Structure-antiemetic-activity of some diarylheptanoids and their analogues.
The structure-activity relationship of diarylheptanoids and their analogues inhibitory of emesis induced by copper sulfate in young chicks was investigated by testing 19 compounds. The compounds are 5 diarylheptanoids isolated from Alpinia katsumadai (Zingiberacea), 5 chemical derivatives of them, 6 analogues isolated from Zingiber officinale rhizome (Zingiberaceae), and 3 analogues available on the market. Among them, two types of essential functional structure of diarylheptanoids and their analogues showed the inhibitory effects against emesis.
Yang
Y
Y
Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Tokyo, Japan.
Kinoshita
K
K
Koyama
K
K
Takahashi
K
K
Kondo
S
S
Watanabe
K
K
D000818:Animals; D000932:Antiemetics / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002396:Catechols / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002645:Chickens; D019327:Copper Sulfate / Q000494:pharmacology; D005233:Fatty Alcohols / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D020939:Zingiber officinale / Q000737:chemistry; D006536:Heptanes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy; D030521:Zingiberaceae
D000932:Antiemetics; D002396:Catechols; D005233:Fatty Alcohols; D006536:Heptanes; D010936:Plant Extracts; C040115:shogaol; C007845:gingerol; D019327:Copper Sulfate