Role of matrix metalloproteinase-7 in angiogenesis associated with age-related macular degeneration.
To investigate the possible role of matrix metalloproteinase-7 in choroidal neovascularization associated with age-related macular degeneration, immunoelectron microscopy using ultrathin frozen sections and conventional transmission electron microscopy were performed in subfoveal fibrovascular membranes from patients with age-related macular degeneration. immunoelectron microscopy revealed that matrix metalloproteinase-7 was expressed within basal laminar deposits and amorphous materials around the retinal pigment epithelial cells. The results support a role for matrix metalloproteinase-7 in the development of choroidal neovascularization in age-related macular degeneration.
Yazama
Futoshi
F
Department of Anatomy, School of Medicine, Yokohama City University, Kanagawa, Japan. fyzma@med.yokohama-cu.ac.jp
Kadonosono
Kazuaki
K
Itoh
Norihiko
N
Ohno
Shigeaki
S
D000367:Age Factors; D000368:Aged; D020256:Choroidal Neovascularization / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008268:Macular Degeneration / Q000201:enzymology* / Q000473:pathology; D008297:Male; D020783:Matrix Metalloproteinase 7 / Q000378:metabolism*; D008854:Microscopy, Electron; D016253:Microscopy, Immunoelectron; D010857:Pigment Epithelium of Eye / Q000201:enzymology* / Q000648:ultrastructure
D020783:Matrix Metalloproteinase 7