title: [Prevalence of Leiden mutation in various gastrointestinal disorders].
abstract: Molecular biological examinations have been carried out by the authors from 1995 in patients with different haemostasis, very recently these types of the studies were done in patients with different gastrointestinal (Helicobacter pylori-induced gastritis, hepatitis C infection, ileitis terminalis, ulcerative colitis, colon polyposis and adenocarcinoma in polyps) disorders.
  The Leiden mutation was detected by polymerase chain reaction (PCR) in 1354 healthy persons and patients with different GI disorders.
  
  
  RESULTS
  The results of Leiden prevalence in patients with different gastrointestinal disorders were compared to those obtained in patients with venous thrombosis and familiar thrombophilia. The authors indicated that the prevalence of heterozygous Leiden positive persons was 5.9% in healthy (n = 87) and blood donors (n = 600). The prevalence of heterozygous Leiden mutation was 27% in patents who under went venous thrombosis (n = 300; P < 0.001), 38% in patients with familial thrombophilia (n = 116; P < 0.001). The prevalence of Leiden mutation was 0 in patients with Helicobacter pylori-induced gastritis (n = 24), 8% in hepatitis C infections (n = 75), 14.28% in Crohn's disease, (n = 49; P < 0.01), 27.5% in ulcerative colitis (n = 35; P < 0.001), 44% in colon polyposis (n = 59; P < 0.001) and 55% in situ adenocarcinomas (in polyposis) (n = 9; P < 0.001).
  
  
  CONCLUSIONS
  The presented results suggest that the Leiden mutation is involved in patients with different inflammatory bowel disease, colon polyposis, as one of the suggested genetic factors.
authors.affiliation: Pécsi Tudományegyetem Altalános Orvostudományi Kar, I. sz. Belgyógyászati Klinika. mozsik@clinics.pote.hu
authors.forename: Gyula
authors.initials: G
authors.lastname: Mózsik
authors.forename: Mária
authors.initials: M
authors.lastname: Figler
authors.forename: Beáta
authors.initials: B
authors.lastname: Gasztonyi
authors.forename: Oszkár
authors.initials: O
authors.lastname: Karádi
authors.forename: Hajna
authors.initials: H
authors.lastname: Losonzy
authors.forename: Agnes
authors.initials: A
authors.lastname: Nagy
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Nagy
authors.forename: Alajos
authors.initials: A
authors.lastname: Pár
authors.forename: György
authors.initials: G
authors.lastname: Rumi
authors.forename: Gábor
authors.initials: G
authors.lastname: Sütó
authors.forename: Aron
authors.initials: A
authors.lastname: Vincze
mesh_terms: D003111:Colonic Polyps / Q000235:genetics; D005164:Factor IX / Q000235:genetics*; D005767:Gastrointestinal Diseases / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics; D009154:Mutation; D015995:Prevalence; D019851:Thrombophilia / Q000235:genetics; D020246:Venous Thrombosis / Q000235:genetics
chemical_list: C064567:factor IX Leyden; D005164:Factor IX