Predictors of nursing home admission and/or death in incident Alzheimer's disease and other dementia cases compared to controls: a population-based study.
This research elucidates the risk of institutional care and/or death of patients with Alzheimer's disease (AD) or other dementia (OD) compared with noncases. Community dwelling incident cases of AD (n = 240) or OD (n = 208) and age-matched noncases (n = 363) living in an enumerated population were included. The adjusted hazard ratio (HR) of being admitted to a nursing home compared with controls was 5.44 (95% confidence interval, CI: 3.68,8.05) for AD cases and 5.08 (95% CI: 3.38, 7.63) for OD cases. The adjusted RR of death compared to controls was 1.90 (95% CI: 1.36, 2.65) for AD cases and 2.27 (95% CI: 1.62, 3.18) for OD cases. This is the only population-based study in the U.S. documenting that AD/OD increases the risk of death independent of comorbid conditions. AD/OD patients have more comorbidities and are at greater risk of entering a nursing home than to die during the follow-up, compared with those without these diagnoses.
Eaker
Elaine D
ED
Eaker Epidemiology Enterprises, LLC, 8975 Country Road V, Chili, WI 54420, USA. eakerepi@tznet.com
Vierkant
Robert A
RA
Mickel
Susan F
SF
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000401:mortality* / Q000628:therapy; D016022:Case-Control Studies; D015897:Comorbidity; D003704:Dementia / Q000401:mortality / Q000628:therapy; D005260:Female; D015577:Geriatric Assessment; D006707:Homes for the Aged / Q000706:statistics & numerical data*; D006801:Humans; D007326:Institutionalization / Q000706:statistics & numerical data*; D008297:Male; D009735:Nursing Homes / Q000706:statistics & numerical data*; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D014922:Wisconsin / Q000453:epidemiology