Evaluation of the antinflammatory and analgesic activity of Sideritis canariensis var. pannosa in mice.
A previous chemical study of Sideritis canariensis var. pannosa demonstrated the presence of some important classes of related organic compounds with anti-inflammatory activities. In the present study, the crude ethanol extract and the chloroformic and aqueous fractions of S. canariensis have been examined for their antimicrobial actions through the disk-diffusion method and for their anti-inflammatory and analgesic effects in several animal models. No relevant antimicrobial activity against the tested microorganisms was found. The chloroformic fraction was the most interesting, exhibiting a good analgesic and anti-inflammatory activity.
Hernández-Pérez
Margarita
M
Departamento de Enfermería, E.U. de Enfermería y Fisioterapia, Universidad de La Laguna, C/Campus de Ofra, s/n, 38071, La Laguna, Tenerife, Spain. maherpe@ull.es
Rabanal
Rosa M
RM
D019342:Acetic Acid / Q000494:pharmacology; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002351:Carrageenan / Q000494:pharmacology; D002725:Chloroform; D004058:Diffusion; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy; D000431:Ethanol; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000627:therapeutic use*; D031365:Sideritis
D000700:Analgesics; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D000431:Ethanol; D002725:Chloroform; D002351:Carrageenan; D019342:Acetic Acid