Antifungal chemoprophylaxis after blood and marrow transplantation.
Invasive fungal infections are common and deadly in recipients of blood and marrow transplants. Current diagnostic techniques do not allow accurate early diagnosis, especially of infection with mould pathogens, and delays in diagnosis are associated with treatment failure. This lack of early diagnosis has provided the impetus for the development of antifungal prophylaxis. Fluconazole prophylaxis is highly effective for the control of invasive yeast infections and associated with few breakthrough infections. The development of antimould prophylaxis in this patient population is a high priority.
Wingard
John R
JR
Division of Hematology/Oncology, University of Florida College of Medicine, Gainesville, FL 32610, USA. wingajr@medicine.ufl.edu
D000935:Antifungal Agents / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000517:prevention & control*; D018890:Chemoprevention; D015725:Fluconazole / Q000627:therapeutic use*; D005544:Forecasting; D006801:Humans; D065227:Transfusion Reaction
D000935:Antifungal Agents; D015725:Fluconazole