Effect of tamoxifen treatment at adolescent age on the sexual behaviour and steroid hormone receptor binding of adult female rats.
Hormonal imprinting takes place perinatally, at the first encounter between the target hormone and its developing receptor. However, there is a secondary critical period of imprinting at puberty. In these periods molecules similar to the hormones (members of the same hormone family, antagonists, certain environmental pollutants, etc.) can cause faulty imprinting with lifelong consequences. In the present experiments 5+2 days of tamoxifen treatment (120 microg/day) at adolescent age dramatically (from approx. 40% to 10%) reduced the sexual activity (Meyerson index and lordosis quotient) of female rats, soon after the finishment of the treatment and between four to six weeks after treatment. Similar results were observed in animals neonatally treated with allylestrenol and tamoxifen treated at puberty. Thymic glucocorticoid receptor and uterine estrogen receptor binding capacity were not influenced.
Csaba
G
G
Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary. csagyor@dgci.sote.hu
Karabélyos
C
C
Inczefi-Gonda
A
A
D000375:Aging / Q000378:metabolism* / Q000523:psychology*; D000500:Allylestrenol / Q000494:pharmacology; D000818:Animals; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D045167:Progesterone Congeners / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013629:Tamoxifen / Q000494:pharmacology*
D004965:Estrogen Antagonists; D045167:Progesterone Congeners; D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D013629:Tamoxifen; D000500:Allylestrenol