title: Shikonin derivatives: synthesis and inhibition of human telomerase.
abstract: We synthesized DL-shikonin, shikonin, alkanin, and their cyclo-derivatives and acyl-derivatives. These compounds have low cytotoxicity, as well as inhibitory activity against the telomerase enzyme, except cyclo-derivatives.
authors: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Science, 200031, Shanghai, PR China.
authors: Qun
authors: Q
authors: Lu
authors: Weijun
authors: W
authors: Liu
authors: Jian
authors: J
authors: Ding
authors: Junchao
authors: J
authors: Cai
authors: Wenhu
authors: W
authors: Duan
mesh_terms: D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D013053:Spectrophotometry; D013329:Structure-Activity Relationship; D019098:Telomerase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D009285:Naphthoquinones; C016101:shikonin; D019098:Telomerase