title: LDL-cholesterol and HDL-cholesterol concentrations decrease during the day.
abstract: BACKGROUND
  Homogenous assays for LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) are highly accurate, with little interference from triglyceride. Using these methods, we measured postprandial LDL-C and HDL-C. Earlier studies suggested a postprandial decrease in LDL-C.
  
  
  METHODS
  To elucidate whether LDL-C and HDL-C decrease significantly during the day, we determined daily profiles of LDL-C and HDL-C using homogeneous assays in subjects with normal coronary arteries (N; n=10), and subjects with coronary artery disease (CAD; n=23).
  
  
  RESULTS
  In both groups, LDL-C and HDL-C were significantly lower from after breakfast until midnight than they were before breakfast. The next morning, they returned to baseline levels. The mean reduction in LDL-C was 0.09-0.13 mmol/L in N and 0.05-0.20 mmol/L in CAD, while that in HDL-C was 0.02-0.06 mmol/L in N and 0.00-0.05 mmol/L in CAD.
  
  
  CONCLUSIONS
  LDL-C and HDL-C decrease significantly over the course of the day.
authors.affiliation: Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan. miida@med.niigata-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Miida
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Toru
authors.initials: T
authors.lastname: Mezaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Hanyu
authors.forename: Seitaro
authors.initials: S
authors.lastname: Maruyama
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Horikawa
authors.forename: Sachiko
authors.initials: S
authors.lastname: Izawa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yamada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsui
authors.forename: Masahiko
authors.initials: M
authors.lastname: Okada
mesh_terms: D000328:Adult; D000418:Albumins / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood* / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000097:blood* / Q000378:metabolism*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D000418:Albumins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides