99mTc-diflunisal and the human iris: topical application reveals localization.
Following the instillation of a drug into the eye, drainage mechanisms will commence at once. In this report, an attempt was made to assess the dynamics of an instilled nonsteroidal anti-inflammatory drug (NSAID), diflunisal, labeled with 1 MBq 99mTc followed by twenty minutes of scintigraphy. The results obtained with this labeled drug were compared with instillation of the same volume and activity of 99mTcO4-. Although the pertechnetate anion is an excellent and innocuous indicator for detecting the external lacrimal drainage system of the eye, it cannot visualize the internal structures. A clear scintigraphic difference was noted between labeled diflunisal and the pertechnetate anion. Scintigraphic activity surrounding the pupil of the eye provides evidence of visualization of the iris/ciliary body. This seems reasonable as the cyclooxygenase enzyme is located in this structure, and NSAIDs exert their mechanism of action via this complex. With this technology, visualization of some internal structures of the eye may be facilitated.
van Sorge
Adriaan A
AA
Department of Pharmacy, Rijnstate Hospital, Arnhem, The Netherlands. avansorge@rijnstate.nl
van Etten
Robert Jan
RJ
Rehmann
Coen J
CJ
Rijnders
Ton J M
TJ
van Haeringen
Nicolaas J
NJ
D000287:Administration, Topical; D002851:Chromatography, High Pressure Liquid; D004061:Diflunisal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007498:Iris / Q000378:metabolism*; D011877:Radionuclide Imaging; D013056:Spectrophotometry, Ultraviolet; D013667:Technetium; D014018:Tissue Distribution
D013667:Technetium; D004061:Diflunisal