Spatial dynamics of receptive fields in cat primary visual cortex related to the temporal structure of thalamocortical feedforward activity. Experiments and models.
We investigated how changes in the temporal firing rate of thalamocortical activity affect the spatiotemporal structure of receptive field (RF) subunits in cat primary visual cortex. Spike activity of 67 neurons (48 simple, 19 complex cells) was extracellulary recorded from area 17/18 of anesthetized and paralyzed cats. A total of 107 subfields (on/off) were mapped by applying a reverse correlation technique to the activity elicited by bright and dark rectangles flashed for 300 ms in a 20x10 grid. We found that the width of the (suprathreshold) discharge fields shrank on average by 22% during this 300-ms-long stimulus presentation time. Fifty-eight subfields (54%) shrank by more than 20% of peak width and only ten (less than 10%) showed a slight increase over time. The main size reduction took place 40-60 ms after response onset, which corresponded to the transition from transient peak firing to tonic visual activity in thalamocortical relay cells (TC). The experimentally obtained RFs were then fitted with the aid of a neural field model of the primary visual pathway. Assuming a Gaussian-shaped spatial sensitivity profile across the RF subfield width, the model allowed us to estimate the subthreshold RF (depolarization field, D-field) from the minimal discharge field (MDF). The model allowed us to test to what degree the temporal dynamics of thalamocortical activity contributes to the spatiotemporal changes of cortical RFs. To this end, we performed the fitting procedure either with a pure feedforward model or with a field model that also included intracortical feedback. Spatial and temporal parameters obtained from fits of the experimental RFs matched closely to those achieved by simulating a pure feedforward system with the field model but were not compatible with additional intracortical feedback. Thus, our results show that dot stimulation, which optimally excites thalamocortical cells, leads to a shrinkage with respect to the size of the RF subfield at the first transient response of visual cortical RFs which seems mainly due to a change in the thalamic firing pattern. In these experiments little or no influence from intracortical sources was observed, which, however, may play a role when using more complex visual stimuli.
Suder
Katrin
K
Institute of Physiology, Department of Neurophysiology, Ruhr University, Bochum, Germany.
Funke
Klaus
K
Zhao
Yongqiang
Y
Kerscher
Nicolas
N
Wennekers
Thomas
T
Wörgötter
Florentin
F
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002415:Cats; D005246:Feedback / Q000502:physiology*; D005829:Geniculate Bodies / Q000166:cytology / Q000502:physiology; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology; D017711:Nonlinear Dynamics; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology; D013788:Thalamus / Q000166:cytology / Q000502:physiology*; D013997:Time Factors; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology*; D014795:Visual Pathways / Q000166:cytology / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*