Tissue and serum sialic acid levels in an animal head injury model.
BACKGROUND
Significant elevations of serum sialic acid level have been documented in various diseases including in a variety of central nervous system disorders. But, in head injury, there is no any study on the serum and brain tissue sialic acid levels. So, we planned an experimental study to evaluate serum and brain tissue sialic acid levels in head injury.


METHODS
Marmarou's impact-acceleration model was used in rats to produce diffuse brain injury. Rats were divided into equal three groups. In Group I, 450 g weight was fell from 1 m height to heads of subjects, and from 2 m in Group II. Group III was control group. Sialic acid levels were measured in both sera and brain tissue supernatants after trauma.


RESULTS
It was observed that serum sialic acid level was decreased according to the severity and period of trauma increased; and there was no change in brain tissue sialic acid levels.


CONCLUSIONS
Serum sialic acid level might be used as a marker to show the degree of diffuse brain injury.
Uslu
Ezel
E
Istanbul Universitesi, Cerrahpaşa Tip Fakültesi, Biyokimya Anabilim Dali.
Güzey
Feyza Karagöz
FK
Güzey
Deniz
D
Kucur
Mine
M
Belce
Ahmet
A
D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D008297:Male; D019158:N-Acetylneuraminic Acid / Q000097:blood / Q000378:metabolism*; D011237:Predictive Value of Tests; D051381:Rats; D017207:Rats, Sprague-Dawley; D015599:Trauma Severity Indices
D015415:Biomarkers; D019158:N-Acetylneuraminic Acid