Cholestatic fibrosing hepatitis and hepatitis B after bone marrow transplantation.
In the setting of transplantation and chronic hepatitis B viral infection there is a unique histological feature termed cholestatic fibrosing hepatitis. The use of nucleoside analogues in the treatment of this condition has been successful. We describe a case of cholestatic fibrosing hepatitis, which occurred after intense immunosuppression for graft versus host disease in a patient with bone marrow transplantations. She was commenced on lamivudine therapy and showed good clinical, biochemical and virological response. However she succumbed due to sepsis.
Suresh
R L
RL
Department of Medicine, Hospital Kuala Lumpur.
Merican
I
I
Chang
K M
KM
Yong
S M
SM
Purusothaman
V
V
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002779:Cholestasis / Q000209:etiology*; D005260:Female; D006505:Hepatitis / Q000209:etiology*; D006509:Hepatitis B / Q000209:etiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology*