Hypertonic saline solution resuscitation in hemorrhagic shock dogs.
OBJECTIVE
To find out the optimal concentration, infusion rate and dosage of saline for resuscitation.


METHODS
Forty-five dogs were used to establish hypovolemic shock models. The dogs were resuscitated with saline of different concentrations and different dosages under different infusion rates, and the resuscitation results were compared.


RESULTS
The best concentration was 7.5%, the best rate of infusion 20 ml/min (a volume equivalent to 15% of the shed blood) and the best dosage 5.71 ml/kg. The method was effective for resuscitation, the mean arterial pressure (MAP) could be elevated to 89% of the baseline, and this MAP could be kept for more than one hour.


CONCLUSIONS
Using 7.5% sodium chloride solution equivalent to 15% of the shed blood at an infusion rate of 20 ml/min can achieve a best resuscitation result.
Cai
Xiujun
X
Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China. cxjzu@hotmail.com
Huang
Diyu
D
Mu
Yiping
Y
Peng
Shuyou
S
D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D001835:Body Weight; D004285:Dogs; D004573:Electrolytes / Q000097:blood; D005260:Female; D008297:Male; D012151:Resuscitation; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*; D012771:Shock, Hemorrhagic / Q000503:physiopathology / Q000628:therapy*
D004573:Electrolytes; D012462:Saline Solution, Hypertonic