[Correlation between IL-6 levels and polymerized human serum albumin ceptor (PHSAR) in serum of chronic hepatitis patients].
BACKGROUND
To investigate the relationship between interleukin-6 (IL-6) levels in serum and HBV replication and the role of IL-6 in liver damage in chronic hepatitis B patients.


METHODS
Detected IL-6 levels and polymerized human serum albumin receptor (PHSA-R) in serum of different type of HBV markers positive patients and of different degree of chronic hepatitis B patients.


RESULTS
The results showed that the serum IL-6 levels were increased significantly in PHSA-R positive patients than in PHSA-R negative patients in chronic hepatitis B (P<0.01). The serum IL-6 levels were correlated with the levels of PHSA-R (r=0.694, P<0.01), and the degree of symptoms.


CONCLUSIONS
This study suggested that the IL-6 levels in serum of hepatitis B patients correlated HBV replication and the degree of liver damage, serum IL-6 levels may be used as a value indicating of HBV replication, the degree of symptoms and the effect of treatment.
Li
Zhiqing
Z
323rd Hospital of PLA, Xi'an 710054, China.
Wei
Ruiquan
R
Jin
Boquan
B
D000328:Adult; D000368:Aged; D006515:Hepatitis B virus / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D017457:Receptors, Albumin / Q000097:blood*; D014779:Virus Replication
D015850:Interleukin-6; D017457:Receptors, Albumin