title: Nystatin and osmotica as chemical enhancers of the phenotypic adaptation to freeze-thaw stress in Geotrichum candidum ATCC 204307.
abstract: Geotrichum candidum is a yeast-like fungus used as ripening starter in cheese making. The present study focused on chemical stress pretreatments affecting survival of G. candidum ATCC 204307 to freeze-thaw stress. Cryotolerance of G. candidum cells was induced by pretreatment with NaCl, CaCl2, or MgCl2, indicating heterologous phenotypic adaptation to freeze-thaw stress (- 20 to 25 degrees C) by osmotic stress. Furthermore, the nystatin, an antifungal compound, was shown to be a cryotolerance inducer.
authors.affiliation: Laboratoire de Microbiologie Alimentaire, USC INRA, Université de Caen-Basse Normandie, Esplanade de la Paix, France.
authors.forename: Ségolène
authors.initials: S
authors.lastname: Dubernet
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Panoff
authors.forename: Bouachanh
authors.initials: B
authors.lastname: Thammavongs
authors.forename: Micheline
authors.initials: M
authors.lastname: Guéguen
mesh_terms: D000222:Adaptation, Physiological; D000935:Antifungal Agents / Q000494:pharmacology*; D003080:Cold Temperature; D015925:Cryopreservation / Q000379:methods; D005615:Freezing; D005848:Geotrichum / Q000254:growth & development*; D009761:Nystatin / Q000494:pharmacology*; D010641:Phenotype
chemical_list: D000935:Antifungal Agents; D009761:Nystatin