[Value of the protein profile in the diagnosis of infectious endocarditis when hemolysis is present].
OBJECTIVE
Haptoglobin (H) and orosomucoid (O) are acute phase proteins that increase in a parallel manner. When hemolysis and inflammation are both present, study of the O-H couple on the protein profile may reveal an unknown hemolysis.


METHODS
To determine if hemolysis is more frequent during infectious endocarditis than during septicemia without valvulopathy or during valvulopathy without septicemia. Study of three groups of patients: 26 patients with infectious endocarditis, 13 patients with septicemia and 36 patients with valvulopathy without septicemia. Studied parameters were the O-H couple, hemoglobin and rate of O.


RESULTS
Hemolysis is clear in patients with endocarditis. The difference O-H is significantly more important during endocarditis than during septicemia without valvulopathy (P < 0.001) and during valvulopathy without sepsis (P < 0.001).


CONCLUSIONS
Study of the O-H couple may be useful for the diagnosis of endocarditis showing a difficult-to-diagnose hemolysis.
de Lacroix-Szmania
I
I
Service de médecine interne, centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94010 Créteil, France. isabelle.delacroix@chicreteil.fr
Hausfater
P
P
Dorent
R
R
Thiollieres
J M
JM
Foglietti
M J
MJ
Godeau
P
P
Piette
J C
JC
Cacoub
P
P
D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D004697:Endocarditis, Bacterial / Q000097:blood / Q000175:diagnosis*; D006242:Haptoglobins / Q000032:analysis*; D006349:Heart Valve Diseases / Q000097:blood / Q000175:diagnosis; D006461:Hemolysis; D006801:Humans; D007249:Inflammation; D009961:Orosomucoid / Q000032:analysis*; D018805:Sepsis / Q000097:blood / Q000175:diagnosis*
D015415:Biomarkers; D001798:Blood Proteins; D006242:Haptoglobins; D009961:Orosomucoid
Apport du profil protéique pour le diagnostic d'endocardite infectieuse quand il révèle une hémolyse.