[Application of Ethyol during chemotherapy in patients with impaired kidney function. Description of three cases].
Nephrotoxicity is observed in 30% of patient's treated with chemotherapy schedules based on cisplatin analogues. Ethyol (amiphostin) was used as a protectant of kidney in 3 paediatric patients with neoplastic disease. Two patients suffered from Wilms tumour. One of them, a 5 month old boy presented with agenesis of the right kidney and stage II tumour in the left kidney. Bilateral Wilms tumour was recognised in a 6 year old girl. In both cases glomerular filtration was diminished. The third patient was a girl aged 5 who had isolated relapse of neuroblastoma in the central nervous system. Primary treatment caused nephrotoxic complications such as Fanconi syndrome and diminished glomerular filtration (66 ml/min). In these 3 cases Ethyol was used every lime before analogues of cisplatin were given. Tolerance and the effect of this protectant were good.
Drozynska
E
E
Klinika Pediatrii, Hematologii, Onkologii i Endokrynologii, Akademia Medyczna, Debinki 7, 80-211 Gdansk, Poland.
Stefanowicz
J
J
Polczynska
K
K
Balcerska
A
A
Czauderna
P
P
D004999:Amifostine / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D016543:Central Nervous System Neoplasms / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000139:chemically induced* / Q000503:physiopathology; D007680:Kidney Neoplasms / Q000188:drug therapy; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D016896:Treatment Outcome; D009396:Wilms Tumor / Q000188:drug therapy
D011837:Radiation-Protective Agents; D004999:Amifostine