Inositol polyphosphate 5-phosphatases: lipid phosphatases with flair.
Recent studies have identified the inositol polyphosphate 5-phosphatases as a large family of signal modifying enzymes comprising 10 mammalian and 4 yeast family members. A number of investigations including gene-targeted deletion of 5-phosphatases in mice have demonstrated that these enzymes regulate many important cellular events including hematopoietic cell proliferation and activation, insulin signaling, endocytosis, and actin polymerization.
Mitchell
Christina A
CA
Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia. Christina.Mitchell@med.monash.edu.au
Gurung
Rajendra
R
Kong
Anne M
AM
Dyson
Jennifer M
JM
Tan
April
A
Ooms
Lisa M
LM
D000818:Animals; D020013:Calcium Signaling; D018390:Gene Targeting; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D007295:Inositol Phosphates / Q000378:metabolism; D000072181:Inositol Polyphosphate 5-Phosphatases; D007328:Insulin / Q000378:metabolism; D008954:Models, Biological; D009800:Oculocerebrorenal Syndrome / Q000201:enzymology / Q000235:genetics; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics; D015398:Signal Transduction; D013572:Synaptic Vesicles / Q000378:metabolism
D007295:Inositol Phosphates; D007328:Insulin; C081655:inositol-1,3,4,5-tetrakisphosphate; D015544:Inositol 1,4,5-Trisphosphate; D010744:Phosphoric Monoester Hydrolases; D000072181:Inositol Polyphosphate 5-Phosphatases