First direct lithiation of 2-pyridylpiperazine on solid phase.
[reaction: see text] The first direct lithiation of a pyridine derivative on solid phase has been realized. Metalation of polymer-bound 2-pyridylpiperazine with the BuLi-LiDMAE reagent followed by electrophilic quenching and subsequent cleavage provided a range of new useful C-6 substituted 2-piperazinylpyridines.
Gros
Philippe
P
Synthèse Organique et Réactivité, UMR CNRS-UHP 7565, Faculté des Sciences, Université Henri Poincaré-Nancy I, BP 239, 54506, Vandoeuvre-Lès-Nancy, France. philippe.gros@sor.uhp-nancy.fr
Louërat
Frédéric
F
Fort
Yves
Y
D003432:Cross-Linking Reagents; D006571:Heterocyclic Compounds / Q000138:chemical synthesis; D007202:Indicators and Reagents; D008094:Lithium / Q000737:chemistry*; D010879:Piperazines / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
D003432:Cross-Linking Reagents; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D010879:Piperazines; D011725:Pyridines; C458160:2-pyridylpiperazine; D008094:Lithium