title: Percutaneous fine-needle aspiration cytology in the diagnosis and management of liver tumours.
abstract: BACKGROUND
  The aim of the study was to investigate the value of percutaneous fine-needle aspiration cytology (FNAC) in the diagnosis and management of liver tumours.
  
  
  METHODS
  FNAC followed by histopathological examination was carried out in 216 patients with suspected liver tumours. The final diagnosis was primary liver cancer in 106, colorectal metastases in 51, non-colorectal metastases in 46, benign tumour in nine and no tumour in four patients.
  
  
  RESULTS
  Cytology resulted in correct classification of the lesion as benign or malignant in 87 per cent of patients, correct discrimination between primary and secondary malignancy in half of the patients, and a correct diagnosis of tumour type in one-third of patients. The tumour was erroneously classified as benign or malignant in 22 patients (11 per cent) and four patients (2 per cent) respectively. When FNAC showed malignancy, the predictive value was 98 per cent, whereas the predictive value was 27 per cent when it did not. FNAC guided investigations and treatment in one-quarter of patients. Implantation metastases were recorded in seven patients (3 per cent), including five (10 per cent) of 51 patients with colorectal liver metastases, and caused major local problems and death in four patients.
  
  
  CONCLUSIONS
  FNAC was valuable in about a quarter of patients with liver tumour. The risks of implantation metastases and a false-negative finding do not justify its use in candidates for curative therapy of liver tumours.
authors.affiliation: Department of Surgery, University of Lund, SE-22185 Lund, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Ohlsson
authors.forename: J
authors.initials: J
authors.lastname: Nilsson
authors.forename: U
authors.initials: U
authors.lastname: Stenram
authors.forename: M
authors.initials: M
authors.lastname: Akerman
authors.forename: K-G
authors.initials: KG
authors.lastname: Tranberg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000009:adverse effects / Q000379:methods* / Q000592:standards; D015179:Colorectal Neoplasms; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010353:Patient Education as Topic; D012189:Retrospective Studies; D012680:Sensitivity and Specificity