defined. Genetic studies of kinase-knockout mice have emphasized the importance of Tec kinases in lymphocyte development, differentiation and apoptosis.
Miller
Andrew T
AT
Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical Center, Worcester, MA 01655, USA.
Berg
Leslie J
LJ
D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D004789:Enzyme Activation; D006801:Humans; D007527:Isoenzymes / Q000502:physiology; D008214:Lymphocytes / Q000502:physiology*; D051379:Mice; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D051966:Phospholipase C gamma; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000502:physiology*; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D010738:Type C Phospholipases / Q000502:physiology; D018909:src Homology Domains
D007527:Isoenzymes; D011948:Receptors, Antigen, T-Cell; D019869:Phosphatidylinositol 3-Kinases; C089848:Tec protein-tyrosine kinase; D011505:Protein-Tyrosine Kinases; C080813:emt protein-tyrosine kinase; D010738:Type C Phospholipases; D051966:Phospholipase C gamma