title: Effectiveness of tramadol as an analgesic in oral surgery.
abstract: In a randomised, double-blind, cross-over trial, 15 healthy, young patients undergoing surgical removal of bilateral, impacted, third-molar teeth received the analgesic tramadol 50 mg, as a single dose, either 2 hours prior or immediately before the surgical procedure. There were no differences in the post-operative pain levels or degree of trismus between the two methods of administration of tramadol (P > 0.05), suggesting absence of any pre-emptive analgesic effect for the drug in the dose studied. The prevalence of unwanted side effects such as nausea (37 percent) was high within the first 24 hours.
authors.affiliation: Department of Stomatology, School of Dentistry, PO Box 647, Dunedin.
authors.forename: Rohana
authors.initials: R
authors.lastname: Kumara
authors.forename: Mathew
authors.initials: M
authors.lastname: Zacharias
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005157:Facial Pain / Q000517:prevention & control; D006801:Humans; D008964:Molar, Third / Q000601:surgery*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D020250:Postoperative Nausea and Vomiting / Q000209:etiology; D011300:Preoperative Care; D014081:Tooth Extraction; D014147:Tramadol / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol