title: Expression of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain.
abstract: The tricarboxylate carrier protein catalyzes an electroneutral exchange across the mitochondrial inner membrane of tricarboxylate, dicarboxylate or phosphoenolpyruvate. We examined expression and localization of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain. TCC mRNA was ubiquitously expressed in all rat tissues examined and was abundant in brain, liver and kidney. TCC protein as well as mRNA was widely expressed in brain, and the protein expression was strong in neuronal cells in the hippocampus, the olfactory bulb, the corpus mamillare and the cerebellum. Our results suggest that this tricarboxylate carrier protein may contribute to biosynthesis and bioenergetics in neuronal cells in brain.
authors: Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors: Shin-ichi
authors: S
authors: Miyake
authors: Toshihide
authors: T
authors: Yamashita
authors: Manabu
authors: M
authors: Taniguchi
authors: Michio
authors: M
authors: Tamatani
authors: Kohji
authors: K
authors: Sato
authors: Yoshikuni
authors: Y
authors: Kawai
authors: Emiko
authors: E
authors: Senba
authors: Noriaki
authors: N
authors: Mitsuda
authors: Osamu
authors: O
authors: Hori
authors: Atsushi
authors: A
authors: Yamaguchi
authors: Masaya
authors: M
authors: Tohyama
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002952:Citric Acid Cycle / Q000235:genetics; D004734:Energy Metabolism / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D007150:Immunohistochemistry; D007425:Intracellular Membranes / Q000378:metabolism*; D007668:Kidney / Q000166:cytology / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000166:cytology / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D012333:RNA, Messenger; C020723:citrate-binding transport protein