Antenatal and intrapartum antecedents of cerebral palsy: a case-control study.
OBJECTIVE
To identify antenatal and intrapartum factors contributing to the aetiology of cerebral palsy (CP).


METHODS
A case-control study using moderate/severe cases of cerebral palsy identified from the Victorian Cerebral Palsy Register and two controls per case identified through the Victorian Perinatal Data Collection Unit.


RESULTS
A number of previously identified risk factors for CP were confirmed in our data. New observations were (in specific sub-groups): protective effects of mother's negative Rhesus status, cigarette smoking at the first visit and episiotomy and an increased risk of CP associated with an abnormal antenatal cardiotocograph.


CONCLUSIONS
Although the result of the deliberate investigation of specific aspects of the antenatal and intrapartum period identified from a pilot study, our new findings must be interpreted with caution as they were not all based on specific a priori hypotheses, although some had been examined by other investigators. We would encourage their evaluation in other data sets.
Walstab
Janet
J
Department of Child Development and Rehabilitation, Royal Childre's Hospital and Murdoch Children's Research Institute, Parkville, Australia.
Bell
Robin
R
Reddihough
Dinah
D
Brennecke
Shaun
S
Bessell
Christine
C
Beischer
Norman
N
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000453:epidemiology* / Q000209:etiology*; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D016015:Logistic Models; D008423:Maternal Age; D008875:Middle Aged; D007744:Obstetric Labor Complications; D010865:Pilot Projects; D011247:Pregnancy; D011248:Pregnancy Complications; D011272:Pregnancy, Multiple; D011295:Prenatal Care; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014739:Victoria / Q000453:epidemiology