title: Distribution of azithromycin in plasma and tonsil tissue after repeated oral administration of 10 or 20 milligrams per kilogram in pediatric patients.
abstract: Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribution of azithromycin, suggesting the achievement of enhanced therapeutic concentrations at infective sites of the upper respiratory tract.
authors.affiliation: Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University Hospital of Pisa, Pisa, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Blandizzi
authors.forename: Tecla
authors.initials: T
authors.lastname: Malizia
authors.forename: Giovanna
authors.initials: G
authors.lastname: Batoni
authors.forename: Emilia
authors.initials: E
authors.lastname: Ghelardi
authors.forename: Fabio
authors.initials: F
authors.lastname: Baschiera
authors.forename: Paolo
authors.initials: P
authors.lastname: Bruschini
authors.forename: Sonia
authors.initials: S
authors.lastname: Senesi
authors.forename: Mario
authors.initials: M
authors.lastname: Campa
authors.forename: Mario
authors.initials: M
authors.lastname: Del Tacca
mesh_terms: D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017963:Azithromycin / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D014066:Palatine Tonsil / Q000378:metabolism*; D014069:Tonsillitis / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin