Nasal glioma or nasal glial heterotopia? Morphological, immunohistochemical and ultrastructural study of two cases.
The term nasal glioma has been used to describe a congenital benign tumor of the nasal region containing neural tissue. The nature of these lesions remains open to controversy, because of the different locations of the heterotopic neural tissue involved, the deficient development of the bony structures and the persistence or not of the structural relations with the central nervous system. More recent terms define these lesions as ectopic nervous tissue. A clinical, morphological, ultrastructural and immunohistochemical study is made of two cases of nasal glioma, one associated with agenesis of the corpus callosum. In this case, the mother had been treated with clomiphene. In such cases, morphological and immunohistochemical findings support that "nasal glioma" remain valid as a descriptive term defining a congenital benign tumor composed of heterotopic neural tissue within the nasal region and covered by skin, that may recur following incomplete surgical resection.
Cerdá-Nicolás
M
M
Department of Pathology, Clinical Hospital, University of Valencia, Spain. jose.m.cerda@uv.es
Sanchez Fernandez de Sevilla
C
C
Lopez-Ginés
C
C
Peydro-Olaya
A
A
Llombart-Bosch
A
A
D000015:Abnormalities, Multiple / Q000473:pathology; D000328:Adult; D061085:Agenesis of Corpus Callosum; D000858:Anovulation / Q000188:drug therapy; D014408:Biomarkers, Tumor / Q000032:analysis; D002828:Choristoma / Q000473:pathology*; D002996:Clomiphene / Q000008:administration & dosage / Q000009:adverse effects; D003337:Corpus Callosum / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005313:Fetal Death / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005910:Glioma / Q000151:congenital / Q000473:pathology*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008854:Microscopy, Electron; D009457:Neuroglia; D009668:Nose Diseases / Q000473:pathology*; D009669:Nose Neoplasms / Q000151:congenital / Q000473:pathology*; D011247:Pregnancy
D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D002996:Clomiphene