Increased levels of soluble CD30 in plasma of patients with Plasmodium falciparum malaria.
Levels of soluble CD30 (sCD30) in serum were elevated in patients with Plasmodium falciparum malaria but showed decline following treatment. The levels of sCD30 in serum were correlated significantly with the expression of gamma interferon by peripheral T cells. These data suggest that CD30(+) cells are upregulated during a malaria attack and that they may play a regulating role at the site of inflammation.
Kemp
Kåre
K
Center for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark. kkcmp@rh.dk
Kurtzhals
Jørgen A L
JA
Akanmori
Bartholomew D
BD
Adabayeri
Victoria
V
Goka
Bamenla Q
BQ
Behr
Charlotte
C
Hviid
Lars
L
D000818:Animals; D002478:Cells, Cultured; D002648:Child; D005869:Ghana; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D017730:Ki-1 Antigen / Q000097:blood*; D016778:Malaria, Falciparum / Q000097:blood / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology; D012995:Solubility; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
D017730:Ki-1 Antigen; D007371:Interferon-gamma