Spatial representation of the glomerular map in the Drosophila protocerebrum.
In the fruit fly, Drosophila, olfactory sensory neurons expressing a given receptor project to spatially invariant loci in the antennal lobe to create a topographic map of receptor activation. We have asked how the map in the antennal lobe is represented in higher sensory centers in the brain. Random labeling of individual projection neurons using the FLP-out technique reveals that projection neurons that innervate the same glomerulus exhibit strikingly similar axonal topography, whereas neurons from different glomeruli display very different patterns of projection in the protocerebrum. These results demonstrate that a topographic map of olfactory information is retained in higher brain centers, but the character of the map differs from that of the antennal lobe, affording an opportunity for integration of olfactory sensory input.
Wong
Allan M
AM
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032, USA.
Wang
Jing W
JW
Axel
Richard
R
D000825:Animal Structures / Q000166:cytology / Q000254:growth & development* / Q000294:innervation; D000818:Animals; D030801:Animals, Genetically Modified; D001369:Axons / Q000378:metabolism / Q000648:ultrastructure; D019521:Body Patterning / Q000502:physiology*; D001931:Brain Mapping; D002454:Cell Differentiation / Q000502:physiology*; D003712:Dendrites / Q000378:metabolism / Q000648:ultrastructure; D004331:Drosophila melanogaster / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D024521:Mushroom Bodies / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology; D009833:Olfactory Pathways / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D018034:Olfactory Receptor Neurons / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D012903:Smell / Q000502:physiology; D013687:Telencephalon / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism