title: Clinical efficacy of chloroquine or sulfadoxine-pyrimethamine in children under five from south-western Uganda with uncomplicated falciparum malaria.
abstract: We conducted a 14-day study (during March-May 1998) to assess the efficacy of chloroquine and sulfadoxine-pyrimethamine (SP) for treating uncomplicated Plasmodium falciparum malaria in Uganda. Overall treatment failure rates were 43 (81.1%) of 53 chloroquine recipients and 16 (25.0%) of 64 SP patients. Strategies to improve the life-span of standard and affordable anti-malarial drugs are needed.
authors.affiliation: Epicentre, P.O. Box 2362, Kampala, Uganda.
authors.forename: D
authors.initials: D
authors.lastname: Legros
authors.forename: K
authors.initials: K
authors.lastname: Johnson
authors.forename: P
authors.initials: P
authors.lastname: Houpikian
authors.forename: M
authors.initials: M
authors.lastname: Makanga
authors.forename: J K
authors.initials: JK
authors.lastname: Kabakyenga
authors.forename: A O
authors.initials: AO
authors.lastname: Talisuna
authors.forename: W R J
authors.initials: WR
authors.lastname: Taylor
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use*; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D011739:Pyrimethamine / Q000627:therapeutic use*; D013413:Sulfadoxine / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D002738:Chloroquine; D011739:Pyrimethamine