Preparation and Antibacterial Activity of 3-Methyl-1-p-substituted Phenylpyrazole-5-thiol.
3-Methyl-1-phenylpyrazole-5-thiol (3a) and its p-nitro-(5) and p-fluorophenyl (8) derivatives were prepared as potential antimicrobial agents in relatively good yields. Compounds 3a and 8 showed good antibacterial activities against MRSA, S. aureus, S. epidermidis, E. faecalis, E. faecium, and S. pyogenes. Moreover, compound 3a also showed a synergistic effect with some aminoglycosides.
Tagawa
Yoshinobu
Y
Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Minami
Shin'ichi
S
Yoshida
Toshio
T
Tanaka
Keitaro
K
Sato
Shuji
S
Goto
Yoshinobu
Y
Yamagata
Kenji
K