T-cell prolymphocytic leukemia with hemorrhagic gastrointestinal involvement and a new chromosomal abnormality.
We report a case of T-cell prolymphocytic leukemia in a 56-year-old woman who exhibited hemorrhaging with gastric involvement as the first manifestation. This patient's condition was diagnosed as T-cell prolymphocytic leukemia based on the findings of lymphocytosis, abnormal immunophenotype, hepatosplenomegaly, lymphadenopathy, and cutaneous involvement. Endoscopic examination of the upper gastrointestinal tract revealed hemorrhage from a gastric lesion with histological involvement. Cytogenetic analysis revealed chromosomal abnormalities, 46,XX,der(1), add(1)(p36), that have not previously been described in T-cell prolymphocytic leukemia. In spite of a transient response to chemotherapy, the patient died 15 months after onset of the disease.
Toyota
Shigeo
S
Department of Internal Medicine, Yokosuka Kyousai Hospital, Kanagawa, Japan.
Nakamura
Norihiko
N
Dan
Kazuo
K
D015703:Antigens, CD / Q000097:blood; D002869:Chromosome Aberrations; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000150:complications* / Q000235:genetics / Q000473:pathology; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015463:Leukemia, Prolymphocytic / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000473:pathology; D015458:Leukemia, T-Cell / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D014960:X Chromosome
D015703:Antigens, CD