Use of proligestone in the management of three German shepherd dogs with pituitary dwarfism.
Three German shepherd dogs were diagnosed with pituitary dwarfism and subsequently treated with proligestone. Treatment resulted in development of an adult hair coat, increased bodyweight and elevated insulin-like growth factor-1 concentration. Two dogs received thyroid supplementation during proligestone therapy. Adverse effects (cystic endometrial hyperplasia and acromegaly) were reported in two cases. No side effects were reported in the remaining case. This is the first report of the use of proligestone in the management of pituitary dwarfism.
Knottenbelt
C M
CM
Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden.
Herrtage
M E
ME
D000172:Acromegaly / Q000139:chemically induced / Q000662:veterinary; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004393:Dwarfism, Pituitary / Q000188:drug therapy / Q000662:veterinary*; D004714:Endometrial Hyperplasia / Q000139:chemically induced / Q000662:veterinary; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006197:Hair / Q000187:drug effects; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D011374:Progesterone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D045167:Progesterone Congeners / Q000627:therapeutic use*
D045167:Progesterone Congeners; D011374:Progesterone; C017677:proligestone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone