Conformational properties of N',N'-dimethylamides of N-acetyldehydroalanine and N-acetyl-(Z)-dehydrophenylalanine.
Conformational preferences of Ac-deltaAla-NMe2 and Ac-(Z)-deltaPhe-NMe2 were studied and compared with those of their monomethyl counterparts as well as with those of their saturated analogues. X-Ray data and energy calculations revealed a highly conservative conformation of the dehydro dimethylamides, which is located in a high-energy region of the Ramachandran map.
Siodłak
D
D
Institute of Chemistry, University of Opole, Poland.
Broda
M A
MA
Rzeszotarska
B
B
Kozioł
A E
AE
Dybała
I
I
D000409:Alanine / Q000031:analogs & derivatives / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000737:chemistry*; D011487:Protein Conformation; D017434:Protein Structure, Tertiary
C457541:N-acetyldehydroalanine; C457542:N-acetyldehydrophenylalanine; D010649:Phenylalanine; D000409:Alanine