title: Sex and the single (double-strand) break.
abstract: It has been known for some time that DNA double-strand breaks (DSBs) initiate homologous recombination during meiosis. Two recent studies show that the fate of a single DSB in yeast is strongly influenced by the presence of other breaks in the genome, hinting that cell-wide or chromosome-regional mechanisms control the outcome of DSB repair.
authors: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
authors: Emmanuelle
authors: E
authors: Martini
authors: Scott
authors: S
authors: Keeney
mesh_terms: D019457:Chromosome Breakage; D015825:Chromosomes, Fungal / Q000235:genetics* / Q000648:ultrastructure; D003434:Crossing Over, Genetic / Q000235:genetics; D004260:DNA Repair; D004271:DNA, Fungal / Q000235:genetics; D004706:Endodeoxyribonucleases / Q000502:physiology*; D004950:Esterases / Q000502:physiology; D008540:Meiosis / Q000235:genetics*; D008938:Mitosis / Q000235:genetics; D006180:Proton-Translocating ATPases; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*; D013573:Synaptonemal Complex / Q000502:physiology; D000099257:Meiotic Recombination Protein SPO11
chemical_list: D004271:DNA, Fungal; D004706:Endodeoxyribonucleases; D004950:Esterases; D006180:Proton-Translocating ATPases; D029701:Saccharomyces cerevisiae Proteins; D000099257:Meiotic Recombination Protein SPO11; C081687:VMA1 protein, S cerevisiae