title: Isolation and identification of dihydrochrysanolide and its 1-epimer from Chrysanthemum coronarium L.
abstract: A new sesquiterpene lactone (1) was isolated with known dihydrochrysanolide derivatives (2 and 3) from the flowers of Chrysanthemum coronarium L., and their structures were identified by spectroscopic data. The stereochemistry of the epimers (1 and 2) was determined from NOESY data and an X-ray crystallographic analysis. The isolated compounds (1-3) were examined for their cytotoxic activity against such human cell lines as A549, PC-3 and HCT-15.
authors.affiliation: Department of Agricultural Chemistry, Gyeongsang National University, Chinju, Korea.
authors.forename: Kyung Dong
authors.initials: KD
authors.lastname: Lee
authors.forename: Min Suk
authors.initials: MS
authors.lastname: Yang
authors.forename: Tae Jung
authors.initials: TJ
authors.lastname: Ha
authors.forename: Ki Min
authors.initials: KM
authors.lastname: Park
authors.forename: Ki Hun
authors.initials: KH
authors.lastname: Park
mesh_terms: D031202:Chrysanthemum / Q000737:chemistry*; D018360:Crystallography, X-Ray; D035263:Flowering Tops / Q000737:chemistry; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: C493683:1-epi-dihydrochrysanolide; D007783:Lactones; D012717:Sesquiterpenes; C493682:dihydrochrysanolide