title: A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas.
abstract: The lipoma preferred partner (LPP) gene is fused to the high mobility group protein gene HMGIC in lipomas and pulmonary chondroid hamartomas. In addition, a fusion of LPP to the mixed lineage leukemia (MLL) gene has been described in a case of acute myeloid leukemia. Herein, a novel LPP fusion transcript of LPP in a lipoma is described that points to the possible oncogenic potential of LPP.
authors.affiliation: Center of Human Genetics, University of Bremen, Bremen, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Lemke
authors.forename: P
authors.initials: P
authors.lastname: Rogalla
authors.forename: J
authors.initials: J
authors.lastname: Bullerdiek
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D003598:Cytoskeletal Proteins / Q000235:genetics*; D005260:Female; D006222:Hamartoma / Q000235:genetics*; D006609:High Mobility Group Proteins / Q000235:genetics*; D006801:Humans; D060588:LIM Domain Proteins; D008067:Lipoma / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics*; D008969:Molecular Sequence Data; D015514:Oncogene Proteins, Fusion; D022821:RNA Splice Sites / Q000235:genetics
chemical_list: D003598:Cytoskeletal Proteins; D006609:High Mobility Group Proteins; D060588:LIM Domain Proteins; C103594:LPP protein, human; D015514:Oncogene Proteins, Fusion; D022821:RNA Splice Sites