title: Transcription factors and neoplasia: vistas in novel drug design.
abstract: OBJECTIVE
  The fundamental role of gene transcription and the recognition of transcription factors as important control elements of cell growth, differentiation, and programmed cell death (apoptosis) aroused an ever-increasing interest for these proteins as potential pharmaceutical targets for therapeutic intervention in various diseases, among them cancer. EXPERIMENTAL DESIGN-RESULTS: The vast array of information available for their molecular architecture and mode of action in various biological contexts, combined with the new opportunities offered by the flourishing technologies of structure-based drug design, computer-aided modeling, and functional genomics/proteomics, are creating an exciting scenery for the development of a novel generation of highly selective drugs.
  
  
  CONCLUSIONS
  This transcription factor-based therapeutic approach may revolutionize the anticancer drug options and will add significantly to the current clinical armamentarium.
authors: Department of Biochemistry, School of Medicine, University of Patras, GR-26110, Greece.
authors: Mihalis V
authors: MV
authors: Karamouzis
authors: Vassilis G
authors: VG
authors: Gorgoulis
authors: Athanasios G
authors: AG
authors: Papavassiliou
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015195:Drug Design; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D014157:Transcription Factors / Q000187:drug effects* / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D014157:Transcription Factors