title: Toxicity of adipic acid.
abstract: Adipic acid has very low acute toxicity in rats with an LD50 > 5000 mg/kg. Adipic acid produced mild to no skin irritation on intact guinea pig skin as a 50% concentration in propylene glycol; it was not a skin sensitizer. Adipic acid caused mild conjunctival irritation in washed rabbit eyes; in unwashed rabbit eyes, there was mild conjunctival irritation, minimal iritis, but no corneal effects. Adipic acid dust may irritate the mucous membranes of the lungs and nose. In a 2-year feeding study, rats fed adipic acid at concentrations up to 5% in the diet exhibited only weight loss. Adipic acid is not genetically active in a wide variety of assay systems. Adipic acid caused no developmental toxicity in mice, rats, rabbits, or hamsters when administered orally. Adipic acid is partially metabolized in humans; the balance is eliminated unchanged in the urine. Adipic acid is slightly to moderately toxic to fish, daphnia, and algae in acute tests.
authors.affiliation: Haskell Laboratory, DuPont Company, 1090 Elkton Road, Newark, DE 19714, USA.
authors.forename: Gerald L
authors.initials: GL
authors.lastname: Kennedy
mesh_terms: D000272:Adipates / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D017753:Ecosystem; D004785:Environmental Pollutants / Q000633:toxicity; D005503:Food Additives / Q000633:toxicity*; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D016273:Occupational Exposure; D011817:Rabbits; D051381:Rats; D018675:Toxicity Tests
chemical_list: D000272:Adipates; D004785:Environmental Pollutants; D005503:Food Additives; C029900:adipic acid