Complex-trait genetics: emergence of multivariate strategies.
Complex traits, including many disease-related traits, are influenced by multiple genes. Bivariate approaches that associate one gene with one trait are yielding to multivariate methods to synthesize the effects of multiple genes, integrate results across independent studies, and aid in the identification of coordinated pathways and interactions between loci.
Phillips
Tamara J
TJ
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97201, USA. phillipt@ohsu.edu
Belknap
John K
JK
D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics*; D002874:Chromosome Mapping; D016000:Cluster Analysis; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D023281:Genomics; D006801:Humans; D020412:Multifactorial Inheritance / Q000235:genetics*; D015999:Multivariate Analysis; D009154:Mutation / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis