Role of interleukin-18 in host defense against disseminated Candida albicans infection.
In mice injected intravenously with Candida albicans, administration of anti-interleukin-18 (IL-18) antibodies increased the yeast load in the kidneys. There was no effect on the organ load with Candida when gamma interferon (IFN-gamma)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-gamma.
Stuyt
Rogier J L
RJ
Department of Medicine, University Medical Center St. Radboud, Nijmegen, The Netherlands.
Netea
Mihai G
MG
Verschueren
Ineke
I
Fantuzzi
Giamila
G
Dinarello
Charles A
CA
Van Der Meer
Jos W M
JW
Kullberg
Bart Jan
BJ
D000818:Animals; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000097:blood / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology*; D007375:Interleukin-1 / Q000097:blood; D020382:Interleukin-18 / Q000097:blood / Q000276:immunology*; D015850:Interleukin-6 / Q000097:blood; D007668:Kidney / Q000276:immunology / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D018345:Mice, Knockout; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D007375:Interleukin-1; D020382:Interleukin-18; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma