[The roles of the prostanoids played in the body].
The actions of prostanoids in various physiological and pathophysiological conditions have been examined using mice lacking the prostanoid receptors. PGD2 was found to be a mediator of allergic asthma. Prostaglandin (PG) I2 worked not only as a mediator of inflammation but also as an antithrombotic and cardio-protective agent. Several important actions of PGE2 are brought out via the PGE2-receptor subtype EP3; PGE2 participated in the regulation of platelet function, and it worked as a mediator of febrile responses to both endogenous and exogenous pyrogens. These novel findings on the roles of the prostanoids would contribute to the development of drugs targeting the prostanoid receptors.
Ushikubi
Fumitaka
F
Department of Pharmacology, Asahikawa Medical College, Midorigaoka-Higashi 2-1-1-1, Asahikawa 078-8510, Japan.
Narumiya
Shuh
S
D000818:Animals; D001249:Asthma / Q000209:etiology; D015232:Dinoprostone / Q000502:physiology; D015195:Drug Design; D011464:Epoprostenol / Q000502:physiology; D005334:Fever / Q000209:etiology; D006801:Humans; D018836:Inflammation Mediators; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D015539:Platelet Activation; D015230:Prostaglandin D2 / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology*; D011982:Receptors, Prostaglandin / Q000502:physiology; D013927:Thrombosis / Q000209:etiology
D018836:Inflammation Mediators; D011453:Prostaglandins; D011982:Receptors, Prostaglandin; D011464:Epoprostenol; D015232:Dinoprostone; D015230:Prostaglandin D2