Comparative assessment of large-scale data sets of protein-protein interactions.
Comprehensive protein protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions.
von Mering
Christian
C
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.
Krause
Roland
R
Snel
Berend
B
Cornell
Michael
M
Oliver
Stephen G
SG
Fields
Stanley
S
Bork
Peer
P
D015982:Bias; D016208:Databases, Factual; D005189:False Positive Reactions; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D013058:Mass Spectrometry; D011485:Protein Binding; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D012015:Reference Standards; D012680:Sensitivity and Specificity; D020798:Two-Hybrid System Techniques
D005656:Fungal Proteins; D011506:Proteins; D012333:RNA, Messenger