title: Decreased consumption of corticosteroids after selenium supplementation in corticoid-dependent asthmatics.
abstract: Selenium represents a trace element comprised in enzyme glutathion-peroxidase. It is anti-inflammatory activity is based on the elimination of hydroperoxides produced in the site of inflammation (scavenger of free oxygen radicals). The authors report the results of a pilot study with 17 corticodependent asthmatics (7 females, 10 males) aged 30-74 years, supplemented with the preparation of selenium (Se), in a daily dose of 200 micrograms during the follow-up lasting 96 weeks. We demonstrate the reduced consumption of both inhaled corticosteroids, manifested after 24 to 96 weeks of Se supplementation (SeS) (21.74 mg vs 15.81 mg, p < 0.009, 21.74 mg vs 15.32 mg, p < 0.007, respectively) and systemic corticosteroids after 48 weeks (294 mg vs 78 mg, p < 0.04) and 96 weeks of SeS (294 mg vs 104 mg, p < 0.04). These results correlated with the elevation of Se levels both in plasma and erythrocytes (p < 0.0003, p < 0.0003, respectively). No adverse effects were seen during the study and the tolerance of preparation was good. (Tab. 3, Ref. 17.)
authors.affiliation: Institute of Preventive and Clinical Medicine, Department of Clinical Immunology, Limbova 14, SK-833 01 Bratislava 37, Slovakia. gazdik@upkm.sk
authors.forename: F
authors.initials: F
authors.lastname: Gazdik
authors.forename: J
authors.initials: J
authors.lastname: Kadrabova
authors.forename: K
authors.initials: K
authors.lastname: Gazdikova
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015656:Respiratory Mechanics / Q000187:drug effects; D012643:Selenium / Q000008:administration & dosage*; D013256:Steroids
chemical_list: D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005938:Glucocorticoids; D013256:Steroids; D012643:Selenium