[Metformin. Mode of action and effect of monotherapy and combination therapy on glucose metabolism in type 2 diabetes].
The aim of the review is to give a short presentation of the pharmacological properties and effectiveness of metformin. Existing evidence for the clinical use of metformin, both in monotherapy and in combination with other classes of anti-diabetics, is discussed. Overall, metformin presents a very favourable profile in the treatment of type 2 diabetes.
Christiansen
Allan Lindskov
AL
H:S Hvidovre Hospital, medicinsk endokrinologisk afdeling.
Madsbad
Sten
S
D020909:Acarbose / Q000008:administration & dosage; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D007328:Insulin / Q000008:administration & dosage; D008687:Metformin / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D013844:Thiazoles / Q000008:administration & dosage; D016896:Treatment Outcome
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D013844:Thiazoles; D008687:Metformin; D020909:Acarbose