title: Toxicity and biodegradation of diamines.
abstract: Phytotoxicity and cytotoxicity of 2,4-diaminotoluene (2,4-D), 4,4'-methylenedianiline (4,4-D), and 1,6-hexanediamine (1,6-D) were investigated by observing the germination of young radish seeds and the viability of HeLa cells, respectively. 2,4-D showed the highest, 4,4-D intermediate, and 1,6-D lowest cytotoxicity. However, the phytotoxicity decreased in the order of 4,4-D > 2,4-D > 1,6-D. Contrary to the results previously reported, in the modified Sturm test the activated sludge degraded 2,4-D and 4,4-D as well as 1,6-D without any pre-acclimation. Ochrobacterium antropi was isolated for degradation of 2,4-D and 4,4-D and Pseudomonas citronellolis for 1,6-D degradation. Thielevia sp. was isolated as 2,4-D degrading fungus and Aspergillus sp. as 4,4-D and 1,6-D degrading fungus. The fungi degraded the diamines faster than the bacteria.
authors: Department of Biology, Sangmyung University, Seoul, Korea. mnkim@sangmyung.ac.kr
authors: Mal-Nam
authors: MN
authors: Kim
authors: Ji-Chul
authors: JC
authors: Jang
authors: Ik-Mo
authors: IM
authors: Lee
authors: Han-Sup
authors: HS
authors: Lee
authors: Jin-San
authors: JS
authors: Yoon
mesh_terms: D000814:Aniline Compounds / Q000378:metabolism / Q000633:toxicity; D001230:Aspergillus / Q000302:isolation & purification / Q000378:metabolism*; D001673:Biodegradation, Environmental; D002470:Cell Survival / Q000187:drug effects; D003959:Diamines / Q000378:metabolism* / Q000633:toxicity*; D018525:Germination / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D020621:Ochrobactrum anthropi / Q000302:isolation & purification / Q000378:metabolism*; D010655:Phenylenediamines / Q000378:metabolism / Q000633:toxicity; D011549:Pseudomonas / Q000302:isolation & purification / Q000378:metabolism*; D031224:Raphanus / Q000187:drug effects / Q000502:physiology; D012639:Seeds / Q000187:drug effects / Q000502:physiology; D018675:Toxicity Tests; D001559:Benzhydryl Compounds
chemical_list: D000814:Aniline Compounds; D003959:Diamines; D010655:Phenylenediamines; C009505:4,4'-diaminodiphenylmethane; D001559:Benzhydryl Compounds; C010914:2,4-diaminotoluene; C007297:1,6-diaminohexane