Persisting epithelial herpes simplex keratitis while on cyclosporin-A ointment.
BACKGROUND
This is the first report of cyclosporin-A ointment (CsA) adversely affecting epithelial herpes simplex virus keratitis in a corneal graft.


METHODS
The details of this case were obtained from the patient's record at The Wilmer Ophthalmological Institute.


RESULTS
Ceasing CsA ointment resulted in resolution of the epithelial HSV keratitis.


CONCLUSIONS
Immunosuppression caused by CsA ointment resulted in persisting epithelial HSV keratitis despite adequate topical treatment.
Field
A J
AJ
Ridley Eye Clinic, Box 539, Manunda, Cairns 4870, Queensland.
Gottsch
J D
JD
D000368:Aged; D003315:Cornea / Q000503:physiopathology / Q000821:virology*; D016039:Corneal Transplantation; D016572:Cyclosporine / Q000009:adverse effects*; D004847:Epithelial Cells / Q000821:virology; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy; D018259:Herpesvirus 1, Human / Q000254:growth & development*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016849:Keratitis, Herpetic / Q000503:physiopathology / Q000821:virology*; D009824:Ointments; D014775:Virus Activation / Q000187:drug effects*
D007166:Immunosuppressive Agents; D009824:Ointments; D016572:Cyclosporine