Antioxidant effect of T-type calcium channel blockers in gastric injury.
It is known that calcium ion has an important role in the cellular function. For this reason, calcium channel blockers may have a protective action against gastric injury which is induced by various stimuli. In this study, the influence of mibefradil on ethanol-induced gastric injury was investigated in rats. Mibefradil was given at a dose 50 mg/kg intraperitoneally 30 min before administration of 1 ml absolute ethanol given by gavage. We compared this effect of mibefradil with that of omeprazol. Ethanol-induced mucosal damage was evaluated using three different approaches: analysis of biochemical parameters and pathologic and macroscopic investigation. It was found that pretreatment with mibefradil significantly reduced ethanol-induced macroscopic, pathologic, and biochemical changes in the gastric mucosa. In conclusion, it is speculated that this findings may prove important in the development of new and improved therapies for the treatment and prevention of gastric ulcers in humans.
Bilici
Dilek
D
Department of Pharmacology, Medical School, Atatürk University, Erzurum, Turkey.
Banoğlu
Z Nur
ZN
Kiziltunç
Ahmet
A
Avci
Bahattin
B
Ciftçioğlu
Akif
A
Bilici
Sefa
S
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D020747:Calcium Channels, T-Type / Q000187:drug effects*; D000431:Ethanol; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D020748:Mibefradil / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013272:Stomach Diseases / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*
D000975:Antioxidants; D002121:Calcium Channel Blockers; D020747:Calcium Channels, T-Type; D020748:Mibefradil; D000431:Ethanol; D005980:Glutathione Reductase; D005978:Glutathione