[Studies on synthesis and analgesic activities of bifentanyl derivatives].
In order to look for potent analgesic compounds and to study the relationships between structures and activities, twenty bifentanyl derivatives were synthesized and their analgesic activities were tested. The structures of the compounds were confirmed by spectral analysis and elemental analysis. Compounds IIa and IIb showed strong analgesic activities in preliminary pharmacological test. Further pharmacological examinations are in progress.
Ding
P
P
School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083.
Li
R
R
Cai
M
M
D000701:Analgesics, Opioid / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000701:Analgesics, Opioid; D005283:Fentanyl