Cell fate determination from stem cells.
In the adult, tissue-specific stem cells are thought to be responsible for the replacement of differentiated cells within continuously regenerating tissues, such as the liver, skin, and blood system. In this review, we will consider the factors that influence stem cell fate, taking as a primary example the cell fate determination of hematopoietic stem cells.
Wagers
A J
AJ
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Christensen
J L
JL
Weissman
I L
IL
D000328:Adult; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D012038:Regeneration / Q000502:physiology*