A new lanostane-type triterpene from the fruiting bodies of Ganoderma lucidum.
A new lanostane-type triterpene, named ganoderic acid LM2 (5), was isolated from the fruiting bodies of Ganoderma lucidum. Its structure was characterized as (23S) 7beta, -dihydroxy-3, 11, 15-trioxo-5alpha-lanosta-8, 24-dien-26-oic acid by 1D- and 2D-NMR spectra. In addition, a known triterpene, ganoderic acid epsilon (4), was obtained. Both of them exhibited potent enhancement of ConA-induced mice splenocytes proliferation in vitro.
Luo
Jun
J
Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing, China.
Zhao
Yu-Ying
YY
Li
Zhi-Bin
ZB
D000818:Animals; D001681:Biological Assay; D002455:Cell Division / Q000187:drug effects; D005638:Fruit / Q000737:chemistry; D051379:Mice; D020940:Reishi / Q000737:chemistry*; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D014315:Triterpenes; C468428:ganoderic acid LM2