title: Safety, tolerability, and efficacy of orally administered cannabinoids in MS.
abstract: The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse events were more common with plant-extract treatment. Compared with placebo, neither THC nor plant-extract treatment reduced spasticity. Both THC and plant-extract treatment worsened the participant's global impression.
authors: Department of Neurology, VU Medical Center, Amsterdam, the Netherlands. J.Killestein@vumc.nl
authors: J
authors: J
authors: Killestein
authors: E L J
authors: EL
authors: Hoogervorst
authors: M
authors: M
authors: Reif
authors: N F
authors: NF
authors: Kalkers
authors: A C
authors: AC
authors: Van Loenen
authors: P G M
authors: PG
authors: Staats
authors: R W
authors: RW
authors: Gorter
authors: B M J
authors: BM
authors: Uitdehaag
authors: C H
authors: CH
authors: Polman
mesh_terms: D000284:Administration, Oral; D002186:Cannabinoids / Q000008:administration & dosage* / Q000009:adverse effects; D002188:Cannabis; D018592:Cross-Over Studies; D004311:Double-Blind Method; D013759:Dronabinol / Q000008:administration & dosage; D006304:Health Status; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy*; D009128:Muscle Spasticity / Q000188:drug therapy / Q000209:etiology; D009129:Muscle Tonus / Q000187:drug effects; D010147:Pain Measurement; D010936:Plant Extracts / Q000008:administration & dosage; D018401:Sample Size; D016896:Treatment Outcome
chemical_list: D002186:Cannabinoids; D010936:Plant Extracts; D013759:Dronabinol