title: Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q10, nicotinamide, riboflavin and pantothenic acid in the rat.
abstract: A coformulation of essential factors, i.e. propionyl-L-carnitine (PLC), coenzyme Q10 (CoQ10), nicotinamide (NAM), riboflavin and pantothenic acid, was administered orally to Wistar rats for 7 weeks and its efficacy was tested through in vivo and in vitro techniques in improving motor functions of striated, cardiac and smooth musculature of the rat. In vivo experiments showed that long-term supplementation significantly improved horizontal locomotor activity by about 19% in male and 26% in female rats. Maximum values of shortening velocity, work and power were significantly increased (P<.05) in papillary muscle isolated from treated rats. A positive inotropic effect was also observed on colonic smooth muscle strips upon treatment. Work was the most affected parameter and it increased by 160% in smooth muscle from treated animals. The present results indicate that supplementation with the combination of the above mentioned substances elicits positive functional changes on motor performance of skeletal, cardiac and smooth muscle of the rat.
authors.affiliation: Section of Human Physiology and Nutrition, Department of Applied Sciences to Biosystems, University of Cagliari, Via Porcell 4, I-09124, Cagliari, Italy.
authors.forename: Romina
authors.initials: R
authors.lastname: Vargiu
authors.forename: Donatella
authors.initials: D
authors.lastname: Licheri
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Carcassi
authors.forename: Silvia
authors.initials: S
authors.lastname: Naimi
authors.forename: Maria
authors.initials: M
authors.lastname: Collu
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Littarru
authors.forename: Rino
authors.initials: R
authors.lastname: Mancinelli
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002331:Carnitine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003067:Coenzymes; D004338:Drug Combinations; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D009130:Muscle, Smooth / Q000187:drug effects; D009536:Niacinamide / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010205:Pantothenic Acid / Q000494:pharmacology*; D010210:Papillary Muscles / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012256:Riboflavin / Q000494:pharmacology*; D012727:Sex Characteristics; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D003067:Coenzymes; D004338:Drug Combinations; D014451:Ubiquinone; C003223:propionylcarnitine; D010205:Pantothenic Acid; D009536:Niacinamide; C024989:coenzyme Q10; D002331:Carnitine; D012256:Riboflavin