[Interaction between HTLV-1 transcription activator tax and Taxreb107].
Tax is a transcription activator encoded by human T-cell leukemia virus (HTLV)-1. Ribosomal protein L6 was also defined as Taxreb107 (Tax responsible element binding protein 107) for its activity of binding to the long terminal repeats of HTLV-1. To investigate the relationship between Tax and Taxreb107/RpL6, yeast two hybrid and GST pull-down assays were used. Results suggest that Tax can interact with Taxreb107/RpL6 directly and Taxreb107/RpL6 may regulate the function of Tax in HTLV-1 proliferation.
Yang
Xi
X
Department of Medical Genetics and Developmental Biology, The Fourth Military Medical University, Xi'an 710032, China.
Wang
Ji-Shu
JS
Han
Hua
H
D000818:Animals; D018076:DNA, Complementary / Q000235:genetics; D016356:Gene Products, tax / Q000235:genetics / Q000378:metabolism*; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism; D015368:Human T-lymphotropic virus 1 / Q000378:metabolism*; D006801:Humans; D051379:Mice; D011485:Protein Binding; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D012269:Ribosomal Proteins / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D020798:Two-Hybrid System Techniques
D018076:DNA, Complementary; D016356:Gene Products, tax; D011993:Recombinant Fusion Proteins; D012269:Ribosomal Proteins; C031249:ribosomal protein L6; D005982:Glutathione Transferase