title: Diabetic nephropathy in KK and KK-Ay mice.
abstract: KK mice and KK-Ay mice were examined for age related changes in blood and urinary biophysiological parameters. Blood hemoglobin A1c levels were significantly higher in KK-Ay and KK mice as compared to non-diabetic ddY mice. In both diabetic mice, especially KK-Ay mice, plasma insulin levels markedly increased at 2 to 4 months of age, and the urinary glucose and microalbumin levels and albumin-to-creatinine ratios increased dependent on age. Plasma thrombomodulin levels significantly increased at 2 to 4 months of age in both KK and KK-Ay mice. Mild enlargement of mesangial matrix and segmental proliferative glomerular nephritis were revealed in KK and KK-Ay mice, respectively, at 4 months of age. KK-Ay mice with insulin resistance and high urine mAlb level might be useful as models for the early stage of diabetic nephropathy.
authors.affiliation: Department of Pharmacology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8555, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Okazaki
authors.forename: Yukako
authors.initials: Y
authors.lastname: Saito
authors.forename: Yuko
authors.initials: Y
authors.lastname: Udaka
authors.forename: Mine
authors.initials: M
authors.lastname: Maruyama
authors.forename: Hidetomo
authors.initials: H
authors.lastname: Murakami
authors.forename: Sumiko
authors.initials: S
authors.lastname: Ota
authors.forename: Takuya
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Katsuji
authors.initials: K
authors.lastname: Oguchi
mesh_terms: D000419:Albuminuria / Q000235:genetics; D000818:Animals; D003928:Diabetic Nephropathies / Q000097:blood / Q000235:genetics* / Q000473:pathology / Q000652:urine; D004195:Disease Models, Animal; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D008817:Mice, Mutant Strains / Q000235:genetics*; D013045:Species Specificity; D018180:Thrombomodulin / Q000097:blood
chemical_list: D006442:Glycated Hemoglobin; D007328:Insulin; D018180:Thrombomodulin