title: Long-term results of ileocecal continent urinary diversion in patients treated with and without previous pelvic irradiation.
abstract: OBJECTIVE
  Patients who receive pelvic irradiation may require urinary diversion to manage complications resulting from progressive malignancy or radiotherapy. The choice of urinary diversion is an important issue and remains controversial. We characterized the long-term outcome of urinary diversion with a continent ileocecal reservoir in patients who received pelvic irradiation versus those who underwent urinary diversion without previous irradiation.
  
  
  METHODS
  Continent urinary diversion with an ileocecal reservoir (Mainz pouch 1) was performed in 36 irradiated patients in a 9-year period. Morbidity, mortality, the reoperative rate and parameters associated with the surgical procedure were determined at a median followup of 57 months. Results were compared with those in 385 nonirradiated patients who received the same type of continent diversion after cystectomy for bladder cancer.
  
  
  RESULTS
  Irradiated patients had a significantly higher rate of serious complications after ileocecal urinary diversion than nonirradiated controls. Continence mechanism failure occurred in 25% of patients in the irradiated group and 5.7% in nonirradiated patients, stomal complications were noted in 38.8% and 10.6%, and ureteral complications developed in 22.2% and 6.5%, respectively.
  
  
  CONCLUSIONS
  In patients who have received pelvic radiotherapy, ileocecal Mainz pouch 1 continent urinary diversion is associated with a high rate of serious complications and should be avoided.
authors.affiliation: Department of Urology, University of Mainz School of Medicine, Mainz, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Wammack
authors.forename: Christine
authors.initials: C
authors.lastname: Wricke
authors.forename: Rudolf
authors.initials: R
authors.lastname: Hohenfellner
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010388:Pelvis / Q000528:radiation effects*; D011183:Postoperative Complications / Q000209:etiology*; D011832:Radiation Injuries / Q000209:etiology*; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D016476:Urinary Reservoirs, Continent