Analogous cytokine responses to Burkholderia pseudomallei strains contrasting in virulence correlate with partial cross-protection in immunized mice.
Cytokine mRNA levels were assessed in Burkholderia pseudomallei-susceptible BALB/c mice and B. pseudomallei-resistant C57BL/6 mice following administration of a sublethal dose of less virulent (LV) B. pseudomallei, a candidate immunogen tested for protection against a highly virulent (HV) challenge. Compared on the basis of the bacterial loads, the cytokine patterns induced by HV and LV B. pseudomallei were similar, involving gamma interferon, interleukin-10, and other cytokines. Partial cross-protection between B. pseudomallei strains is shown to be associated with cytokine profiles involving both type 1 and type 2 cytokines.
Ulett
Glen C
GC
Department of Microbiology and Immunology, School of Medicine, James Cook University, Townsville, Queensland, Australia 4811. Glen.Ulett@stjude.org
Ketheesan
Natkunam
N
Clair
Timothy W
TW
McElnea
Catriona L
CL
Barnes
Jodie L
JL
Hirst
Robert G
RG
D000818:Animals; D016957:Burkholderia pseudomallei / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity; D003429:Cross Reactions; D016207:Cytokines / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D008099:Liver / Q000276:immunology / Q000382:microbiology; D008554:Melioidosis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000276:immunology / Q000382:microbiology; D014611:Vaccination; D014774:Virulence
D016207:Cytokines