ATP-sensitive K(+) channels in the brain: sensors of hypoxic conditions.
Rapid minimization of energy consumption in excitable tissues is effective protection from lethal effects of extreme metabolic stress. The ATP-sensitive K(+) channels in the brain respond in ATP-depleted metabolic states such as hypoxia and may be involved in the protection mechanism against energy-consuming generalized seizure.
Yamada
Katsuya
K
Department of Physiology, Akita University School of Medicine, Japan.
Inagaki
Nobuya
N
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D002534:Hypoxia, Brain / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism*
D015221:Potassium Channels; D000255:Adenosine Triphosphate