Disseminated toxoplasmosis, resulting from infection of allograft, after orthotopic liver transplantation: usefulness of quantitative PCR.
Disseminated toxoplasmosis is a life-threatening disease in liver transplant recipients that can result from an organ-transmitted infection. We report here a case of fatal disseminated toxoplasmosis after orthotopic liver transplantation from a seropositive donor (immunoglobulin G [IgG](+) and IgM(-)) in a patient who was nonimmune for toxoplasmosis prior to transplantation. Quantitative PCR analyses of various clinical specimens, including serum samples, appeared retrospectively to be a valuable diagnostic tool that might guide therapeutic attitudes.
Botterel
Francoise
F
Service de Microbiologie, Departement de Parasitologie-Mycologie, Hopital de Bicetre, Faculté de Médecine Paris-Sud, 78 rue du Général Leclerc, 94275 Kremlin-Bicetre Cedex, France. francoise.botterel@bct.ap-hop.paris.fr
Ichai
P
P
Feray
C
C
Bouree
P
P
Saliba
F
F
Tur Raspa
R
R
Samuel
D
D
Romand
S
S
D000328:Adult; D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D016133:Polymerase Chain Reaction / Q000379:methods; D011183:Postoperative Complications / Q000469:parasitology*; D014122:Toxoplasma / Q000302:isolation & purification*; D014123:Toxoplasmosis / Q000175:diagnosis*; D014184:Transplantation, Homologous
D017931:DNA Primers