title: Timing of G-CSF administration based on the circadian rhythm in patients with ovarian cancer.
abstract: The aim of this study was to determine the relationship between the timing of granulocyte colony-stimulating factor (G-CSF) administration and its efficacy in patients with chemotherapy-induced granulocytopenia. Twenty patients in whom chemotherapy-induced leukopenia developed after the first course were enrolled in this prospective study. Subjects were randomly divided in two groups according to G-CSF injection time as follows: at 7:00 am and 7:00 pm. Before the G-CSF injection, the plasma G-CSF level for all patients was significantly lower at 7:00 am than that at 7:00 pm. After the injection, plasma G-CSF level did not differ between the two groups. The nadir of the leukocyte was 2,554 +/- 379/mm3 (granulocyte 1,530 +/- 689) for the group injected at 7:00 am, and 2,300 +/- 426/mm3 (granulocyte 1,203 +/- 848) for the group injected at 7:00 pm. The duration of leukocytes less than 2,000/mm3 and granulocytes less than 1,000/mm3 were 2.8 +/- 1.8 days and 3.2 +/- 1.8 days, respectively. Those differences were not significant. The present study showed the circadian rhythm of G-CSF levels in patients with ovarian cancer with chemotherapy-induced granulocytopenia, but there was no remarkable difference depending on administration time.
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Sato
authors.forename: Junzo
authors.initials: J
authors.lastname: Kigawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Irie
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Itamochi
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Kanamori
authors.forename: Shunji
authors.initials: S
authors.lastname: Kamazawa
authors.forename: Ryoji
authors.initials: R
authors.lastname: Akeshima
authors.forename: Naoki
authors.initials: N
authors.lastname: Terakawa
mesh_terms: D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced / Q000517:prevention & control*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002940:Circadian Rhythm; D004334:Drug Administration Schedule; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D011446:Prospective Studies
chemical_list: D016179:Granulocyte Colony-Stimulating Factor