title: Maternal thyrotoxicosis causing central hypothyroidism in infants.
abstract: We describe three infants born to mothers with poorly controlled Graves' disease, who developed transient central hypothyroidism in the immediate postnatal period. Suppression of the fetal pituitary-thyroid axis may be due to placental transfer of thyroxine from the hyperthyroid mother. This may persist for months postnatally, necessitating treatment to optimise neurodevelopmental outcome.
authors.affiliation: Department of Paediatrics, National University Hospital, Singapore. paeleeys@nus.edu.sg
authors.forename: Y S
authors.initials: YS
authors.lastname: Lee
authors.forename: K Y
authors.initials: KY
authors.lastname: Loke
authors.forename: S C Y
authors.initials: SC
authors.lastname: Ng
authors.forename: R
authors.initials: R
authors.lastname: Joseph
mesh_terms: D000328:Adult; D003409:Congenital Hypothyroidism; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000517:prevention & control; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis / Q000209:etiology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications; D012846:Singapore