title: Association between Helicobacter felis-induced gastritis and elevated glycated hemoglobin levels in a mouse model of type 1 diabetes.
abstract: Helicobacter pylori infection has been described in association with increases in glycated hemoglobin (HbA(1c)) levels in patients with type 1 diabetes. The purpose of the present study was to use an animal model of Helicobacter infection to test, under controlled conditions, the hypothesis that infection is associated with high HbA(1c) levels. Diabetes was induced in C57BL/6 mice by administration of streptozotocin, and the mice were orally inoculated with H. felis. Six weeks after inoculation, infected mice (n=10) showed gastritis scores significantly greater (P=.01) than those of uninfected mice (n=10). HbA(1c) levels were significantly higher in infected mice with gastritis (11.6%; n=6) than in infected mice without gastritis (8.4%; n=4) or uninfected mice (7.6%; n=10). It was concluded that gastritis induced by H. felis is associated with increased HbA(1c) levels in the mouse model of streptozotocin-induced diabetes.
authors: Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA.
authors: Nuthapong
authors: N
authors: Ukarapol
authors: Rodolfo E
authors: RE
authors: Bégué
authors: James
authors: J
authors: Hempe
authors: Hernán
authors: H
authors: Correa
authors: Ricardo
authors: R
authors: Gómez
authors: Alfonso
authors: A
authors: Vargas
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005756:Gastritis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006442:Glycated Hemoglobin / Q000032:analysis / Q000378:metabolism*; D016998:Helicobacter; D016481:Helicobacter Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000276:immunology
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin