title: The slow isoform of Xenopus troponin I is expressed in developing skeletal muscle but not in the heart.
abstract: In birds and mammals three isoforms of troponin I (TnI) exist; a slow (TnIs), a fast (TnIf) and a cardiac (TnIc). Although each of these isoforms is expressed in the adult forms of these organisms in a muscle fiber-type-specific manner, the gene encoding TnIs is also expressed within the developing heart of these vertebrates. Herein, our results demonstrate that the developing heart of Xenopus laevis, unlike its counterpart in birds and mammals, does not express the gene encoding the TnIs isoform and that the expression of this gene, as well as the one encoding the Xenopus TnIf isoform, is restricted to skeletal muscle.
authors.affiliation: Molecular Genetics Unit, Department of Zoology, University of Western Ontario, London, Canada.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Warkman
authors.forename: Burr G
authors.initials: BG
authors.lastname: Atkinson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D015870:Gene Expression; D006321:Heart / Q000196:embryology; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D018482:Muscle, Skeletal / Q000196:embryology / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010802:Phylogeny; D020033:Protein Isoforms; D017386:Sequence Homology, Amino Acid; D019210:Troponin I / Q000145:classification / Q000235:genetics*; D014982:Xenopus laevis / Q000196:embryology / Q000235:genetics* / Q000378:metabolism
chemical_list: D018076:DNA, Complementary; D020033:Protein Isoforms; D019210:Troponin I