Effects of antibiotic treatment on the concentrations of interleukin-6 and interleukin-8 in cervicovaginal fluid.
OBJECTIVE
We investigated to see the effect of antibiotics on interleukin (IL)-6 and IL-8 in cervicovaginal fluid in patients with premature rupture of the membranes.


METHODS
Cervicovaginal fluid was sampled on admission and before delivery for measurement of IL-6 and IL-8 from 31 patients with less than 35 weeks of gestation. Concentrations of IL-6 and IL-8 were measured by ELISA.


RESULTS
The concentrations of IL-6 in cervicovaginal fluid in patients who were delivered because of clinical chorioamnionitis with antibiotics (n = 6) were significantly higher than in patients who were delivered because of active labor with (n = 14, p = 0.0133) and without antibiotics (n = 11, p = 0.0067). A significant change in the concentrations of IL-6 and IL-8 in cervicovaginal fluid was not observed in patients with and without antibiotics who were delivered because of active labor.


CONCLUSIONS
The concentrations of IL-6 and IL-8 in cervicovaginal fluid might be influenced by the presence of clinical chorioamnionitis, but not by antibiotic administration.
Matsuda
Yoshio
Y
Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima, Japan. ymatsuda@obgy.twmu.ac.jp
Kouno
Satoshi
S
Nakano
Hitoo
H
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001826:Body Fluids / Q000737:chemistry; D002584:Cervix Uteri / Q000378:metabolism*; D002821:Chorioamnionitis / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis*; D016209:Interleukin-8 / Q000032:analysis*; D007743:Labor, Obstetric; D011247:Pregnancy; D014621:Vagina / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D015850:Interleukin-6; D016209:Interleukin-8