Scleritis as the initial clinical manifestation of graft-versus-host disease after allogenic bone marrow transplantation.
OBJECTIVE
To describe a case of scleritis with choroidal detachment as the initial clinical manifestation of graft-versus-host disease after allogenic bone marrow transplantation.


METHODS
Interventional case report.


METHODS
Review of clinical records.


RESULTS
A 50-year-old man developed symptoms of mild dry eye syndrome 20 days after receiving a one-antigen-mismatched allogenic bone marrow transplant. Five days later, he developed orbital pain, moderate visual loss, and a sterile orbital abscess on the left side. The orbital inflammatory collection was drained, and symptoms improved. On day 41 after bone marrow transplantation, the patient developed severe ocular pain and scleral thickening with secondary choroidal detachment and glaucoma in the right eye. The patient had no systemic signs of graft-versus-host disease at this time. The ocular symptoms and signs responded remarkably well to intravenous corticosteroids. Six months after bone marrow transplantation, while receiving low-dose oral methylprednisolone, the patient developed a skin rash. A biopsy of the involved skin confirmed the diagnosis of graft-versus-host disease.


CONCLUSIONS
Scleritis can be the initial clinical manifestation of graft-versus-host disease after allogenic bone marrow transplantation.
Kim
Rosa Y
RY
Vitreoretinal Consultants, Houston, Texas, USA.
Anderlini
Paolo
P
Naderi
Aresu A
AA
Rivera
Pettion
P
Ahmadi
M Amir
MA
Esmaeli
Bita
B
D000086:Acetazolamide / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D000068438:Brimonidine Tartrate; D015862:Choroid Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D004359:Drug Therapy, Combination; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000628:therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D011810:Quinoxalines / Q000627:therapeutic use; D015423:Scleritis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014184:Transplantation, Homologous
D011810:Quinoxalines; D000068438:Brimonidine Tartrate; D000086:Acetazolamide; D008775:Methylprednisolone