Cytotoxic and apoptosis-inducing ent-kaurane-type diterpenoids from the Japanese liverwort Jungermannia truncata NEES.
Five new ent-kaurane-type diterpenoids and a new gymnomitrane (=barbatane)-type sesquiterpenoid have been isolated from the Japanese liverwort Jungermannia truncata NEES, together with twelve previously known ent-kaurane-type diterpenoids. The structures of the new compounds were elucidated by two-dimensional (2D) NMR experiments and chemical reaction. Some of the isolated compounds showed cytotoxicity against human leukemia cell lines and induced apoptosis.
Nagashima
Fumihiro
F
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan. fnaga@ph.bunri-u.ac.jp
Kondoh
Masuo
M
Uematsu
Toshinari
T
Nishiyama
Akiko
A
Saito
Sayaka
S
Sato
Masao
M
Asakawa
Yoshinori
Y
D017209:Apoptosis; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D007564:Japan; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry*
D004224:Diterpenes