title: [Adaptive mechanisms of bone tissue and regulatory-metabolic profile of the body].
abstract: The interrelationship of mechanisms of osseous tissue adaptation to the changes of mechanical loads and regulatory-metabolic influences is discussed on the basis of authors' findings and literature analysis. It is proposed to use the following concepts, which reflect the essence of functioning of different groups of mechanisms at various hierarchical levels of adaptation processes: organic matrix restructuring, osteocytic restructuring of minerals, osteocytic remodelling, osteoclastic-osteoblastic remodelling and reparative osteogenesis. The peculiarities of functioning of these mechanisms depend upon regulatory-metabolic changes which should be defined as organism regulatory-metabolic profile.
authors.affiliation: Isotope Research Laboratory, Russian R.R. Vreden Scientific Research Institute of Traumatology and Orthopedics, St. Petersburg.
authors.forename: A S
authors.initials: AS
authors.lastname: Avrunin
authors.forename: N V
authors.initials: NV
authors.lastname: Kornilov
authors.forename: I D
authors.initials: ID
authors.lastname: Ioffe
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism