[Dependence of microwave effect on the secondary structure of DNA on molecular weight of polynucleotide].
The effect of ultralow power pulse-modulated electromagnetic radiation (average power density 60 microW/cm2, carrying frequency 1.05; 2.12; or 2.39 GHz; modulating pulses with frequency 4 Hz) on the secondary structure of DNA was investigated. It was established that the exposure of beta-alanine and formaldehyde containing aqueous DNA solution to electromagnetic radiation had activated the process of DNA despiralization under the action of beta-alanine--formaldehyde reaction product. The effect of electromagnetic radiation on the secondary structure of DNA can be removed by lowering of molecular weight of DNA to 0.46 x 10(6) (at carrying frequency 1.05 GHz), or to 0.25 x 10(3) (at carrying frequency 2.39 GHz).
Semin
Iu A
IuA
Medical Radiological Research Centre, Russian Academy of Medical Science, Obninsk, 249036 Russia.
Shvartsburg
L K
LK
Zhavoronkov
L P
LP
D000818:Animals; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D004574:Electromagnetic Fields; D005557:Formaldehyde; D051379:Mice; D008872:Microwaves; D008962:Models, Theoretical; D008970:Molecular Weight; D011829:Radiation Dosage; D013950:Thymus Gland / Q000378:metabolism; D013997:Time Factors; D015091:beta-Alanine
D015091:beta-Alanine; D005557:Formaldehyde; D004247:DNA