title: A comparative study on the effect of praziquantel and triclabendazole on Vampirolepis nana in vitro.
abstract: V. nana was frequently associated with Schistosoma mansoni and Fasciola spp. This study was conducted to investigate and compare the effects of praziquantel and triclabendazole on V. nana worms, after in vitro exposure to 1 and 2 microg/ml of each of praziquantel or triclabendazole. All the worms were put under observation for 30 minutes. The worm mortality rates were recorded and the topographic tegumental changes were studied by scanning electron microscopy. The results demonstrated that praziquantel showed comparatively superior effect on adult V. nana worms than triclabendazole. The latter still revealed an anthelmintic effect.
authors.affiliation: Department of Parasitology, Medical Research Institute, Alexandria University, Egypt.
authors.forename: Mona H
authors.initials: MH
authors.lastname: el-Sayad
authors.forename: Wael M
authors.initials: WM
authors.lastname: Lotfy
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002589:Cestoda / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D002590:Cestode Infections / Q000188:drug therapy / Q000469:parasitology; D051379:Mice; D008855:Microscopy, Electron, Scanning; D011223:Praziquantel / Q000494:pharmacology*; D016896:Treatment Outcome; D000077682:Triclabendazole
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole; D011223:Praziquantel