Cardiac specific expression of Xenopus Popeye-1.
Popeye genes code for putative transmembrane proteins that are predominantly expressed in heart and skeletal muscle. Here we report on the isolation and expression of a previously unknown Xenopus member of this family, Xenopus Popeye-1 (Xpop-1). Xpop-1 is 60-65% identical to other vertebrate Pop-1 genes at the protein level. Whole-mount in situ hybridization studies revealed a highly specific expression of Xpop-1 whose transcripts are restricted to the embryonic heart and become enriched in the forming ventricle. Interestingly, unlike other known vertebrate Popeye genes, Xpop-1 is exclusively expressed in cardiac tissue and absent from skeletal muscle.
Hitz
Marc P
MP
Abt. Entwicklungsbiochemie, Junior Group SFB 271, Universität Göttingen, Humboldtallee 23, 37073 Göttingen, Germany.
Pandur
Petra
P
Brand
Thomas
T
Kühl
Michael
M
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015815:Cell Adhesion Molecules; D018076:DNA, Complementary; D015870:Gene Expression; D006321:Heart / Q000196:embryology*; D006801:Humans; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics*; D009206:Myocardium / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D029867:Xenopus Proteins / Q000235:genetics*; D014982:Xenopus laevis / Q000196:embryology / Q000235:genetics*
C470297:Bves protein, Xenopus; D015815:Cell Adhesion Molecules; D018076:DNA, Complementary; D009124:Muscle Proteins; D029867:Xenopus Proteins