Evaluation and development of spinosyns to control ectoparasites on cattle and sheep.
The spinosyns are a novel family of fermentation-derived natural products that exhibit potent insecticidal activities. Spinosad, a naturally-occurring mixture of spinosyn A and spinosyn D, has successfully established its utility for crop protective applications in the agrochemical field. Potential applications of this unique chemical family of macrolides also have been investigated in the field of animal health. Applications for the control of blowfly strike and lice on sheep have now been commercially developed and registered in Australia and potential applications for the control of ectoparasites on cattle are being studied.
Kirst
Herbert A
HA
Elanco Animal Health Research and Development, 2001 West Main Street, Greenfield, Indiana 46140, USA. kirst_herbert_a@lilly.com
Creemer
Lawrence C
LC
Naylor
Sharon A
SA
Pugh
Paul T
PT
Snyder
Daniel E
DE
Winkle
Joseph R
JR
Lowe
L Barry
LB
Rothwell
James T
JT
Sparks
Thomas C
TC
Worden
Thomas V
TV
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D002417:Cattle; D004341:Drug Evaluation; D004478:Ectoparasitic Infestations / Q000188:drug therapy* / Q000517:prevention & control / Q000662:veterinary; D007313:Insecta / Q000187:drug effects; D018942:Macrolides; D012756:Sheep; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D018942:Macrolides; C114883:spinosyn A; C114884:spinosyn D