Effects of cerebrovascular challenges on plasma endothelin.
Plasma endothelin elevations have been associated with cerebrovascular pathology. Mechanisms of stimulation, however, are unknown. Therefore, in healthy subjects a marked physiological cerebrovascular response was experimentally provoked by hypercapnia, hypocapnia, and alternating capneic conditions. During these challenges plasma immunoreactive-endothelin-1 (ir-ET-1) concentrations were determined using a radioimmunassay. Physiological effects were continuously recorded for pCO(2), cerebral blood flow velocity, pulse frequency, and arterial blood pressure. No alterations in plasma ET-1 levels were found upon any of the cerebrovascular stimuli. We conclude that massive cerebrovascular challenges in healthy individuals do not lead to high circulating ET-1 levels.
Jordan
Wolfgang
W
Psychiatrische Klinik, Department of Psychiatry and Psychotherapy, University of Göttingen, von Sieboldstr. 5, 37075, Göttingen, Germany. wjordan@gwdg.de
Decker
Michael
M
Kamrowski
Heike
H
Brunner
Edgar
E
Ehrenreich
Hannelore
H
Hajak
Göran
G
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000502:physiology*; D019332:Endothelin-1 / Q000097:blood*; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology; D016857:Hypocapnia / Q000503:physiopathology; D008297:Male; D010313:Partial Pressure; D011674:Pulse; D011863:Radioimmunoassay; D012016:Reference Values; D017585:Ultrasonography, Doppler, Transcranial
D019332:Endothelin-1; D002245:Carbon Dioxide