Successful treatment for leg ulcers due to hydroxyurea in a patient with chronic myelogenous leukaemia.
A 51-year-old male who had intractable leg ulcers during treatment for chronic myelogenous leukaemia with hydroxyurea (HU) is reported. His leg ulcers were treated by application of tretinoin tocoferil (TT) ointment after surgical debridement; good results were obtained. Although stopping HU administration is vitally important, surgical debridement and TT application are effective for treating leg ulcers due to HU.
Kawabata
H
H
Department of Haematology, Imamura Bun-in Hospital, Kagoshima, Japan.
Kamada
T
T
Takatsuka
Y
Y
Takeuchi
S
S
Suzuki
S
S
Makino
T
T
Utsunomiya
A
A
D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003646:Debridement; D004338:Drug Combinations; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects* / Q000627:therapeutic use; D007871:Leg Ulcer / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009824:Ointments; D014212:Tretinoin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D004338:Drug Combinations; D009824:Ointments; D014810:Vitamin E; D014212:Tretinoin; C089853:tocoretinate; D006918:Hydroxyurea