Influencing factors of pancreatic microcirculatory impairment in acute panceatitis.
Pancreatic microcirculatory disturbance plays an important role in th e pathogenesis of acute pancreatitis, and it involves a series of changes including vasoconstriction, ischaemia, increased vascular permeability, impairment of nutritive tissue perfusion, ischaemia/reperfusion, leukocyte adherence, hemorrheological changes and impaired lymphatic drainage. Ischaemia possibly acts as an initiating factor of pancreatic microcirculatory injury in acute pancreatitis, or as an aggravating/continuing mechanism. The end-artery feature of the intralobular arterioles suggests that the pancreatic microcirculation is highly susceptible to ischaemia. Various vasoactive mediators, as bradykinin, platelet activating factor, endothelin and nitric oxide participate in the development of microcirculatory failure.
Zhou
Zong-Guang
ZG
Department of Hepato-bilio-pancreatic Surgery & Institute of Microcirculation, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. 258836@mail.guoli.com.cn
Chen
You-Dai
YD
D000208:Acute Disease; D001920:Bradykinin / Q000502:physiology; D002199:Capillary Permeability; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology; D016232:Endothelins / Q000502:physiology; D018056:Hemorheology; D006801:Humans; D007511:Ischemia / Q000503:physiopathology; D007962:Leukocytes / Q000502:physiology; D008833:Microcirculation / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology; D010179:Pancreas / Q000098:blood supply; D010195:Pancreatitis / Q000209:etiology / Q000503:physiopathology*; D010972:Platelet Activating Factor / Q000502:physiology; D014661:Vasoconstriction
D015815:Cell Adhesion Molecules; D016232:Endothelins; D010972:Platelet Activating Factor; D009569:Nitric Oxide; D001920:Bradykinin