title: Prosthetic valve endocarditis due to vancomycin-resistant Enterococcus faecium: treatment with chloramphenicol plus minocycline.
abstract: We report a case of prosthetic valve endocarditis and persistent bacteremia due to vancomycin-resistant Enterococcus faecium. The combination of parenteral chloramphenicol plus minocycline therapy was administered for 8 weeks and resulted in cure after treatment with quinupristin-dalfopristin had failed.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of South Carolina School of Medicine, Columbia, SC, 29203, USA. Safdar@richmed.medpark.sc.edu
authors.forename: Amar
authors.initials: A
authors.lastname: Safdar
authors.forename: Charles S
authors.initials: CS
authors.lastname: Bryan
authors.forename: Shawn
authors.initials: S
authors.lastname: Stinson
authors.forename: Donald E
authors.initials: DE
authors.lastname: Saunders
mesh_terms: D000368:Aged; D002701:Chloramphenicol / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D016984:Enterococcus faecium; D006350:Heart Valve Prosthesis / Q000382:microbiology; D006801:Humans; D008297:Male; D008911:Minocycline / Q000627:therapeutic use*; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D020713:Vancomycin Resistance
chemical_list: D002701:Chloramphenicol; D008911:Minocycline