[Comparative analysis of blood and urinary electrolytes in normotensive and hypertensive normal, overweight and obese subjects aged 50-54 in the Bulgarian army].
Objective of the study is to investigate the hypotheses regarding the correlation of serum levels and urinary excretion of electrolytes with arterial hypertension. 211 subjects aged 50-54 from Bulgarian Army were studied. Evaluated were following parameters: SBP, DBP, BMI, Na+, K+ in blood serum; Na+, K+, NaCl, KCL, Na/K ratio, Ca++, Mg++ in 24-h urine excretion. Statistical analysis of variance, dispersion and correlation analysis (using 6D program from statistical pack BMDP) were applied. In the blood, no correlation was found between Na+ and both SBP and DBP. A significant positive correlation between SBP and K+ was found only in non-obese hypertensive females (R = 0.59, p < 0.05). Correlation between K+ and DBP was negative in separate groups with normal BMI (R = -0.84, R = -0.65, p < 0.05). In the 24-h urine excretion, no correlation was found between K+, NaCl, KCL and SBP, as well as between Na+ and SBP and DBP. Significant positive correlation was found between K+ and DBP in obese hypertensive subjects (R = 0.56, p < 0.05) and between NaCl and DBP (R = 0.47 up to R = 0.66 in separate groups, p < 0.05). Significant positive correlation between Ca++ and DBR (R = 0.47) was found in obese hypertensives. Mg++ correlates positively with DBP (R = 0.62 in some groups). Urine levels of Ca++ and Mg++ were significantly higher in normatensives. Electrolytes in blood and urine were closely related to DPB rather than to SBP. K+ levels in blood affect only DBP. Our data do not confirm the hypothesis for the positive correlation between urinary Na(+)-excretion and BP (except in obese subjects). The hypothesis about the inverse relation of K(+)-intake to BP, especially to DBP is confirmed by our data. The data regarding the Ca++ and Mg++ urinary excretion and their correlation with DBP and SBP are very discordant and do not give an opportunity to make definite conclusions. Our data confirmed the hypothesis about the natriuretic effect of Mg++, which possibly is of a protective value for development of AH in some obese persons.
Ramshev
K
K
Anev
E
E
Todorova
M
M
Asparukhova
D
D
D001794:Blood Pressure; D001835:Body Weight; D002031:Bulgaria / Q000453:epidemiology; D004573:Electrolytes / Q000097:blood* / Q000652:urine*; D006801:Humans; D008274:Magnesium / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000502:physiology; D009765:Obesity / Q000097:blood* / Q000652:urine*; D011188:Potassium / Q000032:analysis; D012964:Sodium / Q000032:analysis
D004573:Electrolytes; D012964:Sodium; D008274:Magnesium; D011188:Potassium