[Effect of modified low density lipoproteins on humoral immune response and functional activity of macrophages in mice].
Intravenous injection of acetylated low density lipoproteins (acLDL) in mice in a dose of 0.5 mg per mouse decreased the intensity of humoral immune response to sheep red blood cells (SRBC) by 35%. The addition of acLDL to mouse peritoneal macrophages in vitro resulted in inhibition of Fc-dependent phagocytosis of SRBC and fourfold increased secretion of prostaglandins E2 by macrophages. Fc-dependent phagocytosis of SRBC was also found to be inhibited by oxysterols (25-hydroxycholesterol and 7-ketocholesterol), added to the incubation medium of macrophages in vitro in doses of 0.5-5 mg/ml. The conclusion was made that oxidative metabolism of cholesterol and arachidonic acid, contained in LDL, may mediate the immunomodulating effects of modified LDL.
Poveshchenko
A F
AF
Institute of Clinical Immunology, Institute of Therapy, Siberian Branch, Russian Acad. Med. Sci., Novosibirsk, Russia.
Perminova
O M
OM
Dushkin
M I
MI
Kuznetsov
P O
PO
Vol'skiĭ
N N
NN
Kozlov
V A
VA
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000276:immunology* / Q000494:pharmacology*; D008262:Macrophage Activation / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice
D000276:Adjuvants, Immunologic; D008077:Lipoproteins, LDL; C032629:acetyl-LDL