Human hippocampal activation during transitive inference.
The medial temporal lobe contains multiple structures whose mnemonic operations need further delineation. One model posits the function of the hippocampus as a relational binder, collaborating with overlying cortices that perform encoding and retrieval operations. For instance, lesions of the hippocampus leave intact the learning of paired-associates while impairing the ability to synthesize information across pairs. We test this relational model with two PET studies of normal humans during a transitive inference task using faces that either have or lack relationships across the stimulus pairs. Both studies converge to support a relational processing model of hippocampal function.
Nagode
Jennifer C
JC
Cognitive Neuroimaging Unit (11P), Psychiatry Service, Minneapolis VAMC, One Veterans Drive, Minneapolis, MN 55417, USA.
Pardo
José V
JV
D000328:Adult; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008297:Male; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D014055:Tomography, Emission-Computed / Q000379:methods / Q000706:statistics & numerical data