Antimicrobial activity of two novel coumarin derivatives: 3-cyanonaphtho[1,2-(e)] pyran-2-one and 3-cyanocoumarin.
The antimicrobial activity of the two novel coumarin derivatives, 3-cyanonaphthol[1,2-(e)]pyran-2-one and 3-cyanocoumarin was determined. The two novel coumarin derivatives showed specific activity against most gram-positive organisms and yeast with lower activity against most gram-negative bacteria. The MIC values of compounds showed that they are largely active against E. coli to a lesser extent against S. aureus and C. albicans.
Zaha
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Amman University, Faculty of Pharmacy and Medical Sciences, Al-Sarw, Jordan.
Hazem
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A
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011753:Pyrones / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
C469959:3-cyanocoumarin; C469958:3-cyanonaphtho(1,2-(e))pyran-2-one; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D003374:Coumarins; D011753:Pyrones; C030123:coumarin