title: Sanguinaria-related leukoplakia: epidemiologic and clinicopathologic features of a recently described entity.
abstract: An association between the use of Viadent toothpaste and/or mouthwash and the development of leukoplakia oral mucosal lesions has been described recently. Discontinuing the Viadent products may result in resolution of the leukoplakia, although frequently this is not the case. In order to corroborate the earlier study and to provide further insight regarding the clinical features of this process, a case-control study was conducted. A significant association was seen between the use of Viadent products and the development of oral leukoplakia. Furthermore, leukoplakias affecting sites other than the buccal vestibule also were associated with the use of these products.
authors.affiliation: College of Dentistry, Ohio State University, Columbus, Ohio, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Allen
authors.forename: J
authors.initials: J
authors.lastname: Loudon
authors.forename: A K
authors.initials: AK
authors.lastname: Mascarenhas
mesh_terms: D000470:Alkaloids / Q000009:adverse effects*; D000704:Analysis of Variance; D053119:Benzophenanthridines; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007546:Isoquinolines; D007972:Leukoplakia, Oral / Q000139:chemically induced* / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000009:adverse effects*; D016017:Odds Ratio; D012189:Retrospective Studies; D014100:Toothpastes / Q000009:adverse effects*
chemical_list: D000470:Alkaloids; D053119:Benzophenanthridines; D007546:Isoquinolines; D009067:Mouthwashes; D014100:Toothpastes; C005705:sanguinarine