Creutzfeldt-Jakob disease 38 years after diagnostic use of human growth hormone.
A 47 year old man is described who developed pathology proven Creutzfeldt-Jakob disease (CJD) 38 years after receiving a low dose of human derived growth hormone (hGH) as part of a diagnostic procedure. The patient presented with a cerebellar syndrome, which is compatible with iatrogenic CJD. This is the longest incubation period described so far for iatrogenic CJD. Furthermore, this is the first report of CJD after diagnostic use of hGH. Since the patient was one of the first in the world to receive hGH, other cases of iatrogenic CJD can be expected in the coming years.
Croes
E A
EA
Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus University Medical Centre Rotterdam, PO Box 1738, 3000 DR Rotterdam, Netherlands.
Roks
G
G
Jansen
G H
GH
Nijssen
P C G
PC
van Duijn
C M
CM
D017668:Age of Onset; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D019382:Human Growth Hormone / Q000009:adverse effects*; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D019382:Human Growth Hormone