Pain--from periphery to brain.
Pain is not simply due to the activation of peripheral nociceptors but to multiple factors. Part of the article is a review of scientific work on such factors at the different levels of the peripheral and central nervous system, with particular reference to possible new therapy strategies. A second part describes some aspects of clinical assessment of persistent pain conditions, such as differential diagnostics between musculoskeletal nociceptive and neurogenic pain, between referred pain from a musculoskeletal focus and projected neurogenic pain, and between psychogenic pain and pain with a somatic cause.
Lundeberg
T
T
Section of Rehabilitation Medicine, Department of Public Health Sciences, Karolinska Institutet/Hospital, SE-17176, Stockholm, Sweden.
Ekholm
Jan
J
D000344:Afferent Pathways; D001921:Brain / Q000503:physiopathology*; D003863:Depression / Q000209:etiology; D006801:Humans; D009619:Nociceptors / Q000503:physiopathology*; D010146:Pain / Q000209:etiology* / Q000523:psychology; D010147:Pain Measurement; D010525:Peripheral Nerves / Q000503:physiopathology*; D013116:Spinal Cord / Q000503:physiopathology