title: Time to AIDS from 1992 to 1999 in HIV-1-infected subjects with known date of infection.
abstract: To estimate the change in AIDS incubation time during three periods characterized by different availability of antiretroviral treatments, data from the French Hospital Database on HIV of 4702 HIV-1-positive subjects with a documented date of infection were analyzed. Times from seroconversion to AIDS were compared in three periods: period 1 from January 1992 to June 1995 (monotherapy); period 2 from July 1995 to June 1996 (dual therapy); and period 3 from July 1996 to June 1999 (triple therapy). Nonparametric survival analyses were performed to account for staggered entries in the database and during each period. From periods 1 to 3, antiretroviral treatments were initiated earlier after infection, more subjects were treated, and the nature of regimens changed (25.6% of subjects were treated with monotherapy in period 1, 34.6% were treated with dual therapy in period 2, and 53.4% were treated with triple therapy in period 3). Compared with period 1, the relative hazard (RH) of AIDS was 0.31 in period 3 (95% confidence interval [CI]: 0.24-0.39). When comparing period 3 with period 2, the RH of AIDS was 0.36 (CI: 0.29-0.45). Assuming a log normal distribution, the median time to AIDS was estimated as 8.0 years in period 1 (CI: 6.0-10.6), 9.8 years in period 2 (CI: 8.5, 11.2), and 20.0 years in period 3 (CI: 17.1-23.3). This lengthening in time to AIDS from 1992 to 1999 was particularly marked in the period after the introduction of triple therapy, including protease inhibitors.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale SC4, Faculté de Médecine, St. Antoine Université Pierre et Marie Curie, Paris, France; Epicentre, Paris, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Tassie
authors.forename: Sophie
authors.initials: S
authors.lastname: Grabar
authors.forename: Rémi
authors.initials: R
authors.lastname: Lancar
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Deloumeaux
authors.forename: Michèle
authors.initials: M
authors.lastname: Bentata
authors.forename: Dominique
authors.initials: D
authors.lastname: Costagliola
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology*; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D016001:Confidence Intervals; D018450:Disease Progression; D005260:Female; D005602:France; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D015497:HIV-1; D006782:Hospitals, Special; D006801:Humans; D008297:Male; D013997:Time Factors
chemical_list: D019380:Anti-HIV Agents