Comparison of corticosteroids for treatment of respiratory syncytial virus bronchiolitis and pneumonia in cotton rats.
Triamcinolone acetonide, methylprednisolone, and dexamethasone were each evaluated in combination with palivizumab (Synagis) for the therapy of established respiratory syncytial virus infection in the cotton rat. Triamcinolone and methylprednisolone proved to be more effective than dexamethasone in reducing lung pathology. No recurrence of viral replication or pulmonary pathology followed the cessation of therapy.
Ottolini
Martin G
MG
Department of Pediatric, F. Edward Hébert School of Medicine of the Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Curtis
Spencer J
SJ
Porter
David D
DD
Mathews
Amy
A
Richardson
Joann Y
JY
Hemming
Val G
VG
Prince
Gregory A
GA
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D001988:Bronchiolitis / Q000188:drug therapy*; D000069455:Palivizumab; D011024:Pneumonia, Viral / Q000188:drug therapy*; D012008:Recurrence; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy*; D016205:Sigmodontinae; D014779:Virus Replication / Q000187:drug effects
D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000069455:Palivizumab