title: Primary malignant melanoma of the male urethra.
abstract: We report a case of primary malignant melanoma of the male urethra in a patient whose penile shaft was successfully preserved, but who proceeded to acute renal failure (ARF) after interferon (IFN)-beta adjuvant immunotherapy. Primary malignant melanoma of the male urethra is rare and usually shows highly malignant potential. Therefore, urologists must often perform phallectomy, which impacts on the patient both sexually and mentally. A 64-year-old man presented at Saiseikai Sendai Hospital with asymptomatic gross hematuria and was diagnosed as distal urethral tumor. We predicted the highly malignant potential of this tumor from the urethroscopic finding and from urinary cytological examination. We did not select trans-urethral resection (TUR), but selected partial urethrectomy. This patient proceeded to ARF 1 month after natural IFN-beta treatment as an adjuvant immunotherapy. As IFN-beta rarely induces the delayed renal failure, urologists should be aware of renal dysfunction after IFN-beta therapy for the treatment of malignant melanoma.
authors.affiliation: Department of Urology, Faculty of Medicine, Kagoshima University, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kubo
authors.forename: Itaru
authors.initials: I
authors.lastname: Miyawaki
authors.forename: Mari
authors.initials: M
authors.lastname: Kawagoe
authors.forename: Kazumi
authors.initials: K
authors.lastname: Kuriwaki
authors.forename: Shingo
authors.initials: S
authors.lastname: Hatanaka
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakagawa
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced; D000970:Antineoplastic Agents / Q000009:adverse effects; D001706:Biopsy; D006801:Humans; D016899:Interferon-beta / Q000009:adverse effects; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology*; D008875:Middle Aged; D014523:Urethral Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D016899:Interferon-beta