title: Clinical, microscopic, and molecular aspects of canine leproid granuloma in the United States.
abstract: Leproid granulomas from seven dogs in the United States were evaluated. Gross characteristics included nodular and ulcerated dermal and subcutaneous lesions primarily on the caudal aspects of the pinnae and to a lesser extent on the muzzle, face, and forelimbs. In all except one dog, there was complete regression of the lesions within 6 months, either with no therapy or after surgical resection. Cytology or histopathology revealed pyogranulomatous inflammation with few to many acid-fast mycobacterial bacilli within macrophages. The organisms could not be cultivated in vitro. DNA sequencing of part of the 16S ribosomal RNA gene region revealed 99-100% homology among fragments from five of these dogs and fragments from dogs in the south Pacific. This syndrome occurs in dogs in North America and the prognosis is excellent, in contrast to the prognosis for rapid-growing or tuberculous mycobacteriosis.
authors: Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis 95616, USA.
authors: J E
authors: JE
authors: Foley
authors: D
authors: D
authors: Borjesson
authors: T L
authors: TL
authors: Gross
authors: C
authors: C
authors: Rand
authors: M
authors: M
authors: Needham
authors: A
authors: A
authors: Poland
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000382:microbiology / Q000473:pathology*; D004285:Dogs; D005260:Female; D006099:Granuloma / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009161:Mycobacterium / Q000235:genetics / Q000302:isolation & purification; D009164:Mycobacterium Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011379:Prognosis; D012336:RNA, Ribosomal, 16S / Q000032:analysis; D017192:Skin Diseases, Bacterial / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*
chemical_list: D012336:RNA, Ribosomal, 16S