Prevalence and response to antiretroviral therapy of non-B subtypes of HIV in antiretroviral-naive individuals in British Columbia.
In North America, the B subtype of the major group (M) of HIV-1 predominates. Phylogenetic analysis of HIV reverse transcriptase and protease sequences isolated from 479 therapy-naive patients, first seeking treatment in British Columbia between June 1997 and August 1998, revealed a prevalence of 4.4% non-B virus. A range of different subtypes was identified, including one subtype A, 11 C, two D, five CRF01_AE, and one sample that could not be reliably subtyped. Baseline CD4 courts were significantly lower in individuals harbouring the non-B subtypes (P = 0.02), but baseline viral loads were similar (P = 0.80). In this study, individuals infected with non-B variants did not have a significantly different virological response to therapy after up to 18 months.
Alexander
Christopher S
CS
Department of Medicine, University of British Columbia, Vancouver, Canada.
Montessori
Valentina
V
Wynhoven
Brian
B
Dong
Winnie
W
Chan
Keith
K
O'Shaughnessy
Michael V
MV
Mo
Theresa
T
Piaseczny
Magda
M
Montaner
Julio S G
JS
Harrigan
P Richard
PR
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D024882:Drug Resistance, Viral / Q000235:genetics; D005260:Female; D015497:HIV-1 / Q000145:classification*; D006801:Humans; D008297:Male; D019562:Viral Load
D019380:Anti-HIV Agents