title: Fluid dynamics of the left ventricular filling in dilated cardiomyopathy.
abstract: Modifications in diastolic function occur in a broad range of cardiovascular diseases and there is an increasing evidence that abnormalities in left ventricular function may contribute significantly to the symptomatology. The flow inside the left ventricle during the diastole is here investigated by numerical solution of the Navier-Stokes equations under the axisymmetric assumption. The equation are written in a body-fitted, moving prolate spheroid, system of coordinates and solved using a fractional step method. The system is forced by a given volume time-law derived from clinical data, and varying the two-degrees-of-freedom ventricle geometry on the basis of a simple model. The solution under healthy conditions is analysed in terms of vorticity dynamics, showing that the flow field is characterised by the presence of a vortex wake; it is attached to the mitral valve during the accelerating phase of the E-wave, and it detaches and translate towards the ventricle apex afterwards. The flow evolution is discussed, results are also reported as an M-mode representation of colour-coded Doppler velocity maps. In the presence of ventricle dilatation the mitral jet extends farther inside the ventricle, propagation velocity decreases, and the fluid stagnates longer at the apex.
authors.affiliation: Dipartimento di Ingegneria Civile, Università di Firenze, Via S. Marta 3, 50139 Firenze, Italy.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Baccani
authors.forename: Federico
authors.initials: F
authors.lastname: Domenichini
authors.forename: Gianni
authors.initials: G
authors.lastname: Pedrizzetti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tonti
mesh_terms: D001783:Blood Flow Velocity; D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000503:physiopathology*; D018056:Hemorheology; D006801:Humans; D008943:Mitral Valve; D008955:Models, Cardiovascular; D012039:Regional Blood Flow; D018487:Ventricular Dysfunction, Left / Q000473:pathology / Q000503:physiopathology*