title: Production of 1,3-propanediol by Klebsiella pneumoniae.
abstract: 1,3-Propanediol (1,3-PD) has numerous applications from polymers to cosmetics, foods, lubricants, and medicines. Recently, there are strong industrial interests in a new kind of polyester, polytrimethylene terephthalate, with 1,3-PD as a monomer. This new polyester shows significant promise for use in carpeting and textiles. In this article we introduce a mild aerobic fermentation process using a strain screened from Klebsiella pneumoniae ATCC 25955, which is insensitive to oxygen, to produce 1,3-PD. We also describe a two-step fermentation process starting with glucose that was converted into glycerol with a glycerol-producing yeast, followed by K. pneumoniae that converts glycerol into 1,3-PD without intermediate isolation and purification of glycerol.
authors.affiliation: School of Chemical Engineering and Laboratory of Renewable Resources Engineering, Purdue University, West Lafayette, IN 47906, USA. hh@ecn.purdue.edu
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.forename: Cheng S
authors.initials: CS
authors.lastname: Gong
authors.forename: George T
authors.initials: GT
authors.lastname: Tsao
mesh_terms: D000332:Aerobiosis; D000693:Anaerobiosis; D001709:Biotechnology / Q000379:methods; D005285:Fermentation; D005504:Food Analysis; D005990:Glycerol / Q000378:metabolism; D007700:Kinetics; D007711:Klebsiella pneumoniae / Q000254:growth & development / Q000378:metabolism*; D008153:Lubrication; D008954:Models, Biological; D011108:Polymers; D011409:Propylene Glycols / Q000378:metabolism*
chemical_list: D011108:Polymers; D011409:Propylene Glycols; C041787:1,3-propanediol; D005990:Glycerol