Three new hydroxylated serratidine alkaloids from Huperzia serrata.
A known compound, serratidine (1), along with three hydroxylated serratidine alkaloids, 6alpha-hydroxyserrati dine (2), 4alpha-hydroxyserratidine (3) and 4alpha,6alpha-dihydroxyserratidine (4) were isolated from the CHCl3 fraction of basic materials of whole plant of the Chinese medicinal herb Huperzia serrata. The relative configurations of the above compounds were determined based on 2D NMR studies.
Tan
Chang-Heng
CH
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.
Ma
Xiao-Qiang
XQ
Jiang
Shan-Hao
SH
Zhu
Da-Yuan
DY
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D002855:Chromatography, Thin Layer; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
C458959:4,6-dihydroxyserratidine; C458939:4-hydroxyserratidine; C458919:6-hydroxyserratidine; D000470:Alkaloids; D004365:Drugs, Chinese Herbal; C458904:serratidine