title: Novel AT(1) receptor-independent functions of losartan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Sadoshima
mesh_terms: D057911:Angiotensin Receptor Antagonists; D000893:Anti-Inflammatory Agents / Q000378:metabolism / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001711:Biotransformation; D051546:Cyclooxygenase 2; D006801:Humans; D054755:Imidazoline Receptors; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D019808:Losartan / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D008565:Membrane Proteins; D009206:Myocardium / Q000378:metabolism; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism / Q000494:pharmacology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin / Q000378:metabolism*; D011955:Receptors, Drug / Q000037:antagonists & inhibitors; D018039:Receptors, Tachykinin / Q000037:antagonists & inhibitors; D017482:Receptors, Thromboxane / Q000037:antagonists & inhibitors; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D057911:Angiotensin Receptor Antagonists; D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D054755:Imidazoline Receptors; D007527:Isoenzymes; D008565:Membrane Proteins; D010975:Platelet Aggregation Inhibitors; D011453:Prostaglandins; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin; D011955:Receptors, Drug; D018039:Receptors, Tachykinin; D017482:Receptors, Thromboxane; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D019808:Losartan