title: Efficacy of microfiltration in decreasing propofol-induced pain.
abstract: In a randomised, double-blinded, two-centre trial we evaluated the effect of a microbiological filter (Supor, Pall Life Sciences) on propofol injection pain. We studied 336 unpremedicated adult patients, who graded pain experienced during induction of anaesthesia with propofol on a 4-point verbal rating scale. Use of the microfilter reduced both the incidence and severity of propofol injection pain (p < 0.001). Incidence of severe pain in the filter group was 2.4% compared with 16.6% in the control group. Overall, 33.7% in the filter group experienced pain compared with 62.1% in the control group. A microbiological filter may provide a non-pharmacological alternative to a lidocaine/propofol mixture for reducing injection pain. It would also reduce the risk of any glass and bacterial contamination.
authors: Department of Anaesthesia, Royal Devon and Exeter Hospital, Exeter UK.
authors: A F
authors: AF
authors: Davies
authors: B
authors: B
authors: Vadodaria
authors: B
authors: B
authors: Hopwood
authors: T
authors: T
authors: Dexter
authors: D
authors: D
authors: Conn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D005260:Female; D005898:Glass; D006801:Humans; D007275:Injections, Intravenous; D007509:Irritants; D008297:Male; D008851:Micropore Filters; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement; D015742:Propofol / Q000009:adverse effects*; D012828:Silicones
chemical_list: D018686:Anesthetics, Intravenous; D007509:Irritants; D012828:Silicones; D015742:Propofol