title: PTHrP-producing tumor: squamous cell carcinoma of the liver accompanied by humoral hypercalcemia of malignancy, increased IL-6 and leukocytosis.
abstract: A 77-year-old man was admitted to our hospital showing symptoms of general fatigue and appetite loss. He had leukocytosis, thrombocytosis and hypercalcemia with elevated serum levels of parathyroid hormone related peptide (PTHrP) and interleukin-6 (IL-6). An increase in tumor markers SCC and CYFURA21-1 was observed. The liver contained a huge tumor, which was proved to be PTHrP producing squamous cell carcinoma by immuno-histochemical analysis. Since the tumor did not express IL-6, it was assumed to be induced by PTHrP in osteoblasts. This is the first report of PTHrP producing squamous cell carcinoma of the liver.
authors.affiliation: Department of Internal Medicine, Aizenbashi Hospital, Osaka.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Asanuma
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hagiwara
authors.forename: Ikuko
authors.initials: I
authors.lastname: Matsumoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Matsuda
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Nakamura
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Kouhara
authors.forename: Makoto
authors.initials: M
authors.lastname: Miyamoto
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miyashita
authors.forename: Sanai
authors.initials: S
authors.lastname: Noguchi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Morimoto
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D002118:Calcium / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006934:Hypercalcemia / Q000097:blood*; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000097:blood; D007964:Leukocytosis / Q000097:blood; D008113:Liver Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D044162:Parathyroid Hormone-Related Protein; D036361:Peptide Hormones / Q000097:blood*; D011859:Radiography; D013922:Thrombocytosis / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D015850:Interleukin-6; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D036361:Peptide Hormones; D002118:Calcium