Antiplasmodial activity of naphthoquinones and one anthraquinone from Stereospermum kunthianum.
A lipophilic extract of the root bark of Stereospermum kunthianum revealed antiplasmodial activity in vitro. Bioassay-guided fractionation led to the isolation of four novel naphthoquinones (sterekunthals A and B, pyranokunthones A and B) and one novel anthraquinone (anthrakunthone) together with the known naphthoquinone pinnatal. The structures of the novel compounds were determined by comprehensive analyses of their 1D and 2D NMR data. The antiplasmodial activities and toxicity against the endothelial cell line ECV-304 of the isolated compounds have been assessed.
Onegi
Bernardina
B
Department of Pharmacy (Pharmacognosy Unit), Makerere University, Kampala, Uganda.
Kraft
Carola
C
Köhler
Inga
I
Freund
Marion
M
Jenett-Siems
Kristina
K
Siems
Karsten
K
Beyer
Gabriele
G
Melzig
Matthias F
MF
Bienzle
Ulrich
U
Eich
Eckart
E
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D029402:Bignoniaceae / Q000737:chemistry*; D002460:Cell Line; D004727:Endothelium / Q000166:cytology / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008288:Malaria / Q000188:drug therapy; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*
D000981:Antiprotozoal Agents; D009285:Naphthoquinones