[Superantigens of Group A Streptococcus].
In this review the superantigens (SAG) of group A Streptococcus, mainly pyrogenic toxins, and the coding genes are characterized. Specific sites on the molecules of the main histocompatibility complex, class II, and T-receptors, interacting with SAG, are described. This interaction results in hyperproduction of cytokines posing a systemic influence and leading to severe consequences. The data on the state of protective immunity in SAG-associated diseases and some approaches to their treatment are given.
Danilova
T A
TA
Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
D000942:Antigens, Bacterial / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis; D005098:Exotoxins / Q000276:immunology; D005802:Genes, MHC Class II / Q000276:immunology; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D013297:Streptococcus pyogenes / Q000276:immunology*; D018089:Superantigens / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000942:Antigens, Bacterial; D016207:Cytokines; D005098:Exotoxins; D011948:Receptors, Antigen, T-Cell; D018089:Superantigens