Additional cytotoxic diacetylenes from the stony coral Montipora sp.
Three new diacetylenes (1, 4, 6) have been isolated as cytotoxic constituents from the methanolic extract of the stony coral Montipora sp. The structures have been elucidated on the basis of spectroscopic evidence. The compounds were evaluated for cytotoxicity against a small panel of human tumor cell lines and showed moderate to significant activity.
Alam
Naseer
N
College of Pharmacy, Pusan National University, Korea.
Hong
Jongki
J
Lee
Chong-Ok
CO
Choi
Jae Sue
JS
Im
Kwang Sik
KS
Jung
Jee H
JH
D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D001156:Artemia; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy
D000970:Antineoplastic Agents; D000114:Acetylene