Lack of pharmacokinetic interaction between the oral anti-influenza prodrug oseltamivir and aspirin.
Twelve volunteers completed a two-sequence, three-way crossover study of a single 900-mg aspirin dose and multiple doses of 75 mg of oseltamivir in the absence and presence of 900 mg of aspirin. The plasma and urine results demonstrated no pharmacokinetic interaction between oseltamivir and aspirin.
Oo
Charles
C
F. Hoffman-La Roche, Nutley, New Jersey 07110, USA. charles.oo@roche.com
Barrett
Joanne
J
Dorr
Albert
A
Liu
Baolian
B
Ward
Penelope
P
D000081:Acetamides / Q000493:pharmacokinetics* / Q000494:pharmacology*; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D001241:Aspirin / Q000493:pharmacokinetics* / Q000494:pharmacology*; D018592:Cross-Over Studies; D004347:Drug Interactions; D005260:Female; D006626:Hippurates / Q000097:blood / Q000652:urine; D006801:Humans; D008297:Male; D053139:Oseltamivir; D011355:Prodrugs / Q000493:pharmacokinetics* / Q000494:pharmacology*; D020156:Salicylic Acid / Q000097:blood / Q000652:urine
D000081:Acetamides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000998:Antiviral Agents; D006626:Hippurates; D011355:Prodrugs; D053139:Oseltamivir; C000693:salicylurate; D020156:Salicylic Acid; D001241:Aspirin