[Efficacy of specific immunotherapy in children with seasonal allergic rhinitis and conjunctivitis, sensitized to grass pollen].
The aim of this study was the evaluation of efficacy of the specific immunotherapy using Pollinex for 3 years before the period of pollen dust in children with seasonal allergic rhinitis and conjunctivitis induced by grass pollen. The study was carried out in a group of 40 children aged 5-18 years, from the Outpatient Department of Immunology at the National Research Institute of Mother and Child. The children demonstrated clinical symptoms of seasonal allergic rhinitis with conjunctivitis and had a medical history typical for this disease. Diagnostic procedures including skin prick tests and estimation of specific IgE to grass pollen by Pharmacia - CAP system, gave positive results. The efficacy of therapy was monitored by a clinical score with 4-0 points, recording symptoms relating to intensity of rhinoedema, rhinorrhea, sneezing, itching, oedema, conjunctival congestion, pain and lacrimation. In the study group, 39 children (97%) with seasonal rhinitis and conjunctivitis treated by specific immunotherapy (Pollinex) improved. This was confirmed by a statistically significant difference. The results indicate that the specific immunotherapy is an effective treatment of seasonal allergic rhinitis with conjunctivitis in children sensitized to grass pollen.
Bulawa
E
E
Zaklad Immunologii, Instytut Matki i Dziecka, Kasprzaka 17a, 01-211 Warszawa, Poland. immunolog@imid.med.pl
Borysewicz
G
G
Markiewicz
K
K
Derentowicz
P
P
D000293:Adolescent; D000485:Allergens / Q000627:therapeutic use*; D052179:Antigens, Plant / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003233:Conjunctivitis, Allergic / Q000188:drug therapy* / Q000453:epidemiology; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D006109:Poaceae / Q000009:adverse effects*; D011044:Poland / Q000453:epidemiology; D011058:Pollen / Q000009:adverse effects*; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy* / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome
D000485:Allergens; D052179:Antigens, Plant; D010936:Plant Extracts; C014155:Parietaria judaica pollen