Neuroprotective agents in acute ischemic stroke.
The concept of neuroprotection relies on the principle that delayed neuronal injury occurs after ischemia. The phenomenon of the "ischemic cascade" has been described, and each step along this cascade provides a target for therapeutic intervention. A wide variety of drugs have been studied in humans. Ten classes of neuroprotective agents have reached phase III efficacy trials but have shown mixed results. They included calcium channel antagonists, NMDA receptor antagonists, lubeluzole, CDP-choline, the free radical scavenger tirilazad and ebselen, enlimomab, GABA agonist clomethiazole, the sodium channel antagonist fosphenytoin, magnesium, glycine site antagonist GV150526 and piracetam. Furthermore, the mechanisms that underlie the development of focal ischemic injury continue to be discovered, opening new therapeutic perspective for neuroprotection that might clinically be applicable in the future.
Sareen
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Department of Neurology, St. Stephen's Hospital, Tis Hazari, New Delhi.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002719:Chlormethiazole / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D017326:Clinical Trials, Phase III as Topic; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D018846:Excitatory Amino Acids / Q000037:antagonists & inhibitors / Q000502:physiology; D005544:Forecasting; D018757:GABA Modulators / Q000627:therapeutic use; D006146:Guanidines / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D008875:Middle Aged; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010875:Pipecolic Acids / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D011810:Quinoxalines / Q000627:therapeutic use; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology; D015427:Reperfusion Injury / Q000517:prevention & control; D020521:Stroke / Q000188:drug therapy*; D013844:Thiazoles / Q000627:therapeutic use
D000975:Antioxidants; D002121:Calcium Channel Blockers; D018691:Excitatory Amino Acid Antagonists; D018846:Excitatory Amino Acids; D018757:GABA Modulators; D006146:Guanidines; D007093:Imidazoles; D009292:Narcotic Antagonists; D018696:Neuroprotective Agents; D010875:Pipecolic Acids; D010880:Piperidines; D011810:Quinoxalines; D016194:Receptors, N-Methyl-D-Aspartate; D013844:Thiazoles; D002719:Chlormethiazole; C110629:YM 872; C079779:aptiganel; C053672:selfotel; D009271:Naltrexone; C038981:nalmefene; C097722:lubeluzole