title: Collision-induced signal enhancement (CISE): the use of boundary activation to effect non-resonant CISE.
abstract: An alternative to resonant excitation collision-induced signal enhancement (CISE) is presented. This alternative utilizes boundary activation instead of resonant excitation to effect CISE and is called boundary activated collision induced signal enhancement (BA-CISE). There are three ways to effect BA-CISE to enhance the signal for an MS(n+1) experiment. Each technique utilizes the beta(z) = 0 boundary, which ions encounter from high to low mass/charge ratio. BA-CISE is shown to produce an almost 900% increase in the C2 ion of [maltohexaose + Li]+. The use of a heavy collision gas in addition to the helium bath gas generally produced a signal enhancement inferior to the same experiment without the heavy gas.
authors.affiliation: Chemistry Department, University of North Carolina at Chapel Hill, 27599, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Asam
authors.forename: Gary L
authors.initials: GL
authors.lastname: Glish
mesh_terms: D000465:Algorithms; D001128:Argon; D006371:Helium; D013058:Mass Spectrometry; D011134:Polysaccharides / Q000737:chemistry*
chemical_list: D011134:Polysaccharides; D006371:Helium; D001128:Argon