title: Positive effects of a chicken eggshell powder-enriched vitamin-mineral supplement on femoral neck bone mineral density in healthy late post-menopausal Dutch women.
abstract: Although bone metabolism is largely under genetic control, the role of nutrition is considerable. The present study evaluates the effects of chicken eggshell powder, a new source of dietary Ca, and purified CaCO3 on bone mineral density (BMD) of the lumbar spine and hip. Besides BMD we also looked at biochemical markers of bone and Ca metabolism. Both Ca sources were provided in combination with minerals and vitamins including Mg, cholecalciferol and phylloquinone. We designed a randomised, double-blind, placebo-controlled study to take place over 12 months. Healthy Caucasian women (n 85), selected by age (> or =50 and <70 years), from the databases of general practitioners were recruited by telephone calls. They had to be at least 5 years post-menopausal, with lumbar spine T-score being > - 2.5. At baseline, their mean habitual daily Ca intake was adequate. The women were randomly allocated to: eggshell powder-enriched (group A; n 24), purified CaCO3-enriched (group B; n 22), or a placebo product (group C; n 27). BMD was measured at baseline and then after 6 and 12 months of supplementation as were the biochemical markers bone-specific alkaline phosphatase, amino-terminal propeptide extension of type I collagen, deoxypyridinoline, calcitonin, intact parathyroid hormone, calcidiol, and urinary Ca. After 12 months of supplementation, only mean BMD of the femoral neck in group A was significantly increased (P=0.014) by 1.75% (95% CI 0.18, 3.32) compared with a decrease of -0.60% (95% CI -1.92, 0.72) in group C. This increase coincided with significant decreases in markers of bone resorption and formation. No significant changes were seen in BMD at other sites, including lumbar spine, nor in groups B and C. No differences were found between groups A and B, or B and C. The present study indicates that healthy late post-menopausal women with an adequate Ca intake at baseline may increase BMD of the hip within 12 months following supplementation with the chicken eggshell powder-enriched supplement.
authors.affiliation: Department of Research & Development Leeuwarden, Friesland Coberco Dairy Foods, The Netherlands. a.schaafsma@FDF.nl
authors.forename: Anne
authors.initials: A
authors.lastname: Schaafsma
authors.forename: Jasper J
authors.initials: JJ
authors.lastname: van Doormaal
authors.forename: Frits A J
authors.initials: FA
authors.lastname: Muskiet
authors.forename: Gert J H
authors.initials: GJ
authors.lastname: Hofstede
authors.forename: Igor
authors.initials: I
authors.lastname: Pakan
authors.forename: Eveline
authors.initials: E
authors.lastname: van der Veer
mesh_terms: D000367:Age Factors; D000368:Aged; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000008:administration & dosage / Q000627:therapeutic use; D002119:Calcium Carbonate / Q000627:therapeutic use; D002645:Chickens; D019587:Dietary Supplements; D004311:Double-Blind Method; D004338:Drug Combinations; D004528:Egg Shell / Q000737:chemistry*; D005260:Female; D005272:Femur Neck / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control*; D010349:Patient Compliance; D017698:Postmenopause / Q000502:physiology; D014131:Trace Elements / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D004338:Drug Combinations; D014131:Trace Elements; D014815:Vitamins; D002119:Calcium Carbonate; D002118:Calcium