title: Urinary acidification and distal renal tubular acidosis.
abstract: Historically, renal tubular acidosis (RTA) has been classified on a clinical basis, without any reference to the underlying disorder. Here we review the normal mechanisms of renal acidification and we identify disorders of specific transporters (genetic, disease-related or drug-induced) that lead to the main categories of distal RTA. We also describe the approach to diagnosis and the current treatment of distal RTA.
authors.affiliation: Centre for Nephrology, Department of Physiology, Royal Free and University College Medical School, London, UK. robert.unwin@ucl.ac.uk
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Unwin
authors.forename: David G
authors.initials: DG
authors.lastname: Shirley
authors.forename: Giovambattista
authors.initials: G
authors.lastname: Capasso
mesh_terms: D000141:Acidosis, Renal Tubular / Q000503:physiopathology / Q000628:therapy / Q000652:urine*; D000143:Acids / Q000378:metabolism / Q000652:urine*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007686:Kidney Tubules, Distal; D012016:Reference Values
chemical_list: D000143:Acids