A variant of acrokeratoelastoidosis in systemic scleroderma: report of 7 cases.
We describe acrokeratoelastoidosis-like lesions on the palms of the patients with systemic scleroderma. Histology showed a focal hyperkeratosis with or without epidermal concavity, regular acanthosis, and hyalinization of collagen fibers and, in some cases, fragmentation and diminution of elastic fibers in the deep dermis. A slight degree of fibrotic change of collagen in the uninvolved neighboring skin was found in one case. The lesions were found in 7 of 26 patients with systemic scleroderma who were analyzed here, and were not found in the unrelated connective tissue disorders (n = 32) and normal controls (n = 27). The cause of the unique skin lesions may be related to the altered connective tissue metabolism similar to that of systemic scleroderma.
Tajima
Shingo
S
Department of Dermatology, National Defense Medical College, Tokorozawa, Saitama, Japan. tajimas@ndmc.ac.jp
Tanaka
Nobuhiko
N
Ishibashi
Akira
A
Suzuki
Kimihiro
K
D000328:Adult; D001707:Biopsy, Needle; D016022:Case-Control Studies; D003240:Connective Tissue Diseases / Q000473:pathology*; D003937:Diagnosis, Differential; D004548:Elasticity; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007642:Keratosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D012595:Scleroderma, Systemic / Q000473:pathology*