title: The effect of Gd-DTPA on T(1)-weighted choline signal in human brain tumours.
abstract: The influence of Gd-DTPA on T(1)-weighted (T(1)W) proton MR spectra has been investigated in 19 patients with histologically verified low (n = 13) or high-grade (n = 6) gliomas. Repeat measurements were performed on 9 patients (7 low-grade and 2 high-grade), with 28 examinations performed in total. Comparison of spectra obtained before and after 0.2 mmol/kg Gd-DTPA showed contrast agent induced broadening of the choline signal without significant signal area change. Lack of enhancement of the choline signal with the T(1)-weighted acquisitions implies that the contrast agent and the trimethylamine-containing species do not undergo significant direct interaction. Contrast agent induced changes in the choline signal observed in this and previous studies may, therefore, be attributable to T2*/susceptibility-based effects.
authors.affiliation: CRC Clinical MR Research Group, The Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton. Surrey, SM2 5PT, United Kingdom.
authors.forename: Philip S
authors.initials: PS
authors.lastname: Murphy
authors.forename: Andrzej S K
authors.initials: AS
authors.lastname: Dzik-Jurasz
authors.forename: Martin O
authors.initials: MO
authors.lastname: Leach
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Rowland
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis*; D002794:Choline / Q000032:analysis; D003287:Contrast Media / Q000494:pharmacology*; D019786:Gadolinium DTPA / Q000494:pharmacology*; D005910:Glioma / Q000175:diagnosis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D014867:Water
chemical_list: D003287:Contrast Media; D014867:Water; D019786:Gadolinium DTPA; D002794:Choline