Monocyte/macrophage initiation of organ-specific autoimmunity: the ultimate 'bystander' hypothesis?
It is postulated that organ-specific autoimmune diseases could be initiated by dysregulated peripherally activated monocytes/macrophages penetrating into target organs nonspecifically. Failure of regulation of pro-inflammatory monocytes/macrophages might then result in autoimmune disease if secondary over-expansion of pre-existing autoantigen-specific T cell populations occurs in genetically predisposed individuals.
Stoy
N S
NS
Royal Hospital for Neuro-disability, West Hill, Putney, London, UK.
D000818:Animals; D017951:Antigen Presentation; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000473:pathology; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D015551:Autoimmunity / Q000502:physiology*; D002448:Cell Adhesion; D002465:Cell Movement; D016207:Cytokines / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000473:pathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology; D004730:Endothelium, Vascular / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007239:Infections / Q000150:complications / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D008262:Macrophage Activation; D008264:Macrophages / Q000473:pathology*; D051379:Mice; D016688:Mice, Inbred NOD; D023421:Models, Animal; D018448:Models, Immunological; D009000:Monocytes / Q000473:pathology*; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology; D009928:Organ Specificity; D051381:Rats; D011922:Rats, Mutant Strains
D016207:Cytokines