NMR analysis of quinocycline antibiotics: structure determination of kosinostatin, an antitumor substance from Micromonospora sp. TP-A0468.
A quinocycline antibiotic, kosinostatin, was isolated from the culture broth of Micromonospora sp. TP-A0468 along with isoquinocycline B. Structure of kosinostatin was determined to be the stereoisomer of isoquinocycline B regarding to the stereochemistry at the C-2' spiro carbon by NMR analysis. Kosinostatin isomerizes to isoquinocycline B through the inversion of the stereocenter at C-2'. Comparison of physico-chemical properties indicated that kosinostatin is presumably identical with quinocycline B isolated by CELMER et al. from Streptomyces aureofaciens.
Igarashi
Yasuhiro
Y
Biotechnology Research Center, Toyama Prefectural University Kosugi, Japan. yas@pu-toyama.ac.jp
Higuchi
Hiroko
H
Oki
Toshikazu
T
Furumai
Tamotsu
T
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C455260:kosinostatin