Left ventricular diastolic function is related to glucose in a middle-aged population.
OBJECTIVE
To examine the relation between left ventricular (LV) diastolic function and glucose metabolism in individuals without previously diagnosed diabetes mellitus.


METHODS
A cross-sectional population-based study.


METHODS
A university hospital.


METHODS
Thirty-five men and women 56-58 years of age without previously diagnosed diabetes or heart disease.


METHODS
Left ventricular diastolic function assessed by pulsed Doppler tissue imaging and its relation to fasting plasma glucose, glucose postload and glycated haemoglobin. LV diastolic function was determined by measuring early diastolic filling peak velocity (Em wave cm s-1), late diastolic filling peak velocity (Am wave cm s-1) and their ratio Em/Am.


RESULTS
Peak Em velocity, peak Am velocity and their ratio Em/Am correlated with fasting plasma glucose (r=-0.42, P=0.01; r=0.47, P=0.04 and r=-0.53, P=0.001, respectively). There was a correlation between peak Em velocity, the ratio of Em/Am and glycated haemoglobin. LV diastolic function was also related to glucose postload.


CONCLUSIONS
Left ventricular diastolic function is related to concentrations of fasting plasma glucose, glucose postload and glycated haemoglobin even below the threshold of diabetes. This indicates that glucose concentrations already in the upper end of the normal range has negative impact on cardiac function.
Holzmann
M
M
Department of Cardiology, Karolinska Institute at Karolinska Hospital, Stockholm, Sweden. martin.holzmann@ks.se
Olsson
A
A
Johansson
J
J
Jensen-Urstad
M
M
D001786:Blood Glucose / Q000032:analysis*; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000502:physiology
D001786:Blood Glucose; D006442:Glycated Hemoglobin