New aspects of the tolerance of the antiseptic povidone-iodine in different ex vivo models.
Investigating new possibilities for the application of 1% (v/v) iodophors, povidone-iodine (PVP-I) was better tolerated in the HET-CAM or explant test than 1% (w/v) silver nitrate or tetracycline. After application to the eye, at least 2.6% of used iodine were adsorbed. Therefore PVP-I is more effective than silver nitrate or erythromycin, meaning a possible alternative for the prevention of ophthalmia neonatorum. PVP-I is more active against methicillin-resistant Staphylococcus aureus (MRSA) in a human ex vivo skin model, which results in a complete eradication of S. aureus in the nasal cavity of volunteers after 2 daily applications and will be better tolerated by human nasal cilial epithelium than chlorhexidine. Having the same clinical tolerance as mupirocin, PVP-I is a useful alternative for the antiseptic therapy of germ carriers of MRSA. The synthesis of proteoglycans in articular cartilage of bovine sesamoid bones was increased after application of 5% (v/v) PVP-I without any increase in catabolism revealing possibilities for the use as irrigation solution in the joint.
Kramer
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A
Institute of Hygiene and Environmental Medicine, Ernst Moritz Arndt University, Greifswald, Germany. kramer@rz.uni-greifswald.de
Below
H
H
Behrens-Baumann
W
W
Müller
G
G
Rudolph
P
P
Reimer
K
K
D000482:Allantois / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002358:Cartilage, Articular / Q000187:drug effects / Q000378:metabolism; D002417:Cattle; D002823:Chorion / Q000187:drug effects / Q000378:metabolism; D005123:Eye / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D016106:Methicillin Resistance; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism; D011206:Povidone-Iodine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011509:Proteoglycans / Q000096:biosynthesis; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D013211:Staphylococcus aureus / Q000187:drug effects; D013640:Tarsal Joints
D000891:Anti-Infective Agents, Local; D011509:Proteoglycans; D011206:Povidone-Iodine