Reduction of 1-methyl-1-nitrosourea-induced mammary gland carcinoma by in vivo application of immunostimulatory CpG motifs in Sprague-Dawley rats.
In the present work the role of 13-cis retinoic acid and CpG oligodeoxynucleotides (CpG-ODN) in a 1-methyl-1-nitrosourea (MNU)-induced mammary gland carcinoma animal model was investigated. Treatment with both components, applied either alone or in combination, induced a significant decrease of the tumour burden and the volume of tumours only in rats that received CpG-ODN (p = 0.046, compared to the MNU control group). The data indicate that the Th-1 biased immunostimulatory capacities of CpG motifs may play a significant role in induction of protective immune responses against mammary gland tumours in Sprague-Dawley rats.
Macejová
D
D
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
Dvorcakova
M
M
Weiss
R
R
Scheiblhofer
S
S
Mostböck
S
S
Líska
J
J
Szabová
E
E
Zórad
S
S
Thalhamer
J
J
Brtko
J
J
D000477:Alkylating Agents / Q000494:pharmacology; D020816:Amino Acid Motifs; D000818:Animals; D002273:Carcinogens; D018899:CpG Islands; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000139:chemically induced*; D008770:Methylnitrosourea; D015233:Models, Statistical; D009374:Neoplasms, Experimental / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014212:Tretinoin / Q000494:pharmacology
D000477:Alkylating Agents; D002273:Carcinogens; D014212:Tretinoin; D008770:Methylnitrosourea