Allopurinol-induced pustular eruption: an unusually mild case.
Pustular drug eruptions are uncommon and usually present with an acute illness. A 75-year-old-woman presented with a widespread pruritic pustular erythematous skin rash. She was otherwise well and had been commenced on allopurinol for gout 3 weeks before developing the rash. A skin biopsy was consistent with a pustular drug eruption, with features of acute generalized exanthematous pustulosis (AGEP). Allopurinol was the probable causative agent and withdrawal resulted in resolution of her eruption within 6 weeks. A diagnosis of AGEP was considered; however, this patient did not fulfil the diagnostic criteria.
Lun
Karyn
K
Queensland Skin and Cancer Foundation, Greenslopes Private Hospital, Greenslopes, Queensland, Australia. qscf@hotmail.com
Harley
Wendy
W
D000368:Aged; D000493:Allopurinol / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006074:Gout Suppressants / Q000009:adverse effects*; D006801:Humans
D006074:Gout Suppressants; D000493:Allopurinol