Asthma: T-bet--a master controller?
The transcription factors T-bet and GATA3 are important reciprocal determinants of Th1 and Th2 T helper cell differentiation. Recent evidence suggests that these factors may affect airway immunopathology in asthma.
Robinson
Douglas S
DS
Department of Allergy, National Heart and Lung Institute, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London SW7 2AZ, UK. d.s.robinson@ic.ac.uk
Lloyd
Clare M
CM
D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000503:physiopathology*; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000378:metabolism; D050990:GATA3 Transcription Factor; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D020825:T-Box Domain Proteins; D018417:Th1 Cells / Q000166:cytology* / Q000276:immunology; D018418:Th2 Cells / Q000166:cytology* / Q000276:immunology; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*; D000098815:T-bet Transcription Factor
D004268:DNA-Binding Proteins; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; C494748:Gata3 protein, mouse; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D015534:Trans-Activators; D014157:Transcription Factors