title: [Effect of bilirubin derivative on HIV-1 in vitro].
abstract: BACKGROUND
  To study the effect of DTB against HIV-1, for developing anti-HIV drugs.
  
  
  METHODS
  Different concentration of DTB was added to cell culture system after viral inoculation, MTT staining method for viable cells (MTT assay) and p24 (ELISA) were used as markers to monitor the viral replication.
  
  
  RESULTS
  The inhibition rates of DTB at concentrations 160, 80, and 40mg/ml were 93.0%, 56.2% and 18.1%, respectively.
  
  
  CONCLUSIONS
  DTB could effectively inhibit HIV-1 in vitro.
authors: Institute of Virology, Chinese Academy Preventive Medicine, Beijing 100052, China.
authors: Yao
authors: Y
authors: Ye
authors: Qi
authors: Q
authors: Wang
authors: Guomin
authors: G
authors: Chen
authors: Yi
authors: Y
authors: Zhang
authors: Fang
authors: F
authors: Yan
authors: Tianyu
authors: T
authors: Wang
authors: Jinshi
authors: J
authors: Ma
authors: Zelin
authors: Z
authors: Li
authors: Yi
authors: Y
authors: Zeng
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D001663:Bilirubin / Q000031:analogs & derivatives / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques
chemical_list: D019380:Anti-HIV Agents; D001663:Bilirubin