Antimutagenic mechanisms of Phyllanthus orbicularis when hydrogen peroxide is tested using Salmonella assay.
Phyllanthus orbicularis is a medicinal plant, endemic to Cuba, whose aqueous extract has proven antiviral properties and antimutagenic activities against aromatic amines and hydrogen peroxide. In addition, this plant extract presents antioxidant activity. In this paper, using the Salmonella assay with the experimental approaches of co-incubation, pre- and post-treatments, it is shown that the P. orbicularis extract protects bacterial cells from oxidative damage and mutation by some intracellular mechanism, irrespective of its antioxidant activity.
Ferrer
Mirle
M
Universitat Autònoma de Barcelona, Dpto de Genètica i de Microbiologia, Edifici C, 08193, Bellaterra, Barcelona, Spain.
Sánchez-Lamar
Angel
A
Luís Fuentes
Jorge
J
Barbé
Jordi
J
Llagostera
Montserrat
M
D016587:Antimutagenic Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006861:Hydrogen Peroxide; D009152:Mutagenicity Tests; D009153:Mutagens; D010100:Oxygen / Q000378:metabolism; D029803:Phyllanthus / Q000378:metabolism*; D010936:Plant Extracts / Q000627:therapeutic use*; D012475:Salmonella / Q000378:metabolism*; D013997:Time Factors
D016587:Antimutagenic Agents; D009153:Mutagens; D010936:Plant Extracts; D006861:Hydrogen Peroxide; D010100:Oxygen