title: Paroxysmal episodic central thermoregulatory failure.
abstract: A 51-year-old man presenting with paroxysmal attacks of unilateral sweating for 1 year was studied. Clinical and laboratory findings made the diagnosis of Shapiro or Harlequin syndrome unlikely. The onset of the sweating "crisis" was immediately followed by a progressive decrease in rectal and skin temperature, lasting for about 2 hours. This indicated that hypothermia was related to an abnormal downward shift of the thermoregulatory set point and a delayed effect of mechanisms blocking heat dissipation.
authors.affiliation: Institute of Neurology, University of Bologna, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Magnifico
authors.forename: G
authors.initials: G
authors.lastname: Pierangeli
authors.forename: G
authors.initials: G
authors.lastname: Barletta
authors.forename: C
authors.initials: C
authors.lastname: Candela
authors.forename: P
authors.initials: P
authors.lastname: Montagna
authors.forename: G
authors.initials: G
authors.lastname: Bonavina
authors.forename: P
authors.initials: P
authors.lastname: Cortelli
mesh_terms: D001341:Autonomic Nervous System / Q000502:physiology; D001833:Body Temperature Regulation / Q000502:physiology*; D006801:Humans; D007035:Hypothermia / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000294:innervation / Q000503:physiopathology; D013546:Sweating / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000503:physiopathology; D013577:Syndrome