Eight new HLA-A alleles associated with antigens in the A2 CREG.
This report describes eight novel HLA-A alleles. Seven of these new alleles contain substitutions previously reported in other HLA-A alleles, suggesting an origin resulting from a gene conversion mechanism. Of these seven, A*2431 contains a substitution previously associated with a larger polymorphic motif. A*0247 contains a substitution at a previously polymorphic position, but encodes an amino acid change previously unreported in any HLA-A, -B or -C alleles.
Gans
C P
CP
Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA.
Bradshaw
D M
DM
Jones
P F
PF
Mitton
W
W
Koester
R
R
Ng
J
J
Hartzman
R J
RJ
Hurley
Carolyn K
CK
D000483:Alleles; D001483:Base Sequence; D003429:Cross Reactions; D005091:Exons; D015234:HLA-A Antigens / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
D015234:HLA-A Antigens