title: Recruitment and development of the follicle; the roles of the transforming growth factor-beta superfamily.
abstract: Peripheral endocrine hormones and local paracrine and autocrine factors contribute, in a coordinated fashion, to the processes of recruitment, development or atresia, selection and ovulation of follicles. Among the local ovarian factors, there is growing evidence from genetic and experimental data that many members of the transforming growth factor (TGFbeta) superfamily have a biological role to play in folliculogenesis. These members include activin, inhibin, TGFbeta, BMP, GDF9 and perhaps MIS. In this review, we discuss the potential roles of the TGFbeta superfamily members, in particular activin, during folliculogenesis. Since the actions of these factors are determined by ligand availability, receptor expression and modulation of their signal transduction pathways, we also collate information on the expression of their signalling components in the follicle. We conclude that the TGFbeta superfamily signalling pathways, in particular activin's pathway, reside in the ovary. Furthermore, follistatin and beta-glycan-components of the accessory binding protein system that modifies activin action-are also present in follicles. In the post-natal rat ovary, the changes in receptor/Smad expression coincide with granulosa cell proliferation and antrum formation. We hypothesise that these pathway components are expressed in a temporal and cell-specific manner to meet the changing demands of cells during follicular development. The analysis of the components of the signal transduction pathways of the TGFbeta family members in populations of defined follicles and the identification of activated pathways in individually stimulated follicles should help clarify the roles of the TGFbeta members in folliculogenesis.
authors.affiliation: Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic. 3168, Australia. jock.findlay@med.monash.edu
authors.forename: J K
authors.initials: JK
authors.lastname: Findlay
authors.forename: A E
authors.initials: AE
authors.lastname: Drummond
authors.forename: M L
authors.initials: ML
authors.lastname: Dyson
authors.forename: A J
authors.initials: AJ
authors.lastname: Baillie
authors.forename: D M
authors.initials: DM
authors.lastname: Robertson
authors.forename: J-F
authors.initials: JF
authors.lastname: Ethier
mesh_terms: D029404:Activin Receptors / Q000235:genetics / Q000378:metabolism; D028341:Activins / Q000378:metabolism; D000818:Animals; D019898:Autocrine Communication / Q000502:physiology; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D008024:Ligands; D005810:Multigene Family; D006080:Ovarian Follicle / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D019899:Paracrine Communication / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D019485:Bone Morphogenetic Proteins; D008024:Ligands; D016212:Transforming Growth Factor beta; D028341:Activins; D029404:Activin Receptors