[Effect of natural nootropic and adaptogen preparations on the cortex bioelectrical activity in rats].
The influence of new nootrope and adaptogen preparations representing dry extracts from Scutellaria baicalensis (Georgi), Bergenia crassifolia (Fritsch), and velvet antlers of Siberian deer (Cervus elaphus sibiricus) on the bioelectric activity (cortex Fourier spectral EEG power) under conflict situation and conditioned reflex development was studied in rats. In both tests, the drugs produced similar changes in the EEG activity: (i) increase in the partial contribution of delta-activity and general spectral power, (ii) depression in the alpha and beta 1-rhythm power, (iii) depression of theta-activity in some cases. The EEG activity changes depended on the initial state and were closely connected with the behavior of the test animals. The drug administration led to normalization of the alpha and beta 1 activity correlated with the improved behavioral characteristics. At the same time, the delta activity was virtually not affected and lost the correlation with behavior.
Suslov
N I
NI
Laboratory of Pathophysiology and Experimental Therapy, Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
Churin
A A
AA
Skurikhin
E G
EG
Provalova
N V
NV
Stal'bovskiĭ
A O
AO
Litvinenko
V I
VI
Dygaĭ
A M
AM
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects; D003220:Conflict, Psychological; D003670:Deer; D004327:Drinking Behavior / Q000187:drug effects; D004569:Electroencephalography; D019686:Lamiaceae / Q000737:chemistry; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D018697:Nootropic Agents / Q000494:pharmacology*; D028321:Plant Preparations / Q000494:pharmacology*; D051381:Rats; D014020:Tissue Extracts / Q000494:pharmacology*
D018697:Nootropic Agents; D028321:Plant Preparations; D014020:Tissue Extracts