title: Peptic ulceration in general practice in England and Wales 1994-98: period prevalence and drug management.
abstract: BACKGROUND
  Little is known about the burden of peptic ulcer in the community.
  
  
  OBJECTIVE
  To examine recent time trends in the period prevalence of peptic ulceration and its drug management, in England and Wales.
  
  
  METHODS
  For each year between 1994 and 1998, information on patients with a diagnosis of peptic ulceration was extracted from the General Practice Research Database.
  
  
  RESULTS
  The annual age-standardized period prevalence of peptic ulceration decreased from 3.3/1000 in 1994 to 1.5/1000 in 1998 for men, and from 1.8/1000 to 0.9/1000 for women. This decline was more evident among younger people, and among males registered with practices located in the most deprived electoral wards compared to those located in the least deprived. The proportion of patients receiving H2 receptor antagonists declined from 68% in 1994 to 41% in 1998. In contrast, the proportion prescribed proton pump inhibitors rose from 46% to 66%.
  
  
  CONCLUSIONS
  Over a 5-year period, the period prevalence of peptic ulceration has decreased markedly, especially among younger people and those from more deprived areas.
authors.affiliation: Department of Gastroenterology, St George's Hospital, Blackshaw Road, London SW17 0QT, UK. jykang@sghms.ac.uk
authors.forename: J-Y
authors.initials: JY
authors.lastname: Kang
authors.forename: A
authors.initials: A
authors.lastname: Tinto
authors.forename: J
authors.initials: J
authors.lastname: Higham
authors.forename: A
authors.initials: A
authors.lastname: Majeed
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D017281:Cost of Illness; D016208:Databases, Factual; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000453:epidemiology*; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D015995:Prevalence; D054328:Proton Pump Inhibitors; D012737:Sex Factors; D014852:Wales / Q000453:epidemiology
chemical_list: D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors