Biological properties of the angiotensin peptides other than angiotensin II: implications for hypertension and cardiovascular diseases.
Several peptides of the RAS other than angiotensin (1-8) have been identified. They are generally referred as 'angiotensin fragments': Ang (2-8), Ang (3-8) and Ang (1-7) and have been detected in human tissues. There is evidence that they may play a functional role in humans by acting in concert with angiotensin (1-8) and aldosterone. Available knowledge on the pathways leading to synthesis and degradation of angiotensin fragments, as well as on their interactions with receptors and on their possible role in cardiovascular homeostasis and disease are reviewed.
Cesari
Maurizio
M
Department of Clinical and Experimental Medicine, University of Padua, Italy. mcesari@hotmail.com
Rossi
Gian Paolo
GP
Pessina
Achille Cesare
AC
D000809:Angiotensins / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D010446:Peptide Fragments / Q000502:physiology
D000809:Angiotensins; D010446:Peptide Fragments