Helicobacter pylori primary resistance to metronidazole and clarithromycin in Brazil.
Helicobacter pylori resistance to metronidazole was detected in 107 (52.97%) of 202 strains. Twenty (9.85%) strains, 18 of them harboring 23S ribosomal DNA mutations, were resistant to clarithromycin. Metronidazole resistance was associated with female gender. Resistance to metronidazole and resistance to clarithromycin were associated. Increasing clarithromycin resistance rates were observed over time.
Prazeres Magalhães
Paula
P
Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
De Magalhães Queiroz
Dulciene Maria
DM
Campos Barbosa
Daniela Vale
DV
Aguiar Rocha
Gifone
G
Nogueira Mendes
Edilberto
E
Santos
Adriana
A
Valle Corrêa
Paulo Renato
PR
Camargos Rocha
Andreia Maria
AM
Martins Teixeira
Lúcia
L
Affonso de Oliveira
Celso
C
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000378:metabolism; D001938:Brazil / Q000453:epidemiology; D017291:Clarithromycin / Q000627:therapeutic use*; D004269:DNA, Bacterial / Q000235:genetics; D004352:Drug Resistance, Microbial; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use*; D017354:Point Mutation
D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C080866:cagA protein, Helicobacter pylori; D008795:Metronidazole; D017291:Clarithromycin