title: The risk of cardiovascular disease associated with proteinuria in renal transplant patients.
abstract: Proteinuria in the general population has been shown to be associated with cardiovascular disease, which is the main cause of death in renal transplantation. We investigated the effect of proteinuria on cardiovascular disease after renal transplantation in 532 renal transplant patients with functioning grafts for more than 1 year. Patients were classified into two groups depending on the presence of persistent proteinuria. We analyzed graft and patient survival, posttransplantation cardiovascular disease, and main causes of graft loss and death. Five- and 10-year graft and patient survival rates were lower in the group with proteinuria. The main cause of death was vascular disease in both groups. The presence of posttransplantation cardiovascular disease was higher in the group with proteinuria. Persistent proteinuria was associated with graft loss (RR=4.18), patient death (RR=1.92), and cardiovascular disease (RR=2.45). In conclusion, persistent proteinuria was an independent risk factor for increased cardiovascular morbidity and mortality in renal transplant patients.
authors: Nephrology Service, Universitary Hospital Marqués de Valdecilla, INSALUD, Santander 39008, Spain. nefffg@humv.es
authors: Gema
authors: G
authors: Fernández-Fresnedo
authors: Rafael
authors: R
authors: Escallada
authors: Emilio
authors: E
authors: Rodrigo
authors: Angel L M
authors: AL
authors: De Francisco
authors: Julio G
authors: JG
authors: Cotorruelo
authors: Saturnino
authors: S
authors: Sanz De Castro
authors: Jose A
authors: JA
authors: Zubimendi
authors: J C
authors: JC
authors: Ruiz
authors: Manuel
authors: M
authors: Arias
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000145:classification / Q000453:epidemiology*; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology*; D011183:Postoperative Complications / Q000145:classification*; D015995:Prevalence; D011507:Proteinuria; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain; D015996:Survival Rate; D013997:Time Factors; D044465:White People