[alpha-Tocopherol increases phosphorylation of rat nuclear proteins, catalyzed by protein kinase C].
alpha-Tocopherol added in vivo increased protein kinase C--dependent phosphorylation of rat liver nuclei proteins. Such effect of tocopherol was found also after the addition of sphingosine known as natural inhibitor of protein kinase C to incubation medium. The stimulation of phosphorilation was observed also after the addition of alpha-tocopherol to the Triton X-100 solubilized nuclear fraction which contained protein kinase C and tocopherol-binding proteins.
Petrova
G V
GV
Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
Donchenko
G V
GV
D000818:Animals; D001345:Autoradiography; D002384:Catalysis; D009687:Nuclear Proteins / Q000378:metabolism*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D024502:alpha-Tocopherol / Q000494:pharmacology*
D009687:Nuclear Proteins; D011493:Protein Kinase C; D024502:alpha-Tocopherol