[1,25-dihydroxyvitamin D3: the endocrine system meets the immune system].
1,25(OH)2D3, the activated form of vitamin D, is well known for its effects on calcium and bone metabolism, but also non-classical effects on cells of the immune system were described, in vivo as well as in vitro. Structural analogues have been developed with less calcemic effects, but at least comparable immune effects. Our group showed that treatment with 1,25(OH)2D3 can protect the NOD mouse, the murine model for type 1 diabetes, from diabetes in primary, secondary and tertiary prevention. This effect is based on shifts in cytokine profiles (Thelper1 to Thelper2), that occur specifically for the autoantigens, and on enhanced sensitivity of the autoreactive T lymphocytes to apoptotic signals thus leading to a better elimination of these potentially dangerous cells. 1,25(OH)2D3 and its analogues can therefore be considered as interventions aimed at the prevention or treatment of human type 1 diabetes.
Mathieu
C
C
Laboratorium voor Experimentele Geneeskunde en Endocrinologie (LEGENDO), Onderwijs en Navorsing, Gasthuisberg, Herestraat 49, B-3000 Leuven.
Decallonne
B
B
van Etten
E
E
D000818:Animals; D002117:Calcitriol / Q000276:immunology* / Q000494:pharmacology / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004703:Endocrine System / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000502:physiology*; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D051379:Mice; D016688:Mice, Inbred NOD
D002117:Calcitriol