Inverted papilloma of the nasal cavity presenting with massive amounts of squamous metaplastic cells in sputum. A case report.
BACKGROUND
Squamous metaplasic cells are rarely seen in sputum of female nonsmokers.


METHODS
A 47-year-old female nonsmoker presented with massive amounts of squamous metaplasic cells in sputum and an elevated level of squamous cell carcinoma (SCC) antigen in serum present for months, while no causative lesion was detected either by lung computed tomography or bronchoscopy. The patient was eventually diagnosed as having inverted papilloma in the right nasal cavity. Resection of the tumor brought about disappearance of squamous metaplastic cells in sputum and return of serum SCC antigen to the normal range.


CONCLUSIONS
This case clearly demonstrates that squamous metaplastic cells in sputum can originate in lesions in the nasal cavity, although they are rare. It should be kept in mind that the nasal cavity is a potential site producing squamous metaplastic cells in sputum.
Yamazaki
Koichi
K
First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan.
Furuta
Yasushi
Y
Marukawa
Katsuji
K
Moriya
Jun
J
Shimizu
Mikio
M
Arakawa
Mikio
M
Itoh
Tomoo
T
Shimizu
Michio
M
Fukumoto
Shinichi
S
Ogura
Shigeaki
S
Dosaka-Akita
Hirotoshi
H
Nishimura
Masaharu
M
D000951:Antigens, Neoplasm / Q000097:blood; D003581:Cytodiagnosis / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008679:Metaplasia; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology; D009669:Nose Neoplasms / Q000175:diagnosis / Q000473:pathology*; D018308:Papilloma, Inverted / Q000175:diagnosis / Q000473:pathology*; D015843:Serpins; D013183:Sputum / Q000166:cytology*
D000951:Antigens, Neoplasm; D015843:Serpins; C051072:squamous cell carcinoma-related antigen