title: Impact of N-chlorotaurine on viability and production of secreted aspartyl proteinases of Candida spp.
abstract: N-Chlorotaurine, an endogenous long-lived oxidant, demonstrated fungicidal activity against Candida spp. and a postantifungal effect. Secreted aspartyl proteinases, important fungal virulence factors, proved to be a first target of impact. These results provide support for the topical application of N-chlorotaurine as an antimicrobial agent in yeast infections.
authors.affiliation: Institute of Hygiene and Social Medicine, Leopold-Franzens-University of Innsbruck, Innsbruck, Austria. m.nagl@uibk.ac.at
authors.forename: Markus
authors.initials: M
authors.lastname: Nagl
authors.forename: Andreas
authors.initials: A
authors.lastname: Gruber
authors.forename: Anita
authors.initials: A
authors.lastname: Fuchs
authors.forename: Claudia P
authors.initials: CP
authors.lastname: Lell
authors.forename: Eva-Maria
authors.initials: EM
authors.lastname: Lemberger
authors.forename: Margarete
authors.initials: M
authors.lastname: Borg-Von Zepelin
authors.forename: Reinhard
authors.initials: R
authors.lastname: Würzner
mesh_terms: D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D002175:Candida / Q000187:drug effects* / Q000201:enzymology* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D011480:Protease Inhibitors / Q000494:pharmacology*; D013654:Taurine / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D011480:Protease Inhibitors; D013654:Taurine; C043410:N-chlorotaurine; D016282:Aspartic Acid Endopeptidases