Blockade by the cannabinoid CB(1) receptor antagonist, SR 141716, of alcohol deprivation effect in alcohol-preferring rats.
The present study investigated the effect of the cannabinoid CB(1) receptor antagonist, SR 141716 (N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazole-carboxamide), on alcohol deprivation effect (i.e. the temporary increase in alcohol intake after a period of alcohol withdrawal) in Sardinian alcohol-preferring (sP) rats. As expected, alcohol-deprived rats virtually doubled voluntary alcohol intake during the first hour of re-access. Acute administration of SR 141716 (0, 0.3, 1 and 3 mg/kg, i.p.) completely abolished the alcohol deprivation effect. These results suggest that the cannabinoid CB(1) receptor is part of the neural substrate mediating the alcohol deprivation effect and that SR 141716 may possess anti-relapse properties.
Serra
Salvatore
S
Neuroscienze S.c.a r.l., Via Palabanda 9, I-09123, Cagliari, Italy.
Brunetti
Giuliana
G
Pani
Marialaura
M
Vacca
Giovanni
G
Carai
Mauro A M
MA
Gessa
Gian Luigi
GL
Colombo
Giancarlo
G
D000428:Alcohol Drinking / Q000378:metabolism / Q000503:physiopathology*; D000704:Analysis of Variance; D000818:Animals; D002186:Cannabinoids / Q000378:metabolism*; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000037:antagonists & inhibitors* / Q000502:physiology; D000077285:Rimonabant; D013375:Substance Withdrawal Syndrome / Q000378:metabolism / Q000503:physiopathology*
D002186:Cannabinoids; D010880:Piperidines; D011720:Pyrazoles; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D000077285:Rimonabant