Neuroregulation of cough: implications for drug therapy.
There have been remarkable advances recently in our understanding of the neuroregulation of cough in three areas: the properties of the sensory nerves, in particular their receptors and membrane channels; the plasticity of the pathways; and the central nervous mechanisms of cough. All these studies are relevant to our understanding of the pharmacology and therapy of cough.
Widdicombe
John
J
Guy's, King's and St Thomas' School of Biomedical Sciences, Human Physiology and Aerospace Medicine, Shepherd's House, Guy's Campus, London Bridge, SE1 9RT, UK. JohnWiddicombeJ@aol.com
D000818:Animals; D003371:Cough / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D009424:Nervous System Physiological Phenomena; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000502:physiology