[Inducible nitric oxide synthase in rat lungs in experimental bronchial asthma and its status in administering drugs with adrenergic action].
The state of inducible NO-synthase (iNOs) in the rat lung with experimental model of bronchial asthma (BA) was studied after administrating short-acting beta 2-agonist fenoterol, long-acting beta 2-agonist salmeterol, and adrenoblocker propranolol. Administrated beta 2-agonists were observed to result in reducing iNOs activity in the rats with BA, while propranolol intensified iNOs expression.
Eliseeva
E V
EV
Vladivostok State Medical University. aeliseef@rbcmail.ru
D058666:Adrenergic beta-2 Receptor Agonists; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000420:Albuterol / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D000818:Animals; D001249:Asthma / Q000201:enzymology*; D005280:Fenoterol / Q000008:administration & dosage*; D008168:Lung / Q000201:enzymology*; D008297:Male; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II; D011433:Propranolol / Q000008:administration & dosage*; D051381:Rats; D000068299:Salmeterol Xinafoate
D058666:Adrenergic beta-2 Receptor Agonists; D000319:Adrenergic beta-Antagonists; D005280:Fenoterol; D000068299:Salmeterol Xinafoate; D011433:Propranolol; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D000420:Albuterol
Indutsibel'naia nitrooksidsintaza v legkikh krys s éksperimental'noĭ bronkhial'noĭ astmoĭ i ee sostoianie pri vvedenii preparatov adrenergicheskogo deĭstviia.