title: 8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
abstract: A series of bicyclic heteroaryl ring systems was considered as a replacement for the 3-cyclopentyloxy-4-methoxyphenyl moiety in rolipram resulting in the discovery of 8-methoxyquinoline-5-carboxamides as potent inhibitors of phosphodiesterase type 4 (PDE4).
authors.affiliation: Celltech R&D, Granta Park, Great Abington, Cambridge CB1 6GS, UK.
authors.forename: George M
authors.initials: GM
authors.lastname: Buckley
authors.forename: Nicola
authors.initials: N
authors.lastname: Cooper
authors.forename: Hazel J
authors.initials: HJ
authors.lastname: Dyke
authors.forename: Fiona P
authors.initials: FP
authors.lastname: Galleway
authors.forename: Lewis
authors.initials: L
authors.lastname: Gowers
authors.forename: Alan F
authors.initials: AF
authors.lastname: Haughan
authors.forename: Hannah J
authors.initials: HJ
authors.lastname: Kendall
authors.forename: Christopher
authors.initials: C
authors.lastname: Lowe
authors.forename: Robert
authors.initials: R
authors.lastname: Maxey
authors.forename: John G
authors.initials: JG
authors.lastname: Montana
authors.forename: Robert
authors.initials: R
authors.lastname: Naylor
authors.forename: Janet
authors.initials: J
authors.lastname: Oxford
authors.forename: Joanna C
authors.initials: JC
authors.lastname: Peake
authors.forename: C Louise
authors.initials: CL
authors.lastname: Picken
authors.forename: Karen A
authors.initials: KA
authors.lastname: Runcie
authors.forename: Verity
authors.initials: V
authors.lastname: Sabin
authors.forename: Andrew
authors.initials: A
authors.lastname: Sharpe
authors.forename: Julie B H
authors.initials: JB
authors.lastname: Warneck
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000577:Amides / Q000494:pharmacology / Q000627:therapeutic use*; D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D006801:Humans; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000577:Amides; D018927:Anti-Asthmatic Agents; D010726:Phosphodiesterase Inhibitors; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4