MAPK signaling specificity: it takes two to tango.
A surprisingly limited repertoire of core signaling pathways generates an enormous diversity of responses, often in a cell type-specific manner. Even within one cell, a single pathway might yield two different responses depending on the input signal. In budding yeast, a mitogen-activated protein kinase (MAPK) module seems to transmit both mating pheromone and invasive growth signals in the same yeast cell. We discuss recent insights into mechanisms of differential MAPK activation in this system.
Breitkreutz
Ashton
A
Samuel Lunenfeld Research Institute, Room 1080, Mt Sinai Hospital, Toronto, Canada.
Tyers
Mike
M
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D004789:Enzyme Activation; D038181:FMN Reductase; D020935:MAP Kinase Signaling System / Q000187:drug effects; D000072235:Mating Factor; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology; D012098:Reproduction / Q000187:drug effects; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D004718:Saccharomycetales / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development / Q000378:metabolism*; D013379:Substrate Specificity
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D010455:Peptides; C080321:STE5 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D000072235:Mating Factor; D038181:FMN Reductase; D009247:NADH, NADPH Oxidoreductases; C023903:ferric citrate iron reductase; C075580:FUS3 protein, S cerevisiae; D020928:Mitogen-Activated Protein Kinases