Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger?
Nicotinic acid adenine dinucleotide phosphate (NAADP) is one of the most potent stimulators of intracellular Ca2+ release known to date. The role of the NAADP system in physiological processes is being extensively investigated at the present time. Exciting new discoveries in the last 5 years suggest that the NAADP-regulated system may have a significant role in intracellular Ca2+ signaling. The NAADP receptor and its associated Ca2+ pool have been hypothesized to be important in several physiological processes including fertilization, T cell activation, and pancreatic secretion. However, whether NAADP is a new second messenger or a tool for the discovery of a new Ca2+ channel is still an unanswered question.
Chini
Eduardo N
EN
Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. chini.eduardo@mayo.edu
De Toledo
Frederico G S
FG
D000818:Animals; D002118:Calcium / Q000378:metabolism; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism; D009249:NADP / Q000031:analogs & derivatives* / Q000502:physiology*; D010063:Ovum / Q000378:metabolism; D010944:Plants; D012617:Sea Urchins; D015290:Second Messenger Systems / Q000502:physiology*
D009249:NADP; C024376:NAADP; D002118:Calcium