title: Acute psychotic disorders induced by topiramate: report of two cases.
abstract: We report on two epileptic patients who developed acute psychosis after the use of topiramate (TPM). One patient exhibited severe psychomotor agitation, heteroaggressiveness, auditory and visual hallucinations as well as severe paranoid and mystic delusions. The other patient had psychomotor agitation, depersonalization, derealization, severe anxiety and deluded that he was losing his memory. Both patients had to be taken to the casualty room. After interruption of TPM in one patient and reduction of dose in the other, a full remission of the psychotic symptoms was obtained without the need of antipsychotic drugs. Clinicians should be aware of the possibility of development of acute psychotic symptoms in patients undergoing TPM treatment.
authors.affiliation: Instituto de Biociências, Universidade Estadual Paulista, Rio Claro, SP, Brasil.
authors.forename: Florindo
authors.initials: F
authors.lastname: Stella
authors.forename: Dorgival
authors.initials: D
authors.lastname: Caetano
authors.forename: Fernando
authors.initials: F
authors.lastname: Cendes
authors.forename: Carlos A M
authors.initials: CA
authors.lastname: Guerreiro
mesh_terms: D000208:Acute Disease; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D005632:Fructose / Q000009:adverse effects* / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose