title: Chemopreventive effects of emodin and cassiamin B in mouse skin carcinogenesis.
abstract: In continuation of our works of natural and synthetic products as cancer chemopreventive agents, we have examined emodin and cassiamin B, which were isolated from Cassia siamea. These compounds exhibited the remarkable anti-tumor promoting effect on two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter by both topical application. Furthermore, emodin exhibited potent inhibitory activity on two-stage carcinogenesis test of mouse skin tumors induced by nitric oxide donor, (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexeneamide as an initiator and TPA as a promoter.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Higashinada, Kobe 658, Japan. j-koyama@kobepharma-u.ac.jp
authors.forename: Junko
authors.initials: J
authors.lastname: Koyama
authors.forename: Izumi
authors.initials: I
authors.lastname: Morita
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Tagahara
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nobukuni
authors.forename: Teruo
authors.initials: T
authors.lastname: Mukainaka
authors.forename: Masashi
authors.initials: M
authors.lastname: Kuchide
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology*; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002366:Cassia; D004642:Emodin / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate; D013997:Time Factors
chemical_list: D000880:Anthraquinones; D016588:Anticarcinogenic Agents; D004791:Enzyme Inhibitors; C465122:cassiamin B; D015127:9,10-Dimethyl-1,2-benzanthracene; D004642:Emodin; D013755:Tetradecanoylphorbol Acetate