Analysis of subtraction methods in three-dimensional contrast-enhanced peripheral MR angiography.
OBJECTIVE
To compare the effectiveness of three image subtraction algorithms designed to improve arterial conspicuity in first-pass contrast-enhanced magnetic resonance (MR) angiography.


METHODS
Three subtraction methods were analyzed through computer simulations, phantom studies, and clinical studies. These algorithms were: complex subtraction, magnitude subtraction, and maximum intensity projection subtraction.


RESULTS
In high resolution three-dimensional imaging, maximum intensity projection subtraction generally yields the best background suppression. Complex subtraction is effective in reducing partial volume effects in low resolution imaging. Magnitude subtraction works better in high resolution, low contrast concentration protocols.


CONCLUSIONS
Choosing the appropriate subtraction method according to the protocol is helpful in optimizing image quality.
Huang
Yuexi
Y
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. huangyx@sten.sunnybrook.utoronto.ca
Webster
Christie A
CA
Wright
Graham A
GA
D000465:Algorithms; D015901:Angiography, Digital Subtraction / Q000379:methods*; D003198:Computer Simulation; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D016491:Peripheral Vascular Diseases / Q000175:diagnosis*; D019047:Phantoms, Imaging
D003287:Contrast Media; D019786:Gadolinium DTPA