title: Role of interleukin-18 in host defense against disseminated Candida albicans infection.
abstract: In mice injected intravenously with Candida albicans, administration of anti-interleukin-18 (IL-18) antibodies increased the yeast load in the kidneys. There was no effect on the organ load with Candida when gamma interferon (IFN-gamma)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-gamma.
authors: Department of Medicine, University Medical Center St. Radboud, Nijmegen, The Netherlands.
authors: Rogier J L
authors: RJ
authors: Stuyt
authors: Mihai G
authors: MG
authors: Netea
authors: Ineke
authors: I
authors: Verschueren
authors: Giamila
authors: G
authors: Fantuzzi
authors: Charles A
authors: CA
authors: Dinarello
authors: Jos W M
authors: JW
authors: Van Der Meer
authors: Bart Jan
authors: BJ
authors: Kullberg
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000097:blood / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology*; D007375:Interleukin-1 / Q000097:blood; D020382:Interleukin-18 / Q000097:blood / Q000276:immunology*; D015850:Interleukin-6 / Q000097:blood; D007668:Kidney / Q000276:immunology / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D018345:Mice, Knockout; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D007375:Interleukin-1; D020382:Interleukin-18; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma