title: Effects of synthetic siderophores on proliferation of Plasmodium falciparum in infected human erythrocytes.
abstract: Because iron is essential for Plasmodium falciparum, we investigated the in vitro potential of various synthetic siderophores to kill P. falciparum in infected human erythrocytes. The substances with the most promising profile, i.e., low 50% lethal doses for plasmodia and minimum toxicity towards mammalian cells, were siderophores with an acylated monocatecholate or a triscatecholate as substituent.
authors.affiliation: Department of Internal Medicine, University Hospital of Innsbruck, University of Innsbruck, A-6020 Innsbruck, Austria.
authors.forename: Andrea
authors.initials: A
authors.lastname: Rotheneder
authors.forename: Gernot
authors.initials: G
authors.lastname: Fritsche
authors.forename: Lothar
authors.initials: L
authors.lastname: Heinisch
authors.forename: Ute
authors.initials: U
authors.lastname: Möllmann
authors.forename: Susanne
authors.initials: S
authors.lastname: Heggemann
authors.forename: Clara
authors.initials: C
authors.lastname: Larcher
authors.forename: Günter
authors.initials: G
authors.lastname: Weiss
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D066298:In Vitro Techniques; D007502:Iron Chelating Agents / Q000494:pharmacology; D020014:K562 Cells; D007928:Lethal Dose 50; D010963:Plasmodium falciparum / Q000187:drug effects*; D017262:Siderophores / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000962:Antimalarials; D007502:Iron Chelating Agents; D017262:Siderophores