title: Immunochemical studies in Wilson's disease.
abstract: The present study deals with a total of 28 cases of Wilson's disease, 50 normal individuals alongwith siblings and parents of eight cases. Male predominance (18 out of 28 cases), a median age of 11 years and universal presence of Kayser-Fleischer (K. F.) ring marked the cardinal features. Furthermore, 11 patients had hepatic-neural presentation while two had only the K. F. Ring without clinical abnormality. Single Radial Immunodiffusion (SRID) as the absolute quantitative procedure revealed a profound deficiency of ceruloplasmin with the levels ranging anywhere between 0.5 mg/dI to 23 mg/dI amongst the patients of Wilson's disease. The data from siblings and parents also revealed deficiency in 15 out of 23 serum samples when subjected to disc electrophoresis-benzidine screening procedure.
authors.affiliation: Immunochemistry Section, Department of Microbiology, Government Medical College, Nagpur.
authors.forename: C
authors.initials: C
authors.lastname: Chande
authors.forename: Y S
authors.initials: YS
authors.lastname: Thakar
authors.forename: S
authors.initials: S
authors.lastname: Pande
authors.forename: A G
authors.initials: AG
authors.lastname: Dhanvijay
authors.forename: A M
authors.initials: AM
authors.lastname: Saoji
mesh_terms: D000293:Adolescent; D000328:Adult; D001797:Blood Protein Electrophoresis; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000172:deficiency*; D002648:Child; D002675:Child, Preschool; D004589:Electrophoresis, Disc; D005260:Female; D006527:Hepatolenticular Degeneration / Q000097:blood*; D006801:Humans; D005779:Immunodiffusion; D007223:Infant; D008297:Male
chemical_list: D002570:Ceruloplasmin