title: Experience with insulin analogues in children.
abstract: Current data on rapid and long-acting insulin analogues in the paediatric age group is limited. While several studies indicate a benefit in reducing hypoglycaemia, particularly at night, with rapid or long-acting insulin analogue treatment, the effect on long-term glycaemic control remains controversial. The continuous glucose monitoring system offers a new option for tailoring treatment with insulin analogues to achieve optimal glycaemia. In 29 adolescents with diabetes this approach confirmed the non-inferiority of postprandial rapid-acting analogue administration compared to preprandial regular insulin, but revealed significant mealtime differences, with increased analogue requirement at breakfast and dinner. Although rapid- and long-acting insulin analogues may offer potential benefits for problems frequently encountered in paediatric diabetology, their value for the individual child still has to be tested in long-term observations in daily clinical practice.
authors.affiliation: Diabetes-Zentrum für Kinder und Jugendliche, Kinderkrankenhaus auf der Bult, Hannover, Germany. danne@hka.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Danne
authors.forename: Dorothee
authors.initials: D
authors.lastname: Deiss
authors.forename: Werner
authors.initials: W
authors.lastname: Hopfenmüller
authors.forename: Wolfgang
authors.initials: W
authors.lastname: von Schütz
authors.forename: Olga
authors.initials: O
authors.lastname: Kordonouri
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000503:physiopathology; D004338:Drug Combinations; D006801:Humans; D007260:Infusion Pumps; D007328:Insulin / Q000031:analogs & derivatives*; D012449:Safety
chemical_list: D001786:Blood Glucose; D004338:Drug Combinations; D007328:Insulin