Effects of superoxide dismutase/catalase mimetics on life span and oxidative stress resistance in the housefly, Musca domestica.
The purpose of this study was to determine whether superoxide dismutase/catalase mimetics lengthen the life span of the housefly, Musca domestica, as previously demonstrated for the nematode Caenorhabditis elegans. Various concentrations of Eukarion-8 or Eukarion-134 were administered via the drinking water and the effects on the life span of the flies and amounts of protein carbonyls were determined under normoxic and hyperoxic conditions. These SOD/catalase mimetics neither extended the life span of the flies nor attenuated the protein carbonyl content under normoxic conditions and shortened life span under hyperoxic conditions. Thus, the effect of these SOD/catalase mimetics on the life span of animals seem to be species-specific.
Bayne
Anne-Cécile V
AC
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA 90089-9121, USA.
Sohal
Rajindar S
RS
D000818:Animals; D002374:Catalase / Q000378:metabolism*; D005029:Ethylenediamines / Q000494:pharmacology*; D006793:Houseflies / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D008017:Life Expectancy; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology*; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D012459:Salicylates / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism*
C433928:EUK-134; D005029:Ethylenediamines; D009942:Organometallic Compounds; D012459:Salicylates; C090577:N,N'-bis(salicylideneamino)ethane-manganese(II); D002374:Catalase; D013482:Superoxide Dismutase; D010100:Oxygen