title: Enantioselective conjugate addition of diethylzinc to cyclic enones catalyzed by copper complexes of methylene-bridged P-chirogenic diphosphines.
abstract: The copper-catalyzed enantioselective conjugate addition of diethylzinc to 2-cyclohexen-1-one was investigated using (R,R)-bis-(t-butylmethylphosphino)methane (1c) as a chiral ligand. The reaction was carried out at 0 degrees C in THF-toluene as the solvent system and in the presence of 1.2 mol% of CuOTf afforded (S)-3-ethylcyclohexan-1-one with 85% ee.
authors: Department of Chemistry, Faculty of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
authors: Shin'ichi
authors: S
authors: Taira
authors: Karen V L
authors: KV
authors: Crépy
authors: Tsuneo
authors: T
authors: Imamoto