[Celiac disease: clinical and subclinical forms].
Coeliac disease is an intolerance to gluten that classically produces a chronic diarrhoea with a picture of malabsorption and a total villous atrophy. These elements regress completely in a sequential way under a prolonged strict gluten-free diet. The progress registered in the understanding of this affection depends on the individualization of the atypical forms (delayed isolated stature, constipation...) of asymptomatic forms thanks to the study of specific antibodies (anti-gliadin, anti-endomysium, and more recently anti-transglutaminase). The auto-immune nature of coeliac disease is well established. The diagnostic criteria are simplified allowing the commencement of a gluten-free diet which must be perfectly detailed. Finally, allergy to wheat flour merits individualization in the framework of coeliac disease (cf. article).
Morali
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Hôpital d'Enfants, CHU Nancy-Brabois, Allée du Morvan, 54500 Vandoeuvre-les-Nancy.
D000293:Adolescent; D000328:Adult; D017951:Antigen Presentation; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000145:classification* / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology; D002446:Celiac Disease / Q000145:classification* / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology; D002648:Child; D015897:Comorbidity; D003967:Diarrhea / Q000209:etiology; D019204:GTP-Binding Proteins / Q000276:immunology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005903:Gliadin / Q000009:adverse effects; D005983:Glutens / Q000009:adverse effects; D006130:Growth Disorders / Q000209:etiology; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D008286:Malabsorption Syndromes / Q000209:etiology; D015995:Prevalence; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D012698:Serologic Tests / Q000592:standards; D011503:Transglutaminases / Q000276:immunology
D001323:Autoantibodies; D006683:HLA-DQ Antigens; D005983:Glutens; D005903:Gliadin; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins