9-[(Hydroxymethyl)phenyl]adenines: new aryladenine substrates of adenosine deaminase.
New phenyl adenine compounds 5-7 were synthesized as analogues of adenosine and studied for their adenosine deaminase (ADA) substrate activity. The 9-[(o-hydroxymethyl)phenyl]methyl]adenine 5 and 9-[(m-hydroxymethyl)phenyl]adenine 7 were deaminated by ADA, and 9-[(o-hydroxyethyl)phenyl]adenine 6 was not deaminated up to 7 days. The ADA substrates 5 and 7 were deaminated quantitatively to their inosine analogues in 10 and 6h, respectively.
Brakta
Mohamed
M
College of Pharmacy, Xavier University of Louisiana, New Orleans 70125, USA.
Murthy
Devangachinta
D
Ellis
L'Ouverture
L
Phadtare
Shashikant
S
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D002855:Chromatography, Thin Layer; D003641:Deamination / Q000187:drug effects; D007288:Inosine / Q000031:analogs & derivatives / Q000378:metabolism; D007422:Intestines / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D011687:Purines / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
D011687:Purines; D007288:Inosine; D000243:Adenosine Deaminase; D000241:Adenosine; C030985:purine