Successful sequential liver and stem cell transplantation for hepatic failure due to primary AL amyloidosis.
We report on a patient with primary AL amyloidosis who presented with progressive liver failure secondary to hepatic infiltration in the absence of significant extrahepatic involvement. Orthotopic liver transplantation was performed successfully. After an uneventful postoperative course, the patient developed evidence of significant recurrent amyloidosis requiring treatment. He then underwent stem cell transplantation 10 and 14 months after liver transplantation. After 28 months of follow-up posttransplantation, the patient continues to do well, with no clinical evidence of recurrent disease. This is the first reported patient with primary amyloidosis to undergo sequential liver and stem cell transplantation leading to resolution of the disease and only the second to undergo successful liver transplantation for this disorder.
Kumar
K Shiva
KS
Center for Liver Disease and Transplantation, New York-Presbyterian Hospital, New York 10036, USA.
Lefkowitch
Jay
J
Russo
Mark W
MW
Hesdorffer
Charles
C
Kinkhabwala
Milan
M
Kapur
Sandip
S
Emond
Jean C
JC
Brown
Robert S
RS
D000368:Aged; D000686:Amyloidosis / Q000145:classification / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008099:Liver / Q000473:pathology; D017093:Liver Failure / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D016896:Treatment Outcome