title: Attention deficit hyperactivity disorder and the gene for dopamine Beta-hydroxylase.
abstract: OBJECTIVE
  Attention deficit hyperactivity disorder (ADHD) has been shown to be highly heritable, and recent molecular genetics studies have focused on candidate genes in the dopaminergic and noradrenergic systems. One recent study reported an association of an allele of the TaqI polymorphism located in the fifth intron of the gene for dopamine beta-hydroxylase (DBH). The authors' goal was to replicate this finding.
  
  
  METHODS
  The authors investigated the linkage of the alleles and haplotypes of three polymorphisms at the DBH locus in 117 nuclear families with ADHD.
  
  
  RESULTS
  No significant evidence was found for linkage of the TaqI alleles or haplotypes in the 117 families. However, the authors observed some evidence for biased transmission of the same allele of the TaqI polymorphism, as previously reported.
  
  
  CONCLUSIONS
  These findings suggest that the gene for DBH should be investigated further.
authors.affiliation: Department of Psychiatry, Toronto Western Hospital, Ont., Canada.
authors.forename: Karen
authors.initials: K
authors.lastname: Wigg
authors.forename: Gwyneth
authors.initials: G
authors.lastname: Zai
authors.forename: Russell
authors.initials: R
authors.lastname: Schachar
authors.forename: Rosemary
authors.initials: R
authors.lastname: Tannock
authors.forename: Wendy
authors.initials: W
authors.lastname: Roberts
authors.forename: Molly
authors.initials: M
authors.lastname: Malone
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
authors.forename: Cathy L
authors.initials: CL
authors.lastname: Barr
mesh_terms: D000483:Alleles; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D002874:Chromosome Mapping; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005787:Gene Frequency; D008040:Genetic Linkage; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D009679:Nuclear Family; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D004299:Dopamine beta-Hydroxylase