[Examination and evaluation of lipopolysaccharide binding protein in serum of patients with chronic hepatitis, severe hepatitis].
OBJECTIVE
To observe the variability of lipopolysaccharide binding protein (LBP) in patients with chronic hepatitis and severe hepatitis.


METHODS
Using ELISA the authors detected the serum LBP of 71 patients including 16 with chronic hepatitis, 15 with post hepatitis cirrhosis, 12 with severe hepatitis and 17 healthy controls.


RESULTS
The serum LBP of chronic liver disease group was 35 166.25 micrograms/L, which was higher than that of healthy control group (18 590.00 micrograms/L). The serum LBP of chronic hepatitis and cirrhosis patients was higher than that of severe hepatitis cases. These differences were significant. The serum LBP had positive correlation with prothrombin activity (PTA) (r =0.395 8,P <0.01), while it had no significant correlation with serum ALT and total bilirubin levels (r =0.164 5,0.189 4, respectively, P <0.05).


CONCLUSIONS
Serum LBP could be used as an index for predicting liver function compensation.
Yin
B
B
Department of Infectious Diseases, The First Hospital of Peking University, Beijing 10034, China.
Yu
M
M
Zeng
Z
Z
Tian
G S
GS
D000209:Acute-Phase Proteins; D000328:Adult; D002352:Carrier Proteins / Q000097:blood*; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood*; D019698:Hepatitis C, Chronic / Q000097:blood; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D008562:Membrane Glycoproteins; D008875:Middle Aged; D000099231:Lipopolysaccharide-Binding Protein
D000209:Acute-Phase Proteins; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D000099231:Lipopolysaccharide-Binding Protein