Analysis of gene expression of lymphocytes in microgravity.
It has been reported that lymphocyte function decreases under microgravity. Though molecular mechanism of the immunosuppression in microgravity still remains enigmatic, it is suggested that gene expression of lymphocytes may be altered in microgravity. In this study we developed automatic flash-freezing equipment which can be utilized for exposing lymphocytes to microgravity by drop shaft experiments in Japan Microgravity Center (JAMIC). Gene expression profiles were analyzed by using DNA array in ground control lymphocytes and microgravity-exposed lymphocytes.
Torigoe
T
T
Department of Pathology 1, Sapporo Medical University School of Medicine.
Ichinohe
T
T
Sato
N
N
Yano
S
S
D005615:Freezing; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D014893:Weightlessness