title: The antiandrogenic effect of flutamide improves uterine perfusion in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate whether, by blocking androgen action, flutamide can decrease and normalize vascular resistance in the uterine artery in patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Prospective and controlled study.
  
  
  METHODS
  Endocrinological Centre of the Department of Obstetrics and Gynecology of the University of Cagliari, Italy.
  
  
  METHODS
  Twenty-two patients with PCOS were enrolled in the study and randomly assigned to one of the following two treatments for 3 months: oral administration of flutamide (250 mg twice daily) or placebo.
  
  
  METHODS
  Doppler flow measurement of the uterine artery and serum hormone concentration determination during the early follicular phase of the menstrual cycle before treatment and during the third month of treatment.
  
  
  METHODS
  Pulsatility index (PI) of the uterine artery before and during treatment.
  
  
  RESULTS
  The PI of the uterine artery decreased significantly during treatment. No difference was found in patients treated with placebo. Correlation was found only between the PI values of the uterine artery and DHEAS.
  
  
  CONCLUSIONS
  The low uterine perfusion that characterizes patients with PCOS can be improved by the antiandrogenic effect of flutamide.
authors.affiliation: Department of Obstetrics and Gynecology of the University of Cagliari, Cagliari, Italy. gineca.sajossa@tiscal.it
authors.forename: Silvia
authors.initials: S
authors.lastname: Ajossa
authors.forename: Stefano
authors.initials: S
authors.lastname: Guerriero
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Paoletti
authors.forename: Marisa
authors.initials: M
authors.lastname: Orrù
authors.forename: Gian Benedetto
authors.initials: GB
authors.lastname: Melis
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000726:Androgen Antagonists / Q000627:therapeutic use*; D001158:Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D005485:Flutamide / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D010919:Placebos; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000503:physiopathology*; D011674:Pulse; D012039:Regional Blood Flow / Q000187:drug effects; D014463:Ultrasonography; D014599:Uterus / Q000098:blood supply*
chemical_list: D000726:Androgen Antagonists; D010919:Placebos; D019314:Dehydroepiandrosterone Sulfate; D005485:Flutamide