title: [Corneal descompensation in patients with endothelial compromise treated with topical dorzolamide].
abstract: OBJECTIVE
  To investigate the possibility of corneal alterations in patients with long-term endothelial compromise with topical dorzolamide.
  
  
  METHODS
  Retrospective descriptive study of 17 patients with penetrating keratoplasty and glaucoma associated with topical carbonic anhydrase inhibitor therapy, looking for coincidence with corneal alteration.
  
  
  RESULTS
  Classified by ethiology, type of glaucoma and control, recording previous ophthalmological surgeries, evolution time, complications and rejection episodes. Seven patients suffered a corneal decompensation, in three of them there were signs of true reject but only four cases had edema at the beginning of dorzolamide treatment, one of them recovering after stopping dorzolamide. Risk factors were previous cataract surgery, mainly aphakia, filtering surgery and previous vitrectomy.
  
  
  CONCLUSIONS
  Dorzolamide could have a potential negative effect on patients with endothelial compromise.
authors.affiliation: Servicio de Oftalmología, Hospital General Universitario Gregorio Marañón, Madrid, España. domingoblanco@hotmail.com
authors.forename: B
authors.initials: B
authors.lastname: Domingo Gordo
authors.forename: J L
authors.initials: JL
authors.lastname: Urcelay Segura
authors.forename: J
authors.initials: J
authors.lastname: Conejero Arroyo
authors.forename: P
authors.initials: P
authors.lastname: Balado Vázquez
authors.forename: P
authors.initials: P
authors.lastname: Rodríguez Ausín
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects* / Q000601:surgery; D004728:Endothelium, Corneal / Q000187:drug effects; D018463:Filtering Surgery; D005901:Glaucoma / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013449:Sulfonamides / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*; D014821:Vitrectomy / Q000009:adverse effects
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide