[Liver monooxygenase system inducers in the treatment of respiratory distress syndrome in newborn].
Physical and biochemical parameters of pulmonary surfactant (PS) were studied in 6-day-old rabbits with the respiratory distress syndrome (RDS) treated by benzonal and zixorin inductors. Surface-active characteristics of PS were impaired under conditions of RDS at the expense of deficiency of total phospholipids, specifically phosphatidylcholine (PC) and phosphatidylethanolamine (PEA). Treatment with benzonal and zixorin improved the surface-active characteristics of PS and increased the content of total phospholipids mainly at the expense of PC and PEA.
Kabulov
Sh M
ShM
D000818:Animals; D000831:Animals, Newborn; D001463:Barbiturates / Q000627:therapeutic use*; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004790:Enzyme Induction; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D010105:Oxygenases / Q000096:biosynthesis*; D010743:Phospholipids / Q000032:analysis; D011663:Pulmonary Surfactants / Q000737:chemistry; D011817:Rabbits; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy*; D013499:Surface Properties
D001463:Barbiturates; D001559:Benzhydryl Compounds; D010743:Phospholipids; D011663:Pulmonary Surfactants; D010105:Oxygenases; C016914:flumecinol; C002915:benzobarbital