Spermatogonial stem cell preservation and transplantation.
Spermatogonia are the male germ line stem cells. Their life long expansion is needed for permanent production of male germ cells. Spermatogonia are the only cells of the germ line, which proliferate in adulthood and offer interesting applications as they are potentially totipotent and immortal cells. This review presents some of the recent breakthroughs, which have led to a better understanding of spermatogonial physiology and opened new fields of basic research and of clinical applications in veterinary and medical science.
Schlatt
Stefan
S
Center for Animal Transgenesis and Germ Cell Research, University of Pennsylvania, 382 West Street Rd, Kennett Square, PA 19348, USA. schlatt@vet.upenn.edu
D000818:Animals; D018929:Cell Culture Techniques; D015925:Cryopreservation; D006801:Humans; D008297:Male; D013093:Spermatogonia / Q000166:cytology / Q000637:transplantation*; D039901:Totipotent Stem Cells / Q000166:cytology / Q000637:transplantation