Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.
Recent technological breakthroughs allowing for large-scale analysis of gene transcripts and large-scale monitoring of the immune response with protein chips are revealing new participants in the pathogenesis of multiple sclerosis. Some of these participants may be useful targets for therapy.
Steinman
Lawrence
L
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California 94305, USA. steinman@stanford.edu
Martin
Roland
R
Bernard
Claude
C
Conlon
Paul
P
Oksenberg
Jorge R
JR
D000818:Animals; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology* / Q000628:therapy; D009186:Myelin Sheath / Q000276:immunology* / Q000473:pathology
D018836:Inflammation Mediators