title: [Cloning and analysis of human alpha-1B glycoprotein precursor gene: a novel member of human immunoglobulin superfamily].
abstract: A cDNA of 1694 bp was cloned from human liver Marathon cDNA by means of Rapid Amplification of cDNA Ends (RACE). The cDNA has an open reading frame at 43-1530 bp encoding 495 amino acid residues and a 17-residue signal peptide. There are four Igc2 domains in the translated polypeptide, which is highly homologous to the human alpha-1B glycoprotein isolated from human plasma. Upon this, we conclude that this cDNA is the alpha-1B glycoprotein precursor gene which has never been cloned before, and it may be a novel member of immunoglobulin superfamily and may involved in the cell recognition and the regulation of cell behavior.
authors: Department of Medical Genetics, China Medical University, Shenyang 110001, China.
authors: Di
authors: D
authors: Sun
authors: Yan-Yan
authors: YY
authors: Zhao
authors: Shu-Ping
authors: SP
authors: Dai
authors: Kai
authors: K
authors: Fang
authors: Ling-Yue
authors: LY
authors: Dong
authors: Qian
authors: Q
authors: Ding
mesh_terms: D001798:Blood Proteins / Q000235:genetics* / Q000502:physiology; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry; D006023:Glycoproteins; D006801:Humans; D007136:Immunoglobulins; D011498:Protein Precursors / Q000235:genetics*
chemical_list: C048566:A1BG protein, human; D001798:Blood Proteins; D018076:DNA, Complementary; D006023:Glycoproteins; D007136:Immunoglobulins; D011498:Protein Precursors