Enhanced radical-scavenging activity of a planar catechin analogue.
A catechin analogue in which the geometry was constrained to be planar was synthesized. The planar catechin showed excellent radical-scavenging ability, comparable to that of quercetin, and efficient protection against DNA strand breakage induced by the Fenton reaction.
Fukuhara
Kiyoshi
K
Division of Organic Chemistry, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501, Japan. fukuhara@nihs.go.jp
Nakanishi
Ikuo
I
Kansui
Hisao
H
Sugiyama
Etsuko
E
Kimura
Mitsuhiro
M
Shimada
Tomokazu
T
Urano
Shiro
S
Yamaguchi
Kentaro
K
Miyata
Naoki
N
D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004249:DNA Damage; D004278:DNA, Superhelical / Q000737:chemistry / Q000187:drug effects; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000737:chemistry; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000975:Antioxidants; D004278:DNA, Superhelical; D016166:Free Radical Scavengers; D017665:Hydroxyl Radical; D002392:Catechin; D011794:Quercetin