title: Development of tripeptidyl farnesyltransferase inhibitors.
abstract: The first example of tripeptide inhibitors of farnesyltransferase with sub-micromolar inhibition activity was developed based on the fact that CVFM is not a substrate for farnesyltransferase.
authors.affiliation: Center for Molecular Design and Synthesis, Department of Chemistry and School of Molecular Science(BK21), Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea. leehy@kaist.ac.kr
authors.forename: Hee-Yoon
authors.initials: HY
authors.lastname: Lee
authors.forename: Jeong-Hun
authors.initials: JH
authors.lastname: Sohn
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000595:Amino Acid Sequence; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051231:Farnesyltranstransferase; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D009842:Oligopeptides; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase