Effect of KAD-1229, a novel hypoglycaemic agent, on plasma glucose levels after meal load in type 2 diabetic rats.
1. The effects of KAD-1229 (a novel non-sulphonylurea agent), voglibose (an alpha-glucosidase inhibitor) and nateglinide (a non-sulphonylurea antihyperglycaemic agent) on hyperglycaemia induced by a meal load were assessed in diabetic rats. 2. KAD-1229 suppressed the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load. 3. Voglibose also suppressed the increase in plasma glucose levels; however, a significant decrease in AUCglucose following voglibose was not observed. 4. Nateglinide suppressed the increase in plasma glucose levels at 30 min and 1 h after the meal load; however, plasma glucose levels was above control thereafter and the AUCglucose was not decreased. 5. The results indicate that KAD-1229 has an antihyperglycaemic effect and KAD-1229 is suggested to be a suitable agent for controlling post-prandial hyperglycaemia.
Ichikawa
Kiyoshi
K
Pharmacology Laboratories, Kissei Pharmaceutical Co. Ltd, Hotaka, Nagano, Japan. kiyoshi_ichikawa@pharm.kissei.co.jp
Yamato
Tokuhisa
T
Ojima
Kazuma
K
Tsuji
Atsutoshi
A
Ishikawa
Kohtaro
K
Kusama
Hiroshi
H
Kojima
Masami
M
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003510:Cyclohexanes / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D005502:Food; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D007294:Inositol / Q000031:analogs & derivatives* / Q000494:pharmacology; D054833:Isoindoles; D000077715:Nateglinide; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D019518:Postprandial Period; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
D001786:Blood Glucose; D003510:Cyclohexanes; D007004:Hypoglycemic Agents; D007211:Indoles; D054833:Isoindoles; D000077715:Nateglinide; D010649:Phenylalanine; D007294:Inositol; C087255:mitiglinide; C102817:voglibose