Effects of zopiclone on blood glucose level, serum lipid concentration and clot lysis time in normoglycemic and normolipidemic rats.
In normoglycemic and normolipidemic rats the i.p. injection of zopiclone induced an acceleration of fibrinolysis in a dose-dependent bell shaped manner and various changes of the blood glucose level. Total lipids, total cholesterol and triglyceride serum levels remained unaffected by doses of 1.25, 2.5 and 15.0 mg/kg, with the exception of the medium dose (5.0 mg/kg) and the next dose (10.0 mg/kg) which lowered them very significantly.
Horák
J
J
Department of Pharmacology, Faculty of Medicine and Pharmacy, University of Oradea, Cluj Napoca, Romania.
Cuparencu
B
B
Horák
A
A
D000818:Animals; D053961:Azabicyclo Compounds; D001786:Blood Glucose / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D011345:Fenofibrate / Q000494:pharmacology; D005342:Fibrinolysis / Q000187:drug effects*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008055:Lipids / Q000097:blood*; D008297:Male; D009994:Osmolar Concentration; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013997:Time Factors
D053961:Azabicyclo Compounds; D001786:Blood Glucose; D006993:Hypnotics and Sedatives; D000960:Hypolipidemic Agents; D008055:Lipids; D010879:Piperazines; C515050:zopiclone; D011345:Fenofibrate