title: Fornix and conjunctiva reconstruction by amniotic membrane in a patient with conjunctival mucosa-associated lymphoid tissue lymphoma.
abstract: BACKGROUND
  Conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma is a rare, low-grade, non-Hodgkin's B-cell lymphoma. Herein, we report our successful management of the large conjunctival defect caused by resection of conjunctival MALT lymphoma by covering it with transplanted amniotic membrane.
  
  
  METHODS
  A 28-year-old Japanese man, who had been diagnosed histologically as having conjunctival MALT lymphoma in his left eye, was referred to us for treatment. The tumor was located on the lower bulbar and palpebral conjunctiva, and involved the fornix. Extensive resection of the conjunctival lesion was performed. Two pieces of amniotic membrane were used to reconstruct the fornix, bulbar, and palpebral conjunctival defect.
  
  
  METHODS
  Epithelialization over the transplantation was completed within 3 weeks when all sutures were removed. During the 6 months of follow-up, there was no recurrence or any postoperative complication, such as graft rejection, symblepharon, or chronic inflammation.
  
  
  CONCLUSIONS
  We demonstrated for the first time that amniotic membrane can be used to cover a large defect on both bulbar and palpebral conjunctiva when such a low-grade malignancy as MALT lymphoma is extensively excised. Amniotic membrane transplantation was quite effective for the fornix and conjunctival reconstruction.
authors.affiliation: Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kobayashi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Takahira
authors.forename: Akihisa
authors.initials: A
authors.lastname: Yamada
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Segawa
authors.forename: Toshiro
authors.initials: T
authors.lastname: Tanahashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shirao
authors.forename: Akitaka
authors.initials: A
authors.lastname: Nonomura
mesh_terms: D000328:Adult; D000650:Amnion / Q000637:transplantation*; D003230:Conjunctival Neoplasms / Q000473:pathology / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology / Q000601:surgery*; D008297:Male; D013508:Ophthalmologic Surgical Procedures; D019651:Plastic Surgery Procedures / Q000379:methods*; D016896:Treatment Outcome