title: New diterpene glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber.
abstract: Three new diterpene glycosides, virescenosides O (1), P (2), and Q (3), have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures were determined on the basis of HRMALDIMS and NMR data as beta-D-altropyranosido-19-isopimara-8(14),15-diene-7alpha,3beta-diol (1), beta-D-altropyranosido-19-7-oxoisopimara-8(9),15-diene-3beta-ol (2), and beta-D-mannopyranosido-19-isopimara-7,15-diene-3beta-ol (3). The cytotoxic activity of the virescenosides was examined.
authors.affiliation: Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok 22, Russian Federation.
authors.forename: Shamil Sh
authors.initials: SSh
authors.lastname: Afiyatullov
authors.forename: Anatoly I
authors.initials: AI
authors.lastname: Kalinovsky
authors.forename: Tatyana A
authors.initials: TA
authors.lastname: Kuznetsova
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Isakov
authors.forename: Mikhail V
authors.initials: MV
authors.lastname: Pivkin
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: George B
authors.initials: GB
authors.lastname: Elyakov
mesh_terms: D000164:Acremonium / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor; D002942:Circular Dichroism; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006868:Hydrolysis; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012616:Sea Cucumbers; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D006027:Glycosides; C458533:virescenoside O; C458534:virescenoside P; C458535:virescenoside Q