Challenges in developing a molecular characterization of cancer.
DNA microarrays are widely used to measure gene expression across thousands of genes in parallel. Recently, considerable efforts have been made to utilize this technology to improve our understanding of cancer and to identify novel diagnostic markers and therapeutic targets. Here, we detail some of the challenges in developing a molecular characterization of cancer and in translating these new discoveries towards clinical utility.
Pollack
Jonathan R
JR
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Van de Rijn
Matt
M
Botstein
David
D
D020869:Gene Expression Profiling; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis