Base-pairing systems related to TNA: alpha-threofuranosyl oligonucleotides containing phosphoramidate linkages.
(3'NH)- and (2'NH)-TNA, two isomeric phosphoramidate analogues of TNA (alpha-threofuranosyl-(3'-->2') oligonucleotides), are shown to be efficient Watson-Crick base-pairing systems and to undergo intersystem cross-pairing with TNA, RNA, and DNA. [reaction: see text]
Wu
Xiaolin
X
The Skaggs Institute for Chemical Biology at the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Guntha
Sreenivasulu
S
Ferencic
Mathias
M
Krishnamurthy
Ramanarayanan
R
Eschenmoser
Albert
A
D000577:Amides / Q000737:chemistry; D020029:Base Pairing; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D007202:Indicators and Reagents; D009841:Oligonucleotides / Q000737:chemistry; D010756:Phosphoric Acids / Q000737:chemistry; D012313:RNA / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013056:Spectrophotometry, Ultraviolet
D000577:Amides; D005663:Furans; D007202:Indicators and Reagents; D009841:Oligonucleotides; D010756:Phosphoric Acids; D012313:RNA; D004247:DNA; C011067:phosphoramidic acid