Use of transgenic models to understand effects of exercise on glucose metabolism.
This review will focus on the achievements obtained using transgenic animals in our understanding of exercise-induced insulin sensitivity as well as the regulation of glycogen storage in skeletal muscle, including the effects of acute exercise and insulin on the major determinants: glycogen synthesis and glucose uptake.
Hansen
Bo F
BF
Department of Diabetes Biology, Novo Nordisk, Bagsvaerd, Denmark.
Wojtaszewski
Jørgen F P
JF
D000818:Animals; D030801:Animals, Genetically Modified; D015444:Exercise / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D051272:Glucose Transporter Type 1; D051275:Glucose Transporter Type 4; D006003:Glycogen / Q000378:metabolism; D006006:Glycogen Synthase / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D009004:Monosaccharide Transport Proteins / Q000378:metabolism / Q000502:physiology; D009124:Muscle Proteins; D018482:Muscle, Skeletal / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*
D051272:Glucose Transporter Type 1; D051275:Glucose Transporter Type 4; D007328:Insulin; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; C495677:SLC2A1 protein, human; C495692:SLC2A4 protein, human; C495693:Slc2a4 protein, mouse; D006003:Glycogen; D006006:Glycogen Synthase; D005947:Glucose