title: Are Central Eastern European countries involved in clinical trials of supportive care?
abstract: Clinical trials are the most widely accepted tools in the search for more effective supportive care drugs/interventions. The aim of our study was to determine Central Eastern European countries' (CEEC) involvement and future interest in conducting supportive care clinical trials. Our study was a part of an ESMO/MASCC program launched to support the development of supportive care in CEEC. The study was designed as a mailed questionnaire survey within the ESMO CEE Task Force. It involves national representatives from 18 countries. The purpose of the questionnaire was to assess the involvement and interest in conducting clinical trials in 13 representative supportive care fields: antiemetic therapy, cancer pain control, infections/febrile neutropenia, mucositis, fatigue, hypercalcemia, dyspnea, anorexia/cachexia, psychosocial support, toxicity reducing agents, hematopoietic growth factors, communication/education and quality of life. A total of 15 completed questionnaires were returned (83.3%). CEEC were mainly involved in clinical trials of hematopoietic growth factors (7/15), quality of life (6/15), antiemetic therapy (5/15), and cancer pain control (4/15). Increased interest was observed in the trials of fatigue, dyspnea, psychosocial support, infections / febrile neutropenia, communication / education and toxicity reducing agents. Clusters of CEEC that are similar in terms of their previous involvement and future interest in supportive care trials were identified. Our survey may prove to be a significant first step for CEEC active involvement in multinational clinical trials, which are crucial for improving supportive care standards.
authors.affiliation: Institute for Oncology and Radiology of Serbia, Pasterova 14, 1000 Belgrade, FR Yugoslavia. bosnjaks@ncrc.ac.yu
authors.forename: Snezana
authors.initials: S
authors.lastname: Bosnjak
mesh_terms: D002986:Clinical Trials as Topic; D005061:Europe, Eastern; D019538:Health Care Surveys; D006801:Humans; D007391:International Cooperation; D009369:Neoplasms / Q000150:complications* / Q000628:therapy; D010166:Palliative Care; D011788:Quality of Life; D012107:Research Design