[Regulation of smooth muscles of the vascular wall in the rabbit pulmonary artery].
The cholinergic, histaminergic and adrenergic features of regulation of the small muscles contractile activity in a vascular wall of a pulmonary artery in rabbits and involvement of an endothelium in these processes, were investigated. The cholinergic release phenomenon of small muscles of the rabbit pulmonary artery has a two-component character of dose dependence. The low-threshold components of Pilocarpinum relaxing effect has an endothelium-dependent nature. The important feature of histaminergic regulation of contractile activity of segments involves a direct contractile effect of histamine that is not inherent. The endothelium renders a suppressing effect on histaminergic contraction of small muscles of the rabbit pulmonary artery. A basic feature of adrenergic regulation of the pulmonary artery involves registered-beta-adrenergic contractile effects in small muscles of a vascular wall. The activation of the cAMP-dependent signal system in small muscles of a pulmonary artery is capable of rendering a contractile effect. The detected features of a regulation in the small circle can have an essential clinical-physiological value.
Kapilevich
L V
LV
Siberian Medical University, 2 Moskovsky Trakt, Tomsk 634050, Russia.
Nosarev
A V
AV
D'akova
E Iu
EIu
Kovalev
I V
IV
Baskakov
M B
MB
Anfinogenova
Ia D
IaD
Frolov
V N
VN
Medvedev
M A
MA
D000322:Adrenergic Agonists / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D006632:Histamine / Q000494:pharmacology; D017442:Histamine Agonists / Q000494:pharmacology; D066298:In Vitro Techniques; D018721:Muscarinic Agonists / Q000494:pharmacology; D009119:Muscle Contraction; D009126:Muscle Relaxation; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D020030:Nitric Oxide Donors / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D009599:Nitroprusside / Q000494:pharmacology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits
D000322:Adrenergic Agonists; D017442:Histamine Agonists; D018721:Muscarinic Agonists; D020030:Nitric Oxide Donors; D010726:Phosphodiesterase Inhibitors; D010862:Pilocarpine; D009599:Nitroprusside; D006632:Histamine; D000242:Cyclic AMP; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester
Osobennosti reguliatsii gladkikh myshts sosudistoĭ stenki legochnoĭ arterii krolika.