title: Induction of DNA damage by oxidised amino acids and proteins.
abstract: Exposure of amino acids, peptides and proteins to radicals in the presence of O2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO*), peroxyl (ROO*) and carbon-centred (R) species. These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.
authors.affiliation: The Heart Research Institute, Sydney, NSW, Australia.
authors.forename: Catherine
authors.initials: C
authors.lastname: Luxford
authors.forename: Roger T
authors.initials: RT
authors.lastname: Dean
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Davies
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D004249:DNA Damage; D004587:Electrophoresis, Agar Gel; D006861:Hydrogen Peroxide / Q000378:metabolism; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D011506:Proteins; D006861:Hydrogen Peroxide