title: The HERV-W/7q family in the human genome. Potential for protein expression and gene regulation.
abstract: A new family of human endogenous retroviruses has recently been discovered. The best known example of a full length member of this family, HERV-W/7q, is located on chromosome 7. HERV-W/7q is characterized by a long open reading frame within its env gene which is expressed in various tissues, and mainly in placenta, as a protein that we called enverin. A search for new retroviral sequences related to the HERV-W/7q family allowed the characterization of such elements in chromosome 6. A novel full length HERV with an env gene of the HERV-W/7q type, potentially encoding a truncated form of enverin has been identified on chromosome 10. The distribution of HERV-W/7q related sequences close to or within genes offers the possibility that the expression of these genes may be regulated by their companion retroviral sequences.
authors: INSERM U-488, Bâtiment Gregory Pincus, Le Kremlin-Bicêtre, France. alliel@kb.inserm.fr
authors: Patrick M
authors: PM
authors: Alliel
authors: Jean-Pierre
authors: JP
authors: Périn
authors: Danièle
authors: D
authors: Goudou
authors: Marc
authors: M
authors: Bitoun
authors: Brigitte
authors: B
authors: Robert
authors: François
authors: F
authors: Rieger
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D020077:Endogenous Retroviruses / Q000235:genetics*; D015686:Gene Products, env / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D015686:Gene Products, env