title: Novel dipeptide macrocycles from 4-oxo, -thio, and -amino-substituted proline derivatives.
abstract: Dipeptide macrocycles of type A have been constructed in a versatile manner from the corresponding 4-heteroatom-substituted proline derivatives using an intramolecular Mitsunobu strategy.
authors.affiliation: Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. ashok.arasappan@spcorp.com
authors.forename: Ashok
authors.initials: A
authors.lastname: Arasappan
authors.forename: Kevin X
authors.initials: KX
authors.lastname: Chen
authors.forename: F George
authors.initials: FG
authors.lastname: Njoroge
authors.forename: Tejal N
authors.initials: TN
authors.lastname: Parekh
authors.forename: Viyyoor
authors.initials: V
authors.lastname: Girijavallabhan
mesh_terms: D003500:Cyclization; D004151:Dipeptides / Q000138:chemical synthesis*; D015195:Drug Design; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry; D053778:Thiazolidines
chemical_list: D004151:Dipeptides; D013844:Thiazoles; D053778:Thiazolidines; C036784:4-ketoproline; D011392:Proline; C003438:thiazolidine-4-carboxylic acid