title: Diacylglycerol kinases: emerging downstream regulators in cell signaling systems.
abstract: Diacylglycerol kinase (DGK) regulates signal transduction by modulating the balance between the two signaling lipids, diacylglycerol and phosphatidic acid. DGK and its homologs occur in a wide range of multicellular organisms and the mammalian DGK is known to consist of nine members with a considerable incidence of alternative splicing. Recent work has established that DGK serves as a key attenuator of diacylglycerol of signaling functions and that the mammalian isozymes are equipped with molecular machineries which enable them to act in specific intracellular sites and/or in signaling protein complexes.
authors: Department of Biochemistry, School of Medicine, Sapporo Medical University, South-West-17, Sapporo 060-8556, Japan. kanoh@sapmed.ac.jp
authors: Hideo
authors: H
authors: Kanoh
authors: Keiko
authors: K
authors: Yamada
authors: Fumio
authors: F
authors: Sakane
mesh_terms: D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D017124:Conserved Sequence; D019852:Diacylglycerol Kinase / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004075:Diglycerides / Q000378:metabolism; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D010712:Phosphatidic Acids / Q000378:metabolism; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism; D011955:Receptors, Drug / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014443:Tyrosine / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D004075:Diglycerides; D007527:Isoenzymes; D010712:Phosphatidic Acids; D011955:Receptors, Drug; C083141:phorbol ester binding protein; C027776:phorbol ester receptor; D014443:Tyrosine; D019852:Diacylglycerol Kinase; D011493:Protein Kinase C