title: Intrathecal midazolam for postoperative pain relief in caesarean section delivery.
abstract: Postoperative pain relief is a growing concern to an anaesthesiologist since no single analgesic is free from side-effects. Moreover, it becomes a challenge after caesarean section delivery to provide postoperative pain relief without much sedation, respiratory depression or problems like nausea, vomiting, so that early baby acceptance and care by mother is promoted. Antinociceptive effect of midazolam is well established by now and its safety is documented. This observation was made in a blind randomised study of 40 women of ASA I/II to evaluate postoperative pain relief using intrathecal midazolam in caesarean section delivery. Group A patients (n=20) received 1.5 ml of 5% lignocaine only and group B patients (n=20) received mixture of 1.5 ml 5% lignocaine with 2 mg midazolam (preservative free) through intrathecal route at L3.4 interspace; vital parameters were monitored intra-operatively and postoperatively and Apgar score of baby in 1st and 5th minute of deliverywas assessed. It was observed intrathecal midazolam produced highly significant (p<0.001) postoperative pain relief together with anti-emetic effect and tranquillity of patients of caesarean section delivery.
authors.affiliation: Department of Anaesthesiology, Calcutta National Medical College and Hospital, India.
authors.forename: A
authors.initials: A
authors.lastname: Sen
authors.forename: A
authors.initials: A
authors.lastname: Rudra
authors.forename: S K
authors.initials: SK
authors.lastname: Sarkar
authors.forename: B
authors.initials: B
authors.lastname: Biswas
mesh_terms: D000759:Adjuvants, Anesthesia / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000775:Anesthesia, Spinal; D002585:Cesarean Section; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008874:Midazolam / Q000009:adverse effects / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*; D020250:Postoperative Nausea and Vomiting / Q000139:chemically induced; D011247:Pregnancy; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D000759:Adjuvants, Anesthesia; D008012:Lidocaine; D008874:Midazolam