title: Esophageal squamous metaplasia: nudging the esophageal carcinoma morphogenetic paradigm.
abstract: The concept regarding esophageal squamous metaplasia, its existence, origin and the role it plays in the etiology of esophageal carcinoma, needs some urgent attention. Explanations regarding the presence of metaplastic squamous epithelial cells on esophageal smears, from asymptomatic high-risk patients undergoing screening for esophageal carcinoma, are difficult to find. The presence of squamous metaplastic cells on smears from the esophagus collected by us since 1983, from rural Transkei populations, is a regular finding and warrants some discussion. Cellular material from the esophageal lumen is collected with a gelatine encapsulated sponge brush for cytological evaluation. Each full-length, 'blind' sampling procedure produces a mixture of single cells, sheets, small groups as well as microbiopsies. Some very well preserved and excellent examples of esophageal epithelium undergoing or in a state of squamous metaplasia are a regular find.
authors.affiliation: PROMEC Unit, Medical Research Council, Tygerberg, South Africa. francois.venter@mrc.ac.za
authors.forename: F S
authors.initials: FS
authors.lastname: Venter
authors.forename: G
authors.initials: G
authors.lastname: Learmonth
mesh_terms: D044383:Black People; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002584:Cervix Uteri / Q000473:pathology; D018450:Disease Progression; D004848:Epithelium / Q000473:pathology; D004938:Esophageal Neoplasms / Q000209:etiology / Q000473:pathology*; D004947:Esophagus / Q000473:pathology*; D005088:Exocrine Glands / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D009928:Organ Specificity; D011230:Precancerous Conditions / Q000473:pathology*; D012424:Rural Population; D013019:South Africa