Cellular actions of Al at low (1.25 microM) concentrations in primary oligodendrocyte culture.
At a physiologically relevant concentration (1.25 microM), aluminum had an activating effect on oligodendrocyte cell cultures, similar to that previously reported for other cell types. G protein-linked signal transduction was stimulated as indicated by enhanced production of IP3, and protein synthesis was increased. At this concentration Al did not promote cell damage but did enhance oxidative effects initiated by reactive oxygen species. Both AlCl(3) and Al transferrin (AlTf) had similar actions at equimolar concentrations. In vivo, physiological Al ion may act by common cellular pathways in diverse cell types. These effects may be relevant to Al toxicological, pharmacological (immunoadjuvant), and physiological effects.
Golub
Mari S
MS
Department of Internal Medicine, University of California-Davis, 1 Shields Avenue, Davis, CA 95616, USA.
Zhang
Wei
W
Keen
Carl L
CL
Goldkorn
Tzipora
T
D000535:Aluminum / Q000494:pharmacology*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000494:pharmacology; D000818:Animals; D001059:Apoproteins / Q000494:pharmacology; D018929:Cell Culture Techniques; D002712:Chlorides / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D009836:Oligodendroglia / Q000187:drug effects* / Q000378:metabolism*; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D015290:Second Messenger Systems / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D014168:Transferrin / Q000494:pharmacology
D017607:Aluminum Compounds; D001059:Apoproteins; D002712:Chlorides; D019269:Phosphatidylinositol 4,5-Diphosphate; D017382:Reactive Oxygen Species; D014168:Transferrin; C066781:aluminum-transferrin; C028284:apotransferrin; D000077410:Aluminum Chloride; D000535:Aluminum