title: Childhood discoid lupus erythematosus: report of five new cases and review of the literature.
abstract: Discoid lupus erythematosus (DLE) is an uncommon disease in childhood. In this paper we present five new cases of childhood DLE. Two of them are identical twin brothers, who developed similar lesions during an interval of 5 years. This is in favour of the hypothesis that both genetic factors and somatic mutations, due to environmental factors, are implicated in the pathogenesis. A review of the English language literature is also presented. In order to have better epidemiological data on this disease, all cases of childhood DLE, including those published in non-English literature and those not yet published, should be placed together and analysed.
authors.affiliation: Department of Paediatrics, O.L. Vrouw Hospital, Aalst, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Van Gysel
authors.forename: F B
authors.initials: FB
authors.lastname: de Waard-van der Spek
authors.forename: A P
authors.initials: AP
authors.lastname: Oranje
mesh_terms: D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D003879:Dermatologic Agents / Q000008:administration & dosage*; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000175:diagnosis* / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D009426:Netherlands; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents