title: Regioselective O-substitution of p-tert-butylcalix[7]arene.
abstract: [structure: see text]. The first examples of selectively functionalized calix[7]arenes have been obtained by weak-base promoted O-alkylation or O-benzoylation of p-tert-butylcalix[7]arene. Mono-, 1,3- and 1,4-disubstituted calix[7]arenes have been obtained in workable yields, while the 1,2,4,6-tetrasubstitution was achieved with surprisingly high selectivity (50-88% yield) by using K2CO3 as base. A rationale for this finding is proposed.
authors.affiliation: Dipartimento di Chimica, Università di Salerno, Via S. Allende 43, I-84081 Baronissi, SA, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Martino
authors.forename: Luisa
authors.initials: L
authors.lastname: Gregoli
authors.forename: Carmine
authors.initials: C
authors.lastname: Gaeta
authors.forename: Placido
authors.initials: P
authors.lastname: Neri