Effect of gravity change on the production of thrombopoietic growth factors.
It is reported that the stay in the space develops anemia, thrombocytopenia, and altered function and structure of red blood cell. The mechanism of these abnormalities was not clarified yet. The cloning of the thrombopoietin (TPO), followed by the analysis of TPO and c-mpl (its cellular receptor) knockout mice confirmed its role as the primary regulator of thrombopoiesis. TPO has been shown to stimulate both megakaryocyte colony growth from marrow progenitor cells and the maturation of immature megakaryocyte to form functional platelet. This process includes the massive cytoskeletal rearrangement, such as proplatelet formation and fragmentation of proplatelet. In this study we have focused on the production of thrombopoietic growth factors in mice those were exposed to gravity change by parabolic flight (PF).
Fuse
A
A
Dept. Safty Res on Biologics, Natl. Inst. Infect. Dis.
Aoki
Y
Y
Sato
T
T
Kita
M
M
Yamamoto
T
T
Toriizuka
K
K
Sunohara
M
M
Takeoka
H
H
D000818:Animals; D005260:Female; D018471:Hypergravity; D007378:Interleukins / Q000378:metabolism; D007958:Leukocyte Count; D008533:Megakaryocytes / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D010976:Platelet Count; D017701:Reticulocyte Count; D013026:Space Flight; D013926:Thrombopoietin / Q000378:metabolism*; D014893:Weightlessness
D007378:Interleukins; D013926:Thrombopoietin