title: Anti-lipid-peroxidative principles from Tournefortia sarmentosa.
abstract: Using the inhibition of Cu(2+)-induced low-density-lipoprotein (LDL) peroxidation to direct fractionation, four new benzenoids, tournefolal (1), tournefolic acids A (2) and B (3), and B ethyl ester (4), together with salvianolic acid A (5), isosalvianolic acid C (6), lithospermic acid (7), salvianolic acid F (8), and rosmarinic acid (9), were isolated from the stems of Tournefortia sarmentosa. The structures of the new compounds 1-4 were elucidated on the basis of spectral and chemical methods. Furthermore, the anti-LDL-peroxidative activity of the isolated compounds was determined. All isolated compounds exhibited more potent activity than probucol except for salvianolic acid F (8).
authors.affiliation: National Research Institute of Chinese Medicine, Taipei 112, Taiwan. yllin@cma23.nricm.edu.tw
authors.forename: Yun-Lian
authors.initials: YL
authors.lastname: Lin
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Chang
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
authors.forename: Ming-Shi
authors.initials: MS
authors.lastname: Shiao
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001555:Benzene Derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028082:Boraginaceae / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D003300:Copper / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000378:metabolism*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D010545:Peroxides / Q000378:metabolism; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan
chemical_list: D000975:Antioxidants; D001555:Benzene Derivatives; D000960:Hypolipidemic Agents; D008077:Lipoproteins, LDL; D010545:Peroxides; D003300:Copper