Multiple myeloma: evolving genetic events and host interactions.
Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which chromosome translocations frequently place oncogenes under the control of immunoglobulin enhancers. Unlike most haematopoietic cancers, multiple myeloma often has complex chromosomal abnormalities that are reminiscent of epithelial tumours. What causes full-blown myeloma? And can our molecular understanding of this common haematological malignancy be used to develop effective preventive and treatment strategies?
Kuehl
W Michael
WM
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda Naval Hospital, Maryland 20889-5105, USA. wmk@helix.nih.gov
Bergsagel
P Leif
PL
D001402:B-Lymphocytes / Q000502:physiology; D004742:Enhancer Elements, Genetic; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology; D009367:Neoplasm Staging; D009857:Oncogenes; D014178:Translocation, Genetic
D007136:Immunoglobulins