The immunosuppressive effect of Fusarium mycotoxin as a function of HLA antigens.
We examined the blastogenic response to phytohaemaglutinin (PHA) in HLA-B8, DR3 positive and negative subjects in the presence or absence of the immunosuppressive Fusarium mycotoxin. HLA-B8, DR3 haplotype was associated with a depression of the response to mitogen in the absence of the mycotoxin, whereas in the presence of deoxynivalenol we could not detect significant differences among individuals either possessing or lacking this haplotype.
Berek
Lívia
L
Regional Blood Transfusion Center, Szeged, Hungary.
Petri
I B
IB
Mesterházy
A
A
Téren
J
J
D005670:Fusarium / Q000378:metabolism*; D006680:HLA Antigens / Q000235:genetics / Q000378:metabolism*; D015795:HLA-B8 Antigen / Q000235:genetics / Q000378:metabolism; D015803:HLA-DR3 Antigen / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation / Q000187:drug effects*; D009183:Mycotoxins / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology; D014255:Trichothecenes / Q000494:pharmacology*
D006680:HLA Antigens; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D009183:Mycotoxins; D010835:Phytohemagglutinins; D014255:Trichothecenes; C007262:deoxynivalenol