[Cytotoxic effect of antineoplastic substances and their effect on DNA synthesis and cGMP level in tumor and normal tissues].
The cytostatic effect of antitumour agents line on the level of malignantly changed actively proliferating system (tumour growth) and normal actively proliferating system (splin) was investigated on the basis of DNA synthesis and cGMP rate. Studies of these antitumour agents were carried out on three tumour growth models (Pliss lymphosarcoma, Yablonovskaya glyoblastoma and human glyoblastoma heterografts (subcapsular test). It has been demonstrated that chlofiden, brotheophine, vincristine, adriablastine, natulan, phthorafur have a marked and stable effect of DNA synthesis inhibition, resulting in their marked cytostatic effect and antitumour action stability under the therapy conditions. The experimental data have shown cGMP rates decrease in Pliss lymphosarcoma in the case of high antitumour activity.
Pavlovskaia
G P
GP
Academy of Medical Science of Ukraine, Institute of Pharmacology and Toxicology, Kyiv, Ukraine.
Tanina
S S
SS
Sharykina
N I
NI
Karatsuba
T A
TA
Pus'kov
A N
AN
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006152:Cyclic GMP / Q000378:metabolism*; D004261:DNA Replication / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000378:metabolism*
D000970:Antineoplastic Agents; D006152:Cyclic GMP