title: Disruption of adiponectin causes insulin resistance and neointimal formation.
abstract: The adipocyte-derived hormone adiponectin has been proposed to play important roles in the regulation of energy homeostasis and insulin sensitivity, and it has been reported to exhibit putative antiatherogenic properties in vitro. In this study we generated adiponectin-deficient mice to directly investigate whether adiponectin has a physiological protective role against diabetes and atherosclerosis in vivo. Heterozygous adiponectin-deficient (adipo(+/-)) mice showed mild insulin resistance, while homozygous adiponectin-deficient (adipo(-/-)) mice showed moderate insulin resistance with glucose intolerance despite body weight gain similar to that of wild-type mice. Moreover, adipo(-/-) mice showed 2-fold more neointimal formation in response to external vascular cuff injury than wild-type mice (p = 0.01). This study provides the first direct evidence that adiponectin plays a protective role against insulin resistance and atherosclerosis in vivo.
authors.affiliation: Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Kubota
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Terauchi
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kubota
authors.forename: Masao
authors.initials: M
authors.lastname: Moroi
authors.forename: Junji
authors.initials: J
authors.lastname: Matsui
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Eto
authors.forename: Tokuyuki
authors.initials: T
authors.lastname: Yamashita
authors.forename: Junji
authors.initials: J
authors.lastname: Kamon
authors.forename: Hidemi
authors.initials: H
authors.lastname: Satoh
authors.forename: Wataru
authors.initials: W
authors.lastname: Yano
authors.forename: Philippe
authors.initials: P
authors.lastname: Froguel
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kadowaki
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Noda
mesh_terms: D052242:Adiponectin; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D005951:Glucose Tolerance Test; D006579:Heterozygote; D006720:Homozygote; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D015430:Weight Gain / Q000235:genetics
chemical_list: D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids; D011506:Proteins