title: [Acanthamoeba keratitis, a possible dibromo propamidine isethionate resistance].
abstract: OBJECTIVE
  To point out that acanthamoeba keratitis can show therapeutical resistance to dibrome propamidine isethionate (Brolene). We have a late diagnosis case of corneal melting on a bilateral acanthamoeba keratitis.
  
  
  CONCLUSIONS
  We performed corneal graft in one eye and found histopathological evidence of acanthamoeba. There was relapse in the graft in spite of Brolene treatment and good results when we changed to polyhidroxy methylbigunide (PHMB). In case of therapeutical Brolene resistance, PHMB can be an adequate alternative (Arch Soc Esp Oftalmol 2002; 77: 279-282).
authors.affiliation: Hospital Universitario Clínica Puerta de Hierro, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Vaquero Ruano
authors.forename: J L
authors.initials: JL
authors.lastname: Encinas Martín
authors.forename: S
authors.initials: S
authors.lastname: Ramón Y Cajal
authors.forename: C
authors.initials: C
authors.lastname: Cajigal Morales
mesh_terms: D015823:Acanthamoeba Keratitis / Q000188:drug therapy*; D000328:Adult; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D001550:Benzamidines / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D008297:Male
chemical_list: D000981:Antiprotozoal Agents; D001550:Benzamidines; C046651:propamidine isethionate