title: Glucose-insulin-potassium solution for acute myocardial infarction.
abstract: OBJECTIVE
  To review the role of glucose-insulin-potassium (GIK) solution in the management of acute myocardial infarction (AMI).
  
  
  METHODS
  MEDLINE (1966-October 2001) database, using the search terms glucose, insulin, potassium, and myocardial infarction.
  
  
  METHODS
  Relevant English-language human studies and meta-analyses.
  
  
  RESULTS
  Most studies that have investigated the use of GIK in AMI have been from the prethrombolytic era. Although most data trended toward favoring GIK in improving mortality and morbidity of AMI, the Polish GIK study was terminated prematurely because of an increase in mortality in patients treated with GIK. Dosage, duration of treatment, and route of administration of GIK varied among studies.
  
  
  CONCLUSIONS
  Until results from larger-scale studies become available, the routine use of GIK infusion in AMI patients is not recommended.
authors.affiliation: Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, New York, NY, USA.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Janiger
authors.forename: Judy W M
authors.initials: JW
authors.lastname: Cheng
mesh_terms: D002986:Clinical Trials as Topic; D000075202:Contraindications; D004338:Drug Combinations; D005947:Glucose / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality; D011188:Potassium / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D007328:Insulin; C030396:glucose-insulin-potassium cardioplegic solution; D005947:Glucose; D011188:Potassium