Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.
New C3-substituted beta-lactamase inhibitors were prepared and evaluated against representative class A and class C enzymes. It was possible to improve simultaneous inhibitory activity of both classes of serine hydrolase. Other inhibitors showed high selectivity for either the class C cephalosporinases or the class A penicillinases. This represents the first time that cephalosporin-derived inhibitors have demonstrated selectivity for the class A beta-lactamases.
Buynak
John D
JD
Department of Chemistry, Southern Methodist University, Dallas, TX 75275-0314, USA. jbuynak@mail.smu.edu
Vogeti
Lakshminarayana
L
Doppalapudi
Venkata Ramana
VR
Solomon
George Martin
GM
Chen
Hansong
H
D002511:Cephalosporins / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D065093:beta-Lactamase Inhibitors
D002511:Cephalosporins; D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors