title: Symptomatic and physiologic outcomes after operative treatment for extraesophageal reflux.
abstract: BACKGROUND
  Pharyngeal pH monitoring has recently been used to identify patients with extraesophageal symptoms induced by gastroesophageal reflux. We employed this method of acid detection to evaluate patients with respiratory symptoms prior to and after laparoscopic Nissen fundoplication to further elucidate the relationship between GERD and respiratory symptoms.
  
  
  METHODS
  Twenty-one consecutive patients with extraesophageal symptoms thought to be caused by reflux underwent symptomatic and functional evaluation (esophageal manometry and 24-h pH monitoring with a pharyngeal probe) before and after laparoscopic Nissen fundoplication. Episodes of pharyngeal acid exposure were considered abnormal if the pH dropped below 4, occurred simultaneously with esophageal acidification, and occurred outside meal times.
  
  
  RESULTS
  All patients had gastroesophageal reflux disease (GERD) and respiratory symptoms; nine of 15 (60%) had evidence of pharyngeal reflux preoperatively. Antireflux procedures resulted in a significant decrease in pharyngeal reflux (7.9 to 1.6 episodes/24h; p <0.05) and esophageal acid exposure (7.5% to 2.1%; p <0.05). In patients with pharyngeal reflux and complete postoperative testing, three (60%) obtained improvement of respiratory symptoms and resolution of pharyngeal reflux. In two patients with recurrent respiratory symptoms after surgery, persistent pharyngeal reflux was detected.
  
  
  CONCLUSIONS
  Operative treatment of GERD is effective in controlling extraesophageal reflux, measured subjectively and objectively. Evidence of pharyngeal reflux on pH testing helps to identify which patients with respiratory symptoms will benefit from an antireflux procedure.
authors: Department of Surgery, Swallowing Center, University of Washington, 1959 N.E. Pacific Street, Seattle, WA 98195-6410, USA. brant@u.washington.edu
authors: B K
authors: BK
authors: Oelschlager
authors: T R
authors: TR
authors: Eubanks
authors: D
authors: D
authors: Oleynikov
authors: C
authors: C
authors: Pope
authors: C A
authors: CA
authors: Pellegrini
mesh_terms: D003371:Cough / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D004947:Esophagus / Q000502:physiology / Q000503:physiopathology / Q000601:surgery; D005500:Follow-Up Studies; D018662:Fundoplication / Q000379:methods; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010535:Laparoscopy / Q000379:methods; D008365:Manometry / Q000379:methods; D018670:Monitoring, Ambulatory / Q000379:methods; D010608:Pharyngeal Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D010614:Pharynx / Q000502:physiology / Q000503:physiopathology; D011446:Prospective Studies; D012135:Respiratory Sounds / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome