The core structure of the lipopolysaccharide from the causative agent of plague, Yersinia pestis.
The rough-type lipopolysaccharide (LPS) of the plague pathogen, Yersinia pestis, was studied after mild-acid and strong-alkaline degradations by chemical analyses, NMR spectroscopy and electrospray-ionization mass spectrometry, and the following structure of the core region was determined:where L-alpha-D-Hep stands for L-glycero-alpha-D-manno-heptose, Sug1 for either 3-deoxy-alpha-D-manno-oct-2-ulosonic acid (alpha-Kdo) or D-glycero-alpha-D-talo-oct-2-ulosonic acid (alpha-Ko), and Sug2 for either beta-D-galactose or D-glycero-alpha-D-manno-heptose. A minority of the LPS molecules lacks GlcNAc.
Vinogradov
Evgeny V
EV
N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospekt 47,Moscow 119991, Russia.
Lindner
Buko
B
Kocharova
Nina A
NA
Senchenkova
Sof'ya N
SN
Shashkov
Aleksander S
AS
Knirel
Yuriy A
YA
Holst
Otto
O
Gremyakova
Tat'yana A
TA
Shaikhutdinova
Rima Z
RZ
Anisimov
Andrei P
AP
D002240:Carbohydrate Sequence; D008070:Lipopolysaccharides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry; D010930:Plague / Q000382:microbiology; D021241:Spectrometry, Mass, Electrospray Ionization; D015010:Yersinia pestis / Q000737:chemistry*
D008070:Lipopolysaccharides; D009844:Oligosaccharides