[Glutamate decarboxylase activity and GABA binding by synaptic membranes of brain structure under stress in intact rats and rats with hormonal blockade of the hypothalamo-hypophyseal-adrenal cortex system].
Under the inhibition of hypothalamo-pituitary-adrenal system function, as a result of prolonged hydrocortisone administration, the normal neurochemical reaction to stress, i.e. stimulating the formation of GABA (mediator that is basic among responsible ones for the realization of stress-limiting brain function) was absent. In the medulla under such conditions an increase in the degree of GABA reception processes activation of comparing with the intact stressed rats was revealed and in the hippocamp of their changes was directivity reverse.
Myshunina
T M
TM
Komisarenko Institute of Endocrinology and Metabolism, AMS of Ukraine, Kyiv.
Kononenko
V Ia
VIa
D000302:Adrenal Cortex / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System; D008297:Male; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000201:enzymology*; D013570:Synaptic Membranes / Q000201:enzymology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase