Identification of components of Prunus africana extract that inhibit lipid peroxidation.
Extractive and chromatographic separations were performed on V-1326, a chloroform extract from the bark of Prunus africana (also referred to as Pygeum africanum), which is used to treat the symptoms associated with benign prostate hyperplasia (BPH). The relative amounts of eleven identified constituents in crude V-1326 and in separated fractions were determined using gas chromatographic analysis. The ability of V-1326 and its separated fractions to inhibit ferrous ion-induced stimulation of lipid peroxidation in microsomal preparations from rabbit livers was evaluated. The extract, V-1326, and fractions containing high levels of myristic acid potently inhibited lipid peroxidation.
Hass
M A
MA
Division of Basic and Pharmaceutical Sciences, Albany College of Pharmacy, NY 12208, USA. hassm@panther.acp.edu
Nowak
D M
DM
Leonova
E
E
Levin
R M
RM
Longhurst
P A
PA
D001681:Biological Assay; D002849:Chromatography, Gas; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation / Q000187:drug effects*; D019814:Myristic Acid; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology*; D027861:Prunus / Q000737:chemistry*
D010936:Plant Extracts; D019814:Myristic Acid