Spermine alkaloids from Albizia adinocephala with activity against Plasmodium falciparum plasmepsin II.
Crude MeOH extracts from the stem bark and leaves of a Panamanian specimen of Albizia adinocephala (Leguminosae) were found to inhibit the malarial enzyme plasmepsin II. Bioassay guided fractionation led to the isolation of two new bioactive spermine alkaloids, budmunchiamines L4 and L5.
Ovenden
Simon P B
SP
Centre for Natural Product Research, 59A Science Park Drive, The Fleming, Singapore Science Park, 118240, Singapore.
Cao
Shugeng
S
Leong
Chungyan
C
Flotow
Horst
H
Gupta
Mahabir P
MP
Buss
Antony D
AD
Butler
Mark S
MS
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D016282:Aspartic Acid Endopeptidases / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D007887:Fabaceae / Q000737:chemistry*; D015394:Molecular Structure; D018514:Plant Structures / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000201:enzymology*; D015800:Protozoan Proteins; D013055:Spectrophotometry, Infrared; D013096:Spermine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000470:Alkaloids; D000962:Antimalarials; D015800:Protozoan Proteins; D013096:Spermine; D016282:Aspartic Acid Endopeptidases; C100637:plasmepsin II