Characterization of Klebsiella pneumoniae and Escherichia coli strains that produce CTX-M-2-type broad spectrum beta-lactamase isolated from a child with leukemia.
An 8-year-old girl with acute leukemia had bacteremia caused by Klebsiella pneumoniae producing CTX-M-2-type broad spectrum beta-lactamase. K. pneumoniae and Escherichia coli strains producing the same enzyme and harboring identical conjugative plasmids were recovered from stoor culture. Patients with frequent episodes of neutropenia and prophylactic administration of beta-lactams are at risk of harboring colonizing strains that produce broad spectrum beta-lactamases.
Ohkawa
Toshiya
T
Department of Pediatrics, Faculty of Medicine, Kagoshima University, Japan.
Yoshinaga
Masao
M
Ikarimoto
Naoaki
N
Miyanohara
Hiroaki
H
Miyata
Koichiro
K
Doi
Yohei
Y
Shibata
Naohiro
N
Arakawa
Yoshichika
Y
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002675:Child, Preschool; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D007711:Klebsiella pneumoniae / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000382:microbiology*; D013379:Substrate Specificity; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; C071167:beta-lactamase CTX-2; D001618:beta-Lactamases