[Polymorphism of microsatellite markers D6S296, etc. in patients with schizophrenia].
OBJECTIVE
To investigate the loci associated with susceptibility to schizophrenia in the human chromosome 6.


METHODS
Genomic DNA was isolated from the blood samples of 178 schizophrenia patients in Shanghai, including 82 chronic schizophrenics with a course of more than 10 years, and 88 healthy persons as controls. Amplified fragment length polymorphism (AFLP) technique was used to investigate the polymorphism of the four microsatellite markers: D6S470, D6S274, D6S296, and D9S175.


RESULTS
The distribution of the allele frequencies in these four microsatellite markers conformed to Hardy-Weinberg equilibrum. The gene frequency of the allele 264 bp of D6S296 was 0.1688 in chronic schizophrenics, and was 0.039 0 in healthy persons (chi(2) = 17.68, P < 0.001). The gene frequencies of other alleles did not differ between the schizophrenics and controls. There was a very strong association between chronic schozophrenia and the allele 264 bp of D6S296 (RR = 8.30, chi(2) = 17.68, upsilon = 1, P < 0.001).


CONCLUSIONS
Gene(s) associated with susceptibility to schizophrania may exist in the microsatellite marker region D6S296 in the chromosome 6.
Zhang
Xianning
X
Department of Genetics, School of Medicine, Ningbo University, Ningbo 315211, China.
Jiang
Sanduo
S
Le
Yanping
Y
Qian
Yiping
Y
Wang
Dongxiang
D
D000328:Adult; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*
D005819:Genetic Markers