Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics.
Inspired by the structure of tannic acid, first- to third-generation dendrimers containing two, four, and eight galloyl moieties were synthesized. Stability, antioxidant activity and collagen cross-linking activity of the natural product and its dendrimer analogues were compared. The experimental results indicate that polygalloyl dendrimers might be used as new lead compounds to improve the long-term healing characteristics of burn wounds.
Halkes
S Bart A
SB
Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
Vrasidas
Ioannis
I
Rooijer
Gilbert R
GR
van den Berg
Albert J J
AJ
Liskamp
Rob M J
RM
Pieters
Roland J
RJ
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D005707:Gallic Acid / Q000737:chemistry*; D047348:Hydrolyzable Tannins / Q000737:chemistry* / Q000494:pharmacology; D018716:Molecular Mimicry
D000975:Antioxidants; D047348:Hydrolyzable Tannins; D005707:Gallic Acid