title: Neisseria lactamica protects against experimental meningococcal infection.
abstract: Immunological and epidemiological evidence suggests that the development of natural immunity to meningococcal disease results from colonization of the nasopharynx by commensal Neisseria spp., particularly with N. lactamica. We report here that immunization with N. lactamica killed whole cells, outer membrane vesicles, or outer membrane protein (OMP) pools and protected mice against lethal challenge by a number of diverse serogroup B and C meningococcal isolates in a model of bacteremic infection. Sera raised to N. lactamica killed whole cells, OMPs, or protein pools were found to cross-react with meningococcal isolates of a diverse range of genotypes and phenotypes. The results confirm the potential of N. lactamica to form the basis of a vaccine against meningococcal disease.
authors.affiliation: Centre for Applied Microbiology and Research, Salisbury SP4 0JG, United Kingdom.
authors.forename: Kerry J
authors.initials: KJ
authors.lastname: Oliver
authors.forename: Karen M
authors.initials: KM
authors.lastname: Reddin
authors.forename: Philippa
authors.initials: P
authors.lastname: Bracegirdle
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Hudson
authors.forename: Ray
authors.initials: R
authors.lastname: Borrow
authors.forename: Ian M
authors.initials: IM
authors.lastname: Feavers
authors.forename: Andrew
authors.initials: A
authors.lastname: Robinson
authors.forename: Keith
authors.initials: K
authors.lastname: Cartwright
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Gorringe
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D016470:Bacteremia / Q000276:immunology / Q000517:prevention & control*; D003429:Cross Reactions; D004195:Disease Models, Animal; D006801:Humans; D008589:Meningococcal Infections / Q000276:immunology / Q000517:prevention & control*; D051379:Mice; D009343:Neisseria / Q000276:immunology*; D009345:Neisseria meningitidis / Q000276:immunology* / Q000302:isolation & purification; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial