title: Postural ataxia at high altitude is not related to mild to moderate acute mountain sickness.
abstract: To evaluate the role of acute mountain sickness (AMS) in the pathogenesis of stance abnormalities occurring at high altitude, static posturography was applied to 22 healthy subjects at an altitude of 450 m and during a 3-day sojourn at 4559 m. Subjects stood on a platform and sway velocity (S), and sway velocity in the antero-posterior (S(AP)) and medio-lateral (S(ML)) directions was recorded for 20 s with eyes open (EO) and 20 s with eyes closed (EC). Arterialized blood from an ear lobe was analyzed to determine the arterial partial pressures of oxygen (PaO2) and carbon dioxide, and oxygen saturation (SaO2). AMS was assessed by the environmental symptom questionnaire (ESQ) of Sampson (cerebral AMS, AMS-C score > 0.7). AMS affected four subjects on day 1, ten subjects on day 2, and five subjects on day 3. Posturographic findings showed no difference between subjects with AMS and healthy subjects, and no correlation with the ESQ score. PaO2 and SaO2 showed non-significant trends toward lower values in subjects with AMS than in those without AMS. Posturographic parameters significantly worsened on the 1st (EO-S, P < 0.001; EC-S, P < 0.01; EO-SML, P < 0.05), 2nd (EO-S, EC-S and EO-SML, P < 0.01) and 3rd days (EC-S, P < 0.05) at high compared to low altitude. Differences in AMS-C score, SaO2 and PaO2 were significant between low and high altitude (P < 0.0001). Our data suggest that AMS is not important in the pathogenesis of postural ataxia occurring at high altitude.
authors: Department of Neurology, University Hospital, Zürich, Switzerland. ralf.baumgartner@nos.usz.ch
authors: Ralf Werner
authors: RW
authors: Baumgartner
authors: Urs
authors: U
authors: Eichenberger
authors: Peter
authors: P
authors: Bärtsch
mesh_terms: D000328:Adult; D000531:Altitude; D000532:Altitude Sickness / Q000150:complications* / Q000503:physiopathology*; D001259:Ataxia / Q000209:etiology* / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011187:Posture / Q000502:physiology*
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen