[Effect of Gastrodia on rotation induced motion sickness in mice].
OBJECTIVE
To observe the effect of Gastrodia on motion sickness induced by rotation in mice.


METHODS
Clockwise and anticlockwise accelerated rotations up to 180 degrees/s for 10 min were used to induce symptoms of motion sickness such as condition taste aversion (CTA), decrease of spontaneous locomotion and impaired ability of space identification in water-maze.


RESULTS
Gastrodia could improve the response of CTA, increase spontaneous locomotion, and enhance the ability of learning and memory in water-maze in mice after the rotation.


CONCLUSIONS
Symptoms of motion sickness induced by rotation could be improved by Gastrodia treatment.
Wang
S P
SP
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Liu
X M
XM
Shang
W F
WF
Song
J
J
Yu
S R
SR
Sun
S M
SM
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use*; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D009041:Motion Sickness / Q000188:drug therapy* / Q000209:etiology; D009043:Motor Activity / Q000187:drug effects; D012399:Rotation / Q000009:adverse effects*; D013037:Spatial Behavior / Q000187:drug effects; D013649:Taste / Q000187:drug effects; D014867:Water
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D014867:Water