title: Inoculation with Bartonella henselae followed by feline herpesvirus 1 fails to activate ocular toxoplasmosis in chronically infected cats.
abstract: Infection by Toxoplasma gondii is very common in cats although most remain disease free. The factors that trigger development of uveitis in some cats infected with T gondii have not been elucidated, but infection by more than one organism may be contributory. In this study, cats chronically infected with T gondii were inoculated with Bartonella henselae followed by FHV-1 to test the hypothesis that immune stimulation by multiple infections will reactivate ocular toxoplasmosis. Anterior uveitis and chorioretinitis were not detected in the cats with chronic T gondii infection thus allowing rejection of the hypothesis using this experimental design.
authors.affiliation: Department of Clinical Sciences, Colorado State University, 300 W. Drake, Fort Collins, Colorado, 80523-1620, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: Powell
authors.forename: D L
authors.initials: DL
authors.lastname: Kordick
authors.forename: M R
authors.initials: MR
authors.lastname: Lappin
mesh_terms: D000818:Animals; D018416:Bartonella henselae / Q000472:pathogenicity*; D002371:Cat Diseases / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology / Q000821:virology; D002415:Cats; D002908:Chronic Disease; D014122:Toxoplasma / Q000472:pathogenicity; D014124:Toxoplasmosis, Animal / Q000276:immunology*; D014126:Toxoplasmosis, Ocular / Q000276:immunology / Q000662:veterinary*; D018140:Varicellovirus / Q000472:pathogenicity*