First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution.
The first fluorescent chemosensors toward a native phosphorylated peptide are successfully synthesized. Dinuclear zinc(II)-dipicolylamine-based anthracene (1, 2) can selectively recognize and sense phosphorylated species with an increase in the fluorescence intensity. We also demonstrated that these artificial receptors fluorometrically detect a phosphorylated peptide with high affinity (>107 M-1) in aqueous solution.
Ojida
Akio
A
Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Fukuoka, 812-8581, Japan.
Mito-Oka
Yasuko
Y
Inoue
Masa-Aki
MA
Hamachi
Itaru
I
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D000595:Amino Acid Sequence; D000873:Anthracenes / Q000138:chemical synthesis / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010748:Phosphopeptides / Q000737:chemistry*; D019000:Phosphotyrosine / Q000737:chemistry; D018000:Receptors, Peptide / Q000737:chemistry*; D012996:Solutions; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
D000588:Amines; D000873:Anthracenes; D005456:Fluorescent Dyes; D009842:Oligopeptides; D009942:Organometallic Compounds; D010748:Phosphopeptides; D018000:Receptors, Peptide; D012996:Solutions; D014867:Water; D019000:Phosphotyrosine; D015032:Zinc