Citalopram has an antagonistic action on cortical spreading depression in well-nourished and early-malnourished adult rats.
Adult, well-nourished (W) and early-malnourished (M) male Wistar rats were injected intraperitoneally for 7 days with 20 mg/kg CIT and cortical spreading depression (CSD) was recorded for 4 h on the day following the treatment. M-animals presented lower body weights, as well as higher CSD velocities of propagation, than the W ones, as previously reported. Compared to saline-injected controls, rats treated with CIT for 7 days presented comparable body weights and lower mean CSD velocities, per hour of recording, the differences being significant at the second hour (3.29+/-0.31 versus 3.56+/-0.40 mm/min; P < 0.05). Topical, cortical application of CIT (1- and 5 mg/ml solutions over the intact dura-mater) reduced dose-dependently the CSD velocity (maximal reductions of 16.3 and 55.8% for the 1 and 5 mg/ml solutions, respectively; P < 0.05), as well as the amplitude of the CSD-slow potential change (58.2 and 88.3%). In three out of seven W-rats and in one out of seven M-rats, topical CIT (5 mg/ml) blocked CSD propagation. The effects were reverted by flushing the treated region with saline. In the M-groups, CIT affected CSD in the same manner as in the W ones. The results reinforce previous evidence for an antagonistic influence of the serotoninergic activity on CSD.
Guedes
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RC
Departamento de Nutrição, Universidade Federal de Pernambuco, Recife, Brazil. rguedes@npd.ufpe.br
Amâncio-Dos-Santos
A
A
Manhães-De-Castro
R
R
Costa-Cruz
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RR
D000818:Animals; D001835:Body Weight; D015283:Citalopram / Q000494:pharmacology*; D013181:Cortical Spreading Depression / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D009748:Nutrition Disorders / Q000503:physiopathology*; D051381:Rats; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors