Plasma endothelin in patients with acute aortic disease.
OBJECTIVE
We investigated the plasma levels of endothelin 1/2 in patients with acute symptoms relating to a known or newly diagnosed aortic aneurysm in order to investigate the possible role of peptides in the development of the disease.


METHODS
Endothelin 1/2 plasma levels were determined in patients admitted to the emergency unit with suspected acute aortic disease. The history, type of aneurysm, outcome and laboratory findings were determined and compared to endothelin 1/2 levels collected on admission.


RESULTS
In patients with ruptured aneurysm (n=27) or acute aortic dissection (n=18) the endothelin 1/2 median levels were higher 1.1 (25th and 75th quartile 0.7, 1.7) fmol/ml than in patients (n=20) with pre-existing aneurysm 0.7 (0.4, 1.1) fmol/ml (P=0.013). Patients who died had significantly higher endothelin levels 1.3 (0.8, 1.9) fmol/ml than the survivors 0.8 (0.5, 1.4) fmol/ml (P=0.04). In a logistic regression analysis, only a higher blood pressure on admission was an independent predictor of survival.


CONCLUSIONS
Endothelin 1/2 levels are elevated in patients with acute dissection or ruptured aneurysm, but they are not an independent predictor of survival.
Wagner
Andreas
A
Department of Emergency Medicine, University of Vienna, Vienna General Hospital, Vienna, Austria.
Domanovits
Hans
H
Holzer
Michael
M
Kofler
Julia
J
Röggla
Martin
M
Müllner
Markus
M
Oschatz
Elisabeth
E
Prager
Manfred
M
Grimm
Michael
M
Sterz
Fritz
F
Laggner
Anton N
AN
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000097:blood*; D019332:Endothelin-1 / Q000097:blood*; D019333:Endothelin-2 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
D019332:Endothelin-1; D019333:Endothelin-2