Trisomy 10 and acute myeloid leukemia.
We report the second case of trisomy 10 as the sole abnormality in acute erythroblastic leukemia (AML M6). Trisomy 10 is a rare recurring numerical chromosomal abnormality is probably linked to a myeloblast subset with CD7+ and CD33+ immunophenotype. Most of the 15 cases reported to date in the literature have been M0, M1, or M2, with one showing AML M6 morphology.
Czepulkowski
Barbara
B
Cytogenetics Department, Leukemia Sciences, The Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, UK. barbara.czepulkowski@kingshc.nhs.uk
Powell
Anthony R
AR
Pagliuca
Anthony
A
Mufti
Ghulan J
GJ
D000208:Acute Disease; D000368:Aged; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D020732:Cytogenetic Analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D014314:Trisomy