title: Developmental expression pattern of oncostatin M receptor beta in mice.
abstract: Oncostatin M (OSM), which is predominantly expressed in bone marrow, is a member of the interleukin-6 family of cytokines, and appears to play important roles in hematopoiesis and the development of the liver. Recently, specific beta subunit of OSM receptor (OSMRbeta) was isolated from LO cells originated from aorta-gonad-mesonephros (AGM) region. In this study, we performed in situ hybridization to explore the expression pattern of OSMRbeta during murine embryogenesis, postnatal development, and in adult tissues. At 11.5 days postcoitum (dpc), the expression of OSMRbeta was first detected in aortic endothelial cells of the AGM region. At 14.5dpc, its gene expression was clearly observed in the primordia of some organs, including liver, thymus, choroid plexus, and limb, and persisted into postnatal mice. After birth, its gene expression became detectable in the other organs, such as lymph node, bone, heart, kidney, small intestine, nasal cavity, and lung.
authors.affiliation: Department of Anatomy and Neurobiology, Wakayama Medical University, 811-1 Kimiidera, 641-0012 Wakayama, Japan.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Tamura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Morikawa
authors.forename: Minoru
authors.initials: M
authors.lastname: Tanaka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miyajima
authors.forename: Emiko
authors.initials: E
authors.lastname: Senba
mesh_terms: D000818:Animals; D015870:Gene Expression; D020869:Gene Expression Profiling; D008198:Lymph Nodes / Q000196:embryology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger; D018121:Receptors, Cytokine / Q000235:genetics*; D053677:Receptors, Oncostatin M; D013154:Spleen / Q000196:embryology / Q000378:metabolism; D013950:Thymus Gland / Q000196:embryology / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D012333:RNA, Messenger; D018121:Receptors, Cytokine; D053677:Receptors, Oncostatin M