title: Luteal phase support using either Crinone 8% or Utrogest: results of a prospective, randomized study.
abstract: The Crinone 8% preparation makes it possible to administer natural progesterone (90 mg) vaginally once daily for luteal phase support (LPS). Until now, no prospective, randomized studies have directly compared this new preparation with widely used Utrogest capsules, which were originally designed for oral administration but are used routinely as a vaginal preparation. A prospective, randomized study investigated 126 patients undergoing cycles of in vitro fertilization (IVF) and IVF/intracytoplasmic sperm injection (ICSI). Patients received either Crinone 8% (n = 73) vaginally once daily or two Utrogest capsules (n=53) vaginally three times daily (600 mg). Clinical pregnancy rates were comparable (28.8 versus 18.9%), as were clinical abortion rates until 12 weeks of gestation (14.3 versus 10.0%) and clinical ongoing pregnancy rates (24.7 versus 17.0%) in the Crinone 8% and Utrogest groups, respectively. Forty-seven non-pregnant patients were randomly selected to answer questions regarding comfort during LPS. Crinone 8% had a clear advantage over Utrogest as it resulted in less vaginal discharge (P < 0.01) and fewer application difficulties (P<0.05). Twenty patients familiar with the alternative preparation from a previous cycle also noted that Crinone 8% was easier to apply (P < 0.01) and less time consuming (P < 0.05) to use than Utrogest.
authors.affiliation: Department of Gynecology and Obstetrics, Medical University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. ludwig_m@online.de
authors.forename: M
authors.initials: M
authors.lastname: Ludwig
authors.forename: P
authors.initials: P
authors.lastname: Schwartz
authors.forename: B
authors.initials: B
authors.lastname: Babahan
authors.forename: A
authors.initials: A
authors.lastname: Katalinic
authors.forename: J M
authors.initials: JM
authors.lastname: Weiss
authors.forename: R
authors.initials: R
authors.lastname: Felberbaum
authors.forename: S
authors.initials: S
authors.lastname: Al-Hasani
authors.forename: K
authors.initials: K
authors.lastname: Diedrich
mesh_terms: D000022:Abortion, Spontaneous; D000282:Administration, Intravaginal; D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008183:Luteal Phase; D017060:Patient Satisfaction; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic; D011795:Surveys and Questionnaires
chemical_list: C400424:Crinone; D011374:Progesterone