"Seeing inside the body": MR imaging of gene expression.
The goal of this review is to describe the developments and recent advances that are enabling applications of magnetic resonance (MR) imaging for non-invasive imaging of gene expression. Guiding application of this technology has been the need to test, in vivo and in real time, hypotheses developed in multiple scientific fields. Advances made in the human genome project and our increasing understanding of the molecular basis of normal and disease physiology have defined questions that will only be answered when specific molecular imaging modalities are developed. In this review we will briefly summarize the salient features of MR imaging to provide the backdrop for a more detailed discussion of specific applications of MR imaging of gene expression. We will conclude with the insights gained from genomic approaches and how they might be exploited for MR imaging of gene expression in the future.
Högemann
Dagmar
D
Center for Molecular Imaging Research, NFCR Center for Molecular Analysis and Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Basilion
James P
JP
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods; D020869:Gene Expression Profiling / Q000379:methods* / Q000639:trends*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000639:trends*; D008957:Models, Genetic; D008958:Models, Molecular; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods; D019076:Transgenes / Q000235:genetics