Synthesis of 2-alkoxy 1,4-naphthoquinone derivatives as antiplatelet, antiinflammatory, and antiallergic agents.
In our continuing search for novel antiplatelet, antiallergic, and antiinflammatory agents, 2-alkoxy derivatives of 1,4-naphthoquinone were prepared. Some of these compounds showed significant antiplatelet, antiallergic, and antiinflammatory activities. Among them, 2-propoxy-1,4-naphthoquinone and 2-butoxy-1,4-naphthoquinone exhibited potent inhibitory effect on neutrophil superoxide anion formation. These two compounds are worthy of further exploration.
Lien
Jin-Cherng
JC
Graduate Institute of Pharmaceutical Chemistry, China Medical College, Taichung, Taiwan, ROC. jclien@mail.cmc.edu.tw
Huang
Li-Jiau
LJ
Teng
Che-Ming
CM
Wang
Jih-Pyang
JP
Kuo
Sheng-Chu
SC
D018926:Anti-Allergic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects; D015550:Cell Degranulation / Q000187:drug effects; D005966:Glucuronidase / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D008407:Mast Cells / Q000187:drug effects; D009113:Muramidase / Q000378:metabolism; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000648:ultrastructure; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
D018926:Anti-Allergic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D007202:Indicators and Reagents; D009285:Naphthoquinones; D010975:Platelet Aggregation Inhibitors; D013481:Superoxides; D009113:Muramidase; D005966:Glucuronidase