title: [Proteases of neutrophilic granulocytes].
abstract: The literature referring to proteolytic enzymes of neutrophilic granulocytes was surveyed. Biosynthesis, subcellular distribution, division according to the catalytic site structure, inhibitors and methods used to determine the activity of these enzymes were discussed. The survey included metaloproteases (granulocytic collagenase, gelatinase B), serine proteases (granulocytic elastase, cathepsin G, protease 3), membraneous proteases (aminopeptidase N, aminopeptidase P, neprilisine), cysteine and aspartic cathepsins. The role of these proteases in the pathology and diagnostics of certain diseases was considered.
authors: Zakład Analizy Instrumentalnej, Akademii Medycznej w Białymstoku.
authors: Wiesława
authors: W
authors: Roszkowska-Jakimiec
authors: Anna
authors: A
authors: Worowska
authors: Marek
authors: M
authors: Gacko
authors: Tomasz
authors: T
authors: Maksimowicz
mesh_terms: D002403:Cathepsins / Q000378:metabolism; D010450:Endopeptidases / Q000187:drug effects / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000201:enzymology*; D012697:Serine Endopeptidases / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D002403:Cathepsins; D010450:Endopeptidases; D012697:Serine Endopeptidases; D014568:Urokinase-Type Plasminogen Activator