Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation.
A 26-year-old woman with acute myeloid leukemia underwent allogeneic peripheral blood stem cell transplantation from an HLA-identical brother. Eighteen days after transplantation, the patient developed grade II acute graft-versus-host disease (GVHD) and was treated with corticosteroids. On day 38, the patient complained of eye pain and lacrimation. A slitlamp examination revealed corneal ulcers and pseudomembranous formation in both eyes. Histologic and immunohistochemical examinations of the pseudomembrane disclosed an infiltrate dominated by T cells. A cytogenetic study of the pseudomembrane by fluorescence in situ hybridization identified a Y chromosome in the infiltrated mononuclear cells. Surveillance cultures from conjunctival swabs were negative. Thus, we diagnosed these ocular manifestations as an ocular involvement of acute GVHD.
Saito
Takashi
T
Second Department of Internal Medicine, Okayama University Medical School, Japan.
Shinagawa
Katsuji
K
Takenaka
Katsuto
K
Matsuo
Keitaro
K
Yoshino
Tadashi
T
Kiura
Katsuyuki
K
Niiya
Kenji
K
Harada
Mine
M
D000328:Adult; D005128:Eye Diseases / Q000209:etiology / Q000473:pathology*; D005260:Female; D006086:Graft vs Host Disease / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*