The mechanism and regulation of chromosomal V(D)J recombination.
V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.
Bassing
Craig H
CH
Howard Hughes Medical Institute, The Children's Hospital, The Center for Blood Research, Boston, MA 02115, USA.
Swat
Wojciech
W
Alt
Frederick W
FW
D000818:Animals; D002454:Cell Differentiation; D002875:Chromosomes / Q000235:genetics*; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D015321:Gene Rearrangement / Q000235:genetics*; D005803:Genes, Immunoglobulin / Q000235:genetics*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D009687:Nuclear Proteins; D011995:Recombination, Genetic / Q000235:genetics*; D045567:VDJ Recombinases
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; C499311:RAG2 protein, human; C064655:V(D)J recombination activating protein 2; C064658:RAG-1 protein; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases