The role of heme oxygenase signaling in various disorders.
Modern methods of cell and molecular biology, augmented by molecular technology, have great potential for helping to unravel the complex mechanisms of various diseases. They also have the potential to help us try to dissect the events which follow the altered physiological conditions. Thus, there is every reason to believe that some of the potential mechanisms will be translated sooner or later into the clinic. Heme oxygenase (HO)-related mechanisms play an important role in several aspects of different diseases. In the past several years, significant progress has been made in our understanding of the function and regulation of HO. The objective of this article is to review current knowledge relating to the importance of HO mechanism in various diseases including myocardial ischemia/reperfusion, hypertension, cardiomyopathy, organ transplantation, endotoxemia, lung diseases, and immunosuppression. The morbidity and mortality of these diseases remain high even with optimal medical management. Furthermore, in this review, we consider various factors influencing the HO system and finally assess current pharmacological approaches to their control.
Tosaki
Arpad
A
Department of Pharmacology, School of Medicine, Faculty of Pharmacy, University of Debrecen, Hungary. tosaki@king.pharmacol.dote.hu
Das
Dipak K
DK
D000818:Animals; D002318:Cardiovascular Diseases / Q000201:enzymology* / Q000378:metabolism; D019446:Endotoxemia / Q000201:enzymology* / Q000378:metabolism; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D006801:Humans; D007165:Immunosuppression Therapy; D008171:Lung Diseases / Q000201:enzymology* / Q000378:metabolism; D015398:Signal Transduction
D006419:Heme Oxygenase (Decyclizing)