[Evidence based treatment of dyslipidemia associated with diabetes mellitus].
Diabetic patients are more prone to develop atherosclerosis. Coronary heart disease (CHD), cerebrovascular disease(CVD), and peripheral arterial disease(PAD) are three main life-threatening macrovascular complications in diabetes. Previous studies indicate that glycemic control is important. They also indicate that glycemic control does not sufficiently prevent the development of atherosclerotic diseases in diabetic patients. It is now clear that treatment of dyslipidemia and hypertension are as important as good glycemic control. Diabetic patients tend to develop dyslipidemia and hypertension, as both derives from insulin resistance. Many randomized control studies have proved that lowering of LDL-cholesterol is beneficial for preventing the development of CHD or CVD. Sub-analyses of RCT of statins suggest that lipid lowering therapy helps prevent the development of these macrovascular complications.
Odawara
Masato
M
Department of Endocrinology and Metabolism, Toranomon Hospital.
D002986:Clinical Trials as Topic; D048909:Diabetes Complications; D019317:Evidence-Based Medicine; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*