title: [Metabolic factors in school children population associated with adult cardiovascular mortality. Four provinces' study].
abstract: BACKGROUND
  Environmental factors in early stages of life may contribute to adult cardiovascular disease. We have examined certain anthropometric and biochemical variables in children aged 6-7 years from four Spanish provinces with high differences in mortality due to ischemic heart disease (IHD).
  
  
  METHODS
  We performed a cross-sectional survey of 1,255 children (50.3% males) attending schools in Cádiz and Murcia provinces with a relatively high IHD mortality and Madrid and Orense provinces with a relatively low IHD mortality. Weight, body mass index (BMI) and prevalence of obesity were analyzed, and plasma glucose and lipid levels were measured by standardized methods.
  
  
  RESULTS
  Compared with children in the two low-IHD-mortality provinces, those in the two high-IHD-mortality provinces had greater weight (p < 0.05) and BMI (p < 0.01) and higher prevalence of obesity (p < 0.01). Moreover, they had significantly higher (p < 0.01) plasma glucose, triglyceride and apo A-I levels.
  
  
  CONCLUSIONS
  The higher prevalence of overweight and obesity, along with higher plasma glucose and triglyceride levels, in provinces with high coronary artery disease mortality indicates that children from these provinces are metabolically different from those in provinces with low coronary artery disease mortality. These alterations may thus contribute to the different IHD mortality in adulthood.
authors.affiliation: Unidad de Lípidos, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Garcés
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Lasunción
authors.forename: Henar
authors.initials: H
authors.lastname: Ortega
authors.forename: Luis
authors.initials: L
authors.lastname: López Cubero
authors.forename: Mercedes
authors.initials: M
authors.lastname: Benavente
authors.forename: Rafael
authors.initials: R
authors.lastname: Rubio
authors.forename: José L
authors.initials: JL
authors.lastname: Del Barrio
authors.forename: Fernando
authors.initials: F
authors.lastname: Rodríguez Artalejo
authors.forename: Diego
authors.initials: D
authors.lastname: Gómez Coronado
authors.forename: Manuel de
authors.initials: Md
authors.lastname: Oya
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000401:mortality*; D002648:Child; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000150:complications*; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D001786:Blood Glucose; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol
vernacular_title: Factores metabólicos en la población escolar asociados a mortalidad cardiovascular en los adultos. Estudio Cuatro Provincias.