title: CDC-25.1 regulates germline proliferation in Caenorhabditis elegans.
abstract: The cell cycles in C. elegans are tightly controlled but appear to use the same regulators found in other organisms. Four homologues of the dual-specificity phosphatase Cdc25 are present in the C. elegans genome. In our study, we have characterized a deletion mutant for one of these orthologues. We show that embryonic defects are absent in cdc-25.1 homozygous mutants, presumably because of maternally contributed CDC-25.1 product. These embryos hatch and develop into sterile adults. The adults do not appear to have any somatic defects. The sterility results from inadequate germline proliferation. Germline precursors divide slowly and produce abnormally sized daughter cells. Only three to four rounds of germ-cell division occur before they die during the L3 and L4 larval stages.
authors: Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, United Kingdom. N.Ashcroft@sussex.ac.uk
authors: Neville
authors: N
authors: Ashcroft
authors: Andy
authors: A
authors: Golden
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics / Q000378:metabolism*; D016923:Cell Death / Q000235:genetics; D005260:Female; D005854:Germ Cells / Q000254:growth & development*; D007246:Infertility / Q000235:genetics; D008297:Male; D009928:Organ Specificity; D017384:Sequence Deletion; D020687:cdc25 Phosphatases / Q000235:genetics / Q000378:metabolism*
chemical_list: D020687:cdc25 Phosphatases