Characterization of a laboratory-derived, high-level ampicillin-resistant Salmonella enterica serovar Typhimurium strain that caused meningitis in an infant.
A Salmonella enterica serovar Typhimurium strain that harbored a plasmid carrying a TEM-1-type beta-lactamase gene was isolated from the blood and cerebrospinal fluid of an infant with meningitis. This 3.2-kb plasmid was further characterized to be a nonconjugative pGEM series cloning vector containing a foreign insert. The strain was likely laboratory derived and contaminated the environment before it caused the infection.
Chiu
Cheng-Hsun
CH
Department of Pediatrics, Chang Gung Children's Hospital, Kweishan 333, Taoyuan, Taiwan.
Chu
Chishih
C
Su
Lin-Hui
LH
Wu
Wan-Yu
WY
Wu
Tsu-Lan
TL
D000667:Ampicillin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005818:Genetic Engineering; D005822:Genetic Vectors; D006801:Humans; D007223:Infant; D007753:Laboratories; D016920:Meningitis, Bacterial / Q000382:microbiology*; D010406:Penicillins / Q000494:pharmacology*; D010957:Plasmids; D012480:Salmonella Infections / Q000382:microbiology; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D001618:beta-Lactamases / Q000235:genetics
D010406:Penicillins; D000667:Ampicillin; D001618:beta-Lactamases; C034413:beta-lactamase TEM-1