[Synthesis and antiosteoporosis activity of steroid-bisphosphonate compounds].
Bisphosphonate have bone-seeking affinity, some of them are used as drugs for osteoporosis. Steroidal hormones are often used in prevention and treatment of osteoporosis. In order to search for bone-targeted leading compounds with high affinity and low toxicity, seven steroid-bisphosphonate compounds were synthesized. These compounds were found to promote bone formation in bone cell culture.
Zheng
H
H
School of Pharmacy, West China University of Medical Sciences, Chengdu 610041.
Wu
Y
Y
Chen
J
J
Weng
L
L
D000818:Animals; D046508:Culture Techniques; D004164:Diphosphonates / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D015394:Molecular Structure; D010012:Osteogenesis / Q000187:drug effects*; D010024:Osteoporosis / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D012886:Skull / Q000502:physiology; D013256:Steroids / Q000138:chemical synthesis* / Q000494:pharmacology
D004164:Diphosphonates; D013256:Steroids