Neuroendocrine tumors of the lung: recent developments in histopathology.
Lung tumors with neuroendocrine differentiation are made up of several neoplasms with particular epidemiologic, clinical, morphologic, and molecular characteristics. Typical and atypical carcinoid tumors represent low-grade and intermediate-grade carcinomas, respectively, whereas small-cell carcinoma and large-cell neuroendocrine carcinoma are considered high-grade carcinomas. Recent studies support the use of this four-tumor, three-tier classification scheme, but in practice, definitive diagnoses on small tissue samples remain a challenge for even the most experienced lung pathologists.
Flieder
Douglas B
DB
Department of Pathology and Laboratory Medicine, Joan and Sanford I. Weill Medical College and Graduate School of Medical Sciences, New York Presbyterian Hospital, New York, New York 10021, USA. dbf2001@mail.med.cornell.edu
D002276:Carcinoid Tumor / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D018358:Neuroendocrine Tumors / Q000473:pathology*