[Changes in blood rheological properties and erythrocyte osmotic resistance in activation of free radical processes].
Relationship between serum oxidation of different degree and micro- and macrorheology of the blood and modification of this relationship in the presence of antioxidant alpha-tocopherol were studied. Lipid peroxidation affects blood rheology and erythrocyte osmotic resistance. Erythrocytes are the first to react to increased activity of free radical oxidation and to exhaust their compensatory potential. Plasma viscosity remains stable in serum oxidation of different degree, and therefore erythrocytes are responsible for changes in blood rheology during intensification of free radical oxidation. Moreover, erythrocytes are functionally resistant to oxidative stress in malonic dialdehyde concentrations under 3.62 +/- 0.41 nM/ml. alpha-Tocopherol increases functional resistance of erythrocytes and maybe of protein components of the plasma to damaging action of free radicals.
Roĭtman
E V
EV
Dement'eva
I I
II
Azizova
O A
OA
Nikitina
N A
NA
Gagaeva
E V
EV
Lopukhin
Iu M
IuM
D000975:Antioxidants / Q000494:pharmacology; D001809:Blood Viscosity / Q000187:drug effects; D004912:Erythrocytes / Q000378:metabolism / Q000502:physiology*; D005609:Free Radicals / Q000378:metabolism; D018056:Hemorheology; D006801:Humans; D066298:In Vitro Techniques; D009997:Osmotic Pressure; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D024502:alpha-Tocopherol / Q000494:pharmacology
D000975:Antioxidants; D005609:Free Radicals; D024502:alpha-Tocopherol