Oxidative stress, plant-derived antioxidants and liver fibrosis.
There is accumulating evidence that oxidative stress plays a considerable role in the development of liver fibrosis by acting in different cell types and in different signaling pathways. Consequently, antioxidants, particularly those of plant origin, have emerged as potent antifibrotic agents. This review briefly summarizes current views of the mechanisms of fibrogenesis and recent findings on the antifibrotic potential of plant-derived antioxidants.
Gebhardt
R
R
Institut of Biochemistry, University of Leipzig, Germany. rgebhardt@medizin.uni-liepzig.de
D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001682:Biological Availability; D016207:Cytokines / Q000378:metabolism; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D007728:Kupffer Cells / Q000187:drug effects; D008103:Liver Cirrhosis / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010944:Plants / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000378:metabolism*; D018125:Receptors, Transforming Growth Factor beta; D015398:Signal Transduction / Q000187:drug effects; D016896:Treatment Outcome
D000975:Antioxidants; D016207:Cytokines; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D018125:Receptors, Transforming Growth Factor beta