Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
Streptomyces platensis (strain NRRL 18993), a producer of dorrigocins, was shown to produce migrastatin, a cyclic congener of dorrigocin A previously reported from a different organism. Additionally a new compound isomeric to migrastatin, isomigrastatin, was also isolated and its structure was determined to be a cyclic form of dorrigocin B. Both compounds were fully characterized from MS and NMR data. Product titers of both were improved by the addition of XAD-16 resin to the fermentation medium.
Woo
Elaine J
EJ
Kosan Biosciences, Inc, Hayward, CA 94545, USA.
Starks
Courtney M
CM
Carney
John R
JR
Arslanian
Robert
R
Cadapan
Lawrence
L
Zavala
Stefan
S
Licari
Peter
P
D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification*; D005285:Fermentation; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D018942:Macrolides; D015394:Molecular Structure; D010881:Piperidones / Q000737:chemistry / Q000302:isolation & purification*
D000903:Antibiotics, Antineoplastic; D007783:Lactones; D018942:Macrolides; D010881:Piperidones; C455261:isomigrastatin; C418199:migrastatin