Anthelmintic activity of preparations derived from Myrsine africana and Rapanea melanophloeos against the nematode parasite, Haemonchus contortus, of sheep.
Myrsine africana L. and Rapanea melanophloeos L. belong to the plant family Myrsinaceae. Various rural communities in Kenya, such as smallholder farmers and pastoralists, use them to treat their livestock. The anthelmintic effects/activities of leaves and fruits of M. africana and fruits of R. melanophloeos were tested in sheep experimentally infected with the nematode parasite Haemonchus contortus. Male lambs were infected with 3000-5000 third stage larvae of H. contortus and treated 28 days after inoculation with concoctions made from leaves or fruits of the plants. No significant reduction in faecal nematode egg counts was observed with any of the concoctions at any of the doses tested. Packed red cell volume decreased and live weight increased at similar rates in treated and control groups, thus there was no significant effect of treatment. The results showed that the tested extracts of the M. africana and R. melanophloeos were not efficacious against H. contortus in sheep.
Githiori
John B
JB
International Livestock Research Institute (ILRI), PO Box 30709, Nairobi, Kenya. j.githiori@cgiar.org
Höglund
Johan
J
Waller
Peter J
PJ
Baker
R Leyden
RL
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D006188:Haemonchiasis / Q000188:drug therapy*; D006189:Haemonchus / Q000187:drug effects*; D008297:Male; D010270:Parasite Egg Count; D008517:Phytotherapy; D029623:Primulaceae; D012756:Sheep
D000871:Anthelmintics