[Disruption of spatial memory in mice exposed to agroclavine].
The results of the study of the mnemotropic activity of the ergot alkaloid agroclavine are presented. Effects of this substance administered in doses of 1, 10, 25, 50, and 200 micrograms/kg on learning and spatial memory were studied in a Morris water maze. Agroclavine had no effect on learning but sharply impaired the retention. This memory impairment persisted for 48 h after the agroclavine administration. Agroclavine treatment did not affect the ability of mice to learn and retain a new skill. Possible mechanisms of the agroclavine effect on memory are discussed.
Bobkova
N V
NV
Institute of Cell Biophysics, Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Medical Sciences, Pushchino.
Medvinskaia
N I
NI
Nesterova
I V
IV
Arinbasarov
M U
MU
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D004873:Ergolines / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051379:Mice
D000903:Antibiotics, Antineoplastic; D004873:Ergolines; C004465:agroclavine