title: Regulation of neurogenesis by neurotrophins in developing spinal sensory ganglia.
abstract: Neurons and glia in spinal sensory ganglia derive from multipotent neural crest-derived stem cells. In contrast to neural progenitor cells in the central nervous system, neural crest progenitors coexist with differentiated sensory neurons all throughout the neurogenic period. Thus, developing sensory ganglia are advantageous for determining the possible influence of cell-cell interactions in the regulation of precursor proliferation and neurogenesis. Neurotrophins are important regulators of neuronal survival in the developing vertebrate nervous system and, in addition, they appear to influence precursor behavior in vitro. Studies in mice carrying mutations in neurotrophin genes provide a good system in which to analyze essential actions of these factors on the different developing neural populations.
authors.affiliation: Departamento de Biología Celular, Universidad de Valencia, Burjassot, Spain. isabel.farinas@uv.es
authors.forename: Isabel
authors.initials: I
authors.lastname: Fariñas
authors.forename: Marifé
authors.initials: M
authors.lastname: Cano-Jaimez
authors.forename: Elena
authors.initials: E
authors.lastname: Bellmunt
authors.forename: Mario
authors.initials: M
authors.lastname: Soriano
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D005727:Ganglia, Spinal / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D051379:Mice; D009414:Nerve Growth Factors / Q000172:deficiency* / Q000235:genetics*; D009432:Neural Crest / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D009457:Neuroglia / Q000166:cytology* / Q000378:metabolism; D009475:Neurons, Afferent / Q000166:cytology* / Q000378:metabolism; D017475:Receptors, Nerve Growth Factor / Q000235:genetics / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*
chemical_list: D009414:Nerve Growth Factors; D017475:Receptors, Nerve Growth Factor