Hydromorphone metabolites: isolation and identification from pooled urine samples of a cancer patient.
1. Hydromorphone-3-glucuronide, dihydromorphine, dihydroisomorphine, dihydromorphine-3-glucuronide and dihydroisomorphine-3-glucuronide were isolated from a cancer patient's urine and identified as metabolites of hydromorphone by comparison with synthetic standards using LC/MS/MS with gradient elution. 2. The relative urinary recovery of dihydroisomorphine-3-glucuronide was estimated to be 17-fold higher than previously reported. 3. Three new metabolites, including hydromorphone-3-sulphate, norhydromorphone and nordihydroisomorphine, were tentatively identified.
Zheng
M
M
Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC V6T 1Z3, Canada.
McErlane
K M
KM
Ong
M C
MC
D000701:Analgesics, Opioid / Q000737:chemistry / Q000378:metabolism* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D004090:Dihydromorphine / Q000652:urine; D005260:Female; D005965:Glucuronates / Q000652:urine; D020719:Glucuronides / Q000737:chemistry / Q000652:urine; D006801:Humans; D004091:Hydromorphone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism* / Q000652:urine; D013058:Mass Spectrometry; D015394:Molecular Structure; D009369:Neoplasms / Q000378:metabolism / Q000652:urine
D000701:Analgesics, Opioid; D005965:Glucuronates; D020719:Glucuronides; C093624:hydromorphone-3-glucuronide; D004090:Dihydromorphine; D004091:Hydromorphone