title: Translocation der(13;21)(q10;q10) in skeletal and extraskeletal mesenchymal chondrosarcoma.
abstract: Cytogenetic studies of mesenchymal chondrosarcoma are few and to date, no specific or recurrent aberrations have been found. In this investigation, the cytogenetic and molecular cytogenetic (spectral karyotypic and fluorescence in situ hybridization) findings for two mesenchymal chondrosarcomas, one arising skeletally and the other extraskeletally, are reported. An identical Robertsonian translocation involving chromosomes 13 and 21 [der(13;21)(q10;q10)] was detected in both cases, possibly representing a characteristic rearrangement for this histopathologic entity. Both cases also exhibited loss of all or a portion of chromosomes 8 and 20 and gain of all or a portion of chromosome 12. The observation of similar chromosomal abnormalities in both skeletal and extraskeletal mesenchymal chondrosarcoma supports a genetic as well as histopathologic relationship between these anatomically distinct neoplasms.
authors: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
authors: Sabine
authors: S
authors: Naumann
authors: Pamela A
authors: PA
authors: Krallman
authors: K Krishnan
authors: KK
authors: Unni
authors: Mary E
authors: ME
authors: Fidler
authors: James R
authors: JR
authors: Neff
authors: Julia A
authors: JA
authors: Bridge
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000235:genetics / Q000473:pathology*; D018211:Chondrosarcoma, Mesenchymal / Q000235:genetics / Q000473:pathology*; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic