Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Intravenous bolus or infusion of naloxone in opioid overdose.
A short cut review was carried out to establish whether intravenous boluses of naloxone are better than intravenous infusion in opioid overdose. Altogether 188 papers were found using the reported search, of which one presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of this best paper is tabulated. A clinical bottom line is stated.
Clarke
Simon
S
Dargan
Paul
P
D000328:Adult; D000931:Antidotes / Q000008:administration & dosage*; D062787:Drug Overdose / Q000628:therapy; D019317:Evidence-Based Medicine; D006556:Heroin Dependence / Q000628:therapy; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008691:Methadone / Q000506:poisoning*; D009270:Naloxone / Q000008:administration & dosage*; D009292:Narcotic Antagonists / Q000008:administration & dosage*; D009293:Opioid-Related Disorders / Q000628:therapy*
D000931:Antidotes; D009292:Narcotic Antagonists; D009270:Naloxone; D008691:Methadone