[The role of salt regime and modulation of hemorheologic effects of trental in rats with experimental circulatory insufficiency].
Experiments on rats showed that experimental circulatory insufficiency negatively affects the hemorrcological properties. A change in the mineral intake influences some of the hemorreological characteristics. The sodium chloride substitute hyposol (giposol) increased the osmotic resistance reduced the cholesterol level in the erythrocyte membranes On the gyposol background, trental normalized the volume blood flow. Thus, balanced mineral compositions may be a useful additional component in the complex therapy of circulatory insufficiency.
Elenga
A
A
Pharmacology and Clinical Pharmacology Department, Ivanovo State Medical Academy, pr. Engel'sa 8, Ivanovo, 153462 Russia.
Shtrygol'
S Iu
SIu
Nazarov
S B
SB
Kinkembo
N
N
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D004338:Drug Combinations; D004907:Erythrocyte Deformability; D004912:Erythrocytes / Q000737:chemistry; D005121:Extremities / Q000098:blood supply; D006401:Hematologic Agents / Q000494:pharmacology*; D018056:Hemorheology; D007511:Ischemia / Q000097:blood* / Q000503:physiopathology; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008563:Membrane Lipids / Q000097:blood; D009997:Osmotic Pressure; D010431:Pentoxifylline / Q000494:pharmacology*; D011189:Potassium Chloride / Q000008:administration & dosage*; D051381:Rats; D012965:Sodium Chloride / Q000008:administration & dosage*; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*
D004338:Drug Combinations; D006401:Hematologic Agents; C094275:Hyposol; D008563:Membrane Lipids; D017673:Sodium Chloride, Dietary; D012965:Sodium Chloride; D011189:Potassium Chloride; D008278:Magnesium Sulfate; D010431:Pentoxifylline