title: A new method for diagnosing fever of unknown origin (FUO) due to infection of muscular-skeletal system in elderly people: leukoscan Tc-99m labelled scintigraphy.
abstract: Twenty patients affected by fever of unknown origin (FUO), due to a likely infection of the muscular or skeletal tissues, were studied by a Total Body scan with a monoclonal antibody fragment (Leukoscan) labelled with Tc-99m. The diagnostic procedure helped reach a final diagnosis in 8 out of the 20 patients because it identified the focus of the infection of the muscles or bones in joint proximity. Our data show that Leukoscan deserves to become a first line diagnostic procedure in the diagnostic algorithm for the evaluation of patients with FUO.
authors.affiliation: Department of Senescent, Urological, and Neurological Sciences, Institute of Internal Medicine and Geriatrics, University of Catania, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Maugeri
authors.forename: A
authors.initials: A
authors.lastname: Santangelo
authors.forename: S
authors.initials: S
authors.lastname: Abbate
authors.forename: I
authors.initials: I
authors.lastname: Rizza
authors.forename: A
authors.initials: A
authors.lastname: Calanna
authors.forename: A
authors.initials: A
authors.lastname: Lentini
authors.forename: M
authors.initials: M
authors.lastname: Malaguarnera
authors.forename: S
authors.initials: S
authors.lastname: Speciale
authors.forename: M
authors.initials: M
authors.lastname: Testai
authors.forename: P
authors.initials: P
authors.lastname: Panebianco
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D005260:Female; D005335:Fever of Unknown Origin / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D007239:Infections / Q000150:complications*; D008297:Male; D009140:Musculoskeletal Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D019275:Radiopharmaceuticals; C101172:Sulesomab