The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis.
Vg1 RBP is a member of a family of highly conserved proteins that appear to be involved in RNA localization, stability, and/or translational control in a wide variety of cell types and organisms. Over the last few years, the human homologs of these proteins have been found to be overexpressed in an increasing number of different kinds of cancers. Although the role of these proteins in neoplasia is not understood, results from several labs, including our own, are beginning to suggest that many of these proteins may be important in cell motility, a necessary requirement for metastasis. This paper will review these data and suggest a model for the role of Vg1 RBP and its homologs in embryonic development and carcinogenesis.
Yaniv
Karina
K
Department of Anatomy and Cell Biology, Hebrew University - Hadassah Medical School, POB 12272, 91121 Jerusalem, Israel.
Yisraeli
Joel K
JK
D000818:Animals; D017124:Conserved Sequence / Q000235:genetics*; D004622:Embryo, Mammalian / Q000196:embryology / Q000378:metabolism*; D004625:Embryo, Nonmammalian / Q000196:embryology / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D009369:Neoplasms / Q000235:genetics*; D010802:Phylogeny; D016601:RNA-Binding Proteins / Q000235:genetics*
C498779:IGF2BP2 protein, human; C498780:IGF2BP3 protein, human; D009363:Neoplasm Proteins; D016601:RNA-Binding Proteins