title: Epidemiological survey on the relationship between different iodine intakes and the prevalence of hyperthyroidism.
abstract: OBJECTIVE
  To investigate the effect of different levels of iodine intake on the prevalence of hyperthyroidism and the impact of universal salt iodization on the incidence of hyperthyroidism.
  
  
  METHODS
  A comparative cross-sectional and longitudinal survey was conducted in three areas with borderline iodine deficiency, mild iodine excess (previously mild iodine deficiency) and severe iodine excess. Universal salt iodization had been introduced 3 years previously except in the area with borderline iodine deficiency.
  
  
  METHODS
  In total 16 287 inhabitants from three areas answered a questionnaire concerning the history of thyroid disease. Among them 3761 unselected subjects received further investigations including thyroid function, thyroid autoantibodies, thyroid ultrasonography and urinary iodine excretion.
  
  
  RESULTS
  Among areas with median urinary iodine excretion of 103 microg/l, 375 microg/l and 615 microg/l (P<0.05), the prevalence of hyperthyroidism did not differ significantly (1.6%, 2% and 1.2%). The prevalence of subclinical hyperthyroidism was higher in areas with borderline iodine deficiency and mild iodine excess than in the area with severe excess iodine intake (3.7%, 3.9% and 1.1%, P<0.001). The prevalence of Graves' disease and its proportion in hyperthyroidism did not differ among areas. The incidence of hyperthyroidism did not significantly increase after the introduction of universal salt iodization.
  
  
  CONCLUSIONS
  Different iodine intakes under a certain range do not affect the prevalence and type of hyperthyroidism. Subclinical hyperthyroidism is more prevalent in the iodine deficient area than in the severe iodine excessive area. In the area with mild iodine deficiency, the introduction of universal salt iodization may not be accompanied by an increased incidence of hyperthyroidism.
authors: Department of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China.
authors: Fan
authors: F
authors: Yang
authors: Weiping
authors: W
authors: Teng
authors: Zhongyan
authors: Z
authors: Shan
authors: Haixia
authors: H
authors: Guan
authors: Yushu
authors: Y
authors: Li
authors: Ying
authors: Y
authors: Jin
authors: Fengnan
authors: F
authors: Hu
authors: Xiaoguang
authors: X
authors: Shi
authors: Yajie
authors: Y
authors: Tong
authors: Wei
authors: W
authors: Chen
authors: Bai
authors: B
authors: Yuan
authors: Zhanyi
authors: Z
authors: Wang
authors: Bingyuan
authors: B
authors: Cui
authors: Shiming
authors: S
authors: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D004034:Diet Surveys; D005260:Female; D006042:Goiter / Q000453:epidemiology; D006801:Humans; D006980:Hyperthyroidism / Q000145:classification / Q000453:epidemiology* / Q000503:physiopathology; D015994:Incidence; D007455:Iodine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D015995:Prevalence; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage
chemical_list: D017673:Sodium Chloride, Dietary; C034024:iodized salt; D007455:Iodine