title: [Sero-epidemiological study of the hepatitis epidemic in Mitrovica in the aftermath of the war in Kosovo (1999)].
abstract: In July 1999, after the return of the Kosovar refugees to their country, an outbreak of acute hepatitis A (HAV) and E (HEV) occurred. Epidemic hepatitis and diarrhoea are closely monitored communicable diseases which had been singled out as priorities by the health authorities of the former Republic of Yougoslavia. Several field surveys were undertaken: description of reported cases, serological study of clinical patients, study of anti-HAV seroprevalence in a school and a case control study to assess risk factors. The analysis of the reports indicates an epidemic peak at the end of September, 2 or 3 weeks after the start of the new school year, with an increase of cases relative to the age of the children in school. In a serologic study of 104 samples, we found an anti-HAV IgM positivity in 88% of the cases. Children were more likely to be positive when compared to teenagers and adults; likewise, consumers of well-water as versus those drinking network water (p = 0.03). The study of seroprevalence showed that transmission had taken place within the school. The case control study, in spite of its imperfections, indicated that consumption of water melon, the only fruit cultivated locally, is a factor which facilitates the HAV transmission. Circulation of the hepatitis E virus was confirmed for 4 sick persons (including 2 co-infected HAV-HEV) and in 4 persons without clinical symptoms. These results show the permanent risk of faeco-oral infections in this area and the need to develop a relevant prevention policy.
authors.affiliation: Institut de santé publique de Mitrovica, Kosovo.
authors.forename: J L
authors.initials: JL
authors.lastname: Rey
authors.forename: Q
authors.initials: Q
authors.lastname: Ramadani
authors.forename: J L
authors.initials: JL
authors.lastname: Soarès
authors.forename: E
authors.initials: E
authors.lastname: Nicand
authors.forename: D
authors.initials: D
authors.lastname: Ibrahime
authors.forename: E
authors.initials: E
authors.lastname: Preteni
authors.forename: Y
authors.initials: Y
authors.lastname: Buisson
authors.forename: R
authors.initials: R
authors.lastname: Teyssou
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005638:Fruit; D006506:Hepatitis A / Q000175:diagnosis / Q000453:epidemiology* / Q000635:transmission; D030041:Hepatitis A virus / Q000276:immunology; D006508:Hepatitis Antibodies / Q000097:blood; D016751:Hepatitis E / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D008297:Male; D008875:Middle Aged; D012036:Refugees; D012574:Schools; D016036:Seroepidemiologic Studies; D012698:Serologic Tests; D015022:Yugoslavia / Q000453:epidemiology
chemical_list: D006508:Hepatitis Antibodies; D007075:Immunoglobulin M