title: Test-retest precision of functional magnetic resonance imaging processed with independent component analysis.
abstract: This study was designed to compare the test-retest precision of functional magnetic resonance imaging (fMRI) data processed with independent component analysis (ICA) and the same data analyzed with a conventional model-dependent method (Student's- t mapping). Volunteers underwent two or three iterations of visual and auditory stimuli, while data were collected for fMRI scans. The scan data were separately processed with ICA and with Student's- t mapping (STM). As a measure of test-retest precision, concurrence ratios were calculated for each subject and each task as the number of voxels that were activated by two iterations of a task divided by the average number of voxels activated in each repetition. In 28 test-retest comparisons, the average concurrence ratio was 0.69+/-0.10 for ICA and 0.65+/-0.13 for the conventional method, a statistically insignificant difference. In fMR image data of block stimulus paradigms, ICA had similar test-retest precision to a conventional model-dependent method.
authors.affiliation: Department of Radiology, The University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison 53792, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Nybakken
authors.forename: M A
authors.initials: MA
authors.lastname: Quigley
authors.forename: C H
authors.initials: CH
authors.lastname: Moritz
authors.forename: D
authors.initials: D
authors.lastname: Cordes
authors.forename: V M
authors.initials: VM
authors.lastname: Haughton
authors.forename: M E
authors.initials: ME
authors.lastname: Meyerand
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D025341:Principal Component Analysis; D012044:Regression Analysis; D015203:Reproducibility of Results