Clozapine and full-dose concomitant chemoradiation therapy in a schizophrenic patient with nasopharyngeal cancer.
Clozapine is a neuroleptic drug used in selected schizophrenic patients. Its use is limited because of unpredictable myelotoxicity. The potentially dangerous interaction between cancer treatment and clozapine is virtually unknown. A 37-year-old schizophrenic patient under treatment with clozapine, diagnosed with undifferentiated nasopharyngeal carcinoma, was treated with full-dose cisplatin and concomitant radiotherapy without reporting significant neutropenia. Clozapine may be cautiously administered when full-dose concomitant chemoradiation therapy is required.
Bareggi
Claudia
C
Medical Oncology Unit A, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Palazzi
Mauro
M
Locati
Laura D
LD
Cerrotta
Annamaria
A
Licitral
Lisa
L
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy*; D009503:Neutropenia / Q000139:chemically induced; D011879:Radiotherapy Dosage; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy*
D000970:Antineoplastic Agents; D014150:Antipsychotic Agents; D003024:Clozapine; D002945:Cisplatin