Firing properties of neurones in the laterodorsal hypothalamic area during sleep and wakefulness.
In undrugged, head-restrained rats, neuronal activity was recorded in and around the laterodorsal hypothalamic area where orexin neurones are distributed. Among 22 neurones observed across whole sleep-waking states, half (n = 11) were most active during paradoxical sleep and least active during waking. Others were equally more active during paradoxical sleep and waking than during slow-wave sleep (n = 6), or were most active during waking and least active during paradoxical sleep (n = 3). The majority of neurones started to increase firing activity prior to the transition of sleep-waking states. These results suggest that the area of the hypothalamus containing orexin neurones plays a role in sleep-waking regulation.
Koyama
Yoshimasa
Y
Department of Physiology, Fukushima Medical University School of Medicine, Fukushima, Japan. koyamays@fmu.ac.jp
Kodama
Toru
T
Takahashi
Kazumi
K
Okai
Ken
K
Kayama
Yukihiko
Y
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004569:Electroencephalography; D007032:Hypothalamus, Anterior / Q000166:cytology / Q000502:physiology*; D007034:Hypothalamus, Posterior / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep; D014851:Wakefulness