title: Fatal disseminated Candida lusitaniae infection in an infant with chronic granulomatous disease.
abstract: A 3-month-old boy born to a mother carrying an X-linked form of chronic granulomatous disease presented with persistent fever and hepatosplenomegaly. The diagnosis was confirmed as a gp91phox defect by genetic analysis, and the patient was managed with broad spectrum antibacterial agents, gamma-interferon and later amphotericin B. A liver biopsy revealed granulomata with budding yeast forms, and cultures of blood and urine grew Candida lusitaniae. The patient died 26 days after admission.
authors: Division of Infectious Diseases, Children's Hospital, Boston, MA, USA.
authors: Ofer
authors: O
authors: Levy
authors: Jean-Pierre
authors: JP
authors: Bourquin
authors: Alisa
authors: A
authors: McQueen
authors: Alan B
authors: AB
authors: Cantor
authors: Catherine
authors: C
authors: Lachenauer
authors: Richard
authors: R
authors: Malley
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*; D017809:Fatal Outcome; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000627:therapeutic use; D008297:Male
chemical_list: D000890:Anti-Infective Agents; D000998:Antiviral Agents; D000666:Amphotericin B; D007371:Interferon-gamma