Postprandial elevation of remnant lipoprotein leads to endothelial dysfunction.
Recent studies have demonstrated that elevated levels of cholesterol in the form of remnant-like particles (RLP-C) induce deterioration of endothelial function during the fasting state, but it is not known whether postprandial RLP-C elevation has the same effect. The objective of this study was to assess the effect of postprandial RLP-C elevation on endothelial function in 24 fasting normolipidemic subjects. Flow-mediated dilatation (FMD) during reactive hyperemia in the brachial artery was investigated. Serum lipids and lipoproteins during fasting and 4h after regular fat-loading were measured. Subjects were divided into 2 groups: the high responders (postprandial RLP-C level >7.5mg/dl, n=8) and the normal responders (postprandial RLP-C level < or =7.5mg/dl, n=16). Significant increases in the level of both triglycerides and RLP-C were observed in the high responders. Basal FMD in the high responders (4.3+/-3.0%) was significantly lower than that in the normal responders (8.3+/-2.4%) (p<0.01), but FMD after the fat-loading in both groups did not change significantly. The change in RLP-C levels during the fat-loading test correlated significantly with basal FMD (r=-0.588, p<0.01). Multiple regression analysis showed a significant correlation between basal FMD and the change in RLP-C levels (r=-0.488, p<0.02). The results of this study suggest that postprandial RLP-C elevation could be associated with atherosclerotic progression even in normolipidemic subjects.
Funada
Jun-ichi
J
Department of Cardiology, Ehime National Hospital, Ehime University School of Medicine, Japan. jfunada@ehime-nh.go.jp
Sekiya
Michihito
M
Hamada
Mareomi
M
Hiwada
Kunio
K
D000293:Adolescent; D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005215:Fasting; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D019518:Postprandial Period; D012016:Reference Values; D014280:Triglycerides / Q000097:blood*
D001053:Apolipoproteins; D015415:Biomarkers; D008076:Cholesterol, HDL; D008074:Lipoproteins; D010446:Peptide Fragments; D014280:Triglycerides; C112017:remnant-like particle cholesterol; D002784:Cholesterol