[The role of M-cholinoreceptor subtypes in heart rhythm disturbances of various etiology].
The experiments on rats showed different activities of pilocarpine, arecoline, and DDVF in tests for the onset of bradycardia and hypersalivation. A comparative study of the activity of selective M-cholinoblockers in preventing the arrhythmias induced by phosphacol and potassium cyanide showed that the activity of M1-antagonist pirenzepine is higher as compared to that of the M2-antagonist AF-DX-116; at the same time both drugs showed equal activity with respect to arrhythmias induced by aconitine, calcium chloride, and carbachol. It is suggested that the arrhythmias of various etiology involve different subtypes of M-cholinoreceptors.
Kosmachev
A B
AB
Institute of Toxicology, Ministry of Public Health of the Russian Federation, ul. Bekhtereva 1, St. Petersburg, 193019 Russia.
Fil'ko
O A
OA
Petrov
V V
VV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D051381:Rats; D043643:Receptor, Muscarinic M1; D043585:Receptor, Muscarinic M2; D011976:Receptors, Muscarinic / Q000502:physiology*
D000889:Anti-Arrhythmia Agents; D018727:Muscarinic Antagonists; D043643:Receptor, Muscarinic M1; D043585:Receptor, Muscarinic M2; D011976:Receptors, Muscarinic