Dietary L-carnitine increases plasma insulin-like growth factor-I concentration in chicks fed a diet with adequate dietary protein level.
1. The effect of L-carnitine supplemented into experimental diets with varying dietary protein concentrations (50, 200 and 400 g/kg) on body weight gain and plasma insulin-like growth factor-I (IGF-I) concentration in chicks was examined. 2. Dietary L-carnitine supplementation provided 0, 200, 500 and 1000 mg/kg. Chicks were given the diet ad libitum for 10 d. 3. When L-carnitine was provided as 500 or 1000 mg/kg, body weight gain was significantly improved in birds receiving the 200 and 400 g protein/kg diets. 4. There was an interaction between dietary L-carnitine and protein content on plasma IGF-I concentration. L-carnitine supplementation had little influence on plasma IGF-I concentrations in birds receiving the low protein (50 g/kg) diet. When dietary L-carnitine concentrations were increased from 0 to 1000 mg/kg in the adequate protein (200 g/kg) diet, plasma IGF-I concentrations were also increased. However, when dietary L-carnitine content was more than 500 mg/kg in the 400 g/kg protein group, plasma IGF-I concentration decreased with increasing dietary L-carnitine content. 5. Body weight change correlated significantly with the alteration in plasma IGF-I concentrations in chicks given diets with adequate dietary protein. 6. In conclusion, the improvement in body weight gain caused by dietary L-carnitine supplementation was achieved when chicks were given their dietary protein requirement, which may be partially explained by an increase in plasma IGF-I concentration.
Kita
K
K
Laboratory of Grassland Science, University Farm, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan. kitak@agr.nagoya-u.ac.jp
Kato
S
S
Amanyaman
M
M
Okumura
J
J
Yokota
H
H
D000418:Albumins / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D002331:Carnitine / Q000378:metabolism / Q000494:pharmacology*; D002645:Chickens / Q000097:blood / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D008297:Male; D014280:Triglycerides / Q000097:blood
D000418:Albumins; D001786:Blood Glucose; D001798:Blood Proteins; D004044:Dietary Proteins; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D007334:Insulin-Like Growth Factor I; D002784:Cholesterol; D002331:Carnitine