Effect of alloantisera on the immune response of rat spleen cells against sheep red blood cells in vitro.
Alloantisera directed against antigens determined by the major histocompatibility system or by the genetic background of the rat are able to completely inhibit the primary IgM immune response of rat spleen cells against sheep red blood cells in vitro. Full inhibition is elicited only when the alloantisera are added during the first 48 hours of cultivation. Alloantisera that inhibit a primary immune response do not inhibit a secondary IgM response to sheep red blood cells in vitro by spleen cells primed 10-28 days before.
Bhakdi-Lehnen
B
B
Max-Planck-Institut für Immunbiologie, D-78 Freiburg, Postfach 1169, Fed. Rep. Germany.
Günther
E
E
D000818:Animals; D020296:Animals, Congenic; D003602:Cytotoxicity, Immunologic; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D007075:Immunoglobulin M / Q000096:biosynthesis; D066298:In Vitro Techniques; D007518:Isoantibodies / Q000008:administration & dosage*; D008213:Lymphocyte Activation; D051381:Rats; D011917:Rats, Inbred Lew; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000276:immunology*
D007075:Immunoglobulin M; D007518:Isoantibodies