title: Classical cardiovascular risk factors in Trinidadian patients with type 2 diabetes mellitus are not influenced by the level of plasma glycaemia.
abstract: The aim of this study is to assess the plasma glycaemia of patients attending the diabetes mellitus outpatients' clinics in Trinidad and to determine how different plasma glycaemia would affect cardiovascular disease (CVD) risk factors. One hundred and ninety-one patients (64 males, 127 females, mean age 56.6 +/- 0.8 yr) with Type 2 diabetes mellitus (mean duration 9.2 +/- 0.6 yr) attending diabetes mellitus clinics from January to April 2000 participated in the study. Anthropometric indices (weight, height, waist and hip circumferences) and blood pressure were measured and overnight fasting blood samples were collected for glycated haemoglobin (HbA1c), glucose, lipids (triglyceride, total cholesterol, LDL-cholesterol, HDL-cholesterol) and creatinine determinations. The patients were categorized into Group 1 ('well controlled'; HbA1c < 7.0%) and Group 2 ('poorly controlled'; HbA1c > 7.0%). Although the majority (85%) of patients were poorly controlled', there were no significant differences in the age, duration of diabetes mellitus, body mass index and waist/hip ratios between the two groups of patients (p > 0.05). Similarly, the blood pressure and lipid (total cholesterol, HDL-cholesterol, LDL-cholesterol) levels did not differ between the two groups (p > 0.05) although triglyceride (1.4 +/- 0.1 vs. 2.2 +/- 0.1 mmol/L) levels were higher in patients in Group 2 compared with Group 1 (p < 0.05). Multiple linear regression analysis indicates that the levels of blood pressure, lipid and anthropometric parameters were not significantly dependent on the plasma glycaemia of the patients (p > 0.05). Analysis of the data has shown that the majority of patients with Type 2 diabetes mellitus attending primary care clinics in Trinidad had poor glycaemic control. The poorly controlled patients had similar levels of CVD risk factors to 'well controlled' patients although the former were potentially at greater risk of progressing to cardiovascular disorder than 'well controlled' patients.
authors: Department of Paraclinical Sciences, Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad and Tobago, West Indies. ezenwaka@tstt.net.tt
authors: C E
authors: CE
authors: Ezenwaka
authors: N V
authors: NV
authors: Offiah
mesh_terms: D001786:Blood Glucose; D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology*; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D016014:Linear Models; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014300:Trinidad and Tobago / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D002784:Cholesterol; D006442:Glycated Hemoglobin; D008055:Lipids; D014280:Triglycerides