title: Initial treatment with amphotericin B plus rifampin in the acute treatment of cryptococcal meningitis in aids.
abstract: The result of initial treatment with amphotericin B (0.7 mg/kg/day) plus rifampin (600 mg/day) for 2 weeks, followed by fluconazole (400 mg/day) for 8 weeks in the acute treatment of cryptococcal meningitis in AIDS is reported. There were 10 patients in the study: at 2 weeks, all had made a clinical response and cerebrospinal fluid was sterile in 4 patients; at 10 weeks, all had negative cerebrospinal fluid cultures. Serious side effects were not detected.
authors.affiliation: Department of Medicine, Faculty of Medicine, Khon Kaenk University, Thailand.
authors.forename: V
authors.initials: V
authors.lastname: Chotmongkol
authors.forename: K
authors.initials: K
authors.lastname: Methawasin
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000201:enzymology; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000188:drug therapy* / Q000201:enzymology; D012293:Rifampin / Q000008:administration & dosage*
chemical_list: D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D000666:Amphotericin B; D012321:DNA-Directed RNA Polymerases; D012293:Rifampin