title: Kinetic resolutions of indan derivatives using bacteria.
abstract: Racemic indan derivatives have been resolved by the hydrolysis of amide bonds using Corynebacterium ammoniagenes IFO12612 to produce (S)-amine and (R)-amides. In the kinetic resolution of 1 (N-12-(6-methoxy-indan-1-yl)ethyl]acetamide), it was possible to run the reaction to 44% conversion on a 10-g scale, obtaining (S)-amine 4 ((S)-2-(6-methoxy-indan-1-yl)ethylamine) at >99% enantiomeric excess (ee) and (R)-1 at 98% ee.
authors: Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan. Tarui_Naoki@takeda.co.jp
authors: Naoki
authors: N
authors: Tarui
authors: Hayao
authors: H
authors: Watanabe
authors: Kohji
authors: K
authors: Fukatsu
authors: Shigenori
authors: S
authors: Ohkawa
authors: Kazuo
authors: K
authors: Nakahama
mesh_terms: D003352:Corynebacterium / Q000378:metabolism*; D006868:Hydrolysis; D007189:Indans / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D007700:Kinetics
chemical_list: D007189:Indans; C093582:indan