Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I.
Linear and cyclic hymenistatin I (HS I) analogues with dipeptide segments Ile2-Pro3 Pro3-Pro4 and Val6-Pro7 replaced by their tetrazole analogues Ile2-psi[CN4]-Ala3', Pro3-psi[CN4]-Ala4 and Val6-psi[CN4]-Ala7 were synthesized by the solid phase peptide synthesis method and cyclized with the TBTU and/or HATU reagent. The peptides were examined for their immunosuppressive activity in the lymphocyte proliferation test (LPT).
Zubrzak
P
P
Institute of Organic Chemistry, Technical University of Lódź, Poland.
Kociołek
K
K
Smoluch
M
M
Silberring
J
J
Kowalski
M L
ML
Szkudlińska
B
B
Zabrocki
J
J
D000595:Amino Acid Sequence; D002455:Cell Division; D006801:Humans; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D008214:Lymphocytes / Q000166:cytology; D008956:Models, Chemical; D008969:Molecular Sequence Data; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D013777:Tetrazoles / Q000737:chemistry*
D007166:Immunosuppressive Agents; D010455:Peptides; D010456:Peptides, Cyclic; D013777:Tetrazoles; C101065:hymenistatin I