Supplemental fructooligosaccharides and mannanoligosaccharides influence immune function, ileal and total tract nutrient digestibilities, microbial populations and concentrations of protein catabolites in the large bowel of dogs.
The goal of this study was to examine whether supplemental fructooligosaccharides (FOS) and (or) mannanoligosaccharides (MOS) influenced indices of gut health of dogs. Adult female dogs (n = 4) surgically fitted with ileal cannulas were fed a dry, extruded, kibble diet twice daily. At each feeding, the following treatments were administered: 1) Control (no FOS or MOS); 2) 1 g FOS; 3) 1 g MOS; or 4) 1 g FOS + 1 g MOS. Fecal, ileal and blood samples were collected during the last 4 d of each 14-d period to measure protein catabolite concentrations, microbial populations, immune characteristics and nutrient digestibilities. Treatment means were compared using preplanned orthogonal contrasts. Dogs supplemented with MOS had lower (P = 0.05) fecal total aerobes and tended to have greater (P = 0.13) Lactobacillus populations. Ileal immunoglobulin (Ig) A concentrations were greater (P = 0.05) in dogs supplemented with FOS + MOS vs. control. Lymphocytes (% of total white blood cells) were greater (P < 0.05) in dogs supplemented with MOS. Serum IgA concentrations also tended (P = 0.13) to be greater in dogs supplemented with MOS. Dogs supplemented with FOS and FOS + MOS had lower (P < 0.05) fecal total indole and phenol concentrations. Dogs supplemented with MOS tended to have lower ileal DM (P = 0.149) and OM (P = 0.146) digestibilities vs. control. Results of this study suggest that dietary supplementation of FOS and MOS may have beneficial effects on colonic health and immune status of dogs.
Swanson
Kelly S
KS
Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA.
Grieshop
Christine M
CM
Flickinger
Elizabeth A
EA
Bauer
Laura L
LL
Healy
Hans-Peter
HP
Dawson
Karl A
KA
Merchen
Neal R
NR
Fahey
George C
GC
D000818:Animals; D001419:Bacteria / Q000254:growth & development; D002404:Catheterization; D003106:Colon / Q000378:metabolism / Q000382:microbiology; D019587:Dietary Supplements; D004063:Digestion / Q000187:drug effects; D004285:Dogs / Q000378:metabolism* / Q000382:microbiology; D005227:Fatty Acids / Q000378:metabolism; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D005260:Female; D007082:Ileum / Q000276:immunology / Q000378:metabolism*; D007070:Immunoglobulin A / Q000032:analysis; D008351:Mannans / Q000008:administration & dosage / Q000378:metabolism; D009844:Oligosaccharides / Q000008:administration & dosage* / Q000378:metabolism; D011506:Proteins / Q000032:analysis / Q000378:metabolism*
D005227:Fatty Acids; D007070:Immunoglobulin A; D008351:Mannans; D009844:Oligosaccharides; D011506:Proteins; C116580:fructooligosaccharide