title: Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection.
abstract: Although recent evidence has confirmed the importance of cytotoxic T-lymphocyte (CTL) responses in controlling human immunodeficiency virus type 1 and simian immunodeficiency virus replication, the relevance of the epitopic breadth of those CTL responses remains unexplored. In the present study, we sought to determine whether vaccination can expand CTL populations which recognize a repertoire of viral epitopes that is greater than is typically generated in the course of a viral infection. We demonstrate that potent secondary CTL responses to subdominant epitopes are rapidly generated following a pathogenic simian-human immunodeficiency virus challenge of rhesus monkeys vaccinated with plasmid DNA or recombinant modified vaccinia virus Ankara vaccines. These data indicate that prior vaccination can increase the breadth of the CTL response that evolves after an AIDS virus infection.
authors.affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
authors.forename: Sampa
authors.initials: S
authors.lastname: Santra
authors.forename: Dan H
authors.initials: DH
authors.lastname: Barouch
authors.forename: Marcelo J
authors.initials: MJ
authors.lastname: Kuroda
authors.forename: Jörn E
authors.initials: JE
authors.lastname: Schmitz
authors.forename: Georgia R
authors.initials: GR
authors.lastname: Krivulka
authors.forename: Kristin
authors.initials: K
authors.lastname: Beaudry
authors.forename: Carol I
authors.initials: CI
authors.lastname: Lord
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Lifton
authors.forename: Linda S
authors.initials: LS
authors.lastname: Wyatt
authors.forename: Bernard
authors.initials: B
authors.lastname: Moss
authors.forename: Vanessa M
authors.initials: VM
authors.lastname: Hirsch
authors.forename: Norman L
authors.initials: NL
authors.lastname: Letvin
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D000818:Animals; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control; D015497:HIV-1 / Q000235:genetics / Q000276:immunology; D006801:Humans; D008253:Macaca mulatta; D018449:SAIDS Vaccines / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000517:prevention & control; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014611:Vaccination; D019444:Vaccines, DNA / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D018984:Epitopes, T-Lymphocyte; D018449:SAIDS Vaccines; D019444:Vaccines, DNA