[Susceptibility to Mycobacterium leprae of congenic hypertensive nude rat (SHR/NCrj-rnu) and production of cytokine from the resident peritoneal macrophages].
We have established a congenic hypertensive nude rat strain, SHR/NCrj-rnu, carrying nude (rnu) and hypertension genes which was produced using females of the SHR/NCrj rat and males of the F344/NJcl nude rat by cross-intercross system for 12 generations. We demonstrated the susceptibility to M. leprae infection of SHR/NCrj-rnu rats as compared with F344/NJcl-rnu rats. SHR/NCrj-rnu rats were highly susceptible to M. leprae, and the SHR/NCrj-rnu rats of both sexes showed massive swelling of legs due to multiplication of M. leprae. However, F344/NJcl-rnu rats of both sexes revealed very poor susceptibility to M. leprae. There was a wide difference in the susceptibility to M. leprae between the SHR/NCrj-rnu and the F344/NJcl-rnu rats. We also examined the cytokine production. The resident peritoneal macrophages of SHR/NCrj-rnu rats produced IL-1 alpha, IL-6, IL-10 and TNF alpha, whereas those of F344/NJcl-rnu rats produced only TNF alpha.
Yogi
Yasuko
Y
Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aobacho, Higasimurayama-shi, Tokyo 189-0002, Japan.
Endoh
Masumi
M
Banba
Tomoko
T
Kobayashi
Masanori
M
Katoh
Hideki
H
Suzuki
Koichi
K
Nomaguchi
Hiroko
H
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis*; D004198:Disease Susceptibility; D005260:Female; D007918:Leprosy / Q000276:immunology* / Q000473:pathology; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D008297:Male; D009166:Mycobacterium leprae / Q000276:immunology*; D051381:Rats; D011916:Rats, Inbred F344 / Q000235:genetics; D011918:Rats, Inbred SHR / Q000235:genetics; D011923:Rats, Nude / Q000235:genetics
D016207:Cytokines