Dysregulation of apoptosis genes in hematopoietic malignancies.
Ever since the discovery of Bcl-2 and the elucidation of its role in apoptosis, tremendous interest has arisen in prospects for triggering suicide of malignant cells by exploiting knowledge emerging from apoptosis research. In this review, we summarize information about the multiple genetic lesions which have been identified in apoptosis-regulatory genes of hematopoietic and lymphoid neoplasms. Emerging data about the structural and biochemical details of apoptosis proteins and their upstream regulators have reveal novel strategies for therapeutic intervention, some of which are under interrogation in clinical trials currently.
Kitada
Shinichi
S
The Burnham Institute, 10901 N. Torrey Pines Rd, La Jolla, California, CA 92037, USA.
Pedersen
Irene M
IM
Schimmer
Aaron D
AD
Reed
John C
JC
D017209:Apoptosis; D002986:Clinical Trials as Topic; D015972:Gene Expression Regulation, Neoplastic; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D014176:Protein Biosynthesis