Effects of antioxidants on kidney disease.
Kidney mesangial cells (MCs) and vascular smooth muscle cells (VSMCs) are closely related in terms of origin, microscopic anatomy, histochemistry, and contractility. This relationship suggests a similarity between kidney glomerular sclerosis and atherosclerosis. Vitamin E appears beneficial in the prevention and treatment of coronary disease and also inhibits the proliferation of VSMCs in vitro. We used vitamin E and probucol to treat glomerular sclerosis and MC-proliferative glomerulonephritis (GN) in two animal models of glomerular disease. Using rats, a remnant kidney model accelerated with hyperlipidemia was employed to reflect progressive glomerular sclerosis leading to chronic renal failure, and an anti-thymocyte serum treatment was used to model acute MC-proliferative GN. Supplemental dietary antioxidants suppress MC proliferation and glomerular sclerosis in models of glomerular disease in rats. These results suggest that treatment with antioxidants may be a promising intervention to prevent progression of kidney disease.
Mune
Masatoshi
M
Department of Internal Medicine (III), Wakayama Medical College, 811-1 Kimiidera, Wakayama 641-0012, Japan. mmune@wakayama-med.ac.jp
Otani
Haruhisa
H
Yukawa
Susumu
S
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002791:Cholesterol, Dietary / Q000009:adverse effects; D019587:Dietary Supplements; D004195:Disease Models, Animal; D015432:Glomerulonephritis, Membranoproliferative / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D007672:Kidney Cortex / Q000378:metabolism; D008264:Macrophages / Q000166:cytology; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D018800:Thy-1 Antigens / Q000276:immunology; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D002791:Cholesterol, Dietary; D018800:Thy-1 Antigens; D014810:Vitamin E