title: Structure, properties and in vitro cytotoxic activity of hexakis(2-cyanoethyl)ditin(III).
abstract: The structure of the tin(III) complex [Sn(2)(CH(2)CH(2)CN)(6)] has been determined. There are two independent molecules in the crystal, both adopt distorted eclipsed conformation. The molecular and electronic structures of this compound have been studied both at the semiempirical level and with the use of non-empirical ab initio methods. The calculated Sn-Sn distances agree well with those found crystallographically. The results of calculations showed that the eclipsed conformation of complex is more stable as compared with staggered conformation. The compound show modest cytotoxic activity against A549 and HSMC cells.
authors.affiliation: Faculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wrocław, Poland. pruchnik@wchuwr.chem.uni.wroc.pl
authors.forename: Florian P
authors.initials: FP
authors.lastname: Pruchnik
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Bańbuła
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Ciunik
authors.forename: Henryk
authors.initials: H
authors.lastname: Chojnacki
authors.forename: Barbara
authors.initials: B
authors.lastname: Skop
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Latocha
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Wilczok
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D018360:Crystallography, X-Ray; D004563:Electrochemistry; D006801:Humans; D015394:Molecular Structure; D009947:Organotin Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009947:Organotin Compounds; C460340:hexakis(2-cyanoethyl)ditin(III)