title: Indocyanine green angiographic findings in acute retinal necrosis.
abstract: OBJECTIVE
  To clarify indocyanine green (IA) angiographic features in patients with acute retinal necrosis (ARN).
  
  
  METHODS
  Two patients with ARN were examined by fluorescein angiography (FA) and IA, and findings from both were compared.
  
  
  RESULTS
  Fundus examination revealed widespread retinal hemorrhages and yellowish-white patches in the periphery, characteristic of ARN. In both cases, FA showed diffuse dye leakage from all retinal veins and the optic disc, and vascular obstruction in the peripheral fundus. In IA, dye leakage was localized, and extravasation of dye was evident only from the lower temporal retinal vein and the lower half of the optic disc. This pattern of indocyanine green dye leakage appeared to be continuous from the optic disc toward the lower temporal retinal vein. Also, IA clearly demonstrated choroidal vascular filling delay in one case in the early phase of the angiogram.
  
  
  CONCLUSIONS
  While FA showed diffuse dye leakage from all retinal veins, IA identified only the retinal vessels with the most prominent vascular damage. IA also identified choroidal vascular lesions in these patients with ARN. The information obtained by IA might be useful to detect retinal vasculitis with prominent inflammation and to determine the extent of choroidal inflammation in patients with ARN.
authors.affiliation: Department of Ophthalmology and Visual Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Hisayo
authors.initials: H
authors.lastname: Takei
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ohno-Matsui
authors.forename: Masato
authors.initials: M
authors.lastname: Hayano
authors.forename: Manabu
authors.initials: M
authors.lastname: Mochizuki
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D004396:Coloring Agents; D004279:DNA, Viral / Q000032:analysis; D005451:Fluorescein Angiography / Q000379:methods*; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000627:therapeutic use; D006561:Herpes Simplex / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology; D006563:Herpes Zoster Ophthalmicus / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology; D018258:Herpesvirus 2, Human / Q000235:genetics / Q000302:isolation & purification; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D015882:Retinal Necrosis Syndrome, Acute / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D012171:Retinal Vessels / Q000473:pathology*
chemical_list: D000998:Antiviral Agents; D004396:Coloring Agents; D004279:DNA, Viral; D005938:Glucocorticoids; D011239:Prednisolone; D007208:Indocyanine Green; D000212:Acyclovir