Multiple glucose 6-phosphate pools or channelling of flux in diverse pathways?
Glucose 6-phosphate is an intermediate of pathways of glucose utilization and production as well as a regulator of enzyme activity and gene expression. Studies on the latter functions are in part based on measurement of the glucose 6-phosphate content in a whole-cell extract. Several studies have suggested that there are multiple subcellular pools of glucose 6-phosphate. It is proposed that this data can be interpreted in terms of channelling of metabolic intermediates through multiple pathways of glucose metabolism with leakage of glucose 6-phosphate from the channels into a single free pool. It is also proposed that measurement of total tissue content of glucose 6-phosphate approximates the free pool.
Agius
Loranne
L
Department of Diabetes and Metabolism, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, U.K. Loranne.Agius@ncl.ac.uk
Centelles
Josep
J
Cascante
Marta
M
D000818:Animals; D001693:Biological Transport, Active; D005947:Glucose / Q000378:metabolism; D019298:Glucose-6-Phosphate / Q000378:metabolism*; D006003:Glycogen / Q000096:biosynthesis; D006019:Glycolysis; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D009132:Muscles / Q000378:metabolism; D013347:Subcellular Fractions / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D019298:Glucose-6-Phosphate; D006003:Glycogen; D005947:Glucose