title: Concordance as well as discordance for congenital malformations in valproate-exposed half-siblings with parental consanguinity may indicate a specific gene-teratogen interaction.
abstract: The possibility of gene-teratogen interaction is suggested in a family formerly reported by Gardner et al. [(2001) Clin Dysmorphol 10:203-208] in which both concordance and discordance exist for congenital malformations in equally valproate-exposed siblings.
authors.forename: K
authors.initials: K
authors.lastname: ten Berg
authors.forename: D
authors.initials: D
authors.lastname: Lindhout
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D003241:Consanguinity; D006801:Humans; D013723:Teratogens / Q000633:toxicity*; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D013723:Teratogens; D014635:Valproic Acid