Unexpected response of a pulmonary blastoma on radiotherapy: a case report and review of the literature.
Pulmonary blastoma (PB) is a rare malignant tumor of the lung. Treatment is primarily surgical, although, combination chemotherapy has been reported to result in objective responses in inoperable tumors or after incomplete resections. To our knowledge, this is the first report of a very radiosensitive PB, which showed major tumor reduction after several fractions of radiotherapy without further tumor regression after additional chemotherapy with cisplatin and etoposide. The literature on the treatment of PB is reviewed.
Surmont
Veerle F
VF
Department of Pulmonology, Respiratory Oncology Unit, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. veerle.surmont@uz.kuleuven.ac.be
van Klaveren
Rob J
RJ
Nowak
Peter J C M
PJ
Zondervan
Pieter E
PE
Hoogsteden
Henk C
HC
van Meerbeeck
Jan P
JP
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D004847:Epithelial Cells / Q000473:pathology; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D018202:Pulmonary Blastoma / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D017154:Stromal Cells / Q000473:pathology; D014057:Tomography, X-Ray Computed
D005047:Etoposide; D002945:Cisplatin