Applications of derivative UV spectrophotometry for the determinations of cetirizine dihydrochloride in pharmaceutical preparations.
A method for the determination of cetirizine dihydrochloride in pharmaceuticals by first-, second-, third- and fourth- order derivative spectrophotometry is described, using "peak-peak" (P-P), and "peak-zero" (P-0) measurements. The calibration curves are linear within the concentration range of 7.5-22.5 microg ml(-1) for cetirizine dihydrochloride. The procedure is simple, rapid and the results are reliable.
Drozd
Joanna
J
Department of Medicinal Chemistry, Medical University, Lublin, Poland.
Hopkała
Hanna
H
Misztal
Genowefa
G
Paw
Beata
B
D017332:Cetirizine / Q000032:analysis* / Q000737:chemistry; D006634:Histamine H1 Antagonists / Q000032:analysis* / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods / Q000706:statistics & numerical data; D013607:Tablets
D006634:Histamine H1 Antagonists; D004364:Pharmaceutical Preparations; D013607:Tablets; D017332:Cetirizine