Characterization of the Aspergillus nidulans 14-3-3 homologue, ArtA.
The 14-3-3 family of proteins function as small adaptors that facilitate a diverse array of cellular processes by mediating specific protein interactions. One such process is the DNA damage checkpoint, where these proteins prevent inappropriate activation of cyclin-dependent kinases. The filamentous fungus Aspergillus nidulans possesses a highly conserved 14-3-3 homologue (artA) that may function in an analogous manner to prevent septum formation. However, instead of blocking septation, over-expression of artA causes a severe delay in the polarization of conidiospores. This observation suggests that these proteins play an important role in hyphal morphogenesis.
Kraus
Peter R
PR
Department of Microbiology, University of Connecticut Health Center, Farmington 06030-3205, USA.
Hofmann
Amy F
AF
Harris
Steven D
SD
D048948:14-3-3 Proteins; D000595:Amino Acid Sequence; D001233:Aspergillus nidulans / Q000378:metabolism*; D003001:Cloning, Molecular; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D010957:Plasmids; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014446:Tyrosine 3-Monooxygenase / Q000737:chemistry
D048948:14-3-3 Proteins; D005656:Fungal Proteins; D014446:Tyrosine 3-Monooxygenase