Antithrombotic effect of onion in streptozotocin-induced diabetic rat.
In the present study, we investigated whether onion has antithrombotic effect in streptozotocin (STZ)-induced diabetic rats. In diabetic rats, serum thromboxane B(2) (TXB(2)) level was elevated compared to that in normal, and this elevation in diabetes was significantly inhibited by treatment with onion (0.5 g/ml/kg/day, i.p.) for 4 weeks. In normal rats, the serum TXB(2) level remained unaltered after the treatment with onion. To investigate in vitro effect of onion, we examined its effect on TXB(2) formation, platelet aggregation and arachidonic acid (AA)-release in platelets from diabetic and normal rats. Onion showed a significant inhibitory effect on collagen- or AA-induced TXB(2) formation with greater potency in diabetic platelets than in normal. Similarly, more potent inhibitory effects of onion in diabetes were observed in collagen- or AA-induced platelet aggregation and collagen-induced AA release response. In conclusion, these results suggest that onion can produce more beneficial antithrombotic effect in diabetes.
Jung
Yi-Sook
YS
Department of Physiology, School of Medicine, Ajou University, Paldal-gu, Suwon, South Korea.
Kim
Min Hwa
MH
Lee
Soo Hwan
SH
Baik
Eun Joo
EJ
Park
Se Won
SW
Moon
Chang-Hyun
CH
D000818:Animals; D000991:Antithrombins / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D019697:Onions; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000494:pharmacology; D013929:Thromboxane B2 / Q000096:biosynthesis / Q000097:blood
D000991:Antithrombins; D001095:Arachidonic Acids; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D013929:Thromboxane B2; D013311:Streptozocin; D007770:L-Lactate Dehydrogenase