title: Trends in fluoroquinolone (ciprofloxacin) resistance in enterobacteriaceae from bacteremias, England and Wales, 1990-1999.
abstract: The Public Health Laboratory Service receives antibiotic susceptibility data for bacteria from bloodstream infections from most hospitals in England and Wales. These data were used to ascertain resistance trends to ciprofloxacin from 1990 through 1999 for the most prevalent gram-negative agents: Escherichia coli, Klebsiella spp., Enterobacter spp., and Proteus mirabilis. Significant increases in resistance were observed for all four species groups. For E. coli, ciprofloxacin resistance rose from 0.8% in 1990 to 3.7% in 1999 and became widely scattered among reporting hospitals. The prevalence of resistance in Klebsiella spp. rose from 3.5% in 1990, to 9.5% in 1996 and 7.1% in 1999, while that in Enterobacter spp. rose from 2.1% in 1990 to 10.5% in 1996 and 10.9% in 1999. For both Klebsiella and Enterobacter spp., most resistance was localized in a few centers. Resistance was infrequent and scattered in P. mirabilis, but reached a prevalence of 3.3% in 1999.
authors: Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT, UK. DLivermore@phls.nhs.uk
authors: David M
authors: DM
authors: Livermore
authors: Dorothy
authors: D
authors: James
authors: Mark
authors: M
authors: Reacher
authors: Catriona
authors: C
authors: Graham
authors: Thomas
authors: T
authors: Nichols
authors: Peter
authors: P
authors: Stephens
authors: Alan P
authors: AP
authors: Johnson
authors: Robert C
authors: RC
authors: George
mesh_terms: D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology*; D002939:Ciprofloxacin / Q000494:pharmacology* / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D004363:Drug Utilization; D004739:England / Q000453:epidemiology; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000502:physiology; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology*; D024841:Fluoroquinolones / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D010818:Practice Patterns, Physicians'; D014852:Wales / Q000453:epidemiology
chemical_list: D024841:Fluoroquinolones; D002939:Ciprofloxacin