Neosordarin and hydroxysordarin, two new antifungal agents from Sordaria araneosa.
Two novel antifungal agents belonging to the sordarin family have been isolated from fermentations of Sordaria araneosa by bioassay-guided purification and their structures elucidated by NMR techniques. Neosordarin (1) is closely related to the recently discovered hypoxysordarin (2), with only small differences on the aliphatic side chain acylating the hydroxyl in the 3'-position of the sordarose moiety. Hydroxysordarin (3) closely resembles sordarin (4), the only slight difference being the replacement of sordarose with altrose as the sugar unit.
Davoli
Paolo
P
Lehrbereich Biotechnologie der Universität, Kaiserslautern, Germany.
Engel
Günther
G
Werle
Andreas
A
Sterner
Olov
O
Anke
Timm
T
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D003470:Culture Media; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D007192:Indenes; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests / Q000379:methods
D000935:Antifungal Agents; D003470:Culture Media; D007192:Indenes; C458899:hydroxysordarin; C458900:neosordarin