title: Sources of the scalp-recorded amplitude-modulation following response.
abstract: The scalp-recorded amplitude-modulation following response (AMFR) is gaining recognition as an objective audiometric tool, but little is known about the neural sources that underlie this potential. We hypothesized, based on our human studies and single-unit recordings in animals, that the scalp-recorded AMFR reflects the interaction of multiple sources. We tested this hypothesis using an animal model, the unanesthetized rabbit. We compared AMFRs recorded from the surface of the brain at different locations and before and after the administration of agents likely to enhance or suppress neural generators. We also recorded AMFRs locally at several stations along the auditory neuraxis. We conclude that the surface-recorded AMFR is indeed a composite response from multiple brain generators. Although the response at any modulation frequency can reflect the activity of more than one generator, the AMFRs to low and high modulation frequencies appear to reflect a strong contribution from cortical and subcortical sources, respectively.
authors.affiliation: Department of Neuroscience, University of Connecticut Health Center, Farmington 06030-3405, USA.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Kuwada
authors.forename: Julia S
authors.initials: JS
authors.lastname: Anderson
authors.forename: Ranjan
authors.initials: R
authors.lastname: Batra
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Fitzpatrick
authors.forename: Natacha
authors.initials: N
authors.lastname: Teissier
authors.forename: William R
authors.initials: WR
authors.lastname: D'Angelo
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D011817:Rabbits