title: Randomized trial of one versus two transcervical insertions of quinacrine pellets for sterilization.
abstract: OBJECTIVE
  To determine the relative effectiveness of single vs. two transcervical monthly insertions of 252 mg of quinacrine for female sterilization.
  
  
  METHODS
  Controlled clinical study.
  
  
  METHODS
  Family planning clinics of 6 academic centers.
  
  
  METHODS
  Sexually active reproductive-age women requesting sterilization.
  
  
  METHODS
  At each of six centers 70 and 30 women were randomly assigned to receive either one or two, respectively, monthly transcervical insertions to the fundus of 252 mg of quinacrine and 75 mg of diclofenac as pellets and they were followed for 1 year.
  
  
  METHODS
  Complications, side effects, and pregnancy failures.
  
  
  RESULTS
  There were no serious complications and side effects were transient and easily treated. There were 31 (7.4%) pregnancy failures in the single insertions group and 2 (1.1%) in the two insertions group, but with marked center variation.
  
  
  CONCLUSIONS
  Quinacrine sterilization using two monthly insertions of 252 mg of quinacrine appears safe and reasonably effective.
authors: Department of Obstetrics and Gynecology, Dr. Hasan Sadikin Hospital/Medical School, Padjadaran University, Bandung, Indonesia. dragias@bdg.centrin.net.id
authors: Tina
authors: T
authors: Agoestina
authors: R Hasan M
authors: RH
authors: Hoesni
authors: Benny Hasan
authors: BH
authors: Purwara
authors: Budi Iman
authors: BI
authors: Santoso
authors: Padjar
authors: P
authors: Siswanto
authors: Djaswadi
authors: D
authors: Dasuki
authors: A
authors: A
authors: Samsulhadi
authors: Gede Putu
authors: GP
authors: Surya
mesh_terms: D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D015993:Life Tables; D011247:Pregnancy; D018873:Pregnancy Rate; D011796:Quinacrine / Q000008:administration & dosage* / Q000009:adverse effects; D013246:Sterilization, Tubal / Q000379:methods; D016896:Treatment Outcome
chemical_list: D011796:Quinacrine