Synthesis and profile of SCH351591, a novel PDE4 inhibitor.
The syntheses and pharmacological profiles of some 2-trifluoromethyl-8-methoxyquinoline-5-carboxamides are described. SCH351591 is a potent selective inhibitor of phosphodiesterase type 4 (PDE4).
Billah
Motasim
M
Schering-Plough Corporation, Galloping Hill Road, Kenilworth, NJ 07033-0530, USA.
Cooper
Nicola
N
Cuss
Francis
F
Davenport
Richard J
RJ
Dyke
Hazel J
HJ
Egan
Robert
R
Ganguly
Ashit
A
Gowers
Lewis
L
Hannah
Duncan R
DR
Haughan
Alan F
AF
Kendall
Hannah J
HJ
Lowe
Christopher
C
Minnicozzi
Michael
M
Montana
John G
JG
Naylor
Robert
R
Oxford
Janet
J
Peake
Joanna C
JC
Piwinski
John J
JJ
Runcie
Karen A
KA
Sabin
Verity
V
Sharpe
Andrew
A
Shih
Neng-Yang
NY
Warneck
Julie B H
JB
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D019540:Area Under Curve; D003497:Cyclic N-Oxides / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D006168:Guinea Pigs; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*
D003497:Cyclic N-Oxides; D010726:Phosphodiesterase Inhibitors; D011804:Quinolines; C459379:SCH 351591; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4