title: Discovery and evaluation of N-(triazin-1,3,5-yl) phenylalanine derivatives as VLA-4 integrin antagonists.
abstract: SAR studies aimed at improving the rate of clearance of a series of VLA-4 integrin antagonists by the introduction of a 1,3,5-triazine as an amide isostere are described.
authors.affiliation: Celltech R&D Ltd, 216 Bath Road, Slough SL1 4EN, UK. john.porter@celltechgroup.com
authors.forename: John R
authors.initials: JR
authors.lastname: Porter
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Archibald
authors.forename: Julien A
authors.initials: JA
authors.lastname: Brown
authors.forename: Kirstie
authors.initials: K
authors.lastname: Childs
authors.forename: David
authors.initials: D
authors.lastname: Critchley
authors.forename: John C
authors.initials: JC
authors.lastname: Head
authors.forename: Brian
authors.initials: B
authors.lastname: Hutchinson
authors.forename: Ted A H
authors.initials: TA
authors.lastname: Parton
authors.forename: Martyn K
authors.initials: MK
authors.lastname: Robinson
authors.forename: Anthony
authors.initials: A
authors.lastname: Shock
authors.forename: Graham J
authors.initials: GJ
authors.lastname: Warrellow
authors.forename: Alex
authors.initials: A
authors.lastname: Zomaya
mesh_terms: D039041:Integrin alpha4beta1 / Q000037:antagonists & inhibitors*; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D039041:Integrin alpha4beta1; C468808:N-(triazin-1,3,5-yl) phenylalanine; D014227:Triazines; D010649:Phenylalanine