title: Comparative genomic hybridization analysis of benign and invasive male breast neoplasms.
abstract: Comparative genomic hybridization (CGH) analysis was performed for the identification of chromosomal imbalances in two benign gynecomastias and one malignant breast carcinoma derived from patients with male breast disease and compared with cytogenetic analysis in two of the three cases. CGH analysis demonstrated overrepresentation of 8q in all three cases. One case of gynecomastia presented gain of 1p34.3 through pter, 11p14 through q12, and 17p11.2 through qter, and loss of 1q41 through qter and 4q33 through qter. The other gynecomastia presented del(1)(q41) as detected by both cytogenetic and CGH analysis. CGH analysis of the invasive ductal carcinoma confirmed a gain of 17p11.2 through qter previously detected by cytogenetic analysis. These regions showed some similarity in their pattern of imbalance to the chromosomal alterations described in female and male breast cancer.
authors.affiliation: Department of Genetics, IB-UNESP, Botucatu, São Paulo, Brazil.
authors.forename: Elida Paula Benquique
authors.initials: EP
authors.lastname: Ojopi
authors.forename: Luciane Regina
authors.initials: LR
authors.lastname: Cavalli
authors.forename: Luciane Mara Bogline
authors.initials: LM
authors.lastname: Cavalieri
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: Squire
authors.forename: Silvia Regina
authors.initials: SR
authors.lastname: Rogatto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018567:Breast Neoplasms, Male / Q000235:genetics* / Q000473:pathology*; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D020732:Cytogenetic Analysis; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness / Q000235:genetics*; D009693:Nucleic Acid Hybridization