Status epilepticus after massive carbamazepine overdose.
We report two patients who experienced status epilepticus after carbamazepine overdose. The first patient was an 18-year-old female with a history of epilepsy. She experienced 4 hour of persistent and prolonged seizures resistant to sodium amytal therapy. The status epilepticus ended with her death. The second patient was an 18-year-old male with a history of bipolar disorder. He experienced 5 hour of persistent and prolonged seizures that appeared to be resistant to diazepam, phenytoin, and phenobarbital. The seizures abated with the infusion of midazolam. This is a report of status epilepticus associated with wide complex tachycardia after carbamazepine overdose, which may be resistant to conventional therapy.
Spiller
Henry A
HA
Kentucky Regional Poison Center of Kosair Children's Hospital, Louisville 40232-5070, USA. henry.spiller@nortonhealthcare.org
Carlisle
Richard D
RD
D000293:Adolescent; D000927:Anticonvulsants / Q000506:poisoning*; D002220:Carbamazepine / Q000506:poisoning*; D062787:Drug Overdose; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use; D007262:Infusions, Intravenous; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000627:therapeutic use; D013226:Status Epilepticus / Q000139:chemically induced* / Q000188:drug therapy; D013610:Tachycardia / Q000150:complications; D017211:Treatment Failure
D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D002220:Carbamazepine; D008874:Midazolam