[Alpha2-macroglobulin gene polymorphism in patients with Alzheimer's disease].
Recent studies suggest that alpha 2-macroglobulin (alpha 2 m) may play a role in the pathogenesis of Alzheimer's Disease (AD). The presence of alpha 2-macroglobulin G/G genotype is thought to increase the risk of AD. The aim of the study was to analyse alpha 2 m polymorphism in two groups: AD patients (n = 60, F = 41, M. = 19, mean age 73.3 +/- 6.3) and non-demented control group (n = 58, F = 36, M. = 22, mean age 73.1 +/- 8.3, mean MMSE score 27). Frequencies of genotypes A/A, A/G, G/G in AD group were: 0.46: 0.42: 0.12. In control group those frequencies were: 0.40: 0.48: 0.12. The lack of statistically significant difference between G/G frequencies in both groups of patients may suggest that alpha 2-macroglobulin G/G genotype is not a risk factor for AD.
Styczyńska
M
M
Zespołu Badawczo-Leczniczego Chorób Zwyrodnieniowych CUN Centrum Medycyny Doświadczalnej i Klinicznej PAN/MSWiA. desperat@cmdik.pan.pl
Wasiak
B
B
Łuczywek
E
E
Pfeffer
A
A
Barcikowska
M
M
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D011110:Polymorphism, Genetic; D012307:Risk Factors; D000511:alpha-Macroglobulins / Q000235:genetics*
D000511:alpha-Macroglobulins; D004247:DNA