title: [Synthesis of 1,4-dihydropyridines with blood pressure and blood-fat lowering effects].
abstract: To develop new drugs with the effects of lowering blood-fat and blood pressure, compounds 1-7 and 10 were synthesized by the reactions of 2-methyl-2-[4-(4-chlorobenzoyl)phenoxy]propionyl chloride with a hydroxyl group in 1,4-dihydropyridines. Compounds 8 and 9 were obtained by the reactions of 2-methyl-2-[4-(4-chlorobenzoyl)phenoxy]propionyl chloride with salicylic aldehyde first, and then with beta-aminocrotonates. All 1-10 are new compounds, and their structures were elucidated by means of 1HNMR and MS. The effects of compounds 1-10 on lowering cholesterol, triglyceride and blood pressure were investigated, and some of which were found to have the effects of lowering triglyceride and blood pressure.
authors.affiliation: Department of Pharmacy, Xijing Hospital.
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Zhao
authors.forename: Q
authors.initials: Q
authors.lastname: Mei
authors.forename: R
authors.initials: R
authors.lastname: Feng
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
chemical_list: D000959:Antihypertensive Agents; D004095:Dihydropyridines; D000960:Hypolipidemic Agents; D014280:Triglycerides; D002784:Cholesterol