[Study on voltammetric behaviour of clozapine and its single-sweep oscillopolarography].
A sensitive reduction peak of clozapine is obtained by single-sweep oscillopolarography in 0.1 mol.L-1 H2SO4 solution. The peak potential is -0.95 V (vs. SCE). The peak current is directly proportional to the concentration of clozapine with a detection limit of 2.0 x 10(-8) mol.L-1. The voltammetric behaviour of clozapine and its mechanism of electrode reaction have been studied by linear-sweep and cyclic voltammetry and pulse polarography etc. The reduction process is irreversible with adsorptive characteristics. The number of electrons transferred n is 2. The electron transfer coefficient alpha is 0.62. Its behaviour obeys Langmuir adsorption isotherm. The adsorption coefficient beta is 1.91 x 10(6) L.mol-1. The energy of adsorption delta G0 = -35.83 kJ.mol-1. The method has been applied to the determination of clozepine in tablet and urine.
Hu
J
J
Department of Chemistry, Beijing Normal University, Beijing 100875.
Li
Q
Q
Yin
D
D
Miao
H
H
Lu
Y
Y
D014150:Antipsychotic Agents / Q000032:analysis / Q000652:urine; D003024:Clozapine / Q000032:analysis* / Q000652:urine; D006801:Humans; D011048:Polarography / Q000379:methods
D014150:Antipsychotic Agents; D003024:Clozapine