Development of tripeptidyl farnesyltransferase inhibitors.
The first example of tripeptide inhibitors of farnesyltransferase with sub-micromolar inhibition activity was developed based on the fact that CVFM is not a substrate for farnesyltransferase.
Lee
Hee-Yoon
HY
Center for Molecular Design and Synthesis, Department of Chemistry and School of Molecular Science(BK21), Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea. leehy@kaist.ac.kr
Sohn
Jeong-Hun
JH
Kwon
Byoung-Mog
BM
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000595:Amino Acid Sequence; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051231:Farnesyltranstransferase; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D009842:Oligopeptides; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase