title: High doses of riboflavin and thiamine may help in secondary prevention of hyperlactatemia.
abstract: Lactic acidosis is the most dramatic manifestation of nucleoside reverse transcriptase inhibitor (NRTI)-associated mitochondrial dysfunction. The optimal management of subjects who recover from an episode of lactic acidosis--or its milder form, symptomatic hyperlactatemia--remains unclear. Most physicians opt to restart NRTI-sparing regimens, but such an option may not be available for heavily antiretroviral-experienced patients. Therefore, there is a need to investigate ways to prevent the recurrence of hyperlactatemia in patients who require NRTI-based therapy.
authors.affiliation: Pediatric Infectious Diseases Division, Rainbow Babies and Children's Hospital, Western Reserve University, Cleveland, USA.
authors.forename: Grace A
authors.initials: GA
authors.lastname: McComsey
authors.forename: Michael M
authors.initials: MM
authors.lastname: Lederman
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced / Q000517:prevention & control*; D000328:Adult; D000368:Aged; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects*; D012256:Riboflavin / Q000627:therapeutic use*; D013831:Thiamine / Q000627:therapeutic use*
chemical_list: D018894:Reverse Transcriptase Inhibitors; D012256:Riboflavin; D013831:Thiamine