Constituents of Burasaïa madagascarensis: a new clerodane-type diterpene.
From an ethanol extract of the stems of Burasaïa madagascarensis Thouars (Menispermaceae) were isolated N-acetylnornuciferine and two clerodane-type diterpenes, one of them, epicordatine, being new. The structures were established by the interpretation of the spectral data. All the described compounds exhibited weak antimalarial activity.
Mambu
Lengo
L
Ramanandraibe
Voahangy
V
Martin
Marie Thérèse
MT
Blond
Alain
A
Grellier
Philippe
P
Frappier
François
F
D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045785:Diterpenes, Clerodane; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D019271:Hypoxanthine / Q000493:pharmacokinetics; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000378:metabolism; D014316:Tritium
D004224:Diterpenes; D045785:Diterpenes, Clerodane; D005663:Furans; D010936:Plant Extracts; C459632:epicordatine; C459633:penianthic acid, methyl ester; D014316:Tritium; D019271:Hypoxanthine