Conjugated linoleic acid reduces body fats and cytokine levels of mice.
In order to discover the effect of CLA on the body fat size and serum cytokine levels, four groups of male mice were fed diets containing either 1% linoleic acid (LA) or conjugated linoleic acid (CLA) with or without 0.2% sesamin for 8 weeks. The weight gain and feed efficiency were significantly lower in the CLA groups. CLA significantly reduced relative weights (g/100 g body weight) of epididymal and perirenal adipose tissues, in particular the former. Concentrations of serum TNF-alpha and leptin were significantly reduced by dietary CLA. Sesamin did not show additional effects in all of these parameters. There was a positive correlation between cytokine production and body-fat reducing potential of CLA. These results indicated that mice appeared to be a hyperresponder to dietary CLA insofar as the reduction of body fat size is concerned.
Akahoshi
Asuka
A
Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Japan. a-asuka@pu-kumamoto.ac.jp
Goto
Yuki
Y
Murao
Kayoko
K
Miyazaki
Tomoko
T
Yamasaki
Masao
M
Nonaka
Michiko
M
Yamada
Koji
K
Sugano
Michihiro
M
D000273:Adipose Tissue / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D016207:Cytokines / Q000187:drug effects / Q000378:metabolism*; D004041:Dietary Fats / Q000494:pharmacology*; D002149:Energy Intake / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D019787:Linoleic Acid / Q000494:pharmacology; D008041:Linoleic Acids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects
D016207:Cytokines; D004041:Dietary Fats; D008041:Linoleic Acids; D019787:Linoleic Acid