title: Proton nuclear magnetic resonance characterisation of glycosaminoglycans using chemometric techniques.
abstract: Various types of glycosaminoglycans (GAGs) including heparins, chondroitin sulfates, dermatan sulfate and hyaluronic acid were studied from their proton nuclear magnetic resonance (1H NMR) spectra using chemometric techniques. Despite the complexity of the 1H NMR signals, data analysis using principal component analysis enabled the different GAG classes to be distinguished and permitted their classification according to their chemical structure. The analysis of the composition of the major disaccharide unit and other relevant chemical structures in the heparin samples was performed using partial least squares regression.
authors: Department of Analytical Chemistry, University of Barcelona, Spain.
authors: Victoria
authors: V
authors: Ruiz-Calero
authors: Javier
authors: J
authors: Saurina
authors: Santiago
authors: S
authors: Hernández-Cassou
authors: M Teresa
authors: MT
authors: Galceran
authors: Lluis
authors: L
authors: Puignou
mesh_terms: D019075:Electrophoresis, Capillary; D006025:Glycosaminoglycans / Q000032:analysis*; D019906:Nuclear Magnetic Resonance, Biomolecular; D012815:Signal Processing, Computer-Assisted
chemical_list: D006025:Glycosaminoglycans