title: Integrated approach to explore the potential of marine microorganisms for the production of bioactive metabolites.
abstract: During the last 10 years marine organisms have provided a large number of new natural products. Interesting compounds have mainly been derived from macroorganisms such as sponges, ascidians, corals and bryozoans. The number of secondary metabolites from marine microorganisms is smaller, but rapidly increasing. Because of the enormous difficulties involved in harvesting products from marine animals, and the fact that some of the bioactive compounds are produced by associated bacteria, the advantages of sustainable production of bioactive metabolites by bacteria or fungi, under the protection of natural resources, seem to be very attractive for the future. This review describes current progress in the isolation and identification of novel marine microorganisms, the discovery of new secondary metabolites, the biotechnological approaches to overproduce them, as well as the evaluation and characterization of their bioactivity.
authors: Gesellschaft für Biotechnologische Forschung, Braunschweig, Germany. iwb@gbf.de
authors: Irene
authors: I
authors: Wagner-Döbler
authors: Winfried
authors: W
authors: Beil
authors: Siegmund
authors: S
authors: Lang
authors: Marinus
authors: M
authors: Meiners
authors: Hartmut
authors: H
authors: Laatsch
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D001685:Biological Factors / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D001709:Biotechnology; D004354:Drug Screening Assays, Antitumor; D008386:Marine Biology; D010802:Phylogeny; D014871:Water Microbiology
chemical_list: D000970:Antineoplastic Agents; D001685:Biological Factors