[Effects of glycyrrhetic acid on transmitter secretion].
The investigation of the effects of glycyrrhetic acid on spontaneous secretion of transmitter from neurotermination of the frog neuromuscular synapses showed that this substance, unlike glycyrrhizic acid, increased the frequency and amplitude of m. e. p. p. in a dose-dependent manner. The effect of glycyrrhetic acid is observed in calcium-free solution which may indicate ability of glycyrrhetic acid to mobilize calcium from inner cell pools. The effects of glycyrrhetic acid, in particular increasing the frequency of the m. e. p. p., testify that glycyrrhetic acid acts on the level of presynaptic membrane.
Ibodullaev
O N
ON
Institute of Physiology and Biophysics of the Uzbek Acad. Sci., Tashkent, 700095, 1 Niyazov St.
Asrarov
M I
MI
Kalikulov
D
D
Gagel'gans
A I
AI
Usmanov
P B
PB
D000818:Animals; D002118:Calcium / Q000378:metabolism; D006034:Glycyrrhetinic Acid / Q000494:pharmacology*; D019695:Glycyrrhizic Acid / Q000494:pharmacology; D008564:Membrane Potentials; D009045:Motor Endplate / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011896:Rana temporaria
D018377:Neurotransmitter Agents; D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid; D002118:Calcium