Organochlorine pesticides and chlorinated hydrocarbon solvents in the blood of chemically sensitive patients [corrected]. A statistical comparison with therapeutic medication and natural hormones.
The blood levels of organochlorine pesticides and chlorinated hydrocarbon solvents were measured in 200 and 114 chemically sensitive patients respectively, and compared with blood concentrations of standard medication (non- chlorinated substances. Clonidine, Haloperidol) of comparable toxicity after therapeutically effective dosage, and with reference levels of highly potent chemicals in the blood such as hormones. It was shown that the average blood levels of the most toxic environmental pollutants are comparable with the therapeutic steady state average blood levels of medications which have similar toxicities in the animal model. In addition the toxicity levels of xenoestrogens are at least an order of magnitude higher than normal plasma estrogen or progesterone levels. These findings suggest the possibility of additive or synergistic effects of these chlorinated compounds and the aforementioned medications. Also, these findings suggest the possibility of hormone deregulation from exposure to the aforementioned toxic chlorinated compounds.
Rea
W J
WJ
Environmental Health Center-Dallas, Texas 75231, USA. wjr@ehcd.com
Fenyves
E J
EJ
Seba
D
D
Pan
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004347:Drug Interactions; D004967:Estrogens / Q000097:blood / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000009:adverse effects / Q000097:blood*; D007223:Infant; D007306:Insecticides / Q000009:adverse effects / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018777:Multiple Chemical Sensitivity / Q000209:etiology*; D011374:Progesterone / Q000097:blood / Q000627:therapeutic use; D012997:Solvents / Q000009:adverse effects / Q000032:analysis*; D015262:Xenobiotics / Q000009:adverse effects / Q000097:blood
D004967:Estrogens; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D012997:Solvents; D015262:Xenobiotics; D011374:Progesterone