[Role of gene polymorphism of catechol-O-methyltransferase (COMT), monoamine oxidase B (MAOB), cytochrome P450 2D6 (CYP2D6) and N-acetyltransferase 2 (NAT2) in pathogenesis of Parkinson's disease].
Factors underlying pathogenesis of diseases are currently being searched. In recent years increasing number of reports on genetic background of central nervous system diseases have appeared. In the search of factors that can precipitate degeneration of dopaminergic neurons the role of enzymes catabolising xenobiotics (CYP2D6, NAT2) and enzymes metabolising catecholamines (COMT, MAO B) has been postulated. Polymorphism of genes coding for isotypes characterised by different biological activity could be responsible for the propensity for Parkinson's disease, progression and efficacy of pharmacotherapy of the disease.
Białecka
Monika
M
Katedry Farmakologii i Toksykologii Pomorskiej Akademii Medycznej w Szczecinie.
Droździk
Marek
M
Podraza
Hanna
H
D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D018450:Disease Progression; D006801:Humans; D008995:Monoamine Oxidase / Q000235:genetics*; D010300:Parkinson Disease / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D015262:Xenobiotics / Q000378:metabolism
D015262:Xenobiotics; D019389:Cytochrome P-450 CYP2D6; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human
Rola polimorfizmu genów katecholo-O-metylotransferazy (COMT), monoaminooksydazy typu B (MAOB) oraz cytochromu P450 2D6 (CYP2D6) i N-acetylotransferazy (NAT2) w patogenezie choroby Parkinsona.