title: Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors.
abstract: Using simple, inexpensive equipment, we have used solution-phase parallel synthesis to rapidly prepare hundreds of sulfonamide- and urea-containing FKBP inhibitors, resulting in rapid identification of extremely potent compounds in these series.
authors: Guilford Pharmaceuticals Inc., Research Department, 6611 Tributary Street, Baltimore, MD 21224, USA.
authors: Chi
authors: C
authors: Choi
authors: Jia-He
authors: JH
authors: Li
authors: Mark
authors: M
authors: Vaal
authors: Christine
authors: C
authors: Thomas
authors: David
authors: D
authors: Limburg
authors: Yong-Qian
authors: YQ
authors: Wu
authors: Yi
authors: Y
authors: Chen
authors: Raj
authors: R
authors: Soni
authors: Chad
authors: C
authors: Scott
authors: Douglas T
authors: DT
authors: Ross
authors: Hong
authors: H
authors: Guo
authors: Pamela
authors: P
authors: Howorth
authors: Heather
authors: H
authors: Valentine
authors: Shi
authors: S
authors: Liang
authors: Dawn
authors: D
authors: Spicer
authors: Mike
authors: M
authors: Fuller
authors: Joseph
authors: J
authors: Steiner
authors: Gregory S
authors: GS
authors: Hamilton
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation; D010875:Pipecolic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology; D022061:Tacrolimus Binding Protein 1A / Q000037:antagonists & inhibitors*; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D010875:Pipecolic Acids; D013449:Sulfonamides; D014508:Urea; D022061:Tacrolimus Binding Protein 1A