title: [Colitis ulcerosa and opioid addiction].
abstract: The occurrence of an opioid addiction within an opioid treatment of pain or diarrhoea in inflammatory bowel disease is rarely reported. We report on a 36-year-old male with a 14 years lasting left sided chronic ulcerative colitis who developed after the initiation of a therapy with tincture of opium because of abdominal pain and diarrhoea an opioid addiction with the consumption of opium and later buprenorphin. Additionally to the diagnostics and therapy of the ulcerative colitis a detoxication was carried out. The diarrhoea slightly increased during the buprenorphin withdrawal. Diarrhoea refractory to other treatment should be treated by loperamid because of its lacking effects on the central nervous system. In chronic abdominal or musculoskeletal pain in inflammatory bowel disease opioids can be used if no surgical or other medical pain relief is possible. A consequent control of the therapeutic and side effects of the opioid therapy is necessary, especially of an abuse of opioid medication. The published case reports of a therapeutic induction of opioid addiction demonstrate that psychiatric comorbidity is an essential or even necessary risk factor. A checklist with seven criteria of opioid addiction during opioid therapy is presented.
authors.affiliation: Medizinische Klinik I, Klinikum Saarbrücken gGmbH, Saarbrücken, Germany. w.haeuser@klinikum-saarbruecken.de
authors.forename: W
authors.initials: W
authors.lastname: Häuser
authors.forename: H
authors.initials: H
authors.lastname: Lachiheb
authors.forename: D
authors.initials: D
authors.lastname: Grandt
mesh_terms: D015746:Abdominal Pain / Q000188:drug therapy* / Q000209:etiology; D000328:Adult; D002047:Buprenorphine / Q000008:administration & dosage* / Q000009:adverse effects; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D003131:Combined Modality Therapy; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D009293:Opioid-Related Disorders / Q000209:etiology* / Q000534:rehabilitation; D009892:Opium / Q000008:administration & dosage* / Q000009:adverse effects; D012651:Self Medication; D013375:Substance Withdrawal Syndrome / Q000534:rehabilitation / Q000628:therapy
chemical_list: D002047:Buprenorphine; D009892:Opium