title: Memory protective effect of indomethacin against electroconvulsive shock-induced retrograde amnesia in rats.
abstract: BACKGROUND
  Nonsteroidal antiinflammatory drugs (NSAIDs) have been suggested to retard cognitive decrements in patients with Alzheimer's disease. We postulated that NSAIDs also may protect acute disruption of memory.
  
  
  METHODS
  We studied the effect of indomethacin (4 mg/kg/day) administered daily for 19 days on retrograde amnesia induced by two once-daily electroconvulsive shocks in rats.
  
  
  RESULTS
  Indomethacin produced statistically significant prolongation of recall latency in a passive avoidance task using a step-down apparatus.
  
  
  CONCLUSIONS
  Our study suggests that NSAIDs may prevent memory disruption through other mechanisms apart from attenuating chronic inflammation. In patients receiving electroconvulsive therapy, as in those diagnosed with Alzheimer's disease, antiinflammatory drugs may hold promise in the attenuation of cognitive impairments.
authors: Mental Health Unit, Royal Victoria Infirmary, Newcastle-upon-Tyne, United Kingdom.
authors: Sanjay Kumar
authors: SK
authors: Rao
authors: Chittaranjan
authors: C
authors: Andrade
authors: Kishore
authors: K
authors: Reddy
authors: K N
authors: KN
authors: Madappa
authors: Shivashanmugam
authors: S
authors: Thyagarajan
authors: Suresh
authors: S
authors: Chandra
mesh_terms: D000648:Amnesia, Retrograde / Q000517:prevention & control*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004597:Electroshock / Q000009:adverse effects*; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D008569:Memory Disorders / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin