Probing the overlap of chorismate mutase and prephenate dehydrogenase sites in the escherichia coli T-protein: a dehydrogenase-selective inhibitor.
An inhibitor of prephenate dehydrogenase has been identified that has no effect on the chorismate mutase activity in the Escherichia coli T-protein, thus supporting the idea of two separate active sites.
Vincent
Sarah
S
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Chen
Shuqing
S
Wilson
David B
DB
Ganem
Bruce
B
D001665:Binding Sites; D002826:Chorismate Mutase / Q000187:drug effects / Q000378:metabolism*; D004791:Enzyme Inhibitors; D004926:Escherichia coli / Q000737:chemistry; D007700:Kinetics; D011303:Prephenate Dehydrogenase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D011303:Prephenate Dehydrogenase; D002826:Chorismate Mutase