title: Modulation of the host response in periodontal therapy.
abstract: This paper was prepared by the Research, Science, and Therapy Committee of the American Academy of Periodontology to provide the dental profession an overview of current and potential methods to modulate the host response in the treatment of periodontal diseases. Specifically, it discusses components of periodontal disease pathogenesis (i.e., immune and inflammatory responses, excessive production of matrix metalloproteinases and arachidonic acid metabolites, and regulation of bone metabolism) and their modulation.
authors: Richard J
authors: RJ
authors: Oringer
mesh_terms: D000539:Alveolar Process / Q000187:drug effects / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001095:Arachidonic Acids / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology; D018441:Biofilms; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D016207:Cytokines / Q000276:immunology; D012534:Dental Scaling; D004164:Diphosphonates / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology; D008084:Lipoxygenase / Q000276:immunology; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use; D020782:Matrix Metalloproteinases / Q000276:immunology; D010510:Periodontal Diseases / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D011451:Prostaglandin-Endoperoxide Synthases / Q000276:immunology; D016745:Root Planing
chemical_list: D000900:Anti-Bacterial Agents; D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D016207:Cytokines; D004164:Diphosphonates; D018836:Inflammation Mediators; D016859:Lipoxygenase Inhibitors; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D020782:Matrix Metalloproteinases; D004318:Doxycycline