Do defects in ion channel glycosylation set the stage for lethal cardiac arrhythmias?
Many ion channels are modified by the addition of carbohydrate residues. Fozzard and Kyle discuss evidence that sialic acid residues on glycosylated cardiac sodium and potassium channels may be important for preventing early after-depolarizations that can result in cardiac arrhythmias.
Fozzard
Harry A
HA
Cardiac Electrophysiology Laboratories, Departments of Medicine and of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, IL 60637, USA. foz@hearts.bsd.uchicago.edu
Kyle
John W
JW
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D016757:Death, Sudden, Cardiac / Q000209:etiology* / Q000473:pathology; D004195:Disease Models, Animal; D006031:Glycosylation; D006801:Humans; D007473:Ion Channels / Q000235:genetics* / Q000378:metabolism* / Q000502:physiology; D008133:Long QT Syndrome / Q000235:genetics / Q000503:physiopathology
D007473:Ion Channels