T helper type 1 cells in asthma: friend or foe?
A large body of research supports a pathogenic role for T helper 2 cells in asthma, although T helper 1 cell-type responses may also contribute. Using the principle of T helper cell cross-regulation, investigators have attempted to regulate the pathological effects of T helper 2 cells using regimens that may promote T helper 1 cell-type inflammation. In this review, we propose that the use of factors that promote T helper 1 cell differentiation and activation to treat asthma may be counterproductive, and that alternate regulatory approaches should be explored.
Stephens
Robin
R
Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294, USA.
Eisenbarth
Stephanie C
SC
Chaplin
David D
DD
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology / Q000378:metabolism; D001249:Asthma / Q000209:etiology* / Q000276:immunology; D016207:Cytokines / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology; D015536:Down-Regulation; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000276:immunology; D007378:Interleukins / Q000627:therapeutic use; D008213:Lymphocyte Activation; D051379:Mice; D008954:Models, Biological; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism
D000942:Antigens, Bacterial; D016207:Cytokines; D007378:Interleukins