Anti-insulin-like growth factor-1 autoantibodies in type 1 diabetes.
Insulin-like growth factor-1 (IGF-1) reportedly suppresses the development of type 1 diabetes in NOD mice, suggesting that IGF-1 is possibly a candidate for the autoantigens in type 1 diabetes. We therefore examined the anti-IGF-1 autoantibodies (IGF-1 Ab) in sera from patients with type 1 diabetes using radioimmunoassay. However, we were unable to demonstrate the existence of anti-IGF-1 autoantibodies in type 1 diabetes with our method. Further study is necessary to clarify whether anti-IGF-1 autoantibodies are existent in human type 1 diabetes and to determine the significance of IGF-1 in the pathogensesis of type 1 diabetes.
Maruyama
Taro
T
Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, 336-0002, Japan. taro-m@bd5.so-net.ne.jp
Murayama
Hiroshi
H
Nagata
Atsuo
A
Shimada
Akira
A
Kasuga
Akira
A
Saruta
Takao
T
D000328:Adult; D017668:Age of Onset; D001323:Autoantibodies / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D007334:Insulin-Like Growth Factor I