Hemolytic uremic syndrome due to an altered factor H triggered by neonatal pertussis.
We report on a previously healthy newborn suffering from severe Bordetella pertussis infection who developed hemolytic uremic syndrome (HUS) a few weeks after the onset of whooping cough, with a fatal outcome. A factor H protein with abnormal mobility was found in the serum of the patient as analyzed by Western blotting, indicating that B. pertussis infection might have triggered HUS in a genetically predisposed patient.
Berner
Reinhard
R
University Children's Hospital, Mathildenstrasse 1, 79106 Freiburg, Germany. berner@kikli.ukl.uni-freiburg.de
Krause
Martin F
MF
Gordjani
Nader
N
Zipfel
Peter F
PF
Boehm
Norbert
N
Krueger
Marcus
M
Brandis
Matthias
M
Zimmerhackl
Lothar B
LB
D001886:Bordetella pertussis; D017242:Complement Factor H / Q000378:metabolism*; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D014917:Whooping Cough / Q000150:complications* / Q000276:immunology
C493495:CFH protein, human; D017242:Complement Factor H