Association between IL-4 genotype and IL-4 production in the Japanese population.
We have identified that there are only two IL-4 gene haplotypes (I and II) in the Japanese population. There are significant differences among three genotypes (I/I, I/II and II/II) in the IL-4 producing proportion of peripheral Th cells using intracellular cytokine detection assay. These results make it likely that IL-4 genotype could influence the type of immune response.
Nakashima
H
H
Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. hnakashi@intmed1.med.kyushu-u.ac.jp
Miyake
K
K
Inoue
Y
Y
Shimizu
S
S
Akahoshi
M
M
Tanaka
Y
Y
Otsuka
T
T
Harada
M
M
D002478:Cells, Cultured; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015847:Interleukin-4 / Q000096:biosynthesis* / Q000235:genetics*; D007564:Japan; D011110:Polymorphism, Genetic; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D015847:Interleukin-4