The SWIB and the MDM2 domains are homologous and share a common fold.
Using a novel algorithm for protein sequence/structure analysis, we propose a probable homology between the SWIB domain (the conserved domain of the 60 kda subunit of the SWIB complex involved in chromatin remodelling) and the p53-binding domain of the MDM2 oncoprotein. The homology suggests that the SWIB domain would adopt a structure similar to that of the MDM2 domain and that these two families of proteins may share a similar functional mechanism.
Bennett-Lovsey
Riccardo
R
Department of Biochemistry, University of Cambridge, Old Addenbrookes Site, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
Hart
Sarah E
SE
Shirai
Hiroki
H
Mizuguchi
Kenji
K
D000465:Algorithms; D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D002689:Chlamydia / Q000235:genetics; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry* / Q000235:genetics*; D030562:Databases, Protein; D016158:Genes, p53 / Q000235:genetics; D016680:Genome, Bacterial; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009317:National Library of Medicine (U.S.); D009687:Nuclear Proteins; D011487:Protein Conformation; D017510:Protein Folding; D011518:Proto-Oncogene Proteins / Q000737:chemistry* / Q000235:genetics*; D051736:Proto-Oncogene Proteins c-mdm2; D016415:Sequence Alignment / Q000379:methods*; D017385:Sequence Homology; D014157:Transcription Factors / Q000737:chemistry* / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000235:genetics; D014481:United States
D001425:Bacterial Outer Membrane Proteins; D002868:Chromosomal Proteins, Non-Histone; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; C445179:SWI-SNF-B chromatin-remodeling complex; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; C067562:protein 60K, Chlamydia trachomatis; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2