title: Management of the urethral outlet in patients with severe prolapse.
abstract: OBJECTIVE
  Numbers of women seeking consultation for pelvic floor disorders, a large portion of which will involve pelvic organ prolapse (POP) and lower urinary tract dysfunction, are expected to reach epidemic proportions within the next decade. A full understanding of the complex impact of pelvic organ prolapse on lower urinary tract function is crucial to successful management.
  
  
  RESULTS
  Recent data lend support to the concept that women with POP, but no associated urethral dysfunction, may be best served by a surgical repair that carefully avoids dissection in the periurethral area. Conversely, preoperative evaluation will often reveal bladder outlet obstruction concomitant with 'hidden', 'potential', or 'occult' stress urinary incontinence when the prolapse is reduced. Many of these women will not have incontinence symptoms in daily life. Paradoxically, the mechanical bladder outlet obstruction may induce detrusor instability with subsequent obstructed/overactive bladder symptom complexes not dissimilar to those of men with prostatic bladder outlet obstruction. Anatomic research shows that the vessels and nerves supplying the urethra are particulary vulnerable to surgical techniques used in pelvic organ prolapse repair.
  
  
  CONCLUSIONS
  This mix of obstructed, overactive bladder with hidden stress incontinence increases with degree of POP, and all women with severe prolapse will fair best if evaluated for all three conditions prior to surgical repair.
authors.affiliation: Obstetrics and Gynecology, Weill Cornell Medical Center, New York Presbyterian Hospital, New York, New York, USA. LJRomanziMD@aol.com
authors.forename: Lauri J
authors.initials: LJ
authors.lastname: Romanzi
mesh_terms: D003094:Collagen / Q000378:metabolism; D045166:Estradiol Congeners / Q000627:therapeutic use; D005260:Female; D006801:Humans; D011391:Prolapse; D001748:Urinary Bladder Neck Obstruction / Q000150:complications / Q000601:surgery; D014550:Urinary Incontinence, Stress / Q000150:complications / Q000503:physiopathology / Q000601:surgery* / Q000628:therapy; D014563:Urodynamics; D014570:Urologic Diseases / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D014596:Uterine Prolapse / Q000150:complications / Q000503:physiopathology / Q000601:surgery
chemical_list: D045166:Estradiol Congeners; D003094:Collagen