Glucocorticoids in adipocytes stimulate visceral obesity.
The enzyme 11beta hydroxysteroid dehydrogenase-1 (11beta HSD-1) regenerates active glucocorticoids from inactive glucocorticoids. When over-expressed in adipose tissue, this enzyme was shown to promote increased visceral adipose levels. The resulting visceral obesity was associated with insulin-resistant diabetes and dyslipidemia. Increased adipocyte 11beta HSD-1 is a possible cause of visceral obesity in humans.
Wolf
George
G
Department of Nutritional Sciences and Toxicology, University of California, Berkeley 94720-3104, USA.
D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1; D000005:Abdomen / Q000033:anatomy & histology; D017667:Adipocytes / Q000166:cytology / Q000378:metabolism*; D000273:Adipose Tissue / Q000201:enzymology* / Q000378:metabolism; D001823:Body Composition; D005938:Glucocorticoids / Q000378:metabolism*; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000737:chemistry / Q000378:metabolism*; D024821:Metabolic Syndrome; D009765:Obesity / Q000201:enzymology* / Q000378:metabolism; D013329:Structure-Activity Relationship; D014781:Viscera; D015430:Weight Gain
D005938:Glucocorticoids; D006913:Hydroxysteroid Dehydrogenases; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1; C468386:HSD11B1 protein, human