title: Synthesis of cyclosporin A-derived affinity reagents by olefin metathesis.
abstract: [reaction: see text] New affinity reagents were synthesized using alkene metathesis to directly modify the MeBmt side chain of cyclosporin A. The reagents were used to detect novel cyclophilins from cellular extracts.
authors.affiliation: Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Smulik
authors.forename: Steven T
authors.initials: ST
authors.lastname: Diver
authors.forename: Fan
authors.initials: F
authors.lastname: Pan
authors.forename: Jun O
authors.initials: JO
authors.lastname: Liu
mesh_terms: D000345:Affinity Labels / Q000138:chemical synthesis*; D000475:Alkenes / Q000737:chemistry*; D016572:Cyclosporine / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D007166:Immunosuppressive Agents / Q000737:chemistry*
chemical_list: D000345:Affinity Labels; D000475:Alkenes; D007166:Immunosuppressive Agents; D016572:Cyclosporine