High frequency jet ventilation is associated with increased levels of plasma alpha-atrial natriuretic peptide -- a preliminary study.
OBJECTIVE
To determine if high frequency jet ventilation (HFJV) influences the secretion of alpha-atrial natriuretic peptide (alpha- ANP).


METHODS
Sixteen patients undergoing otolaryngeal surgery were studied. Nine patients were subjected to intermittent positive pressure ventilation (IPPV), and seven patients underwent HFJV. Blood samples were drawn for the measurement of plasma alpha-ANP levels and blood gases before anesthesia, and at 30-min after starting either type of ventilation. The study was started at 2:00 p.m., and was completed before surgery. The plasma concentration of alpha-ANP was assayed by radioimmunoassay.


RESULTS
There were no significant differences in mean arterial pressure, heart rate, oxygenation index and PaCO(2) between the two groups. IPPV was not associated with any changes in plasma -ANP levels, whereas HFJV was associated with significantly increased plasma alpha-ANP levels (from 60.0 +/- 5.7 pg x mL(-1) before anesthesia to 112.0 +/- 11.6 pg x mL(-1) after ventilation, P < 0.01). The urine output of the HFJV patients was significantly greater than that of the IPPV patients (P < 0.05).


CONCLUSIONS
These preliminary results suggest that HFJV is associated with a significant increase in plasma ANP and in urine output in anesthetized patients.
Nagatani
Atsuko
A
Department of Anesthesiology, National Nagasaki Medical Center, Isahaya-Sogo Hospital, Oomura city, Nagasaki, Japan. tulipcat@nifty.com
Niiya
Sadayo
S
Sumikawa
Koji
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006611:High-Frequency Jet Ventilation / Q000009:adverse effects*; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013514:Surgical Procedures, Operative; D014554:Urination / Q000187:drug effects
D009320:Atrial Natriuretic Factor