Tandem DNA binding of E. coli's transactivator PhoB.
In this issue of Structure, Blanco et al. describe the first structure of a two-component response regulator effector domain bound to its target DNA, showing novel tandem binding to successive direct repeat sequences of pho boxes from the phoA operon promotor.
Volz
Karl
K
D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry*; D019281:Dimerization; D029968:Escherichia coli Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D014157:Transcription Factors / Q000737:chemistry
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D014157:Transcription Factors; C061278:PhoB protein, Bacteria