NF-kappaB in cancer: from innocent bystander to major culprit.
Nuclear factor of kappaB (NF-kappaB) is a sequence-specific transcription factor that is known to be involved in the inflammatory and innate immune responses. Although the importance of NF-KB in immunity is undisputed, recent evidence indicates that NF-kappaB and the signalling pathways that are involved in its activation are also important for tumour development. NF-kappaB should therefore receive as much attention from cancer researchers as it has already from immunologists.
Karin
Michael
M
Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla 92093, USA. karinoffice@ucsd.edu
Cao
Yixue
Y
Greten
Florian R
FR
Li
Zhi-Wei
ZW
D000818:Animals; D006801:Humans; D008206:Lymphatic Diseases / Q000378:metabolism; D008954:Models, Biological; D016328:NF-kappa B / Q000096:biosynthesis*; D009369:Neoplasms / Q000378:metabolism*; D015398:Signal Transduction
D016328:NF-kappa B