title: Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2/PRA.
abstract: Subcutaneous vaccination with recombinant antigen 2/PRA (rAg2/PRA) protected BALB/c mice against intranasal infection with Coccidioides immitis. Subcutaneously vaccinated C57BL/6 mice and intranasally vaccinated BALB/c mice were protected against larger numbers of infecting spores. Weight loss correlated with lethality, but histologic appearance did not. These studies support rAg2/PRA vaccination to prevent coccidioidomycosis.
authors: Valley Fever Center for Excellence, Medicine and Subspecialties Program, Research Program, Southern Arizona Veterans Affairs Health Care System, Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona 85723, USA.
authors: Lisa
authors: L
authors: Shubitz
authors: Tao
authors: T
authors: Peng
authors: Robert
authors: R
authors: Perrill
authors: Julie
authors: J
authors: Simons
authors: Kris
authors: K
authors: Orsborn
authors: John N
authors: JN
authors: Galgiani
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000946:Antigens, Fungal / Q000008:administration & dosage / Q000276:immunology*; D003045:Coccidioides / Q000276:immunology; D003047:Coccidioidomycosis / Q000401:mortality / Q000517:prevention & control*; D004195:Disease Models, Animal; D005260:Female; D005656:Fungal Proteins; D005657:Fungal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006023:Glycoproteins / Q000008:administration & dosage / Q000276:immunology*; D007279:Injections, Subcutaneous; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000382:microbiology / Q000473:pathology; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology*; D015431:Weight Loss
chemical_list: D000946:Antigens, Fungal; D005656:Fungal Proteins; D005657:Fungal Vaccines; D006023:Glycoproteins; D014614:Vaccines, Synthetic; C102758:antigen 2, Coccidioides