title: Phospholipids reduce adhesion formation in the rabbit uterine horn model.
abstract: OBJECTIVE
  To access the ability of intraperitoneal phospholipids to reduce adhesions in a standardized model for gynecologic operations.
  
  
  METHODS
  A randomized, experimental, blinded study using the double uterine horn model.
  
  
  METHODS
  Academic animal research laboratory.
  
  
  METHODS
  Thirty-three Chinchilla rabbits.
  
  
  METHODS
  Phospholipids or Ringer's lactate were intraperitoneally administered after bilateral uterine horn injury.
  
  
  METHODS
  After 10 days, adhesions were evaluated concerning area and strength as well as scores describing tenacity and degree.
  
  
  RESULTS
  Phospholipids (median 102.1 mm2) significantly reduce adhesion areas in comparison to surgical controls (median 392.2 mm2) and Ringer group (median 323.8 mm2). Scores reflecting severity and degree of adhesions support this finding.
  
  
  CONCLUSIONS
  These results prove the efficacy of phospholipids in the double uterine horn model. Future clinical studies are recommended.
authors.affiliation: Department of Surgery, Medical Faculty, Rhenish-Westphalian Technical University, Aachen, Germany. sa.mueller@chir.rwth-aachen.de
authors.forename: Stefan A
authors.initials: SA
authors.lastname: Müller
authors.forename: Karl H
authors.initials: KH
authors.lastname: Treutner
authors.forename: Hendrik
authors.initials: H
authors.lastname: Jörn
authors.forename: Michail
authors.initials: M
authors.lastname: Anurov
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Oettinger
authors.forename: Volker
authors.initials: V
authors.lastname: Schumpelick
mesh_terms: D000818:Animals; D005260:Female; D007274:Injections, Intraperitoneal; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D010743:Phospholipids / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D000077325:Ringer's Lactate; D012720:Severity of Illness Index; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control; D014591:Uterine Diseases / Q000473:pathology / Q000517:prevention & control*
chemical_list: D007552:Isotonic Solutions; D010743:Phospholipids; D000077325:Ringer's Lactate