title: Genetic network of the eye in Platyhelminthes: expression and functional analysis of some players during planarian regeneration.
abstract: Planarians are the free-living members (order Tricladida) of the phylum Platyhelminthes. They are triploblastic, acoelomate, unsegmented and located at the base of the Lophotrochozoa clade. Besides their huge regenerative capacity, planarians have simple eyes, considered similar to the prototypic eye suggested by Charles Darwin in his book 'On the Origin of Species'. The conserved genetic network that determines the initial steps of eye development across metazoans supports a monophyletic origin of the various eye types present in the animal kingdom. Here we summarise the pattern of expression of certain genes involved in the eye network that have been isolated in planarians, such as Otx, Pax-6, Six, Rax and opsin. We describe the effects of RNA interference-mediated loss of function on eye regeneration. Finally, we discuss the relevance of these findings for the evolution of the eye gene network.
authors: Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, E-08071 Barcelona, Spain. esalo@porthos.bio.ub.es
authors: Emili
authors: E
authors: Saló
authors: David
authors: D
authors: Pineda
authors: Maria
authors: M
authors: Marsal
authors: Javier
authors: J
authors: Gonzalez
authors: Vittorio
authors: V
authors: Gremigni
authors: Renata
authors: R
authors: Batistoni
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005123:Eye / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D017238:Genes, Helminth / Q000235:genetics; D006257:Head / Q000502:physiology; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D010641:Phenotype; D010986:Platyhelminths / Q000235:genetics* / Q000254:growth & development; D012330:RNA, Double-Stranded / Q000235:genetics; D012038:Regeneration / Q000235:genetics; D017386:Sequence Homology, Amino Acid
chemical_list: D012330:RNA, Double-Stranded