Scanning laser ophthalmoscope-evoked multifocal-ERG (SLO-m-ERG) by using short m-sequences.
OBJECTIVE
To demonstrate the possibility of topographic mapping of retinal function under simultaneous control of fixation in humans, by scanning laser ophthalmoscope evoked multifocal electroretinography (SLO-m-ERG).


METHODS
A confocal scanning laser ophthalmoscope was used as a stimulator and trigger unit to take m-ERGs. Short m-sequences based on a modified algorithm were used, with the advantage that each measurement cycle can be evaluated separately. We examined 78 normal subjects; in 62 a distortion factor of 1:1 was applied, and a factor of 1:4 in 16.


RESULTS
The recorded amplitudes decreased with eccentricity, approximately following the decrease of retinal cone density. Amplitudes were higher in the central hexagonal element in the group with 1:4 distortion than in the group with the 1:1 distortion setting.


CONCLUSIONS
SLO-m-ERG is a reliable technique for topographic mapping of retinal function under simultaneous control of fixation.
Rudolph
G
G
Eye Clinic, Ludwig-Maximilians-University, Munich, Germany. Guenther.Rudolph@ak-i.med.uni-muenchen.de
Kalpadakis
P
P
Bechmann
M
M
La Rocca
G
G
Hörmann
C
C
Berninger
T
T
D000328:Adult; D000465:Algorithms; D004596:Electroretinography / Q000379:methods*; D006801:Humans; D007834:Lasers; D008875:Middle Aged; D019721:Ophthalmoscopes; D012160:Retina / Q000502:physiology*