Attenuated heart rate responses to public speaking in individuals with alcohol dependence.
BACKGROUND
Because individuals with alcohol dependence (AD) have shown blunted cortisol responses to psychological stress, we assessed whether they also show attenuated cardiovascular responses. This study examined the cardiovascular responses of people meeting DSM-IV criteria for AD to orthostasis and public speaking.


METHODS
Heart rate (HR), stroke volume, cardiac output, total peripheral resistance, mean arterial pressure, systolic blood pressure, and diastolic blood pressure during orthostasis and public speaking were assessed by use of impedance cardiography and Dinamap blood pressure monitoring in 20 AD subjects abstinent for 21 to 28 days and in 10 age-matched controls. Orthostasis consisted of standing, whereas public speaking involved preparing and presenting two speeches. Self-reported mood state was also assessed during the tasks.


RESULTS
AD subjects had significantly lower resting BP compared with controls. Cardiovascular responses to orthostasis were similar between groups. AD subjects had attenuated HR during public speaking but reported similar anxiety responses to controls.


CONCLUSIONS
Comparable cardiovascular responses to orthostasis in controls and AD subjects suggest intact reflex control of circulation. AD subjects had blunted HR responses to public speaking; this is consistent with the attenuated cortisol responses observed in this sample and in previous studies. This suggests a possible alteration in limbic system regulation of hypothalamic and brainstem responses to psychological stress. Cardiovascular responses of AD subjects that are inconsistent with subjective accounts of tension and anxiety suggest a disconnection between perception of threat and resulting physiologic responses in AD subjects.
Panknin
Tera L
TL
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, USA.
Dickensheets
Stacey L
SL
Nixon
Sara J
SJ
Lovallo
William R
WR
D000328:Adult; D000437:Alcoholism / Q000503:physiopathology*; D000704:Analysis of Variance; D001794:Blood Pressure / Q000502:physiology; D004244:Dizziness / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012146:Rest / Q000502:physiology; D013060:Speech / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology