title: Both transferrin binding proteins are virulence factors in Actinobacillus pleuropneumoniae serotype 7 infection.
abstract: Three genetically defined Actinobacillus pleuropneumoniae serotype 7 mutants with deletions in the small (tbpB), the large (tbpA), and both transferrin binding protein genes were constructed and examined in an aerosol infection model. Neither mutant caused clinical disease or could be reisolated, and no immune response could be detected 21 days after infection. This result clearly implies that each transferrin binding protein on its own is a virulence factor of A. pleuropneumoniae serotype 7.
authors: Institut für Mikrobiologie und Tierseuchen, Tieraerztliche Hochschule Hannover, Bischofsholer Damm 15, 30173, Germany.
authors: Nina
authors: N
authors: Baltes
authors: Isabel
authors: I
authors: Hennig-Pauka
authors: Gerald-F
authors: GF
authors: Gerlach
mesh_terms: D000189:Actinobacillus Infections / Q000382:microbiology* / Q000662:veterinary*; D016977:Actinobacillus pleuropneumoniae / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D000336:Aerosols; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D017353:Gene Deletion; D033862:Iron-Binding Proteins; D012703:Serotyping; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D033863:Transferrin-Binding Proteins; D014774:Virulence
chemical_list: D000336:Aerosols; D002352:Carrier Proteins; D033862:Iron-Binding Proteins; D033863:Transferrin-Binding Proteins