title: Topographic changes in corneal asphericity and effective optical zone after laser in situ keratomileusis.
abstract: OBJECTIVE
  To determine the relationship between the spherical refractive change after myopic excimer laser surgery and the effective optical zone (EOZ) and corneal asphericity determined by corneal topography.
  
  
  METHODS
  Baylor College of Medicine, Houston, Texas, USA.
  
  
  METHODS
  Preoperative and postoperative topographies along with refractions were evaluated in all patients who had had laser in situ keratomileusis since January 1999 and had at least 6 months of follow-up. The VISX Smoothscan S2 excimer laser and the Hansatome microkeratome (Bausch & Lomb) were used in all cases. Because optical zones are oval with astigmatic treatments with the VISX laser, only patients with spherical refractions and treatments were included. Thirty-nine cases met the criteria; their treatments ranged from -1.50 to -18.00 diopters (D). The preoperative and postoperative corneal asphericities (Q-values) were taken directly from the Holladay Diagnostic Summary Report on the EyeSys 2000, version 4.0. The mean diameter of the optical zone was measured on the local radius of curvature map using the outer edge of the yellow zone, which corresponds to 2 color changes or approximately 0.50 D steepening from the mean central radius (green).
  
  
  RESULTS
  The EOZ decreased as the amount of treatment increased. The decrease was slightly nonlinear, decreasing slightly more rapidly at higher treatments. For an "intended" 6.0 mm optical zone, the nominal EOZs from the least-squares second-order polynomial regression were 6.0 mm for -1.5 D, 5.4 mm for -5.0 D, 4.6 mm for -10.0 D, 3.8 mm for -15.0 D, and 3.2 mm for -18.0 D. The least-squares second-order polynomial regression yielded a standard error of the estimate (SEE) of +/- 0.22 mm (R(2) = 0.90). The asphericity increased nonlinearly in a positive direction (oblate) with the amount of treatment, indicating greater amounts of correction produced progressively more oblate corneal surfaces. The least-squares second-order polynomial regression yielded an SEE of +/- 0.42 (R(2) = 0.55).
  
  
  CONCLUSIONS
  The EOZ decreased and the Q-value increased with the amount of myopic excimer laser treatment. The optical zone was approximately 4.3 mm with a spherical treatment of -12.0 D. These findings may explain the clinical studies that indicate high myopic treatments (above -12.0 D) are associated with poor visual outcomes.
authors.affiliation: Baylor College of Medicine, Houston, Texas, USA. holladay@docholladay.com
authors.forename: Jack T
authors.initials: JT
authors.lastname: Holladay
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Janes
mesh_terms: D003315:Cornea / Q000473:pathology* / Q000503:physiopathology*; D019781:Corneal Topography; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D011182:Postoperative Care; D011300:Preoperative Care; D012029:Refraction, Ocular