title: [Breast angiosarcoma in a patient with multiple surgical procedures and breast implant. Report of a case].
abstract: We report the case of a 39 years old woman, with bilateral fibrocystic breast disease and several surgeries for this cause, including bilateral mammary implants. Nineteen months after the implants an angiosarcoma of the left breast was diagnosed. In the specimen from radical mastectomy infiltration of the adipose tissue was found but no metastases to the axillary lymph node resected. Prognostic factors were investigated in surgical specimen and immunophenotypic characterization was made, considering Ki-67 and p53 expression. The patient finished chemotherapic treatment and is well, without neoplastic disease relapse, 16 months after diagnosis. We comment the possible relation between silicona's implants and angiosarcoma's genesis, association not reported before in the literature. The adverse effects of silicone implants and angiosarcoma histogenesis were reviewed.
authors.affiliation: Servicio, de Patologia Quirúrgica, Hospital ABC, México D.F.
authors.forename: Teresa
authors.initials: T
authors.lastname: Cuesta-Mejías
authors.forename: Beatriz
authors.initials: B
authors.lastname: de León-Bojorge
authors.forename: José
authors.initials: J
authors.lastname: Abel de la Peña
authors.forename: Jorge
authors.initials: J
authors.lastname: Valenzuela-Tamariz
mesh_terms: D000328:Adult; D018427:Breast Implants / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000209:etiology* / Q000473:pathology; D005260:Female; D006394:Hemangiosarcoma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology*