A library construction of 2,5-disubstituted pyrrole compounds by using solid/solution-phase syntheses.
Using solid- and solution-phase synthesis, a library of 2,5-disubstituted pyrrole compounds was constructed. This is the first report that Stetter reaction was applied to the solid-phase synthesis for C-C bond formation. Some of 2,5-disubstituted pyrrole compounds showed the inhibitory activity of LPS-induced mouse B-lymphocyte proliferation.
Kobayashi
Naoki
N
Discovery Technology Research Laboratories, Eisai Co., Ltd., 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki 300-2635, Japan. n2-kobayashi@hhc.eisai.co.jp
Kaku
Yumiko
Y
Higurashi
Kunizo
K
Yamauchi
Toshihiko
T
Ishibashi
Akira
A
Okamoto
Yasushi
Y
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D020650:Combinatorial Chemistry Techniques; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D018168:Receptors, Retinoic Acid / Q000737:chemistry / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D014212:Tretinoin / Q000031:analogs & derivatives / Q000494:pharmacology
D008070:Lipopolysaccharides; D011758:Pyrroles; D018168:Receptors, Retinoic Acid; D014212:Tretinoin