title: Utilization of supercritical carbon dioxide for complex formation of ibuprofen and methyl-beta-cyclodextrin.
abstract: The dissolution rate of a drug into the biological environment can be enhanced by forming complexes with cyclodextrins and their derivatives. In this study, ibuprofen-methyl-beta-cyclodextrin complexes were prepared successfully by passing ibuprofen-laden CO(2) through a methyl-beta-cyclodextrin packed bed. The maximum drug loading obtained in this work was 10.8 wt.%, which was comparable to that of a 1:1 complex (13.6 wt.% of ibuprofen). The complex exhibited instantaneous dissolution profiles in water solution. The enhanced dissolution rate was attributed to the amorphous character and improved wettability of the product.
authors.affiliation: School of Chemical Engineering and Industrial Chemistry, The University of New South Wales, Sydney 2052, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Charoenchaitrakool
authors.forename: F
authors.initials: F
authors.lastname: Dehghani
authors.forename: N R
authors.initials: NR
authors.lastname: Foster
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002245:Carbon Dioxide / Q000737:chemistry; D018360:Crystallography, X-Ray; D003505:Cyclodextrins; D004339:Drug Compounding; D005079:Excipients; D007052:Ibuprofen / Q000737:chemistry*; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D011312:Pressure; D012995:Solubility; D047392:beta-Cyclodextrins
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003505:Cyclodextrins; D005079:Excipients; D047392:beta-Cyclodextrins; C108732:methyl-beta-cyclodextrin; D002245:Carbon Dioxide; D007052:Ibuprofen