title: [Efficacy and safety of high doses of beclomethasone dipropionate in patients with bronchial asthma].
abstract: OBJECTIVE
  To assess efficiency and safety of high-dose beklometasone dipropionate in patients with bronchial asthma (BA).
  
  
  METHODS
  The trial included 14 female and 3 male patients with moderate or severe BA (mean age 43.6 years) in declining exacerbation. The patients inhaled beklometasone dipropionate as a dose-adjusted aerosol with built-up spacer (beklojet) in a daily dose 1000-2000 mcg for 8 weeks. Changes in clinical symptoms, life quality (AQLQ) and bronchial permeability (peak flowmetry, FEV1) were registered. Concentration of H2O2 in expired air condensate was measured spectrophotometrically to evaluate activity of airway inflammation. Oral smears were studied mycologically, hydrocortisone in blood plasma was measured with enzyme immunoassay.
  
  
  RESULTS
  The treatment produced positive trend in clinical symptoms and quality of life. Bronchial permeability improved since the 7th treatment day. H2O2 significantly fell, hydrocortisone levels and fungal flora did not change significantly.
  
  
  CONCLUSIONS
  Beklometasone dipropionate in high doses for 8 weeks is effective and safe against BA.
authors: A V
authors: AV
authors: Emel'ianov
authors: T E
authors: TE
authors: Trendeleva
authors: O I
authors: OI
authors: Krasnoshchekova
authors: S A
authors: SA
authors: Shubin
authors: N S
authors: NS
authors: Katysheva
mesh_terms: D000328:Adult; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000523:psychology; D001507:Beclomethasone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006861:Hydrogen Peroxide / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011788:Quality of Life
chemical_list: D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D006861:Hydrogen Peroxide; D001507:Beclomethasone; D006854:Hydrocortisone