Epitope identification and vaccine design for cancer immunotherapy.
The development of processes for engineering multi-epitope vaccines based on the identification and selection of epitope packages, along with vaccine design optimization using epitope placements and spacers to optimize processing efficacy, are reviewed. The Epimmune Inc epitope identification process has been applied to numerous cancer types, but also applies to infectious diseases. Epitope-analog efforts in novel vaccine design have also been explored and their uses in prophylactic and therapeutic applications are eagerly anticipated.
Sette
Alessandro
A
Epimmune Inc, San Diego, CA 92121, USA. asette@epimmune.com
Keogh
Elissa
E
Ishioka
Glenn
G
Sidney
John
J
Tangri
Shabnam
S
Livingston
Brian
B
McKinney
Denise
D
Newman
Mark
M
Chesnut
Robert
R
Fikes
John
J
D000818:Animals; D000939:Epitopes / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D016233:Immunotherapy, Active / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology
D000939:Epitopes