The cellular basis of contraction in human detrusor smooth muscle from patients with stable and unstable bladders.
Studying the cellular physiology of human detrusor muscle obtained from patients with normally functioning bladders and comparing it with that of detrusor muscle from patients with unstable bladders may help identify potential targets for drug therapy in patients with abnormal bladder function. Considerable advances have been made in the understanding of the cellular processes that result in contraction and relaxation of detrusor smooth muscle, particularly in the role and modulation of calcium. Several changes in these cellular mechanisms that impair normal function have been observed in detrusor muscle from patients with unstable bladders. Whether these changes represent primary causes of bladder dysfunction or whether they are secondary to bladder dysfunction remains to be determined. Nevertheless, the identification of specific cellular lesions in bladder dysfunction presents a novel approach to identification of drug targets and potential treatment modalities.
Fry
Christopher H
CH
Institute of Urology & Nephrology, University College London, London, United Kingdom. c.fry@ucl.ac.uk
Skennerton
Deborah
D
Wood
Dan
D
Wu
Changhao
C
D000255:Adenosine Triphosphate / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D002468:Cell Physiological Phenomena; D006801:Humans; D009119:Muscle Contraction / Q000502:physiology*; D009126:Muscle Relaxation / Q000502:physiology; D009130:Muscle, Smooth / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology; D001743:Urinary Bladder / Q000166:cytology / Q000502:physiology*; D001745:Urinary Bladder Diseases / Q000473:pathology / Q000503:physiopathology*
D015220:Calcium Channels; D018377:Neurotransmitter Agents; D015222:Sodium Channels; D000255:Adenosine Triphosphate; D002118:Calcium