Genealogical trees, coalescent theory and the analysis of genetic polymorphisms.
Improvements in genotyping technologies have led to the increased use of genetic polymorphism for inference about population phenomena, such as migration and selection. Such inference presents a challenge, because polymorphism data reflect a unique, complex, non-repeatable evolutionary history. Traditional analysis methods do not take this into account. A stochastic process known as the 'coalescent' presents a coherent statistical framework for analysis of genetic polymorphisms.
Rosenberg
Noah A
NA
Program in Molecular and Computational Biology, University of Southern California, 835 West 37th Street, SHS172, Los Angeles, California 90089-1340, USA.
Nordborg
Magnus
M
D000818:Animals; D019143:Evolution, Molecular; D005828:Genetics, Population; D006801:Humans; D010375:Pedigree; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D013269:Stochastic Processes