Cocaine-induced suppression of saccharin intake: a model of drug-induced devaluation of natural rewards.
In Experiment 1, water-deprived Sprague-Dawley rats were given 5 min access to saccharin. This tube retracted, an empty tube advanced, and the rats were given 1 hr to lick the empty tube on a fixed-ratio 10 lick contingency to self-administer saline or cocaine (0.33 mg/infusion) via an intravenous catheter. The results showed that rats avoided intake of saccharin after saccharin-cocaine pairings and that greater avoidance of the gustatory cue was associated with greater cocaine self-administration. In Experiment 2, a similar dose-response function was obtained with either the empty tube or a lever as the operant. In Experiment 3, avoidance of the saccharin cue and the propensity to self-administer cocaine were maintained after at least 1 month of abstinence. As such, this paradigm may be useful as a model of cue-induced craving and drug-induced devaluation of natural rewards.
Grigson
Patricia Sue
PS
Department of Behavioral Science, Pennsylvania State University College of Medicine, Hershey 17033, USA. psg6@psu.edu
Twining
Robert C
RC
D000284:Administration, Oral; D000818:Animals; D002408:Catheters, Indwelling; D003042:Cocaine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects; D003463:Cues; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D012201:Reward; D012439:Saccharin / Q000008:administration & dosage*; D012646:Self Administration; D013649:Taste / Q000187:drug effects
D018765:Dopamine Uptake Inhibitors; D012439:Saccharin; D003042:Cocaine