HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides) in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial.
The aim of this study was to demonstrate whether HR (Paroven-Venoruton; 0-(beta-hydroxyethyl)-rutosides), was effective in improving the microcirculation in venous hypertension and microangiopathy. Sixty patients with severe venous hypertension due to chronic venous insufficiency, ankle swelling, and lipodermatosclerosis were included. After informed consent, patients were randomized into a treatment group and a placebo group. Patients in the treatment group received oral HR (2 g/day for 8 weeks); those in the placebo group received a comparable placebo.


RESULTS
The two groups were comparable for age and sex distribution. The mean age was 45 years (SD 9) in the treatment group (31 patients) and 45.5 (SD 10) in the placebo group (29 patients). There were no differences between the placebo and treatment groups at inclusion. There was no change between inclusion and measurements at 8 weeks in the placebo group. A significant decrease (P < 0.05) in flux at rest and rate of ankle swelling was observed in the treatment group. The decrease in capillary filtration was associated with improvement in signs and symptoms (P < 0.05). The difference in flux, sign and symptoms, and filtration was clinically important at 8 weeks in the treatment group when compared with the placebo group. No adverse effects were observed.


CONCLUSIONS
Venous microangiopathy was improved by HR treatment.
Incandela
L
L
Irvine2 Vasc Lab and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy.
Belcaro
G
G
Renton
S
S
DeSanctis
M T
MT
Cesarone
M R
MR
Bavera
P
P
Ippolito
E
E
Bucci
M
M
Griffin
M
M
Geroulakos
G
G
Dugall
M
M
Golden
G
G
Acerbi
G
G
D000328:Adult; D004487:Edema; D005260:Female; D006801:Humans; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006973:Hypertension / Q000150:complications*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D010919:Placebos; D011446:Prospective Studies; D012883:Skin Ulcer; D016896:Treatment Outcome; D014652:Vascular Diseases / Q000188:drug therapy*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014689:Venous Insufficiency / Q000188:drug therapy / Q000209:etiology
D006896:Hydroxyethylrutoside; D010919:Placebos; D014662:Vasoconstrictor Agents; C005865:troxerutin