title: Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics.
abstract: Inspired by the structure of tannic acid, first- to third-generation dendrimers containing two, four, and eight galloyl moieties were synthesized. Stability, antioxidant activity and collagen cross-linking activity of the natural product and its dendrimer analogues were compared. The experimental results indicate that polygalloyl dendrimers might be used as new lead compounds to improve the long-term healing characteristics of burn wounds.
authors.affiliation: Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
authors.forename: S Bart A
authors.initials: SB
authors.lastname: Halkes
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vrasidas
authors.forename: Gilbert R
authors.initials: GR
authors.lastname: Rooijer
authors.forename: Albert J J
authors.initials: AJ
authors.lastname: van den Berg
authors.forename: Rob M J
authors.initials: RM
authors.lastname: Liskamp
authors.forename: Roland J
authors.initials: RJ
authors.lastname: Pieters
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D005707:Gallic Acid / Q000737:chemistry*; D047348:Hydrolyzable Tannins / Q000737:chemistry* / Q000494:pharmacology; D018716:Molecular Mimicry
chemical_list: D000975:Antioxidants; D047348:Hydrolyzable Tannins; D005707:Gallic Acid