title: Anti-hypertensive effect of water extract of danshen on renovascular hypertension through inhibition of the renin angiotensin system.
abstract: A study was designed to elucidate the mechanism of anti-hypertensive effects of danshen in the two-kidney, one clip (2K1C) Goldblatt renovascular hypertensive model, which is the renin-angiotensin system (RAS)-dependent hypertensive model. We investigated the effects of water extracts of danshen on the angiotensin converting enzyme (ACE) activities, systolic blood pressure (SBP), and hormone levels in the plasma of 2K1C rats. ACE activity was inhibited by the addition of danshen extract in a dose-dependent manner. SBP was decreased significantly after administration of danshen extract in 2K1C, whereas plasma renin activity (PRA) was not changed. The plasma concentration of aldosterone (PAC) was decreased significantly in 2K1C group administered with Danshen extract, whereas the plasma concentration of ANP was increased by administration of danshen extract for three weeks. These results suggest that danshen has an anti-hypertensive effect through the inhibition of ACE, an essential regulatory enzyme of RAS.
authors.affiliation: Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Korea.
authors.forename: Dae Gil
authors.initials: DG
authors.lastname: Kang
authors.forename: Yong Gab
authors.initials: YG
authors.lastname: Yun
authors.forename: Jang Hyun
authors.initials: JH
authors.lastname: Ryoo
authors.forename: Ho Sub
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000450:Aldosterone / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006978:Hypertension, Renovascular / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D014867:Water
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D010936:Plant Extracts; D014867:Water; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin