title: Short-term diets enriched in stearic or palmitic acids do not alter plasma lipids, platelet aggregation or platelet activation status.
abstract: OBJECTIVE
  To determine whether healthy males who consumed increased amounts of dietary stearic acid compared with increased dietary palmitic acid through the consumption of commercially available foods, exhibited any changes in plasma lipids, platelet aggregation or platelet activation status.
  
  
  METHODS
  A randomised cross-over dietary intervention.
  
  
  METHODS
  Nine free-living healthy males consumed two experimental diets (stearic acid enriched, diet S, and palmitic acid enriched, diet P) for 3 weeks in a randomised cross-over design separated by a 3 week washout phase. The diets consisted of approximately 30% of energy as fat (30% of which was derived from the treatment diets) providing approximately 13 g/day as stearic acid and 17 g/day as palmitic acid on diet S and approximately 7 g/day as stearic acid and 22 g/day as palmitic acid on diet P. The dietary ratio of stearic to palmitic acids was 0.76 on diet S compared with 0.31 on diet P. Blood samples were collected on days 0 and 21 of each dietary period.
  
  
  RESULTS
  LDL cholesterol levels and platelet aggregation response to the agonist ADP were significantly decreased (P<0.025) in subjects on diet S compared with day 0. Apart from that, there were no significant changes in plasma lipids, platelet aggregation, mean platelet volume and platelet reactivity between diets. There were no significant changes in stearic or palmitic acid levels in plasma phospholipid or triacylglycerol. There was a significant difference in palmitic acid levels in platelet phospholipids between the two diets.
  
  
  CONCLUSIONS
  Use of commonly available foods led to a 27% increase in stearic acid (diet S) and a 19% increase in palmitic acid (diet P), on diets S and P respectively, and no significant differences between the two diets in plasma lipoprotein concentrations, platelet aggregation or platelet activation status.
authors.affiliation: Department of Food Science, RMIT University, Melbourne, Australia.
authors.forename: F D
authors.initials: FD
authors.lastname: Kelly
authors.forename: A J
authors.initials: AJ
authors.lastname: Sinclair
authors.forename: N J
authors.initials: NJ
authors.lastname: Mann
authors.forename: A H
authors.initials: AH
authors.lastname: Turner
authors.forename: F L
authors.initials: FL
authors.lastname: Raffin
authors.forename: M V
authors.initials: MV
authors.lastname: Blandford
authors.forename: M J
authors.initials: MJ
authors.lastname: Pike
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D018592:Cross-Over Studies; D005434:Flow Cytometry; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D019308:Palmitic Acid / Q000008:administration & dosage*; D015539:Platelet Activation / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D013229:Stearic Acids / Q000008:administration & dosage*
chemical_list: D008055:Lipids; D013229:Stearic Acids; D019308:Palmitic Acid; C031183:stearic acid