title: Usefulness as guided bone regeneration membrane of the alginate membrane.
abstract: Alginate membrane is a new bioabsorbable, guided bone regeneration (GBR) membrane, which is placed directly on the surface of the bone defect. It is designed to drop a calcium chloride aqueous solution into the bone defect, which is filled with sodium alginate aqueous solution. Alginate membrane is an excellent agent for this procedure due to its close assimilation to the surface of the bone. In this study, we evaluated the short-term biocompatibility of alginate membrane in the bone defects of rat tibiae. GBR membrane availability was also examined. Consequently, we found that the healing process in bone defects covered with an alginate membrane was delayed in comparison with that of controls, however, the defect was restored to nearly original condition. In contrast, in the controls, bone defect repairs exhibited partitioning as a result of connective tissue involvement. Furthermore, we observed a relation between the sodium alginate concentration and the rate of absorption of the sodium alginate membrane. Absorption of a 1.5% sodium alginate membrane was slow. As a result, the compound was not absorbed completely and bone repairs resembled an hourglass. Moreover, the inflammatory response was absent surrounding the alginate membrane. The present findings suggested that the alginate membrane functions effectively as a GBR membrane. In addition, the alginate membrane derived from 3% calcium chloride and 1% sodium alginate was most suitable as a GBR membrane.
authors: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Tottori University, Yonago, Japan. yoshiya@grape.med.tottori-u.ac.jp
authors: Yoshiya
authors: Y
authors: Ueyama
authors: Kunio
authors: K
authors: Ishikawa
authors: Takamitsu
authors: T
authors: Mano
authors: Takahiro
authors: T
authors: Koyama
authors: Hitoshi
authors: H
authors: Nagatsuka
authors: Kazuomi
authors: K
authors: Suzuki
authors: Kazuo
authors: K
authors: Ryoke
mesh_terms: D000042:Absorption; D000464:Alginates / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration; D018786:Bone Substitutes; D002122:Calcium Chloride / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D008297:Male; D008422:Materials Testing; D008567:Membranes, Artificial; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical; D013718:Tensile Strength; D013997:Time Factors
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D018786:Bone Substitutes; D006603:Hexuronic Acids; D008567:Membranes, Artificial; D020723:Glucuronic Acid; D002122:Calcium Chloride