Activities of therapeutic agents and myristamidopropyl dimethylamine against Acanthamoeba isolates.
The activities of therapeutic agents and myristamidopropyl dimethylamine (MAPD) against Acanthamoeba strains recalcitrant to medical therapy were studied. MAPD minimum cysticidal concentrations were 6.25 to 25 microg/ml; 10 to 30 microg/ml gave at least a 3-log cyst kill after 6 h, and 50 and 100 microg/ml gave at least a 3-log cyst kill within 2 and 1 h, respectively.
Kilvington
Simon
S
Department of Microbiology and Immunology, University of Leicester, Leicester, United Kingdom. sk46@leicester.ac.uk
Hughes
Reanne
R
Byas
James
J
Dart
John
J
D000048:Acanthamoeba / Q000187:drug effects*; D015823:Acanthamoeba Keratitis / Q000382:microbiology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004351:Drug Resistance; D006801:Humans; D011437:Propylamines / Q000494:pharmacology*; D013997:Time Factors
D000981:Antiprotozoal Agents; D011437:Propylamines; C401661:myristamidopropyl dimethylamine