Solid-supported reagents for multi-step organic synthesis: preparation and application.
Since the early days of combinatorial chemistry solid-phase organic synthesis has been the method of choice for the production of large libraries. Solution-phase synthesis is again gaining importance especially for the synthesis of parallel arrays of smaller, focussed libraries containing single compounds with high degrees of purity. In the field of solution-phase library generation, the use of solid-supported reagents, catalysts and scavengers is emerging as a leading strategy, combining the advantages of both solid-phase organic synthesis (e.g. allowing the employment of an excess of reagent without the need for additional purification steps) and solution-phase chemistry (e.g. the ease of monitoring the progress of the reactions by applying LC-MS, TLC or standard NMR techniques). An account of some of the most recent advances in this area of research will be presented.
Ley
S V
SV
Department of Chemistry, University of Cambridge, UK. svl1000@cam.ac.uk
Baxendale
Ian R
IR
Brusotti
G
G
Caldarelli
M
M
Massi
A
A
Nesi
M
M
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D007202:Indicators and Reagents / Q000138:chemical synthesis* / Q000302:isolation & purification; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000302:isolation & purification; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
D007202:Indicators and Reagents; D009930:Organic Chemicals; D011108:Polymers