[Benign prostatic hyperplasia: biological significance of lymphohistiocytic infiltration of the adenoma].
The presence of mononuclear cells infiltrating the prostate adenoma is a morphological observation well established in the literature. However, its biological meaning is a subject of controversy. It has been postulated that it may represent a local immunological reaction contributing to the pathogenesis of prostatic adenoma. Several studies have been performed to test this hypothesis, both in humans and animals. The purpose of this review is to update available information, including our own ongoing studies. Morphological research has shown that cells infiltrating the adenoma are lymphocyte T, lymphocyte B and macrophages with a high proportion of lymphocyte T. Many of the inflammatory markers, such as lymphoquines (IL1, IL2, IL4, IL6, IL13), are elevated in the adenoma tissue as are some growth factors (EGF, TGF alpha, IFN gamma, TGF beta). The general impression is that an inflammatory process is activated in the adenoma during growth and maturing. It has also been proved that this inflammatory process could be modified with treatment and, in our case, with the lipido-sterolic extract of Serenoa Repens.
Vela Navarrete
R
R
Departamentos de Urología, Anatomía Patológica e Investigación, Fundación Jiménez Díaz, Universidad Autónoma, Madrid.
García Cardoso
J
J
López Farre
A
A
Barat
A
A
Manzarbeitia
F
F
Ramírez
M
M
Montón
M
M
D006801:Humans; D008214:Lymphocytes; D008264:Macrophages; D008297:Male; D011470:Prostatic Hyperplasia / Q000276:immunology / Q000473:pathology*
Hiperplasia prostática benigna: significado biológico de la infiltración celular linfohistiocitaria del adenoma.