title: Prognostic value of the clinical and laboratory evaluation in patients with nonmosaic Klinefelter syndrome who are receiving assisted reproductive therapy.
abstract: OBJECTIVE
  To characterize clinical and laboratory findings in nonmosaic 47,XXY patients that may help to predict spermatogenetic activity in their testicles.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Assisted reproductive technology program.
  
  
  METHODS
  Twenty patients with nonmosaic Klinefelter syndrome who underwent testicular sperm retrieval for IVF.
  
  
  METHODS
  The correlation between basal FSH, LH and testosterone levels, mean testicular volume, and results of the hCG test and presence or absence of sperm after testicular sperm extraction (TESE).
  
  
  RESULTS
  Sperm was found in nine patients (45%). The mean testicular volume was 7.8 +/- 2.5 mL in men with sperm after TESE and 5.6 +/- 1.2 mL in those without sperm after TESE; corresponding testosterone levels were 3.5 +/- 1.2 ng/mL and 1.7 +/- 0.8 ng/mL. Serum levels of FSH and LH did not significantly differ between groups. After the hCG test, the mean serum testosterone level was 16.0 +/- 6.3 ng/mL in men with sperm after TESE and 6.7 +/- 5.6 ng/mL in those without sperm.
  
  
  CONCLUSIONS
  Testicular volume, testosterone levels, and results of the hCG test are important predictive factors of spermatogenesis in patients with nonmosaic Klinefelter syndrome.
authors.affiliation: Male Infertility, Department of Urology and Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Igael
authors.initials: I
authors.lastname: Madgar
authors.forename: Jehoshua
authors.initials: J
authors.lastname: Dor
authors.forename: Ruth
authors.initials: R
authors.lastname: Weissenberg
authors.forename: Gil
authors.initials: G
authors.lastname: Raviv
authors.forename: Yehezkel
authors.initials: Y
authors.lastname: Menashe
authors.forename: Jacob
authors.initials: J
authors.lastname: Levron
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007713:Klinefelter Syndrome / Q000097:blood* / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009030:Mosaicism; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D013094:Spermatozoa / Q000473:pathology; D013737:Testis / Q000473:pathology; D013739:Testosterone / Q000097:blood; D020858:Tissue and Organ Harvesting
chemical_list: D006063:Chorionic Gonadotropin; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone