title: Tracking T cells with tetramers: new tales from new tools.
abstract: To understand the success or failure of immune responses against pathogens or tumours requires the direct measurement of specific lymphocytes. Recently, there has been an explosion of data in this field through the use of several new tools for measuring the number and function of T cells. This has allowed immunologists who study human disease and mouse models of infection and cancer to readily track specific T cells--in both time and space. Although there are common patterns, over time, each host-pathogen relationship seems to develop unique characteristics, as reflected in the quality of the T-cell response.
authors: Nuffield Department of Medicine, University of Oxford, UK. klener@molbiol.ox.ac.uk
authors: Paul
authors: P
authors: Klenerman
authors: Vincenzo
authors: V
authors: Cerundolo
authors: P Rod
authors: PR
authors: Dunbar
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007202:Indicators and Reagents; D018655:Lymphocyte Count; D046911:Macromolecular Substances; D009369:Neoplasms / Q000276:immunology*; D010455:Peptides / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D019809:Streptavidin; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I; D007202:Indicators and Reagents; D046911:Macromolecular Substances; D010455:Peptides; D011948:Receptors, Antigen, T-Cell; D001613:beta 2-Microglobulin; D019809:Streptavidin