TGF-beta antagonists: why suppress a tumor suppressor?
Akhurst
Rosemary J
RJ
University of California-San Francisco, Mount Zion Cancer Research Institute, Room S231, Box 0875, 2340 Sutter Street, San Francisco, California 94143-0875, USA. rakhurst@cc.ucsf.edu
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D007074:Immunoglobulin G / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008113:Liver Neoplasms / Q000556:secondary*; D008175:Lung Neoplasms / Q000556:secondary*; D015674:Mammary Neoplasms, Animal / Q000473:pathology / Q000517:prevention & control*; D008546:Melanoma, Experimental / Q000473:pathology / Q000517:prevention & control*; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction; D051901:Smad4 Protein; D015534:Trans-Activators / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors*
D004268:DNA-Binding Proteins; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D018125:Receptors, Transforming Growth Factor beta; D011993:Recombinant Fusion Proteins; C497796:SMAD4 protein, human; D051901:Smad4 Protein; D015534:Trans-Activators; D016212:Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II