title: A novel general route for the synthesis of C-glycosyl tyrosine analogues.
abstract: A general method for the synthesis of C-glycosyl amino acids is described here. The stereoisomerically pure tyrosine analogues alpha-L-4 and beta-L-6 are prepared in reasonable overall yields from allyl derivatives 10 and 11. The key step is a benzannulation procedure which is employed in the creation of the aromatic ring that bears the amino acid function.
authors: Dipartmento di Chimica del Politecnico, Centro CNR per lo Studio del Sostanze Organiche Naturali, Milano, Italy. brenna@dept.chem.polimi.it
authors: Elisabetta
authors: E
authors: Brenna
authors: Claudio
authors: C
authors: Fuganti
authors: Piero
authors: P
authors: Grasselli
authors: Stefano
authors: S
authors: Serra
authors: Sabrina
authors: S
authors: Zamboti
mesh_terms: D003640:Dealkylation; D006027:Glycosides / Q000138:chemical synthesis; D006031:Glycosylation; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D006027:Glycosides; D007202:Indicators and Reagents; D014443:Tyrosine