A randomized trial of danazol pretreatment prior to endometrial resection.
OBJECTIVE
To assess the effect of danazol pretreatment in women undergoing endometrial resection for dysfunctional uterine bleeding.


METHODS
A total of 132 patients were randomly divided into danazol pretreated and untreated groups. Endometrial resection was carried out using a 24Fr cutting wire loop electrode and 1.5% glycine as the distension media. Patients were followed-up for 6 years. The t-test and Chi-square tests were used to test differences between the two groups.


RESULTS
The mean endometrial thickness, fluid used, fluid deficit, weight of resected tissue and duration of surgery were significantly greater in the unprepared group. Over 70% of patients in both the groups achieved amenorrhoea or spotting. Two (1.5%) patients underwent a repeat procedure and two (1.5%) others a hysterectomy, while the rest had hypomenorrhoea. The perimenstrual symptoms also showed significant improvement. No statistically significant difference was found in the outcomes of the two groups.


CONCLUSIONS
Endometrial resection is an effective alternative to hysterectomy and pretreatment of the endometrium is not necessary for good outcomes.
Kriplani
Alka
A
Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. kriplani@medinst.ernet.in
Manchanda
Ranjit
R
Nath
Jyoti
J
Takkar
Deep
D
D000328:Adult; D001706:Biopsy; D003613:Danazol / Q000627:therapeutic use*; D004714:Endometrial Hyperplasia / Q000473:pathology / Q000601:surgery; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000601:surgery; D004717:Endometrium / Q000473:pathology / Q000601:surgery*; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D015907:Hysteroscopy; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000601:surgery; D008595:Menorrhagia / Q000601:surgery; D017699:Pelvic Pain; D011127:Polyps / Q000473:pathology / Q000601:surgery; D011292:Premedication; D016896:Treatment Outcome; D014592:Uterine Hemorrhage / Q000601:surgery; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000473:pathology
D004965:Estrogen Antagonists; D003613:Danazol