Prognostic significance of CD34 expression in early cervical squamous cell carcinoma.
The aim of the study was to evaluate angiogenesis as an independent prognostic factor and to determine the correlation of the microvessel density (MD) with lymph node metastases and survival rate in 73 women operated because of invasive squamous cell carcinoma (SCC) of the uterine cervix at clinical stages lb and IIa (FIGO). The patients were divided into two groups: I--25 (34.4%) with survival rate <5 years and II--48 (65.6%) with survival rate >5 years. Angiogenesis was quantified in light microscope using an assay for CD34. The CD34 antibody intensely immunostained single endothelial cells as well as larger microvessels. In the study. differences were revealed by comparing the MD between both groups. The 5-year overall survival rate for patients with high MD was significantly worse than for those with low MD (p<0.003). A correlation was found between angiogenesis intensity and vascular involvement as well as the incidence of lymph node metastases. Thus, tissue expression of CD34 in SCC appears to be a significant prognostic indicator.
Lenczewski
A
A
Department of Pathophysiology of Pregnancy, Medical Academy, Białystok, Poland.
Terlikowski
S J
SJ
Sulkowska
M
M
Famulski
W
W
Sulkowski
S
S
Kulikowski
M
M
D000328:Adult; D018952:Antigens, CD34 / Q000096:biosynthesis*; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000401:mortality* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000473:pathology; D011379:Prognosis; D012039:Regional Blood Flow; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000098:blood supply / Q000276:immunology* / Q000473:pathology*
D018952:Antigens, CD34; D014408:Biomarkers, Tumor