title: No linkage of the interleukin-4 receptor locus on chromosome 16p11.2-12.1 with sarcoidosis in German multiplex families.
abstract: We typed 241 members of 62 sarcoidosis families with 136 affected siblings for three single nucleotide polymorphisms of the interleukin-4 receptor alpha-chain gene (IL4R). Allele frequencies in patients were compared to those of healthy unrelated control individuals. The segregation of the three-point IL4R haplotypes completed by two flanking highly polymorphic microsatellite polymorphisms revealed no evidence for linkage of the IL4R gene locus with sarcoidosis.
authors.affiliation: Institute of Clinical Immunology and Transfusion Medicine, Justus-Liebig-University Giessen, Giessen, Germany. anette.bohnert@immunologie.med.uni-giessen.de
authors.forename: A
authors.initials: A
authors.lastname: Bohnert
authors.forename: M
authors.initials: M
authors.lastname: Schürmann
authors.forename: A
authors.initials: A
authors.lastname: Hartung
authors.forename: H
authors.initials: H
authors.lastname: Hackstein
authors.forename: J
authors.initials: J
authors.lastname: Müller-Quernheim
authors.forename: G
authors.initials: G
authors.lastname: Bein
mesh_terms: D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D008040:Genetic Linkage; D005858:Germany; D006801:Humans; D019948:Receptors, Interleukin-4 / Q000235:genetics*; D012507:Sarcoidosis / Q000235:genetics*
chemical_list: D019948:Receptors, Interleukin-4