title: Synthesis and profile of SCH351591, a novel PDE4 inhibitor.
abstract: The syntheses and pharmacological profiles of some 2-trifluoromethyl-8-methoxyquinoline-5-carboxamides are described. SCH351591 is a potent selective inhibitor of phosphodiesterase type 4 (PDE4).
authors.affiliation: Schering-Plough Corporation, Galloping Hill Road, Kenilworth, NJ 07033-0530, USA.
authors.forename: Motasim
authors.initials: M
authors.lastname: Billah
authors.forename: Nicola
authors.initials: N
authors.lastname: Cooper
authors.forename: Francis
authors.initials: F
authors.lastname: Cuss
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Davenport
authors.forename: Hazel J
authors.initials: HJ
authors.lastname: Dyke
authors.forename: Robert
authors.initials: R
authors.lastname: Egan
authors.forename: Ashit
authors.initials: A
authors.lastname: Ganguly
authors.forename: Lewis
authors.initials: L
authors.lastname: Gowers
authors.forename: Duncan R
authors.initials: DR
authors.lastname: Hannah
authors.forename: Alan F
authors.initials: AF
authors.lastname: Haughan
authors.forename: Hannah J
authors.initials: HJ
authors.lastname: Kendall
authors.forename: Christopher
authors.initials: C
authors.lastname: Lowe
authors.forename: Michael
authors.initials: M
authors.lastname: Minnicozzi
authors.forename: John G
authors.initials: JG
authors.lastname: Montana
authors.forename: Robert
authors.initials: R
authors.lastname: Naylor
authors.forename: Janet
authors.initials: J
authors.lastname: Oxford
authors.forename: Joanna C
authors.initials: JC
authors.lastname: Peake
authors.forename: John J
authors.initials: JJ
authors.lastname: Piwinski
authors.forename: Karen A
authors.initials: KA
authors.lastname: Runcie
authors.forename: Verity
authors.initials: V
authors.lastname: Sabin
authors.forename: Andrew
authors.initials: A
authors.lastname: Sharpe
authors.forename: Neng-Yang
authors.initials: NY
authors.lastname: Shih
authors.forename: Julie B H
authors.initials: JB
authors.lastname: Warneck
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D019540:Area Under Curve; D003497:Cyclic N-Oxides / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D006168:Guinea Pigs; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D003497:Cyclic N-Oxides; D010726:Phosphodiesterase Inhibitors; D011804:Quinolines; C459379:SCH 351591; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4