title: Radical scavenging activities of niacin-related compounds.
abstract: We investigated whether niacin-related compounds had radical-scavenging activity by electron spin resonance methods. Many compounds, but not trigonelline, had radical-scavenging activity against hydroxyl radicals. However, for the nitric oxide radical and 1,1-diphenyl-2-picrylhydrazyl radical, only nicotinic acid hydrazide and isonicotinic acid hydrazide had scavenging activities. These results suggest that the moiety of hydrazide might have an important role in scavenging abilities of various radicals.
authors: Department of Life Science, Faculty of Bioresources, Mie University, Tsu, Japan.
authors: Shin
authors: S
authors: Ogata
authors: Masayo
authors: M
authors: Takeuchi
authors: Shin
authors: S
authors: Teradaira
authors: Naokuni
authors: N
authors: Yamamoto
authors: Keiko
authors: K
authors: Iwata
authors: Katsuzumi
authors: K
authors: Okumura
authors: Hiroshi
authors: H
authors: Taguchi
mesh_terms: D001713:Biphenyl Compounds; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000737:chemistry*; D005609:Free Radicals; D017665:Hydroxyl Radical / Q000737:chemistry; D009525:Niacin / Q000031:analogs & derivatives* / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry; D016877:Oxidants / Q000737:chemistry; D010851:Picrates / Q000737:chemistry; D017382:Reactive Oxygen Species
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D005609:Free Radicals; D016877:Oxidants; D010851:Picrates; D017382:Reactive Oxygen Species; D009525:Niacin; D009569:Nitric Oxide; D017665:Hydroxyl Radical; C004931:1,1-diphenyl-2-picrylhydrazyl