Concordance as well as discordance for congenital malformations in valproate-exposed half-siblings with parental consanguinity may indicate a specific gene-teratogen interaction.
The possibility of gene-teratogen interaction is suggested in a family formerly reported by Gardner et al. [(2001) Clin Dysmorphol 10:203-208] in which both concordance and discordance exist for congenital malformations in equally valproate-exposed siblings.
ten Berg
K
K
Lindhout
D
D
D000927:Anticonvulsants / Q000009:adverse effects*; D003241:Consanguinity; D006801:Humans; D013723:Teratogens / Q000633:toxicity*; D014635:Valproic Acid / Q000009:adverse effects*
D000927:Anticonvulsants; D013723:Teratogens; D014635:Valproic Acid