title: Acute disseminated encephalomyelitis in adults: a reappraisal of clinical, CSF, EEG, and MRI findings.
abstract: OBJECTIVE
  To establish an adequate definition of acute disseminated encephalomyelitis (ADEM) in adults, based on our clinical observations of a case-series.
  
  
  METHODS
  Over a period of three years 10 adult patients with a para- or postinfectious disseminated (diffuse or multifocal) syndrome of the CNS fulfilling predefined strict criteria for the diagnosis of ADEM were encountered and systematically followed.
  
  
  RESULTS
  The age ranged from 21 to 62 years, two were men. MRI was normal in 5 patients and only mildly abnormal in the remaining patients. CSF was normal in 5 patients and mildly abnormal in the remainder, EEG was abnormal in 7/8 patients. All patients survived and were followed over a period of 30 months (range: 8 to 48 months). Nine patients were left with some residual defects, consisting most often of a mild cognitive impairment.
  
  
  CONCLUSIONS
  The EEG as an investigation of brain function can be crucial in establishing the organic nature of disease. MRI is important to exclude other diffuse or multifocal encephalopathies. However, in contrast to previous reports in the literature abnormal MRI should not be considered mandatory in adult ADEM. Difficulties in the diagnosis of ADEM are discussed and the importance of clinical and paraclinical findings for establishing the diagnosis is outlined.
authors: Department of Neurology, University of Bern, Switzerland.
authors: Peter
authors: P
authors: Höllinger
authors: Matthias
authors: M
authors: Sturzenegger
authors: Johannes
authors: J
authors: Mathis
authors: Gerhard
authors: G
authors: Schroth
authors: Christian W
authors: CW
authors: Hess
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002494:Central Nervous System Infections / Q000097:blood / Q000150:complications / Q000175:diagnosis; D004569:Electroencephalography; D004576:Electromyography; D004673:Encephalomyelitis, Acute Disseminated / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications; D006801:Humans; D007251:Influenza, Human / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D011247:Pregnancy; D012141:Respiratory Tract Infections / Q000150:complications; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone