A piperidine amide extracted from Piper longum L. fruit shows activity against Aedes aegypti mosquito larvae.
Mosquito larvicidal activity of Piper longum fruit-derived materials against the fourth-instar larvae of Aedes aegypti was examined. A crude methanol extract of P. longum fruits was found to be active against the larvae, and the hexane fraction of the methanol extract showed a strong larvicidal activity of 100% mortality. The biologically active component of P. longum fruits was characterized as pipernonaline by spectroscopic analyses. The LC(50) value of pipernonaline was 0.25 mg/L. The toxicity of pipernonaline is comparable to that of pirimiphos-methyl as a mosquito larvicide. In tests with available components derived from P. longum, no activity was observed with piperettine, piperine, or piperlongumine.
Yang
Young-Cheol
YC
Faculty of Biotechnology and Institute of Agricultural Science and Technology, College of Agriculture, Chonbuk National University, Chonju 561-756, South Korea.
Lee
Sang-Guei
SG
Lee
Hee-Kwon
HK
Kim
Moo-Key
MK
Lee
Sang-Hyun
SH
Lee
Hoi-Seon
HS
D000330:Aedes / Q000254:growth & development; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D005638:Fruit / Q000737:chemistry*; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification*; D007814:Larva; D000432:Methanol; D026321:Piperaceae / Q000737:chemistry*; D010880:Piperidines; D010936:Plant Extracts / Q000737:chemistry*
D000470:Alkaloids; D007306:Insecticides; D010880:Piperidines; D010936:Plant Extracts; C419151:pipernonaline; D000432:Methanol