Stereospecific synthesis of cryptophycin 1.
[reaction: see text] A brief stereospecific synthesis of cryptophycin 1 is described in which (R)-mandelic acid serves as the sole source of asymmetry for unit A. The key step is a hetero-Diels-Alder cycloaddition.
Li
Lian-Hai
LH
Department of Chemistry, 2545 The Mall, University of Hawaii, Honolulu 96822, USA.
Tius
Marcus A
MA
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D000458:Cyanobacteria / Q000737:chemistry; D003500:Cyclization; D047630:Depsipeptides; D007202:Indicators and Reagents; D008333:Mandelic Acids / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D047630:Depsipeptides; D007202:Indicators and Reagents; D008333:Mandelic Acids; D010456:Peptides, Cyclic; C088419:cryptophycin; C037938:mandelic acid