title: Troponin T concentrations 72 hours after myocardial infarction as a serological estimate of infarct size.
abstract: BACKGROUND
  After acute myocardial infarction, the structural protein T is released considerably longer than cytosolic creatine kinase (CK), CK MB isoenzyme (CK-MB), or lactate dehydrogenase (LDH) and late troponin T release (> 48 hours after onset of chest pain) appears to be less affected by early coronary reperfusion.
  
  
  OBJECTIVE
  To investigate the precision of a single measurement of circulating troponin T concentrations 72 hours after onset of chest pain compared with standard scintigraphic and enzymatic estimates of myocardial infarct size.
  
  
  METHODS
  Quantitative single photon emission computed tomography thallium-201 scintigraphy at rest was performed in 37 patients 2-3 weeks after myocardial infarction (group 1: 14 patients without early coronary reperfusion; group 2: 23 patients with early reperfusion achieved by thrombolytic therapy, by percutaneous transluminal coronary angioplasty, or by both).
  
  
  RESULTS
  In both groups, the number of myocardial segments with abnormal thallium-201 uptake indicating the individual extent of irreversible myocardial damage correlated significantly with the troponin T concentrations 72 hours after infarction as well as with peak concentrations of CK, CK-MB, and LDH.
  
  
  CONCLUSIONS
  The data show that a single measurement of circulating troponin T 72 hours after onset of chest pain--independent of reperfusion--is superior for the estimation of myocardial infarct size to measurement of peak CK, CK-MB, or LDH, which require serial determinations and depend on coronary reperfusion.
authors: Department of Cardiology, University of Heidelberg, Heidelberg, Germany.
authors: M
authors: M
authors: Licka
authors: R
authors: R
authors: Zimmermann
authors: J
authors: J
authors: Zehelein
authors: T J
authors: TJ
authors: Dengler
authors: H A
authors: HA
authors: Katus
authors: W
authors: W
authors: Kübler
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D009204:Myocardial Revascularization / Q000379:methods; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes; D015912:Thrombolytic Therapy / Q000379:methods; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D013794:Thallium Radioisotopes; D020107:Troponin T; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form