[Usefulness of scintigraphy images with 111In-CYT-103 in the diagnosis of colonic and rectal recurrence].
OBJECTIVE
To determine the effectiveness of radioimmunoscintigraphy (RIC) with 111In-CYT-103 in detecting the extension of malignant disease in patients surgically treated for colorectal adenocarcinoma under suspicion of recurrence in comparison to CT scan (computed tomography) and exploratory laparotomy.


METHODS
Prospective and observational study.


METHODS
A total of 26 patients under suspicion of recurrence, with a total of 31 lesions. All the patients had performed the following studies with GT, RIC with 111In-CYT-103, exploratory laparotomy and histopathology.


RESULTS
A sensitivity of 96.8%, and specificity of 77.8%, and accuracy of 92% were found for the RIC. CT scan had a sensitivity, specificity and accuracy of 71.5%, 88.8%, and 75.7%, respectively in extrahepatic lesions. When both methods are combined, results shows an increment in sensitivity. Hepatic lesions were present in 50% of the patients; a sensitivity of 85%, a specificity of 92%, and accuracy of 89% for RIC and sensitivity, specificity and accuracy of 92% for the CT.


CONCLUSIONS
The results of clinical studies with 111In-CYT-103 in detecting the occurrence of colorectal carcinoma provided additional information, making this method a valuable complementary test that contributes to patient management.
García-Fernández
Rosalba
R
Departamento de Medicina Nuclear, Hospital de Oncología, Centro Médico Nacional Siglo XXI, IMSS, Cuauhtémoc 330, 06720 Col. Doctores, Delegación Cuauhtémoc, México D.F.
Luna-Pérez
Pedro
P
Hernández-Hernández
Dulce María
DM
Iwasaki-Otake
Laura
L
Pichardo-Romero
Pablo
P
Rodríguez-Ramirez
Saúl
S
D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000556:secondary*; D000911:Antibodies, Monoclonal; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D009842:Oligopeptides; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity
D000911:Antibodies, Monoclonal; C063430:Indium 111In-satumomab pendetide; D009842:Oligopeptides; D004369:Pentetic Acid