[Chemokines a hope of specific anti-inflammatory treatment].
Inflammation is a serious medical problem that causes suffering in many common diseases such as rheumatoid arthritis and asthma. Despite the fact that the clinical signs of inflammation--rubor, tumor, calor and dolor--have been known for almost two thousand years, our knowledge of the molecular pathways that mediate inflammation is still limited. Today's anti-inflammatory drugs are non-specific and have many undesirable side effects. The discovery of chemokines as small specific regulatory proteins of the immune system has increased our understanding of the inflammatory process. We have reason to believe that chemokines and their receptors are going to be targets for a new kind of anti-inflammatory therapy.
Schedvins
Per
P
Reumatologiska forskningslaboratoriet, institutionen för medicin, Karolinska sjukhuset, Stockholm.
Hjelmström
Peter
P
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D018925:Chemokines / Q000276:immunology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology; D018919:Neovascularization, Physiologic / Q000276:immunology; D019707:Receptors, Chemokine / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology
D000893:Anti-Inflammatory Agents; D018925:Chemokines; D019707:Receptors, Chemokine