Effects of stereochemical aspects on drug interaction in pharmacokinetics.
Recent literatures on enantiomer/enantiomer and enantiomer/coadministered drug interactions in pharmacokinetics were reviewed. The clinical significance of introducing the concept of stereoselectivity into pharmacokinetic interaction study cannot be overestimated, such as avoiding interaction-based adverse reactions, increasing therapeutic index, resolving the apparent anomaly in the plasma concentration-effect relationship and providing starting point of investigation into drug disposition, etc. Study in this respect should be enhanced.
Zhou
Quan
Q
Department of Drug Metabolism & Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China.
Yao
Tong-Wei
TW
Zeng
Su
S
D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010599:Pharmacokinetics; D013237:Stereoisomerism
D004364:Pharmaceutical Preparations