Photochromic nucleic base units suitable for nucleic acid labelling.
New molecules incorporating a uracil nucleic base and a dihydroindolizine (DHI) unit linked via spacer arms, i.e., uracil-spyrodihydroindolizine (4), were synthesised as models for light sensitive systems for nucleic acid labelling. The uracil-DHI (4) undergoes easy photocoloration to the uracil-betaine (5) generating the UV-detectable species. Preliminary results show rather weak binding of uracil-DHI (4) to calf thymus-DNA.
Gogritchiani
Eliso
E
Universität des Saarlandes, Fakultät 8.12, Organische Chemie, Im Stadtwald, D-66123, Saarbrücken, Germany.
Hartmann
Thomas
T
Palm
Barbara Susanne
BS
Samsoniya
Shota
S
Dürr
Heinz
H
D000818:Animals; D001622:Betaine / Q000737:chemistry; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D007212:Indolizines / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000737:chemistry*; D013950:Thymus Gland / Q000737:chemistry*; D014498:Uracil / Q000031:analogs & derivatives / Q000737:chemistry*
D007212:Indolizines; D017319:Photosensitizing Agents; C467358:uracil-spyrodihydroindolizine; D001622:Betaine; D014498:Uracil; D004247:DNA