The kinetics of methaemoglobin substitution reactions have been investigated by the stopped-flow technique. Biphasic reactions have been observed with adult and fetal methaemoglobin. This behaviour is attributed to different reactivities of the chain types. The investigations give evidence of an increasing chain reactivity in the sequence alpha-chain < beta-chain < gamma-chain. The differences increase with the size of the substituting ligand, indicating steric effects.
Blanck
J
J
Institut für Pharmakologie und Toxikologie der Universität, Greifswald, DDR
Scheler
W
W