title: Therapy-related chronic myelogenous leukaemia following autologous stem cell transplantation for Ewing's sarcoma.
abstract: A 17-year-old Japanese woman with Ewing's sarcoma was initially treated with conventional chemotherapy and local irradiation, and then with high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation. Four years later she was diagnosed with chronic myelogenous leukaemia (CML). The BCR/ABL fusion gene was detected in both peripheral blood and bone marrow cells by reverse transcription-polymerase chain reaction, but not in the harvest product of peripheral blood stem cells which were infused at the time of transplantation. This case adds to the accumulating evidence of therapy-related CML developing after high-dose chemotherapy and autologous stem cell transplantation.
authors.affiliation: Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-3-3 Maidashi, Higashi-ku, Fukuoka city, Fukuoka 812-8582, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Numata
authors.forename: Kazuya
authors.initials: K
authors.lastname: Shimoda
authors.forename: Hisashi
authors.initials: H
authors.lastname: Gondo
authors.forename: Kouji
authors.initials: K
authors.lastname: Kato
authors.forename: Kenichi
authors.initials: K
authors.lastname: Aoki
authors.forename: Yoshikiyo
authors.initials: Y
authors.lastname: Ito
authors.forename: Ken
authors.initials: K
authors.lastname: Takase
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Asano
authors.forename: Takashi
authors.initials: T
authors.lastname: Okamura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Niho
authors.forename: Mine
authors.initials: M
authors.lastname: Harada
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000209:etiology*; D012512:Sarcoma, Ewing / Q000628:therapy*