Alpha-fetoprotein- and des-gamma-carboxy prothrombin-producing advanced gastric cancer.
A case of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) producing gastric cancer with multiple liver metastasis is reported. The simultaneous presence of Borrmann I gastric cancer and IIa aggregating type gastric cancer was noted. Borrmann I gastric cancer was a poorly differentiated adenocarcinoma, while IIa aggregating type gastric cancer was a moderately differentiated adenocarcinoma. Plasma levels of AFP and DCP were 247,000 ng/ml and 320,000 mAU/ml, respectively. Immunohistochemical staining confirmed the production of these two proteins in Borrmann I gastric cancer.
Ando
Eiji
E
Department of Medicine II, Kurume University School of Medicine, 67, Asahi-Machi, Kurume-shi, Fukuoka-ken, 830-0011, Japan. nyando@med-kurume-u.ac.jp
Oriishi
Tetsuharu
T
Toyonaga
Atsushi
A
Tobaru
Takeshi
T
Tanaka
Masatoshi
M
Shimamura
Ryuji
R
Terai
Yuji
Y
Nakajima
Yutaka
Y
Sata
Michio
M
D000230:Adenocarcinoma / Q000378:metabolism*; D015415:Biomarkers; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000096:biosynthesis*; D011516:Prothrombin / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000378:metabolism*; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D015415:Biomarkers; D014408:Biomarkers, Tumor; D011498:Protein Precursors; D000509:alpha-Fetoproteins; C008208:acarboxyprothrombin; D011516:Prothrombin