title: Passive immunization with bovine milk containing antibodies to a cell surface protein antigen-glucosyltransferase fusion protein protects rats against dental caries.
abstract: Cell surface protein antigen (PAc) and glucosyltransferases (GTF) of Streptococcus mutans are major colonization factors of the organism. We prepared bovine milk containing antibodies against a fusion of the saliva-binding alanine-rich region of PAc with the glucan-binding domain of GTF-I. This study examined the effect of the immune milk on the cariogenicity of S. mutans in a rat model. Concentrated immune milk was fed to rats once a day for 55 days. The group that received immune milk had significantly less caries development than controls.
authors.affiliation: Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, Japan.
authors.forename: Morihide
authors.initials: M
authors.lastname: Mitoma
authors.forename: Takahiko
authors.initials: T
authors.lastname: Oho
authors.forename: Naoko
authors.initials: N
authors.lastname: Michibata
authors.forename: Kaoru
authors.initials: K
authors.lastname: Okano
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nakano
authors.forename: Masataka
authors.initials: M
authors.lastname: Fukuyama
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Koga
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D002417:Cattle; D003731:Dental Caries / Q000517:prevention & control*; D005964:Glucosyltransferases / Q000276:immunology*; D007116:Immunization, Passive; D008297:Male; D008562:Membrane Glycoproteins; D008892:Milk / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011993:Recombinant Fusion Proteins / Q000276:immunology*; D013295:Streptococcus mutans / Q000201:enzymology / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D008562:Membrane Glycoproteins; D011993:Recombinant Fusion Proteins; C055764:S-layer proteins; D005964:Glucosyltransferases