title: Nicotinanilides as inhibitors of neutrophil chemotaxis.
abstract: A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and allergic disorders.
authors.affiliation: Department of Chemistry, Celltech R&D Inc., 1631 220th Street SE, Bothell, WA 98021, USA. ncutshall@ceptyr.com
authors.forename: Neil S
authors.initials: NS
authors.lastname: Cutshall
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Kucera
authors.forename: Rocky
authors.initials: R
authors.lastname: Ursino
authors.forename: John
authors.initials: J
authors.lastname: Latham
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Ihle
mesh_terms: D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D009504:Neutrophils / Q000187:drug effects*; D009539:Nicotinic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D009539:Nicotinic Acids; C038997:nicotinanilide