title: Clinicopathologic features, diagnosis, and treatment of fibrosarcoma of bone.
abstract: Fibrosarcoma of bone is a relatively rare tumor; it accounts for less than 5% of bone sarcomas. The anatomical sites most commonly involved are the metaphyses of long tubular bones. Local pain, swelling, limitation of motion, and pathologic fracture are the common clinical signs and symptoms. Typical imaging findings include eccentrically located lytic lesions, with a geographic, moth-eaten, or permeative pattern of bone destruction, and extension into adjacent soft tissues. Surgery is the treatment of choice. The type of surgical procedure depends mainly on histologic grade, local conditions, and tumor location. With a high probability of metastases (>70%) after surgical treatment, perioperative adjuvant treatment modalities should be considered for high-grade tumors. The most important prognostic factors affecting survival include tumor grade, patient's age, and tumor location.
authors.affiliation: Department of Orthopedics, Athens University Medical School, Greece.
authors.forename: Panayiotis J
authors.initials: PJ
authors.lastname: Papagelopoulos
authors.forename: Evanthia C
authors.initials: EC
authors.lastname: Galanis
authors.forename: Pantelis
authors.initials: P
authors.lastname: Trantafyllidis
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Boscainos
authors.forename: Franklin H
authors.initials: FH
authors.lastname: Sim
authors.forename: K Krishnan
authors.initials: KK
authors.lastname: Unni
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005354:Fibrosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D011379:Prognosis