Yeast and apoptosis.
Even though yeast lack much of the molecular machinery that is responsible for apoptosis in metazoans, they can be a powerful tool in apoptosis research. The ectopic expression of several animal apoptosis proteins in yeast can help us to discover new genes -- and chemical compounds -- that modulate the cell-death pathways of higher eukaryotes.
Jin
Can
C
The Burnham Institute, 10901 N. Torrey Pines Rd, La Jolla, California 92037, USA.
Reed
John C
JC
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D008322:Mammals; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology; D012568:Schizosaccharomyces / Q000235:genetics / Q000502:physiology; D015003:Yeasts / Q000235:genetics / Q000502:physiology*