title: Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.
abstract: New C3-substituted beta-lactamase inhibitors were prepared and evaluated against representative class A and class C enzymes. It was possible to improve simultaneous inhibitory activity of both classes of serine hydrolase. Other inhibitors showed high selectivity for either the class C cephalosporinases or the class A penicillinases. This represents the first time that cephalosporin-derived inhibitors have demonstrated selectivity for the class A beta-lactamases.
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, TX 75275-0314, USA. jbuynak@mail.smu.edu
authors.forename: John D
authors.initials: JD
authors.lastname: Buynak
authors.forename: Lakshminarayana
authors.initials: L
authors.lastname: Vogeti
authors.forename: Venkata Ramana
authors.initials: VR
authors.lastname: Doppalapudi
authors.forename: George Martin
authors.initials: GM
authors.lastname: Solomon
authors.forename: Hansong
authors.initials: H
authors.lastname: Chen
mesh_terms: D002511:Cephalosporins / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D065093:beta-Lactamase Inhibitors
chemical_list: D002511:Cephalosporins; D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors