title: Effects of recombinant activated factor VII on coagulation measured by thromboelastography in liver transplantation.
abstract: Besides the conventional laboratory tests, thromboelastography (TEG) is used to monitor hemostasis during liver transplantation. A previous pilot study suggested a beneficial effect of recombinant activated factor VII (rFVIIa) on transfusion requirements in liver transplantation. In the present study, we assess the effects of rFVIIa on coagulation variables and TEG. In six study patients, the prothrombin time (PT), the activated partial thromboplastin time (aPTT) and TEG variables [reaction time (r), kinetic time (k), or clot formation time, alpha angle (alpha), and maximal amplitude (MA)] were recorded before and after the administration of a bolus of 80 microg/kg rFVIIa. These patients were compared with six controls who did not receive rFVIIa. In contrast with the control group, a significant shortening of PT (P = 0.028) and aPTT (P = 0.028), r (P = 0.046) and k (P = 0.043) values, and a significant incline of the alpha angle (P = 0.028) were noticed after injection of rFVIIa, whereas MA increased not significantly (P = 0.075). rFVIIa rapidly improved coagulation variables in liver transplant patients including PT and aPTT. Of the TEG variables, r, k and alpha angle significantly improved, and MA showed a trend to increase. These data suggest that rFVIIa not only influences the speed of clot formation, but also the physical properties of the clot, which cannot be detected by routine coagulation tests.
authors.affiliation: Department of Anesthesiology, K. Meijer, University Hospital, Groningen, The Netherlands. h.g.d.hendriks@anest.azg.nl
authors.forename: H G D
authors.initials: HG
authors.lastname: Hendriks
authors.forename: K
authors.initials: K
authors.lastname: Meijer
authors.forename: J Th M
authors.initials: JT
authors.lastname: de Wolf
authors.forename: R J
authors.initials: RJ
authors.lastname: Porte
authors.forename: I J
authors.initials: IJ
authors.lastname: Klompmaker
authors.forename: H
authors.initials: H
authors.lastname: Lip
authors.forename: M J H
authors.initials: MJ
authors.lastname: Slooff
authors.forename: J
authors.initials: J
authors.lastname: van der Meer
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D016022:Case-Control Studies; D005167:Factor VII / Q000008:administration & dosage / Q000494:pharmacology*; D015942:Factor VIIa; D006801:Humans; D017093:Liver Failure / Q000097:blood; D016031:Liver Transplantation; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D013916:Thrombelastography
chemical_list: D011994:Recombinant Proteins; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa