Anti-lipid-peroxidative principles from Tournefortia sarmentosa.
Using the inhibition of Cu(2+)-induced low-density-lipoprotein (LDL) peroxidation to direct fractionation, four new benzenoids, tournefolal (1), tournefolic acids A (2) and B (3), and B ethyl ester (4), together with salvianolic acid A (5), isosalvianolic acid C (6), lithospermic acid (7), salvianolic acid F (8), and rosmarinic acid (9), were isolated from the stems of Tournefortia sarmentosa. The structures of the new compounds 1-4 were elucidated on the basis of spectral and chemical methods. Furthermore, the anti-LDL-peroxidative activity of the isolated compounds was determined. All isolated compounds exhibited more potent activity than probucol except for salvianolic acid F (8).
Lin
Yun-Lian
YL
National Research Institute of Chinese Medicine, Taipei 112, Taiwan. yllin@cma23.nricm.edu.tw
Chang
Ying-Ying
YY
Kuo
Yueh-Hsiung
YH
Shiao
Ming-Shi
MS
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001555:Benzene Derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028082:Boraginaceae / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D003300:Copper / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000378:metabolism*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D010545:Peroxides / Q000378:metabolism; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan
D000975:Antioxidants; D001555:Benzene Derivatives; D000960:Hypolipidemic Agents; D008077:Lipoproteins, LDL; D010545:Peroxides; D003300:Copper