title: Hydrolysis in pharmaceutical formulations.
abstract: This literature review presents hydrolysis of active pharmaceutical ingredients as well as the effects on dosage form stability due to hydrolysis of excipients. Mechanisms and measurement methods are discussed and recommendations for formulation stabilization are listed.
authors.affiliation: Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. ken_waterman@groton.pfizer.com
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Waterman
authors.forename: Roger C
authors.initials: RC
authors.lastname: Adami
authors.forename: Karen M
authors.initials: KM
authors.lastname: Alsante
authors.forename: Amy S
authors.initials: AS
authors.lastname: Antipas
authors.forename: Dan R
authors.initials: DR
authors.lastname: Arenson
authors.forename: Rebecca
authors.initials: R
authors.lastname: Carrier
authors.forename: Jinyang
authors.initials: J
authors.lastname: Hong
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Landis
authors.forename: Franco
authors.initials: F
authors.lastname: Lombardo
authors.forename: Jaymin C
authors.initials: JC
authors.lastname: Shah
authors.forename: Evgenyi
authors.initials: E
authors.lastname: Shalaev
authors.forename: Scott W
authors.initials: SW
authors.lastname: Smith
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
mesh_terms: D002021:Buffers; D002384:Catalysis; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D004349:Drug Packaging; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008956:Models, Chemical; D011355:Prodrugs / Q000378:metabolism; D013535:Suspensions
chemical_list: D002021:Buffers; D004304:Dosage Forms; D005079:Excipients; D011355:Prodrugs; D013535:Suspensions