title: Posttransplant lymphoproliferative disorders in lung transplant patients: the Cleveland Clinic experience.
abstract: PTLD is a well-recognized complication of organ transplantation. Large series of heart, renal, and liver transplants have been examined for the incidence and behavior of PTLD. However, reports of the incidence and characteristics of PTLDs in lung transplant (LTx) patients are few. We report our experience with PTLDs in a large series of LTx recipients at a single institution and compare them to other solid organ transplant recipient PTLDs seen at our institution. Twenty-eight patients were found to have PTLD, of whom 8 were lung transplant recipients. We evaluated nine PTLD specimens from these 8 patients for their histology, immunophenotype (CD20, CD3, EBV-LMP1), EBER status by in situ hybridization, and clinical features. The incidence of PTLD was 3.3% (8/244 patients). The time to development of PTLD, after transplant, was short (median time, 7 mo). All were of B-cell lineage. Overall, EBV was demonstrated in 77.7% (7 of 9 specimens) of PTLDs. All specimens tested for clonality were found to be monoclonal. Five patients died, with a median time to death of only 4.6 months. PTLDs in LTx patients are EBV-associated B-cell, predominantly monoclonal lymphoid lesions similar to other solid organ transplant PTLDs. Compared with other solid organ transplant recipients with PTLD at our institution, PTLDs in LTx patients have a propensity to involve the transplanted organ (P =.001, Fisher's exact test), occur earlier after transplant (P =.003, Wilcoxon test), and have a shorter survival (P =.002, log rank test). Reasons for this may include the relatively higher level of immunosuppression required in these patients and limited options in decreasing it. Although the incidence is low, careful early monitoring of lung transplantation patients is warranted because of the poor prognosis of patients developing this complication.
authors.affiliation: Department of Clinical Pathology, Cleveland Clinic Foundation, Ohio 44195, USA.
authors.forename: P
authors.initials: P
authors.lastname: Ramalingam
authors.forename: L
authors.initials: L
authors.lastname: Rybicki
authors.forename: M D
authors.initials: MD
authors.lastname: Smith
authors.forename: N A
authors.initials: NA
authors.lastname: Abrahams
authors.forename: R R
authors.initials: RR
authors.lastname: Tubbs
authors.forename: J
authors.initials: J
authors.lastname: Pettay
authors.forename: C F
authors.initials: CF
authors.lastname: Farver
authors.forename: E D
authors.initials: ED
authors.lastname: Hsi
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D018951:Antigens, CD20 / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D051925:CD79 Antigens; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D017403:In Situ Hybridization; D017730:Ki-1 Antigen / Q000032:analysis; D051917:Leukosialin; D016040:Lung Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000235:genetics; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012795:Sialoglycoproteins / Q000032:analysis; D015996:Survival Rate
chemical_list: D015703:Antigens, CD; D018951:Antigens, CD20; D051925:CD79 Antigens; C497881:CD79A protein, human; D017730:Ki-1 Antigen; D051917:Leukosialin; D012367:RNA, Viral; D011947:Receptors, Antigen, B-Cell; C465014:SPN protein, human; D012795:Sialoglycoproteins