[Changes of TF and TFPI activities in patients with hypertension or coronary atherosclerotic heart disease].
OBJECTIVE
To investigate the changes of tissue factor (TF) and tissue factor pathway inhibitor(TFPI) activities in patients with hypertension or coronary atherosclerotic heart (CAH) disease.


METHODS
TF activity was measured by two-stage assay, and TFPI activity was detected according to Sandset's method.


RESULTS
Plasma TF activity in both patients with hypertension and patients with CAH disease was higher than that of normal control(P < 0.05).


CONCLUSIONS
Hypercoagulative state may be involved in the pathogenetic processes of hypertension and CAH diseases. TF and TFPI activities have the likelihood to become the accessory diagnostic indexes for hypertension and CAH diseases.
Xiao
Z
Z
Department of Gerontology, Xianya Hospital, Hunan Medical University, Changsha 410008.
Wang
W
W
Han
J
J
He
X
X
Li
J
J
D000328:Adult; D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013925:Thromboplastin / Q000378:metabolism*
D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D013925:Thromboplastin