[Anti-arrhythmic properties of GABA and GABA-ergic system activators].
Clinical and experimental data available in the literature are summarized, which are indicative of the antiarrhythmogenic properties of GABA and substances possessing GABA-positive activity (phenibut, piracetam, sodium hydroxybutyrate, lithium hydroxybutyrate, etc.). The antiarrhythmic effects are manifested in various cases of the heart rhythm violation. The mechanism of this action is related to activation of the central and peripheral retarding GABAergic system, as well as to antihypoxant, antioxidant, and antistressor effects.
Tiurenkov
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Pharmacology and Biopharmacy Chair, Department of Postgraduate Medical Training, Volgograd State Medical Academy, pl. Pavshikh Bortsov 1a, Volgograd, 400066 Russia.
Perfilova
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D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D005609:Free Radicals / Q000378:metabolism; D018755:GABA Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D000860:Hypoxia / Q000517:prevention & control; D015227:Lipid Peroxidation / Q000187:drug effects; D018079:Receptors, GABA / Q000187:drug effects* / Q000502:physiology; D013312:Stress, Physiological / Q000517:prevention & control; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*
D000889:Anti-Arrhythmia Agents; D000975:Antioxidants; D005609:Free Radicals; D018755:GABA Agonists; D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid