title: Total synthesis of ionomycin using ring-opening strategies.
abstract: [structure: see text] The total synthesis of the polyether antibiotic ionomycin, a calcium ionophore, is described. The synthesis demonstrates the utility of ring-opening methodologies as applied to the synthesis of polypropionate and deoxypolypropionate subunits, which are found in two of the four fragments in the synthesis.
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ontario M5S 3H6, Canada. mlautens@chem.utoronto.ca
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
authors.forename: John T
authors.initials: JT
authors.lastname: Colucci
authors.forename: Sheldon
authors.initials: S
authors.lastname: Hiebert
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Smith
authors.forename: Giliane
authors.initials: G
authors.lastname: Bouchain
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002118:Calcium / Q000737:chemistry; D006900:Hydroxylation; D007202:Indicators and Reagents; D015759:Ionomycin / Q000138:chemical synthesis*; D010126:Ozone / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D015759:Ionomycin; D010126:Ozone; D002118:Calcium