Antifungal properties of 5-hydroxytryptamine (serotonin) against Aspergillus spp. in vitro.
This study shows that 5-hydroxytrypatmine (5-HT, serotonin) is fungicidal towards conidia and hyphae of clinical isolates of Aspergillus (A.) fumigatus, A. flavus and A. terreus. The minimal fungicidal concentrations for Aspergillus conidia and hyphae ranged between 14.68 to 117.5 mM and 29.37 to 235 mM during 24 and 48 h of incubation. Several serotonin receptor antagonists (5-HT2, 5-HT3) studied in vitro did not influence antifungal activity.
Lass-Flörl
Cornelia
C
Department of Hygiene and Social Medicine, University of Innsbruck, Austria. Cornelia.Lass-Floerl@uibk.ac.at
Wiedauer
Barbara
B
Mayr
Astrid
A
Kirchmair
Martin
M
Jenewein
Ilse
I
Ledochowski
Maximilian
M
Dierich
Manfred P
MP
D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology
D000935:Antifungal Agents; D012702:Serotonin Antagonists; D012701:Serotonin