Hospital-based diagnosis of hemorrhagic fever, encephalitis, and hepatitis in Cambodian children.
Surveillance was conducted for three clinical syndromes (hemorrhagic fever, encephalitis, and hepatitis) in Cambodian children admitted to the National Pediatric Hospital in Phnom Penh from July 1996 through September 1998. Acute- and convalescent-phase sera, and cerebrospinal fluid, when applicable, underwent diagnostic evaluation for infections with Dengue virus (DENV), Japanese encephalitis virus (JEV), and Hepatitis A, B, C, and E viruses. Of 621 children admitted with hemorrhagic fever, 499 (80%) were confirmed to have either primary or secondary DENV infection. DENV rates were as high as 10.6/100 hospital admissions in September 1998. Of 50 children with clinical encephalitis, 9 (18%) had serologic evidence of JEV infection. Forty-four children had clinical hepatitis, most (55%) due to Hepatitis A virus (HAV). One patient had Hepatitis B virus, and no patients had hepatitis C or E. This study identified a large number of children with vaccine-preventable diseases (JEV and HAV).
Chhour
Y Meng
YM
National Pediatric Hospital, Phnom Penh, Cambodia.
Ruble
Gaye
G
Hong
Rathavuth
R
Minn
Kyi
K
Kdan
Yuvatha
Y
Sok
Touch
T
Nisalak
Ananda
A
Myint
Khin Saw Aye
KS
Vaughn
David W
DW
Endy
Timothy P
TP
D000293:Adolescent; D002160:Cambodia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004660:Encephalitis / Q000175:diagnosis / Q000453:epidemiology*; D006482:Hemorrhagic Fevers, Viral / Q000175:diagnosis / Q000453:epidemiology*; D006505:Hepatitis / Q000175:diagnosis / Q000453:epidemiology*; D006761:Hospitals; D006801:Humans; D007223:Infant; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D015995:Prevalence; D012703:Serotyping