title: [Effects of nitric oxide on myocardial contraction function].
abstract: Nitric oxide (NO) produced by myocardial nitric oxide synthase has been implicated as a modulator of myocardial contraction [correction of contracion]. This paper reviewed the reports on myocardial contraction modulated by NO, its mechanism, and regulation of expression and activity of iNOS. NO was recently shown to produce biphasic contractile [correction of contratile] effects on myocardium: augmentation at low levels and depression at high levels. The up-regulation of inducible nitric oxide synthase (iNOS) often negatively modulates myocardial function.
authors.affiliation: Institute of Space Medico-Engineering, Beijing, China. Xiongjh@life.com.cn
authors.forename: Jiang-hui
authors.initials: JH
authors.lastname: Xiong
authors.forename: Ying-hui
authors.initials: YH
authors.lastname: Li
authors.forename: Jie-lin
authors.initials: JL
authors.lastname: Nie
authors.forename: Xiao-ying
authors.initials: XY
authors.lastname: Yu
mesh_terms: D000818:Animals; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000166:cytology / Q000201:enzymology; D009569:Nitric Oxide / Q000378:metabolism / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000378:metabolism*
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase