CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis.
OBJECTIVE
Recent studies have shown that CD10 is a useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. The aim of this study was to investigate whether CD10 immunoreactivity is present in ectopic endometrial stroma and whether staining is of value in confirming a diagnosis of endometriosis.


RESULTS
Twenty five cases of endometriosis were stained with a commercially available antibody against CD10. Endometrial stromal cells were positive in 22 of 25 cases. There was little or no staining of other tissues.


CONCLUSIONS
CD10 immunoreactivity is largely maintained in endometrial stromal cells located outside the uterus. Immunohistochemical staining with CD10 may be of value in confirming a diagnosis of endometriosis when there is morphological doubt.
Sumathi
V P
VP
Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland.
McCluggage
W G
WG
D015415:Biomarkers / Q000032:analysis; D002921:Cicatrix / Q000378:metabolism; D004715:Endometriosis / Q000175:diagnosis*; D005260:Female; D052776:Female Urogenital Diseases / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007410:Intestinal Diseases / Q000175:diagnosis*; D015260:Neprilysin / Q000032:analysis*; D010532:Peritoneal Diseases / Q000175:diagnosis*; D017154:Stromal Cells / Q000378:metabolism
D015415:Biomarkers; D015260:Neprilysin