Xenon chloride ultraviolet B laser is more effective in treating psoriasis and in inducing T cell apoptosis than narrow-band ultraviolet B.
Earlier we reported that a 308-nm xenon chloride (XeCl) UVB laser is highly effective for treating psoriasis. As ultraviolet B light seems to cause T cell apoptosis, in the present study we studied the ability of the XeCl laser to induce T-cell apoptosis in vitro, and then compared the apoptosis-inducing capacities of narrow-band UVB (NB-UVB) light and the XeCl laser. The role of laser impulse frequency and intensity in the therapeutical and apoptosis-inducing efficacy of XeCl laser was also investigated. Both XeCl laser and NB-UVB induced T cell apoptosis, but quantitative induction was greater with XeCl laser. Changes in the frequency and intensity of impulses of XeCl laser did not influence its therapeutic and T cell apoptosis-inducing efficacy. These results suggest that the more effective induction of T cell apoptosis can be responsible for the greater clinical efficacy of XeCl laser compared to NB-UVB. Additionally, the optical properties of the XeCl laser (a monochromatic, coherent, pulse-mode laser; easier precise dosimetry, there are no 'contaminating' wavelengths) can make this laser light an ideal tool for studies of the mode of action of UVB light.
Novák
Zoltán
Z
Department of Dermatology, University of Szeged, P.O. Box 427, H-6701, Szeged, Hungary.
Bónis
Béla
B
Baltás
Eszter
E
Ocsovszki
Imre
I
Ignácz
Ferenc
F
Dobozy
Attila
A
Kemény
Lajos
L
D017209:Apoptosis; D002712:Chlorides / Q000627:therapeutic use*; D006801:Humans; D007834:Lasers; D011565:Psoriasis / Q000532:radiotherapy*; D013601:T-Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D014466:Ultraviolet Rays; D014978:Xenon / Q000627:therapeutic use*
D002712:Chlorides; D014978:Xenon; C048006:xenon chloride