title: Photochromic nucleic base units suitable for nucleic acid labelling.
abstract: New molecules incorporating a uracil nucleic base and a dihydroindolizine (DHI) unit linked via spacer arms, i.e., uracil-spyrodihydroindolizine (4), were synthesised as models for light sensitive systems for nucleic acid labelling. The uracil-DHI (4) undergoes easy photocoloration to the uracil-betaine (5) generating the UV-detectable species. Preliminary results show rather weak binding of uracil-DHI (4) to calf thymus-DNA.
authors: Universität des Saarlandes, Fakultät 8.12, Organische Chemie, Im Stadtwald, D-66123, Saarbrücken, Germany.
authors: Eliso
authors: E
authors: Gogritchiani
authors: Thomas
authors: T
authors: Hartmann
authors: Barbara Susanne
authors: BS
authors: Palm
authors: Shota
authors: S
authors: Samsoniya
authors: Heinz
authors: H
authors: Dürr
mesh_terms: D000818:Animals; D001622:Betaine / Q000737:chemistry; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D007212:Indolizines / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000737:chemistry*; D013950:Thymus Gland / Q000737:chemistry*; D014498:Uracil / Q000031:analogs & derivatives / Q000737:chemistry*
chemical_list: D007212:Indolizines; D017319:Photosensitizing Agents; C467358:uracil-spyrodihydroindolizine; D001622:Betaine; D014498:Uracil; D004247:DNA