Enantioselective direct-addition of terminal alkynes to imines catalyzed by copper(I)pybox complex in water and in toluene.
Highly enantioselective direct alkyne-imine additions catalyzed by Cu(I)OTf and Evan's pybox ligands were developed in water and in toluene. The process is simple and provides a diverse range of propargylic amine in high ee and good yield.
Wei
Chunmei
C
Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.
Li
Chao-Jun
CJ
D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D010293:Pargyline / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D011437:Propylamines / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014050:Toluene / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000480:Alkynes; D007097:Imines; D009942:Organometallic Compounds; D011437:Propylamines; D014867:Water; C009054:propargylamine; D014050:Toluene; D003300:Copper; D010293:Pargyline