Complete LC/MS analysis of a Tinnevelli senna pod extract and subsequent isolation and identification of two new benzophenone glucosides.
The hydroalcoholic extract of Tinnevelli senna is widely used as a laxative phytomedicine. In order to improve the knowledge of the chemical composition of this extract, LC/MS and LC/MS(n) studies were performed, allowing the on-line identification of most of the known constituents, i. e., flavonoids, anthraquinones and the typical dianthronic sennosides. However, the identity of four compounds could not be ascertained on-line under the given LC/MS conditions. These substances were isolated and their structures elucidated as kaempferol, the naphthalene derivative tinnevellin 8-glucoside and two new carboxylated benzophenone glucosides.
Terreaux
Christian
C
Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, Lausanne, Switzerland.
Wang
Qi
Q
Ioset
Jean-Robert
JR
Ndjoko
Karine
K
Grimminger
Wolf
W
Hostettmann
Kurt
K
D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification*; D002853:Chromatography, Liquid / Q000379:methods; D005419:Flavonoids; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044949:Kaempferols; D013058:Mass Spectrometry / Q000379:methods; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018514:Plant Structures / Q000737:chemistry; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D012676:Senna Extract / Q000737:chemistry / Q000302:isolation & purification*; D029846:Senna Plant
D001577:Benzophenones; D005419:Flavonoids; D005960:Glucosides; D044949:Kaempferols; D009281:Naphthalenes; C459626:cassiaphenone A-2-glucoside; C459625:cassiaphenone B-2-glucoside; C459627:tinnevellin 8-O-glucoside; C047723:benzophenone; C006552:kaempferol; D012676:Senna Extract; D011794:Quercetin