title: The Ki-67 index and survival in non-small cell lung cancer: a review and relevance to positron emission tomography.
abstract: OBJECTIVE
  We reviewed the current literature to discover the range of studies covering tissue-based and noninvasive methods for determining tumor stage and the prognostic value of staging in non-small cell lung cancer.
  
  
  METHODS
  Despite refinements in staging of non-small cell lung cancer, each stage remains heterogeneous because each stage contains patients who are at higher risk for recurrence than other patients within the same stage. Tissue-based and noninvasive methods have been investigated to complement tumor stage in assessing non-small cell lung cancer prognosis. The prognostic significance of tumor proliferation assessed by Ki-67 protein expression has been demonstrated in non-small cell lung cancer.
  
  
  RESULTS
  Recent positron emission tomography studies have also shown both prognostic value in non-small cell lung cancer uptake of [F-18] fluorodeoxyglucose (FDG) and correlation between non-small cell lung cancer FDG uptake and tumor proliferation.
  
  
  CONCLUSIONS
  We reviewed the prognostic significance of Ki-67 expression in non-small cell lung cancer and related it to positron emission tomography.
authors.affiliation: Department of Radiology, University of Washington Medical Center, Seattle 98195, USA.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Pugsley
authors.forename: Rodney A
authors.initials: RA
authors.lastname: Schmidt
authors.forename: Hubert
authors.initials: H
authors.lastname: Vesselle
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D008175:Lung Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D009367:Neoplasm Staging; D011379:Prognosis; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed / Q000379:methods
chemical_list: D000951:Antigens, Neoplasm; D019394:Ki-67 Antigen; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18