title: Investigation of irritant skin reaction by 10% povidone-iodine solution after surgery.
abstract: We report 19 patients who developed extensive patchy or linear erythema on both sides of the buttocks, the back and the posterior areas of the thighs within a few days following operations or cardioangiography. The erythema was sometimes deeply infiltrative and was also accompanied by bullae and erosion. Patch tests of the patients were strongly positive for 10% povidone-iodine (PVP-I, Isodine) solution; however, they were negative for 10% PVP-I solution with the same amount of 8% sodium thiosulfate and for 5% potassium iodide in petrolatum. In all control individuals, the only positive result was that of a patch test with 10% PVP-I solution within 8 h after application. We diagnosed our patients as having irritant contact dermatitis caused by 10% PVP-I solution during the procedure, which might have drained along the skin to the side of the buttocks or the back. We here indicate that prolonged contact with a large quantity of 10% PVP-I solution should be avoided to prevent this problem.
authors: Department of Dermatology, Mito Saiseikai General Hospital, Ibaraki, Japan. skmf-i@d7.dion.ne.jp
authors: Shingeruko
authors: S
authors: Iijima
authors: Miyako
authors: M
authors: Kuramochi
mesh_terms: D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology*; D011206:Povidone-Iodine / Q000009:adverse effects*
chemical_list: D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine