title: CJ-21,164, a new D-glucose-6-phosphate phosphohydrolase inhibitor produced by a fungus Chloridium sp.
abstract: A new D-glucose-6-phosphate phosphohydrolase (G6Pase) inhibitor, CJ-21,164 (1) was isolated from the fermentation broth of the fungus Chloridium sp. CL48903. The structure was elucidated to be a novel tetramer of the salicylic acid derivatives by spectroscopic analyses. Compound I inhibited G6Pase in rat liver microsomes with an IC50 of 1.6 microM. Glucose output from hepatocytes isolated from rat liver was inhibited when I was present in the incubation medium, consistent with the role of I as a G6Pase inhibitor.
authors: Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc, Chita-gun, Aichi, Japan. Yoon-Jeong.Kim@japan.pfizer.com
authors: Yoon-Jeong
authors: YJ
authors: Kim
authors: Hiroyuki
authors: H
authors: Nishida
authors: Chang-Hong
authors: CH
authors: Pang
authors: Toshiyuki
authors: T
authors: Saito
authors: Shinichi
authors: S
authors: Sakemi
authors: Hiroko
authors: H
authors: Tonai-Kachi
authors: Nobuji
authors: N
authors: Yoshikawa
authors: Maria A
authors: MA
authors: Vanvolkenburg
authors: Janice C
authors: JC
authors: Parker
authors: Yasuhiro
authors: Y
authors: Kojima
mesh_terms: D000818:Animals; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005947:Glucose / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D015394:Molecular Structure; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001565:Benzoates; C455259:CJ 21164; D004791:Enzyme Inhibitors; D010744:Phosphoric Monoester Hydrolases; D005947:Glucose