title: Is glucagonoma of the pancreas a curable disease?
abstract: BACKGROUND
  Glucagonomas are rare neuroendocrine tumors of the pancreas. Because of its rarity, its natural history is not well understood.
  
  
  OBJECTIVE
  We evaluated the natural history of glucagonomas treated at a tertiary care cancer center.
  
  
  METHODS
  A retrospective analysis of 12 patients during 1970 to 2000 was performed. Six patients (50%) had a tumor located in the head of the pancreas.
  
  
  RESULTS
  Abdominal pain (83%) and weight loss (75%) were the most common symptoms. Median tumor size was 6 cm (range 0.04-10). Seven patients (58%) had liver metastases. Five patients (42%) underwent curative resection. Overall median survival was 66 mo, and 5-yr overall survival was 66%. Five-yr overall survival was 83% for patients who had resection versus 50% for the non-resected patients (p = 0.04). Patients who were disease-free had a complete resection of the primary tumor and no liver involvement.
  
  
  CONCLUSIONS
  Glucagonomas generally present with liver metastases at the time of diagnosis. Cure is only possible if the disease is localized and completely resected.
authors.affiliation: Department of Surgical Oncology, Roswell Park Cancer Institute, State University of New York at Buffalo, 14263-0001, USA.
authors.forename: Q D
authors.initials: QD
authors.lastname: Chu
authors.forename: M F
authors.initials: MF
authors.lastname: Al-kasspooles
authors.forename: J L
authors.initials: JL
authors.lastname: Smith
authors.forename: H R
authors.initials: HR
authors.lastname: Nava
authors.forename: H O
authors.initials: HO
authors.lastname: Douglass
authors.forename: D
authors.initials: D
authors.lastname: Driscoll
authors.forename: J F
authors.initials: JF
authors.lastname: Gibbs
mesh_terms: D000328:Adult; D000368:Aged; D000713:Anastomosis, Roux-en-Y; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002779:Cholestasis / Q000601:surgery; D004621:Embolization, Therapeutic; D005260:Female; D005935:Glucagonoma / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents