title: Inhibition of vascular endothelial growth factor expression and production by triptolide.
abstract: Triptolide, the major component of the diterpenoids of the Chinese herb Tripterygium wilfordii Hook f. (Celastraceae), inhibited vascular endothelial growth factor expression and secretion in endothelial cells treated by 12-O-tetradecanoylphorbol 13-acetate dose-dependently. This effect may be one of the mechanisms underlying the therapeutic effects of triptolide on rheumatoid arthritis.
authors: Ke-Bin
authors: KB
authors: Hu
authors: Zhi-Hong
authors: ZH
authors: Liu
authors: Dong
authors: D
authors: Liu
authors: Lei-Shi
authors: LS
authors: Li
mesh_terms: D029753:Celastraceae; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D016228:Endothelial Growth Factors / Q000235:genetics / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004852:Epoxy Compounds; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008222:Lymphokines / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D010616:Phenanthrenes; D010936:Plant Extracts / Q000494:pharmacology; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D004224:Diterpenes; D016228:Endothelial Growth Factors; D004852:Epoxy Compounds; D008222:Lymphokines; D010616:Phenanthrenes; D010936:Plant Extracts; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; C001899:triptolide; D013755:Tetradecanoylphorbol Acetate