title: Differentiation of malignant and benign musculoskeletal tumors: combined color and power Doppler US and spectral wave analysis.
abstract: OBJECTIVE
  To assess the use of combined color Doppler ultrasonography (US), power Doppler US, and spectral wave analysis (SWA) in differentiating malignant and benign musculoskeletal tumors.
  
  
  METHODS
  Seventy-nine musculoskeletal tumors (34 malignant, 45 benign) were examined with color and power Doppler US and SWA. Two radiologists independently assessed US images and SWA findings. Echotexture and vessel characteristics such as stenoses, occlusions, loops, shunts, trifurcations, vascular pattern, and resistive index were evaluated. All tumors were subject to US-guided or open biopsy for histologic correlation.
  
  
  RESULTS
  Combined color and power Doppler US and SWA revealed four major (stenosis, occlusion, trifurcation, vascular pattern) and three minor (shunt, self loop, resistive index) vessel characteristics, which proved helpful in differentiating benign from malignant lesions. Echotexture showed moderate sensitivity (82% [28 of 34 tumors]) and low specificity (38% [17 of 45 tumors]). When comparing several combinations of vessel characteristics, a combination of any two major characteristics demonstrated the best results (sensitivity, 94% [33 of 39 tumors]; specificity, 93% [three of 45 tumors]). Combining more than two characteristics resulted in lower sensitivity.
  
  
  CONCLUSIONS
  Combined color and power Doppler US and SWA may enable assessment of vascular architecture and altered flow of musculoskeletal tumors. Vascular architecture analysis enables differentiation of benign and malignant lesions and evaluation of musculoskeletal tumors.
authors: Department of Radiology, University Hospital of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. gerd.bodner@uibk.ac.at
authors: Gerd
authors: G
authors: Bodner
authors: Michael F H
authors: MF
authors: Schocke
authors: Franz
authors: F
authors: Rachbauer
authors: Klaus
authors: K
authors: Seppi
authors: Siegfried
authors: S
authors: Peer
authors: Anke
authors: A
authors: Fierlinger
authors: Tarek
authors: T
authors: Sununu
authors: Werner R
authors: WR
authors: Jaschke
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D016009:Chi-Square Distribution; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler / Q000379:methods*; D018615:Ultrasonography, Doppler, Color