Serum concentrations of markers of type I collagen metabolism in women taking monophasic oral contraceptives.
OBJECTIVE
To investigate serum concentrations of the carboxy-terminal propeptide of type I procollagen (PICP) and cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), reflecting the rate of synthesis and degradation of the parent collagen respectively, in women using monophasic oral contraceptives.


METHODS
PICP and ICTP were estimated in 60 women taking 20 micrograms of ethinyl estradiol (EE) + 150 micrograms of desogestrel (DSG) or 30 micrograms of EE + 150 micrograms DSG over six months.


RESULTS
Mean PICP concentration decreased in women receiving 20 micrograms of EE + 150 infinity g of DSG after three cycles of administration. However, after six months this value returned to a level comparable to the initial one. In women taking 30 micrograms of EE + 150 micrograms of DSG the mean concentrations of PICP did not change significantly throughout the period studied. None of the oral contraceptives noticeably influenced the concentrations of ICTP.


CONCLUSIONS
Investigated oral contraceptives do not significantly affect the metabolism of type I collagen, however a transient decrease in its biosynthesis may be expected during the use of formulations containing 20 micrograms of EE.
Rechberger
Tomasz
T
Kliniki Ginekologii Operacyjnej II Katedry Połoznicwa i Chorób Kobiecych Akademii Medycznej w Lublinie.
Baranowski
Włodzimierz
W
Bogusiewicz
Michał
M
Postawski
Krzysztof
K
Jakimiuk
Artur J
AJ
Tomaszewski
Jacek
J
Kulik-Rechberger
Beata
B
Jakowicki
Jerzy A
JA
D000328:Adult; D015415:Biomarkers / Q000097:blood; D024042:Collagen Type I; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage*; D017135:Desogestrel / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D010197:Pancuronium / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides; D011347:Procollagen / Q000097:blood*
D015415:Biomarkers; D024042:Collagen Type I; D003280:Contraceptives, Oral, Synthetic; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C042813:procollagen type I carboxy terminal peptide; D017135:Desogestrel; D010197:Pancuronium; C003549:dacuronium