title: Novel bone antiresorptive approaches.
abstract: Inhibition of bone resorption is a mechanism that has been clinically validated as a means to control bone loss in diseases such as postmenopausal osteoporosis. The development of marketable drugs in this area has resulted in significant clinical benefits; however, improvements can still be made. Several novel antiresorptive mechanisms are currently under consideration in the pharmaceutical industry, which will hopefully result in the development of improved bone antiresorptive therapies.
authors.affiliation: Department of Musculoskeletal Diseases Biology, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA. michael_lark-1@gsk.com
authors.forename: Michael W
authors.initials: MW
authors.lastname: Lark
authors.forename: Ian E
authors.initials: IE
authors.lastname: James
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans
chemical_list: D004164:Diphosphonates