Synthesis of aliphatic ketones from allylic alcohols through consecutive isomerization and chelation-assisted hydroacylation by a rhodium catalyst.
An allylic alcohol, utilized as a precursor for an aliphatic aldehyde, reacted with olefins to afford aliphatic ketones in the presence of RhCl(PPh(3))(3), 2-amino-4-picoline, aniline, and benzoic acid through a tandem reaction of an isomerization and a chelation-assisted hydroacylation.
Lee
Dae-Yon
DY
Department of Chemistry, Yonsei University, Seoul 120-749, South Korea.
Moon
Choong Woon
CW
Jun
Chul-Ho
CH