A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues.
[structure: see text] A modified approach to the synthesis of 2-(N-aryl)-1,3-oxazoles, employing an optimized iminophosphorane/heterocumulene-mediated methodology, and its application to the synthesis of BMS-337197, a potent inhibitor of IMPDH, are described.
Dhar
T G Murali
TG
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000, USA. dharm@bms.com
Guo
Junqing
J
Shen
Zhongqi
Z
Pitts
William J
WJ
Gu
Henry H
HH
Chen
Bang-Chi
BC
Zhao
Rulin
R
Bednarz
Mark S
MS
Iwanowicz
Edwin J
EJ
D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry
D004791:Enzyme Inhibitors; D010080:Oxazoles; D007168:IMP Dehydrogenase; C460179:BMS-337197