Regulation of experimental autoimmune encephalomyelitis by chemokines and chemokine receptors.
Experimental autoimmune encephalomyelitis (EAE) is a T cell mediated demyelinating disease of the central nervous system (CNS) that serves as a model for multiple sclerosis (MS). Insights into the pathogenesis of this model may help scientists understand the human disease and aid in rational drug discovery. In this review we summarize the role of chemokines and chemokine receptors in disease pathogenesis and suggest a pathway of events that leads to demyelination and subsequent clinical disease manifestation.
Elhofy
Adam
A
Department of Pathology, Northwestern University Medical School, Chicago, IL 60611, USA.
Kennedy
Kevin J
KJ
Fife
Brian T
BT
Karpus
William J
WJ
D000818:Animals; D018925:Chemokines / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology; D006801:Humans; D019707:Receptors, Chemokine / Q000276:immunology*
D018925:Chemokines; D019707:Receptors, Chemokine