title: Inhibitors of antibiotic efflux pump in resistant Enterobacter aerogenes strains.
abstract: Enterobacter aerogenes, a nosocomial pathogen, is frequently exhibiting multidrug resistance mechanisms associated with a change in membrane permeability. In clinical isolates, active efflux plays a prominent role in antibiotic resistance. We report here the effect of three unrelated compounds that are able to restore a noticeable antibiotic susceptibility to resistant strains. The targeting of various parameters which contribute to the efficacy of the efflux mechanism, such as energy, flux selectivity, or functional assembly of the membrane complex, increases the intracellular chloramphenicol concentration in resistant isolates.
authors.affiliation: EA2197, IFR48, Faculté de Médecine, Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
authors.forename: Monique
authors.initials: M
authors.lastname: Malléa
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Chevalier
authors.forename: Annie
authors.initials: A
authors.lastname: Eyraud
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Pagès
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002701:Chloramphenicol / Q000378:metabolism / Q000493:pharmacokinetics; D021902:Enterobacter aerogenes / Q000737:chemistry / Q000378:metabolism*; D010455:Peptides; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D002701:Chloramphenicol; C017339:globomycin