title: Premenstrual syndrome.
abstract: Premenstrual syndrome (PMS) affects the quality of life of millions of women. The complexity and variety of clinical presentation together with the cyclic recurrence of affective and somatic symptoms increase the difficulty in understanding and treating the disease. The precise pathophysiology of PMS is still unknown, but it is increasingly believed that, in women with PMS, the sensitive equilibrium between sex-steroids and central neurotransmitters is altered. Several studies have been carried out to understand the origin of the syndrome and to discover new ways of treatment. This review summarizes the most accepted PMS theories and treatments currently available based on the results of the best-designed trials.
authors.affiliation: Reproductive Endocrinology and Infertility Program, Department of Obstetrics and Gynecology, University of Western Ontario, London, ON, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Gianetto-Berruti
authors.forename: V
authors.initials: V
authors.lastname: Feyles
mesh_terms: D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003276:Contraceptives, Oral / Q000627:therapeutic use; D003613:Danazol / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004032:Diet; D004232:Diuretics / Q000627:therapeutic use; D004965:Estrogen Antagonists / Q000627:therapeutic use; D015444:Exercise; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives; D006801:Humans; D008019:Life Style; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use; D008903:Minerals / Q000627:therapeutic use; D028321:Plant Preparations / Q000627:therapeutic use; D011293:Premenstrual Syndrome / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy; D011372:Progestins / Q000627:therapeutic use; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012106:Research; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D013148:Spironolactone / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D014151:Anti-Anxiety Agents; D003276:Contraceptives, Oral; D003613:Danazol; D004232:Diuretics; D004965:Estrogen Antagonists; D007987:Gonadotropin-Releasing Hormone; D000451:Mineralocorticoid Receptor Antagonists; D008903:Minerals; D028321:Plant Preparations; D011372:Progestins; D017367:Selective Serotonin Reuptake Inhibitors; D013148:Spironolactone; D014815:Vitamins