title: Intragenic breakpoint within RAD51L1 in a t(6;14)(p21.3;q24) of a pulmonary chondroid hamartoma.
abstract: Rearrangements involving chromosome region 14q23-->q24 represent a main cytogenetic subgroup in a variety of benign solid tumors. Recently, in uterine leiomyomas containing the classical t(12;14)(q15;q23-->q24), the primary chromosome 14 target gene was identified as the protein kinase-encoding gene RAD51L1. In this report we show that RAD51L1 is also involved in the frequently occurring t(6;14) (p21;q23-->q24) in pulmonary chondroid hamartomas.
authors.affiliation: Center for Human Genetics, University of Bremen, Bremen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Blank
authors.forename: E F
authors.initials: EF
authors.lastname: Schoenmakers
authors.forename: P
authors.initials: P
authors.lastname: Rogalla
authors.forename: E H
authors.initials: EH
authors.lastname: Huys
authors.forename: A A
authors.initials: AA
authors.lastname: van Rijk
authors.forename: N
authors.initials: N
authors.lastname: Drieschner
authors.forename: J
authors.initials: J
authors.lastname: Bullerdiek
mesh_terms: D019457:Chromosome Breakage / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005091:Exons / Q000235:genetics; D006222:Hamartoma / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008171:Lung Diseases / Q000235:genetics*; D020161:Physical Chromosome Mapping; D051135:Rad51 Recombinase; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C495153:RAD51 protein, human; D051135:Rad51 Recombinase