title: Abietane diterpenoids from Coleus xanthanthus.
abstract: Eight new abietane diterpenoids, coleon U 11-acetate (1), 16-acetoxycoleon U 11-acetate (2), and xanthanthusins F-K (3-8), together with five known analogues, coleon U (9), 16-O-acetylcoleon C (10), coleon U-quinone (11), 8alpha,9alpha-epoxycoleon U-quinone (12), and xanthanthusin E (13), were isolated from the aerial parts of Coleus xanthanthus. The structures of 1-8 were elucidated on the basis of spectral methods. Compounds 1, 5, and 11-13 were evaluated for their cytotoxicity against K562 human leukemia cells.
authors.affiliation: Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming 650204, People's Republic of China.
authors.forename: Shuang-Xi
authors.initials: SX
authors.lastname: Mei
authors.forename: Bei
authors.initials: B
authors.lastname: Jiang
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Niu
authors.forename: Ma-Lin
authors.initials: ML
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Na
authors.forename: Zhong-Wen
authors.initials: ZW
authors.lastname: Lin
authors.forename: Chao-Ming
authors.initials: CM
authors.lastname: Li
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006801:Humans; D019686:Lamiaceae / Q000737:chemistry*; D007938:Leukemia; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D013778:Tetrazolium Salts; D013844:Thiazoles; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue