Calorimetric studies of diclofenac sodium in aqueous solution of cyclodextrin and water-ethanol mixtures.
The technique of solution calorimetry has been employed to study the interaction between diclofenac sodium and beta-cyclodextrin by determining the enthalpies of solution of the drug in water and in aqueous beta-cyclodextrin solution. Thermodynamic parameters characterizing the binding process such as enthalpy deltaH0, equilibrium constant K, free energy deltaG0 and entropy deltaS0 have been calculated to be 12.00 kJ mol(-1), 1670 dm3 mol(-1), -19.03kJ mol(-1) and 22.98 J K(-1) mol(-1), respectively. Enthalpies of solution of diclofenac sodium have also been determined in water-ethanol mixtures.
Chadha
R
R
Pharmaceutical Chemistry Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Kashid
N
N
Kumar
A
A
Jain
D V S
DV
D000465:Algorithms; D002151:Calorimetry / Q000379:methods; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002627:Chemistry, Physical; D003505:Cyclodextrins / Q000737:chemistry*; D004008:Diclofenac / Q000737:chemistry*; D019277:Entropy; D000431:Ethanol / Q000737:chemistry*; D006358:Hot Temperature; D012995:Solubility; D013816:Thermodynamics; D014867:Water / Q000737:chemistry*; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D014867:Water; D004008:Diclofenac; D000431:Ethanol; C031215:betadex