title: [Immunogenicity of retina in mice].
abstract: OBJECTIVE
  To evaluate the immunogenicity of retina.
  
  
  METHODS
  DBA/2 mice (MHCH-2d) were used as donors, C57BL/6 mice (MHC H-2d) or BALB/C mice (MHC H-2d) as recipients. Half retina of DBA/2 mouse was transplanted subcutaneously to a C57BL/6 or BALB/C mouse. The delayed-type hypersensitivity (DTH) and specific killing rate of cytotoxic T lymphocyte(CTL) were detected two weeks later.
  
  
  RESULTS
  The results of DTH and specific killing rate of CTL in the retina of DBA/2 mice were significantly lower than the positive group(P < 0.01), but significantly higher than the negative group(P < 0.01).
  
  
  CONCLUSIONS
  MHC Class I and Class II antigen and minor histocompatibility complex antigen(Minor HC) are expressed in the retina of the DBA/2 mouse, which stimulates immune system of recipient to produce weak cellular immune response. It is suggested that the retina has weak immunogenicity.
authors.affiliation: Department of Ophthalmology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
authors.forename: L
authors.initials: L
authors.lastname: Gao
authors.forename: D
authors.initials: D
authors.lastname: Jiang
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic; D005260:Female; D006968:Hypersensitivity, Delayed; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012160:Retina / Q000276:immunology* / Q000637:transplantation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*