Penicillin-resistant pneumococci-implications for management of community-acquired pneumonia and meningitis.
Penicillin-nonsusceptible Streptococcus pneumoniae isolates have become increasingly prevalent worldwide. They are well-known agents of community-acquired infections such as otitis media, pneumonia and bacterial meningitis. Therapy of pneumococcal infections is made difficult by the emergence and spread of bacterial resistance to penicillin and other beta-lactams, as well as other antimicrobials such as macrolides. This article reviews current concepts of epidemiology and the implications of penicillin-nonsusceptible pneumococci for management of community-acquired pneumonia and meningitis.
Ziglam
Hisham M
HM
Nottingham City Hospital, Nottingham, UK.
Finch
Roger G
RG
D017714:Community-Acquired Infections / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000382:microbiology*; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy* / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects
D010406:Penicillins