The renal tubular handling of aldosterone and its acid-labile conjugate.
Stop-flow studies using infusions of aldosterone-(3)H or its (3)H acid-labile conjugate were done on five rhesus monkeys. The aldosterone-(3)H urine-to-plasma (U/P) ratio decreased in the same distal urine samples as sodium. The (3)H acid-labile conjugate U/P-to-inulin U/P ratio increased in the more proximal samples either with conjugate formed endogenously during aldosterone-(3)H infusions or with labeled conjugate infused alone. Aldosterone reabsorption occurred at a distal site in the renal tubule, and secretion of its acid-labile conjugate occurred at a proximal site.
Scurry
M T
MT
Shear
L
L
Barry
K G
KG
D000450:Aldosterone / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D000818:Animals; D005260:Female; D007684:Kidney Tubules / Q000378:metabolism*; D008253:Macaca mulatta; D014316:Tritium
D014316:Tritium; D000450:Aldosterone