The effects of hypertonic saline solution (7.5%) on coagulation and fibrinolysis: an in vitro assessment using thromboelastography.
We studied the effects of hypertonic (7.5%) and normal saline on coagulation and fibrinolysis in an in vitro model using thromboelastography of human whole blood. Reaction times increased and alpha angles decreased with hypertonic saline replacement at 7.5% blood volume compared with similar dilution with normal saline. At 10% blood volume replacement with hypertonic saline, reaction and coagulation times were significantly increased and alpha angles were decreased. Clot lysis at 30 min was also significantly reduced. We conclude that 7.5% hypertonic saline solution has anticoagulant effects if it replaces 7.5% or more of blood volume.
Tan
T S
TS
Department of Anaesthesia, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074.
Tan
K H S
KH
Ng
H P
HP
Loh
M W
MW
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D005440:Fluid Therapy; D006801:Humans; D008297:Male; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology; D013916:Thrombelastography
D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride