title: Combination antipsychotics: pros, cons, and questions.
abstract: In prescription surveys, use of combination antipsychotics is common and is increasing, despite little supporting evidence. This article highlights potential problems with using combination antipsychotics, discusses paths to their maintenance use, and reviews the efficacy evidence. Paths to maintenance antipsychotic combinations include (1) failure or patient refusal of all reasonable monotherapies, (2) indefinite continuation of combinations initially intended to be brief, (3) trials of combinations in preference to reasonable monotherapy trials, and (4) addition of a second antipsychotic to counteract a problem (safety, tolerability, or adherence) arising during successful monotherapy. Virtually all of the evidence on combination antipsychotics is on augmentation of clozapine, with only one randomized controlled trial. Research on combination antipsychotics is sorely needed. Designing clinical trials is made difficult by the very large numbers of possible combinations and doses. It may be feasible to analyze existing data bases to identify combinations that appear particularly promising to investigate.
authors.affiliation: Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229-3900, USA. millera@uthscsa.edu
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Miller
authors.forename: Catherine S
authors.initials: CS
authors.lastname: Craig
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects; D019091:Critical Pathways; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine