title: Decreased short-term renal graft survival in Maghrebian recipients.
abstract: The influence of race on renal allograft survival is disputed. We studied 16 cadaveric renal transplants in 14 Maghrebian patients, each matched with two controls of local origin. Patient survival at 12 months was 93% in the Maghreb group and 97% in the control group (NS). Graft survivals at 3 months for these two groups were 73% and 97%, respectively (P<0.01). At 6 months, graft survival in the control group remained unchanged at 97%, whereas in the case group it declined further to 59% (P<0.01). Overall graft failure in the Maghreb group amounted to 44% (seven of 16 transplants). In each case, failure was due to biopsy-proven acute rejection. Overall graft failure amongst the controls was only 6% (two of 32 transplants) (P=0.004) (only one case of acute rejection, or 3%) (P=0.01). This study provides evidence for significantly lower short-term renal graft survival in Maghrebian recipients of a Caucasian graft. Acute rejection seems to play a major causative role in graft loss in this group.
authors.affiliation: Department of Nephrology-Hypertension, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium.
authors.forename: Willem E
authors.initials: WE
authors.lastname: Boer
authors.forename: Gerda
authors.initials: G
authors.lastname: Van Beeumen
authors.forename: Monique M
authors.initials: MM
authors.lastname: Elseviers
authors.forename: Dirk K
authors.initials: DK
authors.lastname: Ysebaert
authors.forename: Thierry
authors.initials: T
authors.lastname: Chapelle
authors.forename: Marie-Madeleine
authors.initials: MM
authors.lastname: Couttenye
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Bosmans
authors.forename: Marc E
authors.initials: ME
authors.lastname: De Broe
authors.forename: Gert A
authors.initials: GA
authors.lastname: Verpooten
mesh_terms: D000328:Adult; D000352:Africa, Northern; D001530:Belgium; D044383:Black People; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival / Q000502:physiology*; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology*; D008297:Male; D044469:Racial Groups; D016019:Survival Analysis; D013997:Time Factors; D014019:Tissue Donors; D017211:Treatment Failure