title: Discordant Human Immunodeficiency Virus Type 1 drug resistance mutations, including K103N, observed in cerebrospinal fluid and plasma.
abstract: Discordant resistance mutations were seen in human immunodeficiency virus type 1 (HIV-1) isolated from specimens of blood and cerebrospinal fluid (CSF) obtained from 3 of 6 patients. To our knowledge, this is the first report of HIV-1 isolated from CSF harboring the K103N mutation, which confers resistance to the nonnucleoside reverse-transcriptase inhibitors, and this finding may indicate that virus in the CSF replicates independently from virus in the blood compartment.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, The Miriam Hospital/Brown Medical School, Providence, RI, 02906, USA. ktashima@lifespan.org
authors.forename: K T
authors.initials: KT
authors.lastname: Tashima
authors.forename: T P
authors.initials: TP
authors.lastname: Flanigan
authors.forename: J
authors.initials: J
authors.lastname: Kurpewski
authors.forename: S M
authors.initials: SM
authors.lastname: Melanson
authors.forename: P R
authors.initials: PR
authors.lastname: Skolnik
mesh_terms: D019943:Amino Acid Substitution; D001216:Asparagine / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D008239:Lysine / Q000235:genetics; D008826:Microbial Sensitivity Tests; D009154:Mutation; D012367:RNA, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology
chemical_list: D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; D001216:Asparagine; D008239:Lysine