A time-to-treatment analysis in the medicine versus angiography in thrombolytic exclusion (MATE) trial.
Patients with acute coronary syndromes who are considered ineligible for thrombolytic therapy are at high risk of recurrent ischemia and death. This trial randomized 201 patients to triage angiography in the first 24 hours of hospital admission versus conventional medical care. Of the 165 patients who underwent angiography that was either protocol-driven or on the basis of physician preference, those who underwent angiography within 6 hours of symptom onset had a reduction in early and late adverse events. The rates of in-hospital recurrent ischemia were 15.4%, 15.4%, 17.5%, 32.4%, and 38.5%, respectively (P = 0.01 for trend), and rates of cumulative recurrent myocardial infarction or death were 0%, 12.8%, 10.0%, 11.8%, and 7.7%, respectively (P = 0.48 for trend) for patients who underwent angiography at 0-6, 6-12, 12-24, 24-48, and over 48 hours, respectively from symptom onset. Future trials of invasive versus conservative therapy should focus on performing angiography within 6 hours of symptom onset.
McCullough
P A
PA
University of Missouri-Kansas City School of Medicine, Truman Medical Center, 2301 Holmes Street, Kansas City, MO 64108, USA. mcculloughp@umkc.edu
O'Neill
W W
WW
Graham
M
M
Stomel
R J
RJ
Rogers
F
F
David
S
S
Farhat
A
A
Kazlauskaite
R
R
al-Zagoum
M
M
Grines
C L
CL
D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000628:therapy*; D018579:Patient Selection; D011446:Prospective Studies; D015912:Thrombolytic Therapy; D013997:Time Factors