title: Diarrhea-inducing activity of avian rotavirus NSP4 glycoproteins, which differ greatly from mammalian rotavirus NSP4 glycoproteins in deduced amino acid sequence in suckling mice.
abstract: Avian rotavirus NSP4 glycoproteins expressed in Escherichia coli acted as enterotoxins in suckling mice, as did mammalian rotavirus NSP4 glycoproteins, despite great differences in the amino acid sequences. The enterotoxin domain of PO-13 NSP4 exists in amino acid residues 109 to 135, a region similar to that reported in SA11 NSP4.
authors: Department of Veterinary Public Health, Faculty of Agriculture, Gifu University, Gifu 501-1193, Japan.
authors: Yoshio
authors: Y
authors: Mori
authors: Mohammed Ali
authors: MA
authors: Borgan
authors: Naoto
authors: N
authors: Ito
authors: Makoto
authors: M
authors: Sugiyama
authors: Nobuyuki
authors: N
authors: Minamoto
mesh_terms: D000596:Amino Acids; D000818:Animals; D001665:Binding Sites; D001715:Bird Diseases / Q000821:virology; D002460:Cell Line; D002645:Chickens / Q000821:virology; D010856:Columbidae / Q000821:virology; D003967:Diarrhea / Q000821:virology*; D004768:Enterotoxins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D008253:Macaca mulatta; D051379:Mice; D008807:Mice, Inbred BALB C; D030101:Orthoreovirus, Avian / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology; D012088:Reoviridae Infections / Q000662:veterinary / Q000821:virology; D014118:Toxins, Biological; D014422:Turkeys / Q000821:virology; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D004768:Enterotoxins; D006023:Glycoproteins; C081369:NS28 protein, rotavirus; D011993:Recombinant Fusion Proteins; D014118:Toxins, Biological; D017361:Viral Nonstructural Proteins