title: Effect of dietary linoleic acid on the progression of chronic renal failure in rats.
abstract: The role of linoleic acid in chronic renal failure (CRF) is controversial. In the present study 21 male Wistar rats submitted to 5/6 renal mass reduction (R) and 16 normal controls (C) were fed a supplement (S) or normal (N) linoleic acid diet for 60 days starting 10 days after CRF. As expected, serum creatinine, cholesterol and triglycerides (mean +/- SEM) were higher in the CRF groups compared to the C groups (P<0.05). The RS group presented lower cholesterol (84 +/- 4 vs 126 +/- 13 mg%) and triglyceride (88 +/- 9 vs 132 +/- 19 mg%) levels compared to the RN group. Proteinuria and kidney weight did not differ between CRF groups. Glomerular area increased 78% in RS and 100% in RN compared to control rats. Glomerular sclerosis index tended to be lower in RS (27%) compared to RN (38%), tubulointerstitial damage was similar between CRF groups (RS = 1.91 +/- 0.2 and RN = 2.14 +/- 0.3), and mesangial fractional volume increased to the same extent in both CRF groups. The data suggest that a linoleic acid-enriched diet did not protect against the progression of CRF after 60 days.
authors.affiliation: Divisão de Patologia, Universidade Federal Fluminense, Niterói, 22240-070 Rio de Janeiro, Brazil.
authors.forename: S M P
authors.initials: SM
authors.lastname: Gregório
authors.forename: C C S
authors.initials: CC
authors.lastname: Lemos
authors.forename: M L
authors.initials: ML
authors.lastname: Caldas
authors.forename: R
authors.initials: R
authors.lastname: Bregman
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D019587:Dietary Supplements; D018450:Disease Progression; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000503:physiopathology*; D019787:Linoleic Acid / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D008297:Male; D011507:Proteinuria / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D004042:Dietary Fats, Unsaturated; D014280:Triglycerides; D002784:Cholesterol; D019787:Linoleic Acid; D003404:Creatinine