Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2/PRA.
Subcutaneous vaccination with recombinant antigen 2/PRA (rAg2/PRA) protected BALB/c mice against intranasal infection with Coccidioides immitis. Subcutaneously vaccinated C57BL/6 mice and intranasally vaccinated BALB/c mice were protected against larger numbers of infecting spores. Weight loss correlated with lethality, but histologic appearance did not. These studies support rAg2/PRA vaccination to prevent coccidioidomycosis.
Shubitz
Lisa
L
Valley Fever Center for Excellence, Medicine and Subspecialties Program, Research Program, Southern Arizona Veterans Affairs Health Care System, Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona 85723, USA.
Peng
Tao
T
Perrill
Robert
R
Simons
Julie
J
Orsborn
Kris
K
Galgiani
John N
JN
D000281:Administration, Intranasal; D000818:Animals; D000946:Antigens, Fungal / Q000008:administration & dosage / Q000276:immunology*; D003045:Coccidioides / Q000276:immunology; D003047:Coccidioidomycosis / Q000401:mortality / Q000517:prevention & control*; D004195:Disease Models, Animal; D005260:Female; D005656:Fungal Proteins; D005657:Fungal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006023:Glycoproteins / Q000008:administration & dosage / Q000276:immunology*; D007279:Injections, Subcutaneous; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000382:microbiology / Q000473:pathology; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology*; D015431:Weight Loss
D000946:Antigens, Fungal; D005656:Fungal Proteins; D005657:Fungal Vaccines; D006023:Glycoproteins; D014614:Vaccines, Synthetic; C102758:antigen 2, Coccidioides