Oral FK 506 blood levels are elevated in pig short bowel model: further investigations with co-administration of an intestinal CYP3A4 inhibitor.
Sano
N
N
Department of Pediatric Surgery, Tohoku University School of Medicine, Sendai, Japan.
Nio
M
M
Ishii
T
T
Amae
S
S
Wada
M
M
Nishi
K
K
Endo
N
N
Hayashi
Y
Y
Ohi
R
R
D000284:Administration, Oral; D000714:Anastomosis, Surgical; D000818:Animals; D019540:Area Under Curve; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007082:Ileum / Q000601:surgery; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000201:enzymology; D007583:Jejunum / Q000601:surgery; D007654:Ketoconazole / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D008657:Metabolic Clearance Rate; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D012778:Short Bowel Syndrome / Q000201:enzymology / Q000276:immunology / Q000503:physiopathology* / Q000601:surgery*; D013552:Swine; D016559:Tacrolimus / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology
D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D006899:Mixed Function Oxygenases; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D007654:Ketoconazole; D016559:Tacrolimus