title: Mycophenolate mofetil: selective T cell inhibition.
abstract: Mycphenolate mofetil is a suppressor of T cell proliferation and adhesion. Its primary mode of action is inhibition of inosine monophosphate dehydrogenase, a purine salvage pathway required by T lymphocytes. Although the role of T cells in rheumatoid arthritis (RA) has been controversial, a preliminary report of mycophenolate mofetil's successful use in RA patients clearly suggests that its efficacious properties need further investigation. Its favorable risk/benefit ratio, a broad clinical experience in kidney transplantation, and its recent extension to other rheumatic diseases suggests that this new antirheumatic agent has significant therapeutic potential for suppression of synovial inflammation.
authors: Rheumatology Section, Medical Service, G.V (Sonny) Montgomery VA Medical Center, Jackson, Mississippi 39216, USA. robert.mcmurray@med.va.gov
authors: Robert W
authors: RW
authors: McMurray
authors: Valee
authors: V
authors: Harisdangkul
mesh_terms: D002448:Cell Adhesion; D002455:Cell Division; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000187:drug effects*
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid