Pb and Cd poisoning during development alters cerebellar and striatal function in rats.
The present study was designed to examine more fully the neurochemical and behavioral interactions that derive from continued lead and cadmium poisoning in pups, whose mothers were exposed via drinking water (300 mg/l of Pb and 10 mg/l of Cd) throughout pregnancy and lactation. At weaning, these metals produced an increase in DOPAC, 5-HT and 5-HIAA contents in cerebellum, but the monoamine contents in striatum remained unaltered. The cerebral energetic metabolism was modified by the Cd-Pb exposition only in striatum. On the other hand, the Na+/K+-ATPase activity was inhibited significantly in both regions at PN21, whereas the alkaline phosphatase activity was not affected by the treatment. The intoxicated animals showed a short-term normocitic anemia, but revealed long-term alterations in the motor activity in open-field, where they showed an increase in both ambulating and rearing. So, it can be concluded that perinatal exposure to lead and cadmium provoke neurochemical alterations in cerebellum and striatum that can be related with the changes in motor activity observed in the adulthood.
Antonio
M Teresa
MT
Department of Animal Biology II, Faculty of Biology, Complutense University, 20840, Madrid, Spain.
López
Noelia
N
Leret
M Luisa
ML
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000014:Abnormalities, Drug-Induced; D000818:Animals; D000831:Animals, Newborn; D002104:Cadmium / Q000008:administration & dosage / Q000633:toxicity*; D002531:Cerebellum / Q000187:drug effects* / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004326:Drinking; D004338:Drug Combinations; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007774:Lactation; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism; D013723:Teratogens / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects
D004338:Drug Combinations; D013723:Teratogens; D002104:Cadmium; D015102:3,4-Dihydroxyphenylacetic Acid; D007854:Lead; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D000254:Sodium-Potassium-Exchanging ATPase