Parvalbumin positive dendrites co-localize with apical dendritic bundles in rat retrosplenial cortex.
The granular retrosplenial cortex in rats, involved in learning and memory, has a highly modular organization in layer 1. Apical dendrites of layer 2 pyramidal neurons form bundles, which correspond to patchy thalamic input. Here, we demonstrate that dendrites of parvalbumin-immunoreactive (PV-ir) GABAergic neurons in layers 2/3 also form bundles, and that these co-localize in layer 1 with the apical dendritic bundles, as verified by double immunofluorescence for PV and microtuble-associated protein. Deeper, at the border of layers 1/2, the PV-ir bundles merge into a honeycomb-like structure, with walls consisting of PV-ir neuropil. Compartmentalization in layers 1/2 is characteristic of other periallocortical structures. Further work is necessary to determine whether these specializations may be specifically related to learning and memory.
Ichinohe
Noritaka
N
Lab for Cortical Organization and Systematics, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Rockland
Kathleen S
KS
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D003712:Dendrites / Q000378:metabolism* / Q000648:ultrastructure; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006179:Gyrus Cinguli / Q000166:cytology / Q000378:metabolism*; D007395:Interneurons / Q000166:cytology / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000166:cytology; D010320:Parvalbumins / Q000378:metabolism*; D017966:Pyramidal Cells / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D016708:Synaptophysin / Q000378:metabolism; D013788:Thalamus / Q000166:cytology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D007527:Isoenzymes; D008869:Microtubule-Associated Proteins; D010320:Parvalbumins; D016708:Synaptophysin; D005680:gamma-Aminobutyric Acid; D000110:Acetylcholinesterase; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2