title: Preventing the transfer of Streptococcus mutans from primary molars to permanent first molars using chlorhexidine.
abstract: OBJECTIVE
  The purpose of this study was to determine if the application of 1% chlorhexidine-containing wax on primary molars during the period of eruption of the first permanent molars could prevent the transfer of certain oral flora, namely Streptococcus mutans, to the permanent molars.
  
  
  METHODS
  Fourteen children with a mean age of 6.5 years (7 males and 7 females) were assigned into two groups: a chlorhexidine group (n=9) in which 1% chlorhexidine-containing wax was painted on primary molars on one side of the mouth; and a placebo wax group (n=5) in which a similar wax, but without chlorhexidine, was painted on primary molars on the other side of the mouth. Baseline saliva samples and pooled plaque samples from the primary molars on both sides of the dentition were obtained from the two treatment groups. Following treatment, plaque samples from the occlusal fissures of the first permanent molars on both sides of the dentition were obtained. The levels of S.mutans and other members of the oral flora on the treated sides (chlorhexidine or placebo) were compared with those on the untreated sides.
  
  
  RESULTS
  The results showed that the proportions of S.mutans to S.sanguinis were significantly lower in the chlorhexidine-treated sides compared to the untreated (P=0.04) and in the chlorhexidine-treated patients compared to placebo (P=0.029).
  
  
  CONCLUSIONS
  Since lower mutans to sanguinis ratios have been associated with lower caries experience, treating primary molars with 1% chlorhexidine wax during eruption of permanent first molars may be a simple means for shifting the fissure flora of the permanent molars towards a more favorable balance.
authors: Department of Pediatric Dentistry, University of Michigan, Ann Arbor, USA. sum@umich.edu
authors: Sumer M
authors: SM
authors: Alaki
authors: Walter J
authors: WJ
authors: Loesche
authors: Marcio A
authors: MA
authors: da Fonesca
authors: Robert J
authors: RJ
authors: Feigal
authors: Kathleen
authors: K
authors: Welch
mesh_terms: D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002710:Chlorhexidine / Q000008:administration & dosage / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D003743:Dental Enamel / Q000382:microbiology; D003773:Dental Plaque / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008297:Male; D016555:Matched-Pair Analysis; D008963:Molar / Q000382:microbiology*; D010919:Placebos; D012463:Saliva / Q000382:microbiology; D016037:Single-Blind Method; D013223:Statistics as Topic; D013291:Streptococcus / Q000145:classification / Q000187:drug effects / Q000254:growth & development; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development; D014078:Tooth Eruption; D014094:Tooth, Deciduous / Q000382:microbiology*; D014885:Waxes
chemical_list: D000891:Anti-Infective Agents, Local; D010919:Placebos; D014885:Waxes; D002710:Chlorhexidine