title: Early antibody responses of cattle for foot-and-mouth disease quadrivalent double oil emulsion vaccine.
abstract: Foot-and-mouth disease (FMD) is an economically important disease of cloven-hoofed animals. The multiplicity of FMDV serotypes in animals poses a central problem in the policy of vaccination and is of much concern to health authorities. Hence it is the practice of vaccination with polyvalent vaccine for prophylactic measure. In the present report, we analysed the early antibody responses elicited by FMDV quadrivalent (FMDV O, A, C and Asia 1 serotypes) double emulsion (Montanide ISA 206) vaccines in cattle. We observed variations between various viral serotypes in eliciting early antibody response although neutralizing antibody response against all the four serotypes were detected as early as fourth day following vaccination. The duration of immunity also appeared to maintain for long period. The neutralizing antibody titres were maintained well above 2log(10) even after 6 months of vaccination irrespective of serotypes. Thus, allows the possibilities of two vaccinations per year for the maintenance of herd immunity.
authors.affiliation: Indian Veterinary Research Institute, Hebbal, Bangalore 560 024, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Patil
authors.forename: J
authors.initials: J
authors.lastname: Bayry
authors.forename: S P
authors.initials: SP
authors.lastname: Nair
authors.forename: S
authors.initials: S
authors.lastname: Gopalakrishna
authors.forename: C M
authors.initials: CM
authors.lastname: Sajjanar
authors.forename: L D
authors.initials: LD
authors.lastname: Misra
authors.forename: C
authors.initials: C
authors.lastname: Natarajan
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005536:Foot-and-Mouth Disease / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology*; D007114:Immunization / Q000662:veterinary*; D009500:Neutralization Tests / Q000662:veterinary; D014765:Viral Vaccines / Q000276:immunology* / Q000592:standards
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D014765:Viral Vaccines