title: Epitope identification and vaccine design for cancer immunotherapy.
abstract: The development of processes for engineering multi-epitope vaccines based on the identification and selection of epitope packages, along with vaccine design optimization using epitope placements and spacers to optimize processing efficacy, are reviewed. The Epimmune Inc epitope identification process has been applied to numerous cancer types, but also applies to infectious diseases. Epitope-analog efforts in novel vaccine design have also been explored and their uses in prophylactic and therapeutic applications are eagerly anticipated.
authors.affiliation: Epimmune Inc, San Diego, CA 92121, USA. asette@epimmune.com
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sette
authors.forename: Elissa
authors.initials: E
authors.lastname: Keogh
authors.forename: Glenn
authors.initials: G
authors.lastname: Ishioka
authors.forename: John
authors.initials: J
authors.lastname: Sidney
authors.forename: Shabnam
authors.initials: S
authors.lastname: Tangri
authors.forename: Brian
authors.initials: B
authors.lastname: Livingston
authors.forename: Denise
authors.initials: D
authors.lastname: McKinney
authors.forename: Mark
authors.initials: M
authors.lastname: Newman
authors.forename: Robert
authors.initials: R
authors.lastname: Chesnut
authors.forename: John
authors.initials: J
authors.lastname: Fikes
mesh_terms: D000818:Animals; D000939:Epitopes / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D016233:Immunotherapy, Active / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000939:Epitopes