title: Effect of clarithromycin on chronic respiratory infection caused by Pseudomonas aeruginosa with biofilm formation in an experimental murine model.
abstract: Fourteen-membered macrolides (e.g. clarithromycin and erythromycin), but not 16-membered macrolides (e.g. josamycin), are effective in diffuse panbronchiolitis. However, there are no studies that have compared the effects of 14- and 16-membered macrolide antibiotics on biofilm formation. Treatment with high-dose clarithromycin (100 mg/kg) resulted in a significant decrease in the number of viable bacteria in an experimental murine model. Josamycin at a dose of up to 100 mg/kg had no effect on the number of viable bacteria in the lung. Our results may explain, at least in part, the clinical efficacy of 14-membered macrolide antibiotics in patients with chronic pneumonia caused by Pseudomonas aeruginosa.
authors: The Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852, Japan. kyana-ngs@umin.ac.jp
authors: Katsunori
authors: K
authors: Yanagihara
authors: Kazunori
authors: K
authors: Tomono
authors: Yoshifumi
authors: Y
authors: Imamura
authors: Yukihiro
authors: Y
authors: Kaneko
authors: Misuzu
authors: M
authors: Kuroki
authors: Toyomitsu
authors: T
authors: Sawai
authors: Yoshitsugu
authors: Y
authors: Miyazaki
authors: Yoichi
authors: Y
authors: Hirakata
authors: Hiroshi
authors: H
authors: Mukae
authors: Jun-Ichi
authors: J
authors: Kadota
authors: Shigeru
authors: S
authors: Kohno
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D018441:Biofilms / Q000187:drug effects*; D002908:Chronic Disease; D017291:Clarithromycin / Q000627:therapeutic use*; D015570:Josamycin / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology*; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin; D015570:Josamycin