HLA-B35 association with nephritis in Henoch-Schönlein purpura.
OBJECTIVE
To investigate the implications of the HLA-B locus in the susceptibility to Henoch-Schönlein purpura (HSP) and determine if there are associations with renal and gastrointestinal (GI) manifestations of the disease.


METHODS
A retrospective study was performed on an unselected population of patients with HSP from Northwest Spain. Forty-eight Caucasian patients (24 women), 11 of them older than 20 years, were studied. Patients and ethnically matched controls were HLA-B genotyped from DNA using molecular based methods.


RESULTS
When patients with HSP were compared with matched controls, no differences in HLA-B frequencies were observed. No HLA-B associations with GI manifestations were observed. In contrast, an increased frequency of HLA-B35 was observed in patients with renal manifestations (10 of 31) compared to those without (0 of 17). No significant distortions in frequency were seen for any other HLA-B alleles with HSP subgroups.


CONCLUSIONS
Our results support a role of HLA-B35 in the susceptibility for nephritis in unselected patients with HSP.
Amoli
Mahsa M
MM
ARC Epidemiology Unit, Manchester University Medical School, United Kingdom.
Thomson
Wendy
W
Hajeer
Ali H
AH
Calviño
Maria C
MC
Garcia-Porrua
Carlos
C
Ollier
William E R
WE
Gonzalez-Gay
Miguel A
MA
D000328:Adult; D002648:Child; D005260:Female; D005838:Genotype; D015797:HLA-B35 Antigen / Q000235:genetics*; D006801:Humans; D011695:IgA Vasculitis / Q000235:genetics* / Q000276:immunology; D015810:Linkage Disequilibrium; D008297:Male; D009393:Nephritis / Q000235:genetics* / Q000276:immunology; D010641:Phenotype; D012189:Retrospective Studies
D015797:HLA-B35 Antigen