Myocardial preservation using Celsior solution in cardiac transplantation: early results and 5-year follow-up of a multicenter prospective study of 70 cardiac transplantations.
BACKGROUND
Several storage methods using a wide variety of extracellular or intracellular solutions applied either as continuous perfusion, intermittent perfusion, or simple immersion of the heart have been commonly used. We have performed a prospective randomized multicenter study of 70 cardiac transplantation recipients to evaluate the Celsior solution for cardiac preservation.


METHODS
Seventy consecutive patients were included in this trial and received a cardiac graft arrested and preserved with Celsior. The first follow-up period was 1 month. The mean age of the recipients was 49 years (range, 28 to 66 years), and 81.7% were male. The main disease was nonobstructive cardiomyopathy (64.3%). The age range of donors was between 14 and 56 years with a mean of 33 years. The majority of grafts (73%) were stored in 1 L of Celsior. A midterm follow-up at 5 years was performed and was 100% complete.


RESULTS
The operative mortality (<30-day) rate was 6 of 70 (8.6%). Sixty-three patients (90%) had at least satisfactory hemodynamic measurements on day 2. The first postoperative echocardiograms showed good myocardial performance for 90% of the grafts. Actuarial survival rate at 5 years was 75% +/- 5.1%.


CONCLUSIONS
The use of Celsior in cardiac transplantation was safe and very effective. This solution proved very valuable in at-risk patients.
Remadi
Jean-Paul
JP
Department of Anesthesiology, The G and R Laënnec University Hospital, Nantes, France. remadijean-paul@chu-amiens.fr
Baron
Olivier
O
Roussel
Jean C
JC
Al Habash
Oussana
O
Treilhaud
Michele
M
Despins
Philippe
P
Duveau
Daniel
D
Michaud
Jean-Luc
JL
D000328:Adult; D000368:Aged; D004187:Disaccharides; D004573:Electrolytes; D005260:Female; D005500:Follow-Up Studies; D005971:Glutamates; D005978:Glutathione; D016027:Heart Transplantation; D006639:Histidine; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008353:Mannitol; D008875:Middle Aged; D009206:Myocardium; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D011183:Postoperative Complications / Q000401:mortality; D011446:Prospective Studies; D015996:Survival Rate
C088453:Celsior; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D019188:Organ Preservation Solutions; D008353:Mannitol; D006639:Histidine; D005978:Glutathione