title: Isobolographic analysis of interaction between vigabatrin and baclofen in the formalin test in mice.
abstract: Vigabatrin and baclofen given together, at doses not affecting motor performance, produced dose-dependent inhibition of both phases in the formalin test in mice. Isobolographic analysis revealed a significant synergy between both drugs in both phases of the forrmalin test.
authors: Second University Department of Anesthesiology and Intensive Therapy, Medical University, Lublin, Poland.
authors: M
authors: M
authors: Czuczwar
authors: J
authors: J
authors: Kiś
authors: A
authors: A
authors: Potasiński
authors: W A
authors: WA
authors: Turski
authors: K
authors: K
authors: Przesmycki
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001418:Baclofen / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D005557:Formaldehyde / Q000494:pharmacology; D018755:GABA Agonists / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D051379:Mice; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects*; D020888:Vigabatrin / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D018755:GABA Agonists; D005557:Formaldehyde; D020888:Vigabatrin; D001418:Baclofen