In-vitro interaction of cephalosporin and the immune system.
In this study we have evaluated the effects of an antibiotic, such as cefonicid, on some immune reactivities in vitro. The following immune parameters have been analyzed: i) interferon-gamma and interleukin-2 production and ii) lymphocyte proliferation following mitogen stimulation in the presence of cefonicid concentrations ranging from 50 to 500 microg/ml. No. decrease in lymphokine production in the presence of cefonicid concentrations up to 250 microg/ml was observed between untreated or antibiotic-treated lymphocyte cultures. When lymphocyte proliferation upon Con A stimulation, as evaluated by 3H-dHtd incorporation, was measured in the presence of cefonicid, no differences were observed with untreated controls. These results demonstrate that the in vitro interaction of cefonicid with the immune system does not lead to a decrease of the immune response.
Gariglio
M
M
Institute of Microbiology, Medical School, University of Torino, Italy.
Martinotti
M G
MG
Cavallo
G
G
Landolfo
S
S
D015790:Cefonicid / Q000494:pharmacology*; D018929:Cell Culture Techniques; D002511:Cephalosporins / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000502:physiology
D002511:Cephalosporins; D016207:Cytokines; D015790:Cefonicid