5-Bromo-2'-deoxyuridine efficiently suppresses division potential of the yeast Saccharomyces cerevisiae.
We established a thymidine-auxotrophic strain of the yeast Saccharomyces cerevisiae to examine biological effects of thymidine analogues. 5-Bromo-2'-deoxyuridine efficiently suppressed the division potential of yeast showing morphology similar to senescent cells.
Fujii
Michihiko
M
Division of Biochemistry, Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City University, Yokohama, Japan.
Ito
Hisasi
H
Hasegawa
Tsutomu
T
Suzuki
Toshikazu
T
Adachi
Noritaka
N
Ayusawa
Dai
D
D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D007700:Kinetics; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D001973:Bromodeoxyuridine; D013936:Thymidine