Heterotopic shift of epithelial-mesenchymal interactions in vertebrate jaw evolution.
Genes involved in late specification of the mandibular arch, the source of the vertebrate jaw, are expressed with similar patterns in the oral regions of chick and lamprey embryos. However, morphological comparisons indicate that apparently orthologous homeobox genes were expressed in different subdivisions of the ectomesenchyme in the two species. Therefore, the homology and gene expression of the oral region are uncoupled during the transition from agnathan to gnathostome; we conclude that a heterotopic shift of tissue interaction was involved in the evolution of the jaw.
Shigetani
Yasuyo
Y
Laboratory for Evolutionary Morphology, Center for Developmental Biology, RIKEN, Hyogo 650-0047, Japan.
Sugahara
Fumiaki
F
Kawakami
Yayoi
Y
Murakami
Yasunori
Y
Hirano
Shigeki
S
Kuratani
Shigeru
S
D000818:Animals; D005075:Biological Evolution; D019521:Body Patterning; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000494:pharmacology / Q000502:physiology; D001921:Brain / Q000196:embryology / Q000378:metabolism; D002642:Chick Embryo; D004817:Epidermis / Q000196:embryology / Q000378:metabolism; D004848:Epithelium / Q000196:embryology / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000494:pharmacology / Q000502:physiology; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007568:Jaw / Q000033:anatomy & histology / Q000196:embryology; D007798:Lampreys / Q000196:embryology* / Q000235:genetics; D008046:Lip / Q000196:embryology / Q000378:metabolism; D008334:Mandible / Q000033:anatomy & histology / Q000196:embryology*; D008648:Mesoderm / Q000378:metabolism / Q000502:physiology*; D008969:Molecular Sequence Data; D009055:Mouth / Q000196:embryology / Q000378:metabolism; D009432:Neural Crest / Q000196:embryology / Q000502:physiology; D010802:Phylogeny; D014157:Transcription Factors
D019485:Bone Morphogenetic Proteins; C088334:Distal-less homeobox proteins; D018398:Homeodomain Proteins; D014157:Transcription Factors; D005346:Fibroblast Growth Factors