[Synthesis and antibacterial activity of 7-substituted-1-ethyl(2-fluoro-ethyl)-6,8-difluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid].
Eighteen 7-substituted-1-ethyl (2-fluoroethyl)-6, 8-difluoro-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid were designed and synthesized. The results of preliminary antibacterial test showed that most of the compounds exhibited definite activities in test against pathogenic bacteria. Especially, compound 17 and 18 showed better activities and surpassed fleroxacin when compared in vitro.
Yan
L
L
Shenyang Military District, Institute of Military Medicine, Shenyang 110031.
Xu
B
B
Ma
Z
Z
Zhu
Y
Y
Yang
Q
Q
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D016576:Fleroxacin / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects; D015394:Molecular Structure
D000890:Anti-Infective Agents; D016576:Fleroxacin