title: [Diagnostic and therapeutic problems in adult onset Still's disease (data of a long-term follow-up)].
abstract: 15 patients with Still's disease of adults (SDA) were followed up for 17 years maximum. The disease showed a principal clinical-laboratory syndrome observed both in SDA debut and exacerbations (recurrences). Clinical manifestations of SDA do not arise stereotypically causing difficulties in its nosological interpretation. SDA course is represented by three variants: monophasic (monocyclic), recurrent and chronic persisting with development of destructive arthritis. Use of nonsteroid antiinflammatory drugs is analysed, indications to administration of glucocorticoids and basic treatment are listed. Reversibility of systemic SDA manifestations except the articular one is shown. About half of the patients develop chronic destructive arthritis. In active SDA, renal amyloidosis and chronic renal failure may develop with lethal outcome.
authors.forename: E N
authors.initials: EN
authors.lastname: Nemchinov
authors.forename: M Z
authors.initials: MZ
authors.lastname: Kanevskaia
authors.forename: I N
authors.initials: IN
authors.lastname: Bokarev
mesh_terms: D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*; D012720:Severity of Illness Index; D016706:Still's Disease, Adult-Onset / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone