Drug sensitivity of Leishmania species: some unresolved problems.
Leishmania species show a significant variation in their sensitivity to established and experimental drugs. Molecular techniques to identify species in clinical infections rapidly could be used to guide treatment. Molecular markers are required to detect and monitor acquired resistance to antimonial drugs. Reporter genes and the polymerase chain reaction will improve assays both in vitro and in vivo for the identification and evaluation of new drugs.
Croft
Simon L
SL
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. simon.croft@lshtm.ac.uk
Yardley
Vanessa
V
Kendrick
Howard
H
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004351:Drug Resistance; D006801:Humans; D007891:Leishmania / Q000145:classification / Q000187:drug effects*; D021261:Parasitic Sensitivity Tests
D000981:Antiprotozoal Agents