title: Imipenem use in serious childhood infections.
abstract: Imipenem plus cilastatin is a beta-lactam antibiotic with a broad spectrum and good tolerance. For this its use is indicated in serious infections even in children. The authors carried out a preliminary bacteriological study in patients affected by serious infection, cystic fibrosis, tumors, neutropenia, subjects undergoing intensive therapy and those with abdominal surgical infection. Isolated microorganism sensitivity in these patients, towards imipenem was very high (89%-100%). With these premises, 35 patients with serious infections in various locations were treated only with imipenem. Of these, 15 were oncologic neutropenic and 20 normal. In the first group therapeutic success was 66.6% and in the second one 80%. Local and systemic tolerance always showed good results.
authors.affiliation: Admittance Dept. Regina Margherita Children's Hospital, Turin, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Pavesio
authors.forename: P
authors.initials: P
authors.lastname: Pecco
authors.forename: M
authors.initials: M
authors.lastname: Giacchino
authors.forename: M
authors.initials: M
authors.lastname: Dotti
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy*; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D009369:Neoplasms / Q000150:complications; D009503:Neutropenia / Q000150:complications; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000188:drug therapy*; D013845:Thienamycins / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D013845:Thienamycins; D015378:Imipenem