A phase II study of low-dose megestrol acetate using twice-daily dosing for anorexia in nonhormonally dependent cancer.
Anorexia is a common problem in advanced cancer. Low-dose megestrol acetate, a semi-synthetic progesterone, given twice daily, is an effective appetite stimulant in advanced cancer patients. There was an excellent correlation between patient satisfaction and the primary response criteria (appetite improvement). Given cost, side-effect profile, ease of administration, and efficacy, 80 mg twice daily after meals is an appropriate starting dose of megestrol acetate for anorexia in advanced cancer. If this is not effective, considerable dose escalation is possible.
Nelson
Kristine A
KA
Taussig Cancer Center, Cleveland Clinic Foundation, Ohio, USA.
Walsh
Declan
D
Hussein
Mohamad
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000855:Anorexia / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D019167:Appetite Stimulants / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D019290:Megestrol Acetate / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D017060:Patient Satisfaction; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
D019167:Appetite Stimulants; D019290:Megestrol Acetate