Isobolographic analysis of interaction between vigabatrin and baclofen in the formalin test in mice.
Vigabatrin and baclofen given together, at doses not affecting motor performance, produced dose-dependent inhibition of both phases in the formalin test in mice. Isobolographic analysis revealed a significant synergy between both drugs in both phases of the forrmalin test.
Czuczwar
M
M
Second University Department of Anesthesiology and Intensive Therapy, Medical University, Lublin, Poland.
Kiś
J
J
Potasiński
A
A
Turski
W A
WA
Przesmycki
K
K
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001418:Baclofen / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D005557:Formaldehyde / Q000494:pharmacology; D018755:GABA Agonists / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D051379:Mice; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects*; D020888:Vigabatrin / Q000494:pharmacology*
D000700:Analgesics; D000927:Anticonvulsants; D018755:GABA Agonists; D005557:Formaldehyde; D020888:Vigabatrin; D001418:Baclofen