title: Reevaluation of the role of HWP1 in systemic candidiasis by use of Candida albicans strains with selectable marker URA3 targeted to the ENO1 locus.
abstract: Previous evaluation of HWP1 in systemic candidiasis in CBA/J mice was done with Candida albicans strains with differing genetic locations of URA3 as a result of Ura-blaster mutagenesis. In this study, the presence of HWP1 and the location of URA3 contributed to the severity of murine systemic candidiasis in BALB/c mice.
authors: Department of Molecular Virology, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA. sundstrom.1@osu.edu
authors: Paula
authors: P
authors: Sundstrom
authors: Jim E
authors: JE
authors: Cutler
authors: Janet F
authors: JF
authors: Staab
mesh_terms: D000818:Animals; D015415:Biomarkers; D002176:Candida albicans / Q000235:genetics / Q000472:pathogenicity; D002177:Candidiasis / Q000382:microbiology* / Q000401:mortality / Q000503:physiopathology; D004195:Disease Models, Animal; D005656:Fungal Proteins / Q000235:genetics*; D005800:Genes, Fungal; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010751:Phosphopyruvate Hydratase / Q000235:genetics*
chemical_list: D015415:Biomarkers; D005656:Fungal Proteins; C118102:HWP1 protein, Candida albicans; D008562:Membrane Glycoproteins; C457379:Eno1 protein, mouse; D010751:Phosphopyruvate Hydratase