title: Clinical application of injectable calcium sulfate on early bony consolidation in distraction osteogenesis for the treatment of craniofacial microsomia.
abstract: The purpose of this project was to study the effect of calcium sulfate on early bony consolidation in distraction osteogenesis. A total of eight patients with craniofacial microsomia were treated between April 2000 and February 2001. The age of the patients ranged from 2 to 40 years, and all were male. The follow-up period was 1 to 15 months. The operative procedure in adults was based on Ortiz Monasterio's simultaneous mandibular and maxillary distraction technique. In children, osteotomy of the mandible was performed for distraction. On the fifth day after the operation, distraction was performed at a rate of 1 mm/d in three adults. In children, distraction was performed at a rate of 1 mm/d in one patient and 2 mm/d in four patients without a latent period. On the day of completion of distraction, calcium sulfate was implanted into the distracted zone. Radiographs showed bony consolidation at 4 weeks in one child at a rate of 1 mm/d, at 5 to 7 weeks in four children at a rate of 2 mm/d, and at 5 weeks in three adults after implantation of the calcium sulfate. In conclusion, these findings suggest that calcium sulfate is effective for early bony consolidation in distraction osteogenesis and that it would shorten the whole treatment period.
authors.affiliation: From the Department of Plastic and Reconstructive Surgery, School Of Medicine, Kyungpook National University, Samduk 2 ga, 50, Taegu, 700-721, Korea. bccho@knu.ac.kr
authors.forename: Byung Chae
authors.initials: BC
authors.lastname: Cho
authors.forename: Jae Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Baik
authors.forename: In San
authors.initials: IS
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000627:therapeutic use*; D002113:Calcification, Physiologic / Q000187:drug effects; D002133:Calcium Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*; D002266:Carboxymethylcellulose Sodium; D002508:Cephalometry; D002648:Child; D002675:Child, Preschool; D005146:Facial Asymmetry / Q000601:surgery*; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D007267:Injections; D008297:Male; D008334:Mandible / Q000601:surgery*; D008437:Maxilla / Q000601:surgery*; D019857:Osteogenesis, Distraction / Q000379:methods*; D010027:Osteotomy / Q000379:methods; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D005782:Gels; D002266:Carboxymethylcellulose Sodium; D002133:Calcium Sulfate