title: A novel water-soluble Hantzsch 1,4-dihydropyridine compound that functions in biological processes through NADH regeneration.
abstract: A novel Hantzsch 1,4-dihydropyridine derivative could function in an organic solvent-free solution, and thus it could function in biological systems. These functions can be accomplished through regeneration of the reduced form of nicotinamine adenine dinucleotide (NADH), an essential compound for living organisms. The results obtained here demonstrate the usefulness of a water-soluble Hantzsch 1,4-dihydropyridine derivative and its wide applicability as a chemical energy source, which drives various biological processes efficiently.
authors: Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan. ueda@sanken.osaka-u.ac.jp
authors: Yoshihiro
authors: Y
authors: Sambongi
authors: Hajime
authors: H
authors: Nitta
authors: Kayoko
authors: K
authors: Ichihashi
authors: Masamitsu
authors: M
authors: Futai
authors: Ikuo
authors: I
authors: Ueda
mesh_terms: D002625:Chemistry, Organic / Q000379:methods; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D004926:Escherichia coli / Q000378:metabolism; D008566:Membranes / Q000187:drug effects; D015394:Molecular Structure; D009243:NAD / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: C466879:2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester; D004095:Dihydropyridines; D009243:NAD; C038806:1,4-dihydropyridine