title: [The open lung concept. Clinical application in severe thoracic trauma].
abstract: BACKGROUND
  The pathomorphological substratum of the pulmonary contusion is a parenchymatous hemorrhage followed by interstitial and alveolar edema, finally resulting in a severe damage of the surfactant system. The pathophysiological consequence is an imbalance between ventilation and perfusion, which causes the clinical finding of hypoxia.
  
  
  METHODS
  Between December 1997 and December 2000, we treated 32 polytraumatized patients (ISS 43, PTS 32) additionally suffering from severe chest contusion (AIS 5, PTST 14), by ventilation according to the Open Lung Concept (OLC). The initial disturbance of oxygenation was shown by a mean paO2/FIO2-ratio of 134 (96;181) mmHg. The OLC recruits atelectatic lung areas by the application of a defined temporary positive inspiratory pressure (PIP), which is called the "opening pressure". The recruited lung areas were kept open by high total-PEEP.
  
  
  RESULTS
  For the recruitment procedure, a mean PIP of 65 (51;65) mbar was required. Recruited alveoli were kept open by a total-PEEP of 22 (20;23) mbar. The paO2/FIO2-ratio increased significantly (P < 0.001) from 134 (96;181) to 522 (433;587) mmHg. After the recruitment procedure, we could reduce PIP and FIO2. In spite of the minimal tidal volumes of 3.5 (3.0;3.9) ml per kg bodyweight by which our patients were ventilated, the levels of oxygenation and normocapnia could be maintained. There were no evidences for side-effects like perfusion impairment. Two patients (6.25%) died of extrapulmonary causes.
  
  
  CONCLUSIONS
  Ventilation according to the OLC seems to be a highly effective treatment of ventilation-perfusion-impairment following pulmonary contusion. Minimal tidal volumes and the low PIP-levels after the recruitment procedure meet the demands of a lung-protective Low-Tidalvolume-Ventilation.
authors.affiliation: Chirurgische ITS, Zentrum für Chirurgie, Universität Leipzig, Liebigstrasse 20a, 04103 Leipzig. dschr@medizin.uni-leipzig.de
authors.forename: D
authors.initials: D
authors.lastname: Schreiter
authors.forename: A
authors.initials: A
authors.lastname: Reske
authors.forename: L
authors.initials: L
authors.lastname: Scheibner
authors.forename: C
authors.initials: C
authors.lastname: Glien
authors.forename: S
authors.initials: S
authors.lastname: Katscher
authors.forename: C
authors.initials: C
authors.lastname: Josten
mesh_terms: D000293:Adolescent; D000328:Adult; D003288:Contusions / Q000503:physiopathology / Q000628:therapy*; D003422:Critical Care; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology; D055370:Lung Injury; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000503:physiopathology / Q000628:therapy*; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration; D011446:Prospective Studies; D001261:Pulmonary Atelectasis / Q000503:physiopathology / Q000628:therapy*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D013898:Thoracic Injuries / Q000503:physiopathology / Q000628:therapy*; D014692:Ventilation-Perfusion Ratio / Q000502:physiology
chemical_list: D010100:Oxygen
vernacular_title: Das Open Lung Concept. Klinische Anwendung beim schweren Thoraxtrauma.