title: Past, present and future of HIV vaccine trials in developing countries.
abstract: A safe, effective and accessible preventive vaccine is our best long-term hope for the control of the HIV/AIDS pandemic. The first phase I trial of an HIV vaccine was conducted in the US in 1987. Since then, >30 candidate vaccines have been tested in over 60 phase I/II clinical trials, involving >8000 healthy human volunteers. The majority of these trials have been conducted in the US and Europe, however, trials have also been conducted in developing countries (Brazil, China, Cuba, Haiti, Kenya, Thailand, and Uganda), including an ongoing phase III efficacy trial of a rgp120 candidate vaccine in Thailand. The effort to develop and evaluate HIV vaccines must increase, especially in Africa.
authors: WHO-UNAIDS HIV Vaccine Initiative, World Health Organisation, 1211 Geneva, Switzerland. esparzaj@who.ch
authors: José
authors: J
authors: Esparza
authors: Saladin
authors: S
authors: Osmanov
authors: Claire
authors: C
authors: Pattou-Markovic
authors: Coumba
authors: C
authors: Touré
authors: Marie Louise
authors: ML
authors: Chang
authors: Stephanie
authors: S
authors: Nixon
mesh_terms: D016915:AIDS Vaccines; D002986:Clinical Trials as Topic; D017326:Clinical Trials, Phase III as Topic; D003906:Developing Countries; D005544:Forecasting; D015658:HIV Infections / Q000517:prevention & control; D006801:Humans
chemical_list: D016915:AIDS Vaccines