Tracking T cells with tetramers: new tales from new tools.
To understand the success or failure of immune responses against pathogens or tumours requires the direct measurement of specific lymphocytes. Recently, there has been an explosion of data in this field through the use of several new tools for measuring the number and function of T cells. This has allowed immunologists who study human disease and mouse models of infection and cancer to readily track specific T cells--in both time and space. Although there are common patterns, over time, each host-pathogen relationship seems to develop unique characteristics, as reflected in the quality of the T-cell response.
Klenerman
Paul
P
Nuffield Department of Medicine, University of Oxford, UK. klener@molbiol.ox.ac.uk
Cerundolo
Vincenzo
V
Dunbar
P Rod
PR
D000818:Animals; D004195:Disease Models, Animal; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007202:Indicators and Reagents; D018655:Lymphocyte Count; D046911:Macromolecular Substances; D009369:Neoplasms / Q000276:immunology*; D010455:Peptides / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D019809:Streptavidin; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000276:immunology
D015395:Histocompatibility Antigens Class I; D007202:Indicators and Reagents; D046911:Macromolecular Substances; D010455:Peptides; D011948:Receptors, Antigen, T-Cell; D001613:beta 2-Microglobulin; D019809:Streptavidin