title: Pathogenesis of hyperuricemia: recent advances.
abstract: The literature on the pathogenesis of hyperuricemia have been limited to the discussion of metabolic syndromes associated with risk factors for atherosclerosis and hyperuricemia and the genetics of the juvenile form of hyperuricemic nephropathies. A few new mutations in the hypoxanthine-guanine phosphoribosyltransferase gene, which result in Lesch-Nyhan syndrome, have been described. In addition, some new insight has been gained in the renal handling of uric acid by the human kidney.
authors: Michael Reese Hospital, Department of Internal Medicine, 2929 South Ellis Avenue, Chicago, IL 60616, USA.
authors: Manisha
authors: M
authors: Ghei
authors: Mihaela
authors: M
authors: Mihailescu
authors: Dennis
authors: D
authors: Levinson
mesh_terms: D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000235:genetics / Q000503:physiopathology*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid