Insensitivity to the bitter taste of chloramphenicol: an autosomal recessive trait.
Sensitivity to the bitter taste of chloramphenicol was studied in 860 students, 620 males and 240 females. About 8.6% of them were insensitive to this bitter taste. Familial lineage studies were carried out on a subset of these students, and the results suggested that the sensitivity or insensitivity was controlled by a pair of autosomal Mendelian genes, with the sensitive gene being dominant over the insensitive.
Sugino
Yoshinobu
Y
Laboratory of Molecular Biology, Kansai Medical University, Hirakata, Osaka, Japan. sugino@makino.kmu.ac.jp
Umemoto
Aiko
A
Mizutani
Satoshi
S
D000293:Adolescent; D000328:Adult; D002701:Chloramphenicol / Q000008:administration & dosage; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D010375:Pedigree; D010670:Phenylthiourea / Q000008:administration & dosage; D013649:Taste / Q000235:genetics*
D002701:Chloramphenicol; D010670:Phenylthiourea