And now, transcriptomics.
In this issue of Neuron, report different patterns of 5-HT2C pre-mRNA editing in suicide victims, as compared to controls. Treatment of mice with fluoxetine alters the pattern of 5-HT2C transcript editing in the direction opposite that observed for suicide victims. The authors speculate on a possible serotonergic mechanism controlling 5-HT2C pre-mRNA editing.
Garlow
Steven J
SJ
Department of Psychiatry and Behavioral Science, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA.
D000818:Animals; D003863:Depression / Q000235:genetics; D005473:Fluoxetine / Q000494:pharmacology; D006801:Humans; D051379:Mice; D017393:RNA Editing / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000235:genetics* / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D013405:Suicide; D014158:Transcription, Genetic / Q000187:drug effects
D005473:Fluoxetine; D012333:RNA, Messenger; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin; D017367:Selective Serotonin Reuptake Inhibitors