Predictors of HIV-specific lymphocyte proliferative immune responses induced by therapeutic vaccination.
We treated a cohort of 38 HIV-infected individuals with a therapeutic vaccine (REMUNE, HIV-1 Immunogen) in an open label study. We then determined whether baseline parameters, such as CD4 cell count, viral load and IgG levels, were predictive of the magnitude of the HIV-specific lymphocyte proliferative responses (LPRs). We demonstrate herein that there is a significant enhancement from baseline for both HIV and p24 antigen-stimulated LPRs after immunization. Using a responder definition of a stimulation index of >5 on at least two post-immunization time-points, 29/38 (76%) responded to HIV-1 antigen while 27/38 (71%) responded to native p24 antigen. Viral load and total IgG were negatively correlated, while CD4 cell counts were positively associated with the magnitude of the HIV antigen LPR. In a multivariable analysis, baseline CD4 was the best predictor of HIV antigen LPR post-immunization.
Moss
R B
RB
The Immune Response Corporation, Carlsbad, CA 92008, USA. shotdoc@imnr.com
Wallace
M R
MR
Steigbigel
R T
RT
Morrison
S A
SA
Giermakowska
W K
WK
Nardo
C J
CJ
Diveley
J P
JP
Carlo
D J
DJ
D016915:AIDS Vaccines / Q000276:immunology* / Q000627:therapeutic use; D015704:CD4 Antigens / Q000276:immunology; D018791:CD4 Lymphocyte Count; D015488:HIV Antigens / Q000276:immunology; D015658:HIV Infections / Q000097:blood / Q000276:immunology* / Q000628:therapy*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008213:Lymphocyte Activation; D011237:Predictive Value of Tests; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D019562:Viral Load
D016915:AIDS Vaccines; D015704:CD4 Antigens; D015488:HIV Antigens; D007074:Immunoglobulin G; C105086:remune