title: Memory T-cells in non-lymphoid tissues.
abstract: Recent studies have shown that long-lived memory CD8 T-cell populations can be subdivided into two distinct groups. The central pool of resting memory cells in lymph organs has been extensively analyzed. However, a second subset of partially activated CD8 memory T-cells has recently been identified in non-lymphoid tissues. In respiratory virus models, a strong correlation between the numbers of antigen-specific T-cells in lung tissues and effective protective cellular immunity suggests that boosting the numbers of memory T-cells in non-lymphoid tissues may be a fruitful approach in vaccine development for viral infections.
authors.affiliation: The Trudeau Institute, Saranac Lake, NY 12983, USA.
authors.forename: Linda S
authors.initials: LS
authors.lastname: Cauley
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hogan
authors.forename: David L
authors.initials: DL
authors.lastname: Woodland
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D008168:Lung / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000276:immunology; D010253:Respirovirus Infections / Q000276:immunology; D029082:Sendai virus / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*