title: Effects of molybdenum, silicon and nickel on alpha1-adrenoceptor-induced constriction of rat isolated aorta.
abstract: 1. To determine the effects of trace elements on alpha1-adrenoceptor-mediated vasoconstriction, we studied the effects of molybdenum (Mo), silicon (Si) and nickel (Ni) on vasoconstrictor response to an alpha1-adrenoceptor agonist in rat aorta. 2. Cumulative concentration-contraction curves were obtained for phenylephrine (1 nmol/L-10 micromol/L) in the absence and presence of Mo, Si and Ni (0.3, 1 and 3 micromol/L) in rat aorta rings. Increasing the concentration of Mo and Si from 0.3 to 3 micromol/L shifted the cumulative concentration-contraction curve to the right, but did not reduce the maximal contractile response to phenylephrine. In contrast, Ni at 1 and 3 micromol/L shifted the cumulative concentration-contraction curve to the right and, at 3 micromol/L, reduced the maximum contractile response to phenylephrine. 3. We conclude that micromolar concentrations of Mo, Si and Ni affected alpha1-adrenoceptor-induced vasoconstriction and that Ni significantly inhibited the maximal contractile response to phenylephrine in rat isolated aorta.
authors: Cardiac Research Laboratory, National Heart Centre of Singapore, Singapore.
authors: Dong Ling
authors: DL
authors: Liu
authors: Ming
authors: M
authors: Yan
authors: Yeow Leng
authors: YL
authors: Chua
authors: Chen
authors: C
authors: Chen
authors: Yean Leng
authors: YL
authors: Lim
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008982:Molybdenum / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D009532:Nickel / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects*; D012825:Silicon / Q000494:pharmacology*
chemical_list: D018340:Receptors, Adrenergic, alpha-1; D009532:Nickel; D008982:Molybdenum; D012825:Silicon