title: Anti-androgenic and hair growth promoting activities of Lygodii spora (spore of Lygodium japonicum) I. Active constituents inhibiting testosterone 5alpha-reductase.
abstract: The aqueous ethanol extract of Lygodii Spora (spore of Lygodium japonicum (Thunb.) Sw.) showed in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. From the lipophilic constituents of Lygodii Spora, oleic, linoleic and palmitic acids were identified as the main active principles inhibiting testosterone 5alpha-reductase.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Osaka, Japan. matsuda@phar.kindai.ac.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Matsuda
authors.forename: Miho
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Naruo
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Asanuma
authors.forename: Michinori
authors.initials: M
authors.lastname: Kubo
mesh_terms: D058891:5-alpha Reductase Inhibitors; D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology; D029624:Ferns / Q000737:chemistry*; D006197:Hair / Q000187:drug effects / Q000254:growth & development*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D013170:Spores / Q000737:chemistry*; D013739:Testosterone / Q000494:pharmacology
chemical_list: D058891:5-alpha Reductase Inhibitors; D000726:Androgen Antagonists; D004791:Enzyme Inhibitors; D005227:Fatty Acids; D013739:Testosterone; D009277:Nandrolone; C005671:oxendolone