Angiotensin II type 1 receptor gene adenine/cytosine1166 polymorphism is not associated with mitral valve prolapse syndrome in Taiwan Chinese.
The adenine/cytosine1166 (A/C1166) polymorphism of the angiotensin-II type 1 receptor (AGTR1) gene is presumed to be associated with mitral valve prolapse syndrome (MVPS) in Caucasians. To investigate whether a similar association exists among the Chinese population in Taiwan, 100 patients with MVP diagnosed by echocardiography and 100 normal subjects were studied by polymerase chain reaction-based restriction analysis. The difference in genotype (chi2=0.24; p=0.89) and allelic (Yates' chi2=0.06; p=0.81) frequencies between the groups were not significant. Further categorization of the MVP patients into mild and severe subgroups also revealed no statistical difference from the controls. It was concluded that A/C1166 polymorphism of the AGTR1 gene is not a suitable genetic marker of MVPS in Taiwan Chinese.
Chou
Hsiang-Tai
HT
Department of Medicine, China Medical College Hospital, Taichung, Taiwan.
Shi
Yi-Ru
YR
Wu
Jer-Yuarn
JY
Tsai
Fuu-Jen
FJ
D000225:Adenine; D000328:Adult; D044466:Asian People; D003596:Cytosine; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008945:Mitral Valve Prolapse / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin / Q000235:genetics*; D013624:Taiwan; D044465:White People
D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin; D003596:Cytosine; D000225:Adenine