title: Voltammetric investigation of beta-estradiol.
abstract: Electrooxidation of beta-estradiol was investigated using a glassy carbon electrode (GCE) by cyclic voltammetry (CV), and differential pulse voltammetry (DPV). The statistical analysis of the linear relationships between concentration and peak current permits the quantitation of beta-estradiol by both CV and DPV in the concentration range of 4 x 10(-5)-10(-3) M with enough precision and accuracy. A mechanism was proposed about the electrooxidation of this substance. The methods were applied to a tablet form and a transdermal therapeutic system (TTS) of this drug. The results were statistically compared with those of official high performance liquid chromatography (HPLC) method and the differences were found as insignificant.
authors: Ministry of Agriculture, P.K. 36 Yenimahalle 06 170, Ankara, Turkey.
authors: Bülent
authors: B
authors: Salci
authors: Inci
authors: I
authors: Biryol
mesh_terms: D000279:Administration, Cutaneous; D002021:Buffers; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D004566:Electrodes; D004958:Estradiol / Q000032:analysis* / Q000097:blood; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D012997:Solvents; D013607:Tablets
chemical_list: D002021:Buffers; D012997:Solvents; D013607:Tablets; D004958:Estradiol