title: Inhibition of monoADP-ribosylation prevents long-term memory consolidation of a single-trial passive avoidance task in the day-old chick.
abstract: The cytosolic posttranslational protein-modifying mechanism of monoADP-ribosylation has been implicated in long-term potentiation, a synaptic model of memory formation. The current study investigated the effect of inhibiting mono(ADP-ribosyl) transferase on memory for the passive avoidance task in day-old chicks (white Leghorn-black Australorp). Various doses of novobiocin or menadione sodium bisulfite were administered intracranially at different times before or after training. Control chicks were administered saline at matched times. Novobiocin (650 microM) or menadione sodium bisulfite (250 microM) administered between 5.0 min pretraining and 2.5 min posttraining was found to cause a persistent loss of retention from 120 min posttraining. These data provide the first demonstration that monoADP-ribosylation is required for the maintenance of long-term memory. Furthermore, the temporal characteristics of the memory loss caused by monoADP-ribosylation inhibition appears to exclude this mechanism as a downstream effect of the well-established nitric oxide activity previously shown to occur within 40 min of passive avoidance training.
authors.affiliation: Department of Psychology, Monash University, Victoria, 3800, Australia.
authors.forename: T M
authors.initials: TM
authors.lastname: Edwards
authors.forename: N S
authors.initials: NS
authors.lastname: Rickard
mesh_terms: D036002:ADP Ribose Transferases; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002645:Chickens; D008568:Memory / Q000187:drug effects*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D012153:Retention, Psychology / Q000187:drug effects; D013997:Time Factors
chemical_list: D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D036002:ADP Ribose Transferases