Effect of IL-18 on IL-1beta and sIL-1RII production by human neutrophils.
In the present study we investigated the effect of interleukin 18 (IL-18) on the production of IL-1beta and soluble IL-1 receptor II (sIL-1RII) by human neutrophils. The results obtained indicate that recombinant human IL-18 (rhIL-18) induces IL-1beta and, to a lesser extent, sIL-1RII production by human neutrophil isolated from peripheral blood. However, this effect was less important than lipopolysaccharide (LPS) stimulation. Additionally, our observations suggest that IL-18 can induce priming of neutrophils for IL-1beta and, to a lesser extent, sIL-IRII production by LPS-stimulated cells. The ability of IL-18 to serve as an effective modulator for IL-1beta and its regulatory protein may have significance in the inflammatory and immune reactions mediated by IL-1beta.
Jabłońska
Ewa
E
Department of Immunology, Medical Academy of Białystok, Poland. ewaj@amb.edu.pl
Izycka
Aneta
A
Wawrusiewicz
Natalia
N
D006801:Humans; D066298:In Vitro Techniques; D018836:Inflammation Mediators / Q000378:metabolism; D007375:Interleukin-1 / Q000096:biosynthesis*; D020382:Interleukin-18 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology*; D017472:Receptors, Interleukin-1 / Q000096:biosynthesis*; D053574:Receptors, Interleukin-1 Type II; D011994:Recombinant Proteins / Q000494:pharmacology; D012995:Solubility
D018836:Inflammation Mediators; D007375:Interleukin-1; D020382:Interleukin-18; D008070:Lipopolysaccharides; D017472:Receptors, Interleukin-1; D053574:Receptors, Interleukin-1 Type II; D011994:Recombinant Proteins