Osteosarcoma and fibrosarcoma caused by postoperative radiotherapy for a pituitary adenoma. Case report.
Sarcomatous change is a rare complication of postoperative radiotherapy for pituitary adenomas. The authors report on what they believe to be the first case in which fibrosarcoma and, later, osteosarcoma developed during a 14-year period following surgery and radiotherapy for a nonsecreting pituitary macroadenoma.
Gnanalingham
Kanna K
KK
Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom. kannagnana@hotmail.com
Chakraborty
Aabir
A
Galloway
Malcolm
M
Revesz
Tamas
T
Powell
Michael
M
D000236:Adenoma / Q000532:radiotherapy*; D000368:Aged; D005260:Female; D005354:Fibrosarcoma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009381:Neoplasms, Radiation-Induced / Q000473:pathology; D012516:Osteosarcoma / Q000209:etiology* / Q000473:pathology; D010911:Pituitary Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects*; D012888:Skull Neoplasms / Q000209:etiology* / Q000473:pathology