The correlation between relatives on the supposition of genomic imprinting.
Standard genetic analyses assume that reciprocal heterozygotes are, on average, phenotypically identical. If a locus is subject to genomic imprinting, however, this assumption does not hold. We incorporate imprinting into the standard quantitative-genetic model for two alleles at a single locus, deriving expressions for the additive and dominance components of genetic variance, as well as measures of resemblance among relatives. We show that, in contrast to the case with Mendelian expression, the additive and dominance deviations are correlated. In principle, this correlation allows imprinting to be detected solely on the basis of different measures of familial resemblances, but in practice, the standard error of the estimate is likely to be too large for a test to have much statistical power. The effects of genomic imprinting will need to be incorporated into quantitative-genetic models of many traits, for example, those concerned with mammalian birthweight.
Spencer
Hamish G
HG
Department of Zoology, University of Otago, Dunedin, New Zealand. h.spencer@otago.ac.nz
D014644:Genetic Variation; D018392:Genomic Imprinting; D005838:Genotype; D008957:Models, Genetic; D019655:Quantitative Trait, Heritable; D012044:Regression Analysis; D012727:Sex Characteristics