GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats.
The goal of this study was to determine the distribution of unbound amprenavir in the central nervous system (CNS) of rats. The concentration of unbound amprenavir in the extracellular fluid of the brain and the blood was examined in the presence and absence of the MDR modulator GF120918 by microdialysis. The brain-to-blood ratio of amprenavir in the absence and presence of GF120918 was found to be significantly different (P < 0.003; 0.076 and 0.617, respectively). The use of the MDR modulator GF120918 could potentially increase the penetration of human immunodeficiency virus protease inhibitors into the CNS.
Edwards
Jeffrey E
JE
Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA.
Brouwer
Kenneth R
KR
McNamara
Patrick J
PJ
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D000166:Acridines / Q000494:pharmacology*; D019380:Anti-HIV Agents / Q000493:pharmacokinetics*; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D002219:Carbamates; D005663:Furans; D017320:HIV Protease Inhibitors / Q000493:pharmacokinetics*; D007546:Isoquinolines / Q000494:pharmacology*; D017551:Microdialysis; D013449:Sulfonamides / Q000493:pharmacokinetics*; D044005:Tetrahydroisoquinolines
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000166:Acridines; D019380:Anti-HIV Agents; D002219:Carbamates; D005663:Furans; D017320:HIV Protease Inhibitors; D007546:Isoquinolines; D013449:Sulfonamides; D044005:Tetrahydroisoquinolines; C095108:amprenavir; C083501:Elacridar