Antidepressant activity of hyperforin conjugates of the St. John's wort, Hypericum perforatum Linn.: an experimental study.
Nine extracts of H. perforatum, containing hyperforin in conjugated forms, but devoid of free hyperforin and adhyperforin, were subjected to antidepressant screening using the forced swim test (FST). The observed activity was compared with that of SJW extracts containing hyperforin and adhyperforin (in free form). Results indicate that hyperforin conjugates exhibit significant antidepressant activity as evidenced by the reduced immobility period in the FST in rats.
Muruganandam
A V
AV
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Bhattacharya
S K
SK
Ghosal
S
S
D000818:Animals; D000928:Antidepressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds; D005260:Female; D020902:Hypericum / Q000737:chemistry*; D008297:Male; D010696:Phloroglucinol / Q000031:analogs & derivatives; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D013550:Swimming; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*
D000928:Antidepressive Agents; D001643:Bridged Bicyclo Compounds; D010936:Plant Extracts; D013729:Terpenes; D010696:Phloroglucinol; C001654:hyperforin