title: Preliminary assessment of intrahemispheric QEEG measures in bipolar mood disorders.
abstract: OBJECTIVE
  This study assessed the quantitative electroenchephalographic (QEEG) absolute power and coherence differences between a group of patients with bipolar I mood disorder (BMD I) and a group of patients with schizophrenia. We also examined the correlation between QEEG measures and family history of BMD.
  
  
  METHODS
  Using the National Institutes of Mental Health (NIMH) Global Rating Scale, we rated 18 adult inpatients with a DSM-III-R diagnosis of BMD I for the severity of the current episode. We also collected data on the family history of the illness. This group was then matched for age, sex, and handedness with an equal number of inpatients with a DSM-III-R diagnosis of schizophrenia. QEEG absolute power and coherence was calculated for the alpha bandwidth (8.0 to 12.0 Hz), assessed at 18 pairs of electrodes in both hemispheres during resting, eyes-closed condition in all the patients.
  
  
  RESULTS
  The patients with schizophrenia showed significantly higher coherence (P = 0.047) at 6 pairs of electrodes on the right side. The group with BMD showed significantly higher power (P = 0.042) at 2 pairs of electrodes on the right side. Correlational analysis showed that QEEG measures were significantly correlated (P = 0.01) with positive family history of BMD.
  
  
  CONCLUSIONS
  These findings suggest that the patients with BMD are more disorganized in the right anterior hemisphere and that there is a significant positive correlation between the QEEG measures and the presence of family history of BMD. Further studies in a larger sample are required to confirm these preliminary findings.
authors.affiliation: Clinical Rehabilitation Evaluation Unit (CREU), Acute Care Program, North Bay Psychiatric Hospital, PO Box 3010, HWY 11 N, North Bay, ON P1B 8L1. oloruntoba.oluboka@nbph.moh.gov.on.ca
authors.forename: O J
authors.initials: OJ
authors.lastname: Oluboka
authors.forename: S L
authors.initials: SL
authors.lastname: Stewart
authors.forename: V
authors.initials: V
authors.lastname: Sharma
authors.forename: D
authors.initials: D
authors.lastname: Mazmanian
authors.forename: E
authors.initials: E
authors.lastname: Persad
mesh_terms: D000328:Adult; D000513:Alpha Rhythm; D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D002908:Chronic Disease; D004292:Dominance, Cerebral / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D012815:Signal Processing, Computer-Assisted