Theoretical analysis of mixed irradiation (3).
As the model we proposed last year was contradictory to experimental data, we revised again the models for mixed irradiation by Zaider and Rossi and by Suzuki, substituting a 'reciprocal-time' pattern of repair function for a first-order one in reduction and interaction factors of the models, although we used a second order repair function last year. The reduction factor, which reduces the contribution of the square of a dose to cell killing in the models, and the interaction factor, which also reduces the contribution of the interaction of two or more doses of different types of radiation, were formulated by using the 'reciprocal-time' pattern of repair function. These newly modified models for mixed irradiation could express or predict cell survival more accurately than the older ones, especially when irradiation is prolonged at low dose rates. We present survival curves of cells calculated from the newly and the older models of assumptive simultaneous mixed irradiation with two or three types of radiation.
Suzuki
S
S
Tokyo Metro. Inst. of Gerontol., Tokyo, Japan.
Miura
Y
Y
Mizuno
S
S
Furusawa
Y
Y
D000818:Animals; D002244:Carbon; D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured; D006224:Cricetinae; D004307:Dose-Response Relationship, Radiation; D008954:Models, Biological; D009356:Neon; D011853:Radiobiology; D016019:Survival Analysis; D014965:X-Rays
D009356:Neon; D002244:Carbon