title: Stress-induced premature senescence: from biomarkers to likeliness of in vivo occurrence.
abstract: The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of 'molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.
authors.affiliation: University of Namur, Unit of Cellular Biochemistry, Belgium. olivier.toussaint@fundp.ac.be
authors.forename: Olivier
authors.initials: O
authors.lastname: Toussaint
authors.forename: José
authors.initials: J
authors.lastname: Remacle
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dierick
authors.forename: Thierry
authors.initials: T
authors.lastname: Pascal
authors.forename: Christophe
authors.initials: C
authors.lastname: Frippiat
authors.forename: Véronique
authors.initials: V
authors.lastname: Royer
authors.forename: Joao Pedro
authors.initials: JP
authors.lastname: Magalhacs
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Zdanov
authors.forename: Florence
authors.initials: F
authors.lastname: Chainiaux
mesh_terms: D019588:Aging, Premature / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers; D016207:Cytokines / Q000378:metabolism; D005720:Gamma Rays; D006801:Humans; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress; D014466:Ultraviolet Rays
chemical_list: D015415:Biomarkers; D016207:Cytokines; D016877:Oxidants