Corticosteroid-responsive diabetes mellitus associated with autoimmune pancreatitis: pathological examinations of the endocrine and exocrine pancreas.
Histopathological changes of biopsied pancreata were examined in three diabetic patients with autoimmune chronic pancreatitis (ACP). We found intra- and periinsular mononuclear cell (MNC)-mainly CD8+ T cell-infiltration as well as MNC infiltration around the ductal cells. Islet beta cell volume decreased significantly. Some ductal cells expressed insulin and insulin promoter factor-1 concomitantly in the affected pancreas. These findings provide new insight toward understanding the pathological mechanisms of corticosteroid treatment-responsive diabetes associated with ACP.
Tanaka
Shoichiro
S
Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo 105-8470, Japan. s-tanaka@bd5.so-net.ne.jp
Kobayashi
Tetsuro
T
Nakanishi
Koji
K
Okubo
Minoru
M
Odawara
Masato
M
Murase
Toshio
T
Hashimoto
Masaji
M
Watanabe
Goro
G
Matsushita
Hiroshi
H
Inoko
Hidetoshi
H
Takeuchi
Kazuo
K
D000305:Adrenal Cortex Hormones / Q000494:pharmacology* / Q000627:therapeutic use; D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D001706:Biopsy; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000187:drug effects / Q000276:immunology / Q000473:pathology*; D007633:Keratins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*
D000305:Adrenal Cortex Hormones; D006680:HLA Antigens; D007328:Insulin; D007633:Keratins