title: [Effect of Gastrodia on rotation induced motion sickness in mice].
abstract: OBJECTIVE
  To observe the effect of Gastrodia on motion sickness induced by rotation in mice.
  
  
  METHODS
  Clockwise and anticlockwise accelerated rotations up to 180 degrees/s for 10 min were used to induce symptoms of motion sickness such as condition taste aversion (CTA), decrease of spontaneous locomotion and impaired ability of space identification in water-maze.
  
  
  RESULTS
  Gastrodia could improve the response of CTA, increase spontaneous locomotion, and enhance the ability of learning and memory in water-maze in mice after the rotation.
  
  
  CONCLUSIONS
  Symptoms of motion sickness induced by rotation could be improved by Gastrodia treatment.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: S P
authors.initials: SP
authors.lastname: Wang
authors.forename: X M
authors.initials: XM
authors.lastname: Liu
authors.forename: W F
authors.initials: WF
authors.lastname: Shang
authors.forename: J
authors.initials: J
authors.lastname: Song
authors.forename: S R
authors.initials: SR
authors.lastname: Yu
authors.forename: S M
authors.initials: SM
authors.lastname: Sun
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use*; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D009041:Motion Sickness / Q000188:drug therapy* / Q000209:etiology; D009043:Motor Activity / Q000187:drug effects; D012399:Rotation / Q000009:adverse effects*; D013037:Spatial Behavior / Q000187:drug effects; D013649:Taste / Q000187:drug effects; D014867:Water
chemical_list: D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D014867:Water