title: Preparation and crystal structure of a trihydrate of paracetamol.
abstract: This work reports the preparation and crystal structure of a trihydrate of paracetamol. Crystals were grown by slow cooling of an aqueous solution of paracetamol to 0 degrees C. Single-crystal X-ray diffraction shows that the trihydrate crystallizes in the orthorhombic crystal system, space group Pbca, Z = 8, a = 7.3324(16), b = 12.590(3), c = 22.636(6) A, V = 2089.7(9) A(3). The crystals of the trihydrate dehydrate rapidly at 20 degrees C to give anhydrous paracetamol as its monoclinic form.
authors.affiliation: Department of Physics and Astronomy, The University of Edinburgh, James Clerk Maxwell Building, King's Buildings, Mayfield Road, Edinburgh EH9 3JZ, Scotland, UK.
authors.forename: Pamela A
authors.initials: PA
authors.lastname: McGregor
authors.forename: David R
authors.initials: DR
authors.lastname: Allan
authors.forename: Simon
authors.initials: S
authors.lastname: Parsons
authors.forename: Colin R
authors.initials: CR
authors.lastname: Pulham
mesh_terms: D000082:Acetaminophen / Q000138:chemical synthesis* / Q000737:chemistry*; D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen