title: Synthesis, antiviral and cytostatic activities, of carbocyclic nucleosides incorporating a modified cyclopentane ring. IV. Adenosine and uridine analogues.
abstract: Eight new carbocyclic nucleosides were prepared by mounting a purine (compounds 8-10), 8-azapurine (12 and 13) or pyrimidine (15, 16 and 17b) on the amino group of (1S,3R)-3-aminomethyl-2,2,3-trimethylcyclopentylmethanol (6). All the compounds were evaluated as antiviral and antitumor agents in a variety of assay systems. Only compound 8 showed any cytostatic activity against the tumor cell lines examined.
authors: Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago, Santiago de Compostela, Spain.
authors: M Isabel
authors: MI
authors: Nieto
authors: Olga
authors: O
authors: Caamaño
authors: Franco
authors: F
authors: Fernández
authors: Maria
authors: M
authors: Gómez
authors: Jan
authors: J
authors: Balzarini
authors: Erik
authors: E
authors: De Clercq
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D013329:Structure-Activity Relationship; D014529:Uridine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014709:Vero Cells
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D003517:Cyclopentanes; D000241:Adenosine; D014529:Uridine