Symptomatic and asymptomatic benign prostatic hyperplasia: molecular differentiation by using microarrays.
Benign prostatic hyperplasia (BPH) is a disease of unknown etiology that significantly affects the quality of life in aging men. Histologic BPH may present itself either as symptomatic or asymptomatic in nature. To elucidate the molecular differences underlying BPH, gene expression profiles from the prostate transition zone tissue have been analyzed by using microarrays. A set of 511 differentially expressed genes distinguished symptomatic and asymptomatic BPH. This genetic signature separates BPH from normal tissue but does not seem to change with age. These data could provide novel approaches for alleviating symptoms and hyperplasia in BPH.
Prakash
Kulkarni
K
Gene Logic Inc., 708 Quince Orchard Road, Gaithersburg, MD 20878, USA.
Pirozzi
Gregorio
G
Elashoff
Michael
M
Munger
William
W
Waga
Iwao
I
Dhir
Rajiv
R
Kakehi
Yoshiyuki
Y
Getzenberg
Robert H
RH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D000906:Antibodies; D003937:Diagnosis, Differential; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D020411:Oligonucleotide Array Sequence Analysis; D010446:Peptide Fragments / Q000276:immunology; D011467:Prostate / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology
D000906:Antibodies; D010446:Peptide Fragments