title: Structure and biosynthesis of human salivary mucins.
abstract: Human salivary glands secrete two types of mucins: oligomeric mucin (MG1) with molecular mass above 1 MDa and monomeric mucin (MG2) with molecular mass of 200-250 kDa. Monomers of MG1 and MG2 contain heavily O-glycosylated tandem repeats located at the central domain of the molecules. MG1 monomers are linked by disulfide bonds located at sparsely glycosylated N- and C-end. MG1 are synthesized by mucous cells and MG2 by the serous cells of human salivary glands.
authors: Department of Pharmaceutical Biochemistry Institute of Chemistry, Białystok, Poland. kzwie@amb.ac.bialystok.pl
authors: A
authors: A
authors: Zalewska
authors: K
authors: K
authors: Zwierz
authors: K
authors: K
authors: Zółkowski
authors: A
authors: A
authors: Gindzieński
mesh_terms: D000595:Amino Acid Sequence; D002240:Carbohydrate Sequence; D006031:Glycosylation; D006801:Humans; D008969:Molecular Sequence Data; D055257:Mucin-5B; D009077:Mucins / Q000096:biosynthesis / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D017434:Protein Structure, Tertiary; D012463:Saliva / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000096:biosynthesis / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
chemical_list: C524578:MUC5B protein, human; C083238:MUC7 protein, human; D055257:Mucin-5B; D009077:Mucins; D009844:Oligosaccharides; D010455:Peptides; D012471:Salivary Proteins and Peptides