Effects of moderate and intensive training on the hypothalamo-pituitary-adrenal axis in rats.
The influence of the two distinct training programmes, moderate (M) and intensive (I), on hypothalamo-pituitary-adrenal (HPA) axis was investigated, in rats. Changes in plasma concentrations of adrenocorticotropin hormone (ACTH) and corticosterone were followed in response to (i) a 60-min acute running session performed on 2nd, 4th and 6th of the seven training weeks (ii) an acute restraint stress of 40 min applied after the final training programme. After 2nd, 4th and 6th week of the two training programmes, a 60-min running resulted in an enhanced secretion of ACTH and corticosterone, compared with both the baseline values (i.e. before running) and to the sedentary (S) group. However, on 4th and 6th weeks compared with 2nd week, ACTH and corticosterone remained elevated in intensive group when they are significantly reduced in moderate group. We could suggest that a moderate training resulted in an adapted hormonal response whereas a deadapted process occurred for the intensive programme. The day after the last training session, basal ACTH, corticosterone and corticosteroid-binding globulin (CBG) capacity were not affected by training. Hypothalamic corticotropin-releasing factor tissue-content (CRF) was increased significantly in the two trained groups. When compared with the sedentary group, the body weight of the rats in the two trained groups was significantly decreased with a total adrenal mass increasing but only in intensive group. The surimposed restraint stress resulted in significant increases in plasma ACTH and corticosterone both in trained and in sedentary animals. This result suggests that the adapted HPA axis response induced by both a moderate and intensive training do not prevent against the effects of a novel stress such as restraint stress.
Chennaoui
M
M
Département de Physiologie, IMASSA-CERMA, Brétigny-sur-Orge, France.
Gomez Merino
D
D
Lesage
J
J
Drogou
C
C
Guezennec
C Y
CY
D000311:Adrenal Glands / Q000254:growth & development; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D003345:Corticosterone / Q000097:blood / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000032:analysis; D007030:Hypothalamo-Hypophyseal System / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D009929:Organ Size; D010805:Physical Conditioning, Animal / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000503:physiopathology; D014156:Transcortin / Q000032:analysis
D000324:Adrenocorticotropic Hormone; D014156:Transcortin; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone