title: Leaching of diethylhexyl phthalate from polyvinyl chloride bags into intravenous etoposide solution.
abstract: OBJECTIVE
  To compare the release of diethylhexyl phthalate (DEHP) from polyvinyl chloride (PVC) bags from four different manufacturers into intravenous etoposide solutions.
  
  
  METHODS
  Etoposide solutions, 0.4 mg/mL, containing the vehicle polysorbate 80 were prepared in 5% dextrose or 0.9% sodium chloride injection PVC bags and stored at room temperature for 24 h. DEHP content was analysed by high-performance liquid chromatography.
  
  
  RESULTS
  Substantial amounts of DEHP (up to 20 microg/mL at room temperature) leached into the etoposide solutions. However, no significant differences were found in the amounts of DEHP leached into the etoposide infusion solutions prepared using either 5% dextrose or 0.9% sodium chloride injection and stored in the four different containers.
  
  
  CONCLUSIONS
  To minimize patient exposure o DEHP, etoposide solutions should ideally be stored in a glass or polyolefin container.
authors.affiliation: Pharmacie Brabois Adultes - Centre Hospitalier Universitaire de Nancy, Allée du Morvan, Vandoeuvre-les-Nancy, France. bdemore@club-internet.fr
authors.forename: B
authors.initials: B
authors.lastname: Demoré
authors.forename: J
authors.initials: J
authors.lastname: Vigneron
authors.forename: A
authors.initials: A
authors.lastname: Perrin
authors.forename: M A
authors.initials: MA
authors.lastname: Hoffman
authors.forename: M
authors.initials: M
authors.lastname: Hoffman
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry*; D004051:Diethylhexyl Phthalate / Q000737:chemistry*; D004340:Drug Contamination; D004356:Drug Storage; D005047:Etoposide / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D007262:Infusions, Intravenous; D011143:Polyvinyl Chloride / Q000737:chemistry*; D013696:Temperature
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide; D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate