Tsg101: HIV-1's ticket to ride.
Recent studies implicate the vacuolar protein-sorting pathway in the transport of the retroviral structural precursor (Gag) protein to its budding site on the plasma membrane of infected cells. This exploitation of the cellular endocytic trafficking machinery to release viral particles could lead to the identification of virus-specific modulators and provide opportunities to design new targeted anti-viral agents.
Carter
Carol A
CA
Department of Molecular Genetics & Microbiology, Life Sciences Bldg, SUNY at Stony Brook, Stony Brook, NY 11794-5222, USA. ccarter@ms.cc.sunysb.edu
D000251:Adenosine Triphosphatases; D004268:DNA-Binding Proteins / Q000378:metabolism; D056827:Endosomal Sorting Complexes Required for Transport; D005656:Fungal Proteins / Q000378:metabolism; D015683:Gene Products, gag / Q000737:chemistry / Q000378:metabolism*; D015497:HIV-1 / Q000254:growth & development / Q000378:metabolism*; D006801:Humans; D021381:Protein Transport; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism; D014617:Vacuoles / Q000378:metabolism; D000099177:Tsg101 Protein
D000251:Adenosine Triphosphatases; D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D005656:Fungal Proteins; D015683:Gene Products, gag; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D025801:Ubiquitin; D000099177:Tsg101 Protein; C107528:VPS4 protein, S cerevisiae