Effect of batroxobin on expression of neural cell adhesion molecule in temporal infarction rats and spatial learning and memory disorder.
The effect of Batroxobin expression of neural cell adhesion molecule (NCAM) in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemical methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats and at the same time NCAM expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of NCAM immune reactive cells of Batroxobin-treated rats was more than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats and the regulation of the expression of NCAM is probably related to the neuroprotective mechanism.
Wu
W
W
Neurotransmitter Research Laboratory, Department of Neurology, Chinese PLA General Hospital, Postgraduate Military Medical School, Beijing 100853.
Guan
X
X
Kuang
P
P
Jiang
S
S
Yang
J
J
Sui
N
N
Chen
A
A
Kuang
P
P
Zhang
X
X
D000818:Animals; D012103:Batroxobin / Q000494:pharmacology*; D015816:Cell Adhesion Molecules, Neuronal / Q000096:biosynthesis*; D002544:Cerebral Infarction / Q000378:metabolism*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013702:Temporal Lobe / Q000098:blood supply
D015816:Cell Adhesion Molecules, Neuronal; D018696:Neuroprotective Agents; D012103:Batroxobin