[Effect of bilirubin derivative on HIV-1 in vitro].
BACKGROUND
To study the effect of DTB against HIV-1, for developing anti-HIV drugs.


METHODS
Different concentration of DTB was added to cell culture system after viral inoculation, MTT staining method for viable cells (MTT assay) and p24 (ELISA) were used as markers to monitor the viral replication.


RESULTS
The inhibition rates of DTB at concentrations 160, 80, and 40mg/ml were 93.0%, 56.2% and 18.1%, respectively.


CONCLUSIONS
DTB could effectively inhibit HIV-1 in vitro.
Ye
Yao
Y
Institute of Virology, Chinese Academy Preventive Medicine, Beijing 100052, China.
Wang
Qi
Q
Chen
Guomin
G
Zhang
Yi
Y
Yan
Fang
F
Wang
Tianyu
T
Ma
Jinshi
J
Li
Zelin
Z
Zeng
Yi
Y
D019380:Anti-HIV Agents / Q000494:pharmacology*; D001663:Bilirubin / Q000031:analogs & derivatives / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques
D019380:Anti-HIV Agents; D001663:Bilirubin