[Differentiation and cytogenesis of white rat pancreas endocrinocytes influenced by long-term fasting].
The structure and function of pancreatic islet cells was studied in white rats fasted for 2-6 days. The ultrastructural changes were detected in B-, A- and PP-cells; they were uniform and were most pronounced on day 6 of the experiment. These changes included degranulation of the cytoplasm, approaching of B-granules to and fusion with cell membrane, intracytoplasmic lysis of secretory material. Increased insulin secretion was accompanied by the appearance of "agranular" cells indicating high activity of cytogenesis of endocrine cells.
Vesnina
I A
IA
Department of Biomedical Research, Central Scientific Research Laboratory, St. Petersburg I.I. Metchnikov State Medical Academy.
D000818:Animals; D015550:Cell Degranulation; D002454:Cell Differentiation; D005215:Fasting; D010179:Pancreas / Q000166:cytology*; D051381:Rats