title: Clathriol, a novel polyoxygenated 14beta steroid isolated from the New Zealand marine sponge Clathria lissosclera.
abstract: Clathriol (1), a highly oxygenated steroid with the unusual 14beta configuration, was isolated from the New Zealand marine sponge Clathria lissosclera. The structure was elucidated from a combination of NMR and mass spectroscopy. Clathriol showed in vitro antiinflammatory activity against human neutrophyl and rat mast cells.
authors.affiliation: School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Keyzers
authors.forename: Peter T
authors.initials: PT
authors.lastname: Northcote
authors.forename: Vicky
authors.initials: V
authors.lastname: Webb
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D006636:Histamine Release / Q000187:drug effects; D008407:Mast Cells / Q000187:drug effects; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D051381:Rats; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D013256:Steroids; C457247:clathriol