Lactic dehydrogenase virus (LDV) infection inhibits allergic eosinophil reaction in the airway.
The effects of interferon (IFN)-gamma induced by virus infection on eosinophil reaction in allergic airway inflammation are not yet clear. We investigated the effects of lactic dehydrogenase virus (LDV) infection, which increases IFN -gamma production with no viral infection or replication in respiratory epithelium, on allergic airway hypersensitivity. LDV infection suppressed antigen-induced eosinophil recruitment into the airway in sensitized mice. IL -5 gene expression in bronchoalveolar lavage (BAL) cells was significantly suppressed in LDV -infected mice compared with uninfected controls. The numbers of total T cells and CD 4+ T cells were significantly reduced in LDV -infected mice compared with controls. The present results suggested that the increase in production of IFN -gamma by viral infection suppresses the eosinophil reaction, and this suppressive effect may be mediated by inhibition of the recruitment of CD 4+ T cell and IL -5 production.
Morimoto
M
M
Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan.
Ohji
T
T
Iwata
H
H
Hayashi
T
T
D000485:Allergens / Q000276:immunology; D000818:Animals; D018174:Arterivirus Infections / Q000276:immunology*; D001483:Base Sequence; D018893:Bronchoalveolar Lavage; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004804:Eosinophils / Q000276:immunology*; D005786:Gene Expression Regulation; D006967:Hypersensitivity / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology; D015848:Interleukin-5 / Q000096:biosynthesis / Q000235:genetics; D007772:Lactate dehydrogenase-elevating virus / Q000276:immunology*; D008297:Male; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012137:Respiratory System / Q000276:immunology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012376:Rodent Diseases / Q000276:immunology / Q000821:virology
D000485:Allergens; D015848:Interleukin-5; D012333:RNA, Messenger; D007371:Interferon-gamma; D010047:Ovalbumin