[Two fatal cases of methotrexate-induced interstitial pneumonitis].
We report two cases of methotrexate-induced pneumonitis. Both patients died despite steroid pulse therapy. Postmortem lung tissue revealed diffuse alveolar damage, and focal lung fibrosis. Physicians should be aware of the possibility of MTX-induced interstitial pneumonitis in diagnosing RA patients with MTX when diffuse pulmonary infiltration is present.
Matsushima
Hidekazu
H
Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Saitama, Japan.
Takayanagi
Noboru
N
Kawata
Ichiro
I
Sakamoto
Tatsuhiko
T
Motegi
Mitsuru
M
Ubukata
Mikio
M
Yanagisawa
Tsutomu
T
Sugita
Yutaka
Y
Kanazawa
Minoru
M
Kawabata
Yoshinori
Y
D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D017809:Fatal Outcome; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*
D018501:Antirheumatic Agents; D008727:Methotrexate