Preparation of polyfunctional heterocycles using highly functionalized aminated arylmagnesium reagents as versatile scaffolds.
[reaction: see text] Functionalized Grignard reagents, derived from readily available o-iodoaniline derivatives and obtained via a straightforward iodine-magnesium exchange, can be used to prepare a wide range of polyfunctional indoles, quinolines, and quinazolinones.
Lindsay
David M
DM
Institut für Organische Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, Haus F, 81377 München, Germany.
Dohle
Wolfgang
W
Jensen
Anne Eeg
AE
Kopp
Felix
F
Knochel
Paul
P