99mTc-N, N'-bis(aminoethyl)propanediamine hexaacetic acid (BPHA): a glomerular filtration agent similar to 99mTc-DTPA.
Investigations on the biodistribution of 99mTc-BPHA in normal and probenecid treated mice and a comparison with 99mTc-DTPA injected mice suggested that 99mTc-BPHA is also a glomerular filtration agent. Whole body radioactivity measurements in mice and rabbits after administration of 99mTc-BPHA showed negligible whole body radioactivity at 24 h. Excellent kidney images both in rabbits and a human volunteer were obtained. The significance of higher GFR estimates using 99mTc-BPHA compared to 99mTc-DTPA is discussed.
Liu
Guozheng
G
Isotope Department, China Institute of Atomic Energy, Beijing, Peoples Republic of China. Guozheng.Liu@umassmed.edu
Zhang
Chunli
C
Liu
Fei
F
Wang
Rongfu
R
Fu
Zhanli
Z
Li
Guiqun
G
Miao
Zengxing
Z
D000085:Acetates / Q000493:pharmacokinetics; D000818:Animals; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D011073:Polyamines / Q000493:pharmacokinetics; D011339:Probenecid / Q000008:administration & dosage; D011817:Rabbits; D011866:Radioisotope Renography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012016:Reference Values; D012680:Sensitivity and Specificity; D017556:Technetium Compounds; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014915:Whole-Body Counting
D000085:Acetates; D009942:Organometallic Compounds; D011073:Polyamines; D019275:Radiopharmaceuticals; D017556:Technetium Compounds; C469342:technetium Tc 99m N,N'-bis(aminoethyl)propanediaminehexaacetic acid; C064279:N,N-bis(2-aminoethyl)-1,3-propanediamine; D011339:Probenecid; D016284:Technetium Tc 99m Pentetate