Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets.
BACKGROUND
Tumor markers such as CA130 can be determined in human whole saliva. Saliva represents an attractive body fluid for longitudinal studies.


METHODS
CA130 was determined in parotid saliva from 8 rats fed different diets, with or without autonomic denervation.


RESULTS
CA130 could be determined in parotid saliva of rats, irrespective of diet and/or autonomic denervation. Whether the numerical decrease in CA130 observed after autonomic denervation is statistically significant requires further work.


CONCLUSIONS
Since salivary CA130 has been shown to decrease following treatment with anti-cancer drugs in humans, the ability to determine this tumor marker in rat saliva opens new opportunities for optimizing cancer chronotherapy in the experimental laboratory.
Johnson-Alvares
Dorthea
D
Department of Community Dentistry, Dental School, University of Texas Health Science Center, San Antonio, TX 78284, USA.
Cornélissen
Germaine
G
Portela
Ana
A
Halberg
Erna
E
Rudney
Joel D
JD
Yeh
Chih-Ko
CK
Dodds
Michael
M
Haus
Erhard
E
Schaffer
Erwin
E
Blank
Mikhail
M
Halberg
Franz
F
D000818:Animals; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry / Q000378:metabolism*; D017763:Autonomic Denervation; D014408:Biomarkers, Tumor / Q000276:immunology; D002417:Cattle; D004032:Diet; D006801:Humans; D010306:Parotid Gland / Q000294:innervation / Q000378:metabolism* / Q000601:surgery; D051381:Rats; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*; D013045:Species Specificity
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; C083823:CA-130 antigen