Micronuclei induced by sulfur dioxide inhalation in mouse bone-marrow cells in vivo.
Induction effects of sulfur dioxide (SO2) inhalation on micronuclei (MN) formation in the polychromatic erythrocytes (PCE) of mouse bone marrow were studied in vivo. It was shown that SO2 inhalation caused an increase of MN frequencies in the PCE cells in a dose-dependent manner. These results from male and female mice were very similar; no sex difference was observed. These results imply that SO2 is a clastogenic and genotoxic agent.
Meng
Ziqiang
Z
Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan, People's Republic of China. zqmeng@sxu.edu.cn
Zhang
Bo
B
Ruan
Aidong
A
Sang
Nan
N
Zhang
Jianbiao
J
D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000473:pathology; D002869:Chromosome Aberrations / Q000139:chemically induced*; D005260:Female; D019570:Inhalation Exposure; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D013458:Sulfur Dioxide / Q000008:administration & dosage / Q000633:toxicity*
D000393:Air Pollutants; D013458:Sulfur Dioxide