title: Synthesis of alkaloid 223A and a structural revision.
abstract: [structure: see text] Synthesis of alkaloid 223A has been achieved by sequential use of our original conjugate addition reaction to enaminoesters as the key step. The proposed structure for natural 223A (A, absolute configuration unknown) was revised to B, and the relative stereostructure was determined to be 5R*,6R*,8R*,9S* by the present synthesis.
authors: Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, 930-0194, Japan. toyooka@ms.toyama-mpu.ac.jp
authors: Naoki
authors: N
authors: Toyooka
authors: Ayako
authors: A
authors: Fukutome
authors: Hideo
authors: H
authors: Nemoto
authors: John W
authors: JW
authors: Daly
authors: Thomas F
authors: TF
authors: Spande
authors: H Martin
authors: HM
authors: Garraffo
authors: Tetsuo
authors: T
authors: Kaneko
mesh_terms: D000818:Animals; D001001:Anura / Q000378:metabolism*; D007202:Indicators and Reagents; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism
chemical_list: C104548:6,8-diethyl-5-propylindolizidine; D007202:Indicators and Reagents; D007212:Indolizines