Genomic organization of the interleukin-1 locus.
Recent additions have expanded the interleukin (IL)-1 gene family to 10 members. We have determined the order, orientation, and intergenic distance of the nine IL-1 family genes that lie on human chromosome 2. We report cDNA sequences for the mouse orthologs of three of these genes. The order and orientation of the mouse genes have been mapped, and the mouse locus compared with the human locus. There is a break in the mouse locus of > 100 kb, compared with the human locus, located between Il1b and the most centromere-proximal of the novel mouse genes. The mouse seems to be missing an ortholog of human IL1F7.
Taylor
Scott L
SL
Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA.
Renshaw
Blair R
BR
Garka
Kirsten E
KE
Smith
Dirk E
DE
Sims
John E
JE
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics; D005091:Exons; D023061:Gene Order; D005796:Genes / Q000235:genetics; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D026801:Synteny
D018076:DNA, Complementary; D007375:Interleukin-1