title: The safety of high-dose vitamin E supplementation in healthy Japanese male adults.
abstract: We administered high-dose vitamin E to healthy adult male volunteers and assessed the safety of such supplementation. Fourteen volunteers received daily 1,200 IU of vitamin E (800 mg of D-alpha-tocopherol) for 28 d and eight controls were also enrolled. The volunteers treated with vitamin E showed no abnormalities during the study period. The alpha-tocopherol concentrations of plasma and platelets were markedly elevated by vitamin E treatment, but there were no significant differences in platelet aggregation, coagulation, and the clinical parameters between the two groups. In conclusion, a high dose of vitamin E for 28 d had no adverse effects in healthy men.
authors.affiliation: Department of Pediatrics, Osaka Medical College, Takatsuki, Japan. ped030@poh.osaka-med.ac.jp
authors.forename: Takao
authors.initials: T
authors.lastname: Morinobu
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Ban
authors.forename: Sosuke
authors.initials: S
authors.lastname: Yoshikawa
authors.forename: Takuji
authors.initials: T
authors.lastname: Murata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tamai
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000009:adverse effects*; D001772:Blood Cell Count; D001777:Blood Coagulation / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003324:Coronary Artery Disease / Q000517:prevention & control*; D019587:Dietary Supplements; D006801:Humans; D007564:Japan; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D013997:Time Factors; D014810:Vitamin E / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D002784:Cholesterol; D024502:alpha-Tocopherol