The relationship of Campylobacter jejuni infection and the development of Guillain-Barré syndrome.
Campylobacter jejuni is recognized as the most common infectious agent associated with the development of Guillain-Barré syndrome. Available information on the complete genome sequence of C. jejuni NCTC 11168 has helped researchers to identify polysaccharide capsules as well as genetic mechanisms in the synthesis of ganglioside-like cell surface molecules in this bacteria. Toxins may contribute to the host's inflammatory response seen in Guillain-Barré syndrome.
Tsang
Raymond S W
RS
Central Nervous System Infection and Vaccine Preventable Bacterial Diseases Division, National Microbiology Laboratory, Population and Public Health Branch, Health Canada, Winnipeg, Manitoba, Canada. rtsang@hc-sc.gc.ca
D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology; D002169:Campylobacter Infections / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D016123:Campylobacter jejuni / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D000939:Epitopes / Q000276:immunology; D005732:Gangliosides / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans
D000942:Antigens, Bacterial; D000939:Epitopes; D005732:Gangliosides