Vitamin D receptor start codon polymorphism (Fok I) and bone mineral density in Chinese men and women.
The relationship between Fok I polymorphism of the vitamin D receptor start codon, bone mineral density (BMD) and vertebral fractures was studied in 684 Chinese men and women. A significant trend was observed only in Chinese women aged 70-79 years. The mean BMD at the total body was 0.85 +/- 0.01 g/cm2, 0.82 +/- 0.01 g/cm2 and 0.84 +/- 0.01 g/cm2 for elderly women of the FF, Ff and ff genotypes respectively (p = 0.06 by ANOVA). Similar but statistically non-significant trends were observed at the hip and spine. However, no association between BMD and the Fok I genotype was observed in younger women (aged 50-59 years) and elderly men (aged 70-79 years). In all study groups, there was no effect of an interaction between Fok I polymorphism and calcium intake on BMD (p > 0.05 for the interaction effects by two-way ANOVA). No significant association was observed between Fok I polymorphism and vertebral fracture in elderly men or women (p > 0.05 by the chi-square test). We conclude that the Fok I polymorphism may have a weak effect on the BMD of elderly Chinese women.
Lau
E M C
EM
Department of Family and Community Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin. edithlau@cuhk.edu.hk
Lam
V
V
Li
M
M
Ho
K
K
Woo
J
J
D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D015519:Bone Density / Q000235:genetics*; D002681:China; D018387:Codon, Initiator / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D012737:Sex Factors; D016103:Spinal Fractures / Q000235:genetics*
D018387:Codon, Initiator; D018167:Receptors, Calcitriol