Virological, immunological and host factors in HIV-1 discordant couples in Thailand.
The potential factors of resistance to HIV-1 infection were investigated in 23 HIV discordantly infected couples, of each, one partner had HIV infection and the matched spouse was not infected. Both partners of the HIV discordant couples possessed comparable number of CD4+ cells expressing CCR5. Our study demonstrated that resistance to HIV-1 infection was not due to low level of HIV viral load in their infected-matched spouses. In addition, selective biological phenotype of HIV clinical isolates, which is indicative for risk of transmission, could not be determined in this study. However, we have demonstrated that the unknown genetic factor(s), and neutralizing antibody of broad and high activity could be taken into an account for resistance to HIV infection in the HIV discordant couples.
Louisinrotchanakul
S
S
Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Roongpisuthipong
A
A
Poonarkngeng
R
R
Chaiyakool
P
P
Sangswang
S
S
Wasi
C
C
D000906:Antibodies / Q000097:blood; D018562:Disease Transmission, Infectious; D005260:Female; D015686:Gene Products, env / Q000276:immunology; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics / Q000276:immunology* / Q000635:transmission* / Q000821:virology; D018023:HIV Seronegativity; D006679:HIV Seropositivity; D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D020010:Heterosexuality; D006801:Humans; D008297:Male; D009500:Neutralization Tests; D018454:Spouses; D013785:Thailand; D019562:Viral Load
D000906:Antibodies; D015686:Gene Products, env