title: Degraded limonoids from Melia azedarach and biogenetic implications.
abstract: The roots of Melia azedarach yielded three new degraded limonoids: teracrylmelazolide A, melazolide A and teracrylmelazolide B, possessing a previously undescribed skeleton. The known pyroangolensolide, fraxinellone and its three derivatives, 30-hydroxyfraxinellone, 9 alpha- and 9 beta-hydroxyfraxinellone, were also isolated. Their stereochemisty was elucidated on the basis of spectral data and chemical reactions.
authors.affiliation: Laboratorio di Chimica Bioorganica, Università degli Studi di Trento, Via Sommarive 14, I-38050 Povo-Trento, Italy. dambrosi@science.unitn.it
authors.forename: Michele
authors.initials: M
authors.lastname: D'Ambrosio
authors.forename: Antonio
authors.initials: A
authors.lastname: Guerriero
mesh_terms: D002845:Chromatography / Q000379:methods; D002942:Circular Dichroism; D007558:Italy; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification; D013058:Mass Spectrometry / Q000379:methods; D029582:Meliaceae / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D036701:Limonins; D010936:Plant Extracts