[Hypothyroidism protects the myocardium against ischemia-reperfusion injury].
This work describes experimental results indicating that mitochondria from hypothyroid rats are resistant to suffer membrane permeability transition as induced by matrix calcium accumulation. It is also shown that hypothyroidism provides resistance to myocardial reperfusion injury, after a period of 5 min ischemia. It is concluded that the protection is due to a low expression of mitochondrial proteins, as well as to a lack in cardiolipin as constituent of the lipid bilayer of the inner mitochondrial membrane.
Bobadilla
Israel
I
Departamento de Bioquímica, Instituto Nacional de Cardiología Ignacio Chávez, INCICH, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, 14080 México, D. F.
Franco
Martha
M
Cruz
David
D
Zamora
José
J
Robles
Sandra G
SG
Chávez
Edmundo
E
D000818:Animals; D007037:Hypothyroidism / Q000378:metabolism*; D008928:Mitochondria / Q000502:physiology*; D051381:Rats; D015427:Reperfusion Injury / Q000517:prevention & control*