Results of intracytoplasmic sperm injection of single oocyte in 362 unstimulated cycles.
OBJECTIVE
The purpose was to test the adequacy of unstimulated cycles for intracytoplasmic sperm injection (ICSI) and to evaluate implantation and pregnancy rates in three different age groups.


METHODS
ICSI was performed in 362 unstimulated cycles in women up to 45 years old. All cycles were monitored by serum estradiol, urinary LH, and ultrasound.


RESULTS
The delivery rate per started cycle was higher in patients younger than 36 (9.4%) than in cycles with patient's age between 36 and 39 years (4.8%) or older than 40 (4.6%) but the difference was not statistically significant. In all groups, the fertilization rate was similar (70.4, 77.6, and 84.8%, respectively). The pregnancy rate per cycle and the pregnancy rate per puncture was similar in the group of patients in age between 36 and 39 years (8.3 and 9.7%) and those older than 40 (7.7 and 9.3%).


CONCLUSIONS
Unstimulated cycles monitored by serum estradiol, urinary LH, and ultrasound can produce an acceptable pregnancy rate after ICSI procedure only in patients younger than 36.
Vlaisavljević
Veljko
V
Department of Reproductive Medicine and Gynecologic Endocrinology, Maribor Teaching Hospital, Slovenia. vlai@sb-mb.si
Kovacic
Borut
B
Reljic
Milan
M
Lovrec
Vida Gavrić
VG
Sajko
Mojca Cizek
MC
D000328:Adult; D000367:Age Factors; D015415:Biomarkers; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D010064:Embryo Implantation; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000652:urine; D008297:Male; D006080:Ovarian Follicle / Q000000981:diagnostic imaging; D010060:Ovulation; D011247:Pregnancy; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods / Q000706:statistics & numerical data; D014463:Ultrasonography
D015415:Biomarkers; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004958:Estradiol; D007986:Luteinizing Hormone