title: Chromosome changes in sarcomatoid renal carcinomas are different from those in renal cell carcinomas.
abstract: Sarcomatoid renal carcinoma (SRC) is an uncommon and highly malignant renal tumor with sarcomatous morphology or with both sarcomatous and carcinomatous components. The tumors are generally referred to as dedifferentiated or transformed renal cell carcinomas (RCC). Information on their genomic changes is scarce. Data from a cytogenetic study of four cases of SRC are presented in this article. Combined with a few other cases from the literature, it appears that genomic changes in most cases of SRC have little in common with those characterizing conventional RCC. Sarcomatoid transformation thus may occur occasionally in RCC without the characteristic chromosome changes but also, and perhaps more frequently, in a subgroup of RCC without the characteristic chromosome changes.
authors: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Brookline Avenue, Boston, MA, USA. pdalcin@partners.org
authors: Paola
authors: P
authors: Dal Cin
authors: Raf
authors: R
authors: Sciot
authors: Hein
authors: H
authors: Van Poppel
authors: Piera
authors: P
authors: Balzarini
authors: Tania
authors: T
authors: Roskams
authors: Herman
authors: H
authors: Van den Berghe
mesh_terms: D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D012509:Sarcoma / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic