GAP-43 expression and pathological changes of temporal infarction in rats and effects of batroxobin.
To study the changes of the expression of growth-associated protein-43 (GAP-43) and pathology in temporal infarction of rats photochemically induced and the effects of batroxobin.


METHODS
Immunohistochemical technique and hematoxylin-eosin stain was used to show the changes of the expression of GAP-43 and pathology.


RESULTS
In infarction group, GAP-43 expression was markedly increased on the infarction and surrounding tissues at 24 h cerebral infarction. The expression reached peak level at 72 h after cerebral infarction and was decreased at 7 d after cerebral infarction. However, in batroxobin-treated group, GAP-43 expression was increased and the pathological changes were much slight as compared with infarction group.


CONCLUSIONS
The expression of GAP-43 increases in infarction of temporal neocortex and batroxobin promotes the expression of GAP-43 and ameliorates the pathological changes in infarction of temporal neocortex.
Wu
Weiping
W
Neurotransmitter Research Laboratory, Department of Neurology, Chinese PLA General Hospital, Postgraduate Military Medical School, Beijing 100853.
Guan
Xingzhi
X
Zhang
Xiaoshu
X
Kuang
Peigen
P
D000818:Animals; D012103:Batroxobin / Q000494:pharmacology*; D020520:Brain Infarction / Q000378:metabolism* / Q000473:pathology; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D019922:GAP-43 Protein / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D019579:Neocortex / Q000473:pathology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013702:Temporal Lobe / Q000473:pathology
D005343:Fibrinolytic Agents; D019922:GAP-43 Protein; D012103:Batroxobin