title: Diagnosing non-palpable breast disease: short-term impact on quality of life of large-core needle biopsy versus open breast biopsy.
abstract: BACKGROUND
  One of the alleged advantages of stereotactic large-core needle biopsy of non-palpable breast lesions is that it entails less inconvenience for the patient. In this prospective study, the quality of life of patients undergoing large-core needle biopsy was compared with that of patients undergoing open breast biopsy prior to learning the definitive diagnosis.
  
  
  METHODS
  Thirty patients with non-palpable breast lesions underwent stereotactic large-core needle biopsy as initial diagnostic procedure (needle biopsy group). Quality of life as perceived by these patients was compared with that of 27 patients who underwent open breast biopsy as initial diagnostic procedure (control group). Both groups completed quality of life questionnaires (EuroQol and SF-36) 1 day before and 4 days after the diagnostic intervention.
  
  
  RESULTS
  One day before the diagnostic procedure, the overall estimate for quality of life (measured with the EuroQol) was slightly higher in the needle biopsy group than in the control group (73 versus 69 resp.). Four days after the diagnostic procedure, the quality of life score remained approximately unchanged in the needle biopsy group, but was reduced in the control group (71 versus 61 resp.). Results of the SF-36 questionnaire demonstrated that patients in the needle biopsy group had higher quality of life scores on physical functioning, physical performance, pain and social performance after the diagnostic intervention.
  
  
  CONCLUSIONS
  Stereotactic large-core needle biopsy seems to affect quality of life to a lesser extent than open breast biopsy. This difference is mainly attributable to a reduction of physical discomfort and pain.
authors.affiliation: Department of Surgery, University Medical Center, Utrecht, The Netherlands. lenny.verkooijen@imsp.unige.ch
authors.forename: H M
authors.initials: HM
authors.lastname: Verkooijen
authors.forename: E
authors.initials: E
authors.lastname: Buskens
authors.forename: P H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: I H M
authors.initials: IH
authors.lastname: Borel Rinkes
authors.forename: H J
authors.initials: HJ
authors.lastname: de Koning
authors.forename: Th J M V
authors.initials: TJ
authors.lastname: van Vroonhoven
mesh_terms: D001707:Biopsy, Needle / Q000379:methods*; D001940:Breast / Q000473:pathology*; D001941:Breast Diseases / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires