Effect of uterine horn ligation on bone mass: an experimental study in rats.
OBJECTIVE
After tubal ligation, normal bone mass in the presence of gonadal deficit has been reported. These incongruent results motivated us to examine the topic.


METHODS
Bone mass was assessed by densitometry and ultrasonography 60 days after surgery on 100-day-old female Wistar rats. Fifteen Wistar rats with uterine horn ligation (TL) were compared with 15 unoperated, 15 with a sham uterine horn ligation (Sham-TL), and 15 ovariectomized (OVX), using ANOVA and a correlation test to determine the relations between results.


RESULTS
Femoral and vertebral bone mass were significantly lower in the OVX y TL groups than in unoperated and controls groups (P<0.0001).


CONCLUSIONS
Our study revealed significantly lower axial and peripheral bone mass in rats with uterine horn ligation.
Rico
Horatio
H
Department of Medicine and Medical Specialties, University of Alcalá de Henares, Madrid, Spain. horatio.rico@uab.es
Cuesta
C
C
Cortés
J
J
Seco
C
C
Monteagudo
M D
MD
Hernández
E R
ER
D000818:Animals; D015519:Bone Density; D005260:Female; D005269:Femur / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D008026:Ligation; D016014:Linear Models; D009929:Organ Size; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D014463:Ultrasonography; D014599:Uterus / Q000601:surgery*