title: Sensitization as a mechanism for multiple chemical sensitivity: relationship to evolutionary theory.
abstract: Multiple chemical sensitivity (MCS) is a disorder in humans attributed to prior chemical exposure. Sensitization is an amplification of neuronal responsiveness that elicits increased behavioral responding to stimuli, and occurs in a recently developed rat model of MCS. Rats were exposed to repeated formaldehyde (Form) and their response in three behavioral tests, including locomotor activity after a cocaine challenge, conditioned fear, and behavioral avoidance of Form, was assessed. In all three tests, rats demonstrated sensitized behaviors, implicating amplified responding within specific limbic brain regions. Evolutionary theory in the context of MCS specifies how the behavioral strategies of those with MCS are consistent with the notion that their self-perceived sense of survival and reproductive fitness may be threatened by chemical exposures. This behavior may be mediated by the same limbic brain regions that become sensitized after repeated chemical exposure in animals.
authors: Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164-6520, USA. barbsorg@vetmed.wsu.edu
authors: Barbara A
authors: BA
authors: Sorg
authors: David B
authors: DB
authors: Newlin
mesh_terms: D000818:Animals; D005075:Biological Evolution; D018777:Multiple Chemical Sensitivity / Q000209:etiology*; D051381:Rats; D020886:Somatosensory Disorders / Q000150:complications*