title: [Polymorphism analysis of 825C/T of the G-protein beta 3 subunit in high risk population of hypertension in the northeast China].
abstract: PCR-RFLP was used for genotyping of GNB3 C/T in 133 patients with EH and 257 healthy control subjects in the high risk population and in 98 patients with EH and 110 healthy control subjects in general population. Some biochemical tests were performed also. The association between the polymorphism and blood pressure was analyzed by the case-control study. Not association between GNB3 825C/T polymorphism and blood pressure was found in both populations. CT and TT genotypes in women of the high risk population are associated with diastolic blood pressure, serum sodium and calcium. Although GNB3 is not a susceptible gene of hypertension in the northeast Chinese, it still has some effects on regulation of the blood pressure in susceptible women.
authors: Department of Medical Genetics, China Medical University, Shenyang 110001, China.
authors: Shu-Ping
authors: SP
authors: Dai
authors: Jing-Pu
authors: JP
authors: Shi
authors: Qian
authors: Q
authors: Ding
authors: Hai-Long
authors: HL
authors: Wang
authors: Ling-Yue
authors: LY
authors: Dong
authors: Di
authors: D
authors: Sun
authors: Kai
authors: K
authors: Fang
authors: Yan-Yan
authors: YY
authors: Zhao
mesh_terms: D005260:Female; D020022:Genetic Predisposition to Disease; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D020962:Heterotrimeric GTP-Binding Proteins