[Level of serum tumor necrosis factor-alpha and the degree of liver fibrosis in children with chronic viral hepatitis B, C and B+C, treated with interferon-alpha].
Children with chronic virus hepatitis B and C, as well as combined chronic virus hepatitis B + C, were found to have a higher level of tumor necrosis factor-alpha (TNF-alpha) in their serum than healthy children. Complete clinical and virological response to treatment with interferon-alpha is accompanied by a decreased inflammation and fibrosis of the liver, as well as by a decreased level of TNF-alpha, in comparison with nonresponsive patients. Positive correlation between the level of TNF-alpha and the degree of liver fibrosis in sick children was noted.
Filimonov
P N
PN
Medical Academy, Institute of Clinical Immunology, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk, Russia.
Sukhenko
T G
TG
Gavrilova
N I
NI
D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use*; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005355:Fibrosis; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008103:Liver Cirrhosis / Q000097:blood* / Q000150:complications / Q000473:pathology / Q000821:virology; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D000998:Antiviral Agents; D015415:Biomarkers; D007370:Interferon Type I; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha