Tumor regression of B16F10 melanoma in vivo by prevention of neovascularization: study on theophylline.
The aim of this study was to determine the effect of theophylline on neovascularization and tumor regression in murine B16F10 melanoma. Theophylline had no direct toxicity to host and significantly reduced (p < 0.001) tumor volume and neovascularization in B16F10 melanoma implanted murine model. The effect of theophylline on neovascularization was observed distinctly in histologic analysis. This effect is mediated, in part by blocking endothelial cell proliferation, thereby preventing neovascularization of the tumor. Further investigations with theophylline can elucidate the exact mechanism of action which characterize neovascularization activity.
Menon
Lata G
LG
Chemotherapy Division, Cancer Research Institute, Parel, Mumbai-400 012, India. cri3@soochak.ncst.ernet.in
Ingle
A D
AD
Gude
R P
RP
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D005260:Female; D008546:Melanoma, Experimental / Q000098:blood supply* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic / Q000473:pathology / Q000517:prevention & control*; D013806:Theophylline / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D013806:Theophylline