title: [A case of breast cancer with multiple bone metastases that responded remarkably to doxifluridine (5'-DFUR), cyclophosphamide (CPA), medroxyprogesterone acetate (MPA) and pamidronate disodium therapy].
abstract: A 49-year-old female underwent bilateral breast preserving surgery for heterochronic breast cancers. She later developed a sternal metastasis and was recommended for intravenous chemotherapy. However, she refused such an intensive therapy and opted for immunotherapy. Afterward, she came to our hospital because of spinal metastases with back pain. She was treated with oral administration of 5'-DFUR and MPA 1,200 mg/day for 3 weeks, respectively, CPA 100 mg/day for 2 weeks, and pamidronate disodium 30 mg intravenously every 4 weeks. This combined chemotherapy relieved her pain after one course. After 5 courses, tumor markers were reduced to the normal range. After 14 courses, bone X-P revealed that the osteolytic bone showed sclerotic changes and bone scintigraphy showed a complete remission (CR). The adverse effects were not remarkable. This regimen is possible on an outpatient basis, and it may play an important role from the standpoint of treatment effectiveness and the quality of life of the patient.
authors.affiliation: 3rd Dept. of Surgery, Tokyo Medical University.
authors.forename: Mikihiro
authors.initials: M
authors.lastname: Kusama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kaise
authors.forename: Syun
authors.initials: S
authors.lastname: Nakayama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ota
authors.forename: Tatuya
authors.initials: T
authors.lastname: Aoki
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Koyanagi
authors.forename: Takenori
authors.initials: T
authors.lastname: Misaka
authors.forename: Tadaharu
authors.initials: T
authors.lastname: Matunaga
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D003520:Cyclophosphamide / Q000008:administration & dosage; D004164:Diphosphonates / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage; D008875:Middle Aged; D000077268:Pamidronate; D011788:Quality of Life
chemical_list: D004164:Diphosphonates; D005467:Floxuridine; D003520:Cyclophosphamide; D017258:Medroxyprogesterone Acetate; D000077268:Pamidronate; C025034:doxifluridine