title: Low recurrence of syncope in patients with inducible sustained ventricular tachyarrhythmias treated with an implantable cardioverter-defibrillator.
abstract: OBJECTIVE
  To determine the effectiveness of the implantable cardioverter defibrillator (ICD) in preventing recurrence of syncope in patients with structural heart disease, previously unexplained syncope and inducible ventricular arrhythmias.
  
  
  METHODS
  Thirty-eight patients with syncope, structural heart disease and inducible arrhythmias had an ICD implanted. All ICDs delivered antitachycardia pacing and shocks of adjusted energy. Detection and therapy were programmed according to uniform criteria.
  
  
  RESULTS
  The mean age of the patients was 63+/-11 years and most of them were male (36/38). After a mean follow-up of 28+/-15 (4-61) months, six patients died and one underwent heart transplantation. Syncope recurred in three patients, but in none of them was it caused by an arrhythmic event. In 18 patients, 113 episodes of ventricular tachycardia/ventricular fibrillation were detected and appropriately treated by the ICD. The mean time from implant until first appropriate therapy was 18+/-14 months. The actuarial probability of receiving appropriate therapy was 20% and 42% at 12 and 24 months, respectively.
  
  
  CONCLUSIONS
  In patients with unexplained syncope, structural heart disease and inducible arrhythmias, ICD prevents syncope associated with arrhythmic events. Frequent effective use of antitachycardia pacing and shocks of adjusted energy seem essential to this aim.
authors.affiliation: Arrhythmia Section, Hospital Clínic Universitari, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Garcia-Moran
authors.forename: L
authors.initials: L
authors.lastname: Mont
authors.forename: A
authors.initials: A
authors.lastname: Cuesta
authors.forename: M
authors.initials: M
authors.lastname: Matas
authors.forename: J
authors.initials: J
authors.lastname: Brugada
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D017147:Defibrillators, Implantable; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D016019:Survival Analysis; D013575:Syncope / Q000453:epidemiology / Q000517:prevention & control*; D017180:Tachycardia, Ventricular / Q000628:therapy*; D013997:Time Factors
chemical_list: D000889:Anti-Arrhythmia Agents