Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.
Esler
William P
WP
Das
Chittaranjan
C
Campbell
William A
WA
Kimberly
W Taylor
WT
Kornilova
Anna Y
AY
Diehl
Thekla S
TS
Ye
Wenjuan
W
Ostaszewski
Beth L
BL
Xia
Weiming
W
Selkoe
Dennis J
DJ
Wolfe
Michael S
MS
D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D002460:Cell Line; D003374:Coumarins / Q000737:chemistry / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000378:metabolism*; D006801:Humans
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D003374:Coumarins; D004791:Enzyme Inhibitors; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human