[Activity of glutathione reductase and glutathione-S-transferase in rabbit brain tissue in the long-term post-traumatic period].
The glutathione-reductase and glutathione-S-transferase activities in the cortex and brain stem tissues of rabbits with post-traumatic epileptic reality (1 year after the light brain injury) was defined. An increase of glutathione-reductase activity in the cortex microsomal and stem mitochondrial fractions, and increase of glutathione-S-transferase activity in cortex and stem mitochondrial fractions was obtained. The conclusion is made that the activation of the anti-oxidant glutathione fermentative system is a long-term metabolic CNS adaptation in the case while mitochondrial oxidation and oxidative phosphorilation are disturbed.
Cherchenko
A P
AP
Institute of Neurosurgery, AMS of Ukraine, Kyiv.
Chelnakova
I S
IS
D000222:Adaptation, Physiological; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000503:physiopathology; D005980:Glutathione Reductase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D014947:Wounds and Injuries / Q000201:enzymology* / Q000503:physiopathology
D005980:Glutathione Reductase; D005982:Glutathione Transferase