Cloning of a novel homeobox (NK-7.1) containing gene, DmHboxNK-7.1, from Drosophila melanogaster.
We have cloned a novel Drosophila melanogaster homeobox (Hbox) containing gene, NK-7.1 (Dm.HboxNK-7.1), which is located at 88B3 on the chromosome map, and is 1.5 kb downstream of the spn-B gene. The newly identified gene is expressed at high levels in the embryo, is switched off during larval and pupal stages, and is expressed again in the adult. The Hbox is highly similar to NK-1/S59 (Drosophila) and NK-3/bap (Drosophila). The amino acid (aa) identity ratios (%) were 58 between NK-7.1 and NK-1/S59, and between NK-7.1 and NK-3/bap. The other characteristic structures are the presence of homopolymeric aa stretches consisting of Q, N, and E.
Sakoyama
Yasuhiko
Y
Department of Genetics, Osaka University Medical School, Japan. sakoyama@genetic.med.osaka-u.ac.jp
Mizuta
Ikuko
I
Fukunaga
Akihiro
A
Michinomae
Masanobu
M
Smith
Phillip R
PR
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D018076:DNA, Complementary; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D005801:Genes, Homeobox; D017344:Genes, Insect; D018398:Homeodomain Proteins / Q000235:genetics*; D008969:Molecular Sequence Data
D018076:DNA, Complementary; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; C466199:NK7.1 protein, Drosophila