title: Acquired factor VIII inhibitors as a cause of primary post-partum haemorrhage.
abstract: Acquired haemophilia was diagnosed following detailed investigation of a post-partum haemorrhage unresponsive to standard management. Circulating factor VIII inhibitors and low factor VIII levels were detected and intravenous DDAVP treatment lead to a resolution of symptoms. This case highlights the importance of haematological investigations in persisting post-partum haemorrhage.
authors.affiliation: Departments of Obstetrics and Gynaecology and Haematology, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UK.
authors.forename: E J
authors.initials: EJ
authors.lastname: Howland
authors.forename: Julia
authors.initials: J
authors.lastname: Palmer
authors.forename: Matthew
authors.initials: M
authors.lastname: Lumley
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Keay
mesh_terms: D000328:Adult; D001323:Autoantibodies; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000627:therapeutic use; D005169:Factor VIII / Q000032:analysis / Q000276:immunology*; D005260:Female; D006467:Hemophilia A / Q000276:immunology; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D010314:Partial Thromboplastin Time; D006473:Postpartum Hemorrhage / Q000188:drug therapy / Q000276:immunology*; D014148:Tranexamic Acid / Q000627:therapeutic use
chemical_list: D001323:Autoantibodies; D006490:Hemostatics; D014148:Tranexamic Acid; D005169:Factor VIII; D003894:Deamino Arginine Vasopressin