History of haematopoietic stem-cell transplantation.
After fifty years of investigations into the use of pluripotent haematopoietic stem-cell transplantation for cancer therapy, this procedure has progressed from one that was thought to be plagued with insurmountable complications to a standard treatment for many haematological malignancies. How have these hurdles been overcome, and how can the therapy be expanded to include patients who are too old or medically infirm to tolerate conventional transplant approaches?
Little
Marie-Térèse
MT
Transplantation Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
Storb
Rainer
R
D019337:Hematologic Neoplasms / Q000266:history* / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000266:history*; D006412:Hematopoietic Stem Cells / Q000502:physiology; D049673:History, 20th Century; D006801:Humans