Disparate outcomes in patients with colorectal cancer: effect of race on long-term survival.
BACKGROUND
Increasing evidence suggests significant disparity in colorectal cancer outcomes between black and white patients. Contributing factors may include advanced tumor stage at diagnosis, differences in treatment, more aggressive tumor biology, access to care, and patient comorbidity.


OBJECTIVE
Disparities in colorectal cancer outcomes exist despite similar objective measures of treatment.


METHODS
Ten-year retrospective review of all patients with colorectal cancer using tumor registries at a city hospital (n = 83) and a university medical center (n = 585) in the same city. We assessed stage at diagnosis; curative surgical resection; use of adjuvant treatment; overall, disease-free, and stage-specific survival; and socioeconomic status. Patients with nonwhite, nonblack ethnicity (4% overall) were excluded. Differences in stage and treatments were compared using the chi(2) test, and median survival rates were compared using log-rank tests.


RESULTS
Significantly more black patients were treated at the city hospital (53.0%) vs the university medical center (10.6%) (P<.001). No differences were identified in stage distribution or treatments received between hospitals or between black and white patients. Significantly worse survival was noted among patients treated at the city hospital (2.1 vs 5.3 years; P<.001) and among black patients treated at both institutions (city hospital: 1.4 vs 2.1 years, and university hospital: 3.2 vs 5.7 years; P<.001 for both). Disease-free survival rates showed similar significant reductions for black patients at both institutions. There was no association between survival and socioeconomic status at either institution.


CONCLUSIONS
The marked reductions in overall and disease-free survival for black patients with colorectal cancer do not seem to be related to variation in treatment but may be due to biologic factors or non-cancer-related health conditions.
Wudel
L James
LJ
Division of Hepatobiliary and Liver Transplant Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Chapman
William C
WC
Shyr
Yu
Y
Davidson
Mark
M
Jeyakumar
Anita
A
Rogers
Selwyn O
SO
Allos
Tara
T
Stain
Steven C
SC
D001741:Black or African American; D000368:Aged; D044383:Black People; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000208:ethnology* / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D012042:Registries / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012959:Socioeconomic Factors; D016019:Survival Analysis; D015996:Survival Rate; D014481:United States; D044465:White People