title: Variability in cholesteryl ester transfer protein in healthy Japanese hyper-HDL-cholesterolemic subjects.
abstract: OBJECTIVE
  Hyper-high density lipoprotein (HDL)-cholesterolemia has been considered to be anti-atherogenic and is referred to as longevity syndrome. However, hyper-HDL-cholesterolemia induced by a cholesteryl ester transfer protein (CETP) deficiency may not be athero-protective, rather being atherogenic in nature. In a rural area in central Japan, the incidence of hyper-HDL-cholesterolemia has been found to be rather high (3.1% of healthy people). We studied healthy Japanese people in this area with hyper-HDL-cholesterolemia, particularly in relation to CETP.
  
  
  METHODS
  Serum lipids were analyzed, and CETP mass was determined with an enzyme immunoassay method.
  
  
  METHODS
  Blood was drawn after an overnight fast from 17 Japanese (5 males and 12 females) with serum HDL-cholesterol (C) > or =100 mg/dl.
  
  
  RESULTS
  Serum CETP mass in hyper-HDL-cholesterolemic subjects was distributed in a wide range. Serum CETP mass was positively correlated with low-density lipoprotein (LDL)-C, apolipoprotein (Apo) B, and LDL-C/HDL-C, with statistical significance. CETP was also positively correlated with LDL-C/Apo B.
  
  
  CONCLUSIONS
  These results suggest that hyper-HDL-cholesterolemia may not be a single clinical entity, but a mixture of various pathophysiological conditions, and that the ratio of LDL-C to HDL-C and the size of LDL may be important factors in classifying these conditions.
authors.affiliation: Department of Clinical Laboratory, Nakatsugawa Municipal Hospital.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yoshida
authors.forename: Michiteru
authors.initials: M
authors.lastname: Kodama
authors.forename: Hideki
authors.initials: H
authors.lastname: Nomura
authors.forename: Norifumi
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Sumida
authors.forename: Michitaka
authors.initials: M
authors.lastname: Naito
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001055:Apolipoproteins B / Q000097:blood; D002352:Carrier Proteins / Q000097:blood*; D053480:Cholesterol Ester Transfer Proteins; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006023:Glycoproteins; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D007564:Japan; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D001055:Apolipoproteins B; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008078:Cholesterol, LDL; D006023:Glycoproteins; D008075:Lipoproteins, HDL