title: Causes and consequences of pathogenic processes in evolution: implications from experimental epilepsy in animals.
abstract: Examples from experimental epilepsy in animals are used to illustrate the view that a crucial role of the transfer of mechanisms from compensatory into pathogenic (e.g. lethal ones in the course of a disease), is played by the power of pathologic stimuli. In the genesis of epilepsy it is suggested that a critical increase of endogenous factors may underlie the conversion of the absence form of epilepsy into a generalized self-supporting form. The ability to precipitate endogenous self-augmenting mechanisms of diseases may have increased in the course of evolution. The lethal result of a serious pathogenic process leads to the suggestion that organisms cope with the disease by dying. This prevents spreading of the putative infectious disease within the population. This mechanism of disease aggravation could play a role in the survival of the species and in further evolutionary progress. This may explain why certain species may have survived in evolution and supports the theory of synthetic evolution.
authors.affiliation: Department of Biophysics, Informatics and Medical Devices, Medical University, Odessa, Ukraine.
authors.forename: Leonid S
authors.initials: LS
authors.lastname: Godlevsky
authors.forename: G
authors.initials: G
authors.lastname: van Luijtelaar
authors.forename: A A
authors.initials: AA
authors.lastname: Shandra
authors.forename: A M L
authors.initials: AM
authors.lastname: Coenen
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004195:Disease Models, Animal; D004827:Epilepsy / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008962:Models, Theoretical