Histological examination of the thyroid after experimental administration of Metizol.
The investigations were carried out on thyroids of white Wistar rats which were given Metizol for 3 days, 3 and 6 weeks at the dose of 1 mg/kg of b.m. for 24 hrs. The samples were stained with hematoxylin and eosin and by the PAS method. The following changes were observed: 1. Three-day administration of Metizol resulted in the decrease in the quantity of colloid; the secretory epithelium became uniform--i.e. cubic; the quantity of the interfollicular tissue increased. 2. Three-week administration of Metizol resulted in appearing of colloid stained differently than in the control group; secretory epithelium cells were of different height (cubic and cylindrical), a considerate congestion of the gland was visible, the quantity of the interfollicular tissue increased. 3. After 6 weeks of Metizol administration the morphological picture of the thyroid became similar to that of the control group.
Cichacz-Kwiatkowska
B
B
Department of Institute of Histology and Embryology, Medical University of Lublin.
Lis-Sochocka
M
M
Zakrzewski
P
P
Milewska
J
J
Czerny
K
K
D000818:Animals; D013956:Antithyroid Agents / Q000633:toxicity*; D003102:Colloids / Q000032:analysis; D004334:Drug Administration Schedule; D004848:Epithelium / Q000473:pathology; D008297:Male; D008713:Methimazole / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*
D013956:Antithyroid Agents; D003102:Colloids; D008713:Methimazole