title: Chiral synthesis and enzymatic resolution of (S)-(-)piperazine-2-carboxylic acid using enzyme alcalase.
abstract: Enantiomerically pure (S)-piperazine-2-carboxylic acid was synthesized by kinetic resolution of methyl-4-(tert-butyroxycarbonyl)-piperazine-2-carboxylate using a low cost enzyme alcalase.
authors.affiliation: ChemPacific Corporation, Baltimore, Maryland, USA.
authors.forename: G
authors.initials: G
authors.lastname: Wu
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.forename: R G
authors.initials: RG
authors.lastname: Luo
authors.forename: D
authors.initials: D
authors.lastname: Wei
authors.forename: S V
authors.initials: SV
authors.lastname: Malhotra
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D010879:Piperazines / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013381:Subtilisins / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D010879:Piperazines; C453680:piperazine-2-carboxylic acid; D013381:Subtilisins