Lack of MHC expression and retention of ultrastructural characteristics by xenograft transmissible venereal tumor cells in SCID mice.
Canine transmissible venereal tumor (CTVT) is primarily a tumor of adult dogs with a high incidence of spontaneous regression. We recently reported a xenograft model of CTVT (XTVT) in NOD/SCID mice. XTVT cells retain cytological and histological features of CTVT as well as characteristic rearranged LINE/c-MYC junction [Am. J. Vet. Res. 62 (2001) 907]. In this paper, we demonstrate that XTVT cells maintain ultrastructural characteristics of CTVT and do not express MHC classes I and II molecules.
Harmelin
A
A
Department of Veterinary Resources, The Weizmann Institute of Science, Rehobot 76100, Israel. alon.harmelin@weizmann.ac.il
Pinthus
J H
JH
Friedmann-Morvinski
D
D
Kaufman
K
K
Brenner
O
O
D000818:Animals; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000276:immunology* / Q000473:pathology; D004285:Dogs; D005434:Flow Cytometry; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology; D005805:Genes, MHC Class I / Q000276:immunology; D005802:Genes, MHC Class II / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology / Q000502:physiology*; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D013047:Specific Pathogen-Free Organisms; D014183:Transplantation, Heterologous; D014685:Venereal Tumors, Veterinary / Q000276:immunology* / Q000473:pathology / Q000648:ultrastructure