Primary biliary cirrhosis: seeking the silent partner of autoimmunity.
Primary biliary cirrhosis is a disorder characterised by an intense inflammatory response in the septal and interlobular bile ducts and is considered to be an autoimmune disease. Evidence to suggest that chronic viral infection could be a crucial element in the development of biliary epithelial cell damage and activation of the associated autoimmune response is reviewed
Sutton
I
I
MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK.
Neuberger
J
J
D042942:3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); D000818:Animals; D000906:Antibodies / Q000378:metabolism; D001327:Autoimmune Diseases / Q000150:complications*; D006801:Humans; D007658:Ketone Oxidoreductases / Q000378:metabolism; D008105:Liver Cirrhosis, Biliary / Q000276:immunology* / Q000821:virology; D051379:Mice; D008928:Mitochondria / Q000276:immunology; D009097:Multienzyme Complexes / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D014777:Virus Diseases / Q000150:complications / Q000276:immunology
D000906:Antibodies; D009097:Multienzyme Complexes; D007658:Ketone Oxidoreductases; D042942:3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)