title: Rice expressing lactoferrin and lysozyme has antibiotic-like properties when fed to chicks.
abstract: Two experiments were conducted to determine whether rice that has been genetically produced to express human lactoferrin (LF) or lysozyme (LZ) protects the intestinal tract similarly to subtherapeutic antibiotics (bacitracin + roxarsone; Antibiotics). Experiment 1 compared 10 corn-soy diets containing 20% of various proportions of LF, LZ or conventional rice (CONV). Chicks fed 5% LF + 10% LZ + 5% CONV had significantly better feed efficiency and thinner lamina propria in the duodenum than those fed 20% CONV. Experiment 2 compared five corn-soy diets containing experimental rice combinations totaling 15% rice. Chicks fed 10% LZ + 5% CONV or 5% LF + 10% LZ had significantly lower feed intake and significantly better feed efficiency than those fed 15% CONV. Chicks fed 10% LZ + 5% CONV, 5% LF + 10% LZ or Antibiotics had significantly greater villous height in the duodenum compared with chicks fed 15% CONV. The lamina propria of the ileum was thinner and contained fewer leukocytes in chicks fed 10% LZ + 5% CONV or Antibiotics compared with those fed 15% CONV. The results from these experiments demonstrate a potential of genetically produced LF and LZ rice to be used as a substitute for antibiotics in broiler diets.
authors.affiliation: Department of Animal Science, University of California-Davis, Davis, CA, USA.
authors.forename: Brooke D
authors.initials: BD
authors.lastname: Humphrey
authors.forename: Ning
authors.initials: N
authors.lastname: Huang
authors.forename: Kirk C
authors.initials: KC
authors.lastname: Klasing
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D002645:Chickens / Q000254:growth & development / Q000378:metabolism*; D004064:Digestive System / Q000187:drug effects* / Q000254:growth & development / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake; D007781:Lactoferrin / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology*; D008297:Male; D009113:Muramidase / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology*; D012275:Oryza / Q000235:genetics* / Q000378:metabolism; D030821:Plants, Genetically Modified / Q000235:genetics / Q000378:metabolism*; D011897:Random Allocation; D015430:Weight Gain
chemical_list: D000890:Anti-Infective Agents; D009113:Muramidase; D007781:Lactoferrin