Recent advances in molecular biology of gestational trophoblastic diseases. A review.
Gestational trophoblastic diseases are interrelated conditions characterized by abnormal growth of chorionic tissues with various propensities for local invasion and metastasis. Complete mole is a unique conception in that all nuclear DNA is paternally derived and all cytoplasmic DNA is maternally derived. In contrast, partial mole generally has a triploid karyotype, where the extra haploid set of chromosomes is paternally derived: Gestational trophoblastic diseases are characterized by altered expression of several growth regulatory factors and oncogenes. While differences in expression of oncoproteins may be important to the development of gestational trophoblastic disease, the precise molecular changes that are critical to pathogenesis remain unknown.
Fulop
Vilmos
V
Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Mok
Samuel C
SC
Gati
Istvan
I
Berkowitz
Ross S
RS
D018450:Disease Progression; D005260:Female; D005819:Genetic Markers; D031901:Gestational Trophoblastic Disease / Q000235:genetics*; D006801:Humans; D011247:Pregnancy
D005819:Genetic Markers