Study of the paraoxonase and platelet-activating factor acetylhydrolase activities with aging.
The purpose of this study was to investigate, with aging, the activity of two enzymes associated to HDL and responsible for its anti-atherogenic activity; paraoxonase (PON1) and platelet-activating factor acetylhydrolase (PAF-AH). Ninety-five subjects aged between 26 and 77 years were recruited for the study. The prevalence of phenotype A, AB, and B in our subjects group was 69.47,21.05 and 9.47% respectively. Plasma as well as HDL paraoxonase activity decreased significantly with aging (r =-0.218, P < 0.039) and (r = -0.280, P < 0.006) respectively. PAF-AH activity was unchanged with aging however, we noted a negative correlation between PAF-AH and PON1 activity in HDL (r = -0.243, P < 0.02) and in LDL vs HDL (r =-0.462, P < 0.001).
Milochevitch
C
C
Centre de recherche, Institut Universitaire de Gériatrie de Sherbrooke, Université de Sherbrooke, QC, Canada.
Khalil
A
A
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D043303:Aryldialkylphosphatase; D004950:Esterases / Q000097:blood* / Q000235:genetics; D005260:Female; D006720:Homozygote; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood*; D012907:Smoking; D044465:White People
D008075:Lipoproteins, HDL; D004950:Esterases; D010741:Phospholipases A; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human