title: Total synthesis of pyridovericin: studies toward the biomimetic synthesis of pyridomacrolidin.
abstract: [reaction: see text] The total synthesis of the novel metabolite pyridovericin 1 is reported. The synthesis of this key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2 has been accomplished in good yield from readily available 2,4-dihydroxypyridine.
authors.affiliation: Dyson Perrins Laboratory, Oxford University, South Parks Road, Oxford OX1 3QY, UK. jack.baldwin@chem.ox.ac.uk
authors.forename: Jack E
authors.initials: JE
authors.lastname: Baldwin
authors.forename: Robert M
authors.initials: RM
authors.lastname: Adlington
authors.forename: Aurelia
authors.initials: A
authors.lastname: Conte
authors.forename: Nageswara Rao
authors.initials: NR
authors.lastname: Irlapati
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Marquez
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Pritchard
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D005658:Fungi / Q000737:chemistry; D018716:Molecular Mimicry; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D011728:Pyridones; C114117:pyridomacrolidin; C114116:pyridovericin; D011505:Protein-Tyrosine Kinases