Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.
The gene encoding a transmembrane glycoprotein LIG-1, of which the extracellular region was organized with the leucine-rich repeats and immunoglobulin-like domains, was disrupted in mice by gene targeting. LIG-1-deficient mice developed a skin change on the tail and facial area after birth. The affected skin was histologically reminiscent of the epidermis in human common skin disease 'psoriasis'. LIG-1 was expressed in basal cells of the epidermis and outer root sheath cells of hair follicles in mice. Interestingly, the LIG-1 expression was apparently down-regulated in the psoriatic lesions, suggesting that LIG-1 inversely correlates with proliferative ability of epidermal keratinocytes.
Suzuki
Yutaka
Y
Read Generation Laboratory, Tanabe Seiyaku Co. Ltd., 3-16-89 Kashima, Yodogawa-ku, Osaka, Japan.
Miura
Hiroyuki
H
Tanemura
Atsushi
A
Kobayashi
Kinji
K
Kondoh
Gen
G
Sano
Shigetoshi
S
Ozawa
Kentaro
K
Inui
Shigeki
S
Nakata
Aya
A
Takagi
Tsutomu
T
Tohyama
Masaya
M
Yoshikawa
Kunihiko
K
Itami
Satoshi
S
D000015:Abnormalities, Multiple / Q000378:metabolism / Q000473:pathology; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D002455:Cell Division; D018076:DNA, Complementary; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D018390:Gene Targeting; D006801:Humans; D015603:Keratinocytes / Q000166:cytology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D011565:Psoriasis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D012868:Skin Abnormalities / Q000378:metabolism / Q000473:pathology
D018076:DNA, Complementary; C484445:LRIG1 protein, human; C101671:Lrig1 protein, mouse; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins