Prognostic value of screening for irregular antibodies late in pregnancy in rhesus positive women.
BACKGROUND
To evaluate the prognostic value of screening for irregular antibodies late in pregnancy (third trimester) in rhesus positive women. Only those cases where irregular antibodies have not previously been demonstrated during routine screening in the first trimester with regard to clinically relevant complications in the newborn, were studied.


METHODS
All women living in Frederiksborg county and giving birth in 1996 (n = 4216) were assessed for inclusion in the study. This was done by gathering the files at the Hillerød and Hørsholm Hospitals' blood banks for antibody test results. Six hundred women were excluded because of the lack of either the rhesus type or the late antibody test.


RESULTS
Of the 3616 women, 3046 were rhesus positive, and 3012 of these had a negative first trimester screen test. Fifteen of the 3012 women later developed irregular antibodies in the third trimester, and were included in the study. This corresponds to only 0.5%, and none of these cases entailed perinatal complications for the mother or the child.


CONCLUSIONS
Routine screening of rhesus positive pregnant women in the third trimester is not rational from a cost-benefit perspective, if the only purpose is to prevent hemolytic disease of the newborn.
Andersen
Anita S
AS
Department of Obstetrics and Gynecology and Clinical Immunology, Hillerød Hospital, Denmark.
Praetorius
Lisbeth
L
Jørgensen
Henrik L
HL
Lylloff
Kirsten
K
Larsen
Kim T
KT
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D001788:Blood Grouping and Crossmatching / Q000379:methods*; D003718:Denmark / Q000453:epidemiology; D004899:Erythroblastosis, Fetal / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011237:Predictive Value of Tests; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis / Q000592:standards*; D012042:Registries; D012204:Rh-Hr Blood-Group System
D000906:Antibodies; D012204:Rh-Hr Blood-Group System