[Adenocarcinoma of the stomach with heterotopic ossification. Case report and discussion of the pathogenesis].
Heterotopic ossification of gastric adenocarcinomas is very rarely observed in humans. In rats such lesions could be induced by ingestion of nitroso compounds. We describe the case of a 70-year-old patient with an extended, initially spleen-infiltrating tubular adenocarcinoma of the stomach with a mucinous component, heterotopic ossifications and pronounced regressive alterations after neoadjuvant chemotherapy. Various speculations regarding the pathogenesis of heterotopic ossifications in gastrointestinal adenocarcinomas are discussed.
Baldus
S E
SE
Zentrum für Pathologie, Universität zu Köln, Joseph-Stelzmann-Strasse 9, 50931 Köln. s-e.baldus@uni-koeln.de
Mönig
S P
SP
Schneider
P M
PM
Hölscher
A H
AH
Dienes
H P
HP
D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D006801:Humans; D008297:Male; D009999:Ossification, Heterotopic / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology*