(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-perhydro-1,4-oxazine-2,5-dione: an apoptosis-inducer from the fruiting bodies of Isaria japonica.
(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione (1) was isolated from the fruiting bodies of Isaria japonica as an apoptosis-inducing agent. The complete structural assignment of the compound was accomplished on the basis of spectroscopic methods and chemical transformations. Compound 1 induced apoptotic cell death of the human leukemia cells (HL-60) in a dose-dependent manner, ranging from 5.0 microg/ml to 100.0 microg/ml.
Oh
Hyuncheol
H
Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Republic of Korea.
Kim
Taewan
T
Oh
Gi-Su
GS
Pae
Hyun-Ock
HO
Hong
Kyung-Hwan
KH
Chai
Kyu-Yun
KY
Kwon
Tae-Oh
TO
Chung
Hun-Taeg
HT
Lee
Ho-Sub
HS
D017209:Apoptosis / Q000187:drug effects*; D001203:Ascomycota; D004305:Dose-Response Relationship, Drug; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009025:Morpholines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012098:Reproduction
C459624:4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione; D009025:Morpholines; C085610:lateritin