Monosomy 15 in chronic myelomonocytic leukemia. description of a case and review of the literature.
We report a 89-year-old female diagnosed with chronic myelomonocytic leukemia (CMMoL) presenting with a monosomy 15. To our knowledge, this is the second reported case of CMMoL with monosomy 15. On the other hand, monosomy 15 in complex karyotypes is a frequent chromosome aberration in myelodysplastic syndromes, particularly in refractory anemia with excess of blasts.
Zamora
Lourdes
L
Laboratori de Citogenètica i Biologia Molecular, Departament de Patologia, Hospital del Mar, Pg Marítim, 25-29, 08003, Barcelona, Spain. e0037@imas.imim.es
Espinet
Blanca
B
Salido
Marta
M
Florensa
Lourdes
L
Woessner
Soledad
S
Pedro
Carmen
C
Serrtano
Sergi
S
Solé
Francesc
F
D000368:Aged; D000369:Aged, 80 and over; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics*; D009006:Monosomy / Q000235:genetics*