High-speed combinatorial synthesis utilizing microwave irradiation.
Recent advances in microwave-assisted combinatorial chemistry include high-speed solid-phase and polymer-supported organic synthesis, rapid parallel synthesis of compound libraries, and library generation by automated sequential microwave irradiation. In addition, new instrumentation for high-throughput microwave-assisted synthesis continues to be developed at a steady pace. The impressive speed combined with the unmatched control over reaction parameters justifies the growing interest in this application of microwave heating.
Kappe
C Oliver
CO
Institute of Chemistry, Organic and Bioorganic Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010, Graz, Austria. oliver.kappe@uni-graz.at
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D008872:Microwaves; D011108:Polymers / Q000737:chemistry
D011108:Polymers