title: Computational and experimental simulations of the haemodynamics at cuffed arterial bypass graft anastomoses.
abstract: The development of intimal hyperplasia at arterial bypass graft anastomoses is a major factor responsible for graft failure. A revised surgical technique, involving the incorporation of a small section of vein (vein cuff) into the distal anastomosis of polytetrafluoroethylene (PTFE) grafts, alters the distribution of intimal hyperplasia and improves graft performance. Numerical and in vitro flow visualization experiments have been conducted to identify the flow behaviour in the cuffed bypass model and to determine whether the improved performance of the cuffed system can be accounted for by haemodynamic factors. The flowfield at the cuffed anastomosis is characterized by an expansive recirculation. Separation occurs at the graft heel, and at the cuff toe as the blood enters the recipient artery. Wall shear stresses in the vicinity of the cuff heel are low, but high shear stresses and large spatial gradients in the shearing force act for a time on the artery floor. In the conventional model, a less disturbed flow prevails while the gradients of shear stress on the floor are smaller. Aspects of the anastomotic haemodynamics are worsened when the cuff is employed. The superior patency rates of cuffed bypasses may not be explained purely on the basis of local haemodynamic factors.
authors.affiliation: School of Aeronautical Engineering, The Queen's University of Belfast, Northern Ireland, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Cole
authors.forename: L D
authors.initials: LD
authors.lastname: Wijesinghe
authors.forename: J K
authors.initials: JK
authors.lastname: Watterson
authors.forename: D J A
authors.initials: DJ
authors.lastname: Scott
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D001158:Arteries / Q000503:physiopathology* / Q000601:surgery; D001783:Blood Flow Velocity; D001807:Blood Vessel Prosthesis; D003198:Computer Simulation; D006439:Hemodynamics / Q000502:physiology*; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D013314:Stress, Mechanical