title: Activation of cartilage-derived morphogenetic protein-1 in torn rotator cuff.
abstract: Localization and expression of cartilage-derived morphogenetic protein-1 in tissues of torn rotator cuff tendons were examined by in situ hybridization and immunohistochemical analysis. Histologic findings of torn rotator cuff tendons showed that active cells synthesizing the alpha-1 chain of collagen Type I messenger ribonucleic acid were localized predominantly in the torn edge and in the bursa side rather than in the joint side, and scarcely localized in a site distant from the torn edge. Cartilage-derived morphogenetic protein-1 had a similar distribution as the alpha-1 chain of collagen Type I. The current findings provide the first observational evidence that cartilage-derived morphogenetic protein-1 was activated specifically at the site of the torn rotator cuff tendon. The current findings suggest that the cells in the torn rotator cuffs are capable of synthesizing cartilage-derived morphogenetic protein-1, one of the known essential factors for tendon formation.
authors: Department of Orthopaedic Surgery, Osaka University Medical School, 2-2 Yamadaoka, Suita 565-0871, Japan.
authors: Takanobu
authors: T
authors: Nakase
authors: Kazuomi
authors: K
authors: Sugamoto
authors: Takashi
authors: T
authors: Miyamoto
authors: Noriyuki
authors: N
authors: Tsumaki
authors: Frank P
authors: FP
authors: Luyten
authors: Hiroaki
authors: H
authors: Inui
authors: Akira
authors: A
authors: Myoui
authors: Tetsuya
authors: T
authors: Tomita
authors: Hideki
authors: H
authors: Yoshikawa
mesh_terms: D000368:Aged; D019485:Bone Morphogenetic Proteins; D024042:Collagen Type I / Q000032:analysis / Q000378:metabolism*; D046508:Culture Techniques; D005260:Female; D055428:Growth Differentiation Factor 5; D006133:Growth Substances / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D012038:Regeneration / Q000502:physiology*; D017006:Rotator Cuff / Q000473:pathology* / Q000502:physiology; D000070636:Rotator Cuff Injuries; D012680:Sensitivity and Specificity
chemical_list: D019485:Bone Morphogenetic Proteins; D024042:Collagen Type I; D055428:Growth Differentiation Factor 5; D006133:Growth Substances