Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
A number of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives, containing the adamantyl moiety, were synthesized and examined in various viral test systems. No antiviral effects were noted with any of the compounds at subtoxic concentrations in cell culture.
Kritsanida
Marina
M
Department of Pharmacy, University of Athens, Greece.
Mouroutsou
Anastasia
A
Marakos
Panagiotis
P
Pouli
Nicole
N
Papakonstantinou-Garoufalias
Spyroula
S
Pannecouque
Christophe
C
Witvrouw
Myriam
M
De Clercq
Erik
E
D000218:Adamantane / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D002522:Chlorocebus aethiops; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013601:T-Lymphocytes / Q000187:drug effects / Q000821:virology; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D014709:Vero Cells; D015215:Zidovudine / Q000494:pharmacology / Q000633:toxicity
D019380:Anti-HIV Agents; D000998:Antiviral Agents; D013830:Thiadiazoles; D014230:Triazoles; D015215:Zidovudine; D000218:Adamantane