ms1, a novel stress-responsive, muscle-specific gene that is up-regulated in the early stages of pressure overload-induced left ventricular hypertrophy.
We have identified and characterised a cDNA encoding a novel gene, designated myocyte stress 1 (ms1), that is up-regulated within 1 h in the left ventricle following the application of pressure overload by aortic banding in the rat. The deduced ms1 protein of 317 amino acids contains several putative functional motifs, including a region that is evolutionarily conserved. Distribution analysis indicates that rat ms1 mRNA expression is predominantly expressed in striated muscle and progressively increases in the left ventricle from embryo to adulthood. These findings suggest that ms1 may be important in striated muscle biology and the development of pressure-induced left ventricular hypertrophy.
Mahadeva
Harin
H
Division of Cardiology, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, UK. hm11@leicester.ac.uk
Brooks
Gavin
G
Lodwick
David
D
Chong
Nelson W
NW
Samani
Nilesh J
NJ
D000595:Amino Acid Sequence; D000818:Animals; D001011:Aorta; D001483:Base Sequence; D001794:Blood Pressure; D002874:Chromosome Mapping; D018076:DNA, Complementary; D006352:Heart Ventricles / Q000378:metabolism; D017379:Hypertrophy, Left Ventricular / Q000378:metabolism*; D008297:Male; D008840:Microfilament Proteins; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics*; D009206:Myocardium / Q000378:metabolism*; D012333:RNA, Messenger; D051381:Rats; D011921:Rats, Inbred WKY; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013312:Stress, Physiological; D014018:Tissue Distribution; D015854:Up-Regulation
C461039:Abra protein, rat; D018076:DNA, Complementary; D008840:Microfilament Proteins; D009124:Muscle Proteins; D012333:RNA, Messenger