Diagnosis and treatment of Paget's disease of bone.
Paget's disease of bone (also known as osteitis deformans) is a nonmalignant disease involving accelerated bone resorption followed by deposition of dense, chaotic, and ineffectively mineralized bone matrix. The origin of the disease is unknown, and it is frequently asymptomatic; however, the patient may present with symptoms depending on the bones involved. The most common symptom is pain in the affected bone; neurologic, hearing, vision, cardiac, and oncologic complications are possible. Diagnosis is primarily made by radiographs. Bisphosphonates are the most common treatment.
Schneider
Doron
D
Department of Internal Medicine and the Muller Center for Senior Health, Abington Memorial Hospital, Pennsylvania 19001-3788, USA.
Hofmann
Mary T
MT
Peterson
Jeannette A
JA
D002116:Calcitonin / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D010001:Osteitis Deformans / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
D004164:Diphosphonates; D002116:Calcitonin