title: Evaluation of the clonality of multilobar bronchioloalveolar carcinoma of the lung: case report.
abstract: A case of multilobar bronchioloalveolar carcinoma (BAC) is reported. To investigate the clonality of BAC, immunohistochemical staining as well as genetic analysis were performed. To investigate point mutations of the p53 gene, we used the polymerase chain reaction and fluorescence-based single strand conformation polymorphism analysis method. The BAC tissues of the right upper lobe, right lower lobe, and the other lobes were considered to be multiclonal. This case suggests that multilobar BAC might occur with multiclonality.
authors.affiliation: First Department of Internal Medicine, Kagawa Medical University, Kochi, Japan.
authors.forename: Nobuki
authors.initials: N
authors.lastname: Nanki
authors.forename: Jiro
authors.initials: J
authors.lastname: Fujita
authors.forename: Satoko
authors.initials: S
authors.lastname: Hojo
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.forename: Shuji
authors.initials: S
authors.lastname: Bandoh
authors.forename: Nobuya
authors.initials: N
authors.lastname: Ohara
authors.forename: Katsuya
authors.initials: K
authors.lastname: Miyatani
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Yamaji
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ohtsuki
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ishida
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000235:genetics* / Q000473:pathology; D000368:Aged; D016158:Genes, p53; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D009154:Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational