Prevalence of ICA-12 and other autoantibodies in north Indian patients with early-onset diabetes.
This study attempts to assess the prevalence of various autoantibodies in early-onset diabetics in northern India, with emphasis on antibodies against glutamic acid decarboxylase (GAD65), IA-2, ICA-12, 21-hydroxylase (21-OH), and tissue transglutaminase (TTG). GAD65 and IA-2 antibodies were found to be present in approximately 26% of cases of type 1 diabetes. A subset of patients clinically diagnosed to have MMDM appears to have an autoimmune etiology, with more than 20% showing serpositivity for IA-2 antibodies. Antibodies against ICA-12 were prevalent in both type 1 diabetes and MMDM. Approximately one of seven patients with type 1 diabetes showed erological evidence of celiac disease.
Tandon
N
N
Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India.
Shtauvere-Brameus
A
A
Hagopian
W A
WA
Sanjeevi
C B
CB
D017668:Age of Onset; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001324:Autoantigens / Q000097:blood / Q000276:immunology*; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D005260:Female; D006609:High Mobility Group Proteins / Q000097:blood / Q000276:immunology*; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D055755:SOXD Transcription Factors
D001323:Autoantibodies; D001324:Autoantigens; D006609:High Mobility Group Proteins; C491720:SOX13 protein, human; D055755:SOXD Transcription Factors