Database of bronchoalveolar lavage fluid proteins.
Bronchoalveolar lavage during fiberoptic bronchoscopy is extensively used for investigating cellular and biochemical alterations of the epithelial lining fluid in various lung disorders. Two-dimensional electrophoresis (2-DE) offers the possibility to simultaneously display and analyze proteins contained in bronchoalveolar lavage fluid (BALF). We present the current status of 2-DE of BALF samples with an updated listing of the proteins already identified and of their level and/or posttranslational alterations in lung disorders. Alternatives to 2-DE of BALF samples and future prospects of proteomics to unravel lung functions and pathologies are discussed.
Noël-Georis
Isabelle
I
Department of Biological Chemistry, University of Mons-Hainaut, Avenue du Champs de Mars 6, B-7000 Mons, Belgium. isabelle.georis@umh.ac.be
Bernard
Alfred
A
Falmagne
Paul
P
Wattiez
Ruddy
R
D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D030562:Databases, Protein; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D011506:Proteins / Q000737:chemistry*
D011506:Proteins