Electrospray ionization tandem mass spectrometric characteristics and fragmentation mechanisms of distamycin analogues.
The electrospray ionization tandem mass spectrometric (ESI-MS/MS) characteristics and fragmentation mechanisms of eight distamycin analogues containing N-methylpyrrole and N-methylimidazole were investigated. The members of two isomeric groups of distamycin analogues with the same elemental composition can be distinguished by MS/MS spectra of protonated molecules and of significant fragment ions.
Tang
Feili
F
Department of Chemical Biology, The Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry, Peking University, Beijing 100871, PR China.
Wang
Jin
J
Liu
Dan
D
Yuan
Gu
G
Liu
Yen
Y
Jin Zhu
Chang
C
Fen Zhao
Yu
Y
D000998:Antiviral Agents / Q000032:analysis*; D004214:Distamycins / Q000032:analysis*; D007093:Imidazoles / Q000032:analysis; D015394:Molecular Structure; D011758:Pyrroles / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
D000998:Antiviral Agents; D004214:Distamycins; D007093:Imidazoles; D011758:Pyrroles; C030000:stallimycin; C096654:N-methylpyrrole; C018100:1-methylimidazole