title: Unique genetic variation revealed by a microsatellite polymorphism survey in ten wild-derived inbred strains.
abstract: Here we report on a genome polymorphism survey using 254 microsatellite markers in ten recently wild-derived inbred strains. Allele size analysis showed that the rate of polymorphism of these wild-derived mouse strains when compared with any of the common laboratory strains is on average 79.8%. We found 632 wild-derived alleles that were not present in the common laboratory strains, representing a 61% increase over the genetic variation observed in the laboratory strains. We also found that on average 14.5% of the microsatellite alleles of any given wild-derived inbred strain were unique. Our results indicate that the recently wild-derived mouse strains represent repositories of unique naturally occurring genetic variability and may prove invaluable for the study of complex phenotypes and in the construction of new mouse models of human disease.
authors: Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6, Oeiras, Portugal.
authors: Susana
authors: S
authors: Campino
authors: Catja
authors: C
authors: Behrschmidt
authors: Sébastien
authors: S
authors: Bagot
authors: Jean-Louis
authors: JL
authors: Guénet
authors: Pierre-André
authors: PA
authors: Cazenave
authors: Dan
authors: D
authors: Holmberg
authors: Carlos
authors: C
authors: Penha-Gonçalves
mesh_terms: D000483:Alleles; D000818:Animals; D005787:Gene Frequency; D014644:Genetic Variation; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D018895:Microsatellite Repeats / Q000235:genetics*; D009115:Muridae; D011110:Polymorphism, Genetic