The case for more aggressive screening and treatment of mild thyroid failure.
"Subclinical" (mild) thyroid failure is not benign: it tends to progress to overt thyroid failure and it has adverse clinical effects. We believe it should be screened for more aggressively in the general population, and treated with levothyroxine.
Ayala
Alejandro R
AR
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Wartofsky
Leonard
L
D000368:Aged; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000517:prevention & control*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D012307:Risk Factors; D013959:Thyroid Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000627:therapeutic use*
D013974:Thyroxine