title: Immunohistochemical localization of androgen and oestrogen receptors in canine hair follicles.
abstract: Skin biopsies from seven different body sites were obtained from 21 dogs of different breeds (short, normal, long hair), which were presented for euthanasia. Commercially available polyclonal antibodies were used for the immunohistochemical detection of androgen and oestrogen receptors. Both receptors showed a similar distribution in canine skin, with specific intranuclear staining. In the epidermis, the percentage of androgen receptor (AR)-positive cells, but not that of oestrogen receptor (ER)-positive cells, was significantly higher in samples from the thorax and the flank. In the dermal papilla, the percentage of ER-positive (but not AR-positive) cells was significantly lower in biopsies from the flank. No significant difference was found for both receptors between the locations in the outer root sheath, among the three different hair types, between sex and between intact and castrated dogs.
authors.affiliation: Institut für Biochemie und Ludwig Boltzmann institut für Veterinärmedizinische Universität Wien, Veterinärplatz 1, A-1210, Austria.
authors.forename: Christine B
authors.initials: CB
authors.lastname: Bratka-Robia
authors.forename: Monika
authors.initials: M
authors.lastname: Egerbacher
authors.forename: Magdalena
authors.initials: M
authors.lastname: Helmreich
authors.forename: Gerda
authors.initials: G
authors.lastname: Mitteregger
authors.forename: Michael
authors.initials: M
authors.lastname: Benesch
authors.forename: Elmar
authors.initials: E
authors.lastname: Bamberg
mesh_terms: D000818:Animals; D004285:Dogs / Q000378:metabolism*; D005260:Female; D018859:Hair Follicle / Q000378:metabolism*; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D011944:Receptors, Androgen / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*
chemical_list: D011944:Receptors, Androgen; D011960:Receptors, Estrogen