Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats.
Administration of aqueous extracts of V. rosea flower and leaf have been found to regulate the blood sugar level in alloxan diabetic male albino rats. V. rosea therapy not only produced blood glucose homeostasis but also reversed changes in carbohydrate, protein, lipid metabolisms and metabolic and pathologic changes that took place in pancreatic islet cells, liver and kidney following a single dose (150 mg/kg body weight) of alloxan monohydrate. B-cell secretory activity resumed near-normalcy as evidenced by near-normal serum insulin concentration and electron-microscopic study proving that V. rosea manifests its beneficial activity through B-cell rejuvenation, regeneration and stimulation.
Ghosh
S
S
Department of Life Sciences, St Xavier's College, Mahapalika Marg, Mumbai, India.
Suryawanshi
S A
SA
D000496:Alloxan; D000818:Animals; D029062:Apocynaceae / Q000737:chemistry*; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000473:pathology; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D010179:Pancreas / Q000473:pathology; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan