Dyskinesias following neural transplantation in Parkinson's disease.
Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.
Hagell
Peter
P
Section of Restorative Neurology, Wallenberg Neuroscience Center, SE-221 84 Lund, Sweden.
Piccini
Paola
P
Björklund
Anders
A
Brundin
Patrik
P
Rehncrona
Stig
S
Widner
Håkan
H
Crabb
Lesley
L
Pavese
Nicola
N
Oertel
Wolfgang H
WH
Quinn
Niall
N
Brooks
David J
DJ
Lindvall
Olle
O
D016380:Brain Tissue Transplantation / Q000009:adverse effects*; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D018450:Disease Progression; D020820:Dyskinesias / Q000175:diagnosis / Q000209:etiology*; D004421:Dystonia / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D006948:Hyperkinesis / Q000175:diagnosis / Q000209:etiology; D008636:Mesencephalon / Q000166:cytology / Q000196:embryology / Q000637:transplantation; D008875:Middle Aged; D009474:Neurons / Q000637:transplantation*; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology; D011699:Putamen / Q000000981:diagnostic imaging / Q000503:physiopathology; D012189:Retrospective Studies; D013997:Time Factors; D014055:Tomography, Emission-Computed