N(2)-phenyldeoxyguanosine: modulation of the chemical properties of deoxyguanosine toward one-electron oxidation in DNA.
We have shown here that (1) substitution of an exocyclic amino group of dG is effective in modulating the chemical properties of dG toward one-electron oxidation and (2) decomposition of the guanine radical cation was effectively suppressed near dPhG. These results indicate that dPhG is a prototype of nucleosides functioning as an intrinsic antioxidant of duplex DNA toward one-electron oxidation.
Nakatani
Kazuhiko
K
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, and CREST and PRESTO, Japan Science and Technology Corporation, Kyoto 606-8501, Japan. nakatani@sbchem.kyoto-u.ac.jp
Dohno
Chikara
C
Saito
Isao
I
D001345:Autoradiography; D004247:DNA / Q000737:chemistry*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000737:chemistry*; D010084:Oxidation-Reduction; D010777:Photochemistry
C462100:N(2)-phenyldeoxyguanosine; D004247:DNA; D003849:Deoxyguanosine