8-Methoxyquinolines as PDE4 inhibitors.
The synthesis and pharmacological profile of a novel series of 2-substituted 8-methoxyquinolines is described. The 2-trifluoromethyl compound was found to be a potent inhibitor of phosphodiesterase type 4 (PDE4).
Billah
Motasim
M
Schering-Plough Corporation, Galloping Hill Road, Kenilworth, NJ 07033-0530, USA.
Buckley
George M
GM
Cooper
Nicola
N
Dyke
Hazel J
HJ
Egan
Robert
R
Ganguly
Ashit
A
Gowers
Lewis
L
Haughan
Alan F
AF
Kendall
Hannah J
HJ
Lowe
Christopher
C
Minnicozzi
Michael
M
Montana
John G
JG
Oxford
Janet
J
Peake
Joanna C
JC
Picken
C Louise
CL
Piwinski
John J
JJ
Naylor
Robert
R
Sabin
Verity
V
Shih
Neng-Yang
NY
Warneck
Julie B H
JB
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D019540:Area Under Curve; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D006168:Guinea Pigs; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D014839:Vomiting / Q000139:chemically induced
D010726:Phosphodiesterase Inhibitors; D011804:Quinolines; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4