title: Physical performance and prediction of 2-5A synthetase/RNase L antiviral pathway activity in patients with chronic fatigue syndrome.
abstract: The elevated RNase L enzyme activity observed in some Chronic Fatigue Syndrome (CFS) patients may be linked to the low exercise tolerance and functional impairment that typify this disease. The purpose of this investigation was to determine if specific indicators of physical performance can predict abnormal RNase L activity in CFS patients. Seventy-three CFS patients performed a graded exercise test to voluntary exhaustion. Forty-six patients had elevated RNase L levels. This measure was employed as the dependent variable in a discriminant function analysis, with peak V02, exercise duration and Karnofsky Performance Scores (KPS) serving as the independent variables. All three variables entered the single significant function (p < 0.001). The elevated RNase L group had a lower peak V02 and duration than the normal group, but a higher KPS. The results suggest that both exercise testing and the RNase L biomarker have potential to aid in the diagnosis of CFS.
authors.affiliation: Department of Sport Sciences, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211-0197, USA.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Snell
authors.forename: J Mark
authors.initials: JM
authors.lastname: Vanness
authors.forename: David R
authors.initials: DR
authors.lastname: Strayer
authors.forename: Staci R
authors.initials: SR
authors.lastname: Stevens
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism*; D004722:Endoribonucleases / Q000378:metabolism*; D005080:Exercise Test; D015673:Fatigue Syndrome, Chronic / Q000201:enzymology / Q000503:physiopathology*; D006801:Humans; D018763:Muscle Fatigue; D010101:Oxygen Consumption; D012016:Reference Values
chemical_list: D015088:2',5'-Oligoadenylate Synthetase; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease