title: Arch reconstruction without circulatory arrest: current clinical applications and results of therapy.
abstract: Laboratory and clinical data have confirmed the deleterious effects of deep hypothermic circulatory arrest. Long-term data and rigorous neuropsychiatric data are currently sparse, but that which are available show adverse outcomes following circulatory arrest, and therefore support the use of continuous perfusion techniques. There are no available long-term data on continuous perfusion techniques with respect to neurologic outcomes, but using these techniques the incidence of postoperative seizures or other neurologic events is rare. Currently available bypass systems and microsurgical techniques have allowed continuous flow and regional perfusion to become practical alternatives. Several innovative techniques for avoiding circulatory arrest during neonatal aortic arch reconstruction for univentricular and biventricular hearts are described. It would appear prudent and desirable to provide continuous perfusion now that long-term survival after repair of even the most complex cardiac anomalies including single ventricle defects is commonplace.
authors: Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, CA, USA.
authors: Malcolm J
authors: MJ
authors: MacDonald
authors: Frank L
authors: FL
authors: Hanley
authors: V Mohan
authors: VM
authors: Reddy
mesh_terms: D001013:Aorta, Thoracic / Q000601:surgery*; D002545:Brain Ischemia / Q000517:prevention & control*; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002315:Cardiopulmonary Bypass; D006324:Heart Arrest, Induced; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D007036:Hypothermia, Induced; D011183:Postoperative Complications; D012640:Seizures / Q000209:etiology