Patavine, a new arylnaphthalene lignan glycoside from shoot cultures of Haplophyllum patavinum.
A new arylnaphthalene lignan glycoside, patavine (1), together with five known lignans, justicidin B (2), diphyllin (3), tuberculatin (4), majidine (5), and arabelline (6) were isolated from shoot cultures of Haplophyllum patavinum. The structure of the new compound was elucidated by extensive one-dimensional (1D) and two-dimensional (2D) NMR experiments and mass spectrometry. The cytotoxicity of compounds 1, and 3-6 against LoVo human colon carcinoma cells was investigated.
Innocenti
Gabbriella
G
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Padova, Italy. gabbriella.innocenti@unipd.it
Puricelli
Lucia
L
Piacente
Sonia
S
Caniato
Rosy
R
Filippini
Raffaella
R
Cappelletti
Elsa Mariella
EM
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027821:Rutaceae / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006027:Glycosides; D017705:Lignans; D009281:Naphthalenes; C464728:patavine