Regulation of membrane type-matrix metalloproteinases.
Pericellular proteolysis is a hallmark of tumor cell metastasis. The membrane type (MT)-matrix metalloproteinases (MMPs) constitute a distinctive group of membrane-bound MMPs that are central mediators of surface proteolytic events that regulate tumor cell motility, metastasis and angiogenesis. As membrane-tethered proteases, the MT-MMPs exhibit unique regulatory mechanisms and interactions with metalloproteinase inhibitors and other relevant molecules. This review will focus on new emerging information on the mechanisms that regulate MT-MMP processing, activity and inhibition, and their significance for enzyme function in the tumor microenvironment.
Hernandez-Barrantes
Sonia
S
Department of Pathology, Wayne State University, Detroit, MI 48201, USA.
Bernardo
Margarida
M
Toth
Marta
M
Fridman
Rafael
R
D002462:Cell Membrane / Q000201:enzymology; D004789:Enzyme Activation; D004792:Enzyme Precursors / Q000378:metabolism; D006801:Humans; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology*
D004792:Enzyme Precursors; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases