Diarrhea-inducing activity of avian rotavirus NSP4 glycoproteins, which differ greatly from mammalian rotavirus NSP4 glycoproteins in deduced amino acid sequence in suckling mice.
Avian rotavirus NSP4 glycoproteins expressed in Escherichia coli acted as enterotoxins in suckling mice, as did mammalian rotavirus NSP4 glycoproteins, despite great differences in the amino acid sequences. The enterotoxin domain of PO-13 NSP4 exists in amino acid residues 109 to 135, a region similar to that reported in SA11 NSP4.
Mori
Yoshio
Y
Department of Veterinary Public Health, Faculty of Agriculture, Gifu University, Gifu 501-1193, Japan.
Borgan
Mohammed Ali
MA
Ito
Naoto
N
Sugiyama
Makoto
M
Minamoto
Nobuyuki
N
D000596:Amino Acids; D000818:Animals; D001665:Binding Sites; D001715:Bird Diseases / Q000821:virology; D002460:Cell Line; D002645:Chickens / Q000821:virology; D010856:Columbidae / Q000821:virology; D003967:Diarrhea / Q000821:virology*; D004768:Enterotoxins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D008253:Macaca mulatta; D051379:Mice; D008807:Mice, Inbred BALB C; D030101:Orthoreovirus, Avian / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology; D012088:Reoviridae Infections / Q000662:veterinary / Q000821:virology; D014118:Toxins, Biological; D014422:Turkeys / Q000821:virology; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology
D000596:Amino Acids; D004768:Enterotoxins; D006023:Glycoproteins; C081369:NS28 protein, rotavirus; D011993:Recombinant Fusion Proteins; D014118:Toxins, Biological; D017361:Viral Nonstructural Proteins