Phototransduction for human melatonin suppression.
Human adult males were exposed to combinations of two illuminances and two broadband spectral power distributions over the course of four night-time sessions. Results showed that melatonin suppression is dominated by short visible wavelengths (420-520 nm), consistent with recently published studies. Although the authors of these recent studies suggest that a novel opsin underlies melatonin suppression, the present paper offers a more conservative interpretation of the data based on what is known about existing photoreceptors and associated neuroanatomy and neurophysiology.
Rea
Mark S
MS
Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY, USA. ream@rpi.edu
Bullough
John D
JD
Figueiro
Mariana G
MG
D000328:Adult; D006801:Humans; D008027:Light; D008297:Male; D008550:Melatonin / Q000037:antagonists & inhibitors* / Q000097:blood; D011863:Radioimmunoassay
D008550:Melatonin