title: [Increased expression of monocytic cell adhesion molecules and formation of monocyte-thrombocyte aggregates in coronary restenosis].
abstract: OBJECTIVE
  To examine expression of superficial antigens by blood monocytes and granulocytes as well as the number of leukocyte-platelet complexes forming in in vitro activation in patients subjected to coronary angioplasty; to analyse changes in these parameters in coronary restenosis.
  
  
  METHODS
  Membrane expression of leukocytic antigens and the number of leukocyte-platelet complexes after activation in the whole blood were measured by direct immunofluorescence and flow cytometry in 24 patients who have undergone stenting of coronary arteries. 14 of them had angiographically confirmed restenosis.
  
  
  RESULTS
  The tests discovered high expression of integrins Mac-1 and VLA-4 by monocytes and elevated relative number of monocyte-platelet complexes in patients with restenosis vs those free of stenosis (1425 +/- 76 and 1195 +/- 71 r.u. for Mac-1, 87 +/- 7 and 65 +/- 6 r.u. for VLA-4, 47 +/- 4 and 29 +/- 3%, respectively, for monocyte-platelet complexes; p < 0.05 for all the indices).
  
  
  CONCLUSIONS
  Coronary restenosis may result from elevated expression of adhesion molecules by monocytes manifest in activation of the cells in vitro.
authors.forename: T I
authors.initials: TI
authors.lastname: Aref'eva
authors.forename: S I
authors.initials: SI
authors.lastname: Provatorov
authors.forename: A N
authors.initials: AN
authors.lastname: Samko
authors.forename: L V
authors.initials: LV
authors.lastname: Baĭdun
authors.forename: T L
authors.initials: TL
authors.lastname: Krasnikova
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001792:Blood Platelets; D015815:Cell Adhesion Molecules / Q000097:blood*; D002449:Cell Aggregation; D023903:Coronary Restenosis / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D015815:Cell Adhesion Molecules