title: [Detection of serum free insulin-like growth factor 1 in patients with chronic viral hepatitis].
abstract: OBJECTIVE
  To evaluate the serum free insulin-like growth factor 1 (IGF-1) level and its relation with the severity and prognosis in patients with chronic viral hepatitis, liver cirrhosis and severe chronic hepatitis.
  
  
  METHODS
  Serum free IGF-1 was detected by ELISA in 43 patients with chronic viral hepatitis, 20 with liver cirrhosis and 12 with chronic severe hepatitis.
  
  
  RESULTS
  Serum free IGF-1 was significantly decreased in patients with liver cirrhosis and severe chronic hepatitis. Five patients with chronic severe hepatitis whose serum free IGF-1 was lower than 0.2 ng/l died during follow-up. Four patients whose serum free IGF-1 above 0.3 ng/l survived. Serum free IGF-1 was significantly reduced in patients with albumin lower than 30 g/l.
  
  
  CONCLUSIONS
  Serum free IGF-1 is decreased in patients with liver cirrhosis and severe chronic hepatitis and it can predict the prognosis of patients with severe chronic hepatitis.
authors: The 302nd Hospital of PLA, Beijing 100039, China.
authors: M
authors: M
authors: Lou
authors: N
authors: N
authors: Song
authors: X
authors: X
authors: Jin
authors: S Q
authors: SQ
authors: Luo
authors: J J
authors: JJ
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006521:Hepatitis, Chronic / Q000097:blood*; D006525:Hepatitis, Viral, Human / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D007334:Insulin-Like Growth Factor I