A cytotoxic diterpenoid and antifungal phenolic compounds from Frullania muscicola Steph.
A novel ent-labdane type diterpenoid, muscicolone (1), as well as two bibenzyls (2, 3) and four flavonoids (4-7) were isolated from the liverwort Frullania muscicola Steph. Their structures were established by analysis of the spectral data of IR, UV, ID-, 2D-NMR, and ORD. The stereostructure of 1 was confirmed by X-ray crystallographic analysis. Bioassay experiments showed that compound 3 and 4 have potent inhibitory effects against some fungi while 1 showed cytotoxic effects to some human tumor cells.
Lou
Hong-Xiang
HX
Department of Natural Product Chemistry, School of Pharmacy, Shandong University, Shandong Jinan, China. hxlou@jn-public.sd.cninfo.net
Li
Guang-Yao
GY
Wang
Feng-Qiang
FQ
D000935:Antifungal Agents / Q000494:pharmacology; D001681:Biological Assay; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D037961:Frullania / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D004224:Diterpenes; D005419:Flavonoids; C468416:muscicolone