Postnatal maternal deprivation aggravates experimental autoimmune encephalomyelitis in adult Lewis rats: reversal by chronic imipramine treatment.
Stressful experiences can modulate multiple sclerosis, but stress protection is currently not considered a treatment option. Here, we show that maternal deprivation, an adverse stress experience in infancy, increases emotionality in behavioral tests of adult female Lewis rats and concomitantly causes a more severe course of experimental autoimmune encephalomyelitis. Treatment of these effects in adulthood by chronic antidepressants (imipramine) reversed the behavioral symptoms and attenuated the course of the encephalomyelitis in deprived rats. Increased IL-4 plasma levels accompanied the protective-like effects of antidepressants. In contrast, attempts to prevent these effects in infancy by tactile stimulation aggravated the encephalomyelitis, possibly by decreasing corticosterone and increasing IFN-gamma levels during the disease. This indicates that antidepressants exert protective effects in an animal model of multiple sclerosis, and suggests that drugs modifying stress responsiveness may have a potential role as adjuvant treatment of the disease.
Stephan
Michael
M
Department of Functional and Applied Anatomy, OE4120, Medical School of Hannover, Carl-Neuberg Street 1, Germany.
Straub
Rainer H
RH
Breivik
Torbjørn
T
Pabst
Reinhard
R
von Hörsten
Stephan
S
D000818:Animals; D000831:Animals, Newborn; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D007099:Imipramine / Q000494:pharmacology*; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008426:Maternal Deprivation; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors
D000929:Antidepressive Agents, Tricyclic; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma; D007099:Imipramine; D003345:Corticosterone