title: Inhibition of alpha-glucosidase by oleanolic acid and its synthetic derivatives.
abstract: Oleanolic acid (1) and five synthetic derivatives (2-6) were tested spectrophotometrically for inhibition of urease, beta-lactamase, acetyl cholinesterase and alpha-glucosidase. All products showed a positive response only against alpha-glucosidase but not against the other enzymes; IC(50) calculations showed that the dihydroxy-olide derivative (4) was the most potent among all tested samples.
authors.affiliation: H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan. shaiq303@hotmail.com
authors.forename: Muhammad Shaiq
authors.initials: MS
authors.lastname: Ali
authors.forename: Muhammad
authors.initials: M
authors.lastname: Jahangir
authors.forename: Syed Shazad ul
authors.initials: SS
authors.lastname: Hussan
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D009828:Oleanolic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D009828:Oleanolic Acid