3-Methylcholanthrene-inducible hepatic DNA adducts: a mechanistic hypothesis linking sequence-specific DNA adducts to sustained cytochrome P4501A1 induction by 3-methylcholanthrene.
Moorthy
Bhagavatula
B
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA. bmoorthy@bcm.tmc.edu
D000818:Animals; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism*; D018736:DNA Adducts; D004305:Dose-Response Relationship, Drug; D004587:Electrophoresis, Agar Gel; D005260:Female; D008099:Liver / Q000378:metabolism*; D008748:Methylcholanthrene / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism; D008954:Models, Biological; D010957:Plasmids / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic; D051381:Rats; D017207:Rats, Sprague-Dawley
D018736:DNA Adducts; D008748:Methylcholanthrene; D019363:Cytochrome P-450 CYP1A1