Oral treatment with Lactococcus lactis expressing Staphylococcus hyicus lipase enhances lipid digestion in pigs with induced pancreatic insufficiency.
The Staphylococcus hyicus lip gene was cloned in Lactococcus lactis. Pancreatic insufficiency was induced by ligation of the pancreatic duct in pigs. In pigs who had undergone pancreatic ligation, the coefficient of fat absorption was higher after consumption of lipase-expressing L. lactis (91.9% +/- 3.7%) than that after consumption of the inactive control strain (78.4% +/- 2.4%).
Drouault
Sophie
S
Unité d'Ecologie et de Physiologie du Systeme Digestif, Institut National de la Recherche Agronomique, 78350 Jouy en Josas, France.
Juste
Catherine
C
Marteau
Philippe
P
Renault
Pierre
P
Corthier
Gérard
G
D000818:Animals; D004064:Digestive System / Q000382:microbiology; D004195:Disease Models, Animal; D013294:Lactococcus lactis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008026:Ligation; D008049:Lipase / Q000235:genetics / Q000378:metabolism*; D050356:Lipid Metabolism; D010182:Pancreatic Diseases / Q000378:metabolism / Q000628:therapy*; D010183:Pancreatic Ducts; D019936:Probiotics; D013210:Staphylococcus / Q000201:enzymology; D013552:Swine; D014162:Transfection
D008049:Lipase