Evolutionary principles for generating protein mimetics: directed assembly of peptide loops on topological templates.
A novel methodology for the reversible competitive condensation of peptide loops to chemoreactive topological templates is presented.
Banfi
D
D
Institute of Organic Chemistry, University of Lausanne, Switzerland.
Mandal
B
B
Mutter
M
M
Patiny
L
L
D001667:Binding, Competitive; D001671:Biochemistry / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D008024:Ligands; D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry*; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*
D008024:Ligands; D010455:Peptides; D011506:Proteins