BINOL-catalyzed highly enantioselective terminal alkyne additions to aromatic aldehydes.
[reaction: see text] The readily available BINOL ligand in combination with Ti(O(i)Pr)(4) was found to catalyze the highly enantioselective reaction (92-98% ee) of terminal alkynes with aromatic aldehydes that contain a variety of substituents and substitution patterns. After the preparation of the zinc acetylide reagent, the catalytic asymmetric addition to aldehydes proceeded at room temperature with excellent stereocontrol. This simple catalyst system is practical for the asymmetric synthesis of chiral propargylic alcohols.
Moore
David
D
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, USA.
Pu
Lin
L
D001384:Azetidines / Q000138:chemical synthesis*; D002384:Catalysis; D005612:Freeze Drying; D006900:Hydroxylation; D010880:Piperidines / Q000138:chemical synthesis*; D020578:Sphingomonas / Q000378:metabolism*; D013237:Stereoisomerism
D001384:Azetidines; D010880:Piperidines