Novel HLA-B alleles formed by an inter-locus recombination with HLA-C, HLA-B*0713 and B*6702.
This paper describes two novel HLA-B locus alleles. B*0713 appears to have resulted from an interlocus recombinational event which inserted a sequence from an HLA-C allele into B*0702. This event altered a significant portion of the alpha-1 domain alpha helix. B*6702 shares much of its exon 2 sequence with B*0713 but is identical in exon 3 to several HLA-B locus alleles including B*67012.
Steiner
N K
NK
Department of Oncology, Georgetown University Medical Center, Washington DC 20007, USA.
Baldassarre
L
L
Koester
R
R
Ng
J
J
Hartzman
R J
RJ
Hurley
Carolyn K
CK
D000483:Alleles; D001483:Base Sequence; D044383:Black People / Q000235:genetics; D003062:Codon / Q000032:analysis; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D015236:HLA-C Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
D003062:Codon; D015235:HLA-B Antigens; D015236:HLA-C Antigens