Association between maternal and child leptin levels 9 years after pregnancy complicated by gestational diabetes.
Obesity is a state of relative leptin resistance, and obesity in childhood is associated with an increased incidence of type 2 diabetes in later life. Offspring of mothers with gestational diabetes mellitus (GDM) are at increased risk of obesity. A cohort consisting of 64 mothers, 33 GDM and 31 controls screened for diabetes during the index pregnancy together with their 9-year-old offspring were studied. Our hypotheses were: 1) an elevated child leptin is associated with elevated maternal leptin in GDM mothers 9 years post delivery; and 2) child leptin at 9 years serves as a marker for incipient insulin resistance. By univariate analyses, child leptins were only significantly correlated with maternal leptins among the offspring of GDMs (OGDM) (r = 0.59; p = 0.001). By multivariate analyses, child leptin for the total study group was significantly associated with child body mass index (BMI) (R(2) = 0.65; p < 0.0001), child fasting insulin (R(2) = 0.08; p = 0.03), and female gender (R(2) = 0.28; p = 0.001). In addition, among OGDM child leptin was associated with maternal leptin (R(2) = 0.14; p = 0.005). Our results suggest that there is an association between maternal and child leptin levels 9 years after a pregnancy complicated by gestational diabetes.
Malee
M P
MP
Department of Obstetrics and Gynecology, Women and Infants' Hospital, Brown Medical School, 101 Dudley Street, Providence, RI, USA.
Verma
A
A
Messerlian
G
G
Tucker
R
R
Vohr
B R
BR
D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002648:Child; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000097:blood*; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood*; D011247:Pregnancy
D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D002784:Cholesterol