title: Insensate versus painful diabetic neuropathy: the effects of height, gender, ethnicity and glycaemic control.
abstract: OBJECTIVE
  To study similarities and differences between people with insensate or painful diabetic peripheral neuropathy, particularly in relation to height, gender, ethnicity and glycaemic control.
  
  
  METHODS
  We studied prospectively 2610 patients with Type 2 diabetes attending our Diabetes Centre. Subjects were compared according to degree of sensory loss, and presence or absence of neuropathic pain. The effects of gender and ethnicity were evaluated by studying patients in different height bands.
  
  
  RESULTS
  Insensate neuropathy and painful neuropathy was present in 11.4 and 3.3% of subjects, respectively. Age, duration of diabetes, height, vibration perception and HbA(1c) (P<0.0001) were independent determinants of insensate neuropathy, whereas only duration of diabetes and vibration perception (P<0.0001) were predictive of pain. There was more insensate neuropathy in males (OR 1.9) and anglo-celtics (OR 1.4) but stratification by height showed that these effects were due to height. Height has no influence on the development of pain.
  
  
  CONCLUSIONS
  There is significant overlap but also considerable dichotomy in the two major forms of diabetic sensory peripheral neuropathy. The insensate type is more explainable by duration, degree of hyperglycaemia and length of peripheral nerves, factors that are likely to reflect severity of underlying structural nerve damage. Glycaemic control was not a predictor of painful neuropathy.
authors: Department of Medicine, University of Sydney, Newtown, Australia. lea@email.cs.nsw.gov.au
authors: Lea
authors: L
authors: Sorensen
authors: Lynda
authors: L
authors: Molyneaux
authors: Dennis K
authors: DK
authors: Yue
mesh_terms: D001315:Australia; D001786:Blood Glucose / Q000378:metabolism*; D001827:Body Height; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000145:classification / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000097:blood / Q000145:classification / Q000503:physiopathology*; D005006:Ethnicity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain; D012727:Sex Characteristics
chemical_list: D001786:Blood Glucose