title: Cardiac troponin T levels are associated with poor short- and long-term prognosis in patients with acute cardiogenic pulmonary edema.
abstract: BACKGROUND
  The clinical determinants of increased cardiac troponin T (cTnT) in patients with acute cardiogenic pulmonary edema are not well defined, and the ability of this marker to predict long-term mortality has not yet been documented.
  
  
  METHODS
  Eighty-four patients with acute cardiogenic pulmonary edema without acute myocardial infarction were prospectively enrolled. cTnT was measured in samples obtained 6 and 12 hours after admission.
  
  
  RESULTS
  cTnT levels of 0.1 ng/mL or greater were found in 46 patients (55%). Thirty-two patients (38%) died during follow-up. The area under the receiver operating characteristic curve for cTnT was 0.70 and 0.69 at 6 and 12 hours (P =.47), and the cTnT cutoff value of 0.1 ng/mL was 66% and 69% sensitive and 63% and 71% specific, respectively, in predicting subsequent mortality. Patients were assigned to group 1 if they had cTnT lower than 0.1 ng/mL and to group 2 if they had cTnT levels of 0.1 ng/mL or greater. A history of coronary artery disease was present in 72% of group 2 versus 50% of group 1 patients (P =.04). Patients in group 2 were also older than those in group 1 (mean age, 68 years vs 61 years; P =.021). The 3-year survival in group 1 was 76% compared with 29% in group 2 (log-rank test, P <.001). In a Cox proportional hazards model, elevated cTnT emerged as the only prognostic marker of long-term mortality (risk ratio [RR] = 2.31; 95% CI, 1.011-5.280; P =.047).
  
  
  CONCLUSIONS
  A cTnT level of 0.1 ng/mL or greater was associated with poor long-term survival and emerged as a powerful independent predictor of mortality in patients with acute cardiogenic pulmonary edema.
authors.affiliation: Coronary Intensive Care Unit, Instituto de Cardiología Juana F. Cabral, Corrientes, Argentina. pernaucic@hotmail.com
authors.forename: Eduardo Roque
authors.initials: ER
authors.lastname: Perna
authors.forename: Stella Maris
authors.initials: SM
authors.lastname: Macín
authors.forename: Jorge Isaac
authors.initials: JI
authors.lastname: Parras
authors.forename: Rolando
authors.initials: R
authors.lastname: Pantich
authors.forename: Eduardo Francisco
authors.initials: EF
authors.lastname: Farías
authors.forename: Jorge Reynaldo
authors.initials: JR
authors.lastname: Badaracco
authors.forename: Eloise
authors.initials: E
authors.lastname: Jantus
authors.forename: Fernanda
authors.initials: F
authors.lastname: Medina
authors.forename: Mónica
authors.initials: M
authors.lastname: Brizuela
mesh_terms: D000208:Acute Disease; D000368:Aged; D000704:Analysis of Variance; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D006333:Heart Failure / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011654:Pulmonary Edema / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D012680:Sensitivity and Specificity; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T