Structure, properties and in vitro cytotoxic activity of hexakis(2-cyanoethyl)ditin(III).
The structure of the tin(III) complex [Sn(2)(CH(2)CH(2)CN)(6)] has been determined. There are two independent molecules in the crystal, both adopt distorted eclipsed conformation. The molecular and electronic structures of this compound have been studied both at the semiempirical level and with the use of non-empirical ab initio methods. The calculated Sn-Sn distances agree well with those found crystallographically. The results of calculations showed that the eclipsed conformation of complex is more stable as compared with staggered conformation. The compound show modest cytotoxic activity against A549 and HSMC cells.
Pruchnik
Florian P
FP
Faculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wrocław, Poland. pruchnik@wchuwr.chem.uni.wroc.pl
Bańbuła
Małgorzata
M
Ciunik
Zbigniew
Z
Chojnacki
Henryk
H
Skop
Barbara
B
Latocha
Małgorzata
M
Wilczok
Tadeusz
T
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D018360:Crystallography, X-Ray; D004563:Electrochemistry; D006801:Humans; D015394:Molecular Structure; D009947:Organotin Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009947:Organotin Compounds; C460340:hexakis(2-cyanoethyl)ditin(III)