Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats.
Idarubicin-loaded solid lipid nanoparticles (IDA-SLN) and idarubicin in solution were prepared and the two formulations were administered to rats, either by the duodenal route or intravenously (iv). The aim of this research was to study whether the bioavailability of idarubicin can be improved by administering IDA-SLN duodenally to rats. Idarubicin and its main metabolite idarubicinol were determined in plasma and tissues by reversed-phase high-performance liquid chromatography. The pharmacokinetic parameters of idarubicin found after duodenal administration of the two formulations were different: area under the curve of concentration versus time (AUC) and elimination half-life were approximately 21 times and 30 times, respectively, higher after IDA-SLN administration than after the solution administration. Tissue distribution also differed: idarubicin and idarubicinol concentrations were lower in heart, lung, spleen, and kidneys after IDA-SLN administration than after solution administration. The drug and its metabolite were detected in the brain only after IDA-SLN administration, indicating that SLN were able to pass the blood-brain barrier. After iv IDA-SLN administration, the AUC of idarubicin was lower than after duodenal administration of the same formulation. Duodenal administration of IDA-SLN modifies the pharmacokinetics and tissue distribution of idarubicin. The IDA-SLN act as a prolonged release system for the drug.
Zara
Gian Paolo
GP
Dipartimento di Anatomia, Farmacologia e Medicina Legale, Università degli Studi di Torino, Via P. Giuria 9, I-10125 Turin, Italy.
Bargoni
Alessandro
A
Cavalli
Roberta
R
Fundarò
Anna
A
Vighetto
Daniela
D
Gasco
Maria Rosa
MR
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000097:blood; D004333:Drug Administration Routes; D004337:Drug Carriers; D004386:Duodenum; D015255:Idarubicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D036103:Nanotechnology; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions; D014018:Tissue Distribution
D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D012996:Solutions; C054440:idarubicinol; D015255:Idarubicin; D003630:Daunorubicin