title: Clonal groupings in serogroup X Neisseria meningitidis.
abstract: The genetic diversity of 134 serogroup X Neisseria meningitis isolates from Africa, Europe, and North America was analyzed by multilocus sequence typing and pulsed-field gel electrophoresis. Although most European and American isolates were highly diverse, one clonal grouping was identified in sporadic disease and carrier strains isolated over the last 2 decades in the United Kingdom, the Netherlands, Germany, and the United States. In contrast to the diversity in the European and American isolates, most carrier and disease isolates recovered during the last 30 years in countries in the African meningitis belt belonged to a second clonal grouping. During the last decade, these bacteria have caused meningitis outbreaks in Niger and Ghana. These results support the development of a comprehensive conjugate vaccine that would include serogroup X polysaccharide.
authors: Swiss Tropical Institute, Socinstrasse 57, 4002 Basel, Switzerland.
authors: Sébastien
authors: S
authors: Gagneux
authors: Thierry
authors: T
authors: Wirth
authors: Abraham
authors: A
authors: Hodgson
authors: Ingrid
authors: I
authors: Ehrhard
authors: Giovanna
authors: G
authors: Morelli
authors: Paula
authors: P
authors: Kriz
authors: Blaise
authors: B
authors: Genton
authors: Tom
authors: T
authors: Smith
authors: Fred
authors: F
authors: Binka
authors: Gerd
authors: G
authors: Pluschke
authors: Mark
authors: M
authors: Achtman
mesh_terms: D000349:Africa / Q000453:epidemiology; D000483:Alleles; D016521:Electrophoresis, Gel, Pulsed-Field; D005060:Europe / Q000453:epidemiology; D006801:Humans; D008589:Meningococcal Infections / Q000382:microbiology; D009345:Neisseria meningitidis / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D009656:North America / Q000453:epidemiology; D010802:Phylogeny; D012189:Retrospective Studies; D012703:Serotyping