title: Successful multimodality therapy of recurrent multifocal juvenile granulosa cell tumor of the ovary.
abstract: Juvenile granulosa cell tumor (JGCT) of the ovary, a rare pediatric cancer, carries a very poor prognosis in advanced and recurrent cases. A 10-year-old girl with stage IA JGCT, initially treated with resection only, presented with extensive unresectable multifocal pelvic recurrence. She underwent surgery, chemotherapy (cisplatin/paclitaxel alternating with cisplatin/cyclophosphamide/etoposide/bleomycin), myeloablative chemotherapy (carboplatin/etoposide/melphalan) with autologous bone marrow transplant, and pelvic radiation. She tolerated therapy well and is in complete remission 69 months after her recurrence.
authors: Department of Pediatrics, Childrens Hospital Los Angeles, Keck School of Medicine, California 90027, USA. epstein@hsc.usc.edu
authors: Anat
authors: A
authors: Erdreich-Epstein
authors: Hector L
authors: HL
authors: Monforte
authors: Robert S
authors: RS
authors: Lavey
authors: Sarita
authors: S
authors: Joshi
authors: J Duncan
authors: JD
authors: Phillips
authors: Judith G
authors: JG
authors: Villablanca
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002648:Child; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D013502:General Surgery; D006106:Granulosa Cell Tumor / Q000473:pathology / Q000628:therapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome