Dietary iron-deficiency up-regulates hephaestin mRNA level in small intestine of rats.
Hephaestin is a protein, recently found from the study of sla (sex-linked anemia) mouse. Hephaestin is suggested to transport iron from intestinal enterocytes into the circulation. Iron is essential for living and for humans to maintain a constant total iron concentration in whole body. In this study, it was found that dietary iron-deficiency up-regulated hephaestin mRNA level in the proximal small intestine of rats. Therefore, it is suggested that in dietary iron-deficiency, hephaestin gene expression in proximal small intestine is up-regulated to absorb more iron from diet.
Sakakibara
Shoji
S
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Nishi-9, Kita-9, Kita-ku, 060-8589, Sapporo, Japan.
Aoyama
Yoritaka
Y
D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D000818:Animals; D002570:Ceruloplasmin / Q000096:biosynthesis / Q000378:metabolism; D004032:Diet; D015870:Gene Expression; D006454:Hemoglobins / Q000032:analysis; D007421:Intestine, Small / Q000378:metabolism*; D000090463:Iron Deficiencies; D008099:Liver / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation
D006454:Hemoglobins; C492163:Heph, protein, rat; D008565:Membrane Proteins; D012333:RNA, Messenger; D002570:Ceruloplasmin