Further studies on the interaction of Toxoplasma gondii with neutrophils and eosinophils.
Tachyzoites of Toxoplasma gondii are ingested by neutrophils and eosinophils through a process which can be significantly inhibited by previous incubation of the host cells with cytochalasin D. Although dividing zoites within the leukocytes could be observed, after 3 h of infection, killing of parasites within the parasitophorous vacuole was detected. Cytochemical studies showed that both in neutrophils and eosinophils there is a process of NADP(H) oxidase activation, which was higher in the latter.
MacLaren
A
A
Laboratory of Cellular Ultrastructure Hertha Meyer, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Brazil.
De Souza
W
W
D000818:Animals; D002478:Cells, Cultured; D015638:Cytochalasin D / Q000494:pharmacology; D004804:Eosinophils / Q000187:drug effects / Q000201:enzymology / Q000469:parasitology* / Q000648:ultrastructure*; D006790:Host-Parasite Interactions; D051379:Mice; D019255:NADPH Oxidases / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology / Q000469:parasitology* / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D014122:Toxoplasma / Q000187:drug effects / Q000472:pathogenicity* / Q000648:ultrastructure*
D015638:Cytochalasin D; D019255:NADPH Oxidases