Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum.
The inhibitory effects of the dormant spores, the germinating spores, the sporoderm-broken germinating spores (SBGS), and the lipids extracted from the germinating spores of Ganoderma lucidum on the growth of mouse hepatoma, sarcoma S-180, and reticulocyte sarcoma L-II cells were investigated, respectively. The dormant spores could be activated by germination, and thus the bioactivities of the spores might be enhanced. The sporoderm-broken spores could show much higher bioactivities than the whole spores. Both the lipids extracted from the germinating spores and the SBGS of G. lucidum had remarkable antitumor effects in a dose-dependent manner, and could significantly inhibit three tumors with an inhibition of 80-90%.
Liu
Xin
X
Food Engineering Research Center of State Education Ministry, Zhongshan University, Guangzhou 510275, People's Republic of China.
Yuan
Jian-Ping
JP
Chung
Chee-Keung
CK
Chen
Xiao-Jun
XJ
D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents; D004195:Disease Models, Animal; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D008516:Medicine, Chinese Traditional; D051379:Mice; D020940:Reishi / Q000502:physiology*; D012510:Sarcoma 180 / Q000188:drug therapy*; D012513:Sarcoma, Experimental / Q000188:drug therapy*; D013172:Spores, Fungal / Q000737:chemistry
D000970:Antineoplastic Agents