title: Effects of modified ultrafiltration on coagulation factors in pediatric cardiac surgery.
abstract: OBJECTIVE
  Modified ultrafiltration (MUF) after cardiopulmonary bypass (CPB) in children has been reported to reduce the need for postoperative blood transfusion and minimize postoperative blood loss. This study was undertaken to quantify the effects of MUF on coagulation factors in pediatric patients.
  
  
  METHODS
  Seven children scheduled to undergo open-heart surgery for congenital heart defects were studied. CPB circuits were primed with crystalloid solutions and no blood transfusions were performed. Hematocrit, platelet count, total plasma proteins, albumin, fibrinogen, prothrombin, factor VII, factor IX, and factor X were measured preoperatively, at the termination of cardiopulmonary bypass, and at the end of modified ultrafiltration.
  
  
  RESULTS
  MUF was associated with significant (P < 0.05) increases in hematocrit (17.6% +/- 1.6% to 21.6% +/- 2.4%), platelet count 11.1 +/- 2.5 to 12.8 +/- 2.4 x 10(4)/mm3), total plasma proteins (2.7 +/- 0.3 to 3.4 +/- 0.4 g/dl), and albumin (1.6 +/- 0.2 to 2.1 +/- 0.2 g/dl). Fibrinogen, prothrombin, and factor VII also increased significantly (P < 0.05) during MUF, but factor IX and factor X did not change.
  
  
  CONCLUSIONS
  We conclude that MUF attenuates the dilutional coagulopathy that occurs during CPB in children. There were slight improvements in the coagulation factors when MUF was employed.
authors: Department of Cardiothoracic Surgery, Kobe Children's Hospital, Hyogo, Japan.
authors: Yoshio
authors: Y
authors: Ootaki
authors: Masahiro
authors: M
authors: Yamaguchi
authors: Yoshihiro
authors: Y
authors: Oshima
authors: Naoki
authors: N
authors: Yoshimura
authors: Shigeteru
authors: S
authors: Oka
mesh_terms: D001779:Blood Coagulation Factors / Q000032:analysis*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D006330:Heart Defects, Congenital / Q000601:surgery; D006400:Hematocrit; D006440:Hemofiltration / Q000379:methods*; D006801:Humans
chemical_list: D001779:Blood Coagulation Factors