Anti-inflammatory agent, dexamethasone, does not affect exercise-induced arterial hypoxemia in Thoroughbreds.
In view of the suggestion that pulmonary injury-induced release of histamine and/or other chemical mediators from airway inflammatory and mast cells contribute to the exercise-induced arterial hypoxemia (EIAH) in human athletes, we examined the effects of pretreatment with a potent anti-inflammatory agent, dexamethasone, on EIAH and desaturation of hemoglobin in horses. Seven healthy, sound, exercise-trained Thoroughbreds were studied in the control (no medications) experiments, followed in 7 days by intravenous dexamethasone (0.11 mg.kg(-1).day(-1) for 3 consecutive days) studies. Blood-gas measurements were made at rest and during incremental exercise leading to maximal exertion at 14 m/s on a 3.5% uphill grade. Galloping at this workload induced pulmonary hemorrhage in all horses in both treatments, thereby indicating that stress failure of pulmonary capillaries had occurred. In both treatments, significant EIAH, desaturation of hemoglobin, hypercapnia, acidosis, and hyperthermia developed during maximal exercise, but significant differences between the control and dexamethasone treatments were not discerned. The failure of pretreatment with dexamethasone to significantly affect EIAH suggests that pulmonary injury-evoked airway inflammatory response may not play a major role in EIAH in racehorses. However, our observations in both treatments that EIAH developed quickly (being evident at 30 s of exertion) and that its severity remained unaffected by increasing exercise duration (to 120 s) suggest that EIAH has a functional basis, probably related to significant shortening of the transit time for blood in the pulmonary capillaries as cardiac output increases dramatically.
Manohar
Murli
M
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 61801, USA. mmanohar@uiuc.edu
Goetz
Thomas E
TE
Hassan
Aslam S
AS
Depuy
Tracy
T
Humphrey
Sarah
S
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006736:Horses / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000097:blood*; D019344:Lactic Acid / Q000097:blood; D007828:Laryngoscopy; D008297:Male; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*; D014132:Trachea / Q000502:physiology
D000893:Anti-Inflammatory Agents; D006454:Hemoglobins; D002245:Carbon Dioxide; D019344:Lactic Acid; D003907:Dexamethasone; D010100:Oxygen