Prevalence of hepatitis virus infection in association with oral diseases requiring surgery.
OBJECTIVE
We evaluated the prevalence of hepatitis virus infection in a large population of patients in terms of diseases requiring oral surgery.


METHODS
Retrospective case survey.


METHODS
Prevalence of hepatitis B and C virus (HBV, HCV) infection were compared between oral diseases such as inflammation, cysts, cancer, trauma, benign tumors, impacted teeth, or jaw deformity in dental inpatients (n = 5830) with adjustment for age, gender, and history of surgery.


RESULTS
Of 4402 inpatients, 94 had HB surface(s) antigen (2.1%), while 151 of 2613 were seropositive for HCV (5.8%). Prevalences of HBs antigen and HCV antibody exceeded those in the general population. HBs antigen was more prevalent in patients with benign oral tumors than in patients with impacted teeth, whether or not adjustment was made for age (odds ratios, 4.246 and 5.055 with and without age adjustment, respectively; P < 0.05). On the other hand, HCV antibody was more prevalent in patients with oral cancer than in those with impacted teeth before adjustment for age (odds ratios, 2.433; P < 0.05), but this difference was reversed with age adjustment (odds ratios, 0.443; P < 0.05).


CONCLUSIONS
HBs antigen was more prevalent in patients with benign oral tumors, while HCV antibody was higher in patients with oral cancer. However, this increased incidence of HCV antibody apparently was a reflection of age. HCV infection may not have an etiologically important association with oral cancer.
Takata
Yutaka
Y
Department of Internal Medicine, Kyushu Dental College, Kitakyushu, Japan. yutaka@kyu-dent.ac.jp
Takahashi
Tetsu
T
Fukuda
Jinichi
J
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D003560:Cysts / Q000453:epidemiology; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006526:Hepatitis C / Q000453:epidemiology*; D018937:Hepatitis C Antibodies / Q000032:analysis; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007569:Jaw Abnormalities / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000293:injuries; D009059:Mouth Diseases / Q000453:epidemiology* / Q000601:surgery; D009062:Mouth Neoplasms / Q000453:epidemiology* / Q000601:surgery; D016017:Odds Ratio; D015995:Prevalence; D012189:Retrospective Studies; D012737:Sex Factors; D013223:Statistics as Topic; D013280:Stomatitis / Q000453:epidemiology; D014095:Tooth, Impacted / Q000453:epidemiology
D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies