title: A potent polymer/pyridoxamine enzyme mimic.
abstract: An enzyme mimic consisting of pyridoxamines covalently linked to polyethyleneimine carrying long-chain alkyl groups converts pyruvic acid to dl-alanine with as much as an 8000-fold acceleration relative to the reaction with simple pyridoxamine at the same pyridoxamine concentration. The acceleration by polymer is a strong function of the length of the alkyl chains that are appended. The polymer furnishes acid and base groups to catalyze the proton transfers that are involved in transamination.
authors: Department of Chemistry, Columbia University, New York, New York 10027, USA.
authors: Lei
authors: L
authors: Liu
authors: Ronald
authors: R
authors: Breslow
mesh_terms: D007700:Kinetics; D018716:Molecular Mimicry; D011094:Polyethyleneimine / Q000737:chemistry* / Q000378:metabolism; D011733:Pyridoxamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship; D000637:Transaminases / Q000737:chemistry* / Q000378:metabolism
chemical_list: D011733:Pyridoxamine; D011094:Polyethyleneimine; D000637:Transaminases