title: Resistance of Helicobacter pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime.
abstract: The resistance of Helicobacter pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime was tested in 138 isolates, including 28 from treatment failures. No resistance to tetracycline was detected. Resistance to amoxicillin was found in one isolate (MIC = 1.5 mg/L) from an untreated patient, and resistance to cefixime in two isolates from each group (P = 0.18). Resistance to metronidazole and clarithromycin was much higher in the isolates from treated than from untreated patients: 60.7% and 38.2% for metronidazole (MIC >or= 8 mg/L) (P = 0.03); 46.4% and 8.2% for clarithromycin (MIC >or= 2 mg/L) (P < 0.001). Therapeutic outcome would benefit from susceptibility testing, especially after treatment failure.
authors.affiliation: Microbiology Laboratories, Helicobacter pylori Research Institute, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel. zsamra@clalit.org.il
authors.forename: Zmira
authors.initials: Z
authors.lastname: Samra
authors.forename: Haim
authors.initials: H
authors.lastname: Shmuely
authors.forename: Yaron
authors.initials: Y
authors.lastname: Niv
authors.forename: Gabriel
authors.initials: G
authors.lastname: Dinari
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Passaro
authors.forename: Alex
authors.initials: A
authors.lastname: Geler
authors.forename: Eyal
authors.initials: E
authors.lastname: Gal
authors.forename: Michal
authors.initials: M
authors.lastname: Fishman
authors.forename: Jacklin
authors.initials: J
authors.lastname: Bachor
authors.forename: Jacob
authors.initials: J
authors.lastname: Yahav
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology*; D020682:Cefixime / Q000494:pharmacology*; D016009:Chi-Square Distribution; D017291:Clarithromycin / Q000494:pharmacology*; D016001:Confidence Intervals; D024901:Drug Resistance, Multiple, Bacterial / Q000502:physiology; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D008875:Middle Aged; D013752:Tetracycline / Q000494:pharmacology*
chemical_list: D008795:Metronidazole; D000658:Amoxicillin; D020682:Cefixime; D013752:Tetracycline; D017291:Clarithromycin