[A case-control study on family history of Alzheimer's disease].
OBJECTIVE
To explore the relationship between Alzheimer's disease and its family history of the patients.


METHODS
Stratified analyses and logistic regression analysis were used to examine the association between Alzheimer's disease and its family history exposure in 127 cases and 254 matched controls from a population-based case-control study.


RESULTS
The risk of Alzheimer's disease was significantly higher in those who had at least one first-degree relative with dementia or major psychosis as compared to those who had no dementia or major relatives with psychosis (OR = 6.25; 8.33). Adjusted for age and level of education, family history of dementia was still associated with Alzheimer's disease positively (OR = 2.07).


CONCLUSIONS
This study provides evidence that familial aggregation of Alzheimer's disease might exist among people living Beijing.
Yao
Jiahong
J
Department of Epidemiology, Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China.
Li
Hui
H
Zhang
Zhenxin
Z
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003704:Dementia / Q000235:genetics; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000235:genetics