[Precautions for use and contraindications of thiazolidinediones. A cardiologist opinion].
The European marketing authorization ( product licence ) for thiazolidinediones (rosiglitazone and pioglitazone) contraindicate their use in type 2 diabetic patients with cardiac failure or history of cardiac failure. A warning and special precautions for use apply to fluid retention and cardiac failure. The main experimental and clinical data currently available are reviewed. Guidance are given to prescribing physician for the initiation of thiazolidinediones in type 2 diabetic patients and for management of these patients, particularly those at risk for cardiac failure. The cardiologist advice (and possibly diagnosis by echocardiography) is recommended when clinical doubts exist.
Cohen-Solal
A
A
Service de Cardiologie, Hôpital Beaujon, F - 92110 Clichy, France.
D002309:Cardiology; D002318:Cardiovascular Diseases / Q000150:complications*; D000075202:Contraindications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy; D004452:Echocardiography; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry; D045162:Thiazolidinediones
D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; C089946:2,4-thiazolidinedione