title: Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome.
abstract: Two cases of reversible posterior leukoencephalopathy syndrome were examined with proton MR spectroscopic imaging. Widespread metabolic abnormalities, consisting of increased choline and creatine levels and mildly decreased N-acetylaspartate, occurred in regions with both normal and abnormal MR imaging appearances. In one case for which proton MR spectroscopic imaging follow-up was available, all metabolite levels had returned to normal by 2 months. Proton MR spectroscopic imaging may be helpful for the diagnosis and investigation of the underlying pathophysiology of reversible posterior leukoencephalopathy syndrome.
authors: Department of Neurogenetics, The Johns Hopkins University, Baltimore, MD, USA.
authors: Florian S
authors: FS
authors: Eichler
authors: Paul
authors: P
authors: Wang
authors: Robert J
authors: RJ
authors: Wityk
authors: Norman J
authors: NJ
authors: Beauchamp
authors: Peter B
authors: PB
authors: Barker
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001927:Brain Diseases / Q000175:diagnosis / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D003221:Confusion / Q000175:diagnosis / Q000378:metabolism*; D003401:Creatine / Q000378:metabolism; D005260:Female; D006261:Headache / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000378:metabolism; D012640:Seizures / Q000175:diagnosis / Q000378:metabolism*; D013577:Syndrome; D014018:Tissue Distribution; D014786:Vision Disorders / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline