HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection.
We have previously shown that Vpu is rarely targeted by HIV-1-specific cytotoxic T lymphocytes (CTL). The present report extends these findings and describes the characterization of the first CTL epitope within HIV-1 Vpu, identified in an individual with long-term non-progressive HIV-1 infection. The epitope was shown to be highly conserved among HIV clade B sequences and is restricted by HLA-A*3303, an HLA allele commonly seen in Asian and west-African populations.
Addo
Marylyn M
MM
Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Altfeld
Marcus
M
Rathod
Almas
A
Yu
Michelle
M
Yu
Xu G
XG
Goulder
Philip J R
PJ
Rosenberg
Eric S
ES
Walker
Bruce D
BD
D000595:Amino Acid Sequence; D016384:Consensus Sequence; D003602:Cytotoxicity, Immunologic; D018450:Disease Progression; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000276:immunology*; D015234:HLA-A Antigens / Q000276:immunology*; D054298:Human Immunodeficiency Virus Proteins; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D054334:Viral Regulatory and Accessory Proteins / Q000276:immunology*; D000086082:Viroporin Proteins
D015234:HLA-A Antigens; D054298:Human Immunodeficiency Virus Proteins; D010446:Peptide Fragments; D054334:Viral Regulatory and Accessory Proteins; C082945:HLA-A*33 antigen; C514859:vpu protein, Human immunodeficiency virus 1; D000086082:Viroporin Proteins