title: Integrin connections map: to infinity and beyond.
abstract: Integrins are transmembrane proteins that serve as primary sensors of the extracellular matrix (ECM) environment. In response to interactions with the ECM, integrins initiate signaling pathways that regulate cell migration, growth, and survival. Advances in imaging have contributed to the understanding of the dynamic nature of these cell-ECM interactions and the complexes that form at these sites and have provided insights into their regulation and signal organizing functions.
authors.affiliation: Department of Microbiology, University of Virginia Health System, Box 800734, Charlottesville, VA 22908-0734, USA.
authors.forename: Karen H
authors.initials: KH
authors.lastname: Martin
authors.forename: Jill K
authors.initials: JK
authors.lastname: Slack
authors.forename: Scott A
authors.initials: SA
authors.lastname: Boerner
authors.forename: Clifford C
authors.initials: CC
authors.lastname: Martin
authors.forename: J Thomas
authors.initials: JT
authors.lastname: Parsons
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D002448:Cell Adhesion; D002470:Cell Survival; D005109:Extracellular Matrix / Q000378:metabolism; D022001:Focal Adhesions / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D016023:Integrins; D018631:ras Proteins; D020741:rho GTP-Binding Proteins