Protein kinase C-theta;: signaling from the center of the T-cell synapse.
The hypothesis that protein kinase C (PKC)-theta; plays an important role in T-lymphocyte activation, as indicated by numerous studies in cell lines, was recently confirmed in mice deficient in the expression of this enzyme. In response to TCR stimulation, peripheral T cells lacking PKC-theta; failed to activate NF-kappaB and AP-1, and to express IL-2. This revealed a critical function for this PKC family member in linking membrane-proximal activation cascades to transcriptional responses governing T-cell activation. Although the molecular interactions in which PKC-theta; engages have not been fully delineated, insights from a variety of recent studies have permitted new models to be formulated regarding the mechanisms through which it achieves its unique effector functions.
Arendt
Christopher W
CW
Howard Hughes Medical Institute and Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
Albrecht
Björn
B
Soos
Timothy J
TJ
Littman
Dan R
DR
D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D004789:Enzyme Activation; D006801:Humans; D016023:Integrins / Q000502:physiology; D007527:Isoenzymes / Q000502:physiology*; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D011493:Protein Kinase C / Q000502:physiology*; D000074121:Protein Kinase C-theta; D013569:Synapses / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*; D018808:Transcription Factor AP-1 / Q000378:metabolism
D016023:Integrins; D007527:Isoenzymes; D016328:NF-kappa B; D018808:Transcription Factor AP-1; C076233:PRKCQ protein, human; C489593:Prkcq protein, mouse; D011493:Protein Kinase C; D000074121:Protein Kinase C-theta