Synthesis of novel hydroxymethyl substituted analogues related to carbovir and neplanocin A.
Two enantiomerically pure hydroxymethyl substituted cyclopentene nucleoside analogues (42 and 53) related to carbovir and neplanocin A, respectively, were prepared from the chiral pool of iridoid glucosides. In addition two saturated hydroxymethylated analogues (44 and 45) were obtained from a protected intermediate.
Franzyk
Henrik
H
Department of Organic Chemistry, Technical University of Denmark, Lyngby.
Jensen
Søren Rosendal
SR
Olsen
Carl Erik
CE
Rasmussen
Jon Holbech
JH
D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry*; D015224:Dideoxynucleosides / Q000737:chemistry*; D009705:Nucleosides / Q000138:chemical synthesis*
D015224:Dideoxynucleosides; D009705:Nucleosides; C057503:carbovir; C031096:neplanocin A; D000241:Adenosine