title: [Moyamoya and Down syndrome: study conducted by meta-analysis].
abstract: We present a clinic-epidemiological study of two patients and meta-analysis (period 1977-2000 ) of the co-morbidity of the Down syndrome (DS) and moyamoya syndrome (MMS). Among the 42 patients listed in this survey, meta-analysis permitted to find the highest number of publications by researchers from Japan and United States, followed by Brazil and Italy; prevalence of cerebrovascular disease in suckling and pre school children; first symptomatology was hemiparesis (78.6%), speech disorders (26.2%); ischemic infarction (76.2%); recurring ischemic episodes (62%); bilateral impairment (83.3%). This analysis led to the conclusion that in the clinic-neurological investigation of DS patients with acute hemiparesis episodes, MMS should be included as the most probable diagnosis.
authors.affiliation: Departamento de Neurologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil. ppaj@terra.com.br
authors.forename: Paulo Alves
authors.initials: PA
authors.lastname: Junqueira
authors.forename: Maria Valeriana L de
authors.initials: MV
authors.lastname: Moura-Ribeiro
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002533:Cerebral Angiography; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D009072:Moyamoya Disease / Q000150:complications* / Q000175:diagnosis; D020521:Stroke / Q000150:complications / Q000000981:diagnostic imaging; D014463:Ultrasonography
vernacular_title: Síndrome de Down e Moyamoya: estudo através de metanálise.