title: Dominant lethality and insect population control.
abstract: Recent advances in insect genetic engineering have opened up new possibilities in the genetic control of insect vectors of human diseases. We outline the current state of the sterile insect technique and show how the use of engineered dominant lethals can greatly increase the effectiveness of this approach. We consider alternative strategies based on the use of conditional dominant lethals that are not always active in the environment.
authors.affiliation: Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. luke.alphey@zoo.ox.ac.uk
authors.forename: Luke
authors.initials: L
authors.lastname: Alphey
authors.forename: Morten
authors.initials: M
authors.lastname: Andreasen
mesh_terms: D000818:Animals; D005260:Female; D005799:Genes, Dominant; D017344:Genes, Insect; D005804:Genes, Lethal; D005818:Genetic Engineering / Q000379:methods; D007303:Insect Vectors / Q000235:genetics; D007313:Insecta / Q000235:genetics*; D010572:Pest Control, Biological; D011156:Population Density