title: Antimicrobial susceptibility of Neisseria gonorrhoeae isolated in Bangladesh (1997 to 1999): rapid shift to fluoroquinolone resistance.
abstract: Periodic monitoring of antimicrobial susceptibility of Neisseria gonorrhoeae is essential for early detection of emergence of drug resistance. A total of 343 gonococcal strains isolated from high-risk and general populations in Bangladesh from 1997 to 1999 were studied. The MICs of penicillin, tetracycline, ciprofloxacin, ceftriaxone, and spectinomycin for the isolates were determined by the agar dilution method. Of the isolates from 1997, 9% were resistant (MIC >or= 1.0 microg/ml) to ciprofloxacin, while 41 and 49% of the isolates from 1998 and 1999, respectively, were resistant to ciprofloxacin. Of the N. gonorrhoeae isolates from 1998 and 1999, 1.2 and 3.6%, respectively, both were penicillinase producing and displayed plasmid-mediated tetracycline resistance.
authors.affiliation: International Center for Diarrheal Disease Research, Bangladesh. motiur@icddrb.org
authors.forename: Motiur
authors.initials: M
authors.lastname: Rahman
authors.forename: Zafar
authors.initials: Z
authors.lastname: Sultan
authors.forename: Shirajum
authors.initials: S
authors.lastname: Monira
authors.forename: Ashraful
authors.initials: A
authors.lastname: Alam
authors.forename: Khairun
authors.initials: K
authors.lastname: Nessa
authors.forename: Sonia
authors.initials: S
authors.lastname: Islam
authors.forename: Shamsun
authors.initials: S
authors.lastname: Nahar
authors.lastname: Shama-A-Waris
authors.forename: Shahnewaz
authors.initials: S
authors.lastname: Alam Khan
authors.forename: Jozef
authors.initials: J
authors.lastname: Bogaerts
authors.forename: Nazrul
authors.initials: N
authors.lastname: Islam
authors.forename: John
authors.initials: J
authors.lastname: Albert
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D001459:Bangladesh; D002939:Ciprofloxacin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D006069:Gonorrhea / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000302:isolation & purification; D010403:Penicillin Resistance / Q000235:genetics; D013753:Tetracycline Resistance / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002939:Ciprofloxacin