[Is atherosclerosis an autoimmunological process?].
The theories formulated to explain atherogenesis evolved from simple vessel wall lipid accumulation assumption to endothelial dysfunction with adverse vascular wall remodelling hypothesis. The theory that has been accepted lately integrates the former hypotheses and allows for introducing the local immunological activation concept. This immunological activation is initiated by negatively charged and oxidatively modified lipids (e.g. oxPAPC) and their complexes with proteins (like beta 2-GP I). Antibodies and cellular response against chaperonins: HSP 60 and their analogues from bacterial pathogens such as HSP 65, GroEi etc.) as well as release of cytokines, adhesion molecules and inflammatory mediators (CD 40/CD 40-L, IL 15, IFN gamma, IL 1 beta, TNF alpha) also take part in the process. Another important element of atherogenesis is the pathological angiogenic response within the plaque connected with the expression of angiogenic growth factors (such as VEGF, bFGF and PDGF), metallo-proteinases and local hemostasis regulators. This complex activation of local inflammatory and immunological process initiates such phenomena as development of unstable plaque, vascular remodelling, vessel lumen constriction and ischemic, thromboembolic complications of atherosclerosis.
Partyka
Ł
Ł
Zakład Biochemii Klinicznej Collegium Medicum Uniwersytet Jagielloński, Kraków.
Hartwich
J
J
Kieć-Wilk
B
B
Polus
A
A
Wybrańska
I
I
Dembińska-Kieć
A
A
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity; D015815:Cell Adhesion Molecules / Q000276:immunology; D018833:Chaperonins / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology
D001323:Autoantibodies; D015815:Cell Adhesion Molecules; D016207:Cytokines; D018833:Chaperonins