Pathophysiology of infantile spasms.
Infantile spasms--seen in West's Syndrome--are often associated with cortical abnormalities. The spasms themselves, however, appear to be generated subcortically. Dr. Chugani reviews the clinical data related to the pathophysiology of infantile spasms and proposes a hypothesis which involves both cortical and subcortical mechanisms.
Chugani
Harry T
HT
Division of Pediatric Neurology and PET Center Children's Hospital of Michigan, Wayne State University, Detroit 48201, USA.
D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004594:Electrophysiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D018377:Neurotransmitter Agents / Q000502:physiology; D013036:Spasms, Infantile / Q000473:pathology / Q000503:physiopathology*
D018377:Neurotransmitter Agents