title: Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
abstract: Streptomyces platensis (strain NRRL 18993), a producer of dorrigocins, was shown to produce migrastatin, a cyclic congener of dorrigocin A previously reported from a different organism. Additionally a new compound isomeric to migrastatin, isomigrastatin, was also isolated and its structure was determined to be a cyclic form of dorrigocin B. Both compounds were fully characterized from MS and NMR data. Product titers of both were improved by the addition of XAD-16 resin to the fermentation medium.
authors: Kosan Biosciences, Inc, Hayward, CA 94545, USA.
authors: Elaine J
authors: EJ
authors: Woo
authors: Courtney M
authors: CM
authors: Starks
authors: John R
authors: JR
authors: Carney
authors: Robert
authors: R
authors: Arslanian
authors: Lawrence
authors: L
authors: Cadapan
authors: Stefan
authors: S
authors: Zavala
authors: Peter
authors: P
authors: Licari
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification*; D005285:Fermentation; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D018942:Macrolides; D015394:Molecular Structure; D010881:Piperidones / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000903:Antibiotics, Antineoplastic; D007783:Lactones; D018942:Macrolides; D010881:Piperidones; C455261:isomigrastatin; C418199:migrastatin