title: Autoantibodies to amphiphysin I and amphiphysin II in a patient with sensory-motor neuropathy.
abstract: A proportion of patients with peripheral neuropathies has circulating autoantibodies directed against neural antigens. In some cases, autoantibodies may play a pathogenic role. We studied a patient with a progressive sensory-motor axonal neuropathy of unknown etiology, looking for circulating autoantibodies against neural antigens and we showed that the patient's serum contained anti-amphiphysin I (AMP I) and amphiphysin II (AMP II) autoantibodies. A sural nerve biopsy revealed an axonal neuropathy. Indirect immunofluorescence experiments with the patient's serum showed a staining of rat axons due to alpha-AMP I autoantibodies and a specific labelling of cytoplasm and Schmidt-Lanterman incisures of Schwann cells due to alpha-AMP II autoantibodies. In conclusion we identified a patient affected by a sensory-motor neuropathy with autoantibodies against both AMP I and AMP II.
authors.affiliation: Unit for Metabolic Diseases, IRCCS H.S. Raffaele, Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Perego
authors.forename: S C
authors.initials: SC
authors.lastname: Previtali
authors.forename: R
authors.initials: R
authors.lastname: Nemni
authors.forename: R
authors.initials: R
authors.lastname: Longhi
authors.forename: O
authors.initials: O
authors.lastname: Carandente
authors.forename: A
authors.initials: A
authors.lastname: Saibene
authors.forename: R
authors.initials: R
authors.lastname: Sciolla
authors.forename: A
authors.initials: A
authors.lastname: Villa
authors.forename: P
authors.initials: P
authors.lastname: Gai
authors.forename: C
authors.initials: C
authors.lastname: Panzeri
authors.forename: G
authors.initials: G
authors.lastname: Dell'Antonio
authors.forename: A
authors.initials: A
authors.lastname: Quattrini
authors.forename: F
authors.initials: F
authors.lastname: Folli
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D015153:Blotting, Western; D005455:Fluorescent Antibody Technique; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009046:Motor Neurons / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009431:Neural Conduction / Q000502:physiology
chemical_list: D001323:Autoantibodies; D009419:Nerve Tissue Proteins; C075637:amphiphysin