Microbial killing: oxidants, proteases and ions.
There is accumulating evidence that two aspects of the innate immune response, the respiratory burst and secretion of proteases, are intimately intertwined. A recent study suggests that K(+) may be the missing link. Is it time to merge signal transduction with biophysics?
Harrison
Rene E
RE
Cell Biology Programme, The Hospital for Sick Children Research Institute, 555 University Avenue, Ontario, M5G 1X8, Toronto, Canada.
Touret
Nicolas
N
Grinstein
Sergio
S
D000818:Animals; D010450:Endopeptidases / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D007477:Ions; D009504:Neutrophils / Q000166:cytology / Q000201:enzymology / Q000276:immunology* / Q000378:metabolism*; D016877:Oxidants / Q000378:metabolism*; D010588:Phagosomes / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D016897:Respiratory Burst
D007477:Ions; D016877:Oxidants; D010450:Endopeptidases; D011188:Potassium