Interleukin-1beta-induced increases of plasma catecholamine levels in rats: enhancement by superior cervical ganglionectomy.
In urethane-anesthetized rats, we examined the effect of bilateral superior cervical ganglionectomy on interleukin-1beta (IL-1beta)-induced elevation of plasma catecholamines. In sham-operated rats, intracerebroventricularly (i.c.v.) administered IL-1beta (100 ng/animal) effectively elevated plasma noradrenaline rather than plasma adrenaline. In superior cervical ganglionectomized rats, however, IL-1beta significantly elevated adrenaline to a greater extent than noradrenaline, and they were attenuated by i.c.v. administration of melatonin (100 ng/animal). Superior cervical ganglionectomy effectively reduced the plasma level of melatonin and urinary excretion of 6-sulfatoxymelatonin (a main urinary melatonin metabolite). These results suggest that superior cervical ganglia inhibit central sympatho-adrenomedullary outflow (especially adrenomedullary outflow) by increasing melatonin synthesis in the pineal gland of rats.
Wang
Munchun
M
Department of Pharmacology, Kochi Medical School, Kochi, Japan.
Murakami
Yoshinori
Y
Okada
Shoshiro
S
Yokotani
Kunihiko
K
D000818:Animals; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000097:blood*; D015171:Ganglionectomy; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology / Q000652:urine; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D017783:Superior Cervical Ganglion; D013997:Time Factors
D007375:Interleukin-1; C054513:6-sulfatoxymelatonin; D008550:Melatonin; D009638:Norepinephrine; D004837:Epinephrine