title: Novel cycloaddition of nitriles with monolithio- and dilithiobutadienes.
abstract: Two novel and synthetically useful reaction patterns of organolithium compounds with nitriles are reported to afford pyridine derivatives as the final products. Both 1-lithio-1,3-dienes and 1,4-dilithio-1,3-dienes, which can be easily generated in situ by lithiation of their corresponding iodo compounds, react with nitriles in the presence of HMPA to form substituted pyridines including 2,2'-bipyridines and tetrahydroisoquinolines in high yields.
authors.affiliation: Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 China.
authors.forename: Jinglong
authors.initials: J
authors.lastname: Chen
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Song
authors.forename: Congyang
authors.initials: C
authors.lastname: Wang
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Xi