International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: analyzing target autoantigens of humoral immunity in nonobese diabetic mice.
The aim of this workshop was to identify autoantibody assays that could provide useful markers of autoimmunity in the NOD mouse model for type 1 diabetes. It was demonstrated that insulin autoantibodies measured by sensitive radiobinding assay are a marker of autoimmunity in NOD mice and draw into question the true nature of GADA and IA-2A in this animal model.
Bonifacio
Ezio
E
Department of Medicine, Istituto Scientifico San Raffaele, Milan, Italy. bonifacio.ezio@hsr.it
Atkinson
Mark
M
Eisenbarth
George
G
Serreze
David
D
Kay
Thomas W H
TW
Lee-Chan
Edwin
E
Singh
Bhagirath
B
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007328:Insulin / Q000276:immunology; D051379:Mice; D016688:Mice, Inbred NOD
D001323:Autoantibodies; D001324:Autoantigens; D007328:Insulin; D005968:Glutamate Decarboxylase