Antifungal activity of 5 new synthetic compounds vs. Trichophyton rubrum and Epidermophyton floccosum.
The antifungal activity of five new synthetic compounds was evaluated on two dermatophytes: Epidermophyton floccosum and Trichophyton rubrum. The data showed that the imidazo-pyrazole and pyrazolo-thiazoles were not particularly effective, while the two pyrazole-thiocyanates proved highly active on both fungi. The most active 5-amino-3-methyl-1-phenylpyrazolo-4-thiocyanate was chosen to perform SEM and TEM morphological studies on both fungi. Both SEM and TEM observations revealed interesting alterations on the two dermatophytes, particularly involving the endomembrane system.
Romagnoli
C
C
Department of Animal Biology, University of Modena e Reggio Emilia, Italy.
Mares
D
D
Bruni
A
A
Andreotti
E
E
Manfrini
M
M
Vicentini
C B
CB
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004821:Epidermophyton / Q000187:drug effects* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*; D013861:Thiocyanates / Q000737:chemistry / Q000494:pharmacology*; D014249:Trichophyton / Q000187:drug effects* / Q000648:ultrastructure
D000935:Antifungal Agents; D011720:Pyrazoles; D013861:Thiocyanates