title: Dynamic sonography of pancreatic tumors: comparison with dynamic CT.
abstract: OBJECTIVE
  The aim of this study was to examine the usefulness of dynamic sonography in the characterization of pancreatic tumors.
  
  
  METHODS
  IV contrast-enhanced pancreatic sonography (dynamic sonography) with Levovist was performed in 43 patients with pancreatic mass lesions (32 with pancreatic adenocarcinomas, four with inflammatory pancreatic masses, three with islet cell tumors, two with serous cystadenomas, one with a solid and cystic tumor, and one with metastatic pancreatic cancer). We calculated a contrast index using a time-intensity curve: contrast index equals elevation of intensity in the tumor divided by elevation of intensity in the pancreatic parenchyma. We classified the tumors into three groups according to the contrast index: a slightly enhanced group (contrast index < 0.5), a moderately enhanced group (contrast index = 0.5-1.5), and a well-enhanced group (contrast index > 1.5), and we compared these results with those from dynamic CT.
  
  
  RESULTS
  The contrast indexes of 32 adenocarcinomas, four inflammatory pancreatic masses, three islet cell tumors, two serous cystadenomas, one solid and cystic tumor, and one metastatic tumor were, respectively, 0.12 +/- 0.095 (mean +/- SD), 0.54 +/- 0.420, 1.74 +/- 0.555, 1.09 +/- 1.380, 1.67, and 2.07. Thirty-five tumors, including all 32 adenocarcinomas, were classified in the slightly enhanced group, three were classified in the moderately enhanced group, and five were classified in the well-enhanced group. In 93% (40/43) of tumors, the grade of enhancement on dynamic sonography was closely correlated with the grade of enhancement on dynamic CT.
  
  
  CONCLUSIONS
  Dynamic sonography can assist in the characterization of pancreatic tumors.
authors.affiliation: Division of Digestive Organs, Department of Cancer Survey, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3, Nakamichi, Higashinari, Osaka, 537-8511, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Oshikawa
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tanaka
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ioka
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nakaizumi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hamada
authors.forename: Takashi
authors.initials: T
authors.lastname: Mitani
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D018273:Carcinoma, Islet Cell / Q000000981:diagnostic imaging*; D018293:Cystadenoma, Serous / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010181:Pancreatic Cyst / Q000000981:diagnostic imaging*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging*; D010195:Pancreatitis / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography