title: Oxime derivatives of sordaricin as potent antifungal agents.
abstract: Oxime derivatives of the sordarin aglycone have been identified as potent antifungal agents. The in vitro spectrum of activity includes coverage against Candida albicans and Candida glabrata with MICs as low as 0.06 microg/mL. The antifungal activity was established to be exquisitely sensitive to the spatial orientation of the lipophilic side chains.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. michael.serrano-wu@bms.com
authors.forename: Michael H
authors.initials: MH
authors.lastname: Serrano-Wu
authors.forename: Denis R
authors.initials: DR
authors.lastname: St  Laurent
authors.forename: Charles E
authors.initials: CE
authors.lastname: Mazzucco
authors.forename: Terry M
authors.initials: TM
authors.lastname: Stickle
authors.forename: John F
authors.initials: JF
authors.lastname: Barrett
authors.forename: Dolatrai M
authors.initials: DM
authors.lastname: Vyas
authors.forename: Balu N
authors.initials: BN
authors.lastname: Balasubramanian
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D004224:Diterpenes; D057927:Hydrophobic and Hydrophilic Interactions; D008826:Microbial Sensitivity Tests; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D004224:Diterpenes; D010091:Oximes; C116705:sordaricin