title: Syntheses of C12,N13 heterocyclic bridged fused indenopyrrolocarbazoles.
abstract: Tandem alkylation/cyclization of indenopyrrolocarbazole 4a, a C12 carbon analogue of indolocarbazole K252c, was carried out by general solid-phase and solution-phase methods. Alkylation of fused pyrroloindenylcarbazole 4a derivatives with appropriate monoacetals of diketones afforded the corresponding C12-substituted acetal alcohols. Acid-catalyzed cyclization of these adducts yielded C12,N13-bridged tetrahydrofuran, pyran, and dioxane compounds 10-13.
authors: Department of Medicinal Chemistry, Cephalon, Inc., 145 Brandywine Parkway, West Chester, Pennsylvania 19380, USA. tunderin@cephalon.com
authors: Ted L
authors: TL
authors: Underiner
authors: John P
authors: JP
authors: Mallamo
authors: Jasbir
authors: J
authors: Singh