Iodopropynyl butylcarbamate.
Iodopropynyl butylcarbamate (IPBC) is an internationally recognized chemical that has been used for years because of its wide field of application. Initially used as a water-based paint and wood preservative and then in metalworking fluids, its role has expanded into the more recent uses in cosmetic products. The need for a potent, broad-spectrum, and safe preservative system in cosmetics allowed for the discovery of several combinations of IPBC effective against a wide variety of organisms. Although IPBC has claimed to be safe when used at concentrations less than 0.1%, the introduction of IPBC into cosmetics has led to several reports labeling IPBC as a potential new contact allergen. As the use of this seemingly safe preservative becomes vast, an increased number of cases of IPBC-induced contact allergy is likely.
Badreshia
Sonia
S
Department of Dermatology, Penn State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, PA, USA.
Marks
James G
JG
D000485:Allergens / Q000009:adverse effects*; D002219:Carbamates / Q000009:adverse effects*; D003358:Cosmetics / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D006801:Humans; D010328:Patch Tests / Q000592:standards; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*
D000485:Allergens; D002219:Carbamates; D003358:Cosmetics; D011310:Preservatives, Pharmaceutical; C106572:3-iodo-2-propynylbutylcarbamate