title: Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.
abstract: Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here, we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster has controlled a highly pathogenic immunodeficiency virus challenge in a Rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These highly promising findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the AIDS epidemic.
authors: Vaccine Research Center, Yerkes Regional Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA.
authors: Rama Rao
authors: RR
authors: Amara
authors: Francois
authors: F
authors: Villinger
authors: John D
authors: JD
authors: Altman
authors: Shari L
authors: SL
authors: Lydy
authors: Shawn P
authors: SP
authors: O'Neil
authors: Silvija I
authors: SI
authors: Staprans
authors: David C
authors: DC
authors: Montefiori
authors: Yan
authors: Y
authors: Xu
authors: James G
authors: JG
authors: Herndon
authors: Linda S
authors: LS
authors: Wyatt
authors: Maria Angelito
authors: MA
authors: Candido
authors: Natalia L
authors: NL
authors: Kozyr
authors: Patricia L
authors: PL
authors: Earl
authors: James M
authors: JM
authors: Smith
authors: Hak-Ling
authors: HL
authors: Ma
authors: Bennett D
authors: BD
authors: Grimm
authors: Michael L
authors: ML
authors: Hulsey
authors: Harold M
authors: HM
authors: McClure
authors: Janet M
authors: JM
authors: McNicholl
authors: Bernard
authors: B
authors: Moss
authors: Harriet L
authors: HL
authors: Robinson
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D000818:Animals; D018791:CD4 Lymphocyte Count; D004353:Drug Evaluation, Preclinical; D007111:Immunity, Cellular; D018928:Immunity, Mucosal; D007115:Immunization Schedule; D007117:Immunization, Secondary; D007156:Immunologic Memory; D007413:Intestinal Mucosa / Q000276:immunology* / Q000821:virology; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D012007:Rectum; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D014611:Vaccination; D019444:Vaccines, DNA / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology / Q000627:therapeutic use; D014616:Vaccinia virus / Q000276:immunology; D019562:Viral Load; D014774:Virulence
chemical_list: D016915:AIDS Vaccines; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic