title: Electrophysiological evidence reveals affective evaluation deficits early in stimulus processing in patients with panic disorder.
abstract: Cognitive and neurobiological accounts of clinical anxiety and depression were examined via event-related brain potentials (ERPs) recorded from patients with panic disorder and healthy controls as they performed an old/new recognition memory task with emotionally negative and neutral words. The emotive connotation of words systematically influenced control subjects' - but not patients' - ERP effects at prefrontal sites in a latency range (to approximately 300-500 ms) generally assumed to reflect greater contribution of automatic than controlled memory processes. This provides evidence for dysfunctional inhibitory modulation of affective information processing in panic disorder. The ERP effects after 700 ms, however, suggest that some patients may adopt conscious strategies to minimize the impact of these early processing abnormalities on overt behaviors.
authors: Department of Cognitive Science, University of California, San Diego, USA. Sabine.Windmann@ruhr-uni-bochum.de
authors: Sabine
authors: S
authors: Windmann
authors: Zoha
authors: Z
authors: Sakhavat
authors: Marta
authors: M
authors: Kutas
mesh_terms: D000293:Adolescent; D000328:Adult; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D016584:Panic Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D017397:Prefrontal Cortex / Q000503:physiopathology; D014706:Verbal Learning / Q000502:physiology*