title: Design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2- dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates.
abstract: [carbohydrate structure: see text] The design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates (13, 17) as DNA minor groove binding agents are described.
authors.affiliation: Department of Chemistry, University of Alberta, Edmonton, AB, Canada T6G 2G2.
authors.forename: Rohtash
authors.initials: R
authors.lastname: Kumar
authors.forename: J William
authors.initials: JW
authors.lastname: Lown
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis*; D001547:Benzaldehydes / Q000737:chemistry; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D007211:Indoles / Q000737:chemistry*; D007700:Kinetics; D051379:Mice; D011758:Pyrroles / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000447:Aldehydes; D018906:Antineoplastic Agents, Alkylating; D001547:Benzaldehydes; D007202:Indicators and Reagents; D007211:Indoles; D011758:Pyrroles; C458299:bis-1-chloromethyl-5-hydroxy-1,2- dihydro-3H-benz(e)indole(seco-CBI)-pyrrole polyamide; C044736:phenylacetylene; D000114:Acetylene