Ion conduction and selectivity in the ryanodine receptor channel.
The ryanodine receptor channel is an intracellular membrane Ca2+-release channel. The investigation of ion translocation and discrimination in individual channels under voltage-clamp conditions has revealed that the channel can sustain very high rates of cation translocation, has high affinity for divalent cations and displays relatively poor discrimination between physiologically relevant cations. In this article I will discuss the mechanisms underlying these characteristic properties, the regions of the channel molecule likely to be involved in ion handling and speculate on the structure of the conduction pathway of Ca2+-release channels.
Williams
Alan J
AJ
Cardiac Medicine, National Heart & Lung Institute, Faculty of Medicine, Imperial College of Science, Technology & Medicine, Dovehouse St., London SW3 6LY, United Kingdom. a.j.williams@ic.ac.uk
D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002412:Cations / Q000378:metabolism; D017136:Ion Transport / Q000502:physiology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D020033:Protein Isoforms / Q000235:genetics / Q000502:physiology; D019837:Ryanodine Receptor Calcium Release Channel / Q000235:genetics / Q000502:physiology*; D017386:Sequence Homology, Amino Acid
D002412:Cations; D020033:Protein Isoforms; D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium