Promoter elements in the aflatoxin pathway polyketide synthase gene.
PksA catalyzes the formation of the polyketide backbone necessary for aflatoxin biosynthesis. Based on reporter assays and sequence comparisons of the nor1-pksA intergenic region in different aflatoxin-producing Aspergillus species, cis-acting elements for the aflatoxin pathway-specific regulatory protein, AflR, and the global-acting regulatory proteins BrlA and PacC are involved in pksA promoter activity.
Ehrlich
Kenneth C
KC
Southern Regional Research Center, United States Department of Agriculture, P.O. Box 19687, 1100 R.E. Lee Blvd., New Orleans, LA 70179, USA. erlich@nola.srrc.usda.gov
Montalbano
Beverly G
BG
Cary
Jeffrey W
JW
Cotty
Peter J
PJ
D000348:Aflatoxins / Q000096:biosynthesis*; D001230:Aspergillus / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000235:genetics* / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000378:metabolism
C113837:AFLR protein, Aspergillus; D000348:Aflatoxins; C063497:BRLA protein, Emericella nidulans; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D009097:Multienzyme Complexes; D009687:Nuclear Proteins; C092394:PacC protein, Aspergillus; D014157:Transcription Factors