title: (3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-perhydro-1,4-oxazine-2,5-dione: an apoptosis-inducer from the fruiting bodies of Isaria japonica.
abstract: (3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione (1) was isolated from the fruiting bodies of Isaria japonica as an apoptosis-inducing agent. The complete structural assignment of the compound was accomplished on the basis of spectroscopic methods and chemical transformations. Compound 1 induced apoptotic cell death of the human leukemia cells (HL-60) in a dose-dependent manner, ranging from 5.0 microg/ml to 100.0 microg/ml.
authors: Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Republic of Korea.
authors: Hyuncheol
authors: H
authors: Oh
authors: Taewan
authors: T
authors: Kim
authors: Gi-Su
authors: GS
authors: Oh
authors: Hyun-Ock
authors: HO
authors: Pae
authors: Kyung-Hwan
authors: KH
authors: Hong
authors: Kyu-Yun
authors: KY
authors: Chai
authors: Tae-Oh
authors: TO
authors: Kwon
authors: Hun-Taeg
authors: HT
authors: Chung
authors: Ho-Sub
authors: HS
authors: Lee
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D001203:Ascomycota; D004305:Dose-Response Relationship, Drug; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009025:Morpholines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012098:Reproduction
chemical_list: C459624:4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione; D009025:Morpholines; C085610:lateritin