The polyphenol chlorogenic acid inhibits staphylococcal exotoxin-induced inflammatory cytokines and chemokines.
Proinflammatory cytokines mediate the toxic effect of staphylococcal exotoxins (SE). Chlorogenic acid, a plant polyphenol, inhibited SE-induced T-cell proliferation (by 98%) and production of interleukin 1beta, tumor necrosis factor, interleukin 6, interferon gamma, monocyte chemotactic protein I (MCP-l), macrophage inflammatory protein (MIP)-lalpha, and MIP-lbeta by human peripheral blood mononuclear cells. These data indicate that chlorogenic acid may be therapeutically useful for mitigating the pathogenic effects of SE. Naturally occurring polyphenolic compounds such as chlorogenic acid may serve as a potent anti-inflammatory agent alternative to conventional chemotherapeutics.
Krakauer
Teresa
T
United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011, USA.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001427:Bacterial Toxins; D002455:Cell Division / Q000187:drug effects; D018925:Chemokines / Q000037:antagonists & inhibitors*; D002726:Chlorogenic Acid / Q000494:pharmacology*; D003583:Cytokinins / Q000037:antagonists & inhibitors*; D004768:Enterotoxins / Q000633:toxicity*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D018089:Superantigens
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001427:Bacterial Toxins; D018925:Chemokines; D003583:Cytokinins; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; D002726:Chlorogenic Acid; C031818:enterotoxin B, staphylococcal