Molecular mechanisms of "detachment-induced apoptosis--Anoikis".
Apoptosis following loss of cell anchorage is of relevance for development, tissue homeostasis and disease. In the following the role of cell-matrix anchorage as well as cell-cell anchorage for cell survival and apoptosis is reviewed and the complex molecular mechanisms inducing and perpetuating detachment-induced apoptosis will be discussed with special emphasis on the role of caspases, p53, bcl-2 family members and the Fas signaling pathway.
Grossmann
J
J
Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany.
D023102:Anoikis / Q000502:physiology*; D017209:Apoptosis / Q000502:physiology*; D015820:Cadherins / Q000378:metabolism; D020169:Caspases / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic; D006706:Homeostasis; D008954:Models, Biological; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D019014:fas Receptor / Q000378:metabolism
D015820:Cadherins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D019014:fas Receptor; D020169:Caspases