title: Highly chemoselective rhodium-catalyzed methylenation of fluorine-containing ketones.
abstract: [reaction: see text] The rhodium(I)-catalyzed methylenation of functionalized fluorinated ketones using trimethylsilyldiazomethane proceeds to give the corresponding fluoromethylalkenes in good yields (61-90%). Remarkable chemoselectivity was observed for the synthesis of keto-substituted organofluorine alkenes.
authors: Département de Chimie, Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, Québec, Canada H3C 3J7. lebelhe@chimie.umontreal.ca
authors: Hélène
authors: H
authors: Lebel
authors: Valérie
authors: V
authors: Paquet
mesh_terms: D000475:Alkenes; D002384:Catalysis; D002849:Chromatography, Gas; D005461:Fluorine / Q000737:chemistry*; D007202:Indicators and Reagents; D007659:Ketones / Q000138:chemical synthesis*; D008745:Methylation; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D007202:Indicators and Reagents; D007659:Ketones; D005461:Fluorine; D012238:Rhodium