The Sulfinator: predicting tyrosine sulfation sites in protein sequences.
Protein tyrosine sulfation is an important post-translational modification of proteins that go through the secretory pathway. No clear-cut acceptor motif can be defined that allows the prediction of tyrosine sulfation sites in polypeptide chains. The Sulfinator is a software tool that can be used to predict tyrosine sulfation sites in protein sequences with an overall accuracy of 98%. Four different Hidden Markov Models were constructed, each of them specialized to recognize sulfated tyrosine residues depending on their location within the sequence: near the N-terminus, near the C-terminus, in the center of a window with a size of at least 25 amino acids, as well as in windows containing several tyrosine residues.


BACKGROUND
The Sulfinator is accessible at (http://www.expasy.org/tools/sulfinator/).


BACKGROUND
Sulfinator documentation is accessible at (http://www.expasy.org/tools/sulfinator/sulfinator-doc.html).
Monigatti
Flavio
F
SWISS-PROT Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
Gasteiger
Elisabeth
E
Bairoch
Amos
A
Jung
Eva
E
D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D003628:Database Management Systems; D030562:Databases, Protein; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012680:Sensitivity and Specificity; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D013431:Sulfates / Q000378:metabolism*; D014443:Tyrosine / Q000235:genetics / Q000378:metabolism*
D011506:Proteins; D013431:Sulfates; D014443:Tyrosine