Collagenous spherulosis in epithelial-myoepithelial carcinoma of the parotid gland. Histological and immunohistological study of a case.
Previously unreported histological and immunohistochemical features of collagenous spherulosis in an epithelial-myoepithelial carcinoma found in an 80-year-old woman are described. The multinodular tumor located in the right parotid gland was completely removed surgically. No local recurrence of the tumor appeared during the 22-month period of periodic checkups. This is believed to be the first report on collagenous spherulosis in an epithelial-myoepithelial carcinoma of the salivary gland. Different immunohistochemical characteristics of epithelial and myoepithelial neoplastic cells were found very useful for their analysis namely in parts of the tumor where one cell type greatly predominated (e.g. clear cell-type predominance). The double staining of histological sections can in this sense be recommended for the differentiation from other clear cell tumors of salivary glands allowing the correct categorization of the neoplasm.
Böor
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Institute of Pathology, Faculty of Medicine, P.J. Safárik University in Kosice, Slovak Republic.
Jurkovic
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Kocan
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P
Jenca
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D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000737:chemistry* / Q000378:metabolism* / Q000473:pathology; D003094:Collagen / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009208:Myoepithelioma / Q000737:chemistry* / Q000378:metabolism* / Q000473:pathology; D010307:Parotid Neoplasms / Q000737:chemistry* / Q000378:metabolism* / Q000473:pathology; D018874:Spheroids, Cellular / Q000737:chemistry* / Q000378:metabolism* / Q000473:pathology
D003094:Collagen