[Peculiarities of latex allergy and preventive measures in the pediatric age group].
Latex allergy can be considered a problem of public health in at-risk populations. Although the figures on prevalence vary, approximately 1 % of the general population is sensitized to latex. To date, two determining factors for latex sensitization have been identified: an atopic predisposition and the number of operations. Among atopic patients or those at-risk for allergy, the prevalence of latex sensitization is between 3 and 20 times higher than that among the general population. Nevertheless, the effect of this factor seems to be modulatory and the determining factor seems to be the number of operations that children have undergone; the critical number is 5-6 interventions, after which the probability of sensitization increases considerably.All children who have undergone multiple operations should be considered as being at-risk. Children with spina bifida are especially at-risk. The reasons for this are still a matter of debate: the disease itself has been postulated as a specific risk factor, although other, possible associated factors could be determinant in triggering latex sensitization (the presence of a ventricular-peritoneal shunt, age at which surgery was performed, type of operation, etc.). Children with spina bifida and latex allergy show considerable differences in type of allergic sensitization; these differences seem to result from the different route of sensitization and could explain the variations observed in the clinical manifestations between children and adults: children become sensitized mainly by direct contact between latex particles and blood vessels and open mucosae while in adults the process takes place transcutaneously or by inhalation of aerosol particles. Consequently, the most frequent manifestation in children is urticaria while contact dermatitis and respiratory symptoms predominate in adults. Studies performed with immunoblotting have confirmed that children have IgE that almost constantly recognize low molecular weight latex proteins (14, 15 and 27 Kd) while this finding is less frequent in adults.The preventive measures in the pediatric population focus on avoidance of latex, especially in hospitals. Today, latex is ubiquitous, making complete avoidance difficult. When necessary, and whenever a latex-free environment cannot be guaranteed, presurgical medication can be used, although its utility is debatable. Although further studies are required, specific immunotherapy is one therapeutic possibility that may in future be used in children with latex allergy.
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Unidad de Alergia Pediátrica. Hospital Infantil La Fe. Valencia. Spain.
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D002648:Child; D005260:Female; D006801:Humans; D020315:Latex Hypersensitivity / Q000276:immunology* / Q000517:prevention & control*; D008297:Male; D012307:Risk Factors