title: Physical performance, toxicity, and quality of life as assessed by the physician and the patient.
abstract: The aim of this study was to study the relationship between physician-assessed quality of life parameters, i.e., toxicity and physical performance, and patients' self-reports of their quality of life (QoL). QoL was assessed at baseline and before each treatment, using the EORTC QLQ-C30. The WHO performance score (PS) and toxicity were assessed in physician interviews. The correlations between the WHO PS and the QLQ-C30 functioning scale scores varied from weak to moderate, depending on the scale. Strongest associations were found in physical-, social-, and role functioning, and in the global QoL. The QLQ-C30 nausea/vomiting and diarrhea scales correlated moderately to corresponding WHO scores. A multiple linear regression analysis was used to analyze the contribution of WHO PS and toxicity variables to the global QoL. The best model explained only 16% of the variance of the global QoL score. The present findings highlight the importance of independent QoL assessments focused on those aspects of QoL not captured in clinical interviews with the physician.
authors: Department of Psychology, University of Helsinki, Finland. minna-liisa.luoma@helsinki.fi
authors: Minna-Liisa
authors: ML
authors: Luoma
authors: Liisa
authors: L
authors: Hakamies-Blomqvist
authors: Johanna
authors: J
authors: Sjöström
authors: Hennig
authors: H
authors: Mouridsen
authors: Anna
authors: A
authors: Pluzanska
authors: Per
authors: P
authors: Malmström
authors: Nils Olof
authors: NO
authors: Bengtsson
authors: Ragnar
authors: R
authors: Hultborn
authors: Björn
authors: B
authors: Ostenstaad
authors: Ingvil
authors: I
authors: Mjaaland
authors: Vahur
authors: V
authors: Valvere
authors: Erik
authors: E
authors: Wist
authors: Gudjon
authors: G
authors: Baldursson
authors: Johan
authors: J
authors: Ahigren
authors: Carl
authors: C
authors: Blomqvist
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000523:psychology*; D003967:Diarrhea / Q000139:chemically induced; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care; D010809:Physical Fitness; D011788:Quality of Life; D012647:Self-Assessment; D011795:Surveys and Questionnaires
chemical_list: D000903:Antibiotics, Antineoplastic; D005472:Fluorouracil; D008727:Methotrexate