hOGG1 Ser(326)Cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese.
Oxidative stress is involved in many types of DNA damage, e.g., resulting in 8-hydroxyguanine adducts. Since a human counterpart exists for the yeast gene OGG1 (hOGG1) encoding an enzyme that repairs 8-hydroxyguanine, its polymorphism, Ser(326)Cys, might have potential as a genetic marker for cancer susceptibility. To investigate its association with stomach cancer risk and possible interactions with environmental factors, we conducted a case-control study of 101 stomach cancer cases and 198 controls using PCR-single-strand conformation polymorphism and a questionnaire approach. The proportional distribution of the Cys/Cys alleles did not differ between stomach cancer cases and controls, but subgroup analyses revealed that a frequent drinking habit elevated the odds ratio (OR) for stomach cancer in Cys/Cys compared to Ser/Ser and Ser/Cys carriers. The ORs with frequent consumption of pickled vegetables and meat tended to be higher in Cys/Cys than in Ser/Ser and Ser/Cys carriers, these interactions being on the borderline of statistical significance. Our findings suggest that the hOGG1 Ser(326)Cys polymorphism may alter the impact of some environmental factors on stomach cancer development. For confirmation, an additional study with a larger number of subjects is now required.
Takezaki
Toshiro
T
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan. ttakezak@aichi-cc.jp
Gao
Chang-ming
CM
Wu
Jian-zhong
JZ
Li
Zhong-you
ZY
Wang
Jian-dong
JD
Ding
Jian-hua
JH
Liu
Yan-ting
YT
Hu
Xu
X
Xu
Tian-liang
TL
Tajima
Kazuo
K
Sugimura
Haruhiko
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D000483:Alleles; D002681:China; D003545:Cysteine / Q000737:chemistry*; D043382:DNA-Formamidopyrimidine Glycosylase; D004777:Environment; D004938:Esophageal Neoplasms / Q000235:genetics*; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009699:N-Glycosyl Hydrolases / Q000235:genetics*; D016017:Odds Ratio; D018384:Oxidative Stress; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018807:Polymorphism, Single-Stranded Conformational; D012694:Serine / Q000737:chemistry*; D012907:Smoking; D013274:Stomach Neoplasms / Q000235:genetics*
D012694:Serine; C024829:8-hydroxyguanine; D006147:Guanine; D009699:N-Glycosyl Hydrolases; D043382:DNA-Formamidopyrimidine Glycosylase; D003545:Cysteine