[Induced interstitial pneumonitis: role of pegylated interferon alpha 2b].
Pulmonary complications of alpha interferon are rare. We report two cases of lung complications in liver transplantation patients for HCV related cirrhosis. After switching from interferon alpha to pegylated interferon alpha 2b, one patient developed a BOOP (Bronchiolitis Obliterans Organizing Pneumonia) and the other severe interstitial pneumonitis. We discuss the causes of these rare pulmonary alpha-interferon induced complications and the different way to suggest that the pegylated interferon alpha 2b could be related to the risk of pulmonary toxicity of this treatment.
Rocca
Pierre
P
Fédération des Spécialités Digestives, Hôpital Edouard Herriot, France.
Dumortier
Jérôme
J
Tanière
Philippe
P
Duperret
Serge
S
Vial
Thierry
T
Cottin
Vincent
V
Delafosse
Bertrand
B
Scoazec
Jean-Yves
JY
Boillot
Olivier
O
D000328:Adult; D006526:Hepatitis C / Q000473:pathology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects*; D008103:Liver Cirrhosis / Q000601:surgery; D016031:Liver Transplantation; D008168:Lung / Q000187:drug effects; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols; D011994:Recombinant Proteins
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C417083:peginterferon alfa-2b; C100416:peginterferon alfa-2a
Forme pegylée de l'interféron alpha 2b et pneumopathies interstitielles diffuses.