Modification of adriamycin pharmacokinetics by direct electric current in rats.
Adriamycin (ADR, doxorubicin), a drug having cardiotoxicity, is electrically charged as a cation in blood. We therefore investigated whether iontophoresis caused by direct electric current (DC; 50 microA, 90 min) would cause systemic modification of ADR pharmacokinetics. Cathode and anode were placed into a right kidney and muscles of the abdominal wall, respectively, in six Donryu rats. Urinary excretion of ADR, as measured by catheterizing into the right kidney, was significantly higher in the DC group than in the controls (p < 0.05). Both plasmic and renal ADR clearances were significantly higher in the DC group (p<0.005 and p<0.001, respectively). Tissue ADR concentrations were significantly lower in the DC group (heart: p<0.003; liver and lung: both p<0.05). These results suggest that electric therapy might potentially induce modification of ADR pharmacokinetics by iontophoresis, and that the therapy might effectively change ADR concentration both locally and systemically.
Ando
Hideyuki
H
Department of Surgery II, Nagoya University School of Medicine, Nagoya 466-8550, Japan.
Ito
Katsuki
K
Wang
Li
L
Hibi
Kenji
K
Hidemura
Kazuhiko
K
Yamazaki
Taiji
T
Kasai
Yasushi
Y
Akiyama
Seiji
S
Nakao
Akimasa
A
D000009:Abdominal Muscles / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics*; D004317:Doxorubicin / Q000493:pharmacokinetics*; D004599:Electric Stimulation Therapy; D007478:Iontophoresis; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin