v-Src's hold over actin and cell adhesions.
The oncoprotein v-Src and its cellular homologue (c-Src) are tyrosine kinases that modulate the actin cytoskeleton and cell adhesions. Through the concerted action of their protein-interaction and kinase domains, they are targeted to cell matrix integrin adhesions or cadherin-dependent junctions between epithelial cells, where they phosphorylate substrates that induce adhesion turnover and actin re-modelling. Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src.
Frame
Margaret C
MC
The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. mframe@beatson..gla.ac.uk
Fincham
Valerie J
VJ
Carragher
Neil O
NO
Wyke
John A
JA
D000199:Actins / Q000502:physiology*; D000818:Animals; D015820:Cadherins / Q000502:physiology; D002154:Calpain / Q000737:chemistry / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D020662:Guanine Nucleotide Exchange Factors / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009687:Nuclear Proteins / Q000502:physiology; D015688:Oncogene Protein pp60(v-src) / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D012097:Repressor Proteins; D015398:Signal Transduction
C074560:ARHGAP35 protein, human; D000199:Actins; D015820:Cadherins; D020662:Guanine Nucleotide Exchange Factors; D009687:Nuclear Proteins; D012097:Repressor Proteins; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D015688:Oncogene Protein pp60(v-src); C496050:PTK2 protein, human; D016392:Proto-Oncogene Proteins pp60(c-src); D002154:Calpain