Regulation of ROMK channels by protein tyrosine kinase and tyrosine phosphatase.
Renal outer medulla K (ROMK) channels play an important role in K recycling in the thick ascending limb and in K secretion in the cortical collecting duct. ROMK1, a member of the ROMK family, has been shown to be a substrate for protein tyrosine kinase (PTK). The tyrosine phosphorylation of ROMK channels increases with low dietary K intake and decreases with high dietary K intake. Moreover, the stimulation of tyrosine phosphorylation of ROMK1 channels decreases the number of K channels by facilitating endocytosis. In contrast, the stimulation of tyrosine dephosphorylation increases the number of ROMK1 channels in the cell membrane by enhancing membrane insertion. PTK and tyrosine phosphatase-induced regulation of ROMK1 channels play a key role in mediating the effect of the dietary K intake on renal K secretion.
Wang
Wen-Hui
WH
Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA. wenhui_wang@nymc.edu
Lin
Dao-Hong
DH
Sterling
Hyacinth
H
D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D015221:Potassium Channels / Q000378:metabolism*; D024661:Potassium Channels, Inwardly Rectifying; D017419:Potassium, Dietary / Q000494:pharmacology*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*
C086989:KCNJ1 protein, human; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; D017419:Potassium, Dietary; D011505:Protein-Tyrosine Kinases; D017027:Protein Tyrosine Phosphatases; D011188:Potassium