title: [Plerosis of cDNA array of normal human nasopharyngeal tissue and nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To compare gene expression gene profile of nasopharyngeal carcinoma (NPC) tissue with that of normal nasopharyngeal tissues by cDNA array and to discuss possible functions of DNA repair-related genes in NPC tissue.
  
  
  METHODS
  After hybridization of atlas human cancer cDNA expression array 7742 - 1, atlas hybridization results were analyzed by Atlas Image 1.01 a software package. Using RT-PCR was used to confirm the results.
  
  
  RESULTS
  Of 63 differentially expressed genes in quadrangle C including DNA damage response, repair & recombination-related genes, 6 DNA repair-related genes were up-regulated, 12 were down-regulated.
  
  
  CONCLUSIONS
  DNA repair-related genes may be involved in patho-physiological process of nasopharyngeal carcinoma.
authors.affiliation: Laboratory of Cancerous Change and Invasion, Xiangya Medical College, Central South University, Changsha 410078, China.
authors.forename: Weinong
authors.initials: W
authors.lastname: Han
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Lu
authors.initials: L
authors.lastname: Xie
authors.forename: Liangguo
authors.initials: L
authors.lastname: Xu
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Kaitai
authors.initials: K
authors.lastname: Yao
mesh_terms: D004260:DNA Repair / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D009305:Nasopharynx / Q000378:metabolism* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012334:RNA, Neoplasm / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D012334:RNA, Neoplasm