title: Effect of perforations in burr hole covers on cranial bone regeneration in rabbits.
abstract: The reconstruction of bone defects is a significant problem in cranio-maxillofacial surgery. In an effort to avoid the known disadvantages of autogenous bone grafting, alternatives have been investigated. Bone substitute materials, degradable or nondegradable, aim at facilitating bone regeneration, while they take over load-bearing functions for a period of time. In this study, the healing of cranial defects in rabbits was assessed using polylactide guiding covers with and without perforations. Bilateral circular cranial defects were produced in 16 New Zealand white rabbits. The defects were covered with extruded and laser cut polylactide burr hole covers, each animal receiving a perforated burr hole cover on one side and a nonperforated one on the contralateral side. Bone seeking fluorochromes were administered at regular intervals. After an observation period of 8 weeks the amount of bone regeneration in the area of the defects was quantified from contact radiographs, and the dynamics of bone formation were assessed by fluorescence microscopy. Stained sections were used to analyze morphologic differences. No signs of adverse tissue reactions or osteolysis were observed. A bone-guiding function was observed for both covers with or without perforations. Intracranial tissue herniation into the defect hindered the regeneration process. Wide intraindividual and interindividual variation became apparent and average defect filling was only 40% within the 8-week observation period. In this model the perforated covers offered no advantage over nonperforated covers. It can be concluded from this study, that the use of external burr hole covers alone does not guarantee a full thickness regeneration of the cranial defect, but it provides a guiding function for promotion of structured bone regeneration.
authors: AO Research Institute, Clavadelerstrasse, 7270 Davos Platz, Switzerland.
authors: Christoph S
authors: CS
authors: Leiggener
authors: Raymond
authors: R
authors: Curtis
authors: Dominik
authors: D
authors: Pfluger
authors: Berton A
authors: BA
authors: Rahn
mesh_terms: D020341:Absorbable Implants; D000042:Absorption; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes; D005260:Female; D008856:Microscopy, Fluorescence; D011091:Polyesters / Q000737:chemistry; D011817:Rabbits; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery
chemical_list: D018786:Bone Substitutes; D011091:Polyesters; C033616:poly(lactide)