General screening for celiac disease is advisable in children with type 1 diabetes.
The association between celiac disease (CD) and diabetes mellitus type 1 is well known. Only about one-third of all patients with CD are diagnosed in childhood as a result of typical gastrointestinal symptoms or growth retardation. To evaluate the feasibility of CD screening in diabetic children, we tested autoantibodies to tissue transglutaminase (tTGA) in all children with type 1 diabetes from our pediatric department during a 12-month period. In antibody-positive cases, we analyzed the clinical presentation and offered a duodenal biopsy to confirm the diagnosis and grade the severity of the inflammatory process. Of 205 children, 13 (6.3 %) were tTGA-positive. In seven of eight children who agreed to perform a biopsy, CD typical histological signs were detected (Marsh 1: n = 1, Marsh 3: n = 6). In three patients with confirmed disease, symptoms (iron deficiency, recurrent abdominal pain) remained undiscovered up to time of screening (latent form); in four, the disease was asymptomatic (silent form). Since clinical symptoms are mostly mild or absent in spite of severe signs of duodenal inflammation, we recommend tTGA screening in all diabetic children. This strategy may allow the identification of patients in an early stage in respect of prevention of long-term complications.
Spiekerkoetter
U
U
Heinrich-Heine University Hospital, Department of Pediatrics, Düsseldorf, Germany. ute.spiekerkoetter@mcmail.vanderbilt.edu
Seissler
J
J
Wendel
U
U
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000276:immunology; D001706:Biopsy; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis* / Q000201:enzymology / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000201:enzymology / Q000276:immunology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology; D008297:Male; D011503:Transglutaminases / Q000097:blood / Q000276:immunology
D001323:Autoantibodies; D011503:Transglutaminases