Chiral recognition of functionalized cyclodextrins in capillary electrophoresis.
The chiral recognition of hydroxypropylated, dimethylated, and sulfated cyclodextrins was evaluated by utilizing them as chiral additives in capillary electrophoresis. Although each selector yielded enantiomeric separations of most of the target analytes, differences were observed in the electrophoretic results for the different derivatized cyclodextrins and for additives having varying degrees of substitution. The results for the sulfated cyclodextrins also highlighted the importance of knowing the degree of substitution as well as the location of the substituents when comparing chiral selectors.
Phinney
Karen W
KW
Analytical Chemistry Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899-8392, USA. karen.phinney@nist.gov
Jackson
John W
JW
Sander
Lane C
LC
D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D003505:Cyclodextrins / Q000737:chemistry* / Q000592:standards; D009930:Organic Chemicals / Q000302:isolation & purification; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D003505:Cyclodextrins; D009930:Organic Chemicals