title: Additional cytotoxic diacetylenes from the stony coral Montipora sp.
abstract: Three new diacetylenes (1, 4, 6) have been isolated as cytotoxic constituents from the methanolic extract of the stony coral Montipora sp. The structures have been elucidated on the basis of spectroscopic evidence. The compounds were evaluated for cytotoxicity against a small panel of human tumor cell lines and showed moderate to significant activity.
authors.affiliation: College of Pharmacy, Pusan National University, Korea.
authors.forename: Naseer
authors.initials: N
authors.lastname: Alam
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Chong-Ok
authors.initials: CO
authors.lastname: Lee
authors.forename: Jae Sue
authors.initials: JS
authors.lastname: Choi
authors.forename: Kwang Sik
authors.initials: KS
authors.lastname: Im
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D001156:Artemia; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000970:Antineoplastic Agents; D000114:Acetylene