title: Surgical treatment of mitral regurgitation associated with enlarged left ventricle.
abstract: OBJECTIVE
  Few long-term results exist of mitral valve replacement (MVR) in patients with chronic mitral regurgitation (MR) and severely enlarged left ventricle. Hence, the present study was conducted to provide additional data in this respect.
  
  
  METHODS
  Between April 1988 and September 2000, 45 patients (28 males, 17 females; mean age 33.8+/-10.5 years; range: 13-58 years) with a left ventricular (LV) diastolic diameter (LVDD) >70 mm underwent MVR at Anzhen Hospital. MR was rheumatic in origin in 36 patients (80%) and congenital in nine (20%). Thirteen patients were in NYHA class II, and 32 in classes III -IV. The cardiothoracic ratio was 0.64+/-0.12 (range: 0.47-0.84). The ECG showed LV hypertrophy to be present in all patients. Echocardiography showed severe MR and LV hypertrophy in all patients: LVDD was 76.3+/-4.1 mm (range: 70.2-89.6 mm). MVR was performed under hypothermic cardiopulmonary bypass.
  
  
  RESULTS
  Two of 45 patients died perioperatively (mortality rate 4.4%). At two weeks after surgery, echocardiography showed a reduction in LVDD (from 76.3+/-6.5 to 65.0+/-5.2 mm) (p <0.01). Follow up was completed in 37 patients (82%). Mean follow up was 4.69 years (range: 1-12.33 years). Nine patients were in NYHA class I, 21 in class II, and five in class III. Late mortality was 5%. LVDD was further decreased at late control from 76.3+/-6.5 to 60.0+/-6.1 mm (p <0.001).
  
  
  CONCLUSIONS
  MVR is indicated in patients with mitral insufficiency and highly dilated ventricles. In addition, perioperative mortality was acceptable and late results satisfactory. Moreover, the intervention has the potential to reduce severe LV dilation, and in some cases to revert ventricular size to normal.
authors: Department of Cardiac Surgery, Institute of Heart, Lung and Blood Vessel, Anzhen Hospital, Capital Medical University, Beijing, China.
authors: Li
authors: L
authors: Wenbin
authors: Zhang
authors: Z
authors: Jianqun
authors: Zhou
authors: Z
authors: Qiwen
authors: Chen
authors: C
authors: Baotian
authors: Xu
authors: X
authors: Xiufang
authors: Zhang
authors: Z
authors: Zhaoguang
authors: Zhang
authors: Z
authors: Wukui
mesh_terms: D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage; D002681:China; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D013318:Stroke Volume / Q000502:physiology; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants