title: A case of hypereosinophilic syndrome presenting mid-ventricular obstruction.
abstract: A 59-year-old man with hypereosinophilic syndrome (HES) who had been maintained with low-dose prednisolone for 5 years developed the characteristic features of hypertrophic cardiomyopathy. Left ventricular endomyocardial biopsy revealed no eosinophilic infiltration but extensive myocardial fibrosis. Cardiac involvement in HES presents as endocardial fibrosis, resulting in a clinical presentation of restrictive cardiomyopathy. HES heart disease can also present dilated cardiomyopathy, but myocardial hypertrophy has only rarely been noted in conjunction with HES. This report concerns a patient with HES who had clinical and hemodynamic evidence of asymmetric septal hypertrophy with mid-ventricular obstruction.
authors.affiliation: Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakaoka
authors.forename: Kota
authors.initials: K
authors.lastname: Iwahori
authors.forename: Keita
authors.initials: K
authors.lastname: Kunisada
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fujio
authors.forename: Masahiro
authors.initials: M
authors.lastname: Izumi
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Osugi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oshima
authors.forename: Hisao
authors.initials: H
authors.lastname: Hirota
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamauchi-Takihara
mesh_terms: D009202:Cardiomyopathies / Q000473:pathology*; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D005355:Fibrosis; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology