Hybrid dendritic-linear polyester-ethers for in situ photopolymerization.
Novel first through fourth generation hybrid dendritic-linear copolymers, composed entirely of building blocks known to be biocompatible or degradable to natural metabolites in vivo, are described. Specifically, these copolymers are composed of poly(ethylene glycol), glycerol, and succinic acid and are synthesized using a divergent approach in high yield. A photo-cross-linkable derivative of this copolymer successfully seals 4.1 mm corneal lacerations. The mechanism of tissue repair is likely one of physical entrapment where an interpenetrating network (IPN) is formed between the cross-linked copolymer and the tissue.
Carnahan
Michael A
MA
Department of Chemistry, Duke University and Duke University Medical Center, Durham, North Carolina 27708, USA.
Middleton
Crystan
C
Kim
Jitek
J
Kim
Terry
T
Grinstaff
Mark W
MW
D005131:Eye Injuries / Q000188:drug therapy; D005990:Glycerol / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010777:Photochemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013386:Succinates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D011108:Polymers; D013386:Succinates; C043941:polyglycerol; D011092:Polyethylene Glycols; D005990:Glycerol