[Effects of nitric oxide on myocardial contraction function].
Nitric oxide (NO) produced by myocardial nitric oxide synthase has been implicated as a modulator of myocardial contraction [correction of contracion]. This paper reviewed the reports on myocardial contraction modulated by NO, its mechanism, and regulation of expression and activity of iNOS. NO was recently shown to produce biphasic contractile [correction of contratile] effects on myocardium: augmentation at low levels and depression at high levels. The up-regulation of inducible nitric oxide synthase (iNOS) often negatively modulates myocardial function.
Xiong
Jiang-hui
JH
Institute of Space Medico-Engineering, Beijing, China. Xiongjh@life.com.cn
Li
Ying-hui
YH
Nie
Jie-lin
JL
Yu
Xiao-ying
XY
D000818:Animals; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000166:cytology / Q000201:enzymology; D009569:Nitric Oxide / Q000378:metabolism / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000378:metabolism*
D009569:Nitric Oxide; D019001:Nitric Oxide Synthase