[Effect of bemythyl on carbohydrate metabolism in cirrhotic rat liver].
Effect of actoprotector bemitil (2-ethylthiobenzimidazole hydrobromide) on glycogen content and activities of glycogen synthase, glycogen phosphorylase, and glucose-6-phosphatase was studied in cirrhotically altered rat liver. The contents of glycogen and its fraction were determined a cytofluorimetrically (Kudryavtseva et al., 1974). In cirrhosis, the total glycogen content in hepatocytes increases by nearly 3 times, while the amount of a stable fraction of glycogen rises by 7.5 times. Glucose-6-phosphatase activity fell to the level of 25% compare to the norm. Activities of glycogen synthase and glycogen phosphorylase in the cirrhotic liver did not differ from the norm. In cirrhotically altered liver, bemitil produced a decrease in the total glycogen content due to a decrease in glycogen synthase activity in an increase in glucose-6-phosphatase and glycogen phosphorylase activities. The above results suggest a favorable effect of bemitil on cirrhotic liver.
Kudriavtseva
M V
MV
Institute of Cytology RAS, St. Petersburg.
Bezborodkina
N N
NN
Okovityĭ
S V
SV
Nilova
V K
VK
Ivanikova
N V
NV
Kudriavtsev
B N
BN
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D002241:Carbohydrates / Q000494:pharmacology*; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D024981:Glycogen Phosphorylase / Q000378:metabolism; D006006:Glycogen Synthase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008106:Liver Cirrhosis, Experimental / Q000201:enzymology / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051381:Rats
D001562:Benzimidazoles; D002241:Carbohydrates; D008112:Liver Glycogen; C049825:bemethyl; D024981:Glycogen Phosphorylase; D006006:Glycogen Synthase; D005952:Glucose-6-Phosphatase
Issledovanie vliianiia bemitila na uglevodnyĭ obmen tsirroticheski izmenennoĭ pecheni krys.