Synthesis and enzymatic characterization of P1-thio-P2-oxo trideoxynucleoside diphosphates having AZT, FdU, or dT at the 3'-position.
Model compounds for oligonucleotide-prodrugs, P1-thio-P2-oxo-trideoxyribonucleoside diphosphates: d[G(s)C(o)X] and d[T(s)A(o)X] (X = AZT, FdU or dT) have been prepared, and their hydrolyses by snake venom phosphodiesterase and nuclease S1 are described.
Otvös
László
L
Chemical Research Center, Institute of Chemistry, Hungarian Academy of Sciences, Budapest.
Bajor
Zoltán
Z
Kraicsovits
Ferenc
F
Sági
Gyula
G
Tegyey
Zsuzsanna
Z
D005468:Fluorodeoxyuridylate / Q000737:chemistry / Q000378:metabolism; D006868:Hydrolysis; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D015719:Single-Strand Specific DNA and RNA Endonucleases / Q000378:metabolism; D015215:Zidovudine / Q000737:chemistry* / Q000378:metabolism
D009705:Nucleosides; D005468:Fluorodeoxyuridylate; D015215:Zidovudine; D015719:Single-Strand Specific DNA and RNA Endonucleases; D010727:Phosphoric Diester Hydrolases; D043264:Phosphodiesterase I; C470790:phosphodiesterase I, snake venom