First total synthesis of A(2) isoprostane.
A stereoselective Julia-Lythgoe olefination has allowed the first total synthesis of A(2) isoprostane (1), a recently discovered member of the growing isoprostane family. This elusive compound opens up numerous new avenues for the molecular biology of cyclopentenone prostaglandins, which are endowed of intriguing biological effects such as antitumor, antiinflammatory, and antiviral activities.
Zanoni
Giuseppe
G
Department of Organic Chemistry, University of Pavia, Viale Taramelli, 10, 27100, Italy. gzanoni@unipv.it
Porta
Alessio
A
Vidari
Giovanni
G
D000475:Alkenes / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D028421:Isoprostanes / Q000138:chemical synthesis* / Q000145:classification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure
C466067:A(2) isoprostane; D000475:Alkenes; D028421:Isoprostanes