title: Academic and cognitive abilities in children of parents with bipolar disorder: a test of the nonverbal learning disability model.
abstract: It has been hypothesized that children who are at genetic risk to develop bipolar disorder demonstrate deficiencies consistent with the syndrome of nonverbal learning disabilities (NLD); however, this hypothesis has never been tested directly. In the present study, a group of at-risk children (AR group; N = 28) was compared to a demographically matched control group of children of healthy parents (HC group; N = 24) for evidence of a constellation of features associated with NLD. Some characteristic features of NLD were evident, including significant Verbal IQ (VIQ) > Performance IQ (PIQ) discrepancies and psychomotor deficits. However, academic deficiencies in mechanical arithmetic relative to reading and spelling abilities were not demonstrated. These findings replicate and extend the current literature on the cognitive functioning of children of parents with Bipolar disorder (BPD). The results, however, do not support the presence of NLD in these children.
authors: Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH, USA. RYAQ43@chmcc.org
authors: Patricia
authors: P
authors: McDonough-Ryan
authors: Melissa
authors: M
authors: DelBello
authors: Paula K
authors: PK
authors: Shear
authors: Douglas M
authors: DM
authors: Ris
authors: Ceasar
authors: C
authors: Soutullo
authors: Stephen M
authors: SM
authors: Strakowski
mesh_terms: D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D002648:Child; D016241:Child of Impaired Parents / Q000523:psychology*; D004522:Educational Status; D005260:Female; D020022:Genetic Predisposition to Disease / Q000523:psychology; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D007859:Learning Disabilities / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D008297:Male; D008433:Mathematics; D011596:Psychomotor Disorders / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D011932:Reading; D012307:Risk Factors; D014706:Verbal Learning