Induction of oxidative stress in paraquat formulating workers.
Paraquat as a bipyridyl compound is widely used as an effective herbicide worldwide. In this study, oxidative stress was investigated in blood samples of workers in a pesticide factory, formulating paraquat products for use in agriculture. Controls were age-matched workers with no history of pesticide exposure. They were measured for lipid peroxidation (LPO), antioxidant power and total thiol (SH) groups in blood. The results expressed as mean+/-SD show induction of oxidative stress in workers as revealed by increased plasma LPO (11.46+/-0.99 vs 10.11+/-0.69, P<0.001), decreased plasma antioxidant capacity (1.35+/-0.03 vs 1.54+/-0.05, P<0.001) and plasma SH groups (0.16+/-0.01 vs 0.21+/-0.01, P<0.001) in comparison to those of controls. It is concluded that paraquat-formulating factory workers have elevated LPO and decreased antioxidant power, which may put them in further consequences of oxidative stress.
Ranjbar
Akram
A
Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Iran.
Pasalar
Parvin
P
Sedighi
Alireza
A
Abdollahi
Mohammad
M
D000328:Adult; D002617:Chemical Industry; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry; D006540:Herbicides / Q000009:adverse effects*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D018384:Oxidative Stress / Q000187:drug effects*; D010269:Paraquat / Q000009:adverse effects*; D012189:Retrospective Studies; D013438:Sulfhydryl Compounds; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D005290:Ferric Compounds; D006540:Herbicides; D013438:Sulfhydryl Compounds; D017392:Thiobarbituric Acid Reactive Substances; D010269:Paraquat