title: Visual cortex reactivity in sedated children examined with perfusion MRI (FAIR).
abstract: Sleeping and sedated children can respond to visual stimulation with a decrease in blood oxygenation level dependent (BOLD) functional MRI signal response. The contribution of metabolic and hemodynamic parameters to this inverse signal response is incompletely understood. It has been hypothesized that it is caused by a relatively greater increase of oxygen consumption compared to rCBF (regional cerebral blood flow) increase. We studied the rCBF changes during visual stimulation in four sedated children, aged 4-71 months, and four alert adults, with an arterial water spin labeling technique (FAIR) and BOLD fMRI in a 1.5T MR scanner. In the children, FAIR signal decreased by a mean of 0.96% (range 0.77-1.05) of the baseline periods of the non-selective images, while BOLD signal decreased by 2.03% (range 1.99-2.93). In the adults, FAIR and BOLD signal increased by 0.88% (range 0.8-0.99) and 2.63% (range 1.99-2.93), respectively. Thus, in the children, an rCBF increase could not be detected by perfusion MRI, but indications of a FAIR signal decrease were found. An rCBF decrease in the primary visual cortex during stimulation has not been reported previously, but it is a possible explanation for the negative BOLD response. Future studies will have to address if this response pattern is a consequence of age or sleep/sedation.
authors.affiliation: Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Glostrup, Denmark. pborn@magnet.drcmr.dk
authors.forename: A P
authors.initials: AP
authors.lastname: Born
authors.forename: E
authors.initials: E
authors.lastname: Rostrup
authors.forename: M J
authors.initials: MJ
authors.lastname: Miranda
authors.forename: H B W
authors.initials: HB
authors.lastname: Larsson
authors.forename: H C
authors.initials: HC
authors.lastname: Lou
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006993:Hypnotics and Sedatives; D007223:Infant; D008279:Magnetic Resonance Imaging; D010101:Oxygen Consumption; D010775:Photic Stimulation; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology*
chemical_list: D006993:Hypnotics and Sedatives