p53, apoptosis and radiosensitivity--experimental and clinical data.
The tumor suppressor gene p53 is the most frequently mutated gene found in human tumors. The p53 protein is a central regulator of the cell cycle and of the induction of apoptosis after genotoxic stress, e.g. due to radiation or drugs. p53 functions mainly through transcriptional control triggered by DNA damage and influences multiple response pathways. Because of this important role in the response of cells to radiation, the interrelation between p53 status and radiosensitivity has found wide interest. Experimental and clinical data are discussed to explain the mechanism by which p53 influences the cellular response to radiation and to demonstrate the clinical relevance.
Weber
K J
KJ
Strahlenbiologisches Labor, Abteilung Klinische Radiologie, Universitätsklinikum Mannheim, Universität Heidelberg, Germany.
Wenz
F
F
D000818:Animals; D017209:Apoptosis / Q000235:genetics* / Q000528:radiation effects; D002470:Cell Survival / Q000235:genetics* / Q000528:radiation effects; D002986:Clinical Trials as Topic; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000532:radiotherapy*; D011379:Prognosis; D014407:Tumor Cells, Cultured / Q000528:radiation effects*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53