title: [A case treated successfully with low-dose CDDP and 5-FU for the treatment of liver and para-aortic lymph node metastases and second metastasis to anterior mediastinum lymph nodes from gastric cancer after gastrectomy].
abstract: A 64-year-old-male had recurrent paraaortic lymph node and liver metastases eight months after total gastrectomy and with distal pancreatectomy and splenectomy for advanced gastric cancer. Combined chemotherapy with 5-FU and a low-dose of CDDP was effective and the both lesions disappeared. Thirteen months later, a second recurrence of anterior mediastinum lymph node metastases occurred. After the same protocol, the lesions showed a partial response and lymph node dissection was performed. Histopathological examination showed that the resected lymph nodes had 99% necrosis and fibrotic change. Immunohistochemical examination of p53 of the primary gastric cancer showed negative staining. The patient has been followed for three years after the operation, and has no recurrent lesions.
authors.affiliation: Dept. of Surgery, Sapporo City General Hospital.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Misawa
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Sano
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Sato
authors.forename: Masahiko
authors.initials: M
authors.lastname: Naka
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yumi
authors.initials: Y
authors.lastname: Okawa
authors.forename: Shigeto
authors.initials: S
authors.lastname: Yoneyama
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: Akio
authors.initials: A
authors.lastname: Takada
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use; D001011:Aorta / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum / Q000473:pathology; D008875:Middle Aged; D010180:Pancreatectomy; D013156:Splenectomy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D002945:Cisplatin; D005472:Fluorouracil