title: [The effect of anesthetics on control of respiration].
abstract: Ventilatory control in humans depends on complex mechanisms which aim to maintain a cellular CO2-, O2- and H(+)-homeostasis under physiological conditions. This regulation is based on chemical control which predominantly acts via peripheral chemoreceptors in the carotid bodies and central chemoreceptors in the ventral medulla of the brainstem on the one hand, and behavioural control on the other, by which it is possible to adapt respiration to conditions of daily living. The influence of anaesthesia and related conditions may depress respiration and have a sustained effect on ventilatory control. Perioperative respiratory depression remains a serious clinical problem in perioperative medicine. This review will give an overview of ventilatory control and discuss the most relevant responses, describe the effects of pain, anaesthetics and opioids on ventilatory control and their interaction. The current body of knowledge is put into perspective to identify patients at risk for perioperative respiratory depression.
authors.affiliation: Abteilung für Anästhesiologie, Universitätsklinik Leiden, Leiden, Niederlande.
authors.forename: E
authors.initials: E
authors.lastname: Sarton
authors.forename: R
authors.initials: R
authors.lastname: Romberg
authors.forename: D
authors.initials: D
authors.lastname: Nieuwenhuijs
authors.forename: L J
authors.initials: LJ
authors.lastname: Teppema
authors.forename: J
authors.initials: J
authors.lastname: Vuyk
authors.forename: S
authors.initials: S
authors.lastname: Schraag
authors.forename: A
authors.initials: A
authors.lastname: Dahan
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects; D000777:Anesthetics / Q000009:adverse effects*; D002245:Carbon Dioxide / Q000097:blood; D004347:Drug Interactions; D006801:Humans; D010100:Oxygen / Q000097:blood; D010146:Pain / Q000503:physiopathology; D015656:Respiratory Mechanics / Q000187:drug effects* / Q000502:physiology
chemical_list: D000701:Analgesics, Opioid; D000777:Anesthetics; D002245:Carbon Dioxide; D010100:Oxygen
vernacular_title: Einfluss von Anästhetika auf die Atemkontrolle.