The mRNA assembly line: transcription and processing machines in the same factory.
Processing of RNA precursors to their mature form often occurs co-transcriptionally. Consequently, the ternary complex of DNA template, RNA polymerase and nascent RNA chain is the physiological substrate for factors that modify the nascent RNA by capping, splicing and cleavage/polyadenylation. mRNA production is thought to occur within a "factory" that contains the RNA polymerase II transcription machine and the processing machines. Newly discovered protein-protein contacts between RNA polymerase and factors that process mRNA precursors are beginning to illuminate how the "mRNA factory" works.
Bentley
David
D
Department of Biochemistry and Molecular Genetics, UCHSC, B121, 4200 East 9th Avenue, Denver, CO 80262, USA. david.bentley@UCHSC.edu
D020413:3' Untranslated Regions; D000818:Animals; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000378:metabolism; D011401:Promoter Regions, Genetic; D012315:RNA Caps / Q000378:metabolism; D012319:RNA Polymerase II / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012326:RNA Splicing; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000378:metabolism*; D017381:Spliceosomes / Q000378:metabolism; D014158:Transcription, Genetic
D020413:3' Untranslated Regions; D009687:Nuclear Proteins; D012315:RNA Caps; D012333:RNA, Messenger; D012319:RNA Polymerase II