title: Spitz nevus of the tongue with pseudoepitheliomatous hyperplasia: report of three cases of a pseudomalignant condition.
abstract: Three cases of Spitz nevus of the tongue associated with pseudoepitheliomatous hyperplasia are reported: two occurring in children and one in an adult. The location at an unusual site and the complex pattern resulting from the intimate admixture of the neoplastic melanocytic component and the hyperplastic keratinocytic component led in each case to consider diagnoses such as malignant melanoma and invasive squamous cell carcinoma. Staining for S-100 protein and keratin was useful to identify and separate the two components. Spitz nevus of the tongue carries some intriguing similarities with granular cell tumor, suggesting a possible histogenetic and pathogenetic relationship.
authors.affiliation: Department of Pathology, University of Bologna Medical School, Italy.
authors.forename: Tshering
authors.initials: T
authors.lastname: Dorji
authors.forename: Alberto
authors.initials: A
authors.lastname: Cavazza
authors.forename: Oscar
authors.initials: O
authors.lastname: Nappi
authors.forename: Juan
authors.initials: J
authors.lastname: Rosai
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism; D018332:Nevus, Epithelioid and Spindle Cell / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014062:Tongue Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D009418:S100 Proteins; D007633:Keratins