Stress-related diseases -- a potential role for nitric oxide.
Nitric oxide (NO) is involved in stress physiology and stress-related disease processes. Like stress, NO seems to be capable of principally exerting either beneficial or deleterious effects. The actual distinction depends on a multitude of factors. Moreover, NO counteracts norepinephrine (NE) activity and sympathetic responsivity. Thus, NO and the stress (patho)physiology are closely connected and molecular mechanisms or pathways may be shared under certain conditions. NO is involved in immunological, cardiovascular, and neurodegenerative diseases/ mental disorders. It represents a 'double-edged sword', since small quantities produced by constitutive enzymes may predominantly mediate physiological effects, whereas the expression of inducible NO synthases may lead to larger quantities of NO, a situation that may be associated with cytotoxic and detrimental effects of NO. The key step for normally useful physiological mechanisms becoming pathophysiological may be represented by the loss of balance, the loss of control over the different pathways induced. A failure to terminate or shift originally protective mechanisms may lead to a vicious cycle of disease-supporting pathophysiological pathways.


CONCLUSIONS
Profound connections between stress and various disease processes exist. Thereby, common pathophysiological pathways in stress-related diseases have been described, and they involve stress hormone (cortisol, NE) and, in particular, NO activity. Thus, NO has detrimental capacities. However, NO not only exerts deleterious but also strongly ameliorating effects. The balance between both properties is crucial. Yet, nitric oxide involvement in stress-related diseases represents a common pathway, with various pathophysiological analogies, that may be accessible for strategies using stress management and relaxation response techniques.
Esch
Tobias
T
The Mind/ Body Medical Institute, CareGroup and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. tesch@caregroup.harvard.edu
Stefano
George B
GB
Fricchione
Gregory L
GL
Benson
Herbert
H
D002318:Cardiovascular Diseases / Q000150:complications / Q000503:physiopathology; D006801:Humans; D001523:Mental Disorders / Q000150:complications / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000150:complications / Q000503:physiopathology; D009569:Nitric Oxide / Q000502:physiology*; D015398:Signal Transduction; D013312:Stress, Physiological / Q000150:complications / Q000276:immunology / Q000503:physiopathology*
D009569:Nitric Oxide