Myofibroblasts and mechano-regulation of connective tissue remodelling.
During the past 20 years, it has become generally accepted that the modulation of fibroblastic cells towards the myofibroblastic phenotype, with acquisition of specialized contractile features, is essential for connective-tissue remodelling during normal and pathological wound healing. Yet the myofibroblast still remains one of the most enigmatic of cells, not least owing to its transient appearance in association with connective-tissue injury and to the difficulties in establishing its role in the production of tissue contracture. It is clear that our understanding of the myofibroblast   its origins, functions and molecular regulation   will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.
Tomasek
James J
JJ
Department of Cell Biology, University of Oklahoma Health Sciences Center, P.O. Box 26901, Oklahoma City, OK 73190, USA. James-Tomasek@ouhsc.edu
Gabbiani
Giulio
G
Hinz
Boris
B
Chaponnier
Christine
C
Brown
Robert A
RA
D000199:Actins / Q000502:physiology; D000818:Animals; D003238:Connective Tissue / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D013314:Stress, Mechanical; D014945:Wound Healing
D000199:Actins