Hemodynamic state and the role of angiotensin II in ovarian hyperstimulation syndrome in the rabbit.
OBJECTIVE
To investigate the hemodynamic state in the ovarian hyperstimulation syndrome (OHSS) in the rabbit model and to determine the role of angiotensin II in the pathophysiology of this syndrome.


METHODS
Experimental study.


METHODS
Physiology laboratory.


METHODS
Female New Zealand rabbits were studied; 16 rabbits were stimulated with gonadotropins, and 6 were controls. Six of the stimulated rabbits received additional treatment with captopril.


METHODS
Cardiac index, blood pressure, and heart rate were recorded.


RESULTS
Gonadotropin-stimulated rabbits had significant enlargement of ovaries that was not modified by captopril. Ascites was present in 80% of animals in the OHSS group; captopril significantly decreased the incidence and volume of ascites. The three groups did not differ in blood pressure, heart rate, cardiac index, and total peripheral resistance.


CONCLUSIONS
In rabbits with OHSS, ascites are a primary event. Such animals are normotensive and have normal vascular resistance and cardiac index. Angiotensin-converting enzyme inhibition decreases the incidence of OHSS in the rabbit model by 30%, suggesting that angiotensin II may play a role in the formation of ascites.
Teruel
Maria Jose G
MJ
Departmento de Fisiología de la Universidad de Murcia, Murcia, Spain.
Carbonell
Luis F
LF
Llanos
Maria Carmen
MC
Parrilla
Juan J
JJ
Abad
Lorenzo
L
Hernandez
Isabel
I
D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001201:Ascites / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D008596:Menotropins / Q000494:pharmacology; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced / Q000503:physiopathology*; D010053:Ovary / Q000187:drug effects / Q000473:pathology; D011817:Rabbits
D006063:Chorionic Gonadotropin; D000804:Angiotensin II; D008596:Menotropins