title: Differences in EEG harmonic driving responses to photic stimulation between normal aging and Alzheimer's disease.
abstract: In order to investigate whether Alzheimer's disease (AD) is the end result of aging of the brain or the result of some other mechanism, we analyzed EEGs showing the absolute power of harmonic responses to photic stimulation (PS) in younger subjects, non-demented elderly subjects and AD patients. At rest, the AD patients generally showed less absolute power than the younger and elderly subjects, with significant differences found at 10 Hz and 20 Hz. Analysis of EEGs recorded during PS indicated that the elderly subjects generally demonstrated more absolute power than the younger subjects and AD patients. These findings suggest a failure of stimulation-related brain activation in AD patients, and provide further evidence that normal aging and AD employ different mechanisms for functional organization during PS.
authors.affiliation: Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. mitsuru@zc4.so-net.ne.jp
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Wada
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Koshino
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods*; D005074:Evoked Potentials, Visual; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic