title: Characterization of dioxin exposure in firefighters, residents, and chemical workers in the Irkutsk Region of Russian Siberia.
abstract: The goal of this study was to characterize body burdens of polychlorinated dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) in three groups of Siberians living in the Irkutsk Region of Russia. These groups included firefighters exposed to a mixture of toxic substances extinguishing a large fire at the Shelekhovo Cable Factory in 1992, chemical workers from the Khimprom chemical plant, and residents living in proximity to large chemical factories in Sayansk and Angarsk. Blood samples from all groups were obtained in the fall of 1998. Dioxin analyses of samples were performed in Germany, Canada, and in a Russian dioxin laboratory in Ufa, Bashkortostan Republic. The average levels of dioxin toxic equivalents (TEQs) are 23.6 parts per trillion (ppt) total TEQ (PCDD/F only) in the disabled firefighters, 25.0 in the non-disabled firefighters, 28.7 in residents, and 45.6 in the Khimprom workers blood. Two workers did have elevated total TEQs of 91.4 and 102.2 ppt. Dibenzofurans and coplanar PCBs substantially contribute to the total elevated TEQ seen here. The average TEQs suggest levels of dioxin exposure in this part of the former Soviet Union not dissimilar to levels measured in industrialized countries of Europe and Northern America.
authors: University of Texas School of Public Health at Dallas, 75390, USA. arnold.schecter@utsouthwestern.edu
authors: A
authors: A
authors: Schecter
authors: M
authors: M
authors: Pavuk
authors: D A
authors: DA
authors: Amirova
authors: E I
authors: EI
authors: Grosheva
authors: Päpke
authors: J J
authors: JJ
authors: Ryan
authors: J
authors: J
authors: Adibi
authors: A L
authors: AL
authors: Piskac
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000032:analysis* / Q000493:pharmacokinetics; D001822:Body Burden; D002617:Chemical Industry; D000072338:Dibenzofurans, Polychlorinated; D004781:Environmental Exposure; D005260:Female; D005390:Fires; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011078:Polychlorinated Biphenyls / Q000032:analysis* / Q000493:pharmacokinetics; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis* / Q000493:pharmacokinetics; D012800:Siberia; D012989:Soil Pollutants / Q000032:analysis* / Q000493:pharmacokinetics
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants; D011078:Polychlorinated Biphenyls