An invitation to T and more: notch signaling in lymphopoiesis.
Cell fate decisions in metazoans are regulated by Notch signals. During lymphoid development, Notch influences a series of cell fate decisions involving multipotent progenitors. This review focuses on current views and lingering uncertainties about Notch function in lymphoid cells.
Allman
David
D
Department of Pathology and Laboratory Medicine, The Abramson Family Cancer Research Institute, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
Punt
Jennifer A
JA
Izon
David J
DJ
Aster
Jon C
JC
Pear
Warren S
WS
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D006410:Hematopoiesis; D006801:Humans; D007938:Leukemia / Q000378:metabolism; D008214:Lymphocytes / Q000166:cytology* / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D051880:Receptors, Notch; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
D008565:Membrane Proteins; D051880:Receptors, Notch