title: Levels of soluble E-selectin and ICAM-1 in the coronary circulation of patients with stable coronary artery disease: association with the severity of coronary atherosclerosis.
abstract: The recruitment of circulating leukocytes to atherosclerotic sites is mediated by a family of adhesion molecules. The objective of the present study was to evaluate the relationship between circulating adhesion molecule levels in the coronary circulation and the severity of coronary atherosclerosis in patients with stable coronary artery disease. The subjects were 79 patients undergoing coronary angiography. According to the severity of coronary atherosclerosis as assessed by the Gensini Score (GS) of the left coronary artery, they were classified into three groups: group C (no organic stenosis, score 0, n = 14), group M (mild organic stenosis, score 1-13, n = 39) and group S (severe organic stenosis, score > or = 14, n = 26). Blood samples were taken from the aorta (Ao) and coronary sinus (CS), and plasma levels of soluble E-selectin (sE-selectin) and soluble intercellular adhesion molecule-1 (sICAM-1) were measured by enzyme-linked immunosorbent assay. These levels were then compared between groups. There were no significant differences in plasma sICAM-1 levels in the Ao or CS between the three groups. The difference in sICAM-1 levels between the CS and Ao (CS-Ao) also showed no significant difference. Plasma sE-selectin levels in both the Ao and CS were significantly higher in group S than in groups C and M (p < 0.05), but there were no significant differences in CS-Ao. There was a weak but significant correlation between the plasma levels of these adhesion molecules and the number of coronary risk factors present. Multivariate analysis showed that the number of coronary risk factors was the only positive predictor (p = 0.0048) of the GS; there was no association between the plasma level of either adhesion molecule and the GS. In patients with stable coronary artery disease, sICAM-1 plasma levels do not indicate the severity of coronary atherosclerosis, while sE-selectin plasma levels appear to reflect the severity of systemic rather than coronary atherosclerosis.
authors.affiliation: First Department of Internal Medicine, Niigata University Medical Hospital, Japan.
authors.forename: Akimitsu
authors.initials: A
authors.lastname: Nasuno
authors.forename: Taku
authors.initials: T
authors.lastname: Matsubara
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Hori
authors.forename: Kotaro
authors.initials: K
authors.lastname: Higuchi
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Imai
authors.forename: Iwao
authors.initials: I
authors.lastname: Nakagawa
authors.forename: Keiichi
authors.initials: K
authors.lastname: Tsuchida
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Ozaki
authors.forename: Tohru
authors.initials: T
authors.lastname: Mezaki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Ichiro
authors.initials: I
authors.lastname: Fuse
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Aizawa
mesh_terms: D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis; D003326:Coronary Circulation; D003327:Coronary Disease / Q000097:blood* / Q000503:physiopathology; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012720:Severity of Illness Index
chemical_list: D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1