A novel role of RGS9: inhibition of retinal guanylyl cyclase.
Cyclic GMP plays a key role in retinal phototransduction and its photoreceptor concentration is precisely controlled by the cooperative action of cGMP phosphodiesterase (PDE) and retinal guanylyl cyclase (retGC). However, studies of the relationship between these two systems have focused only on a Ca2+-mediated, indirect connection. This article summarizes our studies strongly suggesting that RGS9-1 is directly involved in the cooperative action of PDE and retGC, and that this ingenious mechanism plays an important role in tuning of cGMP concentration in photoreceptors.
Bondarenko
Vladimir A
VA
Kresge Eye Institute and Department of Ophthalmology, Wayne State University, School of Medicine, Detroit, MI 48201, USA. ayamazak@med.wayne.edu
Yu
Hao
H
Yamazaki
Russell K
RK
Yamazaki
Akio
A
D000818:Animals; D006160:Guanosine Triphosphate / Q000378:metabolism; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006868:Hydrolysis; D020710:RGS Proteins / Q000737:chemistry / Q000378:metabolism*; D012160:Retina / Q000201:enzymology*; D014785:Vision, Ocular
D020710:RGS Proteins; C116925:regulator of g-protein signaling 9; D006160:Guanosine Triphosphate; D006162:Guanylate Cyclase