Activation of IL-1 signaling pathway in Schwann cells during diabetic neuropathy.
Our results show activation of the IL-1 signaling pathway in Schwann cells (SC), prior to and during early stages of diabetic neuropathy, thus suggesting its role in the initiation of SC-axonal miscommunication.
Skundric
Dusanka S
DS
Division of Neuroimmunology, Department of Neurology, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA. skundric@cmb.biosci.wayne.edu
Dai
Rujuan
R
James
Jascinth
J
Lisak
Robert P
RP
D000818:Animals; D020170:Caspase 1 / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000378:metabolism* / Q000473:pathology*; D007375:Interleukin-1 / Q000378:metabolism*; D053592:Interleukin-1 Receptor-Associated Kinases; D008856:Microscopy, Fluorescence; D018992:Myelin-Associated Glycoprotein; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats; D011913:Rats, Inbred BB; D011956:Receptors, Cell Surface / Q000378:metabolism; D012583:Schwann Cells / Q000378:metabolism* / Q000473:pathology; D012584:Sciatic Nerve; D015398:Signal Transduction
D007375:Interleukin-1; C104739:Mag protein, mouse; D018992:Myelin-Associated Glycoprotein; D011956:Receptors, Cell Surface; D011494:Protein Kinases; D053592:Interleukin-1 Receptor-Associated Kinases; D020170:Caspase 1