Only connect: linking meiotic DNA replication to chromosome dynamics.
The process of meiosis reduces a diploid cell to four haploid gametes and is accompanied by extensive recombination. Thus, chromosome dynamics in meiosis are significantly different than in mitotic cells. This review analyzes unique features of meiotic DNA replication and describes how it affects subsequent recombination and chromosome segregation.
Forsburg
Susan L
SL
Molecular and Cell Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. forsburg@salk.edu
D018797:Cell Cycle Proteins / Q000502:physiology; D002842:Chromatids / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone; D020090:Chromosome Segregation / Q000502:physiology*; D002875:Chromosomes / Q000235:genetics / Q000502:physiology; D015825:Chromosomes, Fungal / Q000235:genetics / Q000502:physiology; D004261:DNA Replication / Q000502:physiology*; D005656:Fungal Proteins; D018816:Genes, cdc; D008540:Meiosis / Q000235:genetics*; D008938:Mitosis; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000502:physiology; D010750:Phosphoproteins; D011995:Recombination, Genetic; D018741:Replication Origin; D016196:S Phase; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology; D012568:Schizosaccharomyces / Q000166:cytology / Q000235:genetics; D029702:Schizosaccharomyces pombe Proteins / Q000502:physiology; D000097722:Cohesins
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D005656:Fungal Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; D000097722:Cohesins; C490529:MCD1 protein, S cerevisiae; C077081:REC8 protein, S pombe