Monoclonal antibodies against human placental sphingomyelinase.
Monoclonal antibodies against human placental acid sphingomyelinase have been raised. The antibodies are all of the IgG1 type, and are quite specific for the enzyme. One of the antibodies has been used to demonstrate a common antigenic identity of three polypeptides (mol.wts. 90,000, 72,000, and 48,000) of a purified sphingomyelinase preparation.
Freeman
S J
SJ
Division of Neurosciences, The Hospital for Sick Children, Toronto, Ontario, Canada.
Davidson
D J
DJ
Shankaran
P
P
Callahan
J W
JW
D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000276:immunology*; D005260:Female; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood; D008970:Molecular Weight; D010455:Peptides / Q000276:immunology; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D013108:Sphingomyelin Phosphodiesterase / Q000276:immunology* / Q000302:isolation & purification
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D010455:Peptides; D013108:Sphingomyelin Phosphodiesterase