Facile synthesis of 1-thio-beta-lactoside clusters scaffolded onto p-methoxyphenyl, beta-D-galactopyranoside, beta-D-glucopyranoside, and lactoside.
The free-radical addition of 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl-(1-->4)-2,3,6-tri-O-acetyl-1-thio-beta-D-glucopyranose to the allyl ether functions of p-methoxyphenyl per-O-allyl-D-galactopyranoside, D-glucopyranoside, and lactoside provides a concise and effective route for synthesis of glycoside clusters, of use for exploring anti-metastatic activity.
Meng
Xiang-Bao
XB
Department of Chemical Biology, School of Pharmaceutical Science, National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China.
Yang
Lian-Dai
LD
Li
Hui
H
Li
Qing
Q
Cheng
Tie-Ming
TM
Cai
Meng-Shen
MS
Li
Zhong-Jun
ZJ
D005690:Galactose / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy
D006027:Glycosides; C008245:lactosides; D005690:Galactose