[The relationship between physical distance and genetic distance on chromosome 22].
OBJECTIVE
To construct a genetic map based on data from the Chinese population in northern part of China and to compare relationship between physical distance and genetic distance on chromosome 22.


METHODS
PCR amplification was employed to genotype 6 STR loci on chromosome 22, and pedigree analysis was performed.


RESULTS
A genetic map of Chinese Han population in the northern part of China was constructed and a preliminary comparison of the physical and genetic distances between 6 STR loci on chromosome 22 was made.


CONCLUSIONS
There is complex relationship between genetic distance and physical distance: the distance between STR loci is related to physical distance but also recombination fraction, and there are differences of the genetic and physical distances on chromosome 22 between Chinese and Caucasian, and between the male and female.
Tang
Jianpin
J
West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. rechtsme@wcums.edu.cn
Hou
Yiping
Y
Li
Yingbi
Y
Wu
Jin
J
Zhang
Jian
J
D002681:China; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D010375:Pedigree