[G-CSF and GM-CSF in treatment of neutropaenia after chemotherapy in children with neoplasms].
A total number of 608 cycles of G-CSF and/or GM-CSF was applied in 280 patients aged from 6 months to 20 years during neutropaenia associated with chemotherapy of children's neoplasms (NHL-124, NBL-42, RMS-36, Nephroblastoma-18, Osteosarcoma-17, Ewing's Sarcoma-14, Hepatoblastoma-6, Neurofibrosarcoma-6, PNET-5, Medulloblastoma-3, Fibrohistiocytoma-3, Angiosarcoma-2, other - 4). G-CSF - Neupogen (Filgastrim, Hoffman La Roche - 492 cycles) and GM-CSF - Leucomax (Molgramostim, Shering Plough - 116 cycles) were administered 5 mg/kg/day s.c. Forty one children with malignancies (NHL -21 cases, solid tumours -17) treated before cytokines were in use served as a control group. Our study demonstrated that G-CSF and GM-CSF therapy, gives a shorter period of neutropaenia, reduction of the number of febrile days, decreased frequency of infection and shortened its duration.
Chybicka
A
A
Katedra i Klinika Hematologii i Chorób Rozrostowych Dzieci, 50-345 Wroclaw, Bujwida 44, Poland.
Bogusławska-Jaworska
J
J
Rosińska
B
B
Wecławek-Tompol
J
J
Armata
J
J
Balcerska
A
A
Balwierz
W
W
Bubala
H
H
Drabko
K
K
Eliasinska
A
A
Kedziora
M
M
Sońta-Jakimczyk
D
D
Sopylo
B
B
Kołecki
P
P
Kowalczyk
J
J
Matysiak
M
M
Rokicka-Milewska
R
R
Stefaniak
M J
MJ
Stańczak
E
E
Stencel
D
D
Wysocki
M
M
Płoszyńska
A
A
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000188:drug therapy; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy*; D016019:Survival Analysis; D013997:Time Factors
D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor