Trisomy 3 in two paediatric post-transplant lymphomas.
Few cytogenetic data are available concerning the chromosomal constitution of post-transplant lymphomas. We report two paediatric cases of trisomy 3, as a primary anomaly, in post-transplant lymphoproliferative disease (PTLD) associated with B immunophenotype. Using cytogenetic analysis and fluorescence in situ hybridization on chromosome preparations, we found trisomy 3 in both patients and an extra X chromosome in one. Clinical, histological and immunophenotypical data are presented. Trisomy 3 has been observed in different types of non-Hodgkin's lymphomas but it is relatively rare in B-cell lymphomas, with the exception of marginal zone lymphoma and mantle cell lymphoma. To our knowledge, trisomy 3 is an uncommon cytogenetic finding in PTLD. Further cytogenetic studies of these lymphoproliferative disorders might contribute to evaluate the role of these chromosomal anomalies in the pathogenesis of this disease.
Gallego
Marta S
MS
Cytogenetics Laboratory, Department of Genetics, Prof. Dr. Juan B. Garrahan Pediatric Hospital, Combate de los Pozos 1881, Buenos Aires C.P 1245, Argentina. msgall@intramed.net.ar
Bernasconi
Andrea
A
Dávila
María T
MT
Rampazzi
Alejandra
A
Chantada
Guillermo
G
Gallo
Guillermo
G
Rossi
Jorge
J
Barreiro
Cristina Z
CZ
D000293:Adolescent; D002893:Chromosomes, Human, Pair 3; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007621:Karyotyping; D016030:Kidney Transplantation; D016031:Liver Transplantation; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000821:virology; D008297:Male; D011183:Postoperative Complications; D014314:Trisomy