Chromosome-encoded class D beta-lactamase OXA-23 in Proteus mirabilis.
Ten nonrepetitive Proteus mirabilis isolates, which were collected over 4 years (1996 to 1999) at the teaching hospital of Clermont-Ferrand, France, produced class D carbapenemase OXA-23. MICs of imipenem were 0.25 to 0.5 microg/ml for these clinical isolates. Molecular typing revealed that the 10 P. mirabilis isolates originated from the same clonal strain. Hybridization of I-CeuI-generated chromosome fragments with a bla(OXA-23) probe showed that the gene was chromosome encoded in the P. mirabilis strain.
Bonnet
R
R
Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex, France. Richard.Bonnet@u-clermont1.fr
Marchandin
H
H
Chanal
C
C
Sirot
D
D
Labia
R
R
De Champs
C
C
Jumas-Bilak
E
E
Sirot
J
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002876:Chromosomes, Bacterial / Q000235:genetics*; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D009693:Nucleic Acid Hybridization; D011513:Proteus mirabilis / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; C466679:beta-lactamase OXA-23; D001618:beta-Lactamases