title: Unaltered insulin sensitivity after resistance exercise bout by postmenopausal women.
abstract: OBJECTIVE
  The major aims of this study were to determine whether a single session of resistance exercise would alter insulin sensitivity, glucose effectiveness, and C-peptide response to glucose challenge in a group of previously sedentary, postmenopausal women.
  
  
  METHODS
  Ten postmenopausal women (aged 57.5 +/- 1.6 yr) were studied. Each participant underwent two frequently sampled intravenous glucose tolerance tests (FSIVGTT): without prior exercise (no exercise), and postexercise (15 h after a session of resistance exercise: three sets of 10 repetitions performed at 50%, 75%, and 100% of 10-repetition maximum for 7 exercises). Insulin sensitivity and glucose effectiveness were determined according to Bergman's minimal model procedure. In addition, C-peptide concentration and glucose disappearance were measured.
  
  
  RESULTS
  There was no significant difference between trials for insulin sensitivity, glucose effectiveness, glucose disappearance, or area under the curve (AUC) for glucose or insulin during the glucose challenge. AUC for C-peptide tended (P = 0.059) to be 10% higher in the postexercise versus no exercise trial, and C-peptide values were significantly (P < or = 0.02) higher at several time points (60, 70, 140, and 180 min) during the postexercise compared with no exercise trial.
  
  
  CONCLUSIONS
  In contrast to previously reported results with young men and women after a single bout of endurance exercise, insulin sensitivity was unaltered by a single session of resistance exercise in postmenopausal women. Higher plasma C-peptide values concomitant with unchanged insulin values provide evidence that resistance exercise may have induced a slightly higher insulin secretion and a proportional increase in insulin clearance.
authors.affiliation: Department of Kinesiology, University of Wisconsin-Madison, 53706, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Chapman
authors.forename: Ann W
authors.initials: AW
authors.lastname: Garvin
authors.forename: Ann
authors.initials: A
authors.lastname: Ward
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Cartee
mesh_terms: D019540:Area Under Curve; D002096:C-Peptide / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004032:Diet; D015444:Exercise / Q000502:physiology*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology*; D014891:Weight Lifting / Q000502:physiology*
chemical_list: D002096:C-Peptide; D007328:Insulin; D003402:Creatine Kinase; D005947:Glucose