[Effects of high fluoride intake on the fluoride of femora, teeth and some biochemical indexes in rats].
In order to approach practicable indexes for assessing the effects of the products which are intended to be used to prevent endemic fluorosis, Wistar rats were fed with fluoridated water(50 mg/L) for four weeks. After only one week treated with fluoride, a higher activity of NAG(N-acetyl-beta-D-glucosaminidase) in urine, ChE(cholinesterase) in blood and increased urinary excretion of fluoride (compared with the control, P < 0.01) were observed, and these changes were lasted to the end of the fourth week of the study, but hydroxyproline in serum and urine had not been changed in both groups. After four weeks, the fluoride levels in the femora and teeth of fluoride treated group were ten times higher than that of the control group. According to the results, fluoride in bones and teeth must be taken as key indexes, the activities of NAG in urine and ChE in blood should be taken into consideration for assessing the effects of fluoride protagonist.
Bai
X
X
Institute of Environmental Health Monitoring, Chinese Academy of Preventive Medicine, Beijing 100021, China.
Shi
Z
Z
Wu
R
R
D000118:Acetylglucosaminidase / Q000652:urine*; D000818:Animals; D002802:Cholinesterases / Q000097:blood*; D005260:Female; D005269:Femur / Q000378:metabolism; D005459:Fluorides / Q000378:metabolism / Q000633:toxicity*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014070:Tooth / Q000378:metabolism*
D002802:Cholinesterases; D000118:Acetylglucosaminidase; D005459:Fluorides