Neuroprotection and reduced proliferation of microglia in ribavirin-treated bornavirus-infected rats.
In a rat model of Borna disease, intracerebral ribavirin caused clinical improvement without changes in virus titer or nucleic acid. Levels of microglia and infiltrating CD4 and CD8 cells were decreased, despite increases in mRNAs encoding interleukin-1beta (IL-1beta), IL-10, and gamma interferon in the brain. Intracerebral ribavirin may reduce morbidity through effects on microglia cell proliferation.
Solbrig
Marylou V
MV
Emerging Diseases Laboratory, University of California-Irvine, Irvine, CA, USA.
Schlaberg
Robert
R
Briese
Thomas
T
Horscroft
Nigel
N
Lipkin
W Ian
WI
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D001890:Borna Disease / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D001891:Borna disease virus / Q000276:immunology; D001921:Brain / Q000378:metabolism / Q000821:virology; D002455:Cell Division / Q000187:drug effects; D016207:Cytokines / Q000235:genetics; D008297:Male; D017628:Microglia / Q000166:cytology / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis; D051381:Rats; D011917:Rats, Inbred Lew; D012254:Ribavirin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000276:immunology
D000998:Antiviral Agents; D016207:Cytokines; D018696:Neuroprotective Agents; D012333:RNA, Messenger; D012367:RNA, Viral; D012254:Ribavirin