title: Improvement of a biomimetic porphyrin catalytic system by addition of acids.
abstract: The conditions of the use of the manganese/porphyrin/imidazole system needed to be improved in order to obtain larger amounts of models of metabolites. An increase of the oxidation yields and a better preservation of this catalytic system have been obtained on the examples of various alkanes, by an acid addition in the reaction mixture. Three manganoporphyrins were checked for evaluation of the reaction. These results were extended to molecules of therapeutical interest such as ibuprofen and phenylbutazone.
authors.affiliation: Laboratoire de Pharmacochimie, Département de Chimie Organique, Faculté de Médecine et de Pharmacie de Rouen, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Segrestaa
authors.forename: Philippe
authors.initials: P
authors.lastname: Vérité
authors.forename: François
authors.initials: F
authors.lastname: Estour
authors.forename: Sabine
authors.initials: S
authors.lastname: Ménager
authors.forename: Olivier
authors.initials: O
authors.lastname: Lafont
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D005561:Formates / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D011166:Porphyrins / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D001555:Benzene Derivatives; D005561:Formates; D016877:Oxidants; D011166:Porphyrins; C030544:formic acid; D006861:Hydrogen Peroxide; C004912:ethylbenzene