18F-FDG and 11C-methionine PET in choroid plexus papilloma--report of three cases.
Choroid plexus papilloma (CCP) is an uncommon benign neoplasm of the neuroectoderm. We present the 18F-fluoro-2-deoxy-D-glucose (FDG) and 11C-methyl-L-methionine (methionine) positron emission tomography of CPP in comparison with that of low-grade glioma. Patients were two women and one man (20, 23, and 72 years old). The Ki-67 labeling index ranged from 0.98 to 2.22%, and histologically the cases belonged to grade 2. On quantitative analysis, the tumor/normal ratio (T/N) was calculated using the standardized uptake value. Methionine T/N was significantly higher in CPP (3.24+/-0.69) than in low-grade glioma (1.23+/-0.81; p<0.01), although no clear difference could be determined for FDG T/N between the two (0.87+/-0.39, 0.75+/-0.53). These results may suggest that the metabolism of amino acid in CPP is quite different from that in low-grade glioma.
Sunada
Ichiro
I
Department of Neurosurgery, Saiseikai Ibaraki Hospital, Mitsukeyama, Japan
Tsuyuguchi
Naohiro
N
Hara
Mitsuhiro
M
Ochi
Hironobu
H
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging; D002250:Carbon Radioisotopes; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008715:Methionine; D020288:Papilloma, Choroid Plexus / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D008715:Methionine