title: [Study on biocompatibility of skin reproductive membrane].
abstract: OBJECTIVE
  To study the biocompatibility of skin reproductive membrane.
  
  
  METHODS
  According to ISO's standards, the extractions of the skin reproductive membrane were prepared, and the acute systematic toxicity test, primary skin irritant test, cytotoxicity test, gene expression of type I collagen and fibronectin were detected to evaluate the biocompatibility of skin reproductive membrane.
  
  
  RESULTS
  All of those tests showed negative results.
  
  
  CONCLUSIONS
  The skin reproductive membrane has excellent biocompatibility in the level of the systematic, cellular and molecular biology.
authors.affiliation: Shanghai Biomaterials Research and Test Center, Shanghai the Second Medical University, Shanghai, P. R. China 200023.
authors.forename: L
authors.initials: L
authors.lastname: Ning
authors.forename: M
authors.initials: M
authors.lastname: Xue
authors.forename: H N
authors.initials: HN
authors.lastname: Huang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D024042:Collagen Type I / Q000096:biosynthesis* / Q000235:genetics; D005353:Fibronectins / Q000096:biosynthesis* / Q000235:genetics; D008567:Membranes, Artificial; D051379:Mice; D019736:Prostheses and Implants; D011897:Random Allocation; D012867:Skin; D012882:Skin Tests
chemical_list: D001672:Biocompatible Materials; D024042:Collagen Type I; D005353:Fibronectins; D008567:Membranes, Artificial