The mitochondrial antioxidant defence system and its response to oxidative stress.
The antioxidant systems of mitochondria are not well known. Using a proteomics-based approach, we defined these mitochondrial antioxidant systems and analyzed their response to oxidative stress. It appears that the major mitochondrial antioxidant system is made of manganese superoxide dismutase on the one hand, and of peroxiredoxin III, mitochondrial thioredoxin and mitochondrial thioredoxin reductase on the other hand. With the exception of thioredoxin reductase, all these proteins are induced by oxidative stress. In addition, a change in the peroxiredoxin III pattern can also be observed.
Rabilloud
T
T
CEA-Laboratoire de Bioénergétique Cellulaire et Pathologique, DBMS/BECP, CEA-Grenoble, France. Thierry@sanrafael.ceng.cea.fr
Heller
M
M
Rigobello
M P
MP
Bindoli
A
A
Aebersold
R
R
Lunardi
J
J
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D006801:Humans; D019169:Jurkat Cells; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D018384:Oxidative Stress; D051381:Rats; D013880:Thioredoxin-Disulfide Reductase / Q000737:chemistry / Q000378:metabolism
D000975:Antioxidants; D013880:Thioredoxin-Disulfide Reductase