title: Effect of a bicarbonate-containing dentifrice on pH changes in a gel-stabilized plaque after exposure to sucrose.
abstract: Because many factors influence the acid-forming ability of dental plaque in the mouth, a model system was used in which reproducible Stephan curves could be generated after exposure of a gel-stabilized plaque to sucrose. Simulation of the use of a high-bicarbonate dentifrice at a time when plaque pH had fallen to about 4.5 caused a rapid return of the pH toward neutrality, whereas simulation of the use of a low-bicarbonate dentifrice had much less effect.
authors.affiliation: Faculty of Dentistry, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Dawes
mesh_terms: D000704:Analysis of Variance; D003773:Dental Plaque / Q000737:chemistry*; D003802:Dentifrices / Q000737:chemistry / Q000494:pharmacology*; D006861:Hydrogen Peroxide; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008954:Models, Biological; D012464:Saliva, Artificial; D012824:Silicic Acid; D012822:Silicon Dioxide; D017693:Sodium Bicarbonate / Q000494:pharmacology*; D012969:Sodium Fluoride; D018709:Statistics, Nonparametric; D013395:Sucrose / Q000494:pharmacology; D014100:Toothpastes
chemical_list: D003802:Dentifrices; D012464:Saliva, Artificial; D014100:Toothpastes; C546060:hydrated silica gel-based toothpaste; C546054:sodium bicarbonate-based toothpaste; D012824:Silicic Acid; D013395:Sucrose; D012822:Silicon Dioxide; D017693:Sodium Bicarbonate; D012969:Sodium Fluoride; D006861:Hydrogen Peroxide