title: Plasticity of Pax-5(-/-) pre-B I cells.
abstract: In Pax-5 deficient mice, B cell development is blocked at the pre-B I cell stage. In contrast to their wild type counterparts, Pax-5(-/-) pre-B I cells posses an extraordinary developmental plasticity showing hematopoietic stem cell features such as pluripotency and self renewing capacity. Here we review the in vitro and in vivo evidence of this intriguing phenomenon.
authors.affiliation: Basel Institute for Immunology, Basel, Switzerland. lbruno@icr.ac.uk
authors.forename: Ludovica
authors.initials: L
authors.lastname: Bruno
authors.forename: Christoph
authors.initials: C
authors.lastname: Schaniel
authors.forename: Antonius
authors.initials: A
authors.lastname: Rolink
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D051757:PAX5 Transcription Factor; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D051757:PAX5 Transcription Factor; C497282:Pax5 protein, mouse; D014157:Transcription Factors