Myeloid differentiation (MyD) primary response genes in hematopoiesis.
Myeloid Differentiation (MyD) primary response and Growth Arrest DNA-Damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45alpha MyD118/Gadd45beta, GADD45gamma, MyD116/Gadd34) genes, that have been cloned by virtue of there being co-ordinately induced upon the onset of terminal myeloid differentiation. This review delineates the role MyD genes play in blood cell development, where they function as positive regulators of terminal differentiation, lineage specific blood cell development and control of blood cell homeostasis, including growth inhibition and apoptosis.
Liebermann
Dan A
DA
Fels Institute for Cancer Research and Molecular Biology and the Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, PA 19140, USA. lieberma@unix.temple.edu
Hoffman
Barbara
B
D000818:Animals; D017209:Apoptosis; D001773:Blood Cells / Q000378:metabolism / Q000502:physiology; D002454:Cell Differentiation; D002455:Cell Division; D019070:Cell Lineage; D002470:Cell Survival; D006410:Hematopoiesis / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008954:Models, Biological; D022423:Myeloid Cells / Q000166:cytology*; D011506:Proteins / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction; D014158:Transcription, Genetic; D000097642:GADD45 Proteins
D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D000097642:GADD45 Proteins