[Specific inhibitors of cyclooxygenase type 2] ].
In the submitted review the author analyzes the ratio, function and role of two different forms of cyclooxygenases--cyclooxygenase type 1 and cyclooxygenase type 2--in the human organism. Special attention is devoted to specific inhibitors of cyclooxygenase type 2. Specific inhibition of COX-2 is associated with a lower incidence of undesirable reactions while the antiinflammatory and analgetic effect is preserved. Celecoxib and rofecoxib--the oldest representatives of drugs from this group were used in a number of clinical studies. The results of some of these studies are presented and commented.
Tomasová-Studýnková
J
J
3. lékarská fakulta UK, Revmatologický ústav, Praha.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D000068579:Celecoxib; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000502:physiology; D007783:Lactones / Q000009:adverse effects / Q000627:therapeutic use; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology; D011720:Pyrazoles; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use; D013450:Sulfones
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D007783:Lactones; D008565:Membrane Proteins; D011720:Pyrazoles; D013449:Sulfonamides; D013450:Sulfones; C116926:rofecoxib; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D000068579:Celecoxib
Specifické inhibitory cyklooxygenázy typu 2.