New eremophilenolides from Ligulariopsis shichuana.
Four new eremophilenolides, 1-4, have been isolated from the whole plant of Ligulariopsis shichuana. Their structures were elucidated by spectroscopic methods, including 2D NMR experiments. Structures of compounds 1 and 2 were unequivocally established by X-ray diffraction experiments. All of these sesquiterpenes have eremophilane skeletons with 7(11)-en-8(12) lactone units. Compounds 1 and 2 showed moderate antibacterial activities against E. coli and B. subtilis.
Wang
Wenshu
W
National Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
Gao
Kun
K
Jia
Zhongjian
Z
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D001412:Bacillus subtilis / Q000187:drug effects; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D007783:Lactones; D012717:Sesquiterpenes