Abietane diterpenoids from Coleus xanthanthus.
Eight new abietane diterpenoids, coleon U 11-acetate (1), 16-acetoxycoleon U 11-acetate (2), and xanthanthusins F-K (3-8), together with five known analogues, coleon U (9), 16-O-acetylcoleon C (10), coleon U-quinone (11), 8alpha,9alpha-epoxycoleon U-quinone (12), and xanthanthusin E (13), were isolated from the aerial parts of Coleus xanthanthus. The structures of 1-8 were elucidated on the basis of spectral methods. Compounds 1, 5, and 11-13 were evaluated for their cytotoxicity against K562 human leukemia cells.
Mei
Shuang-Xi
SX
Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming 650204, People's Republic of China.
Jiang
Bei
B
Niu
Xue-Mei
XM
Li
Ma-Lin
ML
Yang
Hui
H
Na
Zhi
Z
Lin
Zhong-Wen
ZW
Li
Chao-Ming
CM
Sun
Han-Dong
HD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006801:Humans; D019686:Lamiaceae / Q000737:chemistry*; D007938:Leukemia; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D013778:Tetrazolium Salts; D013844:Thiazoles; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue