title: [A case report of both CAF and docetaxel-resistant breast cancer responding to paclitaxel weekly therapy].
abstract: A 58-year-old woman underwent CAF and docetaxel therapy for lung, liver and bone metastases from breast cancer operated on 14 years ago. Because of progressive disease due to secondary resistance to CAF and docetaxel, the patient was given three courses of paclitaxel therapy (60 mg/m2, day 1, 8, 15, repeated every 4 weeks). The paclitaxel weekly therapy brought about no adverse effects and remarkable effects against lung and liver metastases (PR). Although the duration of the response to the paclitaxel therapy was limited to about two months due to the progression of skull bone metastasis, paclitaxel weekly therapy may be effective against both CAF and docetaxel-resistant breast cancer.
authors.affiliation: Dept. of Surgery, Osaka Rosai Hospital.
authors.forename: Takashi
authors.initials: T
authors.lastname: Emoto
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fujikawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Fujii
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: Eisaku
authors.initials: E
authors.lastname: Hamada
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Naka
authors.forename: Takamitu
authors.initials: T
authors.lastname: Komaki
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D001943:Breast Neoplasms / Q000473:pathology*; D003520:Cyclophosphamide / Q000494:pharmacology; D000077143:Docetaxel; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000494:pharmacology; D004334:Drug Administration Schedule; D019008:Drug Resistance, Neoplasm; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000494:pharmacology; D043823:Taxoids
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D004317:Doxorubicin; D003520:Cyclophosphamide; D017239:Paclitaxel; D005472:Fluorouracil