At least thirty-four days of animal continuous perfusion by a newly developed extracorporeal membrane oxygenation system without systemic anticoagulants.
We developed an extracorporeal membrane oxygenation (ECMO) system with high antithrombogenicity and durability characteristics for prolonged continuous cardiopulmonary support. The oxygenator consists of a special hollow-fiber-type polyolefin gas-exchange membrane, which has an ultrathin dense layer in contact with the blood, in order to prevent plasma leakage during protracted use (Platinum Cube NCVC). The centrifugal pump (RotaFlow) is free of seals. The entire blood-contacting surface of the system is coated with a newly developed heparin material (Toyobo-NCVC coating). We performed a venoarterial bypass in a goat, and the ECMO system was driven for 34 days without systemic anticoagulants. Plasma leakage from the oxygenator did not occur, and sufficient gas exchange performance was maintained. Thrombus formation was hardly observed in the ECMO system except in the casing margins of the oxygenator. This ECMO system showed potential for long-term cardiopulmonary support with minimal or no use of systemic anticoagulants.
Nishinaka
Tomohiro
T
Department of Artificial Organs, National Cardiovascular Center, Osaka, Japan. nishinak@ri.ncvc.go.jp
Tatsumi
Eisuke
E
Taenaka
Yoshiyuki
Y
Katagiri
Nobumasa
N
Ohnishi
Hiroyuki
H
Shioya
Kyoko
K
Fukuda
Toshihide
T
Oshikawa
Mitsuo
M
Sato
Koichi
K
Tsukiya
Tomonori
T
Homma
Akihiko
A
Takewa
Yoshiaki
Y
Takano
Hisateru
H
Sato
Masaki
M
Kashiwabara
Susumu
S
Tanaka
Hidenori
H
Sakai
Kazunari
K
Matsuda
Toshiaki
T
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D006041:Goats; D006323:Heart Arrest / Q000628:therapy*; D010477:Perfusion / Q000295:instrumentation*; D012131:Respiratory Insufficiency / Q000628:therapy*; D013997:Time Factors
D000925:Anticoagulants