title: Treatment of experimentally induced Pasteurella multocida infections in broilers and turkeys: comparative studies of different oral treatment regimens.
abstract: Experimental fowl cholera was induced in 60 healthy 10-week-old broiler chickens and 8-week-old turkeys by intramuscular inoculation with approximately 80 colony-forming units (cfu) of Pasteurella multocida X-73 strain and with approximately 70 cfu of P. multocida P-1059 strain, respectively. This method of infection proved to be useful for evaluating the efficacy of anti-microbial medication, by measuring mortality, weight gain, pathological responses and frequency of re-isolation of P. multocida. The efficacies of two different dosing methods, continuous and pulse dosing, were compared. Using the continuous-dosing method, norfloxacin was administered to drinking water at 100 mg/l for 5 days in chickens. Efficacies were slightly improved compared with pulse dosing at 15 mg/kg bodyweight for the same length of time. The opposite was observed in turkeys, to the degree of control of mortality and maintenance of weight gain.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, Budapest, Hungary. Gezas@hu.inter.net
authors.forename: G
authors.initials: G
authors.lastname: Sarközy
authors.forename: G
authors.initials: G
authors.lastname: Semjén
authors.forename: P
authors.initials: P
authors.lastname: Laczay
authors.forename: E
authors.initials: E
authors.lastname: Horváth
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002645:Chickens; D004334:Drug Administration Schedule; D005260:Female; D008297:Male; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010326:Pasteurella Infections / Q000188:drug therapy / Q000662:veterinary*; D016979:Pasteurella multocida / Q000187:drug effects; D011201:Poultry Diseases / Q000188:drug therapy*; D016896:Treatment Outcome; D014422:Turkeys
chemical_list: D000890:Anti-Infective Agents; D009643:Norfloxacin