[Experimental studies on procedures and properties of natural derived scaffold materials of tissue engineered bone].
To detect the properties of natural xenogeneic bone derived materials which were processed with different physical and chemical treatments, we made fully deproteinized bone(FDB), partially deproteinized bone (PDPB), partially decalcified bone(PDCB) from pig ribs. Their morphological features, constitute components and mechanical properties were examined by scanning electron microscopy, x-rays diffraction analysis, mechanical assay and so on. The results showed that FDB, PDPB and PDCB maintained natural network pore system. The ratios of calcium to phosphorus were 1.81, 1.74 and 1.50, and the protein contents were 0.01% +/- 0.02%, 22.41% +/- 0.83% and 35.75% +/- 2.12% respectively. The sequence of their mechanic strength was PDCB > PDPB > FDB. These data indicate that FDB, PDPB and PDCB possess natural network pore system. Their organic and inorganic component ratios and contents are different, so their mechanic properties are not alike. Additionally, more investigations will be necessary to detect the biocompatibility of the three different scaffold materials of natural derived bone.
Li
Yanlin
Y
Department of Orthopedic Surgery, West China Hospital of Sichuan University, Chengdu 610041.
Yang
Zhiming
Z
Xie
Huiqi
H
Qin
Tingwu
T
Huang
Fuguo
F
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000737:chemistry; D008422:Materials Testing; D013552:Swine; D023822:Tissue Engineering
D001672:Biocompatible Materials