title: Prognostic factors in non-small cell lung carcinoma.
abstract: This review aims in presenting the established and putative prognostic markers in non-small cell lung carcinoma (NSCLC). We have focused on the molecular/genetic alterations accompanying the pathogenesis of this malignancy, which may derange the cellular response to external and internal stimuli. A variety of factors influencing cell cycle progression, programmed cell death, drug resistance and immune evasion seem to obtain a predictive--though sometimes argued--role. Taking into account that a great number of these factors develope "cross-talking" protein-complex networks, their combined evaluation is likely to contribute towards a more accurate prediction of the clinical outcome in NSCLC patients.
authors.affiliation: Department of Histology and Embryology, School of Medicine, University of Athens, Greece.
authors.forename: Marilena K
authors.initials: MK
authors.lastname: Koutsami
authors.forename: Vassilis G
authors.initials: VG
authors.lastname: Gorgoulis
authors.forename: Nikolaos G
authors.initials: NG
authors.lastname: Kastrinakis
authors.forename: Panayiotis J
authors.initials: PJ
authors.lastname: Asimacopoulos
authors.forename: Christos
authors.initials: C
authors.lastname: Kittas
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D011379:Prognosis