Influence of new gamma-aminobutyric acid amide derivatives and its phthalimide precursors on the central nervous system activity in mice.
The present study investigated the influence of BM-78, BM-121 (gamma-aminobutyric acid amide derivatives) and BM-42, BM-43 (phthalimide precursors of BM-78 and BM-121) on the spontaneous locomotor activity and on the picrotoxin-induced seizures. Results of pharmacological in vivo examination of the effects of new gamma-aminobutyric acid amide derivatives and its phthalimide precursors (compounds BM-78, BM-121, BM-42, BM-43), presented in this paper showed that all the compounds had different but clear influence on CNS in mice.
Mendyk
A
A
Department of Pharmacodynamics, Jagiellonian University, Medical College, Kraków, Poland.
Sałat
K
K
Librowski
T
T
Czarneck
R
R
Malawska
B
B
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D018756:GABA Antagonists; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010797:Phthalimides / Q000737:chemistry / Q000494:pharmacology*; D010852:Picrotoxin; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
D000927:Anticonvulsants; D018756:GABA Antagonists; D010797:Phthalimides; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid