Effect of latanoprost on hair growth in the bald scalp of the stump-tailed macacque: a pilot study.
Latanoprost, a selective FP prostanoid receptor agonist used in the treatment of glaucoma, has a hypertrichotic side effect. Using the macaque model of androgenetic alopecia, we examined the effect of latanoprost on hair growth. Eight monkeys were divided into 2 groups; one group received a daily topical application of 50 microg/ml of latanoprost for 5 months; a control group had a daily application of vehicle. For an additional 3 months, 2 monkeys from each group were given 500 microg/ml latanoprost, while the remaining monkeys continued with the previous treatment. Hair growth was evaluated by monthly photographs and phototricho-graphic analysis. Fifty microg/ml of latanoprost caused minimal hair growth. Latanoprost at 500 microg/ml induced moderate to marked hair regrowth with 5-10% conversion of vellus hairs to intermediary or terminal hairs. The vehicle group showed no effect. Further evaluation of latanoprost as an agent for treatment of human androgenetic alopecia is indicated.
Uno
Hideo
H
Wisconsin Regional Primate Research Centre, School of Medicine, University of Wisconsin-Madison, USA. huno4@attbi.com
Zimbric
Michele L
ML
Albert
Daniel M
DM
Stjernschantz
Johan
J
D000287:Administration, Topical; D000505:Alopecia / Q000188:drug therapy*; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006197:Hair / Q000187:drug effects* / Q000254:growth & development*; D000077338:Latanoprost; D008251:Macaca; D008297:Male; D010865:Pilot Projects; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*; D011897:Random Allocation; D012016:Reference Values; D016896:Treatment Outcome
D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost