[Anti-ribosomal antibodies as activity markers in systemic lupus erythematosus].
OBJECTIVE
a) to determine the prevalence of anti-ribosomal P antibodies in patients with ESL in our setting; b) to determine if there are associations between clinical signs of ESL and these autoantibodies; c) to analyze if there is any correlation between the presence of anti-P in patients with ESL and the results of other routine lab tests; and d) to assess the usefulness of implementing as routine test the determination of anti-P antibodies.


METHODS
The study included 60 patients diagnosed of ESL and 61 healthy subjects as the control group. ELISA was used to determine anti-ribosomal antibodies. Chi-square, Fisher and Student t tests were used for the statistical analyses.


RESULTS
Of the 60 patients with SLE, 29 (48%) had anti-P antibodies as determined by ELISA. No association was observed between the presence of anti-P antibodies and psychosis, depression, hepatic failure, renal failure or any other clinical signs of ESL. A correlation was found between the levels of anti-P antibodies as determined by ELISA and anti-histone, ANA and AMA antibodies.


CONCLUSIONS
The prevalence of anti-P antibodies was high among our ESL patients (48%). Their presence was not significantly associated with any clinical sign; however, an association was found with other lab markers related to the presence of active disease.
Almeida
D
D
Servicio de Medicina Interna, Sección de Reumatología, Servicio de Análisis Clínicos, Complejo Hospitalario Ntra. Sra. de la Candelaria, Carretera del Rosario s/n, 38010 Santa Cruz de Tenerife.
Antolín
J
J
Amérigo
M J
MJ
Cantabrana
A
A
Roces
A
A
Hayeck
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012269:Ribosomal Proteins / Q000276:immunology*
D001323:Autoantibodies; D015415:Biomarkers; D012269:Ribosomal Proteins