title: Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta(1).
abstract: A novel human galectin cDNA (PPL13) was isolated by screening a human 18-week fetal brain library. The mRNA was predominantly expressed in placenta, while the expression of it was not or barely detectable in heart, brain, lung, liver, skeletal muscle, kidney, and pancreas by Northern blot. COS-7 cells transfected with cDNA encoding human PPL13 sequestered the protein in nuclei although it lacked any known nuclear localization signal. STS of Unigene Hs. 24236 placed the cDNA to human chromosome 19q13.2.
authors: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 200433, Shanghai, PR China.
authors: Quan-Sheng
authors: QS
authors: Yang
authors: Kang
authors: K
authors: Ying
authors: Hong-Ling
authors: HL
authors: Yuan
authors: Jin-Zhong
authors: JZ
authors: Chen
authors: Xian-Fang
authors: XF
authors: Meng
authors: Zhao
authors: Z
authors: Wang
authors: Yi
authors: Y
authors: Xie
authors: Yu-Min
authors: YM
authors: Mao
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000196:embryology / Q000378:metabolism; D019556:COS Cells; D002467:Cell Nucleus / Q000378:metabolism; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry / Q000302:isolation & purification; D005260:Female; D037161:Galectins; D015723:Gene Library; D006801:Humans; D008969:Molecular Sequence Data; D010920:Placenta / Q000378:metabolism*; D011257:Pregnancy Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment; D014162:Transfection
chemical_list: D018076:DNA, Complementary; D037161:Galectins; C038195:LGALS13 protein, human; D011257:Pregnancy Proteins