title: An experimental study of some indigenous drugs with special reference to hydraulic permeability.
abstract: The effect of commonly used indigenous drugs for hepatic disorders i.e. Tinospora cordifolia, (Guduchi/Amrita), Andrographis paniculata (Kalmegha), Picrorhiza kurroa (Kutki), Phyllantnus niruri (Bhoomyamalaki) and Berberis aristata (Daruharidra) was tested on the hydraulic permeability of water in the presence of bile salt through a transport cell model. The data on hydraulic permeability were calculated as t (time). JV = Lp x AP, where Lp = hydraulic conductivity and AP is the pressure difference. It was observed that the value of controlled hydraulic permeability (0.49 x 10(-8) M3 S(-1) N(-1)) decreased in the presence of indigenous drugs and bile salt. The results suggest that these drugs might have the cell membrane stabilizing property which may lead to prevention of the toxic effect of bile salts in various hepatic disorders.
authors.affiliation: Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
authors.forename: L
authors.initials: L
authors.lastname: Upadhyay
authors.forename: A
authors.initials: A
authors.lastname: Mehrotra
authors.forename: A K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: N P
authors.initials: NP
authors.lastname: Rai
authors.forename: K
authors.initials: K
authors.lastname: Tripathi
mesh_terms: D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy*; D010539:Permeability; D010599:Pharmacokinetics; D010936:Plant Extracts / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D010936:Plant Extracts