title: Conjugated linoleic acid reduces body fats and cytokine levels of mice.
abstract: In order to discover the effect of CLA on the body fat size and serum cytokine levels, four groups of male mice were fed diets containing either 1% linoleic acid (LA) or conjugated linoleic acid (CLA) with or without 0.2% sesamin for 8 weeks. The weight gain and feed efficiency were significantly lower in the CLA groups. CLA significantly reduced relative weights (g/100 g body weight) of epididymal and perirenal adipose tissues, in particular the former. Concentrations of serum TNF-alpha and leptin were significantly reduced by dietary CLA. Sesamin did not show additional effects in all of these parameters. There was a positive correlation between cytokine production and body-fat reducing potential of CLA. These results indicated that mice appeared to be a hyperresponder to dietary CLA insofar as the reduction of body fat size is concerned.
authors.affiliation: Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Japan. a-asuka@pu-kumamoto.ac.jp
authors.forename: Asuka
authors.initials: A
authors.lastname: Akahoshi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Goto
authors.forename: Kayoko
authors.initials: K
authors.lastname: Murao
authors.forename: Tomoko
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Masao
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Michiko
authors.initials: M
authors.lastname: Nonaka
authors.forename: Koji
authors.initials: K
authors.lastname: Yamada
authors.forename: Michihiro
authors.initials: M
authors.lastname: Sugano
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D016207:Cytokines / Q000187:drug effects / Q000378:metabolism*; D004041:Dietary Fats / Q000494:pharmacology*; D002149:Energy Intake / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D019787:Linoleic Acid / Q000494:pharmacology; D008041:Linoleic Acids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects
chemical_list: D016207:Cytokines; D004041:Dietary Fats; D008041:Linoleic Acids; D019787:Linoleic Acid