title: Demonstration of dose response of flurbiprofen lozenges with the sore throat pain model.
abstract: The dose response of flurbiprofen lozenges (2.5, 5.0, and 12.5 mg) was evaluated in the treatment of sore throat. A refined version of the sore throat pain model showed that 12.5 mg flurbiprofen was significantly more effective than placebo at providing total pain relief and reducing throat soreness (p <.05). Flurbiprofen, 5.0 mg, was more effective than placebo for the reduction of throat soreness and the sensation of throat swelling (P <.05). The 2.5-mg flurbiprofen lozenge was indistinguishable from placebo. For every milligram of increase in the dose of flurbiprofen, there was an approximately 0.3-unit increase in total pain relief (P <.05). Flurbiprofen lozenges in all 3 dosages were well tolerated. Flurbiprofen lozenges are effective for sore throat at a dose between 5.0 mg and 12.5 mg; the sore throat pain model is a sensitive assay for demonstration of the dose-response relationship of an analgesic agent.
authors.affiliation: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Bernard P
authors.initials: BP
authors.lastname: Schachtel
authors.forename: Harvey D
authors.initials: HD
authors.lastname: Homan
authors.forename: Iain A
authors.initials: IA
authors.lastname: Gibb
authors.forename: Jenny
authors.initials: J
authors.lastname: Christian
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D010147:Pain Measurement / Q000187:drug effects / Q000706:statistics & numerical data; D010612:Pharyngitis / Q000188:drug therapy*
chemical_list: D000700:Analgesics; D005480:Flurbiprofen