A role for CD147 in thymic development.
We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCRbeta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.
Renno
Toufic
T
Centre d'Immunologie Pierre Fabre, 5 Avenue Napoleon III, Saint-Julien en Genevois, 74160 France.
Wilson
Anne
A
Dunkel
Caroline
C
Coste
Isabelle
I
Maisnier-Patin
Karine
K
Benoit de Coignac
Amélie
A
Aubry
Jean-Pierre
JP
Lees
Rosemary K
RK
Bonnefoy
Jean-Yves
JY
MacDonald
H Robson
HR
Gauchat
Jean-François
JF
D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D030161:Avian Proteins; D001483:Base Sequence; D051926:Basigin; D001666:Binding Sites, Antibody / Q000235:genetics; D001798:Blood Proteins; D002453:Cell Cycle / Q000235:genetics / Q000276:immunology; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D002460:Cell Line; D003001:Cloning, Molecular; D005260:Female; D005333:Fetus; D006801:Humans; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D009924:Organ Culture Techniques; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology* / Q000276:immunology* / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D030161:Avian Proteins; C497886:BSG protein, human; D001798:Blood Proteins; C102624:Bsg protein, Gallus gallus; C497887:Bsg protein, mouse; C079432:Bsg protein, rat; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D051926:Basigin