title: "Senseless" antiviral polyribonucleotides: poly (1-propargylinosinic acid).
abstract: Previous work has shown that novel amphipathic oligo and polyribonucleotides exhibiting secondary structure in solution are potent inhibitors of HIV and HCMV replication and cytopathicity in tissue culture. It was hypothesized that the mechanism(s) of action for these compounds might be inhibition of retroviral reverse transcriptase (RT) and/or viral uptake by cells. Pursuit of the essential pharmacophore has led to the discovery of poly (1-propargylinosinic acid) (10), an HIV and HCMV-active polyribonucleotide lacking the secondary structure previously thought to be essential for the observed antiviral activity.
authors: Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112-9453, USA.
authors: Robyn M
authors: RM
authors: Hyde
authors: Robert W
authors: RW
authors: Buckheit
authors: Arthur D
authors: AD
authors: Broom
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects; D009705:Nucleosides / Q000737:chemistry; D011131:Polyribonucleotides / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents; D009705:Nucleosides; D011131:Polyribonucleotides