title: Role of oxidized low-density lipoprotein in renal disease.
abstract: Accelerated atherosclerosis is often observed in patients with chronic renal failure. In the present review we summarize and discuss the recent literature on the pathogenic role of low-density lipoproteins modified by oxidative processes in atherosclerosis and the possible role in renal diseases. Pathogenetically, the oxidation of low-density lipoproteins is considered to be a key event in the development of atherosclerosis, in part by causing enhanced uptake of lipids by macrophages. In addition, oxidation of low-density lipoproteins exerts cytotoxic, proinflammatory and immunogenic properties, all of which could potentially contribute to the development and progression of atherosclerosis.
authors: Department of Clinical and Experimental Immunology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands. p.heeringa@immuno.unimaas.nl
authors: Peter
authors: P
authors: Heeringa
authors: Jan W Cohen
authors: JW
authors: Tervaert
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000276:immunology; D008077:Lipoproteins, LDL / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D001323:Autoantibodies; D008077:Lipoproteins, LDL