Kell expression on myeloid progenitor cells.
Kell is one of the major human red blood cell groups and comprises 22 antigens. These antigens are produced by alleles located on chromosome 7, including sets of antithetical antigens such as Kell (K, K1) and cellano (k, K2), which differ in a single amino acid change (T193M). It consists of a 93-Kd transmembrane glycoprotein that is surface-exposed and shares sequence and structural homology with zinc endopeptidases, which are involved in regulating bioactive peptides. Anti-Kell antibodies have been shown to suppress fetal erythropoiesis. Recently published data indicate a similar effect on myeolopoiesis and megakaryopoiesis. Substantial thrombocytopenia in fetuses affected with HDN due to anti-K antibodies led to the discovery of the inhibitory effect of Kell-related antibodies on CFU-MK growth. In addition to its inhibitory effect on BFU-E growth, anti-Kell antibodies significantly reduced CFU-GM colony formation from haematologically normal individuals. Moreover, anti-cellano and anti-Kp(b) antibodies also inhibited the growth of CFU-GM from antigen positive MNC. These data indicate that Kell is not restricted to erythroid blood cells, but is expressed on a broader spectrum of haematopoietic cells than previously believed.
Wagner
T
T
Department of Blood Group Serology and Transfusion Medicine, University Hospital Graz, Austria. thomas.wagner@kfunigraz.ac.at
Lanzer
G
G
Geissler
K
K
D001323:Autoantibodies / Q000009:adverse effects / Q000097:blood; D006410:Hematopoiesis / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D007518:Isoantibodies / Q000009:adverse effects / Q000097:blood; D007626:Kell Blood-Group System / Q000276:immunology* / Q000378:metabolism; D023461:Myeloid Progenitor Cells / Q000276:immunology*
D001323:Autoantibodies; D007518:Isoantibodies; D007626:Kell Blood-Group System