title: [Study on cytotoxicity to leukemia cell and enhancement of immunologic functions of jiexinkang].
abstract: Cytotoxicity to leukemia cell and enhancement of immunologic functions of jiexinkang (JXK, traditional Chinese medicine) were observed in 34 cases of leukemia in vitro. The results showed that the leukemia cytotoxicity in the group of vincristine combined with JXK was significantly higher than that in vincristine alone. It was also found among all the observed cases that 20 refractory or recurred patients resistant to vincristine showed an obvious intention of the anti-toxicity efficiency when JXK was added. Jiexinkang alone had anti-leukemia cell effect, too. We explored JXK effects on immunologic functions in mice, and found that IFNr and NK activities of normal and experimental model mice were significantly higher than those of control group(P < 0.01). The results indicate that JXK has an effect of anti-leukemia cell and may improve the cell-immunologic functions.
authors.affiliation: Department of Hematology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
authors.forename: Z
authors.initials: Z
authors.lastname: Xie
authors.forename: D
authors.initials: D
authors.lastname: Tan
authors.forename: J
authors.initials: J
authors.lastname: Xie
authors.forename: Q
authors.initials: Q
authors.lastname: Qin
authors.forename: G
authors.initials: G
authors.lastname: Tan
authors.forename: P
authors.initials: P
authors.lastname: Xu
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000473:pathology; D003602:Cytotoxicity, Immunologic; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008297:Male; D051379:Mice; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014750:Vincristine