[Immunogenicity of retina in mice].
OBJECTIVE
To evaluate the immunogenicity of retina.


METHODS
DBA/2 mice (MHCH-2d) were used as donors, C57BL/6 mice (MHC H-2d) or BALB/C mice (MHC H-2d) as recipients. Half retina of DBA/2 mouse was transplanted subcutaneously to a C57BL/6 or BALB/C mouse. The delayed-type hypersensitivity (DTH) and specific killing rate of cytotoxic T lymphocyte(CTL) were detected two weeks later.


RESULTS
The results of DTH and specific killing rate of CTL in the retina of DBA/2 mice were significantly lower than the positive group(P < 0.01), but significantly higher than the negative group(P < 0.01).


CONCLUSIONS
MHC Class I and Class II antigen and minor histocompatibility complex antigen(Minor HC) are expressed in the retina of the DBA/2 mouse, which stimulates immune system of recipient to produce weak cellular immune response. It is suggested that the retina has weak immunogenicity.
Gao
L
L
Department of Ophthalmology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Jiang
D
D
D000818:Animals; D003602:Cytotoxicity, Immunologic; D005260:Female; D006968:Hypersensitivity, Delayed; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012160:Retina / Q000276:immunology* / Q000637:transplantation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*