Carbamazepine-induced acute granulomatous interstitial nephritis.
A 79-year-old man, newly started on carbamazepine, presented with rash, eosinophilia and liver dysfunction progressing to acute renal failure despite discontinuation of the anti-epileptic agent. Percutaneous renal biopsy revealed acute granulomatous interstitial nephritis, which responded successfully to high-dose oral steroid therapy.
Hegarty
J
J
Department of Renal Medicine, Hope Hospital, Salford, UK. jan.hegarty@ticketbox.net
Picton
M
M
Agarwal
G
G
Pramanik
A
A
Kalra
P A
PA
D000208:Acute Disease; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D001706:Biopsy; D002220:Carbamazepine / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis; D006099:Granuloma / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced*
D000927:Anticonvulsants; D002220:Carbamazepine