Auditory ERP in extremely premature 5-year-old children.
The aim of this research was to test the hypothesis of a functional impairment in the automatic detection of deviant tones in 141 children born after 25 to 28 weeks of gestational age, as compared to 45 age-matched full-term control children. All of them were assessed at age 5 years 9 months and instructed to listen passively to two different pure tones (1000 vs 1200 Hz; 20 vs 80%) counterbalanced between ears. Rarity was thus defined by specific ear by tone combinations. The temporal N100 showed a clear contralateral functional organization of the central auditory pathway, especially for the left ear, but without group difference. By contrast, in full-term controls but not in premature children, the central N200 was specifically increased over frontal leads to rare stimuli as compared to frequent. Premature children demonstrated a lack of brain response when more complex processing integrating different informations was required.
Léveillé
Jasmin
J
Department of Psychiatry, Sainte-Justine Hospital, University of Montréal, Québec, Canada. philippe.robaey@umontreal.ca
Robaey
Philippe
P
Ge
Yong-Liang
YL
Lefebvre
Francine
F
D000161:Acoustic Stimulation; D001034:Apgar Score; D001306:Auditory Pathways / Q000503:physiopathology; D001308:Auditory Perceptual Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D002648:Child; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male