title: Dendritic cell-based immunoregulatory strategies.
abstract: Dendritic cells (DC) are special subsets of professional antigen-presenting cells that play a dual role in initiating and silencing acquired immune responses. Thus, it should be feasible to control the magnitude and direction of immune responses by experimental manipulation of DC function. We will provide an overview of the recent progress in the development of DC-based immunostimulatory and immunosuppressive strategies, which are potentially applicable to the treatment of cancer, allergy, autoimmune disease, allograft rejection and graft versus host disease.
authors.affiliation: Department of Dermatology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-6069, USA. hiroyuki.matsue@utsouthwestern.edu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Matsue
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kusuhara
authors.forename: Keiko
authors.initials: K
authors.lastname: Matsue
authors.forename: Akira
authors.initials: A
authors.lastname: Takashima
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D001698:Biomedical Engineering; D003713:Dendritic Cells / Q000276:immunology*; D015316:Genetic Therapy; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007114:Immunization / Q000379:methods; D007165:Immunosuppression Therapy / Q000379:methods; D007167:Immunotherapy / Q000379:methods*; D051379:Mice
chemical_list: D000951:Antigens, Neoplasm