Glucose-insulin-potassium solution for acute myocardial infarction.
OBJECTIVE
To review the role of glucose-insulin-potassium (GIK) solution in the management of acute myocardial infarction (AMI).


METHODS
MEDLINE (1966-October 2001) database, using the search terms glucose, insulin, potassium, and myocardial infarction.


METHODS
Relevant English-language human studies and meta-analyses.


RESULTS
Most studies that have investigated the use of GIK in AMI have been from the prethrombolytic era. Although most data trended toward favoring GIK in improving mortality and morbidity of AMI, the Polish GIK study was terminated prematurely because of an increase in mortality in patients treated with GIK. Dosage, duration of treatment, and route of administration of GIK varied among studies.


CONCLUSIONS
Until results from larger-scale studies become available, the routine use of GIK infusion in AMI patients is not recommended.
Janiger
Jeffrey L
JL
Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, New York, NY, USA.
Cheng
Judy W M
JW
D002986:Clinical Trials as Topic; D000075202:Contraindications; D004338:Drug Combinations; D005947:Glucose / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality; D011188:Potassium / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D004338:Drug Combinations; D007328:Insulin; C030396:glucose-insulin-potassium cardioplegic solution; D005947:Glucose; D011188:Potassium