title: A role for CD147 in thymic development.
abstract: We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCRbeta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.
authors: Centre d'Immunologie Pierre Fabre, 5 Avenue Napoleon III, Saint-Julien en Genevois, 74160 France.
authors: Toufic
authors: T
authors: Renno
authors: Anne
authors: A
authors: Wilson
authors: Caroline
authors: C
authors: Dunkel
authors: Isabelle
authors: I
authors: Coste
authors: Karine
authors: K
authors: Maisnier-Patin
authors: Amélie
authors: A
authors: Benoit de Coignac
authors: Jean-Pierre
authors: JP
authors: Aubry
authors: Rosemary K
authors: RK
authors: Lees
authors: Jean-Yves
authors: JY
authors: Bonnefoy
authors: H Robson
authors: HR
authors: MacDonald
authors: Jean-François
authors: JF
authors: Gauchat
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D030161:Avian Proteins; D001483:Base Sequence; D051926:Basigin; D001666:Binding Sites, Antibody / Q000235:genetics; D001798:Blood Proteins; D002453:Cell Cycle / Q000235:genetics / Q000276:immunology; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D002460:Cell Line; D003001:Cloning, Molecular; D005260:Female; D005333:Fetus; D006801:Humans; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D009924:Organ Culture Techniques; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology* / Q000276:immunology* / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D030161:Avian Proteins; C497886:BSG protein, human; D001798:Blood Proteins; C102624:Bsg protein, Gallus gallus; C497887:Bsg protein, mouse; C079432:Bsg protein, rat; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D051926:Basigin