Voltammetric investigation of beta-estradiol.
Electrooxidation of beta-estradiol was investigated using a glassy carbon electrode (GCE) by cyclic voltammetry (CV), and differential pulse voltammetry (DPV). The statistical analysis of the linear relationships between concentration and peak current permits the quantitation of beta-estradiol by both CV and DPV in the concentration range of 4 x 10(-5)-10(-3) M with enough precision and accuracy. A mechanism was proposed about the electrooxidation of this substance. The methods were applied to a tablet form and a transdermal therapeutic system (TTS) of this drug. The results were statistically compared with those of official high performance liquid chromatography (HPLC) method and the differences were found as insignificant.
Salci
Bülent
B
Ministry of Agriculture, P.K. 36 Yenimahalle 06 170, Ankara, Turkey.
Biryol
Inci
I
D000279:Administration, Cutaneous; D002021:Buffers; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D004566:Electrodes; D004958:Estradiol / Q000032:analysis* / Q000097:blood; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D012997:Solvents; D013607:Tablets
D002021:Buffers; D012997:Solvents; D013607:Tablets; D004958:Estradiol