Joining the cell survival squad: an emerging role for protein kinase CK2.
Protein kinase CK2 (formerly known as casein kinase 2) is a serine/threonine protein kinase whose functions have been under investigation for over three decades, leading to the recognition that it interacts with several signaling pathways. Recent demonstrations of signal-mediated dynamic localization of CK2 and the identification of new signaling targets for it have converged to indicate an unexpected function for this protein kinase: cell survival. Here, we summarize our emerging knowledge about how CK2 might participate in the transduction of survival signals.
Ahmed
Khalil
K
Cellular and Molecular Biochemistry Research Laboratory (151), Minneapolis Veterans Affairs Medical Center, Dept Laboratory Medicine and Pathology, MN 55417, USA. ahmedk@umn.edu
Gerber
Delphine A
DA
Cochet
Claude
C
D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology; D047390:Casein Kinase II; D002455:Cell Division; D002470:Cell Survival; D018360:Crystallography, X-Ray; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D009369:Neoplasms / Q000201:enzymology; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry* / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D015398:Signal Transduction
D047390:Casein Kinase II; D017346:Protein Serine-Threonine Kinases