Syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by amiodarone: a report on two cases.
BACKGROUND
Amiodarone is an effective antiarrhythmic agent for life-threatening arrhythmias but has some noncardiac toxicity. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by amiodarone during long-term therapy seems to be rare among adverse effects.


RESULTS
We report on two elderly cases that developed hyponatremia caused by SIADH occurring during the initial loading period of amiodarone therapy. Both cases improved within 3 weeks after reduction of the dose, although amiodarone was continued.


CONCLUSIONS
Amiodarone-induced SIADH may occur during the initial loading period, and it may be improved by reduction of the dose without discontinuation of the drug.
Ikegami
Haruhiko
H
Department of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan.
Shiga
Tsuyoshi
T
Tsushima
Toshio
T
Nirei
Takashi
T
Kasanuki
Hiroshi
H
D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007010:Hyponatremia / Q000209:etiology; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000150:complications; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone