Nutritional regulators of the hypothalamic-pituitary axis in pigs.
Nutritional signals are detected by the central nervous system (CNS) and translated by the neuroendocrine system into signals that alter secretion of LH and growth hormone (GH). Furthermore, these signals directly affect the activity of the pituitary gland independently of CNS input. Insulin-like growth factor I (IGF-I), insulin, leptin and specific metabolites, such as glucose and free fatty acids (FFA), are potential signals of the metabolic status to the brain-pituitary axis. Intravenous injection of a lipid emulsion or glucose suppressed the GH and LH response to GH releasing hormone (GHRH) and GnRH, respectively. Insulin and IGF-I regulation of LH and GH secretion occur at the pituitary gland. Feed deprivation for 24 h suppressed leptin secretion without affecting LH or GH secretion, whereas central administration of leptin resulted in a decrease in feed intake and an increase in GH secretion. Oestrogen-induced leptin gene expression in adipose tissue increased with age and adiposity in pigs. Leptin stimulated GnRH release from hypothalamic tissue in vitro. These results identify putative signals that link metabolic status and neuroendocrine control of growth and reproduction by altering endocrine function during periods of fasting, feed restriction and lactation.
Barb
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CR
Animal Physiology Research Unit, USDA/ARS, Richard B. Russell Agriculture Research Center, PO Box 5677, Athens, GA 30604, USA. rbarb@saa.ars.usda.gov
Kraeling
R R
RR
Rampacek
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GB
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D004734:Energy Metabolism; D005230:Fatty Acids, Nonesterified / Q000502:physiology; D005260:Female; D005947:Glucose / Q000502:physiology; D013006:Growth Hormone / Q000378:metabolism / Q000502:physiology; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007328:Insulin / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D020738:Leptin / Q000502:physiology; D007986:Luteinizing Hormone / Q000378:metabolism / Q000502:physiology; D010902:Pituitary Gland / Q000378:metabolism; D012098:Reproduction / Q000502:physiology*; D013552:Swine / Q000502:physiology*
D005230:Fatty Acids, Nonesterified; D007328:Insulin; D020738:Leptin; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone; D013006:Growth Hormone; D005947:Glucose