title: New partially degradable and bioactive acrylic bone cements based on starch blends and ceramic fillers.
abstract: This work reports the development of new partially biodegradable acrylic bone cements based on corn starch/cellulose acetate blends (SCA), prepared by the free radical polymerization of methyl methacrylate and acrylic acid at low temperature. Amounts of biocompatible, osteoconductive and osteophilic mineral component such as hydroxylapatite (sintered and non-sintered), were incorporated in different percentages to confer a bone-bonding character to the bone cements in this type of applications. All cement formulations were characterized by 1H NMR spectroscopy. Curing parameters and mechanical properties were determined finding formulations which complete the ASTM legislation. Hydration degree, degradation studies, as well as bioactivity tests were performed in all prepared formulations. The developed systems show a range of properties that might allow for their application as self-curing bone cements, exhibiting several advantages with respect to other commercially available bone cements.
authors.affiliation: Department of Polymer Engineering, University of Minho, Braga, Portugal.
authors.forename: Ismael
authors.initials: I
authors.lastname: Espigares
authors.forename: Carlos
authors.initials: C
authors.lastname: Elvira
authors.forename: João F
authors.initials: JF
authors.lastname: Mano
authors.forename: Blanca
authors.initials: B
authors.lastname: Vázquez
authors.forename: Román J
authors.initials: RJ
authors.lastname: San
authors.forename: Rui L
authors.initials: RL
authors.lastname: Reis
mesh_terms: D001843:Bone Cements / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D013314:Stress, Mechanical; D013696:Temperature; D013997:Time Factors; D014867:Water / Q000378:metabolism
chemical_list: D001843:Bone Cements; D014867:Water; D019904:Polymethyl Methacrylate