Physical performance, toxicity, and quality of life as assessed by the physician and the patient.
The aim of this study was to study the relationship between physician-assessed quality of life parameters, i.e., toxicity and physical performance, and patients' self-reports of their quality of life (QoL). QoL was assessed at baseline and before each treatment, using the EORTC QLQ-C30. The WHO performance score (PS) and toxicity were assessed in physician interviews. The correlations between the WHO PS and the QLQ-C30 functioning scale scores varied from weak to moderate, depending on the scale. Strongest associations were found in physical-, social-, and role functioning, and in the global QoL. The QLQ-C30 nausea/vomiting and diarrhea scales correlated moderately to corresponding WHO scores. A multiple linear regression analysis was used to analyze the contribution of WHO PS and toxicity variables to the global QoL. The best model explained only 16% of the variance of the global QoL score. The present findings highlight the importance of independent QoL assessments focused on those aspects of QoL not captured in clinical interviews with the physician.
Luoma
Minna-Liisa
ML
Department of Psychology, University of Helsinki, Finland. minna-liisa.luoma@helsinki.fi
Hakamies-Blomqvist
Liisa
L
Sjöström
Johanna
J
Mouridsen
Hennig
H
Pluzanska
Anna
A
Malmström
Per
P
Bengtsson
Nils Olof
NO
Hultborn
Ragnar
R
Ostenstaad
Björn
B
Mjaaland
Ingvil
I
Valvere
Vahur
V
Wist
Erik
E
Baldursson
Gudjon
G
Ahigren
Johan
J
Blomqvist
Carl
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000523:psychology*; D003967:Diarrhea / Q000139:chemically induced; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care; D010809:Physical Fitness; D011788:Quality of Life; D012647:Self-Assessment; D011795:Surveys and Questionnaires
D000903:Antibiotics, Antineoplastic; D005472:Fluorouracil; D008727:Methotrexate