A case of apolipoprotein C-II deficiency with coronary artery disease.
A 56-year-old male with apolipoprotein C-II deficiency experienced a myocardial infarction without pancreatitis. A coronary angiogram showed complete occlusions of both the right and circumflex coronary arteries. His serum lipid levels were as follows: fasting total cholesterol 3.15 mmol/l; postprandial total cholesterol 3.62 mmol/l; fasting triglycerides 1.46 mmol/A; postprandial triglycerides 6.14 mmol/l; fasting high-density lipoprotein-cholesterol 0.47 mmol/l; and postprandial high-density lipoprotein cholesterol 0.36 mmol/l. His fasting level of plasma apolipoprotein C-II was 0.005 g/l, but his plasma levels of other apolipoproteins were within normal ranges. A DNA sequence analysis of the apolipoprotein C-II gene showed no mutations in exon 1, 2, 3, or 4, where most gene mutations related to apolipoprotein C-II deficiency occur. We report this patient's very rare heterozygous apolipoprotein C-II deficiency with coronary artery disease. Although this patient had some risk factors for coronary artery disease, coronary atherosclerosis in this patient might have occurred as a result of lipoprotein abnormalities caused by at least one mutation in the apolipoprotein C-II gene.
Kawano
M
M
Integrated Medicine, Omiya Medical Center, Jichi Medical School, Saitama, Japan. mkkawano@jichi.ac.jp
Kodama
K
K
Inadera
H
H
Saito
Y
Y
Saito
M
M
Yaginuma
T
T
Kanazawa
Y
Y
Kawakami
M
M
D053304:Apolipoprotein C-II; D001056:Apolipoproteins C / Q000172:deficiency* / Q000235:genetics; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009203:Myocardial Infarction / Q000378:metabolism; D012307:Risk Factors
D053304:Apolipoprotein C-II; D001056:Apolipoproteins C; D008055:Lipids; D002784:Cholesterol