title: Effect of intraperitoneal administration of low-molecular-weight heparin on plasma tissue factor pathway inhibitor levels in CAPD patients.
abstract: We investigated the systemic effect of intraperitoneal low-molecular-weight heparin (LMWH) in continuous ambulatory peritoneal dialysis (CAPD) patients by measuring plasma total tissue factor pathway inhibitor (TFPI) levels, regarding the fact that the levels of plasma TFPI increases 2- to 4-fold after subcutaneous and intravenous administration of unfractioned heparin or LMWH. Eleven men and 6 women who had been on CAPD for 32 +/- 26 months and 15 healthy controls were included in the study. After administration of intraperitoneal enoksiparin in dialysate, plasma samples were obtained 4 h later. TFPI levels were significantly higher in CAPD patients (207.8 +/- 55 ng/ml) compared to the healthy subjects (72.5 +/- 29 ng/ml) (p < 0.0001). Both TFPI levels (225.9 +/- 47 vs. 207.8 +/- 55 ng/ml) (p < 0.54) and plasma factor Xa (anti-FXa assay) (0.097 +/- 0.14 vs. 0.093 +/- 0.16 U/ml) (p < 0.54) levels did not show any statistical difference before and after intraperitoneal administration of LMWH. By these findings we might suggest that intraperitoneal LMWH does not have any systemic effect.
authors.affiliation: Dokuz Eylul University School of Medicine, Department of Medicine, Division of Hematology/Oncology, Izmir, Turkey. faith.demirkan@deu.edu.tr
authors.forename: Faith
authors.initials: F
authors.lastname: Demirkan
authors.forename: Mesut
authors.initials: M
authors.lastname: Akarsu
authors.forename: Aykut
authors.initials: A
authors.lastname: Sifil
authors.forename: Kutlay Naci
authors.initials: KN
authors.lastname: Tutucu
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D015951:Factor Xa / Q000378:metabolism; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007274:Injections, Intraperitoneal; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D015951:Factor Xa