Self-mutilation in rabbits following intramuscular ketamine-xylazine-acepromazine injections.
Following hind leg intramuscular injections of ketamine, xylazine, and acepromazine, 4 of 6 rabbits exhibited self-mutilation of the digits. At necropsy, the affected sciatic nerve appeared enlarged. Lymphohistiocytic perineural inflammation and fibrosis were observed, together with nerve degeneration. Neuronal regeneration as the reason for self-mutilation is discussed.
Vachon
P
P
CHUM Campus Notre-Dame, Centre de Recherche L.C. Simard, 1560 Sherbrooke est, Montréal, Québec, H2L 4M1.
D000075:Acepromazine / Q000008:administration & dosage / Q000009:adverse effects*; D019162:Anesthetics, Combined / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D001369:Axons / Q000473:pathology; D007273:Injections, Intramuscular / Q000009:adverse effects / Q000662:veterinary; D007649:Ketamine / Q000008:administration & dosage / Q000009:adverse effects*; D009410:Nerve Degeneration / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D011817:Rabbits / Q000293:injuries*; D012652:Self Mutilation / Q000209:etiology*; D014991:Xylazine / Q000008:administration & dosage / Q000009:adverse effects*
D019162:Anesthetics, Combined; D014991:Xylazine; D000075:Acepromazine; D007649:Ketamine