Isopestacin, an isobenzofuranone from Pestalotiopsis microspora, possessing antifungal and antioxidant activities.
Isopestacin is an isobenzofuranone obtained from the endophytic fungus Pestalotiopsis microspora. While a few other isobenzofuranones are known from natural sources, isopestacin is the only one having a substituted benzene ring attached at the C-3 position of the furanone ring. The compound was isolated from culture broths of the fungus and crystallized and its structure was determined by X-ray crystallography. Both proton and carbon NMR spectral assignments are also reported for isopestacin. This compound possesses antifungal activity and, as measured by electron spin resonance specroscopy, it also behaves as an antioxidant scavenging both superoxide and hydroxy free radicals.
Strobel
Gary
G
Department of Plant Sciences, Montana State University, Bozeman, MT 59717, USA. uplgs@montana.edu
Ford
Eugene
E
Worapong
Jeerepun
J
Harper
James K
JK
Arif
Atta M
AM
Grant
David M
DM
Fung
Peter C W
PC
Ming Wah Chau
Raymond
R
D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D018360:Crystallography, X-Ray; D004578:Electron Spin Resonance Spectroscopy; D005285:Fermentation; D005658:Fungi / Q000737:chemistry* / Q000187:drug effects* / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D015394:Molecular Structure
D000935:Antifungal Agents; D000975:Antioxidants; D001572:Benzofurans; C465645:isopestacin