title: Locobase repair cream following CO2 laser skin resurfacing reduces interstitial fluid oozing.
abstract: BACKGROUND
  The cosmetic result after laser resurfacing depends not only on the type of laser and the technique used, but also on post-treatment care. The efficacy of Locobase Repair((R)) cream, which improves skin barrier function due to its content of natural skin analogue fats and cholesterol, was investigated.
  
  
  METHODS
  A total of 18 Caucasian patients underwent resurfacing for acne scars. Laser treatment was performed with a Sharplan 1020 CO(2) laser and a Silk Touch scanner. Locobase Repair cream (a water-in-oil cream with 63% lipids including natural components of stratum corneum: cholesterol, ceramide and free fatty acids) was applied daily to one side of the face and petrolatum was applied to the other. In addition, both sides were treated with a 2% fusidic acid cream.
  
  
  RESULTS
  There was a significant reduction of oozing during the first 2 days after CO(2) laser treatment on the sides treated with Locobase Repair cream (p < 0.05), CO(2) laser while from day 3 to day 7 no differences were demonstrated between the Locobase Repair cream and petrolatum. For the other parameters scored (scaling, oedema, erythema and pain), no significant differences between Locobase Repair cream and petrolatum were found. Furthermore, no significant differences were found between the two creams regarding the duration of wound healing and final cosmetic outcome. In all, 62% of the patients preferred to use Locobase Repair cream during the postoperative period, and 11% preferred petrolatum. The remaining 27% expressed no preferences.
  
  
  CONCLUSIONS
  The use of Locobase Repair cream as a post laser resurfacing treatment reduces tissue fluid oozing during the first 2 postoperative days, indicating a quick restoration of skin barrier and hence possibly a reduction in the incidence of wound infections as well as enhancing patient compliance due to less fluid oozing.
authors: Department of Dermatology D, University Hospital of Aarhus, Aarhus, Denmark. janne-touborg@dadlnet.dk
authors: J T
authors: JT
authors: Mortensen
authors: P
authors: P
authors: Bjerring
authors: M
authors: M
authors: Cramers
mesh_terms: D000152:Acne Vulgaris / Q000150:complications; D000328:Adult; D002245:Carbon Dioxide / Q000627:therapeutic use; D002921:Cicatrix / Q000209:etiology / Q000601:surgery*; D062109:Dermatologic Surgical Procedures; D004643:Emollients / Q000627:therapeutic use*; D005122:Exudates and Transudates; D005145:Face / Q000601:surgery*; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010577:Petrolatum / Q000627:therapeutic use; D011182:Postoperative Care / Q000379:methods*; D019651:Plastic Surgery Procedures / Q000379:methods; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D004643:Emollients; D002245:Carbon Dioxide; D010577:Petrolatum