title: [A case of fluvoxamine overdose].
abstract: Selective serotonin reuptake inhibitors (SSRI) are newly developed-antidepressants authorized in 1999 in Japan. We experienced a case of drug poisoning including fluvoxamine, one of SSRI. A comatose nineteen-year-old girl was transported to our ER in the morning on July 25, 2000. There remained many empty packages of fluvoxamine and several sorts of tranquilizers in the room. Her consciousness became alert over the next morning. HPLC analysis revealed fluvoxamine, chlorpromazine, promethazine, biperiden, phenobarbital, and zopiclone in her blood and that serum concentrations of the first three were above the therapeutic ranges. The peak values of fluvoxamine, chlorpromazine, and promethazine were 1,343 ng/ml (6.7 times of the upper limit), 861 ng/ml (2 times), and 529 ng/ml (1.3 times), respectively. Fluvoxamine must be a main cause of her toxic symptoms although other CNS-depressing drugs might work jointly.
authors.affiliation: Department of Emergency Medicine & Trauma Surgery, Ehime University Hospital.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Oka
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Shirakawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Koyama
authors.forename: Soichi
authors.initials: S
authors.lastname: Maekawa
authors.forename: Masami
authors.initials: M
authors.lastname: Hirota
authors.forename: Osamu
authors.initials: O
authors.lastname: Nishizaki
authors.forename: Shinya
authors.initials: S
authors.lastname: Fukumoto
authors.forename: Genro
authors.initials: G
authors.lastname: Ochi
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000097:blood / Q000506:poisoning*; D002851:Chromatography, High Pressure Liquid; D062787:Drug Overdose; D005260:Female; D016666:Fluvoxamine / Q000097:blood / Q000506:poisoning*; D006801:Humans; D017367:Selective Serotonin Reuptake Inhibitors / Q000097:blood / Q000506:poisoning*; D013997:Time Factors; D014149:Tranquilizing Agents / Q000097:blood / Q000506:poisoning
chemical_list: D000928:Antidepressive Agents; D016666:Fluvoxamine; D017367:Selective Serotonin Reuptake Inhibitors; D014149:Tranquilizing Agents