Synthesis and biological activity of hydroxamic acid-derived vasopeptidase inhibitor analogues.
[structure: see text] Syntheses of novel hydroxamic acid-derived azepinones containing pendant mercaptoacyl groups or formyl hydroxamates are described. These new analogues of therapeutically important ACE and NEP inhibitors include unprecedented changes at the previously assumed essential acid component.
Walz
Andrew J
AJ
Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Miller
Marvin J
MJ
D000818:Animals; D006801:Humans; D006877:Hydroxamic Acids / Q000737:chemistry*; D010447:Peptide Hydrolases / Q000187:drug effects*; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011817:Rabbits
D006877:Hydroxamic Acids; D011480:Protease Inhibitors; D010447:Peptide Hydrolases