Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders.
We studied polymorphisms of mitochondrial DNA 5178cytosine/adenine (mt5178C/A) and angiotensin I-converting enzyme (ACE) genes (DCP1) in 127 cerebrovascular disorder (CVD) patients and 294 age-matched normal controls to clarify the genetic background of Japanese patients with CVD. Mt5178C was predominant in CVD patients compared with controls (P<0.01). The frequency of DCP1 insertion (I) and deletion (D) alleles showed no significant difference between the CVD patients and controls or between each CVD subgroup. Although the number of CVD patients in the present study was too small to make a final conclusion, mt5178C might be one of the genetic factors to be considered in Japanese patients with CVD.
Ohkubo
Ryuichi
R
Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, 8-35-1 Sakuragaoka, Kagoshima, Japan.
Nakagawa
Masanori
M
Ikeda
Ken-ichi
K
Kodama
Tomoko
T
Arimura
Kimiyoshi
K
Akiba
Suminori
S
Saito
Minoru
M
Ookatsu
Yosuke
Y
Atsuchi
Yoshihiko
Y
Yamano
Yoshihisa
Y
Osame
Mitsuhiro
M
D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic; D012016:Reference Values; D012307:Risk Factors
D004272:DNA, Mitochondrial; D007703:Peptidyl-Dipeptidase A