Sequence of two new HLA-Cw alleles: HLA-Cw*0313 and HLA-Cw*1208.
Two new HLA-C alleles have been identified by reverse line blot assay and direct sequencing of polymerase chain reaction (PCR) products. The first polymorphism encodes an amino acid change from lysine in Cw*12022 to asparagine in Cw*1208 at residue 66. The second polymorphism encodes two amino acid changes from isoleucine in Cw*03031 to threonine in Cw*0313 at residue 93 and isoleucine to leucine at residue 94. The functional significance of these polymorphisms on peptide-binding and/or T-cell recognition is unknown.
Cox
S T
ST
The Anthony Nolan Research Institute and Histocompatibility Laboratories, London, United Kingdom.
Ogilvie
H
H
Bohan
E M
EM
Holman
R
R
Prentice
H G
HG
Potter
M
M
Madrigal
J A
JA
Little
A-M
AM
D000483:Alleles; D005805:Genes, MHC Class I; D015236:HLA-C Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000473:pathology; D017422:Sequence Analysis, DNA; D020539:Sequence Analysis, Protein
D015236:HLA-C Antigens; C466438:HLA-C*03:13 antigen; C466439:HLA-C*12:09 antigen