Endocrine origins of rheumatic disease. Diagnostic clues to interrelated syndromes.
Heightened awareness of endocrine abnormalities is important in evaluation of patients presenting with musculoskeletal symptoms. Endocrine disorders such as diabetes, hyperthyroidism, hypothyroidism, hyperparathyroidism, hypoparathyroidism, hyperadrenocorticism, and acromegaly cause a unique array of rheumatic manifestations. Such conditions include Dupuytren's contracture, carpal tunnel syndrome, chondrocalcinosis, pseudogout, scleredema, and osteoporosis. Characteristic changes on radiologic evaluation and serum enzyme testing are additional clues to these atypical presentations. Consideration of a possible endocrine cause early in the evaluation may improve management in patients with such an underlying disorder.
Lockshin
Michael D
MD
Barbara Volcker Center, Hospital for Special Surgery, Cornell University Joan and Sanford I. Weill Medical College, Graduate School of Medical Sciences, New York, NY, USA.
D000172:Acromegaly / Q000150:complications; D048909:Diabetes Complications; D004700:Endocrine System Diseases / Q000150:complications*; D006801:Humans; D010279:Parathyroid Diseases / Q000150:complications; D012216:Rheumatic Diseases / Q000175:diagnosis* / Q000209:etiology*; D012307:Risk Factors; D013577:Syndrome; D013959:Thyroid Diseases / Q000150:complications