title: Spatial and temporal disease progression of adult-onset subacute sclerosing panencephalitis.
abstract: An adult-onset case of subacute sclerosing panencephalitis with occipitofrontal spread of the infection documented clinically and by MRI is reported. Autopsy revealed numerous intranuclear viral inclusions and widespread demyelination in both frontal lobes. In the occipital lobes where the disease started 5 years previously, inclusions were rare, but degenerative tissue changes were prominent. This case underlines the importance of measles virus migration for the progression of this fatal disorder.
authors.affiliation: Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany. christian.mawrin@medizin.uni-magdeburg.de
authors.forename: C
authors.initials: C
authors.lastname: Mawrin
authors.forename: H
authors.initials: H
authors.lastname: Lins
authors.forename: B
authors.initials: B
authors.lastname: Koenig
authors.forename: T
authors.initials: T
authors.lastname: Heinrichs
authors.forename: S
authors.initials: S
authors.lastname: Murayama
authors.forename: E
authors.initials: E
authors.lastname: Kirches
authors.forename: C
authors.initials: C
authors.lastname: Boltze
authors.forename: K
authors.initials: K
authors.lastname: Dietzmann
mesh_terms: D000328:Adult; D018450:Disease Progression; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008297:Male; D009778:Occipital Lobe / Q000473:pathology*; D013344:Subacute Sclerosing Panencephalitis / Q000175:diagnosis* / Q000503:physiopathology