title: [Preparation of 5-fluoruracil-poly-alpha, beta(2-hydroxyethy1)-DL-asparamide and in-vivo release in rabbit].
abstract: A polymer release drug was prepared by poly-alpha, beta-(2-hydroxyethyl)-DL-asparamide(PHEA) and 5-fluorouracil. As a model drug 5-fluorouracil was conjugated into the biodegradable polymer by chemical bond. The released drug was determined to be about 37.1% (w/w) and it was characterized by IR spectrum and differential scanning calorimetry (DSC). Two forms of drugs, rod and suspension were prepared and in vivo release experiment were carried out in rabbits. The experimental result showed that the rod form of drug can in some degree reduce initial burst.
authors.affiliation: Zhejiang Medical University, Department of Pharmacy, Hangzhou 310006.
authors.forename: K
authors.initials: K
authors.lastname: Zhu
authors.forename: G
authors.initials: G
authors.lastname: Tang
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Zhou
mesh_terms: D000818:Animals; D004337:Drug Carriers; D004343:Drug Implants; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000378:metabolism; D008297:Male; D010455:Peptides / Q000008:administration & dosage* / Q000378:metabolism; D011108:Polymers; D011817:Rabbits; D011897:Random Allocation
chemical_list: C470267:5-fluorouracil-poly-alpha,beta-(2-hydroxyethyl)asparamide; D004337:Drug Carriers; D004343:Drug Implants; D010455:Peptides; D011108:Polymers; D005472:Fluorouracil