Expression of survivin in CIN and invasive squamous cell carcinoma of uterine cervix.
BACKGROUND
Survivin is a novel member of the inhibitors of apotosis proteins (IAP). To evaluate the possible role of survivin in tumorigenesis of CIN (cervical intraepithelial neoplasia) and invasive squamous cervical carcinoma of the uterine cervix (SCC), the expression of survivin was studied.


RESULTS
In 41 CIN and SCC tissues, the expression of survivin, Fas-ligand, Fas and bcl-2 was studied by immunohistochemistry. Survivin expression tended to increase along with tumor progression; low-grade squamous intra-epithelial lesions (HSIL, CIN I), 66.7%, high-grade squamous epithelial lesions (HSIL, CIN II and III), 87.5% and SCC, 100% with a statistical significance (p<0.019). Alteration of Fas-ligand, Fas and bcl-2 expression was detected in 12.5%-25% of HSIL and in 7.7%-30.8% of SCC but no abnormal expression was found in LSIL.


CONCLUSIONS
Survivin expression seems to be more closely related to the progression of CIN and SCC compared to Fas-ligand, Fas and bcl-2.
Kim
Han-Seong
HS
Department of Anatomic Pathology, Inje University Ilsan Paik Hospital, Koyang City, Kyunggi-do, Republic of Korea.
Shiraki
Katsuya
K
Park
Sung-Hye
SH
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002868:Chromosomal Proteins, Non-Histone / Q000096:biosynthesis* / Q000502:physiology; D053222:Fas Ligand Protein; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000502:physiology; D008869:Microtubule-Associated Proteins; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis / Q000502:physiology; D000077022:Survivin; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology; D019014:fas Receptor / Q000096:biosynthesis / Q000502:physiology; D002578:Uterine Cervical Dysplasia / Q000378:metabolism*
C107489:BIRC5 protein, human; D002868:Chromosomal Proteins, Non-Histone; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D051034:Inhibitor of Apoptosis Proteins; D008562:Membrane Glycoproteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D000077022:Survivin; D019014:fas Receptor