Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend.
Electrospun fiber mats are explored as drug delivery vehicles using tetracycline hydrochloride as a model drug. The mats were made either from poly(lactic acid) (PLA), poly(ethylene-co-vinyl acetate) (PEVA), or from a 50:50 blend of the two. The fibers were electrospun from chloroform solutions containing a small amount of methanol to solubilize the drug. The release of the tetracycline hydrochloride from these new drug delivery systems was followed by UV-VIS spectroscopy. Release profiles from the electrospun mats were compared to a commercially available drug delivery system, Actisite (Alza Corporation, Palo Alto, CA), as well as to cast films of the various formulations.
Kenawy
El-Refaie
el-R
Department of Chemical Engineering, Virginia Commonwealth University, Richmond, VA 23298, USA.
Bowlin
Gary L
GL
Mansfield
Kevin
K
Layman
John
J
Simpson
David G
DG
Sanders
Elliot H
EH
Wnek
Gary E
GE
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D004548:Elasticity; D019344:Lactic Acid / Q000493:pharmacokinetics*; D046911:Macromolecular Substances; D011091:Polyesters; D011108:Polymers / Q000493:pharmacokinetics*; D011145:Polyvinyls / Q000493:pharmacokinetics*; D055672:Static Electricity; D013752:Tetracycline / Q000493:pharmacokinetics*; D014783:Viscosity
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D046911:Macromolecular Substances; D011091:Polyesters; D011108:Polymers; D011145:Polyvinyls; C016438:ethylenevinylacetate copolymer; D019344:Lactic Acid; C033616:poly(lactide); D013752:Tetracycline