title: [Morphological changes in rat liver in toxic drug-induced hepatitis and stimulation of repair processes].
abstract: Despite a large choice of drugs used for the treatment of chronic liver diseases, they often give only a temporary positive effect. In this study the effect of ursodeoxycholic acid on liver regeneration was investigated using the animal model of toxic hepatitis induced by anticonvulsive drug depackin, which is employed in infant neurology. The results of the study demonstrate stimulatory effect of ursodeoxycholic acid on regeneration process in animals' damaged liver, therefore its use may be recommended for the complex treatment of patients with toxic liver lesions.
authors.affiliation: Departments of Biology and Pediatrics, Nizhniy Novgorod State Medical Academy.
authors.forename: V V
authors.initials: VV
authors.lastname: Sadovnikova
authors.forename: I V
authors.initials: IV
authors.lastname: Sadovnikova
authors.forename: N L
authors.initials: NL
authors.lastname: Ivanova
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D008115:Liver Regeneration; D051381:Rats; D014580:Ursodeoxycholic Acid / Q000633:toxicity*
chemical_list: D014580:Ursodeoxycholic Acid