title: Protein-interaction networks: from experiments to analysis.
abstract: Functional proteomics approaches aim to characterize comprehensively the function of gene products, and provide a first-level understanding of cellular mechanisms. Here, we review recent techniques for the construction and prediction of large-scale protein-interaction networks, with a particular emphasis on computational processing steps and comparative assessment of the reliability and completeness of the various approaches. We also discuss the use of protein-interaction network information in functional annotation and in the generation of higher-level biological hypotheses on pathways.
authors.affiliation: Hybrigenics, 3-5 Impasse Reille, Paris 75014, France. vschachter@hybrigenics.fr
authors.forename: Vincent
authors.initials: V
authors.lastname: Schächter
mesh_terms: D019295:Computational Biology / Q000379:methods*; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D015398:Signal Transduction
chemical_list: D011506:Proteins