title: Carbon monoxide and human disease.
abstract: Carbon monoxide is produced endogenously in humans through the breakdown of hemoglobin by heme oxygenase. Although originally thought to be a superfluous by-product of heme catabolism, carbon monoxide is now known to play a central role in many aspects of human health and disease. The functions of carbon monoxide that have been described to date are myriad, including blood pressure regulation, maintenance of organ-specific vascular tone, neurotransmission, stress response, platelet activation, and smooth muscle relaxation. This review outlines what is known to date about carbon monoxide as it relates to human disease.
authors: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, MUH 628NW, 3459 Fifth Ave, Pittsburgh, PA 15213, USA.
authors: Danielle
authors: D
authors: Morse
authors: Jigme
authors: J
authors: Sethi
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000502:physiology*; D002319:Cardiovascular System; D005260:Female; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D051547:Heme Oxygenase-1; D006801:Humans; D008297:Male; D008565:Membrane Proteins; D011247:Pregnancy; D012098:Reproduction / Q000502:physiology
chemical_list: D008565:Membrane Proteins; D002248:Carbon Monoxide; C496541:HMOX1 protein, human; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1