Mechanisms of embryonic coronary artery development.
Coronary artery development is a complex vasculogenic process that begins shortly after heart looping. Coronary vasculogenesis is regulated by the myocardium, but is spatially and temporally dependent on the epicardium and its precursor, the proepicardial organ, for the provision of coronary vascular progenitor cells. Better understanding of the mechanisms of coronary artery development may clarify mechanisms of disease and suggest new potential therapies for disorders of the coronary vasculature.
Morabito
Christopher J
CJ
Department of Pediatrics and Cardiovascular Research Institute, University of California San Francisco, 3333 California Street, Box 1245, San Francisco, CA 94118, USA.
Kattan
Javier
J
Bristow
James
J
D001158:Arteries / Q000196:embryology*; D003324:Coronary Artery Disease / Q000503:physiopathology; D003331:Coronary Vessels / Q000196:embryology*; D006801:Humans