title: Mexiletine related chronic defibrillation threshold elevation: case report and review of the literature.
abstract: Many antiarrhythmic drugs may produce a rise in defibrillation threshold. Mexiletine is a frequently used antiarrhythmic drug in patients with an implantable cardioverter defibrillator, usually thought of as producing no or minimal effects on the defibrillation threshold. The current case report presents a patient with an endocardial implantable cardioverter defibrillator being treated with mexiletine, which precluded the ability to defibrillate the patient.
authors: Cardiology Department, Cardiac Research Center, Soroka University Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
authors: Eugene
authors: E
authors: Crystal
authors: I Eli
authors: IE
authors: Ovsyshcher
authors: Alan B
authors: AB
authors: Wagshal
authors: Amos
authors: A
authors: Katz
authors: Reuven
authors: R
authors: Ilia
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002311:Cardiomyopathy, Dilated / Q000628:therapy*; D004868:Equipment Failure; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000009:adverse effects* / Q000627:therapeutic use; D013614:Tachycardia, Paroxysmal / Q000628:therapy*
chemical_list: D000889:Anti-Arrhythmia Agents; D008801:Mexiletine