Past, present and future of HIV vaccine trials in developing countries.
A safe, effective and accessible preventive vaccine is our best long-term hope for the control of the HIV/AIDS pandemic. The first phase I trial of an HIV vaccine was conducted in the US in 1987. Since then, >30 candidate vaccines have been tested in over 60 phase I/II clinical trials, involving >8000 healthy human volunteers. The majority of these trials have been conducted in the US and Europe, however, trials have also been conducted in developing countries (Brazil, China, Cuba, Haiti, Kenya, Thailand, and Uganda), including an ongoing phase III efficacy trial of a rgp120 candidate vaccine in Thailand. The effort to develop and evaluate HIV vaccines must increase, especially in Africa.
Esparza
José
J
WHO-UNAIDS HIV Vaccine Initiative, World Health Organisation, 1211 Geneva, Switzerland. esparzaj@who.ch
Osmanov
Saladin
S
Pattou-Markovic
Claire
C
Touré
Coumba
C
Chang
Marie Louise
ML
Nixon
Stephanie
S
D016915:AIDS Vaccines; D002986:Clinical Trials as Topic; D017326:Clinical Trials, Phase III as Topic; D003906:Developing Countries; D005544:Forecasting; D015658:HIV Infections / Q000517:prevention & control; D006801:Humans
D016915:AIDS Vaccines