title: Diastolic filling abnormalities by color kinesis in newborns exposed to intrauterine cocaine.
abstract: Because cocaine crosses the placenta, we prospectively evaluated global and segmental systolic and diastolic cardiac function by color kinesis in clinically asymptomatic newborns who were exposed to cocaine in utero (group 1, n = 82). Their data were compared with normal controls (group 3, n = 87) and newborns exposed to drugs other than cocaine (group 2, n = 108). During left ventricular filling, newborns exposed to cocaine, compared with groups 2 and 3, had significantly (P <.05) higher global fractional area change (%) (76 +/- 10.3 vs 72 +/- 9.4 and 72 +/- 9.1, respectively), regional fractional area changes (%) for the anterior, septal, inferior, and lateral wall, and in the index of asynchrony (at 50% filling 13.2 +/- 5.8 vs 11.3 +/- 4.1 and 11.6 +/- 4.2, respectively). There were no significant differences in systolic function among the 3 groups. Prenatal cocaine exposure in asymptomatic infants leads to higher global and segmental fractional area changes and asynchrony during diastole. The significance and course of these alterations require further investigation.
authors.affiliation: Department of Pediatrics, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio, USA. Ken.mehta@fairviewhospital.org
authors.forename: Sudhir Ken
authors.initials: SK
authors.lastname: Mehta
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Super
authors.forename: Ann
authors.initials: A
authors.lastname: Salvator
authors.forename: Lynn
authors.initials: L
authors.lastname: Singer
authors.forename: David
authors.initials: D
authors.lastname: Connuck
authors.forename: Linda Goetz
authors.initials: LG
authors.lastname: Fradley
authors.forename: Rose A
authors.initials: RA
authors.lastname: Harcar-Sevcik
authors.forename: James D
authors.initials: JD
authors.lastname: Thomas
authors.forename: Jing Ping
authors.initials: JP
authors.lastname: Sun
mesh_terms: D003042:Cocaine / Q000633:toxicity*; D003971:Diastole / Q000502:physiology; D018618:Echocardiography, Doppler, Color; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011446:Prospective Studies; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D003042:Cocaine