title: [Immune status of BALB/c mice and rubella virus JR23 strain infection of central nervous system].
abstract: BACKGROUND
  To investigate the relationship between immune status and rubella virus (RV) infection of central nervous system (CNS).
  
  
  METHODS
  BALB/c mice were given dexamethaxone and cytoxan before RV JR23 strain infection. Immune functions and RV invasion to CNS were assayed at 21 days postinfection via abdominal cavity and their relationship was analyzed.
  
  
  RESULTS
  T cell functions of cytoxan group were obviously worse than those of other groups (P <0.05) by MTT method. Infection rates of dexamethaxone and cytoxan and the group without any intervention were 60%, 90% and 50% (P >0.05), respectively. Cellular immune functions of the mice with CNS infection were obviously worse than those of the mice without CNS infection (P <0.001). Specific antibodies (Ab) were assayed in all groups with ELISA and the results showed that there were no significant differences among groups (P >0.05), neither between the groups with and without CNS infections.
  
  
  CONCLUSIONS
  RV infection of CNS may relate to cellular immune status before specific antibody was produced in the body.
authors: Department of Virology, Shandong Medical University, Jinan 250012, China.
authors: Zhiyu
authors: Z
authors: Wang
authors: Ping
authors: P
authors: Yao
authors: Yanyan
authors: Y
authors: Song
authors: Hongzhi
authors: H
authors: Xu
authors: Guiting
authors: G
authors: Wang
authors: Yanxun
authors: Y
authors: Liu
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D002494:Central Nervous System Infections / Q000276:immunology* / Q000821:virology; D005260:Female; D007111:Immunity, Cellular; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012409:Rubella / Q000276:immunology*; D012412:Rubella virus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology