title: Synthesis and cholera toxin binding properties of a lactose-2-aminothiazoline conjugate.
abstract: [structure: see text] During the search for improved monovalent ligands for cholera toxin (CT), a new lactose-2-aminothiazoline conjugate was discovered. In a fluorescence binding assay the compound was found to be one of the strongest relatively simple CT ligands to date with a K(d) of 23 microM.
authors: Department of Medicinal Chemistry, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB, The Netherlands.
authors: Ioannis
authors: I
authors: Vrasidas
authors: Johan
authors: J
authors: Kemmink
authors: Rob M J
authors: RM
authors: Liskamp
authors: Roland J
authors: RJ
authors: Pieters
mesh_terms: D002240:Carbohydrate Sequence; D002772:Cholera Toxin / Q000737:chemistry*; D004187:Disaccharides / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D004187:Disaccharides; D008024:Ligands; D013844:Thiazoles; C458199:lactose-2-aminothiazoline; D002772:Cholera Toxin