Growth of postoperative remnants of unilateral vestibular nerve schwannoma: role of the vestibular ganglion.
Histopathological examination of seven temporal bones from patients who underwent a removal of vestibular nerve schwannomas by the translabyrithine or middle fossa approaches has demonstrated small tumor remnants that failed to grow as long as 25 years after surgery. In spite of the high incidence of residual tumors, the clinical recurrence rate of tumors operated at our institution by the translabyrinthine or middle fossa approaches is low (0.3%). Immunohistochemical labeling of dividing cells demonstrated that segments of tumor adjacent to the vestibular nerve and ganglion contained more dividing cells than were present in areas of the tumor at a distance from them.
Linthicum
Fred H
FH
House Ear Institute, Los Angeles, Calif. 9057, USA. flinthicum@hei.org
Saleh
Emam S
ES
Hitselberger
William E
WE
Brackmann
Derald E
DE
Hung
Gene
G
D000368:Aged; D000369:Aged, 80 and over; D002455:Cell Division; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018365:Neoplasm, Residual; D009464:Neuroma, Acoustic / Q000276:immunology / Q000473:pathology* / Q000601:surgery*; D011184:Postoperative Period; D018809:Proliferating Cell Nuclear Antigen / Q000276:immunology; D013136:Spiral Ganglion / Q000276:immunology / Q000473:pathology* / Q000601:surgery*; D013701:Temporal Bone / Q000276:immunology / Q000473:pathology; D014725:Vestibular Nerve / Q000276:immunology / Q000473:pathology* / Q000601:surgery*
D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen