title: Propylene glycol toxicity associated with lorazepam infusion in a patient receiving continuous veno-venous hemofiltration with dialysis.
abstract: We report a case of toxicity from the drug solvent propylene glycol resulting from prolonged, large-dose lorazepam infusion. The case is unusual in that toxicity developed during continuous veno-venous hemofiltration with dialysis, a renal replacement therapy that should been have been effective at eliminating the chemical and its metabolites.
authors.affiliation: Section of Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA. Ali.H.Al-Khafaji@Hitchcock.org
authors.forename: Ali H
authors.initials: AH
authors.lastname: Al-Khafaji
authors.forename: William E
authors.initials: WE
authors.lastname: Dewhirst
authors.forename: Harold L
authors.initials: HL
authors.lastname: Manning
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D018757:GABA Modulators / Q000009:adverse effects* / Q000097:blood; D006440:Hemofiltration / Q000009:adverse effects*; D006801:Humans; D016030:Kidney Transplantation; D008140:Lorazepam / Q000009:adverse effects* / Q000097:blood; D008297:Male; D008970:Molecular Weight; D009102:Multiple Organ Failure / Q000209:etiology; D010195:Pancreatitis / Q000139:chemically induced / Q000473:pathology; D019946:Propylene Glycol / Q000009:adverse effects* / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects*; D012997:Solvents
chemical_list: D018757:GABA Modulators; D012997:Solvents; D019946:Propylene Glycol; D008140:Lorazepam