Helicobacter pylori vacuolating cytotoxin, VacA.
Helicobacter pylori is the leading bacterial cause of food-borne illness worldwide and plays a major role in the development of chronic gastritis, peptic ulcer, and gastric cancer. Strains isolated from patients contain the cagA gene (cytotoxin-associated gene A) and produce the vacuolating cytotoxin, VacA. Recent molecular and cellular studies of VacA action have begun to unravel its structure and the details of the mechanism of gastric injury caused by H. pylori infection.
Hirayama
Toshiya
T
Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.
Wada
Akihiro
A
Yahiro
Kinnosuke
K
Kimura
Miyuki
M
Kimura
Takahiro
T
D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D001427:Bacterial Toxins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D016923:Cell Death; D003603:Cytotoxins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D016481:Helicobacter Infections / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D010437:Peptic Ulcer / Q000382:microbiology / Q000473:pathology; D014617:Vacuoles / Q000382:microbiology
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D003603:Cytotoxins; C074689:VacA protein, Helicobacter pylori