[The effect of L-Glutamine and Shakuyaku-Kanzo-to for paclitaxel-induced myalgia/arthralgia].
Myalgia/arthralgia is a crucial side effect of paclitaxel, and may become the major dose-limiting side effect. However, this is a situation where there is little effective preventive treatment. L-Glutamine was reported as a neuroprotective agent for vincristine-induced neurotoxicity. In Japan, there have been reports on steroid and Shakuyaku-Kanzou-to (a herbal medicine) for paclitaxel-induced myalgia/arthralgia. This study aimed to compare the effect of L-Glutamine and Shakuyaku-Kanzou-to, and to discuss the validity of these agents for the paclitaxel-induced myalgia/arthralgia. Our results suggested that Shakuyaku-Kanzou-to showed no remarkable effects against paclitaxel-induced myalgia/arthralgia as had been reported before; however, both L-Glutamine and Shakuyaku-Kanzou-to decreased the duration of grade 2 toxicity (CALGB Expanded Common Toxicity Criteria) in comparison with those who were not treated. L-Glutamine and Shakuyaku-Kanzou-to might therefore a preventive effect against moderate or severer myalgia/arthralgia during paclitaxel-treated chemotherapy. Further trials are needed to confirm the value of these drugs.
Hasegawa
Kosei
K
Dept. of Obstetrics and Gynecology, Okayama University Medical School.
Mizutani
Yasushi
Y
Kuramoto
Hiroyuki
H
Nagao
Shoji
S
Masuyama
Hisashi
H
Hongo
Atsuhi
A
Kodama
Jyunichi
J
Yoshinouchi
Mitsuo
M
Hiramatsu
Yuji
Y
Kudo
Takafumi
T
Okuda
Hiroyuki
H
D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D018771:Arthralgia / Q000139:chemically induced / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005973:Glutamine / Q000627:therapeutic use*; D006035:Glycyrrhiza; D006801:Humans; D018482:Muscle, Skeletal; D009369:Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000009:adverse effects*; D029596:Paeonia; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D011788:Quality of Life
D000972:Antineoplastic Agents, Phytogenic; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C038462:shakuyaku-kanzoh-toh; D005973:Glutamine; D017239:Paclitaxel