title: Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3.
abstract: We describe here two mouse mutants, yellow submarine (Ysb) and light coat and circling (Lcc). Ysb arose as the result of insertions of a transgene, pAA2, into the genome. Lcc is an independent, radiation-induced mutation. Both mutants are characterized by recessive circling behavior and deafness, associated with a non-segregating, semi-dominant yellow coat color. Complementation tests showed that Ysb and Lcc are allelic. We attribute the yellow coat in Ysb and Lcc mice to the absence of black awl overhairs, increased agouti zigzag underhairs, and the presence of agouti awls with long subapical yellow pigment. Chromosomal mapping and genomic characterization showed the Ysb and Lcc mutations involve complex chromosomal rearrangements in overlapping regions of mouse chromosome 3, A2/A3-B/C and B-E1, respectively. Ysb and Lcc show for the first time, to our knowledge, the presence of genes in the B-C region of chromosome 3 important for balance and hearing and the pigmentation and specification of coat hair.
authors.affiliation: Department of Biochemistry, University of Hong Kong, 5 Sassoon Road, Hong Kong SAR, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Dong
authors.forename: Keith K H
authors.initials: KK
authors.lastname: Leung
authors.forename: Anna L
authors.initials: AL
authors.lastname: Pelling
authors.forename: Patrick Y T
authors.initials: PY
authors.lastname: Lee
authors.forename: Anna S P
authors.initials: AS
authors.lastname: Tang
authors.forename: Henry H Q
authors.initials: HH
authors.lastname: Heng
authors.forename: Lap C
authors.initials: LC
authors.lastname: Tsui
authors.forename: Charles
authors.initials: C
authors.lastname: Tease
authors.forename: Graham
authors.initials: G
authors.lastname: Fisher
authors.forename: Karen P
authors.initials: KP
authors.lastname: Steel
authors.forename: Kathryn S E
authors.initials: KS
authors.lastname: Cheah
mesh_terms: D000818:Animals; D003638:Deafness / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000528:radiation effects; D010858:Pigmentation / Q000235:genetics* / Q000528:radiation effects; D004856:Postural Balance / Q000502:physiology / Q000528:radiation effects; D013239:Stereotyped Behavior / Q000528:radiation effects