title: Endothelium: interface between coagulation and inflammation.
abstract: OBJECTIVE
  To review the involvement of endothelial cells in the pathogenesis of coagulation abnormalities during severe infection, the differential role of proinflammatory cytokines in these mechanisms, and the cross talk between coagulation and inflammation.
  
  
  METHODS
  Published articles on experimental studies of coagulation activation during inflammation and clinical studies of patients with sepsis and associated hemostatic abnormalities.
  
  
  CONCLUSIONS
  The endothelium plays a central role in all major pathways involved in the pathogenesis of the hemostatic derangement observed during severe inflammation (i.e., initiation and regulation of thrombin generation and inhibition of fibrinolysis). Rather than being a unidirectional relationship, the interaction between inflammation and coagulation involves significant cross talk in which the endothelium seems to play a pivotal role.
authors: Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
authors: Marcel
authors: M
authors: Levi
authors: Hugo
authors: H
authors: ten Cate
authors: Tom
authors: T
authors: van der Poll
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D001778:Blood Coagulation Disorders / Q000209:etiology*; D016207:Cytokines / Q000378:metabolism / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism / Q000502:physiology*
chemical_list: D016207:Cytokines; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor