title: Supplemental fructooligosaccharides and mannanoligosaccharides influence immune function, ileal and total tract nutrient digestibilities, microbial populations and concentrations of protein catabolites in the large bowel of dogs.
abstract: The goal of this study was to examine whether supplemental fructooligosaccharides (FOS) and (or) mannanoligosaccharides (MOS) influenced indices of gut health of dogs. Adult female dogs (n = 4) surgically fitted with ileal cannulas were fed a dry, extruded, kibble diet twice daily. At each feeding, the following treatments were administered: 1) Control (no FOS or MOS); 2) 1 g FOS; 3) 1 g MOS; or 4) 1 g FOS + 1 g MOS. Fecal, ileal and blood samples were collected during the last 4 d of each 14-d period to measure protein catabolite concentrations, microbial populations, immune characteristics and nutrient digestibilities. Treatment means were compared using preplanned orthogonal contrasts. Dogs supplemented with MOS had lower (P = 0.05) fecal total aerobes and tended to have greater (P = 0.13) Lactobacillus populations. Ileal immunoglobulin (Ig) A concentrations were greater (P = 0.05) in dogs supplemented with FOS + MOS vs. control. Lymphocytes (% of total white blood cells) were greater (P < 0.05) in dogs supplemented with MOS. Serum IgA concentrations also tended (P = 0.13) to be greater in dogs supplemented with MOS. Dogs supplemented with FOS and FOS + MOS had lower (P < 0.05) fecal total indole and phenol concentrations. Dogs supplemented with MOS tended to have lower ileal DM (P = 0.149) and OM (P = 0.146) digestibilities vs. control. Results of this study suggest that dietary supplementation of FOS and MOS may have beneficial effects on colonic health and immune status of dogs.
authors: Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA.
authors: Kelly S
authors: KS
authors: Swanson
authors: Christine M
authors: CM
authors: Grieshop
authors: Elizabeth A
authors: EA
authors: Flickinger
authors: Laura L
authors: LL
authors: Bauer
authors: Hans-Peter
authors: HP
authors: Healy
authors: Karl A
authors: KA
authors: Dawson
authors: Neal R
authors: NR
authors: Merchen
authors: George C
authors: GC
authors: Fahey
mesh_terms: D000818:Animals; D001419:Bacteria / Q000254:growth & development; D002404:Catheterization; D003106:Colon / Q000378:metabolism / Q000382:microbiology; D019587:Dietary Supplements; D004063:Digestion / Q000187:drug effects; D004285:Dogs / Q000378:metabolism* / Q000382:microbiology; D005227:Fatty Acids / Q000378:metabolism; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D005260:Female; D007082:Ileum / Q000276:immunology / Q000378:metabolism*; D007070:Immunoglobulin A / Q000032:analysis; D008351:Mannans / Q000008:administration & dosage / Q000378:metabolism; D009844:Oligosaccharides / Q000008:administration & dosage* / Q000378:metabolism; D011506:Proteins / Q000032:analysis / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D007070:Immunoglobulin A; D008351:Mannans; D009844:Oligosaccharides; D011506:Proteins; C116580:fructooligosaccharide