[Biochemical mechanisms of genome-protective activity of pyridine carbonic acid new derivatives with cells damaged by tetrachloromethane].
The biochemical mechanisms of genomoprotective action of the new derivatives of pyridinecarbonic acids--PV-3, PV-4 and PV-6 in the conditions of tetrachloromethane chemical cell damage have been studied. This effect is related to their antioxidant influence on LPO processes in transcriptionally active and repressed chromatin fractions of rat liver cells and partial restoration of these fractions structure which has been destroyed during intoxication. PV-4 possesses the most genoprotective activity among the substances studied.
Hubs'kyĭ
Iu I
IuI
Institute of Pharmacology and Toxicology, AMS of Ukraine, Kyiv.
Levyts'kyĭ
Ie L
IeL
Horiushko
H H
HH
Marchenko
O M
OM
Prymak
R H
RH
Danylenko
V P
VP
Ovruts'tkyĭ
V M
VM
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D002255:Carbonic Acid / Q000737:chemistry / Q000494:pharmacology*; D016678:Genome; D008099:Liver / Q000187:drug effects*; D008297:Male; D011725:Pyridines / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D016587:Antimutagenic Agents; D011725:Pyridines; D002255:Carbonic Acid; D002251:Carbon Tetrachloride; C023666:pyridine