TSH secretory pattern and thyroid function in children with growth hormone neurosecretory dysfunction.
We evaluated the TSH secretory pattern and free T4 in 10 prepubertal children with short stature, normal response to GH provocative tests, and reduced GH integrated concentration (IC-GH) (GH neurosecretory dysfunction). Although their nadir TSH, peak TSH, TSH surge, and free T4 were lower than those of 12 children with short stature and normal IC-GH, none of the differences reached statistical significance. Thus, our results suggest that children with low IC-GH (GH neurosecretory dysfunction) exhibit a TSH secretory pattern and thyroid function similar to those with normal IC-GH.
Quevedo
M F F W
MF
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA.
Pironis
B
B
Palese
T
T
Counts
D R
DR
De Luca
F
F
D001846:Bone Development; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D019382:Human Growth Hormone / Q000172:deficiency* / Q000378:metabolism; D006801:Humans; D008297:Male; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood
D019382:Human Growth Hormone; D013972:Thyrotropin; D013974:Thyroxine