title: Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: effects on in vitro cell growth of human tumor cell lines.
abstract: In this study we compared the in vitro antiproliferative activity of extracts from medicinal plants toward human tumor cell lines, including human erythromyeloid K562, B-lymphoid Raji, T-lymphoid Jurkat, erythroleukemic HEL cell lines. Extracts from Emblica officinalis were the most active in inhibiting in vitro cell proliferation, after comparison to those from Terminalia arjuna, Aphanamixis polystachya, Oroxylum indicum, Cuscuta reflexa, Aegle marmelos, Saraca asoka, Rumex maritimus, Lagerstroemia speciosa, Red Sandalwood. Emblica officinalis extracts have been studied previously, due to their hepatoprotective, antioxidant, antifungal, antimicrobial and anti-inflammatory medicinal activities. Gas chromatography/mass spectrometry analyses allowed to identify pyrogallol as the common compound present both in unfractionated and n-butanol fraction of Emblica officinalis extracts. Antiproliferative effects of pyrogallol were therefore determined on human tumor cell lines thus identifying pyrogallol as an active component of Emblica officinalis extracts.
authors.affiliation: Pharmacology Research Laboratory, Faculty of Pharmaceutical Sciences, University Science and Technology Chittagong, Bangladesh.
authors.forename: Mahmud Tareq Hassan
authors.initials: MT
authors.lastname: Khan
authors.forename: Ilaria
authors.initials: I
authors.lastname: Lampronti
authors.forename: Dino
authors.initials: D
authors.lastname: Martello
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Bianchi
authors.forename: Shaila
authors.initials: S
authors.lastname: Jabbar
authors.forename: Mohammad Shahabuddin Kabir
authors.initials: MS
authors.lastname: Choudhuri
authors.forename: Bidduyt Kanti
authors.initials: BK
authors.lastname: Datta
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
mesh_terms: D020001:1-Butanol / Q000737:chemistry; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D002849:Chromatography, Gas; D006801:Humans; D066298:In Vitro Techniques; D009369:Neoplasms / Q000188:drug therapy*; D029842:Phyllanthus emblica / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011748:Pyrogallol / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D011748:Pyrogallol; D020001:1-Butanol