Synthesis and antioxidant activity of 3-substituted guaiazulene derivatives.
A series of 3-substituted guaiazulene derivatives has been synthesized and their antioxidant properties were evaluated by monitoring their capacity for scavenging the stable free-radical DPPH. 3-Vinylguaiazulene was the most potent, possessing antioxidant activity superior than alpha-tocopherol. These derivatives were also moderate inhibitors of the proliferation of human promyelocytic leukemia cells.
Pratsinis
Harris
H
Laboratory of Cell Proliferation and Ageing, Institute of Biology, NCSR Demokritos, Athens, Greece.
Haroutounian
Serkos A
SA
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D052176:Azulenes; D002384:Catalysis; D004354:Drug Screening Assays, Antitumor; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000382:microbiology; D015227:Lipid Peroxidation / Q000187:drug effects; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045789:Sesquiterpenes, Guaiane; D013936:Thymidine / Q000494:pharmacology; D013997:Time Factors; D024502:alpha-Tocopherol / Q000737:chemistry / Q000494:pharmacology
C459145:3-formylguaiazulene; C459144:3-vinylguaiazulene; D000970:Antineoplastic Agents; D000975:Antioxidants; D052176:Azulenes; D016166:Free Radical Scavengers; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C004451:guaiazulene; D024502:alpha-Tocopherol; D013936:Thymidine