Effects of uncontrolled seizures. Neural changes in animal models.
Doctors Stafstrom and Holmes have spent several years studying the brain damage and behavioral deficits caused by repeated seizures or status epilepticus. They discuss possible mechanisms and the effects of age.
Stafstrom
Carl E
CE
Division of Clinical Neurophysiology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Holmes
Gregory L
GL
D000818:Animals; D001921:Brain / Q000473:pathology*; D001923:Brain Chemistry; D002648:Child; D004195:Disease Models, Animal; D006801:Humans; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D012008:Recurrence; D012640:Seizures / Q000378:metabolism / Q000473:pathology*