Genome scans and microarrays: converging on genes for schizophrenia?
Systematic genome-wide scans to date have shown that genes of major effect are not common causes of schizophrenia, but independent linkage studies looking for schizophrenia susceptibility genes are converging on a number of key chromosomal locations. Microarray expression analysis may identify new candidate genes and pathways, and a number of intriguing preliminary findings have already been reported.
Williams
Nigel M
NM
Department of Psychological Medicine, Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Cardiff, CF14 4XN, UK. Williamsnm@cf.ac.uk
O'Donovan
Michael C
MC
Owen
Michael J
MJ
D002874:Chromosome Mapping; D020869:Gene Expression Profiling; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism