title: Design, synthesis and bioactivity evaluation of tribactam beta lactamase inhibitors.
abstract: Known carbapenem compounds with inhibitory effect towards beta-lactamase enzymes are formed from bicyclical beta lactam structural scaffolds. On the basis of results from theoretical computational methods and molecular modelling we have designed and developed a synthetic route towards novel, biologically active tricyclic derivatives of carbapenems.
authors.affiliation: Lek d.d., Research and Development, Celovska 135, 1526, Ljubljana, Slovenia.
authors.forename: Anton
authors.initials: A
authors.lastname: Copar
authors.forename: Tadeja
authors.initials: T
authors.lastname: Prevec
authors.forename: Borut
authors.initials: B
authors.lastname: Anzic
authors.forename: Tomaz
authors.initials: T
authors.lastname: Mesar
authors.forename: Lovro
authors.initials: L
authors.lastname: Selic
authors.forename: Mateja
authors.initials: M
authors.lastname: Vilar
authors.forename: Tom
authors.initials: T
authors.lastname: Solmajer
mesh_terms: D001409:Bacillus cereus / Q000201:enzymology; D015780:Carbapenems / Q000138:chemical synthesis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006868:Hydrolysis / Q000187:drug effects; D008958:Models, Molecular; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams / Q000378:metabolism
chemical_list: D015780:Carbapenems; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams