Expression of Golli proteins in adult human brain and multiple sclerosis lesions.
It has been suggested that Golli proteins, structurally related to myelin basic proteins (MBPs), have a role in autoimmune processes. We studied the expression of these proteins in multiple sclerosis (MS) and determined that the number of Golli-immunoreactive (ir) cells was significantly higher around lesions of chronic MS than in control white matter. Golli proteins were expressed in the adult oligodendrocyte precursor cells (OPCs), activated microglia/macrophages, and some demyelinated axons around MS lesions. Their expression in adult OPCs indicates remyelination attempts, whereas the expression in the subpopulation of microglia/macrophages suggests roles in the immune processes of MS. In addition, Golli proteins may be markers of axonal transection, which is characteristic for MS.
Filipovic
R
R
Department of Neuroscience, University of Connecticut Medical School, 263 Farmington Ave., Farmington, CT 06030-3401, USA.
Rakic
S
S
Zecevic
N
N
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000276:immunology / Q000473:pathology*; D001923:Brain Chemistry; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D008297:Male; D017628:Microglia / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins / Q000032:analysis* / Q000096:biosynthesis / Q000276:immunology; D009836:Oligodendroglia / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D013234:Stem Cells / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D014157:Transcription Factors / Q000032:analysis* / Q000096:biosynthesis / Q000276:immunology
C499048:MBP protein, human; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins; D014157:Transcription Factors