Expeditious syntheses of two carbohydrate-linked cisplatin analogs.
The syntheses of two carbohydrate-linked cisplatin analogs, namely lacto- and alpha-Gal-cisplatin, are described. A fusion enzymatic approach was used to create the diazido-alpha-Gal trisaccharide intermediate in the synthesis of alpha-Gal-cisplatin.
Chen
Yongsheng
Y
Department of Chemistry, Wayne State University, 373 Chemistry, Detroit, MI 48202, USA.
Janczuk
Adam
A
Chen
Xi
X
Wang
Jianqiang
J
Ksebati
Mohamad
M
Wang
Peng George
PG
D002240:Carbohydrate Sequence; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D005700:Galactosyltransferases / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D014534:UDPglucose 4-Epimerase / Q000378:metabolism
D011993:Recombinant Fusion Proteins; D005700:Galactosyltransferases; D014534:UDPglucose 4-Epimerase; C020551:galactose epimerase; D002945:Cisplatin