[Synthesis and application of novel acrylic resin as enteric coating].
The pH sensitive two- and three-component acrylic resins were synthesized by radical solution copolymerization of methyl methacrylate (MMA), methacrylic acid (MAA) and/or butyl acrylate (BA) and their acid values were measured by acid-base titration. The dissolution of naproxen pellets coated with the synthesized resins in dissolution medium of different pH value was studied. The results show that the acrylic resin with different acid value can be prepared by adjusting the monomer ratios (MMA:MAA or MMA:MAA:BA). The smaller the acid value of the resin is, the higher pH sensitive value it has. The release of naproxen from pellets coated with these resins is greatly influenced by the pH value of the dissolution medium and the pH sensitive value of the coating resin. The three-component resins are plastic and can be used as coating material without adding plastisizers.
Guo
S
S
Department of Pharmaceutics, Shanghai Medical University, Shanghai 200032.
Fang
X
X
Huang
H
H
Hu
X
X
D000180:Acrylic Resins / Q000138:chemical synthesis*; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008689:Methacrylates; D009288:Naproxen / Q000032:analysis; D012117:Resins, Synthetic
D000180:Acrylic Resins; D008689:Methacrylates; D012117:Resins, Synthetic; C008384:methacrylic acid; D009288:Naproxen