title: Chronaxie and accommodation index in the diagnosis of muscle denervation.
abstract: OBJECTIVE
  To determine the sensitivity of the combined measurement of chronaxie and the accommodation index in the qualitative diagnosis of muscle denervation with needle electromyography and to compare quantitative diagnoses.
  
  
  METHODS
  Ninety-three neurogenic muscles diagnosed by needle electromyography were consecutively included for measurement of chronaxie and the accommodation index in this prospective study. The sensitivity of qualitative diagnosis was assessed for all muscles, separately for the acute and subacute-chronic denervation phase and for the complete and partial denervation.
  
  
  RESULTS
  The combined measurement of chronaxie and the accommodation index showed a 90% sensitivity to needle electromyography for qualitative diagnosis of muscle denervation for all muscles. A 100% sensitivity was found for the acute denervation phase and for complete denervation. The subacute-chronic denervation phase revealed a 86% sensitivity, and partial denervation had a 88% sensitivity. The kappa coefficients did not show satisfactory agreement in quantitative diagnosis, and Bowker's test revealed a statistically significant underestimation of muscle denervation for measurement of chronaxie.
  
  
  CONCLUSIONS
  The combined measurement of chronaxie and the accommodation index can be recommended for the screening of neurogenic lesions in the acute denervation phase.
authors.affiliation: Department of Physical Medicine, University of Vienna, Austria.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Paternostro-Sluga
authors.forename: Othmar
authors.initials: O
authors.lastname: Schuhfried
authors.forename: Gerda
authors.initials: G
authors.lastname: Vacariu
authors.forename: Thomas
authors.initials: T
authors.lastname: Lang
authors.forename: Veronika
authors.initials: V
authors.lastname: Fialka-Moser
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002907:Chronaxy; D002908:Chronic Disease; D004576:Electromyography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000175:diagnosis*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric