The pathology of primary progressive multiple sclerosis.
The present review will focus on the current knowledge of the pathology of primary progressive multiple sclerosis lesions. Multiple sclerosis (MS) is an inflammatory demyelinating disease with a broad clinical variability. The main disease courses are relapsing-remitting, secondary progressive and primary progressive MS. Pathological studies examining the specific underlying pathology of a defined clinical subtype are rare. Here, we focus on the pathological characteristics of the MS lesions and summarize the current findings of the pathology of primary progressive MS with respect to inflammation, oligodendrocyte myelin pathology, axon destruction and immunopathology of the lesions.
Brück
W
W
Department of Neuropathology, Charitè, Berlin, Germany. wolfgang.brueck@charite.de
Lucchinetti
C
C
Lassmann
H
H
D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics; D017209:Apoptosis; D001369:Axons / Q000648:ultrastructure; D002490:Central Nervous System / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation; D016131:Lymphocyte Subsets / Q000276:immunology / Q000473:pathology; D020528:Multiple Sclerosis, Chronic Progressive / Q000235:genetics / Q000473:pathology*; D009186:Myelin Sheath / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000235:genetics; D009836:Oligodendroglia / Q000473:pathology
D001057:Apolipoproteins E; D009419:Nerve Tissue Proteins