title: Expression of nerve growth factor during the development of nervous system in early chick embryo.
abstract: In the chick gastrula, nerve growth factor (NGF) is localized to the endoblast mesoblast presumptive head ectoderm but not in the presumptive neuroectoblast. During early morphogenesis the dorsal body ectoderm presumptive neural crest cells exhibit strong NGF positive cell surface reaction. NGF appears to be a marker of cells participating in morphogenetic movements but not early neural differentiation. NGF is localized where neural folds fuse and cells die allowing detachment of the neural tube from head ectoderm as well as in dead cells in the neurocoele. NGF reactivity in cells lining the evaginated extremities of the optic vesicle the floor of the neural tube the splanchnopleure heart primordia the inner outer surfaces of somites is suggestive of the role of NGF in primitive organ shaping.
authors.affiliation: Molecular Embryology Laboratory, Department of Zoology, University of Pune, Pune 411 007, India. shobhabhargava@hormail.com
authors.forename: Shobha
authors.initials: S
authors.lastname: Bhargava
authors.forename: S P
authors.initials: SP
authors.lastname: Modak
mesh_terms: D000818:Animals; D016923:Cell Death / Q000502:physiology; D002642:Chick Embryo; D005775:Gastrula / Q000166:cytology; D018507:Gene Expression Regulation, Developmental; D006257:Head / Q000196:embryology; D020932:Nerve Growth Factor / Q000235:genetics*; D009420:Nervous System / Q000166:cytology / Q000196:embryology*; D009474:Neurons / Q000166:cytology
chemical_list: D020932:Nerve Growth Factor