title: Antifungal properties of 5-hydroxytryptamine (serotonin) against Aspergillus spp. in vitro.
abstract: This study shows that 5-hydroxytrypatmine (5-HT, serotonin) is fungicidal towards conidia and hyphae of clinical isolates of Aspergillus (A.) fumigatus, A. flavus and A. terreus. The minimal fungicidal concentrations for Aspergillus conidia and hyphae ranged between 14.68 to 117.5 mM and 29.37 to 235 mM during 24 and 48 h of incubation. Several serotonin receptor antagonists (5-HT2, 5-HT3) studied in vitro did not influence antifungal activity.
authors: Department of Hygiene and Social Medicine, University of Innsbruck, Austria. Cornelia.Lass-Floerl@uibk.ac.at
authors: Cornelia
authors: C
authors: Lass-Flörl
authors: Barbara
authors: B
authors: Wiedauer
authors: Astrid
authors: A
authors: Mayr
authors: Martin
authors: M
authors: Kirchmair
authors: Ilse
authors: I
authors: Jenewein
authors: Maximilian
authors: M
authors: Ledochowski
authors: Manfred P
authors: MP
authors: Dierich
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D012702:Serotonin Antagonists; D012701:Serotonin