title: Lithium dilution cardiac output measurement in oleic acid-induced pulmonary edema.
abstract: OBJECTIVE
  To determine whether lung injury influences the accuracy of lithium dilution cardiac output (CO) measurement.
  
  
  METHODS
  Animal experimental study.
  
  
  METHODS
  Animal experimental laboratory.
  
  
  METHODS
  Swine (n = 23) weighing 26.4 +/- 2.47 kg (mean +/- SD).
  
  
  METHODS
  The animals were anesthetized and tracheotomized, then a pulmonary artery catheter was inserted into the right jugular vein, and a catheter (18G) was placed in the femoral artery. After median sternotomy and pericardiotomy, a left ventricular catheter (18G) was directly inserted. CO was measured by giving a bolus injection of lithium chloride into either the right atrium or the left ventricle in each animal. After control measurements, permeability pulmonary edema was initiated by infusing oleic acid into the central vein (injury). About 2 hours after oleic acid infusion, CO measurements were repeated in the same manner as the control measurement had been taken.
  
  
  RESULTS
  Under each condition, right atrium lithium injection was similar to left ventricle lithium injection. The mean of these differences at injury (-0.06 +/- 0.55 L/min) was the same as that at control (-0.05 +/- 0.36 L/min).
  
  
  CONCLUSIONS
  Although the variability of lithium dilution CO measurement after oleic acid-induced pulmonary edema was greater than that of the control, this technique was acceptable even in cases of lung injury.
authors.affiliation: Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Hamamatsu, Japan. tadkur@hama-med.ac.jp
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Kurita
authors.forename: Koji
authors.initials: K
authors.lastname: Morita
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawasaki
authors.forename: Kiyoyasu
authors.initials: K
authors.lastname: Fujii
authors.forename: Tomiei
authors.initials: T
authors.lastname: Kazama
authors.forename: Shigehito
authors.initials: S
authors.lastname: Sato
mesh_terms: D000818:Animals; D006328:Cardiac Catheterization; D002302:Cardiac Output; D002407:Catheterization, Swan-Ganz; D006325:Heart Atria; D006352:Heart Ventricles; D007201:Indicator Dilution Techniques; D018021:Lithium Chloride; D019301:Oleic Acid; D011654:Pulmonary Edema / Q000139:chemically induced / Q000503:physiopathology*; D013552:Swine
chemical_list: D019301:Oleic Acid; D018021:Lithium Chloride