Change in cognitive functioning associated with apoE genotype in a community sample of older adults.
The influence of a genetic risk factor, apolipoprotein E (apoE) epsilon4 variant, was assessed in older adults aged 70 to 94 on 3 occasions over 7 years. The results of latent growth curve analyses are reported for individuals genotyped for apoE at the 2nd measurement occasion (n = 601) and for a subsample of individuals without probable or definite dementia during the 1st or 2nd occasion (n = 434). ApoE-epsilon4 status was a significant predictor of level and change in memory performance and change in speed performance in the full sample, and of initial level and change in memory performance in the nondemented subsample. These results support previous findings that apoE-epsilon4 is associated with accelerated memory deterioration in individuals without clinical dementia.
Hofer
Scott M
SM
Department of Human Development and Family Studies, Pennsylvania State University, University Park 16802, USA. smh21@psu.edu
Christensen
Helen
H
Mackinnon
Andrew J
AJ
Korten
Ailsa E
AE
Jorm
Anthony F
AF
Henderson
Alexander S
AS
Easteal
Simon
S
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics / Q000523:psychology*; D001057:Apolipoproteins E / Q000235:genetics*; D003072:Cognition Disorders / Q000235:genetics / Q000503:physiopathology; D003704:Dementia / Q000235:genetics* / Q000503:physiopathology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000235:genetics* / Q000503:physiopathology*; D012307:Risk Factors
D001057:Apolipoproteins E