[Isoflavones and calcified tissues].
The data about osteotropic action of isoflavones are presented in this review. Isoflavones are the compounds of phytoestrogenes group--hormone-like bioregulators of plant origin. Animal experiments as well as bone tissue and bone cells cultures investigations demonstrate anabolic effect of isoflavones on bone metabolism. Isoflavones prevent bone loss in ovariectomized animals. They inhibit bone resorbition and enhance bone formation. Because of this natural and synthetic isoflavones hold great promise in the prevention and treatment of osteoporosis. These compounds may also be effective in preventing bone loss associated with hypodynamia or immobility, ovariectomy or postmenopausal hypoestrogenia, chronic corticosteroid use, renal osteodystrophy, hyperparathyroidism and other metabolic disorders affecting the calcified tissues, including alveolar bone loss in periodontal disease as well as dental hard tissues destruction.
Sukmanskiĭ
O I
OI
Institute of Stomatology, Academy of Medical Sciences of Ukraine, Odessa State Agrarian University.
D000375:Aging / Q000473:pathology; D000818:Animals; D001862:Bone Resorption / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D019833:Genistein / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010024:Osteoporosis / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D010052:Ovariectomy
D007529:Isoflavones; C040641:genistin; C013908:daidzin; C004742:daidzein; D019833:Genistein