title: Regulation of plasma adenosine levels in normal pregnancy.
abstract: The aim of this study was to investigate the possible mechanism of the regulation of plasma adenosine concentration [ADO] in normal pregnancy. We measured the activities of circulating enzymes that are involved in the production and metabolism of adenosine, and plasma [ADO] in nonpregnant (n = 14) and normal pregnant women (n = 14) in the third trimester. In pregnant women, the activity of plasma 5'-nucleotidase and plasma [ADO] were significantly elevated and plasma adenosine deaminase activity was significantly reduced. Enzymatic activities of both plasma enzymes appear to be changed in a way that would favor increased adenosine concentrations.
authors.affiliation: Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan. yoshi-1@nms.ac.jp
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yoneyama
authors.forename: Rintaro
authors.initials: R
authors.lastname: Sawa
authors.forename: Shunji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishino
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miura
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Kuwabara
authors.forename: Toyohiko
authors.initials: T
authors.lastname: Kuwajima
authors.forename: Naoko
authors.initials: N
authors.lastname: Ito
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kiyokawa
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Otsubo
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Araki
mesh_terms: D015720:5'-Nucleotidase; D000241:Adenosine / Q000097:blood*; D000243:Adenosine Deaminase / Q000097:blood; D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*
chemical_list: D015720:5'-Nucleotidase; D000243:Adenosine Deaminase; D000241:Adenosine