TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis.
In order to determine whether TNF-alpha, IL1-beta, GM, and KM genes affect susceptibility to sarcoidosis, coded DNA samples from 278 Caucasian and 219 African-American patients and an equal number of matched controls were genotyped by polymerase chain reaction methods. All genotypes were in Hardy-Weinberg equilibrium. Genotype frequencies in sarcoidosis patients, as a whole, were not significantly different from that in controls. Additional analyses were performed to determine whether patients with and without erythema nodosum had different genetic components. In African-American patients without erythema nodosum, the distribution of KM genotypes was significantly different from that in controls: compared to controls, the frequency of KM1 homozygotes was increased in patients (6.5% versus 13.0%, p = 0.01; odds ratio = 2.56). As KM genes have been reported to be associated with immune responsiveness to several pathogens, these results may be relevant to the etiology of sarcoidosis.
Pandey
Janardan P
JP
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston 29425-2230, USA. pandeyj@musc.edu
Frederick
Margaret
M
D044383:Black People / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics; D007375:Interleukin-1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012507:Sarcoidosis / Q000150:complications / Q000235:genetics*; D012680:Sensitivity and Specificity; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000235:genetics; D001741:Black or African American
D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha