title: Early psychomotor slowing predicts the development of HIV dementia and autopsy-verified HIV encephalitis.
abstract: OBJECTIVES- To ask if slowed motor speed predicts later human immunodeficiency virus (HIV) dementia and HIV encephalitis. METHODS- In 100 deceased acquired immunodeficiency syndrome (AIDS) patients prior results from repeated testing of the movement reaction time test were correlated with later clinical signs of HIV dementia and with neuropathological signs of HIV encephalitis. Autopsy was performed in 72 patients. RESULTS- Movement reaction time 1-2 years prior to death, or at the time of clinical AIDS diagnosis predicted both development of HIV dementia (P<0.05) and HIV encephalitis at autopsy (P<0.01). CONCLUSION- Testing for early psychomotor slowing may be used to identify patients at risk of HIV dementia and HIV encephalitis.
authors: Department of Infectious Diseases Ullevål University Hospital, Oslo, Norway. oona.dunlop@ulleval.now
authors: O
authors: O
authors: Dunlop
authors: R
authors: R
authors: Bjørklund
authors: J N
authors: JN
authors: Bruun
authors: R
authors: R
authors: Evensen
authors: A K
authors: AK
authors: Goplen
authors: K
authors: K
authors: Liestøl
authors: M
authors: M
authors: Sannes
authors: J
authors: J
authors: Maehlen
authors: B
authors: B
authors: Myrvang
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000503:physiopathology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001344:Autopsy; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011596:Psychomotor Disorders / Q000821:virology*; D011930:Reaction Time