title: Cyclooxygenase-2 inhibitory 1,4-naphthoquinones from Impatiens balsamina L.
abstract: Significant selective cyclooxygenase-2 (COX-2) inhibitory activities were observed for two new 1,4-naphthoquinone sodium salts, sodium 3-hydroxide-2[[sodium 3-hydroxide-1,4-dioxo(2-naphthyl)]ethyl]naphthalene-1,4-dione (impatienolate) (1) and sodium 2-hydroxide-3-(2-hydroxyethyl)naphthalene-1,4-dione (balsaminolate) (2), which were isolated from the corolla of Impatiens balsamina L. (Balsaminaceae). Their structures were elucidated by spectral techniques. Our results offer evidence supporting the use of I. balsamina L. to treat articular rheumatism, pain, and swelling.
authors.affiliation: Mukogawa Women's University School of Pharmaceutical Sciences, Nishinomiya, Japan.
authors.forename: Hisae
authors.initials: H
authors.lastname: Oku
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ishiguro
mesh_terms: D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D029069:Impatiens / Q000737:chemistry*; D007527:Isoenzymes / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D009285:Naphthoquinones; C468312:sodium 2-hydroxide-3-(2-hydroxyethyl)naphthalene-1,4-dione; C468311:sodium-3-hydroxide-2((sodium 3-hydroxide-1,4-dioxo(2-naphthyl))ethyl)naphthalene-1,4-dione (impatienolate); D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases