[Acute urinary complications after prostate iodine-125 brachytherapy: evaluation and risk factors].
OBJECTIVE
Evaluation of acute urinary toxicity following prostate Iodine-125 brachytherapy and determination of risk factors.


METHODS
Between September 2000 and July 2001, 50 men were entered into the study. A clinical follow-up accompanied by an objective measurement of urinary morbidity, including uroflowmetry and post-void residue, enabled the evaluation of acute toxicity before and then at one, three and six months of the implantation. Predictors were also searched for.


RESULTS
38 (76%) patients developed urinary disorders but those remained minor or moderate. The IPSS, as well as uroflowmetry deteriorated significantly at the first and third month post-implant, before improving during the sixth month. Besides, the variations of the post-void residue were less significant. Concerning the factors of risk, an initial IPSS superior to eight and a prior alpha-blocker treatment were the preoperative identified risk factors. Regarding dosimetric parameters, preoperative U30 and postoperative D90, D95, V100, V150 and V200 were identified.


CONCLUSIONS
Though remaining minor or moderate, the great frequency of acute urinary toxicity following prostate brachytherapy requires frank and open dialogue with the patient in conjunction with an evaluation of the urinary status before implantation Patients with higher initial IPSS or having required a prior alpha-blocker treatment are more exposed to these disorders and their correlated postoperative dosimetric factors.
Mallick
S
S
Service d'urologie, CHU, hôpitaux de Brabois, 54511 Vandoeuvre-lès-Nancy, France. mallick@caramail.com
Azzouzi
R
R
Bey
P
P
Cormier
L
L
Moreau
J L
JL
Peiffert
D
D
Mangin
P
P
D000208:Acute Disease; D001918:Brachytherapy / Q000009:adverse effects; D003131:Combined Modality Therapy; D004452:Echocardiography; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D011832:Radiation Injuries / Q000209:etiology; D011879:Radiotherapy Dosage; D014555:Urination Disorders / Q000209:etiology*
D007457:Iodine Radioisotopes