Phosphotyrosine-binding domains in signal transduction.
Protein phosphorylation provides molecular control of complex physiological events within cells. In many cases, phosphorylation on specific amino acids directly controls the assembly of multi-protein complexes by recruiting phospho-specific binding modules. Here, the function, structure, and cell biology of phosphotyrosine-binding domains is discussed.
Yaffe
Michael B
MB
Center for Cancer Research, E18-580, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA. myaffe@mit.edu
D000818:Animals; D001665:Binding Sites; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D008958:Models, Molecular; D019000:Phosphotyrosine / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D017978:Receptors, Growth Factor / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D018909:src Homology Domains
D008024:Ligands; D017978:Receptors, Growth Factor; D019000:Phosphotyrosine