Urinary acidification and distal renal tubular acidosis.
Historically, renal tubular acidosis (RTA) has been classified on a clinical basis, without any reference to the underlying disorder. Here we review the normal mechanisms of renal acidification and we identify disorders of specific transporters (genetic, disease-related or drug-induced) that lead to the main categories of distal RTA. We also describe the approach to diagnosis and the current treatment of distal RTA.
Unwin
Robert J
RJ
Centre for Nephrology, Department of Physiology, Royal Free and University College Medical School, London, UK. robert.unwin@ucl.ac.uk
Shirley
David G
DG
Capasso
Giovambattista
G
D000141:Acidosis, Renal Tubular / Q000503:physiopathology / Q000628:therapy / Q000652:urine*; D000143:Acids / Q000378:metabolism / Q000652:urine*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007686:Kidney Tubules, Distal; D012016:Reference Values
D000143:Acids