title: Continuous synthesis of amorphous carbonated apatites.
abstract: Amorphous carbonated hydroxyapatite was prepared by rapid mixing of aqueous solutions of a continuous computer-controlled reactor. The variation of the carbonate content in the solid product is possible by adjustment of the ratios of phosphate to carbonate in the initial solution. The principal reaction parameters (temperature, pH, stirrer speed, solution composition and supersaturation) are controlled and monitored. By controlling these processing parameters, a non-stoichiometric hydroxyapatite with fine-tuned crystallinity, morphology, and carbonate content can be reproducibly prepared. The higher solubility under the conditions of osteoclastic resorption was tested in vitro at constant pH (4.4).
authors.affiliation: Solid State Chemistry, Faculty of Chemistry, University of Bochum, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Tadic
authors.forename: F
authors.initials: F
authors.lastname: Peters
authors.forename: M
authors.initials: M
authors.lastname: Epple
mesh_terms: D001031:Apatites / Q000138:chemical synthesis* / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry; D002254:Carbonates / Q000138:chemical synthesis* / Q000737:chemistry; D003460:Crystallization / Q000295:instrumentation / Q000379:methods; D006863:Hydrogen-Ion Concentration; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002254:Carbonates