title: Chlamydia pneumoniae infection and nonspecific aortoarteritis: search for a link with a nonatherosclerotic inflammatory arterial disease.
abstract: BACKGROUND
  The association between Chlamydia pneumoniae infection and atherosclerosis has gained recognition. However, the nature of this association is controversial. The infective link may not be specific for atherosclerosis and may also exist in other nonatherosclerotic arterial diseases. We investigated patients with nonspecific aortoarteritis for serological evidence of prior Chlamydia pneumoniae infection.
  
  
  RESULTS
  Fifty patients each of nonspecific aortoarteritis and coronary artery disease with angiographic evidence of significant (>70%) coronary artery lesions were tested for the presence of IgG antibodies against Chlamydia pneumoniae by micro-immunofluorescence assay and compared with 50 age- and sex-matched normal healthy controls. The number of patients with nonspecific aortoarteritis who tested positive for Chlamydia pneumoniae antibodies (IgG) was not significantly different from controls (8 v. 7, p=ns). The mean titer amongst positive subjects in the two groups was also similar (1:40+/-40 v. 1:50+/-25; p=ns). Patients with coronary artery disease were significantly older than patients with nonspecific aortoarteritis and controls (53.2+/-5.8 v. 21.2+/-9.9 years and 24.5+/-5.2 years, p<0.01 for both) and showed a higher seroprevalence of prior Chlamydia pneumoniae infection (18 v. 8 and 7, p < 0.05 for both). The mean IgG titers of patients with coronary artery disease who tested positive were also significantly higher than the other two groups (1:98+/-34 v. 1:40+/-40, p<0.001 and 1:98+/-34 v. 1:50+/-25, p<0.01, respectively).
  
  
  CONCLUSIONS
  In patients with nonspecific aortoarteritis, the seroprevalence of prior Chlamydia pneumnoniae infection is not more than that in healthy individuals of the same age group, but is significantly lesser than that in patients with coronary artery disease. Thus Chlamydia pneumoniae infection may not be associated with all forms of chronic inflammatory arterial lesions.
authors: Department of Cardiology, Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi. vkbahl@satyam.net.in
authors: V K
authors: VK
authors: Bahl
authors: Partho P
authors: PP
authors: Sengupta
authors: Geeta
authors: G
authors: Sathpathy
authors: Anjana
authors: A
authors: Sharma
authors: Rajeev
authors: R
authors: Narang
authors: Sanjiv
authors: S
authors: Sharma
authors: Subhash C
authors: SC
authors: Manchanda
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000276:immunology; D001025:Aortitis / Q000382:microbiology*; D001161:Arteriosclerosis / Q000382:microbiology; D001167:Arteritis / Q000382:microbiology*; D002648:Child; D023521:Chlamydophila Infections; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D003324:Coronary Artery Disease / Q000382:microbiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G