Genetic abnormalities in oligodendroglial and ependymal tumours.
Oligodendroglial and ependymal tumours are not the most common glial neoplasms; however, they are important subtypes of gliomas with different tumour biologies. Cytogenetic information has suggested that losses of chromosomes 1 p and 19 q are the most frequent genetic alterations in oligodendroglial tumours. Combined loss of these chromosomes has been associated with better chemotherapeutic response and prolonged overall survival. Loss of chromosome 22 is a well defined abnormality in ependymomas. In addition, deletion of chromosome 6 q may be another frequent chromosomic aberration in paediatric ependymomas.
Goussia
A C
AC
Department of Pathology, University of Ioannina, School of Medicine, Greece.
Kyritsis
A P
AP
Mitlianga
P
P
Bruner
J M
JM
D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002875:Chromosomes / Q000235:genetics / Q000648:ultrastructure; D004806:Ependymoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D009837:Oligodendroglioma / Q000235:genetics* / Q000473:pathology