title: Multifocal choroiditis after allogenic bone marrow transplantation.
abstract: OBJECTIVE
  To describe the clinical manifestations of multifocal choroiditis presumed to be secondary to allogenic bone marrow transplantation after development of self-tolerance to chronic graft-versus-host disease (GVHD).
  
  
  METHODS
  Case report. A 17-year-old male who received an allogenic bone marrow transplant (BMT) from his HLA-identical sister.
  
  
  RESULTS
  One year after BMT, grade II chronic GVHD developed. Two years later, vision deteriorated to 20/50 R.E. and 20/400 L.E. Ophthalmoscopic examination showed multiple chorioretinal punched-out scars throughout the posterior pole and mid-periphery of both eyes. Fluorescein angiography showed four choroidal neovascular membranes (CNVMs) in the right eye that were surgically removed, and a subfoveal disciform scar in the left eye.
  
  
  CONCLUSIONS
  Multifocal choroiditis is a possible complication related to allogenic BMT. It should be included as a late cause of BMT-associated choroidopathy. Surgical removal of vision-threatening CNVMs is a reasonable approach.
authors.affiliation: Department of Ophthalmology, Ramón y Cajal University Hospital, Madrid, Spain.
authors.forename: M T
authors.initials: MT
authors.lastname: Alvarez
authors.forename: J M
authors.initials: JM
authors.lastname: Hernáez
authors.forename: E
authors.initials: E
authors.lastname: Ciancas
authors.forename: M S
authors.initials: MS
authors.lastname: Figueroa
mesh_terms: D000293:Adolescent; D015551:Autoimmunity; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D020256:Choroidal Neovascularization / Q000209:etiology / Q000601:surgery; D002833:Choroiditis / Q000209:etiology* / Q000473:pathology; D005451:Fluorescein Angiography; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D016399:Lymphoma, T-Cell / Q000628:therapy; D008297:Male; D014184:Transplantation, Homologous; D014792:Visual Acuity