Effects of carprofen on renal function and results of serum biochemical and hematologic analyses in anesthetized dogs that had low blood pressure during anesthesia.
OBJECTIVE
To investigate effects of IV administered carprofen on indices of renal function and results of serum biochemical and hematologic analyses in dogs anesthetized with acepromazine-thiopentone-isoflurane that had low blood pressure during anesthesia.


METHODS
6 healthy Beagles.


METHODS
A randomized crossover study was conducted, using the following treatments: saline (0.9% NaCl solution)-saline, saline-carprofen, and carprofen-saline. Saline (0.08 ml/kg) and carprofen (4 mg/kg) were administered IV. The first treatment was administered 30 minutes before induction of anesthesia and immediately before administration of acepromazine (0.1 mg/kg, IM). Anesthesia was induced with thiopentone (25 mg/ml, IV) and maintained with inspired isoflurane (2% in oxygen). The second treatment was administered 30 minutes after onset of inhalation anesthesia. Blood gases, circulation, and ventilation were monitored. Renal function was assessed by glomerular filtration rate (GFR), using scintigraphy, serum biochemical analyses, and urinalysis. Hematologic analysis was performed. Statistical analysis was conducted, using ANOVA or Friedman ANOVA.


RESULTS
Values did not differ significantly among the 3 treatments. For all treatments, sedation and anesthesia caused changes in results of serum biochemical and hematologic analyses, a decrease in mean arterial blood pressure to 65 mm Hg, an increase of 115 pmol/L in angiotensin II concentration, and an increase of 100 seconds in time required to reach maximum activity counts during scintigraphy.


CONCLUSIONS
Carprofen administered IV before or during anesthesia did not cause detectable significant adverse effects on renal function or results of serum biochemical and hematologic analyses in healthy Beagles with low blood pressure during anesthesia.
Boström
Ingrid M
IM
Department of Small Animals, National Veterinary Institute, Uppsala, Sweden.
Nyman
Görel C
GC
Lord
Peter E
PE
Häggström
Jens
J
Jones
Bernt E V
BE
Bohlin
Henrik P
HP
D000075:Acepromazine / Q000494:pharmacology; D000769:Anesthesia, Inhalation / Q000009:adverse effects / Q000662:veterinary*; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D001774:Blood Chemical Analysis / Q000662:veterinary; D002227:Carbazoles / Q000008:administration & dosage / Q000494:pharmacology*; D018592:Cross-Over Studies; D004285:Dogs / Q000378:metabolism / Q000502:physiology*; D018492:Dopamine Antagonists; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000662:veterinary*; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007022:Hypotension / Q000503:physiopathology*; D007530:Isoflurane / Q000494:pharmacology; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D011877:Radionuclide Imaging; D011897:Random Allocation; D013874:Thiopental / Q000494:pharmacology; D016482:Urinalysis / Q000662:veterinary; D014667:Vasopressins / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D018492:Dopamine Antagonists; D006993:Hypnotics and Sedatives; D014667:Vasopressins; D000804:Angiotensin II; D000075:Acepromazine; D007530:Isoflurane; C007005:carprofen; D013874:Thiopental