Markers of oxidative injury in the cerebrospinal fluid of a premature infant with meningitis and periventricular leukomalacia.
Free radicals have been hypothesized to play a key role in the evolution of periventricular leukomalacia, although direct evidence of oxidative injury in the human infant is lacking. This case report is the first to demonstrate a marked elevation in the levels of lipid and protein oxidative products in the cerebrospinal fluid during the evolution of periventricular leukomalacia in a premature infant with meningitis.
Inder
Terrie
T
Murdoch Children's Research Institute and Howard Florey Institute, Royal Women's Hospital, Melbourne, Australia.
Mocatta
Tessa
T
Darlow
Brian
B
Spencer
Carole
C
Senthilmohan
Revathy
R
Winterbourn
Christine C
CC
Volpe
Joseph J
JJ
D015415:Biomarkers; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007969:Leukomalacia, Periventricular / Q000134:cerebrospinal fluid* / Q000382:microbiology / Q000473:pathology; D015227:Lipid Peroxidation; D008279:Magnetic Resonance Imaging; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000150:complications; D018384:Oxidative Stress
D015415:Biomarkers