Synthetic route to the GE3 cyclodepsipeptide.
[reaction: see text] A reasonably efficient [2 + 2 + 2] fragment condensation strategy has been developed for assembling the cyclodepsipeptide sector of GE3 that involves 5-7. A Carpino HATU-mediated macrolactamization was used to close the 19-membered cyclodepsipeptide ring.
Hale
Karl J
KJ
The Christopher Ingold Laboratories, Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom. k.j.hale@ucl.ac.uk
Lazarides
Linos
L
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D047630:Depsipeptides; D007202:Indicators and Reagents; D007769:Lactams / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010455:Peptides; D010456:Peptides, Cyclic / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D047630:Depsipeptides; C108551:GE3 compound; D007202:Indicators and Reagents; D007769:Lactams; D010455:Peptides; D010456:Peptides, Cyclic; C056791:A 83586C