title: Hypothesis: the protein body effect and other aspects of food matrix effects.
abstract: With regard to the allergenicity of edible seeds and nuts, certain proteins may not be immediately accessible to digestion in the stomach and the upper small intestine because of the nature of the organization of such proteins into protein body organelles. Protein body hydration status, interactions between proteins, phytochemicals, protease inhibitors, and other matrix effects may contribute to the ability of a protein or package of proteins to reach the sites of active immune sampling in the gastrointestinal mucosa and thus be an influence on the potential allergenicity of a protein.
authors.affiliation: Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, School of Medicine, Davis 95616, USA. ssteuber@ucdavis.edu
authors.forename: Suzanne S
authors.initials: SS
authors.lastname: Teuber
mesh_terms: D000485:Allergens / Q000737:chemistry; D005502:Food; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007073:Immunoglobulin E / Q000737:chemistry
chemical_list: D000485:Allergens; D007073:Immunoglobulin E