Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: clinical manifestation and dosimetric description.
Twelve patients with hepatocellular carcinoma and chronic hepatitis developed radiation-induced liver disease (RILD) after three-dimensional conformal radiotherapy. Six patients died of RILD and six recovered. Mean prescribed dose was 50.6+/-4.3Gy, in a daily fraction of 1.8-2.0Gy. Commonly used dosimetric parameters, such as fraction volume of normal liver with radiation dose >30Gy, prediction score, and normal tissue complication probability, failed to differentiate the fatality and clinical types of this complication. Elevated transaminases are more frequently seen than ascites and elevated alkaline phosphamide are seen in patients with RILD.
Cheng
Jason Chia-Hsien
JC
Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, No. 125 Lih-Der Road, Pei-Tou, Taipei, Taiwan, ROC.
Wu
Jian Kuen
JK
Huang
Chao Ming
CM
Huang
David Y
DY
Cheng
Skye H
SH
Lin
Yu Mong
YM
Jian
James J
JJ
Yang
Po Sheng
PS
Chuang
Vincent P
VP
Huang
Andrew T
AT
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000532:radiotherapy*; D003937:Diagnosis, Differential; D005260:Female; D006521:Hepatitis, Chronic / Q000150:complications; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis* / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000175:diagnosis* / Q000209:etiology*; D011874:Radiometry; D020266:Radiotherapy, Conformal / Q000009:adverse effects*