Diphyllin acetylapioside, a 5-lipoxygenase inhibitor from Haplophyllum hispanicum.
The topical anti-inflammatory activity of Haplophyllum hispanicum Spach is due to the presence of arylnaphthalene-type lignans acting as 5-lipoxygenase (5-LOX) inhibitors. The effects of the methanolic extract of this species on cellular systems have been determined by HPLC-DAD analysis. Diphyllin acetylapioside proved to be the main lignan endowed with 5-LOX inhibitory activity.
Prieto
José Ma
JM
Giner
Rosa Ma
RM
Recio Mf
Ma Carmen
MC
Schinella
Guillermo
G
Máñez
Salvador
S
Ríos
José Luis
JL
D001092:Arachidonate 12-Lipoxygenase / Q000187:drug effects / Q000378:metabolism; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D051545:Cyclooxygenase 1; D004148:Dioxolanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007527:Isoenzymes / Q000187:drug effects / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects / Q000378:metabolism
D004148:Dioxolanes; D006027:Glycosides; D007527:Isoenzymes; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; C103139:tuberculatin; C103138:diphyllin acetyl apioside; D001092:Arachidonate 12-Lipoxygenase; D001094:Arachidonate 5-Lipoxygenase; D051545:Cyclooxygenase 1; D011451:Prostaglandin-Endoperoxide Synthases