title: Endovascular aneurysm repair: Magnetic resonance monitoring of histological organization processes in the excluded aneurysm.
abstract: BACKGROUND
  The purpose of the present study was to systematically analyze the histopathologic organization processes in excluded aneurysms after endovascular stenting and to develop a noninvasive monitoring method for these processes using MRI.
  
  
  RESULTS
  In 36 mongrel dogs, autologous aortic aneurysms were created. Endovascular treatment was performed using covered stents. Follow-up was after 1 week, 6 weeks, and 6 months. MRI was performed with T2-weighted turbo-spin-echo sequences and T1-weighted spin-echo sequences and was repeated after contrast bolus with gadolinium. Histopathologic findings were correlated to signal intensities (SIs) of MRI images. SIs of distinct areas were analyzed and related to the SI of the reference tissue (SI ratio). The histological organization process was gradated in the following 4 classes: class 0, detritus without organization; classes I and II, connective tissue proliferation with increasing fiber synthesis; and class III, dense fibrous connective tissue. The SI ratios of T2-weighted images were significantly reduced from 4.76 in detritus (0) to 1.70 in dense fibrous connective tissue (III) as a function of histopathologic classes. SI ratios of T1-weighted images were reduced from 1.84 (0) to 1.12 (III). Contrast bolus with gadolinium-DTPA showed no change of SI ratio in detritus (0.99) but an increase from 1.12 (I) to 1.70 (III) as organization increased.
  
  
  CONCLUSIONS
  The histological organization of excluded aneurysms can be monitored by MRI. Progressive organization is indicated by decreasing SIs in T2- and an increasing signal increase in T1-weighted images after gadolinium bolus.
authors: Department of Radiology, University Hospital, Johannes Gutenberg University of Mainz, Germany. pitton@radiologie.klinik.uni-mainz.de
authors: Michael Bernhard
authors: MB
authors: Pitton
authors: Ralf Patrick
authors: RP
authors: Schmenger
authors: Achim
authors: A
authors: Neufang
authors: Moritz Anton
authors: MA
authors: Konerding
authors: Christoph
authors: C
authors: Düber
authors: Manfred
authors: M
authors: Thelen
mesh_terms: D000818:Animals; D001014:Aortic Aneurysm / Q000145:classification / Q000473:pathology* / Q000601:surgery*; D004285:Dogs; D017352:Echo-Planar Imaging / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D015607:Stents