IgG and IgG subclasses deficiency in children undergoing continuous ambulatory peritoneal dialysis and its provocative factors.
BACKGROUND
Low levels of serum IgG or IgG subclasses may be responsible for the defective peritoneal defense and for peritonitis attacks in continuous ambulatory peritoneal dialysis (CAPD) children. Malnutrition, peritoneal loss or frequent peritonitis may lead to IgG or IgG subclasses deficiency.


METHODS
Levels of IgG subclasses were determined in 12 children undergoing CAPD treatment. Radial immunodiffusion technique was used for determination. Patients were aged from 6 to 16 years (mean age 12.3 years) and had been on CAPD for 11-26 months (mean duration 19.4 months). We evaluated whether IgG and IgG subclasses deficiency are related to malnutrition, the peritonitis rate and the duration of CAPD using the SPSS program.


RESULTS
Serum total IgG levels were found to be low in eight out of 12 patients. Eight patients showed low levels of IgG1, four patients IgG2, one patient IgG3 and three patients IgG4. Total IgG values were found to be positively correlated to malnutrition status, peritonitis rate and duration of CAPD. The IgG2 values were found to be related to the duration of CAPD. The IgG4 values were found to be correlated to the peritonitis rates.


CONCLUSIONS
The IgG and IgG subclasses deficiency may develop in children while on CAPD treatment. Periodical determinations of either serum IgG or the subclasses may be useful in the follow-up of these patients.
Akman
Sema
S
Department of Pediatric Nephrology, Akdeniz University Medical Faculty, Antalya, Turkey. sakman@med.akdeniz.edu.tr
Güven
Ayfer Gür
AG
Ince
Selma
S
Yeğin
Olcay
O
D000293:Adolescent; D000361:Agammaglobulinemia / Q000209:etiology*; D002648:Child; D005260:Female; D006801:Humans; D017099:IgG Deficiency / Q000209:etiology*; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D009748:Nutrition Disorders / Q000276:immunology; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010538:Peritonitis / Q000276:immunology
D007074:Immunoglobulin G