[State of the opioid system in rats with different sensitivity to ethanol].
In this work we investigated the content of opioids in plasma blood and the changes caused by ethanol (1.5 g/kg, i.p.) in midbrain opioid receptors of rats with different sensitivity to ethanol, as determined according to the duration of ethanol-induced sleep (DEIS). A receptor binding technique with selective delta-DADLE and mu-DAGO radioligands were used. Ethanol even at low dose produced changes in the midbrain opioid receptors which appeared after 6 hours. The response of the receptors and the content of opioids in plasma blood of rats with different DEIS were not identical.
Pivovarchik
M V
MV
Institute of Biochemistry, National Academy of Sciences of Bylarus, Grodno. val@biochem.unibel.by
D000818:Animals; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000378:metabolism; D016308:Enkephalin, Leucine-2-Alanine / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000378:metabolism; D018847:Opioid Peptides / Q000097:blood*; D011869:Radioligand Assay; D051381:Rats; D011957:Receptors, Opioid / Q000378:metabolism
D018847:Opioid Peptides; D011957:Receptors, Opioid; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D000431:Ethanol; D016308:Enkephalin, Leucine-2-Alanine