title: Solid-phase synthesis of 3-alkylamino-1,2,4-triazoles.
abstract: [reaction: see text] A solid-phase synthesis of trisubstituted 3-alkylamino-1,2,4-triazoles has been developed. The synthesis utilizes immobilized N-acyl-1H-benzotriazole-1-carboximidamides as key intermediates. Cyclization with hydrazines under mild conditions furnishes the title compounds with regioselectivity and high purity.
authors: NeoGenesis Pharmaceuticals, 840 Memorial Drive, Cambridge, Massachusetts 02139, USA. gregm@neogenesis.com
authors: Gergely M
authors: GM
authors: Makara
authors: Yao
authors: Y
authors: Ma
authors: Laura
authors: L
authors: Margarida
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D006834:Hydrazines / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D014230:Triazoles / Q000737:chemistry*
chemical_list: D006834:Hydrazines; D007202:Indicators and Reagents; D014230:Triazoles