title: Multicenter study for the evaluation of a dedicated biopsy device for MR-guided vacuum biopsy of the breast.
abstract: The purpose of this multicenter study was to determine the accuracy and clinical value of a dedicated breast biopsy system which allows for MR-guided vacuum biopsy (VB) of contrast-enhancing lesions. In five European centers, MR-guided 11-gauge VB was performed on 341 lesions. In 7 cases VB was unsuccessful. This was immediately realized on postinterventional images or direct follow-up combined with histopathology-imaging correlation; thus, a false-negative diagnosis was avoided. Histology of 334 successful biopsies yielded 84 (25%) malignancies, 17 (5%) atypical ductal hyperplasias, and 233 (70%) benign entities. Verification of malignant or borderline lesions included reexcision of the biopsy cavity. Benign histologic biopsy results were verified by retrospective correlation with the pre- and postinterventional MRI and by subsequent follow-up. Our results indicate that MR-guided VB, in combination with the dedicated biopsy coil, offers the possibility to accurately diagnose even very small lesions that can only be visualized or localized by MRI.
authors.affiliation: Institute of Clinical Radiology, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Perlet
authors.forename: A
authors.initials: A
authors.lastname: Heinig
authors.forename: X
authors.initials: X
authors.lastname: Prat
authors.forename: J
authors.initials: J
authors.lastname: Casselman
authors.forename: L
authors.initials: L
authors.lastname: Baath
authors.forename: H
authors.initials: H
authors.lastname: Sittek
authors.forename: C
authors.initials: C
authors.lastname: Stets
authors.forename: J
authors.initials: J
authors.lastname: Lamarque
authors.forename: I
authors.initials: I
authors.lastname: Anderson
authors.forename: P
authors.initials: P
authors.lastname: Schneider
authors.forename: P
authors.initials: P
authors.lastname: Taourel
authors.forename: M
authors.initials: M
authors.lastname: Reiser
authors.forename: S H
authors.initials: SH
authors.lastname: Heywang-Köbrunner
mesh_terms: D001706:Biopsy / Q000295:instrumentation* / Q000379:methods; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging