title: Lewy body-free nigral degeneration--a case report.
abstract: A 70-year-old Japanese woman developed progressive, dopa-responsive parkinsonism consisting of akinesia, resting tremor, rigidity, and postural instability. Neuropathological examination revealed a marked loss of nigral neurons, but no Lewy bodies (LBs) were observed. Lewy bodies were also absent from their usual site, with the exception of a small number seen in the dorsal motor nucleus of the vagus nerve (DVN) and sympathetic ganglion. We propose that our case and several similar reported cases represent Lewy body-free nigral degeneration.
authors.affiliation: Department of Neurology, Showa University School of Medicine, Shinagawa, Tokyo, Japan. kishi@med.showa-u.ac.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishihara
authors.forename: Akiko
authors.initials: A
authors.lastname: Nonaka
authors.forename: Toshiya
authors.initials: T
authors.lastname: Fukui
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kawamura
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Shiota
authors.forename: Imaharu
authors.initials: I
authors.lastname: Nakano
mesh_terms: D000368:Aged; D004295:Dihydroxyphenylalanine / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology*; D009410:Nerve Degeneration / Q000473:pathology*; D020734:Parkinsonian Disorders / Q000188:drug therapy / Q000473:pathology*; D013378:Substantia Nigra / Q000473:pathology*
chemical_list: D004295:Dihydroxyphenylalanine