title: [Severe pneumococcal meningitis and ceftriaxone allergy].
abstract: We report the case of a 51-year-old man with an allergy to amoxicillin/acid clavulanique who presented with Streptococcus pneumoniae meningitis. Initial treatment consisted of an association of antibiotics including ceftriaxone. Six days after treatment was initiated the patient developed skin reaction and the diagnosis of allergy to ceftriaxone was established by the dosage of specific IgE. Typically Streptococcus pneumoniae meningitis is treated with vancomycin and a third-generation cephalosporin. This association had to be modified because cross allergy to cephalosporins could have developed in this patient who had previously reacted to penicillins.
authors.affiliation: Département d'anesthésie-réanimation, hôpital d'instruction des armées du Val de Grâce, 74, boulevard de Port Royal, 75005, Paris, France. schmart@free.fr
authors.forename: S
authors.initials: S
authors.lastname: Mérat
authors.forename: J M
authors.initials: JM
authors.lastname: Rousseau
authors.forename: M
authors.initials: M
authors.lastname: Lerecouvreux
authors.forename: I
authors.initials: I
authors.lastname: Vincenti-Rouquette
authors.forename: L
authors.initials: L
authors.lastname: Brinquin
mesh_terms: D002443:Ceftriaxone / Q000009:adverse effects*; D002511:Cephalosporins / Q000009:adverse effects*; D006801:Humans; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy*; D008875:Middle Aged; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy*; D013296:Streptococcus pneumoniae
chemical_list: D002511:Cephalosporins; D002443:Ceftriaxone