title: Naïve to memory T-cell differentiation during homeostasis-driven proliferation.
abstract: During homeostasis-driven T-cell proliferation, naïve T cells stably acquire the cell surface markers and functional properties of antigen-induced memory T cells. Thus, in T-cell-deficient individuals, homeostasis-driven T-cell proliferation appears to restore only the memory T-cell compartment, whereas the reconstitution of the naïve T-cell compartment depends on de novo T-cell development in the thymus.
authors.affiliation: Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, E17-128, 40 Ames Street, Cambridge, MA 02139, USA.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ge
authors.forename: Hui
authors.initials: H
authors.lastname: Hu
authors.forename: Herman N
authors.initials: HN
authors.lastname: Eisen
authors.forename: Jianzhu
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D006649:Histocompatibility Antigens / Q000276:immunology; D006706:Homeostasis; D007156:Immunologic Memory / Q000276:immunology*; D010641:Phenotype; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology*
chemical_list: D006649:Histocompatibility Antigens