Oral administration of swine gastric mucin alters levels of serum and urine nitric oxide, and lipid metabolism in mice.
Mice were fed with swine gastric mucin in a basal diet for 5 weeks. In 5 week-old mice, a 2% mucin diet significantly decreased nitric oxide levels of serum and liver. Reduction of serum total cholesterol and triglyceride and increase of HDL-cholesterol level were also significant with the mucin diet. In 14 month-old mice, the mucin diet was less effective.
Khedara
Abdelkrim
A
National Food Research Institute, Tsukuba, Ibaraki, Japan.
Miwa
Misao
M
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005752:Gastric Mucins / Q000008:administration & dosage / Q000494:pharmacology*; D050356:Lipid Metabolism; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009569:Nitric Oxide / Q000097:blood* / Q000652:urine*; D009929:Organ Size / Q000187:drug effects; D013552:Swine; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
D005752:Gastric Mucins; D014280:Triglycerides; D009569:Nitric Oxide; D002784:Cholesterol