Application of gene expression profiling to cardiovascular disease.
The number of cardiovascular publications featuring gene expression profiling technologies is growing rapidly. This article introduces four profiling techniques; serial analysis of gene expression, differential display, subtractive hybridisation and DNA microarrays. Illustrations of their application towards cardiovascular research are given and their potential for gene discovery and improving our understanding of gene function is discussed.
Henriksen
P A
PA
Division of Bio-Medical Sciences, Room 323a, Hugh Robson Building, University of Edinburgh, George Square, EH8 9XD, UK.
Kotelevtsev
Y
Y
D000818:Animals; D002318:Cardiovascular Diseases / Q000196:embryology / Q000209:etiology / Q000235:genetics*; D002478:Cells, Cultured; D020869:Gene Expression Profiling; D006801:Humans; D007091:Image Processing, Computer-Assisted; D023421:Models, Animal; D009206:Myocardium / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction