title: The 3A non-structural-protein coding region of the southern African SAT type isolates differs from that of other foot-and-mouth disease viruses.
abstract: The 3A non-structural protein of foot-and-mouth disease viruses is a relatively conserved protein comprising 153 amino acids. Recent studies have demonstrated correlation between mutations in the 3A non-structural-protein-coding region, including a 10-amino acid deletion, and attenuation of the viruses in cattle. Although the 3A coding region of several type A, O and C isolates has previously been described, nucleotide sequence data of the 3A coding region of the South African Types (SAT) 1, 2 and 3 viruses are limited. Therefore, the 3A non-structural-coding region of different SAT serotypes was determined, analysed and compared to that of European, South American and Asian isolates. The 3A regions of the SAT isolates investigated differed markedly from that of types A, O, C and Asia-1, but were similar within the group.
authors.affiliation: Onderstepoort Veterinary Institute, Exotic Diseases Division, South Africa.
authors.forename: L E
authors.initials: LE
authors.lastname: Heat
authors.forename: H G
authors.initials: HG
authors.lastname: Van Rensburg
authors.forename: W
authors.initials: W
authors.lastname: Vosloo
authors.forename: L H
authors.initials: LH
authors.lastname: Nel
mesh_terms: D017954:Africa South of the Sahara; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002020:Buffaloes; D002417:Cattle; D029544:Foot-and-Mouth Disease Virus / Q000145:classification* / Q000235:genetics; D014644:Genetic Variation; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000662:veterinary; D016415:Sequence Alignment / Q000662:veterinary; D012703:Serotyping / Q000662:veterinary; D013552:Swine; D017361:Viral Nonstructural Proteins / Q000737:chemistry / Q000235:genetics*
chemical_list: D017361:Viral Nonstructural Proteins