Solid-phase synthesis of thrombin inhibitors.
A newly developed convergent solid-phase synthesis provides efficient access to thrombin inhibitors of the D-Phe-Pro-Arg type. Members of the synthesized libraries inhibited thrombin with IC(50)s in the nanomolar range.
Lange
Udo E W
UE
BASF AG, D-67056 Ludwigshafen, Germany.
Zechel
Christian
C
D000991:Antithrombins / Q000138:chemical synthesis* / Q000378:metabolism; D001665:Binding Sites; D002851:Chromatography, High Pressure Liquid; D013056:Spectrophotometry, Ultraviolet; D013917:Thrombin / Q000378:metabolism
D000991:Antithrombins; D013917:Thrombin