title: CD30-positive cutaneous T-cell lymphoma with concurrent solid tumour.
abstract: Extranodal CD30+ T-cell lymphomas seldom carry classical t(2;5) translocation and are usually anaplastic large cell lymphoma kinase protein negative. They cover a wide spectrum of histological and clinical behaviour. The prognosis of CD30+ cutaneous T-cell lymphoma (CTCL) is good in the absence of nodal primary or disseminated disease. These lesions can undergo spontaneous regression, and overlap with the group of lesions of lymphomatoid papulosis. Although an increased incidence of solid tumours has been reported in patients with CD30+ non-Hodgkin lymphoma of the skin, reports of concurrent malignancies are rare in CD30+ CTCL. We report two patients with CD30+ CTCL who, respectively, had concurrent disseminated gastric carcinoma and bilateral ovarian teratoma. Despite an aggressive clinical and histological appearance, both cases ran favourable clinical courses. The CTCL responded completely to chemotherapy in one patient, who eventually succumbed to gastric cancer. In the other patient, lesions regressed spontaneously after bilateral oophorectomy. A possible relationship between the lymphoma and the solid tumours is discussed.
authors.affiliation: Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong. auwing@hotmail.com
authors.forename: W Y
authors.initials: WY
authors.lastname: Au
authors.forename: C K
authors.initials: CK
authors.lastname: Yeung
authors.forename: H H
authors.initials: HH
authors.lastname: Chan
authors.forename: R W M
authors.initials: RW
authors.lastname: Wong
authors.forename: T W
authors.initials: TW
authors.lastname: Shek
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis*; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000276:immunology* / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology; D014594:Uterine Neoplasms / Q000276:immunology* / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen