title: Systemic acute-phase response after laparoscopic and open cholecystectomy.
abstract: BACKGROUND
  Cytokines are the main mediators of inflammation and the response to trauma. The purpose of this study was to compare variations in cytokine levels following laparoscopic cholecystectomy (LC) and mini-laparotomy cholecystectomy (OC), since these two types of operations were considered to be a unique model for examining the role of local tissue injury in postoperative inflammatory reactions.
  
  
  METHODS
  A total of 40 patients were studied. Eighteen of them underwent LC; the remaining 22 were operated on using the open technique. Systemic concentrations of interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor (TNF), and C-reactive protein (CRP) were measured before and after the operation. In addition, we compared pre- and postoperative white blood cell (WBC) counts, postoperative body temperature, and length of postoperative hospitalization.
  
  
  RESULTS
  There was no difference between the two groups in IL-1 and TNF response. The rise in plasma IL-6 levels (18.86 +/- 9.61 vs 5.00 +/- 0.0 pg/ml, p < 0.0001) and CRP (8.40 +/- 5.81 vs 1.43 +/- 1.30 mg/dl, p < 0.001) were more marked after open cholecystectomy than after the laparoscopic procedure. There was no correlation between serum CRP concentrations and the other postoperative parameters.
  
  
  CONCLUSIONS
  The magnitude of the acute-phase response was less pronounced following laparoscopic cholecystectomy, consistent with a reduction in tissue trauma.
authors.affiliation: Department of Surgery, University of Rome Tor Vergata, via di Tor Vergata 135, 00131 Rome, Italy. grande@med.uniroma2.it
authors.forename: M
authors.initials: M
authors.lastname: Grande
authors.forename: G F
authors.initials: GF
authors.lastname: Tucci
authors.forename: O
authors.initials: O
authors.lastname: Adorisio
authors.forename: A
authors.initials: A
authors.lastname: Barini
authors.forename: F
authors.initials: F
authors.lastname: Rulli
authors.forename: A
authors.initials: A
authors.lastname: Neri
authors.forename: F
authors.initials: F
authors.lastname: Franchi
authors.forename: A M
authors.initials: AM
authors.lastname: Farinon
mesh_terms: D000210:Acute-Phase Reaction / Q000097:blood / Q000209:etiology*; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D002763:Cholecystectomy / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D010535:Laparoscopy / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein