Benzimidazole-4,7-diones as inhibitors of protozoal (Toxoplasma gondii) purine nucleoside phosphorylase.
Benzimidazole-4,7-diones derivatives substituted at 1- and/or 2-position have been synthetized and tested as inhibitors of purine nucleoside phosphorylase (PNP), isolated from two strains of Toxoplasma gondii (RH and ME 49). They were identified as inhibitors of both enzymes.
Alvarez
Frédéric
F
Laboratoire de Chimie Organique (EA 635), Faculté de Pharmacie, Université Lyon I, 8, Avenue Rockefeller, 69373 Lyon Cedex 08, France.
Ghérardi
Arnaud
A
Nebois
Pascal
P
Sarciron
Marie Elizabeth
ME
Pétavy
Anne Françoise
AF
Walchshofer
Nadia
N
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014122:Toxoplasma / Q000201:enzymology*
D000981:Antiprotozoal Agents; D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D011683:Purine-Nucleoside Phosphorylase