[Study on the antidiuretic efficacy and mechanism of indapamide in central diabetes insipidus].
OBJECTIVE
To investigate the efficacy and antidiuretic mechanism of indapamide in central diabetes insipidus.


METHODS
We observed eight patients with central diabetes insipidus treated by indapamide (2.5-7.5 mg.d-1) or dihydro-chlorothiazide (50-70 mg.d-1) or carbamazepine (150-300 mg.d-1) for 8 days with randomized block design. The therapy was changed twice in sequence after 4 days without treatment. Urine output and indexes of water metabolism were also observed.


RESULTS
The urine output was reduced on the 4th day and 8th day with each therapy. The serum potassium and chloride concentration was decreased and renin activity was increased on the 4th and 8th day with indapamide therapy.


CONCLUSIONS
Indapamide has antidiuretic action on central diabetes insipidus. The action may result from the changes of hydroelectrolytes and renin-angiotensin-aldosterone system.
Peng
H
H
Institute of Metabolism & Endocrinology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Zhou
Z
Z
Zhao
W
W
Wu
H
H
D000293:Adolescent; D000328:Adult; D020790:Diabetes Insipidus, Neurogenic / Q000188:drug therapy*; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007190:Indapamide / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D004232:Diuretics; D007190:Indapamide