Effect of intraperitoneal administration of low-molecular-weight heparin on plasma tissue factor pathway inhibitor levels in CAPD patients.
We investigated the systemic effect of intraperitoneal low-molecular-weight heparin (LMWH) in continuous ambulatory peritoneal dialysis (CAPD) patients by measuring plasma total tissue factor pathway inhibitor (TFPI) levels, regarding the fact that the levels of plasma TFPI increases 2- to 4-fold after subcutaneous and intravenous administration of unfractioned heparin or LMWH. Eleven men and 6 women who had been on CAPD for 32 +/- 26 months and 15 healthy controls were included in the study. After administration of intraperitoneal enoksiparin in dialysate, plasma samples were obtained 4 h later. TFPI levels were significantly higher in CAPD patients (207.8 +/- 55 ng/ml) compared to the healthy subjects (72.5 +/- 29 ng/ml) (p < 0.0001). Both TFPI levels (225.9 +/- 47 vs. 207.8 +/- 55 ng/ml) (p < 0.54) and plasma factor Xa (anti-FXa assay) (0.097 +/- 0.14 vs. 0.093 +/- 0.16 U/ml) (p < 0.54) levels did not show any statistical difference before and after intraperitoneal administration of LMWH. By these findings we might suggest that intraperitoneal LMWH does not have any systemic effect.
Demirkan
Faith
F
Dokuz Eylul University School of Medicine, Department of Medicine, Division of Hematology/Oncology, Izmir, Turkey. faith.demirkan@deu.edu.tr
Akarsu
Mesut
M
Sifil
Aykut
A
Tutucu
Kutlay Naci
KN
D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D015951:Factor Xa / Q000378:metabolism; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007274:Injections, Intraperitoneal; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D015951:Factor Xa