Control of T cell function by positive and negative regulators.
T cells are an essential element of the body's immune system. Engagement of the T cell receptor is responsible for initiating the signaling events that can activate, inactivate, or eliminate T cells, depending on the magnitude and duration of the signal. Control of T cell signaling occurs through both positive and negative regulation, as well as through the actions of molecular scaffolds that contribute to the formation of signaling complexes. The T Cell Signal Transduction Pathway at the STKE Connections Maps highlights the molecular components that are responsible for T cell activation. Understanding the mechanisms that regulate T cell responsiveness will aid in the development of therapeutic agents to treat infection, cancer, and autoimmune disease and immune deficiency.
Singer
Andrew L
AL
The Abramson Family Cancer Research Institute, Department of Laboratory Medicine and Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA. koretzky@mail.med.upenn.edu
Koretzky
Gary A
GA
D000818:Animals; D006801:Humans; D008213:Lymphocyte Activation; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000378:metabolism; D018448:Models, Immunological; D010766:Phosphorylation; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism*; D015290:Second Messenger Systems; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D011948:Receptors, Antigen, T-Cell; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)