title: Isolation and identification of a new bifidogenic growth stimulator produced by Propionibacterium freudenreichii ET-3.
abstract: We have found a new growth stimulator for bifidobacteria in the culture broth of Propionibacterium freudenreichii ET-3. The bifidogenic growth stimulator (BGS) was purified by Diaion HP-20 column chromatography and preparative HPLC. Spectroscopic methods including 1H-NMR, UV, and LC-ESI-MS experiments indicated that the chemical structure of the bifidogenic growth stimulator was 1,4-dihydroxy-2-naphthoic acid (DHNA). Approximately 10 mg/L of DHNA was found to be produced in the culture broth of P. freudenreichii ET-3.
authors: Research & Development Center, Meiji Dairies Corporation, Kanagawa, Japan.
authors: Kakuhei
authors: K
authors: Isawa
authors: Kenichi
authors: K
authors: Hojo
authors: Nobuo
authors: N
authors: Yoda
authors: Tomonori
authors: T
authors: Kamiyama
authors: Seiya
authors: S
authors: Makino
authors: Mizue
authors: M
authors: Saito
authors: Hitomi
authors: H
authors: Sugano
authors: Chinami
authors: C
authors: Mizoguchi
authors: Saori
authors: S
authors: Kurama
authors: Mika
authors: M
authors: Shibasaki
authors: Noriko
authors: N
authors: Endo
authors: Yoshio
authors: Y
authors: Sato
mesh_terms: D001644:Bifidobacterium / Q000187:drug effects* / Q000254:growth & development*; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D009284:Naphthols / Q000378:metabolism* / Q000494:pharmacology*; D011424:Propionibacterium / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D009284:Naphthols; C024023:1,4-dihydroxy-2-naphthoic acid