title: Olfactory neuroepithelioma in a dog: an immunohistochemical and electron microscopic study.
abstract: A case of olfactory neuroepithelioma was investigated electron microscopically and immunohistochemically. The tumor mass was found in the nasal cavities of a 10-year-old female dog, which showed epistaxis, nasal discharge and facial swelling. The tumor tissue consisted of tubular structure of cuboidal to columnar cells and compactly arranged nests of small cells surrounded by a fibrovascular stroma. Mitotic figures were frequently observed. Immunohistochemically, the tumor cells frequently showed positive for neurofilament protein, synaptophysin and/or carnosine in addition to keratin. Ultrastructurally, tight junction was observed between the tumor cells. No dense-cored secretory granules were shown in the tumor cells. These findings indicated that the present tumor had neuronal and epithelial features probably originating from the olfactory epithelium.
authors.affiliation: Department of Veterinary Pathology, Tottori University, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Hara
authors.forename: Akinori
authors.initials: A
authors.lastname: Shimada
authors.forename: Takehito
authors.initials: T
authors.lastname: Morita
authors.forename: Masumi
authors.initials: M
authors.lastname: Sawada
authors.forename: Takashi
authors.initials: T
authors.lastname: Umemura
mesh_terms: D000818:Animals; D002336:Carnosine / Q000378:metabolism; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D007633:Keratins / Q000378:metabolism; D008854:Microscopy, Electron / Q000662:veterinary; D009296:Nasal Cavity / Q000473:pathology; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D016900:Neurofilament Proteins / Q000378:metabolism; D009669:Nose Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D016900:Neurofilament Proteins; D016708:Synaptophysin; D007633:Keratins; D002336:Carnosine