Dicobalt octacarbonyl promoted rearrangement of 4-isoxazolines to acylaziridines: dramatic rate acceleration with very high substrate tolerance.
[reaction: see text] Dicobalt octacarbonyl [Co(2)(CO)(8)] in acetonitrile at 75 degrees C triggers the cleavage of the N-O bond of 4-isoxazolines (1) to bring about the valence rearrangement to 2-acylaziridines (2). The isoxazolines were stable at 75 degrees C in the absence of the cobalt complex.
Ishikawa
Teruhiko
T
Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Tsushima, Okayama, Japan 700-8530. sesaito@biotech.okayama-u.ac.jp
Kudoh
Takayuki
T
Yoshida
Juri
J
Yasuhara
Ayako
A
Manabe
Shinobu
S
Saito
Seiki
S