title: Calcium signaling through protein kinases. The Arabidopsis calcium-dependent protein kinase gene family.
abstract: In plants, numerous Ca(2+)-stimulated protein kinase activities occur through calcium-dependent protein kinases (CDPKs). These novel calcium sensors are likely to be crucial mediators of responses to diverse endogenous and environmental cues. However, the precise biological function(s) of most CDPKs remains elusive. The Arabidopsis genome is predicted to encode 34 different CDPKs. In this Update, we analyze the Arabidopsis CDPK gene family and review the expression, regulation, and possible functions of plant CDPKs. By combining emerging cellular and genomic technologies with genetic and biochemical approaches, the characterization of Arabidopsis CDPKs provides a valuable opportunity to understand the plant calcium-signaling network.
authors.affiliation: Department of Genetics, Harvard Medical School, MA 02114, USA.
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Cheng
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Willmann
authors.forename: Huei-Chi
authors.initials: HC
authors.lastname: Chen
authors.forename: Jen
authors.initials: J
authors.lastname: Sheen
mesh_terms: D048948:14-3-3 Proteins; D017360:Arabidopsis / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D029681:Arabidopsis Proteins; D020013:Calcium Signaling / Q000235:genetics / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D002244:Carbon / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D018506:Gene Expression Regulation, Plant / Q000187:drug effects; D007113:Immunity, Innate; D005810:Multigene Family; D009154:Mutation; D009584:Nitrogen / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D010766:Phosphorylation; D010802:Phylogeny; D010935:Plant Diseases / Q000209:etiology; D010937:Plant Growth Regulators / Q000494:pharmacology; D010940:Plant Proteins; D018514:Plant Structures / Q000254:growth & development / Q000502:physiology; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D013379:Substrate Specificity; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D017871:Calcium-Calmodulin-Dependent Protein Kinases
chemical_list: D048948:14-3-3 Proteins; D029681:Arabidopsis Proteins; D002135:Calcium-Binding Proteins; D002244:Carbon; D009584:Nitrogen; D010743:Phospholipids; D010937:Plant Growth Regulators; D010940:Plant Proteins; D011494:Protein Kinases; D014446:Tyrosine 3-Monooxygenase; C490306:ATCDPK1 protein, Arabidopsis; D017871:Calcium-Calmodulin-Dependent Protein Kinases; C490307:ATCDPK2 protein, Arabidopsis