Immunoglobulin E and its regulators.
Novel paradigms are emerging in the field of IgE regulation. Gene-environment interactions are increasingly considered to be major determinants of the type and amplitude of allergen-induced antibody responses. At the molecular level, the mechanistic connection between transcription and switching has been strengthened by the recent discovery that class switch recombination requires activation-induced deaminase, a novel RNA editing enzyme. These findings will be critical for our understanding of the mechanisms that determine immunoglobulin isotype expression during immune responses.
Vercelli
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Respiratory Sciences Center and Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Arizona 85724, USA. donata@resp-sci.arizona.edu
D000818:Animals; D003564:Cytidine Deaminase / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D017578:Immunoglobulin Class Switching; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000235:genetics; D011995:Recombination, Genetic; D014158:Transcription, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D007073:Immunoglobulin E; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase