Microbiological profile of teicoplanin.
The in-vitro antibacterial activity of teicoplanin, a new glycopeptide antibiotic, previously named teichomycin A2, was tested against 258 gram-positive anaerobic bacterial strains, recently clinically isolated, by measuring the minimum inhibitory concentrations. Comparisons were made with other drugs, clindamycin, rifampicin, netilmicin, enoxacin, vancomycin, widely utilized for the treatment of bacterial infections. Teicoplanin was very active against the tested species and showed the highest activity against all the tested strains, with a geometric mean of MICs, a MIC 50 and MIC 90 of 0.125, 0.12 and 0.5 microg/ml, respectively.
Covelli
I
I
Department of Cellular and Molecular Biology and Pathology, II Medical School, University of Naples, Italy.
Nani
E
E
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D008826:Microbial Sensitivity Tests; D017334:Teicoplanin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D017334:Teicoplanin