Aberrant expression of cyclin A in laryngeal squamous cell carcinoma.
The expression of cyclin A protein was retrospectively investigated in 102 patients with human laryngeal squamous cell carcinoma (LSCC) by using immunohistochemistry. Out of 102 tumors, 41 (40.2%) exhibited positive-staining in cancer cells with this antibody. No association between cyclin A overexpression and the patients' clinicopathological parameters was found. However, cyclin A overexpression was significantly associated with CDK2 and PCNA expression (p = 0.01 and p = 0.001, respectively). Kaplan-Meier analysis showed that patients with overexpression of cyclin A were associated with poor disease-free survival (p = 0.046), but it was not associated with overall survival (p = 0.106). Additionally, patients with both lymph node metastasis and cyclin A overexpression were significantly associated with worse disease-free survival (p < 0.0001). The multivariate analysis showed that tumor size, lymph node metastasis and cyclin A overexpression are significantly independent prognostic factors of disease-free survival. These findings suggest that cyclin A overexpression is associated with recurrence of LSCC.
Dong
Youyi
Y
Department of Physiology, Kagawa Medical University, Kita-gun, Japan.
Sui
Li
L
Watanabe
Yasuo
Y
Sugimoto
Katsuyoshi
K
Tokuda
Masaaki
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D042846:CDC2-CDC28 Kinases; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002455:Cell Division / Q000502:physiology; D019925:Cyclin A / Q000096:biosynthesis*; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis; D012189:Retrospective Studies; D015996:Survival Rate
D019925:Cyclin A; D018809:Proliferating Cell Nuclear Antigen; D017346:Protein Serine-Threonine Kinases; D042846:CDC2-CDC28 Kinases; C495894:CDK2 protein, human; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases