[The research into functions of heme oxygenase system in brain].
Heme oxygenase(HO) is a microsomal enzyme involved in the degradation of heme, resulting in the generation of biliverdin, iron, and carbon monoxide. Two HO isoenzymes, HO-1 and HO-2, have been found to distribute widely in brain with different mechanism of regulation. Both of them may play important roles in modulating intracellular NO, balancing antioxidative/oxidative stress, and accelerating neurodegeneration.
Guo
Jian-Zeng
JZ
Department of Pharmacology, Chongqing University of Medical Sciences, Chongqing 400016.
Zhou
Qi-Xin
QX
D000818:Animals; D001921:Brain / Q000201:enzymology*; D006419:Heme Oxygenase (Decyclizing) / Q000502:physiology*; D051547:Heme Oxygenase-1; D006801:Humans; D007527:Isoenzymes / Q000502:physiology; D008565:Membrane Proteins
D007527:Isoenzymes; D008565:Membrane Proteins; C496541:HMOX1 protein, human; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; C105245:heme oxygenase-2