ABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillus.
BACKGROUND
Epidemiological studies have demonstrated higher frequencies of the O blood group and the non-secretor phenotype of ABH antigens among patients suffering from peptic ulcers. Since Helicobacter pylori has been established as the main etiological factor in this disease, controversies about the associations of the ABO and Lewis blood group phenotypes and secretor and non-secretor phenotypes in relation to susceptibility towards infection by this bacillus have been presented.


OBJECTIVE
To verify the frequencies of ABO, Lewis blood group phenotypes, secretor and non-secretor phenotypes in patients infected or uninfected by H. pylori.


METHODS
Cross-sectional study.


METHODS
Outpatient clinic.


METHODS
One hundred and twenty patients with dyspeptic symptoms who underwent endoscopy.


METHODS
ABO and Lewis blood group phenotypes were determined by a standard hemagglutination test and the secretor and non-secretor phenotypes were evaluated by saliva samples using the inhibitor hemagglutination test.


RESULTS
The diagnosis of infection, made via breath and urea tests and confirmed using polymerase chain reaction (PCR) in gastric biopsy fragments, showed the presence of H. pylori in 61.7% of the patients and absence in 38.3%. The differences between the frequencies of the ABO blood group phenotypes among infected (A 27.0%; B 12.2%; AB 4.0% and O 56.8%) and uninfected patients (A 58.7%; B 13.0%; AB 4.3% and O 24.0%) were significant. The Lewis blood type, secretor and non-secretor phenotypes showed homogeneous distribution between the groups of patients analyzed.


CONCLUSIONS
Our results suggest that the infection of H. pylori can be related to ABO blood groups but not to the Lewis blood group nor to secretor and non-secretor phenotypes.
de Mattos
Luiz Carlos
LC
Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto, Brazil. lumattos@famerp.br
Rodrigues Cintra
Juliana
J
Sanches
Fábio Eduardo
FE
Alves da Silva
Rita de Cássia Martins
Rde C
Ruiz
Milton Artur
MA
Moreira
Haroldo Wilson
HW
D000017:ABO Blood-Group System / Q000032:analysis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D004415:Dyspepsia / Q000097:blood* / Q000382:microbiology; D005260:Female; D016481:Helicobacter Infections / Q000097:blood* / Q000150:complications; D016480:Helicobacter pylori; D006386:Hemagglutination Tests; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000032:analysis*; D008297:Male; D010641:Phenotype; D016133:Polymerase Chain Reaction
D000017:ABO Blood-Group System; D007983:Lewis Blood Group Antigens