title: Clinical application of a new bioabsorbable artificial dura mater.
abstract: OBJECTIVE
  In their pursuit of a better substitute for dura mater in neurosurgical procedures, the authors review their experience with GM972.
  
  
  METHODS
  A newly developed synthetic dural substitute composed of bioabsorbable polymers (GM972) was placed in 53 patients during neurosurgical procedures. The handling properties of the material, surgical wound features. and findings of hematological, computerized tomography, and/or magnetic resonance imaging examinations were evaluated. The average follow-up period was 35.5 months. The handling properties and biocompatibility of this new dural substitute were highly satisfactory, and no significant complication was observed. In patients who underwent a second surgery performed more than 18 months after the initial operation, this new dural substitute was found to have been replaced by autologous collagenous tissue. Because of its bioabsorbability, chronic foreign body reactions to this synthetic dural substitute were negligible.
  
  
  CONCLUSIONS
  In this report the authors support the effectiveness and safety of this bioabsorbable artificial dural substitute that provides a reduced risk of transmission of latent infection.
authors: Department of Neurosurgery, Graduate School of Medicine, National Cardiovascular Center, Kyoto University, Japan.
authors: Keisuke
authors: K
authors: Yamada
authors: Susumu
authors: S
authors: Miyamoto
authors: Motohiro
authors: M
authors: Takayama
authors: Izumi
authors: I
authors: Nagata
authors: Nobuo
authors: N
authors: Hashimoto
authors: Yoshito
authors: Y
authors: Ikada
authors: Haruhiko
authors: H
authors: Kikuchi
mesh_terms: D020341:Absorbable Implants; D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D002561:Cerebrovascular Disorders / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D004388:Dura Mater / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D019569:Hemifacial Spasm / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011108:Polymers; D019919:Prosthesis Implantation; D014277:Trigeminal Neuralgia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*
chemical_list: D011108:Polymers