title: Triple valve replacement in a patient with severe carcinoid heart disease.
abstract: We report on the case of a 34-year-old male patient suffering from end-stage carcinoid heart disease with severe tricuspid, pulmonary and mitral valve regurgitation. In addition, a persisting foramen ovale was present. The primary carcinoid tumor was never discovered. However, urine 5-hydroxy-indole-acetic-acid (5-HIAA) were consistently elevated after the first diagnosis of carcinoid disease and after eight years of medication with Octreotide and Interferon alpha-2b our patient developed significant cardiac insufficiency mainly due to severe valvular dysfunction. Ultimately, mechanical tricuspid, mitral and pulmonary valve replacement was performed. Twelve hours following the operation the patient had to be returned to the operating room for persisting intrathoracic hemorrhage. He recovered uneventfully and was discharged from hospital on day 37. Twelve months following triple valve replacement the cardiac status recovered from preoperative NYHA-IV to NYHA-I.
authors.affiliation: Division of Thoracic and Cardiovascular Surgery, Hanover Medical School, Carl Neuberg Strasse 1, 30623, Hanover, Germany. wilhelmi@thg.mh-hannover.de
authors.forename: M
authors.initials: M
authors.lastname: Wilhelmi
authors.forename: M K H
authors.initials: MK
authors.lastname: Fritz
authors.forename: S
authors.initials: S
authors.lastname: Fischer
authors.forename: A
authors.initials: A
authors.lastname: Haverich
authors.forename: W
authors.initials: W
authors.lastname: Harringer
mesh_terms: D000328:Adult; D002275:Carcinoid Heart Disease / Q000150:complications / Q000601:surgery*; D006333:Heart Failure / Q000209:etiology; D006344:Heart Septal Defects, Atrial / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008297:Male; D008944:Mitral Valve Insufficiency / Q000601:surgery; D008946:Mitral Valve Stenosis / Q000601:surgery; D011665:Pulmonary Valve Insufficiency / Q000601:surgery; D011666:Pulmonary Valve Stenosis / Q000601:surgery; D013536:Suture Techniques; D016896:Treatment Outcome; D014262:Tricuspid Valve Insufficiency / Q000601:surgery