title: [Camptocormia, a rare form of motor system disorders in Parkinson's disease].
abstract: Camptocormia is characterized by pronounced forward flexion of the thoracolumbar spine, which increases while walking and disappears in recumbent position. The clinical spectrum of the described disorders with concomitant camptocormia is heterogenous. It was described for the first time in idiopathic Parkinson's disease in 1999. The pathophysiology of this phenomenon remains unclear but seems to be not related to antiparkinsonian treatment. The authors present the case of a 54 years old woman, with idiopathic Parkinson disease diagnosed 5 years ago. The rapid progression of the disease was associated with good response to Levodopa therapy, although the dose had to be increased up to 1400 mg/d (with peripheral decarboxylase and COMT inhibitor). After 5 years she developed painful spasms of paraspinal muscles which resulted in trunk flexion. The clinical picture resembled the described cases of camptocormia. There was no correlation between the appearance of camptocormia and the regime of levodopa administration (time or dosage). Therefore, one can conclude, that presumably camptocormia is not a form of dystonia of the trunk but, the result of till now unclear other factors (dysfunction in other non-dopaminergic nigrostriatal projections?).
authors: Wojewódzkiego Oddziału Neurologii Szpitala Specjalistycznego św. Wojciecha-Adalberta w Gdańsku.
authors: J
authors: J
authors: Sławek
authors: M
authors: M
authors: Derejko
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D011187:Posture; D013122:Spinal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa