title: Helicobacter pylori infection is not associated with delayed gastric emptying or upper gastrointestinal symptoms in diabetes mellitus.
abstract: This study evaluated the relationship between gastric emptying and upper gastrointestinal symptoms with H. pylori status in patients with diabetes mellitus. Sixty-three outpatients (44 type 1, 19 type 2, age 45 +/- 1.5 years) underwent measurements of gastric emptying of a mixed solid and liquid meal, gastrointestinal symptoms (gastric and esophageal), glycemic control (HbA1c), and autonomic nerve function. Anti-H. pylori IgG antibodies were quantified using a validated kit. Gastric emptying of solid and/or liquid was delayed in 47 (75%) patients, and 31 (49%) had autonomic neuropathy. Fifteen (24%) of the patients were H. pylori positive. There were no differences in gastric emptying (solid retention at 100 min: 67.5 +/- 5.7% vs 63.2 +/- 3.6%; P = 0.63, liquid T50: 35.5 +/- 2.9 min vs 42.5 +/- 3.4 min; P = 0.42), upper gastrointestinal symptoms (gastric 3.9 +/- 0.7 vs 4.0 +/- 0.4; P = 0.94 or esophageal 1.7 +/- 0.5 vs 1.3 +/- 0.2; P = 0.42) or HbA1c (8.8 +/- 0.4% vs 8.6 +/- 0.2%; P = 0.89) between H. pylori-positive and -negative patients. We conclude that H. pylori infection is not associated with delayed gastric emptying or upper gastrointestinal symptoms in diabetes.
authors: Department of Medicine, University of Adelaide, Royal Adelaide Hospital, SA, Australia.
authors: Karen L
authors: KL
authors: Jones
authors: Judith M
authors: JM
authors: Wishart
authors: Melanie
authors: M
authors: Berry
authors: Antonietta
authors: A
authors: Russo
authors: Harry Hua-Xiang
authors: HH
authors: Xia
authors: Nicholas J
authors: NJ
authors: Talley
authors: Michael
authors: M
authors: Horowitz
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000382:microbiology*; D005260:Female; D005746:Gastric Emptying; D005767:Gastrointestinal Diseases / Q000150:complications* / Q000382:microbiology*; D006442:Glycated Hemoglobin / Q000032:analysis; D016481:Helicobacter Infections / Q000150:complications* / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin