Frequent deletion of chromosome 3 in malignant sporadic pancreatic endocrine tumors.
Pancreatic endocrine tumors (PETs) arise from neuroendocrine cells in and around the pancreas. As loss of heterozygosity (LOH) of chromosome 3 has been reported in sporadic PETs, we examined 16 sporadic PETs for LOH of 10 polymorphic DNA markers spanning both arms of chromosome 3. LOH was demonstrated in 4 of 8 (50%) sporadic PETs with hepatic metastasis, but in none of 8 sporadic PETs without hepatic involvement. The smallest common-deleted region (SCDR) mapped to 3q27-qter. Analysis of this data with the status of markers on chromosomes 1, 11, and MEN1 mutations in these 16 sporadic PETs revealed that chromosome 3q loss may be a late event in sporadic PET tumorigenesis. These data, combined with reports from other investigators, indicate that chromosome 3q27-qter may contain a tumor suppressor gene that's important in the tumorigenesis of sporadic PETs.
Guo
Sydney S
SS
Department of Surgery, West Los Angeles VA Medical Center and the UCLA School of Medicine, 90095, USA.
Arora
Charanjit
C
Shimoide
Alan T
AT
Sawicki
Mark P
MP
D000818:Animals; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D004247:DNA / Q000097:blood; D005819:Genetic Markers; D006801:Humans; D019656:Loss of Heterozygosity; D051379:Mice; D008822:Mice, Transgenic; D018895:Microsatellite Repeats; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics; D018358:Neuroendocrine Tumors / Q000235:genetics* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology
D005819:Genetic Markers; D004247:DNA