Effects of quinupristin/dalfopristin on vasomotor tone in the intact peripheral microcirculation.
The purpose of this study was to determine whether quinupristin/dalfopristin modulates vasomotor tone in the intact peripheral microcirculation. Using intravital microscopy, we found that superfusion of quinupristin/dalfopristin (120 mg/L) on the intact hamster cheek pouch microcirculation had no significant effects on arteriolar diameter. In addition, superfusion of quinupristin/dalfopristin (120 mg/L) had no significant effects on vasodilation evoked by bradykinin and acetylcholine, two endothelium-dependent agonists, or by vasoactive intestinal peptide, an endothelium-independent agonist, on to the cheek pouch. Collectively, these data indicate that quinupristin/dalfopristin has no significant effects on vasomotor tone in the intact peripheral microcirculation.
Tsueshita
Takaya
T
Department of Medicine, College of Medicine, University of Illinois at Chicago, 60612-7323, USA.
Gandhi
Salil
S
Rubinstein
Israel
I
D000818:Animals; D002610:Cheek / Q000098:blood supply; D006224:Cricetinae; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008647:Mesocricetus; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects / Q000502:physiology; D014769:Virginiamycin / Q000494:pharmacology*
D014665:Vasodilator Agents; D014769:Virginiamycin; C062940:quinupristin-dalfopristin