title: Risk to human health from a plethora of simian immunodeficiency viruses in primate bushmeat.
abstract: To assess human exposure to Simian immunodeficiency virus (SIV) in west central Africa, we looked for SIV infection in 788 monkeys that were hunted in the rainforests of Cameroon for bushmeat or kept as pets. Serologic reactivity suggesting SIV infection was found in 13 of 16 primate species, including 4 not previously known to harbor SIV. Overall, 131 sera (16.6%) reacted strongly and an additional 34 (4.3%) reacted weakly with HIV antigens. Molecular analysis identified five new phylogenetic SIV lineages. These data document for the first time that a substantial proportion of wild monkeys in Cameroon are SIV infected and that humans who hunt and handle bushmeat are exposed to a plethora of genetically highly divergent viruses.
authors: Institue de Recherche pour la Développement, Laboratoire Retrovirus, 911 Avenue Agropolis, BP 5045, 34032 Montpellier cedex 1, France. martine.peeters@mpl.ird.fr
authors: Martine
authors: M
authors: Peeters
authors: Valerie
authors: V
authors: Courgnaud
authors: Bernadette
authors: B
authors: Abela
authors: Philippe
authors: P
authors: Auzel
authors: Xavier
authors: X
authors: Pourrut
authors: Frederic
authors: F
authors: Bibollet-Ruche
authors: Severin
authors: S
authors: Loul
authors: Florian
authors: F
authors: Liegeois
authors: Cristelle
authors: C
authors: Butel
authors: Denis
authors: D
authors: Koulagna
authors: Eitel
authors: E
authors: Mpoudi-Ngole
authors: George M
authors: GM
authors: Shaw
authors: Beatrice H
authors: BH
authors: Hahn
authors: Eric
authors: E
authors: Delaporte
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000097:blood / Q000276:immunology / Q000821:virology; D000835:Animals, Wild / Q000097:blood / Q000276:immunology / Q000821:virology; D002163:Cameroon; D003429:Cross Reactions; D019143:Evolution, Molecular; D006678:HIV / Q000276:immunology; D000882:Haplorhini / Q000097:blood / Q000276:immunology / Q000821:virology*; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D008460:Meat / Q000821:virology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors; D012698:Serologic Tests; D016097:Simian Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology / Q000635:transmission* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*
chemical_list: D007106:Immune Sera