title: Reversible acceleration of disease progression following cyclosporin A treatment in a patient with myelodysplastic syndrome.
abstract: A 38-year-old Japanese man with myelodysplastic syndrome (MDS), whose bone marrow smears demonstrated hypercellularity, was treated with oral cyclosporin A (CsA) therapy. During the course of this therapy, the numbers of peripheral blood and bone marrow blasts increased and the level of serum lactate dehydrogenase increased. After discontinuation of CsA treatment, all of these levels rapidly decreased. We consider that CsA might accelerate disease progression in certain MDS cases.
authors: Department of Internal Medicine, Shizuoka General Hospital, Shizuoka, Japan. itomitsu-kyt@umin.ac.jp
authors: Mitsuru
authors: M
authors: Itoh
authors: Kazuhiro
authors: K
authors: Yago
authors: Hideto
authors: H
authors: Shimada
authors: Kaoru
authors: K
authors: Tohyama
mesh_terms: D000328:Adult; D000754:Anemia, Refractory, with Excess of Blasts / Q000097:blood / Q000188:drug therapy*; D044466:Asian People; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D016572:Cyclosporine / Q000627:therapeutic use*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007564:Japan; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine