Expression of super cervical ganglion-10 (SCG-10) mRNA in the monkey cerebral cortex during postnatal development.
We used Northern blot analysis to measure SCG10 mRNA expression in various areas of the monkey cerebral cortex during postnatal development. In all areas, SCG10 mRNA expression was highest immediately after birth, decreased sharply until postnatal day 70 (P70) and then decreased slowly until the adult stage. Expression levels were similar in all areas at all time points during development, including the adult stage. These findings confirm that axonal growth in the monkey cerebral cortex is most vigorous before or during the perinatal period, progresses similarly in all areas until P70, and continues at lower levels during late development.
Oishi
Takao
T
Systems Neuroscience Group, Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, Umezono, Tsukuba, Ibaraki 305-8568, Japan. t.oishi@aist.go.jp
Higo
Noriyuki
N
Matsuda
Keiji
K
Hayashi
Motoharu
M
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002540:Cerebral Cortex / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*; D019922:GAP-43 Protein / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000235:genetics; D008251:Macaca / Q000254:growth & development* / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D009414:Nerve Growth Factors / Q000235:genetics*; D016501:Neurites / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D013003:Somatosensory Cortex / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D014793:Visual Cortex / Q000166:cytology / Q000254:growth & development / Q000378:metabolism
D019922:GAP-43 Protein; D009414:Nerve Growth Factors; D012333:RNA, Messenger; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases