title: Nodular type and older age as the most significant associations of thick melanoma in Victoria, Australia.
abstract: OBJECTIVE
  To explore the clinical associations of thick melanoma and to compare the clinicopathological variables of nodular and superficial spreading types.
  
  
  METHODS
  Cross-sectional study of all invasive primary melanomas recorded by the Victorian Cancer Registry for 1998 and those reviewed by the Victorian Melanoma Service between October 1, 1994, and April 31, 1999.
  
  
  METHODS
  Population-based cancer registry and public hospital-based multidisciplinary melanoma clinic.
  
  
  METHODS
  This study included 1422 patients recorded by the Victorian Cancer Registry and 674 patients who had attended the Victorian Melanoma Service; unclassifiable tumor types were excluded, leaving 1144 and 645 patients, respectively, eligible for analysis.
  
  
  METHODS
  Melanomas were categorized by thickness into thin (< or =1 mm), intermediate (>1-3 mm), and thick (>3 mm) and compared according to patient age, sex, and tumor type and site. Superficial spreading and nodular types were also compared in this manner. Use of the Victorian Melanoma Service database enabled a more comprehensive analysis of historical and phenotypic characteristics.
  
  
  RESULTS
  Thick melanoma was predominantly nodular, occurring in older men, mostly on the head and neck and associated with fewer nevi. Nodular melanoma was thicker and found mostly on the lower limbs or head and neck; it had a greater association with a history of solar keratoses than did superficial spreading melanoma.
  
  
  CONCLUSIONS
  Nodular type and older age are the most significant associations of thick melanoma.
authors.affiliation: Victoria Melanoma Service, Prahran, Australia.
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Chamberlain
authors.forename: Lin
authors.initials: L
authors.lastname: Fritschi
authors.forename: Graham G
authors.initials: GG
authors.lastname: Giles
authors.forename: John P
authors.initials: JP
authors.lastname: Dowling
authors.forename: John W
authors.initials: JW
authors.lastname: Kelly
mesh_terms: D000367:Age Factors; D003430:Cross-Sectional Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000473:pathology*; D012042:Registries; D012737:Sex Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000473:pathology*; D014739:Victoria / Q000453:epidemiology