Fibronexus in "malignant fibrous histiocytoma" of the bone: a case report of pleomorphic myofibrosarcoma.
The fibronexus (fibronexus junction) has been thought to be a characteristic ultrastructural feature of myofibroblasts, but it is controversial whether the fibronexus is also a characteristic of various myofibroblastic tumors. We report here a case of pleomorphic bone sarcoma (pleomorphic/storiform malignant fibrous histiocytoma) with fibronexus junctions arising in the head of the left humerus of a 70-year-old woman. By light microscopy the tumor was composed of large spindle or polygonal cells occasionally arranged in fascicles. Foamy giant cells with bizarre nuclei were not uncommon. Immunohistochemically, the tumor cells were positive diffusely for vimentin and focally for muscle actin (HHF35) and alpha-smooth muscle actin but were negative for desmin, high-molecular weight caldesmon, and S-100 protein. Ultrastructurally, the tumor cells had indented nuclei and spindle or polygonal cytoplasm, with little rough endoplasmic reticulum and small vesicles, and rather numerous mitochondria. The tumor cells had myofilaments with focal densities in the periphery, fibronectin fibrils adjacent to intracellular myofilaments, and by definition, therefore, fibronexus junctions. These findings suggest myofibroblastic differentiation, and a diagnosis of pleomorphic myofibrosarcoma is thought to be appropriate. We believe that the fibronexus is a characteristic and useful ultrastructural feature for differentiating myofibroblastic tumors from other pleomorphic myogenic sarcomas.
Watanabe
Kazuo
K
Pathology Division, Fukushima Medical University School of Medicine Hospital, Japan. w-kazuo@fmu.ac.jp
Ogura
Go
G
D008841:Actin Cytoskeleton / Q000648:ultrastructure*; D000199:Actins / Q000648:ultrastructure; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001859:Bone Neoplasms / Q000737:chemistry / Q000601:surgery / Q000648:ultrastructure*; D003937:Diagnosis, Differential; D005260:Female; D005347:Fibroblasts / Q000737:chemistry / Q000648:ultrastructure; D005353:Fibronectins / Q000648:ultrastructure*; D005354:Fibrosarcoma / Q000737:chemistry / Q000601:surgery / Q000648:ultrastructure*; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry / Q000648:ultrastructure*; D006801:Humans; D007124:Immunoenzyme Techniques; D007365:Intercellular Junctions / Q000648:ultrastructure; D009363:Neoplasm Proteins / Q000032:analysis; D015388:Organelles / Q000648:ultrastructure; D016896:Treatment Outcome
D000199:Actins; D014408:Biomarkers, Tumor; D005353:Fibronectins; D009363:Neoplasm Proteins