Antibiotic resistance and sero-groups of shigella among paediatric out-patients in southwest Ethiopia.
OBJECTIVE
To determine the prevalence of Shigella sero-groups and resistance pattern of isolates to commonly used antibiotics in Jimma.


METHODS
Cross-sectional survey.


METHODS
The study was conducted in Jimma, southwest Ethiopia.


METHODS
A total of 384 paediatric out-patients with diarrhoea aged 14 years and below were studied.


METHODS
Stool specimens were collected from children presenting with diarrhoea using Cary-Blair transport medium and buffer treated swabs from Jimma hospital and Jimma health centre. Isolation, biochemical characterisation, sero-grouping and antibiotic sensitivity testing were performed according to standard methodology in the Microbiology laboratory of Jimma University.


RESULTS
Out of the 77 Shigella strains isolated, sero-group A comprised 29.9%, B 40.3%, C 19.5% and D 10.4%. Among all Shigella sero-groups, highest resistance was encountered to tetracycline (63.6%), ampicillin (70.1%), cephalothin (57.1%), trimethoprim-sulphamethoxazole (32.5%) and chloramphenicol (40.3%) whileleast resistance was observed to gentamicin (1.3%), polymyxin B (3.9%) and nalidixic acid (6.5%).


CONCLUSIONS
Gentamicin, polymyxin B and nalidixic acid were found to be the drugs of choice for cases related with shigellosis.
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Department of Medical Microbiology and Parasitology, Jimma University, Ethiopia.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D024881:Drug Resistance, Bacterial; D004405:Dysentery, Bacillary / Q000453:epidemiology* / Q000382:microbiology; D005002:Ethiopia / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010045:Outpatients; D015995:Prevalence; D012703:Serotyping; D012760:Shigella / Q000145:classification* / Q000187:drug effects