title: Oncologic and functional results after treatment of giant cell tumors of bone.
abstract: Surgical treatment of giant cell tumor of bone has always been a difficult problem because of its local aggressive behavior. Oncologic results and functional outcome are reported here in a retrospective study of 36 patients, treated by various surgical procedures. The average age at the time of diagnosis was 34 years, and the median follow-up period was 7 years. Twenty-three patients were treated by intralesional excision with local adjuvant therapy, and 11 patients by extralesional excision. Two patients received radiotherapy only. Seven local tumor recurrences (30%) were encountered after intralesional procedures, while local tumor control was the rule after extralesional excision. Intralesional excision with local adjuvant therapy resulted in significantly better functional results compared with extralesional excision. Wide excision was associated with a poor functional outcome and marginal excision with a good functional outcome. For the treatment of giant cell tumor of bone, intralesional excision with local adjuvant therapy is recommended because of a good functional outcome. When applying cryosurgery as the local adjuvant, more vigorous freezing may be necessary to improve local tumor control.
authors: University Medical Center Nijmegen, Department of Orthopaedics, The Netherlands.
authors: Harm W
authors: HW
authors: Boons
authors: Lucien C M
authors: LC
authors: Keijser
authors: H W Bart
authors: HW
authors: Schreuder
authors: Maciej
authors: M
authors: Pruszczynski
authors: J Albert M
authors: JA
authors: Lemmens
authors: René P H
authors: RP
authors: Veth
mesh_terms: D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery*; D002648:Child; D003452:Cryosurgery / Q000379:methods*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005870:Giant Cell Tumors / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019637:Orthopedic Procedures / Q000379:methods*; D020127:Recovery of Function; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome