[Lipid peroxidation and regulation of it in rat blood and liver under the experimental alimentary radionuclide effect].
Effect of alimentary radionuclide load (137Cs, 700 Bq for animal per day during 7, 14 and 22 days) on the lipid peroxidation intensity and blood and liver enzymatic and non-enzymatic antioxidant system in the Wistar male-rats was investigated. It was found that considerable change of antioxidant system activity in plasma and erythrocytes of experimental animals was already noticeable on the 7th day of radionuclide load. After 22 days of experiment the reliability of glutathione-dependent antioxidant system in blood was essentially decreased and lipid hydroperoxide content was increased. The increase of lipid peroxidation intensity was also found in the experimental animals liver but at the same time the activities of all studied enzymes of antioxidant system were significantly higher than they were in the control rats.
Nikitchenko
Iu V
IuV
Research Institute of Biology, Karazin Kharkov National University, Kharkov, Ukraine.
Roman'ko
M Ie
MIe
Dziuba
V M
VM
Fuks
P P
PP
D000818:Animals; D002588:Cesium Radioisotopes / Q000008:administration & dosage*; D004032:Diet; D005978:Glutathione / Q000378:metabolism; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D002588:Cesium Radioisotopes; D008055:Lipids; D005978:Glutathione