A novel water-soluble Hantzsch 1,4-dihydropyridine compound that functions in biological processes through NADH regeneration.
A novel Hantzsch 1,4-dihydropyridine derivative could function in an organic solvent-free solution, and thus it could function in biological systems. These functions can be accomplished through regeneration of the reduced form of nicotinamine adenine dinucleotide (NADH), an essential compound for living organisms. The results obtained here demonstrate the usefulness of a water-soluble Hantzsch 1,4-dihydropyridine derivative and its wide applicability as a chemical energy source, which drives various biological processes efficiently.
Sambongi
Yoshihiro
Y
Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan. ueda@sanken.osaka-u.ac.jp
Nitta
Hajime
H
Ichihashi
Kayoko
K
Futai
Masamitsu
M
Ueda
Ikuo
I
D002625:Chemistry, Organic / Q000379:methods; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D004926:Escherichia coli / Q000378:metabolism; D008566:Membranes / Q000187:drug effects; D015394:Molecular Structure; D009243:NAD / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
C466879:2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester; D004095:Dihydropyridines; D009243:NAD; C038806:1,4-dihydropyridine