title: Colchicine effect in a colonic hyperplastic polyp. A lesion mimicking serrated adenoma.
abstract: Colchicine effect has been described recently in gastrointestinal biopsies, where it can result in accumulation of metaphase mitoses and epithelial disorganization. We describe the case of a colonic hyperplastic polyp with colchicine effect from a 52-year-old woman who was receiving colchicine for primary biliary cirrhosis. Biopsy of the polyp revealed prominent metaphase mitoses and focal loss of nuclear polarity in the surface epithelium, features that mimicked a serrated adenoma. Distinguishing between hyperplastic polyp and serrated adenoma is important because of the different management implications and the increased potential for neoplastic progression in the latter.
authors.affiliation: Division of Gastrointestinal/Liver Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Torbenson
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Montgomery
authors.forename: Christine
authors.initials: C
authors.lastname: Iacobuzio-Donahue
authors.forename: John H
authors.initials: JH
authors.lastname: Yardley
authors.forename: Tsung-Teh
authors.initials: TT
authors.lastname: Wu
authors.forename: Susan C
authors.initials: SC
authors.lastname: Abraham
mesh_terms: D000236:Adenoma / Q000473:pathology*; D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor / Q000032:analysis; D016764:Cell Polarity / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000737:chemistry / Q000473:pathology*; D003111:Colonic Polyps / Q000737:chemistry / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008875:Middle Aged; D008938:Mitosis / Q000187:drug effects; D009687:Nuclear Proteins / Q000032:analysis
chemical_list: D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D003078:Colchicine