title: Gamma interferon fails to induce expression of indoleamine 2,3-dioxygenase and does not control the growth of Chlamydophila abortus in BeWo trophoblast cells.
abstract: The BeWo trophoblast cell line does not constitutively express the tryptophan degrading enzyme indolamine 2,3-dioxygenase (IDO), nor can IDO expression be induced by gamma interferon. This correlates with the inability of BeWo cells to control the growth of Chlamydophila abortus, in contrast to effects observed in HeLa cells treated with gamma interferon.
authors.affiliation: Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh EH26 0PZ, Scotland, United Kingdom. gary.entrican@mri.sari.ac.uk
authors.forename: Gary
authors.initials: G
authors.lastname: Entrican
authors.forename: Sean
authors.initials: S
authors.lastname: Wattegedera
authors.forename: Michelle
authors.initials: M
authors.lastname: Chui
authors.forename: Lyn
authors.initials: L
authors.lastname: Oemar
authors.forename: Mara
authors.initials: M
authors.lastname: Rocchi
authors.forename: Colin
authors.initials: C
authors.lastname: McInnes
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D023501:Chlamydophila / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity; D002691:Chlamydophila psittaci; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006367:HeLa Cells; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007371:Interferon-gamma / Q000494:pharmacology*; D011247:Pregnancy; D014327:Trophoblasts / Q000382:microbiology*; D014366:Tryptophan Oxygenase / Q000096:biosynthesis*; D014407:Tumor Cells, Cultured
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007371:Interferon-gamma; D014366:Tryptophan Oxygenase