title: New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata.
abstract: Three new monotetrahydrofuran annonaceous acetogenins, muricin H (1), muricin I (2), and cis-annomontacin (3), along with five known acetogenins, annonacin, annonacinone, annomontacin, murisolin, and xylomaticin, were isolated from the seeds of Annona muricata. Additionally, two new monotetrahydrofuran annonaceous acetogenins, cis-corossolone (4) and annocatalin (5), together with four known ones, annonacin, annonacinone, solamin, and corossolone, were isolated from the leaves of this species. The structures of all new isolates were elucidated and characterized by spectral and chemical methods. These new acetogenins exhibited significant activity in in vitro cytotoxic assays against two human hepatoma cell lines, Hep G(2) and 2,2,15. Compound 5 showed a high selectivity toward the Hep 2,2,15 cell line.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
authors.forename: Chih-Chuang
authors.initials: CC
authors.lastname: Liaw
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Chih-Yuan
authors.initials: CY
authors.lastname: Lin
authors.forename: Chi-Jung
authors.initials: CJ
authors.lastname: Chou
authors.forename: Hui-Fen
authors.initials: HF
authors.lastname: Chiu
authors.forename: Ming-Jung
authors.initials: MJ
authors.lastname: Wu
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000970:Antineoplastic Agents; D006528:Carcinoma, Hepatocellular; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D002942:Circular Dichroism; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D005663:Furans; D007783:Lactones; C455171:annocatalin; C455172:corossolone; C455169:muricin H; C455170:muricin I; C073066:annomontacin