Virus load during primary Human Immunodeficiency Virus (HIV) type 1 infection is related to the severity of acute HIV illness in Kenyan women.
We evaluated the association between the severity of primary human immunodeficiency virus type 1 (HIV-1) illness and HIV-1 plasma virus load before seroconversion using stored plasma samples obtained from 74 prostitutes in Mombasa, Kenya. Fever, vomiting, headache, fatigue, arthralgia, myalgia, sore throat, skin rash, or being too sick to work were each associated with significantly higher virus loads before HIV-1 seroconversion, and each additional symptom or sign was associated with an increase in virus load of 0.4 log(10) copies/mL.
Lavreys
Ludo
L
University of Washington, Seattle, WA, 98104, USA. llavreys@u.washington.edu
Baeten
Jared M
JM
Overbaugh
Julie
J
Panteleeff
Dana D
DD
Chohan
Bhavna H
BH
Richardson
Barbra A
BA
Mandaliya
Kishorchandra
K
Ndinya-Achola
Jeckoniah O
JO
Kreiss
Joan K
JK
D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000503:physiopathology* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D011477:Sex Work; D019562:Viral Load; D016387:Women's Health