Experimental mandibular regeneration by distraction osteogenesis with submerged devices: preliminary results of a canine model.
The authors describe a new technique for reconstruction of mandibular body defects. The feasibility of distraction osteogenesis with submerged (internal) devices for reconstruction of segmental mandibular defects is investigated in an experiment with five adult dogs. A segmental mandibulectomy was performed on the horizontal ramus. The bony defect was regenerated using distraction osteogenesis (bone transport) at a rate of 1 mm daily. The animals were killed after the consolidation period. Complete bone regeneration of the surgically created gap was successful in three of five dogs. Two animals failed to create new bone. In these two cases, the screws did not offer proper stability to the bony fragments, and this caused a lack of ossification. This experimental study demonstrates the possibility to use internal distraction devices to reconstruct segmental mandibular defects in a canine model. Internal devices show enormous advantages in comparison with the external ones. This method with no donor-site morbidity may become a very useful option in human mandibular reconstruction.
Rubio-Bueno
Pilar
P
Department of Oral and Maxillofacial Surgery, Hospital Universitario de la Princesa, Diego de León 62, 28006-Madrid, Spain. piluca10@jazzfree.com
Sanromán
Fidel
F
García
Paloma
P
Sánchez
Mercedes
M
Llorens
Pilar
P
Nieto
Santiago
S
Adrados
Magdalena
M
Sastre
Jesús
J
de Artiñano
Fernando Ortiz
FO
Amde
Samuel
S
Naval
Luis
L
Díaz-González
Francisco J
FJ
D000818:Animals; D001861:Bone Regeneration; D004285:Dogs; D016268:Internal Fixators; D008334:Mandible / Q000601:surgery*; D023421:Models, Animal; D019857:Osteogenesis, Distraction / Q000295:instrumentation*