Increased expression of monocyte chemoattractant protein-1 in atherectomy specimens from patients with restenosis after percutaneous transluminal coronary angioplasty.
The plasma concentration of monocyte chemoattractant protein-1 (MCP-1) antigen is higher in patients with restenosis after coronary angioplasty than in those who do not restenose. In this study the MCP-1 expression of coronary atherectomy specimens was investigated by immunohistochemistry. Samples were obtained from 12 patients with restenosis and 15 with de novo lesions by directional coronary atherectomy. MCP-1 immunoreactivity was found in all patients in the restenosis group and in 8 of the de novo group. The frequency of macrophage expression was higher in the restenosis group than in de novo group. These results indicate that local expression of MCP-1 may be associated with the mechanisms of vascular remodeling after coronary angioplasty.
Hokimoto
Seiji
S
Division of Cardiology, Kumamoto Central Hospital, Kumamoto City, Japan. seisan@momo.so-net.ne.jp
Oike
Yuichi
Y
Saito
Taro
T
Kitaoka
Mitsuhiko
M
Oshima
Shuichi
S
Noda
Katsuo
K
Moriyama
Yasushi
Y
Ishibashi
Fumiyuki
F
Ogawa
Hisao
H
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D018932:Chemokine CCL2 / Q000097:blood*; D023903:Coronary Restenosis / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D018932:Chemokine CCL2