Excess mortality associated with antimicrobial drug-resistant Salmonella typhimurium.
In a matched cohort study, we determined the death rates associated with drug resistance in Salmonella Typhimurium. We linked data from the Danish Surveillance Registry for Enteric Pathogens with the Civil Registration System and the Danish National Discharge Registry. By survival analysis, the 2-year death rates were compared with a matched sample of the general Danish population, after the data were adjusted for differences in comorbidity. In 2,047 patients with S. Typhimurium, 59 deaths were identified. Patients with pansusceptible strains of S. Typhimurium were 2.3 times more likely to die 2 years after infection than persons in the general Danish population. Patients infected with strains resistant to ampicillin, chloramphenicol, streptomycin, sulfonamide, and tetracycline were 4.8 times (95% CI 2.2 to 10.2) more likely to die, whereas quinolone resistance was associated with a mortality rate 10.3 times higher than the general population.
Helms
Morten
M
Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark.
Vastrup
Pernille
P
Gerner-Smidt
Peter
P
Mølbak
Kåre
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001434:Bacteriophage Typing; D003718:Denmark; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012307:Risk Factors; D012480:Salmonella Infections / Q000453:epidemiology / Q000382:microbiology* / Q000401:mortality*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology*; D015996:Survival Rate
D000900:Anti-Bacterial Agents