Geographic variations in breast cancer survival among older women: implications for quality of breast cancer care.
BACKGROUND
Breast cancer care, such as utilization of screening procedures and types of treatment received, varies substantially by geographic region of the United States. However, little is known about variations in survival with breast cancer.


METHODS
We examined breast cancer incidence, survival, and mortality in the 66 health service areas covered by the Surveillance, Epidemiology, and End Results (SEER) program for women aged 65 and older at diagnosis. Incidence and survival data were derived from SEER, while breast cancer mortality data were from Vital Statistics data.


RESULTS
There was considerable variation in breast cancer survival among the 66 health service areas (chi2 = 202.7, p <.0001). There was also significant variation in incidence and mortality from breast cancer. In a partial correlation weighted for the size of the health service area, both incidence (r =.812) and percent 5-year survival (r = -.587) correlate with mortality. In a Poisson regression analysis, the combination of variation in incidence and variation in survival explains 90.9% of the variation in mortality.


CONCLUSIONS
There is considerable geographic variation in survival from breast cancer among older women, and this contributes to variation in breast cancer mortality. Geographic variations in breast cancer mortality should diminish as the quality of breast cancer care becomes more standardized.
Goodwin
James S
JS
Sealy Center on Aging, Department of Internal Medicine, The University of Texas Medical Branch, Galveston 77555-0460, USA. jsgoodwi@utmb.edu
Freeman
Jean L
JL
Mahnken
Jonathan D
JD
Freeman
Daniel H
DH
Nattinger
Ann B
AB
D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality* / Q000628:therapy*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D011787:Quality of Health Care; D012042:Registries; D018570:Risk Assessment; D018426:SEER Program; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology