Synthesis and cholera toxin binding properties of a lactose-2-aminothiazoline conjugate.
[structure: see text] During the search for improved monovalent ligands for cholera toxin (CT), a new lactose-2-aminothiazoline conjugate was discovered. In a fluorescence binding assay the compound was found to be one of the strongest relatively simple CT ligands to date with a K(d) of 23 microM.
Vrasidas
Ioannis
I
Department of Medicinal Chemistry, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB, The Netherlands.
Kemmink
Johan
J
Liskamp
Rob M J
RM
Pieters
Roland J
RJ
D002240:Carbohydrate Sequence; D002772:Cholera Toxin / Q000737:chemistry*; D004187:Disaccharides / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D013844:Thiazoles / Q000737:chemistry*
D004187:Disaccharides; D008024:Ligands; D013844:Thiazoles; C458199:lactose-2-aminothiazoline; D002772:Cholera Toxin