Homeostasis of intestinal immune regulation.
Regulatory CD4 T cells with the capacity to inhibit potentially harmful immune responses have been described in various experimental systems. Although the observations are converging towards the naturally activated CD25(+) CD4 T cells as a major population responsible for this protection, there is still considerable disagreement on the molecular and cellular requirements involved to achieve a stable immune homeostasis in vivo.
Annacker
Oliver
O
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Powrie
Fiona
F
D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D005767:Gastrointestinal Diseases / Q000276:immunology* / Q000503:physiopathology; D006706:Homeostasis; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000503:physiopathology; D013379:Substrate Specificity; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology