title: Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer.
abstract: We have found that EEF1A2, the gene encoding protein elongation factor EEF1A2 (also known as eEF-1 alpha 2), is amplified in 25% of primary ovarian tumors and is highly expressed in approximately 30% of ovarian tumors and established cell lines. We have also demonstrated that EEF1A2 has oncogenic properties: it enhances focus formation, allows anchorage-independent growth and decreases the doubling time of rodent fibroblasts. In addition, EEF1A2 expression made NIH3T3 fibroblasts tumorigenic and increased the growth rate of ES-2 ovarian carcinoma cells xenografted in nude mice. Thus, EEF1A2 and the process of protein elongation are likely to be critical in the development of ovarian cancer.
authors.affiliation: Hamilton Regional Cancer Centre, Room 450, 699 Concession Street, Hamilton, Ontario, L8V 5C2, Canada.
authors.forename: Nisha
authors.initials: N
authors.lastname: Anand
authors.forename: Sabita
authors.initials: S
authors.lastname: Murthy
authors.forename: Gudrun
authors.initials: G
authors.lastname: Amann
authors.forename: Meredith
authors.initials: M
authors.lastname: Wernick
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Porter
authors.forename: I Howard
authors.initials: IH
authors.lastname: Cukier
authors.forename: Colin
authors.initials: C
authors.lastname: Collins
authors.forename: Joe W
authors.initials: JW
authors.lastname: Gray
authors.forename: Joachim
authors.initials: J
authors.lastname: Diebold
authors.forename: Doug J
authors.initials: DJ
authors.lastname: Demetrick
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Lee
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002277:Carcinoma / Q000235:genetics; D002455:Cell Division; D002460:Cell Line; D002890:Chromosomes, Human, Pair 20; D005260:Female; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D010051:Ovarian Neoplasms / Q000235:genetics*; D020648:Peptide Elongation Factor 1 / Q000235:genetics*; D011401:Promoter Regions, Genetic; D051381:Rats; D014407:Tumor Cells, Cultured
chemical_list: C503234:EEF1A2 protein, human; C503235:Eef1a2 protein, mouse; C503236:Eef1a2 protein, rat; D020648:Peptide Elongation Factor 1