title: Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: clinical manifestation and dosimetric description.
abstract: Twelve patients with hepatocellular carcinoma and chronic hepatitis developed radiation-induced liver disease (RILD) after three-dimensional conformal radiotherapy. Six patients died of RILD and six recovered. Mean prescribed dose was 50.6+/-4.3Gy, in a daily fraction of 1.8-2.0Gy. Commonly used dosimetric parameters, such as fraction volume of normal liver with radiation dose >30Gy, prediction score, and normal tissue complication probability, failed to differentiate the fatality and clinical types of this complication. Elevated transaminases are more frequently seen than ascites and elevated alkaline phosphamide are seen in patients with RILD.
authors.affiliation: Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, No. 125 Lih-Der Road, Pei-Tou, Taipei, Taiwan, ROC.
authors.forename: Jason Chia-Hsien
authors.initials: JC
authors.lastname: Cheng
authors.forename: Jian Kuen
authors.initials: JK
authors.lastname: Wu
authors.forename: Chao Ming
authors.initials: CM
authors.lastname: Huang
authors.forename: David Y
authors.initials: DY
authors.lastname: Huang
authors.forename: Skye H
authors.initials: SH
authors.lastname: Cheng
authors.forename: Yu Mong
authors.initials: YM
authors.lastname: Lin
authors.forename: James J
authors.initials: JJ
authors.lastname: Jian
authors.forename: Po Sheng
authors.initials: PS
authors.lastname: Yang
authors.forename: Vincent P
authors.initials: VP
authors.lastname: Chuang
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000532:radiotherapy*; D003937:Diagnosis, Differential; D005260:Female; D006521:Hepatitis, Chronic / Q000150:complications; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis* / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000175:diagnosis* / Q000209:etiology*; D011874:Radiometry; D020266:Radiotherapy, Conformal / Q000009:adverse effects*