Primary cutaneous plasmacytoma: a clinicopathological study of two cases with a long-term follow-up and review of the literature.
BACKGROUND
Primary cutaneous plasmacytoma (PCP) is a rare type of cutaneous B-cell lymphoma arising primarily in the skin and derived from clonally expanded plasma cells with a various degrees of maturation and atypia. The disease is rare with only 30 cases reported so far.


METHODS
Two cases of PCP with long-term follow-up of 17 and 15 years are presented.


CONCLUSIONS
Both patients were men with nodular lesions on the face. Histologically, the lesions were composed predominantly of variably maturated plasma cells with monotypic expression of immunoglobulin (Ig) lambda chains. Polymerase chain reaction for IgH genes did not reveal clonal rearrangement. Our cases are discussed in the context of previously reported cases of PCP with a long-term follow-up. We also include a review of all cases of PCP with known tumor progression earlier in the course of the disease (local relapse or visceral spread) to determine the clinical course of this primary cutaneous lymphoma.
Kazakov
Dmitry V
DV
Department of Dermatology, University Hospital, Zürich, Switzerland.
Belousova
Irena E
IE
Müller
Beatrix
B
Palmedo
Gabriele
G
Samtsov
Alexey V
AV
Burg
Günter
G
Kempf
Werner
W
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010954:Plasmacytoma / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D016133:Polymerase Chain Reaction; D011447:Prospidium / Q000627:therapeutic use; D011878:Radiotherapy; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D011447:Prospidium