Reactive intermediates in peptide synthesis: the N-oxysuccinimido ester of Nalpha-para-toluenesulfonyl-alpha-aminoisobutyric acid.
The preparation, characterization, and molecular and crystal structures of succinimido 2-(tosylamino)isobutyrate, C(15)H(18)N(2)O(6)S, are described. The succinimido ring is nearly orthogonal to the ester group.
Crisma
Marco
M
Biopolymer Research Centre, CNR, Department of Organic Chemistry, University of Padova, Via Marzolo 1, 35131 Padova, Italy. marco.crisma@unipd.it
Toniolo
Claudio
C
D000621:Aminoisobutyric Acids / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D010455:Peptides / Q000138:chemical synthesis*; D013388:Succinimides / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
D000621:Aminoisobutyric Acids; C460383:N-oxysuccinimido N(alpha)-4-toluenesulfonyl-alpha-aminoisobutyrate; D010455:Peptides; D013388:Succinimides; D013449:Sulfonamides