[Biochemical mechanisms of realization of antiviral and interferon-inducing activity of amixine and its analogs].
Antiviral and interferon inducing activity of the amixine and its some derivatives, as well as their influence on the proteolytic enzymes activity, monooxygenase activity of the microsomal fraction, level of the lipids peroxidation were studied. Lack of correlation between antiviral and interferon inducing activity in the investigated series of compounds was found. Vice versa, the good correlation between interferon inducing activity and the elastase-like activities inhibition ability of the compounds was observed. It allows to state the assumption, that only one ability of compounds to induce of an interferon doesn't suffice for obtaining of high titres of interferon, and while their rather high antiproteolitic activity is necessary. It's shown, that except for one compound the influence of amixine and its derivatives on the red-ox enzymes activity well correlates with their ability to the interferon-inducing. All presented above allows to attribute amixine and its derivatives to polymodal antiviral agents.
Liakhov
S A
SA
Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, Ukraine.
Litvinova
L A
LA
Andronati
S A
SA
Berezina
L K
LK
Galkin
B N
BN
Osetrov
V E
VE
Filippova
T O
TO
Golovenko
N Ia
NIa
D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism / Q000494:pharmacology*; D007369:Interferon Inducers / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D010084:Oxidation-Reduction; D013994:Tilorone / Q000378:metabolism / Q000494:pharmacology*
D000998:Antiviral Agents; D007369:Interferon Inducers; D013994:Tilorone