title: Rheumatoid syndrome associated with lung interstitial disorder in a dental technician exposed to ceramic silica dust. A case report and critical literature review.
abstract: Exposure to silica minerals is associated with silicosis and autoimmune disorders, especially systemic scleroderma. Evidence of this association has been increasingly reported in the last decade. The aim of this paper is to discuss, on the basis of a literature review, the case of a 28-year-old female dental technician who suffered from episodes of weakness, arthralgia, pain, swelling and stiffness of the fingers, dyspnoea with cough, a positive Waaler-Rose reaction, increased rheumatoid factor and normal ESR. She was a non-smoker. A rheumatoid syndrome with lung interstitial disorder, associated with silica exposure from dental ceramic products, was diagnosed. The patient had the HLA-A2-A31, HLA-B51-B18 and HLA-DR3-DR11 haplotypes, some of which are associated with autoimmune disease susceptibility. A 6-month follow-up, with adequate protection and without treatment, showed disappearance of the symptomatology and negative tests for Waaler-Rose reaction and rheumatoid factor. Exposure to silica should, therefore, be sought in the history of any patient with autoimmune or lupus-like syndrome and pulmonary changes. Symptoms associated with silica dust exposure from dental ceramic products should be recognised as being due potentially to an occupational disease, and dental technicians should be protected as workers at risk.
authors.affiliation: University of Catania Medical School, Ospedale Garibaldi, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Iannello
authors.forename: M
authors.initials: M
authors.lastname: Camuto
authors.forename: S
authors.initials: S
authors.lastname: Cantarella
authors.forename: A
authors.initials: A
authors.lastname: Cavaleri
authors.forename: P
authors.initials: P
authors.lastname: Ferriero
authors.forename: A
authors.initials: A
authors.lastname: Leanza
authors.forename: P
authors.initials: P
authors.lastname: Milazzo
authors.forename: F
authors.initials: F
authors.lastname: Belfiore
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000139:chemically induced*; D002516:Ceramics / Q000009:adverse effects*; D003800:Dental Technicians; D004391:Dust / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging; D016273:Occupational Exposure; D013902:Radiography, Thoracic; D012822:Silicon Dioxide / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D004391:Dust; D012822:Silicon Dioxide