title: Repeated doses of tissue plasminogen activator for failed thrombolysis: case report and review of the literature.
abstract: This article reports the first case of a patient presenting with acute myocardial infarction in whom a repeated dose of tissue plasminogen activator (t-PA) was able to achieve successful thrombolysis after a first dose of t-PA itself failed to do so. This case report presents an alternative approach for the treatment of patients who fail thrombolysis after an initial dose of t-PA, an approach that might be particularly useful in hospitals that do not have immediate access to advanced interventional services.
authors.affiliation: Division of Cardiology, Department of Medicine, American University of Beirut Medical Center, Beirut, Lebanon. hd01@aub.edu.lb
authors.forename: H A
authors.initials: HA
authors.lastname: Dakik
authors.forename: A
authors.initials: A
authors.lastname: Nasrallah
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D010960:Plasminogen Activators / Q000008:administration & dosage / Q000627:therapeutic use*; D019233:Retreatment; D015912:Thrombolytic Therapy; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator