Circling mouse, a spontaneous mutant in the inner ear.
A spontaneous mutant was established in the ICR mouse strain. The affected mice became hyperactive at about 7 days of age, and then showed circling behavior. The body weight decreased significantly 2 weeks after birth, and developmental defects were revealed in the middle ear, cochlea, cochlear nerve, and semicircular canal areas. The mutation was inherited by an autosomal single recessive gene and is referred to as cir.
Lee
Jeong Woong
JW
Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College, Seoul 137-701, Korea.
Ryoo
Zae Young
ZY
Lee
Eun Ju
EJ
Hong
Sung Hwa
SH
Chung
Won Ho
WH
Lee
Hoon Taek
HT
Chung
Kil Saeng
KS
Kim
Tae Yoon
TY
Oh
Yang Seok
YS
Suh
Jun Gyo
JG
D000818:Animals; D001522:Behavior, Animal; D001835:Body Weight; D003051:Cochlea / Q000002:abnormalities; D007758:Ear, Inner / Q000002:abnormalities*; D005260:Female; D005808:Genes, Recessive; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008817:Mice, Mutant Strains / Q000033:anatomy & histology / Q000235:genetics* / Q000502:physiology; D010375:Pedigree; D010641:Phenotype