title: Multiple neoplasms: a case report.
abstract: Patients diagnosed with Chronic Lymphocytic Leukemia (CLL) have an increased risk of developing second primary cancers. However, as far as we know, more than one type of subsequent malignancy in one patient has not been described. We report a case of two different skin cancers following CLL. A 68-year-old female patient, in whom CLL was diagnosed 5 years earlier, presented with a pigmentation in the left lower eyelid. Biopsy showed a melanoma. The tumor was excised and histopathological examination revealed a superficial spreading melanoma. Half a year later, a new pigmented tumor was seen in the transplant of the left lower eyelid. Biopsy was performed and histopathological examination showed an intraepithelial squamous cell carcinoma. This was treated with 5 fluorouracil 1% eyedrops.
authors.affiliation: Department of Ophthalmology, VU-Medical Center, Amsterdam, The Netherlands.
authors.forename: M L E
authors.initials: ML
authors.lastname: Pigeaud-Klessens
authors.forename: P
authors.initials: P
authors.lastname: van der Valk
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D019882:Blepharoplasty; D002278:Carcinoma in Situ / Q000188:drug therapy / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology*; D005142:Eyelid Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D013524:Surgical Flaps
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil