title: The endogenous granulocyte colony-stimulating factor response following autologous peripheral blood stem cell transplantation is impaired in patients with myeloma.
abstract: Granulocyte colony-stimulating factor (G-CSF) levels were studied in 23 patients (10 myeloma, 13 relapsed Hodgkin's disease, non-Hodgkin's lymphoma or germ cell tumours), post autologous peripheral blood stem cell transplantation (PBSCT). The two groups had similar previous chemotherapy and numbers of CD34+ cells transplanted. All patients received G-CSF by injection starting 8 d post transplantation. Twenty out of 23 patients showed raised endogenous levels of G-CSF before cytokine administration. Myeloma patients showed significantly lower levels of endogenous G-CSF than the other patients (0.767 versus 3.262 ng/ml, P < 0.05). Further rises in G-CSF levels were seen following the administration of exogenous G-CSF which then fell, despite ongoing administration of G-CSF, as neutrophil recovery occurred.
authors.affiliation: Department of Haematology, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK. curly.morris@bll.n-i.nhs.uk
authors.forename: Treen C M
authors.initials: TC
authors.lastname: Morris
authors.forename: Margaret K
authors.initials: MK
authors.lastname: Magill
authors.forename: Mary
authors.initials: M
authors.lastname: Drake
authors.forename: Susan
authors.initials: S
authors.lastname: Price
authors.forename: Lisa
authors.initials: L
authors.lastname: Ranaghan
authors.forename: Stephen
authors.initials: S
authors.lastname: Bridget
authors.forename: Anne E
authors.initials: AE
authors.lastname: Jordan
authors.forename: Alexandra E
authors.initials: AE
authors.lastname: Irvine
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood* / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000097:blood / Q000628:therapy; D006801:Humans; D007958:Leukocyte Count; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000628:therapy*; D009504:Neutrophils / Q000473:pathology; D013736:Testicular Neoplasms / Q000097:blood / Q000628:therapy
chemical_list: D016179:Granulocyte Colony-Stimulating Factor