title: Postictal mixed transcortical aphasia.
abstract: Postictal aphasia has been described in left temporal lobe seizures. It may be of fluent, non-fluent or global type. We present here a patient who displayed signs of mixed transcortical aphasia (MTCA). The patient was a 67 year old man who underwent excision of a left frontal parasagittal meningioma in 1987. Since then he has been treated with phenytoin for generalized tonic-clonic seizures (GTCS). He was admitted in status epilepticus. On awakening, the patient was non-fluent with palilalia and echolalia. His repetition was relatively preserved but all the other language functions were impaired. This picture faded away within a few hours. Brain CT, performed during this postictal state, was normal except for signs related to frontal craniotomy. SPECT, which was performed after language functions returned to normal, displayed left frontal, cingular and insular hypoperfusion. The postictal language dysfunction of the patient corresponded to MTCA. Although our case has frontal, he had no other structural lesion that could explain either diffuse ischemia of the left hemisphere or watershed areas secondary to the generalized seizures. The uniqueness of this case is the combination of postictal MTCA with good prognosis.
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: A E
authors.initials: AE
authors.lastname: Yankovsky
authors.forename: T A
authors.initials: TA
authors.lastname: Treves
mesh_terms: D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use; D001037:Aphasia / Q000209:etiology* / Q000503:physiopathology; D001039:Aphasia, Broca / Q000209:etiology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004830:Epilepsy, Tonic-Clonic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005625:Frontal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000627:therapeutic use; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin