Effects of clonidine and dopamine on gastric tone.
OBJECTIVE
The effects of clonidine and dopamine, both alone and together, on gastric tone were studied using an electronic barostat. This enabled volume changes to be measured in an intragastric bag with a constant preset pressure.


METHODS
Nine healthy male volunteers were each studied on two occasions in a randomized order. During each study period, a continuous infusion of dopamine was given, starting with a dose of 2.5 microg kg(-1) min(-1), and then increasing at 15-min intervals to 5.0 and 7.5 microg kg(-1) min(-1). Clonidine 150 microg intravenously was given on one occasion during the infusion of dopamine (7.5 microgkg(-1) min(-1)) and on the other occasion 15 min before the dopamine infusion started.


RESULTS
During dopamine infusion, the intragastric bag volume increased (gastric tone therefore decreasing) in a dose-related manner (total increase 290 +/- 114 mL). Clonidine given either during or before dopamine infusion did not influence the bag volume. When the dopamine infusion started 15 min after clonidine, the bag volume did not change until the infusion of dopamine reached 7.5 microg kg(-1) min(-1) (total increase 205 +/- 156 mL).


CONCLUSIONS
Dopamine reduced gastric tone in a dose-related manner, and clonidine did not influence gastric tone per se. If clonidine is given before dopamine, the effects of dopamine are reduced.
Levein
N G
NG
Orebro Medical Center Hospital, Department of Anesthesia and Intensive Care, Sweden.
Thörn
S E
SE
Wattwil
M
M
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects*; D013270:Stomach / Q000187:drug effects* / Q000502:physiology
D000316:Adrenergic alpha-Agonists; D003000:Clonidine; D004298:Dopamine