Absolute risk or relative risk? A study of intraspecies and interspecies extrapolation of chemical-induced cancer risk.
We have used the CBDS database of the National Toxicology Program to study the difference between absolute risk and relative risk models for interspecies and intersex predictions of cancer risk. For no combination (class) of tumor and site is the prediction good for all chemicals. The variation in predicted risk between chemicals exceeds the difference in risks resulting from application of these two models. On the whole, it appears that relative risk is a better model.
Kuo
Jeanne
J
Department of Physics and Center for Risk Analysis, Harvard University, Cambridge, MA, USA.
Linkov
Igor
I
Rhomberg
Lorenz
L
Polkanov
Michael
M
Gray
George
G
Wilson
Richard
R
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity; D009369:Neoplasms / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D018570:Risk Assessment; D013045:Species Specificity
D002273:Carcinogens; D006843:Hydrocarbons, Chlorinated; D009153:Mutagens