[Bioactive films for biomaterial coating and intended for tissue engineering: new original methods?].
Numerous functionalized biomaterials aimed to induce specific cellular or tissular responses have been developed in the last decade. They result often from a specific treatment of the interface of the material. Techniques like physisorption, covalent binding or deposition of a Langmuir-Blodgett film have been employed to modify surface properties. We describe here a novel approach based upon an alternated adsorption of polyelectrolytes (polyanions or polycations) leading to the build-up of a film. These films can be functionalized through protein insertion (ligands) or by covalent peptide bindings able to interact with cellular receptors. Combined with a high affinity for calcium or phosphate complexing properties such functionalized architectures could constitute an original way to favour osseointegration.
Schaaf
P
P
Institut Charles Sadron, ULP-CNRS UPR22, 6, rue Boussingault, 67083 Strasbourg, France.
Voegel
J C
JC
D000327:Adsorption; D020816:Amino Acid Motifs; D000818:Animals; D000838:Anions; D002412:Cations; D002448:Cell Adhesion; D020099:Coated Materials, Biocompatible; D003460:Crystallization; D017886:Durapatite / Q000737:chemistry; D004867:Equipment Design; D006801:Humans; D008422:Materials Testing; D016348:Osseointegration; D019736:Prostheses and Implants; D011485:Protein Binding; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
D000838:Anions; D002412:Cations; D020099:Coated Materials, Biocompatible; D017886:Durapatite