The undiscovered country: chromosome territories and the organization of transcription.
The interchromosome domain (ICD) model proposes that genes are selectively positioned at the surfaces of chromosome territories to facilitate their regulation. A paper in the May 13 issue of the Journal of Cell Biology provides evidence that supports a reinterpretation of this model.
Kosak
Steven T
ST
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
Groudine
Mark
M
D002467:Cell Nucleus / Q000235:genetics; D002503:Centromere / Q000737:chemistry; D002874:Chromosome Mapping; D020223:Chromosome Painting; D002875:Chromosomes / Q000235:genetics; D022041:Euchromatin / Q000235:genetics; D005786:Gene Expression Regulation; D006570:Heterochromatin / Q000737:chemistry; D007399:Interphase; D008954:Models, Biological; D014158:Transcription, Genetic / Q000235:genetics*
D022041:Euchromatin; D006570:Heterochromatin