Derrisin, a new rotenoid from Derris malaccensis plain and anti-Helicobacter pylori activity of its related constituents.
A new rotenoid, derrisin (1), together with 10 known rotenoids (2-11) were isolated from the roots of Derris malaccensis Plain. The structure of 1 was elucidated by spectroscopic analysis. Nine of the isolated rotenoids (3-11) showed antibacterial activity against Helicobacter pylori.
Takashima
Junko
J
Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, Aoba-ku, Yokohama 227-0033, Japan.
Chiba
Noriko
N
Yoneda
Kaisuke
K
Ohsaki
Ayumi
A
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D016480:Helicobacter pylori / Q000187:drug effects; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D006576:Heterocyclic Compounds, 4 or More Rings; C457249:derrisin