title: Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets.
abstract: BACKGROUND
  Tumor markers such as CA130 can be determined in human whole saliva. Saliva represents an attractive body fluid for longitudinal studies.
  
  
  METHODS
  CA130 was determined in parotid saliva from 8 rats fed different diets, with or without autonomic denervation.
  
  
  RESULTS
  CA130 could be determined in parotid saliva of rats, irrespective of diet and/or autonomic denervation. Whether the numerical decrease in CA130 observed after autonomic denervation is statistically significant requires further work.
  
  
  CONCLUSIONS
  Since salivary CA130 has been shown to decrease following treatment with anti-cancer drugs in humans, the ability to determine this tumor marker in rat saliva opens new opportunities for optimizing cancer chronotherapy in the experimental laboratory.
authors: Department of Community Dentistry, Dental School, University of Texas Health Science Center, San Antonio, TX 78284, USA.
authors: Dorthea
authors: D
authors: Johnson-Alvares
authors: Germaine
authors: G
authors: Cornélissen
authors: Ana
authors: A
authors: Portela
authors: Erna
authors: E
authors: Halberg
authors: Joel D
authors: JD
authors: Rudney
authors: Chih-Ko
authors: CK
authors: Yeh
authors: Michael
authors: M
authors: Dodds
authors: Erhard
authors: E
authors: Haus
authors: Erwin
authors: E
authors: Schaffer
authors: Mikhail
authors: M
authors: Blank
authors: Franz
authors: F
authors: Halberg
mesh_terms: D000818:Animals; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry / Q000378:metabolism*; D017763:Autonomic Denervation; D014408:Biomarkers, Tumor / Q000276:immunology; D002417:Cattle; D004032:Diet; D006801:Humans; D010306:Parotid Gland / Q000294:innervation / Q000378:metabolism* / Q000601:surgery; D051381:Rats; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; C083823:CA-130 antigen