In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model.
The in vivo activities of posaconazole, itraconazole, and amphotericin B in neutropenic mice with zygomycosis were compared. The in vitro MICs of posaconazole and itraconazole for the strains of Mucor spp. used in this study ranged from 0.125 to 8 microg/ml and 0.25 to 8 microg/ml, respectively. The in vitro MIC range for amphotericin B is 0.125 to 0.25 microg/ml. At twice-daily doses of >or=15 mg/kg of body weight, posaconazole prolonged the survival of the mice and reduced tissue burden.
Sun
Qiu N
QN
Division of Infectious Disease, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA.
Najvar
Laura K
LK
Bocanegra
Rosie
R
Loebenberg
David
D
Graybill
John R
JR
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D016867:Immunocompromised Host; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D009089:Mucor / Q000187:drug effects; D009091:Mucormycosis / Q000188:drug therapy*; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole