Household transmission of Streptococcus pneumoniae among siblings with acute otitis media.
Nasopharyngeal transmission of Streptococcus pneumoniae was evaluated among 23 siblings with acute otitis media (AOM). Restriction fragment length polymorphism revealed that the nasopharyngeal strains were identical between siblings in 12 of 13 clusters of AOM experienced in 11 families. This study demonstrated person-to-person transmission of S. pneumoniae, especially drug-resistant strains, among siblings with AOM.
Shimada
Jun
J
Department of Otolaryngology-Head and Neck Surgery, Wakayama Medical University, 811-1 Kimidera, Wakayama City, Wakayama 641-0012, Japan.
Yamanaka
Noboru
N
Hotomi
Muneki
M
Suzumoto
Masaki
M
Sakai
Akihiro
A
Ubukata
Kimiko
K
Mitsuda
Toshihiro
T
Yokota
Shumpei
S
Faden
Howard
H
D000208:Acute Disease; D017668:Age of Onset; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D002675:Child, Preschool; D018562:Disease Transmission, Infectious; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D009305:Nasopharynx / Q000382:microbiology; D009679:Nuclear Family; D010033:Otitis Media / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000635:transmission*; D012150:Polymorphism, Restriction Fragment Length; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents