A model of tobacco smoke-induced airflow obstruction in the guinea pig.
Animal models have proven to be extremely worthwhile in the investigations of cigarette smoke-induced lung disease. We have found the guinea pig to be useful, with a large number of advantages and few disadvantages when used in our experimental circumstances. Other animal models exist, however, and the investigator should select the model that is most suited to the hypothesis to be tested.
Wright
Joanne L
JL
Department of Pathology, University of British Columbia, 2211 Westbrook Mall, Vancouver, BC, V6T 2B5, Canada. jlwright@interchange.ubc.ca
Churg
Andrew
A
D000818:Animals; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D051379:Mice; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000503:physiopathology*; D011656:Pulmonary Emphysema / Q000503:physiopathology; D051381:Rats; D012907:Smoking / Q000009:adverse effects*