title: [High risk Wilms' tumor in children. Clinico-pathological correlation based on 320 patients registered in the Polish Paediatric Solid Tumor Study Group].
abstract: The records of 320 patients treated for Wilms' tumour in the first Wilms' Tumour Study (01-92 schedule) were reviewed and 42 children (13,86%) with unfavourable histology (UH) tumours were identified. There were 18 boys and 24 girls. Diffuse anaplasia was found in 26 patients (61,9%), focal anaplasia in 10 children (23,8%), CCSK and MRT were diagnosed in 3 patients each (7,1%). Clinical stages were: CS I - 5 (11,9%) patients, CS II N(-) - 7 (16,7%), CS II N(+) - 9 (21,4%), CS III - 15 (35,7%), CS IV - 5 (11,9%) and CS V - 1 patient (2,4%). Local and metastatic relapses of the disease occurred in 18 patients (43%). Seven of the 42 patients died, in 2 cases due to complications and in 5 from progression of the disease.
authors.affiliation: Katedra i Klinika Chirurgii Pediatrycznej, Akademia Medyczna we Wrocławiu, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Sawicz-Birkowska
authors.forename: S M
authors.initials: SM
authors.lastname: Bagłaj
authors.forename: A
authors.initials: A
authors.lastname: Balcerska
authors.forename: J
authors.initials: J
authors.lastname: Bohosiewicz
authors.forename: J
authors.initials: J
authors.lastname: Godziński
authors.forename: S
authors.initials: S
authors.lastname: Kantorowicz
authors.forename: P
authors.initials: P
authors.lastname: Kołecki
authors.forename: J
authors.initials: J
authors.lastname: Kowalczyk
authors.forename: D
authors.initials: D
authors.lastname: Perek
authors.forename: R
authors.initials: R
authors.lastname: Chrzan
mesh_terms: D000293:Adolescent; D000708:Anaplasia / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology*; D008297:Male; D011044:Poland / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D009396:Wilms Tumor / Q000401:mortality / Q000473:pathology*