title: Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury.
abstract: Fractalkine (FKN), also known as neurotactin, is a CX(3)C chemokine that exists in both secreted and neuronal membrane-bound forms and is upregulated during brain inflammation. There is accumulating evidence that FKN induces chemotaxis by binding to its receptor CX(3)CR1 on leukocytes and microglia. We generated FKN-deficient mice to study the role of FKN in postischemic brain injury. After transient focal cerebral ischemia, FKN-deficient mice had a 28% reduction in infarction size and lower mortality rate, when compared to wild-type littermates. The findings of this study indicate a possible role for FKN in augmenting postischemic injury and mortality after transient focal cerebral ischemia.
authors.affiliation: Department of Anesthesia, Children's Hospital, Boston, 300 Longwood Avenue, Boston, MA 02115, USA. sulpicio.soriano@tch.harvard.edu
authors.forename: Sulpicio G
authors.initials: SG
authors.lastname: Soriano
authors.forename: Lakshmi S
authors.initials: LS
authors.lastname: Amaravadi
authors.forename: Yanming F
authors.initials: YF
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
authors.forename: Gary X
authors.initials: GX
authors.lastname: Yu
authors.forename: James R
authors.initials: JR
authors.lastname: Tonra
authors.forename: Victoria
authors.initials: V
authors.lastname: Fairchild-Huntress
authors.forename: Qing
authors.initials: Q
authors.lastname: Fang
authors.forename: Judy H
authors.initials: JH
authors.lastname: Dunmore
authors.forename: Dennis
authors.initials: D
authors.lastname: Huszar
authors.forename: Yang
authors.initials: Y
authors.lastname: Pan
mesh_terms: D000818:Animals; D054428:Chemokine CX3CL1; D020523:Chemokines, CX3C / Q000172:deficiency / Q000235:genetics* / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology; D015870:Gene Expression / Q000276:immunology; D020244:Infarction, Middle Cerebral Artery / Q000276:immunology / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000276:immunology* / Q000473:pathology; D008565:Membrane Proteins / Q000172:deficiency / Q000235:genetics* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D012333:RNA, Messenger / Q000032:analysis; D015427:Reperfusion Injury / Q000276:immunology* / Q000473:pathology
chemical_list: D054428:Chemokine CX3CL1; D020523:Chemokines, CX3C; C515539:Cx3cl1 protein, mouse; D008565:Membrane Proteins; D012333:RNA, Messenger