[Prognostic value of P53, Ki67, and Rb protein in infiltrating bladder tumors].
OBJECTIVE
To determinate whether increased expression of the p53 and Ki67 and the of the tumour suppressor gene retinoblastoma (prot Rb), in an immunohistochemistry study, were associated with relapse in invasive bladder cancer.


METHODS
47 patients with invasive bladder cancer. 42 men and 5 women. Mean age 63 years old. Relapse in 19 patients (40%). Mean time until recurrence 8.5 months. p53 and Ki67 were study in 47 patients and prot Rb in 40 patients.


RESULTS
p53: Mean expression 41%. There were significant differences in the increased expression of p53 between patients with and without relapse (p = 0.03). A statistically significant association was then observed between patients with p53 > 20% (vs p53 < 20%) and adverse outcome of the disease (p = 0.04). Ki67 and prot Rb: There were no significant differences in relapse and progression free survival between Ki67 > 40% (vs Ki67 < 40%) and prot Rb < 10% (vs prot Rb > 10%). p53 expression showed a statistically significant correlation with Ki67 and prot Rb.


CONCLUSIONS
p53 is a good prognostic marker for the relapse and progression free survival in invasive bladder cancer.
Sánchez Zalabardo
D
D
Departamento de Urología, Clínica Universitaria, Pamplona, Navarra.
Rosell Costa
D
D
Fernández Montero
J M
JM
López Ferrandis
J
J
Arocena García-Tapia
J
J
Jiménez Garín
S
S
de Alava Casado
E
E
Robles García
J E
JE
Zudaire Bergera
J J
JJ
Berián Polo
J M
JM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016160:Retinoblastoma Protein / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*
D019394:Ki-67 Antigen; D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53