title: Determination of active substances in antiallergic and antiphlogistic multicomponent preparations by high performance liquid chromatography (HPLC).
abstract: The aim of the present study was the elaboration of an HPLC method enabling the identification and determination of the content of selected compounds occurring in multicomponent preparations applied in allergic and non-allergic diseases of upper respiratory tracts. These compounds include: buzepide methyl iodide, clocinizine dihydrochloride, phenylpropanolamine hydrochloride, pseudoephedrine sulfate and dexbrompheniramine maleate. The elaborated HPLC method shows that a good separation of the mentioned compounds is feasible. The regression analysis has demonstrated linearity of the method in concentration range suitable for the intended experiments. The determination of the compounds in pharmaceutical preparations and the statistical evaluation of the results indicate that both the selectivity and precision of the method are good.
authors.affiliation: Drug Institute, Warszawa, Poland.
authors.forename: Wanda
authors.initials: W
authors.lastname: Białecka
authors.forename: Anna
authors.initials: A
authors.lastname: Kulik
authors.forename: Teresa
authors.initials: T
authors.lastname: Kaniewska
mesh_terms: D018926:Anti-Allergic Agents / Q000032:analysis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000706:statistics & numerical data; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry
chemical_list: D018926:Anti-Allergic Agents; D004364:Pharmaceutical Preparations