An association of CAG repeats at the KCNN3 locus with symptom dimensions of schizophrenia.
BACKGROUND
In 1999 Cardno et al reported that long CAG repeats in the calcium-activated potassium channel gene hSKCa3/KCNN3 are associated with higher negative symptom dimension scores in schizophrenia patients. There has been no attempt to replicate the results. In this study, we investigated whether a symptom polymorphism of schizophrenia is associated with both the CAG repeat numbers and the difference in allele sizes.


METHODS
We tested the association of CAG repeats with symptom models of schizophrenia in 117 unrelated Jewish patients. A multivariate analysis (MANOVA) of two models of schizophrenia with the repeat distribution and the difference in allele sizes was performed.


RESULTS
We found a significant positive association of the number of CAG repeats with negative syndrome, anergia, activation, and paranoid symptoms. In addition, nonparanoid schizophrenia patients who had differences in allele sizes were characterized by earlier onset of illness.


CONCLUSIONS
The study supports the hypothesis that the combined effect of long CAG repeats and the differences in allele sizes contribute to symptom expression of schizophrenia, particularly on the anergia-activation-paranoid axis.
Ritsner
Michael
M
Sha'ar Menashe Mental Health Center, Mobile Post Hefer 38814, Hadera, Israel.
Modai
Ilan
I
Ziv
Hana
H
Amir
Sharon
S
Halperin
Tami
T
Weizman
Abraham
A
Navon
Ruth
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D015139:Blotting, Southern; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015221:Potassium Channels / Q000235:genetics*; D024681:Potassium Channels, Calcium-Activated; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D012720:Severity of Illness Index; D051640:Small-Conductance Calcium-Activated Potassium Channels; D018911:Trinucleotide Repeats / Q000235:genetics*
D017931:DNA Primers; C406328:KCNN3 protein, human; D015221:Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D051640:Small-Conductance Calcium-Activated Potassium Channels