title: CD200 and membrane protein interactions in the control of myeloid cells.
abstract: OX2 (now designated CD200) is a membrane protein expressed by a broad range of cell types. It is the ligand for a receptor restricted to myeloid cells, with the potential to deliver inhibitory signals. This is indicated by the CD200-deficient mouse model, in which myeloid cells are more activated when stimulated immunologically than cells from normal mice. The unusual tissue distribution of CD200 indicates where myeloid cells can be restrictively controlled through cell-cell contact. Recent data on CD200 will be reviewed in the context of other proteins that might have similar roles, in particular, the interaction between CD47 and SIRPalpha (CD172a).
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, OX1 3RE, Oxford, UK. barclay@molbiol.ox.ac.uk
authors.forename: A Neil
authors.initials: AN
authors.lastname: Barclay
authors.forename: Gavin J
authors.initials: GJ
authors.lastname: Wright
authors.forename: Gary
authors.initials: G
authors.lastname: Brooke
authors.forename: Marion H
authors.initials: MH
authors.lastname: Brown
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism; D000943:Antigens, Differentiation; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D051928:CD47 Antigen; D002352:Carrier Proteins / Q000276:immunology / Q000378:metabolism; D002462:Cell Membrane / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007107:Immune System / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D008024:Ligands; D008262:Macrophage Activation; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008954:Models, Biological; D018716:Molecular Mimicry; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism*; D019006:Neural Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D064446:Orexin Receptors; D010053:Ovary / Q000378:metabolism; D011487:Protein Conformation; D051381:Rats; D043562:Receptors, G-Protein-Coupled; D011971:Receptors, Immunologic; D018013:Receptors, Neuropeptide / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014780:Viruses / Q000737:chemistry
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D000954:Antigens, Surface; D051928:CD47 Antigen; C497894:CD47 protein, human; D002352:Carrier Proteins; C497895:Cd47 protein, mouse; D008024:Ligands; D008562:Membrane Glycoproteins; D019006:Neural Cell Adhesion Molecules; D064446:Orexin Receptors; C501922:Sirpa protein, mouse; D043562:Receptors, G-Protein-Coupled; D011971:Receptors, Immunologic; D018013:Receptors, Neuropeptide; C501920:SIRPA protein, human; C501924:Sirpa protein, rat; C042739:antigens, CD200