[Synthesis of several analogues of antifungal steroid alkaloids].
In order to search for new type antifungal drugs, seven analogues of antifungal alkaloids were synthesized, each through a reaction sequence of ten or eleven steps, using the commercially available steroid, 3 beta-acetoxy-5, 16-pregnadiene-20-one as the starting material. The preliminary antifungal tests in vitro showed that compounds 3a-c, and 5 were more effective than fluoconazole. Nineteen new compounds were synthesized in this work.
Chen
Y
Y
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031.
Zhou
Q
Q
Bai
D
D
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D015725:Fluconazole / Q000494:pharmacology; D015394:Molecular Structure; D013256:Steroids
D000470:Alkaloids; D000935:Antifungal Agents; D013256:Steroids; D015725:Fluconazole