BSE: a consequence of cattle feeding with glycated molecules host-unknown?
Although there is much evidence supporting a prion contribution in the pathogenesis of transmissible spongiform encephalopathies, a novel point of view as to the induction of the diseases can be proposed. It is hypothesized that neurodegenerative diseases, such as scrapie in sheep and goats and bovine spongiform encephalopathy in cattle (BSE), originate from the consumption of glycated proteins contained in their feed. These components are obtained during a high-temperature glycation process.
Boratyński
J
J
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, 53-114 Poland. borat@immuno.iitd.pan.wroc.pl
Górski
A
A
D000821:Animal Feed / Q000009:adverse effects* / Q000032:analysis; D000818:Animals; D002417:Cattle; D004044:Dietary Proteins / Q000009:adverse effects* / Q000493:pharmacokinetics; D016643:Encephalopathy, Bovine Spongiform / Q000209:etiology*; D017127:Glycation End Products, Advanced / Q000009:adverse effects* / Q000493:pharmacokinetics; D006023:Glycoproteins / Q000009:adverse effects* / Q000493:pharmacokinetics; D015416:Maillard Reaction; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism; D012417:Rumen / Q000378:metabolism
D004044:Dietary Proteins; D017127:Glycation End Products, Advanced; D006023:Glycoproteins; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic