Pharmacokinetics of new anticonvulsants in psychiatry.
The newer AEDs have potential in the treatment of psychiatric disorders. In light of this expanding spectrum of activity, it is necessary to refine and focus the safety and efficacy of the use of these agents among a wider population. The classic AEDs had numerous problems, ranging from inconvenient dosing schedules to frequent side effects due to active metabolites and common drug interactions; newer agents have been developed to avoid some of these pitfalls. Indeed, a generation of drugs that appears to have relatively simple pharmacokinetics and limited drug interactions--making them safer and easier to administer--is now available. The use of these agents in psychiatry will necessitate additional investigation into their dosing and administration guidelines, as well as their interactions with other common psychiatric or concomitant drugs. Certainly, over time, they will be evaluated for these parameters in the newer indications. In the meantime, a review of the established pharmacokinetic and pharmacodynamic activities of these agents is the first step in defining their optimal uses and limitations in the psychiatric setting.
Morris
H H
HH
Department of Neurology, Section of Epilepsy and Sleep Disorders, The Cleveland Clinic Foundation, Ohio 44195, USA.
D000085:Acetates / Q000493:pharmacokinetics / Q000627:therapeutic use; D000588:Amines; D000927:Anticonvulsants / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids; D004347:Drug Interactions; D000078328:Felbamate; D005632:Fructose / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000627:therapeutic use; D000077206:Gabapentin; D006801:Humans; D000077213:Lamotrigine; D001523:Mental Disorders / Q000188:drug therapy*; D009557:Nipecotic Acids / Q000493:pharmacokinetics / Q000627:therapeutic use; D048448:Phenylcarbamates; D011409:Propylene Glycols / Q000493:pharmacokinetics / Q000627:therapeutic use; D011570:Psychiatry / Q000639:trends; D000078308:Tiagabine; D000077236:Topiramate; D014227:Triazines / Q000493:pharmacokinetics / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D009557:Nipecotic Acids; D048448:Phenylcarbamates; D011409:Propylene Glycols; D014227:Triazines; D000077236:Topiramate; D005632:Fructose; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D000077213:Lamotrigine; D000078328:Felbamate; D000078308:Tiagabine