Basic fibroblast growth factor infusion increases tumour vascularity, blood flow and chemotherapy uptake.
Tumour response depends on intratumoural cytotoxic concentration, which varies with tumour vascularity. We determined whether basic fibroblast growth factor (bFGF) infusion increased tumour vascularity, blood flow and cytotoxic drug uptake. The effect of interstitial and systemic bFGF infusion was compared with that of saline-infused controls using animal HSN and K12/TR tumour models. Changes in tumour vascularity were assessed by immunohistochemical staining of tumour sections. Blood flow and drug uptake were studied using a radiotracer method. There were significant increases in tumour vascularity, vessel length density and blood flow with both interstitial and systemic bFGF infusions, and a significant increase in tumour fluorouracil uptake after systemic bFGF infusion of liver tumours. The effects were independent of tumour type, and could be produced by bFGF administration after initial tumour growth. bFGF infusion increased tumour fluorouracil uptake. Further studies are required to determine the risks and benefits with this approach to increasing tumour cytotoxic uptake.
Davies
Michael M
MM
Department of Surgery, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, UK.
Burke
Dermot
D
Carnochan
Paul
P
Glover
Clare
C
Kaur
Suki
S
Allen-Mersh
Timothy G
TG
D000230:Adenocarcinoma / Q000098:blood supply* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000493:pharmacokinetics*; D001783:Blood Flow Velocity / Q000187:drug effects; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage*; D005354:Fibrosarcoma / Q000098:blood supply* / Q000378:metabolism / Q000503:physiopathology; D005472:Fluorouracil / Q000493:pharmacokinetics*; D007262:Infusions, Intravenous; D008114:Liver Neoplasms, Experimental / Q000098:blood supply* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012878:Skin Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000503:physiopathology
D000964:Antimetabolites, Antineoplastic; D016222:Fibroblast Growth Factor 2; D005472:Fluorouracil