Local photodynamic therapy reduces tissue hyperplasia after stenting in an experimental restenosis model.
Local photodynamic therapy was used to prevent neointimal hyperplasia after stenting. Slotted tube stents were placed with 16 atmospheres in porcine femoral arteries with the external diameter to match the diameter at 10 atmospheres. Animals were randomly allocated to Group 1 (stenting only); or Group 2 with stenting, local drug delivery of a photosensitizer (5 mg Photofrin) and subsequent exposure to light (photodynamic therapy, 100 J). Fourteen days later, all vessels were excised, fixed and processed for histology. Tissue hyperplasia was observed after stenting in vessels from Group 1. In Group 2 with photodynamic therapy, the myoproliferative response was significantly reduced. Tissue hyperplasia after stenting was effectively suppressed by photodynamic therapy.
Valassis
Grigorios
G
Institute of Anatomy, University Munich, Germany.
Pragst
Ingo
I
Adolfs
Christian
C
Paclik
Daniela
D
Wiens
Franziska
F
Vogel-Wiens
Claudia
C
Milz
Stefan
S
Gonschior
Peter
P
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003131:Combined Modality Therapy; D003327:Coronary Disease / Q000188:drug therapy / Q000473:pathology; D023903:Coronary Restenosis / Q000188:drug therapy* / Q000473:pathology; D017323:Dihematoporphyrin Ether / Q000494:pharmacology*; D005263:Femoral Artery / Q000473:pathology; D006965:Hyperplasia; D010778:Photochemotherapy; D015607:Stents; D013552:Swine
D000970:Antineoplastic Agents; D017323:Dihematoporphyrin Ether