[Study of radiation synovectomy using (188)Re-Sulfide in hemophilic arthritis].
OBJECTIVE
To study the effectiveness of radiation synovectomy with (188)Re-sulfide.


METHODS
Twenty rabbit models of joint synovitis were injected intra-articularly with different doses of (188)Re-sulfide from 7.4 to 37.0 MBq. By pathological examination, the effects of (188)Re-sulfide on synovium and cartilage were evaluated. Clinically, 10 joints of 7 cases of hemophilic arthritis with (188)Re-sulfide radiation synovectomy were performed. MRI was taken before and after the synovectomy to evaluate the treatment effects.


RESULTS
In rabbit models, when (188)Re-sulfide dose larger than 14.8 MBq, the radiation effect on synovitis was remarkable, including thinning the thickened synovium and reducing the inflammatory cells. When radio-activity dose increased to 37.0 MBq, pathological damage was noted in cartilage. Clinical trial demonstrated that radiation synovectomy by (188)Re-sulfide could reduce the frequencies of intra-articular hemorrhage. MRI showed that edema and villi reduced.


CONCLUSIONS
Radiation synovectomy using (188)Re-sulfide is effective on synovitis in hemophilic arthritis.
Li
Peiyong
P
Department of Nuclear Medicine of Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China.
Chen
Gang
G
Zhang
Liying
L
Jiang
Xufeng
X
Wang
Xuefeng
X
Sun
Zhengming
Z
Zhang
Huan
H
D000818:Animals; D002712:Chlorides / Q000627:therapeutic use; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D007270:Injections, Intra-Articular; D011817:Rabbits; D012211:Rhenium / Q000627:therapeutic use; D012429:Ruthenium Radioisotopes / Q000627:therapeutic use*; D013440:Sulfides; D013583:Synovial Membrane / Q000528:radiation effects*; D013585:Synovitis / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy*
D002712:Chlorides; D012429:Ruthenium Radioisotopes; D013440:Sulfides; C400124:rhenium sulfide; D012211:Rhenium