Protein kinase C activation by iridal type triterpenoids.
Eleven iridal type triterpenoids from Iris tectorum and Belamcanda chinensis were examined for protein kinase C (PKC) activation and binding activity to PKC. Among the tested compounds, nine iridals showed dose-dependent activities, and a mutual relation between the two activities was also observed. 28-Deacetylbelamcandal, which has been found to be a new class 12-O-tetradecanoylphorbol 13-acetate type tumor promoter, showed the most potent activity in both tests. The structural requirements of the iridals inducing these activities were as follows: 1) a hydrophobic side-chain, 2) an E-methylidene aldehyde group at the C-1 position, and 3) a hydroxyl group at the C-26 position.
Takahashi
Kunihiko
K
Saitama Institute of Public Health, Japan. k-takahashi@ma.neweb.ne.jp
Suzuki
Sumiko
S
Hano
Yoshio
Y
Nomura
Taro
T
D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D027621:Iridaceae / Q000737:chemistry / Q000201:enzymology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D011493:Protein Kinase C / Q000737:chemistry / Q000378:metabolism*; D027343:Rhizome / Q000737:chemistry / Q000201:enzymology*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
D010936:Plant Extracts; D014315:Triterpenes; D011493:Protein Kinase C