A potent polymer/pyridoxamine enzyme mimic.
An enzyme mimic consisting of pyridoxamines covalently linked to polyethyleneimine carrying long-chain alkyl groups converts pyruvic acid to dl-alanine with as much as an 8000-fold acceleration relative to the reaction with simple pyridoxamine at the same pyridoxamine concentration. The acceleration by polymer is a strong function of the length of the alkyl chains that are appended. The polymer furnishes acid and base groups to catalyze the proton transfers that are involved in transamination.
Liu
Lei
L
Department of Chemistry, Columbia University, New York, New York 10027, USA.
Breslow
Ronald
R
D007700:Kinetics; D018716:Molecular Mimicry; D011094:Polyethyleneimine / Q000737:chemistry* / Q000378:metabolism; D011733:Pyridoxamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship; D000637:Transaminases / Q000737:chemistry* / Q000378:metabolism
D011733:Pyridoxamine; D011094:Polyethyleneimine; D000637:Transaminases