title: GeneNet database: description and modeling of gene networks.
abstract: Almost all cellular processes in an organism are controlled by gene networks. Here we report on the analysis of gene networks functioning using two associated methods - data accumulation in GeneNet system and generalized chemical kinetic method for mathematical simulation of gene network functional dynamics. The technology of the usage of these methods is shown on the example of the gene network of macrophage activation.
authors.affiliation: Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia.
authors.forename: Nikolay A
authors.initials: NA
authors.lastname: Kolchanov
authors.forename: Eugenia A
authors.initials: EA
authors.lastname: Nedosekina
authors.forename: Elena A
authors.initials: EA
authors.lastname: Ananko
authors.forename: Vitaly A
authors.initials: VA
authors.lastname: Likhoshvai
authors.forename: Nikolay L
authors.initials: NL
authors.lastname: Podkolodny
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Ratushny
authors.forename: Irina L
authors.initials: IL
authors.lastname: Stepanenko
authors.forename: Olga A
authors.initials: OA
authors.lastname: Podkolodnaya
authors.forename: Elena V
authors.initials: EV
authors.lastname: Ignatieva
authors.forename: Yury G
authors.initials: YG
authors.lastname: Matushkin
mesh_terms: D000465:Algorithms; D019295:Computational Biology; D003198:Computer Simulation; D004247:DNA / Q000378:metabolism*; D030541:Databases, Genetic; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D008213:Lymphocyte Activation / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D014584:User-Computer Interface
chemical_list: D011506:Proteins; D012313:RNA; D004247:DNA