Surface immunoglobulins on the lymphocytes of the skate Raja naevus.
Living lymphocytes of the Elasmobranch fish, Raja naevus, have been examined for surface immunoglobulin (Ig) by treatment with a fluorescent anti-Ig system. Large numbers of Ig-positive cells (60-80%) were found in peripheral blood, spleen and thymus. Following modulation of the surface Ig with anti-Ig, resynthesis occurred, showing that the surface Ig is a product of the individual lymphocytes rather than material passively absorbed from the serum. Formation of caps was independent of temperature, occurring as readily at 4 degrees C as at 20 degrees C, a finding which presumably reflects the environmental conditions normally experienced by the skate. The presence of Ig-bearing lymphocytes in the adult skate thymus suggests a similarity to the amphibian larval thymus, which may be a primary lymphoid organ for the production of both T and B lymphocyte analogues.
Ellis
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D.A.F.S., Marine Laboratory, P.O. Box 31, Victoria Road, Aberdeen, Scotland.
Parkhouse
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D000663:Amphibians / Q000276:immunology; D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D001402:B-Lymphocytes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D011817:Rabbits; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*; D012860:Skates, Fish / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D011947:Receptors, Antigen, B-Cell