Physio-mitotic theory and a new concept of cancer development.
In the physio-mitotic theory, general mitosis consists of two different types: maturation and duplication. While being co-regulated by mechanisms involving maturation and duplication factors, these two types of mitotic activities each play a respective role in the antagonistic histological development of the other. According to the theory of systematic organization, each type of organic tissue is always developed and established under certain physiological conditions. As an organoid tissue, cancerous tissue must also fundamentally develop according to that theory. Consequently, a new concept of cancer development should be devised based on the physio-mitotic theory.
Hirata
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Y
Hirata Hospital, Kochi, Japan.
Hirata
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S
D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology; D008938:Mitosis; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology