IL12B polymorphism and type 1 diabetes in the Italian population: a case-control study.
A polymorphism in the interleukin 12B gene was recently reported to be strongly associated with type 1 diabetes in 422 Australian and British families. We analyzed the same polymorphism in 470 Italian type 1 diabetic patients and 544 matched control subjects and found no evidence of association with the disease.
Nisticò
Lorenza
L
Institute of Cell Biology, CNR, Campus Buzzati-Traverso, Monterotondo, Rome, Italy. lnistico@ibc.rm.cnr.it
Giorgi
Gabriele
G
Giordano
Mara
M
Galgani
Andrea
A
Petrone
Antonio
A
D'Alfonso
Sandra
S
Federici
Massimo
M
Di Mario
Umberto
U
Pozzilli
Paolo
P
Buzzetti
Raffaella
R
Cascino
Isabella
I
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics*; D007558:Italy / Q000453:epidemiology; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors
D018664:Interleukin-12