title: Significance of the initial arterial lactate level and transpulmonary arteriovenous lactate difference after open-heart surgery.
abstract: OBJECTIVE
  This study was conducted to determine the clinical significance of the initial lactate level and its transpulmonary difference after open-heart surgery in adult patients.
  
  
  METHODS
  The initial postoperative lactate levels were obtained from both radial and pulmonary arteries (La, Lv) in 65 consecutive patients undergoing coronary (n = 46), valve (n = 8), and aortic (n = 11) surgery. We analyzed the relationships between the perioperative factors and La and transpulmonary arteriovenous lactate difference (%La-v = 100(La - Lv)/Lv).
  
  
  RESULTS
  La and % La-v were not correlated with the preoperative factors of age, pulmonary function, or emergency surgery. La significantly correlated with the cardiopulmonary bypass time, initial arterial pH, initial PaO2/FiO2, SvO2, O2 consumption, O2 extraction rate, and the peak value of creatine phosphokinase. The %La-v significantly correlated with the aortic cross-clamp time, the lowest rectal temperature, the duration of intubation, and PaO2/FiO2 after extubation.
  
  
  CONCLUSIONS
  La may be an indicator of the invasiveness of the surgery, while %La-v may be a predictor of postoperative pulmonary function. Both La and %La-v, as an initial value in the intensive care unit, may play an important role in planning the postoperative management of patients undergoing open-heart surgery.
authors: Division of Cardiovascular Surgery, Kasugai Municipal Hospital, Kasugai, Aichi, Japan.
authors: Yoshiyuki
authors: Y
authors: Takami
authors: Hiroshi
authors: H
authors: Ina
mesh_terms: D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood*; D008168:Lung / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011184:Postoperative Period
chemical_list: D007773:Lactates