[Proliferation and morphological differentiation of neurblastoma cells in cultured under the effect of avermectins].
The effect of natural avermectin complex (Aversectin C) and Abamectin on the processes of proliferation and morphological differentiation of the neural cells was studied using N1E-115 murine neuroblastoma cells (clone C-1300) as a model. Aversectin C in concentrations 10(-7)-10(-8) was shown to induce morphological differentiation of cultured nervous cells. Treatment with Abamectin resulted in the changes of proliferation pattern of the cells. Morphological differentiation of the cultured nervous cells treated with Aversectin C was associated with electrophysiological one.
Miakisheva
S N
SN
Scientific Biological Center Pharmbiomed, Laboratory of the Nervous Cell Biophysics, RAS Institute of Cell Biophysics, Pushino, Moscow District.
Kostenko
M A
MA
Driniaev
V A
VA
Mosin
V A
VA
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051379:Mice; D009447:Neuroblastoma / Q000473:pathology*; D014407:Tumor Cells, Cultured
C048324:abamectin; D007559:Ivermectin; C019264:avermectin