title: In vitro bioactivity of a biocomposite fabricated from HA and Ti powders by powder metallurgy method.
abstract: Traditionally, hydroxyapatite was used as a coating material on titanium substrate by various techniques. In the present work, a biocomposite was successfully fabricated from hydroxyapatite and titanium powders by powder metallurgy method. Bioactivity of the composite in a simulated body fluid (SBF) was investigated. Main crystal phases of the as-fabricated composite are found to be Ti2O, CaTiO3, CaO, alpha-Ti and a TiP-like phase. When the composite is immersed in the simulated body fluid for a certain time, a poor-crystallized, calcium-deficient, carbonate-containing apatite film will form on the surface of the composite. The time required to induce apatite nucleation is within 2 h. In addition, the apatite is also incorporated with a little magnesium and chlorine element. It is found that Ti2O has the ability to induce the formation of bone-like apatite in the SBF. And a dissolve of the CaO phase could also provide favorable conditions for the apatite formation, by forming open pores on the surface of the composite and increasing the degree of supersaturation of the SBF with respect to the apatite.
authors.affiliation: School of Materials Science and Engineering, Harbin Institute of Technology, People's Republic of China. cqning@yahoo.com
authors.forename: C Q
authors.initials: CQ
authors.lastname: Ning
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D001031:Apatites / Q000737:chemistry*; D001672:Biocompatible Materials; D001826:Body Fluids / Q000737:chemistry / Q000378:metabolism; D018786:Bone Substitutes; D002118:Calcium / Q000737:chemistry; D003460:Crystallization; D017886:Durapatite / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008669:Metallurgy / Q000379:methods; D008855:Microscopy, Electron, Scanning; D010100:Oxygen; D011208:Powders; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D018786:Bone Substitutes; D011208:Powders; D017886:Durapatite; D014025:Titanium; D010100:Oxygen; D002118:Calcium