[The preparation and bioactivities of chiral analogs of baogongteng A].
Eight chiral analogs of baogongteng A were prepared from (+/-)-3 alpha-hydroxy-6 beta-acetoxytropane by chemical resolution. In myotic or mydriatic tests in rabbits, (-)-3 alpha-paramethyl benzenesulfonyloxy-6 beta-acetoxytropane showed cholinergic activities, while (+)-3 alpha-benzoyloxy-6 beta-acetoxytropane and (+)-3 alpha-parachloro benzoyloxy-6 beta-acetoxytropane showed anticholinergic activities.
Yang
L
L
Department of Chemistry, Shanghai Second Medical University, Shanghai 200025.
Wang
H
H
D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008916:Miotics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008968:Molecular Conformation; D011817:Rabbits; D013329:Structure-Activity Relationship; D014326:Tropanes
D019086:Bridged Bicyclo Compounds, Heterocyclic; D018680:Cholinergic Antagonists; D004365:Drugs, Chinese Herbal; D008916:Miotics; D014326:Tropanes; C027863:bao gong teng A