title: Total synthesis of ecteinascidin 743.
abstract: The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol-aldehyde cyclization, and acid-induced intramolecular sulfide formation.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, The Japan Science and Technology Cooperation (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Endo
authors.forename: Arata
authors.initials: A
authors.lastname: Yanagisawa
authors.forename: Masanao
authors.initials: M
authors.lastname: Abe
authors.forename: Shigemitsu
authors.initials: S
authors.lastname: Tohma
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kan
authors.forename: Tohru
authors.initials: T
authors.lastname: Fukuyama
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis*; D004149:Dioxoles / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis*; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin
chemical_list: D018906:Antineoplastic Agents, Alkylating; D004149:Dioxoles; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin