Manipulating chemoattractant and receptor genes.
Chemoattractants, including classical chemotactic factors and members of the chemokine superfamily, function as inducers of leukocyte trafficking and activation based on interactions with seven transmembrane (STM), G protein-coupled receptors. These molecules are expressed by many cell types either constitutively or upon stimulation. Considerable knowledge about the pathophysiological role of chemoattractants and their receptors has been accumulated during the past two decades. However, recent studies using transgenic and gene targeting technology have provided a better illustration of the importance and complexity of the involvement of chemoattractants and receptors in leukocyte trafficking, inflammation, infection, immune responses, development, angiogenesis/angiostasis, and malignant tumors.
Le
Yingying
Y
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Cui
Youhong
Y
Iribarren
Pablo
P
Ying
Guoguang
G
Wang
Ji Ming
JM
D000818:Animals; D002630:Chemotactic Factors / Q000235:genetics*; D018390:Gene Targeting; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D023421:Models, Animal; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic / Q000235:genetics*; D018000:Receptors, Peptide / Q000235:genetics*; D019076:Transgenes
D002630:Chemotactic Factors; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic; D018000:Receptors, Peptide