Vitamins B6 and C and mitomycin C-efficiency under irradiation.
The radiation-induced effect of Vitamin B6 (Vit. B6) on mitomycin C (MMC) was investigated by using Escherichia coli bacteria AB 1157 as a model in air-free media as well as in media saturated with nitrous oxide (N20) or air, respectively. In all three types of media Vit.B6 showed cytostatic abilities. The highest synergistic effect of Vit.B6 on MMC was observed in an air-free environment. It decreased 2.8-fold in aerated solution and showed the opposite effect in solutions saturated with N20. The addition of Vitamin C (Vit.C) to the Vit.B6/MMC-mixture in air-free media reduced the MMC-efficiency by a factor of 3.6, whereas the presence of air led to a MMC enhancement of 1.6-fold. Considerations based on the involvement of the primary transients of water radiolysis were made in order to explain the observed effects.
Svoboda
Beatrice
B
Ludwig Boltzmann Institute for Radiation Chemistry and Radiation Biology, University of Vienna, Wien, Austria.
Getoff
Nikola
N
D000388:Air; D000693:Anaerobiosis; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D016685:Mitomycin / Q000494:pharmacology*; D009609:Nitrous Oxide / Q000737:chemistry / Q000378:metabolism; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D025101:Vitamin B 6 / Q000494:pharmacology*
D000903:Antibiotics, Antineoplastic; D011838:Radiation-Sensitizing Agents; D016685:Mitomycin; D025101:Vitamin B 6; D009609:Nitrous Oxide