Cardiac effects of salvia miltiorrhiza/dalbergia odorifera mixture, an intravenously applicable Chinese medicine widely used for patients with ischemic heart disease in China.
Chronotropic, inotropic and coronary vasodilator actions of the clinically available ampoule preparation of Salvia miltiorrhiza/Dalbergia odorifera mixture were examined using canine isolated, blood-perfused heart preparations. The mixture slightly decreased the sinoatrial rate and significantly increased coronary blood flow, but hardly affected the developed tension of the papillary muscle. The effect on coronary blood flow was induced by at least a 10-fold smaller dose than that which induced the chronotropic effect. These results were quite similar to those of a typical calcium channel blocker, verapamil, used in a previous study, suggesting that the Salvia miltiorrhiza/Dalbergia odorifera mixture may have potential as an anti-anginal drug.
Sugiyama
Atsushi
A
Department of Pharmacology, Yamanashi Medical University, Japan. atsushis@res.yamanashi-med.ac.jp
Zhu
Bing-Mei
BM
Takahara
Akira
A
Satoh
Yoshioki
Y
Hashimoto
Keitaro
K
D000818:Animals; D002681:China; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008516:Medicine, Chinese Traditional; D009200:Myocardial Contraction / Q000187:drug effects*; D017202:Myocardial Ischemia / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D027824:Rosaceae; D014665:Vasodilator Agents / Q000494:pharmacology*
D010936:Plant Extracts; D014665:Vasodilator Agents