title: Cytotoxic and apoptosis-inducing ent-kaurane-type diterpenoids from the Japanese liverwort Jungermannia truncata NEES.
abstract: Five new ent-kaurane-type diterpenoids and a new gymnomitrane (=barbatane)-type sesquiterpenoid have been isolated from the Japanese liverwort Jungermannia truncata NEES, together with twelve previously known ent-kaurane-type diterpenoids. The structures of the new compounds were elucidated by two-dimensional (2D) NMR experiments and chemical reaction. Some of the isolated compounds showed cytotoxicity against human leukemia cell lines and induced apoptosis.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan. fnaga@ph.bunri-u.ac.jp
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Nagashima
authors.forename: Masuo
authors.initials: M
authors.lastname: Kondoh
authors.forename: Toshinari
authors.initials: T
authors.lastname: Uematsu
authors.forename: Akiko
authors.initials: A
authors.lastname: Nishiyama
authors.forename: Sayaka
authors.initials: S
authors.lastname: Saito
authors.forename: Masao
authors.initials: M
authors.lastname: Sato
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
mesh_terms: D017209:Apoptosis; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D007564:Japan; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D004224:Diterpenes