title: A comparison of the anticarcinogenic properties of four red wine polyphenols.
abstract: BACKGROUND
  There has been growing interest in the analysis of certain polyphenols in wine, especially flavonoids, trihydroxystilbenes and phenolic acids, stimulated by intense research into their potential benefits to human health. One of their main properties in this regard is their antioxidant activity, which enables them to attenuate the development of atherosclerosis, inflammatory diseases, and cancer.
  
  
  METHODS
  A two stage CD-1 mouse skin cancer model using 9,10-dimethyl-1,2-benzanthracene (DMBA) as initiator and phorbol 12-myristate 13-acetate (TPA) as promoter was employed to compare the antitumorigenic activities of one polyphenol from each of four different classes: flavanols [(+)-catechin], stilbenes (trans-resveratrol), flavonols (quercetin) and hydroxybenzoic acids (gallic acid). Animals were treated with specific polyphenols at doses ranging from 0 to 25 micromoles (dissolved in 200 microL acetone), twice a week for eighteen weeks. The solution was applied topically to the shaved dorsal region of each animal. The relative potencies of the polyphenols were compared by evaluating the percentage inhibition of tumor formation in individual mice and the number of mice developing one or more tumors with the different dose schedules.
  
  
  RESULTS
  Probit analysis revealed that quercetin was the most (ED(50)<1 micromole) and gallic acid the least effective (ED(50) 5-10 micromoles). (+)-Catechin and trans-resveratrol were intermediate, with ED(50) values of 5 and 6 micromoles, respectively.
  
  
  CONCLUSIONS
  We have shown recently that trans-resveratrol is absorbed much more efficiently than (+)-catechin and quercetin in humans after oral consumption. Taking this and the relative concentrations in red wine into account, together with the present results, we conclude that trans-resveratrol may be the most effective anticancer polyphenol present in red wine as consumed po by healthy human subjects.
authors: Quality Assurance Department, Liquor Control Board of Ontario, 55 Lakeshore Blvd. E., Toronto, Ontario M5E 1A4, Canada.
authors: George J
authors: GJ
authors: Soleas
authors: Linda
authors: L
authors: Grass
authors: P David
authors: PD
authors: Josephy
authors: David M
authors: DM
authors: Goldberg
authors: Eleftherios P
authors: EP
authors: Diamandis
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D005419:Flavonoids; D005707:Gallic Acid / Q000494:pharmacology*; D051379:Mice; D010636:Phenols / Q000494:pharmacology; D011108:Polymers / Q000494:pharmacology; D011794:Quercetin / Q000494:pharmacology*; D000077185:Resveratrol; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D013267:Stilbenes / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity; D014920:Wine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D013267:Stilbenes; D015127:9,10-Dimethyl-1,2-benzanthracene; D005707:Gallic Acid; D002392:Catechin; D011794:Quercetin; D013755:Tetradecanoylphorbol Acetate; D000077185:Resveratrol