Autoantibodies and HLA susceptibility markers in Canadian first-degree relatives of patients with type 1 diabetes.
We examined the frequencies of autoantibodies to glutamate decarboxylase, GAD65, protein tyrosine phosphatase, IA-2/ICA512, and insulin, and of HLA class II markers in ICA-positive first-degree relatives of patients with type 1 diabetes. Our results indicate that while the presence of HLA susceptibility markers is associated with anti-islet autoantibodies, protective DQB1 markers do not absolutely prevent development of autoantibodies or progression to autoimmune diabetes.
Behme
M T
MT
Robarts Research Institute and Lawson Health Research Institute, London, Ontario, Canada. mbehme@uwo.ca
Mahon
J L
JL
Dupre
J
J
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D002170:Canada; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family
D001323:Autoantibodies; D006680:HLA Antigens