title: Nitric oxide in the penumbra of a focal cortical necrosis in rats.
abstract: After a focal cortical freezing lesion in rats, nitric oxide (NO) end products were studied with microdialysis in the extracellular space of the penumbra throughout the whole period of secondary expansion of the cortical necrosis (i.e. 24 h). Under baseline conditions, the dialysate concentration of nitrate (nitrite) was 1.8 +/- 0.78 microM (5.00 +/- 1.50 microM) in the sham-operated group and 2.28 +/- 0.62 microM (3.25 +/- 1.32 microM) in the trauma group. In animals of both groups, these parameters neither showed significant alterations within the observation period compared with baseline values nor between the groups at each individual study time point. After focal cortical trauma, NO does not mediate secondary necrosis expansion via the extracellular space.
authors: Department of Neurosurgery, Rheinische Friedrich-Wilhelms-University, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. michael.stoffel@ukb.uni-bonn.de
authors: Michael
authors: M
authors: Stoffel
authors: Markus
authors: M
authors: Rinecker
authors: Rudolf
authors: R
authors: Graf
authors: Alexander
authors: A
authors: Baethmann
authors: Nikolaus
authors: N
authors: Plesnila
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000293:injuries* / Q000378:metabolism* / Q000503:physiopathology; D003080:Cold Temperature / Q000009:adverse effects; D005110:Extracellular Space / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D009336:Necrosis; D009410:Nerve Degeneration / Q000378:metabolism* / Q000503:physiopathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D009566:Nitrates / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide