Major role for the carboxylic function of cetirizine and levocetirizine in their binding characteristics to human H1-histamine-receptors.
Gillard
M
M
UCB Pharma Sector, In Vitro Pharmacology, Chemin Du Foriest, Braine l'Alleud, Belgium. michel.gillard@ucb-group.com
Van der Perren
C
C
Moguilevsky
N
N
Massingham
R
R
Chatelain
P
P
D000818:Animals; D016466:CHO Cells; D002264:Carboxylic Acids / Q000737:chemistry / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D017332:Cetirizine / Q000737:chemistry* / Q000378:metabolism*; D003001:Cloning, Molecular; D006224:Cricetinae; D006634:Histamine H1 Antagonists / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008239:Lysine / Q000737:chemistry / Q000378:metabolism; D016297:Mutagenesis, Site-Directed; D013237:Stereoisomerism
D002264:Carboxylic Acids; D006634:Histamine H1 Antagonists; D008239:Lysine; D017332:Cetirizine