Acute lethal encephalopathy in systemic juvenile rheumatoid arthritis.
Macrophage activation syndrome is the most common cause of death in children with systemic juvenile rheumatoid arthritis. We present a first patient with systemic juvenile rheumatoid arthritis in which acute necrotizing encephalopathy developed as a complication of macrophage activation syndrome but not of Reye's syndrome. The suspected mechanism of this lethal complication is discussed.
Ueno
Hideki
H
Department of Pediatrics, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Japan.
Katamura
Kenji
K
Hattori
Haruo
H
Yamaguchi
Yoshimichi
Y
Nakahata
Tatsutoshi
T
D001171:Arthritis, Juvenile / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D017809:Fatal Outcome; D006801:Humans; D007223:Infant; D007888:Leigh Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D008262:Macrophage Activation / Q000187:drug effects / Q000276:immunology; D008297:Male