title: Orthomolecular oncology: a mechanistic view of intravenous ascorbate's chemotherapeutic activity.
abstract: The effect of vitamin C in cancer has been a subject of great controversy; mainly because of the inconsistent results obtained by oral intakes of ascorbate when used as an anticancer agent. We believe the intravenous application of ascorbate will provide more consistent results in cancer patients since Vitamin C blood levels attained are substantially higher in a range proven cytotoxic to malignant cells. In this article we will present and discuss our proposed mechanism on the chemotherapeutic activity exhibited by ascorbate.
authors.affiliation: University of Puerto Rico, Medical Sciences Campus, School of Public Health, Dept. Human Development, Nutrition Program, RECNAC II Project, GPO Box 365067, San Juan, PR, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: González
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Miranda-Massari
authors.forename: Edna M
authors.initials: EM
authors.lastname: Mora
authors.forename: Ivonne Z
authors.initials: IZ
authors.lastname: Jiménez
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Matos
authors.forename: Hugh D
authors.initials: HD
authors.lastname: Riordan
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Casciari
authors.forename: Neil H
authors.initials: NH
authors.lastname: Riordan
authors.forename: Marielys
authors.initials: M
authors.lastname: Rodríguez
authors.forename: Angelik
authors.initials: A
authors.lastname: Guzmán
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D009369:Neoplasms / Q000188:drug therapy*; D009974:Orthomolecular Therapy
chemical_list: D000975:Antioxidants; D001205:Ascorbic Acid