No association between DCP1 genotype and late-onset Alzheimer disease.
In a study of 261 patients with Alzheimer disease (AD) and 306 cognitively normal control subjects from Germany, Switzerland, and Italy, we found no association between genotype counts or allelic frequencies of DCP1, the gene encoding angiotensin-converting enzyme. In accordance with several other studies, our data could not confirm previous association findings. Critical review about all studies available on DCP1 genotyping and AD, age-associated cognitive decline, longevity, and other conditions revealed remarkable inconsistencies. Several studies showed significant deviations of genotype counts from Hardy Weinberg equilibrium (HWE). Deviations from HWE may limit the comparability of study results and require clarification before drawing conclusions with respect to disease risk, health conditions, or longevity in association with DCP1 genotype.
Buss
Svenja
S
Department of Human Genetics, University Hospital Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.
Müller-Thomsen
Tomas
T
Hock
Cristoph
C
Alberici
Antonella
A
Binetti
Giuliano
G
Nitsch
Roger M
RM
Gal
Andreas
A
Finckh
Ulrich
U
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*
D001057:Apolipoproteins E; D007703:Peptidyl-Dipeptidase A