title: Extracorporeal respiratory support and minimally invasive ventilation in severe ARDS.
abstract: BACKGROUND
  To evaluate the results of treatment of severe acute respiratory distress syndrome (ARDS) with extracorporeal life support (ECLS), minimal sedation and low pressure supported ventilation in adults.
  
  
  METHODS
  
  
  
  METHODS
  observational study in a tertiary referral center, Intensive Care Unit, Astrid Lindgren Children's Hospital at Karolinska Hospital, Stockholm, Sweden.
  
  
  METHODS
  thirty-eight patients aged 17-61 years (mean 38) with severe ARDS. The Murray score of pulmonary injury averaged 3.5 (3.0-4.0) and the mean PaO2/FiO2 ratio was 47 (31-65).
  
  
  METHODS
  the patients were treated with veno-venous or veno-arterial ECLS after failure of conventional respiratory therapy. A standard ECLS circuit with no heparinized surfaces was used. The patients were minimally sedated and received pressure-supported ventilation. High inspiratory pressures were avoided.
  
  
  RESULTS
  25 of the 38 patients survived (total survival rate 66%) after 2-57 days on ECLS (mean 17). Major surgical procedures were performed in several patients during bypass.
  
  
  CONCLUSIONS
  A high survival rate can be obtained in adult patients with severe ARDS using ECLS, minimal sedation and pressure-supported ventilation with low inspiratory pressures. Surgical complications are amenable to surgical treatment during ECLS and bleeding problems can be controlled.
authors.affiliation: Department of Pediatric Surgery, Astrid Lindgren Children's Hospital, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Frenckner
authors.forename: P
authors.initials: P
authors.lastname: Palmér
authors.forename: V
authors.initials: V
authors.lastname: Lindén
mesh_terms: D000293:Adolescent; D000328:Adult; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000628:therapy*