title: Gastric-type adenocarcinoma of the duodenal second portion histogenetically associated with hyperplasia and gastric-foveolar metaplasia of Brunner's glands.
abstract: We report a case of a pedunculated polyp with a focus of gastric-type adenocarcinoma arising in the opposite side of the papilla Vater of the duodenal second portion. The carcinoma was surrounded by lobules of hyperplastic Brunner's glands. Immunohistochemically the carcinoma tissue showed both gastric foveolar-type mucin ( MUC5AC) and pyloric/Brunner's gland-type mucin ( MUC6), in which proliferating cells positive for MIB-1 (Ki-67) were scattered diffusely. Most of the hyperplastic Brunner's glands were positive for MUC6, while cells toward the lumen in the superficial layer were positive for MUC5AC and MIB-1. This directional pattern of differentiation of Brunner's glands has recently been demonstrated by our group in the histogenetic course of gastric metaplasia originating directly from Brunner's glands. Therefore the present carcinoma is thought to have developed under induction of gastric-foveolar differentiation in a manner very similar to that of gastric metaplasia in hyperplastic Brunner's glands.
authors.affiliation: Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga 520-2192 Japan. kushima@belle.shiga-med.ac.jp
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kushima
authors.forename: Manfred
authors.initials: M
authors.lastname: Stolte
authors.forename: Klaus
authors.initials: K
authors.lastname: Dirks
authors.forename: Michael
authors.initials: M
authors.lastname: Vieth
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Okabe
authors.forename: Franz
authors.initials: F
authors.lastname: Borchard
authors.forename: Takanori
authors.initials: T
authors.lastname: Hattori
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D002011:Brunner Glands / Q000473:pathology*; D004379:Duodenal Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007413:Intestinal Mucosa / Q000473:pathology; D007417:Intestinal Polyps / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D055271:Mucin 5AC; D055272:Mucin-6; D009077:Mucins / Q000378:metabolism
chemical_list: C524678:MUC5AC protein, human; C524734:MUC6 protein, human; D055271:Mucin 5AC; D055272:Mucin-6; D009077:Mucins