title: [Effect of L-arginine and the nitric oxide synthase blocker L-NNA on calcium capacity in rat liver mitochondria with differing resistance to hypoxia].
abstract: The effect of L-arginine and blockator of nitric oxide synthase L-NNA on processes of calcium mitochondrial capacity in liver with different resistance to hypoxia in the experiments with Wistar rats has been studied using the followrng substrates of energy support: succinic, alpha-ketoglutaric acids, alpha-ketolutarate and inhibitor succinatedehydrogenase malonate. As well we used substrates mixtures combination providing for activation of aminotransferase mechanism: glutamate and piruvate, glutamate and malate. It has been shown that L-arginine injection increases calcium mitochondrial capacity of low resistant rats using as substrates the succinate and alpha-ketoglutarate to control meanings of high resistance rats. Effects of donors nitric oxide on this processes limit NO-synthase inhibitor L-NNA.
authors.affiliation: Franko Lviv National University, Ukraine.
authors.forename: N M
authors.initials: NM
authors.lastname: Kurhaliuk
authors.forename: O V
authors.initials: OV
authors.lastname: Ikkert
authors.forename: L S
authors.initials: LS
authors.lastname: Vovkanych
authors.forename: O V
authors.initials: OV
authors.lastname: Horyn'
authors.forename: M O
authors.initials: MO
authors.lastname: Hal'kiv
authors.forename: S K
authors.initials: SK
authors.lastname: Hordiĭ
mesh_terms: D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D000860:Hypoxia / Q000378:metabolism*; D007656:Ketoglutaric Acids / Q000494:pharmacology; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D019335:Nitroarginine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013379:Substrate Specificity; D019802:Succinic Acid / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D007656:Ketoglutaric Acids; D019335:Nitroarginine; D001120:Arginine; D019802:Succinic Acid; D019001:Nitric Oxide Synthase; D002118:Calcium