The stability of oxymetazoline hydrochloride in aqueous solution.
The kinetics of the hydrolysis reaction of oxymetazoline hydrochloride in aqueous solution at three temperatures (343 K, 353 K, 363 K), over the pH-range 0.5-12.5 and ionic strength 0.5 has been investigated. The changes of concentration of oxymetazoline hydrochloride were followed by the HPLC method with UV detection. In the pH range from 0.45 to 12.50, the hydrolysis of oxymetazoline consists of hydrolysis of oxymetazoline molecules catalyzed by hydrogen ions, spontaneous hydrolysis of the dissociated and undissociated oxymetazoline molecules. A minimal rate of the hydrolysis oxymetazoline was observed to occur in the pH range from 2.0 to 5.0. Thermodynamic parameters of the reaction: energy, entropy and enthalpy of activation and the frequency factor for the specific rate constants were determined.
Stanisz
Beata
B
Department of Pharmaceutical Chemistry, K. Marcinkowski Medical University, Poznań, Poland.
D004355:Drug Stability; D014663:Nasal Decongestants / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D010109:Oxymetazoline / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D019999:Pharmaceutical Solutions / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D014867:Water / Q000032:analysis / Q000737:chemistry / Q000378:metabolism
D014663:Nasal Decongestants; D019999:Pharmaceutical Solutions; D014867:Water; D010109:Oxymetazoline