title: A volumetric MRI study of the entorhinal cortex in first episode neuroleptic-naive schizophrenia.
abstract: BACKGROUND
  Imaging studies have frequently reported volume loss of limbic structures in schizophrenia, yet there appears to be no quantitative data on entorhinal cortex volumes in patients with neuroleptic naive first-episode schizophrenia.
  
  
  METHODS
  The volume of the entorhinal cortices of 22 control subjects and 18 patients with neuroleptic-naïve first-episode schizophrenia were measured from magnetic resonance images (MRI) scans using recently designed anatomic criteria for MRI anatomy of the entorhinal cortex.
  
  
  RESULTS
  Smaller entorhinal volumes were found bilaterally in the schizophrenic patients. This volume loss did not correlate with items on the Positive and Negative Syndrome Scale.
  
  
  CONCLUSIONS
  These data suggest early involvement of the entorhinal cortex in schizophrenia.
authors.affiliation: Institut Philippe Pinel de Montréal, Montreal, Canada.
authors.forename: Christian C
authors.initials: CC
authors.lastname: Joyal
authors.forename: Mikko P
authors.initials: MP
authors.lastname: Laakso
authors.forename: Jari
authors.initials: J
authors.lastname: Tiihonen
authors.forename: Erkka
authors.initials: E
authors.lastname: Syvälahti
authors.forename: Harry
authors.initials: H
authors.lastname: Vilkman
authors.forename: Aki
authors.initials: A
authors.lastname: Laakso
authors.forename: Birgitta
authors.initials: B
authors.lastname: Alakare
authors.forename: Viljo
authors.initials: V
authors.lastname: Räkköläinen
authors.forename: Raimo K R
authors.initials: RK
authors.lastname: Salokangas
authors.forename: Jarmo
authors.initials: J
authors.lastname: Hietala
mesh_terms: D000328:Adult; D018728:Entorhinal Cortex / Q000473:pathology*; D017050:Episode of Care; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000473:pathology*; D013997:Time Factors