Coagulation proteases and human cancer.
Tumours are capable of activating blood coagulation through the expression of procoagulant molecules such as tissue factor, cancer procoagulant and hepsin. Initiation of the clotting cascade results in the generation of the activated serine proteases factor VIIa, factor Xa and thrombin. These proteases act via protease-activated receptors and tissue factor to alter gene expression, thereby modulating tumour cell growth, invasion, metastasis and angiogenesis.
Sampson
M T
MT
Department of Surgical Oncology and Technology, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, U.K. m.t.sampson_uk@hotmail.com
Kakkar
A K
AK
D001777:Blood Coagulation / Q000235:genetics / Q000502:physiology*; D010450:Endopeptidases / Q000502:physiology*; D016228:Endothelial Growth Factors / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D008074:Lipoproteins / Q000502:physiology; D008222:Lymphokines / Q000502:physiology; D009369:Neoplasms / Q000097:blood* / Q000201:enzymology* / Q000235:genetics; D013925:Thromboplastin / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008074:Lipoproteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; C051928:lipoprotein-associated coagulation inhibitor; D013925:Thromboplastin; D010450:Endopeptidases