title: Mapping the oculomotor system: the power of transneuronal labelling with rabies virus.
abstract: Neuronal networks underlying and related to horizontal eye movements were visualized by retrograde transneuronal tracing with rabies virus from the left medial rectus muscle in guinea pigs. Time-sequenced labelling revealed distinct circuitries involved in particular oculomotor functions, i.e. vestibulo-ocular reflex and saccade generation (brainstem circuitry), adaptive plasticity (cerebellar modules) and possibly motivation and navigation (limbic, hippocampal and cortical structures). Our results provide a first comprehensive road map of the oculomotor system that is unsurpassed by any previous tracing study. We report a number of unexpected findings that illustrate a much vaster and more complicated network for the control of the relatively simple horizontal eye movements than had been envisioned previously.
authors.affiliation: Laboratoire de Physiologie de la Perception et de l'Action, CNRS-Collège de France, Paris, France.
authors.forename: Werner
authors.initials: W
authors.lastname: Graf
authors.forename: Nicolaas
authors.initials: N
authors.lastname: Gerrits
authors.forename: Najiya
authors.initials: N
authors.lastname: Yatim-Dhiba
authors.forename: Gabriella
authors.initials: G
authors.lastname: Ugolini
mesh_terms: D000818:Animals; D001370:Axonal Transport / Q000502:physiology; D001921:Brain / Q000166:cytology* / Q000502:physiology; D001931:Brain Mapping / Q000379:methods*; D005133:Eye Movements / Q000502:physiology*; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008297:Male; D009415:Nerve Net / Q000166:cytology* / Q000502:physiology / Q000821:virology; D009434:Neural Pathways / Q000166:cytology* / Q000502:physiology / Q000821:virology; D009474:Neurons / Q000166:cytology* / Q000502:physiology / Q000821:virology; D009801:Oculomotor Muscles / Q000294:innervation* / Q000502:physiology / Q000821:virology; D011820:Rabies virus / Q000378:metabolism*; D013569:Synapses / Q000502:physiology / Q000648:ultrastructure / Q000821:virology; D009435:Synaptic Transmission / Q000502:physiology