[Renal function in children after treatment of acute lymphoblastic leukaemia (ALL)].
The aim of the study was to evaluate the renal function (on the basis of serum: cystatin C, creatinine, beta2-microglobulin(B2M) levels, creatinine and cystatin C clearance, and urine osmolality) in 37 children with ALL (acute lymphoblastic leukaemia) after completing intensive treatment (9 in course of maintenance therapy), depending on nephrotoxic antibiotics use (</=3 times vs > 3 times) and methotrexate dose (1.0 g/m2 vs 5g/m2). The control group was formed by 15 healthy children.


RESULTS
1) Serum cystatin C, creatinine, beta2-microglobulin levels creatinine and cystatin C clearance, and urine osmolality were similar in the analysed and control groups. 2) We did not find any differences between the analyzed parameters in the groups of children: a) in maintenance therapy and after the end of the therapy, b) received methotrexate in the dose of 5.0 g/m2 vs 1.0 g/m2, c) not treated children and treated </= 3 times and gt; 3 times with nephrotoxic antibiotics.


CONCLUSIONS
The renal function is normal after completion of antileukaemic therapy in spite of previous use of nephrotoxic drugs.
Krawczuk-Rybak
M
M
Klinika Onkologii Dzieciecej, Samodzielny Publiczny Dzieci cy Szpital Kliniczny, Akademia Medyczna, Waszyngtona 17, 15-274 Bialystok, Poland.
Kuzmicz
M
M
Kozlowska
K
K
Wysocka
J
J
Kitszel
A
A
Luczynski
W
W
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D002648:Child; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D009994:Osmolar Concentration; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D014556:Urine / Q000737:chemistry; D001613:beta 2-Microglobulin / Q000097:blood
D000970:Antineoplastic Agents; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D001613:beta 2-Microglobulin; D003404:Creatinine