Gene expression: the close coupling of transcription and splicing.
Increasing evidence indicates that the transcriptional machinery can influence the efficiency of splicing as well as splice-site selection. Surprisingly, it has now been demonstrated that splicing components influence the efficiency of transcription. This mutual stimulation has important implications for the regulation of gene expression.
Rosonina
Emanuel
E
Banting and Best Department of Medical Research, Department of Molecular and Medical Genetics, Charles H. Best Institute, University of Toronto, 112 College St., Toronto, Ontario M5G 1L6, Canada.
Blencowe
Benjamin J
BJ
D005786:Gene Expression Regulation; D012319:RNA Polymerase II / Q000378:metabolism; D012326:RNA Splicing; D014158:Transcription, Genetic
D012319:RNA Polymerase II