title: Helicobacter pylori stool antigen test: a method to confirm eradication in children.
abstract: We evaluated an antigen-based stool assay as an indicator of Helicobacter pylori (Hp) status during treatment aimed at eradicating Hp in 22 Hp-positive patients and 63 negative control patients. The sensitivity and specificity of the assay was 100% and 70%, respectively, when the manufacturer's cutoff was used. When we used the cutoff calculated from a receiver operating characteristic curve, the specificity of this test increased. Under these conditions, the test could be used in monitoring treatment and verifying eradication of Hp infection. Further studies must be carried out to standardize the cutoff in children.
authors.affiliation: Department of Pediatrics, University Medical School, Milan, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Roggero
authors.forename: Arianna
authors.initials: A
authors.lastname: Bonfiglio
authors.forename: Sergio
authors.initials: S
authors.lastname: Luzzani
authors.forename: Alberto
authors.initials: A
authors.lastname: Valadè
authors.forename: Elena
authors.initials: E
authors.lastname: Cataliotti
authors.forename: Giovanna
authors.initials: G
authors.lastname: Corno
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Garlaschi
authors.forename: Emanuela
authors.initials: E
authors.lastname: Carissimi
authors.forename: Fabio
authors.initials: F
authors.lastname: Mosca
authors.forename: Vittorio
authors.initials: V
authors.lastname: Carnelli
mesh_terms: D000293:Adolescent; D000942:Antigens, Bacterial / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000382:microbiology*; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D000942:Antigens, Bacterial