title: Coordinated transcription of key pathways in the mouse by the circadian clock.
abstract: In mammals, circadian control of physiology and behavior is driven by a master pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene expression profiling to identify cycling transcripts in the SCN and in the liver. Our analysis revealed approximately 650 cycling transcripts and showed that the majority of these were specific to either the SCN or the liver. Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components. Major processes regulated by the SCN and liver were found to be under circadian regulation. Importantly, rate-limiting steps in these various pathways were key sites of circadian control, highlighting the fundamental role that circadian clocks play in cellular and organismal physiology.
authors.affiliation: The Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
authors.forename: Satchidananda
authors.initials: S
authors.lastname: Panda
authors.forename: Marina P
authors.initials: MP
authors.lastname: Antoch
authors.forename: Brooke H
authors.initials: BH
authors.lastname: Miller
authors.forename: Andrew I
authors.initials: AI
authors.lastname: Su
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Schook
authors.forename: Marty
authors.initials: M
authors.lastname: Straume
authors.forename: Peter G
authors.initials: PG
authors.lastname: Schultz
authors.forename: Steve A
authors.initials: SA
authors.lastname: Kay
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Takahashi
authors.forename: John B
authors.initials: JB
authors.lastname: Hogenesch
mesh_terms: D000818:Animals; D001483:Base Sequence; D001683:Biological Clocks / Q000235:genetics / Q000502:physiology*; D056926:CLOCK Proteins; D002453:Cell Cycle / Q000502:physiology; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D020869:Gene Expression Profiling; D017403:In Situ Hybridization; D008099:Liver / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009154:Mutation; D013493:Suprachiasmatic Nucleus / Q000502:physiology; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D015534:Trans-Activators; D014157:Transcription Factors; D056926:CLOCK Proteins; C538944:Clock protein, mouse