The tau H1 haplotype is associated with Parkinson's disease in the Norwegian population.
We investigated the association of Parkinson's disease (PD) with tau gene H1 haplotypes in the Norwegian population. In a sample of 96 unrelated PD cases and 68 control subjects, we observed an increased risk of PD for persons with the tau H1 haplotype (odds ratio=5.52; 95% confidence interval: 2.64-11.10; P=2.17x10(-6)). Findings provide evidence that tau participates in the PD pathogenic process and demonstrate the value of isolated populations in mapping complex traits.
Farrer
Matt
M
Laboratory of Familial Movement Disorders, Mayo Clinic, Jacksonville, FL, USA.
Skipper
Lisa
L
Berg
Marianne
M
Bisceglio
Gina
G
Hanson
Melissa
M
Hardy
John
J
Adam
Amanda
A
Gwinn-Hardy
Katrina
K
Aasly
Jan
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016001:Confidence Intervals; D005260:Female; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D016017:Odds Ratio; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D016875:tau Proteins / Q000235:genetics*
D016875:tau Proteins