The inhibition of pro-inflammatory cytokines with pentoxifylline in the cardiopulmunary bypass lung.
In addition to preventing tissue energy loss during cardiopulmonary bypass, pentoxifylline (Ptx) prevents the production of pro-inflammatory cytokines as well. The aim of this study was to investigate whether Ptx decreases the inflammatory effects of cardiopulmonary bypass on the lungs during open-heart surgery. The patients in the study group (n = 15) who were going through an open-heart surgery had 500 mg l(-1) of Ptx added to their prime solution, whereas the patients in the control group (n = 10) only received prime solution. Pre-pump and post-pump blood samples were obtained from both groups and assayed for interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor alpha (TNFalpha). Lung tissue samples that were obtained after the pump were examined with light microscopy and stained for tissueTNFalpha. Non-parametric Wilcoxon test was utilized for statistical evaluation. In the post-pump period, the difference in the IL-6, IL-8 and TNFalpha levels of the two groups was found to be statistically significant (P<0.005). The tissue samples from the control group had significant staining with TNFalpha. We think that Ptx has important protective effects on the lungs during cardiopulmonary bypass.
Ustünsoy
H
H
Department of Cardiovascular and Thorax Surgery, Gaziantep University School of Medicine, Turkey. hustunsoy@yahoo.com
Sivrikoz
M C
MC
Bakir
K
K
Senkaya
Erbagci
B
B
Uçak
R
R
Nurözler
F
F
D000328:Adult; D002315:Cardiopulmonary Bypass; D016207:Cytokines / Q000037:antagonists & inhibitors*; D004311:Double-Blind Method; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D006325:Heart Atria; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007432:Intraoperative Period; D008168:Lung / Q000187:drug effects* / Q000276:immunology; D008297:Male; D010431:Pentoxifylline / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D016207:Cytokines; D004791:Enzyme Inhibitors; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D010431:Pentoxifylline