The type 2 human somatostatin receptor as a platform for reporter gene imaging.
The human somatostatin receptor subtype 2A (hSSTr2) is under evaluation as a reporter gene for molecular imaging applications. Two approved somatostatin analogues are already available for imaging expression of the reporter gene following delivery with adenoviral (Ad) vectors or other genetic targeting strategies. In animal models, Ad-mediated expression of hSSTr2 in subcutaneous and intraperitoneal tumors was detected by non-invasive gamma camera imaging. This review discusses the rationale and strategy for using the hSSTr2 reporter gene as a platform for imaging applications.
Zinn
Kurt R
KR
Department of Radiology, University of Alabama at Birmingham, 35294, USA. kurtzinn@uab.edu
Chaudhuri
Tandra R
TR
D015870:Gene Expression; D005786:Gene Expression Regulation; D018014:Gene Transfer Techniques; D017930:Genes, Reporter / Q000235:genetics*; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D006801:Humans; D008957:Models, Genetic; D008958:Models, Molecular; D011868:Radioisotopes; D011877:Radionuclide Imaging / Q000379:methods*; D017481:Receptors, Somatostatin / Q000235:genetics*; D014407:Tumor Cells, Cultured / Q000000981:diagnostic imaging*
D011868:Radioisotopes; D017481:Receptors, Somatostatin; C093733:somatostatin receptor 2