Microbial evolution: antitoxin vaccines and pathogen virulence.
In their mathematical description of vaccine-induced immunity, Gandon et al. predict that the host's immunity to a microbial toxin will lead to increased virulence of the pathogen without affecting its transmission. However, results obtained using vaccines against two additional bacterial pathogens are not consistent with this prediction. The model proposed by Gandon et al. may therefore be an oversimplification, with the outcome depending on the biological details of both the pathogen and the vaccine.
Soubeyrand
Benoit
B
Department of Medical Affairs, Aventis Pasteur, 69007 Lyon, France.
Plotkin
Stanley A
SA
D000222:Adaptation, Physiological; D000293:Adolescent; D000992:Antitoxins / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D005075:Biological Evolution; D002648:Child; D002675:Child, Preschool; D003353:Corynebacterium diphtheriae / Q000276:immunology* / Q000472:pathogenicity* / Q000502:physiology; D004165:Diphtheria / Q000453:epidemiology / Q000276:immunology / Q000635:transmission; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology; D006790:Host-Parasite Interactions; D006801:Humans; D007223:Infant; D018448:Models, Immunological; D012641:Selection, Genetic; D013548:Sweden / Q000453:epidemiology; D014774:Virulence
D000992:Antitoxins; D001428:Bacterial Vaccines; D015721:Diphtheria-Tetanus-Pertussis Vaccine