Comparison of vasoconstrictor responses to selected NSAIDs in rabbit renal and femoral arteries.
BACKGROUND
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to induce adverse renal effects, which are closely related to physiological inhibition of renal prostaglandin synthesis.


OBJECTIVE
This study was aimed to evaluate the effect of drugs inhibiting both cyclooxygenase (COX) isoforms COX-1 and COX-2 on vasoconstrictor responses to noradrenaline in the rabbit renal artery and to compare these responses with femoral artery as a systemic vessel.


METHODS
Rabbit femoral and renal arteries were perfused with a constant flow. Vascular responses to drugs were measured and registered as changes in perfusion pressure.


RESULTS
It was found that the vasoconstrictor responses to noradrenaline were significantly enhanced after administration of all NSAIDs in both the renal and femoral arteries. The effect of indomethacin on renal vasoconstrictor responses was more pronounced compared to ibuprofen or phenacetin. Comparison of NSAIDs effects on renal and femoral arteries did not show significant differences.


CONCLUSIONS
These results demonstrate an increase of vasoconstrictor activity after NSAIDs administration without significant differences between the renal and femoral arteries. The strongest potentiation of the vasoconstrictor responses in the renal artery was found with indomethacin. (Tab. 1, Fig. 4, Ref. 20.)
Kristova
V
V
Department of Pharmacology, Faculty of Medicine, Comenius University, Sasinkova 4, SK-813 72 Bratislava A, Slovakia.
Djibril
N M
NM
Fackovcova
D
D
Kriska
M
M
Kurtansky
A
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D005263:Femoral Artery / Q000187:drug effects* / Q000502:physiology; D007052:Ibuprofen / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D010615:Phenacetin / Q000494:pharmacology; D011817:Rabbits; D012077:Renal Artery / Q000187:drug effects* / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D010615:Phenacetin; D007052:Ibuprofen; D007213:Indomethacin