title: BeoBLAST: distributed BLAST and PSI-BLAST on a Beowulf cluster.
abstract: BeoBLAST is an integrated software package that handles user requests and distributes BLAST and PSI-BLAST searches to nodes of a Beowulf cluster, thus providing a simple way to implement a scalable BLAST system on top of relatively inexpensive computer clusters. Additionally, BeoBLAST offers a number of novel search features through its web interface, including the ability to perform simultaneous searches of multiple databases with multiple queries, and the ability to start a search using the PSSM generated from a previous PSI-BLAST search on a different database. The underlying system can also handle automated querying for high throughput work.
  
  
  BACKGROUND
  Source code is available under the GNU public license at http://bioinformatics.fccc.edu/
authors.affiliation: Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. jd_grant@fccc.edu
authors.forename: J D
authors.initials: JD
authors.lastname: Grant
authors.forename: R L
authors.initials: RL
authors.lastname: Dunbrack
authors.forename: F J
authors.initials: FJ
authors.lastname: Manion
authors.forename: M F
authors.initials: MF
authors.lastname: Ochs
mesh_terms: D003195:Computer Communication Networks; D003205:Computing Methodologies; D003628:Database Management Systems; D030541:Databases, Genetic; D016247:Information Storage and Retrieval / Q000379:methods*; D020407:Internet; D009317:National Library of Medicine (U.S.); D017421:Sequence Analysis; D014481:United States