Losartan-induced hepatic injury.
Losartan, an angiotensin II receptor antagonist, is widely used for the treatment of hypertension. Clinical experience with this drug has demonstrated that it is safe. Losartan-induced hepatic toxicity is extremely rare. We report a case of severe hepatic toxicity and fibrosis caused by losartan use, and we review four previously reported cases. Drug-induced hepatic injury may be seen during the treatment of hypertension by losartan and the clinician should be aware of this toxicity, especially during the initial phase of treatment.
Tabak
Fehmi
F
Department of Clinical Bacteriology and Infectious Diseases, Cerrahpasa Medical Faculty, Istanbul University, Beylerbeyi 81210 Istanbul, Turkey. fehmitabak@hotmail.com
Mert
Ali
A
Ozaras
Resat
R
Biyikli
Mithat
M
Ozturk
Recep
R
Ozbay
Gulsen
G
Senturk
Hakan
H
Aktuglu
Yildirim
Y
D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced*; D019808:Losartan / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged
D000959:Antihypertensive Agents; D019808:Losartan