title: Embryonic expression of the leptin receptor gene in mesoderm-derived tissues.
abstract: Leptin acts on the hypothalamus to reduce food intake and on a number of non-neuronal tissues via specific receptors (Lepr). The use of in situ hybridisation to map the Lepr gene in pre-natal mice revealed transcripts in the yolk sac in various structures of the central nervous system and in mesoderm-derived tissues, such as cartilage/bone primordia and musculoaponeurotic laminae. At later stages, significant amounts of Lepr were expressed in the region surrounding the developing eye of the embryo. Lepr was also found to be expressed in the choroid, sclera and connective tissues of the limbus in the adult eye. In conclusion, we have identified new targets for leptin action during embryogenesis and adulthood.
authors: Certo, faculté Necker, 156, rue de Vaugirard, 75015 Paris, France.
authors: Olivier
authors: O
authors: Camand
authors: Sophie
authors: S
authors: Turban
authors: Marc
authors: M
authors: Abitbol
authors: Michèle
authors: M
authors: Guerre-Millo
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000235:genetics; D002356:Cartilage / Q000196:embryology / Q000378:metabolism; D003238:Connective Tissue / Q000196:embryology / Q000378:metabolism; D005123:Eye / Q000254:growth & development / Q000378:metabolism; D005136:Eye Proteins / Q000096:biosynthesis / Q000235:genetics; D005326:Fetal Proteins / Q000096:biosynthesis* / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D005865:Gestational Age; D006413:Hematopoietic System / Q000196:embryology / Q000378:metabolism; D017403:In Situ Hybridization; D020738:Leptin / Q000502:physiology*; D008648:Mesoderm / Q000378:metabolism*; D051379:Mice; D009124:Muscle Proteins / Q000096:biosynthesis / Q000235:genetics; D009130:Muscle, Smooth / Q000196:embryology / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics; D009928:Organ Specificity; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin
chemical_list: D002352:Carrier Proteins; D005136:Eye Proteins; D005326:Fetal Proteins; D020738:Leptin; D009124:Muscle Proteins; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; C515447:leptin receptor, mouse