title: Biomaterial implants induce the inflammation marker CRP at the site of implantation.
abstract: Following implantation of biomaterial patches into the gastrointestinal tract, we analyzed the host's response towards the foreign material. Asymmetric patches of polydioxanone covered Vicryl or poly-3-hydroxybutyrate were sutured onto the rat stomach. Tissue samples were generated at distinct time intervals after surgery, and RNA profiles were compared by Differential Display. RT-PCR analysis of gene candidates that seemed differentially expressed showed that vitamin D binding protein mRNA was induced in stomach tissue after implantation of the biomaterial patches. In parallel, the amount of C-reactive protein mRNA was found to be increased transiently as well. Implants induce a tissue response that is specific for a given material.
authors: Chirurgische Universitätsklinik der Universität Freiburg, Hugstetter Strasse 55, Germany. loebler@chil.ukl.unifreiburg.de
authors: Marian
authors: M
authors: Löbler
authors: Marko
authors: M
authors: Sass
authors: Carmen
authors: C
authors: Kunze
authors: Klaus-Peter
authors: KP
authors: Schmitz
authors: Ulrich T
authors: UT
authors: Hopt
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism; D015415:Biomarkers; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism*; D005549:Foreign-Body Reaction; D012313:RNA / Q000378:metabolism; D051381:Rats; D013270:Stomach / Q000502:physiology / Q000601:surgery
chemical_list: D001672:Biocompatible Materials; D015415:Biomarkers; D012313:RNA; D002097:C-Reactive Protein