Interactions of oxyphenbutazone with different cyclodextrins in aqueous medium and in the solid state.
The interactions between a nonsteroidal anti-inflammatory drugs, oxyphenbutazone (OPB), with two cyclodextrins, beta-cyclodextrin (beta-CD) and gamma-cyclodextrin (gamma-CD), have been studied in an aqueous medium and in the solid state. Differential scanning calorimetry, hot stage microscopy, thermogravimetric analysis and X-ray diffraction (XRD) powder have been the techniques used to characterize the interactions in the solid state. Although OPB forms inclusion compounds with beta- and gamma-CD in the aqueous medium, only the OPB/gamma-CD inclusion compound was obtained in the solid state by the kneading method. The XRD powder used at different temperatures has proven be a useful tool in characterizing the behaviour of these binary systems.
Veiga
M D
MD
Dpto. de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Madrid, Spain. mdveiga@eucmos.sim.ucm.es
Merino
M
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003505:Cyclodextrins / Q000737:chemistry*; D010113:Oxyphenbutazone / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003505:Cyclodextrins; D012996:Solutions; D010113:Oxyphenbutazone