[Hepatoprotective effect of plant preparations].
The hepatoprotector activity of original compositions of plant origin, containing beet and carrot juices, decoction of dog rose fruits, and extracts of corn silk, peppermint leaves, and common horsetail herbs was studied on an acute hepatitis model induced by tetrachloromethane. An analysis of the data on the hepatocyte cytolysis, cholestasis, lipid peroxidation, and antioxidant system of blood serum showed that the preparations possess membranoprotector and antioxidant properties. This was manifested by a decrease in the activity of alanine aminotransferase and in the levels of total bilirubin and the final (malonaldehyde) and intermediate (diene conjugates) lipid peroxidation products, and by the absence of decline in the level of endogenous alpha-tocopherol and in the activity of glutathione-dependent enzymes.
Katikova
O Iu
OIu
Department of Experimental and Clinical Pharmacology, Biochemistry, and General Chemistry, Ul'yanovsk State University, ul. K. Libknekhta 1, Ul'yanovsk, 432063 Russia.
Kostin
Ia V
IaV
Tishkin
V S
VS
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D028321:Plant Preparations; D020011:Protective Agents