title: Iodine-123-metaiodobenzylguanidine scintigraphy of total cardiac adrenergic denervation in Brugada syndrome.
abstract: A 22-year-old Japanese man with Brugada syndrome was resuscitated from cardiopulmonary arrest. In addition to the electrocardiographic evidence of the syndrome and the absence of apparent structural heart disease, no accumulation of iodine-123-metaiodobenzylguanidine (MIBG) was found anywhere throughout the heart. Thallium-201 (Tl) single photon emission computed tomography (SPECT) distribution showed no significant decrease in its uptake. To our knowledge, this is the first report that has demonstrated a homogeneous absence of cardiac accumulation of MIBG in Brugada syndrome.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
authors.forename: Naotsugu
authors.initials: N
authors.lastname: Oyama
authors.forename: Noriko
authors.initials: N
authors.lastname: Oyama
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yokoshiki
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Satoh
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Katoh
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hayashi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Miyasaka
authors.forename: Akira
authors.initials: A
authors.lastname: Kitabatake
mesh_terms: D019797:3-Iodobenzylguanidine; D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000000981:diagnostic imaging*; D002037:Bundle-Branch Block / Q000000981:diagnostic imaging*; D004562:Electrocardiography; D006321:Heart / Q000000981:diagnostic imaging* / Q000294:innervation*; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D019275:Radiopharmaceuticals; D013577:Syndrome; D015899:Tomography, Emission-Computed, Single-Photon; D014693:Ventricular Fibrillation / Q000175:diagnosis*
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine