title: Invasive papillary adenocarcinoma of the colon.
abstract: Colonic adenocarcinomas are among the most common type of tumors. In this report, we present the morphologic, immunohistochemical, and microsatellite findings of 2 cases with a distinct invasive papillary component. Both tumors arose from polyps in middle-aged patients, followed an aggressive course, and showed a superficial adenomatous component. The immunohistochemical stains showed that the tumor cells were negative for p27 and p53; both tumors were microsatellite stable, that is, with no microsatellite instability in the 6 markers studied, and there was no loss of the mismatch repair proteins hMSH2 or hMLH1. These findings suggest that these tumors follow the tumor-suppressor pathway and represent an aggressive subtype of colonic adenocarcinoma.
authors.affiliation: Department of Pathology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Juan P
authors.initials: JP
authors.lastname: Palazzo
authors.forename: Tina Bocker
authors.initials: TB
authors.lastname: Edmonston
authors.forename: Linda M
authors.initials: LM
authors.lastname: Chaille-Arnold
authors.forename: Susan
authors.initials: S
authors.lastname: Burkholder
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000231:Adenocarcinoma, Papillary / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D018253:Adenoma, Villous / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002352:Carrier Proteins; D003110:Colonic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D004268:DNA-Binding Proteins; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein; D009363:Neoplasm Proteins / Q000032:analysis; D016609:Neoplasms, Second Primary; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins / Q000032:analysis
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; C501486:MLH1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; C497172:MSH2 protein, human; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein