title: Squamous cell carcinoma arising in a venous ulcer as a complication of the Klippel-Trenaunay syndrome.
abstract: Klippel-Trenaunay (KT) syndrome is a vascular malformation characterized by a port-wine stain, varicose veins and hypertrophy of the affected limb. Ulceration is considered an uncommon complication of KT syndrome and occurrence of skin cancer has been previously reported only in one case. We observed a case of KT syndrome in a 48-year-old woman who developed a large ulcer and a squamous cell carcinoma on the affected leg.
authors.affiliation: Department of Dermatology, Catholic University of the Sacred Heart, Rome, Italy. lutri@tin.it
authors.forename: C
authors.initials: C
authors.lastname: De Simone
authors.forename: A R
authors.initials: AR
authors.lastname: Giampetruzzi
authors.forename: C
authors.initials: C
authors.lastname: Guerriero
authors.forename: M
authors.initials: M
authors.lastname: De Masi
authors.forename: P
authors.initials: P
authors.lastname: Amerio
authors.forename: G
authors.initials: G
authors.lastname: Cina
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D005260:Female; D006801:Humans; D007715:Klippel-Trenaunay-Weber Syndrome / Q000150:complications*; D007866:Leg; D008875:Middle Aged; D012878:Skin Neoplasms / Q000209:etiology*; D014647:Varicose Ulcer / Q000150:complications*