title: Assessing the risk of multiple gestation in gonadotropin intrauterine insemination cycles.
abstract: OBJECTIVE
  The purpose of this study was to analyze factors for their ability to predict multiple gestation in women who undergo controlled ovarian hyperstimulation with gonadotropins (follicle-stimulating hormone/human menopausal gonadotropin) and intrauterine insemination.
  
  
  METHODS
  This was a retrospective analysis of the clinical and laboratory variables that are associated with multiple gestation. Data for 6 variables in 678 cycles of gonadotropin/intrauterine insemination between 1990 and 1999 were analyzed with survival analysis, Cox regression analysis, and multiple logistic regression.
  
  
  RESULTS
  There were 99 clinical pregnancies among 678 cycles (14.6% per cycle) in 306 women. Of the 14 women with multiple gestations (14.1% of pregnancies), 11 women had twins, 2 women had triplets, and 1 woman had quadruplets. Age, days of gonadotropin treatment, total dose of gonadotropin, and number of follicles that were >or=15 mm at the time of human chorionic gonadotropin administration were statistically significant predictors of multiple gestation in >or=1 of the statistical models.
  
  
  CONCLUSIONS
  The risk of multiple gestation with controlled ovarian hyperstimulation/intrauterine insemination in this study was relatively low. In addition to age, several controllable variables that are associated with multiple gestation were identified.
authors.affiliation: Fertility Center at Women's Care, Eugene, Ore., USA.
authors.forename: Paul F
authors.initials: PF
authors.lastname: Kaplan
authors.forename: Misha
authors.initials: M
authors.lastname: Patel
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Austin
authors.forename: Richard
authors.initials: R
authors.lastname: Freund
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D005544:Forecasting; D006801:Humans; D007317:Insemination, Artificial, Homologous; D008596:Menotropins / Q000627:therapeutic use*; D006080:Ovarian Follicle / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D011272:Pregnancy, Multiple; D011336:Probability; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis
chemical_list: D006063:Chorionic Gonadotropin; D008596:Menotropins; D005640:Follicle Stimulating Hormone