Acute disseminated encephalomyelitis after para-influenza infection post bone marrow transplantation.
Acute disseminated encephalomyelitis (ADEM) is a parainfectious or postvaccination demyelinating condition, characterized by rapid onset of multifocal neurological deficits, usually occurring in childhood or adolescence. We report case of ADEM in an allogeneic bone marrow transplant recipient, who presented with rapid onset of paraplegia and widespread neurological deficits 6 weeks after parainfluenza pneumonia. Magnetic resonance imaging (MRI) showed typical features of ADEM, involving the subcortical white matter, brain steam and spinal cord. There was a rapid and complete response to pulse high-dose corticosteriod and intravenous immunoglobulin. The importance of recognition and early treatment of this rare condition in transplantation practice is emphasized.
Au
Wing Y
WY
University Department of Medicine, Queen Mary Hospital, Hong Kong, People's Republic of China. auwing@hotmail.com
Lie
Albert K W
AK
Cheung
Raymond T F
RT
Cheng
P W
PW
Ooi
Clara G C
CG
Yujenc
Kwok-Yung
KY
Kwong
Yok-Lam
YL
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis / Q000209:etiology / Q000821:virology*; D006086:Graft vs Host Disease / Q000821:virology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009894:Opportunistic Infections / Q000209:etiology / Q000821:virology; D010224:Parainfluenza Virus 3, Human; D010253:Respirovirus Infections / Q000209:etiology*; D014184:Transplantation, Homologous / Q000009:adverse effects