title: Synovial metaplasia, a specialized form of repair.
abstract: Synovial metaplasia is a change seen most frequently in the tissues surrounding silicone breast prostheses and in healing tissue adjacent to joint prostheses. It has also been described in skin and soft tissues, most frequently in healing or healed traumatic or surgical wounds. We report a case of synovial metaplasia occurring in a hitherto unreported location, namely, adjacent to a silicone low-pressure voice prosthesis. A review of cases of synovial metaplasia reported in the literature revealed that in most cases, spaces that form adjacent to foreign material (most commonly silicone breast prostheses) and the smooth gliding surfaces of the foreign material that resist penetration by fibroblast processes are frequent associated findings that precede the occurrence of synovial metaplasia. Thus, synovial metaplasia might represent a specialized form of healing in cases that have this combination of physical features.
authors.affiliation: Department of Pathology, Louisiana State University Health Sciences Center, Shreveport 71130-3932, USA. Mfowle@lsuhsc.edu
authors.forename: Marjorie R
authors.initials: MR
authors.lastname: Fowler
authors.forename: Cherie-Ann O
authors.initials: CO
authors.lastname: Nathan
authors.forename: Fleurette
authors.initials: F
authors.lastname: Abreo
mesh_terms: D005260:Female; D005549:Foreign-Body Reaction / Q000139:chemically induced / Q000473:pathology*; D006801:Humans; D007831:Larynx, Artificial; D008679:Metaplasia / Q000473:pathology; D008875:Middle Aged; D012828:Silicones / Q000009:adverse effects; D013583:Synovial Membrane / Q000187:drug effects / Q000473:pathology*; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
chemical_list: D012828:Silicones