title: Metal transporters and disease.
abstract: Iron and copper are essential nutrients that must be meticulously regulated to exploit their usefulness in biological reactions while protecting against their tendency to promote formation of toxic free-radicals. This review summarizes recently described steps in the transport of these metals, and explores how defects in these steps lead to human diseases including hemochromatosis, Menkes disease and Wilson disease.
authors.affiliation: HHMI/Hematology, Enders 720, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA. nandrews@genetics.med.harvard.edu
authors.forename: Nancy C
authors.initials: NC
authors.lastname: Andrews
mesh_terms: D001692:Biological Transport; D027682:Cation Transport Proteins / Q000378:metabolism*; D003300:Copper / Q000493:pharmacokinetics*; D006801:Humans; D007501:Iron / Q000493:pharmacokinetics*; D008664:Metal Metabolism, Inborn Errors / Q000209:etiology
chemical_list: D027682:Cation Transport Proteins; D003300:Copper; D007501:Iron