Breast cancer: regional blood flow and blood volume measured with magnetic susceptibility-based MR imaging--initial results.
The purpose of this study was to quantify microcirculation in breast neoplasms with magnetic susceptibility-based contrast material-enhanced magnetic resonance imaging. With this imaging method for invasive cancers, the mean values of the ratios of tumor to normal blood flow and blood volume were significantly higher (P <.002) than those for benign or normal tissue. The method allows independent measurement of regional blood flow and blood volume in breast cancers.
Delille
Jean-Paul
JP
Department of Radiology, NMR Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Slanetz
Priscilla J
PJ
Yeh
Eren D
ED
Kopans
Daniel B
DB
Garrido
Leoncio
L
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001810:Blood Volume; D001943:Breast Neoplasms / Q000098:blood supply* / Q000473:pathology*; D003287:Contrast Media; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D016014:Linear Models; D008833:Microcirculation; D008875:Middle Aged; D011446:Prospective Studies; D012039:Regional Blood Flow
D003287:Contrast Media