Influence of vitamin B1 on sanazole activity under irradiation. A study in vitro.
The effect of vitamin B1 (thiamine) on sanazole (AK-2123) efficiency was investigated in vitro under irradiation, using E. coli bacteria (AB 1157) as a model. In order to get a deeper insight into the reaction mechanisms, the experiments were performed in media saturated with argon, air or N20. In the first case vitamin B1 acts as a cytostatic, but in the presence of air or N20 it shows strongly pronounced antioxidant action and leads to an essential increase of sanazole efficiency.
Heinrich
Edith
E
Ludwig Boltzmann Institute for Radiation Chemistry and Radiation Biology, The University of Vienna, Austria.
Getoff
Nikola
N
D000388:Air; D001128:Argon; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects / Q000528:radiation effects; D009609:Nitrous Oxide; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013831:Thiamine / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*
D011838:Radiation-Sensitizing Agents; D014230:Triazoles; C072690:AK 2123; D001128:Argon; D009609:Nitrous Oxide; D013831:Thiamine