Diabetic nephropathy in KK and KK-Ay mice.
KK mice and KK-Ay mice were examined for age related changes in blood and urinary biophysiological parameters. Blood hemoglobin A1c levels were significantly higher in KK-Ay and KK mice as compared to non-diabetic ddY mice. In both diabetic mice, especially KK-Ay mice, plasma insulin levels markedly increased at 2 to 4 months of age, and the urinary glucose and microalbumin levels and albumin-to-creatinine ratios increased dependent on age. Plasma thrombomodulin levels significantly increased at 2 to 4 months of age in both KK and KK-Ay mice. Mild enlargement of mesangial matrix and segmental proliferative glomerular nephritis were revealed in KK and KK-Ay mice, respectively, at 4 months of age. KK-Ay mice with insulin resistance and high urine mAlb level might be useful as models for the early stage of diabetic nephropathy.
Okazaki
Masako
M
Department of Pharmacology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8555, Japan.
Saito
Yukako
Y
Udaka
Yuko
Y
Maruyama
Mine
M
Murakami
Hidetomo
H
Ota
Sumiko
S
Kikuchi
Takuya
T
Oguchi
Katsuji
K
D000419:Albuminuria / Q000235:genetics; D000818:Animals; D003928:Diabetic Nephropathies / Q000097:blood / Q000235:genetics* / Q000473:pathology / Q000652:urine; D004195:Disease Models, Animal; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D008817:Mice, Mutant Strains / Q000235:genetics*; D013045:Species Specificity; D018180:Thrombomodulin / Q000097:blood
D006442:Glycated Hemoglobin; D007328:Insulin; D018180:Thrombomodulin