title: Priapism associated with zuclopenthixol.
abstract: OBJECTIVE
  To present a single case of zuclopenthixol-induced priapism and a literature review.
  
  
  METHODS
  We report the case of a 31-year-old patient hospitalized due to behavioral alterations and treated with oral zuclopenthixol, an antipsychotic from the thioxanthene family, who developed an acute, painful erection.
  
  
  CONCLUSIONS
  The occurrence of priapism in our patient was related to zuclopenthixol. This adverse reaction is reported for the first time in a patient not concomitantly treated with other drugs associated with the appearance of priapism. The capacity of zuclopenthixol to induce priapism is thought to be due to its antagonist activity on alpha-adrenergic receptors.
  
  
  CONCLUSIONS
  Priapism is an uncommon but potentially serious adverse effect of zuclopenthixol that practitioners, as with many other antipsychotics, should be aware of.
authors.affiliation: Medical Staff, Complejo Asistencial Benito Menni, Ciempozuelos, Spain.
authors.forename: Julio
authors.initials: J
authors.lastname: Salado
authors.forename: Antonio
authors.initials: A
authors.lastname: Blázquez
authors.forename: Raquel
authors.initials: R
authors.lastname: Díaz-Simón
authors.forename: Franciso
authors.initials: F
authors.lastname: López-Muñoz
authors.forename: Cecilio
authors.initials: C
authors.lastname: Alamo
authors.forename: Gabriel
authors.initials: G
authors.lastname: Rubio
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003006:Clopenthixol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000627:therapeutic use; D011317:Priapism / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D003006:Clopenthixol; D009638:Norepinephrine