[Experimental study on application of allogeneic bone matrix gelatin in the intervertebral fusion].
OBJECTIVE
To testify the inductive osteogenesis of allogeneic bone matrix gelatin (BMG) in promoting intervertebral fusion.


METHODS
The gelatin sponge, allogeneic BMG, decalcified bone matrix (DBM) and alcohol conserved bone were implanted respectively into the intervertebral space of rabbit, whose intervertebral discs were removed before implantation. The intervertebral spaces were evaluated by X-ray and histological examination at 4, 8, and 12 weeks after operation.


RESULTS
No obvious immune rejection was observed. Amounts of new bone were formed in the intervertebral spaces at 4 and 8 weeks. And complete infusion of the intervertebral spaces were appeared at 12 weeks.


CONCLUSIONS
Allogeneic BMG can promote bone fusion of intervertebral spaces through osteoinduction, which suggests that allogeneic BMP is an ideal substitute for bone replacement.
Bai
L H
LH
Department of Orthopedic Surgery, Second Clinical Medical College, China Medical University, Shenyang Liaonin, P. R. China 110003.
Zhang
Y Q
YQ
Wang
H Y
HY
D000818:Animals; D001857:Bone Matrix / Q000637:transplantation*; D018786:Bone Substitutes; D005780:Gelatin; D008159:Lumbar Vertebrae / Q000601:surgery; D010012:Osteogenesis; D019736:Prostheses and Implants; D011817:Rabbits; D011897:Random Allocation; D013123:Spinal Fusion / Q000379:methods*
D018786:Bone Substitutes; D005780:Gelatin