title: The presence of 4-hydroxyphenylacetic acid in human saliva and the possibility of its nitration by salivary nitrite in the stomach.
abstract: Human saliva contained 4-hydroxyphenylacetic acid (HPA) (2-10 microM) and nitrite (60-300 microM). HPA was nitrated to 4-hydroxy-3-nitrophenylacetic acid (NO2HPA) when HPA and sodium nitrite were mixed at pH 1.0. NO2HPA was also formed when saliva was incubated under acidic conditions. These results suggest that salivary HPA is nitrated to NO2HPA when saliva is swallowed into the stomach.
authors: Kyushu Dental University, 803-8580, Kitakyushu, Japan. takahama@kyu-dent.ac.jp
authors: Umeo
authors: U
authors: Takahama
authors: Takayuki
authors: T
authors: Oniki
authors: Hideaki
authors: H
authors: Murata
mesh_terms: D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009573:Nitrites / Q000032:analysis; D009596:Nitrophenols / Q000378:metabolism*; D010648:Phenylacetates / Q000032:analysis* / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D012977:Sodium Nitrite / Q000378:metabolism
chemical_list: D009573:Nitrites; D009596:Nitrophenols; D010648:Phenylacetates; C026242:4-hydroxy-5-nitrophenyl acetic acid; C008070:4-hydroxyphenylacetic acid; D012977:Sodium Nitrite