Enhanced tumor development in mice lacking a functional type I interferon receptor.
The aim of this study was to investigate the contribution of endogenous - that is, without the addition of any interferon (IFN) inducer - type I IFN production in the defense against tumor development. To this purpose, the IFN-alpha receptor (IFNAR) knockout (KO)-induced mutation, resulting in the complete absence of IFN-alpha/beta activity, was introduced into a C3H genetic background by 10 backcross generations, followed by brother-sister matings for at least four generations. The resulting mice were inoculated either with syngeneic C3H melanoma K1735 cells, with allogeneic 3LL carcinoma cells, or with allogeneic B16F10 melanoma cells. With all three tumor cell lines, tumor development and ensuing mortality were enhanced in the IFNAR KO animals. This indicates that endogenous IFN-alpha/beta production is a mediator of natural immunity to tumor development.
Picaud
Sandrine
S
Institut Curie, Centre Universitaire, Orsay, France.
Bardot
Boris
B
De Maeyer
Edward
E
Seif
Isabelle
I
D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000473:pathology; D002455:Cell Division; D005260:Female; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D007700:Kinetics; D008297:Male; D008546:Melanoma, Experimental / Q000473:pathology; D008565:Membrane Proteins; D051379:Mice; D008809:Mice, Inbred C3H; D018345:Mice, Knockout; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology*; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000235:genetics / Q000502:physiology*; D015996:Survival Rate; D014407:Tumor Cells, Cultured
D008565:Membrane Proteins; D017471:Receptors, Interferon; D053633:Receptor, Interferon alpha-beta