title: N-allyl-4-(N-2'-hydroxyethyl)amino-1,8-naphthalimide as a fluorophore for optical chemosensing of nitrofurantoin.
abstract: N-Allyl-4-(N-2'-hydroxyethyl)amino-1,8-naphthalimide (AHEAN), a naphthalimide derivative, was synthesized as a new fluorophore for optical chemical sensor preparation. To prevent leakage of the fluorophore, AHEAN was photo-copolymerized with 2-hydroxypropyl methacrylate on a glass surface treated with a silanizing agent. An optical chemical sensor based on AHEAN can be utilized for nitrofurantoin assay based on fluorescence quenching. The sensor shows sufficient repeatability, selectivity and a fast response of less than 30 s. Nitrofurantoin can be determined in the range between 1.00 x 10(-6) and 1.00 x 10(-3) mol l(-1) with a detection limit of 4.8 x 10(-7) mol l(-1). Most commonly co-existing drug substances and ions do not interfere with the nitrofurantoin assay. The sensor was applied to the analysis of pharmaceutical and urine samples.
authors.affiliation: State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
authors.forename: Cheng-Gang
authors.initials: CG
authors.lastname: Niu
authors.forename: Xing
authors.initials: X
authors.lastname: Yang
authors.forename: Wei-Qi
authors.initials: WQ
authors.lastname: Lin
authors.forename: Guo-Li
authors.initials: GL
authors.lastname: Shen
authors.forename: Ru-Qin
authors.initials: RQ
authors.lastname: Yu
mesh_terms: D000498:Allyl Compounds; D000890:Anti-Infective Agents / Q000032:analysis* / Q000652:urine; D005456:Fluorescent Dyes; D009281:Naphthalenes; D053644:Naphthalimides; D009582:Nitrofurantoin / Q000032:analysis* / Q000652:urine; D004364:Pharmaceutical Preparations / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D000498:Allyl Compounds; D000890:Anti-Infective Agents; D005456:Fluorescent Dyes; C455580:N-allyl-4-(N-2'-hydroxyethyl)amino-1,8-naphthalimide; D009281:Naphthalenes; D053644:Naphthalimides; D004364:Pharmaceutical Preparations; D009582:Nitrofurantoin