Combinatorial synthesis of natural products.
Combinatorial syntheses allow production of compound libraries in an expeditious and organized manner immediately applicable for high-throughput screening. Natural products possess a pedigree to justify quality and appreciation in drug discovery and development. Currently, we are seeing a rapid increase in application of natural products in combinatorial chemistry and vice versa. The therapeutic areas of infectious disease and oncology still dominate but many new areas are emerging. Several complex natural products have now been synthesised by solid-phase methods and have created the foundation for preparation of combinatorial libraries. In other examples, natural products or intermediates have served as building blocks or scaffolds in the synthesis of complex natural products, bioactive analogues or designed hybrid molecules. Finally, structural motifs from the biologically active parent molecule have been identified and have served for design of natural product mimicry, which facilitates the creation of combinatorial libraries.
Nielsen
John
J
Department of Chemistry, Building 207, Kemitorvet, Technical University of Denmark, DK-2800 Kgs., Lyngby, Denmark. jni@kemi.dtu.dk
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D001688:Biological Products / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D006877:Hydroxamic Acids / Q000138:chemical synthesis; D010455:Peptides; D014807:Vitamin D / Q000138:chemical synthesis
D000900:Anti-Bacterial Agents; D001688:Biological Products; D006877:Hydroxamic Acids; D010455:Peptides; C067070:trapoxin A; D014807:Vitamin D; C012589:trichostatin A