Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults.
There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.
Pendleton
Neil
N
Clinical Gerontology Group, Clinical Division I, University of Manchester, Hope Hospital, Stott Lane, Salford, M6 8HD, UK. npendlet@fs1.ho.man.ac.uk
Payton
Anthony
A
van den Boogerd
Eelke H
EH
Holland
Fiona
F
Diggle
Peter
P
Rabbitt
Patrick M A
PM
Horan
Michael A
MA
Worthington
Jane
J
Ollier
William E R
WE
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D053329:Apolipoprotein E2; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics*; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011237:Predictive Value of Tests; D012737:Sex Factors; D013223:Statistics as Topic
D053329:Apolipoprotein E2; D053327:Apolipoprotein E4; D001057:Apolipoproteins E