title: Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda.
abstract: The effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression was investigated in 1045 adults in Uganda. At enrollment and every 6 months, a clinical history, examination, and laboratory investigations that included CD4 cell counts were done. HIV-1 envelope subtype was assessed mainly by peptide serology supplemented by heteroduplex mobility assay and DNA sequencing. A multivariate analysis of survival was performed to assess the prognostic value of HIV-1 subtype on death. A marginal general linear model also determined the effect of subtype on CD4 cell count during follow-up. Subtype D was associated with faster progression to death (relative risk, 1.29; 95% confidence interval, 1.07-1.56; P=.009) and with a lower CD4 cell count during follow-up (P=.001), compared with subtype A, after adjusting for CD4 cell count at enrollment. In Africa, envelope subtype D is associated with faster disease progression, compared with subtype A.
authors: Medical Research Council Programme on AIDS, Uganda Virus Research Institute, Entebbe, Uganda. mrc@starcom.co.ug
authors: Pontiano
authors: P
authors: Kaleebu
authors: Neil
authors: N
authors: French
authors: Cedric
authors: C
authors: Mahe
authors: David
authors: D
authors: Yirrell
authors: Christine
authors: C
authors: Watera
authors: Fred
authors: F
authors: Lyagoba
authors: Jessica
authors: J
authors: Nakiyingi
authors: Alleluiah
authors: A
authors: Rutebemberwa
authors: Dilys
authors: D
authors: Morgan
authors: Jonathan
authors: J
authors: Weber
authors: Charles
authors: C
authors: Gilks
authors: Jimmy
authors: J
authors: Whitworth
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000401:mortality / Q000821:virology*; D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D015497:HIV-1 / Q000145:classification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014454:Uganda