[Detection of anti-HAV, anti-HBV, anti-HCV and anti-HEV antibodies in the patients with sporadic acute hepatitis in Beijing during 1995-2000].
BACKGROUND
To investigate distribution of acute hepatitis A, hepatitis B, hepatitis C and hepatitis E in Beijing area.


METHODS
Enzyme immunoassay (EIA) was used for detection of anti-HAV immunoglobulin M (IgM), HBsAg/anti-HBc IgM, anti HCV IgM/IgG and anti-HEV IgM/IgG. The samples were collected from the patients with sporadic hepatitis in Beijing city between 1995 and 2000.


RESULTS
The total positive rate of IgM antibodies to the four hepatitis-viruses was 72.4% (155) among 214 patients with sporadic acute hepatitis; the positive rates for the 4 viruses were 29% (45) for anti-HAV, 18.1% (28) for anti-HBc, 3.9% (6) for anti-HCV and 49% (76) for anti-HEV among 155 patients with acute viral hepatitis. Nine patients were coinfected with two hepatitis viruses.


CONCLUSIONS
78% of patients with sporadic acute hepatitis were caused by enterically transmitted hepatitis viruses (A and E) in Beijing between 1995 and 2000, Hepatitis E had the highest rate. Coinfection with two hepatitis virus was found in the patient with intravenous drug abusers and cirrhosis or acute hepatitis.
Jiang
Y
Y
Institute of Virology, Chinese Academy Preventive Medicine, Beijing 100052, China.
Lu
J
J
Zhao
H
H
D000208:Acute Disease; D000328:Adult; D002681:China / Q000453:epidemiology; D035922:Hepatitis A Antibodies / Q000097:blood; D006508:Hepatitis Antibodies / Q000097:blood*; D006510:Hepatitis B Antibodies / Q000097:blood; D018937:Hepatitis C Antibodies / Q000097:blood; D016751:Hepatitis E / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008875:Middle Aged
D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies; D006510:Hepatitis B Antibodies; D018937:Hepatitis C Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M