title: [Genetic alterations of transcription cofactors in solid tumors].
abstract: Many hormones exert their effects through specific nuclear receptors which belong to a superfamily of ligand-activated transcription factors. These receptors control target gene expression through the recruitment of different cofactors acting as transcription activation or repression mediators, generally as parts of multiprotein complexes. The importance and the role in physiopathology of these different cofactors only begin to be defined. Different types of alterations affecting genes coding nuclear receptor transcription cofactors have indeed been described in cancer. The most important examples are gene amplification that leads to overexpression and gene mutations or translocations introducing qualitative modifications. This paper aims at bringing together the corresponding literature and focuses on gene alterations observed in solid tumors.
authors.affiliation: Inserm U. 540, Endocrinologie moléculaire et cellulaire des cancers, 60, rue de Navacelles, 34090 Montpellier, France. v.cavailles@u540.montp.inserm.fr
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Rouayrenc
authors.forename: Audrey
authors.initials: A
authors.lastname: Castet
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Rey
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Brouillet
authors.forename: Pascal
authors.initials: P
authors.lastname: Pujol
authors.forename: Françoise
authors.initials: F
authors.lastname: Vignon
authors.forename: Thierry
authors.initials: T
authors.lastname: Maudelonde
authors.forename: Vincent
authors.initials: V
authors.lastname: Cavaillès
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics; D002868:Chromosomal Proteins, Non-Histone; D002869:Chromosome Aberrations; D004265:DNA Helicases; D004268:DNA-Binding Proteins / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005784:Gene Amplification; D019398:Genes, BRCA1; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics; D056921:Nuclear Receptor Coactivator 3; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D000071796:SMARCB1 Protein; D009626:Terminology as Topic; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic; D015533:Transcriptional Activation
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D004965:Estrogen Antagonists; D009687:Nuclear Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D056921:Nuclear Receptor Coactivator 3; C084108:SMARCA4 protein, human; D004265:DNA Helicases