title: Conduct of clinical trials in developing countries.
abstract: Research subjects in developing countries may be especially vulnerable to exploitation. Scrupulous care should be taken to maintain the basic principles of ethical trial conduct: the right of participants to make their own informed decisions, a favorable balance of benefit to risk, good trial design, candour about results, and, above all, use of honourable investigators. Involvement of local participants in planning a trial helps ensure both culturally-sensitive protocols and consents and also maximum benefit to patients and to local research infrastructure.
authors: Orthopaedic Hospital, Los Angeles, California 90007, USA. ckasper@laoh.ucla.edu
authors: C K
authors: CK
authors: Kasper
mesh_terms: D002986:Clinical Trials as Topic / Q000941:ethics* / Q000592:standards; D003906:Developing Countries; D026690:Ethics, Clinical; D006467:Hemophilia A / Q000628:therapy*; D006801:Humans