[Seasonal changes in tumor necrosis factor production in hibernating animals in normal conditions and under the effects of electromagnetic and ionizing radiation].
Production of tumor necrosis factor (TNF) has been investigated in peritoneal macrophages and splenic T cells of Arctic Yakutian ground squirrel (Citellus Undulatus Pallas) upon in vitro action of electromagnetic and ionizing radiation during annual cycle. The significant activation of TNF production in the cells of awaken ground squirrels in winter and increasing level of the lymphokine production at spring-summer period has been indicated. The level of TNF production in splenic T cells was not changed during whole year. The electromagnetic radiation (EMR) of low intensity (8.15-18 GHz, 1 microW/cm2) induced an augmentation of both secretory and proliferative activity in TNF-producing cells. Ionizing radiation suppressed T cell proliferation, but the doses 2 and 5 Gy resulted in a significant stimulation of TNF production in T cells and macrophages.
Ogaĭ
V B
VB
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290 Russia. ogay@mail.icb.psn.ru
Novoselova
E G
EG
Makar
V R
VR
Kolaeva
S G
SG
D000818:Animals; D002478:Cells, Cultured / Q000528:radiation effects; D003627:Data Interpretation, Statistical; D055590:Electromagnetic Phenomena; D005260:Female; D006605:Hibernation / Q000502:physiology*; D017737:Macrophages, Peritoneal / Q000528:radiation effects*; D008297:Male; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D012589:Sciuridae / Q000502:physiology*; D012621:Seasons; D013154:Spleen / Q000528:radiation effects; D013601:T-Lymphocytes / Q000528:radiation effects*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D014409:Tumor Necrosis Factor-alpha