The Mre11 complex: at the crossroads of dna repair and checkpoint signalling.
The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode components of this complex result in DNA- damage sensitivity, genomic instability, telomere shortening and aberrant meiosis. The molecular defect that underlies these phenotypes has long been thought to be related to a DNA repair deficiency. However, recent studies have uncovered functions for the Mre11 complex in checkpoint signalling and DNA replication.
D'Amours
Damien
D
Wellcome Trust and Cancer Research, UK Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Jackson
Stephen P
SP
D000818:Animals; D004260:DNA Repair / Q000235:genetics / Q000502:physiology*; D004271:DNA, Fungal / Q000502:physiology; D004268:DNA-Binding Proteins; D003851:Deoxyribonucleases / Q000502:physiology*; D004706:Endodeoxyribonucleases / Q000502:physiology*; D005090:Exodeoxyribonucleases / Q000502:physiology*; D005656:Fungal Proteins / Q000502:physiology*; D018816:Genes, cdc / Q000502:physiology; D006801:Humans; D046911:Macromolecular Substances; D009687:Nuclear Proteins / Q000502:physiology; D010766:Phosphorylation; D012441:Saccharomyces cerevisiae / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D015398:Signal Transduction / Q000502:physiology; D016615:Telomere / Q000502:physiology
D004271:DNA, Fungal; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D046911:Macromolecular Substances; D009687:Nuclear Proteins; C086930:RAD50 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C086929:XRS2 protein, S cerevisiae; D003851:Deoxyribonucleases; D004706:Endodeoxyribonucleases; D005090:Exodeoxyribonucleases; C094191:MRE11 protein, S cerevisiae