title: [Histocompatibility HLA system of man. Considerations in the light of current concepts. VII. Nonclassical HLA- E, F, and H loci].
abstract: Current opinions connected with HLA-E and HLA-F genes determining "nonclassical" (HLA-Ib) class I antigens of the Main Histocompatibility Complex MHC, and formed in the consequence of mutation or partial deletion of HLA-H pseudogene loci were presented. The expression of protein products of HLA-E and -F genes on some cells and tissues, their polymorphism, and also their biological functions in organisms were qualified by the use of molecular technics. The kind and frequency of occurrence of mutations 845 A (C282Y) and 187 G (H63D) in gene HLA-H were analysed, and in this context some genetic aspects of hereditary hemochromatozy (HH) were discussed.
authors: Samodzielna Pracownia Immunologii Klinicznej Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
authors: A
authors: A
authors: Kedzierska
authors: G
authors: G
authors: Turowski
mesh_terms: D005786:Gene Expression Regulation; D005805:Genes, MHC Class I / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics*; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins; D009154:Mutation; D000097625:HLA-E Antigens
chemical_list: D006680:HLA Antigens; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D000097625:HLA-E Antigens; C103673:HFE protein, human; C062341:HLA-F antigens