The role of innate mediators in inflammatory response.
Cytokines produced by innate immune response can profoundly influence the subsequent adaptive immunity. IL-15 and -18 are two of several mediators produced by macrophages that perform such a function. Here we present recent data mainly from our own laboratory illustrating the important role of IL-15 and -18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis.
Liew
Foo Y
FY
Department of Immunology and Bacteriology, University of Glasgow, G11 6NT, UK. fyllh@clinmed.gla.ac.uk
McInnes
Iain B
IB
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D019409:Interleukin-15 / Q000502:physiology*; D020382:Interleukin-18 / Q000502:physiology*; D008264:Macrophages / Q000276:immunology; D018448:Models, Immunological; D013583:Synovial Membrane / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D019409:Interleukin-15; D020382:Interleukin-18