title: Comparison of corticosteroids for treatment of respiratory syncytial virus bronchiolitis and pneumonia in cotton rats.
abstract: Triamcinolone acetonide, methylprednisolone, and dexamethasone were each evaluated in combination with palivizumab (Synagis) for the therapy of established respiratory syncytial virus infection in the cotton rat. Triamcinolone and methylprednisolone proved to be more effective than dexamethasone in reducing lung pathology. No recurrence of viral replication or pulmonary pathology followed the cessation of therapy.
authors.affiliation: Department of Pediatric, F. Edward Hébert School of Medicine of the Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
authors.forename: Martin G
authors.initials: MG
authors.lastname: Ottolini
authors.forename: Spencer J
authors.initials: SJ
authors.lastname: Curtis
authors.forename: David D
authors.initials: DD
authors.lastname: Porter
authors.forename: Amy
authors.initials: A
authors.lastname: Mathews
authors.forename: Joann Y
authors.initials: JY
authors.lastname: Richardson
authors.forename: Val G
authors.initials: VG
authors.lastname: Hemming
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Prince
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D001988:Bronchiolitis / Q000188:drug therapy*; D000069455:Palivizumab; D011024:Pneumonia, Viral / Q000188:drug therapy*; D012008:Recurrence; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy*; D016205:Sigmodontinae; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000069455:Palivizumab