Investigating the use of primary adult subventricular zone neural precursor cells for neuronal replacement therapies.
With the relatively recent discovery that neurogenesis persists throughout life in restricted regions of the adult mammalian brain, including those of human beings, there has been great interest in the use of adult-derived neural stem cells for neuronal replacement. There are many great hurdles that must be overcome in order for such replacement strategies to succeed. In this review, we outline some of these hurdles and discuss recent experiments that investigate the potential of using neural precursor cells found in the subventricular zone of the adult brain for brain repair.
Lim
Daniel A
DA
Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA.
Flames
Nuria
N
Collado
Lucía
L
Herrera
Daniel G
DG
D000818:Animals; D001921:Brain / Q000166:cytology / Q000254:growth & development* / Q000502:physiology; D016380:Brain Tissue Transplantation / Q000379:methods* / Q000639:trends*; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D020547:Lateral Ventricles / Q000166:cytology / Q000254:growth & development / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000628:therapy*; D009474:Neurons / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology / Q000502:physiology