Susceptibility patterns of Gram-negative bacteria from a Polish intensive care unit, 1997-2000.
The susceptibility of Gram-negative bacterial strains (n=400) isolated from clinical specimens of children hospitalized in a Polish intensive care unit (ICU) between 1997 and 2000 was tested. Meropenem, imipenem and ciprofloxacin were most active (>90% susceptibility) against the tested isolates, with no observed reduction in activity over 4 years. Extended-spectrum beta-lactamases and AmpC beta-lactamase producers among Enterobacteriaceae isolates from this ICU continued to be a serious therapeutic problem, although the carbapenems were highly active against these resistance phenotypes. Resistance to aminoglycosides (gentamicin, tobramycin) and ceftazidime was a characteristic of >40% of tested isolates.
Patzer
Jan
J
Department of Clinical Microbiology, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-736, Warsaw, Poland. patzer@czd.waw.pl
Dzierzanowska
Danuta
D
Turner
Philip
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D003428:Cross Infection / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology; D015964:Gene Expression Regulation, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D015278:Intensive Care Units, Pediatric; D008826:Microbial Sensitivity Tests; D011044:Poland; D001618:beta-Lactamases / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases