Serotonin and benzylamine oxidation by type A and type B MAO of rat brain in presence of organophosphate pesticides.
Organophosphate (OP) pesticides, monocrotophos (MCP), dichlorvos (DDVP) and phosphamidon significantly inhibit both MAO-A and MAO-B activities in rat brain mitochondria. The inhibition of MAO-A by MCP is reversible whereas the inhibition by DDVP and phosphamidon is irreversible. MAO-B is inhibited irreversibly by all these organophosphates suggesting that the mechanism of action of OP pesticides is through phosphorylation of serine residue present in active centre of MAO.
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Indian Institute of Chemical Biology, Jadavpur, Calcutta, India. iichbio@giasc101.vsnl.net.in
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D000818:Animals; D001596:Benzylamines / Q000378:metabolism*; D001921:Brain / Q000201:enzymology; D007306:Insecticides / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism*; D009943:Organophosphorus Compounds; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*
D001596:Benzylamines; D007306:Insecticides; D009943:Organophosphorus Compounds; D012701:Serotonin; C030796:benzylamine; D008995:Monoamine Oxidase