title: Basal ganglia volumes in first-episode schizophrenia and healthy comparison subjects.
abstract: BACKGROUND
  Previous studies suggest that dysfunction of cortico-striato-pallido-thalamic (CSPT) circuitry may be involved in the pathophysiology of schizophrenia but also show that basal ganglia structure is highly plastic and may be influenced by antipsychotic treatments. Controversy remains about whether basal ganglia pathology can be detected in vivo among treatment-naïve patients. We conducted a magnetic resonance imaging (MRI) study to examine basal ganglia structures and the limbic forebrain in first episode schizophrenia and healthy comparison subjects.
  
  
  METHODS
  Fifty-one patients with first-episode schizophrenia and 28 healthy comparison subjects participated in the study. A high-resolution, special contrast (white matter nulling) MRI sequence was used to measure the caudate nucleus, nucleus accumbens, putamen, and subcommissural limbic forebrain.
  
  
  RESULTS
  Volumes of the basal ganglia regions of interest (adjusted for total brain volume and age) did not differ significantly between the groups. Age correlated significantly with caudate and putamen volumes bilaterally in the healthy comparison group, but not among patients.
  
  
  CONCLUSIONS
  The findings suggest that there are no volumetric abnormalities in basal ganglia before treatment in first-episode schizophrenia. The lack of a negative correlation between age and striatal volume among patients may implicate illness-associated factors that alter normal age-related changes in basal ganglia size.
authors: Department of Psychiatry Research, Hillside Hospital of the North Shore, Long Island Jewish Health System, 75-59 263rd Street, Glen Oaks, NY 11004, USA.
authors: Handan
authors: H
authors: Gunduz
authors: Huwei
authors: H
authors: Wu
authors: Manzar
authors: M
authors: Ashtari
authors: Bernhard
authors: B
authors: Bogerts
authors: David
authors: D
authors: Crandall
authors: Delbert G
authors: DG
authors: Robinson
authors: Jose
authors: J
authors: Alvir
authors: Jeffrey
authors: J
authors: Lieberman
authors: John
authors: J
authors: Kane
authors: Robert
authors: R
authors: Bilder
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000002:abnormalities*; D002421:Caudate Nucleus / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009714:Nucleus Accumbens / Q000033:anatomy & histology; D016548:Prosencephalon / Q000002:abnormalities; D011569:Psychiatric Status Rating Scales; D011699:Putamen / Q000033:anatomy & histology; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*