Sex and the single (double-strand) break.
It has been known for some time that DNA double-strand breaks (DSBs) initiate homologous recombination during meiosis. Two recent studies show that the fate of a single DSB in yeast is strongly influenced by the presence of other breaks in the genome, hinting that cell-wide or chromosome-regional mechanisms control the outcome of DSB repair.
Martini
Emmanuelle
E
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
Keeney
Scott
S
D019457:Chromosome Breakage; D015825:Chromosomes, Fungal / Q000235:genetics* / Q000648:ultrastructure; D003434:Crossing Over, Genetic / Q000235:genetics; D004260:DNA Repair; D004271:DNA, Fungal / Q000235:genetics; D004706:Endodeoxyribonucleases / Q000502:physiology*; D004950:Esterases / Q000502:physiology; D008540:Meiosis / Q000235:genetics*; D008938:Mitosis / Q000235:genetics; D006180:Proton-Translocating ATPases; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*; D013573:Synaptonemal Complex / Q000502:physiology; D000099257:Meiotic Recombination Protein SPO11
D004271:DNA, Fungal; D004706:Endodeoxyribonucleases; D004950:Esterases; D006180:Proton-Translocating ATPases; D029701:Saccharomyces cerevisiae Proteins; D000099257:Meiotic Recombination Protein SPO11; C081687:VMA1 protein, S cerevisiae