title: 14'-Hydroxymytoxin B and 16-hydroxyroridin E, two new cytotoxic trichothecenes from Myrothecium roridum.
abstract: Two new trichothecenes, 14'-hydroxymytoxin B (1) and 16-hydroxyroridin E (3), were isolated from a fermentation extract of Myrothecium roridum. The structures of 1 and 3 were determined by spectral data interpretation. Both compounds showed potent cytotoxic activity against primary soft-tissue sarcoma cells.
authors.affiliation: Albany Molecular Research Inc., Bothell Research Center, 18804 North Creek Parkway, Bothell, Washington 98011-8012, USA. khisal.alvi@albmolecular.com
authors.forename: Khisal A
authors.initials: KA
authors.lastname: Alvi
authors.forename: John
authors.initials: J
authors.lastname: Rabenstein
authors.forename: Jon
authors.initials: J
authors.lastname: Woodard
authors.forename: Dwight D
authors.initials: DD
authors.lastname: Baker
authors.forename: Jennifer D
authors.initials: JD
authors.lastname: Bergthold
authors.forename: John
authors.initials: J
authors.lastname: Lynch
authors.forename: Kuo L
authors.initials: KL
authors.lastname: Lieu
authors.forename: Irwin A
authors.initials: IA
authors.lastname: Braude
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001900:Boston; D002478:Cells, Cultured / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012509:Sarcoma; D014255:Trichothecenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: C460126:14'-hydroxymytoxin B; C460127:16-hydroxyroridin E; D000970:Antineoplastic Agents; D014255:Trichothecenes