title: Bioinformatics, functional genomics, and proteomics study of Bacillus sp.
abstract: The ability of bioinformatics to characterize genomic and proteomic sequences from bacteria Bacillus sp. for prediction of genes and proteins has been evaluated. Genomics coupling with proteomics, which is relied on integration of the significant advances recently achieved in two-dimensional (2-D) electrophoretic separation of proteins and mass spectrometry (MS), are now important and high throughput techniques for qualifying and analyzing gene and protein expression, discovering new gene or protein products, and understanding of gene and protein functions including post-genomic study. In addition, the bioinformatics of Bacillus sp. is embraced into many databases that will facilitate to rapidly search the information of Bacillus sp. in both genomics and proteomics. It is also possible to highlight sites for post-translational modifications based on the specific protein sequence motifs that play important roles in the structure, activity and compartmentalization of proteins. Moreover, the secreted proteins from Bacillus sp. are interesting and widely used in many applications especially biomedical applications that are the highly advantages for their potential therapeutic values.
authors.affiliation: Institute of Biological Chemistry, Academia Sinica, 128 Yen Chiu Yuan Rd., Sec II, Nankang, Taipei 11529, Taiwan.
authors.forename: Supachok
authors.initials: S
authors.lastname: Sinchaikul
authors.forename: Boonyaras
authors.initials: B
authors.lastname: Sookkheo
authors.forename: Supachai
authors.initials: S
authors.lastname: Topanuruk
authors.forename: Hsueh-Fen
authors.initials: HF
authors.lastname: Juan
authors.forename: Suree
authors.initials: S
authors.lastname: Phutrakul
authors.forename: Shui-Tein
authors.initials: ST
authors.lastname: Chen
mesh_terms: D001407:Bacillus / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D019295:Computational Biology; D015180:Electrophoresis, Gel, Two-Dimensional; D016680:Genome, Bacterial; D011499:Protein Processing, Post-Translational; D020543:Proteome
chemical_list: D001426:Bacterial Proteins; D020543:Proteome