Antigenic heterogeneity amongst the field isolates of Newcastle Disease Virus (NDV) in relation to the vaccine strain. Part II: studies on viruses isolated from domestic birds in Israel.
Forty three Newcastle disease virus (NDV) strains isolated before and during 1997 in Israel from domestic birds were studied by means of the three panels of monoclonal antibodies prepared against all the viral envelope proteins in order to reveal the possible antigenic differences between them and the VH strain used in Israel for poultry vaccination. Three isolates were found to have significant antigenic differences in the hemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins as compared to the vaccine strain. As to the matrix protein, almost all the viruses isolated during the year 1997 were found to have considerable differences from the vaccine strain in two of four antigenic sites.
Panshin
A
A
Division of Avian Diseases, Kimron Veterinary Institute, Beit Dagan, Israel. panshin@netvision.net.il
Shihmanter
E
E
Weisman
Y
Y
Orvell
C
C
Lipkind
M
M
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000276:immunology; D000940:Antigenic Variation; D015478:Antigens, Heterophile / Q000235:genetics / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D002645:Chickens; D004372:Ducks; D000939:Epitopes / Q000032:analysis / Q000145:classification / Q000276:immunology; D015707:HN Protein / Q000276:immunology; D007557:Israel; D009522:Newcastle disease virus / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification*; D011201:Poultry Diseases / Q000235:genetics / Q000517:prevention & control / Q000821:virology*; D040081:Protein Array Analysis; D014422:Turkeys; D014765:Viral Vaccines / Q000032:analysis / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015478:Antigens, Heterophile; D000956:Antigens, Viral; D000939:Epitopes; D015707:HN Protein; D014765:Viral Vaccines