[Effects of leukotrienes on production of interleukin 6 from mouse peritoneal macrophages].
In the present study, effects of leukotrienes on IL-6 production by mouse resident peritoneal macrophages were explored with a bioassay method involving IL-6 dependent murine hybridoma B9 cell line. The results showed that LTB4, LTC4 and LTD4 can enhance the production of IL-6 from cultured peritoneal macrophages of mice. The optimal concentractions for LTB4, LTC4 and LTD4 were found to be 1.45 x 10(-6), 6.9 x 10(-8) and 8.05 x 10(-8) mol.L-1, respectively. The results suggest that peptide leukotrienes might play important role on IL-6 production in the local milieu of inflammation.
Zhong
M
M
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050.
Cheng
G
G
Wang
W
W
Zhou
L
L
Zhu
X
X
Zhang
J
J
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D015850:Interleukin-6 / Q000096:biosynthesis*; D007975:Leukotriene B4 / Q000494:pharmacology; D017997:Leukotriene C4 / Q000494:pharmacology; D017998:Leukotriene D4 / Q000494:pharmacology; D015289:Leukotrienes / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL
D015850:Interleukin-6; D015289:Leukotrienes; D007975:Leukotriene B4; D017997:Leukotriene C4; D017998:Leukotriene D4