title: [Determination of maximum permissible concentrations of industrial toxicants using the integral biochemical index].
abstract: Effects of patented mixtures of substances, used as drilling fluids in petroleum industry, on the activity of enzymes (cathepsin D, EC 3.4.23.5; catalase, EC 1.11.1.6; and DNase, EC 3.1.4.6) and the content of analytes (malondialdehyde, fatty acids, free and collagen-associated hydroxyproline, bile acids, and total protein) in liver, gills, muscles, gonads, and bile have been studied under aquarium conditions in mature river flounder and one-year-old salmon for the purpose of determining maximum permissible concentrations. Measuring 25-30 independent biochemical parameters per organ is sufficient for establishing a direct relationship between the concentration of an industrial toxicant and the integral biochemical index, a new characteristic defined as the ratio of the number of biochemical parameters significantly deviating from control values to the total number of the parameters measured.
authors.affiliation: Institute of Biology, Karelian Research Center, Russian Academy of Sciences, Petrozavodsk, 185610 Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Sidorov
authors.forename: N N
authors.initials: NN
authors.lastname: Nemova
authors.forename: R U
authors.initials: RU
authors.lastname: Vysotskaia
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Feklov
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D002374:Catalase / Q000378:metabolism; D002403:Cathepsins / Q000378:metabolism; D003851:Deoxyribonucleases / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis; D005432:Flounder / Q000378:metabolism*; D006909:Hydroxyproline / Q000032:analysis; D008315:Malondialdehyde / Q000032:analysis; D008452:Maximum Allowable Concentration; D010578:Petroleum; D011506:Proteins / Q000032:analysis; D012474:Salmon / Q000378:metabolism*; D014018:Tissue Distribution; D014116:Toxicology / Q000379:methods; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D001647:Bile Acids and Salts; D005227:Fatty Acids; D010578:Petroleum; D011506:Proteins; D014874:Water Pollutants, Chemical; D008315:Malondialdehyde; D002374:Catalase; D003851:Deoxyribonucleases; D002403:Cathepsins; D006909:Hydroxyproline
vernacular_title: Ispol'zovanie integral'nogo biokhimicheskogo indeksa pri opredelenii predel'no dopustimykh kontsentratsiĭ promyshlennykh toksikantov.