title: [Efficacy and safety of polaprezinc as a preventive drug for radiation-induced stomatitis].
abstract: BACKGROUND
  Radiation-induced stomatitis is one of the adverse effects of total body irradiation(TBI). We examined the usefulness of oral polaprezinc as a preventive drug for stomatitis.
  
  
  METHODS
  The present study was conducted with 19 patients who were diagnosed with hematologic malignancy and who underwent TBI as pretreatment for bone marrow transplantation, peripheral blood stem transplantation, or cord blood stem cell transplantation. Eleven patients ingested the suspension of polaprezinc and 2% carmellose sodium (carboxymethylcellulose sodium: CMC) beginning the day before TBI(P-CMC group), while the other eight patients did not ingest P-CMC(control group). The severity of stomatitis was assessed in each group during a four-weeks period.
  
  
  RESULTS
  Stomatitis (Grade: > or = 3) developed in one of 11 patients in the polaprezinc group and in 4 of 8 patients in the control group(P = 0.046). The times at which stomatitis development ranged between weeks 1 and 2 after the onset of TBI in the two groups. No adverse reaction owing to the ingestion of P-CMC was observed.
  
  
  CONCLUSIONS
  These results suggested the efficacy and safety of polaprezinc as a preventive drug for radiation-induced stomatitis.
authors.affiliation: Department of Radiology, Hyogo College of Medicine.
authors.forename: Fujiwara
authors.initials: F
authors.lastname: Masayuki
authors.forename: Kamikonya
authors.initials: K
authors.lastname: Norihiko
authors.forename: Tsuboi
authors.initials: T
authors.lastname: Keita
authors.forename: Irie
authors.initials: I
authors.lastname: Miwa
authors.forename: Izumi
authors.initials: I
authors.lastname: Masayuki
authors.forename: Irie
authors.initials: I
authors.lastname: Toshihiko
authors.forename: Fujisawa
authors.initials: F
authors.lastname: Hiromi
authors.forename: Muro
authors.initials: M
authors.lastname: Chikaaki
authors.forename: Nakao
authors.initials: N
authors.lastname: Norio
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002336:Carnosine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000517:prevention & control*; D013280:Stomatitis / Q000517:prevention & control*; D014916:Whole-Body Irradiation / Q000009:adverse effects; D017967:Zinc Compounds
chemical_list: D000897:Anti-Ulcer Agents; D009942:Organometallic Compounds; D017967:Zinc Compounds; C061957:polaprezinc; D002336:Carnosine