Efficacy of vitamin-C (L-ascorbic acid) in reducing genotoxicity in fish (Oreochromis mossambicus) induced by ethyl methane sulphonate.
The genotoxic effects of ethyl methane sulphonate (EMS) have been assessed in a fish, Oreochromis mossambicus with endpoints including chromosome aberrations, abnormal red blood cell nuclei, abnormal sperm morphology, and protein content (both qualitative and quantitative) of selected tissues, namely, muscle, heart, eye, brain, gill, liver, spleen and kidney. EMS caused chromosomal aberrations, nuclear anomalies in red blood cells, abnormal sperm morphology, and alteration of protein synthesis in various tissues. Some of the EMS toxicity appeared to be modulated and ameliorated in this fish by vitamin-C treatment.
Guha
B
B
Department of Zoology, Kalyani University, India.
Khuda-Bukhsh
A R
AR
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002869:Chromosome Aberrations / Q000139:chemically induced*; D004347:Drug Interactions; D005020:Ethyl Methanesulfonate / Q000009:adverse effects*; D008297:Male; D015162:Micronucleus Tests; D009153:Mutagens / Q000009:adverse effects*; D014176:Protein Biosynthesis; D013094:Spermatozoa / Q000002:abnormalities; D017210:Tilapia / Q000235:genetics* / Q000502:physiology*; D014018:Tissue Distribution
D009153:Mutagens; D005020:Ethyl Methanesulfonate; D001205:Ascorbic Acid