Diabetes and the risk of prostate cancer.
The relation between diabetes and prostate cancer risk was investigated in a combined analysis of two hospital-based case-control studies conducted in Italy and Greece, between 1985 and 1997. Cases were 608 men with incident prostate cancer, and controls were 1008 men admitted to hospital for acute non-neoplastic diseases. No material association between diabetes and prostate cancer was observed, with a multivariate odds ratio (OR) of 1.07 (95% confidence interval (CI) 0.68-1.66). Compared with men without diabetes, there was a non-significant increased risk of prostate cancer in those diagnosed with diabetes within the last 5 years (OR 2.04), while the ORs were 0.96 and 0.78 respectively for a diagnosis of diabetes 5-9 years and > or = 10 years ago.
Tavani
A
A
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy. tavani@marionegri.it
Gallus
S
S
Bosetti
C
C
Tzonou
A
A
Lagiou
P
P
Negri
E
E
Trichopoulos
D
D
La Vecchia
C
C
D000368:Aged; D016022:Case-Control Studies; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology*; D006115:Greece / Q000453:epidemiology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000453:epidemiology*; D012306:Risk; D013997:Time Factors