Bone turnover during distraction osteogenesis in an experimental sheep model.
Biochemical serum markers of osteoblastic activity and collagen turnover were measured in a sheep model of distraction osteogenesis. Significant increases of the bone formation marker osteocalcin were found during the first part of the consolidation phase and peaked at a time point equalling the distraction phase. Collagen turnover parameters pyridinoline and the specific type I collagen marker desoxypyridinoline consistently increased during the distraction and consolidation phases. While pyridinoline peaked at a time point similar to osteocalcin, desoxypyridinoline increased to a later stage in consolidation, indicating continuous turnover of bone-specific type I collagen. The results indicate a characteristic pattern of osteoblast cellular activation during distraction osteogenesis with possible consequences for the timing of treatment.
Windhagen
H
H
Department of Orthopaedic Surgery, Hannover Medical School, 30625 Hannover, Germany. windhagen@annastift.de
Witte
F
F
Hurschler
C
C
Maciejewski
O
O
Linnenberg
D
D
Thorey
F
F
D000596:Amino Acids / Q000652:urine; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D016723:Bone Remodeling; D002851:Chromatography, High Pressure Liquid; D003094:Collagen / Q000378:metabolism; D015675:Osteocalcin / Q000097:blood; D019857:Osteogenesis, Distraction; D011863:Radioimmunoassay; D012756:Sheep; D013977:Tibia / Q000601:surgery
D000596:Amino Acids; D015415:Biomarkers; D015675:Osteocalcin; C015484:pyridinoline; C036020:deoxypyridinoline; D003094:Collagen