Esophageal basaloid carcinoma with marked myoepithelial differentiation.
A case of esophageal basaloid carcinoma with marked myoepithelial differentiation in a 60-year-old man is reported. The tumor arose as an exophytic mass, measuring 65 x 60 mm, in the middle thoracic esophagus. Approximately two-thirds of the tumor surface was covered with non-cancerous esophageal epithelium. The depth of tumor invasion was limited to the submucosal layer. Histologically, about 70% of the tumor contained a typical basaloid carcinoma component and about 30% contained glandular and intercalated duct-like components with distinct epithelial and myoepithelial differentiation. The tumor presented no component of distinct squamous cell carcinoma, but a small portion of cribriform-like structure, which is typical of adenoid cystic carcinoma, was visible. The inner epithelium composing the intercalated duct-like structure showed immunohistochemical positivity for cytokeratin 14, and the outer epithelium lining adjacent to the stroma showed positivity for alpha-smooth muscle actin. These findings supported epithelial/myoepithelial differentiation. To our knowledge, our case is the first patient with an esophageal basaloid carcinoma showing marked myoepithelial differentiation.
Hishida
Tomoyuki
T
Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan Department of Surgery, National Cancer Center Hospital, Tokyo, Japan.
Nakanishi
Yukihiro
Y
Shimoda
Tadakazu
T
Igaki
Hiroyasu
H
Tachimori
Yuji
Y
Kato
Hoichi
H
Yamaguchi
Hajime
H
Iinuma
Gen
G
D000199:Actins / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D004938:Esophageal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D053547:Keratin-14; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009208:Myoepithelioma / Q000737:chemistry / Q000473:pathology*; D009367:Neoplasm Staging; D016896:Treatment Outcome
D000199:Actins; D014408:Biomarkers, Tumor; C507540:KRT14 protein, human; D053547:Keratin-14; D007633:Keratins