Buerger's disease and anticardiolipin antibodies: a worse prognosis?
The case of a 26-year-old male chronic smoker is reported, who had thrombotic incidences on three occasions in both upper and lower limbs over a 10-month period. Laboratory examinations, including hematologic studies and creatinine, cholesterol, and glucose levels, were normal. However, IgG and IgM anticardiolipin antibodies were detected. Duplex ultrasonography confirmed deep venous thrombosis in both lower limbs (two occurrences) and computer tomography depicted an inferior cava vein thrombosis. The patient fulfilled all of Shionoya's criteria for Buerger's disease, thus suggesting an association between anticardiolipin antibodies and this disease.
de Godoy
José Maria Pereira
JM
Department of Cardiology and Vascular Surgery, São José do Rio Preto, University School of Medicine, São Paulo, Brazil. godoyjmp@riopreto.com.br
Braile
Domingo Marcolino
DM
Godoy
Moacir Fernandes
MF
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011379:Prognosis; D011928:Raynaud Disease / Q000209:etiology; D012907:Smoking / Q000009:adverse effects; D016540:Smoking Cessation; D013919:Thromboangiitis Obliterans / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000628:therapy; D013924:Thrombophlebitis / Q000209:etiology; D014859:Warfarin / Q000627:therapeutic use
D017153:Antibodies, Anticardiolipin; D000925:Anticoagulants; D014859:Warfarin; D006493:Heparin