title: Prevalence of HIV co-receptor polymorphisms in HIV-infected patients and uninfected volunteers in Luxembourg.
abstract: OBJECTIVE
  To describe the prevalence of nine HIV-1 co-receptor polymorphisms in Luxembourg (CCR5-Delta 32, CCR5-58755-A/G, CCR5m303, CCR5-59029-A/G, CCR2-64I, CCR5-59653-C/T, CX(3) CR1-V249I, CX(3) CR1-T280M, and SDF1-3'A) in 288 HIV-1-infected patients and in 158 uninfected, healthy volunteers.
  
  
  METHODS
  The presence of mutations was detected using PCR-restriction fragment length polymorphism (RFLP)-based methods.
  
  
  RESULTS
  We did not find any significant differences in genotype distributions and allele frequencies between infected and uninfected participants in Luxembourg. The distribution of genotypes agreed in all groups with Hardy-Weinberg predicted proportions. CCR5-Delta 32 was significantly associated with HIV-1-infected slow progressor patients.
  
  
  CONCLUSIONS
  Overall, allele frequencies were comparable to frequencies reported in previous studies in Caucasian populations.
authors.affiliation: Laboratoire de Rétrovirologie, Centre de Recherche Public - Santé, Centre Hospitalier de Luxembourg, Luxembourg. roman.f@retrovirology.lu
authors.forename: François
authors.initials: F
authors.lastname: Roman
authors.forename: Nathalie
authors.initials: N
authors.lastname: Franck
authors.forename: Catherine
authors.initials: C
authors.lastname: Burgy
authors.forename: Jean
authors.initials: J
authors.lastname: Servais
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Zimmer
authors.forename: Joël
authors.initials: J
authors.lastname: Mossong
authors.forename: Patrick
authors.initials: P
authors.lastname: Goubau
authors.forename: François
authors.initials: F
authors.lastname: Schneider
authors.forename: Robert
authors.initials: R
authors.lastname: Hemmer
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Schmit
mesh_terms: D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D015331:Cohort Studies; D005858:Germany / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology* / Q000235:genetics; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence; D019713:Receptors, CCR5 / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D019713:Receptors, CCR5