title: International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: analyzing target autoantigens of humoral immunity in nonobese diabetic mice.
abstract: The aim of this workshop was to identify autoantibody assays that could provide useful markers of autoimmunity in the NOD mouse model for type 1 diabetes. It was demonstrated that insulin autoantibodies measured by sensitive radiobinding assay are a marker of autoimmunity in NOD mice and draw into question the true nature of GADA and IA-2A in this animal model.
authors.affiliation: Department of Medicine, Istituto Scientifico San Raffaele, Milan, Italy. bonifacio.ezio@hsr.it
authors.forename: Ezio
authors.initials: E
authors.lastname: Bonifacio
authors.forename: Mark
authors.initials: M
authors.lastname: Atkinson
authors.forename: George
authors.initials: G
authors.lastname: Eisenbarth
authors.forename: David
authors.initials: D
authors.lastname: Serreze
authors.forename: Thomas W H
authors.initials: TW
authors.lastname: Kay
authors.forename: Edwin
authors.initials: E
authors.lastname: Lee-Chan
authors.forename: Bhagirath
authors.initials: B
authors.lastname: Singh
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007328:Insulin / Q000276:immunology; D051379:Mice; D016688:Mice, Inbred NOD
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007328:Insulin; D005968:Glutamate Decarboxylase