title: Diffusion and perfusion MRI for the localisation of epileptogenic foci in drug-resistant epilepsy.
abstract: Drug-resistant epilepsy is an important clinical challenge, both diagnostically and therapeutically. More and more surgical options are being considered, but precise presurgical assessment is necessary. We prospectively studied eight patients with drug-resistant epilepsy, who underwent clinical examination, single photon emission computed tomography (SPECT) and interictal MRI, including diffusion- and perfusion-weighted echoplanar sequences. Lesions suspected on SPECT of being epileptogenic showed mild hypoperfusion, while the diffusion-weighted MRI (DWI) revealed increased apparent diffusion coefficients relative to the other side. However, these abnormalities were not visible on the corresponding maps. We showed that DWI and perfusion-weighted MRI could be used confirm the characteristics and site of an epileptogenic area in patients with drug-resistant epilepsy.
authors.affiliation: Department of Neuroradiology, Inselspital, Freiburgstrasse, 3010 Bern Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Heiniger
authors.forename: M
authors.initials: M
authors.lastname: el-Koussy
authors.forename: K
authors.initials: K
authors.lastname: Schindler
authors.forename: K O
authors.initials: KO
authors.lastname: Lövblad
authors.forename: C
authors.initials: C
authors.lastname: Kiefer
authors.forename: H
authors.initials: H
authors.lastname: Oswald
authors.forename: M
authors.initials: M
authors.lastname: Wissmeyer
authors.forename: L
authors.initials: L
authors.lastname: Mariani
authors.forename: F
authors.initials: F
authors.lastname: Donati
authors.forename: G
authors.initials: G
authors.lastname: Schroth
authors.forename: B
authors.initials: B
authors.lastname: Weder
mesh_terms: D000293:Adolescent; D000328:Adult; D004058:Diffusion; D004351:Drug Resistance / Q000502:physiology*; D004827:Epilepsy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D015899:Tomography, Emission-Computed, Single-Photon