Multifocal choroiditis after allogenic bone marrow transplantation.
OBJECTIVE
To describe the clinical manifestations of multifocal choroiditis presumed to be secondary to allogenic bone marrow transplantation after development of self-tolerance to chronic graft-versus-host disease (GVHD).


METHODS
Case report. A 17-year-old male who received an allogenic bone marrow transplant (BMT) from his HLA-identical sister.


RESULTS
One year after BMT, grade II chronic GVHD developed. Two years later, vision deteriorated to 20/50 R.E. and 20/400 L.E. Ophthalmoscopic examination showed multiple chorioretinal punched-out scars throughout the posterior pole and mid-periphery of both eyes. Fluorescein angiography showed four choroidal neovascular membranes (CNVMs) in the right eye that were surgically removed, and a subfoveal disciform scar in the left eye.


CONCLUSIONS
Multifocal choroiditis is a possible complication related to allogenic BMT. It should be included as a late cause of BMT-associated choroidopathy. Surgical removal of vision-threatening CNVMs is a reasonable approach.
Alvarez
M T
MT
Department of Ophthalmology, Ramón y Cajal University Hospital, Madrid, Spain.
Hernáez
J M
JM
Ciancas
E
E
Figueroa
M S
MS
D000293:Adolescent; D015551:Autoimmunity; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D020256:Choroidal Neovascularization / Q000209:etiology / Q000601:surgery; D002833:Choroiditis / Q000209:etiology* / Q000473:pathology; D005451:Fluorescein Angiography; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D016399:Lymphoma, T-Cell / Q000628:therapy; D008297:Male; D014184:Transplantation, Homologous; D014792:Visual Acuity