title: A randomized, double blind, placebo-controlled study to investigate the use of conscious sedation in conjunction with paracervical block for reducing pain in termination of first trimester pregnancy by suction evacuation.
abstract: BACKGROUND
  This study evaluated the role of conscious sedation in pain relief during termination of first trimester pregnancy by suction evacuation (SE) under local anaesthesia.
  
  
  METHODS
  A hundred women undergoing SE before 12 weeks gestation were randomized by computer using the sealed envelope method to receive placebo (saline) or conscious sedation (2 mg midazolam and 25 microg fentanyl) i.v. 5 min before cervical dilatation. Paracervical block was given to all patients, 2 min later. Pain scores during and after SE, post-operative side-effects and satisfaction level were compared.
  
  
  RESULTS
  No statistically significant differences in pain scores were found between the two groups. Post-operative side-effects such as dizziness (P = 0.015) and drowsiness (P < 0.001) were significantly more severe in the conscious sedation group. However, patients in the conscious sedation group reported better satisfaction levels than the control group (P = 0.003).
  
  
  CONCLUSIONS
  The use of conscious sedation significantly improved patient satisfaction during termination of first trimester pregnancy by SE under local anaesthesia, despite a lack of improvement in pain relief and the presence of increased severe dizziness/drowsiness in the post-operative period.
authors: Department of Obstetrics and Gynaecology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China. wongcyg@yahoo.com
authors: C Y G
authors: CY
authors: Wong
authors: E H Y
authors: EH
authors: Ng
authors: S W
authors: SW
authors: Ngai
authors: P C
authors: PC
authors: Ho
mesh_terms: D000028:Abortion, Induced / Q000379:methods*; D000773:Anesthesia, Obstetrical; D016292:Procedural Sedation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D010166:Palliative Care / Q000379:methods*; D010919:Placebos; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D013396:Suction
chemical_list: D010919:Placebos