Downstream targets of let-60 Ras in Caenorhabditis elegans.
In Caenorhabditis elegans, let-60 Ras controls many cellular processes, such as differentiation of vulval epithelial cells, function of chemosensory neurons, and meiotic progression in the germ line. Although much is known about the let-60 Ras signaling pathway, relatively little is understood about the target genes induced by let-60 Ras signaling that carry out terminal effector functions leading to morphological change. We have used DNA microarrays to identify 708 genes that change expression in response to activated let-60 Ras.
Romagnolo
Béatrice
B
Department of Developmental Biology and Genetics, Stanford University Medical School, California 94305, USA.
Jiang
Min
M
Kiraly
Moni
M
Breton
Carrie
C
Begley
Rebecca
R
Wang
John
J
Lund
James
J
Kim
Stuart K
SK
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins; D018507:Gene Expression Regulation, Developmental; D015801:Helminth Proteins / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D015398:Signal Transduction / Q000235:genetics; D018631:ras Proteins / Q000235:genetics*
D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; C066646:let-60 protein, C elegans; D018631:ras Proteins