Effects of ketamine on neuronal activity of the spinal dorsal horn   in rats with unilateral hindpaw inflammation.
A total of 32 units were extracellularly recorded from the spinal dorsal horn of rats. Unitary discharges evoked by stimulation of A and C fiber in ipsilateral lateral and medial plantar nerve were increased after carrageenan injection to the plantar area. The evoked responses to both A and C fiber were significantly decreased or even disappeared after administration of ketamine. The windup phenomenon was observed in neurons located deeply in the dorsal horn following carrageenan injection and was significantly suppressed or abolished after ketamine administration. The results above show NMDA receptor appears to be involved in the increase of excitability and the development of windup phenomenon in the spinal cord dorsal horn associated with carrageenan induced inflammation.
Guo
H
H
Department of Neurobiology, Capital University of Medical Sciences, Beijing 100054, China. gwlu@cpums.edu.cn
Li
Q J
QJ
Lu
G W
GW
D000818:Animals; D002351:Carrageenan; D005071:Evoked Potentials; D005260:Female; D005528:Foot; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology*; D007649:Ketamine / Q000494:pharmacology*; D009474:Neurons / Q000502:physiology; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013116:Spinal Cord / Q000503:physiopathology*
D016194:Receptors, N-Methyl-D-Aspartate; D007649:Ketamine; D002351:Carrageenan