Radical scavenging activities of niacin-related compounds.
We investigated whether niacin-related compounds had radical-scavenging activity by electron spin resonance methods. Many compounds, but not trigonelline, had radical-scavenging activity against hydroxyl radicals. However, for the nitric oxide radical and 1,1-diphenyl-2-picrylhydrazyl radical, only nicotinic acid hydrazide and isonicotinic acid hydrazide had scavenging activities. These results suggest that the moiety of hydrazide might have an important role in scavenging abilities of various radicals.
Ogata
Shin
S
Department of Life Science, Faculty of Bioresources, Mie University, Tsu, Japan.
Takeuchi
Masayo
M
Teradaira
Shin
S
Yamamoto
Naokuni
N
Iwata
Keiko
K
Okumura
Katsuzumi
K
Taguchi
Hiroshi
H
D001713:Biphenyl Compounds; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000737:chemistry*; D005609:Free Radicals; D017665:Hydroxyl Radical / Q000737:chemistry; D009525:Niacin / Q000031:analogs & derivatives* / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry; D016877:Oxidants / Q000737:chemistry; D010851:Picrates / Q000737:chemistry; D017382:Reactive Oxygen Species
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D005609:Free Radicals; D016877:Oxidants; D010851:Picrates; D017382:Reactive Oxygen Species; D009525:Niacin; D009569:Nitric Oxide; D017665:Hydroxyl Radical; C004931:1,1-diphenyl-2-picrylhydrazyl