Comparisons of carboplatin and cisplatin as potentiators of 5-fluorouracil and radiotherapy in the mouse L1210 leukaemia model.
BACKGROUND
Carboplatin (CBDCA), an analogue of cisplatin (CDDP), has synergistic antitumour activity in combination with 5-fluorouracil (5-FU) and radiotherapy and is better tolerated than CDDP by patients. In an in vivo model, we evaluated the doses of CBDCA and CDDP required to obtain, in these combinations, equal curative effects.


METHODS
Groups of 6-week-old B6D2F1 mice were injected with L1210 leukaemia. The chemotherapy was administered 24 hours after L1210 inoculation, while the radiotherapy was performed 1 or 24 hours later. Treatment results were evaluated in terms of prolonged survival.


RESULTS
The same degree of potentiation was obtained at the dose ratio CBDCA/CDDP of 4 in association with 5-FU and 3 in combination 5-FU/radiotherapy, with a longer delay between CBDCA administration and radiotherapy.


CONCLUSIONS
CBDCA could be used as a potentiator of 5-FU and radiosensitizer at a daily dose of 20 mg/m2 in clinical therapy.
Dionet
Claude A
CA
Département de Radiothérapie, Centre Jean Perrin I, Clermont-Ferrand, France.
Rapp
Maryse
M
Tchirkov
Andreï
A
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D016190:Carboplatin / Q000008:administration & dosage / Q000494:pharmacology*; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D003131:Combined Modality Therapy; D004357:Drug Synergism; D005472:Fluorouracil / Q000008:administration & dosage; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000532:radiotherapy*; D008297:Male; D051379:Mice
D016190:Carboplatin; D002945:Cisplatin; D005472:Fluorouracil