Comparative assessment of endocrine modulators with oestrogenic activity. II. Persistent organochlorine pollutants.
Risk assessments of synthetic chemicals with oestrogen-like activity must take into account the high dietary levels of natural endocrine modulators in food. In view of current regulations of the European Union, a hygiene-based margin of safety (HBMOS) for xeno-oestrogens was defined as a quotient of estimated human daily intakes weighted by relative rodent in vivo potencies of the compounds. Such comparisons of intakes and potencies of natural isoflavones, with short half-lives, with those of polychlorinated organic pollutants (POP) displaying significant toxicokinetic accumulation, deserves the special consideration of toxicokinetics. For slowly accumulating compounds such comparison is much more favourable when based on comparative blood and tissue levels, not on scenarios of daily exposures. Observing these principles, the present communication extends the HBMOS concept to POP, using o,p'-DDT, the oestrogenic component of DDT mixtures, as a prototype. An HBMOS of 137 is derived for o,p'-DDT indicative of a sufficient margin of safety to ensure the absence of risk to human health due to its hormonal action, under exposure conditions now prevailing in Western countries.
Bolt
Hermann M
HM
Institut für Arbeitsphysiologie an der Universität Dortmund, Ardeystr. 67, 44139 Dortmund, Germany. bolt@arb-phys.uni-dortmund.de
Degen
Gisela H
GH
D000818:Animals; D003634:DDT / Q000493:pharmacokinetics / Q000633:toxicity; D004703:Endocrine System / Q000187:drug effects; D004785:Environmental Pollutants / Q000493:pharmacokinetics* / Q000633:toxicity; D045166:Estradiol Congeners / Q000493:pharmacokinetics* / Q000633:toxicity; D004968:Estrogens, Non-Steroidal / Q000493:pharmacokinetics / Q000633:toxicity; D005062:European Union; D005506:Food Contamination / Q000331:legislation & jurisprudence; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000493:pharmacokinetics* / Q000633:toxicity; D007529:Isoflavones; D008731:Methoxychlor / Q000493:pharmacokinetics / Q000633:toxicity; D010575:Pesticides / Q000493:pharmacokinetics / Q000633:toxicity; D048789:Phytoestrogens; D028321:Plant Preparations; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics / Q000633:toxicity; D000072317:Polychlorinated Dibenzodioxins / Q000493:pharmacokinetics / Q000633:toxicity; D051381:Rats
D004785:Environmental Pollutants; D045166:Estradiol Congeners; D004968:Estrogens, Non-Steroidal; D006843:Hydrocarbons, Chlorinated; D007529:Isoflavones; D010575:Pesticides; D048789:Phytoestrogens; D028321:Plant Preparations; D000072317:Polychlorinated Dibenzodioxins; D003634:DDT; D011078:Polychlorinated Biphenyls; D008731:Methoxychlor