title: Anti-thyroid drug methimazole: X-ray characterization of two novel ionic disulfides obtained from its chemical oxidation by I(2).
abstract: Interaction of methimazole (MMI, 1-methyl-imidazole-2-thione) with I2 in solvents having different polarity gives two new stable compounds containing a dication disulfide and a monocation disulfide arranged in dimers, respectively. These two species could represent effective intermediates in the reaction of MMI with an active iodine species in the thyroid gland and therefore shed more light on the mechanism of action of MMI as an antithyroid drug.
authors.affiliation: Dipartimento di Chimica Inorganica ed Analitica, S.S. 554 bivio per Sestu, I-09042 Monserrato (CA), Italy.
authors.forename: M Carla
authors.initials: MC
authors.lastname: Aragoni
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Arca
authors.forename: Francesco
authors.initials: F
authors.lastname: Demartin
authors.forename: Francesco A
authors.initials: FA
authors.lastname: Devillanova
authors.forename: Alessandra
authors.initials: A
authors.lastname: Garau
authors.forename: Francesco
authors.initials: F
authors.lastname: Isaia
authors.forename: Vito
authors.initials: V
authors.lastname: Lippolis
authors.forename: Gaetano
authors.initials: G
authors.lastname: Verani
mesh_terms: D013956:Antithyroid Agents / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007455:Iodine / Q000737:chemistry*; D008713:Methimazole / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D013956:Antithyroid Agents; D008713:Methimazole; D007455:Iodine