title: [Testosterone induction of metallothionein in accessory genital organs of male domestic cats].
abstract: Orchidectomy of cats resulted in a decrease of metallothionein (MT) in the dorsolateral and ventral lobes of the prostate and in the urethral gland to 21.2% (P<0.01), 88.4% (P>0.05) and 18.5% (P<0.01) of those of intact domestic cats respectively. MT content in the dorsolateral lobe and urethral gland was not restored in orchidectomized cats injected with sesame oil. After injection of a single subcutaneous dose of 10 microg/kg bw of testosterone (T) for 3 d in succession, the MT contents in the two glands were restored respectively to 69.3% and 59.4% of the intact cats. With an increase of T dose to 5, 10, 15, 20, 25 microg/kg bw, plasma T and MT contents in the dorsolateral lobe of prostate and urethral gland increased accordingly. Plasma T concentrations were positively correlated with MT contents in the dorsolateral lobe of prostate and urethral glands (P<0.01). Thus biosynthesis of MT in the dorsolateral lobe of prostate or in urethral gland could be induced by a stimulatory dose of T of 20 microg/kg bw.
authors.affiliation: Department of Biology, Shandong Teachers   University, Jinan  250014.
authors.forename: D C
authors.initials: DC
authors.lastname: Liu
authors.forename: Y J
authors.initials: YJ
authors.lastname: Yuan
mesh_terms: D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D008297:Male; D008668:Metallothionein / Q000096:biosynthesis*; D009919:Orchiectomy; D011467:Prostate / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology*; D014521:Urethra / Q000378:metabolism*
chemical_list: D013739:Testosterone; D008668:Metallothionein