title: Clinical trials in healthy volunteers with the new purified chick embryo cell rabies vaccine for man.
abstract: Behringwerke has developed the new, safe and economical purified chick embryo cell (PCEC) rabies vaccine. Due to the purification by zonal centrifugation the compatibility of this vaccine is excellent. Among 933 vaccinations in 219 healthy volunteers the only side-effect was mild pain at the injection-site in 17 vaccinations (1.7 per cent). The sero-conversion of PCEC rabies vaccine was 100 per cent in the tested healthy volunteers. The kinetics of antibody induction after PCEC rabies vaccine is comparable to antibody induction after HDC rabies vaccine. PCEC rabies vaccine induces cellular immunity as measured in lymphocyte transformation test, but no interferon activity.
authors.affiliation: Behring Werke AG, Marburg, West Germany.
authors.forename: U
authors.initials: U
authors.lastname: Bijok
authors.forename: R
authors.initials: R
authors.lastname: Barth
authors.forename: H
authors.initials: H
authors.lastname: Gruschkau
authors.forename: I
authors.initials: I
authors.lastname: Vodopija
authors.forename: S
authors.initials: S
authors.lastname: Smerdel
authors.forename: H
authors.initials: H
authors.lastname: Kukla
authors.forename: R
authors.initials: R
authors.lastname: Geursen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000276:immunology*; D005260:Female; D006262:Health; D006801:Humans; D007117:Immunization, Secondary; D007372:Interferons / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011818:Rabies / Q000276:immunology* / Q000517:prevention & control; D011819:Rabies Vaccines / Q000009:adverse effects* / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines; D007372:Interferons