14'-Hydroxymytoxin B and 16-hydroxyroridin E, two new cytotoxic trichothecenes from Myrothecium roridum.
Two new trichothecenes, 14'-hydroxymytoxin B (1) and 16-hydroxyroridin E (3), were isolated from a fermentation extract of Myrothecium roridum. The structures of 1 and 3 were determined by spectral data interpretation. Both compounds showed potent cytotoxic activity against primary soft-tissue sarcoma cells.
Alvi
Khisal A
KA
Albany Molecular Research Inc., Bothell Research Center, 18804 North Creek Parkway, Bothell, Washington 98011-8012, USA. khisal.alvi@albmolecular.com
Rabenstein
John
J
Woodard
Jon
J
Baker
Dwight D
DD
Bergthold
Jennifer D
JD
Lynch
John
J
Lieu
Kuo L
KL
Braude
Irwin A
IA
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001900:Boston; D002478:Cells, Cultured / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012509:Sarcoma; D014255:Trichothecenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
C460126:14'-hydroxymytoxin B; C460127:16-hydroxyroridin E; D000970:Antineoplastic Agents; D014255:Trichothecenes