title: Inverted papilloma of the nasal cavity presenting with massive amounts of squamous metaplastic cells in sputum. A case report.
abstract: BACKGROUND
  Squamous metaplasic cells are rarely seen in sputum of female nonsmokers.
  
  
  METHODS
  A 47-year-old female nonsmoker presented with massive amounts of squamous metaplasic cells in sputum and an elevated level of squamous cell carcinoma (SCC) antigen in serum present for months, while no causative lesion was detected either by lung computed tomography or bronchoscopy. The patient was eventually diagnosed as having inverted papilloma in the right nasal cavity. Resection of the tumor brought about disappearance of squamous metaplastic cells in sputum and return of serum SCC antigen to the normal range.
  
  
  CONCLUSIONS
  This case clearly demonstrates that squamous metaplastic cells in sputum can originate in lesions in the nasal cavity, although they are rare. It should be kept in mind that the nasal cavity is a potential site producing squamous metaplastic cells in sputum.
authors.affiliation: First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Furuta
authors.forename: Katsuji
authors.initials: K
authors.lastname: Marukawa
authors.forename: Jun
authors.initials: J
authors.lastname: Moriya
authors.forename: Mikio
authors.initials: M
authors.lastname: Shimizu
authors.forename: Mikio
authors.initials: M
authors.lastname: Arakawa
authors.forename: Tomoo
authors.initials: T
authors.lastname: Itoh
authors.forename: Michio
authors.initials: M
authors.lastname: Shimizu
authors.forename: Shinichi
authors.initials: S
authors.lastname: Fukumoto
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ogura
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Dosaka-Akita
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood; D003581:Cytodiagnosis / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008679:Metaplasia; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology; D009669:Nose Neoplasms / Q000175:diagnosis / Q000473:pathology*; D018308:Papilloma, Inverted / Q000175:diagnosis / Q000473:pathology*; D015843:Serpins; D013183:Sputum / Q000166:cytology*
chemical_list: D000951:Antigens, Neoplasm; D015843:Serpins; C051072:squamous cell carcinoma-related antigen