Comparison of the antinociceptive effect of celecoxib, diclofenac and resveratrol in the formalin test.
The peripheral antinociceptive effect of the selective COX-2 inhibitor celecoxib in the formalin-induced inflammatory pain was compared with that of resveratrol (COX-1 inhibitor) and diclofenac (non-selective COX inhibitor). Rats received local pretreatment with saline, celecoxib, diclofenac or resveratrol followed by 50 microl of either 1% or 5% formalin. Peripheral administration of celecoxib did not produce antinociception at either formalin concentration. In contrast, diclofenac and resveratrol produced a dose-dependent antinociceptive effect in the second phase of both 1% and 5% formalin test. The peripheral antinociception produced by diclofenac or resveratrol was due to a local action, as drug administration in the contralateral paw was ineffective. Results indicate that the selective COX-2 inhibitor celecoxib does not produce peripheral antinociception in formalin-induced inflammatory pain. In contrast, selective COX-1 and non-selective COX inhibitors (resveratrol and diclofenac, respectively) are effective drugs in this model of pain.
Torres-López
Jorge E
JE
Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Granjas Coapa, México, DF, Mexico.
Ortiz
Mario I
MI
Castañeda-Hernández
Gilberto
G
Alonso-López
Rosario
R
Asomoza-Espinosa
Raquel
R
Granados-Soto
Vinicio
V
D000698:Analgesia; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D004008:Diclofenac / Q000627:therapeutic use*; D005260:Female; D005557:Formaldehyde; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology*; D010146:Pain / Q000139:chemically induced; D011720:Pyrazoles; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013267:Stilbenes; D013449:Sulfonamides; D004008:Diclofenac; D005557:Formaldehyde; D000068579:Celecoxib; D000077185:Resveratrol