title: Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae).
abstract: Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20alpha-hydroxy-tingenone showed high activity, epikatonic acid was less active, while populnilic and populninic acids were inactive against the trypanosome of the subgenus Schizotrypanum tested. Benzonidazole, nifurtimox, ketoconazole and primaquine presented a remarkable dose-dependent inhibitory effect reaching practically to a total growth inhibition of the parasite at the end of incubation time. The trypanosome tested appear to be a suitable model for preliminary screen for anti T. (S.) cruzi compounds.
authors.affiliation: Núcleo de Estudo de Plantas Medicinais, Departamento de Química, UFMG, MG, Brasil.
authors.forename: Lucienir Pains
authors.initials: LP
authors.lastname: Duarte
authors.forename: Sidney Augusto
authors.initials: SA
authors.lastname: Vieira Filho
authors.forename: Grácia Divina de Fátima
authors.initials: GD
authors.lastname: Silva
authors.forename: José Rego
authors.initials: JR
authors.lastname: de Sousa
authors.forename: Artur da Silveira
authors.initials: Ada S
authors.lastname: Pinto
mesh_terms: D000818:Animals; D029753:Celastraceae / Q000737:chemistry*; D021261:Parasitic Sensitivity Tests; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D014315:Triterpenes; D014344:Trypanocidal Agents