Monitoring glycosylation of therapeutic glycoproteins for consistency using highly fluorescent anthranilic acid.
Dhume
Shirish T
ST
Analytical Sciences Department, SmithKline Beecham, Research and Development, King of Prussia, PA, USA.
Ebert
Mary Beth
MB
Saddic
George N
GN
Anumula
Kalyan R
KR
D002240:Carbohydrate Sequence; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005456:Fluorescent Dyes / Q000378:metabolism*; D006023:Glycoproteins / Q000302:isolation & purification / Q000378:metabolism* / Q000627:therapeutic use; D006031:Glycosylation; D008969:Molecular Sequence Data; D062367:ortho-Aminobenzoates / Q000378:metabolism*
D005456:Fluorescent Dyes; D006023:Glycoproteins; D062367:ortho-Aminobenzoates; C031385:anthranilic acid