Electrochemical and peroxidase oxidation study of N'-hydroxyguanidine derivatives as NO donors.
The electrochemical properties of a series of N-substituted-N'-hydroxyguanidines were studied. Two oxidation potentials of each compound were obtained by cyclic voltammetry. The E(ox1) values were from 0.51 to 0.62V, while the E(ox2) values were from 1.14 to 1.81V in acetonitrile solution. Next, their enzymatic controlled NO release abilities were evaluated. All N'-hydroxyguanidines exhibited efficient NO release abilities under the oxidation by horseradish peroxidase in the presence of H(2)O(2).
Cai
Tingwei
T
Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Xian
Ming
M
Wang
Peng George
PG
D001120:Arginine / Q000737:chemistry; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods; D005609:Free Radicals / Q000737:chemistry; D006146:Guanidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D006735:Horseradish Peroxidase / Q000737:chemistry* / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000737:chemistry; D006898:Hydroxylamines; D007501:Iron / Q000737:chemistry; D009249:NADP / Q000737:chemistry; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry* / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D009573:Nitrites / Q000737:chemistry; D010084:Oxidation-Reduction
D005609:Free Radicals; D006146:Guanidines; D006898:Hydroxylamines; D020030:Nitric Oxide Donors; D009573:Nitrites; C066317:ferryl iron; D009569:Nitric Oxide; D009249:NADP; C029604:hydroxyguanidine; D003577:Cytochrome P-450 Enzyme System; D001120:Arginine; D006861:Hydrogen Peroxide; D007501:Iron; D006735:Horseradish Peroxidase; D019001:Nitric Oxide Synthase