Monitoring anthrax vaccine safety in US military service members on active duty: surveillance of 1998 hospitalizations in temporal association with anthrax immunization.
We compared 1998 hospitalizations in active-duty US military personnel for possible temporal association with anthrax immunization. Immunization, demographic, and hospitalization data were analyzed using Cox proportional hazards modeling for hospitalization within 42 days of vaccination. Discharge diagnoses were aggregated into 14 International Classification of Disease, Ninth Revision, Clinical Modification (ICD-9-CM) categories. Approximately 11% of subjects received one or more doses of vaccine during 1998; those immunized were more likely to be younger and male. Lower hospitalization rates were observed across doses and diagnostic categories among the immunized. Adjusted risk ratios for hospitalization by diagnostic category suggest that immunized service members were at equal or lesser risk for hospitalization than the non-immunized.
Sato
Paul A
PA
Department of Defense Center for Deployment Health Research, Naval Health Research Center, San Diego, CA 92186-5122, USA.
Reed
Robert J
RJ
Smith
Tyler C
TC
Wang
Linda
L
D000293:Adolescent; D000328:Adult; D022122:Anthrax Vaccines / Q000009:adverse effects*; D003257:Consumer Product Safety; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D011159:Population Surveillance; D016016:Proportional Hazards Models; D014481:United States; D014611:Vaccination / Q000009:adverse effects
D022122:Anthrax Vaccines