title: Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040 II. Structure elucidation and biosynthesis.
abstract: The simocyclinones D4 (1) and D8 (2), members of a novel class of antibiotics, were isolated from the mycelial extract of Streptomyces antibioticus Tü 6040 and consist of angucyclinone, deoxysugar, octatetraene dicarboxylate and aminocoumarin structural elements. The structure elucidation was done by one and two dimensional NMR experiments, and other spectroscopic methods in combination with incorporation experiments using 13C labelled precursors.
authors.affiliation: Institut für Organische Chemie, Universität Göttingen, Germany.
authors.forename: Meike
authors.initials: M
authors.lastname: Holzenkämpfer
authors.forename: Martina
authors.initials: M
authors.lastname: Walker
authors.forename: Axel
authors.initials: A
authors.lastname: Zeeck
authors.forename: Judith
authors.initials: J
authors.lastname: Schimana
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification; D006027:Glycosides / Q000096:biosynthesis* / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013303:Streptomyces antibioticus / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D003374:Coumarins; D006027:Glycosides; C416815:simocyclinone D4; C416814:simocyclinone D8