title: Interactions of intercellular adhesion molecule-1 with fibrinogen.
abstract: The binding of plasma protein fibrinogen (Fg) to intercellular adhesion molecule-1 (ICAM-1) on endothelial cells mediates the attachment of leukocytes and platelets that may result in vascular occlusion. Fg:ICAM-1 interactions elicit an array of effects that could have implications in vascular pathology and inflammation. ICAM-1 expression is regulated during inflammation and upon Fg binding. The mechanistic model presented provides a framework to delineate the consequences of Fg binding to ICAM-1.
authors: Department of Physiology & Biophysics, University of Louisville, Louisville, KY 40292, USA.
authors: Nina L
authors: NL
authors: Tsakadze
authors: Zhendong
authors: Z
authors: Zhao
authors: Stanley E
authors: SE
authors: D'Souza
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D005340:Fibrinogen / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D010766:Phosphorylation; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D018799:Intercellular Adhesion Molecule-1; D005340:Fibrinogen