[Mechanisms of myocardial damage progression in heart failure].
Cardiac Failure is an increasing health problem in the world. Several mechanisms have been proposed as the cause of this epidemiological transition. The main reason is the increase in the survival of patients with coronary heart disease and the improvement in the management of cardiac failure with new drugs. Knowledge of new mechanisms including gene regulation, extracelullar matrix function, intracardiac vessels, neuroendocrine interrelations, inflammatory activity, immune balance, signalling intracellular and extracellular cascade, and mechanical integrity, have permitted a better and rational approach. The influence of paradigms such as endothelin system, sympathovagal balance, oxidative system, angiotensin receptors, aldosterone receptors have been demonstrated on progression of the cellular damage's patients with cardiac failure. Apoptosis is recognized as a common final way. In this review all these topics are analyzed. Emphasis is made on the new therapeutics strategies of treatment.
Rosas Peralta
Martín
M
Instituto Nacional de Cardiología, Ignacio Chávez, INCICH, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, 14080 México, D. F. martinrp02@yahoo.com.mx
D000208:Acute Disease; D009202:Cardiomyopathies / Q000209:etiology*; D002908:Chronic Disease; D018450:Disease Progression; D006333:Heart Failure / Q000150:complications*; D006801:Humans