title: [Buspirone increases D2-like dopaminergic receptor density in rat corpus striatum].
abstract: Buspirone (busp) a piperazinyl derivative with anxiolytic properties is a partial agonist on 5-HT1A with affinity for D2-like dopaminergic receptors (RD2). The objective of this study was to verify the effects of busp on RD2. Female Wistar rats 150-200 g were treated with busp (5 and 10 mg/kg, p.o.) 1 or 2 times daily for 7 days. Controls (C) received saline. The density of RD2 (fmol/mg protein) was determined through binding assays in striatum (ST) using [3H]-spiroperidol as radioligand. No alteration in Bmax or Kd values were seen after busp administration once a day. However, a RD2 upregulation of 55 % increase was observed after busp 2 times a day with no change in Kd values. The results showed that busp interact not only with serotonergic, but also with dopaminergic system.
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
authors.forename: Vera Targino Moreira
authors.initials: VT
authors.lastname: Lima
authors.forename: Danielle Silveira
authors.initials: DS
authors.lastname: Macedo
authors.forename: Carlos Renato Alves
authors.initials: CR
authors.lastname: Nogueira
authors.forename: Silvânia Maria Mendes
authors.initials: SM
authors.lastname: Vasconcelos
authors.forename: Glauce Socorro de Barros
authors.initials: GS
authors.lastname: Viana
authors.forename: Francisca Cléa Florenço de
authors.initials: FC
authors.lastname: Sousa
mesh_terms: D000818:Animals; D002065:Buspirone / Q000008:administration & dosage / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000187:drug effects* / Q000378:metabolism; D018490:Serotonin Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D017448:Receptors, Dopamine D2; D018490:Serotonin Agents; D002065:Buspirone