title: Fatal haemophagocytic syndrome.
abstract: A fulminant clinical presentation with high fever and hepatosplenomegaly, together with a course of worsening pancytopenia, coagulopathy and liver failure, is suggestive of the haem syndrome (HPS). Bone marrow examination is diagnostic. We present 3 cases of HPS associated with different aetiologies including acute Ebstein Barr virus infection, T cell lymphoma, and malignant histiocytosis. In all the cases, the diagnosis was made late and the patients succumbed before definitive therapy could be administered.
authors.affiliation: Division of Clinical Haematology and Stem Cell Transplantation, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur.
authors.forename: S A
authors.initials: SA
authors.lastname: Fadilah
authors.forename: A A
authors.initials: AA
authors.lastname: Raymond
authors.forename: S K
authors.initials: SK
authors.lastname: Cheong
authors.forename: M A
authors.initials: MA
authors.lastname: Amir
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D015616:Histiocytosis, Non-Langerhans-Cell / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged