title: Association study of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease.
abstract: Serotonergic (5-hydroxytryptamine; 5-HT) transmission has been implicated in the pathogenesis of Alzheimer's disease (AD). A coding single nucleotide polymorphism 267 (C/T) in the 5-HT(6) receptor gene was previously reported as a susceptibility factor for AD. An extensive replication study was performed using our data set including sporadic and familial cases. No significant association between the 5-HT(6) receptor gene and AD was obtained with or without the stratification of apolipoprotein E epsilon 4 status. Our result suggests that the 267C allele of the 5-HT(6) receptor gene may not be a genetic risk factor for AD.
authors.affiliation: Laboratorio di Neurogenetica, I.R.C.C.S. Santa Lucia, Via Ardeatina 354, 00179, Rome, Italy. a.orlacchio@hsantalucia.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Orlacchio
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Kawarai
authors.forename: Eleonora
authors.initials: E
authors.lastname: Paciotti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Stefani
authors.forename: Aldo
authors.initials: A
authors.lastname: Orlacchio
authors.forename: Sandro
authors.initials: S
authors.lastname: Sorbi
authors.forename: Peter H
authors.initials: PH
authors.lastname: St George-Hyslop
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bernardi
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000097:blood; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D011985:Receptors, Serotonin / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D011985:Receptors, Serotonin; C097216:serotonin 6 receptor