title: Bioflavonoid-rich botanical extracts show antioxidant and gene regulatory activity.
abstract: Reactive oxygen and nitrogen metabolites are obligatory and essential products of metabolism. Unregulated increase in their production is associated with a number of chronic illnesses. Diets rich in fruits, vegetables, and wines are implicated in the prevention of chronic diseases. Molecular mechanisms by which fruits and vegetables confer their disease-preventive actions are poorly defined. However, recent developments in the fields of genomics and bioinformatics provide powerful tools to investigate the mechanisms by which botanicals affect cellular functions. This monograph illustrates the potential of large-scale messenger RNA analysis to unravel the role of transcription in mediating the effects of botanical extracts with antioxidant properties. The application of microarrays and oligonucleotide arrays shows multiple effects of antioxidant extracts on the expression of a broad spectrum of genes.
authors.affiliation: Department of Internal Medicine, University of California, Davis, Davis, California 95616, USA. kgohil@ucdavis.edu
authors.forename: Kishorchandra
authors.initials: K
authors.lastname: Gohil
authors.forename: Lester
authors.initials: L
authors.lastname: Packer
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D016207:Cytokines / Q000235:genetics; D005419:Flavonoids / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects*; D020441:Ginkgo biloba; D006801:Humans; D009504:Neutrophils / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects; D000096983:Ginkgo Extract
chemical_list: D000975:Antioxidants; D016207:Cytokines; D005419:Flavonoids; D010936:Plant Extracts; D019253:Proto-Oncogene Proteins c-bcl-2; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract