[Age features of glycerolipid metabolism in rat liver under short term exposure to thyroxine].
The age specificity of the regulation by thyroid hormones of 1,2-diacylglycerol production in rat liver has been studied. It was found that L-thyroxine-stimulation of the 3-month old rats liver cells resulted in a rapid rise in 1,2-diacylglycerol concentration in hepatocytes and simultaneous degradation of phospholipids. The endogenous phosphatidylcholine and phosphatidylethanolamine are the sources of 1,2-diacylglycerol in a liver. Under the action of hormone liver cells of young rats may product 1,2-diacylglycerol from exogenous 1-acyl, 2-[14C]arachidonyl-phosphatidylethanolamine. Thyroxine had no effect on de novo 1,2-diacylglycerols formation and their release from triacylglycerol. In liver cells of elder rats, 1,2-diacylglycerol and individual phospholipids content are unaffected by hormones.
Kavok
N S
NS
Karazin Kharkov National University, Institute of Biology, Kharkov, Ukraine.
Babenko
N A
NA
D000367:Age Factors; D000818:Animals; D004075:Diglycerides / Q000096:biosynthesis / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000008:administration & dosage / Q000494:pharmacology*
C011439:1,2-diacylglycerol; D004075:Diglycerides; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D013974:Thyroxine