title: Application of disposable plastic microfluidic device arrays with customized chemistries to multiplexed biochemical assays.
abstract: Plastic microfluidic array platforms and synergistic multiplexed assay chemistries are under development for a variety of applications, including assays of gene expression, proteomics, genotyping, DNA sequencing and fragment analysis, sample preparation and high-throughput pharmaceutical discovery. The low production costs of plastic substrates makes possible economical single-use device arrays, eliminating cleaning and sample-to-sample carryover contamination. Hundreds of microchannels and reservoirs are readily included on a single microtitre-plate-size substrate, enabling the manufacture of highly parallel fluidic array systems to increase throughput and speed.
authors.affiliation: ACLARA BioSciences, Inc., 1288 Pear Avenue, Mountain View, CA 94043, U.S.A. aricco@aclara.com
authors.forename: A J
authors.initials: AJ
authors.lastname: Ricco
authors.forename: T D
authors.initials: TD
authors.lastname: Boone
authors.forename: Z H
authors.initials: ZH
authors.lastname: Fan
authors.forename: I
authors.initials: I
authors.lastname: Gibbons
authors.forename: T
authors.initials: T
authors.lastname: Matray
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.forename: H
authors.initials: H
authors.lastname: Tan
authors.forename: T
authors.initials: T
authors.lastname: Tian
authors.forename: S J
authors.initials: SJ
authors.lastname: Williams
mesh_terms: D004353:Drug Evaluation, Preclinical / Q000295:instrumentation; D020869:Gene Expression Profiling / Q000295:instrumentation; D006801:Humans; D008832:Microchemistry / Q000295:instrumentation*; D008904:Miniaturization; D010969:Plastics; D017422:Sequence Analysis, DNA / Q000295:instrumentation
chemical_list: D010969:Plastics