title: [Hereditary non-polyposis colorectal cancer (HNPCC)].
abstract: Hereditary non-polyposis colorectal cancer (HNPCC) is a type of hereditary colorectal cancer with autosomal dominant traits. Its causal genes are mismatch repair genes such as the hMSH2 and hMLH1 genes. Owing to its frequency, juvenile onset, and the outbreaks of multiple colorectal cancers and cancers occurring over multiple organs, it is recognized as a very important disease for the purpose of understanding not only colorectal cancers, but also other digestive cancers, and furthering pathological inquiry into the state of cancers in general.
authors.affiliation: Department of Surgery II, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan.
authors.forename: Seiichi
authors.initials: S
authors.lastname: Takenoshita
authors.forename: Kenichi
authors.initials: K
authors.lastname: Takita
mesh_terms: D020137:Base Pair Mismatch; D003082:Colectomy; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D004268:DNA-Binding Proteins; D006801:Humans; D018895:Microsatellite Repeats; D051718:MutS Homolog 2 Protein; D011506:Proteins / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein