Immunogenetics of autoimmune diseases in Asian Indians.
The HLA class II molecules play a critical role in the processing and presentation of specific peptides derived from autoantigens of pancreatic beta cells or gluten for T cell scrutiny in IDDM and CD. In the present study, extended DR3-positive haplotypes associated with autoimmunity in northern Indian patients have been reported. The haplotype A26-B8-DR3 was the most common autoimmunity-favoring haplotype encountered among these patients. This association is, indeed, unique to Indian autoimmune patients, as it replaces the otherwise most commonly associated Caucasian haplotype A1-B8-DR3 (AH8.1) in this population. Further, CD patients revealed 100% association with DQB1*0201 along with DQA*0501 (97%) either in cis or trans configuration.
Mehra
N K
NK
Department of Histocompatibility & Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. narin98@hotmail.com
Kaur
Gurvinder
G
Kanga
Uma
U
Tandon
Nikhil
N
D044466:Asian People / Q000235:genetics*; D002446:Celiac Disease / Q000235:genetics* / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D015803:HLA-DR3 Antigen / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007194:India; D008297:Male
D006683:HLA-DQ Antigens; D015803:HLA-DR3 Antigen