title: Design and synthesis of biotin chain-terminated glycopolymers for surface glycoengineering.
abstract: Biotin chain-terminated glycopolymers were generated by cyanoxyl-mediated free-radical polymerization using a biotin-derivatized arylamine initiator with high conversion (75%) and low polydispersity (1.30). Streptavidin-biotinylated glycopolymer binding was verified by SDS-PAGE gel shift assay and patterned glycocalyx-mimetic surfaces successfully fabricated.
authors.affiliation: Laboratory for Biomolecular Materials Research, Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA. xsun@emory.edu
authors.forename: Xue-Long
authors.initials: XL
authors.lastname: Sun
authors.forename: Keith M
authors.initials: KM
authors.lastname: Faucher
authors.forename: Michelle
authors.initials: M
authors.lastname: Houston
authors.forename: Daniel
authors.initials: D
authors.lastname: Grande
authors.forename: Elliot L
authors.initials: EL
authors.lastname: Chaikof
mesh_terms: D001704:Biopolymers / Q000737:chemistry*; D001710:Biotin / Q000031:analogs & derivatives* / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D007785:Lactose / Q000737:chemistry; D037102:Lectins / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D019809:Streptavidin / Q000737:chemistry
chemical_list: D001704:Biopolymers; D006027:Glycosides; D037102:Lectins; D001710:Biotin; D019809:Streptavidin; D007785:Lactose