Association of a novel single nucleotide polymorphism of the prostacyclin synthase gene with myocardial infarction.
BACKGROUND
Myocardial infarction (MI) is a complex multifactorial and polygenic disorder that is thought to result from an interaction between an individual's genetic makeup and various environmental factors. The purpose of this study was to investigate the association between a novel single nucleotide polymorphism in the prostacyclin synthase gene and MI.


RESULTS
By the use of polymerase chain reaction-single-strand conformation polymorphism analysis, we identified a single nucleotide polymorphism, C1117A, in exon 8. This nucleotide change did not cause an amino acid change in codon 373. We performed an association study of the polymorphism in 138 patients and 130 healthy control subjects. Multiple logistic linear regression analysis showed the genotype distributions were significantly different between the control group and the MI group (odds ratio, 2.12; 95% CI, 1.47-3.05, P =.04). The C/C genotype was found more frequently in the MI group than in the control group.


CONCLUSIONS
We conclude that the C1117A polymorphism in exon 8 is associated with risk for MI and may be a genetic marker of MI in Japanese persons.
Nakayama
Tomohiro
T
Division of Receptor Biology, Advanced Medical Research Center, and the 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan. tnakayam@med.nihon-u.ac.jp
Soma
Masayoshi
M
Saito
Satoshi
S
Honye
Junko
J
Yajima
Junji
J
Rahmutula
Dolkun
D
Kaneko
Yukie
Y
Sato
Mikano
M
Uwabo
Jiro
J
Aoi
Noriko
N
Kosuge
Kotoko
K
Kunimoto
Masako
M
Kanmatsuse
Katsuo
K
Kokubun
Shinichiro
S
D016022:Case-Control Studies; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D015342:DNA Probes; D005260:Female; D005838:Genotype; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012044:Regression Analysis; D012307:Risk Factors
D015342:DNA Probes; D003577:Cytochrome P-450 Enzyme System; D019746:Intramolecular Oxidoreductases; C022461:prostacyclin synthetase