Visual function and EEG reactivity in infants with perinatal brain lesions at 1 year.
The aim of this study was to examine the correlation between EEG, visual, and brain MRI findings in 19 term infants with perinatal brain lesions. All 19 had their visual acuity and visual fields assessed and had an EEG and a brain MRI performed at 1 year of age. Four of the five infants with normal optic radiations and occipital cortices on MRI had normal vision. Involvement of optic radiations and occipital cortices was only associated with visual abnormalities in eight of 14 infants. The correlation between visual abnormalities and EEG findings was stronger. All infants with a completely normal EEG from the posterior regions had normal vision and all those with an EEG non-reactive to eye closure had visual abnormalities, irrespective of MRI data. A reactive EEG with other abnormal features (such as spikes, rapid or slow activities) was accompanied by abnormal vision in five of eight participants. Results suggest that there is a better correlation between visual function and EEG activity than between visual function and involvement of the classical visual areas of the occipital cortex and optic radiations on brain MRI at 1 year of age.
Biagioni
E
E
Visual Development Unit, University College of London, UK.
Cioni
G
G
Cowan
F
F
Rutherford
M
M
Anker
S
S
Atkinson
J
J
Braddick
O J
OJ
Canapicchi
R
R
Guzzetta
A
A
Mercuri
E
E
D000200:Action Potentials; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002544:Cerebral Infarction / Q000150:complications* / Q000175:diagnosis; D015331:Cohort Studies; D004569:Electroencephalography; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications* / Q000175:diagnosis; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests; D012640:Seizures / Q000209:etiology; D014786:Vision Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D014787:Vision Tests; D014792:Visual Acuity; D014794:Visual Fields