Differences in the immunological activities of antibody-secreting cell precursors in mouse spleen selected on the basis of antigen-binding capacity.
Mouse spleen cells transfer a retarded and lower than normal IgG antibody response after removal of cells with a high antigen-binding capacity. The population enriched in these latter cells transfers a response equal to or, more often, higher than the response of the unfractionated controls and does not appear to have originated from previous priming of the mice. These cells are present in athymic nude mice and appear to be more susceptible to inactivation by an anti-Ig antiserum and complement than precursors of IgM antibody-secreting cells.
Lafleur
L
L
Basel Institute for Immunology, Basel.
Mitchell
G F
GF
D000818:Animals; D020296:Animals, Congenic; D000921:Antibody-Producing Cells / Q000276:immunology*; D000941:Antigens / Q000378:metabolism; D016175:B-Lymphocyte Subsets / Q000276:immunology; D002469:Cell Separation; D004912:Erythrocytes / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D006736:Horses; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D066298:In Vitro Techniques; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008819:Mice, Nude; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000276:immunology
D000941:Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M