title: [Gene diagnosis of hemophilia B by multiple STR analysis].
abstract: OBJECTIVE
  To establish a simple, rapid genetic diagnostic system for haemophilia B.
  
  
  METHODS
  The polymorphisms of eight STR loci in 87 normal persons and 8 haemophilia B families were assayed by PCR and genescan, and the linkage relations were analysed.
  
  
  RESULTS
  Six of the eight STR loci can provide genetic information for haemophilia B, and the heterozygosity is 0.50 approximately 0.83, PIC 0.39 approximately 0.80, and DP 0.66 approximately 0.94.
  
  
  CONCLUSIONS
  Combination of multiple STR loci analysis could be effective method for genetic diagnosis of haemophilia B.
authors.affiliation: Shanghai Ruijin Hospital, Shanghai Institute of Hematology, Shanghai 200025, China.
authors.forename: Xiangfan
authors.initials: X
authors.lastname: Liu
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Wang
authors.forename: Qishi
authors.initials: Q
authors.lastname: Fan
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chu
authors.forename: Yi
authors.initials: Y
authors.lastname: Fang
authors.forename: Hongli
authors.initials: H
authors.lastname: Wang
mesh_terms: D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D002836:Hemophilia B / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic