title: The amphibian testis as model to study germ cell progression during spermatogenesis.
abstract: Testicular morphology of vertebrate testis indicates requirement of local control. In urodeles, the testis is organized in lobes of increasing maturity throughout the cephalocaudal axis. The anuran testis is organized in tubules. Spermatogenesis occurs in cysts composed by Sertoli cells enveloping germ cells at synchronous stages. Moreover, in numerous species germ cell progression lasts a year which defines the sexual cycle. Due to the above quoted features, research on factors regulating germ cell progression in amphibians may reach greater insight as compared with mammalian animal models. In particular, studies on endocrine and paracrine/autocrine factors involved in the regulation of germ cell functions reveal that fos activation and a J protein, previously specifically found in mouse testis, exert an important role in spermatogonial proliferation and maturation of post-meiotic stages, respectively.
authors: Dipartimento di Medicina Sperimentale, II Università di Napoli, Via costantinopoli 16, 80138 Napoli, Italy. riccardo.pierantoni@unina2.it
authors: R
authors: R
authors: Pierantoni
authors: G
authors: G
authors: Cobellis
authors: R
authors: R
authors: Meccariello
authors: C
authors: C
authors: Palmiero
authors: G
authors: G
authors: Fienga
authors: S
authors: S
authors: Minucci
authors: S
authors: S
authors: Fasano
mesh_terms: D020101:Acrosome Reaction; D000663:Amphibians / Q000502:physiology; D000818:Animals; D015153:Blotting, Western; D005854:Germ Cells / Q000502:physiology*; D008297:Male; D008540:Meiosis; D051379:Mice; D011898:Ranidae; D012708:Sertoli Cells / Q000502:physiology*; D013091:Spermatogenesis; D013737:Testis / Q000196:embryology* / Q000502:physiology*