[Pharmacotherapeutic aspects of early postoperative period in patients with complicated gastroduodenal ulcer].
There were analyzed the immediate and remote results of treatment of 556 patients with complicated gastroduodenal ulcer, in whom radical operation and ulcer excision with various variants of medicinal correction in early postoperative period were performed. The best immediate result was achieved after performance of radical operation (vagotomy, thrifty gastric resection). But in 5-10 years after vagotomy performance the ulcer recurrency have occurred in 11.3% of observations. Excision of the ulcer morphological substratum in combination with antiulcer medicinal therapy in early postoperative period constitutes an alternative method of treatment of such patients. Important role of Helicobacter pylori in the ulcer complications occurrence was established, demanding application of antibacterial preparations. Of many schemes of antibacterial therapy existing preference should be given to combination of macrolides (clarythromycine) with nitroimidazole (tinidazole) and the proton pump inhibitors (pylobact) as most secure and quite effective one.
Korotkyĭ
V M
VM
Kolosovych
I V
IV
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000994:Antitrichomonal Agents / Q000627:therapeutic use*; D017291:Clarithromycin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D011184:Postoperative Period; D017494:Proton Pumps; D014011:Tinidazole / Q000627:therapeutic use*; D014628:Vagotomy / Q000379:methods*
D000900:Anti-Bacterial Agents; D000994:Antitrichomonal Agents; D017494:Proton Pumps; D014011:Tinidazole; D017291:Clarithromycin