Correspondence re: Raida, M. et al., prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls.
Innocenti
Federico
F
Ratain
Mark J
MJ
D017398:Alternative Splicing / Q000235:genetics; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D003967:Diarrhea / Q000139:chemically induced / Q000473:pathology; D042943:Dihydrouracil Dehydrogenase (NADP); D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics; D007970:Leukopenia / Q000139:chemically induced / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics; D010088:Oxidoreductases / Q000235:genetics*; D017354:Point Mutation; D012720:Severity of Illness Index; D013280:Stomatitis / Q000139:chemically induced / Q000473:pathology; D013921:Thrombocytopenia / Q000139:chemically induced / Q000473:pathology
D000964:Antimetabolites, Antineoplastic; D010088:Oxidoreductases; D042943:Dihydrouracil Dehydrogenase (NADP); D005472:Fluorouracil