[New guideline for the management of hyperlipidemia according to patient category and global risk chart].
Risk charts for predicting coronary heart disease(CHD) based on the Framingham Study are not valid for other ethnic people including Japanese, and no large scale prospective study exists which has examined the relationship between coronary risk factors and the incidence of CHD in Japan. The Japan Lipid Intervention Trial(J-LIT) is a 6-year prospective study of simvastatin therapy for mild hypercholesterolemia in a clinical setting. Major coronary events were observed in 336 patients in the primary prevention cohort(47,294) and 102 patients in the secondary prevention cohort(5,127) during the study period. Consequently we were able to create easy-to-use charts that predict the absolute risk of developing a coronary event based on determinable risk factors. Absolute risks were lower than predicted by the Framingham formula. The J-LIT charts demonstrate absolute and relative risks for primary and secondary coronary events in Japanese patients. Their use should help individualize risk factor management.
Mabuchi
Hiroshi
H
Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University.
D003327:Coronary Disease / Q000517:prevention & control*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012307:Risk Factors