title: New metabolites from sponge-derived fungi Curvularia lunata and Cladosporium herbarum.
abstract: The fungus Curvularia lunata, isolated from the marine sponge Niphates olemda, yielded the new 1,3,8-trihydroxy-6-methoxyanthraquinone, which we named lunatin (1), the known modified bisanthraquinone cytoskyrin A (2), and the known plant hormone (+)-abscisic acid (3). Both anthraquinones were found to be active against Bacillus subtilis, Staphylococcus aureus, and Escherichia coli. Two strains of the fungus Cladosporium herbarum, isolated from the sponges Aplysina aerophoba and Callyspongia aerizusa, respectively, yielded two new alpha-pyrones, herbarin A (4) and herbarin B (5), the known compound citreoviridin A (6), and the new phthalide herbaric acid (7). All structures were unambiguously established by 1D and 2D NMR and MS data.
authors.affiliation: Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsststrasse 1, Geb.26.23, D-40225 Düsseldorf, Germany.
authors.forename: Raquel
authors.initials: R
authors.lastname: Jadulco
authors.forename: Gernot
authors.initials: G
authors.lastname: Brauers
authors.forename: Ru Angelie
authors.initials: RA
authors.lastname: Edrada
authors.forename: Rainer
authors.initials: R
authors.lastname: Ebel
authors.forename: Victor
authors.initials: V
authors.lastname: Wray
authors.forename: Sudarsono
authors.initials: S
authors.lastname: Sudarsono
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000040:Abscisic Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002855:Chromatography, Thin Layer; D004926:Escherichia coli / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005658:Fungi / Q000737:chemistry*; D007214:Indonesia; D008522:Mediterranean Sea; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera; D018411:Spodoptera / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: C460121:1,3,8-trihydroxy-6-methoxyanthraquinone; D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; C419462:cytoskyrin A; D000040:Abscisic Acid