Solid-phase synthesis of 3-alkylamino-1,2,4-triazoles.
[reaction: see text] A solid-phase synthesis of trisubstituted 3-alkylamino-1,2,4-triazoles has been developed. The synthesis utilizes immobilized N-acyl-1H-benzotriazole-1-carboximidamides as key intermediates. Cyclization with hydrazines under mild conditions furnishes the title compounds with regioselectivity and high purity.
Makara
Gergely M
GM
NeoGenesis Pharmaceuticals, 840 Memorial Drive, Cambridge, Massachusetts 02139, USA. gregm@neogenesis.com
Ma
Yao
Y
Margarida
Laura
L
D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D006834:Hydrazines / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D014230:Triazoles / Q000737:chemistry*
D006834:Hydrazines; D007202:Indicators and Reagents; D014230:Triazoles