title: Analysis of formulation and food effect on the absorption of metoclopramide.
abstract: OBJECTIVE
  Assessment of the relative and absolute bioavailability of immediate release and sustained release formulations of metoclopramide. Assessment of the effect of a high-fat meal on the pharmacokinetics of sustained release metoclopramide.
  
  
  METHODS
  In a balanced 4-way crossover study in 16 healthy male volunteers, a sustained release (SR) formulation of metoclopramide was compared with a solution for injection (A) and an immediate release tablet (B). The SR formulation was administered after a fasting period (C) as well as after a high-fat meal (D). A single dose of 30 mg metoclopramide was investigated in each treatment. Metoclopramide concentrations were determined by HPLC.
  
  
  RESULTS
  The absolute bioavailability of the sustained release formulation (fasting state) was 58% and thus about 17% lower than the bioavailability of the immediate release formulation. Comparing the treatments C (sustained release, fasting state) and D (sustained release, high-fat meal) no significant influence of food on the absorption of sustained release metoclopramide could be detected.
authors: Medical Affairs Arthritis/MDI, Pharmacia GmbH, Erlangen, Germany. hartmut.vergin@pharmacia.com
authors: H
authors: H
authors: Vergin
authors: U
authors: U
authors: Fisch
authors: G
authors: G
authors: Mahr
authors: B
authors: B
authors: Winterhalter
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D003692:Delayed-Action Preparations; D004041:Dietary Fats; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004435:Eating; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D003692:Delayed-Action Preparations; D004041:Dietary Fats; D018492:Dopamine Antagonists; D008787:Metoclopramide