[Therapeutic efficacy of novel 17alpha-hydroxyprogesterone derivatives in experimental preterm labor].
The ability of a series of new 17 alpha-Hydroxyprogesteron derivatives (acetomepregnol, AMOL phenyl propyoate, butagest) in preventing the prostaglandin-induced preterm labor was experimentally studied in mice. It was found that all the synthetic gestagens studied, especially butagest, maintained pregnancy in all test animals on the model of enzaprost F induced abortion. The proposed progestogens can be used to prevent abortion in pregnancies in cases of risk from diseases connected with excess prostaglandin secretion.
Tapil'skaia
N I
NI
Laboratory of Pharmacology, Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, Mendeleevskaya Liniya 3, St. Petersburg, 199034 Russia.
Petrosian
M A
MA
Lesik
E A
EA
D000020:Abortifacient Agents, Nonsteroidal; D000028:Abortion, Induced; D000818:Animals; D015237:Dinoprost; D005260:Female; D051379:Mice; D007752:Obstetric Labor, Premature / Q000139:chemically induced / Q000517:prevention & control*; D011247:Pregnancy; D011374:Progesterone / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D000020:Abortifacient Agents, Nonsteroidal; C002175:progesterone 17 alpha-hydroperoxide; D011374:Progesterone; D015237:Dinoprost