title: In-vitro activity of cefpodoxime proxetil (RU 51807): a comparative disk diffusion study on isolates from geriatric patients.
abstract: 997 strains isolated from clinical specimens arrived at the "Pio Albergo Trivulzio" microbiology laboratory were tested using disks of cefpodoxime, amoxicillin + clavulanic acid, cefaclor, cefuroxime, ofloxacin, cotrimoxazole, ceftriaxone and cefalexin. Gram-positive strains were tested also with erythromycin, while gram-negative bacteria were tested against aztreonam. Cefpodoxime overall activity was well above the effectiveness of the other oral cephalosporins and on the same order as ceftriaxone and ofloxacin. Cefpodoxime proved to be also more active than the combination amoxicillin-clavulanic acid.
authors.affiliation: Istituto Geriatrico Pio Albergo Trivulzio, Milano, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Ottomano
authors.forename: S
authors.initials: S
authors.lastname: Frugoni
authors.forename: A
authors.initials: A
authors.lastname: Berlusconi
authors.forename: G
authors.initials: G
authors.lastname: Miseferi
authors.forename: R
authors.initials: R
authors.lastname: Mattina
authors.forename: M
authors.initials: M
authors.lastname: Anelli
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000494:pharmacology*; D015194:Diffusion Chambers, Culture; D006801:Humans; D008826:Microbial Sensitivity Tests; D000097627:Cefpodoxime Proxetil
chemical_list: D000900:Anti-Bacterial Agents; D015296:Ceftizoxime; D000097627:Cefpodoxime Proxetil