title: Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion.
abstract: This article represents the proceedings of a symposium at the 2001 Research Society on Alcoholism meeting in Montreal, Canada. The chairs were Alan Cahill and Carol C. Cunningham. The presentations were (1) Mitochondrial regulation of ethanol-induced hepatocyte apoptosis: possible involvement of proapoptotic Bcl-2 family protein Bax, by Masayuki Adachi and Hiromasa Ishii; (2) Effects of ethanol on mitochondrial reactive oxygen species production and oxidative protein modification, by Shannon M. Bailey; (3) Acute ethanol binges elicit widespread oxidative mitochondrial DNA damage and depletion: protective effects of antioxidants and inhibitors of ethanol metabolism, by Bernard Fromenty; and (4) Effects of chronic ethanol consumption upon hepatic mtDNA oxidative modification and depletion, by Alan Cahill and Adrian Davies.
authors.affiliation: Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. alan.cahill@mail.tju.edu
authors.forename: Alan
authors.initials: A
authors.lastname: Cahill
authors.forename: Carol C
authors.initials: CC
authors.lastname: Cunningham
authors.forename: Masayuki
authors.initials: M
authors.lastname: Adachi
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ishii
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Bailey
authors.forename: Bernard
authors.initials: B
authors.lastname: Fromenty
authors.forename: Adrian
authors.initials: A
authors.lastname: Davies
mesh_terms: D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000502:physiology; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology
chemical_list: D000431:Ethanol