[The metabolic syndrome and its epidemiologic dimensions in historical perspective].
During the last five decades the metabolic syndrome has turned into an epidemic in countries with overnutrition and low levels of physical activity. About 15% of the population aged 40-75 in these countries exhibit exhibit the 'metabolic syndrome' cluster diseases. We define the metabolic syndrome as a cluster of diseases with at least three of the following components diagnosed in any one subject: ITG/type 2 diabetes, android obesity, dyslipidemia, hypertension, hyperuricemia, albuminuria and atherosclerosis. Insulin resistance was found in more than 80% of both the clinical type 2 diabetics and the subjects with IGT in the RIAD study. Intra-abdominal obesity and lipotoxicity are other important causes. Today the metabolic syndrome is--and for the near future will continue to be--the most important source of new diabetics, as well as a major cause of coronary heart disease.
Hanefeld
Markolf
M
Zentrum für Klinische Studien, Forschungsbereich Endokrinologie und Stoffwechsel, GWT, TU Dresden. hanefeld@gwt-tud.de
Köhler
Carsta
C
D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology; D018149:Glucose Intolerance / Q000150:complications / Q000453:epidemiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D024821:Metabolic Syndrome / Q000502:physiology*