L-Homoserine: a novel excreted metabolic marker of hepatitis B abnormally produced in liver from methionine.
The hepatitis B infection leads to various profound pathological processes in liver metabolism. Some biochemical alterations detectable by blood analysis are currently used for a preliminary evaluation of the infection. Based on existing data we present here evidence that non-protein amino acid L-homoserine is a pathological, hepatitis B-induced metabolite that is formed and excreted into urine from methionine via splitting S-adenosylmethionine. The urine L-homoserine is proposed as a new marker in the pre-diagnosis examinations that is easier for the clinical analysis than currently used blood test, and is applicable to large-scale epidemiological surveys of the probability of hepatitis B.
Gazarian
K G
KG
Department of Molecular Biology and Biotechnology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de México, México D. F., México. karlen@servidor.unam.mx
Gening
L V
LV
Gazarian
T G
TG
D019883:Alkyl and Aryl Transferases / Q000378:metabolism; D015415:Biomarkers / Q000652:urine; D006509:Hepatitis B / Q000652:urine*; D006714:Homoserine / Q000096:biosynthesis / Q000652:urine*; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008715:Methionine / Q000378:metabolism*; D008954:Models, Biological; D012436:S-Adenosylmethionine / Q000378:metabolism
D015415:Biomarkers; D006714:Homoserine; D012436:S-Adenosylmethionine; D008715:Methionine; D019883:Alkyl and Aryl Transferases; C019610:adenosylmethionine cyclotransferase; D006867:Hydrolases; C019614:adenosylmethionine hydrolase