title: Intracranial aneurysms and dolichoectasia in autosomal dominant polycystic kidney disease.
abstract: BACKGROUND
  Intracranial saccular aneurysms (ICA) are a known extrarenal manifestation of autosomal dominant polycystic kidney disease (ADPKD). In order to facilitate the definition of subgroups who are at risk for ICA and to determine the prevalence of ICA in these subgroups we studied ADPKD patients with a positive family history for a cerebral event, including cerebral stroke (group I) and intracranial bleeding or known ICA (group II).
  
  
  METHODS
  Within an enrolment period of 21 months, 43 ADPKD patients from our outpatient clinic and hospital were examined with cerebral magnetic resonance angiography (MRA).
  
  
  RESULTS
  ICA were detected in six patients (14%). Three out of 32 patients (9.4%) in group I and three out of 11 patients (27.3%) in group II had an ICA. A dolichoectasia of intracerebral vessels was found in two out of 43 patients (4.7%).
  
  
  CONCLUSIONS
  Using MRA a high prevalence of ICA was shown only in patients with a family history of cerebral bleeding or ICA. A family history for cerebral stroke does not imply an elevated risk for ICA. However, dolichoectasia, rare in the normal population, was detected in two patients. We recommend screening for ICA in patients with a positive family history for cerebral bleeding or ICA. Because of potential complications, examiners should direct their attention to dolichoectasia in ADPKD patients.
authors: Department of Nephrology, University of Erlangen-Nürnberg, Germany.
authors: Stefan
authors: S
authors: Graf
authors: Alexander
authors: A
authors: Schischma
authors: Knut E
authors: KE
authors: Eberhardt
authors: Roland
authors: R
authors: Istel
authors: Birgit
authors: B
authors: Stiasny
authors: Bernd D
authors: BD
authors: Schulze
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications*; D015995:Prevalence; D014715:Vertebrobasilar Insufficiency / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*