title: [Primary study of transfusion transmitted virus (TTV) infection in the hepatitis patients and blood donors in Hunan].
abstract: To investigate transfusion transmitted virus (TTV) infection in the hepatitis patients and blood donors in Hunan, we used nested polymerase chain reaction (nPCR) assay with primers from TTV genome to detect TTV DNA in seventy clinical hepatitis cases and forty-three blood donors. The results were as follows: TTV DNA was positive in ten of thirty eight patients with hepatitis B(26.3%), and twelve of thirty-two patients with non-A through non-E(37.5%). Elevated transaminase (ALT) was observed in those cases (452 U.L-1 and 582 U.L-1, respectively). On the other hand, TTV DNA was positive in four of forty-three normal blood donors. The data indicate that infectious rates of TTV in hepatitis patients and blood donors in Hunan are similar to those in Japan, and TTV's pathogenicity needs further study.
authors.affiliation: Liver Research Center, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
authors.forename: Y
authors.initials: Y
authors.lastname: Zheng
authors.forename: X
authors.initials: X
authors.lastname: Zheng
authors.forename: L
authors.initials: L
authors.lastname: Huang
mesh_terms: D001782:Blood Donors; D002681:China; D004266:DNA Virus Infections / Q000635:transmission*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006505:Hepatitis / Q000150:complications*; D006801:Humans; D008297:Male; D022783:Torque teno virus / Q000302:isolation & purification*; D065227:Transfusion Reaction
chemical_list: D004279:DNA, Viral