Bicuculline attenuates the MLR-induced suppression of dorsal horn neurons receiving group III afferent input.
In decerebrate cats, we found that iontophoretic application of bicuculline, a GABA(A) receptor antagonist, attenuated the mesencephalic locomotor region-induced suppression of dorsal horn neurons responding to group III afferent input from the hindlimb. Our findings raise the possibility that GABA release onto dorsal horn neurons in the spinal cord may play an important role in the attenuation of the exercise pressor reflex by central command during exercise.
Degtyarenko
Alexandr M
AM
Division of Cardiovascular Medicine, Department of Internal Medicine and Human Physiology, University of California, 1 Shields Avenue, Davis, CA 95616, USA. amdegt@ucdavis.edu
Kaufman
Marc P
MP
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000344:Afferent Pathways / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002415:Cats; D004525:Efferent Pathways / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D004558:Electric Stimulation; D018756:GABA Antagonists / Q000494:pharmacology; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D020671:Posterior Horn Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D013681:Tegmentum Mesencephali / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013979:Tibial Nerve / Q000187:drug effects / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism* / Q000494:pharmacology
D018756:GABA Antagonists; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline