Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap.
TCR stimulation induces integrin-mediated adhesion, facilitating stabilization of conjugates between T cells and antigen-presenting cells and thereby contributing to T cell activation. Integrin activation has been shown to require cytoskeletal reorganization; however, the molecular mechanisms mediating communication between the TCR and integrins remain unclear. Recently the adapter protein ADAP/Fyb/Slap has been shown to couple TCR stimulation to integrin activation by mediating increased integrin avidity. ADAP may also play a role in transduction of external signals by integrins. Like other adapters, ADAP is a multifunctional protein and interacts with molecules such as Fyn, Slp-76, Ena/VASP proteins, Vav1, WASP and the Arp2/3 complex.
Griffiths
Emily K
EK
Amgen, Department of Medical Biophysics and Immunology, University of Toronto, 620 University Avenue, Ontario M5G 2C1, Toronto, Canada.
Penninger
Josef M
JM
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D015550:Cell Degranulation / Q000502:physiology; D004268:DNA-Binding Proteins; D006801:Humans; D016023:Integrins / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology*; D011506:Proteins / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D051316:Wiskott-Aldrich Syndrome Protein
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; C092744:ENA-VASP proteins; C106957:FYB1 protein, human; D016023:Integrins; D010750:Phosphoproteins; D011506:Proteins; D011948:Receptors, Antigen, T-Cell; C495767:WAS protein, human; D051316:Wiskott-Aldrich Syndrome Protein