title: Cytomegalovirus as a cause of anterior uveitis with sectoral iris atrophy.
abstract: OBJECTIVE
  To report two cases of recurrent anterior uveitis with sectoral iris atrophy and ocular hypertension during attacks caused by cytomegalovirus (CMV).
  
  
  METHODS
  Two observational case reports.
  
  
  METHODS
  Two immunocompetent patients with a history of recurrent unilateral hypertensive anterior uveitis with sectoral iris atrophy were referred to us with the presumptive diagnosis of herpetic uveitis.
  
  
  METHODS
  Comprehensive ophthalmic examination, aqueous humor polymerase chain reaction (PCR), and peripheral blood serologic studies were performed on both patients.
  
  
  RESULTS
  Examination of aqueous humor by PCR was positive for CMV and negative for herpesvirus. Serum IgG/IgM titers disclosed past CMV infection. Both patients responded well to antiviral therapy with ganciclovir. The final visual acuity level was 20/20 in both eyes of both patients.
  
  
  CONCLUSIONS
  CMV infection can produce recurrent attacks of anterior uveitis with clinical characteristics indistinguishable from those previously considered highly suggestive or even pathognomonic for herpetic infection. This observation has implications for the therapeutic management of such patients.
authors: Ocular Inflammation and Immunology Service, Department of Ophthalmology, General Hospital of Athens, Athens, Greece.
authors: Nikos N
authors: NN
authors: Markomichelakis
authors: Christina
authors: C
authors: Canakis
authors: Panayotis
authors: P
authors: Zafirakis
authors: Theodoros
authors: T
authors: Marakis
authors: Ioannis
authors: I
authors: Mallias
authors: George
authors: G
authors: Theodossiadis
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use; D001082:Aqueous Humor / Q000821:virology; D001284:Atrophy; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D015828:Eye Infections, Viral / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007498:Iris / Q000187:drug effects / Q000473:pathology* / Q000821:virology; D008297:Male; D009798:Ocular Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology; D016133:Polymerase Chain Reaction; D012008:Recurrence; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015774:Ganciclovir