Serotonin and vasopressin interact in the hypothalamus to control communicative behavior.
The present study investigated whether serotonin (5-HT) agonists could inhibit the ability of arginine-vasopressin (AVP) to induce a form of scent marking called flank marking by their actions in the medial preoptic-anterior hypothalamus (MPOA-AH). DOI, a 5-HT2A,2B,2C receptor agonist, did not inhibit AVP-induced flank marking, but mCPP a 5-HT2A antagonist and 5-HT2B,2C agonist inhibited AVP-induced flank marking. In addition, the finding that 8-OH-DPAT, CGS-12066A and SC53116 also inhibited AVP-induced flank marking suggests that 5-HT could also inhibit flank marking by acting through 5-HT1A, 5-HT7, 5-HT1B and/or 5-HT4 receptor subtypes. These data support the hypothesis that 5-HT acts within the MPOA-AH to inhibit the ability of AVP to induce flank marking.
Albers
H Elliott
HE
Center for Behavioral Neuroscience, Departments of Biology and Psychology, Georgia State University, Atlanta, GA 30303, USA.
Karom
Mary
M
Smith
Debra
D
D000819:Animal Communication; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D006224:Cricetinae; D007031:Hypothalamus / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D008647:Mesocricetus; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D014662:Vasoconstrictor Agents; D001127:Arginine Vasopressin; D012701:Serotonin