The 3' 5' exonucleases.
Over the past few years, several new 3' 5' exonucleases have been identified. In vitro studies of these enzymes have uncovered much about their potential functions in vivo, and certain organisms with a defect in 3' 5' exonucleases have an increased susceptibility to cancer, especially under conditions of stress. Here, we look at not only the newly discovered enzymes, but also at the roles of other 3' 5' exonucleases in the quality control of DNA synthesis, where they act as proofreading exonucleases for DNA polymerases during DNA replication, repair and recombination.
Shevelev
Igor V
IV
Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Hübscher
Ulrich
U
D000595:Amino Acid Sequence; D000818:Animals; D004265:DNA Helicases / Q000502:physiology; D004258:DNA Polymerase III / Q000502:physiology; D004260:DNA Repair / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D043211:Exodeoxyribonuclease V; D005090:Exodeoxyribonucleases / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D010750:Phosphoproteins; D017434:Protein Structure, Tertiary; D053484:RecQ Helicases; D011995:Recombination, Genetic; D016415:Sequence Alignment; D000071657:Werner Syndrome Helicase
D010750:Phosphoproteins; D004258:DNA Polymerase III; D005090:Exodeoxyribonucleases; D043211:Exodeoxyribonuclease V; C429526:three prime repair exonuclease 1; D004265:DNA Helicases; D053484:RecQ Helicases; C098785:WRN protein, human; D000071657:Werner Syndrome Helicase