[Changes in hemodynamics with a combination of epidural anesthesia and propofol sedation in children].
Hemodynamic profiles and myocardial contractility were investigated in children aged 3-14 years during epidural anesthesia with propofol. Anesthesia was induced by intravenous bolus propofol (3.5 mg/kg). Ketamine (2.4 mg/kg) was used to potentiate analgesia during intubation. Xilocaine (5 mg/kg) was used for epidural analgesia. Anesthesia was maintained by continuous i.v. propofol infused in a dose of 191-312 micrograms/kg x min (mean dose 243 +/- 30.3 micrograms/kg x min) until the peak of epidural analgesic activity was reached, after which propofol dose was gradually reduced to 53-143 micrograms/kg x min (mean 108.8 +/- 14.6 micrograms/kg x min). This variant of epidural anesthesia with i.v. propofol ensured a hemodynamically stable anesthesia and good analgesia in operations of any complexity. It was however paralleled by a moderate decrease of myocardial contractility.
Agzamkhodzhaev
T S
TS
Tokhirov
Sh M
ShM
Kholmukhamedov
B M
BM
D000293:Adolescent; D000767:Anesthesia, Epidural; D002648:Child; D002675:Child, Preschool; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D007649:Ketamine / Q000008:administration & dosage; D008012:Lidocaine / Q000008:administration & dosage*; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*
D007649:Ketamine; D008012:Lidocaine; D015742:Propofol