title: Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
abstract: A number of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives, containing the adamantyl moiety, were synthesized and examined in various viral test systems. No antiviral effects were noted with any of the compounds at subtoxic concentrations in cell culture.
authors: Department of Pharmacy, University of Athens, Greece.
authors: Marina
authors: M
authors: Kritsanida
authors: Anastasia
authors: A
authors: Mouroutsou
authors: Panagiotis
authors: P
authors: Marakos
authors: Nicole
authors: N
authors: Pouli
authors: Spyroula
authors: S
authors: Papakonstantinou-Garoufalias
authors: Christophe
authors: C
authors: Pannecouque
authors: Myriam
authors: M
authors: Witvrouw
authors: Erik
authors: E
authors: De Clercq
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D002522:Chlorocebus aethiops; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013601:T-Lymphocytes / Q000187:drug effects / Q000821:virology; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D014709:Vero Cells; D015215:Zidovudine / Q000494:pharmacology / Q000633:toxicity
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents; D013830:Thiadiazoles; D014230:Triazoles; D015215:Zidovudine; D000218:Adamantane