title: Changes in antioxidant status of lung tissue in experimental diabetes in rabbits.
abstract: OBJECTIVE
  Hyperglycaemia can result in oxidative stress which may affected as cellular tissue damage.
  
  
  METHODS
  After 3, 6, 12 and 24 weeks of hyperglycaemia oxidative stress related parameters were measured in lung tissue of diabetic and control rabbits.
  
  
  RESULTS
  Decreased activities of antioxidative compounds and intensification of lipid peroxidation process were found in diabetic lung.
  
  
  CONCLUSIONS
  The data obtained suggest that hyperglycaemia induces oxidative stress in lung tissue which may play an important role in pathogenesis of diabetic complications.
authors: Department of Medicinal Chemistry, Medical University of Lublin, Chodźki Str. 6, 20-093 Lublin, Poland. kzchl@asklepios.am.lublin.pl
authors: Anna
authors: A
authors: Gumieniczek
authors: Hanna
authors: H
authors: Hopkała
authors: Zbigniew
authors: Z
authors: Wójtowicz
authors: Monika
authors: M
authors: Wysocka
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D016718:Arachidonic Acid / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation; D008171:Lung Diseases / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011817:Rabbits; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D013438:Sulfhydryl Compounds; D016718:Arachidonic Acid; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D005947:Glucose