Role of oxidized low-density lipoprotein in renal disease.
Accelerated atherosclerosis is often observed in patients with chronic renal failure. In the present review we summarize and discuss the recent literature on the pathogenic role of low-density lipoproteins modified by oxidative processes in atherosclerosis and the possible role in renal diseases. Pathogenetically, the oxidation of low-density lipoproteins is considered to be a key event in the development of atherosclerosis, in part by causing enhanced uptake of lipids by macrophages. In addition, oxidation of low-density lipoproteins exerts cytotoxic, proinflammatory and immunogenic properties, all of which could potentially contribute to the development and progression of atherosclerosis.
Heeringa
Peter
P
Department of Clinical and Experimental Immunology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands. p.heeringa@immuno.unimaas.nl
Tervaert
Jan W Cohen
JW
D001323:Autoantibodies / Q000276:immunology; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000276:immunology; D008077:Lipoproteins, LDL / Q000378:metabolism*; D010084:Oxidation-Reduction
D001323:Autoantibodies; D008077:Lipoproteins, LDL