The effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities.
In this study, the effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities was investigated. Forty male BALB/c mice were used as material. Ten mice served as a control group, and 30 mice were injected with tilmicosin (25 mg/kg body weight, subcutaneously, with a single injection). After drug administration, they were monitored for 3 days. Tilmicosin caused decreases in cardiac superoxide dismutase and glutathione peroxidase activities.
Yazar
E
E
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey.
Altunok
V
V
Elmas
M
M
Traş
B
B
Baş
A L
AL
Ozdemir
V
V
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000378:metabolism*; D006321:Heart / Q000187:drug effects*; D018942:Macrolides; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism*; D015645:Tylosin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D018942:Macrolides; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C052319:tilmicosin; D015645:Tylosin