title: Cleveland clinic CorAide blood pump circulatory support without anticoagulation.
abstract: The Cleveland Clinic CorAide left ventricular assist system consists of a permanently implantable centrifugal pump in which the rotating assembly is completely suspended and noncontacting. A series of chronic animal in vivo studies were conducted to evaluate the biologic effects of CorAide circulatory support without the use of anticoagulation therapy. The CorAide pump was implanted in six calves (five calves for 21 to 32 days and one calf for 95 days). The first five calves received intravenous heparin during the early postoperative periods (2-7 days). Heparin administration was then discontinued and no other anticoagulant drugs were used for the duration of the experiments. The last calf did not receive any anticoagulant except for a bolus dose of heparin (200 U/kg) during surgery. Hemodynamics were stable in all six calves, with a mean pump flow of 5.6+/-1.2 L/min and mean arterial pressure of 100+/-4 mm Hg. The blood pump surfaces were clean of thrombus in all six calves. Significant findings at autopsy were limited to one case of renal infarction. There was no incidence of mechanical failure, bleeding, or device infection. The CorAide pump can be safely run with minimal or no anticoagulant therapy.
authors.affiliation: Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA.
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Ochiai
authors.forename: Leonard A R
authors.initials: LA
authors.lastname: Golding
authors.forename: Alex L
authors.initials: AL
authors.lastname: Massiello
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Medvedev
authors.forename: David J
authors.initials: DJ
authors.lastname: Horvath
authors.forename: Renee L
authors.initials: RL
authors.lastname: Gerhart
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Chen
authors.forename: Alexandra Y
authors.initials: AY
authors.lastname: Krogulecki
authors.forename: Masami
authors.initials: M
authors.lastname: Takagaki
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Doi
authors.forename: Michael W
authors.initials: MW
authors.lastname: Howard
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D002417:Cattle; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006493:Heparin / Q000494:pharmacology; D006801:Humans
chemical_list: D000925:Anticoagulants; D006493:Heparin