Microbial transformation of danazol.
Danazol (17beta-hydroxy-17alpha-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium lini, Aspergillus niger, and Cephalosporium aphidicola yielded 17beta-hydroxy-2-(hydroxymethyl)-17-alpha-pregn-4-en-20-yn-3-one (2) and 17beta-hydroxy-2-(hydroxymethyl)-17 alpha-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with Bacillus cerus yielded compound 2 only.
Choudhary
M Iqbal
MI
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan.
Azizuddin
Atta-ur-Rahman
D000164:Acremonium / Q000378:metabolism; D001234:Aspergillus niger / Q000378:metabolism; D001409:Bacillus cereus / Q000378:metabolism; D001711:Biotransformation; D003613:Danazol / Q000031:analogs & derivatives / Q000737:chemistry* / Q000302:isolation & purification*; D005285:Fermentation; D005670:Fusarium / Q000378:metabolism; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
C470070:17-hydroxy-2-(hydroxymethyl)-17-pregn-4-en-20-yn-3-one; C470071:17-hydroxy-2-(hydroxymethyl)-17-pregna-1,4-dien-20-yn-3-one; D003613:Danazol