title: MAb17-1A and cytokines for the treatment of patients with colorectal carcinoma.
abstract: CO17-1A/GA73-3/EpCam/KSA is a cellular adhesion molecule expressed on the majority of tumor cells in most patients with colorectal carcinoma. One of the first mouse monoclonal antibodies (MAbs) for therapeutic use was produced against this particular tumor associated antigen (MAb17-1A). MAb17-1A has served as a model for the development of antibody therapy. It exerts therapeutic effects through antibody dependent cellular cytotoxicity (ADCC), induction of an idiotypic network cascade and maybe also by complement activation. Addition of cytokines that augment these functions, mainly granulocyte macrophage-cerebrospinal fluid (GM-CSF), seemed to improve the clinical efficacy as well as chemotherapeutic agents (5-Fu). In advanced disease the clinical effect is, however, modest while the most beneficial clinical situation seems to be the adjuvant setting. Twenty years have passed since the EpCam antigen was identified as a target structure for immunotherapy, but still we do not know how to optimally use this target. The antigen might, however, be a rewarding structure to utilize for therapy. Preclinical and clinical trials are ongoing aimed at improving passive and active immunotherapy using CO17-1A/EpCam as a target antigen in colorectal carcinoma.
authors.affiliation: Department of Oncology (Radiumhemmet), Division of Oncologic Biotherapy, CancerCentrumKarolinska, Karolinska Hospital, Stockholm, Sweden.
authors.forename: Jan-Erik
authors.initials: JE
authors.lastname: Frödin
authors.forename: Jan
authors.initials: J
authors.lastname: Fagerberg
authors.forename: Anna-Lena
authors.initials: AL
authors.lastname: Hjelm Skog
authors.forename: Maria
authors.initials: M
authors.lastname: Liljefors
authors.forename: Peter
authors.initials: P
authors.lastname: Ragnhammar
authors.forename: Håkan
authors.initials: H
authors.lastname: Mellstedt
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D000951:Antigens, Neoplasm / Q000276:immunology; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000276:immunology / Q000628:therapy*; D016207:Cytokines / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D007376:Interleukin-2 / Q000627:therapeutic use; D051379:Mice
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D016207:Cytokines; D016898:Interferon-alpha; D007376:Interleukin-2; C050928:carcinoma-associated antigen 17-1A; C400149:Edrecolomab; D016178:Granulocyte-Macrophage Colony-Stimulating Factor