title: Expression-based strategies for discovery of genes involved in testis and ovary development.
abstract: In recent years, strategies for gene identification based on differential gene expression have become increasingly popular, due in part to the development of microarray technology. These strategies are particularly well suited to the identification of genes involved in sex determination and gonadal development, which unlike the development of other organ systems, proceeds along two very different alternative courses, depending on the sex of the embryo. We have used a high-throughput, array-based expression screen to identify several genes expressed sex-specifically in developing mouse gonads. One of these, vanin 1, appears to play a role in mediating migration of mesonephric cells into the male genital ridge. Progress in characterizing other genes arising from the screen is discussed.
authors: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
authors: Peter
authors: P
authors: Koopman
authors: Monica
authors: M
authors: Bullejos
authors: Kelly
authors: K
authors: Loffler
authors: Josephine
authors: J
authors: Bowles
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D008297:Male; D010053:Ovary / Q000196:embryology* / Q000254:growth & development; D019849:Sex Determination Processes; D012733:Sex Differentiation / Q000235:genetics*; D013737:Testis / Q000196:embryology* / Q000254:growth & development