title: Concurrent occurrence of chylothorax, chylous ascites, and protein-losing enteropathy in systemic lupus erythematosus.
abstract: We describe 2 patients with systemic lupus erythematosus (SLE) who presented with chylothorax, chylous ascites, and protein-losing enteropathy. Analysis of pleural or peritoneal fluid revealed a high level of triglyceride and elevated 24 h stool alpha1-antitrypsin clearance in keeping with protein-losing enteropathy. One patient failed to respond to high dose corticosteroid therapy but recovered after 3 cycles of monthly cyclophosphamide treatment. The other patient initially responded to high dose corticosteroid therapy, but succumbed to infectious complications. This is the first report of occurrence of chylothorax and chylous ascites associated with SLE.
authors.affiliation: Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Chang-Keun
authors.initials: CK
authors.lastname: Lee
authors.forename: Ji Min
authors.initials: JM
authors.lastname: Han
authors.forename: Kung No
authors.initials: KN
authors.lastname: Lee
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Lee
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Shin
authors.forename: You-Sook
authors.initials: YS
authors.lastname: Cho
authors.forename: Younsuck
authors.initials: Y
authors.lastname: Koh
authors.forename: Bin
authors.initials: B
authors.lastname: Yoo
authors.forename: Hee-Boom
authors.initials: HB
authors.lastname: Moon
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000368:Aged; D002916:Chylothorax / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002915:Chylous Ascites / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D018450:Disease Progression; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007723:Korea; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011504:Protein-Losing Enteropathies / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D011877:Radionuclide Imaging
chemical_list: D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide