PTHrP-producing tumor: squamous cell carcinoma of the liver accompanied by humoral hypercalcemia of malignancy, increased IL-6 and leukocytosis.
A 77-year-old man was admitted to our hospital showing symptoms of general fatigue and appetite loss. He had leukocytosis, thrombocytosis and hypercalcemia with elevated serum levels of parathyroid hormone related peptide (PTHrP) and interleukin-6 (IL-6). An increase in tumor markers SCC and CYFURA21-1 was observed. The liver contained a huge tumor, which was proved to be PTHrP producing squamous cell carcinoma by immuno-histochemical analysis. Since the tumor did not express IL-6, it was assumed to be induced by PTHrP in osteoblasts. This is the first report of PTHrP producing squamous cell carcinoma of the liver.
Asanuma
Nobuyuki
N
Department of Internal Medicine, Aizenbashi Hospital, Osaka.
Hagiwara
Keisuke
K
Matsumoto
Ikuko
I
Matsuda
Masahiro
M
Nakamura
Fumiaki
F
Kouhara
Haruhiko
H
Miyamoto
Makoto
M
Miyashita
Yoshihiro
Y
Noguchi
Sanai
S
Morimoto
Yasuhiko
Y
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D002118:Calcium / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006934:Hypercalcemia / Q000097:blood*; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000097:blood; D007964:Leukocytosis / Q000097:blood; D008113:Liver Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D044162:Parathyroid Hormone-Related Protein; D036361:Peptide Hormones / Q000097:blood*; D011859:Radiography; D013922:Thrombocytosis / Q000097:blood
D014408:Biomarkers, Tumor; D015850:Interleukin-6; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D036361:Peptide Hormones; D002118:Calcium