title: Newer antidotal therapies.
abstract: Although the availability of an antidote for a toxic agent does not take away the primary responsibility of the clinician to manage the patient's clinical signs, the use of antidotes in appropriate situations can result in a more rapid recovery with potentially fewer long-term complications. Recent advances in pharmacology and molecular biology have resulted in the development of new and safer antidotal therapies for the management of toxicosis. The progress in immunotoxicotherapy over the last two decades continues and may ultimately lead to an era when the clinical toxicologist has a vast array of antibody fragments available for use with specific toxic agents. Development of specific pharmacologic antagonists for other agents should also enable the clinician to more reliably manage toxicoses. In spite of all these potential advances, the management of most toxicoses still relies on the application of sound veterinary medical principles.
authors.affiliation: Animal Poison Control Center, 1717 South Philo Road, Suite 36, Urbana, IL 61802, USA. gwalt@napcc.aspca.org
authors.forename: Sharon M
authors.initials: SM
authors.lastname: Gwaltney-Brant
authors.forename: Wilson K
authors.initials: WK
authors.lastname: Rumbeiha
mesh_terms: D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D000997:Antivenins / Q000627:therapeutic use; D003435:Crotalid Venoms; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D011041:Poisoning / Q000517:prevention & control / Q000662:veterinary*; D012909:Snake Bites / Q000517:prevention & control / Q000662:veterinary; D019155:Veterinary Drugs / Q000627:therapeutic use; D014730:Veterinary Medicine / Q000379:methods
chemical_list: D000931:Antidotes; D000997:Antivenins; D003435:Crotalid Venoms; D004791:Enzyme Inhibitors; D019155:Veterinary Drugs