Life is a journey: a genetic look at neocortical development.
Although the basic principles of neocortical development have been known for quite some time, it is only recently that our understanding of the molecular mechanisms that are involved has improved. Such understanding has been facilitated by genetic approaches that have identified key proteins involved in neocortical development, which have been placed into signalling pathways by molecular and cell-biological studies. The challenge of current research is to understand the manner in which these various signalling pathways are interconnected to gain a more comprehensive picture of the molecular intricacies that govern neocortical development.
Gupta
Amitabh
A
Department of Pathology, Harvard Medical School, Howard Hughes Medical Institute, 200 Longwood Avenue, Boston, Massachusetts 02115, USA. amitabh-gupta@student.hms.harvard.edu
Tsai
Li-Huei
LH
Wynshaw-Boris
Anthony
A
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology; D002465:Cell Movement / Q000235:genetics* / Q000502:physiology; D051360:Cyclin-Dependent Kinase 5; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D000089622:Doublecortin Domain Proteins; D004398:Dyneins / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000502:physiology; D019579:Neocortex / Q000196:embryology* / Q000502:physiology*; D009419:Nerve Tissue Proteins; D009474:Neurons / Q000502:physiology; D009479:Neuropeptides / Q000235:genetics / Q000502:physiology; D000091042:Reelin Protein; D012697:Serine Endopeptidases; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology
D015816:Cell Adhesion Molecules, Neuronal; D000089622:Doublecortin Domain Proteins; D016326:Extracellular Matrix Proteins; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D000091042:Reelin Protein; D051360:Cyclin-Dependent Kinase 5; C495906:Cdk5 protein, mouse; D018844:Cyclin-Dependent Kinases; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C513190:Pafah1b1 protein, mouse; D012697:Serine Endopeptidases; D004398:Dyneins