title: Synthesis and in vitro cytotoxic and antiviral activities of 1-(2,5,6-trideoxy-6-halogenohept-5-enofuranurononitrile)thymine and derivatives.
abstract: All 1-(2,5,6-trideoxy-6-halogenohept-5-enofuranurononitrile)thymine and their 3'-O-TBDMS derivatives have been prepared and their configuration established. Some of these compounds are endowed with a cytotoxic or cytostatic activity in cell culture. The single most important factor affecting the cytotoxicity of these compounds is the presence on the molecule of a soft (electrofugal) halogen atom.
authors: Department of Organic Pharmaceutical Chemistry, University of Geneva, Sciences II, Switzerland.
authors: Jean M J
authors: JM
authors: Tronchet
authors: Frederic
authors: F
authors: Chalard
authors: Elisabeth
authors: E
authors: Rivara-Minten
authors: Michel
authors: M
authors: Seman
authors: Erik
authors: E
authors: De Clercq
authors: Jan
authors: J
authors: Balzarini
authors: Pierre
authors: P
authors: Dilda
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D017646:Organosilicon Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D013941:Thymine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000998:Antiviral Agents; D017646:Organosilicon Compounds; C009660:t-butyldimethylsilyl compounds; D013941:Thymine