Repeated treatment with SA4503, a selective sigma1 receptor agonist, up-regulates alpha-adrenergic system. a behavioral study.
The obtained results indicate that SA4503, a selective sigma1 receptor agonist, given repeatedly (but not acutely) enhanced the effects of phenylephrine, alpha1-adrenoceptor agonist, and clonidine (stimulating the postsynaptic alpha1-adrenoceptors at high dose) in behavioral models (hyperexploratory activity in rats and aggressiveness in mice, respectively).
Skuza
G
G
Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Kolasiewicz
W
W
D000284:Administration, Oral; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000374:Aggression / Q000187:drug effects*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D051379:Mice; D018697:Nootropic Agents / Q000494:pharmacology*; D010656:Phenylephrine / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism*; D017480:Receptors, sigma / Q000819:agonists*; D015854:Up-Regulation
D000316:Adrenergic alpha-Agonists; D018697:Nootropic Agents; D010879:Piperazines; D018340:Receptors, Adrenergic, alpha-1; D017480:Receptors, sigma; D010656:Phenylephrine; C101789:SA 4503; D003000:Clonidine