title: Emerging concepts of nucleolar assembly.
abstract: The nucleolus is a large nuclear domain and the site of ribosome biogenesis. It is also at the parting of the ways of several cellular processes, including cell cycle progression, gene silencing, and ribonucleoprotein complex formation. Consequently, a functional nucleolus is crucial for cell survival. Recent investigations of nucleolar assembly during the cell cycle and during embryogenesis have provided an integrated view of the dynamics of this process. Moreover, they have generated new ideas about cell cycle control of nucleolar assembly, the dynamics of the delivery of the RNA processing machinery, the formation of prenucleolar bodies, the role of precursor ribosomal RNAs in stabilizing the nucleolar machinery and the fact that nucleolar assembly is completed by cooperative interactions between chromosome territories. This has opened a new area of research into the dynamics of nuclear organization and the integration of nuclear functions.
authors: CNRS, Université Paris VI, Université Paris VII, Institut Jacques Monod, 2 place Jussieu, 75251 Paris Cedex 05, France. dhernand@ccr.jussieu.fr
authors: Danièle
authors: D
authors: Hernandez-Verdun
authors: Pascal
authors: P
authors: Roussel
authors: Jeannine
authors: J
authors: Gébrane-Younès
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D002466:Cell Nucleolus / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D004256:DNA Polymerase I / Q000378:metabolism; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D012335:RNA, Ribosomal / Q000096:biosynthesis* / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D012335:RNA, Ribosomal; D018844:Cyclin-Dependent Kinases; D004256:DNA Polymerase I