Tuberoside M, a new cytotoxic spirostanol saponin from the seeds of Allium tuberosum.
Tuberoside M (1), isolated from the seeds of Allium tuberosum, shows a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) with IC50 value of 6.8 microg/ml. On the basis of spectral data and chemical reaction, its structure was established as (25S)-5beta-spirostane-1beta,3beta-diol 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranoside.
Sang
Sheng-Min
SM
Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai.
Zou
Min-Liang
ML
Zhang
Xiong-Wen
XW
Lao
Ai-Na
AN
Chen
Zhong-Liang
ZL
D000490:Allium / Q000737:chemistry*; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D013057:Spectrum Analysis; D018675:Toxicity Tests; D014407:Tumor Cells, Cultured
D012503:Saponins; C467531:tuberoside M