title: Does withholding aspirin for one week reduce the risk of post-sphincterotomy bleeding?
abstract: BACKGROUND
  Complications of endoscopic sphincterotomy are closely related to the endoscopic technique. To date, there have been no studies to indicate that aspirin increases the risk of bleeding after endoscopic sphincterotomy.
  
  
  OBJECTIVE
  To compare the incidence of post-sphincterotomy bleeding in patients with and without prior aspirin therapy.
  
  
  METHODS
  Eight hundred and four patients were recruited into this retrospective study: 124 patients continued to take aspirin until the day of sphincterotomy (Group 1), 116 patients had their aspirin discontinued for 1 week before sphincterotomy (Group 2) and 564 patients had never taken aspirin (Group 3). The primary outcome analysed was the incidence of post-sphincterotomy bleeding.
  
  
  RESULTS
  Sixty-seven patients (8.3%) developed post-sphincterotomy bleeding. The incidences of post-sphincterotomy bleeding in Groups 1, 2 and 3 were 9.7%, 9.5% and 3.9%, respectively. Group 1 showed significantly increased post-sphincterotomy bleeding when compared with Group 3 (P=0.01), and the risk was also significantly increased when Group 2 was compared with Group 3 (P=0.01). However, there was no significant difference in post-sphincterotomy bleeding between Groups 1 and 2 (P=0.96).
  
  
  CONCLUSIONS
  Aspirin therapy increased the risk of post-sphincterotomy bleeding. Withholding aspirin for 1 week before endoscopic sphincterotomy did not seem to decrease the risk of post-sphincterotomy bleeding.
authors.affiliation: Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
authors.forename: C-K
authors.initials: CK
authors.lastname: Hui
authors.forename: K-C
authors.initials: KC
authors.lastname: Lai
authors.forename: M-F
authors.initials: MF
authors.lastname: Yuen
authors.forename: W-M
authors.initials: WM
authors.lastname: Wong
authors.forename: S-K
authors.initials: SK
authors.lastname: Lam
authors.forename: C-L
authors.initials: CL
authors.lastname: Lai
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011183:Postoperative Complications; D019106:Postoperative Hemorrhage / Q000139:chemically induced* / Q000517:prevention & control; D012189:Retrospective Studies; D012307:Risk Factors; D016717:Sphincterotomy, Endoscopic
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin