title: A trypanocidal phenazine derived from beta-lapachone.
abstract: An intensive effort has been directed toward finding alternative drugs for treatment of Chagas' disease, caused by Trypanosoma cruzi, and prophylaxis of blood in endemic areas. Our research comprises the synthesis and trypanocidal screening of derivatives from naphthoquinones. Herein a new phenazine, obtained from the reaction of beta-lapachone with aniline, has its structure established by physical data and X-ray analysis. It was 9 times more active against T. cruzi trypomastigotes than crystal violet.
authors: Núcleo de Pesquisas em Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, 21944-970 Rio de Janeiro, RJ, Brazil.
authors: Cleverson
authors: C
authors: Neves-Pinto
authors: Valéria R S
authors: VR
authors: Malta
authors: Maria do Carmo F R
authors: Mdo C
authors: Pinto
authors: Regina H A
authors: RH
authors: Santos
authors: Solange L
authors: SL
authors: de Castro
authors: Antônio Ventura
authors: AV
authors: Pinto
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry; D000818:Animals; D018360:Crystallography, X-Ray; D010619:Phenazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: C455283:7,8-dihydro-2,2-dimethyl-6-(N-phenyl)-3-(N-phenylamino)-4-(N-phenylimino)-4H,6H,7H-benzo(a)pyran(2,3-c)phenazine; D000814:Aniline Compounds; D010619:Phenazines; D014344:Trypanocidal Agents; C023650:aniline