Fas-ligand--iron fist or Achilles' heel?
Experimental and physiological expression of the pro-apoptotic molecule Fas-ligand can induce inflammation under certain conditions. Discussed here are the experimental situations, possible mechanisms, and pathways that mediate this response.
Hohlbaum
Andreas M
AM
Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Saff
Rebecca R
RR
Marshak-Rothstein
Ann
A
D000818:Animals; D017209:Apoptosis; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases / Q000502:physiology; D053222:Fas Ligand Protein; D006085:Graft Survival; D006801:Humans; D007249:Inflammation / Q000209:etiology; D008562:Membrane Glycoproteins / Q000502:physiology*
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; C505530:CASP8 protein, human; C506433:CASP9 protein, human; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases