title: Clinical effects of betamethasone and hyaluronan, and of defocalized carbon dioxide laser treatment on traumatic arthritis in the fetlock joints of horses.
abstract: The clinical effects of intra-articular betamethasone together with hyaluronan (betaM/HA) and treatment with a defocalized carbon dioxide laser on acute traumatic arthritis of the fetlock joint were assessed. The horses in these studies were selected using a thorough lameness examination, including intra-articular anaesthesia abolishing the lameness. This investigation comprised an observer-blind study, including 10 sport horses (10 joints), and a prospective study, including 180 sport horses (333 joints). In both studies, the material was divided into two groups treated with either betaM/HA or a carbon dioxide laser. The treatment doses were 12 mg of betaM, 20 mg of HA or 60 J/cm2 of treated area. Convalescence before training was 21 days for both groups in the observer-blind study. In the prospective study, convalescence in the betaM/HA group was 21 days but was only 7 days for the laser-treated group. In the observer-blind study, three of five treated joints recovered in both cohorts. In the prospective study, the groups had significantly different recovery rates--68% of the betaM/HA-treated joints and 80% of the carbon dioxide laser-treated joints. These results indicate that the defocalized carbon dioxide laser should be an applicable mode of treatment of acute traumatic synovitis in horses. However, the biochemical functions related to carbon dioxide laser treatment require further elucidation.
authors.affiliation: Mälaren Equine Clinic, Sigtuna, Sweden.
authors.forename: A C
authors.initials: AC
authors.lastname: Lindholm
authors.forename: U
authors.initials: U
authors.lastname: Swensson
authors.forename: N
authors.initials: N
authors.lastname: de Mitri
authors.forename: E
authors.initials: E
authors.lastname: Collinder
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001168:Arthritis / Q000601:surgery / Q000628:therapy / Q000662:veterinary*; D001623:Betamethasone / Q000008:administration & dosage*; D002245:Carbon Dioxide; D005260:Female; D006734:Horse Diseases / Q000601:surgery / Q000628:therapy*; D006736:Horses / Q000293:injuries; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007270:Injections, Intra-Articular / Q000662:veterinary; D007794:Lameness, Animal / Q000209:etiology / Q000628:therapy; D053685:Laser Therapy / Q000379:methods / Q000662:veterinary*; D008297:Male; D011446:Prospective Studies; D016037:Single-Blind Method
chemical_list: D000276:Adjuvants, Immunologic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002245:Carbon Dioxide; D006820:Hyaluronic Acid; D001623:Betamethasone