[Hypotensive effect of long-acting garlic tablets allicor (a double-blind placebo-controlled trial)].
OBJECTIVE
To evaluate a hypotensive action of long-acting garlic powder tablets allicor in patients with mild or moderate hypertension and to compare allicor effects with those of foreign analog--kwai garlic tablets.


METHODS
A double-blind, randomized and placebo-controlled study enrolled 85 patients with mild or moderate hypertension. The patients were divided into 4 groups: group 1 received allicor in a dose 600 mg/day, group 2--2400 mg/day, group 3--kwai in a dose 900 mg/day, group 4--placebo.


RESULTS
Allicor produced reaction in both systolic and diastolic pressure. An increase of allicor daily dose to 2400 mg does not provide an additional hypotensive effect. Kwai results in only systolic but not diastolic arterial pressure lowering.


CONCLUSIONS
Allicor is more effective than kwai in reduction of diastolic blood pressure. It can be recommended as a hypotensive treatment in mild and moderate arterial hypertension.
Andrianova
I V
IV
Fomchenkov
I V
IV
Orekhov
A N
AN
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005737:Garlic; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010919:Placebos; D028321:Plant Preparations / Q000627:therapeutic use*; D013607:Tablets
D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; D010919:Placebos; D028321:Plant Preparations; D013607:Tablets