title: Pulmonary hemangiomas of infancy and childhood: report of two cases and review of the literature.
abstract: Pulmonary hemangiomas are exceptionally rare in childhood and more so in infancy. They may involve the airways or the parenchyma, and may be localized or multifocal. We present two cases of pulmonary capillary hemangiomas. The first case is a localized form of capillary hemangioma that was resected from an 8-week-old infant with signs of respiratory distress. A computed tomography scan showed a cystic mass initially thought to be an intrapulmonary bronchogenic cyst. A segmental resection was performed and examination revealed a localized capillary hemangioma without cystic or cavernous features. The second case is an example of a multifocal capillary hemangioma from a 9-year-old child who presented clinically with clubbing of fingers and toes and radiologically had multiple discrete nodules localized to the right lung. The clinical and pathological features of the cases are discussed together with a review of the literature. The distinction from other vascular neoplasms of childhood is briefly described. Although rare, pulmonary hemangiomas should be entertained in the diagnosis of both solid and cystic intrapulmonary lesions of childhood and infancy.
authors: Department of Anatomic Pathology, Cleveland Clinic Foundation L-2 5, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors: Neil A
authors: NA
authors: Abrahams
authors: Thomas V
authors: TV
authors: Colby
authors: Richard H
authors: RH
authors: Pearl
authors: Bradley E
authors: BE
authors: Chipps
authors: Andrew L
authors: AL
authors: Juris
authors: Kevin O
authors: KO
authors: Leslie
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D005169:Factor VIII / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D018324:Hemangioma, Capillary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008297:Male; D009687:Nuclear Proteins / Q000032:analysis; D013902:Radiography, Thoracic; D012131:Respiratory Insufficiency / Q000209:etiology / Q000473:pathology; D000074482:Thyroid Nuclear Factor 1; D014057:Tomography, X-Ray Computed; D014157:Transcription Factors / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D005169:Factor VIII