Ceftriaxone-induced haemolytic anaemia in a child with no immune deficiency or haematological disease.
A 5-year-old girl, with no underlying immune deficiency or haematologic disease, was treated with ceftriaxone for a urinary tract infection. After receiving ceftriaxone intramuscularly, massive haemolytic anaemia developed. Laboratory studies showed the presence of an antibody against ceftriaxone, and the findings reflected immune complex type haemolysis. High-dose corticosteroids appeared to be effective therapeutically.
Citak
A
A
University of Istanbul, Institute of Child Health, Pediatric Emergency Department, Istanbul, Turkey. agopcitak@hotmail.com
Garratty
G
G
Ucsel
R
R
Karabocuoglu
M
M
Uzel
N
N
D000583:Amikacin / Q000008:administration & dosage; D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000188:drug therapy; D000936:Antigen-Antibody Complex; D002443:Ceftriaxone / Q000009:adverse effects*; D002511:Cephalosporins / Q000009:adverse effects*; D002675:Child, Preschool; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D014481:United States; D014552:Urinary Tract Infections / Q000188:drug therapy
D000936:Antigen-Antibody Complex; D002511:Cephalosporins; D002443:Ceftriaxone; D000583:Amikacin; D008775:Methylprednisolone