title: [Carcinoid heart disease and primary ovarian tumor].
abstract: Carcinoid heart disease occurs in about one third of patients with carcinoid syndrome, especially in those with ileal carcinoid and hepatic metastases. Patients with primary ovarian carcinoid tumor are extremely rare. In these circumstances, typical carcinoid cardiac lesions may develop unassociated with hepatic metastases, due to the venous drainage from the ovaries into the inferior vena cava of vasoactive released substances such as serotonin. The present report describes a woman with unrecognized primary ovarian carcinoid tumor, unexpectedly exhibiting heart failure. Diagnosis was performed on the basis of echocardiographic findings, occurrence of diarrhea and increased levels of 5-hydroxy-indoleacetic acid (5-HIAA). After complete surgical removal of the tumor, the patient was maintained under therapy with ACE-inhibitors and diuretics. Levels of 5-HIAA are still within normal range, there is regression of heart failure and echocardiographic findings are stabilized. These data confirm the importance of prompt diagnosis for a favorable prognosis of carcinoid heart disease.
authors.affiliation: Dipartimento Medico, U.O. Cardiovascolare, Ospedale Civile ASL 17 Via San Fermo 35042 Este, PD. luciotarga@yahoo.it
authors.forename: Lucio
authors.initials: L
authors.lastname: Targa
authors.forename: Giovanni
authors.initials: G
authors.lastname: Conti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Gabellini
authors.forename: Sante
authors.initials: S
authors.lastname: Bergamo
authors.forename: Alessi
authors.initials: A
authors.lastname: Rossetto
authors.forename: Federico
authors.initials: F
authors.lastname: Corbara
mesh_terms: D002275:Carcinoid Heart Disease / Q000000981:diagnostic imaging*; D002276:Carcinoid Tumor / Q000175:diagnosis* / Q000556:secondary*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D014463:Ultrasonography