Novel dipeptide macrocycles from 4-oxo, -thio, and -amino-substituted proline derivatives.
Dipeptide macrocycles of type A have been constructed in a versatile manner from the corresponding 4-heteroatom-substituted proline derivatives using an intramolecular Mitsunobu strategy.
Arasappan
Ashok
A
Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. ashok.arasappan@spcorp.com
Chen
Kevin X
KX
Njoroge
F George
FG
Parekh
Tejal N
TN
Girijavallabhan
Viyyoor
V
D003500:Cyclization; D004151:Dipeptides / Q000138:chemical synthesis*; D015195:Drug Design; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry; D053778:Thiazolidines
D004151:Dipeptides; D013844:Thiazoles; D053778:Thiazolidines; C036784:4-ketoproline; D011392:Proline; C003438:thiazolidine-4-carboxylic acid