title: Vaccination of C57BL/10 mice against cutaneous Leishmaniasis using killed promastigotes of different strains and species of Leishmania.
abstract: Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin(R) and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection.
authors.affiliation: Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG.
authors.forename: Wilson
authors.initials: W
authors.lastname: Mayrink
authors.forename: Gilmara Cristina dos
authors.initials: GC
authors.lastname: Santos
authors.forename: Vicente de Paulo Coelho Peixoto de
authors.initials: Vde P
authors.lastname: Toledo
authors.forename: Tânia Mara Pinto Dabés
authors.initials: TM
authors.lastname: Guimaraes
authors.forename: George Luis Lins
authors.initials: GL
authors.lastname: Machado-Coelho
authors.forename: Odair
authors.initials: O
authors.lastname: Genaro
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: da Costa
mesh_terms: D000818:Animals; D005260:Female; D007891:Leishmania / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000517:prevention & control / Q000662:veterinary*; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology*; D016052:Protozoan Vaccines / Q000627:therapeutic use*; D014611:Vaccination
chemical_list: D016052:Protozoan Vaccines