title: Simultaneous mining of linkage and linkage disequilibrium to fine map quantitative trait loci in outbred half-sib pedigrees: revisiting the location of a quantitative trait locus with major effect on milk production on bovine chromosome 14.
abstract: A maximum-likelihood QTL mapping method that simultaneously exploits linkage and linkage disequilibrium and that is applicable in outbred half-sib pedigrees is described. The method is applied to fine map a QTL with major effect on milk fat content in a 3-cM marker interval on proximal BTA14. This proximal location is confirmed by applying a haplotype-based association method referred to as recombinant ancestral haplotype analysis. The origin of the discrepancy between the QTL position derived in this work and that of a previous analysis is examined and shown to be due to the existence of distinct marker haplotypes associated with QTL alleles having large substitution effects.
authors.affiliation: Department of Genetics, Faculty of Veterinary Medicine, University of Liège (B43), 4000-Liège, Belgium.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Farnir
authors.forename: Bernard
authors.initials: B
authors.lastname: Grisart
authors.forename: Wouter
authors.initials: W
authors.lastname: Coppieters
authors.forename: Juliette
authors.initials: J
authors.lastname: Riquet
authors.forename: Paulette
authors.initials: P
authors.lastname: Berzi
authors.forename: Nadine
authors.initials: N
authors.lastname: Cambisano
authors.forename: Latifa
authors.initials: L
authors.lastname: Karim
authors.forename: Myriam
authors.initials: M
authors.lastname: Mni
authors.forename: Sirja
authors.initials: S
authors.lastname: Moisio
authors.forename: Patricia
authors.initials: P
authors.lastname: Simon
authors.forename: Danny
authors.initials: D
authors.lastname: Wagenaar
authors.forename: Johanna
authors.initials: J
authors.lastname: Vilkki
authors.forename: Michel
authors.initials: M
authors.lastname: Georges
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods* / Q000706:statistics & numerical data / Q000662:veterinary; D006239:Haplotypes; D007774:Lactation; D016013:Likelihood Functions; D015810:Linkage Disequilibrium; D008126:Lod Score; D008892:Milk / Q000378:metabolism; D010375:Pedigree; D019655:Quantitative Trait, Heritable