title: Evaluation of bi-atrial pacing and single site right atrial pacing for the prevention of atrial fibrillation.
abstract: Atrial resynchronization resulting from simultaneous pacing of the atria may adjust inter- or intra-atrial asynchrony and prevent atrial fibrillation (AF). The purpose of this study was to assess the efficacy of bi-atrial pacing (BAP) in preventing AF, and the safety of this system. The effect of BAP was compared with single site right atrial pacing (RAP) in 6 patients with sick sinus syndrome and paroxysmal AF in a prospective switchover trial. P wave duration was significantly reduced during BAP (p<0.01). Pacing threshold, atrial wave amplitude and the lead impedance presented no significant differences at implant, 1 week and 3 months after implantation, respectively (NS). The number of AF episodes significantly decreased during both RAP and BAP compared with the control (p<0.01). Although the number of premature atrial contractions was significantly less during BAP than RAP (p<0.05), there were no significant differences of AF episodes between the two. The percentage of pacing was achieved in only 70% during both pacing modes. BAP was safe and reliable in this follow-up period and can prevent AF. These findings provide encouragement for further study and observation of BAP to prevent AF.
authors: Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital, Tokyo, Japan. enmomo@nifty.com
authors: Yoshihisa
authors: Y
authors: Enjoji
authors: Kaoru
authors: K
authors: Sugi
authors: Mahito
authors: M
authors: Noro
authors: Takeshi
authors: T
authors: Nakae
authors: Naoki
authors: N
authors: Tezuka
authors: Mitsuaki
authors: M
authors: Takami
authors: Ayaka
authors: A
authors: Kawase
authors: Kenta
authors: K
authors: Kumagai
authors: Tsuyoshi
authors: T
authors: Sakai
authors: Takanori
authors: T
authors: Ikeda
authors: Tetsu
authors: T
authors: Yamaguchi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000517:prevention & control*; D016280:Atrial Function, Right / Q000502:physiology*; D001919:Bradycardia / Q000150:complications; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D003327:Coronary Disease / Q000150:complications; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D018579:Patient Selection