Persistent infection with human papillomavirus following the successful treatment of high grade cervical intraepithelial neoplasia.
In a need case-control study, we identified women who were successfully treated for CIN 3. Cases had biopsy proven recurrence, whilst controls remained disease free for at least five years. One hundred and seventy-two women were beta-globin positive at diagnostic and at six-month post-treatment smear (90 controls and 82 cases). Thirty-nine cases (47.6%) were HPV16/18 positive at biopsy or follow up smear and 14 (17.1%) of 82 were positive at both. Of the controls, 37 (41.1%) were HPV positive at biopsy or smear with (3.3%) positive at both. The unadjusted OR associated with being HPV positive at both points compared to being HPV negative at both was 8.0 (95% CI 2.13-30.37). The persistence of HPV 16/18 infection following the confirmed eradication of CIN is a highly significant risk factor for recurrence.
Cruickshank
Margaret E
ME
Wellbeing Centre for the Prevention of Cervical Cancer, University of Aberdeen, UK.
Sharp
Linda
L
Chambers
George
G
Smart
Louise
L
Murray
Graeme
G
D000328:Adult; D016022:Case-Control Studies; D017115:Catheter Ablation / Q000379:methods; D015331:Cohort Studies; D003972:Diathermy / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000821:virology; D016017:Odds Ratio; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications*; D012008:Recurrence; D014412:Tumor Virus Infections / Q000150:complications*; D002583:Uterine Cervical Neoplasms / Q000601:surgery / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000601:surgery / Q000821:virology*