Lactobacillus fermentum RC-14 inhibits Staphylococcus aureus infection of surgical implants in rats.
Staphylococcus aureus is a common cause of community and hospital-acquired infections. Moreover, the clinical impact of S. aureus is on the rise because of the global increase in the incidence of multidrug-resistant strains and its growing prevalence as a major cause of surgical infections. As a result, there is a pressing need to identify new antistaphylococcal agents and preventative strategies that will help in the management of these types of infections. This report describes the successful use of a probiotic, Lactobacillus fermentum RC-14, and its secreted biosurfactant to inhibit surgical implant infections caused by S. aureus. L. fermentum RC-14 and its secreted biosurfactant both significantly inhibited S. aureus infection and bacteria adherence to surgical implants.
Gan
Bing Siang
BS
Hand and Upper Limb Centre, Lawson Health Research Institute, Department of Surgery, University of Western Ontario, London, Canada.
Kim
Juan
J
Reid
Gregor
G
Cadieux
Peter
P
Howard
Jeffrey C
JC
D000818:Animals; D001422:Bacterial Adhesion; D007778:Lactobacillus / Q000502:physiology*; D008297:Male; D019736:Prostheses and Implants / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000302:isolation & purification*