The epigenesis of planum temporale asymmetry in twins.
Variation in hemispheric asymmetry of the planum temporale (PT) has been related to verbal ability. The degree to which genetic and environmental factors mediate PT asymmetry is not known. This study examined the heritability for planar asymmetry in 12 dizygotic (DZ) and 27 monozygotic (MZ) male twin pairs who were between 6 and 16 years of age. There was weak but positive evidence for heritability of planar asymmetry. Co-twin similarity for planar asymmetry and Sylvian fissure morphology increased when excluding twins discordant for writing hand and when excluding twins exhibiting birth weight differences >20% from the analyses. Birth weight differences were also related to twin differences in total cerebral volume, but not central sulcus asymmetry. These results suggest that exogenous perinatal factors affect the epigenesis of planar asymmetry development.
Eckert
Mark A
MA
Department of Neuroscience, McKnight Brain Institute of the University of Florida, Gainesville, FL 32610, USA. eckert@ufl.edu
Leonard
Christiana M
CM
Molloy
Elizabeth A
EA
Blumenthal
Jonathan
J
Zijdenbos
Alex
A
Giedd
Jay N
JN
D000293:Adolescent; D001724:Birth Weight; D002540:Cerebral Cortex / Q000002:abnormalities / Q000033:anatomy & histology / Q000254:growth & development; D002648:Child; D007839:Functional Laterality / Q000235:genetics*; D006801:Humans; D007806:Language Disorders / Q000209:etiology*; D008297:Male; D012307:Risk Factors; D013702:Temporal Lobe / Q000002:abnormalities / Q000033:anatomy & histology / Q000254:growth & development; D014427:Twins / Q000235:genetics*; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics