[Serum level of secretory phospholipase A2 (sPLA2) as a predictor of restenosis after coronary angioplasty].
OBJECTIVE
To elucidate whether secretory phospholipase A2 (sPLA2) level in the blood and catalytic activity are significant predictors of restenosis after coronary angioplasty (CAP).


METHODS
Samples of venous blood were obtained from 24 patients before CAP and 1, 3, 6 days and 6 months after it. sPLA2 was measured with enzyme immunoassay, catalytic activity--using aqueous emulsion of 14C-labelled phosphatidylcholine. Control coronarography was performed in all the examinees 6 months after CAP.


RESULTS
Restenosis was detected in 13 patients. In the serum of their blood sPLA2 rose significantly after CAP and persisted for 6 days after it. If restenosis was not registered, this rise was insignificant and disappeared by day 6 after CAP. Catalytic activity of sPLA2 on day 6 after CAP was significantly higher in patients who later developed restenosis.


CONCLUSIONS
Elevated concentrations of sPLA2 in blood serum of patients after CAP may predict restenosis. Moreover, sPLA2 may not only mark inflammation but directly participate in development of restenosis.
Korotaeva
A A
AA
Provatorov
S I
SI
Samoĭlova
E V
EV
Kaminnyĭ
A I
AI
Sumarokov
A B
AB
Pirkova
A A
AA
Samko
A N
AN
Prokazova
N V
NV
D000328:Adult; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000201:enzymology* / Q000276:immunology / Q000628:therapy; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D011237:Predictive Value of Tests
D015415:Biomarkers; D010741:Phospholipases A; D054467:Phospholipases A2