The Nck family of adapter proteins: regulators of actin cytoskeleton.
SH2/SH3 domain-containing adapter proteins, such as the Nck family, play a major role in regulating tyrosine kinase signalling. They serve to recruit proline-rich effector molecules to tyrosine-phosphorylated kinases or their substrates. Initially, it was not clear why cells from nematodes to vertebrates contain redundant and closely related SH2/SH3 adapters, such as Grb2, Crk and Nck. Recent evidence suggests that their biological roles are clearly different, whereas, for example, Grb2 connects activated receptor tyrosine kinases to Sos and Ras, leading to cell proliferation. The proteins of Nck family are implicated in organisation of actin cytoskeleton, cell movement or axon guidance in flies. In this review, the author attempts to summarise signalling pathways in which Nck plays a critical role.
Buday
László
L
Department of Medical Chemistry, Semmelweis University Medical School, 9 Puskin Str., 1088, Budapest, Hungary. buday@puskin.sote.hu
Wunderlich
Livius
L
Tamás
Peter
P
D008841:Actin Cytoskeleton / Q000378:metabolism*; D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001369:Axons / Q000502:physiology; D029721:Drosophila Proteins; D016023:Integrins / Q000378:metabolism; D008213:Lymphocyte Activation; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000502:physiology; D015513:Oncogene Proteins / Q000737:chemistry / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology; D018909:src Homology Domains
D048868:Adaptor Proteins, Signal Transducing; D029721:Drosophila Proteins; D016023:Integrins; C078332:Nck protein; D009419:Nerve Tissue Proteins; D015513:Oncogene Proteins; C099753:dock protein, Drosophila; D017346:Protein Serine-Threonine Kinases; D016283:Proto-Oncogene Proteins p21(ras)