title: Transcription factor fusions in acute leukemia: variations on a theme.
abstract: The leukemia-associated fusion proteins share several structural or functional similarities, suggesting that they may impart a leukemic phenotype through common modes of transcriptional dysregulation. The fusion proteins generated by these translocations usually contain a DNA-binding domain, domains responsible for homo- or hetero-dimerization, and domains that interact with proteins involved in chromatin remodeling (e.g., co-repressor molecules or co-activator molecules). It is these shared features that constitute the 'variations on the theme' that underling the aberrant growth and differentiation that is the hallmark of acute leukemia cells.
authors.affiliation: Laboratory of Molecular Aspects of Hematopoiesis, Sloan-Kettering Institute Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Scandura
authors.forename: Piernicola
authors.initials: P
authors.lastname: Boccuni
authors.forename: Jorg
authors.initials: J
authors.lastname: Cammenga
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Nimer
mesh_terms: D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D028861:Nuclear Pore Complex Proteins / Q000737:chemistry; D015514:Oncogene Proteins, Fusion / Q000737:chemistry* / Q000378:metabolism*; D018168:Receptors, Retinoic Acid / Q000737:chemistry; D000072482:Retinoic Acid Receptor alpha; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D028861:Nuclear Pore Complex Proteins; D015514:Oncogene Proteins, Fusion; C000607071:RARA protein, human; C000607072:Rara protein, mouse; D018168:Receptors, Retinoic Acid; D000072482:Retinoic Acid Receptor alpha; D014157:Transcription Factors