title: Prenatal findings in a monozygotic twin pregnancy with Costello syndrome.
abstract: This report describes the prenatal findings in monozygotic twins with Costello syndrome. At 16 weeks one twin had 9 mm of nuchal oedema: coarctation of the aorta was diagnosed after birth. At 22(5/7) weeks relative macrocephaly, mild pyelectasia and moderate polyhydramnios were noted in both twins. In the following 4 weeks the polyhydramnios increased significantly without visualisation of filling of the stomach. Between 27(5/7) and 30(2/7) weeks a total of 9 l amniotic fluid was drained and at 30(4/7) weeks prelabor premature rupture of membranes (PPROM) occurred followed by premature labor and delivery. The neonatal period was complicated by growth retardation, deglutition problems, hypotonia, cardiac and respiratory problems. Both twins died on Day 57 because of respiratory insufficiency.
authors: Department of Obstetrics and Gynaecology, A. Z. Heilig Hart, Tienen, Belgium. thierry.van_den_bosch@pi.be
authors: T
authors: T
authors: Van den Bosch
authors: D
authors: D
authors: Van Schoubroeck
authors: J P
authors: JP
authors: Fryns
authors: G
authors: G
authors: Naulaers
authors: A M
authors: AM
authors: Inion
authors: K
authors: K
authors: Devriendt
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology*; D000328:Adult; D004200:Diseases in Twins; D017809:Fatal Outcome; D005260:Female; D005315:Fetal Diseases / Q000473:pathology*; D006801:Humans; D006831:Polyhydramnios; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013577:Syndrome; D014430:Twins, Monozygotic