title: PI 3-kinases and PTEN: how opposites chemoattract.
abstract: Phosphatidylinositol lipids, such as PI(4,5)P2 and PI(3,4,5)P3, are key mediators in diverse intracellular signaling pathways. Two recent reports examine how the metabolism of these lipids by phosphatidylinositol 3-kinases and the PTEN 3-phosphoinositide phosphatase may coordinate G protein coupled signaling pathways during eukaryotic chemotaxis.
authors.affiliation: PRAT Research Fellowship Program, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Frank I
authors.initials: FI
authors.lastname: Comer
authors.forename: Carole A
authors.initials: CA
authors.lastname: Parent
mesh_terms: D000818:Animals; D016764:Cell Polarity / Q000502:physiology; D002633:Chemotaxis / Q000502:physiology*; D004023:Dictyostelium / Q000166:cytology / Q000378:metabolism; D005057:Eukaryotic Cells / Q000166:cytology / Q000201:enzymology*; D006801:Humans; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D010716:Phosphatidylinositols; D025521:Tumor Suppressor Proteins; D019869:Phosphatidylinositol 3-Kinases; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human