[Assessment of time-dependent effects of long-acting altiazem in patients with hypertension stage II].
A chronodiagnostic examination covered 27 patients with hypertension stage II of indifferent chronotype. The patients were divided into 3 groups by the time of intake of a single daily dose of altiazem--at 8 a.m., 14 p.m., 20 p.m. Chronological organization of the cardiovascular system was studied with autorhythmometry for 3 days in 4-h intervals including night before and in the end of the treatment. Echo-CG, doppler echocardiography and rheoencephalography investigated hemodynamics once daily also before and in the end of the treatment. The findings show advantage of chronotherapeutic prescription of altiazem PP in a mean dose 220 mg/day at evening hours in non-chronodependent patients with hypertension stage II because such a regimen brought about more adequate restoration of the cardiovascular system time organization both by the spectrum of significant rhythms and their parameters; by better improvement of left ventricular diastolic function and pulse cerebral flow. Faster achievement of the therapeutic effect in the evening intake of altiazem supports its chronotherapeutic administration. This leads to reduction of the drug course dose and, therefore, treatment duration.
Beliaev
S D
SD
Khetagurova
L G
LG
Zaslavskaia
R M
RM
D000328:Adult; D000368:Aged; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D019454:Chronotherapy; D003692:Delayed-Action Preparations; D004110:Diltiazem / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013997:Time Factors
D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D004110:Diltiazem