Fibrinogen binding to intercellular adhesion molecule 1: implications for Plasmodium falciparum adhesion.
Intercellular adhesion molecule 1 (ICAM-1) is an endothelial cell adhesion molecule implicated in cerebral malaria. We investigated whether fibrinogen affects Plasmodium falciparum binding to ICAM-1, as the ICAM-1 binding sites of P. falciparum and fibrinogen overlap. We show that fibrinogen dramatically reduces P. falciparum adhesion to ICAM-1 under flow conditions.
Gray
Carolyn
C
Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.
Craig
Alister
A
D000818:Animals; D004912:Erythrocytes / Q000469:parasitology; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000378:metabolism* / Q000502:physiology
D018799:Intercellular Adhesion Molecule-1; D005340:Fibrinogen