Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2.
1. Protease-activated receptor 2 (PAR2), present in capsaicin-sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection. 2. We studied the possible cross-talk between PAR2 and vanilloid receptor 1 (VR1). The VR1 antagonist capsazepine partially inhibited the PAR2-mediated increase in gastric mucus secretion. 3. Thus, activation of VR1 is responsible, at least in part, for the neurally mediated mucosal cytoprotection following activation of PAR2.
Kawabata
Atsufumi
A
Faculty of Pharmaceutical Sciences, Kinki University, Higashi-Osaka, Japan. kawabata@phar.kindai.ac.jp
Kinoshita
Mitsuhiro
M
Kuroda
Ryotaro
R
Kakehi
Kazuaki
K
D000818:Animals; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism*; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D009475:Neurons, Afferent / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D044464:Receptor, PAR-2; D011955:Receptors, Drug / Q000378:metabolism; D018179:Receptors, Thrombin / Q000378:metabolism*; D050916:TRPV Cation Channels
D044464:Receptor, PAR-2; D011955:Receptors, Drug; D018179:Receptors, Thrombin; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; C071423:capsazepine; D002211:Capsaicin