title: Binding capacity of rat liver glucocorticoid receptor in different periods after single neonatal benzpyrene treatment (imprinting).
abstract: Newborn rats of both sexes were treated (imprinted) with 20 microg of benzpyrene. Two hours, 2 days, 1, 2, 3 weeks, 1 month and 2 months after imprinting the liver glucocorticoid receptors were studied for binding of dexamethasone. Two-hour and 2-day values were not appreciable. One week after treatment the receptor's affinity was extremely low both in control and treated treated animals. Two weeks after imprinting a significant difference in density (lower) and affinity (higher) was observed between the male treated and control animals. At 3 weeks and one month the binding capacity of treated and control animals was equal however, at 2 months Bmax of males increased and that of females decreased significantly in the neonatally benzpyrene treated animals. This means that for the development of perinatal imprinting effect a long time is needed, and the effect is manifested after a period of lability.
authors: Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
authors: G
authors: G
authors: Csaba
authors: A
authors: A
authors: Inczefi-Gonda
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001580:Benzopyrenes / Q000494:pharmacology*; D001667:Binding, Competitive / Q000187:drug effects; D003907:Dexamethasone / Q000378:metabolism; D005260:Female; D005938:Glucocorticoids / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011965:Receptors, Glucocorticoid / Q000187:drug effects* / Q000378:metabolism*; D012016:Reference Values; D013997:Time Factors
chemical_list: D001580:Benzopyrenes; D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone