title: Absolute risk or relative risk? A study of intraspecies and interspecies extrapolation of chemical-induced cancer risk.
abstract: We have used the CBDS database of the National Toxicology Program to study the difference between absolute risk and relative risk models for interspecies and intersex predictions of cancer risk. For no combination (class) of tumor and site is the prediction good for all chemicals. The variation in predicted risk between chemicals exceeds the difference in risks resulting from application of these two models. On the whole, it appears that relative risk is a better model.
authors.affiliation: Department of Physics and Center for Risk Analysis, Harvard University, Cambridge, MA, USA.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Kuo
authors.forename: Igor
authors.initials: I
authors.lastname: Linkov
authors.forename: Lorenz
authors.initials: L
authors.lastname: Rhomberg
authors.forename: Michael
authors.initials: M
authors.lastname: Polkanov
authors.forename: George
authors.initials: G
authors.lastname: Gray
authors.forename: Richard
authors.initials: R
authors.lastname: Wilson
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity; D009369:Neoplasms / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D018570:Risk Assessment; D013045:Species Specificity
chemical_list: D002273:Carcinogens; D006843:Hydrocarbons, Chlorinated; D009153:Mutagens