title: A facile method for the stereoselective Horner-Wadsworth-Emmons reaction of aryl alkyl ketones.
abstract: Excellent Z or E selectivity was observed in the Horner-Wadsworth-Emmons (HWE) reactions of methyl bis(2,2,2-trifluoroethyl)phosphonoacetate or ethyl 2-fluoro-2-diethylphosphonoacetate with aryl alkyl ketones bearing substituents on an aromatic moiety employing Sn(OSO2CF3)2 in the presence of N-ethylpiperidine.
authors.affiliation: Faculty of Pharmaceutical Sciences, The University of Tokushima, Japan. ssano@ph2.tokushima-u.ac.jp
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sano
authors.forename: Kenji
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Nagao
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D007659:Ketones / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
chemical_list: D000473:Alkanes; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D007659:Ketones