Bacterial avoidance of phagocytosis.
Phagocytosis constitutes the primary line of host innate and adaptive defence against incoming microbial pathogens, providing an efficient means for their removal and destruction. However, several virulent bacteria that do not function as intracellular pathogens have evolved mechanisms to avoid and prevent phagocytosis that constitute an essential part of their pathogenic capacity. Some of these mechanisms include preventing recognition by phagocytic receptors or blocking uptake by professional phagocytes. Recently, the molecular mechanisms of such antiphagocytic properties have been elucidated for some pathogens. Such mechanisms illustrate the diversity of mechanisms bacterial pathogens use to avoid phagocytic uptake.
Celli
Jean
J
Biotechnology Laboratory, University of British Columbia, Room 237, 6174 University Boulevard, Vancouver, BC, Canada V6T 1Z3. bfinlay@interchange.ubc.ca
Finlay
B Brett
BB
D000942:Antigens, Bacterial / Q000276:immunology; D001419:Bacteria / Q000276:immunology / Q000472:pathogenicity*; D018448:Models, Immunological; D010587:Phagocytosis; D015398:Signal Transduction
D000942:Antigens, Bacterial