title: Total synthesis of hectochlorin.
abstract: Hectochlorin (1) is a marine natural product with significant fungicidal activity. A synthesis effort was initiated to develop a flexible route to hectochlorin which would allow access to analogues with potentially improved activity and/or attributes relative to the natural product. A successful total synthesis of hectochlorin is described. [structure: see text]
authors.affiliation: Discovery Research, Dow AgroSciences LLC, Indianapolis, IN 46268, USA. jrpcetusic@dow.com
authors.forename: Jeannie R P
authors.initials: JR
authors.lastname: Cetusic
authors.forename: Frederick R
authors.initials: FR
authors.lastname: Green
authors.forename: Paul R
authors.initials: PR
authors.lastname: Graupner
authors.forename: M Paige
authors.initials: MP
authors.lastname: Oliver
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis*; D002384:Catalysis; D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis*; D013844:Thiazoles / Q000138:chemical synthesis*
chemical_list: D000935:Antifungal Agents; D007202:Indicators and Reagents; D007783:Lactones; D013844:Thiazoles; C454807:hectochlorin