title: Inheritance of hypoadrenocorticism in bearded collies.
abstract: OBJECTIVE
  To assess heritability and mode of inheritance for hypoadrenocorticism in Bearded Collies.
  
  
  METHODS
  635 Bearded Collies.
  
  
  METHODS
  Dogs were classified as affected by hypoadrenocorticism or unaffected. Phenotypic and pedigree data were analyzed. Heritability was estimated by use of Bayesian statistical methods. Regressive logistic models for complex segregation analyses were used to characterize mode of inheritance.
  
  
  RESULTS
  Hypoadrenocorticism was diagnosed in 60 (9.4%) dogs. Heritability of hypoadrenocorticism was estimated to be 0.76 with both sexes affected with equal probability. Evaluation of the pedigrees did not support a Mendelian autosomal dominant mode of inheritance. Evidence from the complex segregation analysis for a single locus of large effect on hypoadrenocorticism was not convincing.
  
  
  CONCLUSIONS
  Hypoadrenocorticism in Bearded Collies is highly heritable. Although a precise genetic mechanism responsible for inheritance of the disorder remains undetermined, breeding decisions must include consideration of the genetic likelihood of passing on this deleterious disorder to offspring of affected dams and sires.
authors.affiliation: Department of Animal Science, College of Agricultural and Environmental Sciences, University of California, Davis 95616, USA.
authors.forename: Anita M
authors.initials: AM
authors.lastname: Oberbauer
authors.forename: K S
authors.initials: KS
authors.lastname: Benemann
authors.forename: Janelle M
authors.initials: JM
authors.lastname: Belanger
authors.forename: D R
authors.initials: DR
authors.lastname: Wagner
authors.forename: J H
authors.initials: JH
authors.lastname: Ward
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Famula
mesh_terms: D000309:Adrenal Insufficiency / Q000235:genetics / Q000662:veterinary*; D000818:Animals; D001499:Bayes Theorem; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D016015:Logistic Models; D008297:Male; D010375:Pedigree