Spliceosomal snRNAs: Mg(2+)-dependent chemistry at the catalytic core?
Since the discovery of self-splicing RNAs, it has been suspected that the snRNAs are the catalytic components of the spliceosome. Recent evidence supports both the catalytic potential of the spliceosomal snRNAs and their resemblance to elements of group II introns.
Villa
Tommaso
T
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.
Pleiss
Jeffrey A
JA
Guthrie
Christine
C
D000818:Animals; D020134:Catalytic Domain / Q000235:genetics*; D019143:Evolution, Molecular; D006801:Humans; D008274:Magnesium / Q000378:metabolism*; D008954:Models, Biological; D015394:Molecular Structure; D012326:RNA Splicing / Q000235:genetics*; D012342:RNA, Small Nuclear / Q000235:genetics*; D017381:Spliceosomes / Q000235:genetics*
D012342:RNA, Small Nuclear; D008274:Magnesium