Brain metastases in Wilms' tumor: case report and literature review.
A 2-year-old girl who had a stage 2, favorable-histology Wilms tumor diagnosed when she was age 10 months presented with multiple brain metastases at second recurrence. She had been treated with combined radiotherapy, surgery, and chemotherapy; at 2 months after treatment, recurrent disease developed in the central nervous system and she died. Brain metastases are rare in the natural history of Wilms tumor. Although it does not appear that cerebral metastases are a barrier to tumor eradication and long-term survival if treated with combined modality therapy, treatment should be individualized.
MacRae
Rob
R
Ottawa Regional Cancer Center and the Children's Hospital of Eastern Ontario, Canada.
Grimard
Laval
L
Hsu
Elizabeth
E
Nizalik
Elizabeth
E
Halton
Jacqueline M
JM
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D016190:Carboplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003399:Craniotomy; D017809:Fatal Outcome; D005260:Female; D005625:Frontal Lobe; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007223:Infant; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000601:surgery; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009392:Nephrectomy; D009778:Occipital Lobe; D010166:Palliative Care; D010291:Paresis / Q000209:etiology; D010296:Parietal Lobe; D013908:Thoracotomy; D009396:Wilms Tumor / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery
D016190:Carboplatin; D007069:Ifosfamide