title: Synthesis and pharmacological activity of 1,4-benzodiazepine derivatives.
abstract: 2-Aminobenzamides (3a-g) were prepared starting with isatoic anhydride. These compounds reacted with chloroacetic acid to give (4a-g), which were cyclized by dicyclohexylcorbodiimide to afford (5a-g). The preliminary pharmacological screening revealed that some of the new 2H-1,4-benzodiazepin-3,5(1H,4H)-dione derivatives (5) exhibited CNS-depressant and anticonvulsant activities.
authors.affiliation: Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
authors.forename: A N
authors.initials: AN
authors.lastname: Osman
authors.forename: A A
authors.initials: AA
authors.lastname: el-Gendy
authors.forename: R H
authors.initials: RH
authors.lastname: Omar
authors.forename: L
authors.initials: L
authors.lastname: Wagdy
authors.forename: A H
authors.initials: AH
authors.lastname: Omar
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000138:chemical synthesis* / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology; D005260:Female; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D013055:Spectrophotometry, Infrared
chemical_list: D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D003292:Convulsants; D007202:Indicators and Reagents; D001569:Benzodiazepines; D010433:Pentylenetetrazole