title: Prediction of allergenicity of gene-modified foods by serum-based testing.
abstract: On the basis of applying the IFBC/ILSI decision tree in a number of cases, a refinement of the scheme is suggested. Large differences in allergenic potential may be obtained by altering the route of administration of an allergen. Because an inhalation allergen can induce symptoms at different threshold doses depending on whether it is introduced via the inhalation or oral route, we propose that double-blind, placebo-controlled food challenges be performed in all cases of inhalation allergens being present in foods. Even proteins never previously ingested may cause IgE binding and elicit clinically relevant symptoms.
authors.affiliation: Laboratory of Medical Allergology, National University Hospital, DK-2100 Copenhagen, Denmark. lkpallgy@inet.uni2.dk
authors.forename: Lars K
authors.initials: LK
authors.lastname: Poulsen
mesh_terms: D000485:Allergens / Q000097:blood* / Q000276:immunology; D018556:Crops, Agricultural / Q000235:genetics*; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D010919:Placebos; D030821:Plants, Genetically Modified; D012307:Risk Factors
chemical_list: D000485:Allergens; D010919:Placebos; D007073:Immunoglobulin E