title: Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system.
abstract: T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.
authors.affiliation: The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup Hospital, 2600 Glostrup, Denmark. torbenls@dadlnet.dk
authors.forename: Torben L
authors.initials: TL
authors.lastname: Sørensen
authors.forename: Corinna
authors.initials: C
authors.lastname: Trebst
authors.forename: Pia
authors.initials: P
authors.lastname: Kivisäkk
authors.forename: Karen L
authors.initials: KL
authors.lastname: Klaege
authors.forename: Amit
authors.initials: A
authors.lastname: Majmudar
authors.forename: Rivka
authors.initials: R
authors.lastname: Ravid
authors.forename: Hans
authors.initials: H
authors.lastname: Lassmann
authors.forename: David B
authors.initials: DB
authors.lastname: Olsen
authors.forename: Robert M
authors.initials: RM
authors.lastname: Strieter
authors.forename: Richard M
authors.initials: RM
authors.lastname: Ransohoff
authors.forename: Finn
authors.initials: F
authors.lastname: Sellebjerg
mesh_terms: D000328:Adult; D000368:Aged; D001253:Astrocytes / Q000737:chemistry / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry / Q000276:immunology; D002490:Central Nervous System / Q000737:chemistry* / Q000276:immunology* / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000166:cytology; D054357:Chemokine CXCL10; D019743:Chemokines, CXC / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology* / Q000473:pathology; D009188:Myelitis, Transverse / Q000276:immunology / Q000473:pathology; D009902:Optic Neuritis / Q000276:immunology / Q000473:pathology; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000032:analysis*
chemical_list: C515187:CXCR3 protein, human; D054357:Chemokine CXCL10; D019743:Chemokines, CXC; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine