title: [Successful treatment of invasive pulmonary aspergillosis with G-CSF and M-CSF during long-term bone marrow suppression in hypoplastic leukemia].
abstract: A 52-year-old man was admitted for treatment of hypoplastic leukemia (M 1). After induction chemotherapy with IDR and AraC, the patient developed prolonged febrile neutropenia, and a diagnosis of invasive pulmonary aspergillosis was made. We started administration of AMPH-B and G-CSF, but the patient showed no clinical improvement. M-CSF was added to the regimen, and this led to an increase in the white blood cell count with resolution of pneumonia. It is suggested that administration of M-CSF with antibiotics and G-CSF may be beneficial for treating acute leukemia patients with prolonged febrile neutropenia after intensive chemotherapy.
authors: Second Department of Internal Medicine, Mie University School of Medicine.
authors: Kazuhiro
authors: K
authors: Nishii
authors: Hidetsugu
authors: H
authors: Mitani
authors: Hiroyuki
authors: H
authors: Miyashita
authors: Natsuki
authors: N
authors: Hoshino
authors: Eiji
authors: E
authors: Usui
authors: Miho
authors: M
authors: Sakakura
authors: Hiroyoshi
authors: H
authors: Nishikawa
authors: Naoyuki
authors: N
authors: Katayama
authors: Tohru
authors: T
authors: Kobayashi
authors: Hiroshi
authors: H
authors: Shiku
mesh_terms: D001228:Aspergillosis / Q000209:etiology / Q000628:therapy*; D001853:Bone Marrow / Q000503:physiopathology*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000628:therapy*; D008172:Lung Diseases, Fungal / Q000209:etiology / Q000628:therapy*; D016173:Macrophage Colony-Stimulating Factor / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D016173:Macrophage Colony-Stimulating Factor