Male germ cell specification and differentiation.
Understanding the mechanisms by which the germline is induced and maintained should lead to a broader understanding of the means by which pluripotency is acquired and maintained. In this review, two major aspects of male germ cell development are discussed: underlying mechanisms for induction and maintenance of primordial germ cells and the basic signaling pathways that determine spermatogonial cell fate.
Zhao
Guang Quan
GQ
Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical School, Dallas, TX 75390, USA.
Garbers
David L
DL
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D002454:Cell Differentiation; D002455:Cell Division; D002470:Cell Survival; D004330:Drosophila; D008297:Male; D051379:Mice; D015398:Signal Transduction; D013091:Spermatogenesis / Q000502:physiology*; D013093:Spermatogonia / Q000166:cytology; D013094:Spermatozoa / Q000166:cytology*; D013234:Stem Cells / Q000166:cytology
D019485:Bone Morphogenetic Proteins