title: Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate.
abstract: Ethoxyethanol is an ether alcohol described as a solvent and viscosity-decreasing agent for use in cosmetics. Ethoxyethanol Acetate is the ester of Ethoxyethanol and acetic acid described as a solvent for use in cosmetics. Although these ingredients have been used in the past, neither ingredient is in current use. Ethoxyethanol is produced by reacting ethylene oxide with ethyl alcohol. Ethoxyethanol Acetate is produced via an esterification of Ethoxyethanol and acetic acid, acetic acid anhydride, or acetic chloride. Ethoxyethanol is metabolized to ethoxyacetaldehyde, which is further metabolized to ethoxyacetic acid, which is also a metabolite of Ethoxyethanol Acetate. Low to moderate acute inhalation toxicity is seen in animals studies. Acute oral toxicity studies in several species reported kidney damage, including extreme tubular degeneration. Kidney damage was also seen in acute dermal toxicity studies in rats and rabbits. Minor liver and kidney damage was also seen in short-term studies of rats injected subcutaneously with Ethoxyethanol, but was absent in dogs dosed intravenously. Mixed toxicity results were also seen in subchronic tests in mice and rats. Ethoxyethanol and Ethoxyethanol Acetate were mild to moderate eye irritants in rabbits; mild skin irritants in rabbits, and nonsensitizing in guinea pigs. Most genotoxicity tests were negative, but chromosome aberrations and sister-chromatid exchanges were among the positive results seen. Numerous reproductive and developmental toxicity studies, across several species, involving various routes of administration, indicate that Ethoxyethanol and Ethoxyethanol Acetate are reproductive toxicants and teratogens. Mild anemia was reported in individuals exposed occupationally to Ethoxyethanol, which resolved when the chemical was not used. Reproductive effects have been noted in males exposed occupationally to Ethoxyethanol. Although there are insufficient data to determine the potential carcinogenic effects of Ethoxyethanol or Ethoxyethanol Acetate, there is evidence that these chemicals are absorbed across human skin and that they are reproductive and developmental toxicants via dermal exposure. Therefore, these ingredients are unsafe for use in cosmetic formulations.
authors.affiliation: Cosmetic Ingreient Review, Washington, DC 20036, USA.
authors.forename: Wilbur
authors.initials: W
authors.lastname: Johnson
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D003257:Consumer Product Safety; D003358:Cosmetics / Q000009:adverse effects* / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D005026:Ethylene Glycols / Q000009:adverse effects* / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D012869:Skin Absorption; D018675:Toxicity Tests
chemical_list: D003358:Cosmetics; D005026:Ethylene Glycols; C022278:ethylene glycol monoethyl ether acetate; C021296:2-ethoxyethanol