A first view of the structure of a type IA topoisomerase with bound DNA.
The first crystal structure of a type IA topoisomerase with bound DNA has been solved. The structure of Escherichia coli topoisomerase III provides key insights regarding the catalytic mechanism and the conformational changes that accompany DNA binding, and enhances our understanding of how topoisomerases control DNA topology in the cell.
Champoux
James J
JJ
Dept of Microbiology, Box 357242, School of Medicine, University of Washington, Seattle, WA 98195, USA. champoux@u.washington.edu
D002384:Catalysis; D004247:DNA / Q000378:metabolism*; D004264:DNA Topoisomerases, Type I / Q000737:chemistry* / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology*; D011487:Protein Conformation
D004247:DNA; D004264:DNA Topoisomerases, Type I