title: Simultaneously monitoring both T(1) and T(2)* signal intensities on a bolus injection of Gd-DTPA may distinguish infarcted myocardium.
abstract: OBJECTIVE
  To determine whether injured myocardium may be identified by simultaneously monitoring contrast-induced T(1) and T(2)* signal intensity time-course changes with an interleaved T(1)-T(2)* imaging sequence.
  
  
  METHODS
  Gadolinium-diethylene triamine pentaacetic acid (0.05 mmol/ kg) was injected as a bolus into ex vivo pig hearts, and simultaneous T(1) and T(2)* time-courses were obtained during the first pass.
  
  
  RESULTS
  Observing contrast-enhanced R(1) or R(2)* rates (1/T(1) or 1/T(2)* times, respectively) early after contrast injection did not fully differentiate viable from nonviable myocardium. T(2)* recovery at maximal T(1) signal intensity, measured using simultaneous T(1) and T(2)* imaging, displayed a significantly different percentage recovery (P < 0.05) among normal (30.5 +/- 2.4% of baseline value), reperfused infarcted (63 +/- 7.2%), and low-reflow infarcted (90 +/- 2.8%) myocardium.
  
  
  CONCLUSIONS
  Simultaneously monitoring both T(1) and T(2)* signal intensities may help in the assessment of myocardial injury.
authors: Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada.
authors: John
authors: J
authors: Mark
authors: Guangping
authors: G
authors: Dai
authors: Bo
authors: B
authors: Xiang
authors: Jiankang
authors: J
authors: Sun
authors: Normand
authors: N
authors: Lazarow
authors: William G
authors: WG
authors: Lindsay
authors: Robert
authors: R
authors: Corne
authors: Roxanne
authors: R
authors: Deslauriers
authors: Ganghong
authors: G
authors: Tian
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D019786:Gadolinium DTPA / Q000008:administration & dosage; D007275:Injections, Intravenous; D008863:Microspheres; D009203:Myocardial Infarction / Q000175:diagnosis*; D012039:Regional Blood Flow; D013552:Swine
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA