title: Antimutagenic mechanisms of Phyllanthus orbicularis when hydrogen peroxide is tested using Salmonella assay.
abstract: Phyllanthus orbicularis is a medicinal plant, endemic to Cuba, whose aqueous extract has proven antiviral properties and antimutagenic activities against aromatic amines and hydrogen peroxide. In addition, this plant extract presents antioxidant activity. In this paper, using the Salmonella assay with the experimental approaches of co-incubation, pre- and post-treatments, it is shown that the P. orbicularis extract protects bacterial cells from oxidative damage and mutation by some intracellular mechanism, irrespective of its antioxidant activity.
authors.affiliation: Universitat Autònoma de Barcelona, Dpto de Genètica i de Microbiologia, Edifici C, 08193, Bellaterra, Barcelona, Spain.
authors.forename: Mirle
authors.initials: M
authors.lastname: Ferrer
authors.forename: Angel
authors.initials: A
authors.lastname: Sánchez-Lamar
authors.forename: Jorge
authors.initials: J
authors.lastname: Luís Fuentes
authors.forename: Jordi
authors.initials: J
authors.lastname: Barbé
authors.forename: Montserrat
authors.initials: M
authors.lastname: Llagostera
mesh_terms: D016587:Antimutagenic Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006861:Hydrogen Peroxide; D009152:Mutagenicity Tests; D009153:Mutagens; D010100:Oxygen / Q000378:metabolism; D029803:Phyllanthus / Q000378:metabolism*; D010936:Plant Extracts / Q000627:therapeutic use*; D012475:Salmonella / Q000378:metabolism*; D013997:Time Factors
chemical_list: D016587:Antimutagenic Agents; D009153:Mutagens; D010936:Plant Extracts; D006861:Hydrogen Peroxide; D010100:Oxygen