title: In vivo effect of the lipido-sterolic extract of Serenoa repens (Permixon) on mast cell accumulation and glandular epithelium trophism in the rat prostate.
abstract: The Serenoa repens lipido-sterolic extract (SRLSE, Permixon, Pierre Fabre Medicament, Castres, France) is used to treat benign prostate hyperplasia. We studied the in vivo effect of SRLSE on mast cell accumulation and the histological characteristics of the rat ventral prostate. Adult Wistar rats received either tocopherol or SRLSE (50 and 100 mg/kg body weight, respectively) every second day for 90 days. Histological features were studied in hematoxylin-eosin stained tissue sections while mean mast cell numbers were determined in Giemsa-stained sections. The central region of the ventral prostate in treated animals showed significant changes with acinar epithelium becoming flat or low cuboidal. In the same region, mean mast cell number per optical field in the control, low-dose and high-dose groups were, respectively, 4.7+/-0.7, 3.4+/-1.0 and 2.4+/-0.6, showing a dose-dependent, statistically significant decrease. Administering SRLSE significantly reduces mast cell accumulation and provokes epithelium atrophy within the central area of the rat ventral prostate. These phenomena may participate in the clinical activity of the drug.
authors.affiliation: Department of Urology, Athens Medical School, Greece. dmp@otenet.gr
authors.forename: Dionisios
authors.initials: D
authors.lastname: Mitropoulos
authors.forename: Aspasia
authors.initials: A
authors.lastname: Kyroudi
authors.forename: Anastasios
authors.initials: A
authors.lastname: Zervas
authors.forename: Stefanos
authors.initials: S
authors.lastname: Papadoukakis
authors.forename: Aris
authors.initials: A
authors.lastname: Giannopoulos
authors.forename: Christos
authors.initials: C
authors.lastname: Kittas
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Karayannacos
mesh_terms: D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D011467:Prostate / Q000187:drug effects* / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012680:Sensitivity and Specificity; D028024:Serenoa; D024505:Tocopherols / Q000494:pharmacology*
chemical_list: D000726:Androgen Antagonists; D010936:Plant Extracts; C040972:saw palmetto extract; D024505:Tocopherols