Antioxidative activity of green tea polyphenol in cholesterol-fed rats.
This study investigated the effects of green tea polyphenol on the serum antioxidative activity and cholesterol levels of cholesterol-fed rats and compared them with those of probucol, an antioxidant hypocholesterolemic agent. To evaluate the antioxidative activity, the susceptibility to oxidative modification of low-density lipoprotein (LDL) isolated from the serum of cholesterol-fed rats was measured, as was the serum antioxidative activity using the spontaneous autoxidation system of brain homogenate. Administration of green tea polyphenol effectively inhibited LDL oxidation and elevated serum antioxidative activity to the same degree as probucol. However, higher amounts of polyphenol than probucol needed to be administered to reduce the total, free, and LDL cholesterol levels. Furthermore, green tea polyphenol increased the levels of high-density lipoprotein (HDL) cholesterol, leading to dose-dependent improvement of the atherogenic index, an effect that was not seen with probucol. Thus, green tea polyphenol may exert an antiatherosclerotic action by virtue of its antioxidant properties and by increasing HDL cholesterol levels.
Yokozawa
Takako
T
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan. yokozawa@ms.toyoma-mpu.ac.jp
Nakagawa
Takako
T
Kitani
Kenichi
K
D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D016632:Apolipoprotein A-I / Q000097:blood; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D005419:Flavonoids; D015227:Lipid Peroxidation / Q000187:drug effects*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D010084:Oxidation-Reduction; D010636:Phenols / Q000494:pharmacology*; D011108:Polymers / Q000494:pharmacology*; D059808:Polyphenols; D011341:Probucol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000737:chemistry*
D000975:Antioxidants; D016632:Apolipoprotein A-I; D002791:Cholesterol, Dietary; D005419:Flavonoids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D013662:Tea; D002784:Cholesterol; D011341:Probucol