title: Clinical and radiographic evaluation of periodontal intrabony defects treated with guided tissue regeneration. A pilot study.
abstract: BACKGROUND
  The aim of this clinical and radiographic study was to evaluate the effect of guided tissue regeneration using a bioabsorbable barrier in the treatment of intrabony defects in humans.
  
  
  METHODS
  Intrabony osseous defects (2 or 3 walls) around mandibular canines and premolars were treated in 10 systemically healthy patients with ages ranging from 35 to 56 years. Prior to the surgical phase, patients were enrolled in a strict maintenance program including oral hygiene instructions and scaling and root planing (presurgical Pi and GI < 10%). Patients were seen for professional prophylaxis during the duration of the study. Clinical measurements were performed with an electronic probe at baseline and at reentry 8 months following surgical therapy. Measurements included clinical attachment levels (CAL), gingival margin levels (GML), probing depths (PD), bone defect levels (BDL), and alveolar crest level (ACL). A split mouth design was used. Quadrants were randomly assigned for treatment by GTR (experimental) or open flap debridement alone (control). Standardized radiographs were taken at baseline and at reentry. Digital images were analyzed by subtraction to assess changes in area (A) and optical density (OD). Data were evaluated using paired t test.
  
  
  RESULTS
  Statistically significant differences were found in both groups when comparing baseline and post-treatment values for CAL, GML, PD, and BDL (P < 0.0 1). Greater reductions in BDL and gain in A and OD were observed in the GTR group when compared to control (P < 0.01). Both therapies were effective in improving the clinical parameters assessed.
  
  
  CONCLUSIONS
  Clinical and radiographic findings from this study demonstrated more bone fill in sites treated with GTR.
authors: Department of Prosthodontics and Periodontics, School of Dentistry of Piracicaba, University of Campinas, São Paulo, Brazil.
authors: Julio Cesar
authors: JC
authors: Joly
authors: Daniela Bazan
authors: DB
authors: Palioto
authors: Antonio Fernando Martorelli
authors: AF
authors: de Lima
authors: Luis Fernando
authors: LF
authors: Mota
authors: Raul
authors: R
authors: Caffesse
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D016301:Alveolar Bone Loss / Q000145:classification / Q000000981:diagnostic imaging / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging / Q000473:pathology; D001641:Bicuspid / Q000601:surgery; D003481:Cuspid / Q000601:surgery; D003646:Debridement; D012534:Dental Scaling; D005500:Follow-Up Studies; D005888:Gingival Pocket / Q000145:classification / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000295:instrumentation; D006801:Humans; D008334:Mandible / Q000601:surgery; D008567:Membranes, Artificial; D008875:Middle Aged; D009910:Oral Hygiene; D017622:Periodontal Attachment Loss / Q000145:classification / Q000601:surgery; D010514:Periodontal Pocket / Q000145:classification / Q000601:surgery; D010865:Pilot Projects; D011856:Radiographic Image Enhancement; D016745:Root Planing; D016037:Single-Blind Method; D013223:Statistics as Topic; D013382:Subtraction Technique; D013524:Surgical Flaps
chemical_list: D008567:Membranes, Artificial