title: A sequence-based map of the nine genes of the human interleukin-1 cluster.
abstract: Six novel genes encoding proteins with the interleukin (IL)-1 fold have been identified recently. The classical family members are involved in inflammatory signaling. Previous work has placed the novel genes close to or within the same cluster as IL1A, IL1B, and IL1RN, which occupy an approximately 400-kb interval on chromosome 2. We have combined the incomplete public database sequence with our own sequence to generate a reference sequence and map that encompass all of the novel genes, allowing determination of the gene structures, precise localization of exons, and determination of distances between conventional SNP and microsatellite markers. Gene order from centromere to telomere is IL1A-IL1B-IL1F7-IL1F9-IL1F6-IL1F8-IL1F5-IL1F10-IL1RN, of which only IL1A, IL1B, and IL1F8 are transcribed towards the centromere. The gene order relates to the evolutionary relationship between the genes. Key features of exon boundaries are conserved. There is no evidence for other IL-1 family members within the cluster.
authors: Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK. m.nicklin@shef.ac.uk
authors: Martin J H
authors: MJ
authors: Nicklin
authors: Jenny L
authors: JL
authors: Barton
authors: Minh
authors: M
authors: Nguyen
authors: Michael G
authors: MG
authors: FitzGerald
authors: Gordon W
authors: GW
authors: Duff
authors: Ken
authors: K
authors: Kornman
mesh_terms: D000595:Amino Acid Sequence; D002874:Chromosome Mapping / Q000379:methods*; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D018899:CpG Islands / Q000235:genetics; D023061:Gene Order; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D010802:Phylogeny; D011110:Polymorphism, Genetic; D017386:Sequence Homology, Amino Acid
chemical_list: D007375:Interleukin-1