Stevens-Johnson syndrome presumably induced by bromhexine. A case report.
The Stevens-Johnson syndrome is a serious form of erythema multiforme, an acute inflammatory pathology with an autoimmune pathogenesis. Its etiology is unknown, although it is thought to have multifactorial causes; nonetheless, many drugs are thought to induce such an immune response. The clinical symptomatology is mainly muco-cutaneous, with a remarkable oral involvement. The authors describe here a case of Stevens-Johnson syndrome involving the ocular, oral, and genital areas, presumably induced by the bromhexine administered to the patient for a viral syndrome.
Cafasso
A
A
Dipartimento di Odontoiatria e Stomatologia, Presidio Ospedaliero Ascalesi, Naples, Italy.
Rao
F
F
Mucciarone
L
L
Ambrosino Di Miccio
S
S
D000328:Adult; D000871:Anthelmintics / Q000627:therapeutic use; D001964:Bromhexine / Q000009:adverse effects*; D005100:Expectorants / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology; D009930:Organic Chemicals; D010413:Penis / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology
D000871:Anthelmintics; D005100:Expectorants; D009930:Organic Chemicals; C407664:deltacortene; D001964:Bromhexine