Chemically modified polysulfone hollow fibers with vinylpyrrolidone having improved blood compatibility.
Hydrophilic polysulfone membranes (PVP-PSf) were prepared from polysulfone membranes covalently conjugated with polyvinylpyrrolidone (PVP) on the surface. The immobilized amount of vinylpyrrolidone on PVP-PSf membranes was controlled by the amount of vinylpyrrolidone monomer in the reaction solution and the reaction time. The PVP-PSf membranes were found to be the most hydrophilic membranes among the polysulfone and surface-modified polysulfone membranes prepared in this study. This is explained by the long hydrophilic side chain of polyvinylpyrrolidone on the PVP-PSf membranes which contributes to the hydrophilic wiper on the hydrophobic PSf membranes. It was found that PVP-PSf membranes gave lower protein adsorption from a plasma solution than polysulfone and other surface-modified membranes (p < 0.01). This is attributed to the hydrophilic surface of the PVP-PSf membranes, because the hydrophilic surface is known to reduce the protein adsorption on the membranes. The PVP-PSf membranes showed a much suppressed number of adhering platelets on the surface than polysulfone and other surface-modified membranes (p < 0.01). It is suggested that the hydrophilic surface of the PVP-PSf membranes without ionic groups causes the suppression of platelet adhesion on the PVP-PSf membranes and that the long hydrophilic side chain of polyvinylpyrrolidone on PVP-PSf membranes contributes to the hydrophilic and hemocompatible wipers on the surface of the hydrophobic PSf membranes.
Higuchi
Akon
A
Department of Applied Chemistry, Seikei University, Musashino, Tokyo, Japan. higuchi@ch.seikei.ac.jp
Shirano
Kazunobu
K
Harashima
Masaharu
M
Yoon
Boo Ok
BO
Hara
Mariko
M
Hattori
Mitsuo
M
Imamura
Kazuo
K
D000327:Adsorption; D000328:Adult; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D001769:Blood / Q000378:metabolism*; D001792:Blood Platelets / Q000166:cytology / Q000648:ultrastructure; D002448:Cell Adhesion; D002462:Cell Membrane / Q000378:metabolism; D004952:Esters / Q000737:chemistry; D005260:Female; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D011760:Pyrrolidinones / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013450:Sulfones / Q000737:chemistry* / Q000494:pharmacology
D001672:Biocompatible Materials; D004952:Esters; D011108:Polymers; D011760:Pyrrolidinones; D013450:Sulfones; C017662:polysulfone P 1700; C042670:N-vinyl-2-pyrrolidinone