Diastolic filling abnormalities by color kinesis in newborns exposed to intrauterine cocaine.
Because cocaine crosses the placenta, we prospectively evaluated global and segmental systolic and diastolic cardiac function by color kinesis in clinically asymptomatic newborns who were exposed to cocaine in utero (group 1, n = 82). Their data were compared with normal controls (group 3, n = 87) and newborns exposed to drugs other than cocaine (group 2, n = 108). During left ventricular filling, newborns exposed to cocaine, compared with groups 2 and 3, had significantly (P <.05) higher global fractional area change (%) (76 +/- 10.3 vs 72 +/- 9.4 and 72 +/- 9.1, respectively), regional fractional area changes (%) for the anterior, septal, inferior, and lateral wall, and in the index of asynchrony (at 50% filling 13.2 +/- 5.8 vs 11.3 +/- 4.1 and 11.6 +/- 4.2, respectively). There were no significant differences in systolic function among the 3 groups. Prenatal cocaine exposure in asymptomatic infants leads to higher global and segmental fractional area changes and asynchrony during diastole. The significance and course of these alterations require further investigation.
Mehta
Sudhir Ken
SK
Department of Pediatrics, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio, USA. Ken.mehta@fairviewhospital.org
Super
Dennis M
DM
Salvator
Ann
A
Singer
Lynn
L
Connuck
David
D
Fradley
Linda Goetz
LG
Harcar-Sevcik
Rose A
RA
Thomas
James D
JD
Sun
Jing Ping
JP
D003042:Cocaine / Q000633:toxicity*; D003971:Diastole / Q000502:physiology; D018618:Echocardiography, Doppler, Color; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011446:Prospective Studies; D016277:Ventricular Function, Left / Q000187:drug effects*
D003042:Cocaine