title: Treatment of Scedosporium apiospermum brain abscesses with posaconazole.
abstract: A 41-year-old man with acute lymphoblastic leukemia developed multiple Scedosporium apiospermum brain abscesses. The infection progressed despite neurosurgical drainage and treatment with itraconazole, amphotericin B, and ketoconazole, but the brain abscesses completely resolved after treatment with posaconazole alone.
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA, 90095, USA.
authors.forename: Ingo K
authors.initials: IK
authors.lastname: Mellinghoff
authors.forename: Drew J
authors.initials: DJ
authors.lastname: Winston
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Mukwaya
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Schiller
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001922:Brain Abscess / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008271:Mycetoma / Q000188:drug therapy*; D021681:Scedosporium / Q000187:drug effects; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole