title: [A case of rectal cancer with multiple liver metastases that responded dramatically to pharmacokinetic modulating chemotherapy/CPT-11 therapy].
abstract: A 67-year-old male patient suffering from rectal cancer complicated by multiple hepatic metastases underwent low anterior resection, cholecystectomy and hepatic arterial cannulation. He was treated postoperatively with arterial infusion pharmacokinetic modulating chemotherapy (PMC) and venous infusion CPT-11 (modified PMC). After three courses of modified PMC, a complete response (CR) of the hepatic metastatic lesions was noted. PMC/CPT-11 therapy was managed at our outpatient clinic, and seems to be a useful treatment option.
authors.affiliation: Dept. of Surgery, Takarazuka Municipal Hospital.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Matsusaka
authors.forename: Hajime
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kitayama
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Okada
authors.forename: Shigeto
authors.initials: S
authors.lastname: Maeda
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Dan
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kosaka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tanabe
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage* / Q000031:analogs & derivatives; D006499:Hepatic Artery; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
chemical_list: D005641:Tegafur; D014498:Uracil; D000077146:Irinotecan; D002166:Camptothecin