title: Low-dose mitomycin C, etoposide, and cisplatin for invasive vulvar Paget's disease.
abstract: We report the effect of low-dose mitomycin C, etoposide, and cisplatin (low-dose MEP) therapy for three patients with invasive vulvar Paget's disease (invasive VPD) who declined radical vulvectomy and skin grafting. One patient achieved a complete response, while the other two showed partial responses (PR) without grade 3 or 4 adverse effects. The two patients with PR were undergone partial vulvectomy and inguinal lymph node dissection. All patients have no sign of recurrence for 10 months after chemotherapy. Our present results suggest that low-dose MEP is an effective and safe chemotherapy for invasive VPD and low-dose MEP may significantly improve postoperative quality of life in patients with invasive VPD by avoiding extensive vulvar resection and skin grafting.
authors.affiliation: Department of Obstetrics and Gynecology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osakasayama, Osaka 589-8511, Japan. watanabe@med.kindai.ac.jp
authors.forename: Yoh
authors.initials: Y
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Hoshiai
authors.forename: H
authors.initials: H
authors.lastname: Ueda
authors.forename: H
authors.initials: H
authors.lastname: Nakai
authors.forename: K
authors.initials: K
authors.lastname: Obata
authors.forename: K
authors.initials: K
authors.lastname: Noda
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D016685:Mitomycin / Q000008:administration & dosage; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D010145:Paget Disease, Extramammary / Q000188:drug therapy* / Q000473:pathology; D011788:Quality of Life; D014846:Vulvar Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D016685:Mitomycin; D005047:Etoposide; D002945:Cisplatin