title: Effect of isotonic and hypotonic lactated ringer's solutions with dextrose intravenously administered to dehydrated heifers.
abstract: To determine the effects of rapid infusion of essential fluids in a volume of hypotonic lactated Ringer's solution, the central venous pressure (CVP) and acid-base equilibrium were investigated in to mildly dehydrated heifers. Mild dehydration was induced in 9 Holstein heifers by withholding food and water until 7.0+/-5.7% of plasma volume had been lost. The heifers were randomly assigned to the ILG (lactated Ringer's + 5% dextrose), HLG (1/2 lactated Ringer's + 2.2% dextrose) or HRG (1/2 Ringer's + 2.5% dextrose) groups with 3 heifers in each group. Heifers received 30 ml/kg of one of the fluids, at a flow rate of 20 ml/kg/hr. The rapid intravenous (IV) infusions of HLG and HRG used in this study were found to be safe and effective in increasing plasma volume without increasing CVP, even though the infusion was given to the jugular vein at a dosage of 30 ml/kg. However, ILG infusion induced progressive increases in CVP, reaching 9.0+/-2.0 mmHg. No clinical signs, such as moist rales on auscultation, moist cough, jugular vein congestion, ophthalmoptosis, salivation or arrhythmia, were observed throughout the fluid infusion. The relative changes in base excess (rBE) for the ILG and HRG groups were significantly decreased until the end of fluid infusion. As for the HLG group, rBE slightly decreased until the end of the fluid infusion. Then the values significantly increased and exceeded the pre-infusion value at the end of the experiment. While IV infusion of HLG inhibited acidification caused by dilution, HRG infusion induced diluted acidification. It is suggested that HLG infusion should be examined as a treatment for cattle with dehydration and moderate metabolic acidosis, since rapid infusion of HLG may be more beneficial for rehydrating cattle with metabolic acidosis than current treatment.
authors.affiliation: Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Junko
authors.initials: J
authors.lastname: Okumura
authors.forename: Izumi
authors.initials: I
authors.lastname: Abe
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Iwabuchi
authors.forename: Kiichi
authors.initials: K
authors.lastname: Kanayama
authors.forename: Ryuji
authors.initials: R
authors.lastname: Asano
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D003681:Dehydration / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007038:Hypotonic Solutions; D007262:Infusions, Intravenous / Q000662:veterinary; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D000077325:Ringer's Lactate
chemical_list: D006454:Hemoglobins; D007038:Hypotonic Solutions; D007552:Isotonic Solutions; D000077325:Ringer's Lactate