title: Preferential uptake of zinc, manganese, and rubidium in rat brain tumor.
abstract: The search for radionuclides that can be an index of viability in proliferating cells is important for nuclear medicine diagnosis of brain tumors. On the basis of the finding that 65Zn is preferentially taken up in rat brain tumors, the uptake of various radionuclides was examined in rat brain tumor by using the multitracer technique. Male Fisher rats were intrahippocampally injected with C6 glioma cells. Fourteen days after implantation, the radioactive multitracer solution was injected into the tail vein of tumor-bearing rats. One hour after intravenous injection, the uptake of 65Zn, 83Rb and 54Mn was relatively high in C6 glioma of 15 radionuclides detected, and was much higher than in other brain regions and in the blood. It is likely that rubidium and manganese, in addition to zinc, are preferentially taken up by tumors in the brain.
authors.affiliation: Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
authors.forename: Haruna
authors.initials: H
authors.lastname: Tamano
authors.forename: Shuichi
authors.initials: S
authors.lastname: Enomoto
authors.forename: Naoto
authors.initials: N
authors.lastname: Oku
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeda
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D005910:Glioma / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008345:Manganese / Q000493:pharmacokinetics*; D009368:Neoplasm Transplantation; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D011916:Rats, Inbred F344; D015203:Reproducibility of Results; D012414:Rubidium Radioisotopes / Q000493:pharmacokinetics*; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured; D015037:Zinc Radioisotopes / Q000493:pharmacokinetics*
chemical_list: D019275:Radiopharmaceuticals; D012414:Rubidium Radioisotopes; D015037:Zinc Radioisotopes; D008345:Manganese