A case of neurotoxicity following 5-fluorouracil-based chemotherapy.
5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent. However, its neurotoxicity is rare and not well recognized. We report a case of 5-FU neurotoxicity with organic brain syndrome and progression to multifocal leukoencephalopathy in a 44-year-old male patient having malignant gastrointestinal stromal tumor. 5-FU-induced neurotoxicity should, therefore, be considered as an important differential diagnosis in cancer patients with neurological abnormality and history of chemotherapy.
Ki
Seung Seog
SS
Department of Internal Medicine, Korea Cancer Center Hospital, 215-4 Gongneung Dong, Nowon Ku, 139-240, Seoul, Korea.
Jeong
Jin Mo
JM
Kim
Seong Ho
SH
Jeong
Sook Hyang
SH
Lee
Jin Hyuk
JH
Han
Chul Ju
CJ
Kim
You Cheol
YC
Lee
Jhin Oh
JO
Hong
Young Joon
YJ
D000328:Adult; D001921:Brain / Q000473:pathology*; D004569:Electroencephalography; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000209:etiology*
D005472:Fluorouracil