[Activity of elastase and its inhibitors in tissues of aorta and blood serum in various types of acidosis].
In modeling of different types of acidosis (hyperchloraemic, lactate and ketoacidosis in the starvation) at rats the elastase activity, contents of alpha-2 macroglobulin (alpha 2M) and alpha-1 proteinase inhibitor (alpha 1PI) in aorta tissues and blood serum were studied. The obtained results indicate that the degree of disturbance in system elastase-inhibitors depends on expressiveness of parameters changes in system of acid-base state regulation. In modeling of various types of acidosis coefficient inhibitors/elastase is reduced due to different parameters change in aorta, namely decrease of alpha 2M contents--in hyperchloraemic acidosis, increase of elastase activity--in lactat-acidosis, increase of elastase activity and decrease of alpha 2M contents--in ketoacidosis. In blood serum the similar coefficient is reduced due to increase of elastase activity and decrease of alpha 2M contents in hyperchloraemic acidosis and starvation, and, in turn, due to decrease of alpha 2M contents--in lactat-acidosis. The obtained data indicate that one of mechanisms of vascular wall damage in acidosis is disturbance of balance between elastase and its inhibitors in tissues of arteries.
Trofymova
I M
IM
A. A. Bogomoletz National Medical University, Kiev.
Dosenko
V Ie
VIe
Byts'
Iu V
IuV
D000138:Acidosis / Q000145:classification / Q000378:metabolism*; D000140:Acidosis, Lactic / Q000378:metabolism; D000643:Ammonium Chloride / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000201:enzymology* / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000097:blood / Q000378:metabolism; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism; D051381:Rats; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D004791:Enzyme Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D000643:Ammonium Chloride; D010196:Pancreatic Elastase