title: Recent advances in understanding aminoglycoside ototoxicity and its prevention.
abstract: Studies over the last decade have left little doubt that reactive oxygen species (ROS) participate in the cellular events leading to aminoglycoside-induced hearing loss. The evidence ranges from the demonstration of aminoglycoside-mediated ROS formation in vitro to the prevention of ototoxicity by antioxidants in guinea pig in vivo. Here we review a hypothesis of the mechanism of toxicity, discuss possible causes underlying the gradient in base-to-apex sensitivity of outer hair cells, and present recent results on the adult mouse as a new animal model of aminoglycoside ototoxicity and its prevention.
authors.affiliation: Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Mich., USA.
authors.forename: Wei-Jing
authors.initials: WJ
authors.lastname: Wu
authors.forename: Su-Hua
authors.initials: SH
authors.lastname: Sha
authors.forename: Jochen
authors.initials: J
authors.lastname: Schacht
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D003638:Deafness / Q000139:chemically induced* / Q000378:metabolism; D005839:Gentamicins / Q000009:adverse effects*; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000378:metabolism; D007612:Kanamycin / Q000009:adverse effects*; D051379:Mice; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D017382:Reactive Oxygen Species; D007612:Kanamycin