Application of in silico positional cloning and bioinformatic mutation analysis to the study of eye diseases.
A vast amount of DNA and protein sequence is now available and a plethora of programs have been developed to analyse the data. The bewildering variety of analyses that can be performed via the World-Wide Web can deter researchers from applying bioinformatics to augment their traditional genetic research. Focusing on the inherited eye diseases, this paper provides a guide to the appropriate software required for identification of candidate genes through to the detection and analysis of mutations.
Lichanska
Agnieszka M
AM
Department of Ophthalmology, Queens University Belfast, Institute of Clinical Science, UK. A.Lichanska@qub.ac.uk
Simpson
David A C
DA
D002874:Chromosome Mapping; D003001:Cloning, Molecular; D019295:Computational Biology; D004252:DNA Mutational Analysis; D005128:Eye Diseases / Q000235:genetics*; D006801:Humans; D020407:Internet; D009154:Mutation