title: Molecular profiling of non-small cell lung cancer and correlation with disease-free survival.
abstract: Recent studies have suggested that information from gene expression profiles could be used to develop molecular classifications of cancer. We hypothesized that expression levels of specific genes in operative specimens could be correlated to recurrence risk in non-small cell lung cancer (NSCLC). We performed expression profiling using 19.2 K cDNA microarrays on tumor specimens from a total of 39 NSCLC patients with known clinical follow-up information. Statistical analysis and clustering approaches were used to determine patterns of gene expression segregating with clinical outcome. The results provide evidence that molecular subtyping of NSCLC can identify distinct profiles of gene expression correlating with disease-free survival.
authors.affiliation: Thoracic Oncology Site Group, Princess Margaret Hospital, Samuel Lunenfeld Research Institute of Mount Sinai Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Wigle
authors.forename: Igor
authors.initials: I
authors.lastname: Jurisica
authors.forename: Niki
authors.initials: N
authors.lastname: Radulovich
authors.forename: Melania
authors.initials: M
authors.lastname: Pintilie
authors.forename: Janet
authors.initials: J
authors.lastname: Rossant
authors.forename: Ni
authors.initials: N
authors.lastname: Liu
authors.forename: Chao
authors.initials: C
authors.lastname: Lu
authors.forename: James
authors.initials: J
authors.lastname: Woodgett
authors.forename: Isolde
authors.initials: I
authors.lastname: Seiden
authors.forename: Michael
authors.initials: M
authors.lastname: Johnston
authors.forename: Shaf
authors.initials: S
authors.lastname: Keshavjee
authors.forename: Gail
authors.initials: G
authors.lastname: Darling
authors.forename: Timothy
authors.initials: T
authors.lastname: Winton
authors.forename: Bobby-Joe
authors.initials: BJ
authors.lastname: Breitkreutz
authors.forename: Paul
authors.initials: P
authors.lastname: Jorgenson
authors.forename: Mike
authors.initials: M
authors.lastname: Tyers
authors.forename: Frances A
authors.initials: FA
authors.lastname: Shepherd
authors.forename: Ming Sound
authors.initials: MS
authors.lastname: Tsao
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D020411:Oligonucleotide Array Sequence Analysis