title: [Safety and tolerability of gabapentin].
abstract: OBJECTIVE
  To review the information available regarding the safety and tolerability of gabapentin (GBP) in the treatment of epilepsy.
  
  
  METHODS
  We reviewed the reports in the literature on the safety, adverse effects and tolerance of GBP as treatment, used as monotherapy or associated with other drugs, in epilepsies in patients of all age groups, including children, adults and the elderly.
  
  
  RESULTS
  All published studies confirm that GBP is a well tolerated drug when used for monotherapy or associated with other antiepileptic drugs. The commonest adverse effects seen were somnolence, fainting, ataxia, nystagmus, tremor and headache. However, their incidence was low and intensity mild. There was no clear relationship between the dose given and appearance of side effects, except for fainting and somnolence.
  
  
  CONCLUSIONS
  GBP is a drug which is free of unwanted side effects. Its safety and tolerability profile is excellent for treatment of simple and complex partial crises, with or without generalization in epileptic patients of all ages.
authors.affiliation: Unidad de Epilepsias. Departamento de Neurología y Neurocirugía; Clínica Universitaria de Navarra, Pamplona, 31008, España. cviteri@unav.es
authors.forename: C
authors.initials: C
authors.lastname: Viteri
mesh_terms: D000085:Acetates / Q000009:adverse effects / Q000627:therapeutic use*; D000588:Amines; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D003509:Cyclohexanecarboxylic Acids; D004361:Drug Tolerance; D004828:Epilepsies, Partial / Q000188:drug therapy*; D000077206:Gabapentin; D006801:Humans; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin