Axillary node status in breast cancer patients prior to surgery by imaging with Tc-99m humanised anti-PEM monoclonal antibody, hHMFG1.
In early breast cancer axillary nodes are usually impalpable and over 50% of such patients may have an axillary clearance when no nodes are involved. This work identifies axillary node status by imaging with a Tc-99m radiolabelled anti-Polymorphic Epithelial Mucin, humanised monoclonal antibody (human milk fat globule 1), prior to surgery in 30 patients. Change detection analysis of image data with probability mapping is undertaken. A specificity of 93% and positive predictive value of 92% (both 100% if a second cancer in the axilla with negative nodes is considered) were found. A strategy for combining negative imaging with the sentinel node procedure is presented.
Al-Yasi
A R
AR
Department of Nuclear Medicine, St Bartholomew's Hospital, London EC1A 7BE, UK.
Carroll
M J
MJ
Ellison
D
D
Granowska
M
M
Mather
S J
SJ
Wells
C A
CA
Carpenter
R
R
Britton
K E
KE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001940:Breast / Q000000981:diagnostic imaging; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008875:Middle Aged; D018396:Mucin-1 / Q000276:immunology*; D016719:Radioimmunodetection; D013667:Technetium
D018396:Mucin-1; D013667:Technetium