Studies on the biosynthesis of striatal-type diterpenoids and the biological activity of herical.
Feeding experiments with specifically 13C-labeled glucose disclosed that the diterpenoid part of the striatals/striatins is formed via the mevalonate pathway, whereas the pentose moiety originates either via glucuronic acid (70%) or the pentose phosphate cycle (30%). Application of radioactively labeled herical to cultures of Hericium ramosum demonstrates the pivotal role of this cyathane-xyloside in striatal biosynthesis. Herical inhibits a large spectrum of fungi and bacteria and shows cytotoxic and hemolytic properties.
Anke
Timm
T
LB Biotechnologie der Universität, Kaiserslautern, Germany. anke@rhrk.uni-kl.de
Rabe
Udo
U
Schu
Peter
P
Eizenhöfer
Thomas
T
Schrage
Monika
M
Steglich
Wolfgang
W
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001487:Basidiomycota / Q000737:chemistry* / Q000378:metabolism; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D014532:Uridine Diphosphate Glucose / Q000378:metabolism
D000900:Anti-Bacterial Agents; D004224:Diterpenes; C459781:herical; D014532:Uridine Diphosphate Glucose