Screening the fruitfly immune system.
The anti-microbial defense system of Drosophila shows functional similarities with the vertebrate innate immune system. Two recent gene-expression profiling studies of fruitflies challenged with infectious agents have identified key molecular players in the fruitfly's response to bacterial and fungal infection, as well as a large number of immune-regulated genes with unknown immunological function.
Dionne
Marc S
MS
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5124, USA. dschneider@stanford.edu
Schneider
David S
DS
D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D020869:Gene Expression Profiling; D017344:Genes, Insect; D020411:Oligonucleotide Array Sequence Analysis