title: Frequent blood-brain barrier disruption in the human cerebral cortex.
abstract: 1. The blood-brain barrier (BBB) protects the brain from circulating xenobiotic agents. The pathophysiology, time span, spatial pattern, and pathophysiological consequences of BBB disruptions are not known. 2. Here, we report the quantification of BBB disruption by measuring enhancement levels in computerized tomography brain images. 3. Pathological diffuse enhancement associated with elevated albumin levels in the cerebrospinal fluid (CSF) was observed in the cerebral cortex of 28 out of 43 patients, but not in controls. Four patients displayed weeks-long focal BBB impairment. In 19 other patients, BBB disruption was significantly associated with elevated blood pressure, body temperature, serum cortisol, and stress-associated CSF 'readthrough" acetylcholinesterase. Multielectrode electroencephalography revealed enhanced slow-wave activities in areas of focal BBB disruption. Thus, quantification of BBB disruption using minimally invasive procedures, demonstrated correlations with molecular, clinical, and physiological stress-associated indices. 4. These sequelae accompany a wide range of neurological disorders, suggesting that persistent, detrimental BBB disruption is considerably more frequent than previously assumed.
authors.affiliation: Department of Physiology and Neurosurgery, Soroka University Hospital, Zlotowski Center of Neuroscience, Ben-Gurion University, Beersheva, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Tomkins
authors.forename: D
authors.initials: D
authors.lastname: Kaufer
authors.forename: A
authors.initials: A
authors.lastname: Korn
authors.forename: I
authors.initials: I
authors.lastname: Shelef
authors.forename: H
authors.initials: H
authors.lastname: Golan
authors.forename: E
authors.initials: E
authors.lastname: Reichenthal
authors.forename: H
authors.initials: H
authors.lastname: Soreq
authors.forename: A
authors.initials: A
authors.lastname: Friedman
mesh_terms: D000110:Acetylcholinesterase / Q000134:cerebrospinal fluid; D000328:Adult; D000368:Aged; D000418:Albumins / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier / Q000276:immunology*; D001927:Brain Diseases / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D002648:Child; D015331:Cohort Studies; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013312:Stress, Physiological / Q000473:pathology / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed
chemical_list: D000418:Albumins; D000110:Acetylcholinesterase