Toxicological study of a glucose-added acetic acid maintenance infusion solution (VEEN 3G Inj.) local irritation test.
The local irritating effect of Veen 3G Inj. (glucose-added acetic acid maintenance infusion solution) was examined in male rabbits. We studied the local irritating effect of the infusion solution compared with that of Ringer's solution, 5% sulfobromophthalein sodium injection, distilled water for injection or glucose-added Ringer's solution. In the vascular irritation test, macroscopical and histopathological changes induced by the infusion solution were not observed in the vessels. Moreover, in the hemolytic test, hemolysis of rabbit erythrocyte was not observed in the mixture with the infusion solution. In the present study, no change suggesting irritation by the infusion solution was observed in the in vivo vascular irritation test using the auricular vein of rabbits or in the in vitro hemolytic test using rabbit erythrocyte. In conclusion, in clinical use the infusion solution produces extremely slight adverse effects, such as vessel pain and phlebitis on the injection site.
Onodera
K
K
Department of Dental Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. onoderak@md.okayama-u.ac.jp
Kawaguch
M
M
Shibata
M
M
Kagawa
M
M
Kojima
J
J
Shimizu
K
K
Yoneko
M
M
Wachi
M
M
D000818:Animals; D005947:Glucose / Q000009:adverse effects*; D006461:Hemolysis / Q000187:drug effects; D066298:In Vitro Techniques; D007262:Infusions, Intravenous / Q000009:adverse effects; D007552:Isotonic Solutions / Q000009:adverse effects*; D008297:Male; D010146:Pain / Q000139:chemically induced; D010689:Phlebitis / Q000139:chemically induced / Q000473:pathology; D011817:Rabbits; D000077331:Ringer's Solution; D013448:Sulfobromophthalein / Q000009:adverse effects; D014680:Veins / Q000187:drug effects / Q000473:pathology
D007552:Isotonic Solutions; C028570:Ringer's acetate; D013448:Sulfobromophthalein; D000077331:Ringer's Solution; D005947:Glucose