title: Diagnosis and treatment of Paget's disease of bone.
abstract: Paget's disease of bone (also known as osteitis deformans) is a nonmalignant disease involving accelerated bone resorption followed by deposition of dense, chaotic, and ineffectively mineralized bone matrix. The origin of the disease is unknown, and it is frequently asymptomatic; however, the patient may present with symptoms depending on the bones involved. The most common symptom is pain in the affected bone; neurologic, hearing, vision, cardiac, and oncologic complications are possible. Diagnosis is primarily made by radiographs. Bisphosphonates are the most common treatment.
authors.affiliation: Department of Internal Medicine and the Muller Center for Senior Health, Abington Memorial Hospital, Pennsylvania 19001-3788, USA.
authors.forename: Doron
authors.initials: D
authors.lastname: Schneider
authors.forename: Mary T
authors.initials: MT
authors.lastname: Hofmann
authors.forename: Jeannette A
authors.initials: JA
authors.lastname: Peterson
mesh_terms: D002116:Calcitonin / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D010001:Osteitis Deformans / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
chemical_list: D004164:Diphosphonates; D002116:Calcitonin