title: Antiplasmodial activity of naphthoquinones and one anthraquinone from Stereospermum kunthianum.
abstract: A lipophilic extract of the root bark of Stereospermum kunthianum revealed antiplasmodial activity in vitro. Bioassay-guided fractionation led to the isolation of four novel naphthoquinones (sterekunthals A and B, pyranokunthones A and B) and one novel anthraquinone (anthrakunthone) together with the known naphthoquinone pinnatal. The structures of the novel compounds were determined by comprehensive analyses of their 1D and 2D NMR data. The antiplasmodial activities and toxicity against the endothelial cell line ECV-304 of the isolated compounds have been assessed.
authors: Department of Pharmacy (Pharmacognosy Unit), Makerere University, Kampala, Uganda.
authors: Bernardina
authors: B
authors: Onegi
authors: Carola
authors: C
authors: Kraft
authors: Inga
authors: I
authors: Köhler
authors: Marion
authors: M
authors: Freund
authors: Kristina
authors: K
authors: Jenett-Siems
authors: Karsten
authors: K
authors: Siems
authors: Gabriele
authors: G
authors: Beyer
authors: Matthias F
authors: MF
authors: Melzig
authors: Ulrich
authors: U
authors: Bienzle
authors: Eckart
authors: E
authors: Eich
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D029402:Bignoniaceae / Q000737:chemistry*; D002460:Cell Line; D004727:Endothelium / Q000166:cytology / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008288:Malaria / Q000188:drug therapy; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D009285:Naphthoquinones