[Effect of nonsteroidal estrogen-like substances on aromatase activity].
The effects in vitro of DDT, DDE and genistein on rat uterine purified aromatase activity were studied. It was established that all these compounds were competitive aromatase inhibitor. In the studies in vivo DDT and genistein decrease the rat ovarian and rat uterine aromatase activity. They were identified to decrease the quantity of the aromatase in these organs by inhibiting the expression of corresponding genes.
Iasinskaia
I M
IM
Mechnikov Odessa National University. inna@farlep.net
Rozanov
A Ia
AIa
D000818:Animals; D001141:Aromatase / Q000378:metabolism; D047072:Aromatase Inhibitors; D003634:DDT / Q000494:pharmacology*; D003633:Dichlorodiphenyl Dichloroethylene / Q000494:pharmacology*; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology*; D005260:Female; D019833:Genistein / Q000494:pharmacology; D010053:Ovary / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000187:drug effects / Q000201:enzymology
D047072:Aromatase Inhibitors; D004968:Estrogens, Non-Steroidal; D003633:Dichlorodiphenyl Dichloroethylene; D003634:DDT; D019833:Genistein; D001141:Aromatase