Changes of zero-bending-moment states and structures of rat arteries in response to a step lowering of the blood pressure.
There are many papers on tissue remodeling of blood vessels in hypertension, but there are few documents describing the tissue remodeling of the blood vessels following a step lowering of the blood pressure. The present article presents data on the opening angle, the vessel wall thickness, and the thicknesses of the intima-media and adventitia layers of the blood vessels of the lower body (the abdominal aorta, and the common iliac, femoral, saphenous branch, medial plantar, and plantar metatarsal arteries) of the rat after a step lowering of the blood pressure and flow by a controlled constriction of the aorta below both renal arteries. We found a pattern of changes that depend on space (location on the vascular tree), time (after the blood pressure change), and the intensity of disturbance. We model mathematically the dynamics shown by the experimental results by means of the indicial response functions, which are defined as the morphometric changes in response to a step decrease of blood pressure or blood flow. Under the hypothesis that there is a range of linearity between the degree of tissue remodeling and the amplitude of the pressure change, we can use the indicial functions to predict the remodeling of the vessel under an arbitrary history of decreasing blood pressure; and conversely, we can compute the indicial response functions from pertinent results of a single experiment. The totality of all our experiments is consistent with the linearity hypothesis within the range of the experiment. The mathematical analysis and the formulas are presented in the Appendix.
Li
Zhuang-Jie
ZJ
Department of Bioengineering and Institute for Biomedical Engineering, University of California, San Diego, La Jolla 92093-0412, USA.
Huang
Wei
W
Fung
Yuan-Cheng
YC
D000818:Animals; D001158:Arteries / Q000166:cytology* / Q000503:physiopathology*; D001794:Blood Pressure; D003198:Computer Simulation; D004548:Elasticity; D018056:Hemorheology; D007022:Hypotension / Q000503:physiopathology*; D008297:Male; D008955:Models, Cardiovascular; D015233:Models, Statistical; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D033081:Shear Strength; D013314:Stress, Mechanical