Isoliquiritigenin suppresses pulmonary metastasis of mouse renal cell carcinoma.
Isoliquiritigenin is a chalcone isolated from licorice and shallots. The ability of isoliquiritigenin to suppress metastasis was examined in a pulmonary metastasis model of mouse renal cell carcinoma. Isoliquiritigenin significantly reduced pulmonary metastasis, without any weight loss or leukocytopenia. Isoliquiritigenin suppressed in vitro proliferation of carcinoma cells, potentiated nitric oxide production by lipopolysaccharide-stimulated macrophages, and facilitated cytotoxicity of splenic lymphocytes in vitro. These findings suggest activation of macrophages, activation of cytotoxicity of lymphocytes, and direct cytotoxicity as possible mechanisms of metastasis suppression by isoliquiritigenin. In addition, isoliquiritigenin prevented severe leukocytopenia caused by administration of 5-fluorouracil.
Yamazaki
Shoji
S
Department of Hospital Pharmacy, Jichi Medical School, 3311 Yakushiji, Minamikawachi, Tochigi 329-0498, Japan. s-yama@jichi.ac.jp
Morita
Tatuo
T
Endo
Hitoshi
H
Hamamoto
Toshiro
T
Baba
Masaki
M
Joichi
Yoshiko
Y
Kaneko
Sanae
S
Okada
Yoshihito
Y
Okuyama
Toru
T
Nishino
Hoyoku
H
Tokue
Akihiko
A
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000517:prevention & control / Q000556:secondary*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D047188:Chalcones; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D006035:Glycyrrhiza; D007680:Kidney Neoplasms; D007970:Leukopenia / Q000517:prevention & control; D008070:Lipopolysaccharides / Q000494:pharmacology; D008175:Lung Neoplasms / Q000517:prevention & control* / Q000556:secondary*; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000378:metabolism; D008517:Phytotherapy; D014407:Tumor Cells, Cultured; D015431:Weight Loss / Q000187:drug effects
D000970:Antineoplastic Agents; D047188:Chalcones; D004791:Enzyme Inhibitors; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D002599:Chalcone; C040920:isoliquiritigenin; D005472:Fluorouracil