[Gene expression profiles in the diagnosis and prognosis of cancer].
DNA-microarray technology can be used to assess the expression of several thousands of genes at the same time. The identification of the gene expression profiles may help to better characterize human cancer. These studies may reveal subclasses of tumor types with similar histopathologic profile but different clinical courses.Furthermore,such studies could help to define therapeutic sensitivity and to estimate prognosis of various cancers. Identification of gene expression profiles of cancer can identify new therapeutic targets or cancer susceptibility genes. The DNA-microarray technology may write a new chapter in molecular oncology.
Kopper
László
L
I.sz.Patológiai és Kísérleti Rákkutató Intézet, Semmelweis Egyetem, Budapest, H1085, Hungary. kopper@korb1.sote.hu
Tímár
József
J
D000970:Antineoplastic Agents / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm / Q000235:genetics*; D015316:Genetic Therapy; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000235:genetics; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000235:genetics; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm
Génexpressziós profil a szolid tumorok diagnosztikájában és prognosztikájában.