[PAX-6 gene promoter polymorphism and other factors involved in brain atrophy in alcohol dependent patients].
PAX-6 gene promoter polymorphism, alcohol dependence history and CT were determined in the group of 68 alcoholics. We found negative correlation between numbers of PAX-6 gene promoter B (AC)m (AG)n repeats and atrophy of the brain and the cerebellum. Occurrence of these lesions was correlated with a decrease of alcohol tolerance, withdrawal symptoms--especially delirium tremens.
Samochowiec
Jerzy
J
Katedry i Kliniki Psychiatrii PAM w Szczecinie.
Kucharska-Mazur
Jolanta
J
Horodnicki
Jan
J
Lesch
Klaus Peter
KP
Rommelspacher
Hans
H
Schmidt
Lutz Gerhard
LG
D000328:Adult; D000437:Alcoholism / Q000235:genetics* / Q000473:pathology*; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D005136:Eye Proteins; D005260:Female; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins
D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; C000605730:PAX6 protein, human; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins