title: Formulation approaches for orally administered poorly soluble drugs.
abstract: Despite having pharmacodynamic or target activity, many drugs fail in the drug development process due to poor bioavailability, and presently marketed conventional dosage forms of poorly soluble drugs employ high doses leading to potential toxicity. The introduction of the Biopharmaceutic Classification System (BCS) has provided a basis to categorize drugs based on the two major parameters affecting absorption, solubility and permeability. Several techniques can be employed to enhance the absorption and bioavailability of poorly soluble and poorly permeable drugs based on the BCS concept. This article is an attempt to summarize the development of various formulation approaches that are currently employed to enhance bioavailability of orally administered poorly soluble drugs.
authors.affiliation: Department of Pharmaceutical Sciences, Idaho State University, Pocatello, Idaho, USA.
authors.forename: S
authors.initials: S
authors.lastname: Pinnamaneni
authors.forename: N G
authors.initials: NG
authors.lastname: Das
authors.forename: S K
authors.initials: SK
authors.lastname: Das
mesh_terms: D001702:Biopharmaceutics; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D005079:Excipients; D010539:Permeability; D012995:Solubility
chemical_list: D005079:Excipients