title: [Expression and clinical significance of MAGE-4 gene in human hepatocellular carcinoma].
abstract: OBJECTIVE
  To explore the possibility of MAGE-4 gene encoding protein used as a target for immunotherapy in HCC patients.
  
  
  METHODS
  The expression of MAGE-4 gene in tumor tissues and tumor adjacent non-HCC liver tissues was examined by the RT-PCR method. The relationship between positive expression rate of MAGE-4 gene and other clinical and lab data including AFP, AFU, anti-HCV, HBsAg, AFP mRNA, and the diameter of the tumors in HCC patients was also determined.
  
  
  RESULTS
  The positive expression rate of MAGE-4 gene was significantly higher in the tumor than in tumor surrounding tissues (38.7% vs 0%, P<0.01), while the positive expression rate of MAGE-4 gene had no relationship with the clinical and lab data (P>0.05).
  
  
  CONCLUSIONS
  The high frequency of MAGE-4 gene expression in HCC suggests the possibility of MAGE-4 gene encoding protein as a target for immunotherapy in HCC patients, but the expression has no relationship with the tumor metastasis and the recurrence of HCC.
authors: Department of Liver Surgery, Liver Cancer Institute, Post & Telecomm General Hospital, 8th School of Medicine of Peking University, Beijing 100032, China.
authors: Haitao
authors: H
authors: Zhao
authors: Jing'an
authors: J
authors: Rui
authors: Xu
authors: X
authors: Cong
authors: Yi
authors: Y
authors: Zhao
authors: Shaobin
authors: S
authors: Wang
authors: Shuguang
authors: S
authors: Chen
authors: Yu
authors: Y
authors: Wang
authors: Yu
authors: Y
authors: Wang
authors: Xisheng
authors: X
authors: Leng
authors: Weifeng
authors: W
authors: Chen
mesh_terms: D000951:Antigens, Neoplasm; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology*; D009363:Neoplasm Proteins / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D000951:Antigens, Neoplasm; C095204:MAGEA4 protein, human; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm