title: Type 1 diabetes: benefits of intensive insulin therapy. Patients should control blood glucose strictly.
abstract: The DCCT randomised trial compared insulin therapy with strict glycaemic control versus less strict insulin therapy in patients with type 1 diabetes. The trial itself lasted more than 6 years, and most of the patients were subsequently followed up for another 4 years. The initial benefit of strict glycaemic control on the onset or worsening of diabetic retinopathy and nephropathy does appear to persist in the long term
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D002986:Clinical Trials as Topic; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin