title: Hemodynamic state and the role of angiotensin II in ovarian hyperstimulation syndrome in the rabbit.
abstract: OBJECTIVE
  To investigate the hemodynamic state in the ovarian hyperstimulation syndrome (OHSS) in the rabbit model and to determine the role of angiotensin II in the pathophysiology of this syndrome.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  Physiology laboratory.
  
  
  METHODS
  Female New Zealand rabbits were studied; 16 rabbits were stimulated with gonadotropins, and 6 were controls. Six of the stimulated rabbits received additional treatment with captopril.
  
  
  METHODS
  Cardiac index, blood pressure, and heart rate were recorded.
  
  
  RESULTS
  Gonadotropin-stimulated rabbits had significant enlargement of ovaries that was not modified by captopril. Ascites was present in 80% of animals in the OHSS group; captopril significantly decreased the incidence and volume of ascites. The three groups did not differ in blood pressure, heart rate, cardiac index, and total peripheral resistance.
  
  
  CONCLUSIONS
  In rabbits with OHSS, ascites are a primary event. Such animals are normotensive and have normal vascular resistance and cardiac index. Angiotensin-converting enzyme inhibition decreases the incidence of OHSS in the rabbit model by 30%, suggesting that angiotensin II may play a role in the formation of ascites.
authors.affiliation: Departmento de Fisiología de la Universidad de Murcia, Murcia, Spain.
authors.forename: Maria Jose G
authors.initials: MJ
authors.lastname: Teruel
authors.forename: Luis F
authors.initials: LF
authors.lastname: Carbonell
authors.forename: Maria Carmen
authors.initials: MC
authors.lastname: Llanos
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Parrilla
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Abad
authors.forename: Isabel
authors.initials: I
authors.lastname: Hernandez
mesh_terms: D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001201:Ascites / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D008596:Menotropins / Q000494:pharmacology; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced / Q000503:physiopathology*; D010053:Ovary / Q000187:drug effects / Q000473:pathology; D011817:Rabbits
chemical_list: D006063:Chorionic Gonadotropin; D000804:Angiotensin II; D008596:Menotropins