Integrin connections map: to infinity and beyond.
Integrins are transmembrane proteins that serve as primary sensors of the extracellular matrix (ECM) environment. In response to interactions with the ECM, integrins initiate signaling pathways that regulate cell migration, growth, and survival. Advances in imaging have contributed to the understanding of the dynamic nature of these cell-ECM interactions and the complexes that form at these sites and have provided insights into their regulation and signal organizing functions.
Martin
Karen H
KH
Department of Microbiology, University of Virginia Health System, Box 800734, Charlottesville, VA 22908-0734, USA.
Slack
Jill K
JK
Boerner
Scott A
SA
Martin
Clifford C
CC
Parsons
J Thomas
JT
D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D002448:Cell Adhesion; D002470:Cell Survival; D005109:Extracellular Matrix / Q000378:metabolism; D022001:Focal Adhesions / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D016023:Integrins; D018631:ras Proteins; D020741:rho GTP-Binding Proteins