title: [Antiphospholipid syndrome with only antiphosphatidylethanolamine antibodies: report of 20 cases].
abstract: OBJECTIVE
  The association of antiphosphatidylethanolamine antibodies (aPE) as the only antiphospholipid antibody with antiphospholipid syndrome (APS) is discussed. The aPE was described as the sole antibody in many cases suggesting APS. aPE was not included in the Sapporo criteria for the classification of APS.
  
  
  METHODS
  We investigated the clinical features of 20 patients with aPE only; 17 patients had symptoms potentially related to APS (group 1) and three had other manifestations (group 2).
  
  
  RESULTS
  There were 15 women and five men, mean age was 35 +/- 12 years at the beginning. In group 1 (n = 17), ten patients presented arterial thrombosis, nine venous thrombosis (five had both), and six microvascular thrombosis (livedo reticularis, lacunar pathology). The aPE positivity was persistent in 13 patients. A subgroup of four patients (three women) presented arteriosclerosis with peripheral arteriopathy which started before 45 years of age. They had another atherosclerosis risk factor associated with aPE persistence. In group 2 (n = 3), there was no thrombotic event, one demyelinating pathology, one microvascular pathology, and one arterial dysplasia. The aPE positivity was never confirmed. Finally, 13 patients presented an APS with aPE only, confirmed at least 8 weeks later.
  
  
  CONCLUSIONS
  Our study points out that testing for aPE would be of interest for patients when symptoms were potentially related to APS, particularly when other antiphospholipid antibodies were negative. This description questions the enlargement of the APS biological criteria defined in Sapporo. The role of aPE in atherosclerosis is considered.
authors: Service de médecine interne, hôpital Claude-Huriez, CHRU, 59037 Lille, France. c.desauw@free.fr
authors: C
authors: C
authors: Desauw
authors: E
authors: E
authors: Hachulla
authors: Y
authors: Y
authors: Boumbar
authors: J
authors: J
authors: Bouroz-Joly
authors: D
authors: D
authors: Ponard
authors: J
authors: J
authors: Arvieux
authors: S
authors: S
authors: Dubucquoi
authors: A L
authors: AL
authors: Fauchais
authors: P Y
authors: PY
authors: Hatron
authors: B
authors: B
authors: Devulder
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000032:analysis*; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000276:immunology / Q000473:pathology*; D001161:Arteriosclerosis / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D013927:Thrombosis / Q000209:etiology
chemical_list: D017152:Antibodies, Antiphospholipid