title: Intravascular lymphomatosis.
abstract: Intravascular lymphomatosis, also known as endovascular lymphoma or angiotropic large cell lymphoma, is a rare malignancy typically diagnosed at autopsy. We describe a case in which the diagnosis was made at an early stage. Specific electrodiagnostic findings suggested concomitant polyneuropathy and myopathy. Suspicion of a paraneoplastic syndrome during electrodiagnostic testing prompted muscle biopsy, which revealed myopathy due to the direct infiltration of neoplastic cells. Resultant treatment with a standard chemotherapy regimen not only increased the patient's survival, but also improved neurological function.
authors: Department of Rehabilitation Medicine, University of Washington Medical Center, Seattle, Washington, USA.
authors: Melina E
authors: ME
authors: Oei
authors: Department of Rehabilitation Medicine, University of Washington Medical Center, Seattle, Washington, USA.
authors: George H
authors: GH
authors: Kraft
authors: Departments of Pathology (Neuropathology) and Pediatrics (Neurology), Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors: Harvey B
authors: HB
authors: Sarnat
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004317:Doxorubicin / Q000627:therapeutic use*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D009135:Muscular Diseases / Q000209:etiology / Q000473:pathology; D009361:Neoplasm Invasiveness; D011115:Polyneuropathies / Q000209:etiology; D011241:Prednisone / Q000627:therapeutic use*; D016896:Treatment Outcome; D019043:Vascular Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone