title: Effects of ipriflavone on bone augmentation within a titanium cap in rabbit calvaria.
abstract: Ipriflavone (7-isopropoxyisoflavone, IP), a drug used in the treatment of osteoporosis, may promote bone formation during bone remodeling. IP has been shown to accelerate both the activity of, and formation of mineralized nodules by a human osteosarcoma cell line at an early stage. However, the direct effects of IP on bone augmentation have not been investigated. The purpose of this study was to determine whether IP induces bone augmentation within a titanium cap in rabbit calvaria at an early stage. Five adult male Japanese white rabbits were used. One cap (test site) was packed with IP in a collagen gel, and the other (control site) was packed with the collagen gel alone. After the one- and three-month healing periods, we measured the newly generated tissue and bone within the titanium caps. The amount of newly generated tissue within the titanium caps of the control sites was higher than the tests sites after one month and three months. However, the percentage of newly generated bone/bone marrow in the newly generated tissue at the test sites was higher than for the control sites after one month and three months. These results suggest that IP affects the quality of bone augmentation at an early stage.
authors.affiliation: Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan. minegishi-t@dent.nihon-u.ac.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Minegishi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kawamoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamada
authors.forename: Maiko
authors.initials: M
authors.lastname: Oshikawa
authors.forename: Mamoru
authors.initials: M
authors.lastname: Kishida
authors.forename: Shuichi
authors.initials: S
authors.lastname: Sato
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology; D001861:Bone Regeneration / Q000187:drug effects; D016723:Bone Remodeling / Q000187:drug effects*; D002113:Calcification, Physiologic / Q000187:drug effects; D003094:Collagen; D004337:Drug Carriers; D007091:Image Processing, Computer-Assisted; D007529:Isoflavones / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D010027:Osteotomy / Q000295:instrumentation; D010521:Periosteum / Q000601:surgery; D010865:Pilot Projects; D011817:Rabbits; D012886:Skull / Q000187:drug effects* / Q000502:physiology / Q000601:surgery; D018709:Statistics, Nonparametric; D013524:Surgical Flaps; D013997:Time Factors; D014025:Titanium; D014945:Wound Healing
chemical_list: D004337:Drug Carriers; D007529:Isoflavones; C059821:atelocollagen; C018986:ipriflavone; D003094:Collagen; D014025:Titanium