Growth problems in children with asthma.
Growth problems are often seen in children with asthma. Rarely, these problems may be caused by poor asthma control. Negatively-deviating growth curves in asthmatic boys aged 8-15 years are often associated with a chronic delay in growth and puberty. Daily treatment with any dose of systemic corticosteroids suppresses the growth rate for as long as the treatment is maintained. The risk of growth rate suppression due to inhaled corticosteroids depends on the dose, administration regimen and delivery device. The risk becomes significant with > or =800 microg budesonide from a metered-dose inhaler with a spacer, and with > or =400 microg budesonide or fluticasone propionate from a dry-powder inhaler. Regardless of the treatment modality applied, all children with asthma should have their height growth measured at least every 6 months, and indications for endocrine work-up should follow general criteria for a growth-insufficient child.
Wolthers
Ole D
OD
Children's Clinic Randers, Randers, Denmark. o.d.wolthers@dadlnet.dk
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D001249:Asthma / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D001827:Body Height / Q000187:drug effects; D002648:Child; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000139:chemically induced / Q000209:etiology*; D006801:Humans; D008297:Male; D010349:Patient Compliance; D011628:Puberty, Delayed / Q000209:etiology; D012189:Retrospective Studies
D000305:Adrenal Cortex Hormones