Low-density lipoprotein reconstituted by pyropheophorbide cholesteryl oleate as target-specific photosensitizer.
To target tumors overexpressing low-density lipoprotein receptors (LDLr), a pyropheophorbide cholesterol oleate conjugate was synthesized and successfully reconstituted into the low-density lipoprotein (LDL) lipid core. Laser scanning confocal microscopy studies demonstrated that this photosensitizer-reconstituted LDL can be internalized via LDLr by human hepatoblastoma G(2) (HepG(2)) tumor cells.
Zheng
Gang
G
Department of Radiology, University of Pennsylvania Medical School, Philadelphia 19104, USA. zheng@rad.upenn.edu
Li
Hui
H
Zhang
Min
M
Lund-Katz
Sissel
S
Chance
Britton
B
Glickson
Jerry D
JD
D001667:Binding, Competitive; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D002788:Cholesterol Esters / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D011973:Receptors, LDL / Q000737:chemistry / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000378:metabolism
D002788:Cholesterol Esters; D008077:Lipoproteins, LDL; D017319:Photosensitizing Agents; D011973:Receptors, LDL; D002734:Chlorophyll; C040298:pyropheophorbide a; C014409:cholesteryl oleate