Unique genetic variation revealed by a microsatellite polymorphism survey in ten wild-derived inbred strains.
Here we report on a genome polymorphism survey using 254 microsatellite markers in ten recently wild-derived inbred strains. Allele size analysis showed that the rate of polymorphism of these wild-derived mouse strains when compared with any of the common laboratory strains is on average 79.8%. We found 632 wild-derived alleles that were not present in the common laboratory strains, representing a 61% increase over the genetic variation observed in the laboratory strains. We also found that on average 14.5% of the microsatellite alleles of any given wild-derived inbred strain were unique. Our results indicate that the recently wild-derived mouse strains represent repositories of unique naturally occurring genetic variability and may prove invaluable for the study of complex phenotypes and in the construction of new mouse models of human disease.
Campino
Susana
S
Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6, Oeiras, Portugal.
Behrschmidt
Catja
C
Bagot
Sébastien
S
Guénet
Jean-Louis
JL
Cazenave
Pierre-André
PA
Holmberg
Dan
D
Penha-Gonçalves
Carlos
C
D000483:Alleles; D000818:Animals; D005787:Gene Frequency; D014644:Genetic Variation; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D018895:Microsatellite Repeats / Q000235:genetics*; D009115:Muridae; D011110:Polymorphism, Genetic