[Thiol-selective mechanism of in vitro interaction of serum proteins with adrenaline in IHD patients].
The author demonstrates that patients with ischemic heart disease have phenomenological peculiarities of adaptation by stability of thiol-dependent mechanism of structural-functional condition of blood serum proteins; describes the phenomenon of emergence of free nonprotein SH-groups in protein-free reaction mixtures of the serum varying in adrenaline concentrations in unstable angina pectoris (this phenomenon indicates structural-functional destabilisation of serum proteins and adequate immunopathological process); suggests an alternative method and pathogenetic diagnosis of IHD clinical forms in which thiol-containing analytes serve as molecular markers.
Kostiushov
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D000787:Angina Pectoris / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000737:chemistry / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism*; D006801:Humans; D017202:Myocardial Ischemia / Q000097:blood* / Q000175:diagnosis; D011237:Predictive Value of Tests; D012016:Reference Values; D013438:Sulfhydryl Compounds / Q000032:analysis*
D015415:Biomarkers; D001798:Blood Proteins; D013438:Sulfhydryl Compounds; D004837:Epinephrine