Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification.
Control of blood pressure and of blood flow is essential for maintenance of homeostasis. The hemodynamic state is adjusted by intrinsic, neural, and hormonal mechanisms to optimize adaptation to internal and environmental challenges. In the last decade, many studies showed that modification of the mouse genome may alter the capacity of cardiovascular control systems to respond to homeostatic challenges or even bring about a permanent pathophysiological state. This review discusses the progress that has been made in understanding of autonomic cardiovascular control mechanisms from studies in genetically modified mice. First, from a physiological perspective, we describe how basic hemodynamic function can be measured in conscious conditions in mice. Second, we focus on the integrative role of autonomic nerves in control of blood pressure in the mouse, and finally, we depict the opportunities and insights provided by genetic modification in this area.
Janssen
Ben J A
BJ
Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, Universiteit Maastricht, Maastricht, 6200 MD, The Netherlands. b.janssen@farmaco.unimaas.nl
Smits
Jos F M
JF
D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D001683:Biological Clocks / Q000502:physiology; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D002395:Catecholamines / Q000097:blood; D004562:Electrocardiography; D005730:Ganglionic Blockers / Q000494:pharmacology; D006439:Hemodynamics / Q000235:genetics / Q000502:physiology*; D020407:Internet; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D011941:Receptors, Adrenergic / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology
D002395:Catecholamines; D005730:Ganglionic Blockers; D011941:Receptors, Adrenergic