title: Electrochemical and peroxidase oxidation study of N'-hydroxyguanidine derivatives as NO donors.
abstract: The electrochemical properties of a series of N-substituted-N'-hydroxyguanidines were studied. Two oxidation potentials of each compound were obtained by cyclic voltammetry. The E(ox1) values were from 0.51 to 0.62V, while the E(ox2) values were from 1.14 to 1.81V in acetonitrile solution. Next, their enzymatic controlled NO release abilities were evaluated. All N'-hydroxyguanidines exhibited efficient NO release abilities under the oxidation by horseradish peroxidase in the presence of H(2)O(2).
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
authors.forename: Tingwei
authors.initials: T
authors.lastname: Cai
authors.forename: Ming
authors.initials: M
authors.lastname: Xian
authors.forename: Peng George
authors.initials: PG
authors.lastname: Wang
mesh_terms: D001120:Arginine / Q000737:chemistry; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods; D005609:Free Radicals / Q000737:chemistry; D006146:Guanidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D006735:Horseradish Peroxidase / Q000737:chemistry* / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000737:chemistry; D006898:Hydroxylamines; D007501:Iron / Q000737:chemistry; D009249:NADP / Q000737:chemistry; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry* / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D009573:Nitrites / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D005609:Free Radicals; D006146:Guanidines; D006898:Hydroxylamines; D020030:Nitric Oxide Donors; D009573:Nitrites; C066317:ferryl iron; D009569:Nitric Oxide; D009249:NADP; C029604:hydroxyguanidine; D003577:Cytochrome P-450 Enzyme System; D001120:Arginine; D006861:Hydrogen Peroxide; D007501:Iron; D006735:Horseradish Peroxidase; D019001:Nitric Oxide Synthase