title: Skin cleansers: three test protocols for the assessment of irritancy ranking.
abstract: In this article, the results of 3 studies on 2 hand cleansers (products A and B) are analysed. Three different test models (the patch test, the forearm wash test and the use test) are used to obtain information on the skin irritancy of these 2 products. Test reactivity was assessed by clinical scores and bioengineering methods such as corneometry for skin moisture, transepidermal water loss measurements for barrier function and chromametry for erythema. A correlating trend of product A being more aggressive than product B could be confirmed in all 3 studies and was statistically significant in the patch-testing series. Distinction of the results was dependent on the test protocol employed. Models for testing cleansing preparations should be chosen carefully, depending on the hypothesis to be evaluated.
authors.affiliation: Department of Dermatology, Friedrich Schiller University, Jena, Germany. spoo@derma.uni-jena.de
authors.forename: Julia
authors.initials: J
authors.lastname: Spoo
authors.forename: Walter
authors.initials: W
authors.lastname: Wigger-Alberti
authors.forename: Undine
authors.initials: U
authors.lastname: Berndt
authors.forename: Tobias
authors.initials: T
authors.lastname: Fischer
authors.forename: Peter
authors.initials: P
authors.lastname: Elsner
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000009:adverse effects*; D017453:Dermatitis, Irritant / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008297:Male; D010328:Patch Tests; D011336:Probability; D011446:Prospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
chemical_list: D000891:Anti-Infective Agents, Local