title: Clinical features of prostate cancer patients younger than 50 years: report of seven cases.
abstract: BACKGROUND
  The incidence of prostate cancer increases with age and latent cancer is common in older men. But clinical prostate cancer is rare in men aged < 50 years.
  
  
  METHODS
  Between 1988 and 2000, we studied seven cases of prostate cancer in men aged under 50 years. The clinicopathological results included: the first sign or symptom; prostate-specific antigen (PSA) at the time of diagnosis; existence of abnormal digital rectal examination (DRE); the differentiation of the cancer and Gleason score; and the outcome of treatment.
  
  
  RESULTS
  Six cases were diagnosed as stage D2. One case was diagnosed as stage B2 and the patient underwent radical prostatectomy. None of the cases were detected by mass screening. The PSA at diagnosis was < 10 ng/mL in only one case and that patient underwent radical prostatectomy. Six cases were diagnosed pathologically as poorly differentiated adenocarcinoma. The only patient who survived more than 5 years underwent radical prostatectomy.
  
  
  CONCLUSIONS
  Six of seven cases of prostate cancer were detected at advanced stage. Only one case was thought to be curable and this patient's cancer was detected by chance occult blood test. Because young prostate cancer patients are potential candidates for radical prostatectomy and the sensitivity of PSA might be higher in young men, high-risk groups could be screened by PSA.
authors.affiliation: Department of Urology,Tohoku University School of Medicine, Aoba-ku, Sendai, Miyagi, Japan. skanto@mail.cc.tohoku.ac.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Kanto
authors.forename: Chikara
authors.initials: C
authors.lastname: Ohyama
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Okada
authors.forename: Shiro
authors.initials: S
authors.lastname: MitSukawa
authors.forename: Jun
authors.initials: J
authors.lastname: Takemoto
authors.forename: Senji
authors.initials: S
authors.lastname: Hoshi
authors.forename: Seiichi
authors.initials: S
authors.lastname: Orikasa
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis; D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D010173:Palpation; D017430:Prostate-Specific Antigen / Q000032:analysis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D017430:Prostate-Specific Antigen