title: Periodontal regeneration following use of ABM/P-1 5: a case report.
abstract: ABM/P-15 is a combination of a natural anorganic bovine-derived hydroxyapatite matrix (ABM) and a synthetic cell-binding peptide (P- 15; PepGen P- 15) that has shown the capacity to encourage substantial clinical fill of periodontal infrabony defects. Human histology following its use has not been evaluated on pathologic root surfaces. A maxillary lateral incisor with advanced adult periodontitis that was treatment planned for extraction was treated with sulcular incisions, full-thickness flap reflection, debridement of granulomatous tissue from the defect, placement of a notch in the root at the apical extent of calculus, mechanical root planing, brief cleansing with citric acid, grafting with ABM/P-15, wound closure with sutures, and placement of a periodontal dressing. Biweekly to monthly recalls were made until removal of a small block section biopsy at about 6 months. Histologic evaluation of the region coronal to the apical edge of the calculus notch showed evidence of regeneration (new cementum, bone, and periodontal ligament). Graft particles were still present at 6 months, but no evidence of root resorption, ankylosis, or untoward inflammation was seen. This case report fulfills the proof of principle that use of ABM/P-15 can result in periodontal regeneration on previously diseased root surfaces in humans.
authors.affiliation: Department of Periodontics, Louisiana State University, School of Dentistry, New Orleans 70119-2799, USA.
authors.forename: Raymonda
authors.initials: R
authors.lastname: Yukna
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Salinas
authors.forename: Ronald F
authors.initials: RF
authors.lastname: Carr
mesh_terms: D000134:Acid Etching, Dental; D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery; D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D003094:Collagen / Q000627:therapeutic use*; D003739:Dental Cementum / Q000473:pathology; D017886:Durapatite / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006097:Granulation Tissue / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D007180:Incisor / Q000601:surgery; D010446:Peptide Fragments / Q000627:therapeutic use*; D017622:Periodontal Attachment Loss / Q000601:surgery; D010511:Periodontal Dressings; D010513:Periodontal Ligament / Q000473:pathology; D010514:Periodontal Pocket / Q000601:surgery; D010518:Periodontitis / Q000601:surgery*; D016745:Root Planing; D013357:Subgingival Curettage; D013524:Surgical Flaps; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D010446:Peptide Fragments; C407062:cell-binding peptide P-15; D003094:Collagen; D017886:Durapatite