2-triazenoindoles: synthesis and biological activity.
A series of 2-triazenoindole derivatives was prepared in moderate to good yields by coupling 2-diazoindoles with secondary amines. Only 3-ethoxycarbonyl-2-(3.3-tetramethylenetriazenyl)-indole, tested against a panel of 60 human tumor cell lines, showed moderate activity on breast, ovarian and CNS cancer with GI50 in the range 23-36 microM.
Barraja
Paola
P
Dipartimento Farmacochimico Tossicologico e Biologico, Università degli Studi, Palermo, Italy.
Diana
Patrizia
P
Lauria
Antonino
A
Montalbano
Alessandra
A
Almerico
Anna Maria
AM
Dattolo
Gaetano
G
Cirrincione
Girolamo
G
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014226:Triazenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007211:Indoles; D014226:Triazenes