Serum lactate dehydrogenase isoenzyme 1 in patients with seminoma stage I followed with surveillance.
Serum lactate dehydrogenase isoenzyme I catalytic concentration (S-LD-1) was measured in patients with testicular seminoma clinical stage I followed with surveillance after orchiectomy. The serum samples were obtained before orchiectomy in 110 patients (group A) and soon after orchiectomy in 55 patients (group B). In group A, 60 patients (55%) had elevated S-LD-1 and 10 patients (9%) had elevated serum human chorionic gonadotropin concentrations (S-hCG). In group B, median S-LD-1 was lower than that of group A and decreased with increasing time after orchiectomv (p = 0.001, Jonckheere-Terpstra test, one-sided). After a median follow-up of 5.1 years, 23 patients (21%) in group A had relapses. The patients with elevated S-LD-1 and those with normal S-LD-1 had a similar relapse-free survival (p = 0.79, log-rank test). Thus patients with seminoma stage I had elevated S-LD-1 more often than elevated S-hCG but an elevation in S-LD-1 did not predict a relapse during follow-up with surveillance. Further studies are required to elucidate the value of S-LD-1 in monitoring the surveillance of patients with seminoma stage I.
von Eyben
Finn Edler
FE
Department of Clinical Chemistry Odense University Hospital, Denmark. feve@post5.tele.dk
Madsen
Ebbe Lindegaard
EL
Blaabjerg
Ole
O
Petersen
Per Hyltoft
PH
Jacobsen
Grete Krag
GK
Specht
Lena
L
Pedersen
Bent Nørgaard
BN
von der Maase
Hans
H
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000201:enzymology / Q000473:pathology / Q000601:surgery; D006063:Chorionic Gonadotropin / Q000097:blood; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000201:enzymology; D009367:Neoplasm Staging; D009919:Orchiectomy / Q000379:methods*; D011300:Preoperative Care; D018239:Seminoma / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D013090:Spermatocytes / Q000201:enzymology / Q000473:pathology; D015996:Survival Rate; D013736:Testicular Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D000509:alpha-Fetoproteins / Q000032:analysis
D006063:Chorionic Gonadotropin; D007527:Isoenzymes; D000509:alpha-Fetoproteins; D007770:L-Lactate Dehydrogenase; C409667:lactate dehydrogenase 1