title: Effects of thyroid hormone on mRNAs of phosphoglycerate mutase subunits in rat muscle during development.
abstract: BACKGROUND
  We previously showed that triiodothyronine (T3) stimulates muscle phosphoglycerate mutase (PGAM) activity and isozyme transition in rat skeletal and cardiac muscles.
  
  
  METHODS
  The effects of T3 on PGAM types B and M subunit expression in rat muscle during development are reported.
  
  
  RESULTS
  T3 administration during the first 21 days of rat life more than doubles type M PGAM mRNA levels, but produces minor effects on type B PGAM mRNA levels. The antihormone propylthiouracil (PTU) slightly decreases both type B and M mRNA levels, but this decrease is not statistically significant.
  
  
  CONCLUSIONS
  Thyroid hormone influences PGAM mRNA isozyme levels differently and increases type M mRNA.
authors: Unitat de Bioquimica, Departament de Ciéncies Fisiològiques I, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Facultat de Medicina, Universitat de Barcelona, Spain.
authors: Núria
authors: N
authors: González-Cinca
authors: Sergio
authors: S
authors: Gonzalo
authors: Carlos
authors: C
authors: Ascaso
authors: José
authors: J
authors: Carreras
authors: Fernando
authors: F
authors: Climent
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D013956:Antithyroid Agents / Q000494:pharmacology; D015152:Blotting, Northern; D003720:Densitometry; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D006321:Heart / Q000187:drug effects / Q000254:growth & development*; D007527:Isoenzymes / Q000096:biosynthesis / Q000235:genetics; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development*; D009132:Muscles / Q000187:drug effects / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D010736:Phosphoglycerate Mutase / Q000096:biosynthesis* / Q000235:genetics; D011441:Propylthiouracil / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013963:Thyroid Hormones / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology
chemical_list: D013956:Antithyroid Agents; D007527:Isoenzymes; D012333:RNA, Messenger; D013963:Thyroid Hormones; D014284:Triiodothyronine; D011441:Propylthiouracil; D010736:Phosphoglycerate Mutase