Highly diastereoselective synthesis of decalin skeletons with quaternary carbon centers via the tandem oxy-Cope/ene/Claisen reaction.
The highly diastereoselective cascade sequence of three successive thermal pericyclic reactions of 1,2-divinylcyclohexanol allyl and propargyl ethers is described. This novel tandem process provides an efficient synthesis of sesqui- and diterpenoid skeletons having a quaternary carbon at C9. [reaction: see text]
Barriault
Louis
L
Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5. lbarriau@science.uottawa.ca
Denissova
Irina
I