Inhibition of vascular endothelial growth factor expression and production by triptolide.
Triptolide, the major component of the diterpenoids of the Chinese herb Tripterygium wilfordii Hook f. (Celastraceae), inhibited vascular endothelial growth factor expression and secretion in endothelial cells treated by 12-O-tetradecanoylphorbol 13-acetate dose-dependently. This effect may be one of the mechanisms underlying the therapeutic effects of triptolide on rheumatoid arthritis.
Hu
Ke-Bin
KB
Liu
Zhi-Hong
ZH
Liu
Dong
D
Li
Lei-Shi
LS
D029753:Celastraceae; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D016228:Endothelial Growth Factors / Q000235:genetics / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004852:Epoxy Compounds; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008222:Lymphokines / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D010616:Phenanthrenes; D010936:Plant Extracts / Q000494:pharmacology; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D004224:Diterpenes; D016228:Endothelial Growth Factors; D004852:Epoxy Compounds; D008222:Lymphokines; D010616:Phenanthrenes; D010936:Plant Extracts; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; C001899:triptolide; D013755:Tetradecanoylphorbol Acetate