title: Changes in high-density lipoprotein-cholesterol subfractions with exercise training may be dependent on cholesteryl ester transfer protein (CETP) genotype.
abstract: We sought to determine if a cholesteryl ester transfer protein (CETP) gene locus variation contributes to the variability in the responses of plasma high-density lipoprotein-cholesterol (HDL-C) and its subfractions to endurance exercise training. Middle- to older-aged men and women with at least 1 lipoprotein-lipid risk factor underwent 6 months of endurance exercise training while on a low-fat diet. Plasma lipid levels were measured by nuclear magnetic resonance (NMR). Initial age, body composition, lipoprotein-lipid profiles, and VO(2)max did not differ between the 2 CETP genotype groups (B1B1, n = 16; B1B2, n = 14). With exercise training, VO(2)max increased, and body weight, total body fat, and computed tomographic (CT) intra-abdominal visceral fat decreased similarly in both CETP genotype groups. Plasma total cholesterol and low-density lipoprotein-cholesterol (LDL-C) levels did not change significantly with training in either genotype group. HDL(2NMR)-C levels increased with exercise training in CETP B1B1 (P <.05), but did not change in CETP B1B2 genotype individuals. HDL(3NMR)-C levels tended to decrease with training in CETP B1B1 persons and HDL(4NMR)-C levels tended to increase with training somewhat more in CETP B1B2 individuals, but these differences were not significant. HDL(5NMR)-C levels increased similarly with exercise training in the 2 groups. The integrated HDL(3-5NMR)-C levels increased with exercise training in CETP B1B2 (P <.05), but did not change in CETP B1B1 genotype individuals. Apolipoprotein E (APO E) or lipoprotein lipase (LPL) PvuII genotype did not associate with HDL-C subfraction changes with training. Thus, CETP genotype may contribute to the interindividual differences in plasma HDL-C subfraction changes occurring with endurance exercise training in sedentary middle- to older-aged men and women.
authors.affiliation: Department of Kinesiology, University of Maryland, College Park, MD 20742-2611, USA.
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Wilund
authors.forename: Robert E
authors.initials: RE
authors.lastname: Ferrell
authors.forename: Dana A
authors.initials: DA
authors.lastname: Phares
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Goldberg
authors.forename: James M
authors.initials: JM
authors.lastname: Hagberg
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics; D001823:Body Composition; D001835:Body Weight / Q000502:physiology; D002352:Carrier Proteins / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000032:analysis / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D018752:Diet, Fat-Restricted; D015444:Exercise / Q000502:physiology*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006023:Glycoproteins; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D014057:Tomography, X-Ray Computed; D044465:White People
chemical_list: D001057:Apolipoproteins E; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006023:Glycoproteins; D002784:Cholesterol; D008071:Lipoprotein Lipase