Vitamin E supplementation in streptozotocin-treated rats alters cerebellar and plasma nitric oxide metabolism.
Nitric oxide (NO) free radicals appear to contribute to the pathogenesis of a number of disorders including diabetes mellitus. The aim of this study was to determine the effects of streptozotocin (STZ)-induced diabetes on nitric oxide (NO) metabolites in plasma and cerebellar nitric oxide synthase (NOS) activity. Further, it was of interest to determine whether an antioxidant, vitamin E, could reverse the STZ-induced effects. STZ significantly decreased cerebellar NOS but increased the level of plasma total nitrite + nitrate and the level of plasma nitrate. Supplementation with vitamin E effectively reduced the STZ-induced effects. Data demonstrate that vitamin E may serve as a protective antioxidant in STZ-induced diabetes.
Görgün
F Murat
FM
Department of Biochemistry, Cerrahpaşa Medical Faculty, Istanbul University, Turkey. falihmurat@hotmail.com
Gümüştaş
M Koray
MK
Altug
Tuncay
T
Kökoglu
Emine
E
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism*; D019587:Dietary Supplements; D006441:Hemoglobin A / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000097:blood / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D000975:Antioxidants; D001786:Blood Glucose; D014810:Vitamin E; D009569:Nitric Oxide; D006441:Hemoglobin A; D019001:Nitric Oxide Synthase