title: Complicated nosocomial pneumonia due to Legionella pneumophila in an immunocompromised child.
abstract: An immunocompromised child developed necrotizing pneumonia with BAL cultures growing Legionella pneumophila resistant to treatment, including erythromycin and rifampicin. Ciprofloxacin and clarithromycin reversed the clinical course; their use as first-line drugs is justifiable and a high index of suspicion for the occurrence of legionellosis is warranted.
authors.affiliation: Department of Pediatrics, Private University of Witten/Herdecke, Wuppertal, Germany. hubert.trubel@yale.edu
authors.forename: Hubert K F
authors.initials: HK
authors.lastname: Trübel
authors.forename: Heinz G W
authors.initials: HG
authors.lastname: Meyer
authors.forename: Bernhard
authors.initials: B
authors.lastname: Jahn
authors.forename: Markus
authors.initials: M
authors.lastname: Knuf
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kamin
authors.forename: Ralf G
authors.initials: RG
authors.lastname: Huth
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002675:Child, Preschool; D002939:Ciprofloxacin / Q000627:therapeutic use; D017291:Clarithromycin / Q000627:therapeutic use; D003428:Cross Infection / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D016867:Immunocompromised Host; D016952:Legionella pneumophila / Q000302:isolation & purification*; D007877:Legionnaires' Disease / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D009748:Nutrition Disorders / Q000150:complications; D018410:Pneumonia, Bacterial / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D017291:Clarithromycin