title: [PAX-6 gene promoter polymorphism and other factors involved in brain atrophy in alcohol dependent patients].
abstract: PAX-6 gene promoter polymorphism, alcohol dependence history and CT were determined in the group of 68 alcoholics. We found negative correlation between numbers of PAX-6 gene promoter B (AC)m (AG)n repeats and atrophy of the brain and the cerebellum. Occurrence of these lesions was correlated with a decrease of alcohol tolerance, withdrawal symptoms--especially delirium tremens.
authors.affiliation: Katedry i Kliniki Psychiatrii PAM w Szczecinie.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Samochowiec
authors.forename: Jolanta
authors.initials: J
authors.lastname: Kucharska-Mazur
authors.forename: Jan
authors.initials: J
authors.lastname: Horodnicki
authors.forename: Klaus Peter
authors.initials: KP
authors.lastname: Lesch
authors.forename: Hans
authors.initials: H
authors.lastname: Rommelspacher
authors.forename: Lutz Gerhard
authors.initials: LG
authors.lastname: Schmidt
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics* / Q000473:pathology*; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D005136:Eye Proteins; D005260:Female; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins
chemical_list: D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; C000605730:PAX6 protein, human; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins