title: Patavine, a new arylnaphthalene lignan glycoside from shoot cultures of Haplophyllum patavinum.
abstract: A new arylnaphthalene lignan glycoside, patavine (1), together with five known lignans, justicidin B (2), diphyllin (3), tuberculatin (4), majidine (5), and arabelline (6) were isolated from shoot cultures of Haplophyllum patavinum. The structure of the new compound was elucidated by extensive one-dimensional (1D) and two-dimensional (2D) NMR experiments and mass spectrometry. The cytotoxicity of compounds 1, and 3-6 against LoVo human colon carcinoma cells was investigated.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Padova, Italy. gabbriella.innocenti@unipd.it
authors.forename: Gabbriella
authors.initials: G
authors.lastname: Innocenti
authors.forename: Lucia
authors.initials: L
authors.lastname: Puricelli
authors.forename: Sonia
authors.initials: S
authors.lastname: Piacente
authors.forename: Rosy
authors.initials: R
authors.lastname: Caniato
authors.forename: Raffaella
authors.initials: R
authors.lastname: Filippini
authors.forename: Elsa Mariella
authors.initials: EM
authors.lastname: Cappelletti
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027821:Rutaceae / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D017705:Lignans; D009281:Naphthalenes; C464728:patavine