Vasopressin in cardiovascular patients: therapeutic implications.
Vasopressin is a vital homeostatic protein which regulates fluid balance via its antidiuretic effects and vascular tone via its vasoconstrictive effects. Endogenous vasopressin deficiency has been implicated in several disease states resulting in vasodilatory shock. In particular, vasopressin levels are low in patients following cardiac surgery and in those with ventricular dysrhythmias. Several recent studies have demonstrated the effectiveness of exogenous vasopressin in providing haemodynamic support in patients with postcardiopulmonary bypass vasodilatory shock and refractory ventricular fibrillation. This manuscript reviews the pathophysiological and clinical basis for vasopressin replacement in patients with cardiovascular collapse.
Zimmerman
Michael A
MA
Division of Cardiothoracic Surgery, Box C-310, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA. Michael.Zimmerman@uchsc.edu
Albright
Tracy N
TN
Raeburn
Christopher D
CD
Selzman
Craig H
CH
D016887:Cardiopulmonary Resuscitation; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000601:surgery; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000627:therapeutic use; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D011184:Postoperative Period; D014667:Vasopressins / Q000502:physiology / Q000627:therapeutic use
D006490:Hemostatics; D014667:Vasopressins; D003894:Deamino Arginine Vasopressin