Population genomics: ageing by association.
Mutations in the gene Klotho lead to premature ageing in mice. Recent work on human genetic variation has identified an association between a particular allele of Klotho and human lifespan. A harbinger of things to come, this work illustrates the power and growth potential for association studies of human ageing.
Pletcher
Scott D
SD
Galton Laboratory, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK. s.pletcher@ucl.ac.uk
Stumpf
Michael P H
MP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D002648:Child; D005787:Gene Frequency; D005828:Genetics, Population; D005966:Glucuronidase; D006801:Humans; D000090265:Klotho Proteins; D008136:Longevity; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D008875:Middle Aged
D008565:Membrane Proteins; D005966:Glucuronidase; D000090265:Klotho Proteins