title: Description of a 23.9-kilobase chromosomal deletion containing a region encoding fsr genes which mainly determines the gelatinase-negative phenotype of clinical isolates of Enterococcus faecalis in urine.
abstract: Expression of virulence-related extracellular proteases, gelatinase, and serine protease of Enterococcus faecalis is regulated by a quorum-sensing system encoded by the fsr gene cluster. In this study, a 23.9-kb chromosomal deletion containing the fsr gene cluster region was found to be present in the majority (79%) of gelatinase-negative clinical isolates of E. faecalis from urine.
authors.affiliation: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. nakayama@agr.kyushu-u.ac.jp
authors.forename: Jiro
authors.initials: J
authors.lastname: Nakayama
authors.forename: Reiko
authors.initials: R
authors.lastname: Kariyama
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kumon
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002872:Chromosome Deletion; D002876:Chromosomes, Bacterial; D010450:Endopeptidases / Q000235:genetics; D013293:Enterococcus faecalis / Q000235:genetics* / Q000378:metabolism; D018093:Gelatinases / Q000172:deficiency / Q000378:metabolism*; D006801:Humans; D007783:Lactones; D008970:Molecular Weight; D005810:Multigene Family; D010456:Peptides, Cyclic; D010641:Phenotype; D014556:Urine / Q000382:microbiology*
chemical_list: D001426:Bacterial Proteins; C409031:FsrA protein, Enterococcus faecalis; D007783:Lactones; D010456:Peptides, Cyclic; C438382:gelatinase biosynthesis-activating pheromone; D010450:Endopeptidases; D018093:Gelatinases