Influence of insoluble excipients on film coating systems.
Insoluble excipients are added to polymeric film coating solutions and dispersions to improve the physical appearance of dosage forms, enhance the stability of photolytic drugs, and aid in processing. These insoluble additives, however, may significantly affect the physical, mechanical, adhesive, and drug-release properties of the films. In this review, the theories of the interactions between polymer and insoluble excipient are addressed. This article also discusses the influence of the concentration, particle size, morphology, and surface chemistry of insoluble excipients on the various polymer properties.
Felton
Linda A
LA
University of New Mexico, Health Sciences Center, College of Pharmacy, Albuquerque 87131, USA. lfelton@unm.edu
McGinity
James W
JW
D005079:Excipients / Q000737:chemistry*; D010316:Particle Size; D010539:Permeability / Q000187:drug effects; D010860:Pigments, Biological / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012995:Solubility / Q000187:drug effects; D013718:Tensile Strength / Q000187:drug effects
D005079:Excipients; D010860:Pigments, Biological; D011108:Polymers