[Hyperlipidemia in the elderly].
Many studies show hypercholesterolemia is an even stronger risk factor for coronary heart disease(CHD) in the elderly, and most studies evaluated ischemic strokes separately show a positive association with cholesterol levels. Large prevention studies show HMG-CoA reductase inhibitors significantly decreased major coronary events in the elderly similar to that observed in the younger people, and were also effective in preventing ischemic stroke. For primary prevention, therapeutic life-style change is the first line of therapy for the elderly. However, LDL-lowering drugs can be considered when they are at established CHD, higher risk because of multiple risk factors, or advanced subclinical atherosclerosis. The association of triglycerides level or HDL-cholesterol level and atherosclerotic diseases has been well defined in the elderly.
Kawano
Mikihiko
M
Department of Clinical Laboratory Medicine, Jichi Medical School.
D000368:Aged; D003327:Coronary Disease / Q000517:prevention & control*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents