title: Absolute stereostructures of cell adhesion inhibitors, macrosphelides H and L, from Periconia byssoides OUPS-N133.
abstract: Macrosphelide L has been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai, and the absolute stereostructures of this material and macrosphelide H, previously undetermined, have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques and some chemical transformation. (R)-Methyl 3-p-bromobenzoyloxy-5-oxohexanoate has been synthesized for configurational assignments of macrosphelide H. These macrosphelides inhibited the adhesion of human-leukemia HL-60 cells to HUVEC.
authors: Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan.
authors: Takeshi
authors: T
authors: Yamada
authors: Masashi
authors: M
authors: Iritani
authors: Katsuhiko
authors: K
authors: Minoura
authors: Atsushi
authors: A
authors: Numata
authors: Yuichi
authors: Y
authors: Kobayashi
authors: Yong-Gang
authors: YG
authors: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002448:Cell Adhesion; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D007783:Lactones; C455262:macrosphelide H