Application of hydroalcoholic solutions of formaldehyde in preparation of acetylsalicylic acid gastro-resistant capsules.
Enteric coating of hard gelatin capsules by application of hydroalcoholic solutions of formaldehyde was studied and developed in accordance with previous publications. It is possible to affirm that this coating constitutes a simple, stable, reproducible, and inexpensive method, being a valid alternative to those which have been proposed. The aim of the present investigation is the preparation of acetylsalicylic acid gelatin capsules with good conditions of gastro-resistance and enteros solubility.
Pina
M E
ME
Laboratory of Galenic and Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Portugal.
Sousa
A T
AT
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D001241:Aspirin / Q000737:chemistry*; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D003432:Cross-Linking Reagents / Q000737:chemistry; D004355:Drug Stability; D000431:Ethanol; D005079:Excipients / Q000737:chemistry; D005404:Fixatives / Q000737:chemistry*; D005557:Formaldehyde / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry; D012995:Solubility; D012997:Solvents; D013608:Tablets, Enteric-Coated
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002214:Capsules; D003432:Cross-Linking Reagents; D005079:Excipients; D005404:Fixatives; D012997:Solvents; D013608:Tablets, Enteric-Coated; D005557:Formaldehyde; D000431:Ethanol; D005780:Gelatin; D001241:Aspirin