Serum E-cadherin concentrations and their response during laparoscopic and open cholecystectomy.
BACKGROUND
Elevated serum levels of the cell adhesion molecule E-cadherin have been associated with the presence of tissue injury and inflammation. We compared soluble E-cadherin response during laparoscopic and open cholecystectomy.


METHODS
The E-cadherin response to surgery was studied in 16 patients undergoing laparoscopic cholecystectomy and 12 patients undergoing open cholecystectomy. Serum E-cadherin levels were measured by an enzyme immunoassay (ELISA) preoperatively, 10 and 30 min after the commencement of surgery, and at 6 and 24 h following the operation.


RESULTS
Serum E-cadherin levels decreased progressively during laparoscopic cholecystectomy; their concentrations at 24 h after surgery were significantly lower when compared with preoperative values. In the open cholecystectomy group, serum E-cadherin levels did not differ from preoperative values at any time point. Serum E-cadherin concentrations at 24 h after surgery and the cumulative E-cadherin response were significantly higher in the open cholecystectomy group than in the laparoscopic group.


CONCLUSIONS
Compared with open cholecystectomy, the cumulative E-cadherin response is significantly reduced following laparoscopic cholecystectomy.
Karayiannakis
A J
AJ
Second Department of Surgery, Democritus University of Thrace, Medical School, 6 I. Kaviri Street, 68 100 Alexandroupolis, Greece. akarayan@usa.net
Syrigos
K N
KN
Savva
A
A
Polychronidis
A
A
Karatzas
G
G
Simopoulos
C
C
D015820:Cadherins / Q000097:blood*; D002763:Cholecystectomy / Q000009:adverse effects* / Q000379:methods*; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects* / Q000379:methods*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013312:Stress, Physiological / Q000097:blood / Q000601:surgery; D013997:Time Factors
D015820:Cadherins