Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period.
In a previous report, we were unable to entrain one out of seven totally blind people with free-running endogenous melatonin rhythms to 10 mg of exogenous melatonin. This person had the longest circadian period (24.9 h) of the group. We now find that this person can be entrained to 0.5 mg of melatonin, but not to 20 mg. These results are consistent with the idea that too much melatonin may spill over onto the wrong zone of the melatonin phase-response curve.
Lewy
Alfred J
AJ
Department of Psychiatry, Oregon Health & Science University, Portland, USA.
Emens
Jonathan S
JS
Sack
Robert L
RL
Hasler
Brant P
BP
Bernert
Rebecca A
RA
D000284:Administration, Oral; D001766:Blindness / Q000150:complications* / Q000503:physiopathology; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008550:Melatonin / Q000008:administration & dosage*; D008875:Middle Aged; D020178:Sleep Disorders, Circadian Rhythm / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology
D008550:Melatonin