title: A case of confluent and reticulated papillomatosis responsive to ketoconazole cream.
abstract: We described here a case of a 43-year-old male who developed confluent and reticulated papillomatosis (CRP). The patient was found to be slightly obese and had no family history of such eruption. Numerous small red-brown erythemas were scattered over a wide area of the back and, in many areas, the erythemas coalesced and formed a reticular pattern. The eruptions appeared 10 days prior to the initial visit to our outpatient clinic. The Parker-KOH preparation of scraped scales revealed numerous round and budding non-clustering cells and no mycelial elements. Histological examination showed subtle papillomatosis and sparse perivascular lymphohistiocytic infiltrations. Periodic acid schiff stain showed a few spores in the stratum corneum. Topical application of 2% ketoconazole cream produced complete resolution of the eruption in 7 days. The course and histological findings of our patient suggest the eruptions were developing CRP lesions. Application of topical antifungal agents appears to be a beneficial initial treatment for early CRP lesions.
authors.affiliation: Department of Dermatology, Showa University, Northern Yokohama Hospital, Japan.
authors.forename: Taizo
authors.initials: T
authors.lastname: Hamaguchi
authors.forename: Machiko
authors.initials: M
authors.lastname: Nagase
authors.forename: Ryota
authors.initials: R
authors.lastname: Higuchi
authors.forename: Iwao
authors.initials: I
authors.lastname: Takiuchi
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D008297:Male; D010212:Papilloma / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D007654:Ketoconazole