[Pharmacokinetic of prednisolone in patients with rheumatoid arthritis].
OBJECTIVE
To study pharmacokinetics of prednisolone in patients with rheumatoid arthritis (RA).


METHODS
The examination of 10 RA patients included blood tests for glucocorticoids 1, 2, 4 and 6 hours after the drug intake. Serum steroids were measured using high performance liquid chromatography. Pharmacokinetic parameters were estimated in one-chamber model with absorption.


RESULTS
In spite of the same dose of prednisolone, its serum concentration as well as pharmacokinetic parameters were individual in each patient.


CONCLUSIONS
Pharmacokinetic indices of prednisolone in RA patients provide more reliable information for design of treatment scheme for each patient individually.
Chekalin
A F
AF
Rossokhin
V F
VF
Shishkanov
S F
SF
Nesterov
S L
SL
D000284:Administration, Oral; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics*; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D005260:Female; D005938:Glucocorticoids / Q000493:pharmacokinetics*; D006801:Humans; D008875:Middle Aged; D011239:Prednisolone / Q000493:pharmacokinetics*
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D011239:Prednisolone