title: Perioperative hemodynamic and geometric changes of the left ventricle during cardiomyoplasty in goats with dilated left ventricle.
abstract: OBJECTIVE
  Clinical data have suggested the occurrence of temporary short-term deterioration of the heart following cardiomyoplasty. The purpose of this study was to monitor the short-term hemodynamic effects of cardiomyoplasty in a goat model of a dilated left ventricle, using conductance catheters (ie, pressure-volume loops) and cardiac output measurements.
  
  
  METHODS
  Eight female goats underwent acute cardiomyoplasty 8 to 12 weeks after left ventricular (LV) dilatation was induced by a carotid jugular arteriovenous shunt. The cardiomyoplasty procedure was monitored using a Swan-Ganz catheter for cardiac output measurements and a 12-electrode (dual-field) conductance catheter to LV pressure-volume loops.
  
  
  RESULTS
  After wrapping the heart with the latissimus dorsi muscle, there was a significant reduction in both cardiac output and LV end-diastolic volume (LVEDV) at 10 min. Partial recovery was observed 45 min later.
  
  
  CONCLUSIONS
  A decrease in both cardiac output and LVEDV was observed following myocardial wrapping. This may explain some of the perioperative and postoperative morbidity and mortality observed following cardiomyoplasty.
authors: Department of Cardiothoracic Surgery, Tel Aviv Sourasky Medical Center, Division of Cardiac Surgery, Tel Aviv, Israel. bolotin@netvision.net.il
authors: Gil
authors: G
authors: Bolotin
authors: Roberto
authors: R
authors: Lorusso
authors: Jan J
authors: JJ
authors: Schreuder
authors: Nahum
authors: N
authors: Nesher
authors: Hans
authors: H
authors: Kaulbach
authors: Gideon
authors: G
authors: Uretzky
authors: Frederick
authors: F
authors: van der Veen
mesh_terms: D000818:Animals; D002302:Cardiac Output; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology* / Q000601:surgery; D018421:Cardiomyoplasty; D005260:Female; D006041:Goats; D006439:Hemodynamics; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology / Q000601:surgery; D013318:Stroke Volume; D016277:Ventricular Function, Left