Isolation and identification of dihydrochrysanolide and its 1-epimer from Chrysanthemum coronarium L.
A new sesquiterpene lactone (1) was isolated with known dihydrochrysanolide derivatives (2 and 3) from the flowers of Chrysanthemum coronarium L., and their structures were identified by spectroscopic data. The stereochemistry of the epimers (1 and 2) was determined from NOESY data and an X-ray crystallographic analysis. The isolated compounds (1-3) were examined for their cytotoxic activity against such human cell lines as A549, PC-3 and HCT-15.
Lee
Kyung Dong
KD
Department of Agricultural Chemistry, Gyeongsang National University, Chinju, Korea.
Yang
Min Suk
MS
Ha
Tae Jung
TJ
Park
Ki Min
KM
Park
Ki Hun
KH
D031202:Chrysanthemum / Q000737:chemistry*; D018360:Crystallography, X-Ray; D035263:Flowering Tops / Q000737:chemistry; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism
C493683:1-epi-dihydrochrysanolide; D007783:Lactones; D012717:Sesquiterpenes; C493682:dihydrochrysanolide