Parathyroidectomy in dialysis patients.
Subtotal parathyroidectomy or total parathyroidectomy (PTx) with autotransplantation are surgical procedures considered while the patient is included on the waiting list for renal transplantation. Total PTx alone is based in the possibility that a fragment of tissue (nodular hyperplasia in particular) left in the same pathophysiological environment of long term dialysis would show the same behavior and reproduce in time the same clinicopathological picture. The persistence of uremia induces a continued growth stimulus developing residual hyperplasia and consequently a very high risk of recurrence. We performed total PTx alone in 15 uremic patients excluded for renal transplantation 10 patients with undetectable iPTH serum concentration and were followed up for 37 to 144 months. There was no evidence of clinical bone disease (bone pain or fractures). Bone mineral lumbar spine and hip density was measured at the end of follow-up. The z score data showed that all patients had a bone mass similar than that expected for their age. Bone biopsies performed in four patients showed a uniform picture of low turnover without aluminium staining. Calcification of small arteries (digital and arcade vessels in hands and feet) were evaluated pre and post total PTx alone in nine out of the 10 patients with undetectable PTH levels. The small vessel calcification was present in five patients at the moment of PTx. At the end of the long term follow-up only one patient showed progression. In conclusion, total PTx without autotransplantation is a very effective and adequate treatment for refractory severe hyperparathyroidism in patients excluded for renal transplantation. Aluminium related osteopathy post PTx is a risk to be controlled with aluminium "free" dialysis water and avoiding aluminium containing phosphate binders.
de Francisco
Angel L M
AL
Servicio de Nefrología y Endocrinología, Hospital U Valdecilla, Universidad de Cantabria, Santander, Spain. martinal@unican.es
Fresnedo
Gema Fernández
GF
Rodrigo
Emilio
E
Piñera
Celestino
C
Amado
J A
JA
Arias
M
M
D002117:Calcitriol / Q000627:therapeutic use; D004351:Drug Resistance; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000175:diagnosis / Q000601:surgery*; D006965:Hyperplasia / Q000188:drug therapy; D010280:Parathyroid Glands / Q000473:pathology; D016105:Parathyroidectomy; D015995:Prevalence; D006435:Renal Dialysis; D012307:Risk Factors
D002117:Calcitriol