title: Studies toward the total synthesis of gymnocin A, a cytotoxic polyether: a highly convergent entry to the F-N ring fragment.
abstract: [structure: see text] An efficient and highly convergent synthesis of the FGHIJKLMN ring fragment of gymnocin A, a cyctotoxic polycyclic ether isolated from the notorious red-tide forming dinoflagellate Gymnodinium mikimotoi, has been achieved. The present synthesis relied on extensive use of the B-alkyl Suzuki-Miyaura coupling reaction.
authors: Department of Chemistry, Graduate School of Science, The University of Tokyo, Japan. msasaki@bios.tohoku.ac.j
authors: Makoto
authors: M
authors: Sasaki
authors: Chihiro
authors: C
authors: Tsukano
authors: Kazuo
authors: K
authors: Tachibana
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D004141:Dinoflagellida / Q000187:drug effects*; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000302:isolation & purification; D007202:Indicators and Reagents; D008958:Models, Molecular
chemical_list: D000970:Antineoplastic Agents; D004988:Ethers, Cyclic; D007202:Indicators and Reagents; C458159:gymnocin A