title: Enhanced radical-scavenging activity of a planar catechin analogue.
abstract: A catechin analogue in which the geometry was constrained to be planar was synthesized. The planar catechin showed excellent radical-scavenging ability, comparable to that of quercetin, and efficient protection against DNA strand breakage induced by the Fenton reaction.
authors.affiliation: Division of Organic Chemistry, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501, Japan. fukuhara@nihs.go.jp
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fukuhara
authors.forename: Ikuo
authors.initials: I
authors.lastname: Nakanishi
authors.forename: Hisao
authors.initials: H
authors.lastname: Kansui
authors.forename: Etsuko
authors.initials: E
authors.lastname: Sugiyama
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kimura
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Shimada
authors.forename: Shiro
authors.initials: S
authors.lastname: Urano
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Naoki
authors.initials: N
authors.lastname: Miyata
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004249:DNA Damage; D004278:DNA, Superhelical / Q000737:chemistry / Q000187:drug effects; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000737:chemistry; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D004278:DNA, Superhelical; D016166:Free Radical Scavengers; D017665:Hydroxyl Radical; D002392:Catechin; D011794:Quercetin