[Efficacy of baxtims in eliminating dysfunction of the liver monooxygenase system in exotoxinemia].
The hepatoprotector activity of baxtims was studied with respect to hepatobiliary system pathologies. The tetrachloromethane and bulldok induced liver damage is accompanied by a significant decrease in activity of the monooxygenase system, which leads to violation of the detoxicant function and protein synthesis function of liver, followed by the development of engenous intoxication. Baxtims produced a pronounced hepatoprotector effect in the case of liver damage induced by toxicants of various chemical nature. The drug favors an increase in the concentration of cytochromes in liver microsomes, a decrease in the level of medium-molecular-mass peptides, and normalization of the protein synthesis. This hepatoprotector action justifies the drug administration in cases of exotoxinemia.
Makhmudov
K A
KA
Vakhidov Scientific Research Center, ul. Farkhadskaya 10, Tashkent, 700115 Uzbekistan.
Gutnikova
A R
AR
Ablaeva
N Kh
NKh
Kasymov
A Kh
AKh
Misirov
Kh Kh
KhKh
Alimov
M M
MM
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology / Q000517:prevention & control*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D015786:Cytochromes b5 / Q000378:metabolism; D007306:Insecticides; D007455:Iodine / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D010105:Oxygenases / Q000378:metabolism*; D010938:Plant Oils / Q000627:therapeutic use; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D000074242:Sunflower Oil
D007306:Insecticides; D010938:Plant Oils; D020011:Protective Agents; D000074242:Sunflower Oil; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D007455:Iodine; D010105:Oxygenases