title: Translocation of the HMGI-C ( HMGA2) gene in a benign mesenchymoma (chondrolipoangioma).
abstract: Mesenchymomas are neoplasms in which there are at least two types of differentiated cells of mesenchymal derivation other than fibrous tissue. Chondrolipoangioma is a rare type of mesenchymoma composed predominantly of cartilage and adipose tissue with vascular elements and myxoid tissue present in lesser proportions. Cytogenetic analysis was performed on a case of chondrolipoangioma and revealed a t(12;15) (q13;q26) as the sole chromosome abnormality in 40 metaphases analyzed. However, using fluorescence in situ hybridization (FISH) analysis, a complex rearrangement was found involving chromosomes 2, 12, and 15, with a cryptic rearrangement of the gene ( HMGI-C; HMGA2) coding for high-mobility group I protein. This finding suggests a role for the HMGI-C gene also in the pathogenesis of this uncommon benign tumor type, in addition to its well-established role in the pathogenesis of common benign tumors such as lipomas, uterine leiomyomas, pulmonary chondroid hamartomas, and endometrial polyps.
authors.affiliation: Department of Pathology, University Hospital St-Raphaël, Leuven Catholic University, Minderbroederstraat 12, 3000 Leuven, Belgium.
authors.forename: Jo
authors.initials: J
authors.lastname: Van Dorpe
authors.forename: Paola
authors.initials: P
authors.lastname: Dal Cin
authors.forename: Stanislawa
authors.initials: S
authors.lastname: Weremowicz
authors.forename: Fred
authors.initials: F
authors.lastname: Van Leuven
authors.forename: Ivo
authors.initials: I
authors.lastname: de Wever
authors.forename: Herman
authors.initials: H
authors.lastname: Van den Berghe
authors.forename: Christopher D M
authors.initials: CD
authors.lastname: Fletcher
authors.forename: Raf
authors.initials: R
authors.lastname: Sciot
mesh_terms: D000199:Actins / Q000032:analysis; D001706:Biopsy; D002881:Chromosomes, Human, Pair 12; D002884:Chromosomes, Human, Pair 15; D003893:Desmin / Q000032:analysis; D025743:HMGA2 Protein / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008637:Mesenchymoma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000235:genetics* / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis; D014178:Translocation, Genetic
chemical_list: D000199:Actins; D003893:Desmin; D025743:HMGA2 Protein; D009418:S100 Proteins