Prophylactic intracameral cefuroxime. Efficacy in preventing endophthalmitis after cataract surgery.
OBJECTIVE
To evaluate the efficacy of prophylactic intracameral cefuroxime in preventing endophthalmitis in cataract surgery.


METHODS
Department of Ophthalmology, St. Eriks Hospital, Stockholm, Sweden.


METHODS
In a noncontrolled retrospective observational study, all cases of recorded postoperative endophthalmitis were related to the total number of uncombined cataract procedures from January 1996 to December 2000.


RESULTS
Twenty cases of postoperative endophthalmitis occurred in 32180 procedures, yielding an overall rate of 0.06%. Cefuroxime-resistant organisms accounted for 12 of 13 culture-positive cases, and enterococci were the most common etiology.


CONCLUSIONS
Intracameral cefuroxime 1 mg appeared to effectively inhibit sensitive bacterial strains and was associated with a low frequency of postoperative endophthalmitis. The causative organisms of future incidents of postoperative endophthalmitis will determine whether the present protocol must be reappraised.
Montan
Per G
PG
Department of Ophthalmology, St. Eriks Hospital, Stockholm, Sweden.
Wejde
Gisela
G
Koranyi
Gabor
G
Rylander
Margareta
M
D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000187:drug effects*; D019072:Antibiotic Prophylaxis; D002387:Cataract Extraction / Q000009:adverse effects*; D002444:Cefuroxime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D009877:Endophthalmitis / Q000382:microbiology / Q000517:prevention & control*; D015818:Eye Infections, Bacterial / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D002511:Cephalosporins; D002444:Cefuroxime