Comparative investigations of hydroxyamine carane derivative and its R,S-diastereoisomers with strong local anesthetic activity.
Our previously conducted pharmacological screening led as to the discovery of the strong local anesthetic activity of the compound designated as KP-23. Earlier crystallographic studies revealed that the compound KP-23 crystallized in diastereoisomeric form in lowest symmetry. The aim of these comparative investigations was to evaluate anesthetic activity of KP-23 and its R,S-diastereoisomers, which were synthesized at the Institute of Organic Chemistry, Biochemistry and Biotechnology, Wroclaw University of Technology.
Librowski
T
T
Department of Pharmacodynamics, Medical College, Jagiellonian University, Kraków, Poland. mflibrow@kinga.cyf-kr.edu.pl
Czarnecki
R
R
Lochyński
S
S
Frackowiak
B
B
Pasenkiewicz-Gierula
M
M
Grochowski
J
J
Serda
P
P
D000779:Anesthetics, Local / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000081008:Bicyclic Monoterpenes; D003514:Cyclohexylamines / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism
D000779:Anesthetics, Local; D000081008:Bicyclic Monoterpenes; D003514:Cyclohexylamines; C079300:4-(2-hydroxy-3-(N-isopropylamino)propoxyimino)carane