title: The influence of body mass index on skin susceptibility to sodium lauryl sulphate.
abstract: BACKGROUND
  The influence of nutrition on the physiological functions of man is well studied. Numerous diseases can be exacerbated by obesity. However, it has not yet been determined whether body weight and body mass index (BMI), as an indicator of a high body fat store, can influence skin sensitivity.
  
  
  OBJECTIVE
  This study investigates the correlation between body mass index and the epidermal functions, evaluated by bioengineering methods, before and after an irritant patch test with sodium lauryl sulphate (SLS).
  
  
  METHODS
  Epidermal functions were evaluated using an evaporimeter, chromameter and laser-Doppler-flowmeter. Patch testing was conducted for 48 h with two different concentrations of SLS (0.25% and 0.5%) on the forearms of healthy volunteers. Measurements were performed 24h after patch removal.
  
  
  RESULTS
  Obese individuals showed significantly increased transepidermal water loss (TEWL), skin blood flow and skin colour (red) as compared to a control group. However, the degree of skin sensitivity to SLS was not correlated with BMI.
  
  
  CONCLUSIONS
  Basal biophysical parameters of the skin are primarily correlated with the BMI. This may be caused by obesity-induced physiological changes, e.g. increased sweat gland activity, high blood pressure and physiological temperature-regulating system. The epidermal barrier function, as evaluated after SLS patch testing is, however, not correlated with a high BMI, indicating a normal skin barrier.
authors: Department of Dermatology, University of Marburg, Germany. Harald.Loeffler@mailer.uni-marburg.de
authors: H
authors: H
authors: Löffler
authors: J U N
authors: JU
authors: Aramaki
authors: Isaak
authors: I
authors: Effendy
mesh_terms: D000293:Adolescent; D000328:Adult; D055592:Biophysical Phenomena; D001703:Biophysics; D015992:Body Mass Index; D017453:Dermatitis, Irritant / Q000175:diagnosis / Q000378:metabolism*; D004817:Epidermis / Q000187:drug effects*; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism; D012867:Skin / Q000098:blood supply / Q000187:drug effects; D023422:Skin Irritancy Tests; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects*; D013501:Surface-Active Agents / Q000009:adverse effects*; D014867:Water / Q000378:metabolism
chemical_list: D013501:Surface-Active Agents; D014867:Water; D012967:Sodium Dodecyl Sulfate