In vitro characterization and in vivo properties of a carbonated apatite bone cement.
This study evaluated the in vivo behavior of an injectable calcium phosphate bone cement implanted in bone defects at the distal end of rabbit femora. After 3 weeks, samples were harvested and processed for undecalcified sectioning. Scanning electron microscopy, transmission electron microscopy, and Fourier transform infrared microspectroscopy showed direct contact of bone and cement without soft tissue interposition, biocompatibility, and bioactivity with osteoconductive properties.
Khairoun
I
I
Laboratoire de Recherche sur les Matériaux d'Intérêt Biologique INSERM 99-03, Faculté de Chirurgie Dentaire, 1 Place Alexis Ricordeau, 44042 Nantes Cedex 01, France. ibrahim.khairoun@sante.univ-nantes.fr
Magne
D
D
Gauthier
O
O
Bouler
J M
JM
Aguado
E
E
Daculsi
G
G
Weiss
P
P
D000818:Animals; D001031:Apatites / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D001843:Bone Cements / Q000737:chemistry*; D001861:Bone Regeneration; D002244:Carbon / Q000737:chemistry*; D005269:Femur / Q000648:ultrastructure; D011817:Rabbits; D017550:Spectroscopy, Fourier Transform Infrared; D013997:Time Factors
D001031:Apatites; D001672:Biocompatible Materials; D001843:Bone Cements; D002244:Carbon