[Therapeutic effects of a new taurine derivative in chronic hepatic diseases].
Therapeutic properties of a novel taurin N-phenylakyl derivative (TAU-15) in a dose 25 mg/kg were studied in male rats on models of chronic toxic hepatitis and partial hepatectomy. A hepatoprotective action of TAU-15 was established which is due to antioxidative action of TAU-15 and its ability to normalize protein-synthetizing activity of hepatocytes.
Khnychenko
L K
LK
Bul'on
V V
VV
Sapronov
N S
NS
Kudriashova
N I
NI
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006498:Hepatectomy; D006521:Hepatitis, Chronic / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009336:Necrosis; D051381:Rats; D013654:Taurine / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D000975:Antioxidants; D013654:Taurine; D008315:Malondialdehyde