Anti-immunoglobulin E for the treatment of allergic disease.
IgE plays a central role in allergic disease and participates in the associated inflammatory process. A mainstay of treatment of allergic disease, including asthma, is allergen avoidance and treatment of symptoms. Presently, the most effective treatments for allergic diseases are directed towards a regulation of the inflammatory process with corticosteroids. An exciting new approach is anti-IgE (rhuMAb-E25), which would regulate the allergic process at the level of IgE. The following information will review recent experiences with anti-IgE and discuss the conditions in which this approach may be effective.
Busse
W
W
Department of Medicine, Allergy and Clinical Immunology Section, University of Wisconsin, Madison, Wisconsin 53792, USA. wwb@medicine.wisc.edu
Neaville
W
W
D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D001249:Asthma / Q000628:therapy*; D006801:Humans; D012221:Rhinitis, Allergic, Perennial / Q000628:therapy*; D006255:Rhinitis, Allergic, Seasonal / Q000628:therapy*
D000888:Antibodies, Anti-Idiotypic; C026408:anti-IgE antibodies