[Adaptation of synaptic transmission to high concentrations of homocysteinic acid].
Prolonged incubation with 25 microM homocysteine acid led to initial suppression of the synaptic transmission, which in 6 out of 12 cases was followed by the restoration of the population spike to values 63% from the control. In the rest of experiments, a transient decrease of the population spike amplitude was observed during wash-out of homocysteine acid. Such a pattern suggests that synaptic transmission has special mechanisms for adaptation to increasing concentrations of the excitatory amino acids which are potentially damaging.
Boĭchuk
Ia A
IaA
Bogomolets Institute of Physiology, NAS of Ukraine, Kyiv. mb@serv.biph.kiev.ua
Kopanytsia
M V
MV
Lozova
N O
NO
D000200:Action Potentials; D000222:Adaptation, Physiological; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006710:Homocysteine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D006710:Homocysteine; C007956:homocysteic acid