title: Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group.
abstract: A large scale multicenter study of cerebrospinal fluid (CSF) tau levels was conducted to determine the cut-off value, sensitivity and specificity for clinical usage as a biomarker of Alzheimer's disease (AD). Its use for early and differential diagnosis and the factors that increase CSF tau levels were also examined. CSF samples from a total of 1,031 subjects including 366 patients with AD, 168 patients with non-Alzheimer type dementia (NA), 316 patients with non-dementia neurological diseases (ND) and 181 normal controls (NC) were measured using ELISA for tau. The cut-off value of tau, 375 pg/ml, showed 59.1% sensitivity and 89.5% specificity for diagnosis of AD compared with the other groups. The tau levels were increased from the early to late stages of AD. Elevation of CSF tau in the non-tauopathy and tauopathy dementia groups, chronic and acute damage to the cerebrum, and meningeal disturbance were other factors that required attention for clinical practice. Measurement of CSF tau was useful as a biomarker for early and differential diagnosis of AD.
authors.affiliation: Department of Neurology, Division of Neuroscience/Biophysical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. mshoji@cc.okayama-u.ac.jp
authors.forename: Mikio
authors.initials: M
authors.lastname: Shoji
authors.forename: Etsuro
authors.initials: E
authors.lastname: Matsubara
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Murakami
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Manabe
authors.forename: Koji
authors.initials: K
authors.lastname: Abe
authors.forename: Mitsuyasu
authors.initials: M
authors.lastname: Kanai
authors.forename: Masaki
authors.initials: M
authors.lastname: Ikeda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Tomidokoro
authors.forename: Masami
authors.initials: M
authors.lastname: Shizuka
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Watanabe
authors.forename: Masakuni
authors.initials: M
authors.lastname: Amari
authors.forename: Koji
authors.initials: K
authors.lastname: Ishiguro
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kawarabayashi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Harigaya
authors.forename: Koichi
authors.initials: K
authors.lastname: Okamoto
authors.forename: Tsuyosi
authors.initials: T
authors.lastname: Nishimura
authors.forename: Yu
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
authors.forename: Katsuya
authors.initials: K
authors.lastname: Urakami
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Adachi
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakashima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai
authors.forename: Hidetada
authors.initials: H
authors.lastname: Sasaki
authors.forename: Kazutomi
authors.initials: K
authors.lastname: Kanemaru
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamanouchi
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Ichise
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Tanaka
authors.forename: Makoto
authors.initials: M
authors.lastname: Hamamoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Matsubayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Toji
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Nakamura
authors.forename: Shunsaku
authors.initials: S
authors.lastname: Hirai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000134:cerebrospinal fluid / Q000378:metabolism; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000453:epidemiology; D000704:Analysis of Variance; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002648:Child; D003704:Dementia / Q000134:cerebrospinal fluid* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D015415:Biomarkers; D016875:tau Proteins