[Buspirone increases D2-like dopaminergic receptor density in rat corpus striatum].
Buspirone (busp) a piperazinyl derivative with anxiolytic properties is a partial agonist on 5-HT1A with affinity for D2-like dopaminergic receptors (RD2). The objective of this study was to verify the effects of busp on RD2. Female Wistar rats 150-200 g were treated with busp (5 and 10 mg/kg, p.o.) 1 or 2 times daily for 7 days. Controls (C) received saline. The density of RD2 (fmol/mg protein) was determined through binding assays in striatum (ST) using [3H]-spiroperidol as radioligand. No alteration in Bmax or Kd values were seen after busp administration once a day. However, a RD2 upregulation of 55 % increase was observed after busp 2 times a day with no change in Kd values. The results showed that busp interact not only with serotonergic, but also with dopaminergic system.
Lima
Vera Targino Moreira
VT
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Macedo
Danielle Silveira
DS
Nogueira
Carlos Renato Alves
CR
Vasconcelos
Silvânia Maria Mendes
SM
Viana
Glauce Socorro de Barros
GS
Sousa
Francisca Cléa Florenço de
FC
D000818:Animals; D002065:Buspirone / Q000008:administration & dosage / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000187:drug effects* / Q000378:metabolism; D018490:Serotonin Agents / Q000008:administration & dosage / Q000494:pharmacology*
D017448:Receptors, Dopamine D2; D018490:Serotonin Agents; D002065:Buspirone