title: Discrimination between cases of duodenal ulcer and gastritis on the basis of putative virulence factors of Helicobacter pylori.
abstract: The BabA, cagA, and vacA statuses of 827 Helicobacter pylori isolates were used in logistic regression models to discriminate duodenal ulcer from gastritis. Only BabA was a candidate for a universal virulence factor, but the low c statistic value (0.581) indicates that none of these factors were helpful in predicting the clinical presentation.
authors.affiliation: Department of Medicine. Department of Health Services Research, Baylor College of MedicineVeterans Affairs Medical Center, Houston, Texas 77030, USA. yyamaoka@bcm.tmc.edu
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamaoka
authors.forename: Julianne
authors.initials: J
authors.lastname: Souchek
authors.forename: Stefan
authors.initials: S
authors.lastname: Odenbreit
authors.forename: Rainer
authors.initials: R
authors.lastname: Haas
authors.forename: Anna
authors.initials: A
authors.lastname: Arnqvist
authors.forename: Thomas
authors.initials: T
authors.lastname: Borén
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kodama
authors.forename: Michael S
authors.initials: MS
authors.lastname: Osato
authors.forename: Oscar
authors.initials: O
authors.lastname: Gutierrez
authors.forename: Jong G
authors.initials: JG
authors.lastname: Kim
authors.forename: David Y
authors.initials: DY
authors.lastname: Graham
mesh_terms: D018829:Adhesins, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D004381:Duodenal Ulcer / Q000175:diagnosis* / Q000382:microbiology*; D005756:Gastritis / Q000175:diagnosis* / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D016015:Logistic Models; D014774:Virulence
chemical_list: D018829:Adhesins, Bacterial; D000942:Antigens, Bacterial; C400429:BabA protein, Helicobacter pylori; D001426:Bacterial Proteins; D002352:Carrier Proteins; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori