title: Relationship between ventilatory settings and barotrauma in the acute respiratory distress syndrome.
abstract: OBJECTIVE
  High pressures or volumes may increase the risk of barotrauma in the acute respiratory distress syndrome (ARDS).
  
  
  METHODS
  The first part of the study analyzed data from a prospective trial of two ventilation strategies in 116 patients with ARDS retrospectively, and ventilatory pressures and volumes were compared in patients with or without pneumothorax. The second part consisted of a literature analysis of prospective trials (14 clinical studies, 2270 patients) describing incidence and risk factors for barotrauma in ARDS patients, and mean values of ventilatory parameters were plotted against incidence of barotrauma.
  
  
  RESULTS
  In our clinical trial comparing two tidal volumes, 15 patients (12.3%) developed pneumothorax. There was no significant difference in any pressure or volume between these patients and the rest of the population, including end-inspiratory plateau pressure (P(plat)), driving pressure (P(plat)-PEEP), respiratory rate and compliance. Multiple trauma was more frequent among patients with pneumothorax (27%) than in those without (7%). Duration of mechanical ventilation tended to be longer with pneumothorax. In the literature review, the incidence of barotrauma varied between 0% and 49%, and correlated strongly with P(plat), with a high incidence above 35 cmH(2)O, and with compliance, with a high incidence below 30 ml/cmH(2)O.
  
  
  CONCLUSIONS
  Clinical studies maintaining P(plat) lower than 35 cmH(2)O found no apparent relationship between ventilatory parameters and pneumothorax. Analysis of the literature suggests a correlation when patients receive mechanical ventilation with P(plat) levels exceeding 35 cmH(2)O.
authors.affiliation: Medical Intensive Care Unit, ParisXII Université, INSERM U 492, Henri Mondor Hospital, Créteil, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Boussarsar
authors.forename: Guillaume
authors.initials: G
authors.lastname: Thierry
authors.forename: Samir
authors.initials: S
authors.lastname: Jaber
authors.forename: Françoise
authors.initials: F
authors.lastname: Roudot-Thoraval
authors.forename: François
authors.initials: F
authors.lastname: Lemaire
authors.forename: Laurent
authors.initials: L
authors.lastname: Brochard
mesh_terms: D001469:Barotrauma / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D055370:Lung Injury; D011030:Pneumothorax / Q000453:epidemiology / Q000209:etiology*; D012121:Respiration, Artificial / Q000009:adverse effects*; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D013223:Statistics as Topic