Mitochondria: regulating the inevitable.
Apoptosis is a form of programmed cell death important in the development and tissue homeostasis of multicellular organisms. Abnormalities in cell death control can lead to a variety of diseases, including cancer and degenerative disorders. Hence, the process of apoptosis is tightly regulated through multiple independent signalling pathways that are initiated either from triggering events within the cell or at the cell surface. In recent years, mitochondria have emerged as the central components of such apoptotic signalling pathways and are now known to control apoptosis through the release of apoptogenic proteins. In this review we aim to give an overview of the role of the mitochondria during apoptosis and the molecular mechanisms involved.
Parone
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PA
Departement de Biologie Cellulaire, University of Geneva, 30, quai E.-Ansermet, 1211 Geneva 4, Switzerland. Philippe.Parone@cellbio.unige.ch
James
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Martinou
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D017209:Apoptosis / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D020169:Caspases / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000502:physiology; D003574:Cytochrome c Group / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008928:Mitochondria / Q000502:physiology*; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D024101:Mitochondrial Proteins / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D015398:Signal Transduction
D003574:Cytochrome c Group; D007473:Ion Channels; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D024101:Mitochondrial Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D020169:Caspases; D002118:Calcium