Opposite effects of olanzapine and haloperidol in rat ultrasonic vocalization test.
The opposite effects of the classical antipsychotic, haloperidol, and atypical neuroleptic, olanzapine, in the rat ultrasonic vocalization test of anxiety were observed. The present data are discussed in relation to growing body of evidence of specific brain biochemical changes after pretreatment with different antipsychotics.
Siemiatkowski
M
M
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
Maciejak
P
P
Sienkiewicz-Jarosz
H
H
Członkowska
A I
AI
Szyndler
J
J
Gryczyńska
A
A
Płaźnik
A
A
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001007:Anxiety / Q000209:etiology / Q000523:psychology; D001569:Benzodiazepines; D006220:Haloperidol / Q000494:pharmacology*; D008024:Ligands; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000378:metabolism; D014465:Ultrasonics / Q000009:adverse effects; D014828:Vocalization, Animal / Q000187:drug effects*
D014150:Antipsychotic Agents; D008024:Ligands; D011954:Receptors, Dopamine; D001569:Benzodiazepines; D010890:Pirenzepine; D006220:Haloperidol; D000077152:Olanzapine