Synthesis, crystal structure, antitumor activity and DNA-binding study on the Mn(II) complex of 2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline.
The complex [Mn(L)(NO(3))(2)(H(2)O)(2)] (1) (L=2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline) was synthesized and characterized by elemental analysis, IR and UV. The crystal and molecular structure of 1 was determined by single-crystal X-ray diffraction; crystal data: light yellow, monoclinic, space group P2(1)/n, Z=4, a=7.432(2) A, b=9.582(3) A, c=23.445(7) A, beta=90.519(5) degrees. The Mn atom in 1 is hexa-coordinated in a distorted octahedral arrangement by two N atoms of the ligand L and four O atoms of two water molecules and two nitrate anions. Biological tests in vitro showed that 1 has significant antitumor activity against HL-60, KB, Hela and BGC-823 cells. The interaction of 1 with calf thymus DNA was investigated by absorption titration, thermal denaturation and viscosity measurements. The results suggest that 1 binds with DNA by intercalating via the ligand L.
Xu
Zhi Dong
ZD
National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, PR China.
Liu
He
H
Xiao
Su Long
SL
Yang
Ming
M
Bu
Xian He
XH
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002417:Cattle; D003460:Crystallization; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008345:Manganese / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013053:Spectrophotometry; D014407:Tumor Cells, Cultured; D014783:Viscosity
D000970:Antineoplastic Agents; C460339:Mn(II)2H-5-hydroxy-1,2,5-oxadiazo(3,4-f)1,10-phenanthroline; D009942:Organometallic Compounds; D008345:Manganese; D004247:DNA