Intrauterine growth restriction (IUGR): biometric and Doppler assessment.
Intrauterine growth restriction (IUGR) is a common complication in pregnancy and influences morbidity and mortality at all stages of life. Historically, the management of IUGR has been dependent on antenatal biophysical testing and umbilical artery Doppler studies. With recent Doppler studies of the fetal central circulation, including intracardiac flows and the ductus venosus, better timing of delivery to minimize morbidity may be possible. This review will provide the reader with tools to diagnose IUGR, more accurately date the IUGR pregnancy with poor dating criteria, and better assess the condition of the IUGR fetus. A brief review of animal models of IUGR is presented to demonstrate research directions for answering human clinical questions and potentially carrying therapeutic intervention from the bench to the bedside.
Galan
Henry L
HL
Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver 80262, USA. Henry.Galan@UCHSC.edu
Ferrazzi
Enrico
E
Hobbins
John C
JC
D000818:Animals; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods / Q000592:standards; D023421:Models, Animal; D011247:Pregnancy; D011256:Pregnancy Outcome; D011673:Pulsatile Flow; D016216:Ultrasonography, Prenatal / Q000379:methods / Q000592:standards