title: [A clinical analysis of patients with early-stage prostate cancer managed without initial treatment].
abstract: To search for a more suitable qualification indicating watchful waiting, we performed a retrospective study against early-stage prostate cancer patients managed without initial treatment. Thirty-three patients who had not been treated for more than 6 months after diagnosed as T1c or T2 prostate cancer were studied. The median values of total observation period, age at diagnosis, and initial PSA were 27.0 months, 69.0 years old, and 7.0 ng/ml, respectively. Among 28 patients who had had measurement of serum PSA at least three times, seven patients showed a significant PSA elevation when transition of PSA level was analyzed using linear regression analysis. The other patients had been stable or PSA level declined. Between these two groups, there was no significant difference regarding age, initial PSA, PSA density, Gleason score, number of cancer-positive core, and cancer-occupying rate in biopsy specimen. The median PSA doubling time in patients showing PSA elevation was 36.3 months. There were no patients showing PSA elevation among those with a cancer-occupying rate of less than 5%. Clinical disease progression was obviously observed in two cases although one did not show PSA elevation. During the observation period, treatment was eventually started in seven patients. The 5-year rate of no treatment was 53.8%. Although a significant independent factor predicting the future treatment was not identified, univariate analysis revealed that the initial PSA value in patients undergoing treatment was significantly higher than that of those without treatment (p = 0.032). We concluded that early-stage prostate cancer has clinical variability, and regular clinical evaluations as digital rectal examination should be performed when the patient was managed with watchful waiting.
authors: Kansai Medical University, Prostate Study Group.
authors: Gen
authors: G
authors: Kawa
authors: Yoshihito
authors: Y
authors: Hiura
authors: Hisashi
authors: H
authors: Satoh
authors: Motohiko
authors: M
authors: Sugi
authors: Ichiro
authors: I
authors: Fujita
authors: Naoki
authors: N
authors: Oguchi
authors: Hiroshi
authors: H
authors: Doi
authors: Makoto
authors: M
authors: Ashida
authors: Hiyoshi
authors: H
authors: Okada
authors: Koei
authors: K
authors: Muguruma
authors: Takashi
authors: T
authors: Murota
authors: Yasuki
authors: Y
authors: Koyama
authors: Hiroshi
authors: H
authors: Kawamura
authors: Takashi
authors: T
authors: Ohara
authors: Mutsushi
authors: M
authors: Kawakita
authors: Tadashi
authors: T
authors: Matsuda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D017430:Prostate-Specific Antigen