title: Markers of chronic inflammation and obesity: a prospective study on the reversibility of this association in middle-aged women undergoing weight loss by surgical intervention.
abstract: BACKGROUND
  Human adipose tissue expresses and releases proinflammatory cytokines and these measures of chronic inflammation have recently been associated with obesity.
  
  
  OBJECTIVE
  To test whether the proinflammatory state is reversible in subjects undergoing weight loss by surgical measures.
  
  
  METHODS
  Twenty morbidly obese women participated in this prospective study. Subjects were examined for fat mass, high-sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) before and 1 y after Swedish adjustable gastric banding.
  
  
  RESULTS
  Anthropometric measures displayed a significant reduction of the body mass index (BMI) from 41.6+/-5.4 to 30.8+/-6.1 kg/m(2) and the fat mass from 53.9+/-10.3 to 29.8+/-12.1 kg (mean+/-s.d.). Hs-CRP levels decreased significantly from 1.33+/-1.21 mg/dl in pre-gastric banding subjects to 0.40+/-0.61 mg/dl in post-gastric banding subjects, respectively. IL-6 and TNF-alpha levels did not differ significantly between pre- and post-gastric banding subjects.
  
  
  CONCLUSIONS
  We speculate that in these patients the marked reduction in C-reactive protein might be beneficial in reducing their cardiovascular risk and is not solely mediated by IL-6 and TNF-alpha.
authors.affiliation: Universitätsklinik für Innere Medizin, Universität Innsbruck, Innsbruck, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Laimer
authors.forename: C F
authors.initials: CF
authors.lastname: Ebenbichler
authors.forename: S
authors.initials: S
authors.lastname: Kaser
authors.forename: A
authors.initials: A
authors.lastname: Sandhofer
authors.forename: H
authors.initials: H
authors.lastname: Weiss
authors.forename: H
authors.initials: H
authors.lastname: Nehoda
authors.forename: F
authors.initials: F
authors.lastname: Aigner
authors.forename: J R
authors.initials: JR
authors.lastname: Patsch
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001823:Body Composition; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D005260:Female; D015391:Gastroplasty; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000601:surgery*; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D007328:Insulin; D015850:Interleukin-6; D020738:Leptin; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D002784:Cholesterol