Landing of immune receptors and signal proteins on lipid rafts: a safe way to be spatio-temporally coordinated?
In the past decade one of the cell biology's breakthroughs was discovery of membrane microdomains (rafts, caveolae) and recognition of their important in cellular signaling and protein traffic. In the present minireview a short comprehensive overview is given about physico-chemical, structural and functional properties of rafts. In addition to the classical immunochemical techniques the latest physcial and biophysical technologies that can be used to study these microdomains are also described briefly. The funcational significance of rafts in signaling of multichain immune recognition receptors (MIRRs), the IL-2R and ErbB family factor receptors is also discussed herein together with the still open questions and future prospects of the raft hypothesis.
Matkó
János
J
Department of Immunology, Eotvos Lorand University, Budapest, Hungary. matko@cerberus.elte.hu
Szöllõsi
János
J
D000818:Animals; D066246:ErbB Receptors / Q000378:metabolism; D007700:Kinetics; D008214:Lymphocytes / Q000276:immunology; D021962:Membrane Microdomains / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism*; D018625:Microscopy, Atomic Force; D008856:Microscopy, Fluorescence; D018448:Models, Immunological; D021381:Protein Transport; D011971:Receptors, Immunologic / Q000378:metabolism*; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D015398:Signal Transduction
D008565:Membrane Proteins; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D066246:ErbB Receptors