Molecular epidemiology of 3 putative virulence genes for Escherichia coli urinary tract infection-usp, iha, and iroN(E. coli).
This study describes the epidemiological association of 3 putative genes for virulence of uropathogenic Escherichia coli; uropathogenic specific protein (usp), a Vibrio cholerae zot gene homologue; IrgA homologue adhesin (iha), a nonhemagglutinating adhesin; and iroN(E. coli), a catechole siderophore receptor homologue. We compared the relative frequency in urinary tract infection (UTI) isolates (n=508), compared with non-UTI isolates (n=416). iroN(E. coli) occurred 2.1-3.6 times more frequently in UTI isolates than in rectal isolates (P=1.1x10-18 to P=2.7x10-5) and was associated with several uropathogenic virulence genes found on pathogenicity islands. usp occurred more frequently in isolates from patients with pyelonephritis (P=3.6x10-9), in periurethral isolates (P=.001), and in isolates from patients with UTI who were aged 40-65 years (P=.004), when compared with the rectal isolates; iha was not associated with UTI in this study.
Bauer
Richard J
RJ
Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, MI 48109, USA.
Zhang
Lixin
L
Foxman
Betsy
B
Siitonen
Anja
A
Jantunen
Maria E
ME
Saxen
Harri
H
Marrs
Carl F
CF
D000293:Adolescent; D000328:Adult; D000368:Aged; D001426:Bacterial Proteins / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000453:epidemiology*; D029968:Escherichia coli Proteins / Q000235:genetics*; D005260:Female; D005387:Finland / Q000453:epidemiology; D005798:Genes, Bacterial; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D011704:Pyelonephritis / Q000382:microbiology; D011956:Receptors, Cell Surface; D012007:Rectum / Q000382:microbiology; D014552:Urinary Tract Infections / Q000382:microbiology*; D014734:Vibrio cholerae / Q000235:genetics*; D014774:Virulence
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D011956:Receptors, Cell Surface; C446159:USP protein, E coli; C074789:irgA protein, Vibrio cholerae