Nicotinanilides as inhibitors of neutrophil chemotaxis.
A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and allergic disorders.
Cutshall
Neil S
NS
Department of Chemistry, Celltech R&D Inc., 1631 220th Street SE, Bothell, WA 98021, USA. ncutshall@ceptyr.com
Kucera
Kristin A
KA
Ursino
Rocky
R
Latham
John
J
Ihle
Nathan C
NC
D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D009504:Neutrophils / Q000187:drug effects*; D009539:Nicotinic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D008024:Ligands; D009539:Nicotinic Acids; C038997:nicotinanilide