[Immune status of BALB/c mice and rubella virus JR23 strain infection of central nervous system].
BACKGROUND
To investigate the relationship between immune status and rubella virus (RV) infection of central nervous system (CNS).


METHODS
BALB/c mice were given dexamethaxone and cytoxan before RV JR23 strain infection. Immune functions and RV invasion to CNS were assayed at 21 days postinfection via abdominal cavity and their relationship was analyzed.


RESULTS
T cell functions of cytoxan group were obviously worse than those of other groups (P <0.05) by MTT method. Infection rates of dexamethaxone and cytoxan and the group without any intervention were 60%, 90% and 50% (P >0.05), respectively. Cellular immune functions of the mice with CNS infection were obviously worse than those of the mice without CNS infection (P <0.001). Specific antibodies (Ab) were assayed in all groups with ELISA and the results showed that there were no significant differences among groups (P >0.05), neither between the groups with and without CNS infections.


CONCLUSIONS
RV infection of CNS may relate to cellular immune status before specific antibody was produced in the body.
Wang
Zhiyu
Z
Department of Virology, Shandong Medical University, Jinan 250012, China.
Yao
Ping
P
Song
Yanyan
Y
Xu
Hongzhi
H
Wang
Guiting
G
Liu
Yanxun
Y
D000818:Animals; D000918:Antibody Specificity; D002494:Central Nervous System Infections / Q000276:immunology* / Q000821:virology; D005260:Female; D007111:Immunity, Cellular; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012409:Rubella / Q000276:immunology*; D012412:Rubella virus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology