[The human alpha(2A)-AR gene and the genotype of site -1296 and the susceptibility to motion sickness].
The gene sequences of alpha(2A)-adrenergic receptor(alpha(2A)-AR) in 39 Chinese and 1 Englishman showed 13 differences of g or c insertion or deletion in its regulation region, coding region and 3' untranslated region, compared with that reported in GenBank. The gene sequences from all the samples respectively were identical except for 2 single nucleotide polymorphisms, including the sequence of sense and antisense strand sequenced. It was found that: (1) the frequency of gg genotype in Chinese and Japanese, who are high susceptible to motion sickness, were 5.8 and 7.8 fold higher than that in Englishmen; (2) g allele frequencies in Chinese and Japanese were higher than latter ( P  0.01 ); (3) gg genotype frequency in population susceptible to motion sickness was 1.6 fold higher than that in population unsusceptible to motion sickness, and g allele frequency was higher than latter ( P  0.01 ). All the populations were in Hardy-Weinberg equilibrium. The results suggested that gg genotype and g allele at site -1296 in alpha(2A)-AR gene could associate with the susceptibility to motion sickness.
Liu
L
L
Key Laboratory of Molecular Biology, General Hospital of Airforce, Beijing 100036, China. kjliuli@yahoo.com.cn
Yuan
L
L
Wang
H B
HB
Yu
L S
LS
Zheng
J
J
Luo
C Q
CQ
Wang
Y
Y
D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D004247:DNA / Q000032:analysis; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data; D009041:Motion Sickness / Q000235:genetics*; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*
C547768:ADRA2A protein, human; D018341:Receptors, Adrenergic, alpha-2; D004247:DNA