title: Effect of vitamin A supplementation on measles-specific antibody levels in Guinea-Bissau.
abstract: We have previously reported that vitamin A supplementation with measles vaccine at age 9 months increases measles-specific antibody concentrations in children at age 18 months compared with placebo. We examined these children when they reached age 6-8 years. Fewer vitamin A-supplemented children had non-protective antibody concentrations (p=0.0095); among children with protective antibody levels, vitamin A-supplemented children tended to have higher geometric mean antibody titres (p=0.09). Thus, simultaneous administration of vitamin A and measles vaccine at age 9 months had a long-term effect on measles-specific antibody levels and may contribute to improved measles control in less-developed countries.
authors.forename: Christine Stabell
authors.initials: CS
authors.lastname: Benn
authors.forename: Aliu
authors.initials: A
authors.lastname: Balde
authors.forename: Elisha
authors.initials: E
authors.lastname: George
authors.forename: Michael
authors.initials: M
authors.lastname: Kidd
authors.forename: Hilton
authors.initials: H
authors.lastname: Whittle
authors.forename: Ida Marie
authors.initials: IM
authors.lastname: Lisse
authors.forename: Peter
authors.initials: P
authors.lastname: Aaby
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D002986:Clinical Trials as Topic; D005260:Female; D005500:Follow-Up Studies; D006169:Guinea-Bissau; D006801:Humans; D007223:Infant; D008297:Male; D008457:Measles / Q000276:immunology* / Q000401:mortality / Q000517:prevention & control; D008458:Measles Vaccine; D014801:Vitamin A / Q000627:therapeutic use*
chemical_list: D000914:Antibodies, Viral; D008458:Measles Vaccine; D014801:Vitamin A