Perioperative hemodynamic and geometric changes of the left ventricle during cardiomyoplasty in goats with dilated left ventricle.
OBJECTIVE
Clinical data have suggested the occurrence of temporary short-term deterioration of the heart following cardiomyoplasty. The purpose of this study was to monitor the short-term hemodynamic effects of cardiomyoplasty in a goat model of a dilated left ventricle, using conductance catheters (ie, pressure-volume loops) and cardiac output measurements.


METHODS
Eight female goats underwent acute cardiomyoplasty 8 to 12 weeks after left ventricular (LV) dilatation was induced by a carotid jugular arteriovenous shunt. The cardiomyoplasty procedure was monitored using a Swan-Ganz catheter for cardiac output measurements and a 12-electrode (dual-field) conductance catheter to LV pressure-volume loops.


RESULTS
After wrapping the heart with the latissimus dorsi muscle, there was a significant reduction in both cardiac output and LV end-diastolic volume (LVEDV) at 10 min. Partial recovery was observed 45 min later.


CONCLUSIONS
A decrease in both cardiac output and LVEDV was observed following myocardial wrapping. This may explain some of the perioperative and postoperative morbidity and mortality observed following cardiomyoplasty.
Bolotin
Gil
G
Department of Cardiothoracic Surgery, Tel Aviv Sourasky Medical Center, Division of Cardiac Surgery, Tel Aviv, Israel. bolotin@netvision.net.il
Lorusso
Roberto
R
Schreuder
Jan J
JJ
Nesher
Nahum
N
Kaulbach
Hans
H
Uretzky
Gideon
G
van der Veen
Frederick
F
D000818:Animals; D002302:Cardiac Output; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology* / Q000601:surgery; D018421:Cardiomyoplasty; D005260:Female; D006041:Goats; D006439:Hemodynamics; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology / Q000601:surgery; D013318:Stroke Volume; D016277:Ventricular Function, Left