title: [Susceptibility to Mycobacterium leprae of congenic hypertensive nude rat (SHR/NCrj-rnu) and production of cytokine from the resident peritoneal macrophages].
abstract: We have established a congenic hypertensive nude rat strain, SHR/NCrj-rnu, carrying nude (rnu) and hypertension genes which was produced using females of the SHR/NCrj rat and males of the F344/NJcl nude rat by cross-intercross system for 12 generations. We demonstrated the susceptibility to M. leprae infection of SHR/NCrj-rnu rats as compared with F344/NJcl-rnu rats. SHR/NCrj-rnu rats were highly susceptible to M. leprae, and the SHR/NCrj-rnu rats of both sexes showed massive swelling of legs due to multiplication of M. leprae. However, F344/NJcl-rnu rats of both sexes revealed very poor susceptibility to M. leprae. There was a wide difference in the susceptibility to M. leprae between the SHR/NCrj-rnu and the F344/NJcl-rnu rats. We also examined the cytokine production. The resident peritoneal macrophages of SHR/NCrj-rnu rats produced IL-1 alpha, IL-6, IL-10 and TNF alpha, whereas those of F344/NJcl-rnu rats produced only TNF alpha.
authors: Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aobacho, Higasimurayama-shi, Tokyo 189-0002, Japan.
authors: Yasuko
authors: Y
authors: Yogi
authors: Masumi
authors: M
authors: Endoh
authors: Tomoko
authors: T
authors: Banba
authors: Masanori
authors: M
authors: Kobayashi
authors: Hideki
authors: H
authors: Katoh
authors: Koichi
authors: K
authors: Suzuki
authors: Hiroko
authors: H
authors: Nomaguchi
mesh_terms: D000818:Animals; D016207:Cytokines / Q000096:biosynthesis*; D004198:Disease Susceptibility; D005260:Female; D007918:Leprosy / Q000276:immunology* / Q000473:pathology; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D008297:Male; D009166:Mycobacterium leprae / Q000276:immunology*; D051381:Rats; D011916:Rats, Inbred F344 / Q000235:genetics; D011918:Rats, Inbred SHR / Q000235:genetics; D011923:Rats, Nude / Q000235:genetics
chemical_list: D016207:Cytokines