Genetics of latent autoimmune diabetes in adults.
Slowly progressive insulin-dependent diabetes mellitus (IDDM), like classical IDDM, is also associated with genetic markers. HLA-DR3 but not DR4 is associated with latent autoimmune diabetes in adults (LADA). In GAD65 antibody-positive Finnish LADA patients, DQB1*0302 is positively associated with the disease. Alleles of the MHC class I chain-related A (MICA) gene located centromeric to the HLA-B gene is associated with LADA. Allele 5.1 of MICA was associated with both LADA and adult-onset Italian IDDM patients when compared to controls. This finding was also observed in Indian and Latvian patients with LADA. These findings suggest that certain genetic markers distinguish LADA better.
Sanjeevi
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CB
Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden. sanjeevi.carani@molmed.ki.se
Gambelunghe
G
G
Falorni
A
A
Shtauvere-Brameus
A
A
Kanungo
A
A
D000328:Adult; D017668:Age of Onset; D000483:Alleles; D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A