title: Vestibular analyzer as a critical organ in the evaluation of radiation hazards during space flights.
abstract: During space flights the vestibular analyzer functions under conditions which are not usual for Earth environments. The vestibular analyzer periodically or constantly experiences the action of angular, linear or Coriolis acceleration combined with ionizing radiation. The quantitative evaluation of the functional state of the vestibular analyzer made it possible to obtain material on semicircular canal activity disturbances at different periods of radiation sickness and responses of the irradiated body, given various doses of gamma radiation, to angular and Coriolis acceleration. Experiments were performed on 250 rabbits and 22 dogs. Rabbits were exposed to the total gamma radiation at doses of 50, 100, 500, 800, 5000, 10000 rad; dogs experienced single and fractional radiation exposures at doses of 200 rad (gamma-rays) and at doses of 500 and 350 rad (protons of 510 MeV). Specific conditions under which the astronaut's vestibular analyzer is functioning during space missions and our own experimental results make it possible to state that the vestibular analyzer serves as the critical organ in evaluation of radiation hazards during space flights.
authors.affiliation: USSR.
authors.forename: Y G
authors.initials: YG
authors.lastname: Grigoryev
mesh_terms: D000054:Acceleration; D000328:Adult; D000818:Animals; D003312:Coriolis Force; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D004594:Electrophysiology; D006801:Humans; D008297:Male; D009430:Neural Analyzers / Q000528:radiation effects*; D010037:Otolithic Membrane / Q000528:radiation effects; D011817:Rabbits; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental; D012934:Social Isolation; D013997:Time Factors; D014722:Vestibule, Labyrinth / Q000502:physiology / Q000528:radiation effects*