title: Experimental study of the frontal sinus development on Goettingen miniature pigs.
abstract: According to the literature, the development of the frontal sinus cavity is a result of the active immigration of cells from the ethmoidal complex into the os frontale. This migration theory is in contrast to the operative outcome of Apert's syndrome patients, after fronto-orbital advancement. When a fronto-orbital advancement at the age of a few months is performed in these patients while the frontal suture is yet closed, a sinus developed even the distance between nasal root and frontal bone bing up to 2 cm. In order to study the development of the frontal sinus, an animal study on 12 five-week-old infant Goettingen minipigs (GMP) was conducted, which did not have any clinical or histological signs of a frontal sinus development to investigate the development of the frontal sinus in "orthotopically" transplanted frontal bone with an open frontal suture. A comparison was made to a control group. The macro- and microscopical comparison with a control group revealed that the orthotopical transplants in the occipital bone developed epithelium-lined sinus, beginning from the thirty-fifth week. Based on these histomorphological results, a development scheme for the genesis of the sinus frontalis as a model were drawn.
authors.affiliation: Department of Craniofacial and Plastic Surgery, University Hospital and Medical School of the Georg-August-University of Goettingen, Germany.
authors.forename: Johannes Franz
authors.initials: JF
authors.lastname: Hönig
authors.forename: Hans Albert
authors.initials: HA
authors.lastname: Merten
authors.forename: Rainer
authors.initials: R
authors.lastname: Schütte
authors.forename: Ulrike Anna
authors.initials: UA
authors.lastname: Grohmann
authors.forename: Antonio
authors.initials: A
authors.lastname: Cassisis
mesh_terms: D000818:Animals; D001860:Bone Plates; D001861:Bone Regeneration / Q000502:physiology; D002465:Cell Movement; D003393:Cranial Sutures / Q000166:cytology / Q000254:growth & development / Q000637:transplantation; D003399:Craniotomy; D005004:Ethmoid Bone / Q000166:cytology / Q000254:growth & development / Q000473:pathology; D005624:Frontal Bone / Q000166:cytology / Q000254:growth & development / Q000637:transplantation; D005626:Frontal Sinus / Q000254:growth & development* / Q000473:pathology; D023421:Models, Animal; D009777:Occipital Bone / Q000473:pathology / Q000601:surgery; D010012:Osteogenesis / Q000502:physiology; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors; D016042:Transplantation, Heterotopic