Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome.
Two cases of reversible posterior leukoencephalopathy syndrome were examined with proton MR spectroscopic imaging. Widespread metabolic abnormalities, consisting of increased choline and creatine levels and mildly decreased N-acetylaspartate, occurred in regions with both normal and abnormal MR imaging appearances. In one case for which proton MR spectroscopic imaging follow-up was available, all metabolite levels had returned to normal by 2 months. Proton MR spectroscopic imaging may be helpful for the diagnosis and investigation of the underlying pathophysiology of reversible posterior leukoencephalopathy syndrome.
Eichler
Florian S
FS
Department of Neurogenetics, The Johns Hopkins University, Baltimore, MD, USA.
Wang
Paul
P
Wityk
Robert J
RJ
Beauchamp
Norman J
NJ
Barker
Peter B
PB
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001927:Brain Diseases / Q000175:diagnosis / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D003221:Confusion / Q000175:diagnosis / Q000378:metabolism*; D003401:Creatine / Q000378:metabolism; D005260:Female; D006261:Headache / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000378:metabolism; D012640:Seizures / Q000175:diagnosis / Q000378:metabolism*; D013577:Syndrome; D014018:Tissue Distribution; D014786:Vision Disorders / Q000175:diagnosis / Q000378:metabolism*
D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline