[Progressive aphasia. New data on an old phenomenon].
Progressive aphasias are distinct but infrequently recognized clinical expressions of non-Alzheimer lobar atrophy. We review and illustrate two such syndromes--semantic dementia (SD) and progressive nonfluent aphasia (PA). SD involves loss of conceptual structure due to bilateral infratemporal atrophy. PA is a phonetic-syntactic disorder resulting from left perisylvian atrophy. Early research on Pick disease--originally defined as circumscribed cerebrocortical atrophy--highlighted left temporal lobe atrophy and aphasia. For this reason (among others), Pick disease or Pick complex is still a useful and convenient label for progressive aphasias and other clinical manifestations of non-AD lobar atrophy.
Ostberg
Per
P
Geriatriska kliniken, Huddinge Universitetssjukhus, Stockholm.
Andersen
Christian
C
Wahlund
Lars-Olof
LO
D000368:Aged; D018888:Aphasia, Primary Progressive / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002560:Cerebrovascular Circulation; D003704:Dementia / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon
Progressiv afasi. Nya rön om bortglömt fenomen.