Nocturnal enuresis.
OBJECTIVE
The purpose of this review is to highlight and comment upon important areas of enuresis research.


RESULTS
Current areas of pathophysiological focus are nocturnal urine production, in which alternative mechanisms other than deficient vasopressin secretion has been implicated in some patients. Bladder reservoir function has gained renewed interest, and has proved to be one of the best predictors of treatment response to desmopressin. Various aspects of central nervous system function, including arousability and pontine reflexes, are in focus, and molecular genetics has provided firm evidence of a link between enuresis and different chromosomal markers. The therapeutic focus is directed towards a differential approach based upon the underlying mechanism and towards combination therapies such as alarm devices and desmopressin as well as anticholinergic agents and desmopressin. Furthermore, new exciting treatment concepts such as laser acupuncture have shown promising results in initial studies.


CONCLUSIONS
Despite recent advances in our understanding of nocturnal enuresis, we are still far from understanding in detail this socially discomfiting and scientifically intriguing condition, and many controversies remain. However, the substantiation that enuresis is a heterogeneous condition that requires a differential approach has provided the basis for further progress.
Djurhuus
Jens C
JC
Institute of Experimental Clinical Research, Aarhus University Hospital, Skejby Section, Denmark. jcd@iekf.au.dk
Rittig
Søren
S
D001127:Arginine Vasopressin / Q000378:metabolism; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D004775:Enuresis / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D006801:Humans; D001743:Urinary Bladder / Q000503:physiopathology; D014563:Urodynamics
D001127:Arginine Vasopressin; D003894:Deamino Arginine Vasopressin