Translocation of the HMGI-C ( HMGA2) gene in a benign mesenchymoma (chondrolipoangioma).
Mesenchymomas are neoplasms in which there are at least two types of differentiated cells of mesenchymal derivation other than fibrous tissue. Chondrolipoangioma is a rare type of mesenchymoma composed predominantly of cartilage and adipose tissue with vascular elements and myxoid tissue present in lesser proportions. Cytogenetic analysis was performed on a case of chondrolipoangioma and revealed a t(12;15) (q13;q26) as the sole chromosome abnormality in 40 metaphases analyzed. However, using fluorescence in situ hybridization (FISH) analysis, a complex rearrangement was found involving chromosomes 2, 12, and 15, with a cryptic rearrangement of the gene ( HMGI-C; HMGA2) coding for high-mobility group I protein. This finding suggests a role for the HMGI-C gene also in the pathogenesis of this uncommon benign tumor type, in addition to its well-established role in the pathogenesis of common benign tumors such as lipomas, uterine leiomyomas, pulmonary chondroid hamartomas, and endometrial polyps.
Van Dorpe
Jo
J
Department of Pathology, University Hospital St-Raphaël, Leuven Catholic University, Minderbroederstraat 12, 3000 Leuven, Belgium.
Dal Cin
Paola
P
Weremowicz
Stanislawa
S
Van Leuven
Fred
F
de Wever
Ivo
I
Van den Berghe
Herman
H
Fletcher
Christopher D M
CD
Sciot
Raf
R
D000199:Actins / Q000032:analysis; D001706:Biopsy; D002881:Chromosomes, Human, Pair 12; D002884:Chromosomes, Human, Pair 15; D003893:Desmin / Q000032:analysis; D025743:HMGA2 Protein / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008637:Mesenchymoma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000235:genetics* / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis; D014178:Translocation, Genetic
D000199:Actins; D003893:Desmin; D025743:HMGA2 Protein; D009418:S100 Proteins