title: Enhanced expression of neuronal nitric oxide synthase and phospholipase C-gamma1 in regenerating murine neuronal cells by pulsed electromagnetic field.
abstract: Pulsed electromagnetic field (PEMF) has been shown to improve the rate of peripheral nerve regeneration. In the present study we investigated the expression of neuronal nitric oxide synthase (nNOS) and phospholipase C-gamma1 (PLC-gamma1) in regenerating rat laryngeal nerves during the exposure to PEMF after surgical transection and reanastomosis. Axons were found to regenerate into the distal stump nearly twice faster in PEMF-exposed animals than in the control. Consistently, motor function was better recovered in PEMF-treated rats. The expression of nNOS and PLC-gamma1 was highly enhanced in the regenerated nerves.
authors: Department of Pathology, Ulsan University College of Medicine, Korea.
authors: Sung Sook
authors: SS
authors: Kim
authors: Hye Jung
authors: HJ
authors: Shin
authors: Dae Woon
authors: DW
authors: Eom
authors: Joo Ryung
authors: JR
authors: Huh
authors: Yeongju
authors: Y
authors: Woo
authors: Hyokyung
authors: H
authors: Kim
authors: Sung Ho
authors: SH
authors: Ryu
authors: Pann Gill
authors: PG
authors: Suh
authors: Moon Jung
authors: MJ
authors: Kim
authors: Jee Yun
authors: JY
authors: Kim
authors: Tae Wan
authors: TW
authors: Koo
authors: Yoon Hee
authors: YH
authors: Cho
authors: Sung Min
authors: SM
authors: Chung
mesh_terms: D000818:Animals; D004574:Electromagnetic Fields; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D009416:Nerve Regeneration / Q000502:physiology / Q000528:radiation effects; D009474:Neurons / Q000502:physiology* / Q000528:radiation effects; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D052248:Nitric Oxide Synthase Type I; D051966:Phospholipase C gamma; D051381:Rats; D017207:Rats, Sprague-Dawley; D012009:Recurrent Laryngeal Nerve / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects* / Q000601:surgery; D010738:Type C Phospholipases / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496322:Nos1 protein, rat; D010738:Type C Phospholipases; D051966:Phospholipase C gamma