Effect of ozagrel hydrochloride, a thromboxane synthetase inhibitor, on alcoholic beverage-induced bronchoconstriction in asthmatic patients.
Acetaldehyde is thought to be a main factor of alcohol-induced asthma. The thromboxane (TX) synthetase inhibitor, ozagrel hydrochloride, inhibits acetaldehyde-induced bronchoconstriction in asthmatic patients. The present study evaluated the involvement of TXA(2) on alcoholic beverage-induced bronchoconstriction. Four patients with alcohol-induced asthma received ozagrel (400 mg for 4 days) or placebo using a single-blind, randomized, cross-over design. On two separate study days, each subject drank the same brand and volume of alcoholic beverage (beer or Japanese sake) and bronchoconstriction was assessed as the change in peak expiratory flow (PEF). The effect of ozagrel on the aerosolized challenge of acetaldehyde was investigated in the same subjects. Although aerosolized acetaldehyde-induced bronchoconstriction was significantly prevented by ozagrel, there were no differences in the time course of the decrease in PEF or the maximum fall in PEF after alcohol intake between placebo and ozagrel. We conclude that TXA(2) is not involved in alcoholic beverage-induced bronchoconstriction.
Myou
Shigeharu
S
The Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan. myous@nifty.com
Fujimura
Masaki
M
Nishi
Kohichi
K
Kita
Toshiyuki
T
Kurashima
Kazuyoshi
K
Tachibana
Hideki
H
Ishiura
Yoshihisa
Y
Nakao
Shinji
S
D000079:Acetaldehyde / Q000494:pharmacology; D000328:Adult; D000434:Alcoholic Beverages / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000201:enzymology / Q000503:physiopathology*; D001515:Beer / Q000009:adverse effects; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000187:drug effects*; D006801:Humans; D008297:Male; D008689:Methacrylates / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D018401:Sample Size; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*; D014920:Wine / Q000009:adverse effects
D008689:Methacrylates; D013930:Thromboxane-A Synthase; D000079:Acetaldehyde; C034364:ozagrel