[Mineralization of the dental pulp: contributions of tissue engineering to tomorrow's therapeutics in odontology].
When bioactive molecules such as bone sialoprotein (BSP), bone morphogenetic protein-7 (BMP-7, also termed OP-1) and chondrogenic Inducing Agents (CIA, A+4 and A-4) were implanted in the pulp of the first upper molars, mineralizations were induced. They were either limited to the formation of a reparative dentinal bridge closing the pulpal wound (CIA A+4), or filled the mesial part of the coronal pulp (BSP), or filled totally the pulp located in the root canal (BMP-7 and CIA A-4). Consequently, these molecules may change in the next future the every day practice in dentistry.
Goldberg
M
M
Laboratoire biologie et physiopathologie crâniofaciales EA 2496, faculté de chirurgie dentaire, université Paris V, 1, rue Maurice Arnoux, 92120 Montrouge, France.
Six
N
N
Decup
F
F
Bourd
K
K
Palmier
K
K
Salih
E
E
Veis
A
A
Lasfargues
J J
JJ
D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage* / Q000494:pharmacology; D015921:Dental Implants; D003782:Dental Pulp / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D003785:Dental Pulp Capping / Q000379:methods*; D003786:Dental Pulp Cavity; D003788:Dental Pulp Diseases / Q000628:therapy*; D003810:Dentinogenesis / Q000187:drug effects*; D004337:Drug Carriers; D058574:Integrin-Binding Sialoprotein; D008963:Molar; D011506:Proteins / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage / Q000494:pharmacology; D012795:Sialoglycoproteins / Q000008:administration & dosage* / Q000494:pharmacology; D023822:Tissue Engineering / Q000379:methods*; D016212:Transforming Growth Factor beta
C525821:Bmp7 protein, rat; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D015921:Dental Implants; D004337:Drug Carriers; C546873:Ibsp protein, rat; D058574:Integrin-Binding Sialoprotein; D011506:Proteins; D011993:Recombinant Fusion Proteins; D012795:Sialoglycoproteins; D016212:Transforming Growth Factor beta