[Cloning and analysis of human alpha-1B glycoprotein precursor gene: a novel member of human immunoglobulin superfamily].
A cDNA of 1694 bp was cloned from human liver Marathon cDNA by means of Rapid Amplification of cDNA Ends (RACE). The cDNA has an open reading frame at 43-1530 bp encoding 495 amino acid residues and a 17-residue signal peptide. There are four Igc2 domains in the translated polypeptide, which is highly homologous to the human alpha-1B glycoprotein isolated from human plasma. Upon this, we conclude that this cDNA is the alpha-1B glycoprotein precursor gene which has never been cloned before, and it may be a novel member of immunoglobulin superfamily and may involved in the cell recognition and the regulation of cell behavior.
Sun
Di
D
Department of Medical Genetics, China Medical University, Shenyang 110001, China.
Zhao
Yan-Yan
YY
Dai
Shu-Ping
SP
Fang
Kai
K
Dong
Ling-Yue
LY
Ding
Qian
Q
D001798:Blood Proteins / Q000235:genetics* / Q000502:physiology; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry; D006023:Glycoproteins; D006801:Humans; D007136:Immunoglobulins; D011498:Protein Precursors / Q000235:genetics*
C048566:A1BG protein, human; D001798:Blood Proteins; D018076:DNA, Complementary; D006023:Glycoproteins; D007136:Immunoglobulins; D011498:Protein Precursors