title: N-(pyrimidin-4-yl) and N-(pyridin-2-yl) phenylalanine derivatives as VLA-4 integrin antagonists.
abstract: The SAR studies to optimise both potency and rate of clearance in the rat for a series of pyrimidine and pyridine based VLA-4 antagonists are described.
authors.affiliation: Celltech R&D Ltd, 216 Bath Road, SL1 4EN, Slough, UK. john.porter@celltechgroup.com
authors.forename: John R
authors.initials: JR
authors.lastname: Porter
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Archibald
authors.forename: Julien A
authors.initials: JA
authors.lastname: Brown
authors.forename: Kirstie
authors.initials: K
authors.lastname: Childs
authors.forename: David
authors.initials: D
authors.lastname: Critchley
authors.forename: John C
authors.initials: JC
authors.lastname: Head
authors.forename: Brian
authors.initials: B
authors.lastname: Hutchinson
authors.forename: Ted A H
authors.initials: TA
authors.lastname: Parton
authors.forename: Martyn K
authors.initials: MK
authors.lastname: Robinson
authors.forename: Anthony
authors.initials: A
authors.lastname: Shock
authors.forename: Graham J
authors.initials: GJ
authors.lastname: Warrellow
authors.forename: Alex
authors.initials: A
authors.lastname: Zomaya
mesh_terms: D039041:Integrin alpha4beta1 / Q000037:antagonists & inhibitors*; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D039041:Integrin alpha4beta1; C468809:N-(pyridin-2-yl) phenylalanine; C468810:N-(pyrimidin-4-yl) phenylalanine; D011725:Pyridines; D011743:Pyrimidines; D010649:Phenylalanine