Evaluation of the clonality of multilobar bronchioloalveolar carcinoma of the lung: case report.
A case of multilobar bronchioloalveolar carcinoma (BAC) is reported. To investigate the clonality of BAC, immunohistochemical staining as well as genetic analysis were performed. To investigate point mutations of the p53 gene, we used the polymerase chain reaction and fluorescence-based single strand conformation polymorphism analysis method. The BAC tissues of the right upper lobe, right lower lobe, and the other lobes were considered to be multiclonal. This case suggests that multilobar BAC might occur with multiclonality.
Nanki
Nobuki
N
First Department of Internal Medicine, Kagawa Medical University, Kochi, Japan.
Fujita
Jiro
J
Hojo
Satoko
S
Yang
Yu
Y
Bandoh
Shuji
S
Ohara
Nobuya
N
Miyatani
Katsuya
K
Yamaji
Yasufumi
Y
Ohtsuki
Yuji
Y
Ishida
Toshihiko
T
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000235:genetics* / Q000473:pathology; D000368:Aged; D016158:Genes, p53; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D009154:Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational