title: Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5 Delta 32 allele.
abstract: Entry of HIV-1 into a cell happens only after viral envelope glycoproteins have bound to CD4 and a chemokine receptor. Generally, macrophage-tropic strains use CCR5, and T cell-line-tropic strains use CXCR4 as coreceptors for virus entry. Dual-tropic viruses can use both CCR5 and CXCR4. About 1% of white people are homozygous for a non-functional CCR5 allele, containing a 32 base pair deletion (CCR5 Delta 32). We studied the persistence of dual-tropic HIV-1 in an individual homozygous for this deletion. Our results suggest that structural features of the HIV-1 envelope linked to CCR5 tropism could confer a selective advantage in vivo.
authors.affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Gorry
authors.forename: Chengsheng
authors.initials: C
authors.lastname: Zhang
authors.forename: Sam
authors.initials: S
authors.lastname: Wu
authors.forename: Kevin
authors.initials: K
authors.lastname: Kunstman
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Trachtenberg
authors.forename: John
authors.initials: J
authors.lastname: Phair
authors.forename: Steven
authors.initials: S
authors.lastname: Wolinsky
authors.forename: Dana
authors.initials: D
authors.lastname: Gabuzda
mesh_terms: D000328:Adult; D000483:Alleles; D018791:CD4 Lymphocyte Count; D016827:CD8 Antigens; D006679:HIV Seropositivity / Q000235:genetics / Q000276:immunology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006720:Homozygote; D006801:Humans; D008297:Male; D019713:Receptors, CCR5 / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D016827:CD8 Antigens; D019713:Receptors, CCR5