title: Markers of oxidative injury in the cerebrospinal fluid of a premature infant with meningitis and periventricular leukomalacia.
abstract: Free radicals have been hypothesized to play a key role in the evolution of periventricular leukomalacia, although direct evidence of oxidative injury in the human infant is lacking. This case report is the first to demonstrate a marked elevation in the levels of lipid and protein oxidative products in the cerebrospinal fluid during the evolution of periventricular leukomalacia in a premature infant with meningitis.
authors.affiliation: Murdoch Children's Research Institute and Howard Florey Institute, Royal Women's Hospital, Melbourne, Australia.
authors.forename: Terrie
authors.initials: T
authors.lastname: Inder
authors.forename: Tessa
authors.initials: T
authors.lastname: Mocatta
authors.forename: Brian
authors.initials: B
authors.lastname: Darlow
authors.forename: Carole
authors.initials: C
authors.lastname: Spencer
authors.forename: Revathy
authors.initials: R
authors.lastname: Senthilmohan
authors.forename: Christine C
authors.initials: CC
authors.lastname: Winterbourn
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Volpe
mesh_terms: D015415:Biomarkers; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007969:Leukomalacia, Periventricular / Q000134:cerebrospinal fluid* / Q000382:microbiology / Q000473:pathology; D015227:Lipid Peroxidation; D008279:Magnetic Resonance Imaging; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000150:complications; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers