Mechanically induced solid-state generation of phosphorus ylides and the solvent-free Wittig reaction.
We describe the nearly quantitative preparation of phosphorus ylides and the Wittig reaction occurring in the solid sate during high-energy mechanochemical processing. Initial insights into the details of the discovered chemical transformations indicate that high-energy mechanical processing supports the interaction of reacting centers by breaking crystallinity of the reactants and by providing mass transfer without a solvent.
Balema
Viktor P
VP
Ames Laboratory, Iowa State University, Ames, Iowa 50011-3020, USA. balema@ameslab.gov
Wiench
Jerzy W
JW
Pruski
Marek
M
Pecharsky
Vitalij K
VK