CJ-21,164, a new D-glucose-6-phosphate phosphohydrolase inhibitor produced by a fungus Chloridium sp.
A new D-glucose-6-phosphate phosphohydrolase (G6Pase) inhibitor, CJ-21,164 (1) was isolated from the fermentation broth of the fungus Chloridium sp. CL48903. The structure was elucidated to be a novel tetramer of the salicylic acid derivatives by spectroscopic analyses. Compound I inhibited G6Pase in rat liver microsomes with an IC50 of 1.6 microM. Glucose output from hepatocytes isolated from rat liver was inhibited when I was present in the incubation medium, consistent with the role of I as a G6Pase inhibitor.
Kim
Yoon-Jeong
YJ
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc, Chita-gun, Aichi, Japan. Yoon-Jeong.Kim@japan.pfizer.com
Nishida
Hiroyuki
H
Pang
Chang-Hong
CH
Saito
Toshiyuki
T
Sakemi
Shinichi
S
Tonai-Kachi
Hiroko
H
Yoshikawa
Nobuji
N
Vanvolkenburg
Maria A
MA
Parker
Janice C
JC
Kojima
Yasuhiro
Y
D000818:Animals; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005947:Glucose / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D015394:Molecular Structure; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001565:Benzoates; C455259:CJ 21164; D004791:Enzyme Inhibitors; D010744:Phosphoric Monoester Hydrolases; D005947:Glucose