Effect of superoxide dismutase deficiency on the life span of the yeast Saccharomyces cerevisiae. An oxygen-independent role of Cu,Zn-superoxide dismutase.
Effects of the absence of Cu,Zn-superoxide dismutase (CuZnSOD) on the replicative life span of the yeast Saccharomyces cerevisiae were studied under different oxygen conditions. In both strains, replicative life span and the rate of cell divisions were found to be similar under the atmosphere of air and under hypoxic (3% oxygen) and anoxic conditions. These results indicate that deleterious consequences of the lack of CuZnSOD are not limited to elevation of superoxide concentration and involve function(s) other than superoxide scavenging.
Wawryn
Jarosław
J
Zamość College of Agriculture, ul. Szczebrzeska 102, PL 22-400 Zamość, Poland.
Swieciło
Agata
A
Bartosz
Grzegorz
G
Biliński
Tomasz
T
D002455:Cell Division; D010100:Oxygen; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000502:physiology*; D013482:Superoxide Dismutase / Q000172:deficiency*
D013482:Superoxide Dismutase; D010100:Oxygen