Radamycin, a novel thiopeptide produced by streptomyces sp. RSP9. II. Physico-chemical properties and structure determination.
The new cyclic peptide antibiotic, radamycin (1) and the known thiopeptide methylsulfomycin I (2) have been isolated from the fermentation broth of a Streptomyces sp. RSP9. The structure of radamycin was elucidated by NMR, LC-MS and FAB-MS and was established as a thiopeptide with oxazole and thiazole moieties, and several unusual amino acids.
Castro Rodríguez
Julián
J
Drug Discovery Division, Instituto Biomar S. A., León, Spain.
González Holgado
Gloria
G
Santamaría Sánchez
Ramón I
RI
Cañedo
Librada M
LM
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; C402917:methylsulfomycin I; C458901:radamycin