Effects of synthetic siderophores on proliferation of Plasmodium falciparum in infected human erythrocytes.
Because iron is essential for Plasmodium falciparum, we investigated the in vitro potential of various synthetic siderophores to kill P. falciparum in infected human erythrocytes. The substances with the most promising profile, i.e., low 50% lethal doses for plasmodia and minimum toxicity towards mammalian cells, were siderophores with an acylated monocatecholate or a triscatecholate as substituent.
Rotheneder
Andrea
A
Department of Internal Medicine, University Hospital of Innsbruck, University of Innsbruck, A-6020 Innsbruck, Austria.
Fritsche
Gernot
G
Heinisch
Lothar
L
Möllmann
Ute
U
Heggemann
Susanne
S
Larcher
Clara
C
Weiss
Günter
G
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D066298:In Vitro Techniques; D007502:Iron Chelating Agents / Q000494:pharmacology; D020014:K562 Cells; D007928:Lethal Dose 50; D010963:Plasmodium falciparum / Q000187:drug effects*; D017262:Siderophores / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity
D000962:Antimalarials; D007502:Iron Chelating Agents; D017262:Siderophores