Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis.
We examined the effect of an inhibitor of secretory phospholipase A2 type II (LY311727) and of a specific inhibitor of serine proteases (AEBSF) in a murine model of acute toxoplasmosis. LY311727 did not afford any significant protection and produced earlier mortality compared with untreated mice at a dose of 100 mg/kg. In contrast, AEBSF demonstrated a significant increase in length of survival, and this effect was enhanced when AEBSF was administered with non-protective doses of pyrimethamine.
Buitrago-Rey
Rafael
R
Facultad de Medicina, Universidad Nacional de Colombia, Armenia (Q), Colombia.
Olarte
Jorge
J
Gomez-Marin
Jorge Enrique
JE
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D007211:Indoles / Q000627:therapeutic use*; D051379:Mice; D008813:Mice, Inbred ICR; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D054467:Phospholipases A2; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000627:therapeutic use*; D016019:Survival Analysis; D014122:Toxoplasma; D014123:Toxoplasmosis / Q000188:drug therapy* / Q000382:microbiology
D000890:Anti-Infective Agents; D007211:Indoles; C095553:LY 311727; D013450:Sulfones; C002010:4-(2-aminoethyl)benzenesulfonylfluoride; D010741:Phospholipases A; D054467:Phospholipases A2