Maternal thyrotoxicosis causing central hypothyroidism in infants.
We describe three infants born to mothers with poorly controlled Graves' disease, who developed transient central hypothyroidism in the immediate postnatal period. Suppression of the fetal pituitary-thyroid axis may be due to placental transfer of thyroxine from the hyperthyroid mother. This may persist for months postnatally, necessitating treatment to optimise neurodevelopmental outcome.
Lee
Y S
YS
Department of Paediatrics, National University Hospital, Singapore. paeleeys@nus.edu.sg
Loke
K Y
KY
Ng
S C Y
SC
Joseph
R
R
D000328:Adult; D003409:Congenital Hypothyroidism; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000517:prevention & control; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis / Q000209:etiology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications; D012846:Singapore