Molecular mechanisms of cancer pain.
Pain is the most disruptive influence on the quality of life of cancer patients. Although significant advances are being made in cancer treatment and diagnosis, the basic neurobiology of cancer pain is poorly understood. New insights into these mechanisms are now arising from animal models, and have the potential to fundamentally change the way that cancer pain is controlled.
Mantyh
Patrick W
PW
Department of Preventive Sciences, University of Minnesota, Minneapolis 55455, USA. manty001@tc.umn.edu
Clohisy
Denis R
DR
Koltzenburg
Martin
M
Hunt
Steve P
SP
D000344:Afferent Pathways / Q000503:physiopathology*; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D009475:Neurons, Afferent / Q000502:physiology; D009619:Nociceptors / Q000502:physiology; D010146:Pain