title: Successful treatment of patients with von Willebrand disease using a high-purity double-virus inactivated factor VIII/von Willebrand factor concentrate (Immunate).
abstract: Fourteen patients with different types of von Willebrand disease (vWD) having acute bleeds or elective surgery were treated with Immunate(sound recording copyright sign), a double-virus inactivated factor VIII/von Willebrand factor (FVIII/vWF) concentrate. The concentrate was applied as a bolus or via continuous infusion. FVIII activity (FVIIIc), vWF antigen (vWF:Ag), ristocetin cofactor activity (vWF:RCo), collagen binding activity (vWF:CB), activated partial thromboplastin time (aPTT), and von Willebrand multimers (vW-multimers) were monitored for 48 hours. Pharmacokinetic analyses were performed. The clinical efficacy was rated excellent or good. Bleeding complications occurred in 3 patients due to an additional FXIII deficiency in one patient, to a surgically induced bleed in another patient, and a rather short substitution period in the third patient. There were no serious adverse experiences. One patient showed a phlebitic reaction at the site of venous access after more than 100 hours of continuous infusion, requiring a change to application via bolus.
authors: Prof. Hess Kinderklinik, St.-Jürgen-Strasse 1, Bremen, Germany.
authors: Günter
authors: G
authors: Auerswald
authors: Bruno
authors: B
authors: Eberspächer
authors: Werner
authors: W
authors: Engl
authors: Christiane
authors: C
authors: Güthner
authors: Marie
authors: M
authors: Koksch
authors: Wolfhart
authors: W
authors: Kreuz
authors: Antje
authors: A
authors: Nimtz
authors: Gerhard
authors: G
authors: Pindur
authors: Horst
authors: H
authors: Scheel
authors: Jörg D
authors: JD
authors: Schreiber
authors: Jürgen
authors: J
authors: Siekmann
authors: Peter L
authors: PL
authors: Turecek
authors: Hans-Heinrich
authors: HH
authors: Wolf
mesh_terms: D019411:Clinical Laboratory Techniques; D019281:Dimerization; D004338:Drug Combinations; D016903:Drug Monitoring / Q000379:methods; D005169:Factor VIII / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D019990:Perioperative Care / Q000379:methods; D013242:Sterilization; D016896:Treatment Outcome; D014842:von Willebrand Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D014841:von Willebrand Factor / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D004338:Drug Combinations; D014841:von Willebrand Factor; D005169:Factor VIII