title: SET-domain proteins of the Su(var)3-9, E(z) and trithorax families.
abstract: SET-domain (SET: Su(var)3-9, E(z) and Trithorax)-containing proteins were collected through sequence searches of the available databases. After removing redundancies, the proteins belonging to three families, SU(VAR)3-9, E(Z) and Trithorax, were selected. Analysis of the relationship between the different members is based on pairwise alignment, compilation, and comparison of their SET-domains. The level of homology of the SET-domains defined the distribution of the proteins into families and into clades within the families. The architecture of the entire protein supported the distribution pattern built upon SET-domain similarity. Parallel cladistic and protein-architecture analyses outlined two plausible criteria for predicting function.
authors.affiliation: Department of Biological Sciences, Lilly Hall of Life Sciences, Purdue University, West Lafayette, IN 47907-1392, USA.
authors.forename: Raul
authors.initials: R
authors.lastname: Alvarez-Venegas
authors.forename: Zoya
authors.initials: Z
authors.lastname: Avramova
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D029721:Drosophila Proteins; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics*; D010802:Phylogeny; D010944:Plants / Q000235:genetics; D063151:Polycomb Repressive Complex 2; D012097:Repressor Proteins / Q000235:genetics*; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; C089148:Su(var)3-9 protein, Drosophila; D014157:Transcription Factors; C063460:Trl protein, Drosophila; C083329:E(z) protein, Drosophila; D063151:Polycomb Repressive Complex 2