title: [Impact of antihypertensive treatment on target organs].
abstract: We review the mechanisms by which arterial hypertension induces target organs damage, particularly the heart, kidney, and vascular endothelium, which is manifested as ventricular hypertrophy, proteinuria, and renal failure and endothelial dysfunction. Furthermore, the effect of antihypertensive treatment in these situations is analyzed. Experimental and clinical studies show that angiotensin converting enzyme inhibitors (ACE inhibitors) and angiotensin II receptor antagonist drugs are more efficient than other antihypertensive treatments in the reversal of left ventricular hypertrophy and proteinuria, in delaying kidney damage and improving of endothelial function.
authors: Instituto Nacional de Cardiología Dr. Ignacio Chávez, INCICH, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, 14080 México, D. F.
authors: Jorge
authors: J
authors: Fregoso Padilla
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004730:Endothelium, Vascular; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000517:prevention & control*; D007674:Kidney Diseases / Q000209:etiology / Q000517:prevention & control*; D014652:Vascular Diseases / Q000209:etiology / Q000517:prevention & control
chemical_list: D000959:Antihypertensive Agents