Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells.
The epithelial component of the thymic microenvironment is indispensable for the generation of T lymphocytes. Although the heterogeneity of this epithelium is well documented, little is known about precursor-progeny relationships between distinct thymic epithelial lineages. Here we characterized a thymic epithelial cell subpopulation identified by the cell surface glycoprotein MTS24. These cells contained epithelial progenitor cells that were competent and sufficient to fully reconstitute the complex thymic epithelial microenvironment that supported normal T cell development.
Gill
Jason
J
Department of Pathology and Immunology, Monash University Medical School, Commercial Road, Prahran, Melbourne 3181, Australia. jason.gill@med.monash.edu.au
Malin
Mark
M
Holländer
Georg A
GA
Boyd
Richard
R
D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation; D019070:Cell Lineage; D004268:DNA-Binding Proteins / Q000235:genetics; D005314:Embryonic and Fetal Development; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology; D005260:Female; D051858:Forkhead Transcription Factors; D015870:Gene Expression; D006411:Hematopoiesis, Extramedullary / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D018398:Homeodomain Proteins / Q000235:genetics; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D051761:Paired Box Transcription Factors; D019089:Stem Cell Factor / Q000235:genetics; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics
D015415:Biomarkers; D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; D018398:Homeodomain Proteins; C080331:Hoxa3 protein, mouse; D008562:Membrane Glycoproteins; D051761:Paired Box Transcription Factors; D019089:Stem Cell Factor; D014157:Transcription Factors; C090140:Whn protein; C070835:PAX1 transcription factor