[Potentiation of the cataractogenic effect of light by dimethylsulfoxide and adrenaline].
On the basis of the data about possible potentiation of polychromatic light cataractogenic effect by adrenaline and dimethylsulfoxide preparations, obtained by us earlier (increasing of animals number with changes of lenses and metabolic disturbances, of the first clinical signs of cataract in more earlier terms, more rapid development occurred in lenses opacities, more intensive changes of lenses substance), we have studied some biochemical parameters (peroxide resistance of erythrocyte, the level of free amine nitrogen, activity of Na,K-ATP-ase, gamma-glutamiltranspeptidase, ceruloplasmin) in blood, liver and tissues of rabbits eyes, during modelling of the light cataract on the background of supplementary application of adrenalin and dimethylsulfoxide. It was shown that one of the possible mechanisms of cocataractogenic action of the studied substances is the revealed fact of increasing the metabolic systems disturbances, caused by long-term irradiation of the animals.
Metelitsyna
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IP
Filatov Institute of Eye Diseases and Tissue Therapy, Academy of Medical Sciences of Ukraine, Odessa. metelirina@yahoo.com
D000818:Animals; D002386:Cataract / Q000139:chemically induced* / Q000201:enzymology; D004121:Dimethyl Sulfoxide / Q000009:adverse effects*; D004837:Epinephrine / Q000009:adverse effects*; D008027:Light; D011817:Rabbits
D004837:Epinephrine; D004121:Dimethyl Sulfoxide