Reproductive choices for couples with haemophilia.
: Summary. The impact of having a child with an inherited bleeding disorder such as haemophilia can have a far-reaching effect on the individual as well as other close family members. This situation is further complicated in the case of human immunodeficiency (HIV) serodiscordant couples, where the haemophilic man is affected with HIV through infected blood products whilst his partner is seronegative and wanting to have children. It is essential that information on the effects of haemophilia, its inheritance, the possibilities of antenatal diagnosis, the consideration of selective abortion and the new reproductive opportunities available to these couples are made accessible so that an informed decision about proceeding with having a family can be made. Couples may wish to have a family through nonreproductive methods such as fostering or adoption. Alternatively, they may wish to remain childless. In this paper, the terms 'having children' and 'having a family' will refer to conception through biological reproduction. Pre-implantation genetic diagnosis (PGD) offers families at risk of having a child with certain inherited genetic disorders the opportunity to give birth to an unaffected child. It may be considered as an option for couples who would not wish to have prenatal diagnosis leading to possible termination of a pregnancy. Assisted conception techniques, such as 'sperm washing' or the use of 'donor sperm', offer serodiscordant couples affected by HIV a risk-reduced or risk-free opportunity, respectively, to have a child without infecting the mother, who could in turn infect the fetus by vertical transmission. This article, in addition to outlining the inheritance of haemophilia and the more common prenatal screening and diagnostic tests, discusses in more detail the latest reproductive opportunities available for families affected by haemophilia and considering having a family.
Oyesiku
J O O
JO
Oxford Haemophilia Centre, Churchill Hospital, Oxford, UK; IVF Unit, Hammersmith Hospital, London, UK. lara.oyesiku@orh.nhs.uk
Turner
C F
CF
D000163:Acquired Immunodeficiency Syndrome; D005193:Family Planning Services; D005817:Genetic Counseling; D006467:Hemophilia A / Q000628:therapy / Q000821:virology; D002836:Hemophilia B / Q000628:therapy / Q000821:virology; D006801:Humans; D007316:Insemination, Artificial, Heterologous; D019836:Preimplantation Diagnosis; D011296:Prenatal Diagnosis; D012099:Reproductive Techniques