S-propyl cysteine reduces the secretion of apolipoprotein B100 and triacylglycerol by HepG2 cells.
A number of sulfur-containing amino acids and peptides are found in allium plants such as onion and garlic that have physiologic functions. In HepG2 cells, S-propyl cysteine decreased the secretion of apolipoprotein B100. The compound reduced the secretion of newly synthesized triacylglycerol and cholesterols from radiolabeled acetate. We associated the decrease of apolipoprotein B100 secretion to the length of the acyl-chain of the sulfur-containing amino acids. The present study suggests that foods containing S-propyl cysteine including onions have beneficial effects.
Han
Seo-young
SY
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, Saga 840-8502, Japan
Hu
Ying
Y
Anno
Takahiko
T
Yanagita
Teruyoshi
T
D000490:Allium / Q000737:chemistry*; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D003470:Culture Media; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D010936:Plant Extracts / Q000494:pharmacology; D014280:Triglycerides / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D003470:Culture Media; D010936:Plant Extracts; D014280:Triglycerides; C028742:S-propylcysteine; D002784:Cholesterol; D003545:Cysteine