Evaluation of pefloxacin activity against recent clinical isolates.
The in-vitro antibacterial activity of pefloxacin, a new quinolone carboxylic acid, was tested against 1140 bacterial strains, recently clinically isolated, by measuring the minimum inhibitory concentrations. Comparisons were made with other quinolones (enoxacin, norfloxacin, flumekin, oxolinic acid, pipemidic acid) and other drugs (piperacillin, cefotaxime, ceftazidime, gentamicin, tobramycin, amikacin) widely used for the treatment of bacterial infections. Pefloxacin was very active against the tested species and was the most active drug against all the bacterial strains, with a geometric mean of MICs, a MIC 50 and MIC 90 of 0.27, 0.12 and 4 microg/ml respectively.
Lembo
M
M
Department of Cellular and Molecular Biology and Pathology, II Medical School, Faculty of Pharmacy, University of Naples, Italy.
Covelli
B
B
Nani
E
E
Lavitola
A
A
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015366:Pefloxacin / Q000494:pharmacology*
D000890:Anti-Infective Agents; D015366:Pefloxacin