title: FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence.
abstract: OBJECTIVE
  Determine the sensitivity and specificity of [F-18]-fluorine-2-deoxy-D-glucose positron emission tomography (FDG-PET) in differentiating non-small cell lung cancer (NSCLC) from benign solitary pulmonary nodules (SPNs) in a region with a high endemic rate of histoplamosis.
  
  
  METHODS
  Prospective, clinical study.
  
  
  METHODS
  University, tertiary referral hospital in the upper Mississippi River valley.
  
  
  METHODS
  Ninety patients with SPNs.
  
  
  METHODS
  Independent interpretation of FDG-PET imaging, computed tomography and pathologic evaluation of the SPNs.
  
  
  RESULTS
  To detect malignant SPNs, FDG-PET imaging had a sensitivity of 93%, a specificity of 40%, a positive predictive value (PPV) of 88% and a negative predictive value (NPV) of 55%.
  
  
  CONCLUSIONS
  In a region with a high prevalence of pulmonary fungal infection, FDG-PET is sensitive but has a low specificity and NPV for identifying NSCLC. In our study cohort, FDG-PET does not appear to reduce the need for SPN biopsies.
authors: The University of Iowa, Iowa City, IA, USA. donitacroft@yahoo.com
authors: Donita R
authors: DR
authors: Croft
authors: John
authors: J
authors: Trapp
authors: Kemp
authors: K
authors: Kernstine
authors: Peter
authors: P
authors: Kirchner
authors: Brian
authors: B
authors: Mullan
authors: Jeffery
authors: J
authors: Galvin
authors: Michael W
authors: MW
authors: Peterson
authors: Thomas
authors: T
authors: Gross
authors: Geoffrey
authors: G
authors: McLennan
authors: Jeffrey A
authors: JA
authors: Kern
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006660:Histoplasmosis / Q000000981:diagnostic imaging / Q000453:epidemiology; D006801:Humans; D007484:Iowa / Q000453:epidemiology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18