Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder.
Various types of evidence implicate nitric oxide and an oxidant, possibly peroxynitrite, in MCS and chemical intolerance (CI). The positive feedback loops proposed earlier for CFS may explain the chronic nature of MCS (CI) as well as several of its other reported properties. These observations raise the possibility that this proposed elevated nitric oxide/peroxynitrite mechanism may be the mechanism of a new disease paradigm, answering the question raised by Miller earlier: "Are we on the threshold of a new theory of disease?"
Pall
M L
ML
School of Molecular Biosciences, Washington State University, Pullman 99164-4660, USA. martin_pall@wsu.edu
Satterlee
J D
JD
D000818:Animals; D001120:Arginine / Q000096:biosynthesis; D001812:Blood-Brain Barrier / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000009:adverse effects / Q000494:pharmacology; D016207:Cytokines / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D015673:Fatigue Syndrome, Chronic / Q000209:etiology* / Q000378:metabolism; D005246:Feedback; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology; D007306:Insecticides / Q000009:adverse effects / Q000494:pharmacology; D007696:Kindling, Neurologic / Q000187:drug effects; D023421:Models, Animal; D008954:Models, Biological; D018777:Multiple Chemical Sensitivity / Q000209:etiology* / Q000378:metabolism; D019798:Neopterin / Q000096:biosynthesis; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II; D009943:Organophosphorus Compounds; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D030421:Peroxynitrous Acid / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000096:biosynthesis / Q000502:physiology; D013313:Stress Disorders, Post-Traumatic / Q000209:etiology* / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects; D015262:Xenobiotics / Q000009:adverse effects / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D016207:Cytokines; D004791:Enzyme Inhibitors; D007306:Insecticides; D009943:Organophosphorus Compounds; D011976:Receptors, Muscarinic; D015262:Xenobiotics; D030421:Peroxynitrous Acid; D009569:Nitric Oxide; D019798:Neopterin; D001120:Arginine; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II