Sulfated ferulic acid is the main in vivo metabolite found after short-term ingestion of free ferulic acid in rats.
The bioavailability of ferulic acid (FA; 3-methoxy-4-hydroxycinnamic acid) and its metabolites was investigated in rat plasma and urine after an oral short-term ingestion of 5.15 mg/kg of FA. Free FA, glucuronoconjugates, and sulfoconjugates were quickly detected in plasma with a peak of concentration found 30 min after ingestion. Sulfoconjugates were the main derivates ( approximately 50%). In urine, the cumulative excretion of total metabolites reached a plateau 1.5 h after ingestion, and approximately 40% were excreted by this way. Free FA recovered in urine represented only 4.9 +/-1.5% of the native FA consumed by rats. Glucuronoconjugates and sulfoconjugates represented 0.5 +/- 0.3 and 32.7 +/- 7.3%, respectively. These results suggested that a part of FA incorporated in the diet was quickly absorbed and largely metabolized in sulfoconjugates before excretion in urine.
Rondini
Ludovic
L
ENSIA, Département Science de l'Aliment, Laboratoire de Chimie des Substances Naturelles: Antioxydants, Arômes, Colorants, 1 Avenue des Olympiades, 91744 Massy Cedex, France.
Peyrat-Maillard
Marie-Noëlle
MN
Marsset-Baglieri
Agnès
A
Berset
Claudette
C
D000818:Animals; D001682:Biological Availability; D003373:Coumaric Acids / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D020719:Glucuronides / Q000378:metabolism; D007700:Kinetics; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013431:Sulfates / Q000378:metabolism*
D003373:Coumaric Acids; D020719:Glucuronides; D013431:Sulfates; C004999:ferulic acid