One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization.
Benzo[b]furan and indole analogues of some recently identified benzo[b]thiophene inhibitors of tubulin polymerization have been prepared, and their biological activity has been assessed. Several very potent analogues were identified.
Flynn
Bernard L
BL
Department of Chemistry, The Faculties, Australian National University, Canberra, ACT 0200, Australia. flynn@rsc.anu.edu.au
Hamel
Ernest
E
Jung
M Katherine
MK
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001704:Biopolymers; D002455:Cell Division / Q000187:drug effects; D003078:Colchicine / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011485:Protein Binding; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D001572:Benzofurans; D001704:Biopolymers; D007211:Indoles; D014404:Tubulin; D003078:Colchicine