title: Peculiar unilateral fixed drug eruption of the breast.
abstract: BACKGROUND
  Fixed drug eruption (FDE) is a common cutaneous disorder which develops within hours of taking the offending drug and recurs at the same site with subsequent exposure to the same drug. Non-steroidal anti-inflammatory drugs (NSAIDs) are common offending drugs.
  
  
  METHODS
  A 14-year-old girl initially presented with a 1-year history of a recurrent reddish-brown plaque around her right areola. The lesion became pruritic and raised during menses, and subsided during the remainder of her menstrual cycle with the exception of persistent residual hyperpigmentation. The patient had a pattern of naproxen use during menses for dysmenorrhea.
  
  
  RESULTS
  The skin biopsy specimen revealed focal bullae formation and scattered necrotic keratinocytes in epidermis, hydropic degeneration of the basal cell layer, pigmentary incontinence and a perivascular infiltrate composed of lymphocytes and eosinophils. These changes confirmed the diagnosis of fixed drug eruption.
  
  
  CONCLUSIONS
  Fixed drug eruption to nonsteroidal anti-inflammatory drugs is common. However, FDE due to naproxen, one of the NSAIDs, is rarely reported. We describe an unusual case of FDE, which recurred at each menses.
authors: Department of Dermatology, New Jersey Medical School, Newark, New Jersey 07103-2714, USA.
authors: Hong
authors: H
authors: Li
authors: Michael
authors: M
authors: Wiederkehr
authors: Babar k
authors: Bk
authors: Rao
authors: Joseph A
authors: JA
authors: Samady
authors: Bernard
authors: B
authors: Gardner
authors: W Clark
authors: WC
authors: Lambert
authors: Robert A
authors: RA
authors: Schwartz
mesh_terms: D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001941:Breast Diseases / Q000139:chemically induced* / Q000473:pathology*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D009288:Naproxen / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen