title: Local photodynamic therapy reduces tissue hyperplasia after stenting in an experimental restenosis model.
abstract: Local photodynamic therapy was used to prevent neointimal hyperplasia after stenting. Slotted tube stents were placed with 16 atmospheres in porcine femoral arteries with the external diameter to match the diameter at 10 atmospheres. Animals were randomly allocated to Group 1 (stenting only); or Group 2 with stenting, local drug delivery of a photosensitizer (5 mg Photofrin) and subsequent exposure to light (photodynamic therapy, 100 J). Fourteen days later, all vessels were excised, fixed and processed for histology. Tissue hyperplasia was observed after stenting in vessels from Group 1. In Group 2 with photodynamic therapy, the myoproliferative response was significantly reduced. Tissue hyperplasia after stenting was effectively suppressed by photodynamic therapy.
authors: Institute of Anatomy, University Munich, Germany.
authors: Grigorios
authors: G
authors: Valassis
authors: Ingo
authors: I
authors: Pragst
authors: Christian
authors: C
authors: Adolfs
authors: Daniela
authors: D
authors: Paclik
authors: Franziska
authors: F
authors: Wiens
authors: Claudia
authors: C
authors: Vogel-Wiens
authors: Stefan
authors: S
authors: Milz
authors: Peter
authors: P
authors: Gonschior
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003131:Combined Modality Therapy; D003327:Coronary Disease / Q000188:drug therapy / Q000473:pathology; D023903:Coronary Restenosis / Q000188:drug therapy* / Q000473:pathology; D017323:Dihematoporphyrin Ether / Q000494:pharmacology*; D005263:Femoral Artery / Q000473:pathology; D006965:Hyperplasia; D010778:Photochemotherapy; D015607:Stents; D013552:Swine
chemical_list: D000970:Antineoplastic Agents; D017323:Dihematoporphyrin Ether