Platelet antiaggregatory effects and haemodynamic activity of two terfuroxan isomer pairs.
A couple of terfuroxan isomer pairs 1a,b and 2a,b were studied for their in vivo vasodilating activity and in vitro antiplatelet action. The haemodynamic profiles of the products resemble that of other NO-donors. Their in vitro antiaggregating activity is influenced both by terfuroxan system and by the substituents.
Cena
Clara
C
Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Turin, Italy.
Visentin
Sonja
S
Gasco
Annalisa
A
Martorana
Piero Antonio
PA
Fruttero
Roberta
R
Gasco
Alberto
A
D000818:Animals; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007536:Isomerism; D008297:Male; D020030:Nitric Oxide Donors / Q000737:chemistry / Q000494:pharmacology; D010069:Oxadiazoles / Q000737:chemistry* / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D013552:Swine; D013997:Time Factors
D020030:Nitric Oxide Donors; D010069:Oxadiazoles; D010975:Platelet Aggregation Inhibitors; C010166:furoxans