title: Lack of association between gene polymorphism of transporters associated with antigen processing and allergic rhinitis in a Japanese population.
abstract: Gene products of TAP1 and TAP2 (transporters associated with antigen processing) are involved in antigen presentation. It has been reported that polymorphisms in the TAP1 gene are associated with atopy in Tunisians. We designed a case-control study to investigate the potential association of polymorphisms of the TAP1 gene with allergic rhinitis in a Japanese population. We used the amplification refractory mutation system polymerase chain reaction to characterize TAP1 gene polymorphisms in 60 unrelated Japanese patients with allergic rhinitis and 62 healthy control subjects. There was no significant difference in the distribution of TAP1 alleles between the patient group and the control group. These findings suggest that the TAP1 gene is not primarily involved in susceptibility to allergic rhinitis in the Japanese population.
authors.affiliation: Department of Otorhinolaryngology, Mie University School of Medicine, Tsu, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Saori
authors.initials: S
authors.lastname: Abe
authors.forename: Sawako
authors.initials: S
authors.lastname: Masuda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yuta
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Majima
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sakakura
mesh_terms: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000483:Alleles; D017931:DNA Primers / Q000235:genetics; D004587:Electrophoresis, Agar Gel; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007564:Japan; D008285:Major Histocompatibility Complex; D008297:Male; D017720:Molecular Epidemiology; D009154:Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012221:Rhinitis, Allergic, Perennial / Q000453:epidemiology / Q000235:genetics*; D012737:Sex Factors
chemical_list: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; D017931:DNA Primers; C073119:TAP1 protein, human