Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors.
Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. Mouse cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. In MCMV-resistant mice, this viral protein engages a related activating receptor (Ly49H) and confers host protection. These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen.
Arase
Hisashi
H
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA.
Mocarski
Edward S
ES
Campbell
Ann E
AE
Hill
Ann B
AB
Lanier
Lewis L
LL
D016475:3T3 Cells; D000818:Animals; D000950:Antigens, Ly / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D002460:Cell Line; D018920:Coculture Techniques; D004198:Disease Susceptibility; D019143:Evolution, Molecular; D006566:Herpesviridae Infections / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006825:Hybridomas; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology*; D037181:Lectins, C-Type; D008024:Ligands; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D018146:Muromegalovirus / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D055650:NK Cell Lectin-Like Receptor Subfamily A; D011485:Protein Binding; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D055630:Receptors, NK Cell Lectin-Like; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D014162:Transfection; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism
D000950:Antigens, Ly; D015395:Histocompatibility Antigens Class I; C527096:Klra8 protein, mouse; D037181:Lectins, C-Type; D008024:Ligands; C408248:Ly49I antigen; D008562:Membrane Glycoproteins; D055650:NK Cell Lectin-Like Receptor Subfamily A; D011971:Receptors, Immunologic; D055630:Receptors, NK Cell Lectin-Like; D011993:Recombinant Fusion Proteins; D014764:Viral Proteins; D007371:Interferon-gamma