A role for APP in motility and transcription?
Recent studies suggest two novel roles for the amyloid precursor protein (APP): APP accelerates wound healing in MDCK cells and acts in a notch-like manner to activate transcription. Both of these putative functions are dependent on the interaction of APP with the APP-binding protein FE65. Future studies are required to understand the full implications of these new findings and to determine whether therapeutic strategies for Alzheimer's disease should take these putative functions into account.
Guénette
Suzanne Y
SY
Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129-4404, USA. guenette@helix.mgh.harvard.edu
D016564:Amyloid beta-Protein Precursor / Q000502:physiology*; D000818:Animals; D004285:Dogs; D006801:Humans; D009419:Nerve Tissue Proteins / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology; D014158:Transcription, Genetic; D014945:Wound Healing
C091042:APBB1 protein, human; D016564:Amyloid beta-Protein Precursor; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins