Valproate-associated stomatitis.
The purpose of this article is to report a case of severe stomatitis in a patient with pediatric epilepsy taking divalproex sodium. The case was reviewed with detailed oral examinations. This 5-year-old child developed severe stomatitis 18 months after institution of divalproex sodium. Cessation of the medication was associated with resolution of the stomatitis. A review of the pertinent literature is also provided. Stomatitis is a rare but potentially serious adverse effect of divalproex sodium administration.
Ryan
Melody
M
Department of Neurology, College of Medicine, University of Kentucky, Lexington 40536-0084, USA. maryan1@uky.edu
Baumann
Robert J
RJ
Miller
Craig S
CS
Baker
Chris
C
D000927:Anticonvulsants / Q000009:adverse effects*; D002675:Child, Preschool; D004569:Electroencephalography; D004829:Epilepsy, Generalized / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D013280:Stomatitis / Q000139:chemically induced*; D014635:Valproic Acid / Q000009:adverse effects*
D000927:Anticonvulsants; D014635:Valproic Acid