Pathophysiology of plaque instability: insights at the genomic level.
Atherosclerosis and plaque rupture represent complex "traits" of unknown cause that involve multiple genes and their variants. Novel genomic technologies provide us with the tools that will allow for the identification of groupings of genes that determine either susceptibility or resistance relative to the development of atherosclerosis and its thromboembolic complications. This information may, in turn, lead to a clearer understanding of the cause and risk for atherosclerosis. Diagnostic tools, as well as preventive and therapeutic strategies, will be derived from such heightened understanding of the disease process. With this chapter, we have presented the current state of knowledge of atherosclerosis genomics.
Lopes
Neuza
N
Division of Cardiology, Department of Medicine, Cardiovascular Center For Genomic Science, Duke University Medical Center, Durham, NC 27710, USA.
Vasudevan
Sanjay S
SS
Alvarez
Rene J
RJ
Binkley
Philip F
PF
Goldschmidt
Pascal J
PJ
D001161:Arteriosclerosis / Q000235:genetics* / Q000503:physiopathology*; D023281:Genomics; D006801:Humans; D011110:Polymorphism, Genetic; D012422:Rupture, Spontaneous / Q000235:genetics