Successful pregnancy in a 42-year-old woman with imminent ovarian failure following ovulation induction with ethinyl estradiol without gonadotropins and in vitro fertilization.
OBJECTIVE
To describe the methodology used to induce ovulation in a 41-year-old woman with imminent ovarian failure and tubal factor so that in vitro fertilization-embryo transfer (IVF-ET) could be performed.


METHODS
Ethinyl estradiol was used to suppress elevated serum follicle stimulating hormone (FSH) levels, thus theoretically allowing restoration of down-regulated FSH receptors and response to endogenous gonadotropins.


RESULTS
One oocyte was retrieved and fertilized and one embryo was transferred. The patient conceived and is presently in her last trimester.


CONCLUSIONS
Successful pregnancy following IVF-ET is possible in women with imminent ovarian failure - even in women older than age 40.
Check
M L
ML
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, USA.
Check
J H
JH
Choe
J K
JK
Berger
G S
GS
D000328:Adult; D004624:Embryo Transfer; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000628:therapy*; D007986:Luteinizing Hormone / Q000097:blood; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome
D004997:Ethinyl Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone