Statistical analysis of the relationship between translation initiation AUG context and gene expression level in humans.
The preference for the optimal nucleotide of the mammalian translation initiation AUG context [GCCGCC(A/G)CCaugG] is generally more pronounced in the highly expressed genes than in the transcription factor genes at the -9 through -1 positions in humans. The influence of amino acid preference on the nucleotide choice at the +4 position was also examined.
Miyasaka
Hitoshi
H
The Kansai Electric Power Co, Technical Research Center, Amagasaki, Hyogo, Japan. K448482@kepco.co.jp
Kanai
Shozo
S
Tanaka
Satoshi
S
Akiyama
Hideo
H
Hirano
Masahiko
M
D000596:Amino Acids / Q000737:chemistry; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D010442:Peptide Chain Initiation, Translational / Q000235:genetics*; D014176:Protein Biosynthesis / Q000235:genetics*; D012269:Ribosomal Proteins / Q000737:chemistry / Q000235:genetics; D014157:Transcription Factors
D000596:Amino Acids; D012269:Ribosomal Proteins; D014157:Transcription Factors