N-acetyltransferase 2 single-nucleotide polymorphisms and risk of gastric carcinoma.
OBJECTIVE
To explore whether an association exists between the NAT2 genotype and the risk of developing gastric cancer.METHODS. Ninety-nine patients with gastric adenocarcinoma and 258 healthy subjects were analysed for single-nucleotide polymorphisms at the NAT2 gene locus, which give rise to gene variants known to be associated with slow-acetylation status.


RESULTS
The functional NAT2*4 (wild-type) allele is over-represented among patients (40.4% of all allelic variants) compared with control subjects [25.8%, odds ratio (OR) 1.95, 95% confidence interval (CI) 1.36, 2.8]. According to the NAT2 genotype, 69 patients (69.9%) and 119 healthy subjects (46%) were classified as rapid acetylators (OR 2.69, 95% CI 1.6, 4.54).


CONCLUSIONS
Our results, which need independent confirmation, suggest that individuals with NAT2 genotypes leading to high levels of NAT2 enzyme activity are at increased risk of developing gastric carcinoma.
Ladero
José M
JM
Gastroenterology Service, Hospital Clínico San Carlos, Medical School, Universidad Complutense, Madrid, Spain. jladero@hcsc.insalud.es
Agúndez
José A G
JA
Olivera
Manuela
M
Lozano
Luis
L
Rodríguez-Lescure
Alvaro
A
Diaz-Rubio
Manuel
M
Benítez
Julio
J
D000107:Acetylation; D000230:Adenocarcinoma / Q000201:enzymology / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001191:Arylamine N-Acetyltransferase / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000201:enzymology / Q000235:genetics*
D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human