title: [Advanced prostatic carcinoma with low levels of serum prostate-specific antigen].
abstract: The serum levels of prostate-specific antigen (PSA) represent a significant diagnostic and monitoring parameter of prostatic carcinoma (PC). The aim of the study was to establish correlation of serum PSA level in addition to grade, histological type, and clinical stage of PC in patients with normal or intermediary PSA serum level. In 37 untreated PC patients with preoperative serum PSA levels ranging between 0.1 and 9.6 ng/ml, paraffin-embedded tissue and serum samples were immunohistologically studied and immunoassay for PSA was done. The most representative was poorly differentiated PC with D stage. In serum samples from PC patients 27 (73.7%) normal (< or = 4.0 ng/ml), and 10 (27.3%) intermediate (4.1-10 ng/ml) PSA levels were found. Immunohistochemistry, in 36 PC (97.3%) had demonstrated the expression of PSA. Our study results had shown low serum PSA levels in some patients with advanced poorly differentiated PC.
authors.forename: Snezana
authors.initials: S
authors.lastname: Cerović
authors.forename: Vujadin
authors.initials: V
authors.lastname: Tatić
authors.forename: Jovan
authors.initials: J
authors.lastname: Dimitrijević
authors.forename: Srbislav
authors.initials: S
authors.lastname: Ilić
authors.forename: Novak
authors.initials: N
authors.lastname: Milović
authors.forename: Predrag
authors.initials: P
authors.lastname: Aleksić
authors.forename: Goran
authors.initials: G
authors.lastname: Brajusković
mesh_terms: D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology*
chemical_list: D017430:Prostate-Specific Antigen
vernacular_title: Uznapredovali karcinomi prostate sa niskim serumskim vrednostima prostata-specificnog antigena.