Interstitial cells of Cajal and purinergic signalling.
Interstitial cells of Cajal (ICC) in the guinea pig intestine, identified by the tyrosine kinase receptor, c-Kit, have been shown with immunohistochemistry to express nucleotide P2X2 and P2X5 receptors. P2X5 receptors have also been demonstrated on interstitial cells in the mouse ileum. It is speculated that release of ATP from enteric nerves, enteric glial cells or from contracting smooth muscle may provide a feedback mechanism for pacemaker activity in the intestine.
Burnstock
G
G
Autonomic Neuroscience Institute, Royal Free and University College Medical School, London, UK. g.burnstock@ucl.ac.uk
Lavin
S
S
D000818:Animals; D006168:Guinea Pigs; D007082:Ileum / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D051379:Mice; D009197:Myenteric Plexus / Q000378:metabolism; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D058476:Receptors, Purinergic P2X2; D058485:Receptors, Purinergic P2X5; D015398:Signal Transduction
C546402:P2rx2 protein, mouse; C546466:P2rx5 protein, mouse; D018048:Receptors, Purinergic P2; D058476:Receptors, Purinergic P2X2; D058485:Receptors, Purinergic P2X5; D019009:Proto-Oncogene Proteins c-kit; D020794:Receptor Protein-Tyrosine Kinases