Propofol reduces spinal motor neuron excitability in humans.
We investigated in humans whether changes in spinal motor neuron excitability correlate with the predicted propofol concentration (Cpt) achieved by a target-controlled infusion system. Propofol suppressed F-wave persistence in a Cpt-dependent manner, indicating that propofol depresses spinal motor neuron excitability at clinically relevant concentrations.
Kakinohana
Manabu
M
Division of Anesthesia, Okinawa Prefectural Miyako Hospital, Okinawa, Japan. mnb-shk@ryukyu.ne.jp
Fuchigami
Tatsuya
T
Nakamura
Seiya
S
Kawabata
Tetsuya
T
Sugahara
Kazuhiro
K
D000328:Adult; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000166:cytology / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects*; D019635:Neurosurgical Procedures; D015742:Propofol / Q000008:administration & dosage; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects*
D018686:Anesthetics, Intravenous; D015742:Propofol