Comparative resin kinetics using in situ fluorescence measurements.
The aminolysis of a novel activated ester resin was utilized for kinetic study via continuous in situ fluorescence measurements. A variety of resin compositions (polystyrene, JandaJel, ArgoPore, TentaGel, NovaGel, and PEGA) and solvents (dimethylformamide, acetonitrile, tetrahydrofuran, 1,2-dichlorethane, and toluene) were tested to compare their effects on the reaction rate. A linear relationship between the reaction rate and (solvent polarity x swelling of resin) was elucidated for the aminolysis reaction.
Walsh
Daniel P
DP
Department of Chemistry, New York University, New York, New York 10003, USA.
Pang
Christopher
C
Parikh
Puja B
PB
Kim
Young-Soo
YS
Chang
Young-Tae
YT
D000577:Amides / Q000138:chemical synthesis; D001596:Benzylamines / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D005453:Fluorescence; D005470:Fluorometry; D007700:Kinetics; D012117:Resins, Synthetic / Q000592:standards*; D012997:Solvents / Q000494:pharmacology
D000577:Amides; D001596:Benzylamines; D012117:Resins, Synthetic; D012997:Solvents