Paraoxonase Gln-Arg(192) and Leu-Met(55) gene polymorphisms and enzyme activity in a population with a low rate of coronary heart disease.
OBJECTIVE
To assess whether paraoxonase (PON1) polymorphisms at positions 55 and 192 and/or their phenotypic expressions influence the risk of myocardial infarction (MI) in Spanish population.


METHODS
Two hundred and fifteen male survivors of a MI and their age-matched controls were included in the study. Lipids, apolipoproteins (apo) A-I and B, PON1 activity on paraoxon and phenylacetate and PON1 polymorphisms were determined.


RESULTS
Genotype distribution was similar in patients and controls. Enzyme activities were lower in patients, but multiple logistic regression analysis did not show any independent association with a higher risk of MI.


CONCLUSIONS
None of the PON1 polymorphisms or their corresponding measured activities are independent risk factors for MI in our population.
Ferré
Natàlia
N
Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Reus, Spain.
Tous
Mònica
M
Paul
Antoni
A
Zamora
Alberto
A
Vendrell
Juan J
JJ
Bardají
Alfredo
A
Camps
Jordi
J
Richart
Cristobal
C
Joven
Jorge
J
D000368:Aged; D019943:Amino Acid Substitution; D043303:Aryldialkylphosphatase; D003327:Coronary Disease / Q000201:enzymology / Q000453:epidemiology* / Q000235:genetics; D004950:Esterases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors
D004950:Esterases; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human