title: Outside and in: development of neuronal excitability.
abstract: Investigation of the development of excitability has revealed that cells are often specialized at early stages to generate Ca(2+) transients. Studies of excitability have converged on the central role of Ca(2+) and K(+) channels in the plasmalemma that regulate Ca(2+) influx and have identified critical functions for receptor-activated channels in the endoplasmic reticulum that allow efflux of Ca(2+) from intracellular stores. The parallels between excitability in these two locations motivate future work, because comparison of their properties identifies shared attributes.
authors.affiliation: Neurobiology Section 0357, Biology Division, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0357, USA.
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Spitzer
authors.forename: Paul A
authors.initials: PA
authors.lastname: Kingston
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Manning
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Conklin
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000378:metabolism / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D015222:Sodium Channels / Q000378:metabolism / Q000502:physiology
chemical_list: D015220:Calcium Channels; D015222:Sodium Channels