Hematological and antifungal properties of temporin A and a cecropin A-temporin A hybrid.
Temporin A (TA) and a cecropin A-temporin A hybrid peptide (CATA) were synthesized and assayed for their hemolytic, anticoagulant, and antifungal properties. CATA retains significant antifungal activity, is less hemolytic than TA, and inhibits blood coagulation. These results recommend further studies of the biological activities of CATA.
Wade
D
D
Peptide Laboratory, Haartman Institute, Helsinki University, Finland. wade@cc.helsinki.fi
Silveira
A
A
Rollins-Smith
L
L
Bergman
T
T
Silberring
J
J
Lankinen
H
H
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D004912:Erythrocytes / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D008969:Molecular Sequence Data; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry / Q000494:pharmacology*; D011516:Prothrombin / Q000737:chemistry / Q000494:pharmacology; D013925:Thromboplastin / Q000737:chemistry / Q000494:pharmacology
D000596:Amino Acids; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; D010455:Peptides; D011506:Proteins; C104501:temporin; C031161:cecropin A; D011516:Prothrombin; D013925:Thromboplastin