A new neuroprotective pinusolide derivative from the leaves of Biota orientalis.
A new pinusolide derivative, 15-methoxypinusolidic acid (1), and another new isopimarane diterpene, ent-isopimara-15-en-3 alpha,8 alpha-diol (2) with three known diterpenes, lambertianic acid (3), isopimara-8(9),15-dien-18-oic acid (4) and isopimara-7(8),15-dien-3 beta,18-diol (5) were isolated from the 90% MeOH fraction of Biota orientalis (L.) ENDL. (Cupressaceae) leaves. Chemical structures of 1-5 were elucidated by analyses of their spectral data, including the two-dimensional (2D) NMR technique. Compound 1 showed significant protective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells.
Koo
Kyung Ah
KA
College of Pharmacy, Seoul National University, Korea.
Sung
Sang Hyun
SH
Kim
Young Choong
YC
D044822:Biodiversity; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D029783:Thuja
C464724:15-methoxypinusolidic acid; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; C101973:pinusolide