Anaphylaxis after first exposure to ceftriaxone.
Life-threatening anaphylaxis developed in a 5-y-old boy with septic shock within minutes of receiving his first intravenous injection of ceftriaxone. Hypersensivity could not be demonstrated by skin testing and ceftriaxone-specific IgE. However, an in vivo, controlled, intravenous challenge was clearly positive.


CONCLUSIONS
Clinicians should be aware of the possibility of anaphylaxis occurring with the first dose of ceftriaxone, especially since such a reaction could go unnoticed in patients with life-threatening infections and unstable vital signs.
Ernst
M R
MR
Department of Paediatrics, St Elisabeth Hospital, Tilburg, The Netherlands.
van Dijken
P J
PJ
Kabel
P J
PJ
Draaisma
J M Th
JM
D000707:Anaphylaxis / Q000139:chemically induced*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000009:adverse effects*; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010328:Patch Tests; D018570:Risk Assessment; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000188:drug therapy*
D002443:Ceftriaxone