Inhibition of alpha-glucosidase by oleanolic acid and its synthetic derivatives.
Oleanolic acid (1) and five synthetic derivatives (2-6) were tested spectrophotometrically for inhibition of urease, beta-lactamase, acetyl cholinesterase and alpha-glucosidase. All products showed a positive response only against alpha-glucosidase but not against the other enzymes; IC(50) calculations showed that the dihydroxy-olide derivative (4) was the most potent among all tested samples.
Ali
Muhammad Shaiq
MS
H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan. shaiq303@hotmail.com
Jahangir
Muhammad
M
Hussan
Syed Shazad ul
SS
Choudhary
Muhammad Iqbal
MI
D019659:Asteraceae / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D009828:Oleanolic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D065089:Glycoside Hydrolase Inhibitors; D009828:Oleanolic Acid