GTPase signaling: bridging the GAP between ARF and Rho.
Membrane traffic and actin cytoskeleton dynamics are intimately linked, and GTPases of the Rho and ARF families may work together to regulate both. Recent studies have identified a family of GTPase activating proteins (GAPs) that contain both ARF-GAP and Rho-GAP domains, providing the first direct link between these two signaling pathways.
Santy
Lorraine C
LC
Department of Cell Biology, University of Virginia, Health Sciences Center, P.O. Box 800732, Charlottesville, Virginia 22908-0732, USA.
Casanova
James E
JE
D020727:ADP-Ribosylation Factors / Q000378:metabolism*; D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D020690:GTPase-Activating Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
C446513:ARAP1 protein, human; C446512:ARAP3 protein, human; D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D020690:GTPase-Activating Proteins; D020727:ADP-Ribosylation Factors; D020741:rho GTP-Binding Proteins