title: Cefpirome sulphate for gynaecological infections and prophylaxis of non-laparotomy surgery in patients with benign disease.
abstract: We organized a study group to conduct a clinical trial in patients with various gynaecological infections, and we also assessed the efficacy of a single dose of cefpirome sulphate as prophylaxis after vaginal hysterectomy. Cefpirome sulphate (CROM) was administered to 100 patients with gynaecological infections and the clinical and antibacterial efficacy was evaluated in 88 patients. The improvement rate was 77.0% (67/87) and the bacterial eradication rate 67.8% (40/59). Nineteen of the 210 patients enrolled in the comparison of CROM with cefmetazole sodium (CMET) prophylaxis developed postoperative infections. The incidence of infection showed no significant difference between the CROM group (n=11, 10.6%) and the CMET group (n=8, 7.5%) (P=0.56). Although these results suggest that CROM may be effective for the treatment of gynaecological infections and has a good safety profile, it was not superior to CMET as prophylaxis in women undergoing non-laparotomy procedures at our hospital.
authors: 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan. gynhayas@asahikawa-med.ac.jp
authors: Hiroaki
authors: H
authors: Hayashi
authors: Tsuyoshi
authors: T
authors: Yamashita
authors: Toshiyuki
authors: T
authors: Nakata
authors: Tetsuya
authors: T
authors: Huji
authors: Takashi
authors: T
authors: Kojima
authors: Hideto
authors: H
authors: Katayama
authors: Mutsuo
authors: M
authors: Ishikawa
mesh_terms: D000328:Adult; D000368:Aged; D019072:Antibiotic Prophylaxis; D001424:Bacterial Infections / Q000188:drug therapy* / Q000517:prevention & control*; D015311:Cefmetazole / Q000009:adverse effects / Q000627:therapeutic use*; D002511:Cephalosporins / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy / Q000517:prevention & control* / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D000097572:Cefpirome
chemical_list: D015311:Cefmetazole; D002511:Cephalosporins; D000097572:Cefpirome