Imidazole-based ligands of the Src SH2 protein.
Starting from known Src SH2 inhibitors incorporating five-membered heterocycles or benzamide scaffolds, we prepared tetrasubstituted imidazole compounds able to interact with the pY, pY+1 and pY+3 binding sites of the Src SH2 protein. The synthesis and biological data are presented.
Deprez
Pierre
P
Aventis Pharma, Paris Research Center, Medicinal Chemistry, 102 route de Noisy, 93235 Cedex, Romainville, France. pierre.deprez@aventis.com
Mandine
Eliane
E
Vermond
Annie
A
Lesuisse
Dominique
D
D007093:Imidazoles / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D018909:src Homology Domains
D007093:Imidazoles; D008024:Ligands