Tissue adhesive and postoperative allergic meningitis.
Adhesives containing cyanoacrylate are used in many surgical procedures, including closure of skin wounds and reinforcement of intracranial aneurysm repairs. A 61-year-old woman developed fever, neck stiffness, and cerebrospinal fluid eosinophilia after an operation for an intracranial aneurysm. We suspected allergic meningitis due to a foreign substance. To detect the cause of this disorder, we did 2-day closed patch testing with the substances thought to be possible allergens. We recorded a positive reaction to methyl-2-cyanoacrylate, the main ingredient of Biobond, the tissue adhesive used in the surgery. This substance could have caused postoperative allergic meningitis.
Kitoh
Akihiko
A
Department of Dermatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan. kichu@kuhp.kyoto-u.ac.jp
Arima
Yaeno
Y
Nishigori
Chikako
C
Kikuta
Ken ichiro
Ki
Miyachi
Yoshiki
Y
D003487:Cyanoacrylates / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D008581:Meningitis / Q000209:etiology*; D008875:Middle Aged; D010328:Patch Tests; D011183:Postoperative Complications / Q000209:etiology*; D014014:Tissue Adhesives / Q000009:adverse effects*
D003487:Cyanoacrylates; D014014:Tissue Adhesives