[Human histocompatibility HLA system. Considerations in the light of current concepts. VIII. Polymorphism of HLA-related MIC system].
The recent advances about a new distinct family of polymorphic genes MIC (PERB11) "mapped" in the region of the major histocompatibility complex of antigens MHC were presented. Some aspects connected with their molecular organisation, degree of polymorphism, expression, and immunogenetical function were discussed. Special attention sacrificed to results of investigations over existence of particular MICA allele association with some diseases. Many relating problems, especially functional MICA and MICB genes are still in interests both clinicians, and immunogenetists.
Kedzierska
A
A
Samodzielna Pracownia, Immunologii Klinicznej Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
Turowski
G
G
D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008285:Major Histocompatibility Complex / Q000235:genetics*; D011110:Polymorphism, Genetic; D012641:Selection, Genetic; D013329:Structure-Activity Relationship
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A