[Genetics en epileptology].
Recently, major advances have been obtained concerning the molecular genetic basis of Mendelian inherited epilepsies. Several responsible genes have been identified, leading to a better understanding of the pathophysiology of epilepsy, as well as new approaches in its diagnosis and treatment. However, several questions remain. Indeed, Mendelian epilepsies are rare and few patients are concerned. Despite several lines of evidence demonstrating the involvement of genetic factors in the common forms of epilepsy, no progress has been made in this field. Statistical and molecular strategies adapted to identify susceptibility genes for common epilepsies are now available. But these approaches require large samples of patients and relatives, and a collaborative network will be required for characterisation.
Malafosse
A
A
Division de neuropsychiatrie, Hôpitaux Universitaires de Genève, Switzerland. malafoss@cmu.unige.ch
D004569:Electroencephalography; D004827:Epilepsy / Q000145:classification / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans