The management of croup.
Croup is a common paediatric respiratory illness involving inflammation and narrowing of the subglottic region of the larynx, frequently precipitated by viral infections. Treatment is aimed at decreasing symptoms and reducing inflammation. Glucocorticoids are effective by oral, parenteral or nebulized routes, and continue to provide the mainstay of therapy. The common oral dexamethasone dose (0.6 mg/kg) may exceed the dose required for good clinical efficacy. Nebulized epinephrine provides effective additional therapy for more severe cases. L-epinephrine appears to be comparable to racemic epinephrine, although further study is warranted. Limited data suggest that heliox is also effective in the short-term management of refractory croup. The use of humidified oxygen remains controversial, as good data are lacking.
Brown
Julie C
JC
Division of General Academic Pediatrics, Department of Pediatrics, University of Washington School of Medicine, and Children's Hospital and Regional Medical Center, Seattle, Washington 98105-0371, USA.
D001993:Bronchodilator Agents / Q000627:therapeutic use; D002675:Child, Preschool; D003440:Croup / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D003907:Dexamethasone / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004837:Epinephrine / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006371:Helium / Q000008:administration & dosage; D006801:Humans; D006813:Humidity; D007223:Infant; D010100:Oxygen / Q000008:administration & dosage; D064705:Racepinephrine
D001993:Bronchodilator Agents; D005938:Glucocorticoids; D006371:Helium; D003907:Dexamethasone; D064705:Racepinephrine; D010100:Oxygen; D004837:Epinephrine