Integration of calcium and Ras signalling.
Calcium is a universal intracellular signal that is responsible for controlling a plethora of cellular processes. Understanding how such a simple ion can regulate so many diverse cellular processes is a key goal of calcium- and cell-biologists. One molecule that is sensitive to changes in intracellular calcium levels is Ras. This small GTPase operates as a binary molecular switch, and regulates cell proliferation and differentiation. Here, we focus on examining the link between calcium and Ras signalling and, in particular, we speculate as to how the complexity of calcium signalling could regulate Ras activity.
Cullen
Peter J
PJ
The Henry Wellcome Laboratories for Integrated Cell Signalling, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK. Pete.Cullen@bris.ac.uk
Lockyer
Peter J
PJ
D002118:Calcium / Q000502:physiology*; D020935:MAP Kinase Signaling System / Q000502:physiology; D009474:Neurons / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D020664:Son of Sevenless Proteins / Q000502:physiology; D020703:ras GTPase-Activating Proteins / Q000502:physiology; D020663:ras Guanine Nucleotide Exchange Factors / Q000502:physiology; D018631:ras Proteins / Q000502:physiology*; D020666:ras-GRF1 / Q000502:physiology
D020664:Son of Sevenless Proteins; D020703:ras GTPase-Activating Proteins; D020663:ras Guanine Nucleotide Exchange Factors; D020666:ras-GRF1; D018631:ras Proteins; D002118:Calcium