The prognostic significance of trisomy 8 in patients with acute myeloid leukemia.
Recent therapeutic outcomes for patients with acute myeloid leukemia and trisomy 8 (+8) who were seen at our institution were investigated. Complete remission was achieved in 85% with isolated +8, 100% with +8 and chromosomal abnormalities predictive of a favorable outcome, and 47% of patients with +8 and other, mostly complex chromosomal abnormalities. Median relapse-free and overall survivals in months were 5.5 and 12 (isolated +8), 20 and 25 (+8 and favorable karyotype), and 7.5 and 6 (+8 and unfavorable karyotype). Despite an encouraging rate of complete remission, the relapse-free and overall survivals for patients with isolated +8 were not significantly different from those of patients with +8 and unfavorable karyotypes. The presence of +8 did not appear to adversely affect the outcome of patients with favorable karyotypes.
Elliott
Michelle A
MA
Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Letendre
Louis
L
Hanson
Curtis A
CA
Tefferi
Ayalew
A
Dewald
Gordon W
GW
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002898:Chromosomes, Human, Pair 8; D018572:Disease-Free Survival; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D008875:Middle Aged; D011379:Prognosis; D012074:Remission Induction; D015996:Survival Rate; D016896:Treatment Outcome; D014314:Trisomy