title: Growth dynamics of meningiomas in patients with multiple sclerosis treated with interferon: report of two cases.
abstract: BACKGROUND
  Although multiple sclerosis (MS) is a common disease of the central nervous system, the association of intraparenchymal tumour has been rarely reported and the potential relationship between intracranial meningioma and MS has not been seriously analysed. This report addresses the association of multiple sclerosis and intracranial meningioma and discusses the effect of interferon treatment on tumour progression.
  
  
  METHODS
  We report two cases with multiple sclerosis, who developed meningioma four and twenty years after the diagnosis of MS was made. Neither patient had a history of meningioma initially and both were being treated interferon when the meningioma was progressed.
  
  
  RESULTS
  Histological examination of two cases revealed meningothelial meningioma. The first patient's KI67 level was 2.5% and was positive for the progesterone and estrogen receptor. Chromosomal analysis showed some abnormalities. In the second case, mild atypical change by presence of nuclear enlargement and rare mitotic figures were noted and PCNA, KI67 levels were less than 2%.
  
  
  CONCLUSIONS
  We reported the association of multiple sclerosis and intracranial meningioma and observed the progression of the meningiomas during interferon treatment. Although, we cannot exclude the coincidence between the two diseases we discussed suspicious relationship between the interferon treatment and the tumour progression.
authors.affiliation: Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
authors.forename: F
authors.initials: F
authors.lastname: Batay
authors.forename: O
authors.initials: O
authors.lastname: Al-Mefty
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects* / Q000627:therapeutic use*; D018450:Disease Progression; D005260:Female; D006801:Humans; D000068556:Interferon beta-1a; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000009:adverse effects* / Q000627:therapeutic use*; D008297:Male; D008577:Meningeal Neoplasms / Q000209:etiology / Q000473:pathology*; D008579:Meningioma / Q000209:etiology / Q000473:pathology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000276:Adjuvants, Immunologic; D000068576:Interferon beta-1b; D016899:Interferon-beta; D000068556:Interferon beta-1a