title: [Serratia marcescens vaccine in the treatment of malignant pleural effusion].
abstract: OBJECTIVE
  To evaluate the efficacy and toxicity of Serratia marcescens (S311) vaccine in the treatment of malignant pleural effusion.
  
  
  METHODS
  Thirty-four patients with malignant pleural effusion were given S311 as intrapleural injection with a dose of 10(9) U (0.32 mg) on D 1, 8 and 15, and observed for four weeks.
  
  
  RESULTS
  The overall response rate (CR + PR) was 97.1% (CR in 12 patients and PR in 21 patients). The systemic toxicity was mild, including fever (82.4%), pleuritic pain (50.7%), nansea (26.5%), dyspnea (17.5%) and chills (5.9%).
  
  
  CONCLUSIONS
  Serratia marcescens vaccine is effective for malignant pleural effusion, with tolerable toxic effects. Further study is warranted.
authors.affiliation: Beijing Thoracic Tumour and Tuberculosis Hospital, Beijing 101149, China.
authors.forename: Heling
authors.initials: H
authors.lastname: Shi
authors.forename: Yunzhong
authors.initials: Y
authors.lastname: Zhu
authors.forename: Liyan
authors.initials: L
authors.lastname: Xu
authors.forename: Zhe
authors.initials: Z
authors.lastname: Liu
authors.forename: Yonghong
authors.initials: Y
authors.lastname: You
authors.forename: Qiyi
authors.initials: Q
authors.lastname: Meng
authors.forename: Xinyong
authors.initials: X
authors.lastname: Zhang
authors.forename: Juntao
authors.initials: J
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001428:Bacterial Vaccines / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D002637:Chest Pain / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000188:drug therapy* / Q000276:immunology; D012706:Serratia marcescens / Q000276:immunology*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001428:Bacterial Vaccines