Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin after coronary stent implantation: 1 and 6-month follow-up.
BACKGROUND
Clopidogrel is a new thienopyridine derivative and has less serious hematologic complications. We investigated the efficacy of clopidogrel plus aspirin (CA) in stent thrombosis prevention compared with ticlopidine plus aspirin (TA).


RESULTS
Sixty-eight patients who underwent coronary stenting were randomized into 2 groups: TA group, n = 31 and CA group, n = 37. At 1 month, there were 3 major bleeding complications, 2 in the CA group and 1 in the TA group. Neither stent thrombosis nor hematologic events were found in both groups. Two patients in the TA group died, 1 from sudden death and another from tracheal stenosis. At 6 months, five patients developed in-stent restenosis, 4 in the CA group and 1 in the TA group, p = NS. One patient in each group had acute coronary syndrome.


CONCLUSIONS
Clopidogrel plus aspirin is an effective coronary stenting regimen comparable to ticlopidine plus aspirin.
Piamsomboon
C
C
Department of Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand.
Laothavorn
P
P
Chatlaong
B
B
Saguanwong
S
S
Nasawadi
C
C
Tanprasert
P
P
Leelaprute
M
M
Intayakorn
U
U
Amornsak
N
N
D000368:Aged; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D019917:Blood Vessel Prosthesis Implantation; D000077144:Clopidogrel; D023921:Coronary Stenosis / Q000601:surgery*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D015607:Stents; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D013997:Time Factors
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin