The problem of functional localization in the human brain.
Functional imaging gives us increasingly detailed information about the location of brain activity. To use this information, we need a clear conception of the meaning of location data. Here, we review methods for reporting location in functional imaging and discuss the problems that arise from the great variability in brain anatomy between individuals. These problems cause uncertainty in localization, which limits the effective resolution of functional imaging, especially for brain areas involved in higher cognitive function.
Brett
Matthew
M
MRC Cognition and Brain Sciences Unit, Cambridge, UK. matthew.brett@mrc-cbu.cam.ac.uk
Johnsrude
Ingrid S
IS
Owen
Adrian M
AM
D001921:Brain / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology*; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods*; D014644:Genetic Variation / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D015201:Meta-Analysis as Topic; D015588:Observer Variation; D015203:Reproducibility of Results; D014055:Tomography, Emission-Computed / Q000295:instrumentation / Q000379:methods