Development of a transient monoclonal gammopathy after chemotherapy in a patient with biphenotypic acute leukemia.
The development of a IgGk monoclonal gammopathy after a phase of bone marrow aplasia following chemotherapy is described in a patient suffering from biphenotypic acute leukemia (BAL). Paraprotein was followed by the relapse of the disease and disappeared during a further chemotherapy. Paraprotein could have been caused by an additional chemotherapy-induced genetic mutation or by a dysfunction in T-B cooperation observed in the phase of reconstitution of the immune system after medullar aplasia.
Guariglia
Roberto
R
Department of Haematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Italy. roberto.guariglia@uninaz.it
Guastafierro
Salvatore
S
Annunziata
Silvana
S
Tirelli
Angelo
A
D000208:Acute Disease; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002999:Clone Cells / Q000473:pathology; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D007938:Leukemia / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D010265:Paraproteinemias / Q000139:chemically induced* / Q000209:etiology / Q000473:pathology; D010641:Phenotype