Latent adenovirus infection in COPD.
We have concentrated on the adenovirus as the source of the heightened inflammatory response of the lungs of patients with COPD. We have concentrated in particular on the responses to agents such as lipopolysaccharides and environmental particulates that contaminate the air we breathe, and we have accumulated evidence that the E1A gene of this virus could be the key player in this process. As other intracellular pathogens such as Chlamydia pneumoniae have recently been implicated in the pathogenesis of COPD, our studies on the adenovirus E1A could serve as the model for investigating the interaction between host and extrinsic factors in the chronic progression of this debilitating lung disease.
Hayashi
Shizu
S
McDonald Research Laboratory, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6. shayashi@mrl.ubc.ca
D000256:Adenoviridae / Q000502:physiology; D000257:Adenoviridae Infections / Q000150:complications*; D017500:Adenovirus E1A Proteins / Q000378:metabolism; D000818:Animals; D004279:DNA, Viral / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D029424:Pulmonary Disease, Chronic Obstructive / Q000821:virology*; D020545:Respiratory Mucosa / Q000821:virology; D017735:Virus Latency
D017500:Adenovirus E1A Proteins; D004279:DNA, Viral