title: Tiagabine-related non-convulsive status epilepticus in partial epilepsy: three case reports and a review of the literature.
abstract: There have been several recent reports of non-convulsive status epilepticus during tiagabine therapy in patients with partial epilepsy. We report three cases where elevation of tiagabine dosage was followed by electroclinical features, or electroencephalographic features without clinical signs, of non-convulsive status epilepticus. Administration of clonazepam and/or discontinuation to tiagabine lead to complete remission. In one case after re-exhibition of tiagabine the EEG again showed rhythmic delta waves. We review the other cases reported so far and discuss the different pathophysiological hypotheses about the association in the light of new experimental data.
authors.affiliation: Department of Neurology, University of Münster, Albert-Schweitzer-Strasse 33, 48129 Münster, Germany. kelling@uni-muenster.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Kellinghaus
authors.forename: Rainer
authors.initials: R
authors.lastname: Dziewas
authors.forename: Peter
authors.initials: P
authors.lastname: Lüdemann
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D004334:Drug Administration Schedule; D004828:Epilepsies, Partial / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D009557:Nipecotic Acids / Q000008:administration & dosage / Q000009:adverse effects*; D013226:Status Epilepticus / Q000139:chemically induced*; D000078308:Tiagabine
chemical_list: D000927:Anticonvulsants; D009557:Nipecotic Acids; D000078308:Tiagabine