Acute pancreatitis and acute renal failure complicating doxylamine succinate intoxication.
Doxylamine succinate is an antihistaminic drugwith additional hypnotic, anticholinergic and local anesthetic effects first described in 1948. In Korea and many other countries, it is a common-over-the counter medication frequently involved in overdoses. Clinical symtomatology of doxylamine succinate overdose includes somnolence, coma, seizures, mydriasis, tachycardia, psychosis, and rhabdomyolysis. A serious complication may be rhabdomyolysis with subsequent impairment of renal function and acute renal failure. We report a case of acute renal failure and acute pancreatitis complicating a doxylamine succinate intoxication.
Lee
Yang Deok
YD
Department of Internal Medicine, Chonbuk National University Medical School, Chonju, Republic of Korea.
Lee
Soo Teik
ST
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D000328:Adult; D003937:Diagnosis, Differential; D004319:Doxylamine / Q000506:poisoning*; D062787:Drug Overdose / Q000150:complications / Q000175:diagnosis; D004638:Emergency Treatment; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning*; D008297:Male; D010195:Pancreatitis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy
D006993:Hypnotics and Sedatives; D004319:Doxylamine