title: Synthesis of ribosomal proteins in developing Dictyostelium discoideum cells is controlled by the methylation of proteins S24 and S31.
abstract: Ribosomal protein mRNAs left over from growth are selectively excluded from polyribosomes in the first half of Dictyostelium discoideum development. This is due to the fact that they are sequestered by a class of free 40S ribosomal subunits, characterized by possessing a methylated S24 protein. At the time of formation of tight cell aggregates, the methylated S24 is substituted by an unmethylated S24, while protein S31 of the same or other 40S subunits becomes methylated. This leads to a rapid degradation of the ribosomal protein mRNAs.
authors: Dipartimento di Fisiopatologia Clinica, Torino, Italy.
authors: Giorgio
authors: G
authors: Mangiarotti
mesh_terms: D000814:Aniline Compounds; D000818:Animals; D001345:Autoradiography; D015152:Blotting, Northern; D002498:Centrifugation; D004247:DNA / Q000235:genetics; D004023:Dictyostelium / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D015180:Electrophoresis, Gel, Two-Dimensional; D008745:Methylation; D011132:Polyribosomes / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012335:RNA, Ribosomal / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D012269:Ribosomal Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism*
chemical_list: D000814:Aniline Compounds; D012333:RNA, Messenger; D012335:RNA, Ribosomal; D012269:Ribosomal Proteins; C059034:ribosomal protein S31, Dictyostelium discoideum; C487557:4-trifluoromethylaniline; D004247:DNA