title: Lembehsterols A and B, novel sulfated sterols inhibiting thymidine phosphorylase, from the marine sponge Petrosia strongylata.
abstract: Lembehsterols A (1) and B (2), two novel sulfated sterols, were isolated from the marine sponge Petrosia strongylata. Both sterols showed inhibitory activity against thymidine phosphorylase, which is an enzyme related to angiogenesis in solid tumors. The structures of these sulfated sterols were established on the basis of chemical and physicochemical evidence.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
authors.forename: Shunji
authors.initials: S
authors.lastname: Aoki
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Naka
authors.forename: Takuya
authors.initials: T
authors.lastname: Itoh
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Furukawa
authors.forename: Rachmaniar
authors.initials: R
authors.lastname: Rachmat
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Akiyama
authors.forename: Motomasa
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008386:Marine Biology; D011161:Porifera / Q000201:enzymology*; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013939:Thymidine Phosphorylase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D013261:Sterols; C464722:lembehsterol A; C464723:lembehsterol B; D013939:Thymidine Phosphorylase