Single-bead analysis in combinatorial chemistry.
Notable limitations have previously prevented the wide application of split synthesis. However, recent developments in highly condensed and miniaturized biological screening and single-bead analysis methods have argued for a revival of split combinatorial synthesis. Although there are still many challenges, we are now in a much better position to accomplish high-throughput analysis and screening of one-bead-one-compound libraries.
Yan
Bing
B
ChemRx Division of Discovery Partners International, 385 Oyster Point Boulevard, South San Francisco, CA 94080, USA. byan@chemrx.com
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D012116:Resins, Plant / Q000737:chemistry
D012116:Resins, Plant