title: Diphyllin acetylapioside, a 5-lipoxygenase inhibitor from Haplophyllum hispanicum.
abstract: The topical anti-inflammatory activity of Haplophyllum hispanicum Spach is due to the presence of arylnaphthalene-type lignans acting as 5-lipoxygenase (5-LOX) inhibitors. The effects of the methanolic extract of this species on cellular systems have been determined by HPLC-DAD analysis. Diphyllin acetylapioside proved to be the main lignan endowed with 5-LOX inhibitory activity.
authors: José Ma
authors: JM
authors: Prieto
authors: Rosa Ma
authors: RM
authors: Giner
authors: Ma Carmen
authors: MC
authors: Recio Mf
authors: Guillermo
authors: G
authors: Schinella
authors: Salvador
authors: S
authors: Máñez
authors: José Luis
authors: JL
authors: Ríos
mesh_terms: D001092:Arachidonate 12-Lipoxygenase / Q000187:drug effects / Q000378:metabolism; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D051545:Cyclooxygenase 1; D004148:Dioxolanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007527:Isoenzymes / Q000187:drug effects / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects / Q000378:metabolism
chemical_list: D004148:Dioxolanes; D006027:Glycosides; D007527:Isoenzymes; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; C103139:tuberculatin; C103138:diphyllin acetyl apioside; D001092:Arachidonate 12-Lipoxygenase; D001094:Arachidonate 5-Lipoxygenase; D051545:Cyclooxygenase 1; D011451:Prostaglandin-Endoperoxide Synthases