title: Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia.
abstract: It was recently demonstrated that renal failure and exogenous urea prevent myelinolysis induced by rapid correction of experimental hyponatremia. To determine why elevated blood urea levels favorably affect brain tolerance to osmotic stress, the changes in brain solute composition that occur when chronic hyponatremia is rapidly corrected were studied in rats with or without mercuric chloride-induced renal failure. After 48 h of hyponatremia, the brains of azotemic and nonazotemic animals became depleted of sodium, potassium, and organic osmolytes. Twenty-four hours after rapid correction of hyponatremia, the brains of animals without azotemia remained depleted of organic osmolytes, with little increase in myo-inositol or taurine contents above those observed in animals with uncorrected hyponatremia; brain electrolytes were rapidly reaccumulated, increasing the brain sodium content to a level 17% higher than values for normonatremic control animals. In contrast, within 2 h after correction of hyponatremia, brain myo-inositol contents in azotemic rats returned to control levels and brain taurine levels were significantly higher than those in azotemic animals with uncorrected hyponatremia (16.5 versus 9 micromol/g dry weight). There was no "overshooting" of brain sodium and water contents after rapid correction in the azotemic animals. Rapid reaccumulation of brain organic osmolytes after correction of hyponatremia could explain why azotemia protects against myelinolysis.
authors.affiliation: Department of Internal Medicine, Jolimont/Tubize-Nivelles Hospital, Tubize-Nivelles, Belgium. cpiesen@ulb.ac.be
authors.forename: Alain
authors.initials: A
authors.lastname: Soupart
authors.forename: Stephen
authors.initials: S
authors.lastname: Silver
authors.forename: Barbara
authors.initials: B
authors.lastname: Schroöeder
authors.forename: Richard
authors.initials: R
authors.lastname: Sterns
authors.forename: Guy
authors.initials: G
authors.lastname: Decaux
mesh_terms: D000818:Animals; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002908:Chronic Disease; D007010:Hyponatremia / Q000378:metabolism*; D007294:Inositol / Q000378:metabolism*; D008297:Male; D008627:Mercuric Chloride / Q000633:toxicity; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism; D013654:Taurine / Q000378:metabolism; D014508:Urea / Q000097:blood; D014511:Uremia / Q000378:metabolism*; D014882:Water-Electrolyte Balance
chemical_list: D013654:Taurine; D007294:Inositol; D008627:Mercuric Chloride; D014508:Urea; D012964:Sodium; D011188:Potassium