Hepatitis associated with Chinese herbs.
Traditional Chinese herbal medicines are widely available in Western society and are popular as a form of 'natural' alternative medicine. Their use is increasing, as they are perceived to be free of side effects, but they remain largely unregulated. We describe two patients who suffered severe hepatitis, one of whom died, after taking Chinese herbal remedies for minor complaints. We also review the English-language literature on hepatitis associated with Chinese herbs. Two products appear to be implicated frequently: Jin bu huan was taken by 11 patients, and Dictamnus dasycarpus was taken by six patients, including both fatal cases. It is difficult to provide conclusive evidence of what caused hepatitis, as these products are mixtures that may contain adulterants. These cases highlight not only the potential dangers of these products to consumers but also the need for greater control of their manufacture and use.
McRae
C A
CA
Freeman Hospital Liver Unit, Newcastle upon Tyne Hospitals Trust, Newcastle, UK.
Agarwal
K
K
Mutimer
D
D
Bassendine
M F
MF
D000328:Adult; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use; D018771:Arthralgia / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008068:Lipomatosis / Q000188:drug therapy; D008297:Male
D000700:Analgesics; D004365:Drugs, Chinese Herbal; C086355:jin bu huan