title: Antimicrobial-associated acute hepatitis.
abstract: Recently, the case history of a 44-year-old woman who experienced acute hepatitis subsequent to therapy for chronic sinusitis was reviewed. The patient sequentially was administered clarithromycin, levofloxacin, amoxicillin-clavulanate, and gatifloxacin. Her adverse events were attributed definitively to gatifloxacin, a surprising conclusion because many other possible causes of hepatitis existed in this case. Not ruled out as potential causes of the clinical and laboratory adverse events were hepatitis other than hepatitis A or B. Other antimicrobials administered were dismissed. In particular, extended treatment with amoxicillin-clavulanate has been clearly linked to hepatotoxic effects that may occur long after therapy begins. Thus, while we agree that physicians must be aware of the potential for antimicrobial hepatotoxicity, we believe that this case study is not a solidly documented case of hepatitis attributable to gatifloxacin and overlooks other possible causes of acute hepatitis of which prescribers should be aware.
authors.affiliation: Infectious Diseases, Bristol-Myers Squibb, Plainsboro, New Jersey 08536, USA. Susan.Nicholson@BMS.com
authors.forename: Susan C
authors.initials: SC
authors.lastname: Nicholson
authors.forename: C Douglas
authors.initials: CD
authors.lastname: Webb
authors.forename: Robert C
authors.initials: RC
authors.lastname: Moellering
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D024841:Fluoroquinolones; D000077734:Gatifloxacin; D006801:Humans; D008111:Liver Function Tests; D009287:Naphthyridines / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C080163:trovafloxacin; D000077734:Gatifloxacin