[The influence of isosorbide mononitrate on skin blood flow in patients with Raynaud's syndrome].
The influence of isosorbide mononitrate on skin blood flow in the pulp of finger by means of laser-Doppler flowmetry was evaluated in 19 women with Raynaud's syndrome. Skin blood flow changes were measured after cooling the hand. Isosorbide mononitrate decreased the influence of cooling on skin blood flow in the pulp of finger. This finding supports the theory that endothelial dysfunction is one of the reasons of Raynaud's syndrome. We suppose that application of isosorbide mononitrate should be useful in prevention and the treatment of Raynaud's phenomenon attacks.
Gross
Robert
R
Kliniki Geriatrii Centrum Medycznego Kształcenia Podyplomowego w Warszawie.
Galus
Krzysztof
K
Zajac
Stanisław
S
Jedrasik
Maciej
M
D005260:Female; D005385:Fingers / Q000098:blood supply; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000031:analogs & derivatives; D017078:Laser-Doppler Flowmetry; D008297:Male; D011928:Raynaud Disease / Q000188:drug therapy* / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply*; D014665:Vasodilator Agents / Q000008:administration & dosage*
D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate