Acquired factor VIII inhibitors as a cause of primary post-partum haemorrhage.
Acquired haemophilia was diagnosed following detailed investigation of a post-partum haemorrhage unresponsive to standard management. Circulating factor VIII inhibitors and low factor VIII levels were detected and intravenous DDAVP treatment lead to a resolution of symptoms. This case highlights the importance of haematological investigations in persisting post-partum haemorrhage.
Howland
E J
EJ
Departments of Obstetrics and Gynaecology and Haematology, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UK.
Palmer
Julia
J
Lumley
Matthew
M
Keay
Stephen D
SD
D000328:Adult; D001323:Autoantibodies; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000627:therapeutic use; D005169:Factor VIII / Q000032:analysis / Q000276:immunology*; D005260:Female; D006467:Hemophilia A / Q000276:immunology; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D010314:Partial Thromboplastin Time; D006473:Postpartum Hemorrhage / Q000188:drug therapy / Q000276:immunology*; D014148:Tranexamic Acid / Q000627:therapeutic use
D001323:Autoantibodies; D006490:Hemostatics; D014148:Tranexamic Acid; D005169:Factor VIII; D003894:Deamino Arginine Vasopressin