Coeliac disease--all questions answered?
Gliadin specific T cells in the small intestines of coeliac disease patients use the disease associated human leukocyte antigen-DQ2 molecules in their antigen recognition. In an exciting interplay with tissue transglutaminase, the immune system recognises modified gliadin peptides and mounts a phlogistic response. Moreover, the role for autoimmune phenomena and the mechanism of breaking of immunological tolerance remain elusive.
Lundin
K E A
KE
Department of Medicine and Institute of Immunology, Rikshospitalet and University of Oslo, Norway. knutlundin@rikshospitalet.no
D000818:Animals; D002446:Celiac Disease / Q000276:immunology*; D000939:Epitopes; D005903:Gliadin / Q000276:immunology; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology; D011503:Transglutaminases / Q000502:physiology
D000939:Epitopes; D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; D005903:Gliadin; D011503:Transglutaminases