title: Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity.
abstract: Peloruside A is a novel secondary metabolite isolated from a New Zealand marine sponge, Mycale hentscheli, that has potent paclitaxel-like microtubule-stabilizing activity and is cytotoxic at nanomolar concentrations. Its 16-membered macrolide ring is similar to that of epothilone, a drug currently under clinical investigation as an anticancer agent. Like paclitaxel, peloruside A arrests cells in the G(2)-M phase of the cell cycle and induces apoptosis. The relatively simple structure of peloruside makes it suitable for the design and synthesis of analogues with improved tumor targeting and reduced tumor cross-resistance.
authors.affiliation: School of Biological Sciences, Victoria University of Wellington, New Zealand.
authors.forename: Kylie A
authors.initials: KA
authors.lastname: Hood
authors.forename: Lyndon M
authors.initials: LM
authors.lastname: West
authors.forename: Berber
authors.initials: B
authors.lastname: Rouwé
authors.forename: Peter T
authors.initials: PT
authors.lastname: Northcote
authors.forename: Michael V
authors.initials: MV
authors.lastname: Berridge
authors.forename: St John
authors.initials: SJ
authors.lastname: Wakefield
authors.forename: John H
authors.initials: JH
authors.lastname: Miller
mesh_terms: D000199:Actins / Q000378:metabolism; D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D034261:Epothilones; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D018942:Macrolides / Q000737:chemistry / Q000494:pharmacology; D008870:Microtubules / Q000187:drug effects; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D043823:Taxoids; D014404:Tubulin / Q000378:metabolism
chemical_list: D000199:Actins; D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D034261:Epothilones; D007783:Lactones; D018942:Macrolides; D043823:Taxoids; D014404:Tubulin; C117305:laulimalide; C414085:peloruside A; D017239:Paclitaxel; C093788:epothilone B