title: Drugs, leads, and drug-likeness: an analysis of some recently launched drugs.
abstract: An analysis of the origins of recently launched drugs reveals that most were derived by modification of known drug structures or from lead structures obtained from the scientific literature. High-throughput screening did not have a significant impact on the derivation of these drugs. The drug structures are very closely related to their leads.
authors.affiliation: Boehringer Ingelheim Pharmaceuticals Inc., Department of Medicinal Chemistry, 900 Ridgebury Road, PO Box 368, Ridgefield, CT 06877, USA. jrproudfo@rdg.boehringer-ingelheim.com
authors.forename: John R
authors.initials: JR
authors.lastname: Proudfoot
mesh_terms: D015195:Drug Design; D004355:Drug Stability; D015394:Molecular Structure