title: Buckwheat extract inhibits progression of renal failure.
abstract: Rats subjected to partial resection of the parenchyma showed reduced radical-scavenging activity in the remaining kidney and increased severity of renal tissue lesions. However, in similarly nephrectomized rats given buckwheat extract, the state of oxidative stress improved by restoring the decreased activities of reactive oxygen species-scavenging enzymes such as superoxide dismutase and catalase. The degree of mesangial proliferation, severity of extratubular lesions such as crescents and adhesions, glomerulosclerosis index, and severity of tubular interstitial lesions also improved. In addition, nephrectomized rats given buckwheat extract showed improvement in renal function, as indicated by decreased serum level of creatinine, with a significant decrease in the level of methylguanidine, a uremic toxin produced from creatinine in the presence of hydroxyl radical.
authors: Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan. yokozawa@ms.toyama-mpu.ac.jp
authors: Takako
authors: T
authors: Yokozawa
authors: Hyun Young
authors: HY
authors: Kim
authors: Gen-Ichiro
authors: G
authors: Nonaka
authors: Kenichi
authors: K
authors: Kosuna
mesh_terms: D000818:Animals; D019612:Fagopyrum / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006146:Guanidines / Q000032:analysis; D007668:Kidney / Q000201:enzymology; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D009392:Nephrectomy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D051437:Renal Insufficiency / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D006146:Guanidines; D010936:Plant Extracts; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase