Enhanced selection for MHC diversity in social tuco-tucos.
To explore the effects of behavior and demography on balancing selection at major histocompatibility complex (MHC) loci, we examined allelic diversity at exon 2 of the MHC class II DQbeta locus in a social and a solitary species of tuco-tuco (Rodentia: Ctenomyidae: Ctenomys), both of which occur in the same valley in southwestern Argentina. By comparing patterns of diversity at this MHC gene to the diversity evident at fifteen microsatellite loci, we demonstrate that balancing selection at the DQbeta locus is enhanced in the social species compared to its solitary congener. These findings have intriguing implications for the role of behavioral and demographic parameters in maintaining diversity at MHC loci.
Hambuch
Tina M
TM
Museum of Vertebrate Zoology and Department of Integrative Biology, University of California, Berkeley 94720, USA. thambuch@cdc.gov
Lacey
Eileen A
EA
D000818:Animals; D001118:Argentina; D005091:Exons; D005802:Genes, MHC Class II / Q000235:genetics*; D014644:Genetic Variation; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D018895:Microsatellite Repeats; D017433:Protein Structure, Secondary; D012377:Rodentia / Q000235:genetics* / Q000276:immunology; D012641:Selection, Genetic
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C057615:HLA-DQbeta antigen