title: Understanding sepsis: from SIRS to septic shock.
abstract: Sepsis remains the leading cause of death in non-coronary ICU patients, despite improvements in supportive treatment modalities such as antimicrobial drugs and ventilation therapy. Further, the incidence of sepsis is projected to increase in years to come, related to factors including a rise in immunosuppressed patient populations and more widespread use of invasive lines and procedures. In this article, the authors seek to advance nurses' understanding of sepsis by reviewing the SIRS to septic shock paradigm and using a case study to illustrate how a patient progressed along the continuum. The role of the critical care nurse is an important aspect of the care of these patients. Early identification of patients at risk for, or who are developing, sepsis is crucial in order to improve patient outcomes.
authors.affiliation: Mount Sinai Hospital, ICU, Toronto, Ontario.
authors.forename: Patricia
authors.initials: P
authors.lastname: Hynes-Gay
authors.forename: Patti
authors.initials: P
authors.lastname: Lalla
authors.forename: Maria
authors.initials: M
authors.lastname: Leo
authors.forename: Audrey
authors.initials: A
authors.lastname: Merrill-Bell
authors.forename: Marjorie
authors.initials: M
authors.lastname: Nicholson
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Villaruel
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000175:diagnosis* / Q000503:physiopathology*; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis* / Q000503:physiopathology*