title: Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation.
abstract: Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC(50)=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.
authors.affiliation: Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, 98 Kunja-dong, Kwangjin-gu, 143-747 Seoul, Republic of Korea.
authors.forename: Joong Sup
authors.initials: JS
authors.lastname: Shim
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Kim
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Jung
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Dongyeol
authors.initials: D
authors.lastname: Lim
authors.forename: Seok-Ki
authors.initials: SK
authors.lastname: Lee
authors.forename: Kyu-Won
authors.initials: KW
authors.lastname: Kim
authors.forename: Jong Woong
authors.initials: JW
authors.lastname: Ahn
authors.forename: Jong-Shin
authors.initials: JS
authors.lastname: Yoo
authors.forename: Jung-Rae
authors.initials: JR
authors.lastname: Rho
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.forename: Ho Jeong
authors.initials: HJ
authors.lastname: Kwon
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002642:Chick Embryo; D003474:Curcumin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018919:Neovascularization, Physiologic / Q000187:drug effects
chemical_list: D020533:Angiogenesis Inhibitors; D006834:Hydrazines; C475807:hydrazinocurcumin; D003474:Curcumin