[Mast cells and atherosclerosis].
Recent data indicate an important role of mast cell in the pathogenesis of atherosclerosis; especially the influence of biologically active substances derived from mast cells such as serine proteinases on metabolism of angiotensin, bradykinin and lipoproteins. The presence of mastocytes in the hinge region of atherosclerotic plaque seems to indicate their important role in plaque rupture and complications of fibrous plaque. Besides the many pathogenic effects of mastocytes they may participate in the maintenance of vascular wall integrity and regeneration. This article presents important aspects of the role of mast cells in pathogenesis of atherosclerosis.
Francuz
T
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Zakład Biochemii Doświadczalnej i Klinicznej Slaskiej Akademii Medycznej, 40-752 Katowice, ul. Medyków 18. tfrancuz@mp.pl
D000809:Angiotensins / Q000378:metabolism; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology* / Q000276:immunology / Q000378:metabolism*; D001920:Bradykinin / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D008407:Mast Cells / Q000276:immunology* / Q000473:pathology*; D008954:Models, Biological; D012307:Risk Factors; D012697:Serine Endopeptidases / Q000378:metabolism
D000809:Angiotensins; D008074:Lipoproteins; D012697:Serine Endopeptidases; D001920:Bradykinin