A randomized controlled trial of azithromycin versus doxycycline/ciprofloxacin for the syndromic management of sexually transmitted infections in a resource-poor setting.
A randomized controlled trial was carried out to assess the effectiveness of azithromycin versus a standard regimen with doxycycline/ciprofloxacin in the treatment of sexually transmitted infections in a resource-poor environment. Infection with Chlamydia trachomatis was cured in 23/24 (95.8%) of women in the azithromycin arm versus 19/21 (90.5%) in the doxycycline arm (P = 0.6), resulting in three treatment failures. Gonorrhoea was cured in 55/56 (98.2%) women, with one treatment failure in a patient with concomitant C. trachomatis infection. These results indicate that a single oral dose of azithromycin may prove to be a more effective and convenient treatment for sexually transmitted infections in women in a resource-poor environment
Rustomjee
Roxana
R
Unit for Clinical and Biomedical Tuberculosis Research, Medical Research Council, King George V Hospital, PO Box 19494, Domerton 4015, South Africa. roxana.rustomjee@mrc.ac.za
Kharsany
A B M
AB
Connolly
C A
CA
Karim
S S Abdool
SS
D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D017963:Azithromycin / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy; D002939:Ciprofloxacin / Q000191:economics / Q000627:therapeutic use*; D004318:Doxycycline / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006069:Gonorrhea / Q000188:drug therapy; D006295:Health Resources; D006801:Humans; D015231:Sexually Transmitted Diseases, Bacterial / Q000188:drug therapy* / Q000191:economics / Q000382:microbiology; D013019:South Africa; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D017963:Azithromycin; D004318:Doxycycline