[Effects of riboxin, essentiale, and phylloquinone on the immunomodulating and antioxidant effect of laser and magneto-laser irradiation in liver toxicosis induced by gentamycin].
The introduction of gentamycine to Wistar rats leads to the toxic liver damage, suppresses humoral immune response to goat erythrocytes, and induces immunosuppressant properties in erythrocytes (caused by increased lipid peroxidation in their membranes and violated cell energy balance) Under these conditions, a combination of the laser or magneto-laser irradiation with the administration of phylloquinone of riboxin provides for a more effective correction of the immune reaction and antioxidant status as compared to the radiation treatment without drugs or with essential. Elimination of the gentamycine induced immunosuppressant properties of erythrocytes is explained by the ability of phylloquinone and essential to reduce the intensity of lipid peroxidation in the cell membranes and with the ability of riboxin to normalize the cell energy balance. An important factor of immunosuppression development in the case of a toxic liver damage caused by D-galactosamine it the interaction of thrombocytes and light erythrocytes with serum factors. The introduction of essential and riboxin favors this interaction and stimulates the development of immunosuppression in thrombocytes.
Konoplia
N A
NA
Biochemistry Department, Kursk State Medical University, ul. K. Marksa 3a, Kursk, 305033 Russia.
Prokopenko
L G
LG
Uteshev
B S
BS
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000209:etiology / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology / Q000378:metabolism; D005839:Gentamicins; D007290:Inosine Diphosphate / Q000627:therapeutic use*; D015227:Lipid Peroxidation; D028022:Low-Level Light Therapy; D008280:Magnetics; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D011839:Radiation, Ionizing; D051381:Rats; D017208:Rats, Wistar; D010837:Vitamin K 1 / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D000975:Antioxidants; D005839:Gentamicins; D010713:Phosphatidylcholines; C011246:essential 303 forte; D010837:Vitamin K 1; D007290:Inosine Diphosphate