Hypercalcemia and acute renal failure caused by production of parathyroid hormone-related protein from renal cell carcinoma.
A 69-year-old male patient was diagnosed with right-sided renal cell carcinoma and humoral hypercalcemia of malignancy caused by an excessive production of parathyroid hormone-related protein. The hypercalcemia led to acute tubular necrosis, so the patient had to be put on hemodialysis. The renal failure was accompanied by hyponatremic encephalopathy. Rapid correction of the hyponatremia might have initiated central pontine myelinolysis.
Ueno
Munehisa
M
Department of Urology, Keio University School of Medicine, Tokyo, Japan. camtmune@saitama-med.ac.jp
Ohigashi
Takashi
T
Nakashima
Jun
J
Nonaka
Shoichi
S
Deguchi
Nobuhiro
N
Murai
Masaru
M
D058186:Acute Kidney Injury / Q000209:etiology*; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000378:metabolism*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007680:Kidney Neoplasms / Q000150:complications / Q000378:metabolism*; D008297:Male; D044162:Parathyroid Hormone-Related Protein; D014176:Protein Biosynthesis
C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein