title: CNS stem cell transplantation: clinical and ethical perspectives.
abstract: Central nervous system disorders evoke special fear though their varied and unrelenting threats to memory, cognition, mobility, and every aspect of personal integrity and independence. Understandably, neurologic patients and their families become desperate for help, making fully free, informed consent problematic but not impossible. This desperation mandates our anticipatory attention to ethical questions related to any aggressive new therapy, including central nervous system grafting. In the United States, the right-to-life issue dominates ethical discussions on neural grafting. A variety of alternative tissue sources may permit technically suitable preparations, at least for some uses. If plentiful supplies of grafting cells can be made commercially, this should reduce problems related to allocating scarce resources, although financial and other scarcity barriers may still raise ethical problems. Many contemporary conceptions of selfhood depend on the identity and intactness of the mind and, by implication, the brain as substrate of mind. How much can we reweave the cerebral tapestry without creating a new self, a new identity? These philosophical questions will probably be approached pragmatically and incrementally, in the context of many other developments in human genetics and biomedicine. Our vision of the self will evolve amidst conflicting religious, ethical and pragmatic perspectives.
authors.affiliation: Section of Neurology, Scripps-Mercy Hospital and Department of Neurosciences, UCSD School of Medicine, San Diego, CA, USA.
authors.forename: James Santiago
authors.initials: JS
authors.lastname: Grisolía
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016380:Brain Tissue Transplantation / Q000009:adverse effects* / Q000331:legislation & jurisprudence / Q000523:psychology*; D028663:Ethical Theory; D016332:Fetal Tissue Transplantation / Q000331:legislation & jurisprudence; D006801:Humans; D019636:Neurodegenerative Diseases / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy*; D011603:Psychophysiology; D033581:Stem Cell Transplantation