[Prevention of postoperative scars in otorhinolaryngology: experimental rationale].
It is demonstrated that in vitro inhibition of fibroblasts proliferation is feasible with the use of 5-fluorouracil. In stimulated growth of fibroblasts, the antiproliferative effect of 5-fluorouracil manifests even in a minimal concentration (2 mcg/ml). Recovery of fibroblast proliferative activity after elimination of 5-fluorouracil occurs in concentration under 63 mcg/ml.
Kriukov
A I
AI
Sharkov
S M
SM
Shubin
M N
MN
Kalashnikova
E A
EA
Khamzalieva
R B
RB
Akhmedov
Sh M
ShM
D002465:Cell Movement / Q000187:drug effects; D002921:Cicatrix / Q000517:prevention & control*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005472:Fluorouracil / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D066298:In Vitro Techniques; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D011184:Postoperative Period; D013997:Time Factors
D007166:Immunosuppressive Agents; D005472:Fluorouracil
Eksperimental'noe obosnovanie profilaktiki posleoperatsionnykh rubtsovykh protsessov v otorinolaringologii.