Diversity of rotavirus strains among children with acute diarrhea in China: 1998-2000 surveillance study.
As part of a national rotavirus surveillance activity, we collected fecal specimens from 3,177 children with acute diarrhea in 10 regions of China between April 1998 and April 2000 and screened them for rotavirus. Rotavirus was detected in 41% (n = 1,305) of specimens, and in these, G1 was the predominant serotype (72.6%), followed by G3 (14.2%), G2 (12.1%), G4 (2.5%), G9 (0.9%), and G untypeable (0.7%). Among 327 G-typed strains tested for P genotype, 14 different P-G combinations were identified, with the globally common strains P[8]G1, P[4]G2, P[8]G3, and P[8]G4 representing 75.6% of all typed rotavirus strains. Among the uncommon strains, 11 were P[6]G9, and others included P[6]G1, P[6]G3, and five novel P-G combinations (P[9]G1, P[4]G1, P[4]G3, P[4]G4, and P[8]G2). Our results indicate that while the common rotavirus strains remain predominant, the diversity of strains is much greater than was previously recognized.
Fang
Zhao-Yin
ZY
Division of Enteric Viruses, Institute of Virology, Chinese Academy of Preventive Medicine, 100 Ying Xin Jie, Xuan Wu Qu, Beijing 100052, People's Republic of China. fangzhyn@263.net
Yang
Hui
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Qi
Jin
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Zhang
Jing
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Sun
Li-Wei
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Tang
Jing-Yu
JY
Ma
Li
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Du
Zeng-Qing
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He
Ai-Hua
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Xie
Jian-Ping
JP
Lu
Yi-Yu
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Ji
Zhen-Zhou
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Zhu
Bao-Quan
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Wu
Hai-Yan
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Lin
Si-En
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Xie
Hua-Ping
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Griffin
Dixie D
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Ivanoff
Bernard
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Glass
Roger I
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Gentsch
Jon R
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D000208:Acute Disease; D002648:Child; D002681:China / Q000453:epidemiology; D003967:Diarrhea / Q000453:epidemiology* / Q000821:virology; D005838:Genotype; D005843:Geography; D006801:Humans; D015994:Incidence; D011159:Population Surveillance; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012401:Rotavirus / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000453:epidemiology*