title: [Age-dependency of isotope drainage in diuretic renograms].
abstract: OBJECTIVE
  The aim of the study was to establish normal values of the isotope drainage in diuretic scintigrams for children of different age-groups. Isotope drainage was determined 30 minutes after the application of technetium- (99m)MAG 3 as well as 15 minutes after the following application of furosemide.
  
  
  METHODS
  We analysed the data from 274 investigations in sonographically normal renal units (RU) contralateral to kidneys with ureteropelvic junction obstruction or non-refluxing primary megaureters.
  
  
  RESULTS
  There was a significant age-dependency of isotope drainage during the first weeks of life. In 79 RU the results of the first diuretic renogramm were compared with the follow-up examinations. The reliability of the measurements was lowest in children initially investigated during the first six weeks of life. If both the investigations were performed thereafter, no significant difference was found between the results.
  
  
  CONCLUSIONS
  The isotope drainage of the sonographically normal contralateral RU seems to be a sufficient marker for the meaningfulness of the diuretic renogram. In urinary tract dilatation, mistakes regarding the interpretation of isotope drainage may be minimized by taking the measurements in the normal contralateral RU in account and by comparing them with age-referred normal values.
authors.affiliation: Universitätskinderklinik, Mainz, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Beetz
authors.forename: P
authors.initials: P
authors.lastname: Bartenstein
authors.forename: R
authors.initials: R
authors.lastname: Stein
mesh_terms: D002648:Child; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D004231:Diuresis / Q000502:physiology*; D005260:Female; D005665:Furosemide; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011866:Radioisotope Renography; D012016:Reference Values; D015203:Reproducibility of Results; D017263:Technetium Tc 99m Mertiatide; D014517:Ureteral Obstruction / Q000503:physiopathology; D014563:Urodynamics / Q000502:physiology
chemical_list: D017263:Technetium Tc 99m Mertiatide; D005665:Furosemide