The effect of (-)-hydroxycitrate on energy intake and satiety in overweight humans.
OBJECTIVE
Assessment of the effects of 2 weeks of daily administration of HCA on energy intake and satiety in overweight men and women.


METHODS
A 6-week randomized placebo-controlled single-blinded cross-over trial.


METHODS
consumed three times daily for 2 weeks 100 ml tomato juice (placebo) and, separated by a 2 week wash-out period, 100 ml tomato juice with 300 mg HCA.Subjects: Twelve males and 12 females (body mass index 27.5+/-2.0 kg/m(2); age 37+/-10 y).


METHODS
After 2 weeks, 24 h energy intake (EI), appetite profile, hedonics, mood and possible change in dietary restraint were assessed in the laboratory restaurant. Prevention of degradation and bio-availability was documented.


RESULTS
Twenty-four-hour EI was decreased by 15-30% (P<0.05) with HCA treatment compared to placebo, without changes in the appetite profile, dietary restraint, mood, taste perception and hedonics, while body weight tended to decrease (P=0.1).


CONCLUSIONS
HCA treatment reduced 24 h EI in humans while satiety was sustained.
Westerterp-Plantenga
M S
MS
Department of Human Biology, University of Maastricht, Maastricht, The Netherlands. M.Westerterp@HB.Unimaas.nl
Kovacs
E M R
EM
D000328:Adult; D000339:Affect / Q000187:drug effects; D001066:Appetite / Q000187:drug effects; D002951:Citrates / Q000008:administration & dosage* / Q000627:therapeutic use; D002149:Energy Intake / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012527:Satiation / Q000187:drug effects*; D013649:Taste / Q000187:drug effects
D002951:Citrates; D010919:Placebos; C007999:hydroxycitric acid