Positron emission tomography (PET) evaluation of abdominal aortic aneurysm (AAA).
BACKGROUND
aneurysmal disease is associated with an inflammatory cell infiltrate and enzymatic degradation of the vessel wall.


OBJECTIVE
to detect increased metabolic activity in abdominal aortic aneurysms (AAA) by means of positron emission tomography (PET-imaging).


METHODS
twenty-six patients with AAA underwent PET-imaging.


RESULTS
in ten patients, PET-imaging revealed increased fluoro-deoxy-glucose (18-FDG) uptake at the level of the aneurysm. Patients with positive PET-imaging had one or more of the following elements in their clinical history: history of recent non-aortic surgery (n = 4), a painful inflammatory aortic aneurysm (n = 2), moderate low back pain (n = 2), rapid (> 2;5 mm in 6 months) expansion (n = 4), discovery by PET-scan of a previously undiagnosed lung cancer (n = 3) or parotid tumour (n = 1). Five patients with a positive PET scan required urgent surgery within two to 30 days. Among the 16 patients with negative PET-imaging of their aneurysm, only one had recent non-aortic surgery, none of them required urgent surgery, only two had a rapidly expanding AAA, and in only one patient, PET-imaging revealed an unknown lung cancer.


CONCLUSIONS
these data suggest a possible association between increased 18-FDG uptake and AAA expansion and rupture.
Sakalihasan
N
N
Department of Cardiovascular Surgery, University Hospital of Liège, CHU Sart-Tilman, 4000 Liege, Belgium. nsaka@chu.ulg.ac.be
Van Damme
H
H
Gomez
P
P
Rigo
P
P
Lapiere
C M
CM
Nusgens
B
B
Limet
R
R
D000368:Aged; D000369:Aged, 80 and over; D001012:Aorta, Abdominal / Q000378:metabolism / Q000601:surgery; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000601:surgery; D001019:Aortic Rupture / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000601:surgery; D001416:Back Pain / Q000209:etiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007089:Image Enhancement; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012720:Severity of Illness Index; D013223:Statistics as Topic; D014055:Tomography, Emission-Computed; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures
D019788:Fluorodeoxyglucose F18