Long-term maintenance antiretroviral therapy with saquinavir hard gel, after voluntary abandonment of successful induction HAART.
HIV-infected patients who voluntarily resorted to an apparently suboptimal drug association including saquinavir hard gel after attaining viral suppression thanks to an antiretroviral regimen based on potent protease inhibitors, had a satisfactory 12-18-month clinical and laboratory outcome. The effects of a potent and sufficiently prolonged induction antiretroviral therapy may be maintained for 12 months or more, especially when the maintenance regimen includes novel nucleoside analogues, and specific genotypical mutations are absent.
Manfredi
R
R
Department of Clinical and Experimental Medicine, University of Bologna, Italy. manfredi@med.unibo.it
D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D019468:Disease Management; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D012367:RNA, Viral / Q000097:blood; D019258:Saquinavir / Q000627:therapeutic use*; D013997:Time Factors
D017320:HIV Protease Inhibitors; D012367:RNA, Viral; D019258:Saquinavir