[Polymorphism analysis of 825C/T of the G-protein beta 3 subunit in high risk population of hypertension in the northeast China].
PCR-RFLP was used for genotyping of GNB3 C/T in 133 patients with EH and 257 healthy control subjects in the high risk population and in 98 patients with EH and 110 healthy control subjects in general population. Some biochemical tests were performed also. The association between the polymorphism and blood pressure was analyzed by the case-control study. Not association between GNB3 825C/T polymorphism and blood pressure was found in both populations. CT and TT genotypes in women of the high risk population are associated with diastolic blood pressure, serum sodium and calcium. Although GNB3 is not a susceptible gene of hypertension in the northeast Chinese, it still has some effects on regulation of the blood pressure in susceptible women.
Dai
Shu-Ping
SP
Department of Medical Genetics, China Medical University, Shenyang 110001, China.
Shi
Jing-Pu
JP
Ding
Qian
Q
Wang
Hai-Long
HL
Dong
Ling-Yue
LY
Sun
Di
D
Fang
Kai
K
Zhao
Yan-Yan
YY
D005260:Female; D020022:Genetic Predisposition to Disease; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D020962:Heterotrimeric GTP-Binding Proteins