[Detection of serum free insulin-like growth factor 1 in patients with chronic viral hepatitis].
OBJECTIVE
To evaluate the serum free insulin-like growth factor 1 (IGF-1) level and its relation with the severity and prognosis in patients with chronic viral hepatitis, liver cirrhosis and severe chronic hepatitis.


METHODS
Serum free IGF-1 was detected by ELISA in 43 patients with chronic viral hepatitis, 20 with liver cirrhosis and 12 with chronic severe hepatitis.


RESULTS
Serum free IGF-1 was significantly decreased in patients with liver cirrhosis and severe chronic hepatitis. Five patients with chronic severe hepatitis whose serum free IGF-1 was lower than 0.2 ng/l died during follow-up. Four patients whose serum free IGF-1 above 0.3 ng/l survived. Serum free IGF-1 was significantly reduced in patients with albumin lower than 30 g/l.


CONCLUSIONS
Serum free IGF-1 is decreased in patients with liver cirrhosis and severe chronic hepatitis and it can predict the prognosis of patients with severe chronic hepatitis.
Lou
M
M
The 302nd Hospital of PLA, Beijing 100039, China.
Song
N
N
Jin
X
X
Luo
S Q
SQ
Wang
J J
JJ
D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006521:Hepatitis, Chronic / Q000097:blood*; D006525:Hepatitis, Viral, Human / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D008875:Middle Aged
D007334:Insulin-Like Growth Factor I