Discrimination between cases of duodenal ulcer and gastritis on the basis of putative virulence factors of Helicobacter pylori.
The BabA, cagA, and vacA statuses of 827 Helicobacter pylori isolates were used in logistic regression models to discriminate duodenal ulcer from gastritis. Only BabA was a candidate for a universal virulence factor, but the low c statistic value (0.581) indicates that none of these factors were helpful in predicting the clinical presentation.
Yamaoka
Yoshio
Y
Department of Medicine. Department of Health Services Research, Baylor College of MedicineVeterans Affairs Medical Center, Houston, Texas 77030, USA. yyamaoka@bcm.tmc.edu
Souchek
Julianne
J
Odenbreit
Stefan
S
Haas
Rainer
R
Arnqvist
Anna
A
Borén
Thomas
T
Kodama
Tadashi
T
Osato
Michael S
MS
Gutierrez
Oscar
O
Kim
Jong G
JG
Graham
David Y
DY
D018829:Adhesins, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D004381:Duodenal Ulcer / Q000175:diagnosis* / Q000382:microbiology*; D005756:Gastritis / Q000175:diagnosis* / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D016015:Logistic Models; D014774:Virulence
D018829:Adhesins, Bacterial; D000942:Antigens, Bacterial; C400429:BabA protein, Helicobacter pylori; D001426:Bacterial Proteins; D002352:Carrier Proteins; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori