[A short tandem repeat polymorphism in the inducible nitric oxide synthase gene in Chinese population].
Polymorphism of the (CCTTT)n repeat, a short tandem repeats (STR) located in promoter region of the inducible nitric oxide synthase (iNOS) gene, was analyzed in a total of 316 Chinese healthy subjects. Twelve alleles and forty-nine genotypes were identified. Three alleles that had not been reported previously, namely 17-repeats, 18-repeats and 19-repeats, were found in Chinese population. Mendelian inheritance of the allele in a family composed of three generations was determined. Some of the observed allele frequency of this STR locus in Chinese differed significantly from that of Caucasians in England.
Lü
Xing
X
Department of Biochemistry & Molecular Biology, Institute of Radiation Medicine, Beijing 100850, China. lvx@nic.bmi.ac.cn
Lu
Ping
P
Xing
Rui-Yun
RY
Sun
Qi-Yun
QY
Qiu
Ze-Wu
ZW
Han
Li
L
Zhou
Xu-Bin
XB
Zheng
Xiao-Fei
XF
D000293:Adolescent; D000328:Adult; D000483:Alleles; D001483:Base Sequence; D002681:China / Q000208:ethnology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052247:Nitric Oxide Synthase Type II; D011110:Polymorphism, Genetic; D020080:Tandem Repeat Sequences; D044465:White People
C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II