title: Inhibitory effect of 1-benzyl-5[(C)-2,6-dimethyl-1,5-heptadienyl] imidazole (KK-42) on desert locust, Schistocerca gregaria forsk.
abstract: Imidazole compound KK-42 was tested for its inhibitory effect on Schistocerca gregaria. The compound caused 80% mortality after 19 days of treatment with 100 microg of KK-42/insect. It also caused the production of deformed adults at even lower doses. Ecdysteroid content, when estimated by RIA, declined due to KK-42 treatment in both haemolymph and ovaries of the insect. Reduction in ecdysteroid titer was maximum at 100 microg of KK-42/insect. The value estimated by RIA was 0.34 ng/pL haemolymph as compared to 0.97 ng/microL in case of controls. Similarly,ecdysteroid content of ovaries detected was 0.48 ng/mg in treated ones as compared to 0.61 ng/mg in controls. Histological studies, however, revealed no alteration in the ovarian tissues due to KK-42 treatment.
authors.affiliation: Department of Zoology, University of Delhi, India.
authors.forename: A
authors.initials: A
authors.lastname: Kumari
authors.forename: U
authors.initials: U
authors.lastname: Kumar
authors.forename: H C
authors.initials: HC
authors.lastname: Agarwal
mesh_terms: D000818:Animals; D005260:Female; D006110:Grasshoppers / Q000187:drug effects* / Q000502:physiology; D007093:Imidazoles / Q000494:pharmacology*; D007605:Juvenile Hormones / Q000494:pharmacology*; D009866:Oogenesis / Q000187:drug effects
chemical_list: D007093:Imidazoles; D007605:Juvenile Hormones; C063652:1-benzyl-5-(2,6-dimethyl-1,5-heptadienyl)imidazole