Temporary ventricular drainage and emergency radiotherapy in the management of hydrocephalus associated with germinoma.
OBJECTIVE
The authors used an alternative strategy to avoid shunt placement for hydrocephalus associated with germinoma, and the ensuing complications.


METHODS
Between 1998 and 2000, five patients presenting with germinomas of the pineal area and symptomatic obstructive hydrocephalus were treated with a novel strategy. On arrival, they underwent ventriculostomy placement and one of several surgical procedures to obtain tissue for diagnosis. Within several days of the initial diagnosis, stereotactically guided fractionated radiotherapy was started. All patients experienced rapid tumor shrinkage and resolution of hydrocephalus, allowing discontinuation of external ventricular drainage without the need for permanent shunting of cerebrospinal fluid. To date, follow up reveals 100% radiographically and clinically confirmed tumor control.


CONCLUSIONS
Prompt resolution of hydrocephalus and absence of complications make this a potentially valuable therapy for control of germinomas and their symptoms.
Buatti
John M
JM
Department of Radiation Oncology, University of Iowa, Iowa City, USA.
Friedman
William A
WA
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery*; D002552:Cerebral Ventricles / Q000528:radiation effects* / Q000601:surgery*; D002648:Child; D019583:Dose Fractionation, Radiation; D004322:Drainage; D004638:Emergency Treatment; D005260:Female; D005500:Follow-Up Studies; D018237:Germinoma / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology* / Q000532:radiotherapy / Q000601:surgery*; D008297:Male; D017063:Outcome Assessment, Health Care; D013997:Time Factors; D014696:Ventriculostomy