title: Positive and negative roles of CD72 in B cell function.
abstract: Regulation of B cell activation depends on integration of signals transmitted by the B cell receptor (BCR) and a variety of co-receptors. CD72 is a B cell co-receptor that is expressed in all stages of B cell development except plasma cells. Ligation of CD72 enhances B cell growth and differentiation. Recently, the class IV semaphoring, CD100, has been identified as the natural ligand for CD72. Cytoplasmic domain of CD72 has been shown to be associated with SHP-1 leading to the proposal that the positive effects of CD72 on B cell response may result from sequestration of negative signals from BCR. However, association of CD72 with Grb2 and/or CD19 suggests that CD72 could transmit positive signals. Based on these data, we propose a dual signaling model of CD72.
authors: Department of Microbiology and Immunology, The Sanders Brown Center on Aging, University of Kentucky, Lexington 40536, USA.
authors: Hsin-Jung
authors: HJ
authors: Wu
authors: Subbarao
authors: S
authors: Bondada
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D008024:Ligands; D008562:Membrane Glycoproteins / Q000276:immunology; D039961:Semaphorins; D015398:Signal Transduction / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; C093224:CD100 antigen; C064228:CD72 protein, human; D008024:Ligands; D008562:Membrane Glycoproteins; D039961:Semaphorins