Fragrance contact dermatitis - a worldwide multicenter investigation (Part III).
The purpose of this study was to determine the frequency of responses to selected fragrance materials in patients who were fragrance sensitive. 218 fragrance sensitive subjects were evaluated in eight centres worldwide with a fragrance mixture (FM) and 17 less well-studied fragrance materials. Reaction to the fragrance mixture (FM) occurred in 76% of the subjects. The (FM) detected all reactions to nerol and hydroxycitronellol and 93% of the reactions to clove bud oil. Ten fragrance materials were not detected by the FM and deserve further study: benzenepropanol, beta, beta, 3-trimethyl, hexyl-salicylate, dl-citronellol, synthetic ylang ylang oil, benzyl mixture, cyclohexyl-acetate, eugenyl methyl ether, isoeugenyl methyl ether, 3-phenyl-1-propanol, and 3, 7-dimethyl-7-methoxyoctan-2-ol.
Larsen
Walter
W
Portland, Oregon, USA. portoracle@aol.com
Nakayama
Hideo
H
Fischer
Torkil
T
Elsner
Peter
P
Frosch
Peter
P
Burrows
Desmond
D
Jordan
William
W
Shaw
Stephanie
S
Wilkinson
John
J
Marks
James
J
Sugawara
M
M
Nethercott
Marc
M
Nethercott
James
J
D000328:Adult; D000485:Allergens / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects*
D000485:Allergens; D010476:Perfume