Immunity to Onchocerca spp. in animal hosts.
This review summarizes research using Onchocerca spp. in chimpanzees, cattle and mice to gain insight into the protective immune response to the filarial worm Onchocerca volvulus in humans. In addition, Acanthocheilonema viteae has been evaluated as a surrogate filarial worm for studying immunity to the infection. Immune mechanisms controlling these infections are described and initial success using recombinant antigen vaccines in these models is reviewed.
Abraham
David
D
Dept of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA. david.abraham@mail.tju.edu
Lucius
Richard
R
Trees
Alexander J
AJ
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth / Q000032:analysis / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D005849:Gerbillinae; D006801:Humans; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D009854:Onchocerca / Q000276:immunology*; D017181:Onchocerca volvulus / Q000276:immunology; D009855:Onchocerciasis / Q000517:prevention & control*; D002679:Pan troglodytes; D013997:Time Factors
D000909:Antibodies, Helminth; D000947:Antigens, Helminth