[Adverse reactions associated with the use of L-asparaginase during therapy of patients with nB non-Hodgkin's lymphoma. Report of the Polish Paediatric LeuKaemia/Lymphoma Study Group].
The aim of the study was to determine the side effects of asparaginase administration during treatment protocol for childhood non-Hodgkin's lymphoma (NHL). Drug adverse reactions occurred in 20/66 of patients (30,3%) treated in 9 centres in Poland between 1993 and 1998. The most common side effects were coagulation disturbances in 12/66 of the children (18,2%), which occurred due to reduced production of important coagulation factors. Six patients (9,1%) developed impairment of liver function (9,1%). Drug toxicity caused the modifications of treatment protocol in 12/66 (18,2%) of patients, mainly in the induction phase; 3 children died due to relapse of disease.
Wróbel
G
G
Klinika Hematologii i Chorob Rozrostowych Dzieci AM we Wrocławiu, ul. Bujwida 44, Poland.
Dobaczewski
G
G
Kazanowska
B
B
Bogusławska-Jaworska
J
J
Balwierz
W
W
Balcerska
A
A
Bubała
H
H
Dluzniewska
A
A
Kołecki
P
P
Kowalczyk
J
J
Kurylak
A
A
Maciejka-Kapuscinska
L
L
Matysiak
M
M
Rokicka-Milewska
R
R
Sońta-Jakimczyk
D
D
Sopyło
B
B
Stefaniak
M J
MJ
Stefańska
K
K
Stańczak
E
E
Wysocki
M
M
D000293:Adolescent; D000707:Anaphylaxis / Q000139:chemically induced; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects*; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D002675:Child, Preschool; D003920:Diabetes Mellitus / Q000139:chemically induced; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced; D007223:Infant; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced; D011044:Poland; D012189:Retrospective Studies; D012640:Seizures / Q000139:chemically induced; D013997:Time Factors
D000970:Antineoplastic Agents; D001215:Asparaginase