5-HT1A receptor immunoreactivity in hypothalamic neurons involved in body weight control.
Serotonin (5-hydroxytryptamine; 5-HT) is a regulator of feeding behavior. The effect of serotonin on food intake is believed to be primarily mediated via 5-HT(1A) and 5-HT(2C) receptors, which both are expressed in hypothalamic regions implicated in regulation of feeding behavior. Using an antiserum to the 5-HT(1A) receptor, immunoreactive neurons were observed in the rat supraoptic, paraventricular, arcuate and ventromedial nuclei and lateral hypothalamic area. 5-HT(1A) receptor immunoreactivity was demonstrated in neuropeptide Y-, agouti-related peptide-, proopiomelanocortin- and cocaine- and amphetamine-regulated transcript-containing neurons of the arcuate nucleus. In the lateral hypothalamus, 5-HT(1A) receptor immunoreactivity was observed in melanin-concentrating hormone- and orexin-containing neurons. The results suggest that serotonin via postsynaptic 5-HT(1A) receptors affects the release of peptides regulating food intake.
Collin
Maria
M
Department of Neuroscience, The Retzius Laboratory, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Bäckberg
Matilda
M
Onnestam
Kristin
K
Meister
Björn
B
D000818:Animals; D001835:Body Weight / Q000502:physiology*; D006168:Guinea Pigs; D007031:Hypothalamus / Q000737:chemistry* / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000737:chemistry* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000032:analysis* / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1
D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1