Inhibitory effect of 1-benzyl-5[(C)-2,6-dimethyl-1,5-heptadienyl] imidazole (KK-42) on desert locust, Schistocerca gregaria forsk.
Imidazole compound KK-42 was tested for its inhibitory effect on Schistocerca gregaria. The compound caused 80% mortality after 19 days of treatment with 100 microg of KK-42/insect. It also caused the production of deformed adults at even lower doses. Ecdysteroid content, when estimated by RIA, declined due to KK-42 treatment in both haemolymph and ovaries of the insect. Reduction in ecdysteroid titer was maximum at 100 microg of KK-42/insect. The value estimated by RIA was 0.34 ng/pL haemolymph as compared to 0.97 ng/microL in case of controls. Similarly,ecdysteroid content of ovaries detected was 0.48 ng/mg in treated ones as compared to 0.61 ng/mg in controls. Histological studies, however, revealed no alteration in the ovarian tissues due to KK-42 treatment.
Kumari
A
A
Department of Zoology, University of Delhi, India.
Kumar
U
U
Agarwal
H C
HC
D000818:Animals; D005260:Female; D006110:Grasshoppers / Q000187:drug effects* / Q000502:physiology; D007093:Imidazoles / Q000494:pharmacology*; D007605:Juvenile Hormones / Q000494:pharmacology*; D009866:Oogenesis / Q000187:drug effects
D007093:Imidazoles; D007605:Juvenile Hormones; C063652:1-benzyl-5-(2,6-dimethyl-1,5-heptadienyl)imidazole