title: Parvovirus B19 nonstructural (NS1) protein as a transactivator of interleukin-6 synthesis: common pathway in inflammatory sequelae of human parvovirus infections?
abstract: This review focuses on the role that human parvovirus B19 nonstructural (NS1) protein as a transactivator of the proinflammatory cytokine, interleukin-6 (IL-6), might play in triggering the multiparametric inflammatory outcomes of B19 infection. Parvovirus B19 is a ubiquitous virus, and it is often expressed during conditions of immunodepression including that induced by long-term chemotherapy, viral infection (HIV, HTLV-1), or genetic immunodeficiency disorders. Through NS1 expression, B19 may contribute to the immune dysregulation associated with these disorders, or serve as a cofactor in enhancing retroviral replication. Hence, NS1 transactivation of proinflammatory cytokine promoters such as IL-6 may be pivotal in triggering the various inflammatory and autoimmune disorders that have been linked to parvovirus B19 infections.
authors: Department of Pathology, University of British Columbia, Vancouver, Canada. lmitchel@hadassah.org.il
authors: Leslie Ann
authors: LA
authors: Mitchell
mesh_terms: D001168:Arthritis / Q000276:immunology / Q000503:physiopathology; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology*; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000235:genetics; D010322:Parvoviridae Infections / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D016732:Parvovirus B19, Human / Q000276:immunology / Q000502:physiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D015533:Transcriptional Activation; D017361:Viral Nonstructural Proteins / Q000276:immunology / Q000378:metabolism*
chemical_list: D015850:Interleukin-6; C106202:NS1 protein, parvovirus; D017361:Viral Nonstructural Proteins