Parvalbumin-containing interneurons in rat hippocampus have an AMPA receptor profile suggestive of vulnerability to excitotoxicity.
alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors mediate excitatory neurotransmission in the central nervous system, and contain combinations of four subunits (GluR1-4). We developed a GluR3-specific monoclonal antibody and quantified the cellular distribution of GluR3 in rat hippocampus. GluR3 immunoreactivity was detected in all pyramidal neurons and most interneurons. In addition, we found a subset of parvalbumin (PV)-containing interneurons in the hippocampus and neocortex that was notable for its intense GluR3 immunoreactivity and lack of GluR2 immunoreactivity. Such an expression pattern of AMPA receptor subunits is likely to make these interneurons selectively vulnerable to excitotoxicity.
Moga
Diana
D
Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, Box 1639, One Gustave L. Levy Place, New York, NY 10029-6574, USA.
Hof
Patrick R
PR
Vissavajjhala
Prabhakar
P
Moran
Thomas M
TM
Morrison
John H
JH
D000818:Animals; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D006624:Hippocampus / Q000737:chemistry* / Q000187:drug effects; D007395:Interneurons / Q000737:chemistry* / Q000187:drug effects; D010320:Parvalbumins / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000032:analysis*
D018690:Excitatory Amino Acid Agonists; D010320:Parvalbumins; D018091:Receptors, AMPA; C104723:glutamate receptor ionotropic, AMPA 3