title: Technical considerations in the application of intensity-modulated radiotherapy as a concomitant integrated boost for locally-advanced cervix cancer.
abstract: The technical aspects of IMRT applied to cervix cancer are discussed in this paper, as well as issues related to tumor delineation, target volume definitions, inverse planning, and IMRT delivery. A theoretical example illustrating how IMRT can accurately mimic dose distributions obtained using conventional planning plus HDR brachytherapy is also shown. The notion of clinical optimization parameters is introduced to account for the radiation delivery variables, which affect the overall treatment time. This is especially relevant to the possible introduction of intrafractional movement and resulting inaccuracy, as well as facility efficiency.
authors.affiliation: Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora 80010-0510, USA. Tracey.Schefter@UCHSC.EDU
authors.forename: Tracey E
authors.initials: TE
authors.lastname: Schefter
authors.forename: Brian D
authors.initials: BD
authors.lastname: Kavanagh
authors.forename: Qiuwen
authors.initials: Q
authors.lastname: Wu
authors.forename: Shidong
authors.initials: S
authors.lastname: Tong
authors.forename: Francis
authors.initials: F
authors.lastname: Newman
authors.forename: Steve
authors.initials: S
authors.lastname: Mccourt
authors.forename: Mark
authors.initials: M
authors.lastname: Arnfield
authors.forename: Stanley
authors.initials: S
authors.lastname: Benedict
authors.forename: Radhe
authors.initials: R
authors.lastname: Mohan
mesh_terms: D001918:Brachytherapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal; D012720:Severity of Illness Index; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*