title: Locally advanced mucinous carcinoma of the breast with sudden growth acceleration: a case report.
abstract: We report a 35-year-old woman with locally advanced mucinous carcinoma of the breast with sudden growth acceleration. A pea-sized mass developed into an ulcerated large tumor within 1 month. After the combination of chemotherapy, radiation and hyperthermia, a radical mastectomy was performed, followed by repair of the skin defect by latissimus dorsi and rectus abdominis musculocutaneous flaps. Histological examination revealed a pure mucinous carcinoma with axillary lymph node involvement. Estrogen and progesterone receptors were not detected in the tumor. Twenty-five months after treatment, there is no sign of recurrent disease. Pure mucinous carcinoma generally has a less aggressive growth pattern as defined by tumor size, adherence to the overlying skin/bottom fasciae, estrogen and progesterone receptor positive and primary lymph axillary lymph node metastases. This case showed completely opposite features to all of these typical biological features of pure mucinous carcinomas.
authors.affiliation: Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan. tak55@med.yokohama-ac.cu.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Yohei
authors.initials: Y
authors.lastname: Hamaguchi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: Miei
authors.initials: M
authors.lastname: Shimura
authors.forename: Naomi
authors.initials: N
authors.lastname: Kawano
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nakatani
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohnishi
authors.forename: Jiro
authors.initials: J
authors.lastname: Maegawa
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ogino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimada
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D015409:Mastectomy, Radical; D017239:Paclitaxel / Q000008:administration & dosage; D011879:Radiotherapy Dosage
chemical_list: D004317:Doxorubicin; C027260:pirarubicin; D017239:Paclitaxel