Vaccination of C57BL/10 mice against cutaneous Leishmaniasis using killed promastigotes of different strains and species of Leishmania.
Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin(R) and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection.
Mayrink
Wilson
W
Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG.
Santos
Gilmara Cristina dos
GC
Toledo
Vicente de Paulo Coelho Peixoto de
Vde P
Guimaraes
Tânia Mara Pinto Dabés
TM
Machado-Coelho
George Luis Lins
GL
Genaro
Odair
O
da Costa
Carlos Alberto
CA
D000818:Animals; D005260:Female; D007891:Leishmania / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000517:prevention & control / Q000662:veterinary*; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology*; D016052:Protozoan Vaccines / Q000627:therapeutic use*; D014611:Vaccination
D016052:Protozoan Vaccines