title: Transgenic rice is a source of iron for iron-depleted rats.
abstract: Iron deficiency is one of the most prevalent nutrient deficiencies in the world. A sustainable solution to dietary iron deficiency may be achieved in part by increasing bioavailable iron in seeds used for foods such as rice. Because ferritin is used as a natural source of iron in the early development of humans, other animals and plants, the bioavailability of iron in rice seeds, provided in amounts equal to ferrous sulfate, and in transgenic rice with ferritin was tested in iron-deficient rats. A standard hemoglobin (Hb) repletion bioassay was used with rats made anemic followed by complete diets containing equivalent amounts of iron as FeSO(4) or one of three different bioengineered rice varieties (Kitaake and two transgenic derivatives with ferritin targeted to the seed, FK11 and FK22). Rice diets were as effective as the FeSO(4) diet in replenishing hematocrit, Hb concentration and liver iron concentrations. These data suggest that Mendelian and biotechnological approaches to manipulating ferritin expression of seed iron in rice may contribute to a sustainable solution to global problems of iron deficiency.
authors: Department of Nutrition, The Pennsylvania State University, University Park, PA, USA.
authors: Laura E
authors: LE
authors: Murray-Kolb
authors: Fumio
authors: F
authors: Takaiwa
authors: Fumiyuki
authors: F
authors: Goto
authors: Toshihiro
authors: T
authors: Yoshihara
authors: Elizabeth C
authors: EC
authors: Theil
authors: John L
authors: JL
authors: Beard
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000453:epidemiology / Q000517:prevention & control*; D000818:Animals; D001682:Biological Availability; D001709:Biotechnology; D004032:Diet; D005293:Ferritins / Q000032:analysis* / Q000378:metabolism; D005296:Ferrous Compounds / Q000493:pharmacokinetics; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D019266:Iron, Dietary / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D012275:Oryza / Q000235:genetics*; D030821:Plants, Genetically Modified; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds
chemical_list: D005296:Ferrous Compounds; D006454:Hemoglobins; D019266:Iron, Dietary; C020748:ferrous sulfate; D005293:Ferritins