title: MR detection of iliac bone marrow involvement by malignant lymphoma with various MR sequences including diffusion-weighted echo-planar imaging.
abstract: OBJECTIVE
  To assess the diagnostic accuracy of MR imaging for detecting bone marrow infiltration by malignant lymphoma.
  
  
  METHODS
  Fifty-three patients with malignant lymphoma underwent MR imaging and bone marrow biopsy. In 80 iliac crests of the 53 patients (13 positive specimens in 9 patients and 67 negative specimens in 44 patients), biopsy results and the signal intensity characteristics were compared. MR sequences included T1-weighted SE, T2-weighted FSE with fat suppression, FSE STIR, and diffusion-weighted EPI with fat suppression at 1.5 T.
  
  
  CONCLUSIONS
  To detect lymphoma infiltration, T1-weighted SE had the highest sensitivity (92%) and diffusion-weighted EPI with fat suppression and FSE STIR had the highest specificity (92.5% and 92%, respectively). A combination of T1-weighted SE and FSE STIR yielded the highest sensitivity and specificity (85% and 97%, respectively). A combination of T1-weighted SE and FSE STIR sequences seems to be the current choice of imaging protocol for detecting bone marrow infiltration by malignant lymphoma.
authors: Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan. yasumoto.mrad@tmd.ac.jp
authors: M
authors: M
authors: Yasumoto
authors: Y
authors: Y
authors: Nonomura
authors: R
authors: R
authors: Yoshimura
authors: K
authors: K
authors: Haraguchi
authors: S
authors: S
authors: Ito
authors: I
authors: I
authors: Ohashi
authors: H
authors: H
authors: Shibuya
mesh_terms: D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D007085:Ilium / Q000473:pathology*; D008223:Lymphoma / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity