title: Ammonia detoxification by continuous venovenous haemofiltration in an infant with urea cycle defect.
abstract: We report the case of a newborn baby with carbamoyl phosphate synthetase deficiency. He presented at 2 weeks of life, deteriorating to a state of hyperammonaemic coma and respiratory failure. Rapid detoxification was successfully achieved by continuous venovenous haemofiltration while a definitive diagnosis and treatment were determined. The ammonia clearance achieved by continuous venovenous haemofiltration was greater than 20 mL/min/m(2), which is superior to that achieved by peritoneal dialysis and arteriovenous haemofiltration in this age-group.
authors.affiliation: Department of Paediatrics, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong.
authors.forename: W K Y
authors.initials: WK
authors.lastname: Chan
authors.forename: W M
authors.initials: WM
authors.lastname: But
authors.forename: C W
authors.initials: CW
authors.lastname: Law
mesh_terms: D000641:Ammonia / Q000097:blood*; D020165:Carbamoyl-Phosphate Synthase I Deficiency Disease / Q000150:complications; D006440:Hemofiltration; D006801:Humans; D022124:Hyperammonemia / Q000209:etiology / Q000628:therapy*; D007231:Infant, Newborn; D008297:Male; D012131:Respiratory Insufficiency / Q000209:etiology
chemical_list: D000641:Ammonia