title: Circumcision in a combined factor V and factor VIII deficiency using desmopressin (DDAVP).
abstract: Combined factor V and VIII deficiency is a rare inherited autosomal recessive single gene disorder commonly seen in the Middle East. Although the factor levels are between 5-30%, several authors have reported that these patients are more prone to bleeding compared to those having an isolated factor deficiency with the same levels. We report an eight-year-old boy with factor V and VIII deficiency who underwent a successful circumcision using desmopressin (DDAVP).
authors.affiliation: Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Devecioğlu
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Eryilmaz
authors.forename: Dicle
authors.initials: D
authors.lastname: Celik
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Unüvar
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Karakaş
authors.forename: Sema
authors.initials: S
authors.lastname: Anak
authors.forename: Leyla
authors.initials: L
authors.lastname: Ağaoğlu
mesh_terms: D002648:Child; D002944:Circumcision, Male / Q000009:adverse effects*; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D005166:Factor V Deficiency / Q000150:complications*; D006467:Hemophilia A / Q000150:complications*; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D037241:Mannose-Binding Lectins; D008565:Membrane Proteins / Q000235:genetics
chemical_list: D006490:Hemostatics; C084004:LMAN1 protein, human; D037241:Mannose-Binding Lectins; D008565:Membrane Proteins; D003894:Deamino Arginine Vasopressin