Kinase regulation: competing phosphatases in JAK dephosphorylation.
The Janus kinases (JAKs) are essential for cytokine receptor signalling and their dephosphorylation represents a potent inhibitory mechanism. A new paper highlights the T-cell tyrosine phosphatase as an important JAK inhibitor.
Alexander
Denis R
DR
Laboratory of Lymphocyte Signalling and Development, Molecular Immunology Programme, The Babraham Institute, CB2 4AT, Cambridge, UK.
D000818:Animals; D001667:Binding, Competitive; D002453:Cell Cycle; D006801:Humans; D053613:Janus Kinase 1; D010766:Phosphorylation; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018121:Receptors, Cytokine / Q000378:metabolism; D015398:Signal Transduction; D013379:Substrate Specificity; D013601:T-Lymphocytes / Q000166:cytology / Q000201:enzymology* / Q000378:metabolism
D018121:Receptors, Cytokine; D011505:Protein-Tyrosine Kinases; C507904:JAK1 protein, human; D053613:Janus Kinase 1; D017027:Protein Tyrosine Phosphatases