title: [Anesthesia induction with sevoflurane in adult patients with predictive signs of difficult intubation].
abstract: OBJECTIVE
  This work was carried out to study induction with sevoflurane in adult patients with predictive signs of difficult intubation.
  
  
  METHODS
  Randomised prospective study.
  
  
  METHODS
  The study had two parts. Part I: 15 patients without predictive signs of difficult intubation but with a cervical collar. Eight patients were anaesthetised with propofol 3 mg.kg-1 and fentanyl 2 micrograms.kg-1, seven with sevoflurane 8%. Part II: 20 patients with predictive signs of difficult intubation anaesthetised with sevoflurane 8%.
  
  
  RESULTS
  In part I, all patients were intubated, the time for intubation was longer with sevoflurane, 6 vs 4 min. They were apneic only in the propofol group. After intubation, 7 cases of coughing (4 severe) occurred in the propofol group and 3 moderate coughing in the sevoflurane group. In part II, one patient experienced considerable agitation after oral airway insertion and was excluded. Other patients were intubated with sevoflurane. Seven patients were intubated with a bougie, three patients through an intubating LMA and one patient with a rigid bronchoscope. The other patients were intubated with a Macintosh blade. The mean time for intubation was 10 +/- 7 min and end tidal sevoflurane concentration after intubation was 4 +/- 0.6%. After intubation, 7 cases of coughing (3 severe) occurred but no desaturation < 95%. No significant haemodynamic variations occurred.
  
  
  CONCLUSIONS
  Induction with sevoflurane 8% allowed tracheal intubation without major incidents. All patients breathed spontaneously. Sevoflurane can be recommended for induction in cases of predictive difficult intubation.
authors.affiliation: Département d'anesthésie-réanimation IV, hôpital Pellegrin-Enfants, 33076 Bordeaux, France. anne-marie.cros@chu-bordeaux.fr
authors.forename: A M
authors.initials: AM
authors.lastname: Cros
authors.forename: F
authors.initials: F
authors.lastname: Chopin
authors.forename: C
authors.initials: C
authors.lastname: Lopez
authors.forename: C
authors.initials: C
authors.lastname: Kays
mesh_terms: D000328:Adult; D000777:Anesthetics / Q000008:administration & dosage; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D000077149:Sevoflurane
chemical_list: D000777:Anesthetics; D008738:Methyl Ethers; D000077149:Sevoflurane; D005283:Fentanyl