Effect of distamycin a on the structure and template activity of DNA in RNA - polymerase system.
It is shown that native and denatured DNA form complexes with the oligopeptide-antibiotic distamycin A. The pronounced inhibition of the incorporation of AMP into RNA in the DNA directed RNA-polymerase system is due to the interference of the antibiotic with DNA.
Chandra
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Institut für Therapeutische Biochemie der Universität, Frankfurt an Main, GDR
Zimmer
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C
Thrum
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