Adenovirus-5 E1A: paradox and paradigm.
The adenovirus early region 1A (E1A) proteins were described originally as immortalizing oncoproteins that altered transcription in rodent cells. Surprisingly, the 243-amino-acid form of adenovirus-5 E1A was found subsequently to reverse-transform many human tumour cells. Tumour suppression apparently results from the ability of E1A to re-programme transcription in tumour cells, and the molecular basis of this intriguing effect is now beginning to emerge. These discoveries have provided a tool with which to study the regulation of fundamental cellular processes.
Frisch
Steven M
SM
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA. sfrisch@burnham-inst.org
Mymryk
Joe S
JS
D017500:Adenovirus E1A Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D000260:Adenoviruses, Human / Q000235:genetics / Q000378:metabolism; D000595:Amino Acid Sequence; D016147:Genes, Tumor Suppressor; D006801:Humans; D008969:Molecular Sequence Data; D009857:Oncogenes; D016160:Retinoblastoma Protein / Q000378:metabolism
D017500:Adenovirus E1A Proteins; D016160:Retinoblastoma Protein