title: Mitosis: aurora gives chromosomes a healthy stretch.
abstract: Attachment of sister chromatids to microtubules from opposite spindle poles--bi-orientation--generates tension at the kinetochores. The Ipl1/Aurora B kinase responds to the absence of tension at mono-oriented chromosomes and promotes microtubule turnover and spindle checkpoint activation until a stable bi-oriented attachment is achieved.
authors: Department of Molecular and Cell Biology, Harvard University, 16 Divinity Ave, Room 3000, Cambridge, MA 02138, USA. bstern@mcb.harvard.edu
authors: Bodo M
authors: BM
authors: Stern
mesh_terms: D064127:Aurora Kinases; D020090:Chromosome Segregation; D015825:Chromosomes, Fungal / Q000235:genetics / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D008938:Mitosis; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins; D015003:Yeasts / Q000166:cytology* / Q000235:genetics
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D029701:Saccharomyces cerevisiae Proteins; D011494:Protein Kinases; D064127:Aurora Kinases; C576961:IPL1 protein, S cerevisiae; D017346:Protein Serine-Threonine Kinases