[Diuretic activity of the infusion of flowers from Lavandula officinalis].
The diuretic activity of an infusion of Lavandula officinalis was studied in the Wistar rat. Thus, the kinetics of hydroelectrolytic elimination in response to the oral administration of an infusion of pharmaceutical lavender flowers were measured in the rats. Experiments were completed under similar conditions using a synthetic pharmacological diuretic, Diamox. The aqueous extract of this aromatic plant accelerated the elimination of the water overload. At the peak of the diuretic response, urinary osmolarity was significantly less than that of controls (111+/-14 vs. 195+/-11 mosmol x kg(-1)). Sodium excretion was moderate following administration of the infusion when compared to the synthetic diuretic. The stability of the aldosterone concentrations in the plasma and the absence of correlation with plasma sodium concentrations, coupled with the observed clearance of the free water (0.055+/-0.007 vs. 0.045+/-0.012 mL x min(-1)) show that the increase in diuresis and the moderate increase in sodium excretion are of tubular origin. The result of the phytochemical analysis of hexane extracts in the infusion and in urine indicated that four or five chemical factors may be involved in the diuretic effect of lavender.
Elhajili
M
M
Département de Biologie, UFR Endocrinienne et Plantes Médicinales du Bassin Méditerranéen, Faculté des Sciences, Université Mohammed V Rabat, Maroc. baddouri_khadija@hotmail.com
Baddouri
K
K
Elkabbaj
S
S
Meiouat
F
F
Settaf
A
A
D000086:Acetazolamide; D000284:Administration, Oral; D000450:Aldosterone / Q000097:blood; D000818:Animals; D004232:Diuretics / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D027523:Lavandula / Q000737:chemistry*; D009994:Osmolar Concentration; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D016482:Urinalysis / Q000662:veterinary
D004232:Diuretics; D010936:Plant Extracts; D000450:Aldosterone; D000086:Acetazolamide