Effect of repeated treatment with reboxetine on the central alpha1-adrenergic system.
The obtained results indicate that repeated administration of reboxetine (selective noradrenaline reuptake inhibitor, without any affinity for neurotransmitter receptors) increased the responsiveness of alpha1-adrenergic system (potentiating the methoxamine-induced exploratory hyperactivity in rats and clonidine-induced aggressiveness in mice), as tricyclic antidepressants did. However, the question whether the increased functional responsiveness found in the present study is important for the clinical antidepressant efficacy, remains open.
Rogóz
Z
Z
Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Kolasiewicz
W
W
D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology*; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000374:Aggression / Q000187:drug effects; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D051379:Mice; D009025:Morpholines / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000077593:Reboxetine; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects* / Q000378:metabolism
D018759:Adrenergic Uptake Inhibitors; D000316:Adrenergic alpha-Agonists; D009025:Morpholines; D018340:Receptors, Adrenergic, alpha-1; D000077593:Reboxetine; D008729:Methoxamine; D003000:Clonidine; D009638:Norepinephrine