Impact of prior nicotine replacement therapy on smoking cessation efficacy.
OBJECTIVE
To examine previous use of nicotine replacement therapy (NRT) on the smoking-cessation efficacy of bupropion sustained release (SR).


METHODS
Secondary analysis of a parallel-group, randomized, double-blind, placebo-controlled study. Smokers who had, based on self-report, no previous history of NRT (N = 453) or who had used NRT at least once (N = 440) were randomized to receive placebo, bupropion SR, nicotine transdermal system (NTS), or a combination of bupropion SR and NTS.


RESULTS
Bupropion SR showed similar efficacy in participants with or without previous use of NRT.


CONCLUSIONS
Bupropion SR is effective in promoting smoking abstinence regardless of prior NRT use.
Durcan
Michael J
MJ
GlaxoSmithKline, Research Triangle Park, NC 27709, USA. mjd15743@GlaxoWellcome.com
White
Jonathan
J
Jorenby
Douglas E
DE
Fiore
Michael C
MC
Rennard
Stephen I
SI
Leischow
Scott J
SJ
Nides
Mitchell A
MA
Ascher
John A
JA
Johnston
J Andrew
JA
D000279:Administration, Cutaneous; D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage / Q000627:therapeutic use*; D016540:Smoking Cessation / Q000379:methods*; D014029:Tobacco Use Disorder / Q000188:drug therapy*; D016896:Treatment Outcome; D014481:United States
D018687:Antidepressive Agents, Second-Generation; D009538:Nicotine