title: A stochastic nonlinear autoregressive algorithm reflects nonlinear dynamics of heart-rate fluctuations.
abstract: Current methods for detecting nonlinear determinism in a time series require long and stationary data records, as most of them assume that the observed dynamics arise only from the internal, deterministic workings of the system, and the stochastic portion of the signal (the noise component) is assumed to be negligible. To explicitly account for the stochastic portion of the data we recently developed a method based on a stochastic nonlinear autoregressive (SNAR) algorithm. The method iteratively estimates nonlinear autoregressive models for both the deterministic and stochastic portions of the signal. Subsequently, the Lyapunov exponents (LE) are calculated for the estimated models in order to examine if nonlinear determinism is present in the deterministic portion of the fitted model. To determine if nonlinear dynamic analysis of heart-rate fluctuations can be used to assess arrhythmia susceptibility by predicting the outcome of invasive cardiac electrophysiologic study (EPS), we applied the SNAR algorithm to noninvasively measured resting sinus-rhythm heart-rate signals obtained from 16 patients. Our analysis revealed that a positive LE was highly correlated to a patient with a positive outcome of EPS. We found that the statistical accuracy of the SNAR algorithm in predicting the outcome of EPS was 88% (sensitivity=100%, specificity=75%, positive predictive value=80%, negative predictive value=100%, p=0.0019). Our results suggest that the SNAR algorithm may serve as a noninvasive probe for screening high-risk populations for malignant cardiac arrhythmias.
authors.affiliation: Division of Health Sciences and Technology, Harvard University-Massachusetts Institute of Technology, Cambridge, USA.
authors.forename: Antonis A
authors.initials: AA
authors.lastname: Armoundas
authors.forename: Kihwan
authors.initials: K
authors.lastname: Ju
authors.forename: Nikhil
authors.initials: N
authors.lastname: Iyengar
authors.forename: Jorgen K
authors.initials: JK
authors.lastname: Kanters
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Saul
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Cohen
authors.forename: Ki H
authors.initials: KH
authors.lastname: Chon
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D003198:Computer Simulation; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D015233:Models, Statistical; D017711:Nonlinear Dynamics; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013269:Stochastic Processes; D014693:Ventricular Fibrillation / Q000175:diagnosis*