Serum malondialdehyde correlates with therapeutic efficiency of high activity antiretroviral therapies (HAART) in HIV-1 infected children.
Serum malondialdehyde (MDA) levels are increased in human immunodeficiency virus (HIV)-infected children, as it happens also in infected adult individuals. Introduction of high activity antiretroviral therapy (HAART) has promoted an intense decline in morbidity and mortality of these patients. Here we present data on the effect of HAART on serum MDA of HIV+ children and compare them with levels prior to HAART. MDA levels reflect, as other markers do, the HAART-induced clinical improvement and probably also the pro-oxidant/antioxidant side effects of the different drugs used. The results herein allow the proposal of including serum MDA levels as an additional parameter for the clinical management of HIV+ children.
Jareño
Enrique J
EJ
Servicio de Pediatría, Hospital Clínico Universitario, Valencia, Spain.
Romá
Joaquín
J
Romero
Belén
B
Marín
Nuria
N
Muriach
María
M
Johnsen
Siv
S
Bosch-Morell
Francisco
F
Marselou
Lena
L
Romero
Francisco J
FJ
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D015415:Biomarkers / Q000097:blood*; D002648:Child; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress
D019380:Anti-HIV Agents; D015415:Biomarkers; D008315:Malondialdehyde