title: Toxicity studies of microbial insecticide Bacillus thuringiensis var. kenyae in rats, rabbits, and fish.
abstract: Bacillus thuringiensis var. kenyae (B.t.k.) is a microbial insecticide effective against lepidopteran pest species. Acute oral toxicity in rats and acute dermal toxicity, ocular irritation, skin irritation in rabbits were studied for the wettable powder formulation of B.t.k. In addition, toxicity of the wettable powder formulation was also studied in fresh water fish (Gambussia affinis). The results of these studies indicate that this wettable powder formulation of B.t.k. is nontoxic and nonirritant to rats, rabbits, and fish.
authors.affiliation: Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune, India.
authors.forename: S M
authors.initials: SM
authors.lastname: Meher
authors.forename: S L
authors.initials: SL
authors.lastname: Bodhankar
authors.lastname: Arunkumar
authors.forename: J N
authors.initials: JN
authors.lastname: Dhuley
authors.forename: D J
authors.initials: DJ
authors.lastname: Khodape
authors.forename: S R
authors.initials: SR
authors.lastname: Naik
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D001413:Bacillus thuringiensis; D001427:Bacterial Toxins / Q000008:administration & dosage / Q000633:toxicity*; D003532:Cyprinodontiformes; D005123:Eye / Q000187:drug effects; D005260:Female; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D007509:Irritants / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D010572:Pest Control, Biological; D011208:Powders; D011498:Protein Precursors / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects; D018675:Toxicity Tests
chemical_list: C029103:Bacillus thuringiensis protoxin; D001427:Bacterial Toxins; D007306:Insecticides; D007509:Irritants; D011208:Powders; D011498:Protein Precursors