[Sensitizing and virus-neutralizing characteristics of goat immunoglobulins to Ebola virus].
Sensitizing and virus-neutralizing properties of IgG isolated from the sera of goats immunized with Ebola virus and a relevant gammaglobulin prepared by ethanol fractionation were compared. The ratio of the virus-neutralizing activities of subclasses IgG2, IgG1a, and IgG1b was 100:10:1. Anaphylactogenic activity of IgG2 in the immediate type hypersensitivity test in guinea pigs was 2-fold lower than that of IgG1a and IgG1b. Goat gammaglobulin to Ebola virus, consisting from IgG2 antibodies by more than 50%, possessed virus-neutralizing and sensitizing characteristics compatible to IgG2.
Zubavichene
N M
NM
Dedkova
L M
LM
Sergeev
N N
NN
Ofitserov
V I
VI
D000707:Anaphylaxis; D000818:Animals; D000914:Antibodies, Viral / Q000008:administration & dosage / Q000096:biosynthesis / Q000276:immunology*; D029043:Ebolavirus / Q000276:immunology*; D006041:Goats / Q000097:blood / Q000276:immunology*; D006168:Guinea Pigs; D007114:Immunization; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000096:biosynthesis / Q000276:immunology*; D009500:Neutralization Tests
D000914:Antibodies, Viral; D007074:Immunoglobulin G
Sensibiliziruiushchie i virusneĭtralizuiushchie svoĭstva koz'ikh immunoglobulinov protiv virusa Ebola.