Effect of clarithromycin on chronic respiratory infection caused by Pseudomonas aeruginosa with biofilm formation in an experimental murine model.
Fourteen-membered macrolides (e.g. clarithromycin and erythromycin), but not 16-membered macrolides (e.g. josamycin), are effective in diffuse panbronchiolitis. However, there are no studies that have compared the effects of 14- and 16-membered macrolide antibiotics on biofilm formation. Treatment with high-dose clarithromycin (100 mg/kg) resulted in a significant decrease in the number of viable bacteria in an experimental murine model. Josamycin at a dose of up to 100 mg/kg had no effect on the number of viable bacteria in the lung. Our results may explain, at least in part, the clinical efficacy of 14-membered macrolide antibiotics in patients with chronic pneumonia caused by Pseudomonas aeruginosa.
Yanagihara
Katsunori
K
The Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852, Japan. kyana-ngs@umin.ac.jp
Tomono
Kazunori
K
Imamura
Yoshifumi
Y
Kaneko
Yukihiro
Y
Kuroki
Misuzu
M
Sawai
Toyomitsu
T
Miyazaki
Yoshitsugu
Y
Hirakata
Yoichi
Y
Mukae
Hiroshi
H
Kadota
Jun-Ichi
J
Kohno
Shigeru
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D018441:Biofilms / Q000187:drug effects*; D002908:Chronic Disease; D017291:Clarithromycin / Q000627:therapeutic use*; D015570:Josamycin / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology*; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D017291:Clarithromycin; D015570:Josamycin