[Effect of products of germ-line and somatic gene mutations on chromatin remodeling].
Chromatin remodeling is engaged in basic cell functions as DNA replication, recombination, DNA repair and transcription of genes. Chromatin is remodeled by ATP-dependent chromatin remodeling complexes and protein complexes covalently modifying histones. Germ-line mutations of the genes coding for proteins which participate in chromatin remodeling cause severe developmental diseases and they increase a risk of cancer development. Somatic mutations and translocations of such genes are associated with cancer development of certain tumors. Chromatin remodeling mechanisms can thus be targeted by special strategy of cancer therapy.
Smardová
J
J
Masarykův onkologický ústav, Brno. smardova@mou.cz
Smarda
J
J
D002843:Chromatin / Q000235:genetics* / Q000378:metabolism*; D015316:Genetic Therapy; D018095:Germ-Line Mutation; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000235:genetics; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000628:therapy
D002843:Chromatin; D006657:Histones
Důsledky vrozených a somatických mutací genů, jejichz produkty se úcastní prestavby chromatinu.