Decrease of serum dipeptidylpeptidase activity in severe sepsis patients: relationship to procalcitonin.
A significant decrease of DPP IV activity has been found in patients with severe sepsis in relationship to the increase of procalcitonin. These findings might be explained by the high concentration of other substrates for DPP IV present in these patients. It can be hypothesized that this enzymatic decrease is bound to some changes in immunomodulation. Further studies will be necessary to elucidate the clinical importance of these findings.
Bergmann
Andreas
A
Brahms Diagnostica, Komturstrasse 19-20, D 12099, Berlin, Germany.
Bohuon
Claude
C
D002116:Calcitonin / Q000097:blood* / Q000378:metabolism*; D015740:Calcitonin Gene-Related Peptide; D018819:Dipeptidyl Peptidase 4 / Q000097:blood* / Q000378:metabolism*; D005470:Fluorometry; D006801:Humans; D011498:Protein Precursors / Q000097:blood* / Q000378:metabolism*; D018805:Sepsis / Q000097:blood / Q000201:enzymology*; D013223:Statistics as Topic
C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D018819:Dipeptidyl Peptidase 4; D015740:Calcitonin Gene-Related Peptide