Recovery of injured adrenal medulla by differentiation of pre-existing undifferentiated chromaffin cells.
We described previous that the adrenal medulla recovers rapidly from the injuries due to salinomycin. In the present study we found the recovery to be apparently due to differentiation of pre-existing, primitive undifferentiated, chromaffin cells, rather than mitosis, as evidenced by lack of incorporation of 5-bromo-2-deoxyuridine in the differentiating and/or differentiated chromaffin cells. Electron-dense, striated fibrils observed within the necrotic cells and in the extracellular space were presumed to be intermediate degradation products. Schwann cells actively functioned as phagocytes in this study, and seemed to indirectly stimulate the differentiation of undifferentiated chromaffin cells.
Chen-Pan
Cleo
C
Department of Veterinary Anatomy, Faculty of Agriculture, The University of Tokyo, Japan. ijpan@brs.nihou-u.ac.jp
Pan
In Jen
IJ
Yamamoto
Yuzuru
Y
Chen
Hans H C
HH
Hayashi
Yoshiro
Y
D000313:Adrenal Medulla / Q000473:pathology*; D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002454:Cell Differentiation; D019439:Chromaffin Cells / Q000502:physiology* / Q000648:ultrastructure; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D017207:Rats, Sprague-Dawley; D012583:Schwann Cells / Q000648:ultrastructure
D001973:Bromodeoxyuridine