title: Prevalence and response to antiretroviral therapy of non-B subtypes of HIV in antiretroviral-naive individuals in British Columbia.
abstract: In North America, the B subtype of the major group (M) of HIV-1 predominates. Phylogenetic analysis of HIV reverse transcriptase and protease sequences isolated from 479 therapy-naive patients, first seeking treatment in British Columbia between June 1997 and August 1998, revealed a prevalence of 4.4% non-B virus. A range of different subtypes was identified, including one subtype A, 11 C, two D, five CRF01_AE, and one sample that could not be reliably subtyped. Baseline CD4 courts were significantly lower in individuals harbouring the non-B subtypes (P = 0.02), but baseline viral loads were similar (P = 0.80). In this study, individuals infected with non-B variants did not have a significantly different virological response to therapy after up to 18 months.
authors: Department of Medicine, University of British Columbia, Vancouver, Canada.
authors: Christopher S
authors: CS
authors: Alexander
authors: Valentina
authors: V
authors: Montessori
authors: Brian
authors: B
authors: Wynhoven
authors: Winnie
authors: W
authors: Dong
authors: Keith
authors: K
authors: Chan
authors: Michael V
authors: MV
authors: O'Shaughnessy
authors: Theresa
authors: T
authors: Mo
authors: Magda
authors: M
authors: Piaseczny
authors: Julio S G
authors: JS
authors: Montaner
authors: P Richard
authors: PR
authors: Harrigan
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D024882:Drug Resistance, Viral / Q000235:genetics; D005260:Female; D015497:HIV-1 / Q000145:classification*; D006801:Humans; D008297:Male; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents