title: Clinical and histological spectrum of elastotic changes induced by penicillamine.
abstract: A 79-year-old-man with cystinuria requiring long-term penicillamine therapy presented with a 6-month history of itchy annular lesions in both axillae. Clinical examination revealed lesions consisting of crusted keratotic papules coalescing in an annular distribution. Associated findings included generalized skin laxity accentuated on the upper trunk and arms, as well as small yellowish papules on the neck. Histological evaluation revealed short, thick, eosinophilic elastic fibres with nodular protrusions. Transepidermal elimination of abnormal elastic fibres was also evident. We discuss the histological and clinical spectrum of penicillamine-induced elastotic changes and compare these changes to those seen in primary elastotic disorders.
authors: Austin and Repatriation Medical Centre Melbourne, Victoria, Australia. epoon@ausdoctors.net
authors: Eric
authors: E
authors: Poon
authors: Graham H
authors: GH
authors: Mason
authors: Chris
authors: C
authors: Oh
mesh_terms: D000368:Aged; D002614:Chelating Agents / Q000009:adverse effects*; D003483:Cutis Laxa / Q000139:chemically induced* / Q000473:pathology; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000009:adverse effects*; D012867:Skin / Q000473:pathology
chemical_list: D002614:Chelating Agents; D010396:Penicillamine