Two new furanoditerpenes from Saururus chinenesis and their effects on the activation of peroxisome proliferator-activated receptor gamma.
Two new acyclic furanoditerpene compounds, saurufuran A (1) and B (2), were obtained from the root of Saururus chinensis, and their structures were elucidated by means of 1D and 2D NMR spectroscopic analyses. Saurufuran A (1) is effective on the activation of peroxisome proliferator-activated receptor gamma (PPARgamma) with an EC(50) value of 16.7 microM; however, saurufuran B (2), with an EC(50) value of >100 microM, weakly activated the PPARgamma.
Hwang
Bang Yeon
BY
Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
Lee
Jeong-Hyung
JH
Nam
Jeong Bum
JB
Kim
Hang Sub
HS
Hong
Young Soo
YS
Lee
Jung Joon
JJ
D016475:3T3 Cells / Q000187:drug effects; D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007723:Korea; D008024:Ligands; D008156:Luciferases / Q000378:metabolism; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D014157:Transcription Factors / Q000819:agonists*; D014162:Transfection; D001616:beta-Galactosidase / Q000378:metabolism
D004224:Diterpenes; D005663:Furans; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C457251:saurufuran A; C457252:saurufuran B; D008156:Luciferases; D001616:beta-Galactosidase