title: Impact of prior nicotine replacement therapy on smoking cessation efficacy.
abstract: OBJECTIVE
  To examine previous use of nicotine replacement therapy (NRT) on the smoking-cessation efficacy of bupropion sustained release (SR).
  
  
  METHODS
  Secondary analysis of a parallel-group, randomized, double-blind, placebo-controlled study. Smokers who had, based on self-report, no previous history of NRT (N = 453) or who had used NRT at least once (N = 440) were randomized to receive placebo, bupropion SR, nicotine transdermal system (NTS), or a combination of bupropion SR and NTS.
  
  
  RESULTS
  Bupropion SR showed similar efficacy in participants with or without previous use of NRT.
  
  
  CONCLUSIONS
  Bupropion SR is effective in promoting smoking abstinence regardless of prior NRT use.
authors.affiliation: GlaxoSmithKline, Research Triangle Park, NC 27709, USA. mjd15743@GlaxoWellcome.com
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Durcan
authors.forename: Jonathan
authors.initials: J
authors.lastname: White
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Jorenby
authors.forename: Michael C
authors.initials: MC
authors.lastname: Fiore
authors.forename: Stephen I
authors.initials: SI
authors.lastname: Rennard
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Leischow
authors.forename: Mitchell A
authors.initials: MA
authors.lastname: Nides
authors.forename: John A
authors.initials: JA
authors.lastname: Ascher
authors.forename: J Andrew
authors.initials: JA
authors.lastname: Johnston
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage / Q000627:therapeutic use*; D016540:Smoking Cessation / Q000379:methods*; D014029:Tobacco Use Disorder / Q000188:drug therapy*; D016896:Treatment Outcome; D014481:United States
chemical_list: D018687:Antidepressive Agents, Second-Generation; D009538:Nicotine