title: Preparation, characterization, molecular modeling and in vitro activity of paclitaxel-cyclodextrin complexes.
abstract: Paclitaxel (PTX) was complexed with beta-cyclodextrin (1), 2,6-dimethyl-beta-cyclodextrin (2) and 2,3,6-trimethyl-beta-cyclodextrin (3). PTX-CYD complexes were characterized both at the solid and liquid states. Experimental findings are in agreement with molecular modeling analysis, which showed different PTX-CYD interaction as a function of macrocyle methylation. The complexation of PTX within the CYD cavity preserved its antitumoral activity.
authors.affiliation: Department of Pharmacobiological Sciences, University Magna Graecia of Catanzaro, Complesso Ninì Barbieri, I-88021 Roccelletta di Borgia (CZ), Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Alcaro
authors.forename: Cinzia Anna
authors.initials: CA
authors.lastname: Ventura
authors.forename: Donatella
authors.initials: D
authors.lastname: Paolino
authors.forename: Danilo
authors.initials: D
authors.lastname: Battaglia
authors.forename: Francesco
authors.initials: F
authors.lastname: Ortuso
authors.forename: Luigi
authors.initials: L
authors.lastname: Cattel
authors.forename: Giovanni
authors.initials: G
authors.lastname: Puglisi
authors.forename: Massimo
authors.initials: M
authors.lastname: Fresta
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002942:Circular Dichroism; D003505:Cyclodextrins / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003505:Cyclodextrins; D017239:Paclitaxel