Cancer chemopreventive effects of a Brazilian folk medicine, Juca, on in vivo two-stage skin carcinogenesis.
Gallic acid (1) and methyl gallate (2) were isolated from Juca, a Brazilian folk medicine, fruits of Caesalpinia ferrea MART (Leguminosae), decreased significantly the average number of papillomas per mouse in the experiment of the promoting effects of 12-O-tetra- decanoylphorbol-13-acetate (TPA) on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene (DMBA).
Nakamura
Eliane S
ES
Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0194, Japan.
Kurosaki
Fumiya
F
Arisawa
Munehisa
M
Mukainaka
Teruo
T
Takayasu
Junko
J
Okuda
Masato
M
Tokuda
Harukuni
H
Nishino
Hoyoku
H
Pastore
Floriano
F
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology*; D001938:Brazil / Q000208:ethnology; D029911:Caesalpinia / Q000737:chemistry*; D005260:Female; D005638:Fruit / Q000737:chemistry; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D008519:Medicine, Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D016588:Anticarcinogenic Agents; D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene; C052082:methyl gallate; D005707:Gallic Acid; D013755:Tetradecanoylphorbol Acetate