title: Database of bronchoalveolar lavage fluid proteins.
abstract: Bronchoalveolar lavage during fiberoptic bronchoscopy is extensively used for investigating cellular and biochemical alterations of the epithelial lining fluid in various lung disorders. Two-dimensional electrophoresis (2-DE) offers the possibility to simultaneously display and analyze proteins contained in bronchoalveolar lavage fluid (BALF). We present the current status of 2-DE of BALF samples with an updated listing of the proteins already identified and of their level and/or posttranslational alterations in lung disorders. Alternatives to 2-DE of BALF samples and future prospects of proteomics to unravel lung functions and pathologies are discussed.
authors.affiliation: Department of Biological Chemistry, University of Mons-Hainaut, Avenue du Champs de Mars 6, B-7000 Mons, Belgium. isabelle.georis@umh.ac.be
authors.forename: Isabelle
authors.initials: I
authors.lastname: Noël-Georis
authors.forename: Alfred
authors.initials: A
authors.lastname: Bernard
authors.forename: Paul
authors.initials: P
authors.lastname: Falmagne
authors.forename: Ruddy
authors.initials: R
authors.lastname: Wattiez
mesh_terms: D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D030562:Databases, Protein; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins