HLA-DRB1, DQB1, and DQA1 allele profile in Brazilian patients with type 1 diabetes mellitus.
HLA class II profile was evaluated in 64 Brazilian patients presenting with type 1 diabetes mellitus. Although the Brazilian population is highly miscegenated, HLA-DRB1*301, DRB1*04, DQB1*0302, and DQB1*0201 alleles, which are associated with the development of type 1 diabetes in several Western populations, were also overrepresented in Brazilian patients. In addition to HLA-DRB1*15 and DQB1*0602 alleles, DRB1*11, DRB1*13, and DQA1*01 allele groups were associated with protection against the development of type 1 diabetes in Brazilian patients.
Fernandes
A P M
AP
Department of General and Specialized Nursing, School of Nursing of Ribeirão Preto, University of São Paulo, 14 049-902, Ribeirão Preto, São Paulo, Brazil.
Louzada-Junior
P
P
Foss
M C
MC
Donadi
E A
EA
D000293:Adolescent; D000328:Adult; D000483:Alleles; D001938:Brazil; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D014644:Genetic Variation; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains