Pathways of apoptosis in lymphocyte development, homeostasis, and disease.
Apoptosis plays a critical role in lymphocyte development and homeostasis. Enhanced lymphocyte apoptosis can cause immunodeficiency through cell loss. Conversely, inhibition of apoptosis can lead to the development of autoimmunity or lymphoma. Two major pathways contribute to the regulation of lymphocyte cell death, death-by-neglect and death-by-instruction.
Rathmell
Jeffrey C
JC
Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Thompson
Craig B
CB
D000818:Animals; D017209:Apoptosis; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D006706:Homeostasis; D006801:Humans; D007156:Immunologic Memory; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008928:Mitochondria / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D015398:Signal Transduction
D011518:Proto-Oncogene Proteins