Priapism associated with zuclopenthixol.
OBJECTIVE
To present a single case of zuclopenthixol-induced priapism and a literature review.


METHODS
We report the case of a 31-year-old patient hospitalized due to behavioral alterations and treated with oral zuclopenthixol, an antipsychotic from the thioxanthene family, who developed an acute, painful erection.


CONCLUSIONS
The occurrence of priapism in our patient was related to zuclopenthixol. This adverse reaction is reported for the first time in a patient not concomitantly treated with other drugs associated with the appearance of priapism. The capacity of zuclopenthixol to induce priapism is thought to be due to its antagonist activity on alpha-adrenergic receptors.


CONCLUSIONS
Priapism is an uncommon but potentially serious adverse effect of zuclopenthixol that practitioners, as with many other antipsychotics, should be aware of.
Salado
Julio
J
Medical Staff, Complejo Asistencial Benito Menni, Ciempozuelos, Spain.
Blázquez
Antonio
A
Díaz-Simón
Raquel
R
López-Muñoz
Franciso
F
Alamo
Cecilio
C
Rubio
Gabriel
G
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003006:Clopenthixol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000627:therapeutic use; D011317:Priapism / Q000139:chemically induced* / Q000188:drug therapy
D014150:Antipsychotic Agents; D003006:Clopenthixol; D009638:Norepinephrine