The influence of the new benzodiazepine derivative BD-1158 on the behaviour of rabbits in spontaneous conditions.
BD-1158 is a new 1,4 benzodiazepine derivative. The purpose of the present experiments was to test the spontaneous behaviour (typical of a rabbit) after administration of BD-1158 and thus to define the activity and side effects of this substance under physiological conditions. The experiments were performed for 3 subsequent days in a group of 10 rabbits. On the first day spontaneous behaviour was tested. On the second day 1 ml of 1% starch solution was administered intraperitoneally. On the third day BD-1158 was administered intraperitoneally at a dose 10 mg/kg diluted in 1% starch solution up to 1 ml, 35-40 minutes before the beginning of the experiment. Six phases of behaviour were estimated. It was concluded that BD-1158 has a strong anxiolytic and sedative effect, decreases the state of animal's attention, water and food uptake.
Cygan
B
B
Department of Human Physiology, Medical University of Lublin.
Wójcik
G
G
Czabak-Garbacz
R
R
Teter
M
M
Kozlovsky
I
I
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001569:Benzodiazepines / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D008297:Male; D009949:Orientation / Q000187:drug effects; D011817:Rabbits
D014151:Anti-Anxiety Agents; C456819:BD-1158; D001569:Benzodiazepines