CD83 on dendritic cells: more than just a marker for maturation.
CD83 has been known for a long time to be one of the best markers for mature dendritic cells (DCs). Studies with herpes simplex virus type 1 (HSV-1)-infected DCs, whereby the viral infection leads to the degradation of CD83, as well as investigations inhibiting CD83 mRNA transport, have provided evidence that CD83 might also be important for DC biology. Recently, we have shown that the soluble extracellular CD83 domain inhibits DC-mediated T-cell proliferation, representing the first report describing a functional role for CD83.
Lechmann
Matthias
M
Dept of Dermatology, University of Erlangen-Nürnberg, Hartmannstrasse 14, D-91052, Erlangen, Germany.
Berchtold
Susanne
S
Hauber
Joachim
J
Steinkasserer
Alexander
A
D000818:Animals; D015703:Antigens, CD; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry / Q000502:physiology*; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D010448:Peptide Initiation Factors / Q000378:metabolism; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins; D011993:Recombinant Fusion Proteins / Q000502:physiology; D018139:Simplexvirus / Q000502:physiology; D012995:Solubility; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D000097574:Eukaryotic Translation Initiation Factor 5A; D000097802:CD83 Antigen
D015703:Antigens, CD; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D010448:Peptide Initiation Factors; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D011993:Recombinant Fusion Proteins; D000097574:Eukaryotic Translation Initiation Factor 5A; D000097802:CD83 Antigen