title: Shape differences in the corpus callosum in first-episode schizophrenia and first-episode psychotic affective disorder.
abstract: OBJECTIVE
  The corpus callosum, the largest white matter tract in the brain, is a midline structure associated with the formation of the hippocampus, septum pellucidum, and cingulate cortex, which have been implicated in the pathogenesis of schizophrenia. Corpus callosum shape deformation, therefore, may reflect a midline neurodevelopmental abnormality.
  
  
  METHODS
  Corpus callosum area and shape were analyzed in 14 first-episode psychotic patients with schizophrenia, 19 first-episode psychotic patients with affective disorder, and 18 normal comparison subjects.
  
  
  RESULTS
  No statistically significant corpus callosum area differences between groups were found, but there were differences in the structure's shape between the patients with schizophrenia and the comparison subjects. A correlation between width and angle of the corpus callosum was found in patients with affective disorder.
  
  
  CONCLUSIONS
  Corpus callosum shape abnormalities in first-episode psychotic patients with schizophrenia may reflect a midline neurodevelopmental abnormality.
authors: Consolidated Department of Psychiatry, Harvard Medical School and VA Boston Healthcare System-Brockton Division, 02301, USA.
authors: Melissa
authors: M
authors: Frumin
authors: Polina
authors: P
authors: Golland
authors: Ron
authors: R
authors: Kikinis
authors: Yoshio
authors: Y
authors: Hirayasu
authors: Dean F
authors: DF
authors: Salisbury
authors: John
authors: J
authors: Hennen
authors: Chandlee C
authors: CC
authors: Dickey
authors: Mark
authors: M
authors: Anderson
authors: Ferenc A
authors: FA
authors: Jolesz
authors: W Eric L
authors: WE
authors: Grimson
authors: Robert W
authors: RW
authors: McCarley
authors: Martha E
authors: ME
authors: Shenton
mesh_terms: D000328:Adult; D000341:Affective Disorders, Psychotic / Q000175:diagnosis*; D001185:Artificial Intelligence; D003337:Corpus Callosum / Q000033:anatomy & histology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000706:statistics & numerical data; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis*