[Are drugs necessary in the treatment of obesity?].
BACKGROUND
The main principles of obesity treatment are dietetic nutrition, physical activity and psychotherapy. Drug therapy is adjuvant, time limited and can be applied only with the mentioned therapeutic measures. An ideal antiadipose agent induces a potent decrease of body mass on the account of fat depot, it can be administered for a prolonged time without developing resistance, it should not be accompanied by significant side effects, and it has no negative effects on the obesity-related diseases. ANTI-OBESITY AGENTS: Nowadays, there are mainly two groups of drugs in use, having different mechanisms of action: appetite suppressors and fat resorption inhibitors. From the first group of drugs the most suitable is dexfenfluramine, which is applied in obese nervous and tense subjects and in cases of compulsive food intake whereas fat resorption inhibitors (tetrahydrolipstatin, orlistat) are especially recommended to obese patients with accompanying hyperlipoproteinemia. Insulin-dependent form of diabetes is an indication for administration of drugs from this group.


CONCLUSIONS
Of course, before applying drugs it is necessary to thoroughly consider indications and especially contraindications of their action. In respect to the treatment duration, three-month treatments are mainly recommended. Prolonged courses are acceptable only if well-controlled studies are in question.
Ivković-Lazar
Tatjana
T
Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Institut za interne bolesti, Klinicki centar, Novi Sad.
Stokić
Edita
E
Lepsanović
Lazar
L
D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D001067:Appetite Depressants / Q000627:therapeutic use; D006801:Humans; D008049:Lipase / Q000037:antagonists & inhibitors; D009765:Obesity / Q000188:drug therapy*
D019440:Anti-Obesity Agents; D001067:Appetite Depressants; D008049:Lipase