An efficient synthesis of the new benzo[c]pyrido[2,3,4-kl]acridine skeleton.
A series of molecules of therapeutic interest, possessing the new skeleton of 1H-benzo[c]pyrido[2,3,4-kl]acridine with acyl or aminoacyl and methoxy or aminoalkoxy substituents on the aromatic homocycles were synthesized by means of a Friedländer-type reaction. The requisite 5-aminodihydroquinoline-4-ones 1, whose preparation is described, were reacted with the appropriate alpha-tetralones 2 using an acidic catalyst (PPTS) under azeotropic conditions. Optimized reaction time and yield depend on temperature, which must not be below 90 degrees C.
Chackal
Sarah
S
Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, EA 2692, rue du Professeur Laguesse, BP 83, 59006 Lille, France.
Houssin
Raymond
R
Hénichart
Jean-Pierre
JP