title: Discriminant value of blood and urinary corticoids for the diagnosis of scrapie in live sheep.
abstract: The mean (sd) concentration of plasma 20beta-dihydrocortisol in 126 scrapie-affected sheep was 5-5 (7.0) ng/ml compared with 1.1 (0.7) ng/ml in 52 healthy sheep. The mean (sd) concentration of creatinine in the urine of 93 scrapie-affected sheep was 2.43 (1.56) microg/ml compared with 0.94 (0.86) pg/ml in 49 healthy sheep and 1.10 (0-95) pg/ml in 25 sheep with other diseases. These discriminant analyses carried out on healthy and scrapie-affected sheep showed that plasma 20beta-dihydrocortisol and urinary creatinine were the best predictors of the disease, and classified correctly 98 per cent of healthy sheep and 82 per cent of scrapie-affected sheep.
authors.affiliation: Unité Mixte de Recherche, INRA-ENVT 181, Ecole Nationale Vétérinaire de Toulouse, France.
authors.forename: N
authors.initials: N
authors.lastname: Picard-Hagen
authors.forename: V
authors.initials: V
authors.lastname: Gayrard
authors.forename: V
authors.initials: V
authors.lastname: Laroute
authors.forename: C
authors.initials: C
authors.lastname: Grandjean
authors.forename: O
authors.initials: O
authors.lastname: Andreoletti
authors.forename: J M
authors.initials: JM
authors.lastname: Elsen
authors.forename: F
authors.initials: F
authors.lastname: Schelcher
authors.forename: P L
authors.initials: PL
authors.lastname: Toutain
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine*; D005260:Female; D006403:Hematologic Tests / Q000592:standards / Q000662:veterinary; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000097:blood*; D008297:Male; D011237:Predictive Value of Tests; D011247:Pregnancy; D012608:Scrapie / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D012756:Sheep; D016482:Urinalysis / Q000592:standards / Q000662:veterinary
chemical_list: D015415:Biomarkers; C016499:20-hydroxycortisol; D003404:Creatinine; D006854:Hydrocortisone