Leptin signalling.
The identification of leptin as the product of the obesity (ob) gene has been followed by extensive research identifying a wide spectrum of physiological effects elicited by this adipose-derived hormone. These effects are mediated via a family of cytokine-like receptor isoforms distributed in both the central nervous system and periphery. The signal transduction pathways regulated by leptin are diverse and include those characteristic of both cytokine and growth factor receptor signalling. This review describes the structure and function of leptin receptors and summarizes recent progress that has been made in characterizing the increasing number of signal transduction pathways regulated by leptin.
Sweeney
Gary
G
Department of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada M3J 1P3. gsweeney@yorku.ca
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000818:Animals; D047908:Intracellular Signaling Peptides and Proteins; D020738:Leptin / Q000502:physiology*; D020935:MAP Kinase Signaling System; D009569:Nitric Oxide / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000502:physiology*; D054411:Receptors, Leptin; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D015105:3',5'-Cyclic-AMP Phosphodiesterases; D047908:Intracellular Signaling Peptides and Proteins; D020738:Leptin; D009569:Nitric Oxide; D019869:Phosphatidylinositol 3-Kinases; D010750:Phosphoproteins; D017346:Protein Serine-Threonine Kinases; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases; D011506:Proteins; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D020741:rho GTP-Binding Proteins