title: The application of molecular techniques to solid tumors.
abstract: Recent developments in the field of molecular biology including the sequencing of the human genome and related high throughput methodologies are presenting the diagnostic pathologist with new opportunities to expand our understanding of human disease. These techniques enable the comprehensive assessment of molecular alterations with cell populations of interest, including cancer. It will be necessary for the diagnostic pathologist to become familiar with these techniques to effectively translate their potential into the clinical environment.
authors.affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA.
authors.forename: Sean L
authors.initials: SL
authors.lastname: O'Connor
authors.forename: Jeong Hee
authors.initials: JH
authors.lastname: Cho
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: McDonnell
mesh_terms: D004273:DNA, Neoplasm / Q000032:analysis*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D025202:Molecular Diagnostic Techniques; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics; D009693:Nucleic Acid Hybridization / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011506:Proteins / Q000737:chemistry; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D004273:DNA, Neoplasm; D011506:Proteins