title: Body mass index in relation to ovarian cancer: a multi-centre nested case-control study.
abstract: The incidence of ovarian cancer is up to 10 times higher in Western countries than in rural Asia and Africa. One common consequence of a Western lifestyle is the development of excessive body weight and obesity. A multi-centre prospective study was conducted to investigate the association between body mass index (BMI) and ovarian cancer risk. A case-control study was nested within 3 prospective cohorts in New York (USA), Umeå (Sweden) and Milan (Italy). Information on anthropometry, demographic characteristics, medical history and lifestyle was obtained at the time of subjects' recruitment in each cohort. Women diagnosed with primary, invasive epithelial ovarian cancer from the 3 cohorts (n = 122) diagnosed 12 months or later after recruitment into the respective cohort served as case subjects. For each case subject, 2 control subjects that matched the case subject on cohort, menopausal status, age and date of recruitment were randomly identified. Data were analyzed by conditional logistic regression. There was an inverse association between BMI and ovarian cancer risk. For increasing quartiles of BMI above the lowest, the ORs were 0.62 (0.32-1.21), 0.59 (0.30-1.17) and 0.46 (0.23-0.92), p = 0.03. Analyses limited to women diagnosed 3 or more years after recruitment into the cohorts did not alter these findings. When obese women (BMI > 30) were compared to lean women (BMI < or = 23), the inverse association became stronger, with an OR of 0.38 (0.17-0.85), p < 0.02. There was some evidence of direct association of ovarian cancer with height, which was limited to cancers diagnosed before age 55. Our data suggest that increasing body weight may confer a protection against ovarian cancer.
authors: Department of Nutrition and Cancer, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon, France. lukanova@iarc.fr
authors: Annekatrin
authors: A
authors: Lukanova
authors: Paolo
authors: P
authors: Toniolo
authors: Eva
authors: E
authors: Lundin
authors: Andrea
authors: A
authors: Micheli
authors: Arslan
authors: A
authors: Akhmedkhanov
authors: Paola
authors: P
authors: Muti
authors: Anne
authors: A
authors: Zeleniuch-Jacquotte
authors: Carine
authors: C
authors: Biessy
authors: Per
authors: P
authors: Lenner
authors: Vittorio
authors: V
authors: Krogh
authors: Franco
authors: F
authors: Berrino
authors: Goran
authors: G
authors: Hallmans
authors: Elio
authors: E
authors: Riboli
authors: Rudolf
authors: R
authors: Kaaks
mesh_terms: D000328:Adult; D000367:Age Factors; D001827:Body Height; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009765:Obesity; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000473:pathology*; D012307:Risk Factors