Remarkably enhanced inhibitory effects of three-component hybrid liposomes including sugar surfactants on the growth of lung carcinoma cells.
Sugar parts play important roles in recognizing molecules on the cell membranes. We successfully produced sugar-type micellar surfactants, lactonoalkylamide (LacCn), for the first time. Spherical vesicles, three-component hybrid liposomes, were obtained after the sonication of the mixture of L-alpha-dimyristoyl-phosphatidylcholine (DMPC), Tween 20 and LacCn (DMPC:Tween 20:LacCn=65:7:28). It is noteworthy that high inhibitory effects of the three-component hybrid liposomes composed of DMPC, Tween 20, and LacCn (DMPC:Tween 20:LacCn=65:7:28) on the growth of glioma (U251) and lung adenocarcinoma (RERF-LC-OK) cells were attained in vitro without any drug, although no significant inhibitory effects of any individual component (DMPC, Tween 20, LacCn) or the two-component hybrid liposomes of DMPC and Tween 20 on the growth of tumor cells examined were obtained.
Ueoka
Ryuichi
R
Graduate Course of Applied Chemistry, Sojo University, Ikeda, Kumamoto, Japan. ueoka@life.sojo-u.ac.jp
Matsumoto
Yoko
Y
Hirose
Shigeru
S
Goto
Koichi
K
Goto
Masahiro
M
Furusaki
Shintaro
S
D000230:Adenocarcinoma / Q000473:pathology; D000577:Amides / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D005910:Glioma / Q000473:pathology; D006801:Humans; D007783:Lactones / Q000494:pharmacology* / Q000633:toxicity; D008081:Liposomes; D008175:Lung Neoplasms / Q000473:pathology; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011136:Polysorbates / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D014407:Tumor Cells, Cultured
D000577:Amides; D000970:Antineoplastic Agents; D007783:Lactones; D008081:Liposomes; D011136:Polysorbates; D013501:Surface-Active Agents; D004134:Dimyristoylphosphatidylcholine