title: Theoretical and computational models of ion channels.
abstract: Computational studies can make meaningful contributions to our understanding of biological ion channels. A wide variety of methods, at different levels of approximation, can be used. Over the past few years, progress in the experimental determination of three-dimensional structures has given a fresh impetus to the theorists. Noteworthy progress has been made in carefully constructing realistic models of a number of complex biological channels to address important questions about their function.
authors.affiliation: Department of Biochemistry and Structural Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA. benoit.roux@med.cornell.edu
authors.forename: Benoît
authors.initials: B
authors.lastname: Roux
mesh_terms: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D007473:Ion Channels / Q000737:chemistry*; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry; D018272:Porins / Q000737:chemistry; D015221:Potassium Channels / Q000737:chemistry; D011487:Protein Conformation
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D007473:Ion Channels; C086596:MscL protein, E coli; D010455:Peptides; D018272:Porins; D015221:Potassium Channels; C107790:prokaryotic potassium channel