title: Novel SNPs in a candidate gene, CRTH2, for allergic diseases.
abstract: Sequencing analyses of genomic DNA samples from a Chinese population identified four single-nucleotide polymorphisms (SNPs) of the CRTH2 gene, encoding a chemoattractant receptor predominantly expressed on Th2 cells and a receptor for prostaglandin D2 (PGD2). Two coding-region SNPs with a T to G and a C to A substitutions, resulting in codon changes from Phe to Val and Pro to Thr, respectively. Two additional SNPs were discovered in the 3' untranslated region (3'-UTR). These newly identified SNPs will be useful for further functional study of variant CRTH2 gene, and for genetic studies of asthma and other immunologic diseases.
authors.affiliation: Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224-6801, USA.
authors.forename: S-C
authors.initials: SC
authors.lastname: Hsu
authors.forename: L-C
authors.initials: LC
authors.lastname: Chen
authors.forename: M-L
authors.initials: ML
authors.lastname: Kuo
authors.forename: J-L
authors.initials: JL
authors.lastname: Huang
authors.forename: S-K
authors.initials: SK
authors.lastname: Huang
mesh_terms: D001483:Base Sequence; D002681:China; D005838:Genotype; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics*; D011982:Receptors, Prostaglandin
chemical_list: D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; C036293:prostaglandin D2 receptor