Five new iboga alkaloids from Tabernaemontana corymbosa.
Five new indole alkaloids of the ibogan type (1-5), in addition to 12 other known iboga alkaloids, were obtained from the leaf and stem-bark extract of the Malayan species Tabernaemontana corymbosa, viz., 19(S)-hydroxyibogamine (1), 19-epi-isovoacristine (2), isovoacryptine (3), 3R/S-ethoxyheyneanine (4), and 3R/S-ethoxy-19-epi-heyneanine (5). The structures were determined using NMR and MS analysis and comparison with known related compounds.
Kam
Toh-Seok
TS
Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. tskam@kimia.um.edu.my
Sim
Kooi-Mow
KM
D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D008296:Malaysia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D030014:Tabernaemontana / Q000737:chemistry*
D026121:Indole Alkaloids