title: [Chymase, tonin and elastase in rat tissue under oxidative stress caused by administering cobalt chloride].
abstract: Character of chymase, tonin and elastase activities changes in rats heart, lungs, liver, kidney under the oxidative stress, induced by cobalt chloride, was investigated. The elastase activity increase in the researched organs and all proteinase indicated in liver were revealed. The specific effect of tonin involvement in injuring effect of cobalt chloride in rat heart is shown, this effect is revealed by local absence of chymase level change, that is determined by its species unsimilarity compare with human. The conclusion about more essential significance of elastase and chymase in injuring effect in lungs and kidneys tissues is made.
authors.affiliation: Institute of Therapy, Academy of Medical Sciences of Ukraine, Kharkov.
authors.forename: L M
authors.initials: LM
authors.lastname: Samokhina
authors.forename: A A
authors.initials: AA
authors.lastname: Samokhin
mesh_terms: D000818:Animals; D053818:Chymases; D003035:Cobalt / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D018384:Oxidative Stress; D010196:Pancreatic Elastase / Q000378:metabolism*; D051381:Rats; D012697:Serine Endopeptidases / Q000378:metabolism*; D020840:Tissue Kallikreins / Q000378:metabolism*
chemical_list: D003035:Cobalt; D012697:Serine Endopeptidases; C117017:tonin; D020840:Tissue Kallikreins; D010196:Pancreatic Elastase; D053818:Chymases; C018021:cobaltous chloride