Repeated imipramine administration enhances the effects of NMDA receptor ligands on synchronous activity in rat frontal cortex in vitro.
This study assessed the effects of repeated administration (14 days) of imipramine on the function of NMDA receptors by measuring the frequency of spontaneous epileptiform discharges which develop in rat frontal cortical slices incubated in Mg2+-free conditions. Imipramine significantly enhanced both the excitatory effect of NMDA and the inhibitory effect of the competitive NMDA receptor antagonist CGP 37849 on the frequency of discharges. These results are consistent with studies indicating that chronic administration of antidepressant drugs induces adaptive changes in NMDA receptor/ channel complex in the cerebral cortex.
Bobula
B
B
Department of Physiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków. bobula@if-pan.krakow.pl
Tokarski
K
K
Hess
G
G
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D003344:Cortical Synchronization / Q000187:drug effects*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D007099:Imipramine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008024:Ligands; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology; D009473:Neuronal Plasticity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects* / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects
D000929:Antidepressive Agents, Tricyclic; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D008024:Ligands; D016194:Receptors, N-Methyl-D-Aspartate; C064539:2-amino-4-methyl-5-phosphono-3-pentenoic acid; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D007099:Imipramine