title: Acute vasculitis after endovascular brachytherapy.
abstract: OBJECTIVE
  Angioplasty effectively relieves coronary artery stenosis but is often followed by restenosis. Endovascular radiation (beta or gamma) at the time of angioplasty prevents restenosis in a large proportion of vessels in swine (short term) and humans (short and long term). Little information is available about the effects of this radiation exposure beyond the wall of the coronary arteries.
  
  
  METHODS
  Samples were obtained from 76 minipigs in the course of several experiments designed to evaluate endovascular brachytherapy: 76 of 114 coronary arteries and 6 of 12 iliac arteries were exposed to endovascular radiation from 32P sources (35 Gy at 0.5 mm from the intima). Two-thirds of the vessels had angioplasty or stenting. The vessels were systematically examined either at 28 days or at 6 months after radiation.
  
  
  RESULTS
  We found an unexpected lesion: acute necrotizing vasculitis in arterioles located < or =2.05 mm from the target artery. It was characterized by fibrinoid necrosis of the wall, often associated with lymphocytic exudates or thrombosis. Based on the review of perpendicular sections of tissue samples, the arterioles had received between 6 and 40 Gy. This arteriolar vasculitis occurred at 28 days in samples from 51% of irradiated coronary arteries and 100% of irradiated iliac arteries. By 6 months, the incidence of acute vasculitis decreased to 24% around the coronary arteries. However, at that time, healing vasculitis was evident, often with luminal narrowing, in 46% of samples. Vasculitis was not seen in any of 44 samples from unirradiated vessels (0%) and had no relation to angioplasty, stenting, or their sequelae. This radiation-associated vasculitis in the swine resembles the localized lymphocytic vasculitis that we have reported in tissues of humans exposed to external radiation. On the other hand, it is quite different from the various types of systemic vasculitis that occur in nonirradiated humans.
  
  
  CONCLUSIONS
  Endoarterial brachytherapy using 32P results in vascular effects beyond the adventitia of the target vessel. This necrotizing vasculitis is causally related to radiation, but its mechanism is unclear and a dose effect is not evident. Quite possibly, local upregulation of inflammatory cytokines contributes to this radiation-associated vasculitis, which only involved some of the arterioles in each sample. It is likely that radiation-associated vasculitis also occurs around human coronary arteries and may result in foci of ischemia. To our knowledge, this lesion has not been previously recognized, either in experimental models or in human specimens examined after angioplasty/brachytherapy.
authors.affiliation: Pathology and Laboratory Medicine Service (113), Stanford University and Veterans Affairs Medical Center, 3801 Miranda Avenue, Palo Alto, CA 94304, USA.
authors.forename: Luis F
authors.initials: LF
authors.lastname: Fajardo L-G
authors.forename: Stavros D
authors.initials: SD
authors.lastname: Prionas
authors.forename: Grzegorz L
authors.initials: GL
authors.lastname: Kaluza
authors.forename: Albert E
authors.initials: AE
authors.lastname: Raizner
mesh_terms: D000208:Acute Disease; D000800:Angioplasty, Balloon / Q000009:adverse effects; D000818:Animals; D001160:Arterioles / Q000473:pathology / Q000528:radiation effects*; D001167:Arteritis / Q000209:etiology* / Q000473:pathology; D001918:Brachytherapy / Q000009:adverse effects*; D003327:Coronary Disease / Q000209:etiology* / Q000473:pathology; D005260:Female; D008297:Male; D011833:Radiation Injuries, Experimental / Q000150:complications* / Q000473:pathology; D015607:Stents; D013552:Swine; D013556:Swine, Miniature