title: Remineralization effect of a low-concentration fluoride rinse in an intraoral model.
abstract: A previous study showed that a sodium hexafluorosilicate-calcium chloride-based two-solution fluoride (F) rinse containing 6 mmol/l of F was more effective than a 12 mmol/l F sodium fluoride rinse in depositing F on tooth surfaces and increasing oral F levels. The present study compared the remineralization effects of these two rinses in an intraoral de- and remineralization model. The results showed that the 6 mmol/l F two-solution rinse produced greater remineralization in increasing lesion mineral contents and reducing lesion depths. The results demonstrated that the effectiveness of an F regimen depends less on the F dose and more on the ability of the treatment to utilize F efficiently for remineralization.
authors.affiliation: American Dental Association Health Foundation, Paffenbarger Research Center, Polymers Division, National Institute of Standards and Technology, Gaithersburg, Md 20899, USA. laurence.chow@nist.gov
authors.forename: L C
authors.initials: LC
authors.lastname: Chow
authors.forename: S
authors.initials: S
authors.lastname: Takagi
authors.forename: S
authors.initials: S
authors.lastname: Frukhtbeyn
authors.forename: B A
authors.initials: BA
authors.lastname: Sieck
authors.forename: E E
authors.initials: EE
authors.lastname: Parry
authors.forename: N S
authors.initials: NS
authors.lastname: Liao
authors.forename: G E
authors.initials: GE
authors.lastname: Schumacher
authors.forename: M
authors.initials: M
authors.lastname: Markovic
mesh_terms: D000704:Analysis of Variance; D002122:Calcium Chloride / Q000627:therapeutic use; D002327:Cariostatic Agents / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008852:Microradiography; D008954:Models, Biological; D009067:Mouthwashes / Q000627:therapeutic use*; D012824:Silicic Acid / Q000627:therapeutic use*; D012969:Sodium Fluoride / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D002327:Cariostatic Agents; D004338:Drug Combinations; D009067:Mouthwashes; D012824:Silicic Acid; C004832:hexafluorosilicate; D012969:Sodium Fluoride; D002122:Calcium Chloride; D005459:Fluorides