Estimation of concentrations of antifungal agents allowed as food additives in foods and their daily intake based on official inspection results in Japan in fiscal year 1998.
The mean concentrations and daily intake of four antifungal agents were estimated based on the results of an analysis of 7,005 samples of food obtained in official inspections by Japanese local governments in fiscal year 1998. The mean concentration of diphenyl was 0.0004% of the allowable limit, and those of imazalil, o-phenylphenol, and thiabendazole were 14.0%, 3.5%, and 5.7%, respectively. The daily intakes of these antifungal agents per person, estimated from their concentrations and the daily consumption of the foods, were 0.000326, 1.89, 11.5, and 23.3 micrograms, respectively, and assuming a body weight of 50 kg, the amounts of these antifungal agents consumed were 0.000013%, 0.15%, 0.12%, and 0.47% of the acceptable daily intake, respectively. These values are similar to the values obtained on the basis of the results of the official inspection in fiscal years 1994 and 1996, except that the amount of diphenyl is much lower (1/100).
Ishiwata
Hajimu
H
National Institute of Health Sciences: 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Abe
Yukiko
Y
Kubota
Hiroki
H
Kawasaki
Yoko
Y
Takeda
Yuiko
Y
Maitani
Tamio
T
Nishijima
Motohiro
M
Fukasawa
Yoshinobu
Y
D000935:Antifungal Agents / Q000032:analysis*; D005503:Food Additives / Q000032:analysis*; D005504:Food Analysis; D006801:Humans; D007564:Japan; D008452:Maximum Allowable Concentration
D000935:Antifungal Agents; D005503:Food Additives