title: B cell development in gut associated lymphoid tissues.
abstract: B lymphocyte development can occur in a variety of anatomical sites. While typically considered to be a process that occurs in the bone marrow throughout life, it is becoming clear that gut associates sites of B cell development are critically important in many species of veterinary importance. Among these sites, the bursa of Fabricius in chickens and the ileal Peyer's patches of sheep are among the best studied. In these organs, it has become clear that many of the properties associated with B cell development in rodent and primate bone marrow do not apply. Thus while bone marrow B cell development typically involves an ongoing maturation of mature B cells from immature B lineage precursors that lack the expression of a surface immunoglobulin complex, gut associated lymphoid tissues (GALTs) may be colonized by a single wave of precursor cells during embryo development. Nonetheless, molecular analysis of the requirements for B lymphocyte development in GALTs reveals some striking parallels with requirements identified for B cell development in bone marrow. This article will discuss differences between B cell development in the bone marrow and GALTs and recent evidence emerging that yields insights into how these processes are regulated.
authors.affiliation: Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, Ont., Canada M5S 1A8. michael.ratcliffe@utoronto.ca
authors.forename: Michael J H
authors.initials: MJ
authors.lastname: Ratcliffe
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D001402:B-Lymphocytes / Q000502:physiology*; D051925:CD79 Antigens; D002645:Chickens / Q000276:immunology*; D006410:Hematopoiesis; D007422:Intestines / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000502:physiology
chemical_list: D015703:Antigens, CD; D051925:CD79 Antigens; D011947:Receptors, Antigen, B-Cell