title: Ectopic ACTH-syndrome due to a thymic carcinoid tumor.
abstract: Investigating a recently developed Cushing Syndrome, we diagnosed in a 47-year-old woman an ectopic ACTH syndrome due to a metastatic carcinoid tumor, most likely a thymic carcinoid tumor. Combined therapy with sandostatin and nizoral and later on with sandostatin, metopirone and orimeten, was not able to suppress the hypercortisolism. A few weeks after surgical adrenalectomy, clinical deterioration ensued, culminating in the patient's death 7 months after diagnosis.
authors.affiliation: Department of Endocrinology, AZ Sint Jan, Ruddershove 10, 8000 Bruges. Sandra.Vanschaeybroeck@uz.kuleuven.ac.be
authors.forename: S
authors.initials: S
authors.lastname: Van Schaeybroeck
authors.forename: S
authors.initials: S
authors.lastname: Van Imschoot
authors.forename: P
authors.initials: P
authors.lastname: Cochez
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000188:drug therapy / Q000209:etiology*; D000616:Aminoglutethimide / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000963:Antimetabolites / Q000627:therapeutic use; D002276:Carcinoid Tumor / Q000188:drug therapy / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D008797:Metyrapone / Q000627:therapeutic use; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use; D013953:Thymus Neoplasms / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D000963:Antimetabolites; D004791:Enzyme Inhibitors; D006728:Hormones; D000616:Aminoglutethimide; D007654:Ketoconazole; D015282:Octreotide; D008797:Metyrapone