title: Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders.
abstract: We studied polymorphisms of mitochondrial DNA 5178cytosine/adenine (mt5178C/A) and angiotensin I-converting enzyme (ACE) genes (DCP1) in 127 cerebrovascular disorder (CVD) patients and 294 age-matched normal controls to clarify the genetic background of Japanese patients with CVD. Mt5178C was predominant in CVD patients compared with controls (P<0.01). The frequency of DCP1 insertion (I) and deletion (D) alleles showed no significant difference between the CVD patients and controls or between each CVD subgroup. Although the number of CVD patients in the present study was too small to make a final conclusion, mt5178C might be one of the genetic factors to be considered in Japanese patients with CVD.
authors.affiliation: Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, 8-35-1 Sakuragaoka, Kagoshima, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ohkubo
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Ikeda
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kodama
authors.forename: Kimiyoshi
authors.initials: K
authors.lastname: Arimura
authors.forename: Suminori
authors.initials: S
authors.lastname: Akiba
authors.forename: Minoru
authors.initials: M
authors.lastname: Saito
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Ookatsu
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Atsuchi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Yamano
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Osame
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic; D012016:Reference Values; D012307:Risk Factors
chemical_list: D004272:DNA, Mitochondrial; D007703:Peptidyl-Dipeptidase A