title: The catalytic asymmetric Mannich-type reactions in aqueous media.
abstract: The catalytic, diastereo- and enantioselective Mannich-type reaction of a hydrazono ester with silyl enol ethers in aqueous media has been successfully achieved with ZnF(2), a chiral diamine ligand, and trifluoromethanesulfonic acid.
authors: Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, Japan.
authors: Shū
authors: S
authors: Kobayashi
authors: Tomoaki
authors: T
authors: Hamada
authors: Kei
authors: K
authors: Manabe
mesh_terms: D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D003959:Diamines / Q000737:chemistry; D005459:Fluorides / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis*; D014867:Water / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D000588:Amines; D003959:Diamines; D007659:Ketones; D017967:Zinc Compounds; D014867:Water; C038904:zinc fluoride; D005459:Fluorides