title: Cobalt and chromium concentrations in patients with metal-on-metal and other cementless total hip arthroplasty.
abstract: We measured the cobalt and chromium concentrations in the serum and urine of 32 patients with current designed metal-on-metal total hip arthroplasty and 43 patients with conventional metal on ultrahigh molecular weight polyethylene (UHMWPE) cementless total hip arthroplasty. The results of our study showed that the serum and urine chromium concentrations increased in 37.5% and 90.6%, respectively, of 32 patients with well-fixed metal articulation (the mean values were 0.09 microg/dl and 2.2 microg/l, respectively) and also increased in 28.6% and 85.7%, respectively, of 7 patients who received metal-on-UHMWPE articulation with loosened acetabular component or stem made of Co/Cr alloy (the mean values were 0.06 microg/dl and 1.6 microg/l, respectively). On the other hand, the serum and urine cobalt concentrations were below the detection limit in all patients.
authors.affiliation: Department of Orthopaedics, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. maeza@med.juntendo.ac.jp
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Maezawa
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nozawa
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Hirose
authors.forename: Keiji
authors.initials: K
authors.lastname: Matsuda
authors.forename: Motoo
authors.initials: M
authors.lastname: Yasuma
authors.forename: Katsuo
authors.initials: K
authors.lastname: Shitoto
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kurosawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip; D002857:Chromium / Q000032:analysis*; D002858:Chromium Alloys; D003035:Cobalt / Q000032:analysis*; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011095:Polyethylenes; D011475:Prosthesis Failure
chemical_list: D002858:Chromium Alloys; D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene; D002857:Chromium; D003035:Cobalt