title: Medical management of early fetal demise using sublingual misoprostol.
abstract: The aim of this study was to determine the efficacy of mifepristone in combination with sublingual misoprostol for the medical management of early fetal demise. Fifty-six consecutive women were studied prospectively. The mean (SD) gestation at diagnosis was 9.6 weeks (1.84). Four women had complete miscarriage with mifepristone alone. The overall success rate was 83.9% and the median induction-miscarriage interval was 8.19 hours (range 0.83 to 37.50 hours). Of those women who had a successful outcome, 91.5% were satisfied with the regimen. Sublingual misoprostol in combination with mifepristone is an effective and safe alternative to vaginal or oral misoprostol in the management of early fetal demise.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Aberdeen, UK.
authors.forename: Prabhath T
authors.initials: PT
authors.lastname: Wagaarachchi
authors.forename: Premila W
authors.initials: PW
authors.lastname: Ashok
authors.forename: Norman C
authors.initials: NC
authors.lastname: Smith
authors.forename: Allan
authors.initials: A
authors.lastname: Templeton
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage*; D000028:Abortion, Induced / Q000379:methods*; D000282:Administration, Intravaginal; D000286:Administration, Sublingual; D000293:Adolescent; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D005313:Fetal Death; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage*; D016595:Misoprostol / Q000008:administration & dosage*; D010865:Pilot Projects; D011247:Pregnancy; D011446:Prospective Studies; D012606:Scotland
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D016595:Misoprostol; D015735:Mifepristone