In vitro activity of linezolid against Clostridium difficile.
We examined the in vitro activity of linezolid against Clostridium difficile, including isolates with reduced susceptibility to metronidazole or vancomycin. The MIC at which 50% of the isolates were inhibited (MIC50) and MIC90 were 0.5 and 2 microg/ml, respectively (range, 0.03 to 4 microg/ml). MICs were always <or= 4 microg/ml, and thus, all isolates were considered susceptible.
Peláez
T
T
Microbiology and Infectious Diseases Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Alonso
R
R
Pérez
C
C
Alcalá
L
L
Cuevas
O
O
Bouza
E
E
D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects*; D003967:Diarrhea / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology; D006801:Humans; D000069349:Linezolid; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000592:standards; D023303:Oxazolidinones / Q000494:pharmacology*; D020713:Vancomycin Resistance
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D008795:Metronidazole; D000069349:Linezolid