Vanilloid and TRP channels: a family of lipid-gated cation channels.
The emergence of the TRP (C) and vanilloid (TRPV) receptor family of Ca(2+) permeable channels has started to provide molecular focus to a linked group of ion channels whose common feature is activation primarily by intracellular ligands. These channels have a central role in Ca(2+) homeostasis in virtually all cells and in particular those that lack voltage-gated Ca(2+) channels. We will discuss recent work that is more precisely defining both molecular form and physiological function of this important group of Ca(2+) permeable channels with particular focus on the intracellular ligands that gate and modulate channel activity.
Benham
C D
CD
Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Harlow, UK.
Davis
J B
JB
Randall
A D
AD
D000818:Animals; D015220:Calcium Channels / Q000235:genetics / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D008055:Lipids / Q000502:physiology*; D011955:Receptors, Drug / Q000235:genetics / Q000502:physiology*; D050052:TRPC Cation Channels; D014158:Transcription, Genetic
D015220:Calcium Channels; D008055:Lipids; D011955:Receptors, Drug; D050052:TRPC Cation Channels