Corticotropin-releasing hormone-related peptides and receptors: emergent regulators of cardiovascular adaptations to stress.
Since its discovery 2 decades ago, potent effects of corticotropin-releasing hormone (CRH) on the heart and vasculature have been consistently observed. The recent discoveries of novel CRH-related peptides residing in the heart and a distinct cardiac CRH receptor (CRH-R2), have renewed interest in the role of the CRH family on cardiovascular function. This review highlights the emerging view of a peripheral, cardiac CRH system and its potential relevance in mediating the adaptive response of the heart to stress.
Coste
Sarah C
SC
Oregon Health and Science University, Department of Molecular Microbiology and Immunology, Portland 97201, USA.
Quintos
Robert F
RF
Stenzel-Poore
Mary P
MP
D000595:Amino Acid Sequence; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology*; D002352:Carrier Proteins / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D018019:Receptors, Corticotropin-Releasing Hormone / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D013315:Stress, Psychological / Q000503:physiopathology*; D054832:Urocortins
C101531:CRF receptor type 2; D002352:Carrier Proteins; D018019:Receptors, Corticotropin-Releasing Hormone; D054832:Urocortins; D003346:Corticotropin-Releasing Hormone