title: Coding single nucleotide polymorphism in the high-affinity immunoglobulin E receptor b chain (FcepsilonRI-beta) gene is associated with immunoglobulin E receptor-mediated histamine release from basophils.
abstract: BACKGROUND
  Our previous work on linkage analysis showed that histamine release from basophils to anti-IgE stimuli was linked to the gene marker of chromosome 11q13, where the beta chain of the high-affinity receptor for IgE (FcepsilonRI-beta) is located.
  
  
  OBJECTIVE
  To evaluate the association between FcepsilonRI-mediated histamine release from basophils and four bi-allelic single nucleotide polymorphisms of the FcepsilonRI-beta gene.
  
  
  METHODS
  Phenotypes of asthma, such as maximal histamine release from basophils and atopy, were measured from 80 randomly recruited asthmatic children. Polymorphisms of the FcepsilonRI-beta gene were determined by PCR-based methods.
  
  
  RESULTS
  The polymorphism in exon 7, resulting in Glu to Gly substitution, was significantly associated with histamine release from basophils to anti-IgE stimuli, but not with total IgE levels and skin test responses to aeroallergens.
  
  
  CONCLUSIONS
  This study supports a role for the FcepsilonRI-beta gene in the expression of high affinity IgE receptor-mediated histamine release from basophils.
authors: Department of Internal Medicine, Seoul National University College of Medicine, Korea. youyoung@plaza.snu.ac.kr
authors: Y-K
authors: YK
authors: Kim
authors: S-Y
authors: SY
authors: Oh
authors: H-B
authors: HB
authors: Oh
authors: S-Y
authors: SY
authors: Chun
authors: S-H
authors: SH
authors: Cho
authors: Y-Y
authors: YY
authors: Koh
authors: K-U
authors: KU
authors: Min
authors: Y-Y
authors: YY
authors: Kim
mesh_terms: D000293:Adolescent; D000483:Alleles; D001249:Asthma / Q000235:genetics*; D001491:Basophils / Q000276:immunology* / Q000378:metabolism; D000001:Calcimycin / Q000494:pharmacology; D002648:Child; D005260:Female; D006636:Histamine Release / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011897:Random Allocation; D017455:Receptors, IgE / Q000235:genetics* / Q000502:physiology*
chemical_list: D017455:Receptors, IgE; D000001:Calcimycin