Alcohol differentially affects c-Fos expression in the supraoptic nucleus of long-sleep and short-sleep mice.
Ethanol administration in long-sleep (LS) and short-sleep (SS) mice results in a large number of Fos-IR neurons in the supraoptic nucleus (SON) in LS, and almost no Fos-IR neurons in the same nucleus in SS mice. In contrast, isotonic saline, hypertonic saline, with or without ethanol, resulted in a similar pattern of Fos-IR in both strains. These data indicate a differential effect of ethanol on c-Fos signaling specifically in the SON. Since the LS and SS mice were specifically selected for differential sensitivity to the sedative/hypnotic effects of ethanol, this differential in c-Fos activity may be causally implicated in their differential sensitivity to ethanol.
Eisenman
Leonard M
LM
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19017, USA. leonard.eisenman@mail.tju.edu
Donovan
H Scott
HS
Johnson
Thomas E
TE
D020268:Alcohol-Induced Disorders, Nervous System / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001127:Arginine Vasopressin / Q000096:biosynthesis / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects / Q000502:physiology; D015536:Down-Regulation / Q000187:drug effects / Q000502:physiology; D004361:Drug Tolerance / Q000235:genetics*; D000431:Ethanol / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000187:drug effects* / Q000378:metabolism; D012890:Sleep / Q000187:drug effects* / Q000235:genetics; D013495:Supraoptic Nucleus / Q000187:drug effects* / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects / Q000502:physiology; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
D002492:Central Nervous System Depressants; D016760:Proto-Oncogene Proteins c-fos; D001127:Arginine Vasopressin; D000431:Ethanol