[Effects of para-aminobenzoic acid on radiosensitivity of mice of different strains].
The aim of the work was to study the possible protective effect of para-aminobenzoic acid (PABA) on the radiation lethality in mice of three inbred lines (BALB/cLacY, C3H/HeY, 101/Hy), stock YT1 and hybrids (C3H/He x 101/H)F1. The PABA solution was given to the mice intraperitoneally in single doses of 10, 50 and 100 mg/kg 40-50 min prior to irradiation with doses of 6 to 8 Gy depending on the line and sex of mice. The used doses of gamma-radiation were roughly LD75/30. The radioprotective effect of PABA was observed in all variants of the experiment but it was relatively low. The protection coefficient varied from 0 to 0.45. The protective effect depended on the line and sex of mice and on the dose of the injected substance.
Ramaĭia
L K
LK
Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991 Russia.
Pomerantseva
M D
MD
Malashenko
A M
AM
D010129:4-Aminobenzoic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005720:Gamma Rays; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D008962:Models, Theoretical; D011829:Radiation Dosage; D011837:Radiation-Protective Agents; D012737:Sex Factors; D013473:Sunscreening Agents / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D013473:Sunscreening Agents; D010129:4-Aminobenzoic Acid