Genetic susceptibility to chronic lymphocytic leukemia.
There is increasing evidence that a subset of chronic lymphocytic leukemia is caused by an inherited predisposition. Here we review the evidence for an inherited predisposition, the characteristics of familial cases and evidence for the involvement of specific genes.
Houlston
R S
RS
Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK.
Catovsky
D
D
Yuille
M R
MR
D005192:Family Health; D005803:Genes, Immunoglobulin; D020022:Genetic Predisposition to Disease; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology / Q000235:genetics*; D009154:Mutation; D010375:Pedigree