Identification of inter-species transmission of prion strains.
The concern of the potential transmission of animal spongiform encephalopathies to humans, which arose as soon as the interspecies transmission of these diseases was recognized, has been reinforced with the emergence of bovine spongiform encephalopathy (BSE) in cattle. Recent experimental findings suggest that the infectious agent causing BSE in cattle can lead to the occurrence of a new form of Creutzfeldt-Jakob disease in humans. These findings help us understand how the transmission to humans of an animal disease may be recognized. This can involve an indirect approach through the analysis of neurodegeneration, either in the disease host, or more specifically, in genetically well-defined experimental hosts to which the disease can be transmitted. Recent experimental studies have also shown that the different molecular features of the abnormal form of the prion protein, which accumulates in the infected tissues, can provide important clues to the relationships between different spongiform encephalopathies. However, a better understanding of the molecular features associated with the specific pathogenic behavior of different strains is required. Complex relationships between the infectious agents involved in spongiform encephalopathies and the disease host can make the recognition of a link between animal prion strains and the human disease difficult to establish.
Baron
Thierry
T
Unité Virologie ATNC, Agence Française de Sécurité Sanitaire des Aliments, Lyon, France.
D000818:Animals; D002417:Cattle; D007562:Creutzfeldt-Jakob Syndrome / Q000635:transmission; D016643:Encephalopathy, Bovine Spongiform / Q000635:transmission; D006801:Humans; D017096:Prion Diseases / Q000635:transmission*; D011328:Prions / Q000737:chemistry; D012608:Scrapie / Q000635:transmission; D015047:Zoonoses / Q000635:transmission*
D011328:Prions