Iodine-123-metaiodobenzylguanidine scintigraphy of total cardiac adrenergic denervation in Brugada syndrome.
A 22-year-old Japanese man with Brugada syndrome was resuscitated from cardiopulmonary arrest. In addition to the electrocardiographic evidence of the syndrome and the absence of apparent structural heart disease, no accumulation of iodine-123-metaiodobenzylguanidine (MIBG) was found anywhere throughout the heart. Thallium-201 (Tl) single photon emission computed tomography (SPECT) distribution showed no significant decrease in its uptake. To our knowledge, this is the first report that has demonstrated a homogeneous absence of cardiac accumulation of MIBG in Brugada syndrome.
Oyama
Naotsugu
N
Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Oyama
Noriko
N
Yokoshiki
Hisashi
H
Satoh
Katsuhiko
K
Katoh
Noriyoshi
N
Hayashi
Toshiyuki
T
Miyasaka
Kazuo
K
Kitabatake
Akira
A
D019797:3-Iodobenzylguanidine; D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000000981:diagnostic imaging*; D002037:Bundle-Branch Block / Q000000981:diagnostic imaging*; D004562:Electrocardiography; D006321:Heart / Q000000981:diagnostic imaging* / Q000294:innervation*; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D019275:Radiopharmaceuticals; D013577:Syndrome; D015899:Tomography, Emission-Computed, Single-Photon; D014693:Ventricular Fibrillation / Q000175:diagnosis*
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine