[The effect of anthocyanins from Aronii melanocarpa and acetylcysteine on selected after-effects of lead acetate poisoning].
In recent years we have widely examined the results of protracted exposures on lead. Lead mostly shows that it accumulates in bones in an insoluble phosphate form. In much of the experimental research we observed that lead can cause reactive forms of oxygen and oxidative stress. The examination was carried out on 40 female and male Wistar rats weighing 200-250 g. They lived in the animal quarters with a stable temperature and humidity. They were fed with standard fodder (Murigan) and water ad libitum. In the work carried out the effect of anthocyanins of Aronia Melanocarpa Elliot and acetylcysteine on the selected parameters of oxidative stress of experimental animals with chronic lead acetate poisoning were examined. After administration anthocyanins substantially decreased the concentration of unsaturated fatty acid peroxidation and carbonyls in blood serum. At the same time we observed a significant decrease of 8-hydroxy-2'-deoxyguanosine in urine. Antocyanins from Aronia Melanocarpa appear to be a good substance for the diminishing of oxidative stress, these results caused with long-term administration of lead acetate.
Kowalczyk
Edward
E
Zakład Farmakologii Instytutu Nauk Podstawowych Wojskowej Akademii Medycznej w Łodzi.
Jankowski
Andrzej
A
Niedworok
Jan
J
Smigielski
Jan
J
Jankowska
Beata
B
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D000872:Anthocyanins; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005260:Female; D007529:Isoflavones / Q000494:pharmacology*; D007855:Lead Poisoning / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009942:Organometallic Compounds / Q000506:poisoning*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D000872:Anthocyanins; D005231:Fatty Acids, Unsaturated; D007529:Isoflavones; D009942:Organometallic Compounds; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; C008261:lead acetate; D000111:Acetylcysteine
Wpływ antocyjanin z Aronii czarnoowocowej i acetylcysteiny na wybrane nastepstwa zatrucia octanem ołowiu.