Effects of Yoku-kan-san-ka-chimpi-hange on the sleep of normal healthy adult subjects.
Yoku-kan-san-ka-chimpi-hange (YKCH) is a drug used for insomnia in Japanese traditional herbal medicine. The present study evaluated the effects of YKCH on sleep by all-night polysomnography using the double-blind method. Yoku-kan-san-ka-chimpi-hange increased the total sleep time significantly, and tended to cause an increase in sleep efficiency and of stage 2 sleep, as well as a decrease of sleep latency and of stage 3 + 4 sleep. There was no apparent influence on rapid eye movement (REM) sleep. In terms of non-REM sleep, the effects of YKCH exhibit a profile similar to those of benzodiazepines.
Aizawa
Rika
R
Japanese Red Cross Junior College of Akita, Akita city, Japan. aizawa@venus.rcakita-jc.ac.jp
Kanbayashi
Takashi
T
Saito
Yasushi
Y
Ogawa
Yuriko
Y
Sugiyama
Tomonari
T
Kitajima
Tsuyoshi
T
Kaneko
Yoshihiko
Y
Abe
Masahito
M
Shimizu
Tetsuo
T
D000328:Adult; D001569:Benzodiazepines / Q000008:administration & dosage; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal; D006801:Humans; D008297:Male; D008518:Medicine, East Asian Traditional; D017286:Polysomnography / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects; D012894:Sleep Stages / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; C000607904:yokukansankachimpihange; D001569:Benzodiazepines