Relapse of thrombotic thrombocytopenic purpura associated with decreased VWF cleaving activity.
Thrombotic thrombocytopenic purpura (TTP) is an uncommon syndrome characterized by reversible, systemic aggregation of platelets in the microcirculation and disseminated microvascular thrombosis. Surgery may precipitate TTP and has been associated with relapse in some patients. However, relapse of this life-threatening disorder is unpredictable. We report a patient with an antecedent history of TTP who experienced a relapse after elective cardiac surgery. In this case, decreased von Willebrand factor (vWF)-cleaving metalloproteinase activity and an inhibitor of this endogenous enzyme were demonstrated preoperatively. These findings suggest that decreased vWF-cleaving metalloproteinase activity and/or the presence of its inhibitor may predict an increased risk for surgical-associated relapse of TTP.
Anstadt
Mark P
MP
manstadt@mail.mcg.edu
Carwile
John M
JM
Guill
Carrie K
CK
Conklin
Lori D
LD
Soltero
Ernesto R
ER
Lucci
Anthony
A
Kroll
Michael H
MH
D000328:Adult; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008666:Metalloendopeptidases / Q000097:blood; D010974:Platelet Aggregation; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood* / Q000209:etiology* / Q000628:therapy; D012008:Recurrence; D012307:Risk Factors; D014841:von Willebrand Factor / Q000378:metabolism*
D014841:von Willebrand Factor; D008666:Metalloendopeptidases