title: Gender and pramipexole effects on levodopa pharmacokinetics and pharmacodynamics.
abstract: The authors studied the pharmacokinetics of levodopa (LD) with and without pramipexole (PPX) in men and postmenopausal women with PD. Patients on stable dose of carbidopa/LD were randomized to receive escalating doses of placebo or PPX over 7 weeks. LD and PPX pharmacokinetics were performed after a single test dose 25/100 of carbidopa/LD, before initiation of PPX or placebo, at 1.5 mg/d and 4.5 mg/d of PPX or placebo. Compared to men, women had greater LD bioavailability. PPX did not alter LD bioavailability, and PPX pharmacokinetics were equivalent in men and women.
authors: Department of Neurological Science, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612, USA. kkompoli@rush.edu
authors: K
authors: K
authors: Kompoliti
authors: C H
authors: CH
authors: Adler
authors: R
authors: R
authors: Raman
authors: J H
authors: JH
authors: Pincus
authors: M T
authors: MT
authors: Leibowitz
authors: J J
authors: JJ
authors: Ferry
authors: L
authors: L
authors: Blasucci
authors: J N
authors: JN
authors: Caviness
authors: S
authors: S
authors: Leurgans
authors: W M
authors: WM
authors: Chase
authors: L C
authors: LC
authors: Yones
authors: E
authors: E
authors: Tan
authors: P
authors: P
authors: Carvey
authors: C G
authors: CG
authors: Goetz
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D052160:Benzothiazoles; D001682:Biological Availability; D002230:Carbidopa / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000493:pharmacokinetics*; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy*; D017698:Postmenopause; D000077487:Pramipexole; D012737:Sex Factors; D013844:Thiazoles / Q000493:pharmacokinetics*
chemical_list: D000978:Antiparkinson Agents; D052160:Benzothiazoles; D004791:Enzyme Inhibitors; D013844:Thiazoles; D007980:Levodopa; D000077487:Pramipexole; D002230:Carbidopa