[Lipids of lymphocyte plasma membranes in patients with atherosclerosis and their children].
Phospholipid composition and activity of 5'nucleotidase of lymphocyte plasmatic membranes were studied in patients with atherosclerosis (AS) and their children. The content of phosphatidylcholine, cholesterol/total phospholipid ratio, transmembrane asymmetry of lipids were increased, 5'nucleotidase activity decreased, and lymphocyte plasmatic membranes contained accumulations of lisophospholipids (LPL). This indicated increased hydrophobia and decreased functional activity and damage of lymphocyte plasmatic membranes. Increased transmembrane lipid asymmetry and LPL accumulations were detected in the lymphocyte plasmatic membranes of children with aggravated heredity for AS. Presumably these disorders anticipate the changes in the structure of plasmatic membranes, observed in adult patients with AS, and progress in case of exposure to unfavorable factors.
Ryzhova
L M
LM
Sukhanova
G A
GA
Kovalev
I A
IA
Filippov
G P
GP
D015720:5'-Nucleotidase / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D002462:Cell Membrane / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry*; D008297:Male; D008563:Membrane Lipids / Q000097:blood / Q000737:chemistry*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications
D008563:Membrane Lipids; D015720:5'-Nucleotidase