Urinary albumin excretion and insulin metabolism in clinically healthy 58-year-old men.
The aim of the present cross-sectional study was to investigate the relationship between urinary albumin excretion and insulin sensitivity, intact insulin and insulin propeptides in 104 clinically healthy 58-year-old men recruited from the general population. Insulin sensitivity (hyperinsulinemic euglycemic clamp) adjusted for lean body mass, fasting plasma insulin, proinsulin, split-proinsulin, C-peptide, and urinary albumin excretion and were determined. Urinary albumin excretion was significantly associated with body mass index (BMI), systolic and diastolic blood pressure, plasma insulin, and C-peptide (P <.05). Insulin sensitivity tended to be associated with urinary albumin excretion (P=.07). In a multiple regression analysis, urinary albumin excretion was independently and significantly associated with systolic blood pressure (P <.05). In conclusion, urinary albumin excretion was associated with insulin and C-peptide in clinically healthy 58-year-old men; however, this relationship became insignificant when blood pressure was taken into account in the regression analysis.
Agewall
Stefan
S
Department of Cardiology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Björn
Fagerberg
F
D000419:Albuminuria; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood; D003430:Cross-Sectional Studies; D003971:Diastole; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011384:Proinsulin / Q000097:blood / Q000378:metabolism; D012016:Reference Values; D012044:Regression Analysis; D013548:Sweden / Q000208:ethnology; D013599:Systole
D002096:C-Peptide; D007328:Insulin; D011384:Proinsulin