title: Colloid infusion in the perinatal period and abnormal neurodevelopmental outcome in very low birth weight infants.
abstract: In very low birth weight (VLBW) infants, colloid infusion is associated with impaired perinatal lung function and increased oxygen dependency duration. The aim of this study was to determine whether perinatal colloid infusion was associated with abnormal neurodevelopmental outcome. All perinatal fluid input (crystalloid and colloid) given to VLBW infants entered into a randomised trial was recorded. At 1 and/or 2 years, the neurodevelopmental status of VLBW infants was routinely assessed. Of 131 survivors, median gestational age 27 weeks (range 23-33 weeks), 95 were seen at follow-up. Nineteen had abnormal neurodevelopmental outcome and differed significantly from the rest of the cohort with regard to their birth weight, magnitude of colloid infusion received and the proportions who had received postnatal steroids, suffered prolonged oxygen dependency or having had intracerebral haemorrhage/periventricular leucomalacia development. Regression analysis demonstrated that only colloid infusion related significantly to abnormal neurodevelopmental outcome independent of other variables.
  
  
  CONCLUSIONS
  These data suggest that colloid infusion should be used with caution in the perinatal period.
authors.affiliation: Department of Child Health, Guy's, King's and St Thomas' School of Medicine, King's College Hospital, London SE5 9RS, United Kingdom. anne.greenough@kcl.ac.uk
authors.forename: Anne
authors.initials: A
authors.lastname: Greenough
authors.forename: Paul
authors.initials: P
authors.lastname: Cheeseman
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Kavvadia
authors.forename: Gabriel
authors.initials: G
authors.lastname: Dimitriou
authors.forename: Margaret
authors.initials: M
authors.lastname: Morton
mesh_terms: D001921:Brain / Q000254:growth & development*; D003102:Colloids / Q000627:therapeutic use*; D002658:Developmental Disabilities / Q000503:physiopathology*; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D016896:Treatment Outcome
chemical_list: D003102:Colloids