title: Preparation and Antibacterial Activity of 3-Methyl-1-p-substituted Phenylpyrazole-5-thiol.
abstract: 3-Methyl-1-phenylpyrazole-5-thiol (3a) and its p-nitro-(5) and p-fluorophenyl (8) derivatives were prepared as potential antimicrobial agents in relatively good yields. Compounds 3a and 8 showed good antibacterial activities against MRSA, S. aureus, S. epidermidis, E. faecalis, E. faecium, and S. pyogenes. Moreover, compound 3a also showed a synergistic effect with some aminoglycosides.
authors: Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
authors: Yoshinobu
authors: Y
authors: Tagawa
authors: Shin'ichi
authors: S
authors: Minami
authors: Toshio
authors: T
authors: Yoshida
authors: Keitaro
authors: K
authors: Tanaka
authors: Shuji
authors: S
authors: Sato
authors: Yoshinobu
authors: Y
authors: Goto
authors: Kenji
authors: K
authors: Yamagata