Synthesis of oligodeoxyribonucleoside phosphorothioates using Lawesson's reagent for the sulfur transfer step.
2,4-Bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawesson's reagent) efficiently converts the triphosphite intermediate used in the solid-phase synthesis of oligonucleotides into an oligodeoxyribonucleoside phosphorothioate.
Ju
Jingyue
J
Department of Chemistry, University of Southern California, Los Angeles, CA 90089-0744, USA.
McKenna
Charles E
CE
D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000737:chemistry
D009705:Nucleosides; D009943:Organophosphorus Compounds; D013873:Thionucleotides