Impact of high bromide intake in the rat dam on iodine transfer to the sucklings.
A significant impact of high bromide levels in the organism of the mother on iodine transfer to the sucklings was established in experiments with female Wistar rats. The observed decrease in iodine transfer to the young through mothers' milk and/or an increase in the bromide concentration in the milk, caused a decrease in body weight of the pups. Enhanced bromide levels also adversely affected the thyroid gland of the young. High bromide intake in the lactating dams caused a decrease in iodide accumulation in the mammary glands, and also an increase in iodide elimination through the kidneys.
Pavelka
S
S
Institute of Physiology, Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20 Prague 4, Czech Republic. pavelka@biomed.cas.cz
Babický
A
A
Lener
J
J
Vobecký
M
M
D000818:Animals; D000833:Animals, Suckling; D001965:Bromides / Q000008:administration & dosage*; D005260:Female; D007455:Iodine / Q000493:pharmacokinetics*; D008297:Male; D009929:Organ Size; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000033:anatomy & histology; D013963:Thyroid Hormones / Q000097:blood
D001965:Bromides; D013963:Thyroid Hormones; D007455:Iodine