title: Cardiac sympathetic dysinnervation in Type 2 diabetes mellitus with and without ECG-based cardiac autonomic neuropathy.
abstract: To evaluate the presence and extent of global and regional distributions of cardiac sympathetic dysinnervation in Type 2 diabetes mellitus I-123-metaiodobenzylguanidine (I-123-MIBG) scintigraphy was applied to 15 Type 2 (noninsulin-dependent) diabetic patients with ECG-based cardiac autonomic neuropathy (> or = two of five age-related cardiac reflex tests abnormal) and 15 clinically comparable Type 2 diabetic patients without ECG-based cardiac autonomic neuropathy. Myocardial perfusion abnormalities were excluded by 99 m-Tc-methoxyisobutylisonitrile (99 m-MIBI) scintigraphy. Both in Type 2 diabetic patients with and without, ECG-based autonomic neuropathy, only one patient (7%) was found to have a normal homogeneous uptake of I-123-MIBG compared to 14 patients (93%) with a reduced I-123-MIBG uptake. The uptake of I-123-MIBG in the posterior myocardium of diabetic patients was smaller than in the anterior, lateral, and septal myocardium (P< .001, P< .001, P< .001, respectively). Diabetic patients with ECG-based cardiac autonomic neuropathy demonstrated a more pronounced reduction of the posterior I-123-MIBG myocardial uptake than diabetic patients without (P< .01). The mean global and the anterior, lateral, septal, and apical myocardial I-123-MIBG uptake was comparable between the two groups. The uptake of the posterior myocardial region correlated with all indices of heart rate variation at rest and during deep breathing. A correlation between global or regional myocardial I-123-MIBG uptake and QT interval was not observed. The study demonstrates that cardiac sympathetic dysinnervation is common in Type 2 diabetes mellitus both with and without ECG-based cardiac autonomic neuropathy. In Type 2 diabetes mellitus, the posterior myocardium is predominantly affected and the extent of dysinnervation is more pronounced in the presence of ECG-based cardiac autonomic neuropathy.
authors.affiliation: Diabetes Research Institute, Third Medical Department, Academic Schwabing City Hospital, Munich, Germany. oliver.schnell@lrz.uni-muenchen.de
authors.forename: Oliver
authors.initials: O
authors.lastname: Schnell
authors.forename: Katja
authors.initials: K
authors.lastname: Hammer
authors.forename: Daniela
authors.initials: D
authors.lastname: Muhr-Becker
authors.forename: Anette- Gabriele
authors.initials: A
authors.lastname: Ziegler
authors.forename: Mayo
authors.initials: M
authors.lastname: Weiss
authors.forename: Klaus
authors.initials: K
authors.lastname: Tatsch
authors.forename: Eberhard
authors.initials: E
authors.lastname: Standl
mesh_terms: D019797:3-Iodobenzylguanidine / Q000493:pharmacokinetics; D017763:Autonomic Denervation; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000601:surgery*; D003929:Diabetic Neuropathies / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006321:Heart / Q000000981:diagnostic imaging / Q000294:innervation*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging / Q000601:surgery*; D014018:Tissue Distribution
chemical_list: D019797:3-Iodobenzylguanidine; D006442:Glycated Hemoglobin; D019275:Radiopharmaceuticals