title: Pseudoexfoliation and sensorineural hearing loss.
abstract: OBJECTIVE
  There is increasing evidence that pseudoexfoliation (PXF) not only affects ocular anterior segment structures, but may also be a systemic disease. This study was undertaken to assess the relationship between PXF and sensorineural hearing loss.
  
  
  METHODS
  Patients with PXF were identified from hospital records and underwent complete ocular examination. The sum of pure-tone hearing thresholds measured at 1, 2 and 3 kHz (HTL1,2,3) in each ear was compared with the ISO 7029 standard sex-matched, median age-associated hearing loss summed over the same frequencies (AAHL1,2,3). The proportion of ears with thresholds higher than the ISO 7029 median AAHL1,2,3 on the same side as eyes without PXF was compared with the proportion of ears ipsilateral to eyes with PXF but without glaucoma and similarly the proportion of ears on the same side as eyes with PXF and glaucoma.
  
  
  RESULTS
  In total, 69 patients were studied, of whom 39 were male (56.5%). The mean age of the male patients was 75.8 years, while that of the female group was 75.1 years. All patients had PXF affecting at least one eye. Overall 101 ears (73.7%) had a higher HTL1,2,3 than the ISO 7029 median AAHL1,2,3 which included 56 ears of 78 in the male group (71.8%) and 45 ears of 59 in the female group (76.3%). There was no significant difference between the proportion of ears with HTL1,2,3 higher than the ISO 7029 median AAHL1,2,3 on the same side as eyes without PXF, with PXF but not glaucoma and with PXF and glaucoma, in either the male or female groups.
  
  
  CONCLUSIONS
  A large proportion of patients with PXF have sensorineural hearing loss in comparison to age-matched controls, regardless of whether or not there is associated glaucoma. This finding supports the theory that PXF may be a systemic condition.
authors.affiliation: Institute of Ophthalmology, University College Dublin, Mater Misericordiae Hospital, Dublin, Ireland. cahil005@mc.duke.edu
authors.forename: M
authors.initials: M
authors.lastname: Cahill
authors.forename: A
authors.initials: A
authors.lastname: Early
authors.forename: S
authors.initials: S
authors.lastname: Stack
authors.forename: A W
authors.initials: AW
authors.lastname: Blayney
authors.forename: P
authors.initials: P
authors.lastname: Eustace
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001301:Audiometry, Pure-Tone; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D017889:Exfoliation Syndrome / Q000150:complications*; D005260:Female; D005901:Glaucoma / Q000150:complications; D006319:Hearing Loss, Sensorineural / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged