Watasemycins A and B, new antibiotics produced by Streptomyces sp. TP-A0597.
Two novel antibiotics, watasemycins A and B, were isolated from the fermentation broth of an actinomycete strain. The producing strain TP-A0597 was isolated from the seawater sample collected in Toyama Bay, Japan and identified as Streptomyces sp. based on the taxonomic study. The new antibiotics were obtained by solvent extraction and chromatographic purification and spectroscopic analyses identified that they were new analogs of thiazostatins. Watasemycin possesses a methyl group at 5'-position of thiazostatin instead of a hydrogen atom. Watasemycins showed antibiotic activity against Gram-positive and negative bacteria and yeast.
Sasaki
Omomitsu
O
Biotechnology Research Center, Toyama Prefectural University, Kosugi, Japan.
Igarashi
Yasuhiro
Y
Saito
Noriko
N
Furumai
Tamotsu
T
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D012623:Seawater / Q000382:microbiology; D013302:Streptomyces / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure; D013844:Thiazoles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D053778:Thiazolidines; D015003:Yeasts / Q000187:drug effects
D000900:Anti-Bacterial Agents; D013844:Thiazoles; D053778:Thiazolidines; C456030:watasemycin A; C061469:thiazostatin A