title: Synthesis of novel furo, thieno, and benzazetoazepines and evaluation of their cytotoxicity.
abstract: We report the regio- and stereoselective synthesis of a novel cis-C(3)N-C(4)X-C(6)N series (X=O, S, and C(2)) from cyclic ketones. The cytotoxic activity of the new compounds was studied in five cell lines; the observed activities were in accordance with the concept of bioisosteric replacement.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510 Coyoacán, México, D.F., Mexico. robmar@servidor.unam.mx
authors.forename: L Roberto
authors.initials: LR
authors.lastname: Martínez
authors.forename: Jose Gustavo
authors.initials: JG
authors.lastname: Avila Zarraga
authors.forename: Ma Esther
authors.initials: ME
authors.lastname: Duran
authors.forename: Ma Teresa
authors.initials: MT
authors.lastname: Ramírez Apam
authors.forename: Roberto
authors.initials: R
authors.lastname: Cañas
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D001381:Azepines