[Research progresses of the synthesis and application of oligopeptide containing Arg-Gly-Asp sequence].
Arg-Gly-Asp (RGD) is one of the oligopeptides with biological activity found in recent years. It is the minimum ammonia serial on the ligand, which can be recognized by most of the integrins. It has important influence on the recognition of endothelial cell, anti-thrombus and anti-tumour function, and the therapy of burn and skin helcosis. In this review, the synthesis and application of oligopeptide [correction of oligepoptide] containing RGD sequence were discussed.
Zuo
Bin-hai
BH
Department of Applied Chemistry, Sichuan University, Cheng-du, China.
Fu
Qing-quan
QQ
Li
Tian-quan
TQ
Wan
Chang-xiu
CX
D000595:Amino Acid Sequence; D000970:Antineoplastic Agents; D002626:Chemistry, Pharmaceutical; D005343:Fibrinolytic Agents; D016023:Integrins; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D011137:Polystyrenes / Q000737:chemistry; D011971:Receptors, Immunologic; D012117:Resins, Synthetic
D000970:Antineoplastic Agents; D005343:Fibrinolytic Agents; D016023:Integrins; C095039:Merrifield resin; D009842:Oligopeptides; D011137:Polystyrenes; D011971:Receptors, Immunologic; D012117:Resins, Synthetic; C047981:arginyl-glycyl-aspartic acid