title: Lumbar bone mineral density in normal subjects aged 3-6 years: a prospective study.
abstract: Longitudinal studies on bone mineral density (BMD) accrual in young children are scarce. The purpose of the present study was to evaluate prospectively the development of spinal BMD in healthy Finnish children aged 3-6 y by dual-energy x-ray absorptiometry (DXA). Lumbar spine (L2-L4) areal BMD (g/cm2) was measured by DXA (Lunar DPX) in 20 children (10M, 10F) aged 3.3-6.9 y (median 4.8 y) at baseline and after a median follow-up of 1.0y (range 0.8-1.1 y). Apparent volumetric BMD (BMDvol, g/cm3) was calculated to minimize the effect of bone size on BMD in growing spine. At baseline, lumbar areal and volumetric BMDs (mean +/- SD) for males were 0.623+/-0.087 g/cm2 and 0.270+/-0.034 g/cm3, respectively, and for females 0.620+/-0.082 g/cm2 and 0.254+/-0.035 g/cm3, respectively. During the median follow-up of 1 y, lumbar areal and volumetric BMDs (mean +/- SD) increased in males by 4.7+/-2.7% (p < 0.01) and 3.5+/-3.5% (p <0.05), respectively, and in females by 7.2+/-5.3% (p <0.01) and 3.1+/-3.1% (p <0.05), respectively. No statistically significant difference in the BMD values was observed between the sexes.
  
  
  CONCLUSIONS
  A significant increase in both areal and apparent volumetric BMD was observed in children aged 3-6 y during a follow-up of I y. The increase in volumetric BMD indicated that there was a real accrual of BMD in growing spine measured by DXA. The present study provides prospective data on BMD accrual in young children for the evaluation of bone mass development in early childhood.
authors.affiliation: Department of Pediatrics and Surgery, Kuopio University Hospital, Finland. pekka.arikoski@uku.fi
authors.forename: P
authors.initials: P
authors.lastname: Arikoski
authors.forename: J
authors.initials: J
authors.lastname: Komulainen
authors.forename: R
authors.initials: R
authors.lastname: Voutilainen
authors.forename: L
authors.initials: L
authors.lastname: Kröger
authors.forename: H
authors.initials: H
authors.lastname: Kröger
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000367:Age Factors; D001827:Body Height; D001835:Body Weight; D015519:Bone Density / Q000502:physiology*; D002648:Child; D002657:Child Development / Q000502:physiology; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008159:Lumbar Vertebrae; D008297:Male; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D012737:Sex Factors; D018709:Statistics, Nonparametric