[Genetic alterations of transcription cofactors in solid tumors].
Many hormones exert their effects through specific nuclear receptors which belong to a superfamily of ligand-activated transcription factors. These receptors control target gene expression through the recruitment of different cofactors acting as transcription activation or repression mediators, generally as parts of multiprotein complexes. The importance and the role in physiopathology of these different cofactors only begin to be defined. Different types of alterations affecting genes coding nuclear receptor transcription cofactors have indeed been described in cancer. The most important examples are gene amplification that leads to overexpression and gene mutations or translocations introducing qualitative modifications. This paper aims at bringing together the corresponding literature and focuses on gene alterations observed in solid tumors.
Rouayrenc
Jean-François
JF
Inserm U. 540, Endocrinologie moléculaire et cellulaire des cancers, 60, rue de Navacelles, 34090 Montpellier, France. v.cavailles@u540.montp.inserm.fr
Castet
Audrey
A
Rey
Jean-Marc
JM
Brouillet
Jean-Paul
JP
Pujol
Pascal
P
Vignon
Françoise
F
Maudelonde
Thierry
T
Cavaillès
Vincent
V
D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics; D002868:Chromosomal Proteins, Non-Histone; D002869:Chromosome Aberrations; D004265:DNA Helicases; D004268:DNA-Binding Proteins / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005784:Gene Amplification; D019398:Genes, BRCA1; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics; D056921:Nuclear Receptor Coactivator 3; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D000071796:SMARCB1 Protein; D009626:Terminology as Topic; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D004965:Estrogen Antagonists; D009687:Nuclear Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D056921:Nuclear Receptor Coactivator 3; C084108:SMARCA4 protein, human; D004265:DNA Helicases