Lembehsterols A and B, novel sulfated sterols inhibiting thymidine phosphorylase, from the marine sponge Petrosia strongylata.
Lembehsterols A (1) and B (2), two novel sulfated sterols, were isolated from the marine sponge Petrosia strongylata. Both sterols showed inhibitory activity against thymidine phosphorylase, which is an enzyme related to angiogenesis in solid tumors. The structures of these sulfated sterols were established on the basis of chemical and physicochemical evidence.
Aoki
Shunji
S
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Naka
Yoshiharu
Y
Itoh
Takuya
T
Furukawa
Tatsuhiko
T
Rachmat
Rachmaniar
R
Akiyama
Shin-ichi
S
Kobayashi
Motomasa
M
D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008386:Marine Biology; D011161:Porifera / Q000201:enzymology*; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013939:Thymidine Phosphorylase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D004791:Enzyme Inhibitors; D013261:Sterols; C464722:lembehsterol A; C464723:lembehsterol B; D013939:Thymidine Phosphorylase