Analysis of exhaled breath condensate for monitoring airway inflammation.
Several inflammatory mediators have been identified in the exhaled breath condensate (EBC) that is formed by breathing through a cooling system. Analysis of EBC is a noninvasive method that allows repeat measurements of lung inflammation and is potentially useful for monitoring drug therapy. Characterization of the profiles of exhaled markers could help to discriminate between different inflammatory lung diseases; thus, EBC might be a novel, noninvasive approach to monitoring lung diseases. However, several methodological issues, such as standardization of sample collection and validation of analytical techniques, need to be addressed before this method can be applied clinically. Controlled studies are needed to establish the utility of EBC markers for guiding pharmacological treatment in inflammatory lung diseases.
Montuschi
Paolo
P
Dept of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, 00168 Rome, Italy. p.montuschi@ic.ac.uk
Barnes
Peter J
PJ
D001944:Breath Tests / Q000379:methods*; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis; D007249:Inflammation / Q000175:diagnosis*; D018836:Inflammation Mediators / Q000032:analysis*; D028421:Isoprostanes / Q000032:analysis; D008171:Lung Diseases / Q000175:diagnosis*; D009569:Nitric Oxide / Q000032:analysis; D018384:Oxidative Stress; D011453:Prostaglandins / Q000032:analysis
D018836:Inflammation Mediators; D028421:Isoprostanes; D011453:Prostaglandins; D009569:Nitric Oxide; D006861:Hydrogen Peroxide