title: Quantification of brain gray matter damage in different MS phenotypes by use of diffusion tensor MR imaging.
abstract: OBJECTIVE
  Increasing evidence exists that cerebral gray matter (GM) from patients with multiple sclerosis (MS) is not spared. This study was performed to quantify in vivo the extent of cerebral GM pathologic abnormality in patients with relapsing-remitting (RR), secondary progressive (SP), and primary progressive MS, by using diffusion tensor (DT) MR imaging.
  
  
  METHODS
  Dual-echo and DT MR imaging of the brain were performed in 102 patients with MS and 30 healthy volunteers. After GM segmentation using a technique based on diffusion anisotropy thresholding, average diffusivity (D) histograms of the cerebral GM were produced for all participants.
  
  
  RESULTS
  All D histogram-derived metrics of the GM were significantly different between control volunteers and the whole MS population. No significant difference was found for any of the D histogram-derived metrics between control volunteers and patients with RRMS, whereas significant differences were found for D and D histogram peak location between control volunteers and patients with PPMS. All the D histogram-derived metrics differed significantly between patients with RRMS and patients with SPMS. Patients with SPMS also had significantly lower D than did patients with PPMS. All D histogram-derived metrics of the GM were strongly correlated with the T2 lesion volume.
  
  
  CONCLUSIONS
  This study confirms the presence of brain GM changes in patients with MS. It also shows that the extent of such changes is greater during the progressive forms of the disease.
authors.affiliation: Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Bozzali
authors.forename: Mara
authors.initials: M
authors.lastname: Cercignani
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Sormani
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Comi
authors.forename: Massimo
authors.initials: M
authors.lastname: Filippi
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000175:diagnosis*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis*; D010487:Periaqueductal Gray / Q000473:pathology*