title: Sonographic morphology of infiltrating breast carcinoma: relationship with the shape of the hyaluronan extracellular matrix.
abstract: OBJECTIVE
  To compare the shape of the sonographic image of invasive breast cancer with the shape of the corresponding histopathologic section stained for components of the extracellular matrix, hyaluronan, and collagen.
  
  
  METHODS
  We studied 22 cases of breast carcinoma. Among them, 13 were visible on both sonography and mammography, whereas 9 were visible only on sonography. We compared the sonographic images with the histologic sections of the same carcinomas after staining with alcian blue for hyaluronan and Masson trichrome for collagen.
  
  
  RESULTS
  We have shown that the shape of the sonographic image of breast cancer is similar to the shape of its hyaluronan extracellular matrix.
  
  
  CONCLUSIONS
  This finding explains why breast sonography is so sensitive for detection of invasive carcinoma and why some invasive cancers are not visible on mammography.
authors: Unité de Sénologie, Centre Hospitalier Universitaire Henri Mondor, Créteil, France.
authors: Philippe
authors: P
authors: Vignal
authors: Marie Reine
authors: MR
authors: Meslet
authors: Jean Michel
authors: JM
authors: Roméo
authors: Franck
authors: F
authors: Feuilhade
mesh_terms: D000423:Alcian Blue; D001943:Breast Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000473:pathology; D004396:Coloring Agents; D005109:Extracellular Matrix / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis*; D008875:Middle Aged; D016217:Ultrasonography, Mammary
chemical_list: D004396:Coloring Agents; D006820:Hyaluronic Acid; D000423:Alcian Blue