title: Circadian period lengths of lipid synthesis mutants (cel, chol-1) of Neurospora show defective temperature, but intact pH-compensation.
abstract: The influence of extracellular pH on the circadian sporulation rhythm of Neurospora crassa has been investigated for the mutants chol-1 and cel. Both mutants have a defect in the lipid synthesis pathway and require either choline or palmitate, respectively, as supplements for normal growth. The chol-1 and cel mutants also show an impaired temperature-compensation when growing on minimal medium. We investigated the possible correlation between loss of temperature- and pH-compensation in cel and chol-1 similar to the correlation found earlier for the frq7 mutant. Our results show that the cel and the chol-1 mutants, although defective in temperature-compensation have an intact pH-compensation of their circadian rhythms. At present, the products of the frq-locus are the only components of the clock that affect the sporulation rhythm of Neurospora both through pH- and temperature-compensation.
authors.affiliation: School of Science and Technology, Stavanger University College, Norway. peter.ruoff@tn.his.no
authors.forename: Peter
authors.initials: P
authors.lastname: Ruoff
authors.forename: Ieda
authors.initials: I
authors.lastname: Slewa
mesh_terms: D002794:Choline / Q000494:pharmacology; D002940:Circadian Rhythm / Q000235:genetics* / Q000502:physiology*; D005656:Fungal Proteins / Q000235:genetics; D005800:Genes, Fungal; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000096:biosynthesis*; D009154:Mutation; D009492:Neurospora crassa / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development / Q000502:physiology*; D013172:Spores, Fungal / Q000502:physiology; D013696:Temperature
chemical_list: C087405:FRQ protein, Neurospora crassa; D005656:Fungal Proteins; D008055:Lipids; D002794:Choline