title: The use of a supported base and strong cation exchange (SCX) chromatography to prepare a variety of structurally-diverse molecular libraries prepared by solution-phase methods.
abstract: The preparation of molecular libraries of aminomethylbiaryls, allylic amines, and ethanolamines using solution-phase methodology is described. In particular, the use of a solid-supported base reagent (PTBD resin) and strong cation exchange(SCX) resin to effect 'catch and release' purification across these diverse libraries is highlighted.
authors.affiliation: Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada. organ@yorku.ca
authors.forename: M G
authors.initials: MG
authors.lastname: Organ
authors.forename: C E
authors.initials: CE
authors.lastname: Dixon
authors.forename: D
authors.initials: D
authors.lastname: Mayhew
authors.forename: D J
authors.initials: DJ
authors.lastname: Parks
authors.forename: E A
authors.initials: EA
authors.lastname: Arvanitis
mesh_terms: D000478:Alkylation; D000588:Amines / Q000138:chemical synthesis*; D002412:Cations; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D020650:Combinatorial Chemistry Techniques; D004983:Ethanolamines / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis*; D012116:Resins, Plant / Q000737:chemistry; D012996:Solutions; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000588:Amines; D002412:Cations; D004983:Ethanolamines; D007202:Indicators and Reagents; D011084:Polycyclic Aromatic Hydrocarbons; D012116:Resins, Plant; D012996:Solutions; D012997:Solvents