title: Kallmann syndrome: adhesion, afferents, and anosmia.
abstract: Three new studies into the function of human anosmin-1 and related proteins in C. elegans and rodents show that these influence axon branching and axon targeting. The rodent anosmin appears to work at two stages of development, initially promoting axon outgrowth from the olfactory bulb and then stimulating branching from axons into the olfactory cortex. CeKal-1 further influences morphogenesis, and, as the human and nematode anosmins are functionally conserved, these studies provide insights into the pathogenesis of Kallmann syndrome (KS).
authors.affiliation: Neuroendocrine Unit, Department of Medicine, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, United Kingdom.
authors.forename: Gavin
authors.initials: G
authors.lastname: MacColl
authors.forename: Pierre
authors.initials: P
authors.lastname: Bouloux
authors.forename: Richard
authors.initials: R
authors.lastname: Quinton
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000172:deficiency / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics*; D002465:Cell Movement / Q000235:genetics*; D016326:Extracellular Matrix Proteins; D006801:Humans; D017436:Kallmann Syndrome / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics; D000857:Olfaction Disorders / Q000235:genetics*; D009833:Olfactory Pathways / Q000002:abnormalities* / Q000378:metabolism / Q000503:physiopathology
chemical_list: C076266:ANOS1 protein, human; D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins