Pathways defective in the human premature aging disease Werner syndrome.
Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and role of this protein is discussed in the light of how it functions in the aging process.
Bohr
Vilhelm A
VA
Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA. vbohr@nih.gov
Brosh
Robert M
RM
von Kobbe
Cayetano
C
Opresko
Patricia
P
Karmakar
Parimal
P
D000375:Aging / Q000502:physiology; D006801:Humans; D011485:Protein Binding; D014898:Werner Syndrome / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology