Familial temporal lobe epilepsy with febrile seizures.
Described are the clinical, EEG, MR, and genetic characteristics of 106 members of a family with autosomal dominant temporal lobe epilepsy (TLE) and febrile seizures (FS), with 22 affected individuals. Eleven patients had a history of FS, and 10 patients had TLE. EEG showed epileptic activity in five. None had hippocampal sclerosis. There was no evidence for linkage to 13 candidate loci. This large family with autosomal dominant TLE has a distinct phenotype and shows no linkage to known candidate regions for familial partial epilepsy and FS.
Depondt
C
C
Department of Neurology, Centre for Human Genetics, University Hospital of Leuven, Belgium. c.depondt@ion.ucl.ac.uk
Van Paesschen
W
W
Matthijs
G
G
Legius
E
E
Martens
K
K
Demaerel
P
P
Wilms
G
G
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D001530:Belgium / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006801:Humans; D015994:Incidence; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D011379:Prognosis; D003294:Seizures, Febrile / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*