title: Docetaxel and carboplatin as second-line chemotherapy for metastatic non-small cell lung cancer.
abstract: The aim of this pilot study was to evaluate the activity and toxicity of docetaxel plus carboplatin as second-line treatment in patients with metastatic non-small cell lung cancer (NSCLC). Patients received docetaxel 75 mg/m(2) followed by carboplatin AUC 5 on day 1 every 3 weeks in an out-patient setting. Twenty-six patients were enrolled; 23 patients were diagnosed stage IV disease and three patients had a IIIB disease with malignant pleural effusion. The median interval from first to second-line treatment was 3.5 months (range 1-13). Patients received a total of 101 cycles with a median number of four cycles per patient (range 1-6). Five patients achieved a partial remission (19.23%; 95% confidence interval (CI) 6.55-39.35%), 11 had stable disease (42.31%) and ten progressed (38.46%) after initiation of second-line therapy. Median survival was 243 days (95% CI 182-336 days), the median progression-free survival was 118 days (95% CI 89-170 days), and the 1-year survival rate was 25.98% (95% CI 6.33-45.63%). Moderate haematological and mild nonhaematological toxicities were observed. No treatment-related death occurred. In conclusion, docetaxel plus carboplatin as second-line regimen has a reasonable activity with good tolerance and encouraging survival data.
authors: Department of Oncology and Haematology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, D-20246, Hamburg, Germany. laack@uke.uni-hamburg.de
authors: Eckart
authors: E
authors: Laack
authors: Thorsten
authors: T
authors: Dierlamm
authors: Claudia
authors: C
authors: Knuffmann
authors: Johann
authors: J
authors: Popp
authors: Birgit
authors: B
authors: Schmied
authors: Heinz
authors: H
authors: Dürk
authors: Georg
authors: G
authors: Wacker-Backerhaus
authors: Wolfgang
authors: W
authors: Zeller
authors: Karl
authors: K
authors: Verpoort
authors: Walter
authors: W
authors: Fiedler
authors: Dieter
authors: D
authors: Kurt Hossfeld
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D018450:Disease Progression; D018572:Disease-Free Survival; D000077143:Docetaxel; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010865:Pilot Projects; D015996:Survival Rate; D043823:Taxoids; D016896:Treatment Outcome
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin; D017239:Paclitaxel