Citalopram treatment of minor depression in elderly men: an open pilot study.
Antidepressant pharmacotherapy in elderly patients is challenging. The authors examined the use of citalopram to treat late-life minor depression. Ten men (mean age: 73+/-2 years) with DSM-IV Minor Depression were administered citalopram 20 mg/day. Efficacy was measured with the Geriatric Depression Scale (GDS), the Montgomery-Asberg Depression Rating Scale (MADRS), and the Clinical Global Impressions of Severity (CGI-S) scales. Citalopram was well tolerated, and GDS, MADRS, and CGI-S scores decreased after 12 weeks. These findings indicate that citalopram is safe and effective in the treatment of late-life minor depression.
Kasckow
John W
JW
Department of Psychiatry, University of Cincinnati College of Medicine, and the Cincinnati VAMC, Cincinnati, OH 45267-0559, USA.
Welge
Jeff
J
Carroll
Brendan T
BT
Thalassinos
Arthur
A
Mohamed
Sonia
S
D000368:Aged; D000704:Analysis of Variance; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D015283:Citalopram / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009820:Ohio; D010044:Outpatient Clinics, Hospital; D010865:Pilot Projects; D011446:Prospective Studies
D018687:Antidepressive Agents, Second-Generation; D015283:Citalopram