title: Role of thrombotic and fibrinolytic disorders in the etiology of Perthes' disease.
abstract: The etiologic role of thrombotic and fibrinolytic disorders in Perthes' disease has not been determined. A case control study was conducted to determine whether thrombotic and fibrinolytic disorders are associated with Perthes' disease. Twenty-six patients with Perthes' disease were matched with 26 control patients for gender, age (2-year range), and time of presentation (1-year range). Thrombotic disorders were investigated for protein C activity, protein S activity, antithrombin III, anticardiolipin antibody immunoglobulins G and M, and lupus anticoagulant. Fibrinolytic disorders were investigated for tissue-plasminogen activator, plasminogen activator inhibitor-1, plasminogen activator inhibitor-1 to tissue plasminogen activator ratio, lipoprotein (a), and plasminogen. The activity of protein C, which suppresses factor Va and leads to an increase of coagulant activity when decreased, was increased in patients. There were no significant differences in the levels of other factors between the patients and controls. No evidence was found to prove a relationship between Perthes' disease and thrombotic or fibrinolytic disorders in the patients in the current study.
authors.affiliation: Department of Orthopaedic Surgery, Institute of Health Sciences, Gyeong-Sang National University School of Medicine, 90 Chilam-dong, Chinju 660-702, South Korea.
authors.forename: Kyung-Hoi
authors.initials: KH
authors.lastname: Koo
authors.forename: Hae-Ryong
authors.initials: HR
authors.lastname: Song
authors.forename: Yong-Chan
authors.initials: YC
authors.lastname: Ha
authors.forename: Jang-Rak
authors.initials: JR
authors.lastname: Kim
authors.forename: Seon-Ju
authors.initials: SJ
authors.lastname: Kim
authors.forename: Kang-I I
authors.initials: KI
authors.lastname: Kim
authors.forename: Ki Churl
authors.initials: KC
authors.lastname: Chang
authors.forename: In-Oak
authors.initials: IO
authors.lastname: Ahn
authors.forename: Se-Hyun
authors.initials: SH
authors.lastname: Cho
mesh_terms: D001778:Blood Coagulation Disorders / Q000150:complications* / Q000175:diagnosis; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D007873:Legg-Calve-Perthes Disease / Q000175:diagnosis / Q000209:etiology*; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D012307:Risk Factors; D013927:Thrombosis / Q000150:complications*; D010959:Tissue Plasminogen Activator / Q000378:metabolism*
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator