[Anticonvulsant and forced swim anti-immobility effects of tetrahydro-N, N-dimethyl-2,2-diphenyl-3-furanemethanamine (AE37): common action mechanism?].
Tetrahydro-N, N-dimethyl-2, 2-diphenyl-3-furanemethanamine (AE 37) is a newly synthesized anticonvulsant drug efficient against electrogenic (maximal electroshock: MES) or pentetrazole (PTZ) induced tonic convulsions of mice. It also antagonizes the immobility of adult or aged mice in the forced swim test (FST), which is used to detect antidepressive properties. Neurochemical changes induced by AE37 (antagonistic action on the sodium channel currents and on the receptors sensitive to N-methyl-D-aspartic acid) could generate the aforementioned pharmacological properties, whereas the partial agonistic action of AE 37 on the brain muscarinic receptors seems to confer to this drug characteristics of third generation antiepileptic.
Vamvakidès
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Laboratoire de Pharmacologie Expérimentale, Faculté de Médecine d'Athènes, Grèce.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D005663:Furans / Q000494:pharmacology; D006801:Humans; D051379:Mice; D013550:Swimming / Q000523:psychology
D000927:Anticonvulsants; D000928:Antidepressive Agents; D005663:Furans; C458800:tetrahydro-N, N-dimethyl-2,2-diphenyl-3-furanemethanamine