title: Dosimetric characteristics with spatial fractionation using electron grid therapy.
abstract: Recently, promising clinical results have been shown in the delivery of palliative treatments using megavoltage photon grid therapy. However, the use of megavoltage photon grid therapy is limited in the treatment of bulky superficial lesions where critical radiosensitive anatomical structures are present beyond tumor volumes. As a result, spatially fractionated electron grid therapy was investigated in this project. Dose distributions of 1.4-cm-thick cerrobend grid blocks were experimentally determined for electron beams ranging from 6 to 20 MeV. These blocks were designed and fabricated at out institution to fit into a 20 x 20-cm(2) electron cone of a commercially available linear accelerator. Beam profiles and percentage depth dose (PDD) curves were measured in Solid Water phantom material using radiographic film, LiF TLD, and ionometric techniques. Open-field PDD curves were compared with those of single holes grid with diameters of 1.5, 2.0, 2.5, 3.0, and 3.5 cm to find the optimum diameter. A 2.5-cm hole diameter was found to be the optimal size for all electron energies between 6 and 20 MeV. The results indicate peak-to-valley ratios decrease with depth and the largest ratio is found at Dmax. Also, the TLD measurements show that the dose under the blocked regions of the grid ranged from 9.7% to 39% of the dose beneath the grid holes, depending on the measurement location and beam energy.
authors.affiliation: University of Kentucky, Chandler Medical Center, Department of Radiation Medicine, Lexington 40536, USA. alimeig@pop.uky.edu
authors.forename: A S
authors.initials: AS
authors.lastname: Meigooni
authors.forename: S A
authors.initials: SA
authors.lastname: Parker
authors.forename: J
authors.initials: J
authors.lastname: Zheng
authors.forename: K J
authors.initials: KJ
authors.lastname: Kalbaugh
authors.forename: W F
authors.initials: WF
authors.lastname: Regine
authors.forename: M
authors.initials: M
authors.lastname: Mohiuddin
mesh_terms: D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D004583:Electrons / Q000627:therapeutic use*; D005240:Feasibility Studies; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods*