Shear stress levels in paralyzed legs of spinal cord-injured individuals with and without nerve degeneration.
The purpose of this study was to assess the relationship between inactivity and shear stress, the frictional force of blood against the endothelium, in spinal cord injury (SCI) subjects. SCI group offers a unique "model of nature" to study the effects of inactivity. Nine SCI subjects with upper (SCI-U) and 5 with a lower (SCI-L) motoneuron lesion and 10 able-bodied controls (C) were included. A venous blood sample was withdrawn to determine blood viscosity. Red blood cell velocities and arterial diameters of the common carotid artery (CCA) and common femoral artery (CFA) were measured by using echo-Doppler ultrasound in a supine position. No differences were observed in wall shear stress in the CCA between groups. In the CFA, peak and mean wall shear stress were significantly increased in SCI (14.1 and 1.2 Pa, respectively) compared with C (10.2 and 0.9 Pa, respectively). Because SCI-U and SCI-L showed no differences in shear stress levels, inactivity and not nerve degeneration seems to cause the elevated shear stress levels in the CFA in SCI. However, the lack of central neural control as a causal factor cannot be ruled out.
Boot
Cécile R L
CR
Department of Physiology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands.
Groothuis
Jan T
JT
Van Langen
Herman
H
Hopman
Maria T E
MT
D000328:Adult; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000503:physiopathology; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D007866:Leg; D009410:Nerve Degeneration / Q000150:complications*; D010243:Paralysis / Q000209:etiology* / Q000503:physiopathology*; D012016:Reference Values; D013119:Spinal Cord Injuries / Q000150:complications*; D013314:Stress, Mechanical; D013904:Thoracic Vertebrae; D018615:Ultrasonography, Doppler, Color