title: Percutaneous left atrial appendage transcatheter occlusion to prevent stroke in high-risk patients with atrial fibrillation: early clinical experience.
abstract: BACKGROUND
  Thromboembolism due to atrial fibrillation (AF) is a frequent cause of stroke. More than 90% of thrombi in AF form in the left atrial appendage (LAA). Obliteration of the appendage may prevent embolic complications.
  
  
  RESULTS
  We evaluated the feasibility and safety of implanting a novel device for percutaneous left atrial appendage transcatheter occlusion (PLAATO). LAA occlusion using the PLAATO system was attempted in 15 patients with chronic AF at high risk for stroke, who are poor candidates for long-term warfarin therapy. The implant consists of a self-expanding nitinol cage covered with a polymeric membrane (ePTFE). The LAA was successfully occluded in 15/15 patients (100%). Angiography and transesophageal echocardiography (TEE) during the procedure showed that the device was well-seated in all patients and that there was no evidence of perforation, device embolization, or interference with surrounding structures. In 1 patient, the first procedure was complicated by a hemopericardium, which occurred during LAA access. A second attempt 30 days later was successful with no untoward sequela. No other complications occurred. At 1-month follow-up, chest fluoroscopy and TEE revealed continued stable implant position with smooth atrial-facing surface and no evidence of thrombus.
  
  
  CONCLUSIONS
  Thus, transcatheter closure of the LAA is feasible in humans. This novel implant technology may be appropriate for patients with AF who are not suitable candidates for anticoagulation therapy. Further trials are needed to show the long-term safety and its efficacy in reducing stroke.
authors: Cardiovascular Center Bethanien, Frankfurt, Germany. horst.sievert@ dgn.de
authors: Horst
authors: H
authors: Sievert
authors: Michael D
authors: MD
authors: Lesh
authors: Thomas
authors: T
authors: Trepels
authors: Heyder
authors: H
authors: Omran
authors: Antonio
authors: A
authors: Bartorelli
authors: Paola
authors: P
authors: Della Bella
authors: Toshiko
authors: T
authors: Nakai
authors: Mark
authors: M
authors: Reisman
authors: Carlo
authors: C
authors: DiMario
authors: Peter
authors: P
authors: Block
authors: Paul
authors: P
authors: Kramer
authors: Dirk
authors: D
authors: Fleschenberg
authors: Ulrike
authors: U
authors: Krumsdorf
authors: Detlef
authors: D
authors: Scherer
mesh_terms: D000497:Alloys / Q000737:chemistry; D020517:Atrial Appendage; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000628:therapy*; D006328:Cardiac Catheterization / Q000379:methods; D017023:Coronary Angiography; D005240:Feasibility Studies; D006801:Humans; D011138:Polytetrafluoroethylene / Q000737:chemistry; D019736:Prostheses and Implants / Q000009:adverse effects; D012867:Skin; D020521:Stroke / Q000517:prevention & control*; D013923:Thromboembolism / Q000517:prevention & control*
chemical_list: D000497:Alloys; C013616:nitinol; D011138:Polytetrafluoroethylene