title: Antifungal sordarins. part 3: synthesis and structure-activity relationships of 2',3'-fused oxirane derivatives.
abstract: A number of new 2',3'-fused oxirane derivatives were synthesized for structure-activity relationship study. Many of these derivatives exhibit high potency against Candida spp. In addition, sordarin manno epoxide derivative 6 presents in vivo therapeutic effect in mice and is considered a promising antifungal lead within this series.
authors: GlaxoSmithKline, Research Department, Parque Tecnológico de Madrid, Severo Ochoa, 2. 28760 Tres Cantos, Madrid, Spain.
authors: Julia
authors: J
authors: Castro
authors: Juan C
authors: JC
authors: Cuevas
authors: José M
authors: JM
authors: Fiandor
authors: Ma Teresa
authors: MT
authors: Fraile
authors: Federico Gómez
authors: FG
authors: de las Heras
authors: José R
authors: JR
authors: Ruiz
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects*; D015195:Drug Design; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005027:Ethylene Oxide / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007192:Indenes; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D004852:Epoxy Compounds; D007192:Indenes; C003329:sordarin; D005027:Ethylene Oxide