title: Chemokines, inflammation and Trypanosoma cruzi infection.
abstract: The inflammatory response that follows the infection with Trypanosoma cruzi is essential for host resistance to infection but is also responsible for the diverse pathology observed in Chagas disease. Here, we examine the stimuli and mechanisms underlying chemokine production following infection in vitro and in vivo, and the ability of chemokines to coordinate the influx of inflammatory and immune cells to the site of parasite infection, and to control T. cruzi growth.
authors.affiliation: Departmento Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, 31270-901, Belo Horizonte, MG, Brazil. mmtex@icb.ufmg.br
authors.forename: Mauro M
authors.initials: MM
authors.lastname: Teixeira
authors.forename: Ricardo T
authors.initials: RT
authors.lastname: Gazzinelli
authors.forename: João S
authors.initials: JS
authors.lastname: Silva
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000276:immunology* / Q000469:parasitology; D018925:Chemokines / Q000096:biosynthesis / Q000276:immunology*; D006801:Humans; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D014349:Trypanosoma cruzi / Q000254:growth & development / Q000276:immunology*
chemical_list: D018925:Chemokines