[Schistosoma japonicum: protective immunity induced in mice immunized with SjGST-Sj32].
Schistosoma japonicum glutathione-s-transferase (SjGST), Schistosoma japonicum 32,000 protein (Sj32) and SjGST - Sj32 were expressed and purified to study on protective immunity against Schistosoma japonicum. The result showed that compared with the adjuvant control group, the worm burden was decreased significantly in mice immunized with recombinant SjGST - Sj32, Sj32 and Sj32 + SjGST (P < 0.05). At the same time, the liver egg per gram(EPG) was decreased in mice immunized with SjGST - Sj32, Sj32, Sj32 + SjGST and SjGST. It is concluded that Sj32 significantly induces both protective immunity and anti-fecundity immunity, but SjGST only has an anti-fecundity effect.
Cai
C
C
Department of Parasitology, Hunan Medical University, Changsha 410078.
Yi
X
X
Zeng
X
X
Zhou
J
J
Shu
X
X
D000818:Animals; D005982:Glutathione Transferase / Q000276:immunology*; D015801:Helminth Proteins / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation; D011994:Recombinant Proteins / Q000276:immunology; D012549:Schistosoma japonicum / Q000737:chemistry / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology
D015801:Helminth Proteins; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic; D005982:Glutathione Transferase