[Changes in spontaneous blast transformation of children's lymphocytes which have been observed in vitro in the last years].
In the Immunology Department of the Institute of Mother and Child in Warsaw we have used lymphocyte blastic transformation test (LETT) over 30 years to study lymphocyte function. During the last 10 years we have noticed progressive elevation of lymphocyte percentage undergoing spontaneous blast transformation (autotransformation) in culture of these cells. The percentage rose from mean value of 2.5% to 14.7% in year 2000 with statistically significant difference already between 1985 and 1990 (2.5% versus 9.3%). The reason for this phenomenon is unknown and needs more investigations.
Derentowicz
P
P
Zaklad Immunologii, Instytut Matki i Dziecka, Kasprzaka 17a, 01-211 Warszawa, Poland. immunolog@imid.med.pl
Wawrzyniak
M
M
Markiewicz
K
K
Czerwinska
I
I
Siwinska-Golebiowska
H
H
D002478:Cells, Cultured; D002648:Child; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D011044:Poland; D012189:Retrospective Studies; D013997:Time Factors