title: Hepatic volumetry to predict adverse events in percutaneous ablation of hepatocellular carcinoma.
abstract: OBJECTIVE
  This study aimed to clarify the relation of hepatic volumetry to adverse events after percutaneous transhepatic ablation for hepatocellular carcinoma.
  
  
  METHODS
  One hundred and forty-nine patients with hepatocellular carcinoma who underwent percutaneous ablation sessions with complete ablation of cancer nodules, underwent volume measurement of the entire liver, tumor, and ablated area using computed tomography. The parenchymal ablation rate was calculated: (ablated volume-tumor volume)/(entire liver volume-tumor volume) x 100 (%). Other clinical parameters were also analyzed to determine their relationship to adverse events.
  
  
  RESULTS
  The median adjusted liver volume was 591 mL/body surface area (m2) (range: 300 to 1197 mL/m2). The median parenchymal ablation rate was 2.3% (range: 0.2% to 20.2%). Adverse events were observed in 17 patients after percutaneous ablation: liver abscess in 3, hepatic infarction in 3, portal vein thrombus in 3, hemobilia in 1, pleural effusion and/or ascites in 6, and gastric ulcer in 1. Multivariate analysis showed that Child B or C (P = 0.0009), adjusted liver volume < 600 mL/m2 (P = 0.0004), and parenchymal ablation rate > 5% (P = 0.0320) were independent risk factors for adverse events.
  
  
  CONCLUSIONS
  Measurement of liver volume and parenchymal ablation rate are useful to predict the presence of percutaneous ablation-related adverse events.
authors: Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Japan. hoshiday-int@h.u-tokyo.ac.jp
authors: Yujin
authors: Y
authors: Hoshida
authors: Yasushi
authors: Y
authors: Shiratori
authors: Yukihiro
authors: Y
authors: Koike
authors: Shuntaro
authors: S
authors: Obi
authors: Keisuke
authors: K
authors: Hamamura
authors: Takuma
authors: T
authors: Teratani
authors: Shuichiro
authors: S
authors: Shiina
authors: Masao
authors: M
authors: Omata
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed