title: Propofol reduces spinal motor neuron excitability in humans.
abstract: We investigated in humans whether changes in spinal motor neuron excitability correlate with the predicted propofol concentration (Cpt) achieved by a target-controlled infusion system. Propofol suppressed F-wave persistence in a Cpt-dependent manner, indicating that propofol depresses spinal motor neuron excitability at clinically relevant concentrations.
authors.affiliation: Division of Anesthesia, Okinawa Prefectural Miyako Hospital, Okinawa, Japan. mnb-shk@ryukyu.ne.jp
authors.forename: Manabu
authors.initials: M
authors.lastname: Kakinohana
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Fuchigami
authors.forename: Seiya
authors.initials: S
authors.lastname: Nakamura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kawabata
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sugahara
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000166:cytology / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects*; D019635:Neurosurgical Procedures; D015742:Propofol / Q000008:administration & dosage; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol