title: Health-related quality of life associated with irritable bowel syndrome: comparison with other chronic diseases.
abstract: BACKGROUND
  Despite the rapidly growing body of literature on health-related quality of life (HRQoL). placing the results in a context that is meaningful to clinicians and patients is often overlooked.
  
  
  OBJECTIVE
  This study sought to quantify the impact of irritable bowel syndrome (IBS) on HRQoL by comparing the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) scores of IBS patients with normative US data and with the scores of patients having other chronic gastrointestinal (GI) and non-GI disorders.
  
  
  METHODS
  Two IBS reference groups were identified from the published literature: a largely untreated community sample of health maintenance organization (HMO) members (N = 92) and a sample of patients with IBS recruited through clinics and in the community (N = 140). SF-36 scores for these groups were compared with published US population norms (N = 2474) and with published scores for 3 other IBS samples (N = 464); a sample with other chronic GI disorders (dyspepsia [N = 126], gastroesophageal reflux disease [GERD] [N = 516]); and samples with other chronic episodic disorders (asthma [N = 375], migraine [N = 303], panic disorder [N = 73], rheumatoid arthritis [N = 693]).
  
  
  RESULTS
  The scores of patients in both IBS reference groups were significantly lower on several SF-36 domains than those of the US normative population (P < 0.003). Scores on several SF-36 scales were also significantly lower in the IBS reference groups compared with the GERD, asthma, and migraine samples (P < 0.003). Depending on the IBS sample used, scores did not differ or were higher compared with those in the sample with dyspepsia. Relative to the samples with panic disorder and rheumatoid arthritis, the IBS groups had significantly higher scores on most SF-36 domains (P < 0.003). Scores for the HMO reference group were generally higher than those for the clinic/community reference group.
  
  
  CONCLUSIONS
  Based on the results of this analysis, IBS is associated with impairment of HRQoL relative to US population norms and to populations with GERD, asthma, or migraine. HRQoL appears to be greater in patients with IBS than in those with panic disorder or rheumatoid arthritis, although the relative symptom severity in these samples was not known.
authors.affiliation: Center for Health Outcomes Research, MEDTAP International, Inc, Bethesda, Maryland 20814, USA. Frank@MEDTAP.com
authors.forename: Lori
authors.initials: L
authors.lastname: Frank
authors.forename: Leah
authors.initials: L
authors.lastname: Kleinman
authors.forename: Anne
authors.initials: A
authors.lastname: Rentz
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Ciesla
authors.forename: John J
authors.initials: JJ
authors.lastname: Kim
authors.forename: Christopher
authors.initials: C
authors.lastname: Zacker
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003109:Colonic Diseases, Functional / Q000523:psychology* / Q000628:therapy; D005260:Female; D005767:Gastrointestinal Diseases / Q000523:psychology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D012016:Reference Values; D016896:Treatment Outcome; D014481:United States