Preparation and cytotoxic activity of some new rhodomycin derivatives bearing modifications in the sugar moiety.
The synthesis and structural determination of a number of new rhodomycin derivatives, modified in the sugar part are described. The cytotoxicity against leukemic L1210 cells of these compounds is reported, along with beta-rhodomycinone and two regioisomers of the above compounds, which were isolated during the synthetic procedure.
Algiannis
Nectarios
N
University of Athens, Department of Pharmacy, Greece.
Pouli
Nicole
N
Marakos
Panagiotis
P
Skaltsounis
Alexios-Leandros
AL
Florent
Jean-Claude
JC
Perchellet
Elisabeth M
EM
Sperfslage
Bonnie J
BJ
McIlvain
Corbin J
CJ
Perchellet
Jean-Pierre
JP
D000818:Animals; D018943:Anthracyclines / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; C004977:rhodomycin