Description of a novel HLA-DRB1 allele, DRB1*1207.
A new DRB1 allele has been identified during routine HLA-DRB1 generic typing with sequence specific oligonucleotides. The new allele was confirmed by PCR-restriction fragment length polymorphism analysis and subsequently sequenced. This showed the novel allele, named HLA-DRB1*1207, was similar in sequence to DRB1*12011, except for codon 69 of exon 2.
Dunckley
Heather
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Tissue Typing Department, Australian Red Cross Blood Service, Sydney, NSW, Australia. hdunckley@arcbs.redcross.org.au
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Dodd
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Hogbin
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Strickland
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Chapman
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Greville
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D000483:Alleles; D001483:Base Sequence; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains