title: Synthesis and bioactivities of novel 4,5,6,7-tetrahydrothieno[2,3-c]pyridines as inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.
abstract: Novel 4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives were synthesized and evaluated for their abilities to inhibit lipopolysaccharide (LPS)-stimulated production of TNF-alpha in rat whole blood. Several of these compounds exhibited potent inhibitory activity.
authors.affiliation: Omiya Research Laboratory, Nikken Chemicals Co., Ltd., 1-346, Kitabukuro-cho, Saitama-shi, Saitama 330-0835, Japan. mfujita-nikken@nifty.com
authors.forename: Masakazu
authors.initials: M
authors.lastname: Fujita
authors.forename: Taketsugu
authors.initials: T
authors.lastname: Seki
authors.forename: Haruaki
authors.initials: H
authors.lastname: Inada
authors.forename: Naoko
authors.initials: N
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D011725:Pyridines; D014409:Tumor Necrosis Factor-alpha