title: [Report of a patient with spontaneous aggregation of his giant and morphologically abnormal platelets].
abstract: OBJECTIVE
  To study the pathological and clinical characteristics of a patient with spontaneous platelet aggregation of his giant and morphologically abnormal platelets.
  
  
  METHODS
  Platelet size and structure were observed under light microscope and electron microscope. Platelet aggregation was measured turbidometrically. Platelet glycoproteins (GP) were analyzed using flow cytometry. PCR and DNA sequencing were performed to identify the gene abnormality.
  
  
  RESULTS
  The patient had spontaneous platelet aggregation of giant platelets with thickened plasma membrane and increased number of granules in various shapes. Aspirin and ticlopidine did not affect the spontaneous aggregation. The expression of GP I b, GP II b, GP III a and P-selectin in the platelet membrane were in normal range. Results of gene analyses for GP I balpha, GP I bbeta and GPIX were also normal.
  
  
  CONCLUSIONS
  Both morphological and functional abnormalities of the platelets from the patient were clearly distinguishable from that of other hereditary giant platelet disorders. It would probably represent a novel platelet disorder which had not been reported to date.
authors.affiliation: Jiangsu Institute of Hematology, The First Affiliated Hospital of Suzhou University, Suzhou 215006, China.
authors.forename: Zhaoyue
authors.initials: Z
authors.lastname: Wang
authors.forename: Jumei
authors.initials: J
authors.lastname: Shi
authors.forename: Yue
authors.initials: Y
authors.lastname: Han
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Wang
authors.forename: Xia
authors.initials: X
authors.lastname: Bai
authors.forename: Dingwei
authors.initials: D
authors.lastname: Lu
authors.forename: Changgeng
authors.initials: C
authors.lastname: Ruan
mesh_terms: D001241:Aspirin / Q000494:pharmacology; D001606:Bernard-Soulier Syndrome / Q000378:metabolism / Q000473:pathology*; D001791:Blood Platelet Disorders / Q000378:metabolism / Q000473:pathology*; D048429:Cell Size / Q000502:physiology; D002648:Child; D003594:Cytoplasmic Granules / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D010980:Platelet Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D013988:Ticlopidine / Q000494:pharmacology
chemical_list: D010975:Platelet Aggregation Inhibitors; D010980:Platelet Membrane Glycoproteins; D013988:Ticlopidine; D001241:Aspirin