title: Intracranial lymphomas in simian retrovirus-positive Macaca fascicularis.
abstract: Two young adult Macaca fascicularis each had unilateral mydriasis and ptosis. Both animals were euthanatized, monkey No. I for progressive neurologic signs and monkey No. 2 because of a positive intradermal tuberculin test. At necropsy, each animal had a single intracranial mass on the ventral surface of the midbrain, surrounding the oculomotor nerve. Histologically, both masses were immunoblastic lymphomas. Immunohistochemical staining revealed the neoplasms to be of B-cell origin. Simian retrovirus (SRV) was isolated from both monkeys, but simian immunodeficiency virus was not found. Both animals lacked antibody to SRV. Both animals had antibodies to Epstein-Barr-like virus (EBV), but EBV antigens were not found by immunohistochemistry. Polymerase chain reaction analysis for integrated EBV DNA was unproductive. One of the animals (monkey No. 2) had a pulmonary infection with Mycobacterium avium, suggesting that immunosuppression was present. These cases represent a unique and previously undescribed type of solitary lymphoma in SRV-infected macaques.
authors.forename: Y A
authors.initials: YA
authors.lastname: Paramastri
authors.forename: J M
authors.initials: JM
authors.lastname: Wallace
authors.forename: K J
authors.initials: KJ
authors.lastname: Salleng
authors.forename: L M
authors.initials: LM
authors.lastname: Wilkinson
authors.forename: D E
authors.initials: DE
authors.lastname: Malarkey
authors.forename: J M
authors.initials: JM
authors.lastname: Cline
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary* / Q000821:virology; D007150:Immunohistochemistry / Q000662:veterinary; D008223:Lymphoma / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary* / Q000821:virology; D008252:Macaca fascicularis; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D008992:Monkey Diseases / Q000473:pathology* / Q000821:virology; D012192:Retroviridae Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D015301:Retroviruses, Simian / Q000302:isolation & purification*; D014412:Tumor Virus Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary*