Clinical features and atopy profile in Turkish subjects with analgesic intolerance.
The factors underlying analgesic intolerance (AI), particularly the role of ethnic characteristics, are readily not clear. In this trial, we aimed to assess the predictive features of AI in Turkish subjects. One hundred and ninety patients with AI were enrolled into the study conducted in our tertiary care clinic. The types of drug causing adverse reaction(s) and types of reaction(s) were recorded. The presence of atopy was assessed by skin prick tests. According to the results, the most frequently intolerated analgesic was acetyl salicylic acid (72.1%), followed by nonsteroidal anti-inflammatory drugs (68.4%) and paracetamol (15.8%). Urticaria/angioedema (52.6%) and asthmatic response (40.5%) were the most common reactions to analgesics. Compared with the general adult population of Turkey, the rate of atopy was found be higher in patients with AI and asthma (25% vs. 45%, p = 0.004) but comparable in patients with AI but no atopic disorder (25% vs. 29.2%, p> 0.05). In conclusion, subjects exhibiting intolerance to analgesics have particular features in our population; the presence of atopy in these subjects seems to be associated with the coexistent asthma rather than the drug allergy itself.
Celik
Gülfem
G
Ankara University School of Medicine, Department of Chest Diseases, Division of Allergic Diseases, Turkey. fcelik@dialup.ankara.edu.tr
Mungan
Dilşad
D
Ozer
Faruk
F
Ediger
Dane
D
Bavbek
Sevim
S
Sin
Betül
B
Demirel
Yavuz S
YS
Misirligil
Zeynep
Z
D000082:Acetaminophen / Q000009:adverse effects / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000009:adverse effects* / Q000276:immunology*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000276:immunology; D000900:Anti-Bacterial Agents / Q000276:immunology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000276:immunology; D001241:Aspirin / Q000009:adverse effects / Q000276:immunology; D001249:Asthma / Q000209:etiology; D004342:Drug Hypersensitivity / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012882:Skin Tests; D014421:Turkey
D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D001241:Aspirin