title: NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15).
abstract: Fusion between the NUP98 and NSD3 genes in a patient with acute myeloid leukemia associated with t(8;11)(p11.2;p15), is reported for the first time. The t(8;11)(p11.2;p15) was identified by classical cytogenetics. Fluorescence in situ hybridization (FISH) analysis revealed a split signal with a mix of BAC 118H17 and 290A12, indicating the translocation disrupted NUP98. FISH restriction at 8p11-12 showed a split of BAC 350N15. Molecular investigations into candidate genes in this BAC showed the NUP98 fusion partner at 8p11.2 was the NSD3 gene. To date the NSD3 gene has never been implicated in hematologic malignancies.
authors: Hematology and Bone Marrow Transplantation Unit, University of Perugia, Italy.
authors: Roberto
authors: R
authors: Rosati
authors: Roberta
authors: R
authors: La Starza
authors: Angelo
authors: A
authors: Veronese
authors: Ana
authors: A
authors: Aventin
authors: Christine
authors: C
authors: Schwienbacher
authors: Teresa
authors: T
authors: Vallespi
authors: Massimo
authors: M
authors: Negrini
authors: Massimo F
authors: MF
authors: Martelli
authors: Cristina
authors: C
authors: Mecucci
mesh_terms: D000208:Acute Disease; D000368:Aged; D000595:Amino Acid Sequence; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D002898:Chromosomes, Human, Pair 8; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D028861:Nuclear Pore Complex Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D012334:RNA, Neoplasm / Q000032:analysis; D014178:Translocation, Genetic
chemical_list: D002352:Carrier Proteins; D028861:Nuclear Pore Complex Proteins; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D012334:RNA, Neoplasm; C093350:nuclear pore complex protein 98; D011495:Histone-Lysine N-Methyltransferase; C432968:NSD3 protein, human