Developmental evolution: getting robust about robustness.
In the context of development, a process is robust if it can proceed normally despite the enormous capacity for perturbation inherent in all biological systems. A new mode of theoretical modeling of genetic networks holds great promise for increasing our understanding of both the quantitative mechanisms of robustness and its evolutionary impact.
Gibson
Greg
G
Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, North Carolina 27695-7614, USA. ggibson@unity.ncsu.edu
D000818:Animals; D005075:Biological Evolution; D002454:Cell Differentiation; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis; D008959:Models, Neurological; D009415:Nerve Net / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D011506:Proteins; D012097:Repressor Proteins / Q000378:metabolism; D012641:Selection, Genetic
D011506:Proteins; D012097:Repressor Proteins