Magnesium bioavailability from mineral water. A study in adult men.
OBJECTIVE
To assess magnesium enteral absorption from a magnesium-rich mineral water.


METHODS
Experimental study.


METHODS
Department of Nuclear Medicine, Brugmann Hospital, Brussels, Belgium.


METHODS
Ten healthy male volunteers in the age range 25-42 y.


METHODS
Each subject completed two sessions in a random order. At one session, they received an oral load of 300 ml of water (containing 1.2 mmol Mg), traced with (28)Mg, and at the other session they received an intravenous injection of (28)Mg, in order to take into account the metabolism of endogenous magnesium. The dietary consumption was further noted on a weekly diary.


RESULTS
The mean bioavailability was 59.1% (s.d.+/-13.6). Magnesium absorption and age were significantly inversely correlated (r=-0.68, P=0.035).


CONCLUSIONS
Magnesium-rich mineral water is a reliable source of magnesium. Our observation of decreased magnesium absorption with age deserves further investigations.


BACKGROUND
The study was sponsored by SEV, Bourg la Reine, France.
Verhas
M
M
Department of Nuclear Medicine, CHU Brugmann-Free University of Brussels, Brussels, Belgium. mverhas@pop.vub.ac.be
de la Guéronnière
V
V
Grognet
J-M
JM
Paternot
J
J
Hermanne
A
A
Van den Winkel
P
P
Gheldof
R
R
Martin
P
P
Fantino
M
M
Rayssiguier
Y
Y
D000284:Administration, Oral; D000328:Adult; D000367:Age Factors; D001682:Biological Availability; D006801:Humans; D007275:Injections, Intravenous; D007408:Intestinal Absorption / Q000502:physiology*; D007553:Isotope Labeling; D008274:Magnesium / Q000493:pharmacokinetics*; D008297:Male; D008900:Mineral Waters / Q000032:analysis*
D008900:Mineral Waters; D008274:Magnesium