Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis?
Steinberg
Daniel
D
Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of California San Diego, La Jolla, Calif 92093-0682, USA. dsteinberg@ucsd.edu
Witztum
Joseph L
JL
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D008955:Models, Cardiovascular; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D013045:Species Specificity
D000975:Antioxidants; D015415:Biomarkers; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein