Modulation of insulin signaling in human skeletal muscle in response to exercise.
Exercise is widely recommended for the treatment of obesity, insulin resistance, and type II diabetes mellitus. Recent discoveries in the molecular and cellular regulation of insulin-mediated glucose metabolism in skeletal muscle have provided a deeper understanding of how exercise modulates insulin action.
Kirwan
John P
JP
Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, Ohio 44109-1998, USA. jpk10@po.cwru.edu
Jing
Ming
M
D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D015444:Exercise / Q000502:physiology*; D006006:Glycogen Synthase / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance / Q000502:physiology; D018482:Muscle, Skeletal / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D007328:Insulin; D006006:Glycogen Synthase; D019869:Phosphatidylinositol 3-Kinases