title: Peritoneal carcinomatosis and lymph node metastasis are prognostic indicators in patients with Borrmann type IV gastric carcinoma.
abstract: OBJECTIVE
  Having observed a lower survival rate of patients with Borrmann type IV gastric cancer, we attempted to determine its prognostic indicators.
  
  
  METHODS
  A total of 103 patients with Borrmann type IV gastric cancer were evaluated; 604 patients with Borrmann types I, II and III were used as references.
  
  
  RESULTS
  The results showed that Borrmann type IV gastric cancer were larger, had deeper invasion, more lymphatic and vascular invasions, predominant diffuse type and scirrhous stromal reaction, extensive lymph node metastases and peritoneal carcinomatosis. The 5-year survival rate (11.3%) was significantly lower than that of others (44.7%, P < 0.001). Univariate and multivariate analyses of survival showed that peritoneal carcinomatosis and lymph node metastasis were independently associated with a relative risk of 1.8 and 1.4, respectively. The survival rates of 46 patients with potential curative disease were similar, regardless of various extents of resection.
  
  
  CONCLUSIONS
  Peritoneal carcinomatosis and lymph node metastases are prognostic indicators in patients with Borrmann type IV gastric cancer. Optimal surgical strategy for Borrmann type IV gastric cancer remains unclear.
authors.affiliation: Department of Surgery, Taipei-Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan, Republic of China.
authors.forename: Chin-Yau
authors.initials: CY
authors.lastname: Chen
authors.forename: Chew-Wen
authors.initials: CW
authors.lastname: Wu
authors.forename: Su-Shun
authors.initials: SS
authors.lastname: Lo
authors.forename: Mao-Chin
authors.initials: MC
authors.lastname: Hsieh
authors.forename: Wing-Yiu
authors.initials: WY
authors.lastname: Lui
authors.forename: King-Han
authors.initials: KH
authors.lastname: Shen
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D000368:Aged; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010534:Peritoneal Neoplasms / Q000556:secondary*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D016019:Survival Analysis