p35 protein as a prognostic factor of squamous cell carcinoma of the oesophagus.
Communications show that in squamous cell carcinoma of the oesophagus one can often observe overexpression of p53 protein. Wild type p53 protein suppresses cells' growth, and mutated p53 acts as onkogene. Gene p53 mutations usually lead to stabilization and accumulation of p53 protein, and, as a result they become detectable by immunochemical methods. Overexpression of p53 has been observed in 28 (46.7%) out of 60 collected specimens. It has no connection with sex, age, histological differentiation, category (pT) of tumour, infiltration (pN) of lymph nodes and extent of metastases (pMlym+). p53 protein expression has no correlation with survival predictability.
Dabrowski
A
A
Department of General Surgery, Medical University of Lublin.
Brajerski
G
G
Wallner
G
G
Ziemiakowicz
R
R
D001425:Bacterial Outer Membrane Proteins / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000401:mortality / Q000556:secondary; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000032:analysis*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
D001425:Bacterial Outer Membrane Proteins; D014408:Biomarkers, Tumor; D008074:Lipoproteins