Association study of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease.
Serotonergic (5-hydroxytryptamine; 5-HT) transmission has been implicated in the pathogenesis of Alzheimer's disease (AD). A coding single nucleotide polymorphism 267 (C/T) in the 5-HT(6) receptor gene was previously reported as a susceptibility factor for AD. An extensive replication study was performed using our data set including sporadic and familial cases. No significant association between the 5-HT(6) receptor gene and AD was obtained with or without the stratification of apolipoprotein E epsilon 4 status. Our result suggests that the 267C allele of the 5-HT(6) receptor gene may not be a genetic risk factor for AD.
Orlacchio
Antonio
A
Laboratorio di Neurogenetica, I.R.C.C.S. Santa Lucia, Via Ardeatina 354, 00179, Rome, Italy. a.orlacchio@hsantalucia.it
Kawarai
Toshitaka
T
Paciotti
Eleonora
E
Stefani
Alessandro
A
Orlacchio
Aldo
A
Sorbi
Sandro
S
St George-Hyslop
Peter H
PH
Bernardi
Giorgio
G
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000097:blood; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D011985:Receptors, Serotonin / Q000235:genetics*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D011985:Receptors, Serotonin; C097216:serotonin 6 receptor