[Pleiotropic effects of statins].
The advent of statin therapy has revolutionized the ability of the clinician to manage patients at risk for the development of an ischemic event due to dyslipidemia. Large-scale clinical trials involving thousands of patients in both primary and secondary prevention have clearly demonstrated that statin therapy will reduce cardiovascular mortality across a broad spectrum of patient subgroups. However, the precise mechanism underlying the benefit of statin therapy has been controversial due to the multiplicity of potential benefits that statins have demonstrated in addition to pure lipid lowering. Recent experimental evidence supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque vulnerability).
Mori
Seijiro
S
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University.
Saito
Yasushi
Y
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D009000:Monocytes / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects
D000924:Anticholesteremic Agents; D007166:Immunosuppressive Agents