Electron paramagnetic resonance of radicals induced in drugs and excipients by radiation or mechanical treatments.
Radiation as well as mechanical treatments induced in drugs and excipients radicals, which can be studied by electron paramagnetic resonance. A special attention is pointed about the use of electron paramagnetic resonance (EPR) to bring the proof whether or not a drug has been irradiated or not. We also discuss of other methods (thermoluminescence (TL), gas phase chromatography (GPC)) which can be used to bring the same proof in case of irradiated drugs, excipients and cosmetic products.
Raffi
J
J
LARQUA/LRMO, Faculté des Sciences de Saint-Jérĵme, Marseille, France. j.raffi@univ.u-3mrs.fr
Gelly
S
S
Barral
L
L
Burger
F
F
Piccerelle
P
P
Prinderre
P
P
Baron
M
M
Chamayou
A
A
D000596:Amino Acids; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002849:Chromatography, Gas; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005609:Free Radicals; D005720:Gamma Rays; D006358:Hot Temperature; D000069463:Olive Oil; D010938:Plant Oils / Q000494:pharmacology; D013696:Temperature; D014466:Ultraviolet Rays
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D005609:Free Radicals; D000069463:Olive Oil; D010938:Plant Oils; D000667:Ampicillin