Population genetics in minority children with type 2 diabetes mellitus.
Non-insulin dependent (type 2) diabetes mellitus (DM) is a rapidly emerging health threat in minority populations in the United States, with the African-American, Hispanic, and Native American populations at greatest risk. Clearly, environmental factors play a role in this disorder, but the ethnic predilection suggests a significant genetic component. Type 2 DM is a condition not well understood on a genetic basis. Familial clustering and ethnic variation have been documented. The populations of Africans living in diverse environments provide a unique opportunity to study type 2 DM as the mechanism is becoming more clear.
Wallerstein
Robert
R
Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn 11203, USA. rwallerstein@humed.com
D044383:Black People / Q000235:genetics; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D004777:Environment; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D007198:Indians, North American / Q000235:genetics; D008913:Minority Groups; D014481:United States / Q000453:epidemiology; D001741:Black or African American