In vitro susceptibility of four serotypes of enterohaemorrhagic Escherichia coli to antimicrobial agents.
We evaluated the in vitro susceptibility of four serotypes of enterohaemorrhagic Escherichia coli (E. coli 026, E. coli O111, E. coli O157, and E. coli O165) with diverse DNA patterns to antimicrobial agents. The minimum inhibitory concentrations (MIC) determined in a total of 83 strains using Mueller-Hinton agar under aerobic and anaerobic conditions were 0.015-0.12 microg/ml for ciprofloxacin, 0.06-1 microg/ml for norfloxacin, 2-64 microg/ml for fosfomycin without glucose-6-phosphate (G-6-P), 0.25-32 microg/ml for fosfomycin with G-6-P, 2- > or = 256 microg/ml for kanamycin, 0.125-2 microg/ml for cefoperazone, and 0.06-1 microg/ml for ceftazidime. The MIC of ciprofloxacin, norfloxacin, cefoperazone, and ceftazidime were low in all strains examined.
Oie
Shigeharu
S
Department of Pharmacy, Yamaguchi University Hospital, Ube, Japan.
Kawakami
Masatada
M
Kamiya
Akira
A
Tomita
Masaaki
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004927:Escherichia coli Infections / Q000382:microbiology; D019453:Escherichia coli O157 / Q000187:drug effects* / Q000378:metabolism; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents