title: [Recurrence of thymoma accompanied with hypogammaglobulinemia 20 years after surgery: a case report].
abstract: We reported a case of recurrence of localized thymoma accompanied with hypogammaglobulinemia (Good's syndrome) 20 years after surgery. A 74-year-old man was admitted to this hospital because of mediastinal tumor and chronic pulmonary infection. He had been thymectomised at the age of 55 because of spindle cell thymoma. After that, he had been asymptomatic until January 1997, when he began to have a recurrent productive cough, and low-grade fever. Laboratory findings revealed hypogammaglobulinemia. Percutaneous needle biopsy of the mediastinal tumor revealed spindle cell thymoma. Therefore, hypogammaglobulinemia with thymoma (Good's syndrome) accompanied with a chronic lower respiratory tract infection was diagnosed. Immunologic studies revealed a marked decrease of CD 20 positive cells and decreased lymphocyte activation under the stimuli of phytohemagglutinin and concanavalin A. The thymoma was resected in Dec 1997, but the serum immunoglobulin showed no increase at al.
authors.affiliation: Second Department of Internal Medicine, Nagoya City University Medical School.
authors.forename: Taio
authors.initials: T
authors.lastname: Naniwa
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kakihara
authors.forename: Shuji
authors.initials: S
authors.lastname: Zen-nami
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomita
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Sugiura
authors.forename: Takeo
authors.initials: T
authors.lastname: Yoshinouchi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sato
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Ueda
mesh_terms: D000361:Agammaglobulinemia / Q000150:complications*; D000368:Aged; D006801:Humans; D008297:Male; D012008:Recurrence; D013945:Thymoma / Q000150:complications* / Q000601:surgery; D013953:Thymus Neoplasms / Q000150:complications* / Q000601:surgery; D013997:Time Factors