Growth hormone and the skeleton in pediatric renal allograft recipients.
Recombinant human growth hormone has been utilized to augment linear growth in pediatric renal allograft recipients. The skeletal changes that accompany growth hormone therapy have not been described in children. Thus, 23 stable prepubertal pediatric kidney recipients, aged 10 +/- 3 years, with a mean transplant time of 3.4 +/- 2.5 years and histological findings of normal bone formation and adynamic bone on bone biopsies were prospectively randomized into two groups. These comprised a treated group that received 12 months of growth hormone and a control group that did not receive any treatment. Anthropometric measurements and blood for serum calcium, phosphorus, parathyroid hormone (PTH), osteocalcin, and insulin-like growth factor-I (IGF-I) were obtained every 3 months. Measurements of bone mass by dual-energy X-ray absorptiometry were performed at the beginning and end of the study period. All patients underwent an initial and final bone biopsy procedure after double tetracycline labeling. Annual growth velocity increased and standard deviation scores for height improved in the treated group. Serum IGF-I levels increased in the treated group and the increase was evident in patients with normal bone formation who received growth hormone but not in patients with adynamic bone. Serum calcium, phosphorus, osteocalcin, and PTH levels did not differ between the treated and control groups. Bone mass did not change in the treated group, but declined after 12 months in the control group. Bone formation rates did not increase with growth hormone treatment. Thus, growth hormone therapy improves linear growth and maintains bone mass, but does not favorably affect bone formation rates in stable pediatric renal allograft recipients.
Sanchez
Cheryl P
CP
Department of Pediatrics, University of Wisconsin Medical School, 3590 MSC/Pediatrics, 1300 University Avenue, Madison, WI 53706, USA. cpsanchez@facstaff.wisc.edu
Kuizon
Beatriz D
BD
Goodman
William G
WG
Gales
Barbara
B
Ettenger
Robert B
RB
Boechat
M Inez
MI
Wang
Yang
Y
Elashoff
Robert
R
Salusky
Isidro B
IB
D000365:Age Determination by Skeleton; D000886:Anthropometry; D001769:Blood / Q000378:metabolism; D015519:Bone Density; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D002648:Child; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D016030:Kidney Transplantation; D008297:Male; D010012:Osteogenesis; D011182:Postoperative Care; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000627:therapeutic use; D014184:Transplantation, Homologous
D011994:Recombinant Proteins; D019382:Human Growth Hormone