title: Hypercalcemia and acute renal failure caused by production of parathyroid hormone-related protein from renal cell carcinoma.
abstract: A 69-year-old male patient was diagnosed with right-sided renal cell carcinoma and humoral hypercalcemia of malignancy caused by an excessive production of parathyroid hormone-related protein. The hypercalcemia led to acute tubular necrosis, so the patient had to be put on hemodialysis. The renal failure was accompanied by hyponatremic encephalopathy. Rapid correction of the hyponatremia might have initiated central pontine myelinolysis.
authors.affiliation: Department of Urology, Keio University School of Medicine, Tokyo, Japan. camtmune@saitama-med.ac.jp
authors.forename: Munehisa
authors.initials: M
authors.lastname: Ueno
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohigashi
authors.forename: Jun
authors.initials: J
authors.lastname: Nakashima
authors.forename: Shoichi
authors.initials: S
authors.lastname: Nonaka
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Deguchi
authors.forename: Masaru
authors.initials: M
authors.lastname: Murai
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000378:metabolism*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007680:Kidney Neoplasms / Q000150:complications / Q000378:metabolism*; D008297:Male; D044162:Parathyroid Hormone-Related Protein; D014176:Protein Biosynthesis
chemical_list: C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein