Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders.
Variants of the functional polymorphism in the serotonin transporter (upstream regulatory region: 5-HTTLPR), the tryptophan hydroxylase (TPH), the monoamine oxidase A (MAO-A), and the dopamine receptor D4 (DRD4) genes have all been associated with mood disorders. The aim of this study was to test those hypotheses by using a family-based association approach. Both diagnoses and psychopathology were used for phenotype definitions. A total of 134 nuclear families with mood disorders, with probands affected by bipolar (n = 103) or major depressive (n = 58) disorders, were included in the study. All subjects were typed for the above-mentioned gene variants using polymerase chain reaction (PCR) technique. No significant transmission disequilibrium was found in the overall sample for any polymorphism. A separate analysis of bipolar subjects only, or the use of continuous psychopathologic traits as affectation status did not influence the observed results. Our study did not support the involvement of 5-HTTLPR, TPH, MAO-A, or DRD4 polymorphisms in mood disorders.
Serretti
Alessandro
A
Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy. serretti.alessandro@hsr.it
Cristina
Silvano
S
Lilli
Roberta
R
Cusin
Cristina
C
Lattuada
Enrico
E
Lorenzi
Cristina
C
Corradi
Barbara
B
Grieco
Gaetano
G
Costa
Alfredo
A
Santorelli
Filippo
F
Barale
Francesco
F
Nappi
Giuseppe
G
Smeraldi
Enrico
E
D000328:Adult; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000378:metabolism; D026901:Membrane Transport Proteins; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics* / Q000378:metabolism; D019964:Mood Disorders / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D009419:Nerve Tissue Proteins; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics* / Q000378:metabolism; D050638:Receptors, Dopamine D4; D050486:Serotonin Plasma Membrane Transport Proteins; D013223:Statistics as Topic; D014365:Tryptophan Hydroxylase / Q000235:genetics* / Q000378:metabolism
D002352:Carrier Proteins; C493599:DRD4 protein, human; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D017448:Receptors, Dopamine D2; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D050638:Receptors, Dopamine D4; D014365:Tryptophan Hydroxylase; D008995:Monoamine Oxidase