Lymphatic mapping in solid neoplasms: state of the art.
BACKGROUND
Lymphatic mapping and sentinel lymph node biopsy is an established technique for the staging and treatment of melanoma. The success of lymphatic mapping in this realm has broadened its application to other solid neoplasms. This update reviews the status of sentinel lymph node biopsy in its most widely cited applications.


METHODS
Seminal manuscripts on lymphatic mapping in melanoma, breast, colon, vulvar, cervical, lung, gastric, and head and neck cancers are reviewed.


RESULTS
Studies suggest that the application of lymphatic mapping as a staging tool in breast cancer and melanoma is justified when applied by trained surgeons. Additional validation is necessary before sentinel node biopsy is advocated in gynecologic, colon, lung, and head and neck cancer.


CONCLUSIONS
As in breast cancer and melanoma, validation of the sentinel node concept in other solid tumors must occur in institutions other than those in which the technique is being developed before it is generally applied to other neoplasms.
Zervos
Emmanuel E
EE
Department of Clinical Investigations, H. Lee Moffitt Cancer Center & Research Institute, University of South Florida, Tampa, FL 33612, USA. zervosee@moffitt.usf.edu
Burak
William E
WE
D001943:Breast Neoplasms / Q000473:pathology; D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D008545:Melanoma / Q000473:pathology; D018579:Patient Selection; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*