Remission of West syndrome associated with valproate hepatotoxicity.
A 6-month-old girl developed West syndrome and it remitted in association with valproate-induced hepatic dysfunction. Plasma -alanine elevated after valproate hepatotoxicity, which seemed to be a possible cause of remission. The patient has been seizure-free with normal electroencephalogram for 12 months without any anticonvulsants. Her developmental milestones were within normal limits at the age of 18 months.
Go
Tohshin
T
Department of Pediatrics, Otsu Red Cross Hospital, 1-1-35, Nagara, Japan. masumigo@mbox.kyoto-inet.or.jp
D000927:Anticonvulsants / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000097:blood; D013036:Spasms, Infantile / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D014635:Valproic Acid / Q000009:adverse effects*; D015091:beta-Alanine / Q000097:blood
D000927:Anticonvulsants; D015091:beta-Alanine; D014635:Valproic Acid