Treatment of Scedosporium apiospermum brain abscesses with posaconazole.
A 41-year-old man with acute lymphoblastic leukemia developed multiple Scedosporium apiospermum brain abscesses. The infection progressed despite neurosurgical drainage and treatment with itraconazole, amphotericin B, and ketoconazole, but the brain abscesses completely resolved after treatment with posaconazole alone.
Mellinghoff
Ingo K
IK
Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA, 90095, USA.
Winston
Drew J
DJ
Mukwaya
Geoffrey
G
Schiller
Gary J
GJ
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001922:Brain Abscess / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008271:Mycetoma / Q000188:drug therapy*; D021681:Scedosporium / Q000187:drug effects; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole