title: Effect of topical ophthalmic latanoprost on intraocular pressure in normal horses.
abstract: The ocular effects of latanoprost ophthalmic solution were evaluated in two studies, with eight horses in each study. One eye of each horse was treated with latanoprost ophthalmic solution once daily for 5 days, and the opposite eye received a control solution of sterile eyewash. Intraocular pressure and pupillary diameter were measured daily for 5 days after treatment. Latanoprost had no significant effect on intraocular pressure or pupillary diameter in normal horse eyes compared with control eyes in these studies. Placement of an eyelid nerve block resulted in significantly lower intraocular pressure.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA.
authors.forename: Harriet J
authors.initials: HJ
authors.lastname: Davidson
authors.forename: Chantale L
authors.initials: CL
authors.lastname: Pinard
authors.forename: Susan M
authors.initials: SM
authors.lastname: Keil
authors.forename: Alan H
authors.initials: AH
authors.lastname: Brightman
authors.forename: Jan M
authors.initials: JM
authors.lastname: Sargeant
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005901:Glaucoma / Q000517:prevention & control / Q000662:veterinary; D006734:Horse Diseases / Q000517:prevention & control; D006736:Horses / Q000502:physiology*; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011680:Pupil / Q000187:drug effects; D012016:Reference Values
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost