Conservative treatment of malignant (invasive) external otitis caused by Aspergillus flavus with oral itraconazole solution in a neutropenic patient.
Aspergillus flavus causes invasive external otitis associated with severe infection of the skull base. A combination of amphotericin B, surgical debridement and long-term itraconazole is considered the therapy of choice. We report a case of invasive external otitis due to A. flavus that was treated successfully with a short course of amphotericin B and long-term oral itraconazole without surgical intervention.
Finer
Gal
G
Pediatric Department, Soroka University Medical Center, and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Greenberg
David
D
Leibovitz
Eugene
E
Leiberman
Alberto
A
Shelef
Ilan
I
Kapelushnik
Joseph
J
D000284:Administration, Oral; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001231:Aspergillus flavus / Q000302:isolation & purification*; D002648:Child; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009181:Mycoses / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology*; D009503:Neutropenia / Q000150:complications* / Q000382:microbiology; D010032:Otitis Externa / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology*
D000935:Antifungal Agents; D017964:Itraconazole