A case of NK/T-cell lymphoma complicated by a squamous cell carcinoma of hard palate during combination chemotherapy and radiation therapy.
NK/T-cell lymphoma, which often shows an angiocentric growth pattern, is a distinct clinicopathologic entity highly associated with Epstein-Barr virus. The disease is characterized by a destruction of the upper respiratory tract, particularly the nasal cavity, palate and paranasal sinuses. Interestingly, NK/T-cell lymphoma is closely linked to a variety of complications, such as hemophagocytic syndrome, second primary cancer, sepsis and bleeding. Here we report a case of a 50-year-old man diagnosed initially as NK/T-cell lymphoma of the oropharynx and who developed a second primary carcinoma of the hard palate during combination chemotherapy and radiation therapy.
Lee
Hang Lak
HL
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Ahn
Myung Ju
MJ
Choi
Jung Hye
JH
Jun
Woon Hyun
WH
Lee
Young Yuel
YY
Kim
In Soon
IS
Choi
Il Young
IY
Jang
Se Jin
SJ
Park
Yong Wook
YW
D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D007694:Killer Cells, Natural; D016399:Lymphoma, T-Cell / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000628:therapy; D009959:Oropharyngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D010157:Palatal Neoplasms / Q000473:pathology* / Q000628:therapy