Prognostic factors in non-small cell lung carcinoma.
This review aims in presenting the established and putative prognostic markers in non-small cell lung carcinoma (NSCLC). We have focused on the molecular/genetic alterations accompanying the pathogenesis of this malignancy, which may derange the cellular response to external and internal stimuli. A variety of factors influencing cell cycle progression, programmed cell death, drug resistance and immune evasion seem to obtain a predictive--though sometimes argued--role. Taking into account that a great number of these factors develope "cross-talking" protein-complex networks, their combined evaluation is likely to contribute towards a more accurate prediction of the clinical outcome in NSCLC patients.
Koutsami
Marilena K
MK
Department of Histology and Embryology, School of Medicine, University of Athens, Greece.
Gorgoulis
Vassilis G
VG
Kastrinakis
Nikolaos G
NG
Asimacopoulos
Panayiotis J
PJ
Kittas
Christos
C
D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D011379:Prognosis