title: Identification of swainsonine as a glycoside inhibitor responsible for Sida carpinifolia poisoning.
abstract: The indolizidine alkaloid swainsonine has been identified as the toxic constituent of Sida carpinifolia, a native perennial shrub-like plant, reported to produce neurological disorders in goats and ponies in southern Brazil. Swainsonine was detected in dry ground plant material after extraction and analysis by both liquid and gas chromatography mass spectrometry. The swainsonine concentration was 0.006% on a dry weight basis. The clinical and pathological features of this lysosomal storage disease were similar to those observed in Swainsona, Oxytropis, Astragalus, and Ipomoea poisonings with multiple cytoplasm vacuoles in neurons, acinar pancreatic cells, hepatocytes, and renal tubular cells.
authors.affiliation: Department of Veterinary Pathology, FUFMT, Mato Grosso, Brazil.
authors.forename: Edson Moleta
authors.initials: EM
authors.lastname: Colodel
authors.forename: Dale R
authors.initials: DR
authors.lastname: Gardner
authors.forename: Priscila
authors.initials: P
authors.lastname: Zlotowski
authors.forename: David
authors.initials: D
authors.lastname: Driemeier
mesh_terms: D000818:Animals; D001938:Brazil; D004791:Enzyme Inhibitors / Q000032:analysis* / Q000506:poisoning; D008401:Gas Chromatography-Mass Spectrometry; D006734:Horse Diseases / Q000139:chemically induced; D006736:Horses; D019660:Malvaceae / Q000737:chemistry* / Q000506:poisoning; D010939:Plant Poisoning / Q000209:etiology / Q000662:veterinary; D017026:Swainsonine / Q000032:analysis* / Q000506:poisoning
chemical_list: D004791:Enzyme Inhibitors; D017026:Swainsonine