RhoGAP: the next big thing for small mice?
The size of an organism is determined by the number and size of its constituent cells. The insulin/IGF-1 signaling systems have been long recognized to play a critical role in the determination of body size. Now the generation of mice deficient for a RhoGAP suggests that this small G protein might also regulate the growth of animals.
Birnbaum
Morris J
MJ
Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA.
D000818:Animals; D001824:Body Constitution / Q000235:genetics / Q000502:physiology*; D048429:Cell Size / Q000235:genetics / Q000502:physiology; D004268:DNA-Binding Proteins; D020690:GTPase-Activating Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000502:physiology; D007328:Insulin / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology; D012097:Repressor Proteins; D015398:Signal Transduction
C513041:Arhgap35 protein, mouse; C513042:Arhgap5 protein, mouse; D004268:DNA-Binding Proteins; D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; D007328:Insulin; D009687:Nuclear Proteins; D012097:Repressor Proteins; C085379:rho GTPase-activating protein; D007334:Insulin-Like Growth Factor I