title: Wingful, an extracellular feedback inhibitor of Wingless.
abstract: Secreted peptide signals control many fundamental processes during animal development. Proper responses to these signals require cognate inducible feedback antagonists. Here we report the identification of a novel Drosophila Wingless (Wg) target gene, wingful (wf), and show that it encodes a potent extracellular feedback inhibitor of Wg. In contrast to the cytoplasmic protein Naked cuticle (Nkd), the only known Wg feedback antagonist, Wf functions during larval stages, when Nkd function is dispensable. We propose that Wf may provide feedback control for the long-range morphogen activities of Wg.
authors: Institut für Molekularbiologie, Universität Zürich, CH-8057 Zürich, Switzerland.
authors: Offer
authors: O
authors: Gerlitz
authors: Konrad
authors: K
authors: Basler
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004950:Esterases / Q000235:genetics / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D025461:Feedback, Physiological; D018507:Gene Expression Regulation, Developmental; D019476:Insect Proteins / Q000378:metabolism; D007814:Larva; D008969:Molecular Sequence Data; D009154:Mutation; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D051155:Wnt1 Protein
chemical_list: D029721:Drosophila Proteins; D019476:Insect Proteins; C456459:Notum protein, Drosophila; D011518:Proto-Oncogene Proteins; D051155:Wnt1 Protein; C405336:nkd protein, Drosophila; C074622:wg protein, Drosophila; D004950:Esterases; C100533:pectinacetylesterase