[The transcriptional regulation of the TCA1 elements and their effects on morphogenesis of Candida albicans].
We have cloned two copies of retrotransposon-like elements Tca1-1 and Tca1-2 (Transposon Candida albicans) from Candida albicans strain SC5314. Comparing the restriction maps of the two genomic fragments, similar patterns were observed. The two composite elements were transcribed into an approximately unit length 6 kb RNA. The expression of this transcript was greatly increased when cells were grown at 25 degrees C versus 37 degrees C. Deletion of the partial or complete intervening region of the Tca1-1 element causes the morphogenetic variation of the cells. The morphogenetic variation is in cooperation with the expression of the URA3 gene.
Wang
Q
Q
State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai 200031.
Fu
Z
Z
Zhou
S
S
Chen
J Y
JY
D002176:Candida albicans / Q000166:cytology / Q000235:genetics* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics*; D005656:Fungal Proteins / Q000096:biosynthesis; D009024:Morphogenesis / Q000235:genetics*; D016254:Mutagenesis, Insertional; D010940:Plant Proteins / Q000235:genetics*; D018626:Retroelements / Q000235:genetics*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D010940:Plant Proteins; D018626:Retroelements; C084056:TCA-1 protein, Nicotiana tabacum