Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis.
Interleukin-10 (IL-10) secretion affects the inducibility of experimental autoimmune encephalomyelitis and the outcome of multiple sclerosis (MS). Here, we report that a G to A polymorphism in the IL-10 promoter at position -2849 is significantly associated with low IL-10 production. The frequency of this polymorphism is lower among patients with primary progressive compared with patients with relapse-onset MS and control persons.
de Jong
Brigit A
BA
Department of Clinical Epidemiology, University of Glasgow, Scotland, United Kingdom.
Westendorp
Rudi G J
RG
Eskdale
Joyce
J
Uitdehaag
Bernard M J
BM
Huizinga
Tom W J
TW
D000328:Adult; D004198:Disease Susceptibility; D005260:Female; D015802:HLA-DR2 Antigen / Q000276:immunology; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000235:genetics* / Q000276:immunology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic
D015802:HLA-DR2 Antigen; D016753:Interleukin-10