Regulation of T cell apoptosis during the immune response.
Apoptosis of T-lymphocytes is a fundamental process regulating antigen receptor repertoire selection during T cell maturation and homeostasis of the immune system. It also plays a key role in elimination of autoreactive lymphocytes. Resting mature T cells are activated by antigen to elicit an appropriate immune response. In contrast, preactivated T cells undergo activation-induced cell death (AICD) in response to TCR triggering alone. Thus, death by apoptosis is essential for function, growth and differentiation of T-lymphocytes. This review focuses on apoptosis mechanisms involved in T cell development and during the course of an immune response.
Baumann
Sven
S
Tumor Immunology Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Krueger
Andreas
A
Kirchhoff
Sabine
S
Krammer
Peter H
PH
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D018106:CD28 Antigens / Q000378:metabolism; D017637:Clonal Deletion / Q000276:immunology; D006801:Humans; D007109:Immunity; D007156:Immunologic Memory; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D019014:fas Receptor / Q000276:immunology
D018106:CD28 Antigens; D019014:fas Receptor