title: Ropivacaine-induced convulsion immediately after epidural administration--a case report.
abstract: Ropivacaine is a new long-acting amide-type local anesthetic with less toxic effects compared with bupivacaine. Here, we report a case who sustained convulsion immediately after administration of epidural ropivacaine. A 75-year-old woman was scheduled for total knee replacement. Epidural catheter was inserted smoothly. After aspiration test and injection of a test dose of 3 ml of 2% lidocaine containing 15 micrograms epinephrine, 160 mg ropivacaine was administered epidurally. Unfortunately, a generalized tonic-clonic convulsion of sudden onset occurred right after ropivacaine injection. After he was given 100% oxygen and intravenous thiopental 150 mg, the patient recovered uneventfully. During the episode of convulsion sinus tachycardia at a rate of 120 beats/min without the interposal of other form of cardiac arrhythmia was noted, and respiration remained intact. This suggests that ropivacaine offers a good cardiovascular stability. This example serves as another evidence to remind us that even with a negative aspiration following epidural catheter placement and an uneventful test dose injection, inadvertent intravascular injection may still happen, particularly in the elderly.
authors: Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC. cherng1018@sinamail.com
authors: Chen-Hwan
authors: CH
authors: Cherng
authors: Chih-Shung
authors: CS
authors: Wong
authors: Shung-Tai
authors: ST
authors: Ho
mesh_terms: D000368:Aged; D000577:Amides / Q000009:adverse effects*; D000767:Anesthesia, Epidural / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000009:adverse effects*; D005260:Female; D006801:Humans; D000077212:Ropivacaine; D012640:Seizures / Q000139:chemically induced*
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine