title: Gestational trophoblastic disease.
abstract: Patients diagnosed with molar pregnancy are treated by either suction curettage or hysterectomy, depending on their desire to preserve fertility. We use single-agent chemotherapy, preferably methotrexate, to treat low- or moderate-risk persistent trophoblastic tumors. High-risk patients who have metastatic disease are treated primarily with combination chemotherapy and, as indicated, adjuvant radiotherapy or surgery. We perform a hysterectomy in all cases of placental-site trophoblastic tumors; combination chemotherapy is used if there is evidence of metastatic disease.
authors.affiliation: Division of Gynecologic Oncology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: J O
authors.initials: JO
authors.lastname: Schorge
authors.forename: D P
authors.initials: DP
authors.lastname: Goldstein
authors.forename: M R
authors.initials: MR
authors.lastname: Bernstein
authors.forename: R S
authors.initials: RS
authors.lastname: Berkowitz
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D011247:Pregnancy; D011379:Prognosis; D011882:Radiotherapy, High-Energy; D012074:Remission Induction; D014328:Trophoblastic Neoplasms / Q000628:therapy*; D014594:Uterine Neoplasms / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents