title: Focal epileptiform activity in the brain: detection with spike-related functional MR imaging--preliminary results.
abstract: The purpose of this study was to develop a spike-related functional magnetic resonance (MR) imaging method to detect epileptic brain activity. Correlations between simultaneous spike-related functional MR imaging and electroencephalographic (EEG) recordings were performed in 10 patients with focal epilepsy. Postprocessing techniques were implemented to eliminate contamination of the EEG recording from ballistocardiography and the echo-planar MR imaging sequence. A diagnostic EEG recording was achieved during functional MR imaging. Spike location correlated with the site of blood oxygen level-dependent signal increase. Spike-related functional MR imaging is a promising technique for detecting focal epileptic brain activity.
authors.affiliation: Institute of Clinical Radiology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81366 Munich, Germany. jaeger@ikra.med.uni-muenchen.de
authors.forename: Lorenz
authors.initials: L
authors.lastname: Jäger
authors.forename: Konrad J
authors.initials: KJ
authors.lastname: Werhahn
authors.forename: Alexander
authors.initials: A
authors.lastname: Hoffmann
authors.forename: Sophia
authors.initials: S
authors.lastname: Berthold
authors.forename: Verena
authors.initials: V
authors.lastname: Scholz
authors.forename: Jürgen
authors.initials: J
authors.lastname: Weber
authors.forename: Soheyl
authors.initials: S
authors.lastname: Noachtar
authors.forename: Maximilian
authors.initials: M
authors.lastname: Reiser
mesh_terms: D000328:Adult; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged