Solution conformation of a rationally designed nonapeptide.
Partial 'turn-helix' type modules comprised of LD and DL chiral beta-turns serving as potential helix nucleators have been connected with a view to designing a nascent 'helix-turn-helix' type structure. Conformation of the resultant peptide Boc-(D)Glu-Ala-Aib-Lys-Val-Pro-(D)Asp-Leu-Leu-NHMe has been described in both DMSO and water.
Dhanasekaran
M
M
Department of Chemistry, Biotechnology Centre, Indian Institute of Technology, Mumbai.
Srivastava
S
S
Raju
E B
EB
Durani
S
S
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008969:Molecular Sequence Data; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D014867:Water / Q000737:chemistry
D010455:Peptides; D014867:Water; D004121:Dimethyl Sulfoxide