Hepatitis C: a critical analysis of therapeutic response predictors.
Treatment of chronic hepatitis C is still unspecific. However, there is great expectancy concerning the new pegylated interferons. As there has been much controversy about the best parameters to determine whether treatment is effective, we analyzed several criteria currently used for evaluation, including serum alanine aminotransferase (ALT) normalization, viral load reduction and improvement of hepatic histology.
Focaccia
R
R
Emílio Ribas Infectious Diseases Institute, São Paulo, SP, Brazil. focaccia@uol.com.br
Siciliano
R F
RF
Santos
E D B
ED
Boccardo
E
E
Conceição
O J G
OJ
Barbosa
U O
UO
Galante
V C
VC
D000410:Alanine Transaminase / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use; D004341:Drug Evaluation / Q000379:methods* / Q000592:standards*; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D008099:Liver / Q000473:pathology / Q000821:virology; D019562:Viral Load
D000998:Antiviral Agents; D007372:Interferons; D000410:Alanine Transaminase