title: Human water, sodium, and calcium regulation during space flight and exercise.
abstract: When one is exposed to microgravity, fluid which is normally pooled in the lower extremities is redistributed headward and weight bearing bones begin to demineralize due to reduced mechanical stresses. The kidney, which is the primary regulator of body fluid volume and composition, responds to the fluid shift and bone demineralization by increasing the urinary output of water, sodium, and calcium. This research involves developing a mathematical description of how water and electrolytes are internally redistributed and exchanged with the environment during space flight. This model consequently involves kidney function and the associated endocrine system. The model agrees well with actual data, including that a low sodium diet can prevent bone demineralization. Therefore, assumptions made to develop the model are most likely valid. Additionally, various levels of activity are also considered in the model since exercise may help to eliminate some of the undesired effects of space flight such as muscle atrophy and bone demineralization.
authors.affiliation: Iowa State University, Department of Chemical Engineering, Ames, IA 50011, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Doty
authors.forename: R C
authors.initials: RC
authors.lastname: Seagrave
mesh_terms: D000450:Aldosterone / Q000378:metabolism; D001834:Body Water; D018488:Bone Demineralization, Pathologic / Q000209:etiology / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D018495:Fluid Shifts / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008954:Models, Biological; D009399:Nephrons / Q000502:physiology; D010281:Parathyroid Hormone / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013026:Space Flight; D014556:Urine; D014667:Vasopressins / Q000378:metabolism; D014882:Water-Electrolyte Balance; D014893:Weightlessness / Q000009:adverse effects*
chemical_list: D010281:Parathyroid Hormone; D014667:Vasopressins; D000450:Aldosterone; D012964:Sodium; D002118:Calcium