title: Anatomic study of submandibular gland transfer in an attempt to prevent postradiation xerostomia.
abstract: Xerostomia is the most common negative sequela after radiotherapy for head and neck cancer and results from destruction of normal salivary gland tissue by radiation. We hypothesized that transferring a single submandibular gland outside the radiation field to the submental region may preserve its function, thus preventing xerostomia and its consequences. This anatomic study was designed to evaluate different methods of submandibular gland transfer to the submental region. Eight submandibular glands were dissected in four fresh human cadavers. The anatomy and blood supply of the region were documented. Each gland was transferred to the submental region by either free microvascular transfer or based on retrograde flow through the distal facial vessels. Both methods of transfer resulted in complete relocation of the submandibular gland into the submental region.
authors.affiliation: Division of Otolaryngology-Head and Neck Surgery, University of Alberta, Edmonston.
authors.forename: Richard
authors.initials: R
authors.lastname: Liu
authors.forename: Hadi
authors.initials: H
authors.lastname: Seikaly
authors.forename: Naresh
authors.initials: N
authors.lastname: Jha
mesh_terms: D002102:Cadaver; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D011832:Radiation Injuries / Q000517:prevention & control / Q000601:surgery*; D011878:Radiotherapy / Q000009:adverse effects; D013363:Submandibular Gland / Q000098:blood supply* / Q000637:transplantation*; D014182:Transplantation, Autologous; D014987:Xerostomia / Q000209:etiology* / Q000517:prevention & control / Q000601:surgery*