[PPARgamma and atheroma].
PPARs (peroxisome proliferator-activated receptors) are members of the nuclear receptor family. They regulate the transcription of target genes involved in lipid and lipoprotein metabolism, glucose homeostasis and cell differentiation (particularly adipogenesis). Recent studies have clearly shown a role for PPARs in the arterial wall, where they interact with several processes involved in the development and progression of atherosclerosis, particularly with respect to macrophage foam cell formation and the transcriptional regulation of genes mediating the inflammatory response.
Staels
B
B
INSERM UR 545 - Département d'Athérosclérose, Institut Pasteur et faculté de Pharmacie, Université de Lille II, F - 59019 Lille Cedex.
D001161:Arteriosclerosis / Q000503:physiopathology*; D001786:Blood Glucose / Q000502:physiology; D002454:Cell Differentiation; D005487:Foam Cells / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism; D008954:Models, Biological; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic
D001786:Blood Glucose; D008074:Lipoproteins; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors