title: Frequency of postoperative nausea and vomiting in patients undergoing laparoscopic foregut surgery.
abstract: BACKGROUND
  Wrap disruption or intrathoracic herniation of a fundoplication is a dreaded complication of laparoscopic foregut surgery. This problem may often be related to postoperative nausea and vomiting (PONV). This study aimed to investigate the occurrence of PONV and its management in patients undergoing laparoscopic foregut procedures.
  
  
  METHODS
  Between January 31 and May 23, 2000, 104 patients undergoing laparoscopic foregut procedures (fundoplication, myotomy, or paraesophageal hernia repair) were followed prospectively. Their postoperative course was documented along with the occurrence and management of PONV. All laparoscopic foregut surgery patients are managed postoperatively with a uniform clinical pathway, and their care is focused on a nursing unit with skill and experience in postoperative management.
  
  
  RESULTS
  Nausea was documented in the postanesthesia care unit (PACU) for 30.1% of the patients, and for 59.6% of the patients during their nursing unit stay. Antiemetics were given to all the patients with documented nausea. Emesis was noted in 1.9% of the patients in the PACU, as compared with 3.8% of the patients on the floor. In one of the patients with nursing unit emesis, an acute wrap herniation into the chest occurred, necessitating a return to the operating room for correction. The patients with a history of postoperative nausea did not have a higher rate of PONV than in those with no history of postoperative nausea. The use of preoperative or intraoperative antiemetics did not appear to alter the occurrence of PONV. Postoperative nausea occurred in 60% of the patients administered preoperative antiemetic, as compared with 64% of the patients who received no preoperative antiemetic. The average length of hospital stay was longer in those with PONV than in those with no PONV (2.6 vs 1.8 days).
  
  
  CONCLUSIONS
  Nausea after laparoscopic foregut procedures is common, occurring twice as often on the nursing unit as in the PACU. The occurrence of PONV leads to a longer hospital stay, and can result in significant sequelae requiring reoperation. The use of preoperative or intraoperative antiemetics does not alter the frequency of postoperative nausea, suggesting the need to develop effective preemptive regimens for patients undergoing laparoscopic foregut procedures. The high rate of PONV and its potential risk of damage to a fundoplication and hiatal hernia repair should lead surgeons to consider whether laparoscopic foregut procedures should ever be performed on an outpatient basis.
authors: Department of Surgery, Emory University School of Medicine, 1364 Clifton Road NE, Suite H-124B, Atlanta, GA 30322, USA.
authors: W A
authors: WA
authors: Bradshaw
authors: B C
authors: BC
authors: Gregory
authors: C R
authors: CR
authors: Finley
authors: A
authors: A
authors: Ross
authors: T
authors: T
authors: Wilds
authors: M
authors: M
authors: Still
authors: C D
authors: CD
authors: Smith
mesh_terms: D000932:Antiemetics / Q000009:adverse effects / Q000627:therapeutic use; D015992:Body Mass Index; D004943:Esophagogastric Junction / Q000601:surgery; D005260:Female; D018662:Fundoplication / Q000009:adverse effects* / Q000379:methods / Q000706:statistics & numerical data*; D006551:Hernia, Hiatal / Q000601:surgery; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects* / Q000379:methods / Q000706:statistics & numerical data*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology* / Q000517:prevention & control / Q000628:therapy; D011300:Preoperative Care / Q000009:adverse effects / Q000379:methods; D011446:Prospective Studies; D012737:Sex Factors
chemical_list: D000932:Antiemetics