title: Diversity of rotavirus strains among children with acute diarrhea in China: 1998-2000 surveillance study.
abstract: As part of a national rotavirus surveillance activity, we collected fecal specimens from 3,177 children with acute diarrhea in 10 regions of China between April 1998 and April 2000 and screened them for rotavirus. Rotavirus was detected in 41% (n = 1,305) of specimens, and in these, G1 was the predominant serotype (72.6%), followed by G3 (14.2%), G2 (12.1%), G4 (2.5%), G9 (0.9%), and G untypeable (0.7%). Among 327 G-typed strains tested for P genotype, 14 different P-G combinations were identified, with the globally common strains P[8]G1, P[4]G2, P[8]G3, and P[8]G4 representing 75.6% of all typed rotavirus strains. Among the uncommon strains, 11 were P[6]G9, and others included P[6]G1, P[6]G3, and five novel P-G combinations (P[9]G1, P[4]G1, P[4]G3, P[4]G4, and P[8]G2). Our results indicate that while the common rotavirus strains remain predominant, the diversity of strains is much greater than was previously recognized.
authors: Division of Enteric Viruses, Institute of Virology, Chinese Academy of Preventive Medicine, 100 Ying Xin Jie, Xuan Wu Qu, Beijing 100052, People's Republic of China. fangzhyn@263.net
authors: Zhao-Yin
authors: ZY
authors: Fang
authors: Hui
authors: H
authors: Yang
authors: Jin
authors: J
authors: Qi
authors: Jing
authors: J
authors: Zhang
authors: Li-Wei
authors: LW
authors: Sun
authors: Jing-Yu
authors: JY
authors: Tang
authors: Li
authors: L
authors: Ma
authors: Zeng-Qing
authors: ZQ
authors: Du
authors: Ai-Hua
authors: AH
authors: He
authors: Jian-Ping
authors: JP
authors: Xie
authors: Yi-Yu
authors: YY
authors: Lu
authors: Zhen-Zhou
authors: ZZ
authors: Ji
authors: Bao-Quan
authors: BQ
authors: Zhu
authors: Hai-Yan
authors: HY
authors: Wu
authors: Si-En
authors: SE
authors: Lin
authors: Hua-Ping
authors: HP
authors: Xie
authors: Dixie D
authors: DD
authors: Griffin
authors: Bernard
authors: B
authors: Ivanoff
authors: Roger I
authors: RI
authors: Glass
authors: Jon R
authors: JR
authors: Gentsch
mesh_terms: D000208:Acute Disease; D002648:Child; D002681:China / Q000453:epidemiology; D003967:Diarrhea / Q000453:epidemiology* / Q000821:virology; D005838:Genotype; D005843:Geography; D006801:Humans; D015994:Incidence; D011159:Population Surveillance; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012401:Rotavirus / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000453:epidemiology*