[Estimation of the recombination fraction by the maximum likelihood method in mapping interacting genes relative to marker loci].
For mapping nonlinked interacting genes relative to marker loci, the recombination fractions can be calculated by using the log-likelihood functions were derived that permit estimation of recombinant fractions by solving the ML equations on the basis of F2 data at various types of interaction. In some cases, the recombinant fraction estimates are obtained in the analytical form while in others they are numerically calculated from concrete experimental data. With the same type of epistasis the log-functions were shown to differ depending on the functional role (suppression or epistasis) of the mapped gene. Methods for testing the correspondence of the model and the recombination fraction estimates to the experimental data are discussed. In ambiguous cases, analysis of the linked marker behavior makes it possible to differentiate gene interaction from distorted single-locus segregation, which at some forms of interaction imitate phenotypic ratios.
Priiatkina
S N
SN
Department of Genetics and Breeding, St. Petersburg State University, St. Petersburg, 199034 Russia. sofia@sp1254.spb.edu
D002874:Chromosome Mapping / Q000379:methods*; D005799:Genes, Dominant; D005819:Genetic Markers; D005828:Genetics, Population; D016013:Likelihood Functions; D008957:Models, Genetic; D010641:Phenotype; D011995:Recombination, Genetic
D005819:Genetic Markers
Ispol'zovanie metoda maksimal'nogo pravdopodobiia dlia otsenki chastoty rekombinatsii pri kartirovanii vzaimodeĭstvuiushchikh genov otnositel'no markernykh lokusov.