Rapid prenatal diagnosis of trisomies 13, 18, 21 and sex chromosome anomalies by fluorescence in situ hybridization: a year's experience.
The present paper summarizes our first 12 months' experiences of rapid prenatal diagnosis using commercially available diagnostic fluorescence in situ hybridization (FISH) probes for chromosomes X, Y, 13, 18 and 21. The data clearly demonstrate that the advantage of using FISH as an adjunct technique is the fast and reliable determination of the common fetal chromosomal aneuploidies; the results are available in less than 24 hours instead of the 7-14 days with standard techniques.
Li
Shibo
S
Department of Pediatrics, University of Oklahoma Health Sciences Center, 941 Stanton L. Young Blvd., BSEB 224, Oklahoma City, OK 73104, USA. shibo-li@ouhsc.edu
Stanley
John R
JR
Draper
Michael L
ML
Mirabile
Charles P
CP
Coleman
Fred H
FH
Mulvihill
John J
JJ
D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D015342:DNA Probes; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011933:Reagent Kits, Diagnostic; D013997:Time Factors
D015342:DNA Probes; D011933:Reagent Kits, Diagnostic