title: Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana Moens ex Trimen.
abstract: In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum.
authors: Department of Life Sciences, Soonchunhyang University, Asan-si, 336-600, Chungnam, Republic of Korea.
authors: Byeoung-Soo
authors: BS
authors: Park
authors: Dae-Young
authors: DY
authors: Kim
authors: Philip J
authors: PJ
authors: Rosenthal
authors: Sun-Chul
authors: SC
authors: Huh
authors: Belinda J
authors: BJ
authors: Lee
authors: Eun -u
authors: E-
authors: Park
authors: Sung-Min
authors: SM
authors: Kim
authors: Jang-Eok
authors: JE
authors: Kim
authors: Mi-Hee
authors: MH
authors: Kim
authors: Tae-Lin
authors: TL
authors: Huh
authors: Young-Jae
authors: YJ
authors: Choi
authors: Ki-Hyung
authors: KH
authors: Suh
authors: Won-Sik
authors: WS
authors: Choi
authors: Sung-Eun
authors: SE
authors: Lee
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis*; D002738:Chloroquine / Q000494:pharmacology; D002930:Cinchona Alkaloids / Q000138:chemical synthesis*; D015195:Drug Design; D004351:Drug Resistance; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010961:Plasmodium / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D002930:Cinchona Alkaloids; D011804:Quinolines; D002738:Chloroquine