title: Iodopropynyl butylcarbamate.
abstract: Iodopropynyl butylcarbamate (IPBC) is an internationally recognized chemical that has been used for years because of its wide field of application. Initially used as a water-based paint and wood preservative and then in metalworking fluids, its role has expanded into the more recent uses in cosmetic products. The need for a potent, broad-spectrum, and safe preservative system in cosmetics allowed for the discovery of several combinations of IPBC effective against a wide variety of organisms. Although IPBC has claimed to be safe when used at concentrations less than 0.1%, the introduction of IPBC into cosmetics has led to several reports labeling IPBC as a potential new contact allergen. As the use of this seemingly safe preservative becomes vast, an increased number of cases of IPBC-induced contact allergy is likely.
authors.affiliation: Department of Dermatology, Penn State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, PA, USA.
authors.forename: Sonia
authors.initials: S
authors.lastname: Badreshia
authors.forename: James G
authors.initials: JG
authors.lastname: Marks
mesh_terms: D000485:Allergens / Q000009:adverse effects*; D002219:Carbamates / Q000009:adverse effects*; D003358:Cosmetics / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D006801:Humans; D010328:Patch Tests / Q000592:standards; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*
chemical_list: D000485:Allergens; D002219:Carbamates; D003358:Cosmetics; D011310:Preservatives, Pharmaceutical; C106572:3-iodo-2-propynylbutylcarbamate