Local treatment of HPV-induced skin lesions by Cidofovir.
Human papillomavirus (HPV) induced epithelial cell proliferation is responsible for a broad range of lesions. Treatment of such lesions is characterized by a high relapse rate. Four patients are described who were treated locally with cidofovir (cream 1% or injection of 2.5 mg/ml solution) for multi-treated relapsing HPV-associated lesions. Three of the four patients had a complete response. The fourth patient showed a clinical response in the first cycle of treatment, but new lesions appeared during four successive cycles of cidofovir.
Stragier
Ilse
I
Department of Dermatology, U.Z. Leuven, Leuven, Belgium.
Snoeck
Robert
R
De Clercq
Erik
E
Van Den Oord
Joost J
JJ
Van Ranst
Marc
M
De Greef
Hugo
H
D000287:Administration, Topical; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000077404:Cidofovir; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000821:virology; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D027383:Papillomaviridae / Q000187:drug effects; D016896:Treatment Outcome; D014860:Warts / Q000188:drug therapy* / Q000821:virology
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir