Confirmation of association between D10S583 and Alzheimer's disease in a case--control sample.
Several independent studies have reported that loci on chromosome 10 are associated/linked with Alzheimer's disease (AD), including a family-based study demonstrating an association between the marker D10S583 and AD. We have examined the D10S583 polymorphic marker and apolipoprotein E (APOE) gene in a case-control study. We observed the expected association of the APOE allele varepsilon4 with AD, and an inverse association between the D10S583 allele 209 and AD. These data support the original findings that suggest the presence of a candidate gene for AD in this region of chromosome 10. The nearby insulin degrading enzyme gene has been previously proposed as a candidate gene; however, a number of other putative candidate genes are also located in this region. The ongoing investigation of the genetic source of association and linkage in this region is clearly warranted.
Ait-Ghezala
G
G
Roskamp Institute, University of South Florida, 3515 E. Fletcher Avenue, Tampa, FL 33613, USA. gaitghel@hsc.usf.edu
Abdullah
L
L
Crescentini
R
R
Crawford
F
F
Town
T
T
Singh
S
S
Richards
D
D
Duara
R
R
Mullan
M
M
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D018900:Dinucleotide Repeats; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D005819:Genetic Markers