Cyclin G: a regulator of the p53-Mdm2 network.
A recent study published in the April issue of Molecular Cell has shown that cyclin G, a p53 target, is a regulatory component of the active PP2A holoenzyme, which activates Mdm2 through dephosphorylation. These findings suggest that cyclin G is a key regulator of the p53-Mdm2 network.
Chen
Xinbin
X
Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D056746:Cyclin G; D056766:Cyclin G1; D016213:Cyclins / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D009687:Nuclear Proteins; D010749:Phosphoprotein Phosphatases / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D051736:Proto-Oncogene Proteins c-mdm2; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
C534703:Ccng1 protein, mouse; D056746:Cyclin G; D056766:Cyclin G1; D016213:Cyclins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; C497207:Mdm2 protein, mouse; D051736:Proto-Oncogene Proteins c-mdm2; D010749:Phosphoprotein Phosphatases