title: Adherence to HAART among patients with HIV: breakthroughs and barriers.
abstract: Highly active antiretroviral therapy (HAART) has been a major breakthrough for the treatment of patients with HIV; however, adherence to treatment remains a formidable barrier. This paper evaluates the current state-of-the-science in adherence to HAART. Barriers to treatment success, determinants of adherence and interventions to improve adherence are reviewed. Overall, multifaceted interventions appear most promising. We conclude with recommendations to enhance clinical practice and improve treatment outcomes for patients with HIV. Despite substantial attention to adherence in recent years, much more remains to be done to understand and promote adherence to HAART.
authors.affiliation: Yale University, School of Medicine, Department of Epidemiology and Public Health, New Haven, CT 06520-8034, USA. Jeannette.Ickovics@yale.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Ickovics
authors.forename: C S
authors.initials: CS
authors.lastname: Meade
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000523:psychology / Q000706:statistics & numerical data*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D010349:Patient Compliance / Q000523:psychology / Q000706:statistics & numerical data*; D012307:Risk Factors