title: [Synthesis and antitumor activity of new heterocyclic 5-fluorouracil derivatives].
abstract: Two new compounds I and II of 5-FU derivatives have been synthesized. The structures of the new compounds were confirmed by 1HNMR, MS, IR, UV and elemental analysis. The antitumor activities of compound I was tested against KB, HCT-8 and A2780. The preliminary results showed that the activity of compound I was stronger than that of HCFU and 5-FU.
authors.affiliation: Lanzhou Institute of Geology, Chinese Academy of Sciences.
authors.forename: M
authors.initials: M
authors.lastname: Mao
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Tian
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000964:Antimetabolites, Antineoplastic; D006571:Heterocyclic Compounds; D005472:Fluorouracil