Uptake of acetaldehyde-modified (ethylated) low-density lipoproteins by mouse peritoneal macrophages.
The uptake of acetaldehyde-modified (ethylated) low-density lipoproteins (LDLs) by murine peritoneal macrophages is described and compared with the uptake of acetylated LDLs. The fluorescent marker DiI was used. No competition between ethylated and acetylated LDLs was observed. Ethylated LDL uptake was not inhibited by polyinosinic acid or fucoidin. Our conclusion is that uptake of ethylated and acetylated LDLs can be done by two different receptors.
Wehr
Hanna
H
Department of Genetics, Institute of Psychiatry and Neurology, Sobieskiego 1/9, 02-957, Warsaw, Poland. wehr@ipin.edu.pl
Mirkiewicz
Ewa
E
Rodo
Maria
M
Bednarska-Makaruk
Malgorzata
M
D000079:Acetaldehyde / Q000378:metabolism*; D000107:Acetylation; D000818:Animals; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D008297:Male; D051379:Mice
D008077:Lipoproteins, LDL; D000079:Acetaldehyde