title: Hydrogels formed by crosslinked poly(vinyl alcohol) as sustained drug delivery systems.
abstract: Poly(vinyl alcohol) was crosslinked with ethylene glycol diglycidyl ether to obtain hydrogel-forming polymers. The polymers were also substituted with oleoyl chloride, providing hydrogels with weak solubility. These new polymeric materials were evaluated for the formulation of sustained drug delivery systems. Vancomycin hydrochloride was used as a peptidic model drug whose sustained release should minimize its inactivation in the upper part of the gastrointestinal tract. Spray-dried mixtures of the drug and the polymer [at 1:4 and 1:8 (w:w) ratios] were prepared and the release of the drugs from the mixtures was evaluated in vitro at pH 2.0, 5.5, 7.4, and 8.0. The results indicated that the crosslinked polymers slowed down the release of the drugs with respect to the pure drug at each pH. The degree of crosslinking of ethylene glycol diglycidyl ether and the extent of substitution with oleoyl chloride were found to influence drug release.
authors.affiliation: Department of Pharmaceutical Sciences, Bologna University, Via S. Donato 19/2, 40127 Bologna, Italy. orienti@biocfarm.unibo.it
authors.forename: Isabella
authors.initials: I
authors.lastname: Orienti
authors.forename: R
authors.initials: R
authors.lastname: Treré
authors.forename: B
authors.initials: B
authors.lastname: Luppi
authors.forename: F
authors.initials: F
authors.lastname: Bigucci
authors.forename: T
authors.initials: T
authors.lastname: Cerchiara
authors.forename: G
authors.initials: G
authors.lastname: Zuccari
authors.forename: V
authors.initials: V
authors.lastname: Zecchi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D005079:Excipients; D020100:Hydrogels / Q000138:chemical synthesis*; D011142:Polyvinyl Alcohol / Q000138:chemical synthesis*; D012995:Solubility; D014640:Vancomycin / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D005079:Excipients; D020100:Hydrogels; D014640:Vancomycin; D011142:Polyvinyl Alcohol