title: Pulmonary hemodynamics and gas exchange after liver transplantation in patients with cirrhosis.
abstract: In patients with cirrhosis, discrepant findings have been reported on the evolution of pulmonary hemodynamics and gas exchange after liver transplantation. The aim of this study was to evaluate the effects of liver transplantation on pulmonary and systemic hemodynamics and gas exchange in patients transplanted for cirrhosis. Forty-three patients with cirrhosis underwent hemodynamic investigations before and one year after liver transplantation. Mean pulmonary arterial pressures did not significantly change after transplantation (from 17 +/- 4 to 17 +/- 3 mm Hg) whereas pulmonary vascular resistance significantly increased by 62%. Cardiac index significantly decreased by 20%. PaO2 did not change significantly after transplantation (from 88.8 +/- 13.9 to 88.5 +/- 12.1 mm Hg) and PaCO2 significantly increased by 16%. In conclusion, liver transplantation has no effect on pulmonary pressures but normalizes pulmonary vascular resistance in patients with cirrhosis without pulmonary hypertension. Moreover, it has no major effect on gas exchange in patients with cirrhosis without hypoxemia.
authors: Laboratoire d'Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U-481, Hôpital Beaujon, Clichy, France.
authors: Emmanuel
authors: E
authors: Rassiat
authors: Eric
authors: E
authors: Barrière
authors: Francois
authors: F
authors: Durand
authors: Jacques
authors: J
authors: Bernuau
authors: Jacques
authors: J
authors: Belghiti
authors: Dominique
authors: D
authors: Valla
authors: Richard
authors: R
authors: Moreau
authors: Didier
authors: D
authors: Lebrec
mesh_terms: D005260:Female; D006439:Hemodynamics; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology* / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D011184:Postoperative Period; D011652:Pulmonary Circulation; D011659:Pulmonary Gas Exchange; D014655:Vascular Resistance