Randomized trial of one versus two transcervical insertions of quinacrine pellets for sterilization.
OBJECTIVE
To determine the relative effectiveness of single vs. two transcervical monthly insertions of 252 mg of quinacrine for female sterilization.


METHODS
Controlled clinical study.


METHODS
Family planning clinics of 6 academic centers.


METHODS
Sexually active reproductive-age women requesting sterilization.


METHODS
At each of six centers 70 and 30 women were randomly assigned to receive either one or two, respectively, monthly transcervical insertions to the fundus of 252 mg of quinacrine and 75 mg of diclofenac as pellets and they were followed for 1 year.


METHODS
Complications, side effects, and pregnancy failures.


RESULTS
There were no serious complications and side effects were transient and easily treated. There were 31 (7.4%) pregnancy failures in the single insertions group and 2 (1.1%) in the two insertions group, but with marked center variation.


CONCLUSIONS
Quinacrine sterilization using two monthly insertions of 252 mg of quinacrine appears safe and reasonably effective.
Agoestina
Tina
T
Department of Obstetrics and Gynecology, Dr. Hasan Sadikin Hospital/Medical School, Padjadaran University, Bandung, Indonesia. dragias@bdg.centrin.net.id
Hoesni
R Hasan M
RH
Purwara
Benny Hasan
BH
Santoso
Budi Iman
BI
Siswanto
Padjar
P
Dasuki
Djaswadi
D
Samsulhadi
A
A
Surya
Gede Putu
GP
D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D015993:Life Tables; D011247:Pregnancy; D018873:Pregnancy Rate; D011796:Quinacrine / Q000008:administration & dosage* / Q000009:adverse effects; D013246:Sterilization, Tubal / Q000379:methods; D016896:Treatment Outcome
D011796:Quinacrine