Dapsone for the treatment of doxorubicin extravasation injury in the rat.
Doxorubicin is the most common antitumor drug implicated in serious extravasation injuries. Progressive tissue necrosis may lead to intense pain, chronic ulceration, and disfiguring tissue loss. This progressive necrosis is analogous to that seen with brown recluse spider bites, where dapsone is an established mode of therapy, minimizing the area of tissue loss by a proposed antiinflammatory mechanism. The backs of 50 Lewis rats were injected intradermally with 1 mg of doxorubicin in 1 cc of saline to simulate an extravasation injury. The rats were divided into five groups for treatment with oral dapsone 50 mg/kg/day: 10 were controls (no treatment), 10 were started the day before injury, 10 were started the day of injury, 10 were started the day after injury, and 10 were started 1 week after injury. The area of ulceration was calculated by planimetry. The data suggest that dapsone has little positive effect on healing extravasation ulcers.
Sommer
Nicole Z
NZ
Department of Plastic Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794-9653, USA.
Bayati
Semira
S
Neumeister
Michael
M
Brown
Richard E
RE
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003622:Dapsone / Q000627:therapeutic use*; D004317:Doxorubicin / Q000009:adverse effects*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D008297:Male; D009336:Necrosis; D051381:Rats; D011917:Rats, Inbred Lew; D012867:Skin / Q000473:pathology; D012883:Skin Ulcer / Q000188:drug therapy / Q000209:etiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016166:Free Radical Scavengers; D004317:Doxorubicin; D003622:Dapsone