[Studies on the fine stereostructure of taxoids].
The anticancer drug taxol is a new type antimicrotubular drug. The structure-activity relationship study on taxol and its analogs has indicated the importance of the C13 side chain and the C4-C5-C20 epoxypropane group. The crystal structures of 4 taxoids having the basic skeleton with 5/7/6 membered ring and three types of 10 taxoids having the basic skeleton with 6/8/6 membered ring have been analyzed. The effects of the induction by different substructures at C4 on the stereostructures of taxoids were studied, and the relationship between the 6/8/6/4 skeleton and the anticancer activity was discussed from the crystallographic point.
Wu
N
N
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050.
Lu
Y
Y
Zheng
Q
Q
Fang
W
W
Gao
Y
Y
Fang
Q
Q
Zhou
T
T
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D003460:Crystallization; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel