Effect of 7-nitroindazole on drug-priming reinstatement of D-methamphetamine-induced conditioned place preference.
The study investigated the role of nitric oxide (NO) in the relapse to drug-seeking behavior induced by D-methamphetamine. After the induction of D-methamphetamine (1 mg/kg) conditioned place preference, the rewarding effect became extinct 6 weeks later. The extinguished place preference was reinstated by D-methamphetamine (0.125 mg/kg) injection, an effect which was attenuated by 7-nitroindazole (12.5 and 25 mg/kg) pretreatment. The results demonstrate that NO is involved in relapse primed by D-methamphetamine injection.
Li
Su-Min
SM
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Beijing 100083, PR China.
Ren
Yan-Hua
YH
Zheng
Ji-Wang
JW
D019969:Amphetamine-Related Disorders / Q000523:psychology*; D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects*; D006702:Homing Behavior / Q000187:drug effects; D007191:Indazoles / Q000494:pharmacology*; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052248:Nitric Oxide Synthase Type I; D051381:Rats; D017207:Rats, Sprague-Dawley; D012008:Recurrence; D013237:Stereoisomerism
D007191:Indazoles; D009569:Nitric Oxide; D008694:Methamphetamine; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496322:Nos1 protein, rat; C080122:7-nitroindazole