title: [Aortoiliac reconstruction after kidney transplantation. Strategies to avoid ischemic damage of the transplant].
abstract: BACKGROUND
  The rising life expectancy of patients undergoing kidney transplantation and the improvement in the function rate of the allografts have led to an increasing number of patients suffering from arteriosclerosis-related diseases of the aortoiliac arteries. In these particular cases, an interruption of the blood supply of the allograft is always necessary for operative repair of the aortic and iliac arteries. This means a high risk of ischemic damage to the transplanted kidney.
  
  
  METHODS
  Between 1987 and 2000, 1,076 kidney transplantations were performed in our department. During this time, 14 reconstructive operations of the aortoiliac arteries were performed in 12 patients (6 women, 6 men, average age 55.2 (45-71) years). Operations were indicated in patients suffering from occlusive disease with imminent extremity or allograft loss, and symptomatic or asymptomatic aneurysms with a maximum diameter of more than 4 cm. In patients presenting with thoracoabdominal (1) and abdominal aortic aneurysms (3), protection of the transplanted kidney was performed by axilloiliac or axillofemoral bypass. Hypothermic flush-perfusion of the allograft containing PGE1 and heparin was performed in seven of nine operations for occlusive disease.
  
  
  RESULTS
  None of the patients presented with a permanent decrease in kidney function, six patients showed temporary creatinine elevation, and in nine patients creatinine levels at discharge were lower than they were preoperatively. None of the patients died.
  
  
  CONCLUSIONS
  Reviewing all reported methods of allograft protection, we recommend a three-step strategy including sequential clamp technique (ischemia < 30 min.), hypothermic flush-perfusion (ischemia < or = 60 min.), and temporary axilloiliac/femoral shunt (ischemia > 60 min), depending on the expected renal ischemia time.
authors.affiliation: Klinik für Gefässchirurgie und Nierentransplantation, Heinrich-Heine-Universität, Moorenstrasse 5, 40225 Düsseldorf. tomas.pfeiffer@uni-duesseldorf.de
authors.forename: T
authors.initials: T
authors.lastname: Pfeiffer
authors.forename: H
authors.initials: H
authors.lastname: Böhner
authors.forename: B
authors.initials: B
authors.lastname: Luther
authors.forename: A
authors.initials: A
authors.lastname: Voiculescu
authors.forename: B
authors.initials: B
authors.lastname: Grabensee
authors.forename: W
authors.initials: W
authors.lastname: Sandmann
mesh_terms: D000368:Aged; D000792:Angiography; D001012:Aorta, Abdominal / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007083:Iliac Artery / Q000601:surgery*; D007511:Ischemia / Q000517:prevention & control*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation; D013997:Time Factors; D014656:Vascular Surgical Procedures
chemical_list: D003404:Creatinine