[Relationship between cholinesterase, prothrombin activity and albumin and the pathology of the liver].
BACKGROUND
To investigate the relationship between serum cholinesterase, albumin and plasma prothrombin activity and the pathology of the liver in patients with viral hepatitis.


METHODS
Totally 135 patients diagnosed as chronic hepatitis, cirrhosis and/or severe hepatitis with needle biopsy of liver were enrolled in this study. Serum cholinesterase and albumin of the patients were detected with enzyme rate method; meanwhile, their plasma prothrombin activity was detected with turbidimetry test.


RESULTS
The percentage of decrease of the level of serum cholinesterase was higher than that of albumin and plasma prothrombin activity in chronic mild and moderate hepatitis; the level of serum cholinesterase, albumin and plasma prothrombin activity decreased gradually followed by the exacerbation of inflammatory reaction (P<0.001) and by the elevation of degree of fibrosis of the liver (P <0.001) their correlation coefficient was 0.720 to 0.778 (P<0.001).


CONCLUSIONS
The level of serum cholinesterase could better a nd more sensitively reflect the synthetic function and the damage of the pathology of the liver than that of albumin and plasma prothrombin activity could do, they all negatively correlated with the pathology of the liver.
Zou
Z
Z
No. 302 Hospital of PLA, Beijing 100039, China.
Xin
S
S
Li
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002802:Cholinesterases / Q000097:blood*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000097:blood* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011516:Prothrombin / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*
D012709:Serum Albumin; D011516:Prothrombin; D002802:Cholinesterases