A mixture of polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and non-ortho polychlorinated biphenyls (PCBs) changed the lipid content of pregnant Long Evans rats.
Pregnant Long Evans rats received 1.0 microg/kg of dioxin toxic equivalents (TEQ) by oral gavage on the 15th gestational day (GD 15), using a dosing mixture that contained two polychlorinated dioxins, four polychlorinated furans and three non-ortho polychlorinated biphenyls (PCBs). Rats were sacrificed on GD 16, GD 21 and postnatal day 4 (PND 4). The lipid content of fetus, pup, placenta and maternal liver, serum and adipose tissue were determined. Treated GD 16 and GD 21 fetuses had identical lipid content to the control group, yet the lipid content of treated pups on PND 4 was 32% higher than that of the control group. On the other hand, the lipid content of placenta, liver, and serum from the treated dams was 44-50%, 24%, and 38% lower than that of the control group, respectively. Thus, a low-dose mixture of dioxin-like compounds can cause changes in lipid content. The lipid content of offspring was not affected until they were exposed via lactation.
Chen
Chia-Yang
CY
Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, 27599-7400, USA. cychen@wadsworth.org
Hamm
Jonathan T
JT
Hass
J Ronald
JR
Albro
Phillip W
PW
Birnbaum
Linda S
LS
D000273:Adipose Tissue / Q000737:chemistry; D000284:Administration, Oral; D000818:Animals; D001572:Benzofurans / Q000009:adverse effects*; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants / Q000009:adverse effects*; D005260:Female; D007774:Lactation; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000737:chemistry; D008431:Maternal-Fetal Exchange; D011078:Polychlorinated Biphenyls / Q000009:adverse effects*; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects* / Q000031:analogs & derivatives*; D011247:Pregnancy; D051381:Rats; D020318:Rats, Long-Evans; D012989:Soil Pollutants / Q000009:adverse effects*
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D008055:Lipids; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants; D011078:Polychlorinated Biphenyls