Successful multimodality therapy of recurrent multifocal juvenile granulosa cell tumor of the ovary.
Juvenile granulosa cell tumor (JGCT) of the ovary, a rare pediatric cancer, carries a very poor prognosis in advanced and recurrent cases. A 10-year-old girl with stage IA JGCT, initially treated with resection only, presented with extensive unresectable multifocal pelvic recurrence. She underwent surgery, chemotherapy (cisplatin/paclitaxel alternating with cisplatin/cyclophosphamide/etoposide/bleomycin), myeloablative chemotherapy (carboplatin/etoposide/melphalan) with autologous bone marrow transplant, and pelvic radiation. She tolerated therapy well and is in complete remission 69 months after her recurrence.
Erdreich-Epstein
Anat
A
Department of Pediatrics, Childrens Hospital Los Angeles, Keck School of Medicine, California 90027, USA. epstein@hsc.usc.edu
Monforte
Hector L
HL
Lavey
Robert S
RS
Joshi
Sarita
S
Phillips
J Duncan
JD
Villablanca
Judith G
JG
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002648:Child; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D013502:General Surgery; D006106:Granulosa Cell Tumor / Q000473:pathology / Q000628:therapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome