Interleukin 17: an example for gene therapy as a tool to study cytokine mediated regulation of hematopoiesis.
Interleukin 17 (IL-17) is an essential proinflammatory T-cell derived cytokine with various biological actions. IL-17 was found to have a pivotal role in microbial host defense by interconnecting lymphoid and myeloid host defense. It also acts as a stimulatory hematopoietic cytokine by expanding myeloid progenitors and initiating proliferation of mature neutrophils. This article summarizes results to date on IL-17 research and discusses gene therapy based strategies that were employed to determine its biological functions and significance. A comprehensive working model for IL-17 is introduced.
Schwarzenberger
Paul
P
Gene Therapy Program, Louisiana State University Health Sciences Center of New Orleans, 70112, USA. pschwa1@lsuhsc.edu
Kolls
Jay K
JK
D000818:Animals; D004195:Disease Models, Animal; D015316:Genetic Therapy / Q000379:methods*; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D007710:Klebsiella Infections / Q000276:immunology; D018375:Neutrophil Activation / Q000187:drug effects; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D020381:Interleukin-17