A trypanocidal phenazine derived from beta-lapachone.
An intensive effort has been directed toward finding alternative drugs for treatment of Chagas' disease, caused by Trypanosoma cruzi, and prophylaxis of blood in endemic areas. Our research comprises the synthesis and trypanocidal screening of derivatives from naphthoquinones. Herein a new phenazine, obtained from the reaction of beta-lapachone with aniline, has its structure established by physical data and X-ray analysis. It was 9 times more active against T. cruzi trypomastigotes than crystal violet.
Neves-Pinto
Cleverson
C
Núcleo de Pesquisas em Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, 21944-970 Rio de Janeiro, RJ, Brazil.
Malta
Valéria R S
VR
Pinto
Maria do Carmo F R
Mdo C
Santos
Regina H A
RH
de Castro
Solange L
SL
Pinto
Antônio Ventura
AV
D000814:Aniline Compounds / Q000737:chemistry; D000818:Animals; D018360:Crystallography, X-Ray; D010619:Phenazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects*
C455283:7,8-dihydro-2,2-dimethyl-6-(N-phenyl)-3-(N-phenylamino)-4-(N-phenylimino)-4H,6H,7H-benzo(a)pyran(2,3-c)phenazine; D000814:Aniline Compounds; D010619:Phenazines; D014344:Trypanocidal Agents; C023650:aniline