Invasive filamentous growth of Candida albicans is promoted by Czf1p-dependent relief of Efg1p-mediated repression.
Filamentation of Candida albicans occurs in response to many environmental cues. During growth within matrix, Efg1p represses filamentation and Czf1p relieves this repression. We propose that Czf1p interacts with Efg1p, altering its function. The complex regulation of filamentation may reflect the versatility of C. albicans as a pathogen.
Giusani
Angela D
AD
Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111, USA.
Vinces
Marcelo
M
Kumamoto
Carol A
CA
D002176:Candida albicans / Q000235:genetics / Q000254:growth & development*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology*; D013696:Temperature; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D020798:Two-Hybrid System Techniques
D004268:DNA-Binding Proteins; C121438:EFG1 protein, Candida albicans; D005656:Fungal Proteins; D014157:Transcription Factors; C077336:CZF1 protein, Candida albicans