title: [Telomerase activity and regulation in human neuroepithelial tumors].
abstract: OBJECTIVE
  To investigate telomerase activity and expression of hTR and hTERT in human neuroepithelial tumors for exploring new strategy for clinical diagnosis and treatment.
  
  
  METHODS
  Telomerase activity was detected by modified TRAP method and the expression of hTR and hTERT was measured by RT-PCR method in 65 human neuroepithelial tumors, respectively.
  
  
  RESULTS
  The positive rates of telomerase and hTERT were 61.54% and 70.77% respectively in human neuroepithelial tumors, and the positive rate and their level of expression were correlated with the degree of malignancy of tumors positively.
  
  
  CONCLUSIONS
  Telomerase activity and hTERT are significantly correlated with the degree of malignancyin human neuroepithelial tumors. hTERT may play a key role in the regulation of telomerase activity.
authors.affiliation: Department of Neurosurgery, Gereral Hospital, Tianjin Medical University, Tianjin, 300052, China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: You
authors.forename: Peiyu
authors.initials: P
authors.lastname: Pu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Peng
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Xia
authors.forename: Qiang
authors.initials: Q
authors.lastname: Huang
authors.forename: Chunyan
authors.initials: C
authors.lastname: Wang
authors.forename: Guangxiu
authors.initials: G
authors.lastname: Wang
mesh_terms: D004268:DNA-Binding Proteins; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018302:Neoplasms, Neuroepithelial / Q000201:enzymology* / Q000235:genetics; D019098:Telomerase / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D019098:Telomerase