In vitro antiplasmodial activity of extracts of Argentinian plants.
Fifteen extracts from nine selected Argentine medicinal plants were tested for their antiplasmodial activity in vitro by assessing their ability to inhibit the uptake of [3H]-hypoxanthine into the Plasmodium falciparum K1 pyrimethamine/chloroquine resistant strain. The methanol extract of Satureja parvifolia showed good antiplasmodial activity (IC(50) 3 microg/ml). Inhibition of the growth of P. falciparum was also observed with aqueous extracts of Buddleja globosa and S. parvifolia.
Debenedetti
S
S
IQUJMEFA (UBA-CONICET), Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 956, Buenos Aires, Argentina.
Muschietti
L
L
van Baren
C
C
Clavin
M
M
Broussalis
A
A
Martino
V
V
Houghton
P J
PJ
Warhurst
D
D
Steele
J
J
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D001118:Argentina; D004351:Drug Resistance; D020128:Inhibitory Concentration 50; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D010936:Plant Extracts