Beads of acryloylated polyaminoacidic matrices containing 5-Fluorouracil for drug delivery.
Spherical polymeric microparticles have been prepared by a reverse phase suspension polymerization technique. The starting polymer was alpha,beta-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA), partially derivatized with glycidylmethacrylate (GMA). PHEA-GMA copolymer (PHG) was crosslinked in the presence of N,N'-dimethylacrylamide (DMAA) or N,N'-ethylenebisacrylamide (EBA). 5-fluorouracil was incorporated into PHG-DMAA or PHG-EBA beads both during and after the crosslinking process. Swelling studies revealed a high affinity toward aqueous medium, influenced by the presence of 5-fluorouracil. The in vitro release study showed that the release rate depends on the chemical structure of the beads and the procedure adopted to incorporate 5-fluorouracil into the microparticles.
Pitarresi
G
G
Dipartimento di Chimica e Tecnologie Farmaceutiche, Università di Palermo, Palermo, Italy.
Pierro
P
P
Giammona
G
G
Muzzalupo
R
R
Trombino
S
S
Picci
N
N
D000179:Acrylates / Q000737:chemistry*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D002152:Calorimetry, Differential Scanning; D003432:Cross-Linking Reagents; D016503:Drug Delivery Systems; D005079:Excipients; D005472:Fluorouracil / Q000008:administration & dosage*; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D008970:Molecular Weight; D010316:Particle Size; D011506:Proteins / Q000737:chemistry*
D000179:Acrylates; D000964:Antimetabolites, Antineoplastic; D003432:Cross-Linking Reagents; D005079:Excipients; D020100:Hydrogels; D007202:Indicators and Reagents; D011506:Proteins; D005472:Fluorouracil