[A simple method for determination of flurbiprofen in human plasma by gas chromatography-mass spectrometry].
A method for gas chromatograph-mass spectrometric assay has been developed for the quantitation of flurbiprofen in human plasma. Extraction or condensing procedure was not required and the method reduced time involved in sample preparation. The analytes were separated on the fused-silica capillary column. The operating conditions were: injector, 250 degrees C; detector, 300 degrees C; and column, 50-280 degrees C. The total gas flow-rate of helium (carrier) was 50 ml.min-1 and the pressure of column inlet was 100-200 kPa. The retention time was 18.1 min and the limit of quantitation was 0.5 microgram.ml-1. This method provides an easy and simple method for the detection of flurbiprofen.
Satomoto
Maiko
M
Medical Corps, 1st Wings, Japan Air Self Defense Force, Hamamatsu 432-8551.
Adachi
Yushi
Y
Higuchi
Hideyuki
H
Watanabe
Kazuhiko
K
Satoh
Tetsuo
T
D005480:Flurbiprofen / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans
D005480:Flurbiprofen