Antibacterial diterpenoids from Fabiana densa var. ramulosa.
A biologically monitored fractionation of the resinous exudate of Fabiana densa Remy var. ramulosa Wedd. led to the isolation of the two new diterpenes: ent-beyer-15-en-18-O-succinate and ent-beyer-15-en-18-O-oxalate as the unique compounds responsible for the observed antibacterial activity of this extract. Their structures were determined by 1D and 2D NMR spectroscopy.
Erazo
Silvia
S
Zaldívar
Mercedes
M
Delporte
Carla
C
Backhouse
Nadine
N
Tapia
Paola
P
Belmonte
Eliana
E
Delle Monarche
Franco
F
Negrete
Rosa
R
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010070:Oxalates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D019657:Solanaceae; D013386:Succinates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010070:Oxalates; D010936:Plant Extracts; D013386:Succinates; C459630:ent-beyer-15-en-18-O-oxalate; C459629:ent-beyer-15-en-18-O-succinate