Post-transplant lymphoproliferative disorders: T-cell lymphoma following cardiac transplant.
Post-transplant lymphoproliferative disorders (PTLD) are a frequently fatal complication occurring after transplant. The majority of cases are of B-cell origin but a smaller percentage of cases are of T-cell origin. The etiology of these disorders is unclear, however, EBV (Epstein-Barr virus) in the context of immunosuppression is thought to play a role, particularly in B-cell PTLD. We report a case of T-cell PTLD limited to the bone marrow occurring eight years post-cardiac transplantation and review the literature on T-cell PTLD after heart transplant.
Haldas
Jason
J
Department of Medicine, Medical University of South Carolina, Charleston 29403, USA.
Wang
Wei
W
Lazarchick
John
J
D001853:Bone Marrow / Q000473:pathology; D017809:Fatal Outcome; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged