title: [Birthweight and caffeine consumption].
abstract: OBJECTIVE
  To assess the association between maternal caffeine consumption during pregnancy and low birth weight, prematurity and intrauterine growth retardation.
  
  
  METHODS
  A case-control was carried out and 354 newborns of single labor with birthweight <2,500 g (cases) and 354 with birthweight >3,000 g (controls) were analyzed. Caffeine consumption was calculated based on daily consumption of coffee, soft drinks and tea. Results were adjusted using multiple logistic regression for the following confounders: mother's age, schooling, income, marital status, skin color, parity, smoking, previous low birthweight children, mother's pre-pregnancy weight, employment status, interval between pregnancies, prenatal care and high blood pressure.
  
  
  RESULTS
  For caffeine consumption <300 mg/day and >300 mg/day, the adjusted odds ratios for low birthweight were: 0.72 (95%IC=0.45-1.25) and 0.47 (95%IC=0.24-0.92); prematurity: 0.59 (95%IC=0.32-1.09) and 0.32 (95%IC=0.15-0.72); and intrauterine growth retardation: 1.16 (95%IC=0.45-3.01) and 0.64 (95%IC=0.20-1.98), respectively.
  
  
  CONCLUSIONS
  There was no association between caffeine consumption during pregnancy and low birthweight, prematurity and intrauterine growth retardation.
authors.affiliation: Departamento de Pediatria, Faculdade de Medicina, Universidade Estadual de Campinas, Campinas, SP, Brasil. gripp@dgenet.com.br
authors.forename: Gladys Gripp
authors.initials: GG
authors.lastname: Bicalho
authors.forename: Antônio de Azevedo
authors.initials: Ade A
authors.lastname: Barros Filho
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000187:drug effects*; D002110:Caffeine / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D016017:Odds Ratio; D011247:Pregnancy; D012307:Risk Factors; D012959:Socioeconomic Factors
chemical_list: D002110:Caffeine
vernacular_title: Peso ao nascer e influência do consumo de cafeína.