New triruthenium clusters as photoinduced DNA-binding and cleaving agents.
1-Hydroxybenzotriazole and 1-hydroxypyridine-2-thione were incorporated as ligands with the cluster Ru3(CO)10 (NCMe)2 to give [(mu-H)Ru3(CO)10(mu2-2,3-eta2-NNN(O)C6 H4)] and [(mu-H)Ru3(CO)9(mu2-eta1 : eta2-C5H4N(O)S)], respectively. Irradiation of these two new triruthenium metal clusters individually with 350 nm UV light in a phosphate buffer (pH 6.0) containing form I DNA resulted in single-strand cleavage. Cluster [(mu-H)Ru3(CO)10(mu2-2,3--eta2-NNN (O)C6H4)] was also found to bind to calf thymus DNA upon UV irradiation.
Hwu
Jih Ru
JR
Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan, Republic of China. jrhwu@chem.sinica.edu.tw
Kuang-Lieh
L
L
Yu
Sheng-Fa
SF
Yu
Lee-Ju
LJ
Kumaresan
Sudalaiandi
S
Lin
Kuan-Jiun
KJ
Tsay
Shwu-Chen
SC
D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry / Q000187:drug effects* / Q000528:radiation effects*; D004249:DNA Damage; D008958:Models, Molecular; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D017975:Ruthenium Compounds / Q000737:chemistry / Q000494:pharmacology*
D017975:Ruthenium Compounds; D004247:DNA