The first synthetic receptor for the RGD sequence.
[structure: see text] The combination of an optimized arginine receptor unit with a semirigid linker carrying a strategically placed primary ammonium group leads to the first synthetic RGD receptor. It binds to the free RGD peptide as well as to cyclo(RGDfV) in water with association constants around 1000 M(-1). RGD mimetics such as benzamidine 6 are not recognized, rendering the new host a prototype of a new class of receptors selective for the true RGD sequence in peptides.
Rensing
Stephan
S
Fachbereich Chemie, Universität Marburg, Hans-Meerwein-Strasse, 35032 Marburg, Germany.
Schrader
Thomas
T
D006860:Hydrogen Bonding; D016023:Integrins / Q000037:antagonists & inhibitors / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D018716:Molecular Mimicry; D015394:Molecular Structure; D009842:Oligopeptides / Q000378:metabolism*; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors / Q000737:chemistry*; D018000:Receptors, Peptide / Q000037:antagonists & inhibitors / Q000737:chemistry*; D013379:Substrate Specificity; D017186:Titrimetry
D016023:Integrins; D008024:Ligands; D009842:Oligopeptides; D010446:Peptide Fragments; D011971:Receptors, Immunologic; D018000:Receptors, Peptide; C051382:arginyl-glycyl-aspartic acid directed cell adhesion receptor; C047981:arginyl-glycyl-aspartic acid