[Plerosis of cDNA array of normal human nasopharyngeal tissue and nasopharyngeal carcinoma].
OBJECTIVE
To compare gene expression gene profile of nasopharyngeal carcinoma (NPC) tissue with that of normal nasopharyngeal tissues by cDNA array and to discuss possible functions of DNA repair-related genes in NPC tissue.


METHODS
After hybridization of atlas human cancer cDNA expression array 7742 - 1, atlas hybridization results were analyzed by Atlas Image 1.01 a software package. Using RT-PCR was used to confirm the results.


RESULTS
Of 63 differentially expressed genes in quadrangle C including DNA damage response, repair & recombination-related genes, 6 DNA repair-related genes were up-regulated, 12 were down-regulated.


CONCLUSIONS
DNA repair-related genes may be involved in patho-physiological process of nasopharyngeal carcinoma.
Han
Weinong
W
Laboratory of Cancerous Change and Invasion, Xiangya Medical College, Central South University, Changsha 410078, China.
Li
Hong
H
Xie
Lu
L
Xu
Liangguo
L
Zhang
Ling
L
Yao
Kaitai
K
D004260:DNA Repair / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D009305:Nasopharynx / Q000378:metabolism* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012334:RNA, Neoplasm / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
D012334:RNA, Neoplasm