title: Endometrial cell specific gene activation during implantation and early pregnancy.
abstract: Human endometrium expresses numerous genes to achieve an optimal uterine environment for implantation and maintaining the pregnancy. In this review, we will summarize our previous observations on progestin regulated gene expression, estrogen metabolic enzymes, nitric oxide synthase, aromatase, IGF-I and II, IGFBP-1, prolactin and glycodelin. These genes are differentially activated in two types of endometrial cells during the menstrual cycle and early pregnancy. Multiple gene activation driven by progestin appears to be the major event responsible for the differentiation of endometrial cells. They play critical roles of endometrial cell function during implantation and pregnancy.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794, USA. litseng@notes.cc.sunysb.edu
authors.forename: Linda
authors.initials: L
authors.lastname: Tseng
authors.forename: James
authors.initials: J
authors.lastname: Mazella
mesh_terms: D010064:Embryo Implantation / Q000235:genetics*; D004717:Endometrium / Q000737:chemistry / Q000166:cytology* / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000235:genetics*; D015533:Transcriptional Activation