[The role of alphavbeta3 integrin in changes of the invasive phenotype in CP-transformed fibroblasts with multiple drug resistance].
A line of Syrian hamster RSV-ransformed fibroblasts having resistance to a number of cytostatics was shown to differ from the parental drug-sensitive line by an extremaly low expression of the integrin alpha v beta 3. In vitro invasive activity of the drug-resistrant cells appeared to be lower than that of their drug-sensitive counterparts. The role of integrin alpha v beta 3 in malignant phenotype and multiple drug resistance of tumor cells is discussed.
Morozevich
G E
GE
Institute of Biomedical Chemistry by V.N. Orekchovich, RAMS, Moscow.
Kozlova
N I
NI
Chubukina
A N
AN
Berman
A E
AE
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002448:Cell Adhesion; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D018432:Drug Resistance, Multiple / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D016326:Extracellular Matrix Proteins / Q000502:physiology; D005347:Fibroblasts / Q000378:metabolism; D018093:Gelatinases / Q000378:metabolism; D009361:Neoplasm Invasiveness; D010641:Phenotype; D019030:Receptors, Vitronectin / Q000378:metabolism*
D000970:Antineoplastic Agents; D016326:Extracellular Matrix Proteins; D019030:Receptors, Vitronectin; D018093:Gelatinases
Rol' integrina alphavbeta3 v izmenenii invazivnogo fenotipa v CP-transformirovannykh fibroblastov, obladaiushchikh mnozhestvennoĭ lekarstvennoĭ ustoĭchivost'iu.