Muscle metabolism and exercise tolerance in COPD.
This article explores the hypothesis that dyspnea in patients with COPD arises from an imbalance between the load placed on the respiratory muscle pump and its capacity. Evidence to support this concept is presented, and possible therapeutic approaches are discussed.
Polkey
Michael I
MI
Royal Brompton Hospital, Fulham Road, London SW3 6NP, UK. m.polkey@rbh.nthames.nhs.uk
D005081:Exercise Therapy; D017079:Exercise Tolerance; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism / Q000503:physiopathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology* / Q000534:rehabilitation; D015656:Respiratory Mechanics; D012132:Respiratory Muscles / Q000378:metabolism / Q000503:physiopathology*