[ABO/H blood groups and factor V Leiden].
BACKGROUND
Jick and his co-workers published in 1969 an observation showing the prevalence of blood group 0 being lower in people with thrombosis than in the healthy population. During the next years this finding was several times confirmed. The aim of our work was to answer the question on the distribution of blood groups in individuals with thrombophilia compared to the control group and whether the non-0 blood group increases the thrombosis risk in factor V Leiden carriers. We were also interested in mean values of the ProC Global test in different blood groups.


RESULTS
Factor V Leiden, prothrombin mutation 20210A and ProC Global were examined in individuals with thrombophilia. The blood group distribution was compared in thrombophilia and control groups. The distribution was statistically different (p = 0.000). The mean value of ProC Global in the non-0 carriers was lower than in persons with blood group 0.


CONCLUSIONS
There is a 1.76 times higher thrombosis risk (1/0.5697 = 1.76) in factor V Leiden carriers with blood group non-0 compared to blood group 0. The ProC Global mean values differ in patients with blood group 0 and in non-0 persons.
Matýsková
M
M
Oddĕlení klinické hematologie FN, Brno. mmatys@fnbrno.cz
Zavrelová
J
J
Pejchalová
A
A
Meluzinová
H
H
Janků
L
L
D000017:ABO Blood-Group System; D020016:Activated Protein C Resistance / Q000150:complications; D000328:Adult; D005165:Factor V / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D017354:Point Mutation; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D019851:Thrombophilia / Q000097:blood; D013927:Thrombosis / Q000097:blood* / Q000150:complications / Q000235:genetics
D000017:ABO Blood-Group System; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin