title: Novel plasmid-encoded class C beta-lactamase (MOX-2) in Klebsiella pneumoniae from Greece.
abstract: Klebsiella pneumoniae KOL, a clinical strain resistant to various beta-lactams, was isolated from the stools of a patient from Greece. This strain harbored a new pI 9.1 plasmid-mediated AmpC beta-lactamase with unusually high levels of hydrolytic activity for cefoxitin and cefotetan that we named MOX-2. Sequencing of bla(MOX-2) revealed 93.2, 92.9, 92.7, and 73.1% identities with the deduced amino acid sequences of CMY-8, MOX-1, CMY-1, and the AmpC beta-lactamase of Aeromonas sobria, respectively.
authors.affiliation: Service de Bacteriologie-Virologie, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, 75475 Paris Cedex 10, France. laurent.raskine@lrb.ap-hop-paris.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Raskine
authors.forename: Isabelle
authors.initials: I
authors.lastname: Borrel
authors.forename: Guilène
authors.initials: G
authors.lastname: Barnaud
authors.forename: Sophie
authors.initials: S
authors.lastname: Boyer
authors.forename: Béatrice
authors.initials: B
authors.lastname: Hanau-Berçot
authors.forename: Jérome
authors.initials: J
authors.lastname: Gravisse
authors.forename: Roger
authors.initials: R
authors.lastname: Labia
authors.forename: Guillaume
authors.initials: G
authors.lastname: Arlet
authors.forename: Marie-José
authors.initials: MJ
authors.lastname: Sanson-Le-Pors
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D007711:Klebsiella pneumoniae / Q000235:genetics*; D008969:Molecular Sequence Data; D010957:Plasmids; D001618:beta-Lactamases / Q000737:chemistry / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; C048795:AmpC beta-lactamases; D001618:beta-Lactamases