title: An unusual presentation of diffuse granuloma annulare in an HIV-positive patient - immunohistochemical evidence of predominant CD8 lymphocytes.
abstract: Over the past decade there have been several reports in the literature of atypical forms of granuloma annulare (GA) occurring in HIV positive patients. We now report a case of diffuse granuloma annulare in an HIV positive patient with unusual clinical and immunohistological features. Our patient presented with a persistent extensive macular erythematous eruption on his face and upper trunk with bizarre sparing around the nipples and axillae. The histology showed an interstitial pattern of GA, with a predominance of CD8 positive cells, in contrast to the usual CD4 positive infiltrate typically seen in GA.
authors.affiliation: St John's Institute of Dermatology, St Thomas' Hospital, London, UK. drsm@doctorsnet.co.uk
authors.forename: S D
authors.initials: SD
authors.lastname: Morris
authors.forename: R
authors.initials: R
authors.lastname: Cerio
authors.forename: D G
authors.initials: DG
authors.lastname: Paige
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000473:pathology*; D016460:Granuloma Annulare / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006679:HIV Seropositivity / Q000150:complications* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged