Prognostic value of the clinical and laboratory evaluation in patients with nonmosaic Klinefelter syndrome who are receiving assisted reproductive therapy.
OBJECTIVE
To characterize clinical and laboratory findings in nonmosaic 47,XXY patients that may help to predict spermatogenetic activity in their testicles.


METHODS
Prospective study.


METHODS
Assisted reproductive technology program.


METHODS
Twenty patients with nonmosaic Klinefelter syndrome who underwent testicular sperm retrieval for IVF.


METHODS
The correlation between basal FSH, LH and testosterone levels, mean testicular volume, and results of the hCG test and presence or absence of sperm after testicular sperm extraction (TESE).


RESULTS
Sperm was found in nine patients (45%). The mean testicular volume was 7.8 +/- 2.5 mL in men with sperm after TESE and 5.6 +/- 1.2 mL in those without sperm after TESE; corresponding testosterone levels were 3.5 +/- 1.2 ng/mL and 1.7 +/- 0.8 ng/mL. Serum levels of FSH and LH did not significantly differ between groups. After the hCG test, the mean serum testosterone level was 16.0 +/- 6.3 ng/mL in men with sperm after TESE and 6.7 +/- 5.6 ng/mL in those without sperm.


CONCLUSIONS
Testicular volume, testosterone levels, and results of the hCG test are important predictive factors of spermatogenesis in patients with nonmosaic Klinefelter syndrome.
Madgar
Igael
I
Male Infertility, Department of Urology and Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
Dor
Jehoshua
J
Weissenberg
Ruth
R
Raviv
Gil
G
Menashe
Yehezkel
Y
Levron
Jacob
J
D000328:Adult; D006063:Chorionic Gonadotropin; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007713:Klinefelter Syndrome / Q000097:blood* / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009030:Mosaicism; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D013094:Spermatozoa / Q000473:pathology; D013737:Testis / Q000473:pathology; D013739:Testosterone / Q000097:blood; D020858:Tissue and Organ Harvesting
D006063:Chorionic Gonadotropin; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone