title: Height distribution in children with Tourette syndrome.
abstract: Tourette syndrome is characterized by motor and vocal tics, frequently accompanied by attention-deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder, coprolalia, aggressive or self-injurious behavior, and learning disabilities. We investigated the height distribution and clinical characteristics of 38 consecutive patients with Tourette syndrome. Seventeen patients with Tourette syndrome (44.7%) were in the lower height quartile versus 25% from a control group of 44 patients with ADHD (P <.05). The mean standard deviation score differential (patient height - [target height]) was -1.12 +/- 0.82 for patients in the first quartile (group A) compared with 0.42 +/- 0.63 in taller patients with Tourette syndrome (group B) (P < .001). The mean birthweight of boys in group A versus group B was 3023 +/- 351 g and 3363 +/- 486 g, respectively (P <.02); birthweight correlated with standard deviation score (r=.43). Current weight relative to height was normal. Conduct disorder and/or self-injurious behavior were more common in group A patients (P < .05). Relative short stature appears common in Tourette syndrome, and its presence with other features may implicate a neurotransmitter system that interacts with neuroendocrine pathways, controlling height.
authors.affiliation: Department of Pediatrics, Carmel Medical Center and the B Rappaport Faculty of Medicine, Technion, Haifa, Israel. zelnik@attglobal.net
authors.forename: Nathanel
authors.initials: N
authors.lastname: Zelnik
authors.forename: Ron S
authors.initials: RS
authors.lastname: Newfield
authors.forename: Zmira
authors.initials: Z
authors.lastname: Silman-Stolar
authors.forename: Igor
authors.initials: I
authors.lastname: Goikhman
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology; D001724:Birth Weight; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007859:Learning Disabilities / Q000453:epidemiology; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology*; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology; D013064:Speech Disorders / Q000453:epidemiology; D020323:Tics / Q000453:epidemiology; D005879:Tourette Syndrome / Q000453:epidemiology* / Q000503:physiopathology*