Chicken anemia virus and infectious bursal disease virus interfere with transcription of chicken IFN-alpha and IFN-gamma mRNA.
Chicken anemia virus (CAV) and infectious bursal disease virus (IBDV) are the two most important viruses that cause immunosuppression in commercial chickens. Because inapparent, subclinical infections by these viruses cause immunosuppression, there is need for assessment of the immune status of chickens. Interference with induction of transcription for chicken interferon-alpha (ChIFN-alpha) and ChIFN-gamma was noted after subclinical infections with either CAV or IBDV. Because the immunosuppressive viruses of chickens may interfere with transcription for ChIFN-alpha and ChIFN-gamma, we propose using this interference to assess the immune status of chickens.
Ragland
William L
WL
Institut Rudder Bosković, Division of Molecular Medicine, 10000 Zagreb, Croatia. wrag@rudjer.irb.hr
Novak
Renata
R
El-Attrache
John
J
Savić
Vladimir
V
Ester
Katja
K
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D017727:Chicken anemia virus / Q000276:immunology / Q000472:pathogenicity*; D002645:Chickens / Q000235:genetics / Q000276:immunology* / Q000821:virology; D007243:Infectious bursal disease virus / Q000276:immunology / Q000472:pathogenicity*; D016898:Interferon-alpha / Q000096:biosynthesis* / Q000235:genetics; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000235:genetics; D007700:Kinetics; D012333:RNA, Messenger / Q000096:biosynthesis; D014158:Transcription, Genetic
D000914:Antibodies, Viral; D016898:Interferon-alpha; D012333:RNA, Messenger; D007371:Interferon-gamma