title: Synthetic musks in the environment. Part 2: Enantioselective transformation of the polycyclic musk fragrances HHCB, AHTN, AHDI, and ATII in freshwater fish.
abstract: A method for the enantioselective separation of the chiral polycyclic musks HHCB, AHTN, AHDI, and ATII is presented. Eighteen fish samples (rudd, tench, crucian carp, eel) and one pooled zebra mussel sample from the pond of a municipal sewage treatment plant were investigated with regard to their concentrations and the enantiomeric ratios (ERs) of polycyclic musks. In addition, three water samples taken at the effluent of the sewage plant, as well as two water samples and two series of semipermeable membrane devices (SPMDs) consisting of six samples each from the pond were included in the present study. This comprehensive data set allowed a reliable evaluation of species-dependent metabolization processes. The pattern of the polycyclic musks in the chromatograms obtained by enantioselective gas chromatography seems to be typical of each species, like a fingerprint. The highest deviations from the racemic ER were found for trans-HHCB and trans-ATII in crucian carp with values of or below 0.1. Calculations showed that enantioselective transformation seems to be the most important process, resulting in the observed lower concentrations in crucian carp compared to tench. Consequences for a risk assessment are discussed.
authors: Dr. Wiertz, Dipl.-Chem. Eggert, Dr. Jörissen GmbH Analytical Laboratory (WEJ), Stenzelring 14b, D-21107 Hamburg, Germany.
authors: R
authors: R
authors: Gatermann
authors: S
authors: S
authors: Biselli
authors: H
authors: H
authors: Hühnerfuss
authors: G G
authors: GG
authors: Rimkus
authors: S
authors: S
authors: Franke
authors: M
authors: M
authors: Hecker
authors: R
authors: R
authors: Kallenborn
authors: L
authors: L
authors: Karbe
authors: W A
authors: WA
authors: König
mesh_terms: D000818:Animals; D001578:Benzopyrans / Q000493:pharmacokinetics*; D049872:Bivalvia / Q000378:metabolism*; D004784:Environmental Monitoring; D005399:Fishes / Q000378:metabolism*; D005618:Fresh Water / Q000032:analysis; D005858:Germany; D007189:Indans / Q000493:pharmacokinetics*; D010476:Perfume; D012722:Sewage / Q000032:analysis; D013045:Species Specificity; D013237:Stereoisomerism; D013764:Tetrahydronaphthalenes / Q000493:pharmacokinetics*; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics*
chemical_list: C110695:5-acetyl-1,1,2,6-tetramethyl-3-isopropylindane; D001578:Benzopyrans; D007189:Indans; D010476:Perfume; D012722:Sewage; D013764:Tetrahydronaphthalenes; D014874:Water Pollutants, Chemical; C033119:galaxolide; C033117:phantolid; C033116:acetyl methyl tetramethyl tetralin