title: Myelofibrosis: response to busulfan after hydroxyurea failure.
abstract: We report a case of myelofibrosis with myeloid metaplasia (MMM) that responded dramatically to oral busulfan treatment after failure of hydroxyurea. Although busulfan treatment of this disease has fallen out of favour due to the favourable toxicity profile of hydroxyurea and reports of efficacy of interferon-alpha, our observation suggests there may still be a role for busulfan treatment of MMM in the setting of hydroxyurea or interferon failure or intolerance.
authors.affiliation: Department of Medicine, Wright State University School of Medicine, Dayton, Ohio 45428, USA.
authors.forename: T
authors.initials: T
authors.lastname: Naqvi
authors.forename: M A
authors.initials: MA
authors.lastname: Baumann
mesh_terms: D000477:Alkylating Agents / Q000627:therapeutic use*; D000963:Antimetabolites / Q000009:adverse effects / Q000627:therapeutic use; D002066:Busulfan / Q000627:therapeutic use*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000188:drug therapy*; D017211:Treatment Failure
chemical_list: D000477:Alkylating Agents; D000963:Antimetabolites; D002066:Busulfan; D006918:Hydroxyurea