title: Acute pancreatitis and acute renal failure complicating doxylamine succinate intoxication.
abstract: Doxylamine succinate is an antihistaminic drugwith additional hypnotic, anticholinergic and local anesthetic effects first described in 1948. In Korea and many other countries, it is a common-over-the counter medication frequently involved in overdoses. Clinical symtomatology of doxylamine succinate overdose includes somnolence, coma, seizures, mydriasis, tachycardia, psychosis, and rhabdomyolysis. A serious complication may be rhabdomyolysis with subsequent impairment of renal function and acute renal failure. We report a case of acute renal failure and acute pancreatitis complicating a doxylamine succinate intoxication.
authors.affiliation: Department of Internal Medicine, Chonbuk National University Medical School, Chonju, Republic of Korea.
authors.forename: Yang Deok
authors.initials: YD
authors.lastname: Lee
authors.forename: Soo Teik
authors.initials: ST
authors.lastname: Lee
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D000328:Adult; D003937:Diagnosis, Differential; D004319:Doxylamine / Q000506:poisoning*; D062787:Drug Overdose / Q000150:complications / Q000175:diagnosis; D004638:Emergency Treatment; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning*; D008297:Male; D010195:Pancreatitis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy
chemical_list: D006993:Hypnotics and Sedatives; D004319:Doxylamine