Lipiodol versus methylene blue for prevention of postsurgical adhesion formation in a rat model.
OBJECTIVE
To determine the effects of intraperitoneal Lipiodol and methylene blue in prevention of postsurgical adhesion formation.


METHODS
Thirty female rats were divided into three equal groups and a standard damage to provoke adhesion formation was made by laparotomy to each of them. Methylene blue and Lipiodol was administered intraperitoneally to the first and second groups, respectively; while the third group was taken as control and no additional intervention was made. Adhesions were scored by a second look laparotomy which was made 21 days after the first operation.


RESULTS
Adhesion scores of the second group (i.e. Lipiodol group) were significantly lower than that of controls. No significant differences were present between any other groups (i.e. methylene blue versus control and methylene blue versus Lipiodol).


CONCLUSIONS
Intraperitoneal administration of Lipiodol inhibits postsurgical adhesion formation in rats.
Duran
Hakan E
HE
Department of Obstetrics and Gynecology, Baskent University School of Medicine, Ankara, Turkey. hakan_duran@hotmail.com
Kuscu
Esra
E
Zeyneloglu
Hulusi B
HB
Saygili
Esra
E
Batioglu
Sertac
S
D000818:Animals; D005260:Female; D007459:Iodized Oil / Q000627:therapeutic use*; D008751:Methylene Blue / Q000627:therapeutic use*; D010537:Peritoneum / Q000187:drug effects; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control*
D007459:Iodized Oil; D008751:Methylene Blue