title: RTS1-an eukaryotic terminator of replication.
abstract: Eukaryotic replication termination generally occurs randomly in the region between two active origins. However, termination, or pausing of the replication forks has been observed at specific loci. Recently, a site-specific terminator of replication named RTS1 was shown to play an important role in mating-type switching in Schizosaccharomyces pombe. Mating-type switching in S. pombe relies on an imprinting event that chemically modifies one strand of the DNA at the mating-type locus mat1. This imprint, that is formed only when mat1 is replicated in a specific direction, marks the DNA for a rearrangement leading to mating-type switching. The RTS1 element ensures that mat1 is replicated in the correct direction for imprinting and initiation of the subsequent mating-type switching event. This is the first replication terminator shown to play a role in cellular differentiation.
authors: Marie Curie Research Institute, The Chart, Oxted, Surrey RH80TL, UK.
authors: Sonya
authors: S
authors: Vengrova
authors: Sandra
authors: S
authors: Codlin
authors: Jacob Z
authors: JZ
authors: Dalgaard
mesh_terms: D000818:Animals; D001483:Base Sequence; D004261:DNA Replication / Q000502:physiology*; D004271:DNA, Fungal / Q000235:genetics / Q000378:metabolism; D018392:Genomic Imprinting; D006801:Humans; D008969:Molecular Sequence Data; D012568:Schizosaccharomyces / Q000502:physiology*; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism*
chemical_list: D004271:DNA, Fungal; D029702:Schizosaccharomyces pombe Proteins