title: [Morphological and cytogenetic disorders in rats following chronic exposure to elevated radiation].
abstract: Object of the investigation were effects of elevated radiation background on specific body systems in two generations of rats that had been chronically exposed to radiation in the most badly polluted areas of the Kaluga district and eaten local food. Findings included some compensatory deviations in the white blood count, decrease in karyocytes and increase in chromosomal aberration rate in nucleus-containing cells from the femoral bone marrow in younger animals of several groups, morphologic and histochemical shifts in mucous membrane of the esophagus and the stomach, and morphofunctional changes in neurons and glia of the cerebral cortex. These changes are compensatory-adaptive by nature and indicative of destabilization of homeostasis in experimental animals.
authors: B S
authors: BS
authors: Fedorenkjo
authors: A V
authors: AV
authors: Ershov
authors: N P
authors: NP
authors: Shcherbak
authors: A N
authors: AN
authors: Abrosimova
authors: N N
authors: NN
authors: Budennaia
authors: S V
authors: SV
authors: Vorozhtsova
authors: R A
authors: RA
authors: Druzhit'eva
authors: M Iu
authors: MIu
authors: Muratova
authors: S N
authors: SN
authors: Shcherbak
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism / Q000528:radiation effects; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000473:pathology* / Q000528:radiation effects*; D002869:Chromosome Aberrations / Q000528:radiation effects*; D002908:Chronic Disease; D003582:Cytogenetics / Q000379:methods*; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology / Q000473:pathology / Q000528:radiation effects; D006706:Homeostasis / Q000528:radiation effects; D007962:Leukocytes / Q000473:pathology* / Q000528:radiation effects*; D008297:Male; D008938:Mitosis / Q000528:radiation effects; D009457:Neuroglia / Q000473:pathology* / Q000528:radiation effects*; D011832:Radiation Injuries / Q000150:complications*; D051381:Rats; D013953:Thymus Neoplasms / Q000209:etiology* / Q000473:pathology; D013997:Time Factors
chemical_list: D000110:Acetylcholinesterase