Structural biology of metal-binding sequences.
NMR spectroscopy and X-ray crystallography in conjunction with extended X-ray absorption fine structure spectroscopy, have contributed to the elucidation of the structural biology of protein-mediated mechanisms of heavy metal homeostasis. Among the most striking aspects of these investigations are the remarkable similarity of metal-ion-transport and sequestering systems across different species, and the need to continue the research to confirm hypotheses for the molecular mechanisms of transfers of metal ions between proteins.
Opella
Stanley J
SJ
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0307, USA.
DeSilva
Tara M
TM
Veglia
Gianluigi
G
D000595:Amino Acid Sequence; D001665:Binding Sites / Q000235:genetics; D001692:Biological Transport; D008667:Metalloproteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008670:Metals / Q000378:metabolism* / Q000494:pharmacology; D017434:Protein Structure, Tertiary / Q000187:drug effects
D008667:Metalloproteins; D008670:Metals