Vitamin B12 deficiency, tumor necrosis factor-alpha, and epidermal growth factor: a novel function for vitamin B12?
Vitamin B12 deficiency was recently shown to be associated with elevated levels of tumor necrosis factor-alpha and decreased levels of epidermal growth factor in both rats and humans. These findings suggest a novel pathogenetic mechanism underlying the neuropathology of vitamin B12 deficiency. They may also explain putative relationships between vitamin B12 deficiency and certain disorders, including Alzheimer's disease, rheumatoid arthritis, and AIDS.
Miller
Joshua W
JW
University of California, Davis, Medical Center, Department of Medical Pathology, Sacramento 95817, USA.
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology; D000544:Alzheimer Disease / Q000209:etiology; D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000209:etiology; D004815:Epidermal Growth Factor / Q000032:analysis*; D006801:Humans; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000150:complications / Q000503:physiopathology*
D000970:Antineoplastic Agents; D014409:Tumor Necrosis Factor-alpha; D004815:Epidermal Growth Factor