KSR--a regulator and scaffold protein of the MAPK pathway.
Raabe and Rapp discuss how the scaffolding proteins may spatially localize mitogen-activated protein kinase (MAPK) signaling cassettes to allow signaling specificity. They focus on the adaptor kinase suppressor of Ras (KSR) and describe how the interactions between KSR and other proteins and the subcellular localization of KSR are regulated by phosphorylation.
Raabe
Thomas
T
University of W rzburg, Institut fuer Medizinische Strahlenkunde und Zellforschung (MSZ), Versbacherstrasse 5, 97078 W rzburg, Germany. raabe@biozentrum.uni-wuerzburg.de
Rapp
Ulf R
UR
D000818:Animals; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology*; D011494:Protein Kinases / Q000502:physiology*
D011494:Protein Kinases; C097199:KSR-1 protein kinase