The catalytic asymmetric Mannich-type reactions in aqueous media.
The catalytic, diastereo- and enantioselective Mannich-type reaction of a hydrazono ester with silyl enol ethers in aqueous media has been successfully achieved with ZnF(2), a chiral diamine ligand, and trifluoromethanesulfonic acid.
Kobayashi
Shū
S
Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, Japan.
Hamada
Tomoaki
T
Manabe
Kei
K
D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D003959:Diamines / Q000737:chemistry; D005459:Fluorides / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis*; D014867:Water / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry
D000588:Amines; D003959:Diamines; D007659:Ketones; D017967:Zinc Compounds; D014867:Water; C038904:zinc fluoride; D005459:Fluorides