title: Translocation (1;19)(q21;q13.3) is a recurrent reciprocal translocation in meningioma.
abstract: Benign meningiomas are characterized by a normal karyotype or loss of all or part of chromosome 22. Histologically higher grade tumors are typically characterized by a pattern of increasing chromosome loss and instability. This characteristic pattern of unbalanced chromosome aberrations is punctuated in the literature by several intriguing reports of a reciprocal t(1;19)(q21;q13.3) as the sole cytogenetic aberration. We report a third case showing the t(1;19)(q21;q13.3) with additional unstable secondary aberrations of a dic(18;22)(p11;p11) and telomeric fusions.
authors: Department of Pathology, University of Arkansas for Medical Sciences, 4301 W. Markham, Little Rock, AR 72205, USA. sawyerjr@uams.edu
authors: Jeffrey R
authors: JR
authors: Sawyer
authors: Edward L
authors: EL
authors: Thomas
authors: Ossama
authors: O
authors: Al-Mefty
mesh_terms: D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008579:Meningioma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D014178:Translocation, Genetic