Reevaluation of the role of HWP1 in systemic candidiasis by use of Candida albicans strains with selectable marker URA3 targeted to the ENO1 locus.
Previous evaluation of HWP1 in systemic candidiasis in CBA/J mice was done with Candida albicans strains with differing genetic locations of URA3 as a result of Ura-blaster mutagenesis. In this study, the presence of HWP1 and the location of URA3 contributed to the severity of murine systemic candidiasis in BALB/c mice.
Sundstrom
Paula
P
Department of Molecular Virology, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA. sundstrom.1@osu.edu
Cutler
Jim E
JE
Staab
Janet F
JF
D000818:Animals; D015415:Biomarkers; D002176:Candida albicans / Q000235:genetics / Q000472:pathogenicity; D002177:Candidiasis / Q000382:microbiology* / Q000401:mortality / Q000503:physiopathology; D004195:Disease Models, Animal; D005656:Fungal Proteins / Q000235:genetics*; D005800:Genes, Fungal; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010751:Phosphopyruvate Hydratase / Q000235:genetics*
D015415:Biomarkers; D005656:Fungal Proteins; C118102:HWP1 protein, Candida albicans; D008562:Membrane Glycoproteins; C457379:Eno1 protein, mouse; D010751:Phosphopyruvate Hydratase