title: Natural history of enteroaggregative and enterotoxigenic Escherichia coli infection among US travelers to Guadalajara, Mexico.
abstract: The natural history of enteroaggregative Escherichia coli (EAEC) and enterotoxigenic E. coli (ETEC) infection was studied among 40 US travelers who provided weekly stool samples for 4 weeks after arrival in Mexico. At enrollment, 5 subjects were colonized by EAEC and 3 by ETEC. During the first 2 weeks after enrollment, 12 developed EAEC diarrhea, 7 developed ETEC diarrhea (5 with mixed EAEC/ETEC diarrhea), 13 had EAEC colonization, and 7 had ETEC colonization. During the third and fourth weeks, 4 experienced EAEC diarrhea, 2 experienced ETEC diarrhea (1 with mixed EAEC/ETEC diarrhea), 31 had EAEC colonization, and none had ETEC colonization. Plasmid DNA analysis showed a high degree of heterogeneity among EAEC isolates. Symptomatic EAEC infection occurred early after arrival in Guadalajara, Mexico, and was as common as ETEC infection. Asymptomatic EAEC infection was recurrent.
authors.affiliation: Center for Infectious Diseases, Medical School and School of Public Health, University of Texas-Houston, Houston, TX, USA.
authors.forename: Javier A
authors.initials: JA
authors.lastname: Adachi
authors.forename: Charles D
authors.initials: CD
authors.lastname: Ericsson
authors.forename: Zhi-Dong
authors.initials: ZD
authors.lastname: Jiang
authors.forename: Margaret W
authors.initials: MW
authors.lastname: DuPont
authors.forename: Sanjay R
authors.initials: SR
authors.lastname: Pallegar
authors.forename: Herbert L
authors.initials: HL
authors.lastname: DuPont
mesh_terms: D000293:Adolescent; D000328:Adult; D001422:Bacterial Adhesion; D001427:Bacterial Toxins / Q000096:biosynthesis*; D003967:Diarrhea / Q000382:microbiology / Q000503:physiopathology; D004768:Enterotoxins / Q000096:biosynthesis*; D004926:Escherichia coli / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000382:microbiology* / Q000503:physiopathology*; D029968:Escherichia coli Proteins; D005243:Feces / Q000382:microbiology; D006801:Humans; D008800:Mexico; D014195:Travel; D014481:United States
chemical_list: D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; C034151:heat stable toxin (E coli)