In vitro characterization and in vivo testosterone suppression of 6-month release poly(D,L-lactide) leuprolide microspheres.
Woo
Byung Ho
BH
Faculty of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536, USA.
Na
Kyu-Heum
KH
Dani
Bhas A
BA
Jiang
Ge
G
Thanoo
B C
BC
DeLuca
Patrick P
PP
D000818:Animals; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000008:administration & dosage / Q000493:pharmacokinetics; D016729:Leuprolide / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D008863:Microspheres; D011091:Polyesters / Q000008:administration & dosage* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000097:blood*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D013739:Testosterone; C033616:poly(lactide); D016729:Leuprolide