Chiral synthesis and enzymatic resolution of (S)-(-)piperazine-2-carboxylic acid using enzyme alcalase.
Enantiomerically pure (S)-piperazine-2-carboxylic acid was synthesized by kinetic resolution of methyl-4-(tert-butyroxycarbonyl)-piperazine-2-carboxylate using a low cost enzyme alcalase.
Wu
G
G
ChemPacific Corporation, Baltimore, Maryland, USA.
Zhao
H
H
Luo
R G
RG
Wei
D
D
Malhotra
S V
SV
D002264:Carboxylic Acids / Q000138:chemical synthesis*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D010879:Piperazines / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013381:Subtilisins / Q000737:chemistry*
D002264:Carboxylic Acids; D010879:Piperazines; C453680:piperazine-2-carboxylic acid; D013381:Subtilisins