Colchicine-induced rhabdomyolysis.
OBJECTIVE
To report a case of rhabdomyolysis occurring during treatment with colchicine.


METHODS
A 44-year-old African American man was admitted to the hospital due to persistent diarrhea, vomiting, and diffuse weakness. Past medical history was significant for renal failure requiring peritoneal dialysis, gout, and a new skin lesion. Approximately 2 months prior to admission, he had been started on colchicine and allopurinol. Creatine kinase concentration on admission was >14 000 U/L. Liver function tests were elevated 5 times the upper limit of normal. Colchicine was discontinued on admission. Creatine kinase concentrations decreased significantly, and strength and ambulation improved throughout hospitalization.


CONCLUSIONS
Colchicine was thought to be the causative factor for rhabdomyolysis in conjunction with chronic renal failure and elevated liver function tests. After discontinuation of colchicine, creatinine kinase concentrations declined and the patient's ability to walk improved. Limited case reports of colchicine-induced rhabdomyolysis have been published.


CONCLUSIONS
Chronic renal failure in conjunction with elevated liver function tests appear to increase the possibility of colchicine-induced toxicity, specifically, rhabdomyolysis.
Boomershine
Kellie H
KH
Pharmacy Department, Trident Health System, 9330 Medical Plaza Dr., Charleston, SC 29406-9104, USA. Kellie.Boomershine@HCAHealthcare.com
D000328:Adult; D000493:Allopurinol / Q000009:adverse effects / Q000627:therapeutic use; D003078:Colchicine / Q000009:adverse effects* / Q000627:therapeutic use; D003967:Diarrhea / Q000139:chemically induced; D006073:Gout / Q000188:drug therapy; D006074:Gout Suppressants / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012206:Rhabdomyolysis / Q000139:chemically induced*; D014839:Vomiting / Q000139:chemically induced
D006074:Gout Suppressants; D000493:Allopurinol; D003078:Colchicine