title: Progesterone receptor immunoreactivity in minute meningothelioid nodules of the lung.
abstract: Meningothelioid nodules (MNs) are not uncommon lesions of the pulmonary interstitium composed of monomorphic round to spindle cells, likely reactive in nature. Their origin is unsettled, though a derivation from arachnoid-like cells in conditions of perturbed perfusion of the pulmonary tissue has been proposed. Here we confirm the consistent occurrence of intense progesterone-receptor immunoreactivity in MNs fortuitously detected in surgical specimens of lung carcinomas. This finding corroborates the view that these proliferations exhibit arachnoid cell-like differentiation and suggests a role for sex-steroid hormones in the control of their growth.
authors.affiliation: Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Via G. Ripamonti 435, 20141 Milan, Italy. giuseppe.pelosi@ieo.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pelosi
authors.forename: Fausto
authors.initials: F
authors.lastname: Maffini
authors.forename: Nicola
authors.initials: N
authors.lastname: Decarli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Viale
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D010236:Paraganglioma, Extra-Adrenal / Q000737:chemistry* / Q000473:pathology; D011980:Receptors, Progesterone / Q000032:analysis*; D014746:Vimentin / Q000032:analysis
chemical_list: D018396:Mucin-1; D011980:Receptors, Progesterone; D014746:Vimentin