Acute gliclazide administration enhances glucose and ketone body utilization in the perfused hind limb of normal and streptozotocin-diabetic rats.
Sulfonylureas are the most commonly used oral hypoglycemic agents. Their hypoglycemic actions are produced not only by stimulating insulin secretion but also by extrapancreatic mechanisms. Some groups have already demonstrated the extrapancreatic actions of sulfonylureas on carbohydrate metabolism in the liver, fat and muscle. In this study, we showed in an in situ perfused hind limb preparation of STZ-diabetic rats that gliclazide has an acute effect on ketone body and glucose utilization.
Okuda
Y
Y
Division of Endocrinology and Metabolism, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, 305-8575, Tsukuba, Japan. y-okuda@md.tsukuba.ac.jp
Kobayashi
K
K
Ohmori
H
H
Sone
H
H
Suzuki
M
M
Ma
J
J
Nakajima
T
T
Yamada
N
N
Yamashita
K
K
Suzuki
S
S
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005215:Fasting; D005907:Gliclazide / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D006614:Hindlimb / Q000098:blood supply; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007657:Ketone Bodies / Q000097:blood*; D008297:Male; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007657:Ketone Bodies; D005907:Gliclazide; D005947:Glucose