Cell cycle: stressed out of mitosis.
Cells in early stages of chromosome condensation are very vulnerable, and many stresses that do not damage DNA induce a transient return to late G2 phase. Such stresses include the drug-induced disassembly of microtubules, which triggers an ATM-independent G2 checkpoint pathway involving a novel ubiquitin ligase.
Mikhailov
Alexei
A
Division of Molecular Medicine, Wadsworth Center, New York State Dept. of Health, Albany, NY 12201-0509, USA.
Rieder
Conly L
CL
D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism; D016195:G2 Phase / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism*; D008938:Mitosis / Q000187:drug effects / Q000502:physiology*; D009363:Neoplasm Proteins; D015739:Nocodazole / Q000494:pharmacology*; D000075223:Poly-ADP-Ribose Binding Proteins; D044767:Ubiquitin-Protein Ligases
D018797:Cell Cycle Proteins; D009363:Neoplasm Proteins; D000075223:Poly-ADP-Ribose Binding Proteins; C412002:CHFR protein, human; D044767:Ubiquitin-Protein Ligases; D015739:Nocodazole