Platelet activation after in vitro contact with seven acrylic bone cements.
Seven acrylic bone cements were evaluated: Cemex Rx (Tecres S.p.a., Italy), Cemex Isoplastic (Tecres S.p.a., Italy), Zimmer Low Viscosity Cement (L.V.C., Zimmer, IN, USA), Zimmer bone cement - dough type (Zimmer, IN, USA), CMW (DePuy International Ltd., UK), Cerim LT (Cremascoli S.r.l., Italy), and Palacos (Merck, Wehreim, Germany). The cements after polymerization were put in contact in vitro with platelet-rich plasma. Plasma in contact only with siliconated glass was used as the negative control. After contact, platelet number, beta-thromboglobulin (beta-TG), and transforming growth factor-beta1 (TGF-beta1) were determined. The Wilcoxon signed rank test showed Palacos R and L.V.C. induced a significant decrease of platelet number compared with the negative control. All cements determined a significant increase in beta-TG. CMW 3, Palacos, L.V.C., and Zimmer dough type determined a significant increase in TGF-beta1 compared with the negative control.
Cenni
E
E
Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy. elisabetta.cenni@ior.it
Granchi
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D
Pizzoferrato
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A
D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism; D001843:Bone Cements / Q000737:chemistry / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020366:Methylmethacrylate / Q000737:chemistry / Q000494:pharmacology; D015539:Platelet Activation; D019904:Polymethyl Methacrylate / Q000737:chemistry / Q000494:pharmacology; D012825:Silicon / Q000737:chemistry; D016212:Transforming Growth Factor beta / Q000378:metabolism; D053773:Transforming Growth Factor beta1; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology; D001620:beta-Thromboglobulin / Q000494:pharmacology
D001672:Biocompatible Materials; D001843:Bone Cements; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D014665:Vasodilator Agents; D001620:beta-Thromboglobulin; D020366:Methylmethacrylate; D019904:Polymethyl Methacrylate; D012825:Silicon