title: Enhancement of IgE production in B cells by neutrophils via galectin-3 in IgE-associated atopic eczema/dermatitis syndrome.
abstract: Spontaneous IgE production by B cells from patients with IgE-associated atopic eczema/dermatitis syndrome (AEDS) is enhanced by polymorphonuclear leukocytes (PMN) from patients with AEDS, but not by PMN from non-atopic controls. The enhancement is abolished by preincubation of PMN with lactose, but not with glucose. Anti-galectin-3 serum, but not control rabbit serum, blocked the enhancement. These results indicate that AEDS PMN can enhance IgE production via galectin-3.
authors.affiliation: Department of Allergy, Unitika Central Hospital, Uji-City, Japan. unitikah@12.alpha-net.ne.jp
authors.forename: Hajime
authors.initials: H
authors.lastname: Kimata
mesh_terms: D000328:Adult; D000943:Antigens, Differentiation / Q000276:immunology*; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D002450:Cell Communication / Q000276:immunology; D003876:Dermatitis, Atopic / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D005260:Female; D037502:Galectin 3; D005947:Glucose / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology; D007785:Lactose / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology / Q000276:immunology*
chemical_list: D000943:Antigens, Differentiation; D037502:Galectin 3; D007073:Immunoglobulin E; D005947:Glucose; D007785:Lactose