Proteomic tools for biomedicine.
Proteomic tools measure gene expression, protein activity and interactions of biological events at the protein level. Proteins are the major catalysts of biological functions and contain several dimensions of information that collectively indicate the actual rather than the potential functional state as indicated by mRNA analysis. Measurements can be made in terms of protein quantity, location, and time-point. For the future we see a further integration of existing and new technologies for proteomics from a wide range of areas of biochemistry, chemistry, physics, computing science and molecular biology. This will further advance our knowledge of how biological systems are built up and what mechanisms control these systems. However, the potential of proteomics to comprehensively answer all biological questions is limited as only protein activity is measured. A unification of genomics, proteomics, and other technologies is needed if we are to start to understand the complexity of biological function in the context of disease and health.
Wasinger
Valerie C
VC
Mass Spectrometry and Protein Analysis Laboratory, Garvan Institute of Medical Research, 384 Victoria Street, Sydney, NSW 2010, Australia. v.wasinger@garvan.org.au
Corthals
Garry L
GL
D020543:Proteome
D020543:Proteome