title: The IL12B gene does not confer susceptibility to coeliac disease.
abstract: Coeliac disease (CD) is a chronic inflammatory disorder where dietary gluten is not tolerated. In the lesion there are gluten reactive T cells predominantly secreting gamma-interferon. Both HLA and non-HLA genes contribute to CD susceptibility. Interleukin-12 (IL-12) regulates gamma-interferon production. The IL12B gene is located in a region (5q31.1-33.1) where there is evidence for linkage with CD. Allele 1 of an IL12B 3'UTR single-nucleotide polymorphism leads to increased expression of IL-12, and was recently implicated in susceptibility for type 1 diabetes (T1D). We found no evidence for association of allele 1 to CD by the transmission/disequilibrium test or case-control approach. No increased frequency was observed in patients belonging to families where the disease was linked to markers on chromosome 5q. Unlike T1D, allele 1 does not appear to confer susceptibility to CD.
authors.affiliation: Institute of Immunology, University of Oslo Rikshospitalet, Oslo, Norway. andrew.louka@biotek.uio.no
authors.forename: A S
authors.initials: AS
authors.lastname: Louka
authors.forename: A
authors.initials: A
authors.lastname: Torinsson Naluai
authors.forename: S
authors.initials: S
authors.lastname: D'Alfonso
authors.forename: H
authors.initials: H
authors.lastname: Ascher
authors.forename: I
authors.initials: I
authors.lastname: Coto
authors.forename: J
authors.initials: J
authors.lastname: Ek
authors.forename: M
authors.initials: M
authors.lastname: Giordano
authors.forename: A H
authors.initials: AH
authors.lastname: Gudjónsdóttir
authors.forename: M
authors.initials: M
authors.lastname: Mellai
authors.forename: P
authors.initials: P
authors.lastname: Momigliano-Richiardi
authors.forename: S
authors.initials: S
authors.lastname: Percopo
authors.forename: L
authors.initials: L
authors.lastname: Samuelsson
authors.forename: J
authors.initials: J
authors.lastname: Wahlström
authors.forename: L
authors.initials: L
authors.lastname: Greco
authors.forename: L M
authors.initials: LM
authors.lastname: Sollid
mesh_terms: D000483:Alleles; D002446:Celiac Disease / Q000235:genetics* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics*; D053762:Interleukin-12 Subunit p40; D007422:Intestines / Q000473:pathology; D007558:Italy; D011110:Polymorphism, Genetic; D012537:Scandinavian and Nordic Countries
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; C500879:IL12B protein, human; D053762:Interleukin-12 Subunit p40; D018664:Interleukin-12