Poly(D,L-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly (D,L-lactic acid-co-glycolic acid) triblock copolymer and thermoreversible phase transition in water.
Novel thermoreversible gelation behavior of aqueous solutions of ABA-type triblock copolymers composed of the central polyethylene oxide (PEG) block and two poly(D,L-lactic acid-co-glycolic acid) side blocks was found. Phase transition characteristics, such as critical gel concentration (CGC) and lower and upper critical gel temperature (CGT), are closely related to the molecular structure of the triblock copolymers. The CGC and the lower CGT both increases with increasing PEG/PLGA molecular weight ratio. Increasing the GA content in PLGA block induces a somewhat higher CGC. The copolymer forms micelles with a PLGA loop core and a PEG shell in water. Also grouped micelles are identified seemingly due to the bridging of two micelles sharing two PLGA blocks of a block copolymer chain. As the temperature increases the association of micelles increases, which results in gelation. The ABA-type copolymers exhibit a relatively low CGC (<10%) and low sol-gel transition temperatures compared to BAB-type copolymers. As the temperature increases further gel-sol transition is observed, which would result from the shrinkage of micelles with temperature increase. The hydrodynamic size of the micelles is monitored by dynamic laser scattering, and a possible gelation mechanism was suggested.
Shim
Myung Seob
MS
Center for Advanced Functional Polymers, Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Kyungki 440-746, Korea.
Lee
Hyung Tak
HT
Shim
Woo Sun
WS
Park
Insun
I
Lee
Hyunjung
H
Chang
Taihyun
T
Kim
Sung Wan
SW
Lee
Doo Sung
DS
D005782:Gels / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D007834:Lasers; D012542:Scattering, Radiation; D012995:Solubility; D013696:Temperature; D014867:Water
D005782:Gels; D020100:Hydrogels; D014867:Water