Synthesis and fasciolicidal activity of 5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole.
The synthesis and fasciolicidal activity of 5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole (6) is described. Compound 6 showed 100% activity in vitro at 146.70 and 29.34 microM concentrations. It also completely removed 3-d and 10-week-old Fasciola hepatica in sheep at a dose of 15 mg/kg.
Hernández-Campos
Alicia
A
Departamento de Farmacia, Facultad de Química, UNAM, CU, México D F, México.
Ibarra-Velarde
Froylán
F
Vera-Montenegro
Yolanda
Y
Rivera-Fernández
Norma
N
Castillo
Rafael
R
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis*; D001562:Benzimidazoles / Q000494:pharmacology; D003460:Crystallization; D005210:Fasciola hepatica / Q000187:drug effects*; D005211:Fascioliasis / Q000188:drug therapy / Q000469:parasitology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D012756:Sheep; D013329:Structure-Activity Relationship; D000077682:Triclabendazole
C468032:5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole; D000871:Anthelmintics; D001562:Benzimidazoles; D007093:Imidazoles; D007202:Indicators and Reagents; D009281:Naphthalenes; D000077682:Triclabendazole