Behavioral effect of herbal glycoside in the forced swimming test.
We investigated the behavioral effects of Chinese herbal medicines in the forced swimming test. One of these medicines, Kami-shoyo-san, induced an antidepressive climbing behavior in mice. An effective substance detected to be an O-linked glycoside with the sugar chain structure GalNAc alpha 1-3GalNAc was separated. The behavioral effect was dose-dependently decreased by the dopamine 2 antagonist sulpiride, but not by the dopamine 1 antagonist SCH-233960. Investigated Chinese herbal medicines, including Kami-shoyo-san, have been used for human depression. These facts suggest that glycoside is one of the antidepressant-like substances of Chinese herbal medicines.
Masuda
Y
Y
Psychosomatic Division, Akita University School of Medicine, Akita, Japan.
Ohnuma
S
S
Sugawara
J
J
Kawarada
Y
Y
Sugiyama
T
T
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D020835:Medicine, Kampo; D051379:Mice; D008815:Mice, Inbred Strains; D013550:Swimming
D004365:Drugs, Chinese Herbal; D006027:Glycosides