Impact of N-chlorotaurine on viability and production of secreted aspartyl proteinases of Candida spp.
N-Chlorotaurine, an endogenous long-lived oxidant, demonstrated fungicidal activity against Candida spp. and a postantifungal effect. Secreted aspartyl proteinases, important fungal virulence factors, proved to be a first target of impact. These results provide support for the topical application of N-chlorotaurine as an antimicrobial agent in yeast infections.
Nagl
Markus
M
Institute of Hygiene and Social Medicine, Leopold-Franzens-University of Innsbruck, Innsbruck, Austria. m.nagl@uibk.ac.at
Gruber
Andreas
A
Fuchs
Anita
A
Lell
Claudia P
CP
Lemberger
Eva-Maria
EM
Borg-Von Zepelin
Margarete
M
Würzner
Reinhard
R
D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D002175:Candida / Q000187:drug effects* / Q000201:enzymology* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D011480:Protease Inhibitors / Q000494:pharmacology*; D013654:Taurine / Q000031:analogs & derivatives / Q000494:pharmacology*
D011480:Protease Inhibitors; D013654:Taurine; C043410:N-chlorotaurine; D016282:Aspartic Acid Endopeptidases