Amphotericin B-induced hepatorenal failure in cystic fibrosis.
Although nephrotoxicity is a common and well-recognized side effect of amphotericin B, hepatotoxicity is rare. We report on a 9-year-old girl with cystic fibrosis who developed fulminant renal and hepatic dysfunction following a short course of intravenous amphotericin B for a suspected aspergillus infection, although she did not have clinical evidence of invasive aspergillosis. The toxicity became apparent after changing to liposomal amphotericin. This association of renal and hepatotoxicity with liposomal amphotericin B has not previously been reported in children.
Mohan
Uthara R
UR
Department of Respiratory Paediatrics, Royal Brompton Hospital, London, United Kingdom.
Bush
Andrew
A
D000563:Amebicides / Q000009:adverse effects* / Q000627:therapeutic use; D000666:Amphotericin B / Q000009:adverse effects* / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced* / Q000150:complications; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000150:complications
D000563:Amebicides; D000666:Amphotericin B