title: Prevention by polyhydroxysteroids and saponins of Asterina pectinifera of the desquamation of stratum corneum cells.
abstract: Two polyhydroxysteroids and three steroidal saponins (pectiniosides A, B and C) were isolated as bioactive substances from Asterina pectinifera. These compounds inhibited the release of guinea-pig skin stratum corneum cells by 48-67% (control, 0%) at 2 mg/ml. It is suggested that the bioactivity of these compounds is connected with the remedial and preventive effects of an aqueous extract of A. pectinifera on rough human skin.
authors.affiliation: Department of Ocean Sciences, Tokyo University of Fisheries, Japan.
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Ukai
authors.forename: Atsufumi
authors.initials: A
authors.lastname: Iwanaga
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagai
authors.forename: Michio
authors.initials: M
authors.lastname: Namikoshi
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D004447:Echinodermata; D006168:Guinea Pigs; D006801:Humans; D006914:Hydroxysteroids / Q000627:therapeutic use*; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry / Q000494:pharmacology; D012503:Saponins / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D015595:Skin Aging / Q000187:drug effects*; D012871:Skin Diseases / Q000517:prevention & control*
chemical_list: D006914:Hydroxysteroids; D009844:Oligosaccharides; D012503:Saponins