Parasitenone, a new epoxycyclohexenone related to gabosine from the marine-derived fungus Aspergillus parasiticus.
Bioassay-guided fractionation of an organic extract of the broth from the marine-derived fungus culture of Aspergillus parasiticus led to the isolation and subsequent structural elucidation of a new gabosine derivative, parasitenone (1), and two known benzyl alcohols, 3-chloro-4,5-dihydroxybenzyl alcohol (2) and gentisyl alcohol (3). The benzyl alcohols (2, 3) were identified as the principal free radical scavenging components. Parasitenone (1) also showed moderate activity in the free radical scavenging assay.
Son
Byeng Wha
BW
Department of Chemistry, Pukyong National University, Busan 608-737, Korea. sonbw@pknu.ac.kr
Choi
Jin Seok
JS
Kim
Jung Chul
JC
Nam
Ki Wan
KW
Kim
Dong-Soo
DS
Chung
Hae Young
HY
Kang
Jung Sook
JS
Choi
Hong Dae
HD
D000107:Acetylation; D001230:Aspergillus / Q000737:chemistry*; D001592:Benzyl Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003512:Cyclohexanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007723:Korea; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
D001592:Benzyl Alcohols; D003512:Cyclohexanones; D004852:Epoxy Compounds; D016166:Free Radical Scavengers; C461799:parasitenone