title: Enantioselective monoreduction of 2-alkyl-1,3-diketones mediated by chiral ruthenium catalysts. dynamic kinetic resolution.
abstract: The reduction of 2-alkyl-1,3-diketones using (R,R)- or (S,S)-RuCl[N-(tosyl)-1,2-diphenylethylenediamine](p-cymene) in the presence of formic acid and triethylamine affords syn-2-alkyl-3-hydroxy ketones as the major products with high enantioselectivity. [reaction: see text]
authors.affiliation: Laboratoire de Chimie Organique associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Eustache
authors.forename: Peter I
authors.initials: PI
authors.lastname: Dalko
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy