Shogaols from Zingiber officinale protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from beta-amyloid(25-35) insult.
From the rhizome of Zingiber officinale L. (Zingiberaceae), four shogaols that protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from beta-amyloid(25 - 35) insult at EC50 = 4.5 - 81 microM were isolated. The efficacy of cell protection from beta-amyloid(25 - 35) insult by these shogaols was shown to improve as the length of the side chain increases.
Kim
Darrick S H L
DS
Kim
Dong-Seon
DS
Oppel
Marissa N
MN
D016229:Amyloid beta-Peptides / Q000494:pharmacology; D002396:Catechols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects*; D020939:Zingiber officinale; D006801:Humans; D009447:Neuroblastoma / Q000188:drug therapy / Q000473:pathology; D010446:Peptide Fragments / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D014407:Tumor Cells, Cultured; D014471:Umbilical Veins / Q000166:cytology / Q000187:drug effects; D024502:alpha-Tocopherol / Q000494:pharmacology
D016229:Amyloid beta-Peptides; D002396:Catechols; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35); C040115:shogaol; D024502:alpha-Tocopherol; D003474:Curcumin