Bethesda proposals for classification of lymphoid neoplasms in mice.
A consensus system for classification of mouse lymphoid neoplasms according to their histopathologic and genetic features has been an elusive target for investigators involved in understanding the pathogenesis of spontaneous cancers or modeling human hematopoietic diseases in mice. An international panel of scientists with expertise in mouse and human hematopathology joined with the hematopathology subcommittee of the Mouse Models for Human Cancers Consortium to develop criteria for definition and classification of these diseases together with a standardized nomenclature. The fundamental elements contributing to the scheme are clinical features, morphology, immunophenotype, and genetic characteristics. The resulting classification has numerous parallels to the World Health Organization classification of human lymphoid tumors while recognizing differences that may be species specific. The classification should facilitate communications about mouse models of human lymphoid diseases.
Morse
Herbert C
HC
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0760, USA. hmorse@niaid.nih.gov
Anver
Miriam R
MR
Fredrickson
Torgny N
TN
Haines
Diana C
DC
Harris
Alan W
AW
Harris
Nancy L
NL
Jaffe
Elaine S
ES
Kogan
Scott C
SC
MacLennan
Ian C M
IC
Pattengale
Paul K
PK
Ward
Jerrold M
JM
D000818:Animals; D006801:Humans; D007938:Leukemia / Q000145:classification* / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008223:Lymphoma / Q000145:classification* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000145:classification / Q000473:pathology; D051379:Mice; D016183:Murine Acquired Immunodeficiency Syndrome / Q000473:pathology; D009316:National Institutes of Health (U.S.); D014481:United States