[Synthetic peptides -- analogs of biologically active fragment of the differentiation factor from HL-60 cells show radioprotective and adaptogenic activities].
It was shown that the addition of synthetic six-membered peptide (HLDF-6) and its Tyr-analog (HLDF-Y) to cultural medium significantly increased the survival of cells HL-60, treated by cold shock. The prophylactic administration of HDLF-Y (1 mg/kg, 4 hours prior to applied actions) decreased the response of hypothalamushypophysis-adrenal glands system and sympathicoadrenal system of rat males on supercooling and also increased the resistance of mouse males to supercooling and X-irradiation. In the experiences with females HDLF-Y did not show the similar biological activity.
Goncharenko
E N
EN
Lomonosov Moskow State University, 119899 Russia.
Deev
L I
LI
Kostanian
I A
IA
Astapova
M V
MV
Akhalaia
M Ia
MIa
Kudriashova
N Iu
NIu
Surina
E A
EA
D000222:Adaptation, Physiological; D000305:Adrenal Cortex Hormones / Q000032:analysis*; D000311:Adrenal Glands / Q000737:chemistry; D000818:Animals; D017209:Apoptosis; D015306:Biogenic Monoamines / Q000032:analysis*; D002454:Cell Differentiation; D002470:Cell Survival; D003080:Cold Temperature; D003470:Culture Media; D003627:Data Interpretation, Statistical; D004285:Dogs; D004837:Epinephrine / Q000032:analysis; D005260:Female; D005470:Fluorometry; D018922:HL-60 Cells / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009363:Neoplasm Proteins; D009638:Norepinephrine / Q000032:analysis; D010446:Peptide Fragments / Q000494:pharmacology*; D011829:Radiation Dosage; D011836:Radiation Tolerance; D011839:Radiation, Ionizing; D011837:Radiation-Protective Agents; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000032:analysis; D012737:Sex Factors; D013154:Spleen / Q000737:chemistry; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D015306:Biogenic Monoamines; D003470:Culture Media; D009363:Neoplasm Proteins; D010446:Peptide Fragments; D011837:Radiation-Protective Agents; C091149:cell differentiation factor 8.2-kDa; D012701:Serotonin; D009638:Norepinephrine; D004837:Epinephrine