title: Experimental mandibular regeneration by distraction osteogenesis with submerged devices: preliminary results of a canine model.
abstract: The authors describe a new technique for reconstruction of mandibular body defects. The feasibility of distraction osteogenesis with submerged (internal) devices for reconstruction of segmental mandibular defects is investigated in an experiment with five adult dogs. A segmental mandibulectomy was performed on the horizontal ramus. The bony defect was regenerated using distraction osteogenesis (bone transport) at a rate of 1 mm daily. The animals were killed after the consolidation period. Complete bone regeneration of the surgically created gap was successful in three of five dogs. Two animals failed to create new bone. In these two cases, the screws did not offer proper stability to the bony fragments, and this caused a lack of ossification. This experimental study demonstrates the possibility to use internal distraction devices to reconstruct segmental mandibular defects in a canine model. Internal devices show enormous advantages in comparison with the external ones. This method with no donor-site morbidity may become a very useful option in human mandibular reconstruction.
authors: Department of Oral and Maxillofacial Surgery, Hospital Universitario de la Princesa, Diego de León 62, 28006-Madrid, Spain. piluca10@jazzfree.com
authors: Pilar
authors: P
authors: Rubio-Bueno
authors: Fidel
authors: F
authors: Sanromán
authors: Paloma
authors: P
authors: García
authors: Mercedes
authors: M
authors: Sánchez
authors: Pilar
authors: P
authors: Llorens
authors: Santiago
authors: S
authors: Nieto
authors: Magdalena
authors: M
authors: Adrados
authors: Jesús
authors: J
authors: Sastre
authors: Fernando Ortiz
authors: FO
authors: de Artiñano
authors: Samuel
authors: S
authors: Amde
authors: Luis
authors: L
authors: Naval
authors: Francisco J
authors: FJ
authors: Díaz-González
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D004285:Dogs; D016268:Internal Fixators; D008334:Mandible / Q000601:surgery*; D023421:Models, Animal; D019857:Osteogenesis, Distraction / Q000295:instrumentation*