Exendin-4, a GLP-1 receptor agonist, modulates the effect of macronutrients on food intake by rats.
The hypothesis that peripheral GLP-1 modulates the effect of macronutrients on food intake in rats was tested by administration of its agonist, exendin-4. The effect of exendin-4 on food intake suppression and blood glucose after carbohydrate, fat and protein preloads was measured. Exendin-4 reduced the effect of glucose preloads on food intake only during the first 30 min (P = 0.01) of feeding, but had a more prolonged effect when given with corn oil (P < 0.01 at 0-0.5 h and 0-1 h, P = 0.055 at 0-2 h, and P = 0.07 at 0-3 h) and whey (P < 0.05 at 0-1 h, P = 0.06 at 0-2 h, and P = 0.07 at 0-3 h) preloads. Blood glucose measured over 2 h was reduced at 15 min when given with glucose (P < 0.01), unchanged when given with corn oil and increased at 60 and 120 min when given with whey (P < 0.01). Thus, the effect of exendin-4 on the feeding response depended on the composition of the macronutrient preloads and seems to be independent of blood glucose concentrations.
Aziz
Alfred
A
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2.
Anderson
G Harvey
GH
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000378:metabolism; D002149:Energy Intake / Q000187:drug effects* / Q000502:physiology; D000077270:Exenatide; D000067757:Glucagon-Like Peptide-1 Receptor; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018027:Receptors, Glucagon / Q000819:agonists* / Q000502:physiology; D013997:Time Factors; D014688:Venoms
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; C000593835:Glp1r protein, rat; D000067757:Glucagon-Like Peptide-1 Receptor; D010455:Peptides; D018027:Receptors, Glucagon; D014688:Venoms; D000077270:Exenatide