title: Trisomy 3 in two paediatric post-transplant lymphomas.
abstract: Few cytogenetic data are available concerning the chromosomal constitution of post-transplant lymphomas. We report two paediatric cases of trisomy 3, as a primary anomaly, in post-transplant lymphoproliferative disease (PTLD) associated with B immunophenotype. Using cytogenetic analysis and fluorescence in situ hybridization on chromosome preparations, we found trisomy 3 in both patients and an extra X chromosome in one. Clinical, histological and immunophenotypical data are presented. Trisomy 3 has been observed in different types of non-Hodgkin's lymphomas but it is relatively rare in B-cell lymphomas, with the exception of marginal zone lymphoma and mantle cell lymphoma. To our knowledge, trisomy 3 is an uncommon cytogenetic finding in PTLD. Further cytogenetic studies of these lymphoproliferative disorders might contribute to evaluate the role of these chromosomal anomalies in the pathogenesis of this disease.
authors.affiliation: Cytogenetics Laboratory, Department of Genetics, Prof. Dr. Juan B. Garrahan Pediatric Hospital, Combate de los Pozos 1881, Buenos Aires C.P 1245, Argentina. msgall@intramed.net.ar
authors.forename: Marta S
authors.initials: MS
authors.lastname: Gallego
authors.forename: Andrea
authors.initials: A
authors.lastname: Bernasconi
authors.forename: María T
authors.initials: MT
authors.lastname: Dávila
authors.forename: Alejandra
authors.initials: A
authors.lastname: Rampazzi
authors.forename: Guillermo
authors.initials: G
authors.lastname: Chantada
authors.forename: Guillermo
authors.initials: G
authors.lastname: Gallo
authors.forename: Jorge
authors.initials: J
authors.lastname: Rossi
authors.forename: Cristina Z
authors.initials: CZ
authors.lastname: Barreiro
mesh_terms: D000293:Adolescent; D002893:Chromosomes, Human, Pair 3; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007621:Karyotyping; D016030:Kidney Transplantation; D016031:Liver Transplantation; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000821:virology; D008297:Male; D011183:Postoperative Complications; D014314:Trisomy