title: Dose-response relationships for foot and mouth disease in cattle and sheep.
abstract: The relationships between the inhaled dose of foot and mouth disease virus and the outcomes of infection and disease were examined by fitting dose-response models to experimental data. The parameters for both the exponential and beta-poisson models were estimated using maximum likelihood and Bayesian methods. The median probability of infection given a single inhaled TCID50 was estimated to be 0.031 with 95% Bayesian credibility intervals (CI) of 0.018-0.052 for cattle, and 0.045 (CI = 0.024-0.080) for sheep. These estimates were used to construct dose-response curves and uncertainty distributions for use in quantitative risk assessments.
authors: Department of Veterinary Clinical Science and Animal Husbandry, University of Liverpool, Neston, S. Wirral.
authors: N P
authors: NP
authors: French
authors: L
authors: L
authors: Kelly
authors: R
authors: R
authors: Jones
authors: D
authors: D
authors: Clancy
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000635:transmission*; D005536:Foot-and-Mouth Disease / Q000635:transmission*; D029544:Foot-and-Mouth Disease Virus / Q000472:pathogenicity*; D019570:Inhalation Exposure; D008962:Models, Theoretical; D018570:Risk Assessment; D012756:Sheep; D012757:Sheep Diseases / Q000635:transmission*