Intracerebroventricular injection of glucagon-like peptide-1 decreases monoamine concentrations in the hypothalamus of chicks.
1. We measured the concentrations of dopamine (DA), norepinephrine (NE), epinephrine (E) and 5-hydroxytryptamine (5-HT) in the hypothalamus of 21-d-old male brown-egg layer-type chicks after intracerebroventricular injection of glucagon-like peptide-1 (GLP-1). 2. The monoamine concentrations of the whole hypothalamus, paraventricular nucleus and lateral hypothalamic area were not significantly affected by GLP-1. 3. However, concentrations of DA, NE and E, but not 5-HT, in the ventromedial hypothalamic nucleus (VMH) were significantly decreased by GLP-1. 4. These observations suggest that the anorexigenic effect of GLP-1 involves catecholaminergic systems in the VMH in the chick.
Tachibana
T
T
United Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Japan.
Tanaka
S
S
Furuse
M
M
Hasegawa
S
S
Kato
H
H
Sugahara
K
K
D000818:Animals; D002645:Chickens / Q000378:metabolism*; D004298:Dopamine / Q000096:biosynthesis*; D004837:Epinephrine / Q000096:biosynthesis*; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology*; D052216:Glucagon-Like Peptide 1; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000096:biosynthesis*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011498:Protein Precursors / Q000008:administration & dosage / Q000494:pharmacology*; D012701:Serotonin / Q000096:biosynthesis*
D010446:Peptide Fragments; D011498:Protein Precursors; D012701:Serotonin; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine