The anaphase-promoting complex: proteolysis in mitosis and beyond.
Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and cyclins and thereby targets them for destruction by the 26S proteasome.
Peters
Jan-Michael
JM
Research Institute of Molecular Pathology, Dr.-Bohr Gasse 7, A-1030 Vienna, Austria. peters@imp.univie.ac.at
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism; D016213:Cyclins / Q000502:physiology; D010450:Endopeptidases; D008025:Ligases / Q000502:physiology*; D008938:Mitosis / Q000502:physiology*; D010447:Peptide Hydrolases / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D064247:Separase; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000502:physiology; D043743:Ubiquitin-Protein Ligase Complexes; D014452:Ubiquitins / Q000378:metabolism
D018797:Cell Cycle Proteins; D016213:Cyclins; D016212:Transforming Growth Factor beta; D014452:Ubiquitins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D010450:Endopeptidases; D010447:Peptide Hydrolases; D064247:Separase; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease; D008025:Ligases