Natural history of enteroaggregative and enterotoxigenic Escherichia coli infection among US travelers to Guadalajara, Mexico.
The natural history of enteroaggregative Escherichia coli (EAEC) and enterotoxigenic E. coli (ETEC) infection was studied among 40 US travelers who provided weekly stool samples for 4 weeks after arrival in Mexico. At enrollment, 5 subjects were colonized by EAEC and 3 by ETEC. During the first 2 weeks after enrollment, 12 developed EAEC diarrhea, 7 developed ETEC diarrhea (5 with mixed EAEC/ETEC diarrhea), 13 had EAEC colonization, and 7 had ETEC colonization. During the third and fourth weeks, 4 experienced EAEC diarrhea, 2 experienced ETEC diarrhea (1 with mixed EAEC/ETEC diarrhea), 31 had EAEC colonization, and none had ETEC colonization. Plasmid DNA analysis showed a high degree of heterogeneity among EAEC isolates. Symptomatic EAEC infection occurred early after arrival in Guadalajara, Mexico, and was as common as ETEC infection. Asymptomatic EAEC infection was recurrent.
Adachi
Javier A
JA
Center for Infectious Diseases, Medical School and School of Public Health, University of Texas-Houston, Houston, TX, USA.
Ericsson
Charles D
CD
Jiang
Zhi-Dong
ZD
DuPont
Margaret W
MW
Pallegar
Sanjay R
SR
DuPont
Herbert L
HL
D000293:Adolescent; D000328:Adult; D001422:Bacterial Adhesion; D001427:Bacterial Toxins / Q000096:biosynthesis*; D003967:Diarrhea / Q000382:microbiology / Q000503:physiopathology; D004768:Enterotoxins / Q000096:biosynthesis*; D004926:Escherichia coli / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000382:microbiology* / Q000503:physiopathology*; D029968:Escherichia coli Proteins; D005243:Feces / Q000382:microbiology; D006801:Humans; D008800:Mexico; D014195:Travel; D014481:United States
D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; C034151:heat stable toxin (E coli)