title: Neonatal alloimmune thrombocytopenia with significant HLA antibodies.
abstract: A case of neonatal alloimmune thrombocytopenia (NAIT) secondary to human platelet antigen (HPA)-1a antibodies is reported. Additional multispecific HLA antibodies rendered volunteer donor platelet transfusions ineffective. Despite a high incidence of maternal HLA antibodies in the pregnant population, there is only one previous report of clinically significant HLA antibodies.
authors.affiliation: Department of Haematology, Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK. igrainger@bigfoot.com
authors.forename: J D
authors.initials: JD
authors.lastname: Grainger
authors.forename: G
authors.initials: G
authors.lastname: Morrell
authors.forename: J
authors.initials: J
authors.lastname: Yates
authors.forename: D
authors.initials: D
authors.lastname: Deleacy
mesh_terms: D000906:Antibodies / Q000276:immunology*; D016824:Antigens, Human Platelet / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D039661:Integrin beta3; D017713:Platelet Transfusion / Q000379:methods; D013921:Thrombocytopenia / Q000276:immunology* / Q000628:therapy
chemical_list: D000906:Antibodies; D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3