title: Expeditious syntheses of two carbohydrate-linked cisplatin analogs.
abstract: The syntheses of two carbohydrate-linked cisplatin analogs, namely lacto- and alpha-Gal-cisplatin, are described. A fusion enzymatic approach was used to create the diazido-alpha-Gal trisaccharide intermediate in the synthesis of alpha-Gal-cisplatin.
authors.affiliation: Department of Chemistry, Wayne State University, 373 Chemistry, Detroit, MI 48202, USA.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Chen
authors.forename: Adam
authors.initials: A
authors.lastname: Janczuk
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Wang
authors.forename: Mohamad
authors.initials: M
authors.lastname: Ksebati
authors.forename: Peng George
authors.initials: PG
authors.lastname: Wang
mesh_terms: D002240:Carbohydrate Sequence; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D005700:Galactosyltransferases / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D014534:UDPglucose 4-Epimerase / Q000378:metabolism
chemical_list: D011993:Recombinant Fusion Proteins; D005700:Galactosyltransferases; D014534:UDPglucose 4-Epimerase; C020551:galactose epimerase; D002945:Cisplatin