HIV-1 subtypes in Yugoslavia.
To gain insight concerning the genetic diversity of HIV-1 viruses associated with the HIV-1 epidemic in Yugoslavia, 45 specimens from HIV-1-infected individuals were classified into subtypes by sequence-based phylogenetic analysis of the polymerase (pol) region of the viral genome. Forty-one of 45 specimens (91.2%) were identified as pol subtype B, 2 of 45 as subtype C (4.4%), 1 of 45 as CRF01_AE (2.2%), and 1 as CRF02_AG recombinant (2.2%). Nucleotide divergence among subtype B sequences was 4.8%. Results of this study show that among HIV-1-infected patients in Yugoslavia subtype B predominates (91.5%), whereas non-B subtypes are present at a low percentage, mostly related to travel abroad.
Stanojevic
Maja
M
Institute of Microbiology and Immunology, Medical School, University of Belgrade, DrSubotica 1, 11000 Belgrade, Yugoslavia. nasta@eunet.yu
Papa
Anna
A
Papadimitriou
Evagelia
E
Zerjav
Sonja
S
Jevtovic
Djordje
D
Salemovic
Dubravka
D
Jovanovic
Tanja
T
Antoniadis
Antonis
A
D000328:Adult; D001483:Base Sequence; D005260:Female; D015684:Gene Products, pol / Q000235:genetics*; D014644:Genetic Variation; D015658:HIV Infections / Q000821:virology; D015497:HIV-1 / Q000145:classification* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic; D015022:Yugoslavia
D015684:Gene Products, pol