Cortical dysplasia localized by [11C]methionine positron emission tomography: case report.
Numerous functional neuroimaging techniques have progressively been added to the presurgical evaluation of refractory partial epilepsies. These investigations can help confirm the origin of seizure onset previously suggested by MR imaging and electro-clinical data, provide independent prognostic information, and provide critical diagnostic value when MR imaging results are strictly normal or show multifocal abnormalities. Of the various functional neuroimaging modalities, [11C]methionine positron emission tomography for methionine uptake into seizure foci is still in the preliminary stages of investigation. A single case of medically intractable epilepsy with focal cortical dysplasia documented by [11C]methionine positron emission tomography and possible hypotheses to explain the methionine uptake into the seizure focus are described below.
Madakasira
Padma Vasantha
PV
Wallace Kettering Neuroscience Institute, Kettering Medical Center, Kettering, OH 45429, USA.
Simkins
Robert
R
Narayanan
Tanjore
T
Dunigan
Kelly
K
Poelstra
Raymond J
RJ
Mantil
Joseph
J
D000328:Adult; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000000981:diagnostic imaging* / Q000473:pathology; D004828:Epilepsies, Partial / Q000209:etiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008715:Methionine; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D008715:Methionine