title: [Synthesis of spin labeled analogue of podophyllotoxin glycoside].
abstract: A novel spin labeled analogue of podophyllotoxin glycoside 9 was synthesized by condensing 4'-demthyl-epipodophyllotoxin-beta-D-glucopyranose and 4-formyl-2, 2, 6, 6-tetrahydropuridine in presence of p-TsOH and triethyl orthoformate. It was shown to exhibit activity compatible to VP-16-213 in inhibiting L1210 cells.
authors.affiliation: Institute of Applied Pharmaceutical Research, Beijing Medical University, Beijing 100083.
authors.forename: K
authors.initials: K
authors.lastname: Lu
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D013113:Spin Labels; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013113:Spin Labels; D011034:Podophyllotoxin