Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.
We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.
Li
Jing
J
Tularik Inc., Genomics Division, 266 Pulaski Road, Greenlawn, New York, USA.
Yang
Ying
Y
Peng
Yue
Y
Austin
Richard J
RJ
van Eyndhoven
Winfried G
WG
Nguyen
Ken C Q
KC
Gabriele
Tim
T
McCurrach
Mila E
ME
Marks
Jeffrey R
JR
Hoey
Timothy
T
Lowe
Scott W
SW
Powers
Scott
S
D017209:Apoptosis / Q000235:genetics; D001943:Breast Neoplasms / Q000209:etiology / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005260:Female; D005784:Gene Amplification; D006801:Humans; D009363:Neoplasm Proteins; D009857:Oncogenes / Q000235:genetics; D010749:Phosphoprotein Phosphatases / Q000235:genetics*; D000071636:Protein Phosphatase 2C
D009363:Neoplasm Proteins; C000607458:PPM1D protein, human; D010749:Phosphoprotein Phosphatases; D000071636:Protein Phosphatase 2C