title: Recent progress in alpha 1-adrenoceptor pharmacology.
abstract: The adrenoceptors (ARs) play a key role in the modulation of sympathetic nervous system activity and are a site of action for many clinically important therapeutic agents. The alpha1-adrenoceptor subtypes (alpha1A-, alpha1B-, and alpha1D-AR) play a prominent role in regulating vascular tone and hypertrophic growth of smooth muscle and cardiac cells. Their functional characteristics with respect to ligand binding and second messenger utilization have been well described. Here, we review recent progress on subtype-specific subcellular localization, participation in signaling cascades, and the pivotal function of alpha1-ARs, as delineated through studies on genetically engineered animals. Together, these findings will provide new insights into the physiological and pathophysiological roles of the alpha1-ARs.
authors: Department of Molecular, Cell Pharmacology, National Children's Medical Research Center, Tokyo, Japan.
authors: Taka-aki
authors: TA
authors: Koshimizu
authors: Junji
authors: J
authors: Yamauchi
authors: Akira
authors: A
authors: Hirasawa
authors: Akito
authors: A
authors: Tanoue
authors: Gozoh
authors: G
authors: Tsujimoto
mesh_terms: D018663:Adrenergic Agents / Q000494:pharmacology*; D000818:Animals; D017850:Economics, Pharmaceutical / Q000706:statistics & numerical data; D006801:Humans; D018340:Receptors, Adrenergic, alpha-1 / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D018663:Adrenergic Agents; D018340:Receptors, Adrenergic, alpha-1