title: Effect of Hatakeshimeji (Lyophyllum decastes Sing.) Mushroom on serum lipid levels in rats.
abstract: The effect of Hatakeshimeji (Lyophyllum decastes Sing.) mushroom on serum lipid levels was investigated in rats. When the mushroom (fruit body) powder or its hotwater extract was added at a level of 10% to a cholesterol-containing diet, the serum total cholesterol levels of rats fed the fruit body or the hot-water extract were markedly lower than that of controls, though there was no significant difference in serum HDL-cholesterol among the three groups. On a cholesterol-free diet, the addition of fruit body powder at a level of 5% significantly decreased serum total cholesterol. Serum triglycerides and phospholipids were significantly decreased in both the fruit body and hot-water extract groups. Furthermore, Hatakeshimeji in the diet significantly increased the activity of cholesterol 7a-hydroxylase, which converts cellular cholesterol to bile acids, as well as the fecal excretion of bile acids.
authors.affiliation: Research Center Eishogen Co., Ltd., Fukaya, Saitama, Japan.
authors.forename: Yuuichi
authors.initials: Y
authors.lastname: Ukawa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Furuichi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kokean
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nishii
authors.forename: Makoto
authors.initials: M
authors.lastname: Hisamatsu
mesh_terms: D000363:Agaricales; D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D001835:Body Weight / Q000502:physiology; D002784:Cholesterol / Q000008:administration & dosage; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D004032:Diet; D005243:Feces; D005638:Fruit; D006937:Hypercholesterolemia / Q000517:prevention & control*; D008055:Lipids / Q000097:blood*; D008297:Male; D009929:Organ Size / Q000502:physiology; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001647:Bile Acids and Salts; D008055:Lipids; D010936:Plant Extracts; D002784:Cholesterol; D002790:Cholesterol 7-alpha-Hydroxylase