Closing in on the biological functions of Fps/Fes and Fer.
Fps/Fes and Fer are the only known members of a distinct subfamily of the non-receptor protein-tyrosine kinase family. Recent studies indicate that these kinases have roles in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell cell interactions. Genetic analysis using transgenic mouse models also implicates these kinases in the regulation of inflammation and innate immunity.
Greer
Peter
P
Division of Cancer Research and Genetics, Queen's University Cancer Research Institute, Kingston, Ontario K7L 3N6, Canada. greerp@post.queensu.ca
D000818:Animals; D005075:Biological Evolution; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D015681:Fusion Proteins, gag-onc / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008954:Models, Biological; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D020239:Receptor Cross-Talk; D017479:Receptors, Platelet-Derived Growth Factor / Q000502:physiology; D015398:Signal Transduction
D015681:Fusion Proteins, gag-onc; D011518:Proto-Oncogene Proteins; C052602:proto-oncogene protein c-fes-fps; D011505:Protein-Tyrosine Kinases; D017479:Receptors, Platelet-Derived Growth Factor; C068415:v-fps oncogene protein, Fujinami sarcoma virus