[Multifocal tuberculosis: fatal outcome due to toxic drug reactions].
We report a case of multifocal tuberculosis with the following features: - skin involvement with multiple gommes disseminated on the left upper limb, the left flank, the right hypocondrium, and the right leg; - nodal involvement including the left supraclavicular, left axillary, right laterotracheal, pre and subcarineal, ceoeliomesenteric, and liver hilus nodes; splenic involvement; right pleural involvement; - spondylodiscitis of T11-T12 and of the head of the right fibula; - peritoneal involvement leading to ascitis; - multi-organ involvement. This 43-year-old woman had not particular history: no diabetes, no renal failure, no long-term corticosteroid treatment, no immunosuppressor treatment, negative HIV-1 and HIV-2 serology. Treatment with anti-tuberculosis agents led to severe drug reactions causing death due to hepatic encephalitis.
Elouazzani
H
H
Service de Pneumologie, Hôpital Militaire d'Instruction Mohammed-V, Rabat, Maroc.
Bouchentouf
R
R
Rguibi
M
M
Rhorfi
I
I
Ouarssani
A
A
Yassir
Z
Z
Abid
A
A
Alaoui-Tahiri
K
K
D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D006501:Hepatic Encephalopathy / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D014391:Tuberculosis, Miliary / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology
D000995:Antitubercular Agents