title: Fc gamma receptor genes as risk markers for localized aggressive periodontitis in African-Americans.
abstract: BACKGROUND
  Receptors for the Fc fragment of immunoglobulin G (Fc gammaRs) play a crucial role in host defense against bacterial infection by linking humoral and cell-mediated immune responses. Allelic variants of certain Fc gammaRs have been shown to differ relative to their biologic activity. Thus, genes encoding allotypes with diminished activity have been suggested as potential risk factors for infectious diseases. The goal of this study was to determine whether specific Fc gammaRIIa, Fc gammaRIIIa, and Fc gammaRIIIb alleles and/or genotypes could be used to predict susceptibility to localized aggressive periodontitis (LAgP) in an African-American population.
  
  
  METHODS
  Whole blood or saliva was obtained from 48 LAgP and 67 periodontally-healthy African-American subjects. DNA was prepared from each sample. Fc gammaRIIa and Fc gammaRIIIa genotyping was analyzed by polymerase chain reaction (PCR) amplification of DNA with allele-specific primers followed by allele-specific restriction digestion of the products. Fc gammaRIIIb genotyping was done by allele-specific PCR.
  
  
  RESULTS
  There was a statistically significant over-representation of the Fc gammaRIIIb-NA2 allele in LAgP patients compared to controls (P = 0.024). Relative to the Fc gammaRIIIb-NA1/NA2 and homozygous NA1/NA1 genotypes, the prevalence of the Fc gammaRIIIb NA2/NA2 genotype was higher in the LAgP group relative to the control population. Individuals expressing this genotype appeared at greater risk for developing LAgP (odds ratio 2.271, 95% confidence interval: 1.005 to 5.132). There were no significant differences in the distribution of the Fc gammaRIIa H/R or Fc gammaRIIIa-158 F/V genotypes nor their allelic frequencies between the LAgP patients and controls.
  
  
  CONCLUSIONS
  These data suggest that the Fc gammaRIIIb NA2 allele and/or NA2/NA2 genotype may represent risk markers for susceptibility to LAgP in African-Americans.
authors.affiliation: Dental Research Center, University of Medicine and Dentistry of New Jersey, Newark, USA.
authors.forename: Yali
authors.initials: Y
authors.lastname: Fu
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Korostoff
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Fine
authors.forename: Mark E
authors.initials: ME
authors.lastname: Wilson
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D000483:Alleles; D015703:Antigens, CD / Q000235:genetics; D044383:Black People / Q000235:genetics*; D016009:Chi-Square Distribution; D002648:Child; D016001:Confidence Intervals; D005260:Female; D058851:GPI-Linked Proteins; D005787:Gene Frequency; D005803:Genes, Immunoglobulin / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006720:Homozygote; D006801:Humans; D007519:Isoantigens / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D016017:Odds Ratio; D010518:Periodontitis / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*; D012307:Risk Factors; D013223:Statistics as Topic
chemical_list: D015703:Antigens, CD; C428200:FCGR3B protein, human; C080568:Fc gamma receptor IIA; D058851:GPI-Linked Proteins; D005819:Genetic Markers; D007519:Isoantigens; D017452:Receptors, IgG; C067704:neutrophil-specific antigen NA1, human; C072753:neutrophil-specific antigen NA2