Relaxant effects of the essential oil of Ocimum gratissimum on isolated ileum of the guinea pig.
The effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) on guinea pig ileum were studied. EOOG (0.1-1000 microg/ml) reversibly and concentration-dependently relaxed the basal tone of the ileum and reversed the tonic contractions induced by 60 mM KCl and 10 microM acetylcholine, with IC(50) values of 23.8+/-5.2, 18.6+/-4.0 and 70.0+/-4.6 microg/ml, respectively. Our results show that EOOG exerts relaxant effects on intestinal smooth muscle, consistent with the popular use of the plant to treat gastrointestinal disorders.
Madeira
Socorro V F
SV
Departamento de Ciências Fisiológicas, Laboratório de Farmacologia dos Canais Iônicos, Centro de Ciências Saúde, Universidade Estadual do Ceará, Av. Paranjana 1700, Campus Itaperí, Fortaleza, CE 60740-000, Brazil.
Matos
Francisco José A
FJ
Leal-Cardoso
José H
JH
Criddle
David N
DN
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects* / Q000502:physiology*; D020128:Inhibitory Concentration 50; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects*; D009129:Muscle Tonus / Q000187:drug effects; D031339:Ocimum / Q000737:chemistry*; D009822:Oils, Volatile / Q000494:pharmacology*; D010276:Parasympatholytics / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology
D009822:Oils, Volatile; D010276:Parasympatholytics; D011189:Potassium Chloride; D000109:Acetylcholine