Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors.
Benzimidazoles and their isosteric compounds as factor Xa inhibitors are discussed.
He
Wei
W
Department of Chemistry, Aventis Pharmaceuticals, Route 202-206, Bridgewater, NJ 08807, USA. whe@prius.jnj.com
Hanney
Barbara
B
Myers
Michael R
MR
Condon
Stephen
S
Becker
Michael R
MR
Spada
Alfred P
AP
Burns
Christopher
C
Brown
Karen
K
Colussi
Dennis
D
Chu
Valeria
V
D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D015951:Factor Xa / Q000378:metabolism; D065427:Factor Xa Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D013329:Structure-Activity Relationship
D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D065427:Factor Xa Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings; D015951:Factor Xa