title: Factors explaining variance in perceived pain in women with fibromyalgia.
abstract: BACKGROUND
  We hypothesized that a substantial proportion of the subjectively experienced variance in pain in fibromyalgia patients would be explained by psychological factors alone, but that a combined model, including neuroendocrine and autonomic factors, would give the most parsimonious explanation of variance in pain.
  
  
  METHODS
  Psychometric assessment included McGill Pain Questionnaire, General Health Questionnaire, Hospital Anxiety and Depression Rating Scale, Eysenck personality Inventory, Neuroticism and Lie subscales, Toronto Alexithymia Scale, and Multidimensional Health Locus of Control Scale and was performed in 42 female patients with fibromyalgia and 48 female age matched random sample population controls. A subgroup of the original sample (22 fibromyalgia patients and 13 controls) underwent a pharmacological challenge test with buspirone to assess autonomic and adrenocortical reactivity to serotonergic challenge.
  
  
  RESULTS
  Although fibromyalgia patients scored high on neuroticism, anxiety, depression and general distress, only a minor part of variance in pain was explained by psychological factors alone. High pain score was associated with high neuroticism, low baseline cortisol level and small drop in systolic blood pressure after buspirone challenge test. This model explained 41.5% of total pain in fibromyalgia patients. In population controls, psychological factors alone were significant predictors for variance in pain.
  
  
  CONCLUSIONS
  Fibromyalgia patients may have reduced reactivity in the central sympathetic system or perturbations in the sympathetic-parasympathetic balance. This study shows that a biopsychosocial model, including psychological factors as well as factors related to perturbations of the autonomic nervous system and hypothalamic-pituitary-adrenal axis, is needed to explain perceived pain in fibromyalgia patients.
authors.affiliation: Department of Psychiatry, University of Bergen Haukeland University Hospital, N-5022 Bergen, Norway. eva.albertsen@psych.uib.no
authors.forename: Eva Albertsen
authors.initials: EA
authors.lastname: Malt
authors.forename: Snorri
authors.initials: S
authors.lastname: Olafsson
authors.forename: Anders
authors.initials: A
authors.lastname: Lund
authors.forename: Holger
authors.initials: H
authors.lastname: Ursin