title: Eight new HLA-A alleles associated with antigens in the A2 CREG.
abstract: This report describes eight novel HLA-A alleles. Seven of these new alleles contain substitutions previously reported in other HLA-A alleles, suggesting an origin resulting from a gene conversion mechanism. Of these seven, A*2431 contains a substitution previously associated with a larger polymorphic motif. A*0247 contains a substitution at a previously polymorphic position, but encodes an amino acid change previously unreported in any HLA-A, -B or -C alleles.
authors.affiliation: Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA.
authors.forename: C P
authors.initials: CP
authors.lastname: Gans
authors.forename: D M
authors.initials: DM
authors.lastname: Bradshaw
authors.forename: P F
authors.initials: PF
authors.lastname: Jones
authors.forename: W
authors.initials: W
authors.lastname: Mitton
authors.forename: R
authors.initials: R
authors.lastname: Koester
authors.forename: J
authors.initials: J
authors.lastname: Ng
authors.forename: R J
authors.initials: RJ
authors.lastname: Hartzman
authors.forename: Carolyn K
authors.initials: CK
authors.lastname: Hurley
mesh_terms: D000483:Alleles; D001483:Base Sequence; D003429:Cross Reactions; D005091:Exons; D015234:HLA-A Antigens / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
chemical_list: D015234:HLA-A Antigens