A cis amide bond surrogate incorporating 1,2,4-triazole.
A novel cis amide bond surrogate incorporating 1,2,4-triazole was designed and synthesized by the reaction of a thionotripeptide, formic hydrazide, and mercury(II) acetate. This method of surrogate formation was also applicable to a cyclic thionopeptide.
Hitotsuyanagi
Yukio
Y
School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Motegi
Shuichi
S
Fukaya
Haruhiko
H
Takeya
Koichi
K
D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D008628:Mercury / Q000737:chemistry; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D011487:Protein Conformation; D013237:Stereoisomerism; D013457:Sulfur Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry*
D000577:Amides; D009842:Oligopeptides; D010456:Peptides, Cyclic; D013457:Sulfur Compounds; D014230:Triazoles; C045575:1,2,4-triazole; D008628:Mercury; C043548:RA VII; C029823:mercuric acetate