title: Potency, sterility and immunogenicity of rabies tissue culture vaccine after reconstitution and refrigerated storage for 1 week.
abstract: The economical Thai Red Cross intradermal (TRC-ID) post-exposure rabies treatment schedule is now widely used in Asia. However, directives from WHO and manufacturers mandated that the vaccine be used within 8h after reconstitution of the freeze-dried product. This limits the use of TRC-ID to large animal bite clinics that see several rabies exposed patients daily. This study demonstrated that refrigerated purified chick embryo and Vero cell rabies vaccines can be stored safely for up to 7 days after reconstitution; allowing use of this treatment regimen in clinics that see few rabies exposed subjects. A large project applying this method in a Northern Thai canine rabies endemic province is now in place.
authors: Queen Saovabha Memorial Institute, Thai Red Cross Society and Department of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand.
authors: Pakamatz
authors: P
authors: Khawplod
authors: Henry
authors: H
authors: Wilde
authors: Tanpetch
authors: T
authors: Tantawichien
authors: Sukulya
authors: S
authors: Limusanno
authors: Teerapong
authors: T
authors: Tantawichien
authors: Channarong
authors: C
authors: Mitmoonpitak
authors: Apinya
authors: A
authors: Saikasem
authors: Somsri
authors: S
authors: Raksakert
mesh_terms: D000818:Animals; D002642:Chick Embryo; D002522:Chlorocebus aethiops; D046508:Culture Techniques; D004356:Drug Storage; D006805:Human Experimentation; D006801:Humans; D011817:Rabbits; D011818:Rabies / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000276:immunology / Q000592:standards*; D013242:Sterilization / Q000379:methods; D014709:Vero Cells
chemical_list: D011819:Rabies Vaccines