No major schizophrenia locus detected on chromosome 1q in a large multicenter sample.
Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.
Levinson
Douglas F
DF
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA. dfl@mail.med.upenn.edu
Holmans
Peter A
PA
Laurent
Claudine
C
Riley
Brien
B
Pulver
Ann E
AE
Gejman
Pablo V
PV
Schwab
Sibylle G
SG
Williams
Nigel M
NM
Owen
Michael J
MJ
Wildenauer
Dieter B
DB
Sanders
Alan R
AR
Nestadt
Gerald
G
Mowry
Bryan J
BJ
Wormley
Brandon
B
Bauché
Stephanie
S
Soubigou
Stephane
S
Ribble
Robert
R
Nertney
Deborah A
DA
Liang
Kung Yee
KY
Martinolich
Laura
L
Maier
Wolfgang
W
Norton
Nadine
N
Williams
Hywel
H
Albus
Margot
M
Carpenter
Eric B
EB
DeMarchi
Nicola
N
Ewen-White
Kelly R
KR
Walsh
Dermot
D
Jay
Maurice
M
Deleuze
Jean-François
JF
O'Neill
F Anthony
FA
Papadimitriou
George
G
Weilbaecher
Ann
A
Lerer
Bernard
B
O'Donovan
Michael C
MC
Dikeos
Dimitris
D
Silverman
Jeremy M
JM
Kendler
Kenneth S
KS
Mallet
Jacques
J
Crowe
Raymond R
RR
Walters
Marilyn
M
D000349:Africa; D000483:Alleles; D001315:Australia; D002170:Canada; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D005060:Europe; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D014481:United States