In vitro susceptibility of vancomycin-resistant enterococci (VRE) to fosfomycin.
We evaluated the in vitro activity of fosfomycin against 75 clinical isolates of vancomycin-resistant enterococci (VRE). Using the NCCLS breakpoint for susceptibility of urinary tract isolates to fosfomycin (MIC > or = 256), 51 out of 52 Enterococcus faecium and all Enterococcus faecalis isolates tested were susceptible or intermediate to fosfomycin.
Perri
Mary Beth
MB
Department of Medicine, Section of Infectious Diseases, William Beaumont Hospital, Royal Oak, MI, USA.
Hershberger
Ellie
E
Ionescu
Mihaela
M
Lauter
Carl
C
Zervos
Marcus J
MJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000302:isolation & purification; D016984:Enterococcus faecium / Q000187:drug effects* / Q000302:isolation & purification; D005578:Fosfomycin / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D005578:Fosfomycin