Total synthesis of hectochlorin.
Hectochlorin (1) is a marine natural product with significant fungicidal activity. A synthesis effort was initiated to develop a flexible route to hectochlorin which would allow access to analogues with potentially improved activity and/or attributes relative to the natural product. A successful total synthesis of hectochlorin is described. [structure: see text]
Cetusic
Jeannie R P
JR
Discovery Research, Dow AgroSciences LLC, Indianapolis, IN 46268, USA. jrpcetusic@dow.com
Green
Frederick R
FR
Graupner
Paul R
PR
Oliver
M Paige
MP
D000935:Antifungal Agents / Q000138:chemical synthesis*; D002384:Catalysis; D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis*; D013844:Thiazoles / Q000138:chemical synthesis*
D000935:Antifungal Agents; D007202:Indicators and Reagents; D007783:Lactones; D013844:Thiazoles; C454807:hectochlorin