Searching for the middle ground: mechanisms of chromosome alignment during mitosis.
The contributions of key molecules predicted to align chromosomes at the center of the mitotic spindle have been recently examined. New results dictate that models for how chromosomes align during the early stages of mitosis must be revised to integrate properties of microtubule-based motor proteins as well as microtubule dynamics.
Kapoor
Tarun M
TM
Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10021, USA. Kapoor@rockefeller.edu
Compton
Duane A
DA
D000818:Animals; D001696:Biomechanical Phenomena; D023902:Chromosome Pairing / Q000235:genetics*; D006801:Humans; D018386:Kinetochores / Q000502:physiology*; D008870:Microtubules / Q000235:genetics*; D008938:Mitosis / Q000235:genetics*; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000235:genetics*; D008941:Spindle Apparatus / Q000235:genetics*
D020409:Molecular Motor Proteins