title: Primary hyperparathyroidism with duodenal ulcer and H. pylori infection.
abstract: A patient with duodenal ulcer and primary hyperparathyroidism was found to have an abnormally high intragastric pH. The pH level returned to normal after surgical removal of the parathyroid adenoma followed by normalization of parathyroid hormone (PTH) and serum calcium concentrations. The patient was positive for Helicobacter pylon (H. pylori) infection. Although the exact mechanism by which chronic hypercalcemia or high PTH level inhibited gastric acid secretion in this case remains unclear, our findings suggest that hypercalcemia may play some role in H. pylori associated gastroduodenal diseases through induction of proinflammatory cytokines or by enhancing the attachment of H. pylori to gastric epithelial cells.
authors.affiliation: Second Department of Internal Medicine, Shimane Medical University, Izumo.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.forename: Keiko
authors.initials: K
authors.lastname: Abe
authors.forename: Naoki
authors.initials: N
authors.lastname: Oshima
authors.forename: Kousaku
authors.initials: K
authors.lastname: Kawashima
authors.forename: Naoharu
authors.initials: N
authors.lastname: Hamamoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Moritani
authors.forename: Rumi
authors.initials: R
authors.lastname: Mak
authors.forename: Shunji
authors.initials: S
authors.lastname: Ishihara
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Adachi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kawauchi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000236:Adenoma / Q000473:pathology / Q000601:surgery; D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001562:Benzimidazoles / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000150:complications* / Q000382:microbiology; D015738:Famotidine / Q000627:therapeutic use; D005745:Gastric Acidity Determination; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006961:Hyperparathyroidism / Q000150:complications* / Q000382:microbiology; D008297:Male; D009853:Omeprazole / Q000031:analogs & derivatives; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000473:pathology / Q000601:surgery; D016105:Parathyroidectomy / Q000379:methods; D064750:Rabeprazole
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D010281:Parathyroid Hormone; D064750:Rabeprazole; D015738:Famotidine; D009853:Omeprazole