title: Effect of acerola cherry extract on cell proliferation and activation of ras signal pathway at the promotion stage of lung tumorigenesis in mice.
abstract: The present study was undertaken to estimate the effect of acerola cherry extract (ACE) pretreatment on cell proliferation and the activation of Ras signal pathway at a promotion stage of lung tumorigenesis in mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Pretreatment with ACE (dose, 70mg/kg body weight and 700 mg/kg body weight) inhibited increases in the levels of proliferating nuclear cell antigen and ornithine decarboxylase at the promotion stage. This treatment of ACE also suppressed the activation of Ras signal pathway at the same stage. These results suggest that ACE regulates abnormal cell growth at the promotion stage of lung tumorigenesis in mice treated with NNK as a result of suppression of the initiation stage.
authors.affiliation: Department of Agriculture and Biological Chemistry, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Nagamine
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Akiyama
authors.forename: Motoomi
authors.initials: M
authors.lastname: Kainuma
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kumagai
authors.forename: Haruna
authors.initials: H
authors.lastname: Satoh
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamada
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Yano
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Sakurai
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage*; D002455:Cell Division / Q000187:drug effects; D003720:Densitometry; D004586:Electrophoresis; D005260:Female; D015151:Immunoblotting; D008175:Lung Neoplasms / Q000188:drug therapy*; D029581:Malpighiaceae; D051379:Mice; D009602:Nitrosamines / Q000008:administration & dosage*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism*
chemical_list: D002273:Carcinogens; D009602:Nitrosamines; D010936:Plant Extracts; D018809:Proliferating Cell Nuclear Antigen; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; D016283:Proto-Oncogene Proteins p21(ras)