Description of six new HLA-B alleles in the 5C CREG including a B*58 intron two sequence.
Five of the six novel HLA-B alleles described in this report contain polymorphic motifs previously reported in HLA-B alleles, suggesting an origin resultant from a gene conversion mechanism. The sixth allele, B*35012, contains a polymorphism previously unreported in HLA-B molecules. In addition to previously reported polymorphisms, B*5806 carries a previously unreported intronic substitution in a sequencing primer annealing site.
Gans
C P
CP
Department of Oncology, Georgetown University Medical Center, Washington, DC 2007, USA.
Mitton
W
W
Ng
J
J
Hartzman
R J
RJ
Hurley
Carolyn K
CK
D000483:Alleles; D001483:Base Sequence; D003429:Cross Reactions; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
D015235:HLA-B Antigens