title: Long-term follow-up of concurrent radiotherapy and chemotherapy for locally advanced cervical cancer: 12-Year survival after radiochemotherapy.
abstract: Recently randomized trials show an overall survival advantage of 30% for cisplatin-based chemotherapy given concurrently with radiation therapy. Current data do not allow to conclude which drugs could be best combined with cisplatin. Here we report the very long-term results of a prospective phase II trial of concurrent radiochemotherapy in advanced cancer of the cervix. Psychological impact has been evaluated with long-term survivors. Patient with squamous cell carcinoma of the cervix FIGO stage IIB, III or IVA received a concomitant chemotherapy with cisplatin, fluorouracil and mitomycin C and radiotherapy. From June 1988 to September 1990, 22 of 23 patients were eligible. The overall response rate was 82%. All 22 patients treated showed acute hematological toxicity and two patients developed severe late bowel toxicity. Ten patients (45%) were alive after a median observation time of 145.5 months. Intolerance to certain food and vaginal changes due to radiotherapy remain problematic. The lack of improvement compared to cisplatin alone and late bowel toxicity do not support the use of mitomycin C in the combination of the concurrent treatment of chemoradiation. The psychological impact of this treatment should not be minimized. Most problems tend to diminish with time with the exception of intestinal side effects and vaginal changes.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital, Inselspital Bern, Schanzeneckstrasse 1, 3012, Switzerland. gilles.berclaz@insel.ch
authors.forename: Gilles
authors.initials: G
authors.lastname: Berclaz
authors.forename: Eva
authors.initials: E
authors.lastname: Gerber
authors.forename: Karl
authors.initials: K
authors.lastname: Beer
authors.forename: Stefan
authors.initials: S
authors.lastname: Aebi
authors.forename: Richard
authors.initials: R
authors.lastname: Greiner
authors.forename: Ekkehard
authors.initials: E
authors.lastname: Dreher
authors.forename: Katharina
authors.initials: K
authors.lastname: Buser
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D016685:Mitomycin / Q000008:administration & dosage; D010349:Patient Compliance; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D017211:Treatment Failure; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000523:psychology / Q000628:therapy*
chemical_list: D016685:Mitomycin; D002945:Cisplatin; D005472:Fluorouracil