title: An ortho-substituted BIPHEP ligand and its applications in Rh-catalyzed hydrogenation of cyclic enamides.
abstract: [reaction: see text] An ortho-substituted BIPHEP ligand, o-Ph-hexaMeO-BIPHEP (1), is designed and synthesized. Compared with chiral biaryl phosphines without ortho substituents such as BINAP and MeO-BIPHEP, o-Ph-hexaMeO-BIPHEP shows higher enantioselectivities in Rh-catalyzed hydrogenation of cyclic enamides.
authors: Department of Chemistry, The Pennsylvania State University, University Park 16802, USA.
authors: Wenjun
authors: W
authors: Tang
authors: Yongxiang
authors: Y
authors: Chi
authors: Xumu
authors: X
authors: Zhang
mesh_terms: D000577:Amides / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006865:Hydrogenation; D007202:Indicators and Reagents; D008024:Ligands; D008958:Models, Molecular; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C437189:2,2'-bis(diphenylphosphino)-1,1'-biphenyl; D000577:Amides; D001713:Biphenyl Compounds; D002219:Carbamates; D007202:Indicators and Reagents; D008024:Ligands; D012238:Rhodium