title: Treatment of active unicameral bone cysts with percutaneous injection of demineralized bone matrix and autogenous bone marrow.
abstract: BACKGROUND
  The treatment of unicameral bone cysts varies from open bone-grafting procedures to percutaneous injection of corticosteroids or bone marrow. The purpose of this study was to evaluate the feasibility and effectiveness of percutaneous injection of a mixture of demineralized bone matrix and autogenous bone marrow for the treatment of simple bone cysts.
  
  
  METHODS
  Twenty-three patients with an active unicameral bone cyst were treated with trephination and injection of allogeneic demineralized bone matrix and autogenous bone marrow. The patients were followed for an average of fifty months (range, thirty to eighty-one months), at which time pain, function, and radiographic signs of resolution of the cyst were assessed.
  
  
  RESULTS
  The average time until the patients had pain relief was five weeks, and the average time until the patients returned to full, unrestricted activities was six weeks. Bone-healing at the site of the injection was first seen radiographically at three to six months. No patient had a pathologic fracture during this early bone-healing stage. Cortical remodeling was seen radiographically by six to nine months, and after one year the response was usually complete, changing very little from then on. Five patients required a second injection because of recurrence of the cyst, and all five had a clinically and radiographically quiescent cyst after an average of thirty-six additional months of follow-up. Seven of the twenty-three patients had incomplete healing manifested by small, persistent radiolucent areas within the original cyst. None of these cysts increased in size or resulted in pain or fracture.
  
  
  CONCLUSIONS
  Percutaneous injection of allogeneic demineralized bone matrix and autogenous bone marrow is an effective treatment for unicameral bone cysts.
authors.affiliation: Orthopaedics Indianapolis, Indiana 46278, USA.
authors.forename: Bruce T
authors.initials: BT
authors.lastname: Rougraff
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Kling
mesh_terms: D000293:Adolescent; D001845:Bone Cysts / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D016026:Bone Marrow Transplantation / Q000379:methods*; D001857:Bone Matrix; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005269:Femur; D005500:Follow-Up Studies; D006801:Humans; D006811:Humerus; D007271:Injections, Intradermal; D008297:Male; D011859:Radiography; D012189:Retrospective Studies; D014182:Transplantation, Autologous; D016896:Treatment Outcome