Application of disposable plastic microfluidic device arrays with customized chemistries to multiplexed biochemical assays.
Plastic microfluidic array platforms and synergistic multiplexed assay chemistries are under development for a variety of applications, including assays of gene expression, proteomics, genotyping, DNA sequencing and fragment analysis, sample preparation and high-throughput pharmaceutical discovery. The low production costs of plastic substrates makes possible economical single-use device arrays, eliminating cleaning and sample-to-sample carryover contamination. Hundreds of microchannels and reservoirs are readily included on a single microtitre-plate-size substrate, enabling the manufacture of highly parallel fluidic array systems to increase throughput and speed.
Ricco
A J
AJ
ACLARA BioSciences, Inc., 1288 Pear Avenue, Mountain View, CA 94043, U.S.A. aricco@aclara.com
Boone
T D
TD
Fan
Z H
ZH
Gibbons
I
I
Matray
T
T
Singh
S
S
Tan
H
H
Tian
T
T
Williams
S J
SJ
D004353:Drug Evaluation, Preclinical / Q000295:instrumentation; D020869:Gene Expression Profiling / Q000295:instrumentation; D006801:Humans; D008832:Microchemistry / Q000295:instrumentation*; D008904:Miniaturization; D010969:Plastics; D017422:Sequence Analysis, DNA / Q000295:instrumentation
D010969:Plastics