Plasma ProANP(1-30) reflects salt sensitivity in subjects with heredity for hypertension.
The aim of the present study was to investigate whether plasma concentration of proANP(1-30), the N-terminal fragment of the atrial natriuretic peptide prohormone, or 24-hour urinary excretion of urodilatin reflects the degree of salt sensitivity in hypertension-prone individuals. Plasma concentration of proANP(1-30) and urinary urodilatin excretion were determined at baseline, after 1 week on a low-salt diet (10 mmol/d) and after another week on a high-salt diet (240 mmol/d) in 30 healthy subjects with heredity for hypertension. Salt sensitivity was defined as the difference between mean arterial blood pressure after the high-salt diet and the mean arterial blood pressure after the low-salt diet. High- versus low-salt intake increased proANP(1-30) (668+/-330 versus 358+/-150 pmol/L; P<0.00001) and urodilatin (18.7+/-5.2 versus 16.0+/-8.3 pmol/24 h; P<0.05). ProANP(1-30) correlated with salt sensitivity at baseline (r=0.76, P<0.000001), after the low- (r=0.80, P<0.0000001) and high-salt diets (r=0.85, P<0.00000001). The increase in proANP(1-30) induced by changing from the low- to the high-salt diet was also directly related to salt sensitivity (r=0.78, P<0.000001). ProANP(1-30) was not related to urinary sodium excretion. Neither urodilatin nor the sodium-induced change in urodilatin correlated with salt sensitivity. However, urodilatin was related to the urinary sodium excretion at baseline (r=0.58, P<0.01) and after the high-salt diet (r=0.62, P<0.001). In conclusion, the close correlations between proANP(1-30) and salt sensitivity suggest that proANP(1-30) may serve as a marker for salt sensitivity and could be useful in identifying subjects who would benefit from dietary salt restriction to prevent development of hypertension.
Melander
Olle
O
Department of Endocrinology, Lund University, Malmö, Sweden. Olle.Melander@endo.mas.lu.se
Frandsen
Erik
E
Groop
Leif
L
Hulthén
U Lennart
UL
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000737:chemistry / Q000187:drug effects / Q000652:urine; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics / Q000652:urine; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood / Q000187:drug effects / Q000652:urine; D011498:Protein Precursors / Q000097:blood* / Q000737:chemistry / Q000187:drug effects; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*; D013223:Statistics as Topic
D010446:Peptide Fragments; D011498:Protein Precursors; D017673:Sodium Chloride, Dietary; C056452:Ularitide; D009320:Atrial Natriuretic Factor