Usefulness of the modified lavage technique of Bingisser and KL-6 monitoring in a patient with pulmonary alveolar proteinosis.
A 48-year-old man diagnosed as pulmonary alveolar proteinosis (PAP) received a whole-lung lavage by the conventional lavage technique, but he failed to show any clinical or functional improvement. Therefore, we applied a modified lavage technique of Bingisser resulting in the impressive clinical and functional improvement. We measured the levels of KL-6 in bronchoalveolar lavage fluid (BALF) at selected time intervals. KL-6 levels in BALF were higher during the lavage by the modified lavage technique of Bingisser than the conventional lavage technique. We were able to verify the usefulness of the modified lavage technique of Bingisser by monitoring the levels of KL-6 in BALF. The modified lavage technique of Bingisser may be useful for PAP treatment.
Ishikawa
Nobuhisa
N
Second Department of Internal Medicine, Hiroshima University Faculty of Medicine.
Kondo
Keiichi
K
Oguri
Tetsuya
T
Kamitsuna
Masakazu
M
Sakurai
Joji
J
Fujitaka
Kazunori
K
Yamasaki
Masahiro
M
Maeda
Hiroyuki
H
Isobe
Takeshi
T
Kohno
Nobuoki
N
D000941:Antigens / Q000032:analysis*; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000032:analysis; D018893:Bronchoalveolar Lavage / Q000379:methods*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins / Q000032:analysis; D011649:Pulmonary Alveolar Proteinosis / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins