Serum leptin levels in patients with polycystic ovary syndrome.
OBJECTIVE
To determine whether polycystic ovary syndrome (PCOS) is related to leptin dysregulation.


METHODS
Prospective study.


METHODS
Department of Obstetrics and Gynecology in a university hospital.


METHODS
Fifty patients with PCOS (33 nonobese and 17 obese) and 32 control women (19 nonobese and 13 obese) were included in the study.


METHODS
Serum leptin levels were measured in patients with PCOS and the controls. Correlations between leptin levels and serum hormone levels (FSH, LH, free testosterone, androstenedione, DHEA-S and fasting insulin) were studied.


METHODS
Serum leptin levels and correlations between leptin levels and the hormonal parameters.


RESULTS
Mean serum leptin levels were not significantly higher in patients with PCOS compared to the control group. Leptin levels were found to be significantly higher in the obese subgroups both in patients with PCOS and in the control women. Leptin levels were found to be higher in obese patients with PCOS compared to obese controls; however, when the levels were evaluated again with covariance analysis excluding body mass index, there was no statistically significant difference. Leptin levels had a positive correlation with body mass index, both in patients with PCOS and the controls.


CONCLUSIONS
Leptin levels were not higher in patients with PCOS compared to the control group; the leptin level was correlated with the amount of fat tissue not only in patients with PCOS but also in healthy women.
Telli
Muhittin H
MH
Department of Obstetrics and Gynecology, Gazi University School of Medicine, Besevler, Ankara, Turkey.
Yildirim
Mulazim
M
Noyan
Volkan
V
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D009765:Obesity / Q000097:blood / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000473:pathology; D011446:Prospective Studies
D020738:Leptin