title: At least thirty-four days of animal continuous perfusion by a newly developed extracorporeal membrane oxygenation system without systemic anticoagulants.
abstract: We developed an extracorporeal membrane oxygenation (ECMO) system with high antithrombogenicity and durability characteristics for prolonged continuous cardiopulmonary support. The oxygenator consists of a special hollow-fiber-type polyolefin gas-exchange membrane, which has an ultrathin dense layer in contact with the blood, in order to prevent plasma leakage during protracted use (Platinum Cube NCVC). The centrifugal pump (RotaFlow) is free of seals. The entire blood-contacting surface of the system is coated with a newly developed heparin material (Toyobo-NCVC coating). We performed a venoarterial bypass in a goat, and the ECMO system was driven for 34 days without systemic anticoagulants. Plasma leakage from the oxygenator did not occur, and sufficient gas exchange performance was maintained. Thrombus formation was hardly observed in the ECMO system except in the casing margins of the oxygenator. This ECMO system showed potential for long-term cardiopulmonary support with minimal or no use of systemic anticoagulants.
authors.affiliation: Department of Artificial Organs, National Cardiovascular Center, Osaka, Japan. nishinak@ri.ncvc.go.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nishinaka
authors.forename: Eisuke
authors.initials: E
authors.lastname: Tatsumi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Taenaka
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Katagiri
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohnishi
authors.forename: Kyoko
authors.initials: K
authors.lastname: Shioya
authors.forename: Toshihide
authors.initials: T
authors.lastname: Fukuda
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Oshikawa
authors.forename: Koichi
authors.initials: K
authors.lastname: Sato
authors.forename: Tomonori
authors.initials: T
authors.lastname: Tsukiya
authors.forename: Akihiko
authors.initials: A
authors.lastname: Homma
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Takewa
authors.forename: Hisateru
authors.initials: H
authors.lastname: Takano
authors.forename: Masaki
authors.initials: M
authors.lastname: Sato
authors.forename: Susumu
authors.initials: S
authors.lastname: Kashiwabara
authors.forename: Hidenori
authors.initials: H
authors.lastname: Tanaka
authors.forename: Kazunari
authors.initials: K
authors.lastname: Sakai
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D006041:Goats; D006323:Heart Arrest / Q000628:therapy*; D010477:Perfusion / Q000295:instrumentation*; D012131:Respiratory Insufficiency / Q000628:therapy*; D013997:Time Factors
chemical_list: D000925:Anticoagulants