Bone marrow chimeras reveal non-H-2 hematopoietic control of susceptibility to Theiler's virus persistent infection.
The DA strain of Theiler's murine encephalomyelitis virus persists in the white matter of the spinal cords of susceptible mice. Previous results showed that the difference in susceptibility to viral persistence between the susceptible SJL/J strain and the resistant B10.S strain was due to multiple non-H-2 loci. The respective roles of hematopoietic and nonhematopoietic cells in this difference have been evaluated with bone marrow chimeras. The results show that non-H-2 loci with a major effect on susceptibility are expressed in hematopoietic cells. However, the study of the SJL.B10-D10Mit180-D10Mit74 congenic line suggests that other loci expressed in nonhematopoietic cells also play a role.
Aubagnac
Stéphanie
S
Unité des Virus Lents, CNRS URA 1930, Institut Pasteur, 75724 Paris Cedex 15, France.
Brahic
Michel
M
Bureau
Jean-François
JF
D000818:Animals; D001854:Bone Marrow Cells / Q000276:immunology*; D016026:Bone Marrow Transplantation; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D005838:Genotype; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology*; D006410:Hematopoiesis / Q000235:genetics / Q000276:immunology; D064532:Histocompatibility Antigen H-2D; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000276:immunology*; D051379:Mice; D011051:Poliomyelitis / Q000235:genetics / Q000276:immunology* / Q000821:virology; D012367:RNA, Viral; D017945:Theilovirus / Q000276:immunology*; D018183:Transplantation Chimera / Q000276:immunology*; D019562:Viral Load; D017735:Virus Latency
D006183:H-2 Antigens; D064532:Histocompatibility Antigen H-2D; D012367:RNA, Viral