A case of cutaneous delayed-type allergy to oral dexamethasone and to betamethasone.
Corticosteroids are drugs that may cause allergic contact dermatitis, but systemic allergic reactions to these drugs are rare. A 29-year-old man developed a maculopapular rash during an oral therapy with betamethasone. Patch tests demonstrated a delayed-type allergy to dexamethasone, betamethasone and fluocortolone. Oral, intramuscular or topical provocation tests with other corticosteroids - deflazacort, hydrocortisone, methylprednisolone, fluticasone dipropionate, triamcinolone and prednisone - were all negative. This demonstrates that a patient with a systemic allergy to a group of corticosteroids can tolerate those of other groups.
Nucera
Eleonora
E
Department of Allergology, Policlinico 'A. Gemelli', Università Cattolica del Sacro Cuore, Roma, Italia.
Buonomo
Alessandro
A
Pollastrini
Emanuela
E
De Pasquale
Tiziana
T
Del Ninno
Massimiliona
M
Roncallo
Chiara
C
Schiavino
Domenico
D
Patriarca
Giampiero
G
D000284:Administration, Oral; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects; D001623:Betamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D004342:Drug Hypersensitivity; D005500:Follow-Up Studies; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D008297:Male; D010035:Otitis Media, Suppurative / Q000188:drug therapy; D010328:Patch Tests; D018570:Risk Assessment
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D001623:Betamethasone