[Myocardial preconditioning and its practical significance].
The authors review the history and physiological basis of myocardial preconditioning including its receptors, signalization and effectors. The classical and delayed (second window) type of preconditioning and relations of the latter to heat shock proteins are discussed. Preconditioning as a form of endogenous adaptation effectively reduces the degree of myocardial injury during a subsequent ischaemia in experimental models and in human as well. Intentional triggering or augmentation of the condition may become a new therapeutic tool in the treatment of ischaemic diseases. Utilizing the advantages of endogen adaptation, the optimal drug or procedure to be applied in the routine clinical practice will come out in the future considering its efficacy and the safety and convenience of the patient.
Hejjel
László
L
Altalános Orvostudományi Kar, Szívgyógyászati Klinika, Pécsi Tudományegyetem, Pécs.
Röth
Erzsébet
E
D000818:Animals; D002450:Cell Communication; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods; D017202:Myocardial Ischemia / Q000378:metabolism / Q000517:prevention & control