title: Giant coronary aneurysms due to Kawasaki disease: a case-control study.
abstract: BACKGROUND
  Epidemiologic features of giant coronary aneurysm due to Kawasaki disease and its risk factors are still not clear.
  
  
  METHODS
  Sixty-six patients with giant coronary aneurysms were reported to a 15th nationwide survey of Kawasaki disease in Japan. With all other patients treated in the same hospital as a control group, odds ratios were calculated for certain potential risk factors.
  
  
  RESULTS
  Infant males aged less than 1 year,neutrophil concentration among leukocyte, late administration of intravenous gammaglobulin (IVGG) therapy and additional administration of IVGGwere considered as risk factors of giant coronary aneurysms due to Kawasaki disease. In univariate analysis, use of IVGG therapy and a large amount of IVGG (2500+ mg/kg)elevated the risk, whereas the relationship disappeared after the adjustment.
  
  
  CONCLUSIONS
  The observation of 66 cases with giant coronary aneurysms due to Kawasaki disease reported to the nationwide survey provides some risk factors and consideration about the aneurysms.
authors: Department of Public Health, Jichi Medical School,Tochigi, Japan. nakamuyk@jichi.ac.jp
authors: Yosikazu
authors: Y
authors: Nakamura
authors: Mayumi
authors: M
authors: Yashiro
authors: Izumi
authors: I
authors: Oki
authors: Shinichi
authors: S
authors: Tanihara
authors: Toshiyuki
authors: T
authors: Ojima
authors: Hiroshi
authors: H
authors: Yanagawa
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000209:etiology*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D016017:Odds Ratio; D012307:Risk Factors
chemical_list: D016756:Immunoglobulins, Intravenous