title: [Monosomy 1p and alkaline phosphatase in meningiomas. Citopathological, histochemical and genetical study in 10 tumors].
abstract: BACKGROUND
  Cytogenetic studies in meningiomas show that 1p monosomy constitutes an important factor involved in their progression. Genes coding for unspecific alkaline phosphatase (AP-un) are located in this chromosome, in particular in 1p34-p36.1. This enzyme is widely distributed in the body and it is also found in meningiomas. The loss of expression of this enzyme in meningiomas has been associated with the presence of 1p monosomy in these tumors.
  
  
  METHODS
  We studied 10 meningiomas from 8 patients which shared 1p monosomy. Three tumors had a benign morphologic pattern; it was atypical in two and malignant in five cases. We performed a cytogenetic study and FISH as well as a determination of AP-un in tumor cells.
  
  
  RESULTS
  In 8 of ten cases, a loss of AP-un expression was observed. One case displayed positivity in 20% cells. In a positive case, activity was demonstrated in 80% cells.
  
  
  CONCLUSIONS
  Our work aimed at analysing the relationship between loss of expression of AP-un, 1p monosomy and the aggressiveness of meningioma. Our results back the interest in determining this enzyme in tumor cells as a quick method with important prognostic value.
authors.affiliation: Departamentos de Patología, Facultad de Medicina, Hospital Clínico Universitario, Universidad de Valencia, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Cerdá-Nicolás
authors.forename: Concha
authors.initials: C
authors.lastname: López-Ginés
authors.forename: Miguel
authors.initials: M
authors.lastname: Pérez-Bacete
authors.forename: Fernando
authors.initials: F
authors.lastname: Talamantes
authors.forename: Pedro
authors.initials: P
authors.lastname: Roldán
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000235:genetics*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology*; D008579:Meningioma / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D009006:Monosomy / Q000235:genetics*
chemical_list: D000469:Alkaline Phosphatase