title: Three major glucose-6-phosphate dehydrogenase-deficient polymorphic variants identified in Mazandaran state of Iran.
abstract: We report the first investigation of glucose- 6-phosphate dehydrogenase (G6PD) deficiency among the Mazandaranians in the north of Iran. We analysed the G6PD gene in 74 unrelated G6PD-deficient men with a history of favism. Molecular analysis revealed three major different polymorphic variants: G6PD Mediterranean 66.2% (49 out of 74), G6PD Chatham 27% (20 out of 74), G6PD Cosenza 6.75% (5 out of 74). These findings indicated a higher prevalence of G6PD Chatham in this Iranian population than anywhere else in the world. In addition, the distribution of these G6PD variants is more similar to that found in an Italian population than in other Middle Eastern countries.
authors.affiliation: Department of Biochemistry, School of Medical Sciences, Tarbiat Modarres University, PO Box 14115-331, Tehran, I.R. Iran. mesbahna@modares.ac.ir
authors.forename: Seyed A
authors.initials: SA
authors.lastname: Mesbah-Namin
authors.forename: Mohammad H
authors.initials: MH
authors.lastname: Sanati
authors.forename: Alireza
authors.initials: A
authors.lastname: Mowjoodi
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Mason
authors.forename: Tom J
authors.initials: TJ
authors.lastname: Vulliamy
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Noori-Daloii
mesh_terms: D002648:Child; D002675:Child, Preschool; D005236:Favism / Q000209:etiology; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications / Q000208:ethnology* / Q000235:genetics*; D006801:Humans; D007492:Iran; D008297:Male; D009154:Mutation; D011110:Polymorphism, Genetic
chemical_list: D005954:Glucosephosphate Dehydrogenase