title: [Hysteroscopic ablation of the endometrium in cases of dysfunctional uterine bleeding--advantage of preparations including zoladex].
abstract: Hysteroscopic endometrial ablation (HEA) is a new alternative for patients with dysfunctional uterine bleeding (DUB), resistant to medical treatment. The relatively thin endometrium is a big advantage at the time of operation. In this article the results of an initial series of hysteroscopic operations (HEA) are given--as a whole and depending on preoperative treatment with GnRH-agonist. Seventeen patients with DUB underwent HEA. Six of them were pretreated with Goserelin acetate (Zoladex 3.6 mg, Astra Zeneca) two subcutaneous application at 28 days interval. The other 11 women were operated in the early postmenstrual period without medical pretreatment. Comparison was made between the two groups regarding preoperative endometrial thickness, operative time, operative complications, duration of hospital stay, change of the menstrual pattern after 6 and 12 months. Results showed 41.2% achievement of persistent amenorrhoea in patients as a whole (62.7% in the Zoladex group and 27.2% in the untreated group). Better results in the patients with Zoladex pretreatment (shorter operative time, higher incidence of amenorrhoea, patient's higher evaluation of the operation) can be explained with the reduced endometrial thickness at the time procedure. The authors consider the hysteroscopic roller-ball endometrial ablation as an upto-date cost-effective method for treatment of DUB. The method is quick, with very low incidence of complications, easy toleration, immediately recovery of the patient and the only possibility for women with high anaesthesiologic and operative risk. Two depot-doses of Zoladex before hysteroscopy lead to better intra- and postoperative results.
authors.forename: E
authors.initials: E
authors.lastname: Tiufekchieva
authors.forename: A
authors.initials: A
authors.lastname: Nikolov
mesh_terms: D000328:Adult; D004334:Drug Administration Schedule; D004717:Endometrium / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D017273:Goserelin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015907:Hysteroscopy / Q000191:economics / Q000379:methods* / Q000706:statistics & numerical data; D007279:Injections, Subcutaneous; D007902:Length of Stay; D008875:Middle Aged; D011292:Premedication; D016896:Treatment Outcome; D014592:Uterine Hemorrhage / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*
chemical_list: D017273:Goserelin
vernacular_title: Khisteroskopska ablatsiia na endometriuma pri disfunktsionalni matochni krŭvotechniia--predimstva na podgotovkata sŭs Zoladeks.