title: A newly identified single nucleotide polymorphism in the promoter of the matrix metalloproteinase-1 gene.
abstract: Matrix metalloproteinase-1 (MMP-1) is a member of the matrix metalloproteinase enzyme family that degrades components of the extracellular matrix. Recent studies have demonstrated several polymorphic sites in the promoter of the MMP-1 gene. A newly identified single nucleotide polymorphism (SNP) at position -519 in the promoter region of the MMP-1 gene is reported. This polymorphism consists in a guanine to adenine substitution. A linkage between polymorphisms -519A/G and -1607 1G/2G was also studied.
authors: Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. mjuraj@med.muni.cz
authors: M
authors: M
authors: Jurajda
authors: J
authors: J
authors: Muzík
authors: L
authors: L
authors: Izakovicová Hollá
authors: J
authors: J
authors: Vácha
mesh_terms: D000328:Adult; D000368:Aged; D001665:Binding Sites; D015179:Colorectal Neoplasms / Q000235:genetics; D018153:Czech Republic; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D044465:White People
chemical_list: D020781:Matrix Metalloproteinase 1