title: C-reactive protein levels are influenced by common IL-1 gene variations.
abstract: Elevated markers of systemic inflammation are associated with the development of acute coronary syndromes, but there is no current explanation for increased inflammation in overtly healthy individuals. The influence of genetic control of the inflammatory response on the observed variability is unknown. We studied the frequency of four polymorphisms in interleukin (IL) 1 genes, known to modulate inflammation, in 454 individuals undergoing coronary angiography and analysed their influence on plasma C-reactive protein (CRP) and fibrinogen levels. Females and smokers had higher levels of CRP than males (Pi = 0.001) and non-smokers (Pi = 0.001). Patients with genotype 2.2 for the IL-1B(+3954) polymorphism had twice the median CRP levels of patients who were genotype 1.1 (4.33 vs 2.01 mg/l; P = 0.001). Patients with genotype 1.2 or 2.2 at the IL-1A(+4845) polymorphism also had higher median CRP (2.92 vs 2.05 mg/l, Pi = 0.023). In multivariate analyses, CRP levels remained significantly associated with IL-1 polymorphisms after adjustment for smoking, gender and age. Fibrinogen levels had similar associations with the IL-1 genotypes. These data indicate that IL-1 gene polymorphisms known to affect the inflammatory response are highly related to plasma levels of CRP and fibrinogen in patients referred for coronary angiography.
authors: Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota 55905, USA . berger.peter@mayo.edu
authors: Peter
authors: P
authors: Berger
authors: Joseph P
authors: JP
authors: McConnell
authors: Martha
authors: M
authors: Nunn
authors: Kenneth S
authors: KS
authors: Kornman
authors: Julian
authors: J
authors: Sorrell
authors: Katherine
authors: K
authors: Stephenson
authors: Gordon W
authors: GW
authors: Duff
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D014644:Genetic Variation; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012907:Smoking / Q000009:adverse effects
chemical_list: D007375:Interleukin-1; D005340:Fibrinogen; D002097:C-Reactive Protein