title: Aspects of haemophilia prophylaxis in Sweden.
abstract: Prophylactic treatment of haemophilia has been gaining acceptance as the optimal therapeutic option in an increasing number of haemophilia centres in the developed world in recent years. This paper focus on three aspects of prophylactic therapy: when to start treatment, venous access and the dose/dose interval. Evidence is in favour of prophylactic treatment to be started at an early age using either a peripheral vein with 1-2 injections per week and a successive increase in the frequency depending on the child and the veins, or, using a Port-A-Cath which allows a better prophylactic coverage by infusions preferably every second day in haemophilia A and every third day in haemophilia B.
authors.affiliation: Department of Paediatrics, Lund University, University Hospital, Malmö, Sweden. Rolf.Ljung@pediatrik.mas.lu.se
authors.forename: R C R
authors.initials: RC
authors.lastname: Ljung
mesh_terms: D000293:Adolescent; D000328:Adult; D002408:Catheters, Indwelling / Q000706:statistics & numerical data; D002648:Child; D004334:Drug Administration Schedule; D005164:Factor IX / Q000008:administration & dosage*; D005169:Factor VIII / Q000008:administration & dosage*; D006395:Hemarthrosis / Q000517:prevention & control; D006467:Hemophilia A / Q000517:prevention & control*; D002836:Hemophilia B / Q000517:prevention & control*; D006801:Humans; D007275:Injections, Intravenous; D013548:Sweden / Q000453:epidemiology
chemical_list: D005169:Factor VIII; D005164:Factor IX