Aryl-aryl coupling reaction using a novel and highly active palladium reagent prepared from Pd(OAc)2, 1,3-bis[diphenylphosphino]propane (DPPP), and Bu3P.
A palladium-assisted coupling reaction of aryl triflate with arene was investigated, and a novel Pd reagent prepared from equimolar Pd(OAc)2, 1,3-Bis[diphenylphosphino]propane (DPPP), and Bu3P was developed. This method is useful for intramolecular biaryl coupling reactions, not only between aryl triflate and arene (triflate-amide), but also between aryl halide and arene (halo-amide).
Harayama
Takashi
T
Faculty of Pharmaceutical Sciences, Okayama University, Japan. harayama@pharm.okayama-u.ac.jp
Akiyama
Toshihiko
T
Nakano
Yuichiro
Y
Nishioka
Hiromi
H
Abe
Hitoshi
H
Takeuchi
Yasuo
Y
D003500:Cyclization; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D011407:Propane / Q000031:analogs & derivatives / Q000737:chemistry*
D006841:Hydrocarbons, Aromatic; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D010720:Phosphines; C043255:tri-n-butylphosphine; C467590:1,3-bis(diphenylphosphino)propane; D010165:Palladium; D011407:Propane