[Daphnia magna for studies of cholinergic preparations].
Published data and original experimental results are summarized to justify biochemically the use of Daphnia magna Straus as an additional or alternative test object for the study of cholinotropic substances. The data of radioligand analysis provide direct evidence that the organism of Daphnia contains M-cholinoreceptors identical (with respect to pharmacodynamic parameters) to those in the human and animal organism.
Podosinovikova
N P
NP
Institute of Toxicology, Ministry of Public Health of the Russian Federation, ul. Bekhtereva 1, St. Petersburg, 193019 Russia.
Kosmachev
A B
AB
Tonkopiĭ
V D
VD
Zagrebin
A O
AO
Evdokimova
E A
EA
Malov
A M
AM
Petrov
V V
VV
Dolgo-Saburov
V B
VB
D000818:Animals; D002415:Cats; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D003621:Daphnia / Q000378:metabolism*; D004285:Dogs; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D011869:Radioligand Assay; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism; D013045:Species Specificity
D018680:Cholinergic Antagonists; D011976:Receptors, Muscarinic