title: Synthesis and antiproliferative activity of a new compound containing an alpha-methylene-gamma-lactone group.
abstract: The biological activity of compound 9 obtained by introducing an alpha-methylene-gamma-butyrolactone group into 3-(4-hydroxyphenyl)propionic acid, 1, was studied for possible effects on HL-60 cells, murine splenocytes, and human peripheral mononuclear cells (PBMC). 9 induced apoptosis in the HL-60 cell line and has a clear capacity to inhibit proliferation induced in murine splenocytes and PBMC by different mitogenic agents with no apparent toxic side effects. 9 was synthesized from 1, and its structure and stereochemistry were elucidated by spectroscopic methods.
authors.forename: Antonio G
authors.initials: AG
authors.lastname: González
authors.forename: Margarita Hernández
authors.initials: MH
authors.lastname: Silva
authors.forename: Juan I
authors.initials: JI
authors.lastname: Padrón
authors.forename: Francisco
authors.initials: F
authors.lastname: León
authors.forename: Eduardo
authors.initials: E
authors.lastname: Reyes
authors.forename: Melchor
authors.initials: M
authors.lastname: Alvarez-Mon
authors.forename: Juan P
authors.initials: JP
authors.lastname: Pivel
authors.forename: José
authors.initials: J
authors.lastname: Quintana
authors.forename: Francisco
authors.initials: F
authors.lastname: Estévez
authors.forename: Jaime
authors.initials: J
authors.lastname: Bermejo
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis; D002478:Cells, Cultured; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: C458000:5-(2-(4-methoxyphenyl)ethyl)-3-methylene-4-methyldihydrofuran-2-one; D000970:Antineoplastic Agents; D015107:4-Butyrolactone