[Sibling cases of nephritis resembling membranoproliferative glomerulonephritis].
We have experienced rare cases of membranoproliferative glomerulonephritis (MPGN)-like nephritis, which was seen in siblings. Both the brothers had asymptomatic hematuria and proteinuria at an age before 10, 7 and 4 years old, respectively. Renal biopsy revealed proliferative glomerulonephritis, resembling MPGN type III. The family history showed that their father and grandfather suffered from end-stage renal disease, suggesting that MPGN seen in the present sibling cases is hereditary. A review of the literature revealed that familial MPGN is rare, that most of the cases have urinary abnormalities at an age of less than 10 years, and that male preponderance is seen in familial MPGN.
Ueda
Hideki
H
Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
Isimura
Eiji
E
Okuno
Senji
S
Maekawa
Kiyoshi
K
Izumotani
Tsuyoshi
T
Kim
Masao
M
Matsumoto
Naoki
N
Fukumoto
Shinya
S
Imanishi
Yasuo
Y
Emoto
Masanori
M
Shoji
Tetsuo
T
Wanibuchi
Hideki
H
Inaba
Masaaki
M
Nishizawa
Yoshiki
Y
D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005192:Family Health; D015432:Glomerulonephritis, Membranoproliferative / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D009393:Nephritis / Q000235:genetics* / Q000473:pathology