Activities of new fluoroquinolones, ketolides, and other antimicrobials against blood culture isolates of viridans group streptococci from across Canada, 2000.
The rates of nonsusceptibility to penicillin, erythromycin, and clindamycin of 191 blood culture isolates of viridans group streptococci collected from across Canada in 2000 were 36, 42, and 10%, respectively. Although 8% of the strains were resistant to ciprofloxacin (MIC >or= 4 microg/ml), the MICs of gemifloxacin, BMS 284756, telithromycin, and ABT 773 at which 90% of the strains were inhibited were 0.06, 0.06, 0.12, and 0.03 microg/ml, respectively.
Gershon
Andrea S
AS
University of Toronto, Toronto, Canada.
de Azavedo
Joyce C S
JC
McGeer
Allison
A
Ostrowska
Krystyna I
KI
Church
Deirdre
D
Hoban
Daryl J
DJ
Harding
Godfrey K M
GK
Weiss
Karl
K
Abbott
Lewis
L
Smaill
Fiona
F
Gourdeau
Marie
M
Murray
Gilles
G
Low
Donald E
DE
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D001769:Blood / Q000382:microbiology*; D002170:Canada; D003470:Culture Media; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones; D006801:Humans; D018942:Macrolides; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards; D013290:Streptococcal Infections / Q000382:microbiology*; D013291:Streptococcus / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D003470:Culture Media; D024841:Fluoroquinolones; D018942:Macrolides