Reducing mortality in Salmonella enterica serovar Typhimurium-infected mice with a tripeptidic serum fraction.
Salmonellosis-induced mortality in female Swiss Webster mice decreased significantly when tripeptidic immunostimulant (TPI) was administered prophylactically. Prophylactic benefits developed in a dose-dependent manner wherein 15 mg of TPI given 1 day before challenge reduced mortality by 70%.
Parker
Todd A
TA
Department of Biochemistry and Molecular Biology, Mississippi State University, Mississippi State, Mississippi 39762, USA.
Willeford
Kenneth O
KO
Parker
Suzanne
S
Buddington
Karyl
K
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006041:Goats / Q000502:physiology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000382:microbiology; D051379:Mice; D009842:Oligopeptides / Q000097:blood / Q000494:pharmacology*; D012480:Salmonella Infections / Q000188:drug therapy* / Q000401:mortality; D019779:Salmonella enterica; D016019:Survival Analysis; D013997:Time Factors
D000276:Adjuvants, Immunologic; D008070:Lipopolysaccharides; D009842:Oligopeptides