title: Pattern of sensitization to common environmental allergens amongst atopic Singapore children in the first 3 years of life.
abstract: This study was aimed to investigate the sensitization pattern to a range of common allergens in young Singaporean children. A cross-sectional study involving 75 children aged below 3 years was carried out. They presented between December 1995 and April 2000 with symptoms of asthma, rhinitis, eczema, or food allergy. Their levels of allergen-specific serum IgE to a panel of foods (egg white, milk, soy protein, shrimp, wheat and peanut), pet dander, dust mites and cockroaches were measured with Pharmacia CAP System radioallergosorbent test kits. Serum IgE levels greater than 0.35 kU/l represented a positive result. Four children could not be tested with the complete panel because of insufficient serum. The prevalence of sensitization was highest for cow's milk (45.9%) followed by egg white (38.7%), dust mites Dermatophagoides pteronyssinus (31.4%) and Blomia tropicalis (25.5%). Sensitization to ingested allergens was significantly more prevalent in children aged 1 year or younger than in the older children (70.4% of those below 1 year, and 50% of those aged 1-3 years; p < 0.02). Sensitization to inhaled allergens, such as dust mites, was more likely to manifest as respiratory symptoms (allergic rhinitis and asthma), while ingested allergens were associated with gastrointestinal symptoms and eczema (p < 0.001). It was concluded that infants and young children are at high risk of sensitization to common environmental substances. Allergen avoidance is therefore important even in the very young. The prevalence of sensitization to food allergens is higher compared to inhalant allergens in young children.
authors: Department of Paediatrics, National University of Singapore, Singapore.
authors: J
authors: J
authors: Khoo
authors: L P
authors: LP
authors: Shek
authors: L
authors: L
authors: Shek
authors: E S
authors: ES
authors: Khor
authors: D Y
authors: DY
authors: Wang
authors: B W
authors: BW
authors: Lee
mesh_terms: D000485:Allergens / Q000032:analysis / Q000276:immunology*; D000818:Animals; D002675:Child, Preschool; D003058:Cockroaches / Q000276:immunology; D004391:Dust / Q000276:immunology; D004781:Environmental Exposure; D005512:Food Hypersensitivity / Q000209:etiology / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008892:Milk / Q000276:immunology; D008925:Mites / Q000276:immunology; D011852:Radioallergosorbent Test; D012130:Respiratory Hypersensitivity / Q000209:etiology / Q000276:immunology / Q000503:physiopathology; D012846:Singapore
chemical_list: D000485:Allergens; D004391:Dust; D007073:Immunoglobulin E