A novel human gene whose product shares homology with bovine brain-specific protein p25 is expressed in fetal brain but not in adult brain.
We have cloned a novel human gene ( C14orf5) from a fetal brain cDNA library that is located on chromosome 14 and consists of 4 exons. It encodes a protein of 170 amino acids that shares homology with human p25 alpha and bovine p25. Reverse transcription-polymerase chain reaction analysis indicated that it is highly expressed in liver and pancreas. Its transcripts could not be detected in adult brain but could be found in fetal brain.
Zhang
Zhen
Z
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P. R. China.
Wu
ChaoQun
C
Huang
Wei
W
Wang
Shu
S
Zhao
EnPeng
E
Huang
QingShan
Q
Xie
Yi
Y
Mao
YuMin
Y
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism; D002417:Cattle; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D003001:Cloning, Molecular; D017931:DNA Primers; D005091:Exons; D005333:Fetus / Q000378:metabolism; D015723:Gene Library; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D017931:DNA Primers; D009419:Nerve Tissue Proteins; C118136:TPPP protein, human