title: Helicobacter pylori primary resistance to metronidazole and clarithromycin in Brazil.
abstract: Helicobacter pylori resistance to metronidazole was detected in 107 (52.97%) of 202 strains. Twenty (9.85%) strains, 18 of them harboring 23S ribosomal DNA mutations, were resistant to clarithromycin. Metronidazole resistance was associated with female gender. Resistance to metronidazole and resistance to clarithromycin were associated. Increasing clarithromycin resistance rates were observed over time.
authors.affiliation: Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Paula
authors.initials: P
authors.lastname: Prazeres Magalhães
authors.forename: Dulciene Maria
authors.initials: DM
authors.lastname: De Magalhães Queiroz
authors.forename: Daniela Vale
authors.initials: DV
authors.lastname: Campos Barbosa
authors.forename: Gifone
authors.initials: G
authors.lastname: Aguiar Rocha
authors.forename: Edilberto
authors.initials: E
authors.lastname: Nogueira Mendes
authors.forename: Adriana
authors.initials: A
authors.lastname: Santos
authors.forename: Paulo Renato
authors.initials: PR
authors.lastname: Valle Corrêa
authors.forename: Andreia Maria
authors.initials: AM
authors.lastname: Camargos Rocha
authors.forename: Lúcia
authors.initials: L
authors.lastname: Martins Teixeira
authors.forename: Celso
authors.initials: C
authors.lastname: Affonso de Oliveira
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000378:metabolism; D001938:Brazil / Q000453:epidemiology; D017291:Clarithromycin / Q000627:therapeutic use*; D004269:DNA, Bacterial / Q000235:genetics; D004352:Drug Resistance, Microbial; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use*; D017354:Point Mutation
chemical_list: D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C080866:cagA protein, Helicobacter pylori; D008795:Metronidazole; D017291:Clarithromycin