Conditioned inhibition of cyclophosphamide-induced taste aversion.
Rats in an experimental group received trials during which 1 flavor (saccharin) was always followed by cyclophosphamide, an immunosuppressive drug, but another (vanilla) was not. An unconditioned stimulus-only group served as a control. Flavor-preference tests revealed that conditioned excitation and conditioned inhibition occurred in the conditioned group subjects but not in the control group subjects. This demonstration suggests that a conditioned inhibitor might be used to modify conditioned and unconditioned immune system functions, for example, natural killer-cell activity.
Lambert
Joseph V
JV
Department of Social Sciences, University of the Sciences in Philadelphia, PA 19104, USA. j.lamber@usip.edu
Whitehouse
Wayne G
WG
D000704:Analysis of Variance; D000818:Animals; D003214:Conditioning, Classical; D003520:Cyclophosphamide; D003863:Depression / Q000276:immunology; D007166:Immunosuppressive Agents; D007266:Inhibition, Psychological; D008297:Male; D011598:Psychoneuroimmunology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric; D013649:Taste
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide