Short-term regulation of insulin gene transcription.
Short-term regulation of insulin gene transcription is still a matter of debate. However, an increasing body of evidence shows that insulin gene transcription is affected by signals, such as incretins, glucose metabolites, intracellular Ca2+, and by insulin secreted from pancreatic beta-cells, all supporting the concept of an immediate response resulting in insulin gene transcription following food-uptake. The present review aims to summarize the current view on the mechanisms underlying the up-regulation of insulin gene transcription in response to glucose, the major nutrient factor in insulin secretion and biosynthesis.
Leibiger
Barbara
B
The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, S-17176 Stockholm, Sweden. barbara.leibiger@molmed.ki.se
Moede
T
T
Uhles
S
S
Berggren
P O
PO
Leibiger
I B
IB
D000818:Animals; D015703:Antigens, CD; D005786:Gene Expression Regulation; D017781:Genes, Immediate-Early; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000235:genetics* / Q000378:metabolism; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011401:Promoter Regions, Genetic; D011972:Receptor, Insulin / Q000378:metabolism; D038762:Ribosomal Protein S6 Kinases, 70-kDa / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic
D015703:Antigens, CD; D007328:Insulin; D019869:Phosphatidylinositol 3-Kinases; C435941:INSR protein, human; D011972:Receptor, Insulin; D038762:Ribosomal Protein S6 Kinases, 70-kDa; D005947:Glucose