Novel bicyclic oxazolone derivatives as anti-angiogenic agents.
Novel bicyclic tetrahydropyrano[3,2-d]oxazolones derivatives, analogues of Fumagillin, were synthesised via a stereocontrolled oxidative-rearrangement of furylcarbinols and subsequent treatment with the appropriate isocyanate. These compounds demonstrated potent antiangiogenic activity.
Perron-Sierra
Françoise M
FM
Institut de Recherches Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France. francoise.perron@fr.netgrs.com
Pierré
Alain
A
Burbridge
Mike
M
Guilbaud
Nicolas
N
D000482:Allantois / Q000098:blood supply / Q000187:drug effects; D020533:Angiogenesis Inhibitors / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply / Q000187:drug effects; D003510:Cyclohexanes; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D051379:Mice; D008968:Molecular Conformation; D018919:Neovascularization, Physiologic / Q000187:drug effects; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D010081:Oxazolone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D003510:Cyclohexanes; D005231:Fatty Acids, Unsaturated; D012717:Sesquiterpenes; D010081:Oxazolone; C026211:fumagillin; D000077609:O-(Chloroacetylcarbamoyl)fumagillol