title: [How poliomyelitis is to be eradicated completely].
abstract: In 1988 the World Health Assembly resolved to eradicate poliomyelitis globally by the year 2000. The work continues. The problem arose how to quit the system of mass immunization with oral poliovirus vaccine (OPV) without trouble and to achieve the disappearance of polioviruses worldwide. After the cessation of the OPV use a certain number of vaccine viruses may remain that will circulate among the ever growing number of nonimmune population. Live enterovirus vaccines prepared from nonpathogenic serotypes of ECHO virus are proposed for application to stop the circulation of vaccine poliovirus. These vaccines will make it possible to eliminate the remaining vaccine viruses from circulation and to complete the process of worldwide poliomyelitis eradication.
authors.affiliation: Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia.
authors.forename: V B
authors.initials: VB
authors.lastname: Seĭbil'
mesh_terms: D003140:Communicable Disease Control / Q000379:methods*; D004196:Disease Outbreaks / Q000517:prevention & control*; D029822:Enterovirus B, Human / Q000145:classification / Q000276:immunology; D014943:Global Health; D006801:Humans; D017589:Immunization Programs; D011051:Poliomyelitis / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D017955:Poliovirus; D011054:Poliovirus Vaccine, Inactivated / Q000276:immunology; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects; D011159:Population Surveillance; D015995:Prevalence; D014611:Vaccination; D014765:Viral Vaccines
chemical_list: D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral; D014765:Viral Vaccines