title: Usefulness of the modified lavage technique of Bingisser and KL-6 monitoring in a patient with pulmonary alveolar proteinosis.
abstract: A 48-year-old man diagnosed as pulmonary alveolar proteinosis (PAP) received a whole-lung lavage by the conventional lavage technique, but he failed to show any clinical or functional improvement. Therefore, we applied a modified lavage technique of Bingisser resulting in the impressive clinical and functional improvement. We measured the levels of KL-6 in bronchoalveolar lavage fluid (BALF) at selected time intervals. KL-6 levels in BALF were higher during the lavage by the modified lavage technique of Bingisser than the conventional lavage technique. We were able to verify the usefulness of the modified lavage technique of Bingisser by monitoring the levels of KL-6 in BALF. The modified lavage technique of Bingisser may be useful for PAP treatment.
authors.affiliation: Second Department of Internal Medicine, Hiroshima University Faculty of Medicine.
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Ishikawa
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kondo
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Oguri
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kamitsuna
authors.forename: Joji
authors.initials: J
authors.lastname: Sakurai
authors.forename: Kazunori
authors.initials: K
authors.lastname: Fujitaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Maeda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Isobe
authors.forename: Nobuoki
authors.initials: N
authors.lastname: Kohno
mesh_terms: D000941:Antigens / Q000032:analysis*; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000032:analysis; D018893:Bronchoalveolar Lavage / Q000379:methods*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins / Q000032:analysis; D011649:Pulmonary Alveolar Proteinosis / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins