title: Hericenols A-D and a chromanone from submerged cultures of a Stereum species.
abstract: Extracts of submerged cultures of a Stereum species afforded four new pentasubstituted phenolic compounds, named hericenols A, B, C, and D (1-4), 6-hydroxymethyl-2,2-dimethylchroman-4-one (5) and the known erinapyrone C. Hericenol A (1) showed weak antimicrobial activity while hericenol C (3) was weakly cytotoxic. The structures of the metabolites were determined by spectroscopic techniques.
authors.affiliation: LB Biotechnology, University of Kaiserslautern, Paul-Ehrlich-Str. 23, D-67663 Kaiserslautern, Germany.
authors.forename: Josiah Ouma
authors.initials: JO
authors.lastname: Omolo
authors.forename: Heidrun
authors.initials: H
authors.lastname: Anke
authors.forename: Olov
authors.initials: O
authors.lastname: Sterner
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000737:chemistry* / Q000187:drug effects / Q000302:isolation & purification; D019556:COS Cells; D002845:Chromatography / Q000379:methods; D002867:Chromones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D003106:Colon / Q000166:cytology / Q000187:drug effects; D007630:Kenya; D007939:Leukemia L1210; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002867:Chromones; D010636:Phenols