[Do preterm infants differ from healthy newborns by endothelin para/endocrine function?].
We measured plasma concentration of endothelin-1 (ET-1), nitric oxide metabolites (NOx) and von Willebrand factor (vWF) in maternal and umbilical cord blood in 11 spontaneous (SN), 11 elective cesarean section (CC) and 13 preterm deliveries. Plasma concentrations of ET-1 in umbilical cord blood of preterm infants and systemic blood withdrawn 4 days after birth was higher then in respective healthy infants delivered by natural forces or elective cesarean section. Positive correlation were found between ET-1 and NOx (p < 0.05) and between ET-1 and vWF (p < 0.05) in maternal blood with preterm delivery. In umbilical cord of preterm infants a negative correlation between ET-1 and Apgar score was noticed. Higher concentrations of ET-1, NOx and vWF found in umbilical cord blood of preterm infants as compared with respective values assessed in healthy infants delivered per vaginam or by cesarean section respectively seem to be induced by hypoxia.
Baumert
Małgorzata
M
Klinika Neonatologii III Katedry Połoznictwa i Ginekologii Sl. AM, Katowicach.
Wiecek
Andrzej
A
Kokot
Franciszek
F
Sikora
Jerzy
J
Osuch-Jaczewska
Rozalia
R
D002585:Cesarean Section; D036861:Delivery, Obstetric; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D009569:Nitric Oxide / Q000097:blood*; D011247:Pregnancy; D014841:von Willebrand Factor / Q000378:metabolism*
D019332:Endothelin-1; D014841:von Willebrand Factor; D009569:Nitric Oxide