Arginine Vasopressin(4-8) Mobilizes Intracellular Calcium in C6 Glioma Cells.
To understand the mechanism of neurotrophic action of neuropeptide ZNC(C)PR, which could affect growth of C6 cells, fluorescent dye Fluo-3 and confocal laser scanning microscope were used to assay the intracellular calcium in C6 glioma cells. It was found that ZNC(C)PR and it's analogue NLPR could mobilize intracellular calcium in a dose-dependent manner. The ZNC(C)PR antagnist, ZDC(C)PR, could inhibit the process, and the extracellular calcium did not influence it.
Dong
Ming
M
Shanghai Institute of Biochemistry, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 200031, China. duyc@sunm.shcnc.ac.cn
Xu
Kan-Yan
KY
Zhen
Xiao-Guang
XG
Du
Yu-Cang
YC