title: Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes.
abstract: In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (chi(2)(1) = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.
authors.affiliation: Division of Endocrinology, the Third Affiliated Hospital of Beijing University, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.forename: Tianhua
authors.initials: T
authors.lastname: Niu
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Changzhong
authors.initials: C
authors.lastname: Chen
authors.forename: Qiongfang
authors.initials: Q
authors.lastname: Li
authors.forename: Rongli
authors.initials: R
authors.lastname: Qian
authors.forename: Guoying
authors.initials: G
authors.lastname: Wang
authors.forename: Xiping
authors.initials: X
authors.lastname: Xu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007703:Peptidyl-Dipeptidase A