Asymmetric deactivation of racemic BINAP-Ru(II) catalysts through complete enantiomer discrimination by dimethylbinaphthylamine: highly enantioselective hydrogenation of olefin and beta-keto ester.
[reaction: see text] 3,3'-Dimethyl-2,2'-diamino-1,1'-binaphthyl (DM-DABN) is designed as a "chiral poison" (deactivator) for complete enantiomer resolution of racemic BINAP-Ru(II) catalysts in a highly enantioselective hydrogenation of beta-keto ester and kinetic resolution of racemic 2-cyclohexen-1-ol.
Mikami
Koichi
K
Department of Applied Chemistry, Tokyo Institute of Technology, 152-8552, Japan. kmikami@o.cc.titech.ac.jp
Yusa
Yukinori
Y
Korenaga
Toshinobu
T