title: Non-secretor status is associated with female acute uncomplicated pyelonephritis.
abstract: OBJECTIVE
  To retrospectively analyse the secretor status in women with acute uncomplicated pyelonephritis, as non-secretors of histo-blood group antigens are reportedly at risk of recurrent urinary tract infections (UTIs).
  
  
  METHODS
  The study included 245 women who had been diagnosed as having acute uncomplicated pyelonephritis in affiliated hospitals over the past 5 years. All women were sent antiseptic swabs, to collect saliva, and a questionnaire to survey their past UTI episodes and menstrual status. Responses with written informed consent were obtained from 106 women (median age 50.5 years, range 17-85). The secretor status was determined using the haemagglutination inhibition assay from the saliva on the swabs.
  
  
  RESULTS
  Forty-four (41%) of the women were non-secretors, a significantly higher frequency than in the (control) Japanese population (217 of 960, 22.6%; P< 0.001). The incidence of non-secretors was significantly higher (P < 0.01) in premenopausal (26 of 46, 57%) than in postmenopausal women (18 of 60, 30%).
  
  
  CONCLUSIONS
  These results suggest that non-secretor status is associated with a genetic susceptibility to acute uncomplicated pyelonephritis, especially in premenopausal women.
authors: Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: S
authors: S
authors: Ishitoya
authors: S
authors: S
authors: Yamamoto
authors: K
authors: K
authors: Mitsumori
authors: O
authors: O
authors: Ogawa
authors: A
authors: A
authors: Terai
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000941:Antigens / Q000032:analysis; D005260:Female; D005915:Globosides; D006386:Hemagglutination Tests / Q000379:methods; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D011704:Pyelonephritis / Q000097:blood / Q000209:etiology*; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D012463:Saliva / Q000737:chemistry*; D014552:Urinary Tract Infections / Q000209:etiology
chemical_list: D000017:ABO Blood-Group System; D000941:Antigens; D005915:Globosides; C037790:sialosylgloboside