[The effect of inhaled low molecular weight heparin on cell composition in bronchoalveolar lavage fluid and serum levels of soluble receptor IL-2 in bronchial asthma patients].
The 17 asthmatics were studied. The patients were administered LMWH inhalations during two weeks in a day dose 5000 IU anti-Xa. The cell composition in BALF and serum levels of sIL-2R were estimated before and two weeks after treatment. We found that LMWH changed significantly cell BALF profile, decreased the number of inflammatory cells (p < 0.005) but did not change serum sIL-2R concentrations (p < 0.13). Baseline serum levels of sIL-2R were normal (73.9 +/- 26.6 U/ml) according to producer's norm.
Passowicz-Muszyńska
Ewa
E
Katedra i Klinika Chorób Płuc Akademii Medycznej we Wrocławiu.
Jankowska
Renata
R
Krasnowska
Maryla
M
D000280:Administration, Inhalation; D000328:Adult; D001249:Asthma / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D008875:Middle Aged
D006495:Heparin, Low-Molecular-Weight; D007376:Interleukin-2
Wpływ inhalacji drobnoczasteczkowej heparyny na skład komórkowy popłuczyn oskrzelowo-pecherzykowych i stezenie rozpuszczalnego receptora dla IL-2 w surowicy chorych na astme oskrzelowa.