The influences of maternal albumin concentrations on the placental transfer of propofol in human dually perfused cotyledon in vitro.
These results indicate that fetal exposure to propofol can vary considerably depending on maternal plasma albumin concentration. A fractional change in the maternal protein binding of propofol can result in a relatively large difference in fetal exposure.
He
Yan-Ling
YL
Department of Anesthesiology, Hyogo College of Medicine, Nishinomiya City, Japan. Yhe@partners.org
Seno
Hiroshi
H
Sasaki
Ken
K
Tashiro
Chikara
C
D018686:Anesthetics, Intravenous / Q000493:pharmacokinetics*; D001692:Biological Transport; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D010477:Perfusion; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D015742:Propofol / Q000493:pharmacokinetics*; D012709:Serum Albumin / Q000032:analysis*
D018686:Anesthetics, Intravenous; D012709:Serum Albumin; D015742:Propofol