title: Oral treatment with Lactococcus lactis expressing Staphylococcus hyicus lipase enhances lipid digestion in pigs with induced pancreatic insufficiency.
abstract: The Staphylococcus hyicus lip gene was cloned in Lactococcus lactis. Pancreatic insufficiency was induced by ligation of the pancreatic duct in pigs. In pigs who had undergone pancreatic ligation, the coefficient of fat absorption was higher after consumption of lipase-expressing L. lactis (91.9% +/- 3.7%) than that after consumption of the inactive control strain (78.4% +/- 2.4%).
authors.affiliation: Unité d'Ecologie et de Physiologie du Systeme Digestif, Institut National de la Recherche Agronomique, 78350 Jouy en Josas, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Drouault
authors.forename: Catherine
authors.initials: C
authors.lastname: Juste
authors.forename: Philippe
authors.initials: P
authors.lastname: Marteau
authors.forename: Pierre
authors.initials: P
authors.lastname: Renault
authors.forename: Gérard
authors.initials: G
authors.lastname: Corthier
mesh_terms: D000818:Animals; D004064:Digestive System / Q000382:microbiology; D004195:Disease Models, Animal; D013294:Lactococcus lactis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008026:Ligation; D008049:Lipase / Q000235:genetics / Q000378:metabolism*; D050356:Lipid Metabolism; D010182:Pancreatic Diseases / Q000378:metabolism / Q000628:therapy*; D010183:Pancreatic Ducts; D019936:Probiotics; D013210:Staphylococcus / Q000201:enzymology; D013552:Swine; D014162:Transfection
chemical_list: D008049:Lipase