[Antihypoxic activity of the novel intraorganoid pharmacological preparation mitochondrin].
The antihypoxant and membranoprotector properties of the new intraorganoid pharmacological preparation mitochondrin (M-1) were studied in two series of experiments. In the first series, the drug activity was studied on a model of hypoxia with hypercapny; in the second series, the drug was tested on a model of hemic hypoxia caused by neurotoxic damage (acute nitrobenzene intoxication). It was established that M-1 (obtained from the brain tissue of newborn rabbits) possesses antihypoxant activity, which is manifested in both hypoxia--hypercapnia and hemic hypoxia. The drug effect was more pronounced 3 h after administration than on the next day. The antihypoxant action of M-1 is related to the cytomembrane neuroprotector activity.
Makarenko
A N
AN
Institute of Pharmacology and Toxicilogy, Academy of Medical Sciences of Ukraine, ul. Ezhena Pot'e 14, Kiev, 02057 Ukraine.
Klebanskiĭ
E O
EO
Shirobokova
L P
LP
D000818:Animals; D001921:Brain / Q000648:ultrastructure; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D000860:Hypoxia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000737:chemistry; D009578:Nitrobenzenes; D009997:Osmotic Pressure; D011817:Rabbits; D051381:Rats; D014020:Tissue Extracts / Q000302:isolation & purification / Q000627:therapeutic use*
D009578:Nitrobenzenes; D014020:Tissue Extracts; C036077:nitrobenzene