[Comparison of anti-amnesia properties of NMDA-receptor "fast" blockers and polyamines].
The experiments on rats showed that IEM-1460, IEM-1490, and IEM-1755 (bisammonium adamantyl-containing compounds possessing fast NMDA channel blocking activity) and polyamines (spermine and arcain) do not alter acquiring of the passive avoidance reaction. All these compounds improve, albeit with different efficacy, the memory traces impaired by scopolamine and/or electroshock: IEM-1755 eliminated amnesia induced by the electroshock, but enhanced the amnesia evoked by scopolamine. Arcain inhibited (for a short time and in a narrow dose range) the antiamnesic effect of IEM-1460. It is suggested that the antiamnesic effect of compounds from both groups is related to the ability of slowing down the NMDA receptor desensitization.
Gmiro
V E
VE
Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, Kamennoostrovskii pr. 69/71, St. Petersburg, 197022 Russia.
Zhuravskiĭ
A V
AV
Komissarov
I V
IV
Tikhonov
V N
VN
D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001645:Biguanides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005260:Female; D008297:Male; D008568:Memory / Q000187:drug effects*; D011073:Polyamines / Q000494:pharmacology*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D012601:Scopolamine; D013096:Spermine / Q000494:pharmacology
D001645:Biguanides; D018691:Excitatory Amino Acid Antagonists; C110702:IEM 1460; D011073:Polyamines; D016194:Receptors, N-Methyl-D-Aspartate; D013096:Spermine; C006624:arcaine; D012601:Scopolamine; D000218:Adamantane