title: [A case-control study on family history of Alzheimer's disease].
abstract: OBJECTIVE
  To explore the relationship between Alzheimer's disease and its family history of the patients.
  
  
  METHODS
  Stratified analyses and logistic regression analysis were used to examine the association between Alzheimer's disease and its family history exposure in 127 cases and 254 matched controls from a population-based case-control study.
  
  
  RESULTS
  The risk of Alzheimer's disease was significantly higher in those who had at least one first-degree relative with dementia or major psychosis as compared to those who had no dementia or major relatives with psychosis (OR = 6.25; 8.33). Adjusted for age and level of education, family history of dementia was still associated with Alzheimer's disease positively (OR = 2.07).
  
  
  CONCLUSIONS
  This study provides evidence that familial aggregation of Alzheimer's disease might exist among people living Beijing.
authors.affiliation: Department of Epidemiology, Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China.
authors.forename: Jiahong
authors.initials: J
authors.lastname: Yao
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Zhenxin
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003704:Dementia / Q000235:genetics; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000235:genetics