title: Death and anti-death: tumour resistance to apoptosis.
abstract: Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells often have faulty apoptotic pathways. These defects not only increase tumour mass, but also render the tumour resistant to therapy. So, what are the molecular mechanisms of tumour resistance to apoptosis and how can we use this knowledge to resensitize tumour cells to cancer therapy?
authors: Tumor Immunology Program, German Cancer Research Center (DKFZ), Heidelberg.
authors: Frederik H
authors: FH
authors: Igney
authors: Peter H
authors: PH
authors: Krammer
mesh_terms: D000818:Animals; D017209:Apoptosis; D015536:Down-Regulation; D006801:Humans; D008024:Ligands; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D008024:Ligands; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53