title: Use of sevoflurane during cardiopulmonary bypass decreases incidence of awareness.
abstract: OBJECTIVE
  The role of sevoflurane has not been studied in relation to awareness during anaesthesia. We observed the effect of sevoflurane on the incidence of awareness during cardiopulmonary bypass for open-heart surgery.
  
  
  METHODS
  Fifty-nine patients of age >17 yr undergoing open-heart surgery with cardiopulmonary bypass were randomly assigned to two groups. In both groups, induction was with etomidate, dehydrobenzperidol and fentanyl; anaesthesia was maintained with sevoflurane, fentanyl and N20; vecuronium was used for muscular paralysis. Group 1 (30 patients) received dehydrobenzperidol and fentanyl during cardiopulmonary bypass; Group 2 (29 patients) received sevoflurane and fentanyl. Patients were given different auditory inputs during different phases of surgery. All patients were interviewed with standard questions 8 and 24 h postoperatively for evidence of explicit awareness.
  
  
  RESULTS
  Five patients in the dehydrobenzperidol group gave a history of awareness (16.67%) as opposed to none in the sevoflurane group. The difference in the incidences of awareness was significant (P < 0.05), but no differences were found between the interviews conducted at 8 and 24 h. Sevoflurane and opioid combination reduced the incidence of awareness in open-heart surgery.
authors.affiliation: Hacettepe University Medical School, Department of Anaesthesiology, Ankara, Turkey. bilgesel@superonline.com.tr
authors.forename: B
authors.initials: B
authors.lastname: Celebioğlu
authors.forename: A G
authors.initials: AG
authors.lastname: Pamuk
authors.forename: U
authors.initials: U
authors.lastname: Aypar
authors.forename: I
authors.initials: I
authors.lastname: Paşaoğlu
mesh_terms: D000328:Adult; D000368:Aged; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D001364:Awareness / Q000187:drug effects*; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D000077149:Sevoflurane
chemical_list: D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane