title: Historical, psychopathological, neurological, and neuropsychological aspects of deficit schizophrenia: a multicenter study.
abstract: OBJECTIVE
  This multicenter study aimed to verify whether the historical and psychopathological characteristics of a large group of patients with deficit schizophrenia were consistent with those reported in previous studies. The authors also tested the hypothesis that neurological and neuropsychological indices sensitive to frontoparietal dysfunction, but not those sensitive to temporal lobe dysfunction, are more impaired in patients with deficit schizophrenia than in those with non-deficit schizophrenia.
  
  
  METHODS
  For each patient with deficit schizophrenia enrolled in the study, a matched subject with non-deficit schizophrenia was recruited. Historical, psychopathological, neurological, and neuropsychological evaluations were carried out for all patients.
  
  
  RESULTS
  Patients with deficit schizophrenia, compared with patients with non-deficit schizophrenia, had a similar severity of positive symptoms and disorganization and less hostility. They had poorer premorbid adjustment during childhood and early adolescence and exhibited more impairment in general cognitive abilities. The deficit state was associated with impairment in sequencing of complex motor acts, which suggests frontoparietal dysfunction.
  
  
  CONCLUSIONS
  Previous reports of differences in historical, psychopathological, and neuropsychological characteristics between patients with deficit schizophrenia and those with non-deficit schizophrenia were mostly supported by the present findings. Neurological findings suggest that frontoparietal functioning is more impaired in patients with deficit schizophrenia. Deficit schizophrenia might represent a neurodevelopmental subtype of schizophrenia in which significant behavioral and cognitive impairment since childhood compromises the development of basic capacities relevant to subsequent cognitive and social functioning.
authors.affiliation: University of Naples Department of Psychiatry, Italy. sgalderi@tin.it
authors.forename: Silvana
authors.initials: S
authors.lastname: Galderisi
authors.forename: Mario
authors.initials: M
authors.lastname: Maj
authors.forename: Armida
authors.initials: A
authors.lastname: Mucci
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Cassano
authors.forename: Giordano
authors.initials: G
authors.lastname: Invernizzi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Rossi
authors.forename: Antonio
authors.initials: A
authors.lastname: Vita
authors.forename: Liliana
authors.initials: L
authors.lastname: Dell'Osso
authors.forename: Enrico
authors.initials: E
authors.lastname: Daneluzzo
authors.forename: Stefano
authors.initials: S
authors.lastname: Pini
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000503:physiopathology; D012044:Regression Analysis; D012559:Schizophrenia / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000503:physiopathology