Preparation, characterization, molecular modeling and in vitro activity of paclitaxel-cyclodextrin complexes.
Paclitaxel (PTX) was complexed with beta-cyclodextrin (1), 2,6-dimethyl-beta-cyclodextrin (2) and 2,3,6-trimethyl-beta-cyclodextrin (3). PTX-CYD complexes were characterized both at the solid and liquid states. Experimental findings are in agreement with molecular modeling analysis, which showed different PTX-CYD interaction as a function of macrocyle methylation. The complexation of PTX within the CYD cavity preserved its antitumoral activity.
Alcaro
Stefano
S
Department of Pharmacobiological Sciences, University Magna Graecia of Catanzaro, Complesso Ninì Barbieri, I-88021 Roccelletta di Borgia (CZ), Italy.
Ventura
Cinzia Anna
CA
Paolino
Donatella
D
Battaglia
Danilo
D
Ortuso
Francesco
F
Cattel
Luigi
L
Puglisi
Giovanni
G
Fresta
Massimo
M
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002942:Circular Dichroism; D003505:Cyclodextrins / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D003505:Cyclodextrins; D017239:Paclitaxel