title: Capillary leak syndrome after cardiopulmonary bypass in elective, uncomplicated coronary artery bypass grafting operations: does it exist?
abstract: OBJECTIVE
  Operations coupled with cardiopulmonary bypass may provoke a systemic inflammatory response, and it has been suggested that this responses causes capillary leakage of proteins, edema formation, and even organ failure. However, capillary leak syndrome is mainly a clinical diagnosis and has not been verified as yet by actual demonstration of protein leakage from the circulation. We have therefore measured the disappearance of labeled plasma protein before and after cardiopulmonary bypass.
  
  
  METHODS
  Sixteen patients scheduled for elective coronary artery bypass grafting were enrolled in a prospective controlled study. The cardiopulmonary bypass circuit was primed with crystalloids only. Tumor necrosis factor alpha, interleukin 6, interleukin 8, anaphylatoxin C3a, and terminal complement complex C5b9 levels were determined before, during, and 3 hours after cardiopulmonary bypass. The transvascular escape rate of plasma protein from the intravascular compartment was assessed by measuring the disappearance of intravenously injected Evans blue dye before and during the third hour after cardiopulmonary bypass.
  
  
  RESULTS
  A significant inflammatory response could be demonstrated by means of the 5 measured mediators after bypass. The maximal increase, as compared with the baseline value, was found for interleukin 6 (36-fold). The transvascular escape rate of Evans blue dye was similar before and after bypass (7.6 +/- 0.6%/h vs 7.3 +/- 0.6%/h).
  
  
  CONCLUSIONS
  The above data confirm the systemic inflammatory response induced by cardiopulmonary bypass. Contrary to expectations, the transvascular escape rate of Evans blue dye did not change when comparing values before and after bypass. The data do not support the concept of increased protein leakage in the exchange vessels after bypass. We were unable to demonstrate a capillary leak syndrome.
authors: Department of Anesthesiology, Deutsches Herzzentrum München, Germany. tassani@dhm.mhn.de
authors: P
authors: P
authors: Tassani
authors: H
authors: H
authors: Schad
authors: C
authors: C
authors: Winkler
authors: A
authors: A
authors: Bernhard
authors: U
authors: U
authors: Ettner
authors: S L
authors: SL
authors: Braun
authors: G P
authors: GP
authors: Eising
authors: E
authors: E
authors: Kochs
authors: R
authors: R
authors: Lange
authors: J A
authors: JA
authors: Richter
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000150:complications / Q000601:surgery; D019559:Capillary Leak Syndrome / Q000097:blood / Q000209:etiology*; D002315:Cardiopulmonary Bypass; D003131:Combined Modality Therapy; D015926:Complement C3a / Q000378:metabolism; D015938:Complement Membrane Attack Complex / Q000378:metabolism; D001026:Coronary Artery Bypass; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009997:Osmotic Pressure; D011182:Postoperative Care; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology; D011300:Preoperative Care; D011446:Prospective Studies; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015938:Complement Membrane Attack Complex; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D015926:Complement C3a