title: [Changes of antioxidative capacity and endothelial function before and after treatment among patients with high altitude pulmonary edema].
abstract: OBJECTIVE
  To investigate the changes of antioxidative capacity and endothelial function among patients with high altitude pulmonary edema (HAPE).
  
  
  METHODS
  The serum levels of SOD, MDA, GSH, NO, NOS and ET-1 were measured before and after treatment among 34 cases of patients with HAPE, and 20 local healthy volunteers served as control.
  
  
  RESULTS
  The serum levels of SOD, GSH, NO and NOS were lower in patient-group before treatment than after treatment and those in control-group significantly (P < 0.01), while the concentration of MDA and ET-1 were higher in patient-group before treatment than after treatment and those in the control-group significantly (P < 0.01). The serum levels of SOD, MDA, GSH, NO, NOS and ET-1 were not different between patient-group after treatment and the control-group (P > 0.05).
  
  
  CONCLUSIONS
  The results indicated that changes of SOD, MDA, GSH, NO, NOS and ET-1 may participate in the course of HAPE.
authors.affiliation: Department of Internal Medicine, The 41st Hospital of PLA, Shannan, 856100, China.
authors.forename: Zhongming
authors.initials: Z
authors.lastname: Fu
authors.forename: Ping
authors.initials: P
authors.lastname: Jiang
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Ren
authors.forename: Shunzhou
authors.initials: S
authors.lastname: Peng
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Xianyang
authors.initials: X
authors.lastname: Luo
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Zou
authors.forename: Man
authors.initials: M
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000532:Altitude Sickness / Q000097:blood* / Q000473:pathology; D000975:Antioxidants / Q000378:metabolism*; D019332:Endothelin-1 / Q000097:blood; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D019001:Nitric Oxide Synthase / Q000097:blood; D011654:Pulmonary Edema / Q000097:blood* / Q000473:pathology; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D019332:Endothelin-1; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D005978:Glutathione