title: Hepatoprotective effect of coumestans isolated from the leaves of Wedelia calendulacea Less. in paracetamol induced liver damage.
abstract: Effect of coumestans isolated form the leaves of W. calendulacea was evaluated in paracetamol induced liver damage. The increased serum enzyme levels (lactate dehydrogenase, alanine and aspartate transaminase and alkaline phophatase) by paracetamol induction were significantly lowered due to coumestans treatment. Results of this study revealed that coumestans of W. calendulacea afforded a significant protective action in the alleviation of paracetamol induced hepatocellular injury.
authors.affiliation: Entomology Research Institute, Loyola College, Chennai, India.
authors.forename: S
authors.initials: S
authors.lastname: Emmanuel
authors.forename: T
authors.initials: T
authors.lastname: Amalraj
authors.forename: S
authors.initials: S
authors.lastname: Ignacimuthu
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D000135:Acid Phosphatase / Q000378:metabolism; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D019659:Asteraceae / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D000082:Acetaminophen; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000135:Acid Phosphatase