title: Bleeding after loop electrosurgical excision procedure performed in either the follicular or luteal phase of the menstrual cycle: a randomized trial.
abstract: OBJECTIVE
  To estimate the perioperative or postoperative bleeding rates after treatment of cervical intraepithelial neoplasia by loop electrosurgical excision procedure in either the follicular or luteal phase of the menstrual cycle.
  
  
  METHODS
  A randomized controlled trial was carried out to compare the outcomes in terms of primary and secondary hemorrhage between patients treated by loop electrosurgical excision procedure during either the follicular (30 women) or luteal phase (30 women) of the menstrual cycle. The two groups did not differ in terms of mean age, grade of cervical intraepithelial neoplasia, depth of excision, parity, and duration of menses. Primary outcome measures included the objective and subjective assessment of intraoperative and postoperative bleeding.
  
  
  RESULTS
  Women treated during the luteal phase of the menstrual cycle experienced significantly more postoperative bleeding than women treated during the follicular phase, as assessed by the fall in hematocrit levels (P <.001) and subjective reports. Intraoperative bleeding was judged to be more severe in women treated during the luteal phase of the cycle by a single, blinded colposcopist (P =.02). These women also experienced higher levels of anxiety postoperatively, which resulted in more consultations with medical staff (P =.007).
  
  
  CONCLUSIONS
  The use of loop electrosurgical excision procedure to treat cervical intraepithelial neoplasia results in less bleeding if performed during the follicular phase of the menstrual cycle.
authors.affiliation: Department of Obstetrics and Gynecology, Ioannina University Hospital, Ioannina, Greece. vangelispar@hotmail.com
authors.forename: Evangelos
authors.initials: E
authors.lastname: Paraskevaidis
authors.forename: Emma J
authors.initials: EJ
authors.lastname: Davidson
authors.forename: George
authors.initials: G
authors.lastname: Koliopoulos
authors.forename: Yannis
authors.initials: Y
authors.lastname: Alamanos
authors.forename: Evangelos
authors.initials: E
authors.lastname: Lolis
authors.forename: Pierre
authors.initials: P
authors.lastname: Martin-Hirsch
mesh_terms: D000328:Adult; D016063:Blood Loss, Surgical; D004598:Electrosurgery / Q000009:adverse effects*; D005260:Female; D005498:Follicular Phase; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D008183:Luteal Phase; D008597:Menstrual Cycle; D019106:Postoperative Hemorrhage / Q000209:etiology; D011446:Prospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000601:surgery*; D014592:Uterine Hemorrhage / Q000209:etiology; D002578:Uterine Cervical Dysplasia / Q000601:surgery*