EDTA-dependent pseudothrombocytopenia confirmed by supplementation of kanamycin; a case report.
EDTA-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to EDTA-induced aggregation of platelets. Since the failure to recognize EDTA-dependent PTCP may result in incorrect diagnosis and inappropriate treatment, the recognition of this phenomenon is very important. We report an insidious case of EDTA-dependent PTCP confirmed by supplementation of kanamycin to anticoagulant in a 53-year-old women. Although sodium citrate and heparin usually prevented the aggregation of platelets in EDTA-dependent PTCP patients, these anticoagulants failed in preventing PTCP in our case. EDTA-dependent PTCP was confirmed by the findings that the clumping of platelets on microscopic evaluation was found in EDTA-anticoagulated blood samples, whereas thrombocytopenia and platelet aggregation were not revealed in the sample supplemented with kanamycin.
Ahn
Hae Lyun
HL
Department of Internal Medicine, Konkuk University College of Medicine, Seoul, Korea.
Jo
Young Il
YI
Choi
Young Suk
YS
Lee
Jung Yeon
JY
Lee
Hae Woon
HW
Kim
Seong Ryul
SR
Sim
Joon
J
Lee
Weon
W
Jin
Chun Jo
CJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000925:Anticoagulants / Q000009:adverse effects* / Q000494:pharmacology; D004492:Edetic Acid / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007612:Kanamycin / Q000494:pharmacology*; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010976:Platelet Count; D013921:Thrombocytopenia / Q000097:blood* / Q000139:chemically induced
D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D007612:Kanamycin; D004492:Edetic Acid