Direct catalytic asymmetric alpha-amination of aldehydes.
The first direct catalytic asymmetric alpha-amination of aldehydes is described herein. alpha-Unbranched aldehydes react in this novel proline-catalyzed reaction with dialkyl azodicarboxylates to give alpha-amino aldehydes in excellent yields and enantioselectivities.
List
Benjamin
B
The Scripps Research Institute, Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. blist@scripps.edu
D000447:Aldehydes / Q000737:chemistry*; D000586:Amination; D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D023303:Oxazolidinones / Q000138:chemical synthesis; D011392:Proline / Q000737:chemistry; D013237:Stereoisomerism
D000447:Aldehydes; D000588:Amines; D023303:Oxazolidinones; D011392:Proline