[Experimental studies on histocompatibility of three bio-derived bones].
OBJECTIVE
To study the histocompatibility of three bio-derived bones.


METHODS
After treatment with different physical and chemical method, three bio-derived bones, the composite fully deproteinized bone (CFDB), partially deproteinized bone (PDPB) and partially decalcified bone (PDCB) were implanted into rabbits. The toxicity, immune response and subperiosteum osteogenesis of CFDB, PDPB and PDCB were studied through gross observation, serum antibody measurement, evaluation of local cellular immune response and HE staining.


RESULTS
The study showed that CFDB, PDPB and PDCB had no toxicity. They could conduct peripheral tissue to grow into them and had no harmful effect on subperiosteum osteogenesis. They could also promote cartilage and osteoid tissue derived from periosteum to calcify to new bone, and combine with the peripheral bone. The degree of immune response caused by them was in the sequence of PDCB > PDPB > CFDB.


CONCLUSIONS
The three bio-derived bones, CFDB, PDPB and PDCB have good histocompatibility.
Yang
Zhiming
Z
Department of Orthopedic Surgery, First University Hospital, West China University of Medical Sciences, Chengdu 610041, China.
Li
Yanlin
Y
Xie
Huiqi
H
Qin
Tingwu
T
Huang
Fuguo
F
D000818:Animals; D000906:Antibodies / Q000097:blood; D016025:Bone Transplantation; D001842:Bone and Bones / Q000276:immunology*; D005260:Female; D006648:Histocompatibility; D006650:Histocompatibility Testing; D008297:Male; D011817:Rabbits; D023822:Tissue Engineering
D000906:Antibodies