title: Myeloma-associated systemic amyloidosis presenting with acquired digital cutis laxa-like changes.
abstract: A 59-year-old woman presented with a 6-year history of lax skin on the distal fingers of both hands, as well as a recent increase in the size of her tongue. Histopathology of skin from her distal finger showed amyloid deposition and bone marrow biopsy revealed an underlying plasma cell dyscrasia. Initial treatment with cyclophosphamide, vincristine, adriamycin and methylprednisolone has produced a significant reduction in the swelling of both her hands and tongue. Acquired digital cutis laxa-like changes are a rare cutaneous manifestation of systemic amyloidosis.
authors: Department of Dermatology, Royal Brisbane Hospital, Post Office, Herston, Queensland 4029, Australia. tdicker@bigpond.net.au
authors: Tony J
authors: TJ
authors: Dicker
authors: James
authors: J
authors: Morton
authors: Richard M
authors: RM
authors: Williamson
authors: Jeff
authors: J
authors: Chick
mesh_terms: D000686:Amyloidosis / Q000150:complications* / Q000473:pathology; D003483:Cutis Laxa / Q000150:complications* / Q000473:pathology; D005260:Female; D006229:Hand Dermatoses / Q000150:complications* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications*; D012867:Skin / Q000473:pathology