Apolipoprotein E4 and tau allele frequencies among Choctaw Indians.
Apolipoprotein genotyping and tau haplotyping were carried out on a series of cases with dementia and controls from the Choctaw Nation of Oklahoma. Both the Apolipoprotein E4 allele frequency and the tau H2 haplotype frequency were low in the Choctaw compared with Caucasians and there was the possibility that the association between dementia and the E4 allele was weaker than in Caucasians.
Henderson
J Neil
JN
Department of Health Promotion Sciences, University of Oklahoma, Oklahoma City 73190, USA.
Crook
Richard
R
Crook
Julia
J
Hardy
John
J
Onstead
Luisa
L
Carson-Henderson
Linda
L
Mayer
Pat
P
Parker
Bea
B
Petersen
Ronald
R
Williams
Birdie
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000208:ethnology* / Q000235:genetics* / Q000378:metabolism; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009825:Oklahoma / Q000208:ethnology; D044465:White People / Q000235:genetics; D016875:tau Proteins / Q000235:genetics* / Q000378:metabolism
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D005819:Genetic Markers; D016875:tau Proteins