title: Spermine alkaloids from Albizia adinocephala with activity against Plasmodium falciparum plasmepsin II.
abstract: Crude MeOH extracts from the stem bark and leaves of a Panamanian specimen of Albizia adinocephala (Leguminosae) were found to inhibit the malarial enzyme plasmepsin II. Bioassay guided fractionation led to the isolation of two new bioactive spermine alkaloids, budmunchiamines L4 and L5.
authors: Centre for Natural Product Research, 59A Science Park Drive, The Fleming, Singapore Science Park, 118240, Singapore.
authors: Simon P B
authors: SP
authors: Ovenden
authors: Shugeng
authors: S
authors: Cao
authors: Chungyan
authors: C
authors: Leong
authors: Horst
authors: H
authors: Flotow
authors: Mahabir P
authors: MP
authors: Gupta
authors: Antony D
authors: AD
authors: Buss
authors: Mark S
authors: MS
authors: Butler
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D016282:Aspartic Acid Endopeptidases / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D007887:Fabaceae / Q000737:chemistry*; D015394:Molecular Structure; D018514:Plant Structures / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000201:enzymology*; D015800:Protozoan Proteins; D013055:Spectrophotometry, Infrared; D013096:Spermine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D015800:Protozoan Proteins; D013096:Spermine; D016282:Aspartic Acid Endopeptidases; C100637:plasmepsin II