title: Association of 5-HT(2A) receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk.
abstract: BACKGROUND
  The implication of serotonin in suicide and affective disease explains why the 5-HT(2A) receptor gene has been proposed as a candidate gene in these disorders, although with conflicting results.
  
  
  METHODS
  We analysed the distribution of the 5-HT(2A)-1438A/G genetic polymorphism in 192 patients with major affective disorder (127 bipolar disorders and 65 unipolar disorders) compared to 142 healthy control subjects.
  
  
  RESULTS
  We found a higher frequency of the A allele in affected patients than in control subjects (p =.034), this difference being particularly striking for the subgroup of patients with type I bipolar disorder (p =.015). Patients with no personal and/or familial history of suicide attempts mainly accounted for the excess of the A allele in affected patients.
  
  
  CONCLUSIONS
  The association detected in this study suggests that the 5-HT(2A) receptor gene may play a role in the genetic susceptibility to bipolar disorder, through a specific subgroup of bipolar type I patients with lower risk of suicidal behavior.
authors: Hôpital Mignot, Service de Psychiatrie, Le Chesney, France.
authors: Béatrice
authors: B
authors: Bonnier
authors: Philip
authors: P
authors: Gorwood
authors: Michel
authors: M
authors: Hamon
authors: Yves
authors: Y
authors: Sarfati
authors: Claudette
authors: C
authors: Boni
authors: Marie-Christine
authors: MC
authors: Hardy-Bayle
mesh_terms: D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology*; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000235:genetics* / Q000523:psychology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D012306:Risk; D013405:Suicide / Q000523:psychology*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin