CD52 expression in mantle cell lymphoma.
Mantle cell lymphoma is one of the most difficult to treat of all the non-Hodgkin's lymphomas. CAMPATH-1H, a humanized monoclonal antibody against the CD52 antigen, has been used with some success in other lymphoproliferative diseases, especially chronic lymphocytic leukemia. This report demonstrates that tumor samples from patients with mantle cell lymphoma express the CD52 antigen and suggests that CAMPATH-1H should be studied in patients with mantle cell lymphoma.
Bass
Adam J
AJ
Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA. ajb14@duke.edu
Gong
Jerald
J
Nelson
Ramona
R
Rizzieri
David A
DA
D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D000951:Antigens, Neoplasm / Q000378:metabolism*; D000074301:CD52 Antigen; D005260:Female; D005434:Flow Cytometry; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D020522:Lymphoma, Mantle-Cell / Q000737:chemistry* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000074301:CD52 Antigen; C000613862:CD52 protein, human; D006023:Glycoproteins