[Transient erythroblastopenia in the context of Epstein-Barr virus infection].
The authors report the case of a previously healthy 5-year-old boy who, 1 month after tonsillitis, presented severe aregenerative anemia, macrocytosis, and increased hemoglobin F associated with mild thrombocytopenia. Peripheral blood smear showed no significant alterations and bone marrow aspirate revealed markedly decreased red blood cell precursors. Etiological investigation showed elevated titers of Epstein-Barr virus antibodies (IgM anti-viral capsid antigen). Bone marrow biopsy showed no criteria for red cell aplasia and in situ hybridization revealed intracellular Epstein-Barr virus. Reticulocytosis emerged from days 10-17 of follow-up, together with rising hemoglobin. Mean corpuscular volume and hemoglobin F returned to normal 2 months later. Immunological study revealed partial IgG3 deficit that persisted after 1 year of follow-up.
Sameiro Barreirinho
M
M
Servicio de Hematología.Hospital de CrianCas Maria Pia. Porto. Portugal.
Lopes Guerra
M
M
Sousa Costa
E
E
Manuel Couceiro
A
A
Rodrigues Neves
E
E
Morais Barbot
J
J
D000740:Anemia / Q000821:virology*; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D004900:Erythroblasts; D006801:Humans; D008297:Male