Ofuji's disease: a report on 20 patients with clinical and histopathologic analysis.
BACKGROUND
Ofuji's disease, also referred to as classic eosinophilic pustular folliculitis, is a rare dermatosis of unknown origin for which there is no uniformly effective treatment.


OBJECTIVE
Twenty patients with Ofuji's disease (classic eosinophilic pustular folliculitis) evaluated in our department from January 1978 to June 1999 were studied clinically and histopathologically. Laboratory data, treatments, and clinical courses were evaluated in 12 of these individuals.


RESULTS
Nissl modified staining revealed moderate increases of mast cells around hair follicles and sebaceous glands in all 20 patients; the majority of the infiltrating mast cells were tryptase-positive and chymase-negative. Eight of 11 patients treated with oral indomethacin responded completely.


CONCLUSIONS
Indomethacin is an effective therapy for Ofuji's disease. Tryptase-positive and chymase-negative mast cells might play some role in the pathogenesis of Ofuji's disease.
Ishiguro
Naoko
N
Department of Dermatology, Tokyo Women's Medical University, Japan.
Shishido
Etsuko
E
Okamoto
Reiko
R
Igarashi
Yasuko
Y
Yamada
Mina
M
Kawashima
Makoto
M
D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001132:Arm; D001415:Back; D003622:Dapsone / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D005260:Female; D005499:Folliculitis / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D005528:Foot; D006801:Humans; D007150:Immunohistochemistry; D007213:Indomethacin / Q000627:therapeutic use; D007564:Japan / Q000453:epidemiology; D008297:Male; D008407:Mast Cells / Q000276:immunology; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000627:therapeutic use; D013909:Thorax; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003622:Dapsone; D011239:Prednisolone; D008911:Minocycline; D013420:Sulfamethoxazole; D007213:Indomethacin