[Role of HLA phenotype in the formation of chronic hepatitis C virus infection].
Clinical, biochemical and immunological parameters depending on HLA-phenotypic features were examined in 107 patients aged 18-78 years with chronic hepatitis C virus (HCV) infection. Clinical and biochemical manifestations (asthenic, pain and cytolytic syndromes, hepatomegalia, hyperbilirubinemia, hypoprothrombin- and proteinemia), observed in hepatitis C, were more pronounced in patients having HLA-A30, B35, B41, Cw2, A1-B35, A9-B8. The carriers of B8 and B35 antigens were found to have inadequate immune response in HCV infection, manifested by progressive chronic process in the liver and the development of cirrhosis in patients with such specificity.
Bondarenko
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AL
State Medical Academy, Kirov, Russia.
Baramzina
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SV
D000293:Adolescent; D000328:Adult; D000368:Aged; D006680:HLA Antigens / Q000502:physiology*; D015234:HLA-A Antigens / Q000502:physiology; D015788:HLA-A1 Antigen / Q000502:physiology; D015235:HLA-B Antigens / Q000502:physiology; D015797:HLA-B35 Antigen / Q000502:physiology; D015795:HLA-B8 Antigen / Q000502:physiology; D015236:HLA-C Antigens / Q000502:physiology; D019698:Hepatitis C, Chronic / Q000209:etiology / Q000276:immunology*; D006579:Heterozygote; D006801:Humans; D008875:Middle Aged; D010641:Phenotype; D012426:Russia
D006680:HLA Antigens; D015234:HLA-A Antigens; C069526:HLA-A*30 antigen; D015788:HLA-A1 Antigen; C037709:HLA-A9 antigen; D015235:HLA-B Antigens; D015797:HLA-B35 Antigen; C056322:HLA-B41 antigen; D015795:HLA-B8 Antigen; D015236:HLA-C Antigens; C048767:HLA-C*02 antigen