title: Subcutaneous abdominal adipose tissue lipolysis during exercise determined by arteriovenous measurements in older women.
abstract: OBJECTIVE
  To characterize the lipolytic response in the subcutaneous abdominal adipose tissue in older women to endurance exercise.
  
  
  METHODS
  Cross-sectional exercise study.
  
  
  METHODS
  Exercise laboratory, Copenhagen, Denmark.
  
  
  METHODS
  Seven healthy, older women (mean age +/- standard error = 75 +/- 2 years); weight: 67.8 +/- 4.9 kg; body fat: 40 +/- 3; maximal oxygen uptake (VO2max): 1.43 +/- 0.07 L.min 1).
  
  
  METHODS
  Body composition (dual energy x-ray absorptiometry (DEXA)), maximal oxygen uptake (VO2max, maximal cycling test), lipolytic response to exercise (arterial and adipose tissue venous catheterization at rest and during 60 minutes of continuous cycling at a load corresponding to 60 of VO2max), adipose tissue blood flow (ATBF) (133Xenon (133Xe) washout), oxygen consumption and respiratory exchange ratio during exercise (indirect calorimetry), whole blood glycerol, plasma nonesterified fatty acids (NEFA), lactate, glucose, epinephrine, norepinephrine, insulin, serum growth hormone, and hematocrit.
  
  
  RESULTS
  Glycerol and NEFA mobilization rates increased by 250 and 180, respectively, from rest to exercise. This was achieved primarily by an increase in veno-arterial differences, because ATBF did not increase significantly. NEFA:glycerol mobilization ratio was about two at rest and remained at that level during exercise, indicating significant local reesterification in both conditions. After an initial decrease, arterial plasma NEFA concentration increased significantly, by 26, indicating that NEFA delivery exceeded muscle uptake.
  
  
  CONCLUSIONS
  Older women are capable of prompt and substantial increase in subcutaneous abdominal adipose tissue glycerol and NEFA mobilization rates in response to moderate acute endurance exercise. The lipolytic response matches skeletal muscle NEFA uptake, and decreased ability to mobilize fat during exercise is therefore not likely to cause increased fat mass with advancing age.
authors.affiliation: Sports Medicine Research Unit, Bispebjerg Hospital, Copenhagen, Denmark. klange@dadlnet.dk
authors.forename: Kai Henrik Wiborg
authors.initials: KH
authors.lastname: Lange
authors.forename: Jeanne
authors.initials: J
authors.lastname: Lorentsen
authors.forename: Fredrik
authors.initials: F
authors.lastname: Isaksson
authors.forename: Lene
authors.initials: L
authors.lastname: Simonsen
authors.forename: Anders
authors.initials: A
authors.lastname: Juul
authors.forename: Niels Juel
authors.initials: NJ
authors.lastname: Christensen
authors.forename: Michael
authors.initials: M
authors.lastname: Kjaer
authors.forename: Jens
authors.initials: J
authors.lastname: Bülow
mesh_terms: D000005:Abdomen; D000273:Adipose Tissue / Q000098:blood supply / Q000378:metabolism*; D000368:Aged; D000704:Analysis of Variance; D001823:Body Composition; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005990:Glycerol / Q000097:blood; D006439:Hemodynamics; D006801:Humans; D008066:Lipolysis / Q000502:physiology*; D009765:Obesity / Q000517:prevention & control*; D010101:Oxygen Consumption
chemical_list: D005230:Fatty Acids, Nonesterified; D005990:Glycerol