Giant coronary aneurysms due to Kawasaki disease: a case-control study.
BACKGROUND
Epidemiologic features of giant coronary aneurysm due to Kawasaki disease and its risk factors are still not clear.


METHODS
Sixty-six patients with giant coronary aneurysms were reported to a 15th nationwide survey of Kawasaki disease in Japan. With all other patients treated in the same hospital as a control group, odds ratios were calculated for certain potential risk factors.


RESULTS
Infant males aged less than 1 year,neutrophil concentration among leukocyte, late administration of intravenous gammaglobulin (IVGG) therapy and additional administration of IVGGwere considered as risk factors of giant coronary aneurysms due to Kawasaki disease. In univariate analysis, use of IVGG therapy and a large amount of IVGG (2500+ mg/kg)elevated the risk, whereas the relationship disappeared after the adjustment.


CONCLUSIONS
The observation of 66 cases with giant coronary aneurysms due to Kawasaki disease reported to the nationwide survey provides some risk factors and consideration about the aneurysms.
Nakamura
Yosikazu
Y
Department of Public Health, Jichi Medical School,Tochigi, Japan. nakamuyk@jichi.ac.jp
Yashiro
Mayumi
M
Oki
Izumi
I
Tanihara
Shinichi
S
Ojima
Toshiyuki
T
Yanagawa
Hiroshi
H
D016022:Case-Control Studies; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000209:etiology*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D016017:Odds Ratio; D012307:Risk Factors
D016756:Immunoglobulins, Intravenous