Direct L-proline-catalyzed asymmetric alpha-amination of ketones.
The first direct catalytic asymmetric alpha-amination of ketones catalyzed by l-proline has been developed. The reactions proceed with various azodicarboxylates as the nitrogen source in high yields and excellent enantioselectivities (up to 99% ee). The scope and potential of the reaction are demonstrated by further transformation of the alpha-hydrazino ketones formed to both optically active syn and anti-alpha-amino alcohol derivatives.
Kumaragurubaran
Nagaswamy
N
Center for Catalysis, Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark.
Juhl
Karsten
K
Zhuang
Wei
W
Bøgevig
Anders
A
Jørgensen
Karl Anker
KA