title: Serum lactate dehydrogenase isoenzyme 1 in patients with seminoma stage I followed with surveillance.
abstract: Serum lactate dehydrogenase isoenzyme I catalytic concentration (S-LD-1) was measured in patients with testicular seminoma clinical stage I followed with surveillance after orchiectomy. The serum samples were obtained before orchiectomy in 110 patients (group A) and soon after orchiectomy in 55 patients (group B). In group A, 60 patients (55%) had elevated S-LD-1 and 10 patients (9%) had elevated serum human chorionic gonadotropin concentrations (S-hCG). In group B, median S-LD-1 was lower than that of group A and decreased with increasing time after orchiectomv (p = 0.001, Jonckheere-Terpstra test, one-sided). After a median follow-up of 5.1 years, 23 patients (21%) in group A had relapses. The patients with elevated S-LD-1 and those with normal S-LD-1 had a similar relapse-free survival (p = 0.79, log-rank test). Thus patients with seminoma stage I had elevated S-LD-1 more often than elevated S-hCG but an elevation in S-LD-1 did not predict a relapse during follow-up with surveillance. Further studies are required to elucidate the value of S-LD-1 in monitoring the surveillance of patients with seminoma stage I.
authors: Department of Clinical Chemistry Odense University Hospital, Denmark. feve@post5.tele.dk
authors: Finn Edler
authors: FE
authors: von Eyben
authors: Ebbe Lindegaard
authors: EL
authors: Madsen
authors: Ole
authors: O
authors: Blaabjerg
authors: Per Hyltoft
authors: PH
authors: Petersen
authors: Grete Krag
authors: GK
authors: Jacobsen
authors: Lena
authors: L
authors: Specht
authors: Bent Nørgaard
authors: BN
authors: Pedersen
authors: Hans
authors: H
authors: von der Maase
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000201:enzymology / Q000473:pathology / Q000601:surgery; D006063:Chorionic Gonadotropin / Q000097:blood; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000201:enzymology; D009367:Neoplasm Staging; D009919:Orchiectomy / Q000379:methods*; D011300:Preoperative Care; D018239:Seminoma / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D013090:Spermatocytes / Q000201:enzymology / Q000473:pathology; D015996:Survival Rate; D013736:Testicular Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D006063:Chorionic Gonadotropin; D007527:Isoenzymes; D000509:alpha-Fetoproteins; D007770:L-Lactate Dehydrogenase; C409667:lactate dehydrogenase 1