title: [Daphnia magna for studies of cholinergic preparations].
abstract: Published data and original experimental results are summarized to justify biochemically the use of Daphnia magna Straus as an additional or alternative test object for the study of cholinotropic substances. The data of radioligand analysis provide direct evidence that the organism of Daphnia contains M-cholinoreceptors identical (with respect to pharmacodynamic parameters) to those in the human and animal organism.
authors.affiliation: Institute of Toxicology, Ministry of Public Health of the Russian Federation, ul. Bekhtereva 1, St. Petersburg, 193019 Russia.
authors.forename: N P
authors.initials: NP
authors.lastname: Podosinovikova
authors.forename: A B
authors.initials: AB
authors.lastname: Kosmachev
authors.forename: V D
authors.initials: VD
authors.lastname: Tonkopiĭ
authors.forename: A O
authors.initials: AO
authors.lastname: Zagrebin
authors.forename: E A
authors.initials: EA
authors.lastname: Evdokimova
authors.forename: A M
authors.initials: AM
authors.lastname: Malov
authors.forename: V V
authors.initials: VV
authors.lastname: Petrov
authors.forename: V B
authors.initials: VB
authors.lastname: Dolgo-Saburov
mesh_terms: D000818:Animals; D002415:Cats; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D003621:Daphnia / Q000378:metabolism*; D004285:Dogs; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D011869:Radioligand Assay; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism; D013045:Species Specificity
chemical_list: D018680:Cholinergic Antagonists; D011976:Receptors, Muscarinic