Design, synthesis and biological evaluation of a new bridged immunosuppressor.
A bridged peptide with the sequence: H-Thr-Pro-Gln-Arg-Gly-Asp-Val-gamma-Abu-Asn-Asp-Gln-Glu-Glu-Thr-Thr-Gly-Val-Val-Ser-Thr-Pro-Leu-Ile-Arg-Asn-Gly-OH was designed to mimic the discontinuous epitope of the HLA-DQ molecule that might interact with CD4. The bridged peptide revealed distinct suppressory effect in the humoral immune response. This result supports our suggestion that the 164-172 region of the HLA-DQ molecule may enhance its interactions with coreceptors, possibly with CD4.
Szewczuk
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Z
Faculty of Chemistry, University of Wrocław, Poland. szewczuk@wchuwr.chem.uni.wroc.pl
Wilczyński
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A
Petry
I
I
Siemion
I Z
IZ
Wieczorek
Z
Z
D000818:Animals; D001665:Binding Sites; D015704:CD4 Antigens / Q000096:biosynthesis / Q000737:chemistry; D000939:Epitopes; D006683:HLA-DQ Antigens / Q000737:chemistry; D006801:Humans; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D008958:Models, Molecular; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D017434:Protein Structure, Tertiary; D013997:Time Factors
D015704:CD4 Antigens; D000939:Epitopes; D006683:HLA-DQ Antigens; D007166:Immunosuppressive Agents; D010455:Peptides