Effect of hypertonic saline solution on the left ventricular functions of isolated hearts from burned rats.
OBJECTIVE
To study the effect of hypertonic saline solution on the left ventricular functions of isolated hearts from burned rats.


METHODS
Thirty-six Wistar rats were used and divided into 4 groups: (1) normal hearts perfused with isotonic Krebs-Henseleit solution; (2) normal hearts perfused with Krebs-Henseleit solution which contained 215 mmol/L Na+; (3) hearts of rats suffered from 25% TBSA third degree burn and perfused with isotonic Krebs-Henseleit solution; (4) hearts of the burned rats perfused with Krebs-Henseleit solution which contained 215 mmol/L Na+. The systolic and diastolic functions of the left ventricle were observed.


RESULTS
During perfusion, there were very short periods of decrease in heart systolic and diastolic functions at first, but they recovered very soon and even became stronger than normal both in the normal and burned rats. The systolic and diastolic functions of the hearts increased very significantly when the perfusion solution was changed to isotonic solution from the hypertonic solutions. The effect of the hypertonic saline solution on the ventricular systolic and diastolic improvements was stronger in the hearts of the burned rats than that in the normal hearts.


CONCLUSIONS
Hypertonic saline solution can directly affect myocardium and significantly improve the ventricular systolic and diastolic functions, especially in the hearts of the burned rats.
Zhou
Jihong
J
Institute of Surgery Research, Daping Hospital, the Third Military Medical University, Chongqing 400042, China. jhzhou@mail.tmmu.com.cn
Liu
Dawei
D
Wang
Zhengguo
Z
Zhu
Peifang
P
D000818:Animals; D002056:Burns / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000187:drug effects; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D016277:Ventricular Function, Left / Q000187:drug effects*
D012462:Saline Solution, Hypertonic