title: Validity of pulmonary function indices derived from the volumetric capnogram in horses with recurrent airway obstruction (RAO).
abstract: The objective of this study was to determine the accuracy with which pulmonary function indices derived from the volumetric capnogram can diagnose different degrees of recurrent airway obstruction (RAO) in 63 warmblood horses. The sensitivity, specificity, the area under the receiver operating curve (AUC), optimal cut-off values and predictive values of the indices were calculated. The results obtained have shown that there is no single index characterised by specificity and sensitivity to differentiate with an accuracy of >90 per cent between the different degrees of RAO compared to the clinical examination. The indices A(1)/A(2) and VD(alv)/ VT(alv) (AUC=0.55 and 0.53) appeared to have the highest relative sensitivity and specificity to differentiate between healthy horses and horses suffering from subclinical or minor RAO and the indices VD(phys)/ VT and VD(Bohr)/ VT between horses suffering from subclinical or minor RAO and horses with moderate to severe RAO (AUC=0.71 and 0.70). We do not consider it acceptable to use cut off values optimised for both maximal sensitivity and specificity, because a great number of horses would have been inappropriately classified.
authors.affiliation: Department of Equine Internal Medicine, Faculty of Veterinary Medicine, University of Berne, Switzerland. conny.herholz@knp.unibe.ch
authors.forename: C
authors.initials: C
authors.lastname: Herholz
authors.forename: R
authors.initials: R
authors.lastname: Straub
authors.forename: S
authors.initials: S
authors.lastname: Lüthi
authors.forename: Y
authors.initials: Y
authors.lastname: Moens
authors.forename: A
authors.initials: A
authors.lastname: Imhof
authors.forename: A
authors.initials: A
authors.lastname: Busato
mesh_terms: D000402:Airway Obstruction / Q000175:diagnosis* / Q000503:physiopathology*; D000818:Animals; D019296:Capnography / Q000662:veterinary*; D005260:Female; D006736:Horses / Q000502:physiology*; D008297:Male; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012129:Respiratory Function Tests / Q000379:methods*; D012680:Sensitivity and Specificity