title: Necrotic cutaneous lesions induced by hypereosinophilic syndrome secondary to a T-cell lymphoma.
abstract: Cutaneous lesions of hypereosinophilic syndrome (HES) may display various presentations. These are important to recognize to allow early diagnosis. We report an unusual case of a young man with HES secondary to a splenic T-cell lymphoma, revealed by diffuse necrotic cutaneous lesions. Later on, brain and heart infarctions developed, leading to the patient's death. Analysis of skin biopsy specimens showed occluded dermal vessels surrounded by activated eosinophils. Because a complete analysis of hemostasis was unremarkable, these findings suggest that dermal vessel thrombosis was the direct consequence of the migration of activated eosinophils. Cutaneous lesions of HES are protean and probably reflect the differences between the lesional events induced in situ by activated eosinophils.
authors: Unité de Dermatologie, Hôpital Tenon, Paris, France. selim.aractingi@tnn.ap-hop-paris.fr
authors: Sélim
authors: S
authors: Aractingi
authors: Claude
authors: C
authors: Bachmeyer
authors: Patricia
authors: P
authors: Pautier
authors: Michel
authors: M
authors: Barboteu
authors: Véronique
authors: V
authors: Meignin
authors: Marie Therese
authors: MT
authors: Daniel
authors: Jean Pierre
authors: JP
authors: Marolleau
authors: Anne
authors: A
authors: Janin
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D017809:Fatal Outcome; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000175:diagnosis; D007150:Immunohistochemistry; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000175:diagnosis; D008297:Male; D009336:Necrosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology*; D013160:Splenic Neoplasms / Q000150:complications* / Q000175:diagnosis