Methyl 2-((succinimidooxy)carbonyl)benzoate (MSB): a new, efficient reagent for N-phthaloylation of amino acid and peptide derivatives.
A new, efficient, and readily available reagent, methyl 2-((succinimidooxy)carbonyl)benzoate (MSB), for N-phthaloylation of amino acids and amino acid derivatives is described. The phthaloylation procedure is simple and racemization-free and gives excellent results with alpha-amino acids, alpha-amino alcohols, dipeptides, alpha-amino carboxamides, and alpha-amino esters.
Casimir
J Richard
JR
Laboratoire d'Immunologie et Chimie Thérapeutique, UPR 9021 CNRS, IBMC, 15 rue René Descartes, F-67084 Strasbourg Cedex, France. casimir.richard@wanadoo.fr
Guichard
Gilles
G
Briand
Jean-Paul
JP
D000596:Amino Acids / Q000138:chemical synthesis*; D001565:Benzoates / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis*; D010795:Phthalic Acids / Q000737:chemistry*; D013388:Succinimides / Q000737:chemistry*
D000596:Amino Acids; D001565:Benzoates; C467959:Methyl 2-((succinimidooxy)carbonyl)benzoate; D010455:Peptides; D010795:Phthalic Acids; D013388:Succinimides