title: Safe use of livers from donors with positive hepatitis B core antibody.
abstract: Thirty-five patients received liver transplants using liver donors who had positive test results for the hepatitis B core antibody (HBcAb). In the same time frame, 195 patients received HBcAb-negative liver donors. Mean follow up for patients receiving HBcAb-positive donors was 25 months. All patients receiving HBcAb-positive donors were monitored for recurrence of hepatitis B (HBV) with HBV DNA assays. There was no de novo HBV in recipients of HBcAb-negative grafts. In the group of patients receiving HBcAb-positive donors, 4 of 35 patients died within 3 months after transplant with no evidence of HBV recurrence at time of death. Four patients were transplanted for HBV-related disease and were postoperatively placed on lamivudine and hepatitis B immune globulin (HBIG). HBV recurrence was seen in one of these patients. Of the remaining 27 patients, three of three mismatched patients (HBcAb-positive donor to HBcAb-negative recipient) developed de novo HBV (100%). Of 24 matched patients (HBcAb-positive donor to HBcAb-positive recipient), only two (7%) developed recurrent HBV allograft reinfection. All de novo and recurrent HBV infections were successfully managed with HBIG and lamivudine therapy. Survival for this subgroup of patients receiving HBcAb-positive donors for non-HBV-related liver disease was 100%. We conclude that the judicious use of HBcAb-positive donors is reasonably safe and associated with low morbidity and mortality, with the appropriate follow-up protocols. Additionally, lamivudine use can be reserved for those cases with de novo or recurrent HBV in the liver allograft, or, selectively, as prophylaxis in those recipients patients who are naïve to HBV and receive an HBcAb-positive donor.
authors.affiliation: Center for Liver Diseases and Liver Transplant Program, Albert Einstein Medical Center, Philadelphia, PA 19141, USA. manzarbc@einstein.edu
authors.forename: Cosme
authors.initials: C
authors.lastname: Manzarbeitia
authors.forename: David J
authors.initials: DJ
authors.lastname: Reich
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Ortiz
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Rothstein
authors.forename: Victor R
authors.initials: VR
authors.lastname: Araya
authors.forename: Santiago J
authors.initials: SJ
authors.lastname: Munoz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006509:Hepatitis B / Q000601:surgery / Q000635:transmission*; D006512:Hepatitis B Core Antigens; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D019259:Lamivudine / Q000627:therapeutic use; D016031:Liver Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014019:Tissue Donors
chemical_list: D006512:Hepatitis B Core Antigens; D007166:Immunosuppressive Agents; D019259:Lamivudine