title: Squamous carcinoma of the external auditory canal: a different approach.
abstract: Squamous carcinoma of the external ear canal is a rare disease and a challenge to treat. Some controversy exists regarding the best options for treatment. Reported 5-year survival varies between 35% and 63%. Since 1976, we have adopted a conservative approach to these tumours, with patients undergoing a specific protocol of meticulous tumour debulking followed by a course of repeated topical 5-fluoro-uracil (5-FU) cream application and necrotectomy. Data was collected prospectively. From 1976 to 1998, 23 patients underwent primary treatment according to our protocol. Nine patients had T1 disease whereas six had T2 and eight had T3 disease. The 5- and 10-year overall survivals were 74% and 60% respectively. These results compare very favourably with those in the literature and surgical debulking with topical 5-FU and necrotectomy remains our primary treatment of choice for squamous cell carcinoma of the external auditory canal.
authors.affiliation: The Department of Otolaryngology and Head and Neck Surgery, University Hospital Rotterdam, The Netherlands. knegt@knod.azr.nl
authors.forename: P P
authors.initials: PP
authors.lastname: Knegt
authors.forename: K W
authors.initials: KW
authors.lastname: Ah-See
authors.forename: C A
authors.initials: CA
authors.lastname: Meeuwis
authors.forename: L A
authors.initials: LA
authors.lastname: van der Velden
authors.forename: J D F
authors.initials: JD
authors.lastname: Kerrebijn
authors.forename: M F
authors.initials: MF
authors.lastname: De Boer
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D004424:Ear Canal; D004428:Ear Neoplasms / Q000401:mortality / Q000628:therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D005472:Fluorouracil