[Studies on chemical components of Carthamus tinctorius petals].
The flower petals of Carthamus tinctorius L. (Compositae) provide one of the most important drugs in traditional Chinese medicine[1] used for the treatment of gynecological diseases, heart diseases and inflammation[2]. Carthamin, safflor yellows A and B, safflomin A, and C, isocarthamin, isocarthamidin, hydroxysafflor yellow A, and tinctormine have been reported from these petals, as well as several new flavonoids and phenolic compounds[3]. A continuation of these studies has led to the isolation of four compounds including a new flavonoid glucoside. The dried petals of C. tinctorius, cultivated in Sichuan, China, were extracted with 95% ethanol, and the extract was partitioned between H2O and organic solvents (petroleum ether and EtOAc). The water fraction was subjected to Diaion D101 and Sephadex LH-20 column chromatography with elution by a gradient of EtOH in water to yield compounds 1-4. Compound I is 6-hydroxykaempferol 3-O-glucoside, compound II is a new compound named 6-hydroxykaempferol 7-O-glucoside, compound 3 is kaempferol 3-O-rutinoside and compound 4 is quercetin 3-O-glucoside.
Li
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Y
Department of Natural Medicines, School of Pharmaceutical Sciences, Bijing Medical University, Beijing 100083.
Che
Q
Q
D031187:Carthamus tinctorius / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D044949:Kaempferols; D015394:Molecular Structure
C470040:6-hydroxykaempferol-3-O-glucoside; D005419:Flavonoids; D005960:Glucosides; D044949:Kaempferols