Social relationships, gender, and allostatic load across two age cohorts.
OBJECTIVE
This article addresses the question of biological pathways through which social integration and support may affect morbidity and mortality risks. A new concept of cumulative biological risk, allostatic load, is used to test the hypothesis that social experiences affect a range of biological systems. Data from two community-based cohorts are examined to evaluate the consistency of findings across two different age groups.


METHODS
One cohort included older adults aged 70 to 79 years (N = 765); the other cohort included persons aged 58 to 59 years (N = 106). Allostatic load was assessed using identical protocols in the two cohorts. Measures of social experience were similar but not identical, reflecting levels of social integration and support for the older cohort vs. childhood and adult experiences of loving/caring relationships with parents and spouse for the younger cohort. Gender-specific analyses were examined to evaluate possible gender differences in patterns of association.


RESULTS
In the younger cohort, positive cumulative relationship experiences were associated with lower allostatic load for men and women. In the older cohort, men who were more socially integrated and those reporting more frequent emotional support from others had lower allostatic load scores; similar but nonsignificant associations were seen for women.


CONCLUSIONS
Evidence from two cohorts provides support for the hypothesis that positive social experiences are associated with lower allostatic load. These findings are consistent with the hypothesis that social experiences affect a range of biological systems, resulting in cumulative differences in risks that in turn may affect a range of health outcomes.
Seeman
Teresa E
TE
Division of Geriatrics, School of Medicine, University of California, Los Angeles, California, USA. tseeman@mednet.ucla.edu
Singer
Burton H
BH
Ryff
Carol D
CD
Dienberg Love
Gayle
G
Levy-Storms
Lené
L
D000368:Aged; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005783:Gender Identity; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D008875:Middle Aged; D011602:Psychophysiologic Disorders / Q000401:mortality* / Q000523:psychology; D018570:Risk Assessment; D016019:Survival Analysis; D014481:United States