title: [Antineutrophil cytoplasmic antibodies (ANCA): clinico-pathologic correlations iin a series of 82 cases].
abstract: OBJECTIVE
  Antineutrophil cytoplasmic antibodies (ANCA) have been described in a great variety of diseases in addition to the ANCA-associated systemic vasculitis (Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg-Strauss syndrome (CSS)) and the pauci-immune rapidly progressive glomerulonephritis (RPGN). The objective of this work is to describe the clinical-pathological diagnosis of a series of patients with ANCA.
  
  
  METHODS
  Retrospective review of patients with positive ANCA by indirect immunofluorescence in our hospital between January 1997 and December 1998.
  
  
  RESULTS
  We identify 82 patients with ANCA. Six cases (7.3%) showed a C-ANCA pattern, 19 (23.2%) a P-ANCA pattern and 57 (69.5%) an atypical pattern. Eight patients (9.7%) had an ANCA-associated systemic vasculitis (5 WG, 2 MPA and 1 SCS). Four patients (4.9%) had a pauci-immune RPGN without systemic vasculitis. One only case (1.2%) in our series presented a C-ANCA pattern without evidence of an ANCA-associated systemic vasculitis or a pauci-immune RPGN.
  
  
  CONCLUSIONS
  The atypical pattern is the most frequent in patients with ANCA. A minority of patients with ANCA have an ANCA-associated systemic vasculitis (WG, MPA or SCS) or a pauci-immune RPGN. The occurrence of a C-ANCA pattern is exceptional in patients without an ANCA-associated systemic vasculitis or a pauci-immune RPGN.
authors: Servicio de Medicina Interna, Hospital Universitario Infanta Cristina, Badajoz.
authors: J M
authors: JM
authors: Calvo Romero
authors: J
authors: J
authors: Romero Requena
authors: J C
authors: JC
authors: Arévalo Lorido
authors: J L
authors: JL
authors: Ramos Salado
authors: E
authors: E
authors: Doblaré Castellano
authors: M L
authors: ML
authors: Vargas Pérez
authors: P
authors: P
authors: Bureo Dacal
authors: M
authors: M
authors: Pérez Miranda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic