title: Holding power of bioabsorbable ciprofloxacin-containing self-reinforced poly-L/DL-lactide 70/30 bioactive glass 13 miniscrews in human cadaver bone.
abstract: Antibiotics-plus bioactive glass-containing bioabsorbable self-reinforced (SR) polylactide screws have been developed for antibacterial osteoconductive bone fixation. The aim of the present study was to test the pullout properties of these recently developed miniscrews. Ciprofloxacin-plus bioactive glass-containing SR-polylactide miniscrews (BC) were compared with miniscrews made of neat SR-polylactide (A), SR-polylactide with bioactive glass (B), and ciprofloxacin-containing SR-polylactide (C). BC miniscrews and their controls (A, B, C) (all of length 6.0 mm, core diameter 1.45 mm, thread diameter 2.0 mm) were applied to one pair of cadaveric fibulae. Pullout force was measured using a materials testing machine. We carried out 49-50 pullout tests for each implant type. The Mann-Whitney test and Student's t-test were used for statistical evaluation. The pullout force for BC miniscrews was 114.9 +/- 34.0 (SD) N. Pullout forces for control miniscrews were 162.7 +/- 37.8 N (A), 99.1 +/- 16.2 N (B), and 142.9 +/- 26.9 N (C). Differences between the four groups were statistically significant (p < 0.001). Ciprofloxacin-plus bioactive glass-containing polylactide miniscrews have good holding power to human cadaver fibulae. However, adding bioactive glass and ciprofloxacin components to neat SR-polylactide results in lower pullout values.
authors: Department of Surgery, Oulu University Hospital, PO Box 21, FIN-90029 OYS, Oulu, Finland. stleino@cc.oulu.fi
authors: Sanna
authors: S
authors: Leinonen
authors: Esa
authors: E
authors: Suokas
authors: Minna
authors: M
authors: Veiranto
authors: Pertti
authors: P
authors: Törmälä
authors: Timo
authors: T
authors: Waris
authors: Nureddin
authors: N
authors: Ashammakhi
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001672:Biocompatible Materials; D001863:Bone Screws; D002516:Ceramics; D002939:Ciprofloxacin / Q000627:therapeutic use*; D003799:Dental Stress Analysis; D020878:Device Removal; D005360:Fibula; D006801:Humans; D008297:Male; D008422:Materials Testing; D010019:Osteomyelitis / Q000517:prevention & control; D011091:Polyesters; D018709:Statistics, Nonparametric; D013718:Tensile Strength
chemical_list: D000890:Anti-Infective Agents; D001672:Biocompatible Materials; C022107:Bioglass; D011091:Polyesters; C033616:poly(lactide); D002939:Ciprofloxacin