Protein modulators made to order.
Small molecules were created by diversity-oriented synthesis and subsequently subjected to microarray-based screening for their ability to bind a protein of interest. This general two-step method proved powerful in generating highly specific modulators of protein function.
Chen
Jie
J
Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
D018797:Cell Cycle Proteins; D004146:Dioxanes / Q000378:metabolism / Q000494:pharmacology; D015195:Drug Design; D005656:Fungal Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D005979:Glutathione Peroxidase; D010080:Oxazoles / Q000378:metabolism / Q000494:pharmacology; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors / Q000378:metabolism; D011328:Prions; D011485:Protein Binding; D011506:Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D020123:Sirolimus / Q000378:metabolism / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D018797:Cell Cycle Proteins; D004146:Dioxanes; D005656:Fungal Proteins; D010080:Oxazoles; D011328:Prions; D011506:Proteins; D029701:Saccharomyces cerevisiae Proteins; C454543:uretupamine A; C454542:uretupamine B; D005979:Glutathione Peroxidase; C067020:URE2 protein, S cerevisiae; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); C083324:TOR1 protein, S cerevisiae; D020123:Sirolimus