[Diagnosis of pulmonary lesions in acute respiratory insufficiency in patients with depressed hemopoiesis].
OBJECTIVE
To analyse causes of acute respiratory failure (ARF) and methods of diagnosis of pulmonary lesions in patients with depressed hemopoiesis (DH).


METHODS
50 patients with DH and ARF were examined according to the protocol including x-ray, computed tomography, fibrobronchoscopy with bronchoalveolar lavage, cytological, bacteriological, virusological studies of the lavage fluid, biopsy of the lung. The algorithm of the protocol is provided.


RESULTS
Sensitivity of the lavage fluid in diagnosis of fungal, bacterial, pneumocystic and cytomegaloviral infections was 84, 78, 93 and 93%, respectively. The cytologic examination of the lavage fluid may detect lung infiltration with blood tumors. In complicated diagnostic cases lung biopsy verified pulmonary lesion but its conduction aggravated the patients' condition. ARF patients with DH, bacterial flora, fungi, cytomegalovirus and pneumocystic infection, pulmonary tumor involvement, pulmonary lesions in ATRA-syndrome, non-infectious lesions of the lungs after bone marrow transplantation were found in 38, 18, 40, 18, 8 and 4% of cases, respectively.


CONCLUSIONS
DH patients with ARF should be examined by the protocol including both non-invasive and invasive diagnostic methods. Accurate diagnosis of ARF causes is the basic reserve in the treatment of such patients.
Galstian
G M
GM
Gorodetskiĭ
V M
VM
Gotman
L N
LN
Savchenko
V G
VG
Speranskaia
L L
LL
Tikhonova
L Iu
LIu
Shavlokhov
V S
VS
Karazhas
N V
NV
Rybalkina
T N
TN
Evseeva
L F
LF
D000208:Acute Disease; D000328:Adult; D001706:Biopsy; D001992:Bronchoalveolar Lavage Fluid; D003937:Diagnosis, Differential; D005260:Female; D006410:Hematopoiesis; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology*; D008171:Lung Diseases / Q000150:complications* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000503:physiopathology