title: Celsior solution provides superior post-ischemic right ventricular function as compared with UW solution in a porcine heart transplantation model.
abstract: BACKGROUND
  Use of the new cardioprotective Celsior solution has been suggested for organ preservation in cardiac transplantation, but selective data for right ventricular function, of special interest in the clinical setting, have not been evaluated.
  
  
  METHODS
  Celsior solution was compared with the clinical standard University of Wisconsin solution (UW) in a porcine allogenic heart transplantation model with accurate isovolumic measurement of right ventricular (RV) function.
  
  
  RESULTS
  Maximum RV developed pressures were significantly different between Celsior and UW groups (51.1 +/- 9.6 mm Hg vs 42.2 +/- 15.4 mm Hg after 1 hour, respectively, and 55.6 +/- 7.8 mm Hg vs 45.1 +/- 16.2 mm Hg after 2 hours, respectively; p = 0.02, 2-way analysis of variance).
  
  
  CONCLUSIONS
  Celsior significantly improves post-ischemic right ventricular function when compared with UW solution in an experimental heart transplantation model.
authors: Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany.
authors: Gregor
authors: G
authors: Warnecke
authors: Benjamin
authors: B
authors: Schulze
authors: Axel
authors: A
authors: Haverich
authors: Uwe
authors: U
authors: Klima
mesh_terms: D000241:Adenosine / Q000008:administration & dosage*; D000493:Allopurinol / Q000008:administration & dosage*; D000818:Animals; D004187:Disaccharides / Q000008:administration & dosage*; D004573:Electrolytes / Q000008:administration & dosage*; D005971:Glutamates / Q000008:administration & dosage*; D005978:Glutathione / Q000008:administration & dosage*; D016027:Heart Transplantation / Q000502:physiology*; D006639:Histidine / Q000008:administration & dosage*; D007328:Insulin / Q000008:administration & dosage*; D008353:Mannitol / Q000008:administration & dosage*; D023421:Models, Animal; D019188:Organ Preservation Solutions; D011887:Raffinose / Q000008:administration & dosage*; D013552:Swine; D016278:Ventricular Function, Right / Q000502:physiology*
chemical_list: C088453:Celsior; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D008353:Mannitol; D006639:Histidine; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose