title: Bergenin is the antiarrhythmic principle of Fluggea virosa.
abstract: Bergenin was isolated from the aerial parts of Fluggea virosa (Euphorbiaceae). Its structure was elucidated on the basis of chemical and spectral data. Anti-arrhythmic effects of bergenin were investigated. At concentrations of 0.2 mg/kg, 0.4 mg/kg, and 0.8 mg/kg, bergenin showed distinct therapeutic effects on BaCl2-induced arrhythmias in rats. At concentrations of 0.4 mg/kg and 0.8 mg/kg bergenin significantly countered arrhythmias induced by ligation and reperfusion of the coronary artery. At 0.8 mg/kg, bergenin elevated the atria fibrillation threshold in rabbits from 1.34 mV to 1.92 mV. Our results suggest that bergenin has good potential to treat cardiac arrhythmias.
authors: Han-Lin
authors: HL
authors: Pu
authors: Xia
authors: X
authors: Huang
authors: Jin-Hua
authors: JH
authors: Zhao
authors: An
authors: A
authors: Hong
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D017609:Barium Compounds; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002712:Chlorides; D003331:Coronary Vessels / Q000187:drug effects / Q000503:physiopathology; D019665:Euphorbiaceae; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000889:Anti-Arrhythmia Agents; D017609:Barium Compounds; D001578:Benzopyrans; D002712:Chlorides; D010936:Plant Extracts; C024986:barium chloride; C006741:bergenin