[Cytomegalovirus infection associated with plasma endothelin and P-selectin in patients with essential hypertension].
BACKGROUND
To investigate the relationship between human cytomegalovirus (HCMV) infection and plasma endothelin and P-selectin in patients with essential hypertension.


METHODS
Blood samples of 98 patients with essential hypertension were collected for HCMV IgM and IgG antibodies, plasma endothelin and plasma P-selectin by chemiluminescence technique, radio-immunoassay and ELISA.


RESULTS
The rates of positive HCMV IgM antibodies and positive rates for both HCMV IgM and IgG antibodies were 56.12% and 54.08%, respectively, which were higher than that of the control group (P=0.05). The level of plasma endothelin and P-selectin in patients with positive HCMV IgM antibodies was 95.53 +/- 5.06 ng/ml and 42.50 +/- 3.28 ng/ml, respectively, which were higher than that in patients with negative HCMV IgM antibodies (71.60 +/- 4.34 ng/ml and 27.41 +/- 5.28 ng/ml) and that of the control group (48.77 +/- 5.96 ng/ml and 19.80 +/- 4.62 ng/ml).


CONCLUSIONS
These results suggest that HCMV active infection may aggravate vascular endothelium lesi on in patients with essential hypertension and contribute to the increase of endothelin and P-selectin.
Feng
T
T
Department of Medicine, Yuhang First Peoples Hospital, Hangzhou 311100, China.
Yuan
H
H
D000328:Adult; D000368:Aged; D003586:Cytomegalovirus Infections / Q000097:blood / Q000150:complications*; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*
D016232:Endothelins; D019007:P-Selectin