Beneficial effects of long-term administration of ONO-3144, a free radical scavenger, on stroke-prone SHR.
To clarify the preventive effects of ONO-3144, a free radical scavenger, on stroke-prone spontaneously hypertensive rats (SHRSP) and free radicals related to the hypertensive disorders.


METHODS
Drugs with powdered chow were administered orally to the rats from 2- to 14-month-old. Body weight, blood pressure, rectal temperature, oxygen consumption rate, thyroid hormones, lipids, platelet number, ocular fundus, autopsy, and life span were investigated.


RESULTS
ONO-3144 did not affect the growth, blood pressure, concentrations of thyroid hormones and lipids in the blood, but decreased the rectal temperature and oxygen consumption rate. ONO-3144 also prevented the platelet number decrease, sclerotic change of retinal artery, edematous and hypertrophic changes in parenchymal and circulatory organs. Both the average life-span and the longest life time of SHRSP given 40 mg/kg ONO-3144 were longer than those of normotensive rats and no administration hypertensive rats.


CONCLUSIONS
The oxidative f ree radicals closely relate to hypertension-induced pathophysiological changes in SHRSP, and ONO-3144 prevents the changes of those disorders, and then brings longevity.
Higashino
Hideak
H
Department of Pharmacology, Kinki University School of Medicine, Osak a-Sayama, Osaka 589-8511, Japan. higasino@med.kindai.ac.jp.
Maeda
Kana
K
Kawamoto
Masazumi
M
Endo
Hiroshi
H
Lee
Wen-Hsiung
WH
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000473:pathology / Q000517:prevention & control; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000627:therapeutic use*; D006973:Hypertension / Q000473:pathology / Q000517:prevention & control*; D008136:Longevity / Q000187:drug effects; D008297:Male; D011427:Propiophenones / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012161:Retinal Artery / Q000473:pathology; D020521:Stroke / Q000517:prevention & control*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016166:Free Radical Scavengers; D011427:Propiophenones; C037467:2-aminomethyl-4-tert-butyl-6-propionylphenol