Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B.
The synthesis and acetylcholinesterase inhibition activity of analogues of huperzine B are reported. These new racemic analogues show a better AChE inhibitory activity than the natural product huperzine B.
Rajendran
V
V
Drug Discovery Program, Department of Neurology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington DC 20007-2197, USA.
Saxena
Ashima
A
Doctor
Bhupendra P
BP
Kozikowski
Alan P
AP
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D009946:Organothiophosphorus Compounds / Q000737:chemistry; D013329:Structure-Activity Relationship
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds; C053016:huperzine B; C029887:2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide