[Effect of pentoxyphylline on certain indicators of the proteinase-proteinase inhibitor system in rats upon administration of cycloheximide].
The pentoxifylline influence on neutral proteinase, alpha-2-macroglobulin, trypsin-alpha-1-proteinase inhibitor and elastaseinhibitory activity under cycloheximide injection has been investigated. Two hours after cycloheximide injection the activity of neutral proteinases increases in rats serum, lungs, heart, liver and kidneys. The preliminary injection of pentoxifylline prevents increase of neutral proteinases activity. Cycloheximide also decreases alpha-2-macroglobulin activity in serum and liver and trypsin-, elastaseinhibitory activity of alpha-1-proteinase inhibitor in all investigated organs. At using pentoxifylline the alpha-2-macroglobulin activity doesn't change in liver and increases in serum in comparison with only cycloheximide and there are no observed any alpha-1 inhibitor proteinase activity changes in rats serum and organs.
Samokhin
A A
AA
Karazin Kharkov State University, Ukraine.
Kaliman
P A
PA
Samokhinka
L M
LM
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D010450:Endopeptidases / Q000187:drug effects*; D010431:Pentoxifylline / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000378:metabolism*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D011480:Protease Inhibitors; D011500:Protein Synthesis Inhibitors; D003513:Cycloheximide; D010450:Endopeptidases; D010431:Pentoxifylline