title: Calcified vestibular schwannoma with unusual histological characteristics - positive immunoreactivity for CD-34 antigen.
abstract: Calcification in vestibular schwannoma is extremely rare. A 36-year-old man presented with a history of decreased hearing on the left since childhood. Computed tomography showed a left cerebellopontine angle lesion protruding into the porus acousticus and enlarging the internal auditory meatus, with significant deposits of calcification. Histological and immunohistochemical examination, including staining for CD-34, a myeloid progenitor cell antigen, found highly degenerated schwannoma with collagen-rich tissue, calcification, formation of bone, abnormal vessels of various sizes, and old haemorrhage with marked haemosiderin-laden macrophages. Most of the surgical specimen was sclerotic collagenous tissue containing sparse spindle-shaped cells which formed approximately 90% of the total specimen. However, the spindle-shaped cells were partly concentrated into islands forming the cellular part (approximately 10% of the total). The spindle-shaped cells in both parts showed almost typical immunohistochemical characteristics of schwannoma. However, many spindle-shaped cells in only the sclerotic part were positive for CD-34, which is widely used for the diagnosis of solitary fibrous tumours. Cerebellopontine angle tumour showing fibromatous tissue, including calcification, may contain foci of typical schwannoma. Careful histological examination with detailed immunohistochemical staining is required for the correct diagnosis. In particular, spindle-shaped cells occasionally show positive immunoreactivity for CD-34 antigen in the areas of degenerated and calcified schwannoma characteristic of our case.
authors.affiliation: Department of Neurosurgery, Gunma University School of Medicine, Maebashi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tosaka
authors.forename: J
authors.initials: J
authors.lastname: Hirato
authors.forename: T
authors.initials: T
authors.lastname: Miyagishima
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Nakazato
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis*; D002114:Calcinosis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009464:Neuroma, Acoustic / Q000276:immunology* / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014722:Vestibule, Labyrinth / Q000473:pathology*
chemical_list: D018952:Antigens, CD34