title: Glutaric aciduria type I diagnosed after poliovirus immunization: magnetic resonance findings.
abstract: Glutaric aciduria type I is an uncommon inborn error of metabolism. It is a serious disease, often with a fatal outcome. Magnetic resonance imaging findings and the clinical course of monozygotic twin females with glutaric aciduria type I who were admitted with acute encephalopathic crisis symptoms 3 days after immunization for poliovirus are presented in this report. Magnetic resonance imaging findings revealed hyperintensity in the putamen, head of the left caudate nucleus, and globus pallidus, periventricular white matter (on T(2)-weighted images), arachnoid cysts in bilateral temporal regions, and enlargement of the sylvian fissures. Glutaric aciduria type I should be included in the differential diagnosis of patients with acute encephalopathic crisis occurring shortly after poliovirus immunization. Typical magnetic resonance findings guide urinary organic acid analysis in these patients.
authors.affiliation: Department of Radiology, Inönü Universitesi Turgut Ozal Tip Merkezi, Malatya, Turkey.
authors.forename: Alpay
authors.initials: A
authors.lastname: Alkan
authors.forename: Tamer
authors.initials: T
authors.lastname: Baysal
authors.forename: Cengiz
authors.initials: C
authors.lastname: Yakinci
authors.forename: Ahmet
authors.initials: A
authors.lastname: Sigirci
authors.forename: Ramazan
authors.initials: R
authors.lastname: Kutlu
mesh_terms: D003937:Diagnosis, Differential; D004660:Encephalitis / Q000139:chemically induced; D005260:Female; D005977:Glutarates / Q000652:urine*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data; D008661:Metabolism, Inborn Errors / Q000175:diagnosis* / Q000235:genetics / Q000652:urine; D023321:Poliovirus Vaccines / Q000009:adverse effects*; D014430:Twins, Monozygotic
chemical_list: D005977:Glutarates; D023321:Poliovirus Vaccines; C035736:glutaric acid