title: Functional residual capacity (FRC) does not predict response to surfactant in preterm infants.
abstract: We tested the hypothesis that the initial functional residual capacity (FRC) of preterm infants with hyaline membrane disease (HMD) could predict the response to surfactant replacement (Survanta, 4 mL/kg/dose), with a better initial FRC being correlated with a greater improvement in PaO2, a/A PO2 ratio, and FRC. Thirty-four preterm infants were studied on 41 occasions. FRC and arterial blood gases were measured immediately prior to treatment. FRC was measured by the helium dilution method. Arterial blood gases were measured again after 30, 60, and 120 minutes. FRC was measured after 120 minutes. Twenty-seven treatments resulted in an increase in PaO2 >10 mmHg (responders); 14 did not (nonresponders). There was no correlation between initial FRC, change in FRC, and change in PaO2 (r2 = 0.07). These results suggest that there is no relationship between initial FRC and response to surfactant treatment.
authors.affiliation: Perinatology Center, Department of Pediatrics, New York Hospital-Cornell Medical Center, New York, New York 10021, USA.
authors.forename: Mariette
authors.initials: M
authors.lastname: Dermendjian
authors.forename: Swati
authors.initials: S
authors.lastname: Varma
authors.forename: Alfred N
authors.initials: AN
authors.lastname: Krauss
authors.forename: Peter A M
authors.initials: PA
authors.lastname: Auld
mesh_terms: D001688:Biological Products; D001784:Blood Gas Analysis; D004305:Dose-Response Relationship, Drug; D005260:Female; D005652:Functional Residual Capacity / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood / Q000502:physiology*; D008168:Lung / Q000187:drug effects*; D008297:Male; D011237:Predictive Value of Tests; D011663:Pulmonary Surfactants / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D001688:Biological Products; D011663:Pulmonary Surfactants; C072197:beractant