Drugs, leads, and drug-likeness: an analysis of some recently launched drugs.
An analysis of the origins of recently launched drugs reveals that most were derived by modification of known drug structures or from lead structures obtained from the scientific literature. High-throughput screening did not have a significant impact on the derivation of these drugs. The drug structures are very closely related to their leads.
Proudfoot
John R
JR
Boehringer Ingelheim Pharmaceuticals Inc., Department of Medicinal Chemistry, 900 Ridgebury Road, PO Box 368, Ridgefield, CT 06877, USA. jrproudfo@rdg.boehringer-ingelheim.com
D015195:Drug Design; D004355:Drug Stability; D015394:Molecular Structure