Inhibition of Na,K-dependent adenosine triphosphatase by adenosine in intact pigeon erythrocytes.
In intact pigeon erythrocytes, adenosine is a potent inhibitor of Na,K-dependent adenosine triphosphatase. In purified cell-membrane preparations, adenosine is only a weak competitive inhibitor of Na,K-ATPase, with respect to ATP. This indicates that adenosine must not be a direct inhibitor of the sodium pump in intact red cells per se; instead, adenosine exerts its inhibitory effect via endogenous cell factors.
Leskovac
V
V
Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Novi Sad, Yugoslavia.
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D010856:Columbidae; D004176:Dipyridamole / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D066298:In Vitro Techniques; D007700:Kinetics; D011188:Potassium / Q000032:analysis; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects / Q000378:metabolism*; D013805:Theobromine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology
D014970:Xanthines; C032114:propentofylline; D004176:Dipyridamole; D000254:Sodium-Potassium-Exchanging ATPase; D000241:Adenosine; C007942:pentifylline; D013805:Theobromine; D011188:Potassium