title: Angiogenesis in bladder cancer--prognostic marker and target for future therapy.
abstract: Angiogenesis is the process by which tumours induce a blood supply, crucial for growth and metastasis. Evidence for its role in bladder carcinogenesis, its usefulness as a marker of patient prognosis, and potential anti-angiogenic therapies for future development are discussed in this chapter.
authors.affiliation: Imperial Cancer Research Fund Molecular Oncology Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK. e.streeter@icrf.icnet.uk
authors.forename: Edward H
authors.initials: EH
authors.lastname: Streeter
authors.forename: Adrian L
authors.initials: AL
authors.lastname: Harris
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000096:biosynthesis*; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D003510:Cyclohexanes; D004268:DNA-Binding Proteins; D004338:Drug Combinations; D016228:Endothelial Growth Factors / Q000096:biosynthesis; D006801:Humans; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008222:Lymphokines / Q000096:biosynthesis; D051379:Mice; D008819:Mice, Nude; D009389:Neovascularization, Pathologic / Q000150:complications* / Q000378:metabolism; D009687:Nuclear Proteins; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D010880:Piperidines; D011799:Quinazolines / Q000008:administration & dosage; D052999:Quinazolinones; D012717:Sesquiterpenes / Q000008:administration & dosage; D013939:Thymidine Phosphorylase / Q000378:metabolism; D014157:Transcription Factors; D001749:Urinary Bladder Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000628:therapy; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D043925:Angiogenesis Inducing Agents; D020533:Angiogenesis Inhibitors; D003510:Cyclohexanes; D004268:DNA-Binding Proteins; D004338:Drug Combinations; D016228:Endothelial Growth Factors; C497442:HIF1A protein, human; C497443:Hif1a protein, mouse; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008222:Lymphokines; D009687:Nuclear Proteins; D010880:Piperidines; D011799:Quinazolines; D052999:Quinazolinones; D012717:Sesquiterpenes; D014157:Transcription Factors; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D013939:Thymidine Phosphorylase; C010176:halofuginone; D000077609:O-(Chloroacetylcarbamoyl)fumagillol