title: Catastrophic visceral involvement secondary to de novo systemic vasculitis in a renal transplant recipient.
abstract: De novo systemic vasculitis after renal transplant is a rare complication. We report a patient who developed rapid, catastrophic necrotizing vasculitis of the gastrointestinal tract 11 months after renal transplant. A 60-year-old man was admitted for persistent pain in the right abdomen and mild intestinal hemorrhage. After some days the patient presented partial intestinal occlusion, severe hypoproteinemia and acute renal insufficiency. The patient was urgently operated with resection of a tract of the jejunum where there was a venous infarct. Laboratory tests were not significant and the search for hepatitis B, C viruses and ANCA was negative. After some days of irrepressible intestinal hemorrhage, total gastrectomy, splenectomy and resection of the duodenum and pancreas were performed. Histological pictures showed vascular lesions pathognomonic of systemic polyarteritis nodosa (PAN). After thirty days the patient died. The autopsy confirmed atypical systemic PAN with involvement of the pulmonary arteries besides the gastrointestinal tract and pancreas. Gastrointestinal (GI) complications are not frequent in renal transplant recipients, but 30% of patients with such lesions die as a direct consequence of visceral vascular damage. To the best of our knowledge, de novo PAN has been reported as the cause of catastrophic gastrointestinal involvement in only one renal transplant recipient. This case therefore raises the number of reports of PAN in kidney transplantation recipients who had no history of underlying connective tissue disease.
authors.affiliation: Division of Nephrology, Sant'Anna Hospital, Ferrara, Italy. bep@unife.it
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Bedani
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bergami
authors.forename: Giovanni
authors.initials: G
authors.lastname: Mugnani
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Cavazzini
authors.forename: Giordano
authors.initials: G
authors.lastname: Stabellini
authors.forename: Paolo
authors.initials: P
authors.lastname: Gilli
mesh_terms: D017809:Fatal Outcome; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000601:surgery; D006801:Humans; D007165:Immunosuppression Therapy; D007415:Intestinal Obstruction / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008638:Mesenteric Arteries / Q000473:pathology; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000209:etiology* / Q000473:pathology