Synthesis of a novel fluorescent probe for estrogen receptor.
A novel estradiol-mimetic fluorescent probe 5 was synthesized from diethylstilbestrol (DES, 1), which is useful for probing estrogen receptor (ERalpha), a prognostic indicator of estrogen-dependent cancers, and for developing a homogeneous fluorescence polarization (FP) assay to identify the ligands of estrogen receptor.
Adamczyk
Maciej
M
Department of Chemistry (9NM, Bldg AP20), Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6016, USA. maciej.adamczyk@abbott.com
Reddy
Rajarathnam E
RE
Yu
Zhiguang
Z
D004054:Diethylstilbestrol / Q000737:chemistry*; D005454:Fluorescence Polarization; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D008024:Ligands; D018716:Molecular Mimicry; D011960:Receptors, Estrogen / Q000737:chemistry* / Q000378:metabolism
D005456:Fluorescent Dyes; D008024:Ligands; D011960:Receptors, Estrogen; D004054:Diethylstilbestrol