Impaired glucose tolerance as a determinant of early deterioration of left ventricular diastolic function in middle-aged healthy subjects.
To clarify the determinants of an abnormal relaxation diastolic pattern assessed by Doppler echocardiography, 131 middle-aged healthy subjects were analyzed. By multivariate logistic regression analysis, fasting insulin levels (p = 0.0016) and peak glucose levels (p = 0.046) were independent predictors of an abnormal relaxation diastolic pattern 2 hours after 75 g OGTT.
Okura
H
H
Department of Internal Medicine, Kobe Rehabilitation Hospital, Kobe, Japan.
Inoue
H
H
Tomon
M
M
Nishiyama
S
S
Yoshikawa
T
T
Yoshida
K
K
Yoshikawa
J
J
D003971:Diastole / Q000502:physiology; D005260:Female; D018149:Glucose Intolerance; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000503:physiopathology*