title: Comparison of wavefront-guided customized ablation vs. conventional ablation in laser in situ keratomileusis.
abstract: OBJECTIVE
  To compare visual outcome after applying wavefront-guided customized ablation with conventional ablation in laser in situ keratomileusis (LASIK) patients.
  
  
  METHODS
  We performed a prospective, randomized controlled study that included 22 eyes of 11 patients who were treated with LASIK using the Nidek EC-5000 excimer laser system. We applied wavefront-guided customized ablation (study group) in the first eye of each patient. The conventional ablation (control group) was performed in the other eye of the same patient. Best spectacle-corrected visual acuity (BSCVA), spherical equivalent refraction, and high-order aberrations were evaluated preoperatively and at 1 month. High-order aberrations were measured using the Nidek OPD-Scan.
  
  
  RESULTS
  Preoperative and 1-month postoperative BSCVA were better than 20/40 (100%) after LASIK with both conventional ablation (control) and wavefront-guided customized ablation. Preoperatively, mean high-order aberrations in the control group were 0.572 and in the study group, 0.428 (Zernike coefficient unit). One-month after LASIK, mean high-order aberrations in the control group were 0.496 and in the study group, 0.476 (Zernike coefficient unit). We found no statistically significant difference between preoperative and 1-month postoperative high-order aberrations in either group.
  
  
  CONCLUSIONS
  LASIK with both conventional ablation and wavefront-guided customized ablation resulted in the same BSCVA 1 month after LASIK. Preoperative and 1-month postoperative high-order aberrations were not statistically different following LASIK between ablation types.
authors.affiliation: Department of Ophthalmology, Ramathibodi Hospital School of Medicine, Bangkok, Thailand.
authors.forename: Anun
authors.initials: A
authors.lastname: Vongthongsri
authors.forename: Nutharin
authors.initials: N
authors.lastname: Phusitphoykai
authors.forename: Pichit
authors.initials: P
authors.lastname: Naripthapan
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000601:surgery*; D003315:Cornea / Q000601:surgery*; D005260:Female; D006801:Humans; D006956:Hyperopia / Q000601:surgery*; D020731:Keratomileusis, Laser In Situ / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery*; D011446:Prospective Studies; D012029:Refraction, Ocular; D014792:Visual Acuity