title: Is the radon risk overestimated? Neglected doses in the estimation of the risk of lung cancer in uranium underground miners.
abstract: Only the exposure to inhaled radon decay products is usually taken into account in the determination of the risk of radiogenic lung cancer in uranium miners. However, the elevated lung cancer risk in uranium miners is due to the total dose of radiation received by that organ, not to the dose from inhaled radon-222 decay products (222Rn D.P.) alone. Lung doses from sources other than 222Rn D.P. may reach 25% to 75% of total effective dose, absorbed dose or equivalent lung dose, are correlated to 222Rn D.P. doses and are quite variable between facilities. Therefore, to neglect these doses leads to a systematic overestimation of the risk of lung cancer per unit 222Rn D.P. exposure, both through dose underestimation and dose misclassification. Correction for neglected doses and dose misclassification would pull the risk per unit radon exposure downward by a factor of at least two or three and bring the overall dose-effect relationship towards the no-effect null hypothesis, thereby increasing the likelihood of thresholds for lung cancer risk at indoor and today's uranium mine exposures.
authors.affiliation: International Centre for Low Dose Radiation Research, Institute of the Environment, University of Ottawa, Canada. pduport@uottawa.ca
authors.forename: P
authors.initials: P
authors.lastname: Duport
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology*; D008906:Mining; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D016273:Occupational Exposure; D011829:Radiation Dosage; D011886:Radon / Q000009:adverse effects*; D018570:Risk Assessment; D014501:Uranium / Q000009:adverse effects*
chemical_list: D014501:Uranium; D011886:Radon