[Transcriptional activation study of transforming gene Tx-related human nasopharyngeal carcinoma].
Tx gene is the DNA sequence with transforming activity which was cloned from the epithelial cell line (CNE2) of human nasopharyngeal carcinoma(NPC). The goal of this study is to find transcriptional activated site on the Tx 2.8 kb fragment using DNase-I hypersensitivity assay, by which understanding the role of the Tx in carcinogenesis of NPC. The results showed no DNase-I hypersensitivity site on the fragment. It suggests that Tx 2.8 kb fragment homogenous to Ig kappa C might be regulated by the specific mechanism of immunoglobulin gene, rather than that of oncogenes.
Peng
B
B
Institute of Cancer Research, Hunan Medical University, Changsha 410078.
Cao
L
L
Li
G
G
Yao
K
K
D003851:Deoxyribonucleases / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D009857:Oncogenes; D014170:Transformation, Genetic
D007136:Immunoglobulins; D003851:Deoxyribonucleases