Incorrect biochemistry complicates prostate cancer management.
A man with a prostate specific antigen (PSA) of 6.1 ng/mL, a clinical stage T2b prostate nodule and biopsies that showed Gleason sum 6 adenocarcinoma of the prostate underwent a radical prostatectomy. The final pathology showed organ-confined disease. His postoperative PSA remained elevated at 4.0 ng/mL. The PSA was repeated several times and was in the same range. It was re-evaluated at another lab facility and was unmeasurable (<0.02 ng/mL). He has an antibody that cross-reacts with an assay reagent causing this false reading. The most likely antibody is one against mouse immunoglobulin G (IgG).
McAuley
Iain
I
Department of Urology, Capital Health Region, Royal Jubilee Hospital, Victoria, BC, Canada.
Steinhoff
Gary
G
McNeely
Michael
M
Blood
Paul
P
D000230:Adenocarcinoma / Q000097:blood* / Q000601:surgery; D005189:False Positive Reactions; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000175:diagnosis; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000601:surgery
D015483:HIV Antibodies; D017430:Prostate-Specific Antigen