Solid-phase synthesis of lipidated peptides.
Characteristic partial structures of lipidated proteins embodying different lipid groups as well as additional fluorescent tags or a maleimide for coupling to proteins can be synthesized readily by means of a new solid-phase technique employing the oxidative cleavage of the hydrazide linker as well as on-resin farnesylation and palmitoylation after appropriate deprotection of cysteine thiol groups as the key steps.
Ludolph
Björn
B
Max-Planck-Institut für molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, D-44227 Dortmund, Germany.
Eisele
Frank
F
Waldmann
Herbert
H
D008055:Lipids / Q000138:chemical synthesis / Q000737:chemistry*; D008074:Lipoproteins / Q000138:chemical synthesis*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*
D008055:Lipids; D008074:Lipoproteins; D010455:Peptides