title: Fluoride release and caries inhibition associated with a resin-modified glass-ionomer cement at varying fluoride loading doses.
abstract: OBJECTIVE
  To measure, over time, the release of fluoride from a resin-modified glass-ionomer cement, loaded with different levels of fluoride, then to evaluate the adjacent dentin demineralization inhibition relative to these fluoride levels.
  
  
  METHODS
  (Phase I) 25 standardized discs were fabricated from a non-fluoridated resin-based composite (control), resin-modified glass-ionomer cement and resin-modified glass-ionomer cement loaded with sodium fluoride at 1%, 2% and 3% by weight fluoride. Fluoride release was evaluated over 30 days. (Phase II) 50 restorations, from the materials listed in Phase I, were placed as Class V restorations in teeth, the teeth were acid-challenged, then dentin margins adjacent to restoration margins were evaluated for demineralization.
  
  
  RESULTS
  As sodium fluoride additions increased, fluoride release increased. Evaluation of demineralization indicated the resin-modified glass-ionomer cement inhibited adjacent demineralization in a direct relationship with sodium fluoride concentration where 3% fluoride exhibited significantly less adjacent demineralization than all other groups; 2% and 1% fluoride exhibited significantly less adjacent demineralization than the non-loaded resin-modified glass-ionomer cement and non-fluoridated resin-based composite control (P< 0.05).
authors.affiliation: Department of Pediatric Dentistry, Dental School, University of Texas Health Science Center at San Antonio, 78229, USA. donly@uthscsa.edu
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Donly
authors.forename: Adriana
authors.initials: A
authors.lastname: Segura
mesh_terms: D000134:Acid Etching, Dental; D000704:Analysis of Variance; D017438:Bisphenol A-Glycidyl Methacrylate / Q000737:chemistry / Q000627:therapeutic use; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000627:therapeutic use; D003188:Composite Resins / Q000737:chemistry / Q000627:therapeutic use; D003731:Dental Caries / Q000517:prevention & control*; D003737:Dental Cavity Preparation / Q000145:classification; D003743:Dental Enamel / Q000187:drug effects / Q000648:ultrastructure; D003793:Dental Restoration, Permanent / Q000145:classification; D003804:Dentin / Q000187:drug effects / Q000648:ultrastructure; D004058:Diffusion; D004305:Dose-Response Relationship, Drug; D005899:Glass Ionomer Cements / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D019279:Resin Cements / Q000737:chemistry* / Q000627:therapeutic use; D012464:Saliva, Artificial / Q000737:chemistry; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000737:chemistry* / Q000627:therapeutic use; D013223:Statistics as Topic; D013997:Time Factors; D017001:Tooth Demineralization / Q000517:prevention & control
chemical_list: D002327:Cariostatic Agents; D003188:Composite Resins; D005899:Glass Ionomer Cements; D019279:Resin Cements; D012464:Saliva, Artificial; C084550:Vitremer; C065771:P50 composite resin; D017438:Bisphenol A-Glycidyl Methacrylate; D012969:Sodium Fluoride