Changes in antioxidant status of lung tissue in experimental diabetes in rabbits.
OBJECTIVE
Hyperglycaemia can result in oxidative stress which may affected as cellular tissue damage.


METHODS
After 3, 6, 12 and 24 weeks of hyperglycaemia oxidative stress related parameters were measured in lung tissue of diabetic and control rabbits.


RESULTS
Decreased activities of antioxidative compounds and intensification of lipid peroxidation process were found in diabetic lung.


CONCLUSIONS
The data obtained suggest that hyperglycaemia induces oxidative stress in lung tissue which may play an important role in pathogenesis of diabetic complications.
Gumieniczek
Anna
A
Department of Medicinal Chemistry, Medical University of Lublin, Chodźki Str. 6, 20-093 Lublin, Poland. kzchl@asklepios.am.lublin.pl
Hopkała
Hanna
H
Wójtowicz
Zbigniew
Z
Wysocka
Monika
M
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D016718:Arachidonic Acid / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation; D008171:Lung Diseases / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011817:Rabbits; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D013438:Sulfhydryl Compounds; D016718:Arachidonic Acid; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D005947:Glucose