title: Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group.
abstract: Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with the 1,4-phenylene group yielded the promising HDAC inhibitors which possess a terminal bicyclic aryl amide.
authors: Department of Biotechnology, Faculty of Engineering, Kansai University, Suita, 564-8680, Osaka, Japan. uesato@ipicku.kansai-u.ac.jp
authors: Shinichi
authors: S
authors: Uesato
authors: Manabu
authors: M
authors: Kitagawa
authors: Yasuo
authors: Y
authors: Nagaoka
authors: Taishi
authors: T
authors: Maeda
authors: Hiroshi
authors: H
authors: Kuwajima
authors: Takao
authors: T
authors: Yamori
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D003110:Colonic Neoplasms; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000577:Amides; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors