GABA(B) receptor agonist baclofen attenuates the development and expression of d-methamphetamine-induced place preference in rats.
The present study investigated the effect of systemic administration of the GABA(B) receptor agonist, baclofen, on the development and expression of d-methamphetamine (d-MA)-induced place preference in male Wistar rats. Using a biased and 8-day schedule of conditioning, it was found that administration of d-MA (0.5 mg/kg, i.p.) produced significant place preference. The administration of baclofen (2.5 and 5.0 mg/kg, i.p.) 30 min prior to the exposure to d-MA attenuated the development of d-MA-induced place preference (p<0.05). In addition, when it was acutely administered 30 min prior to the testing session of an already established d-MA place preference, baclofen (1.25-5.0 mg/kg, i.p.) attenuated the expression of this conditioned response in a dose-dependent manner. These results showed that baclofen suppressed the rewarding effect produced by d-MA and may be potentially effective in the treatment of methamphetamine dependence and craving.
Li
S M
SM
National Institute on Drug Dependence, Peking University, Beijing, PR China.
Yin
L L
LL
Ren
Y H
YH
Pan
L S
LS
Zheng
J W
JW
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D058786:GABA-B Receptor Agonists; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012054:Reinforcement, Psychology
D058786:GABA-B Receptor Agonists; D001418:Baclofen; D003913:Dextroamphetamine