title: Treatment of Plasmodium falciparum malaria with quinine in children in Guinea-Bissau: one daily dose is sufficient.
abstract: We have earlier obtained good results in falciparum malaria by treating children with low doses of quinine for 7 days in Guinea-Bissau. In order to further simplify treatment, we compared outcome in 100 children with falciparum malaria treated in 1999/2000 for 7 days with 15 mg quinine salt/kg/dose twice daily (group I), 100 children treated with 7.5 mg quinine salt/kg/dose twice daily (group II), and 100 children treated with one single daily dose of 15 mg/kg. One day 28, parasites had reappeared in 12%, 15%, and 9%, respectively. These results are similar to what has been found after previous successful treatment regimens. Apart from a higher incidence of vomiting during the first 24 h of treatment in the groups treated with 15 mg/kg/dose no significant differences in symptoms or side-effects were found between the groups. In patients suffering from uncomplicated malaria, treatment with quinine can be simplified to one single dose of 15 mg/kg bodyweight whenever logistics make 2 daily doses less feasible.
authors.affiliation: Department of Paediatrics, Kolding Hospital, Denmark. pko@ks.vejleamt.dk
authors.forename: Poul-Erik
authors.initials: PE
authors.lastname: Kofoed
authors.forename: Fernando
authors.initials: F
authors.lastname: Có
authors.forename: Anja
authors.initials: A
authors.lastname: Poulsen
authors.forename: Claudina
authors.initials: C
authors.lastname: Cabral
authors.forename: Kathryn
authors.initials: K
authors.lastname: Hedegaard
authors.forename: Peter
authors.initials: P
authors.lastname: Aaby
authors.forename: Lars
authors.initials: L
authors.lastname: Rombo
mesh_terms: D000293:Adolescent; D000962:Antimalarials / Q000008:administration & dosage*; D002648:Child; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006169:Guinea-Bissau; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D011803:Quinine / Q000008:administration & dosage*
chemical_list: D000962:Antimalarials; D011803:Quinine