title: [The chemical constituents of Goniothalamus howii Merr].
abstract: Two new compounds were isolated from the chloroform soluble fraction of ethanolic extract of bark of Goniothalamus howii Merr. On the basis of their chemical properties and spectral data (MS, UV, IR, 1H and 13CNMR) they were identified as 6S (1R-hydroxy-2R-cinnamyloxyphenethyl) 5, 6-dihydro-5S-hydroxy-2-pyrone named Howiinol A and 6S-(1S, 2R-epoxyphenethyl-5S-cinnamyloxy) 5, 6-dihydro-2-pyrone named Howiinin A. Howiinol A showed significant antitumor activities toward human tumor cell in vitro and in vivo and less toxic.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050.
authors.forename: R
authors.initials: R
authors.lastname: Chen
authors.forename: D
authors.initials: D
authors.lastname: Yu
authors.forename: L
authors.initials: L
authors.lastname: Ma
authors.forename: F
authors.initials: F
authors.lastname: Wu
authors.forename: W
authors.initials: W
authors.lastname: Song
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012510:Sarcoma 180 / Q000188:drug therapy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D011753:Pyrones; C469816:howiinin A; C426486:howiinol A