New metabolites from sponge-derived fungi Curvularia lunata and Cladosporium herbarum.
The fungus Curvularia lunata, isolated from the marine sponge Niphates olemda, yielded the new 1,3,8-trihydroxy-6-methoxyanthraquinone, which we named lunatin (1), the known modified bisanthraquinone cytoskyrin A (2), and the known plant hormone (+)-abscisic acid (3). Both anthraquinones were found to be active against Bacillus subtilis, Staphylococcus aureus, and Escherichia coli. Two strains of the fungus Cladosporium herbarum, isolated from the sponges Aplysina aerophoba and Callyspongia aerizusa, respectively, yielded two new alpha-pyrones, herbarin A (4) and herbarin B (5), the known compound citreoviridin A (6), and the new phthalide herbaric acid (7). All structures were unambiguously established by 1D and 2D NMR and MS data.
Jadulco
Raquel
R
Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsststrasse 1, Geb.26.23, D-40225 Düsseldorf, Germany.
Brauers
Gernot
G
Edrada
Ru Angelie
RA
Ebel
Rainer
R
Wray
Victor
V
Sudarsono
Sudarsono
S
Proksch
Peter
P
D000040:Abscisic Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002855:Chromatography, Thin Layer; D004926:Escherichia coli / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005658:Fungi / Q000737:chemistry*; D007214:Indonesia; D008522:Mediterranean Sea; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera; D018411:Spodoptera / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
C460121:1,3,8-trihydroxy-6-methoxyanthraquinone; D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; C419462:cytoskyrin A; D000040:Abscisic Acid