title: The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12.
abstract: Members of the ADAM superfamily of metalloprotease genes are involved in a number of biological processes, including fertilization, neurogenesis, muscle development, and the immune response. These proteins have been classified into several groups. The prototypic ADAM family is comprised of a pro-domain, a metalloprotease domain, a disintegrin domain, a cysteine-rich region, a transmembrane domain, and a variable cytoplasmic tail. We recently identified a novel member of this superfamily, ADAMDEC1 (decysin). Due to the partial lack of a disintegrin domain and the total lack of a cysteine-rich domain, this protein has been placed in a novel subclass of the ADAM gene family. We have investigated the gene structure of the human and mouse ADAMDEC1 and have revealed a metalloprotease gene cluster on human Chromosome 8p12 comprising ADAMDEC1, ADAM7, and ADAM28. Our results suggest that ADAMDEC1 has arisen by partial gene duplication from an ancestral gene at this locus and has acquired a novel function. ADAMDEC1 is expressed in the immune system, by dendritic cells and macrophages. The relatedness of ADAMDEC1, ADAM7, and ADAM28 suggests that these proteases share a similar function.
authors.affiliation: Schering-Plough, Laboratory for Immunological Research, 27 chemin des peupliers, BP11, 69571 Dardilly cedex, France.
authors.forename: Elizabeth E M
authors.initials: EE
authors.lastname: Bates
authors.forename: Wolf H
authors.initials: WH
authors.lastname: Fridman
authors.forename: Chris G F
authors.initials: CG
authors.lastname: Mueller
mesh_terms: D051722:ADAM Proteins; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002898:Chromosomes, Human, Pair 8; D019143:Evolution, Molecular; D018628:Gene Dosage; D020440:Gene Duplication; D006801:Humans; D008253:Macaca mulatta; D008562:Membrane Glycoproteins / Q000235:genetics; D008666:Metalloendopeptidases / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D005810:Multigene Family; D011401:Promoter Regions, Genetic; D016415:Sequence Alignment
chemical_list: D008562:Membrane Glycoproteins; D051722:ADAM Proteins; C410224:ADAM28 protein, human; C438783:ADAM7 protein, human; C472807:Adam32 protein, mouse; D008666:Metalloendopeptidases; C108169:decysin