[Hemosorption in serotherapy (serosorption) in experimental acute diphtheric toxemia with the use of affinity sorbents].
In modeling acute diphtheric toxemia in guinea pigs, the authors propose to perform hemosorption using selective sorbents under continuous introduction of antitoxic immune sera into extracorporeal contour in front of sorption column. Combination of hemosorption with serotherapy in the same time interval may be denoted as serosorption. As specific sorbents, affine preparations imasorb A-700 and Imasorb G-700 were used. They selectively eliminate from the blood flow CIC produced by diphtheric toxin (anatoxin) and antitoxic rabbit and horse antibodies. Changes in the titers of the diphtheric toxin (anatoxin) and CIC in blood evidence for efficiency of selective sorbents were confirmed by immunohistochemical analysis of the preparations' granules after hemoperfusion.
Kuznetsov
S I
SI
Barashkova
L N
LN
Burkova
N V
NV
Eĭsmont
Iu A
IuA
Korosteleva
Iu G
IuG
Kanaev
P A
PA
Nosikova
E V
EV
Ogurtsov
R P
RP
Tiukavin
A I
AI
D000818:Animals; D001426:Bacterial Proteins; D004165:Diphtheria / Q000276:immunology / Q000628:therapy*; D004168:Diphtheria Toxoid / Q000097:blood; D005260:Female; D006168:Guinea Pigs; D006464:Hemoperfusion / Q000379:methods*; D007106:Immune Sera; D008024:Ligands; D008297:Male; D011994:Recombinant Proteins; D012685:Sepharose / Q000031:analogs & derivatives*; D013211:Staphylococcus aureus; D013291:Streptococcus; D014115:Toxemia / Q000276:immunology / Q000628:therapy*; D013205:Staphylococcal Protein A
D001426:Bacterial Proteins; D004168:Diphtheria Toxoid; D007106:Immune Sera; D008024:Ligands; D011994:Recombinant Proteins; D012685:Sepharose; C042030:Staphylococcal protein A-sepharose; D013205:Staphylococcal Protein A