title: Activities of therapeutic agents and myristamidopropyl dimethylamine against Acanthamoeba isolates.
abstract: The activities of therapeutic agents and myristamidopropyl dimethylamine (MAPD) against Acanthamoeba strains recalcitrant to medical therapy were studied. MAPD minimum cysticidal concentrations were 6.25 to 25 microg/ml; 10 to 30 microg/ml gave at least a 3-log cyst kill after 6 h, and 50 and 100 microg/ml gave at least a 3-log cyst kill within 2 and 1 h, respectively.
authors.affiliation: Department of Microbiology and Immunology, University of Leicester, Leicester, United Kingdom. sk46@leicester.ac.uk
authors.forename: Simon
authors.initials: S
authors.lastname: Kilvington
authors.forename: Reanne
authors.initials: R
authors.lastname: Hughes
authors.forename: James
authors.initials: J
authors.lastname: Byas
authors.forename: John
authors.initials: J
authors.lastname: Dart
mesh_terms: D000048:Acanthamoeba / Q000187:drug effects*; D015823:Acanthamoeba Keratitis / Q000382:microbiology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004351:Drug Resistance; D006801:Humans; D011437:Propylamines / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000981:Antiprotozoal Agents; D011437:Propylamines; C401661:myristamidopropyl dimethylamine