title: Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).
abstract: Streptomyces coelicolor is a representative of the group of soil-dwelling, filamentous bacteria responsible for producing most natural antibiotics used in human and veterinary medicine. Here we report the 8,667,507 base pair linear chromosome of this organism, containing the largest number of genes so far discovered in a bacterium. The 7,825 predicted genes include more than 20 clusters coding for known or predicted secondary metabolites. The genome contains an unprecedented proportion of regulatory genes, predominantly those likely to be involved in responses to external stimuli and stresses, and many duplicated gene sets that may represent 'tissue-specific' isoforms operating in different phases of colonial development, a unique situation for a bacterium. An ancient synteny was revealed between the central 'core' of the chromosome and the whole chromosome of pathogens Mycobacterium tuberculosis and Corynebacterium diphtheriae. The genome sequence will greatly increase our understanding of microbial life in the soil as well as aiding the generation of new drug candidates by genetic engineering.
authors: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. sdb@sanger.ac.uk
authors: S D
authors: SD
authors: Bentley
authors: K F
authors: KF
authors: Chater
authors: A-M
authors: AM
authors: Cerdeño-Tárraga
authors: G L
authors: GL
authors: Challis
authors: N R
authors: NR
authors: Thomson
authors: K D
authors: KD
authors: James
authors: D E
authors: DE
authors: Harris
authors: M A
authors: MA
authors: Quail
authors: H
authors: H
authors: Kieser
authors: D
authors: D
authors: Harper
authors: A
authors: A
authors: Bateman
authors: S
authors: S
authors: Brown
authors: G
authors: G
authors: Chandra
authors: C W
authors: CW
authors: Chen
authors: M
authors: M
authors: Collins
authors: A
authors: A
authors: Cronin
authors: A
authors: A
authors: Fraser
authors: A
authors: A
authors: Goble
authors: J
authors: J
authors: Hidalgo
authors: T
authors: T
authors: Hornsby
authors: S
authors: S
authors: Howarth
authors: C-H
authors: CH
authors: Huang
authors: T
authors: T
authors: Kieser
authors: L
authors: L
authors: Larke
authors: L
authors: L
authors: Murphy
authors: K
authors: K
authors: Oliver
authors: S
authors: S
authors: O'Neil
authors: E
authors: E
authors: Rabbinowitsch
authors: M-A
authors: MA
authors: Rajandream
authors: K
authors: K
authors: Rutherford
authors: S
authors: S
authors: Rutter
authors: K
authors: K
authors: Seeger
authors: D
authors: D
authors: Saunders
authors: S
authors: S
authors: Sharp
authors: R
authors: R
authors: Squares
authors: S
authors: S
authors: Squares
authors: K
authors: K
authors: Taylor
authors: T
authors: T
authors: Warren
authors: A
authors: A
authors: Wietzorrek
authors: J
authors: J
authors: Woodward
authors: B G
authors: BG
authors: Barrell
authors: J
authors: J
authors: Parkhill
authors: D A
authors: DA
authors: Hopwood
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D002876:Chromosomes, Bacterial / Q000235:genetics; D003353:Corynebacterium diphtheriae / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics*; D020131:Genes, Duplicate / Q000235:genetics; D016680:Genome, Bacterial; D023281:Genomics; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D009169:Mycobacterium tuberculosis / Q000235:genetics; D020033:Protein Isoforms / Q000235:genetics; D013302:Streptomyces / Q000737:chemistry / Q000166:cytology / Q000235:genetics* / Q000378:metabolism; D026801:Synteny
chemical_list: D001426:Bacterial Proteins; D020033:Protein Isoforms