title: Atrophy of the basal ganglia as the initial diagnostic sign of germinoma in the basal ganglia.
abstract: Germ-cell tumors of the central nervous system generally develop in the midline, but the tumors can also occur in the basal ganglia and/or thalamus. However, MR images have rarely been documented in the early stage of the tumor in these regions. We retrospectively reviewed MR images obtained on admission and approximately 3 years earlier in two patients with germinoma in the basal ganglia, and compared them with CT. In addition to hyperdensity on CT, both hyperintensity on T1-weighted images and a small hyperintense lesion on T2-weighted images were commonly seen in the basal ganglia. These findings may be early MRI signs of germinoma in this region, and the earliest and most characteristic diagnostic feature on MRI was atrophy of the basal ganglia, which was recognizable before development of hemiparesis.
authors.affiliation: Department of Radiology, Niigata University Faculty of Medicine, 1-757 Asahimachi-dori, Japan. nradioko@med.niigata-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Okamoto
authors.forename: J
authors.initials: J
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
authors.forename: K
authors.initials: K
authors.lastname: Morii
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Tokiguchi
authors.forename: T
authors.initials: T
authors.lastname: Furusawa
authors.forename: K
authors.initials: K
authors.lastname: Sakai
mesh_terms: D000293:Adolescent; D001284:Atrophy / Q000175:diagnosis; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000473:pathology*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D018237:Germinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography; D012189:Retrospective Studies