title: Relationship between physical activity and oxidative stress biomarkers in women.
abstract: OBJECTIVE
  To examine the relationship between physical activity and levels of plasma lipid peroxides, superoxide dismutase in erythrocytes (SOD), and glutathione peroxidase (GSH-Px) in whole blood activities.
  
  
  METHODS
  Cross-sectional study in 488 Spanish women. Two categories of leisure time physical activity were defined according to their intensity: low (<or=6 METs) and high (>6 METs). Energy expenditure in household activities was also recorded. Multivariate linear regression analyses were used to adjust for the effect of physical activity on lipid peroxides and SOD and GSH-Px for confounding variables.
  
  
  RESULTS
  The amount of leisure time physical activity was associated with high activity levels of SOD (P = 0.022) and GSH-Px (P = 0.002). Similar results were obtained when physical activity in household activities was added to total leisure physical activity. Physical activity of low intensity was associated with high SOD activity levels (P = 0.002) and that of high intensity with high GSH-Px activity levels (P = 0.001).
  
  
  CONCLUSIONS
  The amount and intensity of leisure physical activity were directly related to both antioxidant enzyme activity levels. The findings of this study suggest a modulatory effect of leisure physical activity intensity on antioxidative balance in the studied female population.
authors: Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal de Investigació Mèdica, IMIM, Barcelona, Spain. mcovas@imim.es
authors: Maria-Isabel
authors: MI
authors: Covas
authors: Roberto
authors: R
authors: Elosua
authors: Montserrat
authors: M
authors: Fitó
authors: Mercedes
authors: M
authors: Alcántara
authors: Luis
authors: L
authors: Coca
authors: Jaume
authors: J
authors: Marrugat
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008019:Life Style; D008054:Lipid Peroxides / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D012907:Smoking; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D015415:Biomarkers; D008054:Lipid Peroxides; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase