title: Cluster analysis of the codon use frequency of MHC genes from different species.
abstract: The relative synonymous codon use frequency of 135 MHC genes from four mammal species (Homo sapiens, Pan troglodyte, Macaca mulanta and Rattus norvegicus) is analyzed using a hierarchical cluster method. The result suggests that gene function is the dominant factor that determines codon usage bias, while species is a minor factor that determines further difference in codon usage bias for genes with similar functions. The conclusion may be useful in gene classification and gene function prediction.
authors.affiliation: Chien-Shiung Wu Laboratory, Southeast University, 210096 Jiangsu Province, Nanjing, People's Republic of China. jmma@seu.edu.cn
authors.forename: Jianmin
authors.initials: J
authors.lastname: Ma
authors.forename: Tong
authors.initials: T
authors.lastname: Zhou
authors.forename: Wanjun
authors.initials: W
authors.lastname: Gu
authors.forename: Xiao
authors.initials: X
authors.lastname: Sun
authors.forename: Zuhong
authors.initials: Z
authors.lastname: Lu
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D003062:Codon; D008253:Macaca mulatta; D008285:Major Histocompatibility Complex / Q000235:genetics*; D051381:Rats; D013045:Species Specificity
chemical_list: D003062:Codon