title: [Combination chemotherapy with carboplatin and etoposide for elderly patients aged 76 years or older with small cell lung cancer].
abstract: Eighteen elderly patients aged 76 years or older with small cell lung cancer were treated with carboplatin (AUC = 4 mg/ml.min, i.v. day 1) and etoposide (70 mg/m2 i.v. day 1-3) and 17 patients were evaluable. The median age of the study population was 77 years (range: 76-81). Eight patients had limited disease (LD) and nine did extensive disease (ED). The overall response rate was 88% for LD patients and 67% for ED patients. Median survival time was 219 days for LD patients and 158 days for ED patients. Grade 3 and 4 leukopenia, neutropenia, thrombocytopenia and anemia occurred in 41%, 76%, 24% and 6% of patients, respectively. There was one treatment-related death due to pneumonitis.
authors.affiliation: Dept. of Internal Medicine, National Minami-Okayama Hospital.
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Tada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueoka
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kiura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tabata
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Takemoto
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Yamane
authors.forename: Junichiro
authors.initials: J
authors.lastname: Hiyama
authors.forename: Keisuke
authors.initials: K
authors.lastname: Aoe
authors.forename: Takuo
authors.initials: T
authors.lastname: Shibayama
authors.forename: Haruhito
authors.initials: H
authors.lastname: Kamei
authors.forename: Shin
authors.initials: S
authors.lastname: Kawahara
authors.forename: Shingo
authors.initials: S
authors.lastname: Harita
authors.forename: Toshio
authors.initials: T
authors.lastname: Sato
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Kenji
authors.initials: K
authors.lastname: Eguchi
authors.forename: Shunkichi
authors.initials: S
authors.lastname: Hiraki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hiraki
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D015996:Survival Rate
chemical_list: D005047:Etoposide; D016190:Carboplatin