Inositol phosphates: a remarkably versatile enzyme.
Ins(3,4,5,6)P(4) is an inhibitor of Ca(2+)-activated Cl(-) channels, but further understanding has been hindered by ignorance of how it is made in cells. It now transpires that one protein with ATP-dependent kinase and phosphatase activities interconverts Ins(3,4,5,6)P(4) and Ins(1,3,4,5,6)P(5), as well as several other inositol polyphosphates.
Michell
Robert H
RH
School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK. r.h.michell@bham.ac.uk
D004847:Epithelial Cells / Q000378:metabolism; D007295:Inositol Phosphates / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D015398:Signal Transduction
D007295:Inositol Phosphates; D017853:Phosphotransferases (Alcohol Group Acceptor); D010744:Phosphoric Monoester Hydrolases