Drug-induced lung injury.
Lung injury is an increasing cause of morbidity and mortality in patients treated with cytotoxic and noncytotoxic drugs. Prompt diagnosis is important because early drug-induced lung injury will often regress with the cessation of therapy. Diagnosis requires a high index of suspicion because infection, radiation pneumonitis, and recurrence of the underlying disease can manifest clinically and radiologically in a similar manner. Because the lungs have only a limited number of histopathologic responses to injury, including pulmonary edema/diffuse alveolar damage, NSIP, BOOP, EP, and pulmonary hemorrhage, knowledge of these manifestations and the corresponding radiologic manifestations can often be useful in suggesting a diagnosis of drug-induced lung injury. An understanding of the drugs most commonly associated with lung injury can also facilitate diagnosis.
Erasmus
Jeremy J
JJ
Department of Radiology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
McAdams
H Page
HP
Rossi
Santiago E
SE
D000890:Anti-Infective Agents / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D002317:Cardiovascular Agents / Q000009:adverse effects; D018549:Cryptogenic Organizing Pneumonia / Q000139:chemically induced / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D006470:Hemorrhage / Q000139:chemically induced / Q000000981:diagnostic imaging; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000139:chemically induced / Q000000981:diagnostic imaging; D011654:Pulmonary Edema / Q000139:chemically induced / Q000000981:diagnostic imaging; D011657:Pulmonary Eosinophilia / Q000139:chemically induced / Q000000981:diagnostic imaging; D011859:Radiography
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D002317:Cardiovascular Agents