Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat.
Substance P is known to exert various pro-inflammatory effects that are mediated by neurokinin-1 (NK-1) receptor in peripheral tissues. This study examined the effect of the NK-1 receptor antagonist cis-2-[diphenylmethyl]-N-[(2-iodophenyl)-1-azabicyclo[2.2.2]octan-3-amine] (L-703,606) on nociceptive response following carrageenan injection (2%, 50 microl) into the knee joint cavity of the right hind leg. L-703,606 injection (0.1 or 1 mM, 50 microl) into the same joint cavity immediately before the carrageenan injection significantly reduced the nociceptive response. However, antagonist treatment at 5 h after carrageenan injection was ineffective in alleviating nociception. Neither intraperitoneal injection of the antagonist (1 mM, 50 microl) immediately before the carrageenan injection was effective. These results suggest that local NK-1 receptor contributes to the induction, but not maintenance, of arthritic pain.
Hong
Seung Kil
SK
Department of Physiology, College of Medicine and Neuroscience Research Institute, Medical Science Research Center, Korea University, 126-1 Anam-dong 5 ga, Sungbuk-gu, Seoul 136-075, South Korea.
Han
Jeong Seok
JS
Min
Sun Seek
SS
Hwang
Jong Moon
JM
Kim
Yang In
YI
Na
Heung Sik
HS
Yoon
Young Wook
YW
Han
Hee Chul
HC
D000818:Animals; D001168:Arthritis / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D002351:Carrageenan / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007719:Knee Joint / Q000187:drug effects / Q000294:innervation* / Q000503:physiopathology; D008297:Male; D064729:Neurokinin-1 Receptor Antagonists; D009475:Neurons, Afferent / Q000187:drug effects / Q000378:metabolism; D009619:Nociceptors / Q000187:drug effects / Q000378:metabolism*; D010146:Pain / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D010525:Peripheral Nerves / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D011812:Quinuclidines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D016474:Weight-Bearing / Q000502:physiology
D064729:Neurokinin-1 Receptor Antagonists; D011812:Quinuclidines; D018040:Receptors, Neurokinin-1; C076851:L 703606; D013373:Substance P; D002351:Carrageenan