title: Heterotopic shift of epithelial-mesenchymal interactions in vertebrate jaw evolution.
abstract: Genes involved in late specification of the mandibular arch, the source of the vertebrate jaw, are expressed with similar patterns in the oral regions of chick and lamprey embryos. However, morphological comparisons indicate that apparently orthologous homeobox genes were expressed in different subdivisions of the ectomesenchyme in the two species. Therefore, the homology and gene expression of the oral region are uncoupled during the transition from agnathan to gnathostome; we conclude that a heterotopic shift of tissue interaction was involved in the evolution of the jaw.
authors.affiliation: Laboratory for Evolutionary Morphology, Center for Developmental Biology, RIKEN, Hyogo 650-0047, Japan.
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Shigetani
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Sugahara
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Murakami
authors.forename: Shigeki
authors.initials: S
authors.lastname: Hirano
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kuratani
mesh_terms: D000818:Animals; D005075:Biological Evolution; D019521:Body Patterning; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000494:pharmacology / Q000502:physiology; D001921:Brain / Q000196:embryology / Q000378:metabolism; D002642:Chick Embryo; D004817:Epidermis / Q000196:embryology / Q000378:metabolism; D004848:Epithelium / Q000196:embryology / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000494:pharmacology / Q000502:physiology; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007568:Jaw / Q000033:anatomy & histology / Q000196:embryology; D007798:Lampreys / Q000196:embryology* / Q000235:genetics; D008046:Lip / Q000196:embryology / Q000378:metabolism; D008334:Mandible / Q000033:anatomy & histology / Q000196:embryology*; D008648:Mesoderm / Q000378:metabolism / Q000502:physiology*; D008969:Molecular Sequence Data; D009055:Mouth / Q000196:embryology / Q000378:metabolism; D009432:Neural Crest / Q000196:embryology / Q000502:physiology; D010802:Phylogeny; D014157:Transcription Factors
chemical_list: D019485:Bone Morphogenetic Proteins; C088334:Distal-less homeobox proteins; D018398:Homeodomain Proteins; D014157:Transcription Factors; D005346:Fibroblast Growth Factors