title: Apparent replication of suggestive linkage on chromosome 16 in the NIMH genetics initiative bipolar pedigrees.
abstract: Analyses of a replication sample of families collected as part of the National Institute of Mental Health (NIMH) Genetics Initiative for bipolar disorder provide further evidence for linkage to a region of chromosome 16. Families who had a bipolar I (BPI) proband and at least one BPI or schizoaffective, bipolar type (SABP) first-degree relative were ascertained for the purpose of identifying genes involved in bipolar affective disorder. A series of hierarchical models of affected status was used in linkage analyses. Initial genetic analyses of chromosomes 3, 5, 15, 16, 17, and 22, completed at Indiana University in 540 subjects from 97 families, suggested evidence of linkage to chromosomes 5, 16, and 22 [Edenberg et al., 1997: Am J Med Genet 74:238-246]. Genotyping was subsequently performed on these chromosomes in a replication sample of 353 individuals from 56 families. Nonparametric linkage analyses were performed using both affected relative and sibling pair methods. Analyses in the new sample on chromosome 16, using the broadest model of affected status, corroborate previously reported suggestive linkage to the marker D16S2619. Combining the initial and replication samples further increased the evidence of linkage to this region, with a peak lod score of 2.8.
authors: Indiana University School of Medicine, Indianapolis, Indiana 46202-4887, USA.
authors: Danielle M
authors: DM
authors: Dick
authors: Tatiana
authors: T
authors: Foroud
authors: Howard J
authors: HJ
authors: Edenberg
authors: Marvin
authors: M
authors: Miller
authors: Elizabeth
authors: E
authors: Bowman
authors: N Leela
authors: NL
authors: Rau
authors: J Raymond
authors: JR
authors: DePaulo
authors: Melvin
authors: M
authors: McInnis
authors: Elliot
authors: E
authors: Gershon
authors: Francis
authors: F
authors: McMahon
authors: John P
authors: JP
authors: Rice
authors: Laura J
authors: LJ
authors: Bierut
authors: Theodore
authors: T
authors: Reich
authors: John
authors: J
authors: Nurnberger
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree