title: Prognostic relevance of Ki-67 antigen expression in 329 cases of oral squamous cell carcinoma.
abstract: Prognostic relevance of Ki-67 staining in oral squamous cell carcinomas was investigated by immunohistochemical expression in 329 cases of squamous cell carcinoma of the oral cavity due to a formamide pretreatment. The growth fraction (Ki-67 labelling index, LI) was correlated to histopathological grading, lymphocytic reaction, stroma/tumour proportion, pattern of invasion, mitotic rate, degree of keratinisation, tumour size, thickness of tumor, depth of invasion, lymph node involvement and five-year survival rate. Highly significant inverse correlation was found between the Ki-67 LI, the stroma/tumour proportion and the degree of keratinisation whereas no correlation could be established between the Ki-67 LI and all the other histological and clinical paramters. Ki-67 staining alone has no prognostic relevance in oral cancer.
authors.affiliation: Gerhard-Domagk-Institut für Pathologie, Universität Münster, Münster, Deutschland. O_Bettendorf@web.de
authors.forename: O
authors.initials: O
authors.lastname: Bettendorf
authors.forename: G
authors.initials: G
authors.lastname: Herrmann
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology*; D002465:Cell Movement; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000276:immunology* / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors
chemical_list: D019394:Ki-67 Antigen