Diacylglycerol kinases: emerging downstream regulators in cell signaling systems.
Diacylglycerol kinase (DGK) regulates signal transduction by modulating the balance between the two signaling lipids, diacylglycerol and phosphatidic acid. DGK and its homologs occur in a wide range of multicellular organisms and the mammalian DGK is known to consist of nine members with a considerable incidence of alternative splicing. Recent work has established that DGK serves as a key attenuator of diacylglycerol of signaling functions and that the mammalian isozymes are equipped with molecular machineries which enable them to act in specific intracellular sites and/or in signaling protein complexes.
Kanoh
Hideo
H
Department of Biochemistry, School of Medicine, Sapporo Medical University, South-West-17, Sapporo 060-8556, Japan. kanoh@sapmed.ac.jp
Yamada
Keiko
K
Sakane
Fumio
F
D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D017124:Conserved Sequence; D019852:Diacylglycerol Kinase / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004075:Diglycerides / Q000378:metabolism; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D010712:Phosphatidic Acids / Q000378:metabolism; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism; D011955:Receptors, Drug / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014443:Tyrosine / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D004075:Diglycerides; D007527:Isoenzymes; D010712:Phosphatidic Acids; D011955:Receptors, Drug; C083141:phorbol ester binding protein; C027776:phorbol ester receptor; D014443:Tyrosine; D019852:Diacylglycerol Kinase; D011493:Protein Kinase C