13C-NMR study of 4-azasteroids in solution and solid state.
A group of biologically active 4-azasteroids was studied by 13C-NMR spectroscopy in solution and in the solid phase. A full assignment of signals in the spectra of samples in chloroform was performed for thirteen 4-azasteroids using two-dimensional techniques. Substituent and steric effects of a nitrogen atom, and their influence on chemical shifts of the neighboring carbon atoms are discussed. CP MAS spectra were obtained for five 4-azasteroids including finasteride. The spectra confirmed polymorphism of the latter compound. In addition to the polymorphic forms that are already known, a new molecular complex of finasteride with dioxane is reported.
Morzycki
Jacek W
JW
University of Bialystok, Institute of Chemistry, al. Pilsudskiego 11/4, Poland. morzycki@noc.uwb.edu.pl
Wawer
Iwona
I
Gryszkiewicz
Agnieszka
A
Maj
Jadwiga
J
Siergiejczyk
Leszek
L
Zaworska
Alicja
A
D001378:Azasteroids / Q000032:analysis / Q000737:chemistry*; D002247:Carbon Isotopes; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012996:Solutions
D001378:Azasteroids; D002247:Carbon Isotopes; D012996:Solutions