Evaluation of Podophyllum peltatum accessions for podophyllotoxin production.
In an effort to develop a sustainable source of podophyllotoxin for the production of anticancer drugs such as etoposide, teniposide and etopophos, Podophyllum peltatum accessions with podophyllotoxin-rich leaf biomass were identified and transplanted to different growing conditions by vegetative cuttings. Results indicate that the lignan profile in leaves does not change over time or due to environment conditions. Podophyllotoxin and alpha-peltatin content in the blades seems to be stable with an inverse relationship of concentration between these compounds. A podophyllotoxin-rich leaf accession showed low biosynthetic capability to synthesize alpha- and beta-peltatin and the converse was also true, indicating that selection and cultivation of high-yielding podophyllotoxin leaf biomass may reduce production costs.
Moraes
Rita M
RM
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA. rmoraes@olemiss.edu
Bedir
Ebru
E
Barrett
Holly
H
Burandt
Charles
C
Canel
Camilo
C
Khan
Ikhlas A
IA
D018533:Biomass; D017705:Lignans / Q000096:biosynthesis; D018515:Plant Leaves / Q000737:chemistry / Q000254:growth & development; D018547:Plant Stems / Q000737:chemistry / Q000254:growth & development; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000096:biosynthesis*; D011035:Podophyllum
D017705:Lignans; C049798:alpha-peltatin; D011034:Podophyllotoxin