Experimental approaches to therapy and prophylaxis for heat stress and heatstroke.
New developments in the fields of biochemistry, physiology, sepsis, cancer therapy, and molecular genetics have led to opportunities for the development of new therapies and prophylaxes for heat illnesses and for improving human performance during conditions of environmental stress. These include antilipopolysaccharide agents, anticytokines, potassium channel agents, a diet rich in omega-3 fatty acids, and psychological conditioning. This review summarizes the backgrounds and recent findings in the above fields and provides specific suggestions for potential therapy and prophylaxis for classic and exertional heatstroke and for improving athletic performance.
Gaffin
S L
SL
Environmental Pathophysiology Directorate, US Army Research Institute for Environmental Medicine, Natick, MA 01760-5007, USA.
Hubbard
R
R
D000818:Animals; D017209:Apoptosis; D016207:Cytokines / Q000494:pharmacology; D004195:Disease Models, Animal; D004358:Drug Therapy / Q000639:trends; D004703:Endocrine System / Q000502:physiology; D018882:Heat Stress Disorders / Q000517:prevention & control* / Q000628:therapy*; D018883:Heat Stroke / Q000517:prevention & control* / Q000628:therapy*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008070:Lipopolysaccharides / Q000494:pharmacology; D010913:Pituitary-Adrenal System / Q000502:physiology; D011188:Potassium / Q000493:pharmacokinetics / Q000494:pharmacology*; D013552:Swine
D016207:Cytokines; D008070:Lipopolysaccharides; D011188:Potassium