title: Manipulating chemoattractant and receptor genes.
abstract: Chemoattractants, including classical chemotactic factors and members of the chemokine superfamily, function as inducers of leukocyte trafficking and activation based on interactions with seven transmembrane (STM), G protein-coupled receptors. These molecules are expressed by many cell types either constitutively or upon stimulation. Considerable knowledge about the pathophysiological role of chemoattractants and their receptors has been accumulated during the past two decades. However, recent studies using transgenic and gene targeting technology have provided a better illustration of the importance and complexity of the involvement of chemoattractants and receptors in leukocyte trafficking, inflammation, infection, immune responses, development, angiogenesis/angiostasis, and malignant tumors.
authors: Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
authors: Yingying
authors: Y
authors: Le
authors: Youhong
authors: Y
authors: Cui
authors: Pablo
authors: P
authors: Iribarren
authors: Guoguang
authors: G
authors: Ying
authors: Ji Ming
authors: JM
authors: Wang
mesh_terms: D000818:Animals; D002630:Chemotactic Factors / Q000235:genetics*; D018390:Gene Targeting; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D023421:Models, Animal; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic / Q000235:genetics*; D018000:Receptors, Peptide / Q000235:genetics*; D019076:Transgenes
chemical_list: D002630:Chemotactic Factors; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic; D018000:Receptors, Peptide