title: [Long-term 10-year outcome after chemonucleolysis for lumbar disc herniation].
abstract: OBJECTIVE
  We studied the efficacy of papaine for treatment of herniated discs at a mean 10-year follow-up and compared results with other series and other treatments.
  
  
  METHODS
  From an initial group of 160 patients, 96 patients, 53 men and 43 women, mean age 39 years, were selected for evaluation. These patients had 46 L4L5 herniations and 50 L5S1 herniations. All 96 patients were operated in the same department and received the same dose of papaine under the same anesthesia conditions. All patients were followed regularly to 3 months postoperatively then were reviewed 3 to 17 years after surgery. Inquiries were made about return to work, pain, and activity. Physical examination and x-rays were obtained for all patients.
  
  
  RESULTS
  There were no neurological complications in our series. Seventeen patients required a second procedure for sciatic pain. Most of the patients continued their normal occupational and social activities after papaine treatment, but many of them had chronic lumbar pain.
  
  
  CONCLUSIONS
  Our results were comparable with series reporting a similar long follow-up. Surgery is more efficient than papaine but long-term results are equivalent.
  
  
  CONCLUSIONS
  Chemopapaine treatment provided good long-term results in our patients, similar to surgery. Chemonucleolysis may be employed as first line treatment for young patients with non-excluded disc herniation with sciatic pain.
authors.affiliation: Département d'Orthopédie-Traumatologie, CHU Dupuytren, 2, rue A. Carrel, 87042 Limoges.
authors.forename: F
authors.initials: F
authors.lastname: Aribit
authors.forename: J L
authors.initials: JL
authors.lastname: Charissoux
authors.forename: J P
authors.initials: JP
authors.lastname: Arnaud
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002917:Chymopapain / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007404:Intervertebral Disc Chemolysis / Q000009:adverse effects; D007405:Intervertebral Disc Displacement / Q000188:drug therapy*; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D002917:Chymopapain