title: Metastatic lymphangiosarcoma in a horse.
abstract: A lymphangiosarcoma with metastases was found in a horse that presented with respiratory distress and edema in the ventral thorax and abdomen. The necropsy revealed diffuse edema in the subcutaneous connective tissue. Mediastinal, mesenteric, iliac, and renal lymph nodes were enlarged and white with soft, yellowish necrotic areas. Histologic examination revealed numerous channels and disorganized vessels lined by large polyhedral, polymorphic cells. Tumor metastases were observed in the spleen, lungs, and kidneys. Immunohistochemical evaluation of the tumor cells demonstrated positive staining for factor VIII, vimentin, and keratin. Laminin was scarce, and collagen IV staining was negative, consistent with a discontinuous or absent basement membrane.
authors: Departamento de Patologia Animal II, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain.
authors: B
authors: B
authors: Sanchez
authors: A
authors: A
authors: Nieto
authors: M A
authors: MA
authors: de Ruiz Leon
authors: J
authors: J
authors: Rodríguez
authors: J
authors: J
authors: Flores
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000473:pathology; D005260:Female; D006734:Horse Diseases / Q000276:immunology / Q000473:pathology*; D006736:Horses; D007150:Immunohistochemistry; D008204:Lymphangiosarcoma / Q000276:immunology / Q000473:pathology / Q000556:secondary / Q000662:veterinary*; D008207:Lymphatic Metastasis; D008208:Lymphatic System / Q000473:pathology; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D014841:von Willebrand Factor