title: Amyloid a protein amyloidosis in a patient with plasma cell dyscrasia.
abstract: We report a 59-year-old man who was found to have plasma cell dyscrasia and amyloid A protein (AA) amyloidosis during the follow-up period of chronic inactive hepatitis C. Clinical manifestations such as swallowing disturbance, proteinuria and leg edema were associated with AA amyloid deposits in his tongue and kidneys. Although the relationship between these two diseases remains to be determined, the ability of peripheral blood mononuclear cells to degradate serum amyloid A protein was apparently reduced in this patient, compared with normal volunteers. This would, in part, account for the AA amyloid deposition in this patient.
authors.affiliation: First Department of Internal Medicine, Nagasaki University School of Medicine.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nakata
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Aritomi
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ohkubo
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Migita
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hamasaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamasaki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakao
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kato
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
mesh_terms: D000686:Amyloidosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D003224:Congo Red; D005753:Gastric Mucosa / Q000473:pathology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007122:Immunoelectrophoresis; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D000685:Serum Amyloid A Protein / Q000378:metabolism*
chemical_list: D000685:Serum Amyloid A Protein; D003224:Congo Red