Effects of anxiolytic drugs on some behavioral consequences in olfactory bulbectomized rats.
The present study was designed to evaluate the effects of bulbectomy and acute administration of anxiolytic drugs (diazepam, 10 mg/kg; chlordiazepoxide, 10 mg/kg) on the behavior of both sham-operated and olfactory bulbectomized rats in two tests predictive of anxiolytic activity: plus-maze test and Vogel's conflict test. We investigated also the effect of flumazenil (10 mg/kg), a benzodiazepine receptors antagonist, both on control and drug-treated animals. We also evaluated behavior of animals in conditioned place aversion procedure. Our results show the decreased level of anxiety in bulbectomized animals comparing with sham-operated rats. Anxiolytic drugs further deepen this effect.
Wierońska
J M
JM
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Papp
M
M
Pilc
A
A
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects; D005442:Flumazenil / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D009830:Olfactory Bulb / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D014151:Anti-Anxiety Agents; D018757:GABA Modulators; D005442:Flumazenil