Late course accelerated hyperfractionation radiotherapy concomitant with cisplatin in patients with esophageal carcinoma.
The purpose of this study was to examine whether combined cisplatin and late course accelerated fractionation radiotherapy (LCAH) (the combined group) can confer a better outcome over LCAH alone in treating esophageal carcinoma. Eighty-one eligible patients were randomly entered into two groups: the LCAH alone group, and the combined group. There was a better outcome in the combined group compared to the LCAH group, but the difference was not significant. The combined therapy could significantly improve the survival rate and local control of the disease in the early stage, but not in the advanced stage, because of the possibility of invasion. More severe complications occurred in the combined group than in the LCAH group, but they were within tolerance. In conclusion, LCAH concomitant with cisplatin could improve the survival of patients with esophageal cancer, especially in the early stage, as long as the side effects of the treatment are within tolerable limits.
Gao
Xian-Shu
XS
Department of Radiation Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, P.R. China.
Qiao
Xue-Ying
XY
Yang
Xiang-Ran
XR
Asaumi
Jun-Ichi
J
Zhou
Zhi-Guo
ZG
Wang
Ya-Di
YD
Zhou
Dao-An
DA
Wan
Jun
J
Kuroda
Masahiro
M
Kishi
Kanji
K
Kawasaki
Shoji
S
Hiraki
Yoshio
Y
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy; D009367:Neoplasm Staging; D015996:Survival Rate
D000970:Antineoplastic Agents; D002945:Cisplatin