title: Peak systolic velocity Doppler index reflects most appropriately the dynamic time course of intact cerebral autoregulation.
abstract: BACKGROUND
  Transcranial Doppler sonography measures blood flow velocity in basal cerebral vessels with high accuracy and time resolution. Dynamic blood flow tests were used to investigate functional integrity of the cerebral autoregulation (CA) mechanism. It is known from cortical activation studies that velocity indices differ in their appropriateness to measure changes in blood flow velocity. We aimed to compare the peak systolic, end diastolic and time-averaged mean flow velocity indices for their use in measuring the effectiveness of the CA mechanism.
  
  
  METHODS
  We performed the leg cuff test to induce in 15 healthy volunteers (aged 24.8 +/- 0.4 years, 9 males) CA due to a sudden arterial blood pressure decrease. Data from the middle and posterior cerebral arteries were measured continuously with transcranial Doppler ultrasound, and the arterial blood pressure with a noninvasive photoplethysmographic method. After transforming all variables to relative changes, velocity-pressure diagrams were calculated for each velocity-pressure index. Additionally, we calculated the autoregulation index.
  
  
  RESULTS
  The step decrease in arterial blood pressure resulted in an initial drop, which is followed by a rapid recovery of cerebral blood flow velocity. The autoregulation index was 5.5 +/- 1. Efficacy of CA is illustrated more accurately by peak systolic velocity-pressure curves, which lie continuously above a passive velocity-pressure relationship assuming CA to be absent.
  
  
  CONCLUSIONS
  Our data show peak systolic blood flow velocity index to be most accurate for measuring effectiveness of the dynamic CA mechanism. No differences in the CA were found between the vascular territory of the middle and posterior cerebral arteries.
authors: Department of Neurology, Faculty of Medicine, Justus Liebig University of Giessen, Germany.
authors: B
authors: B
authors: Rosengarten
authors: M
authors: M
authors: Kaps
mesh_terms: D000328:Adult; D016477:Artifacts; D001783:Blood Flow Velocity / Q000502:physiology*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging* / Q000502:physiology*; D003971:Diastole / Q000502:physiology; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D012016:Reference Values; D013599:Systole / Q000502:physiology; D013997:Time Factors; D017585:Ultrasonography, Doppler, Transcranial