title: Growth of human glioblastomas as xenografts in the brains of athymic rats.
abstract: BACKGROUND
  We have developed xenografts of human glioblastoma (GBM) and established the baseline growth parameters and histopathological features of these tumors.
  
  
  METHODS
  Cells from 4 different human GBM cell lines were injected into the right caudate-putamen of brain in athymic rats. We measured tumor weights and the estimated survival time of each rat. RESULTS-CONCLUSION: U-251 MG and U-87 MG cells produced solid intracerebral tumors with a 100% tumor take rate, while SF-767 and SF-126 cells did not grow in the brains of athymic rats. Under the conditions employed, U-87 MG tumors grew faster than U-251 MG tumors, but both types of tumors exhibited reproducible growth characteristics from animal to animal. There was heterogeneity in the growth characteristics and histologies between the 2 tumor types, indicating that these tumor models might be useful for simulating some of the heterogeneity that occurs between GBM in humans.
authors: Brain Tumor Research Center, Department of Neurological Surgery, School of Medicine, University of California, San Francisco, California 94143-0520, USA.
authors: Tomoko
authors: T
authors: Ozawa
authors: Jingli
authors: J
authors: Wang
authors: Lily J
authors: LJ
authors: Hu
authors: Andrew W
authors: AW
authors: Bollen
authors: Kathleen R
authors: KR
authors: Lamborn
authors: Dennis F
authors: DF
authors: Deen
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology*; D004195:Disease Models, Animal; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D008136:Longevity; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology*; D051381:Rats; D011923:Rats, Nude; D013997:Time Factors; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays / Q000379:methods*