The role of the transferrin-transferrin-receptor system in drug delivery and targeting.
Exploration of the potential of site-specific and target-oriented drug delivery systems has gained interest recently. Indeed, the efficient cellular mechanism of transferrin uptake has been exploited for the delivery not only of anticancer drugs and proteins, but also of therapeutic genes into proliferating malignant cells that overexpress transferrin receptors. In particular, the transferrin receptor offers great promise in the delivery of therapeutic agents across the blood-brain barrier to the brain.
Li
Hongyan
H
Dept of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Sun
Hongzhe
H
Qian
Zhong Ming
ZM
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D016503:Drug Delivery Systems; D006801:Humans; D011990:Receptors, Transferrin / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism*
D011990:Receptors, Transferrin; D014168:Transferrin