title: [Biochemical mechanisms of genome-protective activity of pyridine carbonic acid new derivatives with cells damaged by tetrachloromethane].
abstract: The biochemical mechanisms of genomoprotective action of the new derivatives of pyridinecarbonic acids--PV-3, PV-4 and PV-6 in the conditions of tetrachloromethane chemical cell damage have been studied. This effect is related to their antioxidant influence on LPO processes in transcriptionally active and repressed chromatin fractions of rat liver cells and partial restoration of these fractions structure which has been destroyed during intoxication. PV-4 possesses the most genoprotective activity among the substances studied.
authors.affiliation: Institute of Pharmacology and Toxicology, AMS of Ukraine, Kyiv.
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Hubs'kyĭ
authors.forename: Ie L
authors.initials: IeL
authors.lastname: Levyts'kyĭ
authors.forename: H H
authors.initials: HH
authors.lastname: Horiushko
authors.forename: O M
authors.initials: OM
authors.lastname: Marchenko
authors.forename: R H
authors.initials: RH
authors.lastname: Prymak
authors.forename: V P
authors.initials: VP
authors.lastname: Danylenko
authors.forename: V M
authors.initials: VM
authors.lastname: Ovruts'tkyĭ
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D002255:Carbonic Acid / Q000737:chemistry / Q000494:pharmacology*; D016678:Genome; D008099:Liver / Q000187:drug effects*; D008297:Male; D011725:Pyridines / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016587:Antimutagenic Agents; D011725:Pyridines; D002255:Carbonic Acid; D002251:Carbon Tetrachloride; C023666:pyridine