[Effects of tea polyphenols on microcirculation and antioxidation in aircrew].
OBJECTIVE
To study the effects of tea polyphenols (TP) on bulbi conjunctiva microcirculation (BCM) and antioxidation in aircrew and find out the proper antioxidant for the health protection of aircrew.


METHODS
Fourty healthy aircrew were divided into TP group (TP 600 mg/d.po) and control group (placebo) randomly. The effects of TP on microcirculation and antioxidation in aircrew were tested after 20 days.


RESULTS
Red blood cell (RBC) superoxide dismutase (SOD) activity and GSH-PX (Whole blood glutathione peroxidase)/MDA (serum malondialdehyde) ratio in TP group were significantly higher than those in control (P<0.01), and serum MDA level was significantly decreased after TP administration (P<0.05). The numbers of capillaries and blood flow in micrangium were significantly increased, RBC aggregation, ischemia area and A (arteriole)/V (venule) ratio were remarkably decreased in TP group (P<0.01). The total integral value of microcirculation in TP group was significantly reduced in comparison with that in the control group.


CONCLUSIONS
TP can significantly increase the antioxidative ability of aircrew, decrease the BCM disturbance and improve the microcirculatory function.
Luo
X M
XM
East-Lake Sanatorium of Air Force, Wuhan, China.
Hu
Y H
YH
Yu
J
J
Wang
H
H
Xu
Q Y
QY
Zhan
H
H
D000328:Adult; D000337:Aerospace Medicine; D000975:Antioxidants / Q000494:pharmacology*; D003228:Conjunctiva / Q000187:drug effects*; D005419:Flavonoids; D005979:Glutathione Peroxidase / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D008833:Microcirculation / Q000187:drug effects*; D010636:Phenols / Q000494:pharmacology*; D011108:Polymers / Q000494:pharmacology*; D059808:Polyphenols; D013482:Superoxide Dismutase / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D013662:Tea / Q000737:chemistry*
D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D013662:Tea; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase