D2-lymphadenectomy improves the survival of patients with peritoneal cytology-positive gastric cancer.
BACKGROUND
According to the current Japanese Classification of Gastric Cancer, patients with peritoneal cytology-positive (CY1) gastric cancer are classified as stage IV and the curative potential of resection for these patients is regarded as non-curative.


METHODS
We compared the clinical outcome of CY1 patients (n=55) with those of patients with other non-curative factors (n=87), to clarify the optimal surgical strategy for CY1 patients.


RESULTS
The 5-year survival rate of CY1 patients was 10.8%, which was significantly better than that observed in the patients with the other non-curative factors. Among CY1 cases, survival outcome of the patients with lymph node metastasis limited to within group 2 was significantly better than the patients with group 3 lymph node metastasis.


CONCLUSIONS
These results suggested that gastrectomy combined with extended lymphadenectomy should be recommended for patients with gastric cancer who have positive peritoneal cytology as the only non-curative factor.
Inada
Takao
T
Department of Surgery, Tochigi Cancer Center, Utsunomiya, Japan. tinada@tcc.pref.tochigi.jp
Ogata
Yoshiro
Y
Kubota
Tetsuro
T
Ishihara
Masami
M
Tomikawa
Moriaki
M
Ando
Jiro
J
Ozawa
Iwao
I
Hishinuma
Shoichi
S
Shimizu
Hideaki
H
Kotake
Kenjiro
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010529:Peritoneal Cavity / Q000473:pathology*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome