title: [Risk factors of transient cerebral ischemic episodes: hyperfibrinogenemia and carotid histopathology].
abstract: Risk factors may play a fundamental role in the evolution from a stable to a vulnerable plaque. In particular, the hyperfibrinogenemia, independently from other risk factors, influences the natural history of cerebrovascular disease modifying the histologic composition of atherosclerotic plaques and precipitates carotid thrombosis resulting from rupture of the plaque. Determination of plasma fibrinogen may help to identify a subset of patients at high risk for a rapid progression of carotid atherosclerosis and related clinical events. We suggest that these patients may benefit of an earlier surgical intervention even if the degree of carotid stenosis is not severe.
authors.forename: Luigi Giusto
authors.initials: LG
authors.lastname: Spagnoli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mauriello
authors.forename: Stefano
authors.initials: S
authors.lastname: Fratoni
authors.forename: Lucia
authors.initials: L
authors.lastname: Anemona
authors.forename: Elena
authors.initials: E
authors.lastname: Bonanno
mesh_terms: D001161:Arteriosclerosis / Q000150:complications*; D002340:Carotid Artery Diseases / Q000150:complications*; D005340:Fibrinogen / Q000378:metabolism*; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000209:etiology*; D012307:Risk Factors
chemical_list: D005340:Fibrinogen
vernacular_title: Fattori di rischio degli episodi ischemici cerebrali transitori: iperfibrinogenemia e istopatologia carotidea.