Galanin-like peptide stimulates food intake in the rat.
We have isolated a novel hypothalamic peptide, Galanin-like peptide (GALP), as a ligand for galanin receptor subtype GalR2. To investigate the physiological role of GALP, we examined the effect of the intracerebroventricular administration of GALP and found that GALP induced food intakes. GALP had ten-fold the orexigenic activity of galanin. We also observed the anxiogenic-like behavior after the administration of 1 nmol GALP. These results suggest that GALP is a novel orexigenic and anxiogenic peptide.
Matsumoto
Yoshio
Y
Pharmaceutical Research Division, Takeda Chemical Industries Ltd., Jusohonmachi 2-17-85, Yodogawa, Osaka, 532-8686, Japan.
Watanabe
Takuya
T
Adachi
Yuka
Y
Itoh
Takashi
T
Ohtaki
Tetsuya
T
Onda
Haruo
H
Kurokawa
Tsutomu
T
Nishimura
Osamu
O
Fujino
Masahiko
M
D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D001069:Appetite Regulation / Q000187:drug effects / Q000502:physiology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D019004:Galanin / Q000378:metabolism* / Q000494:pharmacology; D044089:Galanin-Like Peptide; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism* / Q000494:pharmacology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D044089:Galanin-Like Peptide; D009419:Nerve Tissue Proteins; D019004:Galanin