Topical ketorolac tromethamine 0.5% versus diclofenac sodium 0.1% to inhibit miosis during cataract surgery.
OBJECTIVE
To compare the effect of topical ketorolac tromethamine 0.5% solution and topical diclofenac sodium 0.1% solution on the inhibition of surgically induced miosis.


METHODS
Tertiary care teaching hospital in South India.


METHODS
Fifty-one patients were prospectively randomized to receive ketorolac 0.5% or diclofenac 0.1% at 3 intervals preoperatively. Patients with diabetes mellitus, pseudoexfoliation, or local pupil abnormalities were excluded from the study. Mydriatics comprising homatropine 1% plus phenylephrine 10% were instilled in all patients 1 hour before the peribulbar block at 5 intervals. Horizontal pupil diameters were obtained at the beginning of surgery, after capsulotomy, after intraocular lens (IOL) implantation, and at the end of surgery.


RESULTS
The mean horizontal pupil diameter was 7.40 mm at the start of surgery in both groups. The ketorolac group showed a consistent trend toward larger pupil diameters at subsequent surgical intervals. Changes from baseline also indicated more significant inhibition of miosis in the ketorolac group.


CONCLUSIONS
Topical ketorolac was a more effective inhibitor of miosis than topical diclofenac during extracapsular cataract extraction and IOL implantation. It also provided a more stable mydriatic effect throughout surgery.
Srinivasan
Renuka
R
Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Madhavaranga
D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002387:Cataract Extraction / Q000009:adverse effects*; D004008:Diclofenac / Q000008:administration & dosage*; D004311:Double-Blind Method; D006801:Humans; D020910:Ketorolac / Q000008:administration & dosage*; D019654:Lens Implantation, Intraocular; D015877:Miosis / Q000209:etiology / Q000517:prevention & control*; D009184:Mydriatics / Q000008:administration & dosage; D009883:Ophthalmic Solutions; D010865:Pilot Projects; D011446:Prospective Studies; D011680:Pupil / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009184:Mydriatics; D009883:Ophthalmic Solutions; D004008:Diclofenac; D020910:Ketorolac