title: Direct L-proline-catalyzed asymmetric alpha-amination of ketones.
abstract: The first direct catalytic asymmetric alpha-amination of ketones catalyzed by l-proline has been developed. The reactions proceed with various azodicarboxylates as the nitrogen source in high yields and excellent enantioselectivities (up to 99% ee). The scope and potential of the reaction are demonstrated by further transformation of the alpha-hydrazino ketones formed to both optically active syn and anti-alpha-amino alcohol derivatives.
authors.affiliation: Center for Catalysis, Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark.
authors.forename: Nagaswamy
authors.initials: N
authors.lastname: Kumaragurubaran
authors.forename: Karsten
authors.initials: K
authors.lastname: Juhl
authors.forename: Wei
authors.initials: W
authors.lastname: Zhuang
authors.forename: Anders
authors.initials: A
authors.lastname: Bøgevig
authors.forename: Karl Anker
authors.initials: KA
authors.lastname: Jørgensen