Mg++SO4 treatment improves the hemodynamics following the acute myocardial ischemia and reperfusion.
BACKGROUND
The effect of Mg++SO4 on myocardial hemodynamics was investigated in this study.


METHODS
Twelve dogs were entered in this research. Six dogs received Mg++SO4 and the remaining dogs were considered as controls. The amount of Mg++SO4 that was administered to the animals was 0.15 mmol/kg/hr each. The left anterior descending artery was occluded for a period of 1 hour and the drug was administered during reperfusion.


RESULTS
Two hours after reperfusion, cardiac output was 1275+/-50 ml/min in the control group and 1475+/-25 ml/min in the Mg++SO4 group (p<0.05), pulmonary capillary wedge pressure was 18+/-3 mmHg in the control group and 12+/-2 mmHg in the Mg++SO4 group.


CONCLUSIONS
In this study it was shown that Mg++SO4 usage after 1 hour arterial occlusion and 2 hours reperfusion protects the heart from the adverse effects of ischemia/reperfusion and had a better central hemodynamics.
Karapinar
K
K
SSK Ankara Hospital, Ankara, Turkey.
Ulus
A T
AT
Kaplan
S
S
Tütün
U
U
Saritas
A
A
Aksöyek
A
A
Apaydn
N
N
Saritas
Z
Z
Katircioglu
S F
SF
D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology
D008278:Magnesium Sulfate