title: A case of neurotoxicity following 5-fluorouracil-based chemotherapy.
abstract: 5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent. However, its neurotoxicity is rare and not well recognized. We report a case of 5-FU neurotoxicity with organic brain syndrome and progression to multifocal leukoencephalopathy in a 44-year-old male patient having malignant gastrointestinal stromal tumor. 5-FU-induced neurotoxicity should, therefore, be considered as an important differential diagnosis in cancer patients with neurological abnormality and history of chemotherapy.
authors.affiliation: Department of Internal Medicine, Korea Cancer Center Hospital, 215-4 Gongneung Dong, Nowon Ku, 139-240, Seoul, Korea.
authors.forename: Seung Seog
authors.initials: SS
authors.lastname: Ki
authors.forename: Jin Mo
authors.initials: JM
authors.lastname: Jeong
authors.forename: Seong Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Sook Hyang
authors.initials: SH
authors.lastname: Jeong
authors.forename: Jin Hyuk
authors.initials: JH
authors.lastname: Lee
authors.forename: Chul Ju
authors.initials: CJ
authors.lastname: Han
authors.forename: You Cheol
authors.initials: YC
authors.lastname: Kim
authors.forename: Jhin Oh
authors.initials: JO
authors.lastname: Lee
authors.forename: Young Joon
authors.initials: YJ
authors.lastname: Hong
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D004569:Electroencephalography; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000209:etiology*
chemical_list: D005472:Fluorouracil