Inhibitory action of halothane on rat masculine sexual behavior and sperm motility.
Adult male rats were exposed to inhale halothane in the following regime: 15 ppm/4 h/5 days/week/9 weeks. Sexual behavior observations and sperm motility test were made before halothane exposure (0 days) and at 15, 30, 45 and 60 days of exposure. Fifteen days after halothane exposure, this anesthetic inhibited the proportion of animals displaying ejaculation. In those animals ejaculating, halothane produced an inhibition of masculine sexual behavior reflected as an increase in the intromission latency, number of mounts and postejaculatory interval. At 30 days after exposure, only an increase in the intromission latency was observed. At 45 and 60 days, the inhibitory effect of halothane on sexual behavior disappeared. Similarly, at 15 and 30 days, but not at 45 or 60 days of halothane exposure, a reduced sperm motility was observed. Such transient effects of halothane suggest the development of tolerance to the inhibitory actions of this anesthetic on sexual behavior and sperm motility. These halothane effects are in line with an inhibition of masculine sexual behavior after stimulation of the GABAergic system.
Oropeza-Hernández
Luis F
LF
Sección Externa de Toxicología, Cinvestav-IPN, Ave. IPN 2508, Col. Zacatenco, D.F. 07360, Mexico.
Quintanilla-Vega
Betzabet
B
Albores
Arnulfo
A
Fernández-Guasti
Alonso
A
D000280:Administration, Inhalation; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004542:Ejaculation / Q000187:drug effects; D005260:Female; D006221:Halothane / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D018685:Anesthetics, Inhalation; D005680:gamma-Aminobutyric Acid; D006221:Halothane