Initial study in rats evaluating the effects of 1,4-dichlorobutene-2 (DCB) on the respiratory tract.
Rats were exposed by inhalation to either 0.5 ppm 1,4-dichlorobutene-2 (DCB) for two years or to 5.0 ppm for seven months, 2.5 ppm for five months, and no further exposure for 12 months prior to sacrifice. Malignant and non-malignant tumors of the nasal tissues were seen in both test groups with the incidence and proportion of malignant tumors being much higher in the 5.0/2.5 ppm rats. Under the conditions of this study, DCB is carcinogenic in rats of both sexes.
Mullin
L S
LS
E.I. du Pont de Nemours and Company, Haskell Laboratory for Health and Environmental Sciences, P.O. Box 50, Newark, DE 19714-0050, USA.
Chiu
T
T
Kennedy
G L
GL
D000280:Administration, Inhalation; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D002277:Carcinoma / Q000139:chemically induced / Q000556:secondary; D004305:Dose-Response Relationship, Drug; D005260:Female; D006843:Hydrocarbons, Chlorinated / Q000008:administration & dosage / Q000633:toxicity*; D019570:Inhalation Exposure; D008136:Longevity / Q000187:drug effects; D008297:Male; D009669:Nose Neoplasms / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012137:Respiratory System / Q000187:drug effects* / Q000473:pathology
D002273:Carcinogens; D006843:Hydrocarbons, Chlorinated; C010709:1,4-dichloro-2-butene