title: Hypodense eosinophils: characterization of surface molecule expression.
abstract: Distinct eosinophil populations have been characterized on the basis of discontinuous Percoll density gradients. In peripheral blood, normal individuals show a low number of normodense and hypodense eosinophils, contrasting with the high amount of hypodense cells in patients who have allergies. To characterize these two eosinophil populations, we analyzed membrane expression of several antigens and cytokine receptors in normodense and hypodense eosinophils from patients who have allergies and controls. Hypodense eosinophils expressed higher levels of CD122, CD69, and CD4 in both patients with allergies and control individuals when compared to normodense eosinophils. The expression of CD125, CD124, CD25, CD132, and CD23 were similar in both cell types.
authors: Institute of Immunology, Faculty of Medicine, Central University of Venezuela, Caracas, Venezuela.
authors: Angela
authors: A
authors: Conesa
authors: Paolo
authors: P
authors: Tassinari
authors: Henry
authors: H
authors: Rivera
authors: Juan B
authors: JB
authors: De Sanctis
authors: Nicolás
authors: N
authors: Bianco
authors: Oscar
authors: O
authors: Aldrey
mesh_terms: D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000032:analysis / Q000276:immunology; D000954:Antigens, Surface / Q000032:analysis* / Q000276:immunology; D001249:Asthma / Q000276:immunology* / Q000473:pathology*; D002452:Cell Count; D002499:Centrifugation, Density Gradient; D004804:Eosinophils / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D066298:In Vitro Techniques; D018121:Receptors, Cytokine / Q000032:analysis / Q000276:immunology; D018123:Receptors, Interleukin / Q000032:analysis / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D000954:Antigens, Surface; D018121:Receptors, Cytokine; D018123:Receptors, Interleukin