title: Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.
abstract: We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.
authors.affiliation: Tularik Inc., Genomics Division, 266 Pulaski Road, Greenlawn, New York, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Yue
authors.initials: Y
authors.lastname: Peng
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Austin
authors.forename: Winfried G
authors.initials: WG
authors.lastname: van Eyndhoven
authors.forename: Ken C Q
authors.initials: KC
authors.lastname: Nguyen
authors.forename: Tim
authors.initials: T
authors.lastname: Gabriele
authors.forename: Mila E
authors.initials: ME
authors.lastname: McCurrach
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Marks
authors.forename: Timothy
authors.initials: T
authors.lastname: Hoey
authors.forename: Scott W
authors.initials: SW
authors.lastname: Lowe
authors.forename: Scott
authors.initials: S
authors.lastname: Powers
mesh_terms: D017209:Apoptosis / Q000235:genetics; D001943:Breast Neoplasms / Q000209:etiology / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005260:Female; D005784:Gene Amplification; D006801:Humans; D009363:Neoplasm Proteins; D009857:Oncogenes / Q000235:genetics; D010749:Phosphoprotein Phosphatases / Q000235:genetics*; D000071636:Protein Phosphatase 2C
chemical_list: D009363:Neoplasm Proteins; C000607458:PPM1D protein, human; D010749:Phosphoprotein Phosphatases; D000071636:Protein Phosphatase 2C