Building an efficient factory: where is pre-rRNA synthesized in the nucleolus?
The subnucleolar structure that is involved in rDNA transcription has been controversial. A report by Koberna et al. (2002)(this issue, page 743) adds significant weight toward the idea that dense fibrillar components (DFCs)**Abbreviations used in this paper: DFC, dense fibrillar component; FC, fibrillar center; GC, granular component; Pol I, polymerase I. and fibrillar center (FC)/DFC borders are the sites of pre-rRNA synthesis.
Huang
Sui
S
Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA. s-huang2@northwestern.edu
D000818:Animals; D002466:Cell Nucleolus / Q000235:genetics* / Q000378:metabolism*; D008322:Mammals; D012322:RNA Precursors / Q000096:biosynthesis*
D012322:RNA Precursors