Association of human cholesteryl ester transfer protein-TaqI polymorphisms with serum HDL cholesterol levels in a normolipemic Japanese rural population.
We examined allele frequencies for the common cholesteryl ester transfer protein (CETP) TaqI polymorphisms and the associations of CETP-TaqI polymorphisms with serum lipid and lipoprotein levels taking into account for selected lifestyle factors in a well-characterized random sample of 527 healthy subjects living a rural community in Japan (256 men and 271 women aged 40-69 years). B2 allele frequency was 0.39 in men and 0.41 in women, and its presence was significantly associated with increased levels of HDL cholesterol (HDL-C) in men (P=0.003 for linear trend). A similar tendency in women was observed, although P value for trend did not reach 0.05. There were not significant interactions between TaqIB genotype and smoking and alcohol drinking or daily physical activity in HDL-C. There were no statistically significant differences among TaqIA genotype in lipid and lipoprotein levels. Multiple linear regression analysis showed that B1B2 and B2B2 explained 1.7% and 2.2%, and 0.6% and 1.0% of variation in men and in women in HDL-C, respectively. We conclude that the CETP-TaqIB polymorphism has a quantitative influence, but appears to be stronger one in men, on HDL-C levels even after adjustment for important lifestyle factors (smoking, alcohol drinking, and daily physical activity).
Chen
Jianguo
J
Department of Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Japan.
Yokoyama
Tetsuji
T
Saito
Kyoko
K
Yoshiike
Nobuo
N
Date
Chigusa
C
Tanaka
Heizo
H
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology; D000483:Alleles; D001053:Apolipoproteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006023:Glycoproteins; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016014:Linear Models; D008055:Lipids; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012424:Rural Population; D012907:Smoking / Q000453:epidemiology; D019914:Taq Polymerase
D001053:Apolipoproteins; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D006023:Glycoproteins; D008055:Lipids; D019914:Taq Polymerase