Effect of subminimal inhibitory concentrations of gentamicin, penicillin, trimethoprim-sulfamethoxazole on adherence of uropathogenic Escherichia coli strains.
Evaluating the adherence factor of uropathogenic Escherichia coli is important for assessing the relative efficiency of antimicrobials when used at sub-minimal inhibitory concentration (sub-MICs). The microdilution method was used to determine the MICs of gentamicin, trimethoprim-sulfamethaxozole and penicillin. Then the efficacy of antimicrobial sub-MICs was determined by hemagglutination and adherence assays. Instead of showing nearly the same MICs, gentamicin had nearly twice the activity of trimethoprim-sulfamethaxozole. Gentamicin, as a "long acting" agent, can be accepted as being more effective than trimethoprim-sulfamethaxozole or penicillin, especially at sub-MICs, against adherence factors of uropathogenic E. coli, and can be used as monotherapy for urinary tract infections.
Baskin
H
H
Department of Microbiology and Clinical Microbiology, Dokuz Eylul University School of Medicine, Inciralti, Izmir, Turkey. huseyin.baskin@deu.edu.tr
Dogan
Y
Y
Hakki
Bahar I
BI
Yulug
N
N
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects* / Q000648:ultrastructure; D005839:Gentamicins / Q000494:pharmacology*; D006384:Hemagglutination / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*; D014552:Urinary Tract Infections / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination