[Acute phase proteins and recurrence of angina after effective coronary angioplasty].
OBJECTIVE
Analysis of relationships between clinical characteristics of the patients, high concentration of acute phase proteins--fibrinogen, C-reactive protein (CRP), activity of the inhibitor of type 1 plasminogen activator (PAI-1)--and frequency of angina recurrence after successful coronary angioplasty (CA).


METHODS
The trial included 53 patients after successful CA for a single hemodynamically significant stenosis. Peripheral blood was examined for plasm fibrinogen, CRP, activity of PAI-1 one day before and 2 days, 3 and 6 months after CA. After 12-month follow-up the patients were divided into two groups: angina-free patients (n = 37) and with recurrent angina (n = 16).


RESULTS
Significant differences between the above groups were in PAI-1 activity 3 and 6 months after CA, in CRP initially, on day 2, after 6 months after CA (p < 0.05) but multifactor analysis has found that only CRP level both initial and on day 2 after CA is an independent predictor of recurrent angina pectoris after successful CA.


CONCLUSIONS
An anginal recurrence after successful CA can be predicted by the initial and postoperative day 2 levels of CRP.
Alekseeva
I A
IA
Liakishev
A A
AA
Tkachuk
V A
VA
Dobrovol'skiĭ
A B
AB
Nasonov
E L
EL
Naumov
V G
VG
Parfenova
E V
EV
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood*; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D023903:Coronary Restenosis / Q000097:blood*; D005163:Factor Analysis, Statistical; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011237:Predictive Value of Tests; D012008:Recurrence; D012307:Risk Factors
D000209:Acute-Phase Proteins; D015415:Biomarkers; D017395:Plasminogen Activator Inhibitor 1; D005340:Fibrinogen; D002097:C-Reactive Protein