Lewy body-free nigral degeneration--a case report.
A 70-year-old Japanese woman developed progressive, dopa-responsive parkinsonism consisting of akinesia, resting tremor, rigidity, and postural instability. Neuropathological examination revealed a marked loss of nigral neurons, but no Lewy bodies (LBs) were observed. Lewy bodies were also absent from their usual site, with the exception of a small number seen in the dorsal motor nucleus of the vagus nerve (DVN) and sympathetic ganglion. We propose that our case and several similar reported cases represent Lewy body-free nigral degeneration.
Ishihara
Kenji
K
Department of Neurology, Showa University School of Medicine, Shinagawa, Tokyo, Japan. kishi@med.showa-u.ac.jp
Nonaka
Akiko
A
Fukui
Toshiya
T
Kawamura
Mitsuru
M
Shiota
Jun-ichi
J
Nakano
Imaharu
I
D000368:Aged; D004295:Dihydroxyphenylalanine / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology*; D009410:Nerve Degeneration / Q000473:pathology*; D020734:Parkinsonian Disorders / Q000188:drug therapy / Q000473:pathology*; D013378:Substantia Nigra / Q000473:pathology*
D004295:Dihydroxyphenylalanine