title: Dicobalt octacarbonyl promoted rearrangement of 4-isoxazolines to acylaziridines: dramatic rate acceleration with very high substrate tolerance.
abstract: [reaction: see text] Dicobalt octacarbonyl [Co(2)(CO)(8)] in acetonitrile at 75 degrees C triggers the cleavage of the N-O bond of 4-isoxazolines (1) to bring about the valence rearrangement to 2-acylaziridines (2). The isoxazolines were stable at 75 degrees C in the absence of the cobalt complex.
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Tsushima, Okayama, Japan 700-8530. sesaito@biotech.okayama-u.ac.jp
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kudoh
authors.forename: Juri
authors.initials: J
authors.lastname: Yoshida
authors.forename: Ayako
authors.initials: A
authors.lastname: Yasuhara
authors.forename: Shinobu
authors.initials: S
authors.lastname: Manabe
authors.forename: Seiki
authors.initials: S
authors.lastname: Saito