Monofocal motor neuropathy: Improvement with intravenous immunoglobulin.
Multifocal motor neuropathy (MMN) is a chronic, immune-mediate, peripheral myelinopathy. Inherent in its name, MMN implies involvement of two or more motor nerves. We report three patients with weakness and partial motor conduction block restricted to a single nerve and localized to sites that are not at risk for entrapment or compression injury. None of the patients had sensory involvement and all showed a favorable response to intravenous immunoglobulin therapy. Based on these observations and reports of three additional patients, we believe that monofocal motor neuropathy is a partial form of MMN and should be treated as such.
Felice
Kevin J
KJ
Department of Neurology, MC1840, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, Connecticut 06030-1840, USA.
Goldstein
Jonathan M
JM
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
D000200:Action Potentials; D000328:Adult; D004594:Electrophysiology; D005260:Female; D005528:Foot; D006225:Hand; D006801:Humans; D016756:Immunoglobulins, Intravenous; D008297:Male; D016472:Motor Neuron Disease / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D009046:Motor Neurons / Q000502:physiology; D018908:Muscle Weakness / Q000209:etiology; D018482:Muscle, Skeletal / Q000503:physiopathology; D009431:Neural Conduction; D011930:Reaction Time; D016896:Treatment Outcome
D016756:Immunoglobulins, Intravenous