Acute flare-up of conjunctival graft-versus-host disease with eosinophil infiltration in a patient with chronic graft-versus-host disease.
Chronic graft-versus-host disease (cGvHD) is a disabling alloimmune disease. Acute flare-ups of alloimmune reactions can occur even at the chronic clinical stage necessitating modulation of immunosuppression therapy. We studied conjunctival lesions of a patient with an acute flare-up in cGvHD. Along with severe GvHD lesions, biopsies showed eosinophils with pathological signs of activation. Since eosinophil recruitment and activation is observed in flare-ups of patients with autoimmune or inflammatory bowel diseases, we suggest that activated eosinophils in target organs may be a marker of evolutive lesions in alloimmune reactions as in other kinds of inflammatory diseases.
Daneshpouy
M
M
Laboratoire de Recherche Universitaire de Pathologie EA 2378, Institut Universitaire d'Hématologie, Hĵpital Saint-Louis, Paris, France.
Facon
T
T
Jouet
J P
JP
Janin
A
A
D000208:Acute Disease; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002465:Cell Movement; D002908:Chronic Disease; D003229:Conjunctival Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D004804:Eosinophils / Q000473:pathology*; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D014185:Transplantation, Isogeneic / Q000009:adverse effects
D007166:Immunosuppressive Agents