Fully automated screening systems.
A fully automated system is one of the most valuable tools available for HTS. However, proper sourcing, installation and operation of an automated system requires a thorough inventory of your needs and a strong attention to detail in the implementation and operation. As you could see from the examples, assays can usually be transferred to an automated robotic system with minimum changes. However details must be reviewed to assure that the results will be consistent within a run and as compared to the same assay performed manually on the bench or on workstations. Validation is a crucial element to assure that the integrated system and the individual components are operating within their designated tolerances.
Cohen
Seth
S
Millenium Pharmaceuticals Inc., Cambridge, MA, USA.
Trinka
Robert F
RF
D001331:Automation / Q000295:instrumentation; D002176:Candida albicans; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation* / Q000379:methods; D008967:Molecular Biology / Q000295:instrumentation / Q000379:methods; D009172:Mycology / Q000379:methods; D015203:Reproducibility of Results; D012371:Robotics / Q000295:instrumentation