The acidic ribosomal P proteins.
The acidic ribosomal P proteins (pI 3-4) are unique among ribosomal constituents: the only molecules on the ribosomes existing in multiple copies, they form a hetero-oligomeric complex (P1/P2)(2) recognizable as a lateral protuberance on the 60S ribosomal subunit, which is thought to be directly involved in interactions with elongation factors during the course of protein synthesis. The role of P proteins in translation is still vague; however, they might possess two functional roles-the proteins may increase performance of ribosomes and/or change ribosomal specificity toward different subset of mRNAs. Furthermore, there are also indications that P proteins might be involved in transcription and DNA repair. Also, P proteins are important antigens in autoimmune diseases, infections caused by protozoan parasites, and in molds.
Tchórzewski
Marek
M
Department of Molecular Biology, Institute of Microbiology and Biotechnology, Maria Curie-Sklodowska University, Akademicka Street 19, Lublin, Poland. tchorz@biotop.umcs.lublin.pl
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D015800:Protozoan Proteins; D012269:Ribosomal Proteins / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*
C064601:L12E protein, Trypanosoma cruzi; D015800:Protozoan Proteins; D012269:Ribosomal Proteins