title: Impact of intravenous nicotine on BOLD signal response to photic stimulation.
abstract: Functional magnetic resonance imaging (fMRI) is increasingly being applied in the study of brain effects of nicotine. In addition, because tobacco smoking is common, many subjects studied with fMRI for other reasons may have appreciable levels of nicotine in plasma and brain during scanning. However, there is concern that the vascular effects of nicotine may alter the coupling between blood oxygen level dependent (BOLD) signal and neuronal activity. The objective of this study was to test for evidence of alteration of BOLD signal response of occipital cortex, a region with a relatively low concentration of neuronal nicotine receptors, to photic stimulation during intravenous infusion of nicotine. Nine nicotine dependent healthy smokers were withdrawn from nicotine under controlled conditions and then scanned while receiving photic stimulation and successive intravenous infusions of saline and nicotine. No evidence for an effect of nicotine on BOLD signal response to photic stimulation was detected at the doses studied. This observation suggests that nicotine does not alter the coupling between BOLD signal and neuronal activity in the visual cortex.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA. leslie.jacobsen@yale.edu
authors.forename: Leslie K
authors.initials: LK
authors.lastname: Jacobsen
authors.forename: John C
authors.initials: JC
authors.lastname: Gore
authors.forename: Pawel
authors.initials: P
authors.lastname: Skudlarski
authors.forename: Cheryl M
authors.initials: CM
authors.lastname: Lacadie
authors.forename: Peter
authors.initials: P
authors.lastname: Jatlow
authors.forename: John H
authors.initials: JH
authors.lastname: Krystal
mesh_terms: D006801:Humans; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D009538:Nicotine / Q000494:pharmacology*; D010775:Photic Stimulation; D014793:Visual Cortex / Q000187:drug effects*
chemical_list: D009538:Nicotine