title: Effects of stereochemical aspects on drug interaction in pharmacokinetics.
abstract: Recent literatures on enantiomer/enantiomer and enantiomer/coadministered drug interactions in pharmacokinetics were reviewed. The clinical significance of introducing the concept of stereoselectivity into pharmacokinetic interaction study cannot be overestimated, such as avoiding interaction-based adverse reactions, increasing therapeutic index, resolving the apparent anomaly in the plasma concentration-effect relationship and providing starting point of investigation into drug disposition, etc. Study in this respect should be enhanced.
authors.affiliation: Department of Drug Metabolism & Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhou
authors.forename: Tong-Wei
authors.initials: TW
authors.lastname: Yao
authors.forename: Su
authors.initials: S
authors.lastname: Zeng
mesh_terms: D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010599:Pharmacokinetics; D013237:Stereoisomerism
chemical_list: D004364:Pharmaceutical Preparations