title: Coexistence of chronic myeloid leukemia and hairy cell leukemia of common clonal origin.
abstract: The history of a forty year old patient is presented who was admitted with a clinical picture of chronic myeloid leukemia (CML). Laboratory findings, bone marrow morphology and molecular investigations supported this diagnosis, including b3/a2 as well as b2/a2 chimeric mRNA expression in support of a Philadelphia chromosome positive chronic myeloproliferation. In a fraction of the bone marrow content, however, an infiltrate different from that of CML could be seen. In addition, the morphology, cytochemistry, immunophenotyping and molecular analysis indicated that the coexisting neoplasia is hairy cell leukemia (HCL). Cell lineage specific interphase cytogenetic analysis proved a clonal relationship between the two neoplasias in a way that the HCL arose from one of the B-cells which, based on two cytogenetic markers, belonged to the original CML clone.
authors.affiliation: Department of Pathology, Medical Faculty, University of Pécs, Pécs, Hungary. pajor@pathology.pote.hu
authors.forename: László
authors.initials: L
authors.lastname: Pajor
authors.forename: László
authors.initials: L
authors.lastname: Kereskai
authors.forename: Péter
authors.initials: P
authors.lastname: Tamáska
authors.forename: János A
authors.initials: JA
authors.lastname: Vass
authors.forename: Gáspár
authors.initials: G
authors.lastname: Radványi
mesh_terms: D000328:Adult; D019070:Cell Lineage; D002999:Clone Cells / Q000378:metabolism / Q000473:pathology*; D005434:Flow Cytometry; D015972:Gene Expression Regulation, Neoplastic; D016313:Genes, abl / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D007943:Leukemia, Hairy Cell / Q000235:genetics / Q000473:pathology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000473:pathology*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D012333:RNA, Messenger