Novel therapies for the treatment of prostate cancer: current clinical trials and development strategies.
The number of treatment options for patients with prostate cancer is expanding, as mechanism-based therapies enter clinical testing. Such strategies are based on manipulating tumoral genetics, cell signaling, apoptosis, angiogenesis, the immune system, and others. To properly develop these agents, traditional trial designs and outcome measures require reconsideration. This review describes these novel drugs and their targets using a clinical states model. Investigators use a clinical states model as a framework for matching specific agents with the needs of the treatment population and the biology of the tumor at any given point in the natural history of the disease.
Morris
Michael J
MJ
Department of Genitourinary Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 444, New York, NY 10021, USA. morrism@mskcc.org
Scher
Howard I
HI
D000256:Adenoviridae / Q000235:genetics; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D017209:Apoptosis; D002986:Clinical Trials as Topic / Q000379:methods*; D016158:Genes, p53; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology / Q000628:therapy*; D013792:Thalidomide / Q000627:therapeutic use
D020533:Angiogenesis Inhibitors; D013792:Thalidomide; D017430:Prostate-Specific Antigen