title: Neurotensin-induced modulation of dopamine D2 receptors and their function in rat striatum: counteraction by a NTR1-like receptor antagonist.
abstract: The present study investigated the neurotensin (NT) receptor subtype (NTR) involved in the antagonistic neurotensin modulation of striatal dopamine D2 receptors observed in vitro and in vivo. The NT induced increase of the IC50 values of dopamine (DA) competition for [125I]iodosulpiride binding sites was counteracted by the NTR1-like antagonist SR48692 in rat striatal slices. Intrastriatal perfusion of pergolide induced in the awake rat an inhibition of striatal DA release that was antagonized by NT. This action of NT was counteracted by co-perfusion with the NTR1 like antagonist SR48692. These data indicate that there exists in the striatum at the prejunctional level an intramembrane antagonistic NT receptor/DA D2 receptor-receptor interaction where NTR1 like receptor activation reduces the DA D2 autoreceptor function.
authors: Department of Neuroscience, Karolinska Institute, S 171-77 Stockholm, Sweden.
authors: Zaida
authors: Z
authors: Díaz-Cabiale
authors: Kjell
authors: K
authors: Fuxe
authors: Jose Angel
authors: JA
authors: Narváez
authors: Simone
authors: S
authors: Finetti
authors: Tiziana
authors: T
authors: Antonelli
authors: Sergio
authors: S
authors: Tanganelli
authors: Luca
authors: L
authors: Ferraro
mesh_terms: D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects / Q000502:physiology; D004298:Dopamine / Q000378:metabolism*; D018491:Dopamine Agonists / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D004347:Drug Interactions / Q000502:physiology; D008297:Male; D017072:Neostriatum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009496:Neurotensin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010479:Pergolide / Q000494:pharmacology; D011720:Pyrazoles; D011804:Quinolines; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D018028:Receptors, Neurotensin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013469:Sulpiride / Q000031:analogs & derivatives*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*
chemical_list: D018491:Dopamine Agonists; D065127:Dopamine D2 Receptor Antagonists; D011720:Pyrazoles; D011804:Quinolines; D017448:Receptors, Dopamine D2; D018028:Receptors, Neurotensin; C045105:iodosulpride; C079087:SR 48692; D010479:Pergolide; D009496:Neurotensin; D013469:Sulpiride; D004298:Dopamine