title: Oesophageal motor and sensitivity abnormalities in non-obstructive dysphagia.
abstract: OBJECTIVE
  To evaluate oesophageal sensitivity to balloon distension in patients with non-obstructive dysphagia (NOD), and to determine its relationship with the motility pattern in response to food ingestion.
  
  
  METHODS
  Twenty-one healthy volunteers and 19 consecutive patients complaining of NOD with normal standard manometry were included. An oesophageal sensitivity test was carried out before the manometry study with liquid and solid swallows.
  
  
  RESULTS
  The median threshold to distension was 9 ml in control subjects and 5 ml in patients (P < 0.002). Dysphagia or odynophagia were reproduced in 15/19 (78.9%) patients during manometry with solid swallows only. The percentage of swallows with abnormal motility patterns was higher in patients than control subjects (P < 0.001). Compared with control values, sensitivity abnormality was defined by a distension threshold of < 6 ml. Motor abnormality was defined by > 19% of swallows occurring with one or more abnormal motor profiles. A total of 8/19 (42%) patients presented with the association of an abnormal sensitivity threshold and an abnormal motor pattern; 5/19 (26%) presented with isolated motor abnormalities; 4/19 (21%) patients presented with isolated abnormal sensitivity thresholds; and 2/19 (11%) patients presented without any abnormality.
  
  
  CONCLUSIONS
  Manometry with solid swallows and oesophageal balloon distension are useful in characterizing NOD.
authors.affiliation: Département d'Hépato-Gastroentérologie, C.H.U. de Grenoble, Grenoble, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Bohn
authors.forename: Bruno
authors.initials: B
authors.lastname: Bonaz
authors.forename: Nasser
authors.initials: N
authors.lastname: Gueddah
authors.forename: Alain
authors.initials: A
authors.lastname: Rolachon
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Papillon
authors.forename: Richard
authors.initials: R
authors.lastname: Bost
authors.forename: Jacques
authors.initials: J
authors.lastname: Fournet
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002404:Catheterization; D003679:Deglutition / Q000502:physiology; D003680:Deglutition Disorders / Q000503:physiopathology*; D015154:Esophageal Motility Disorders / Q000503:physiopathology*; D004943:Esophagogastric Junction / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D008365:Manometry; D010528:Peristalsis; D011446:Prospective Studies