title: Associating community prevalence of Schistosoma mansoni infection with prevalence of signs and symptoms.
abstract: Information on the prevalence of morbidity is needed for re-calculation of the Global Burden of Disease (WHO) due to Schistosoma mansoni. This study presents a statistical association which can be used to predict the prevalence of morbidity from the prevalence of S. mansoni in a community. We collected data from field studies reporting prevalence of infection and prevalence of morbidity. Data on infection prevalence were standardised to a default diagnostic sensitivity (i.e. Kato-Katz technique 41.7 mg). The data were described by an expression related to logistic regression. We determined associations between prevalence of infection and prevalence of early morbidity (diarrhoea, blood in stool and abdominal pain), hepatosplenic morbidity and late morbidity (haematemesis and ascitis). Diarrhoea and blood in stool due to S. mansoni infection mainly occurs in communities with a high prevalence of infection. An influence on hepatosplenic morbidity is already present at low community prevalence of infection. For the aspecific symptom abdominal pain we did not find an association.
authors.affiliation: Department of Public Health, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands. vanderwerf@mgz.fgg.eur.nl
authors.forename: Marieke J
authors.initials: MJ
authors.lastname: van der Werf
authors.forename: Sake J
authors.initials: SJ
authors.lastname: de Vlas
authors.forename: Caspar W N
authors.initials: CW
authors.lastname: Looman
authors.forename: Nico J D
authors.initials: NJ
authors.lastname: Nagelkerke
authors.forename: J Dik F
authors.initials: JD
authors.lastname: Habbema
authors.forename: Dirk
authors.initials: D
authors.lastname: Engels
mesh_terms: D000328:Adult; D002648:Child; D016208:Databases, Factual; D006801:Humans; D016015:Logistic Models; D015995:Prevalence; D012555:Schistosomiasis mansoni / Q000453:epidemiology* / Q000503:physiopathology