title: Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid.
abstract: Caveolin-1 is a major structural component of caveolae, which are plasma membrane microdomains implicated in the regulation of intracellular signalling pathways. Previous in vitro and in vivo studies on the function of caveolin-1 in carcinoma showed controversial results, indicating that the physiological role of caveolin-1 varies according to the origin of carcinoma. In this study, we investigated caveolin-1 expression in thyroid neoplasms by means of immunohistochemistry using a rabbit polyclonal antibody against caveolin-1. Normal follicular cells did not express caveolin-1. In papillary carcinoma, caveolin-1 expression was observed in high incidence, and especially in microcancer (less than 1.0 cm in diameter), caveolin-1 was positive in all cases except one. In undifferentiated (anaplastic) carcinoma, its incidence was significantly reduced. On the other hand, all cases of follicular carcinoma and adenoma were classified as negative for caveolin-1. These results suggest that caveolin-1 may play a role predominantly in the early phase of papillary carcinoma, whereas it has little influence on follicular tumours.
authors.affiliation: Department of Surgery, Kuma Hospital, 8-2-35 Shimoyamate-dori, Chuo-ku, Kobe 650-0011, Japan. ito01@kuma-h.or.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Nakano
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Yokozawa
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: F
authors.initials: F
authors.lastname: Matsuzuka
authors.forename: N
authors.initials: N
authors.lastname: Matsuura
authors.forename: K
authors.initials: K
authors.lastname: Kakudo
authors.forename: K
authors.initials: K
authors.lastname: Kuma
authors.forename: A
authors.initials: A
authors.lastname: Miyauchi
mesh_terms: D000236:Adenoma / Q000737:chemistry; D002291:Carcinoma, Papillary / Q000737:chemistry* / Q000473:pathology; D051242:Caveolin 1; D022461:Caveolins / Q000032:analysis* / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D013964:Thyroid Neoplasms / Q000737:chemistry* / Q000473:pathology
chemical_list: C495540:CAV1 protein, human; D051242:Caveolin 1; D022461:Caveolins