title: Pyridazines. Part 28: 5-alkylidene-6-phenyl-3(2H)-pyridazinones, a new family of platelet aggregation inhibitors.
abstract: The synthesis and anti-platelet activity of several 5-alkylidene-6-phenyl-3(2H)-pyridazinones are described. The most active compounds are those that contain oxygenated functions (COOR, COMe) on the alkylidene fragment (6a, 6b and 6c).
authors.affiliation: Departamento de Química Orgánica, Laboratorio de Química Farmacéutica, Universidad de Santiago de Compostela, 15782-Santiago de Compostela, Spain.
authors.forename: Eddy
authors.initials: E
authors.lastname: Sotelo
authors.forename: Nuria
authors.initials: N
authors.lastname: Fraiz
authors.forename: Matilde
authors.initials: M
authors.lastname: Yáñez
authors.forename: Reyes
authors.initials: R
authors.lastname: Laguna
authors.forename: Ernesto
authors.initials: E
authors.lastname: Cano
authors.forename: José
authors.initials: J
authors.lastname: Brea
authors.forename: Enrique
authors.initials: E
authors.lastname: Raviña
mesh_terms: D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D010975:Platelet Aggregation Inhibitors; D011724:Pyridazines