2,3,4-Trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran, a novel antioxidant, from Penicillium citrinum F5.
Bioassy-directed fractionation of a culture broth of Penicillium citrinum F5 led to the isolation of a novel antioxidant 2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran (1), together with gentisic acid (2), and their structures were determined on the basis of spectroscopic data. In the 1,1-diphenyl-picryl-hydrazyl (DPPH) assay system, compounds 1 and 2 showed free radical scavenging activity with IC(20) values of 10.39 and 4.26 microM, respectively.
Chen
Chen-Hui
CH
Institute of Biochemistry, National Yang-Ming University, No. 155, Sec 2, Li Nung Street, Peitou, Taipei, Taiwan, 112, Republic of China.
Shaw
Chin-Ying
CY
Chen
Chien-Chih
CC
Tsai
Ying-Chieh
YC
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds; D002851:Chromatography, High Pressure Liquid; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D010851:Picrates; D013624:Taiwan
C460125:2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran; D000975:Antioxidants; D001572:Benzofurans; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl