Nuclear hormone receptors in T lymphocytes.
Among the numerous steroid and orphan nuclear receptors encoded within mammalian genomes, several are involved in regulating immune system functions. We review here recent studies on the glucocorticoid receptor and the orphan receptors Nur77 and RORgamma. These molecules play key roles in the development and the effector functions of T lymphocytes.
Winoto
Astar
A
Department of Molecular and Cell Biology, 469 LSA, University of California, Berkeley, Berkeley, CA 94720, USA. winoto@uclink4.berkeley.edu
Littman
Dan R
DR
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D018168:Receptors, Retinoic Acid; D011987:Receptors, Steroid; D011988:Receptors, Thyroid Hormone; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
D004268:DNA-Binding Proteins; C539821:NR4A1 protein, human; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; C539900:RORC protein, human; D018160:Receptors, Cytoplasmic and Nuclear; D011965:Receptors, Glucocorticoid; D018168:Receptors, Retinoic Acid; D011987:Receptors, Steroid; D011988:Receptors, Thyroid Hormone; D014157:Transcription Factors