title: [Level of plasma lysophosphatidic acid in patients with cerebral ischemic attack, a preliminary study].
abstract: OBJECTIVE
  To study the level of plasma lysophosphatidic acid (LPA) in patients with TIA, cerebral thrombosis or possible ischemic attack.
  
  
  METHODS
  Phospholipid was extracted from plasma of patients with TIA, cerebral thrombosis or possible ischemic attack by organic solvent. Lysophosphatidic acid was isolated further. The quantity of LPA was determined by assaying its phosphorous component.
  
  
  RESULTS
  LPA level of patients with TIA, cerebral thrombosis or possible ischemic attack were 2.14 +/- 1.02, 1.50 +/- 0.85, and 1.73 +/- 1.14 micromol/L blood plasma respectively, all significantly higher than that in control group (1.00 +/- 0.70 micromol/L, P < 0.05). The plasma LPA level decreased after anticoagulant treatment.
  
  
  CONCLUSIONS
  As a molecular marker released by activated platelets in vivo, plasma PLA may be valuable in diagnosis of cerebral ischemic attack.
authors.affiliation: Department of Neurology, Beijing Ji Shui Tan Hospital, Beijing Capital Medical Unimversity, Beijing 100035, China.
authors.forename: Yuheng
authors.initials: Y
authors.lastname: Sun
authors.forename: Qizhuan
authors.initials: Q
authors.lastname: Wu
authors.forename: Cunshan
authors.initials: C
authors.lastname: Yao
authors.forename: Shichang
authors.initials: S
authors.lastname: Huang
authors.forename: Zhaoshu
authors.initials: Z
authors.lastname: Tang
authors.forename: Zhenguang
authors.initials: Z
authors.lastname: Li
authors.forename: Heqiu
authors.initials: H
authors.lastname: Bao
authors.forename: Song
authors.initials: S
authors.lastname: Li
authors.forename: Weijin
authors.initials: W
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood*; D008246:Lysophospholipids / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D008246:Lysophospholipids