title: Chemical studies of essential oils of Juniperus oxycedrus ssp. badia.
abstract: Leaf and (unripe and ripe) berry essential oils of Juniperus oxycedrus ssp. badia (H. Gay) Debeaux grown wild in Spain have been analysed by capillary GC and GC-MS in combination with retention indices. A seasonal investigation of both leaf and berry oils was also performed. Among the approximately 80 constituents investigated (representing 90-98% of the oils) 60-68 were identified (80-97% of the oil composition). The leaf oils were mainly composed of alpha-pinene (40-57%) and manoyl oxide (5-10%). The (unripe) berry oils were dominated by alpha-pinene (65%) with moderate amounts of myrcene, limonene, germacrene D or gamma-muurolene. Several differences in yields and chemical composition from a qualitative and quantitative point of view were detected when comparing all the oil samples analysed. In addition, two oil samples were examined, but found inactive, against the replication of HIV-1(III(B)) and HIV-2(ROD) in cell culture, whereas the samples were toxic for the cells at a 50% cytotoxic concentration of 106 and 123 microg/ml, respectively.
authors.affiliation: Departamento de Química Inorgánica y Orgánica, Facultad de Ciencias Experimentales, Universidad de Jaén, 23071 Jaén, Spain.
authors.forename: Sofía
authors.initials: S
authors.lastname: Salido
authors.forename: Joaquín
authors.initials: J
authors.lastname: Altarejos
authors.forename: Manuel
authors.initials: M
authors.lastname: Nogueras
authors.forename: Adolfo
authors.initials: A
authors.lastname: Sánchez
authors.forename: Christophe
authors.initials: C
authors.lastname: Pannecouque
authors.forename: Myriam
authors.initials: M
authors.lastname: Witvrouw
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D002849:Chromatography, Gas; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D005638:Fruit / Q000737:chemistry; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D018653:Juniperus / Q000737:chemistry*; D013058:Mass Spectrometry; D009822:Oils, Volatile / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D009822:Oils, Volatile