title: Effects of zopiclone on blood glucose level, serum lipid concentration and clot lysis time in normoglycemic and normolipidemic rats.
abstract: In normoglycemic and normolipidemic rats the i.p. injection of zopiclone induced an acceleration of fibrinolysis in a dose-dependent bell shaped manner and various changes of the blood glucose level. Total lipids, total cholesterol and triglyceride serum levels remained unaffected by doses of 1.25, 2.5 and 15.0 mg/kg, with the exception of the medium dose (5.0 mg/kg) and the next dose (10.0 mg/kg) which lowered them very significantly.
authors: Department of Pharmacology, Faculty of Medicine and Pharmacy, University of Oradea, Cluj Napoca, Romania.
authors: J
authors: J
authors: Horák
authors: B
authors: B
authors: Cuparencu
authors: A
authors: A
authors: Horák
mesh_terms: D000818:Animals; D053961:Azabicyclo Compounds; D001786:Blood Glucose / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D011345:Fenofibrate / Q000494:pharmacology; D005342:Fibrinolysis / Q000187:drug effects*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008055:Lipids / Q000097:blood*; D008297:Male; D009994:Osmolar Concentration; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013997:Time Factors
chemical_list: D053961:Azabicyclo Compounds; D001786:Blood Glucose; D006993:Hypnotics and Sedatives; D000960:Hypolipidemic Agents; D008055:Lipids; D010879:Piperazines; C515050:zopiclone; D011345:Fenofibrate