Clinical implications of urokinase and tissue type plasminogen activators and their inhibitor (PAI-1) in breast cancer tissue.
Cytosol of primary breast cancers from 217 women of predominantly Arab ethnicity were assayed for uPA, tPA, PAI-1 and a subset for ER, PR and pS2. Serum levels of CEA and CA153 were determined during follow-up. Only tPA correlated to nodal status and tumour grade, and PAI-1 to clinical stage. PAI-1 was related to uPA and both were inversely correlated with PR and pS2 (PAI-1 also to ER). Conversely tPA was directly correlated with ER, PR and pS2. Women with high tumour uPA and PAI-1, but not tPA, had shorter overall, and relapse-free, survival. Only nodal status and clinical stage were independent predictors in multivariate analysis. However, uPA and PAI-1 were more prognostically informative than ER or PR and their usefulness may extend to delineation of patients likely to respond to adjuvant therapy.
Luqmani
Y A
YA
Kuwait University, Faculty of Pharmacy, Safat 13110, Kuwait. yunus@hsc.kuniv.edu.kw
Temmim
L
L
Parkar
A H
AH
Mathew
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000378:metabolism*; D002272:Carcinoembryonic Antigen / Q000097:blood; D003600:Cytosol / Q000378:metabolism; D018572:Disease-Free Survival; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000096:biosynthesis*; D011379:Prognosis; D014176:Protein Biosynthesis; D011506:Proteins; D011960:Receptors, Estrogen / Q000096:biosynthesis; D011980:Receptors, Progesterone / Q000096:biosynthesis; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000096:biosynthesis*; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins; D014568:Urokinase-Type Plasminogen Activator / Q000096:biosynthesis*
D002272:Carcinoembryonic Antigen; D018396:Mucin-1; D017395:Plasminogen Activator Inhibitor 1; D011506:Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator