Application of 1,3-dibromo-5,5-dimethylhydantoin (DBH) instead of bromine gas or bromine water decolorization for drug identification according to PH. EUR. Analytical methods of pharmacopoeias with DBH in respect to environmental and economical concern, Part 14.
PH. EUR. 2002 identifies biotin, flucytosine, polysorbate 80 and sorbic acid using the decolorization of bromine water. These tests can be better performed with 1,3-dibromo-5,5-dimethylhydantoin (DBH) in combination of the reaction with fluorescein sodium resp. sodium bromide. Also fluorescein sodium PH. EUR. Suppl 2002 can be identified with DBH.
Hilp
M
M
Institut für Pharmazeutische Chemie, Philipps-Universität, Marburg, Germany. Hilp@mailer.uni-marburg.de
D001710:Biotin / Q000737:chemistry; D001966:Bromine / Q000737:chemistry* / Q000191:economics; D002936:Cinnarizine / Q000737:chemistry; D004787:Environmental Pollution; D005060:Europe; D005437:Flucytosine / Q000737:chemistry; D019793:Fluorescein / Q000737:chemistry; D006827:Hydantoins / Q000737:chemistry* / Q000191:economics; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations / Q000032:analysis*; D010602:Pharmacopoeias as Topic; D011136:Polysorbates / Q000737:chemistry; D013011:Sorbic Acid / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
D006827:Hydantoins; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D011136:Polysorbates; D002936:Cinnarizine; D001710:Biotin; D005437:Flucytosine; D001966:Bromine; D019793:Fluorescein; C056578:1,3-dibromo-5,5-dimethylhydantoin; D013011:Sorbic Acid