title: Effects of acid-base abnormalities on blood capacity of transporting CO(2): adverse effect of metabolic acidosis.
abstract: OBJECTIVE
  To investigate the effects of some acid-base abnormalities on blood capacity of transporting CO(2).
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  General and Cardiosurgical ICUs of a University hospital.
  
  
  METHODS
  Six groups of ten patients characterized by: metabolic alkalosis; respiratory alkalosis; absence of acid-base abnormalities; metabolic acidosis; uncompensated respiratory acidosis; and compensated respiratory acidosis.
  
  
  RESULTS
  The CO(2) dissociation curve, Haldane effect, and the ratio Ra-v between Ca-vCO(2) and Pa-vCO(2) were calculated from arterial and mixed-venous blood gas analyses. The CO(2) dissociation curve was shifted upwards by metabolic alkalosis and compensated respiratory acidosis and downwards by metabolic acidosis. The slope of the curve was unaffected, but CO(2) transport not due to Haldane effect was significantly lower in respiratory acidosis since the slope was less steep at higher PCO(2) values. In comparison with controls, patients affected by metabolic acidosis showed lower Haldane effect values (0.18+/-0.15 vs 0.59+/-0.26 ml of CO(2) per ml of arterial-mixed venous O(2) content difference; P <.05) and Ra-v values (0.43+/-0.10 vs 0.84+/-0.17 ml of CO(2) transported by 100 ml of blood per Torr of arterial-mixed venous PCO(2) gradient; P <.05).
  
  
  CONCLUSIONS
  Our findings suggest that acid-base abnormalities, particularly metabolic acidosis, markedly affect blood capacity of transporting CO(2) and may worsen tissue hypercarbia associated with hypoperfusion. However, because of possible errors due to small measurements and the assumptions of the method, in the future definitive clarification will require the construction of original CO(2) dissociation curves for each acid-base abnormality.
authors.affiliation: Institute of Anaesthesia and Intensive Care, Catholic University of the Sacred Heart, Largo Francesco Vito, 1, 00168 Rome, Italy. f.cavaliere@rm.unicatt.it
authors.forename: F
authors.initials: F
authors.lastname: Cavaliere
authors.forename: M
authors.initials: M
authors.lastname: Antonelli
authors.forename: A
authors.initials: A
authors.lastname: Arcangeli
authors.forename: G
authors.initials: G
authors.lastname: Conti
authors.forename: M A
authors.initials: MA
authors.lastname: Pennisi
authors.forename: R
authors.initials: R
authors.lastname: Proietti
mesh_terms: D000138:Acidosis / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000471:Alkalosis / Q000378:metabolism*; D000704:Analysis of Variance; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D002245:Carbon Dioxide