title: Supplemental fructose attenuates postprandial glycemia in Zucker fatty fa/fa rats.
abstract: Experiments were conducted to evaluate the effects of supplemental fructose on postprandial glycemia. After overnight food deprivation, Zucker fatty fa/fa rats were given a meal glucose tolerance test. Plasma glucose response was determined for 180 min postprandially. At a dose of 0.16 g/kg body, fructose reduced (P < 0.05) the incremental area under the curve (AUC) by 34% when supplemented to a glucose challenge and by 32% when supplemented to a maltodextrin (a rapidly digested starch) challenge. Similarly, sucrose reduced (P = 0.0575) the incremental AUC for plasma glucose when rats were challenged with maltodextrin. Second-meal glycemic response was not affected by fructose supplementation to the first meal, and fructose supplementation to the second meal reduced (P < 0.05) postprandial glycemia when fructose had been supplemented to the first meal. In a dose-response study (0.1, 0.2, and 0.5 g/kg body), supplemental fructose reduced (P < 0.01) the peak rise in plasma glucose (linear and quadratic effects). In the final experiment, a low dose of fructose (0.075 g/kg body) reduced (P < 0.05) the incremental AUC by 18%. These data support the hypothesis that small amounts of oral fructose or sucrose may be useful in lowering the postprandial blood glucose response.
authors.affiliation: Ross Products Division, Abbott Laboratories, Columbus, OH 43215, USA. bryan.wolf@abbott.com
authors.forename: Bryan W
authors.initials: BW
authors.lastname: Wolf
authors.forename: Phillip M
authors.initials: PM
authors.lastname: Humphrey
authors.forename: Craig W
authors.initials: CW
authors.lastname: Hadley
authors.forename: Kati S
authors.initials: KS
authors.lastname: Maharry
authors.forename: Keith A
authors.initials: KA
authors.lastname: Garleb
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Firkins
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism*; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy / Q000378:metabolism; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005632:Fructose / Q000008:administration & dosage* / Q000378:metabolism*; D005951:Glucose Tolerance Test; D011134:Polysaccharides / Q000008:administration & dosage / Q000378:metabolism; D019518:Postprandial Period / Q000502:physiology*; D051381:Rats; D011924:Rats, Zucker; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D011134:Polysaccharides; D005632:Fructose; C008315:maltodextrin