title: Symptomatic and asymptomatic benign prostatic hyperplasia: molecular differentiation by using microarrays.
abstract: Benign prostatic hyperplasia (BPH) is a disease of unknown etiology that significantly affects the quality of life in aging men. Histologic BPH may present itself either as symptomatic or asymptomatic in nature. To elucidate the molecular differences underlying BPH, gene expression profiles from the prostate transition zone tissue have been analyzed by using microarrays. A set of 511 differentially expressed genes distinguished symptomatic and asymptomatic BPH. This genetic signature separates BPH from normal tissue but does not seem to change with age. These data could provide novel approaches for alleviating symptoms and hyperplasia in BPH.
authors.affiliation: Gene Logic Inc., 708 Quince Orchard Road, Gaithersburg, MD 20878, USA.
authors.forename: Kulkarni
authors.initials: K
authors.lastname: Prakash
authors.forename: Gregorio
authors.initials: G
authors.lastname: Pirozzi
authors.forename: Michael
authors.initials: M
authors.lastname: Elashoff
authors.forename: William
authors.initials: W
authors.lastname: Munger
authors.forename: Iwao
authors.initials: I
authors.lastname: Waga
authors.forename: Rajiv
authors.initials: R
authors.lastname: Dhir
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kakehi
authors.forename: Robert H
authors.initials: RH
authors.lastname: Getzenberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D000906:Antibodies; D003937:Diagnosis, Differential; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D020411:Oligonucleotide Array Sequence Analysis; D010446:Peptide Fragments / Q000276:immunology; D011467:Prostate / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology
chemical_list: D000906:Antibodies; D010446:Peptide Fragments