title: Relationships between cognition and structural neuroimaging findings in adults with human immunodeficiency virus type-1.
abstract: Infection of the central nervous system with human immunodeficiency virus type-1 (HIV) is associated with cognitive impairments that range from mild cognitive and motor difficulties to dementia. Structural neuroimaging abnormalities are also common in HIV-infected patients both with and without cognitive disturbances. The most common abnormalities include high signal intensities in the white matter and atrophy. Research over the past 12 years has helped define the relationship between these neuroimaging abnormalities and the manifestation of cognitive disturbance in HIV. In the present paper, we provide a synopsis of these studies and report the current state of the literature. Our review revealed that atrophy of the caudate nucleus is most consistently associated with cognitive impairment in HIV. The current literature does not support a strong relationship between cortical atrophy or white matter abnormalities and cognitive dysfunction in this population, though methodological issues may have influenced the results. Suggestions for study design and new research directions are provided.
authors.affiliation: Department of Psychiatry and Human Behavior, Centers for Behavioral and Preventive Medicine, Brown Medical School, Miriam Hospital, One Hoppin Street, Providence, RI 02903, USA. rpaul@lifespan.org
authors.forename: Robert
authors.initials: R
authors.lastname: Paul
authors.forename: Ronald
authors.initials: R
authors.lastname: Cohen
authors.forename: Bradford
authors.initials: B
authors.lastname: Navia
authors.forename: Karen
authors.initials: K
authors.lastname: Tashima
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D023241:Antiretroviral Therapy, Highly Active; D001284:Atrophy; D002421:Caudate Nucleus / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D003072:Cognition Disorders / Q000473:pathology* / Q000821:virology*; D006801:Humans; D008279:Magnetic Resonance Imaging