title: [Treatment of HIV infection from the neurologic viewpoint. Therapy must reach the brain].
abstract: An effective highly active antiretroviral therapy (HAART) can prevent the manifestation of HIV-1-associated encephalopathy. Also, HIV-1-associated minor cognitive/motor deficits--an early form of HIV-1-associated dementia--are improved. Clinically manifest HIV-1-associated encephalopathy is an indication for HAART treatment, irrespective of immune status. To date, minor cognitive and/or motor deficits in the presence of good immune status have not been identified as an indication for HAART treatment. Any CNS-effective treatment should be based on either zidovudine or stavudine, since these substances readily enter the CSF; however, NNRTI can also be applied. Side effects of HAART on the central and peripheral nervous system, as well as interactions with known neurological medicaments must be taken into account.
authors.affiliation: Neurologische Klinik des Universitätsklinikums, Heinrich-Heine-Universität Düsseldorf. giesenhj@uni-duesseldorf.de
authors.forename: H J
authors.initials: HJ
authors.lastname: von Giesen
authors.forename: H
authors.initials: H
authors.lastname: Köller
authors.forename: G
authors.initials: G
authors.lastname: Arendt
mesh_terms: D015526:AIDS Dementia Complex / Q000097:blood / Q000188:drug therapy*; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents