title: Seroprevalence of Helicobacter pylori in children with type 1 diabetes mellitus in Sardinia.
abstract: A few studies have reported an increased prevalence of Helicobacterpylori (HP) infection in diabetic subjects, which may be one of the causes of gastrointestinal symptoms and chronic atrophic gastritis frequently seen in diabetes of long duration. We determined the prevalence of HP infection in children and adolescents with Type 1 diabetes mellitus (T1DM) in the area of Sassari (northern Sardinia, Italy), which is characterized by an ethnically homogenous population at high risk of T1DM. HP IgG and IgA titres were measured in 138 patients with T1DM and 138 age-matched healthy controls. The percentage of infected subjects did not differ between T1DM patients (29.7%) and controls (32.6%). Globally, infected subjects were more than 1 yr older (13.0 +/- 2.7 yr) than non-infected ones (11.8 +/- 2.9 yr), independently of the presence of T1DM; in most HP-positive subjects infection was asymptomatic, and only 2 subjects in each group reported clinically relevant symptoms. HP-positive and HP-negative diabetic patients had the same duration of the disease (5.6 +/- 3.5 vs 5.5 +/- 3.6 yr) and received very similar doses of insulin (0.94 +/- 0.27 vs 0.96 +/- 0.4 IU/kg/d), whereas mean HbA1c was significantly lower in HP-positive patients (7.8 +/- 1.6% vs 8.6 +/- 1.7%,p=0.02). We conclude that the prevalence of HP infection is not higher in Sardinian children with T1DM as compared to controls of similar age, and the overall clinical impact of HP infection in terms of gastrointestinal symptoms and diabetic control seems to be low.
authors.affiliation: Department of Paediatrics and Neonatology, University of Sassari, Italy. carla.colombo@unimi.it
authors.forename: C
authors.initials: C
authors.lastname: Colombo
authors.forename: P A
authors.initials: PA
authors.lastname: Tomasi
authors.forename: G F
authors.initials: GF
authors.lastname: Meloni
authors.forename: A M
authors.initials: AM
authors.lastname: Marinaro
authors.forename: A
authors.initials: A
authors.lastname: Ogana
authors.forename: T
authors.initials: T
authors.lastname: Meloni
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D005757:Gastritis, Atrophic / Q000453:epidemiology; D006442:Glycated Hemoglobin; D016481:Helicobacter Infections / Q000175:diagnosis / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007558:Italy / Q000453:epidemiology; D008297:Male; D016036:Seroepidemiologic Studies
chemical_list: D000907:Antibodies, Bacterial; D006442:Glycated Hemoglobin; D007070:Immunoglobulin A; D007074:Immunoglobulin G