Synthesis and antiviral evaluation of some new glycosylthioureas containing a quinazolinone nucleus.
A new synthesis of glycosylthioureas containing a quinazolinone nucleus is described utilizing per-O-acetylglycopyranosylisothiocyanates and several aminoquinazolinones as starting compounds. Structural proofs of these compounds are provided from elemental analyses, IR, 1H and 13C NMR spectra and mass spectra. The biological activity of these compounds has been studied.
Saleh
Mohamed A
MA
Chemistry Department, Faculty of Science, Tanta University, Egypt.
Abdel-Megged
Mohamed F
MF
Abdo
Mohamed A
MA
Shokr
Abdel-Basset M
AB
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002247:Carbon Isotopes / Q000737:chemistry / Q000378:metabolism; D006678:HIV / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D009858:Oncogenic Viruses / Q000187:drug effects; D011799:Quinazolines / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D013890:Thiourea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology
D000998:Antiviral Agents; D002247:Carbon Isotopes; D011799:Quinazolines; D013890:Thiourea