title: A case of imported paracoccidioidomycosis in a German legionnaire.
abstract: We report on a case of the chronic form of paracoccidioidomycosis with swelling and ulcerations of the mouth in a German legionnaire who also suffered from a chronic bronchitis. The patient had worked for many years in Brazil, an area endemic for the disease. Infection due to Paracoccidioides brasiliensis was diagnosed in Germany, more than 10 years after the patient's return. Diagnosis was established by the presence of yeast cells with multipolar budding in the tissue of the oral lesion. Furthermore, the fungus was grown in a liquid Leishmania culture medium. Identification of the fungus was based on morphology and genetic sequencing. Furthermore, IgG antibodies against a 43-kDa antigen of P. brasiliensis were detected in a western blot. After itraconazole therapy (400 mg day(-1)) for 4 weeks, the lesions had disappeared almost completely, but the therapy was continued for further 5 months to avoid relapse of the infection.
authors.affiliation: Institute for Medical Microbiology, Bonn, Germany. regine.horre@gmx.de
authors.forename: R
authors.initials: R
authors.lastname: Horré
authors.forename: G
authors.initials: G
authors.lastname: Schumacher
authors.forename: K
authors.initials: K
authors.lastname: Alpers
authors.forename: H M
authors.initials: HM
authors.lastname: Seitz
authors.forename: S
authors.initials: S
authors.lastname: Adler
authors.forename: K
authors.initials: K
authors.lastname: Lemmer
authors.forename: G S
authors.initials: GS
authors.lastname: De Hoog
authors.forename: K P
authors.initials: KP
authors.lastname: Schaal
authors.forename: K
authors.initials: K
authors.lastname: Tintelno
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D000946:Antigens, Fungal / Q000032:analysis*; D015153:Blotting, Western; D029481:Bronchitis, Chronic / Q000150:complications; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000150:complications / Q000382:microbiology; D010228:Paracoccidioides / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D010229:Paracoccidioidomycosis / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000935:Antifungal Agents; D000946:Antigens, Fungal; D007074:Immunoglobulin G; D017964:Itraconazole