title: Synthesis and antimicrobial activity of hydroxyalkyl- and hydroxyacyl-phenols and their benzyl ethers.
abstract: New phenolic compounds with hydrophilic side chains were prepared from 4-benzyloxybenzaldehyde and alkenyl magnesium bromides, followed by Sharpless dihydroxylation and hydrogenolytic removal of the benzyl group. The resulting compounds were tested in an agar diffusion assay against gram positive bacteria, gram negative bacteria, and against the fungi Candida glabrata and Aspergillus niger.
authors.affiliation: Department of Pharmacy, Ludwig Maximilians University, Butenandt Strasse 5-13, 81377 Munich, Germany. hjkra@cup.uni-muenchen.de
authors.forename: J
authors.initials: J
authors.lastname: Krauss
authors.forename: D
authors.initials: D
authors.lastname: Unterreitmeier
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D010647:Phenyl Ethers / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D007202:Indicators and Reagents; D010647:Phenyl Ethers