title: Sotos syndrome (cerebral gigantism): analysis of 8 cases.
abstract: Sotos syndrome or cerebral gigantism is characterized by macrocephaly, overgrowth, mental retardation and central nervous system abnormalities. Congenital heart defects may be present. We report 8 patients with this syndrome and relate their clinical features, neuroimaging and echocardiographic findings.
authors.affiliation: Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Riberão Preto, SP, Brazil.
authors.forename: Débora Gusmão
authors.initials: DG
authors.lastname: Melo
authors.forename: Angelina Xavier
authors.initials: AX
authors.lastname: Acosta
authors.forename: Maria Aparecida de Almeida
authors.initials: MA
authors.lastname: Salles
authors.forename: João Monteiro de
authors.initials: JM
authors.lastname: Pina-Neto
authors.forename: José Daniel Vieira de
authors.initials: JD
authors.lastname: Castro
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Santos
mesh_terms: D000015:Abnormalities, Multiple / Q000209:etiology / Q000503:physiopathology; D000293:Adolescent; D001921:Brain / Q000002:abnormalities*; D002648:Child; D002675:Child, Preschool; D019465:Craniofacial Abnormalities / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005877:Gigantism / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008607:Intellectual Disability / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D013577:Syndrome