Long-term follow up of subthalamic nucleus stimulation in Parkinson's disease.
Twenty-two patients with PD received bilateral implants for high frequency stimulation of the subthalamic nucleus. The patients were treated for more than 1 year (up to 36 months). At the last visit, the Unified Parkinson Disease Rating Scale (UPDRS) motor score without medication improved by 50.2% (p < 0.001) and the UPDRS activities of daily living score improved by 68.4% (p < 0.001). The most common long-lasting adverse events were hypophonia and dysarthria; transient events were increased sexuality and mania. The surgical procedure induced transient intraoperative psychosis in seven patients.
Romito
L M A
LM
Istituto di Neurologia, Università Cattolica del Sacro Cuore, Rome.
Scerrati
M
M
Contarino
M F
MF
Bentivoglio
A R
AR
Tonali
P
P
Albanese
A
A
D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D000368:Aged; D004599:Electric Stimulation Therapy / Q000009:adverse effects / Q000379:methods / Q000523:psychology / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008134:Long-Term Care / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000523:psychology / Q000628:therapy*; D020531:Subthalamic Nucleus