title: Comparison of primary thyroid lymphoma with anaplastic thyroid carcinoma on computed tomographic imaging.
abstract: OBJECTIVE
  Primary non-Hodgkin's lymphoma (LY) and anaplastic carcinoma (AC) of the thyroid gland are rare malignant tumors, and the initial symptoms of these diseases are very similar. The aim of our study was to compare the characteristics of the two diseases using computed tomographic (CT) scans in order to make an accurate differential diagnosis.
  
  
  METHODS
  Ten patients with LY and 10 with AC were analyzed. Differences in the CT findings of the two diseases were evaluated before treatment and statistically tested with either Student's t-test or the chi-square test.
  
  
  RESULTS
  In the analysis of characteristics of CT imaging, the existence of calcification and necrosis, and heterogeneous tumor were dominant findings in AC, and there was a statistically significant difference in frequency between the two diseases (p < 0.01). Calcification detected in AC was usually multiple and/or gross (mean size: phi8.2 mm). All lymphadenopathies were delineated as having the same homogeneous attenuation as the tumors in the thyroid gland in LY, but were shown as irregular rim enhancement in AC.
  
  
  CONCLUSIONS
  The CT features of the two diseases are characteristic in terms of calcification, necrosis, and tumor composition. Evaluation by means of CT imaging is useful in distinguishing between LY and AC.
authors: Department of Radiology and Radiation Oncology, Gunma University School of Medicine, Maebashi, Japan.
authors: Hitoshi
authors: H
authors: Ishikawa
authors: Yoshio
authors: Y
authors: Tamaki
authors: Mitsuhiro
authors: M
authors: Takahashi
authors: Keiko
authors: K
authors: Higuchi
authors: Kouji
authors: K
authors: Sakaino
authors: Tetsuo
authors: T
authors: Nonaka
authors: Mariko
authors: M
authors: Shioya
authors: Norio
authors: N
authors: Mitsuhashi
authors: Hideo
authors: H
authors: Niibe
mesh_terms: D000368:Aged; D002114:Calcinosis / Q000000981:diagnostic imaging; D002277:Carcinoma / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging*; D008297:Male; D009336:Necrosis; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed