[Successful treatment of invasive pulmonary aspergillosis with G-CSF and M-CSF during long-term bone marrow suppression in hypoplastic leukemia].
A 52-year-old man was admitted for treatment of hypoplastic leukemia (M 1). After induction chemotherapy with IDR and AraC, the patient developed prolonged febrile neutropenia, and a diagnosis of invasive pulmonary aspergillosis was made. We started administration of AMPH-B and G-CSF, but the patient showed no clinical improvement. M-CSF was added to the regimen, and this led to an increase in the white blood cell count with resolution of pneumonia. It is suggested that administration of M-CSF with antibiotics and G-CSF may be beneficial for treating acute leukemia patients with prolonged febrile neutropenia after intensive chemotherapy.
Nishii
Kazuhiro
K
Second Department of Internal Medicine, Mie University School of Medicine.
Mitani
Hidetsugu
H
Miyashita
Hiroyuki
H
Hoshino
Natsuki
N
Usui
Eiji
E
Sakakura
Miho
M
Nishikawa
Hiroyoshi
H
Katayama
Naoyuki
N
Kobayashi
Tohru
T
Shiku
Hiroshi
H
D001228:Aspergillosis / Q000209:etiology / Q000628:therapy*; D001853:Bone Marrow / Q000503:physiopathology*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000628:therapy*; D008172:Lung Diseases, Fungal / Q000209:etiology / Q000628:therapy*; D016173:Macrophage Colony-Stimulating Factor / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged
D016179:Granulocyte Colony-Stimulating Factor; D016173:Macrophage Colony-Stimulating Factor