Stress-induced premature senescence: from biomarkers to likeliness of in vivo occurrence.
The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of 'molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.
Toussaint
Olivier
O
University of Namur, Unit of Cellular Biochemistry, Belgium. olivier.toussaint@fundp.ac.be
Remacle
José
J
Dierick
Jean-François
JF
Pascal
Thierry
T
Frippiat
Christophe
C
Royer
Véronique
V
Magalhacs
Joao Pedro
JP
Zdanov
Stéphanie
S
Chainiaux
Florence
F
D019588:Aging, Premature / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers; D016207:Cytokines / Q000378:metabolism; D005720:Gamma Rays; D006801:Humans; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress; D014466:Ultraviolet Rays
D015415:Biomarkers; D016207:Cytokines; D016877:Oxidants