Fertility results after conservative treatment of advanced stage serous borderline tumour of the ovary.
OBJECTIVE
To assess the fertility of patients treated conservatively for a Stage II or III borderline ovarian tumour.


METHODS
A retrospective study.


METHODS
Gynaecological oncology department in a French anti-cancer centre.


METHODS
Seventeen patients treated with conservative management for a Stage II (n = 6) or III (n = 11) borderline ovarian tumour were followed up. Fifteen patients underwent a unilateral salpingo-oophorectomy (with contralateral cystectomy in six patients), one had unilateral cystectomy and one a bilateral cystectomy. Fourteen patients had non-invasive implants and three had invasive implants.


METHODS
Pregnancy rates and outcome.


RESULTS
Eight pregnancies were observed in seven patients in a median delay of eight months following the surgical procedure. Six pregnancies were observed spontaneously, one occurred after an ovarian stimulation and one after an IVF procedure. None of these patients recurred under the form of invasive ovarian carcinoma on the spared ovary. Two patients (one with a non-invasive disease and one with an invasive one) had recurrence in the form of evolutive invasive implants, but neither woman died.


CONCLUSIONS
Spontaneous pregnancy can occur after conservative treatment of advanced stage borderline tumour of the ovary (with non-invasive implants). Such management, performed in a close follow up of the patients, does not affect the overall survival. Conservative surgery could be proposed in patients with borderline tumour of the ovary and non-invasive peritoneal implants.
Camatte
Sophie
S
Gustave-Roussy Institute, Villejuif, France.
Morice
Philippe
P
Pautier
Patricia
P
Atallah
David
D
Duvillard
Pierre
P
Castaigne
Damienne
D
D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000628:therapy*; D011230:Precancerous Conditions / Q000628:therapy; D011247:Pregnancy / Q000706:statistics & numerical data*; D019736:Prostheses and Implants; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome