title: Regulation of B-cell signal transduction by adaptor proteins.
abstract: An important role has emerged for adaptor molecules in linking cell-surface receptors, such as the B-cell antigen receptor, with effector enzymes. Adaptor proteins direct the appropriate subcellular localization of effectors and regulate their activity by inducing conformational changes, both of which, in turn, contribute to the spatio-temporal precision of B-cell signal-transduction events. In addition, adaptor molecules participate in establishing negative- or positive-feedback regulatory loops in signalling networks, thereby fine-tuning the B-cell response.
authors.affiliation: Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Japan. kurosaki@mxr.mesh.ne.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kurosaki
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002352:Carrier Proteins / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D021962:Membrane Microdomains / Q000378:metabolism; D008565:Membrane Proteins / Q000502:physiology; D018448:Models, Immunological; D010716:Phosphatidylinositols / Q000378:metabolism; D010750:Phosphoproteins / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C113939:B cell linker protein; D002352:Carrier Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C408344:Pag protein, mouse; D010716:Phosphatidylinositols; D010750:Phosphoproteins; D011947:Receptors, Antigen, B-Cell; D011505:Protein-Tyrosine Kinases