Interactions of intercellular adhesion molecule-1 with fibrinogen.
The binding of plasma protein fibrinogen (Fg) to intercellular adhesion molecule-1 (ICAM-1) on endothelial cells mediates the attachment of leukocytes and platelets that may result in vascular occlusion. Fg:ICAM-1 interactions elicit an array of effects that could have implications in vascular pathology and inflammation. ICAM-1 expression is regulated during inflammation and upon Fg binding. The mechanistic model presented provides a framework to delineate the consequences of Fg binding to ICAM-1.
Tsakadze
Nina L
NL
Department of Physiology & Biophysics, University of Louisville, Louisville, KY 40292, USA.
Zhao
Zhendong
Z
D'Souza
Stanley E
SE
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D005340:Fibrinogen / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D010766:Phosphorylation; D011485:Protein Binding; D015398:Signal Transduction
D018799:Intercellular Adhesion Molecule-1; D005340:Fibrinogen