Improvement of a biomimetic porphyrin catalytic system by addition of acids.
The conditions of the use of the manganese/porphyrin/imidazole system needed to be improved in order to obtain larger amounts of models of metabolites. An increase of the oxidation yields and a better preservation of this catalytic system have been obtained on the examples of various alkanes, by an acid addition in the reaction mixture. Three manganoporphyrins were checked for evaluation of the reaction. These results were extended to molecules of therapeutical interest such as ibuprofen and phenylbutazone.
Segrestaa
Jérôme
J
Laboratoire de Pharmacochimie, Département de Chimie Organique, Faculté de Médecine et de Pharmacie de Rouen, France.
Vérité
Philippe
P
Estour
François
F
Ménager
Sabine
S
Lafont
Olivier
O
D000893:Anti-Inflammatory Agents / Q000737:chemistry; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D005561:Formates / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D011166:Porphyrins / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D001555:Benzene Derivatives; D005561:Formates; D016877:Oxidants; D011166:Porphyrins; C030544:formic acid; D006861:Hydrogen Peroxide; C004912:ethylbenzene