[Effect of almitrine/raubasine on cerebral metabolism in the elderly].
Recent neurobiological data has led to renewed interest in oxygen (O2). The discovery of neuroglobin, protein varyingly present in the brain, has been enhanced by the elucidation of the mechanisms through which oxygen intervenes in neuronal metabolism. Almitrine/raubasine activates the metabolism of hypoxic/ischemic neurones by increasing O2 bioavailability. This mechanism supports the effects on behaviour obtained in various animal models and the benefits observed during clinical trials in elderly patients presenting with cognitive defects.
Allain
H
H
Laboratoire de Pharmacologie Expérimentale et Clinique Faculté de Médecine, Université de Rennes 1 2, avenue du Professeur Léon Bernard CS34317 35043 Rennes. Herve.Allain@univ-rennes1.fr
Bentué-Ferrer
D
D
D000368:Aged; D015765:Almitrine / Q000009:adverse effects / Q000627:therapeutic use*; D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002545:Brain Ischemia / Q000188:drug therapy; D004734:Energy Metabolism / Q000187:drug effects*; D006801:Humans; D009474:Neurons / Q000187:drug effects; D018697:Nootropic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D010101:Oxygen Consumption / Q000187:drug effects; D046948:Secologanin Tryptamine Alkaloids; D015016:Yohimbine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use*
D018697:Nootropic Agents; D046948:Secologanin Tryptamine Alkaloids; D015016:Yohimbine; C005709:raubasine; D015765:Almitrine