title: Expression of alpha tubulin during the dimorphic transition of Paracoccidioides brasiliensis.
abstract: In this study we analyzed the expression of (alpha-tubulin during the dimorphic transition of the human-pathogenic fungus Paracoccidioides brasiliensis. The alpha-tubulin from P. brasiliensis was recognized by a commercially available anti-tubulin antibody and was developmentally regulated during the dimorphic form transition. We detected at least two alpha-tubulin isoforms in the mycelial state and only one isoform in the yeast forms. This finding suggests specific roles for the alpha-tubulin isoforms in P. brasiliensis's yeast and mycelial forms.
authors.affiliation: Laboratório de Biologia Molecular, ICB II, Universidade Federal de Goiás, Goiânia, Brazil.
authors.forename: W P
authors.initials: WP
authors.lastname: Silva
authors.forename: R B
authors.initials: RB
authors.lastname: Soares
authors.forename: R S
authors.initials: RS
authors.lastname: Jesuino
authors.forename: S M
authors.initials: SM
authors.lastname: Izacc
authors.forename: M S
authors.initials: MS
authors.lastname: Felipe
authors.forename: C M
authors.initials: CM
authors.lastname: Soares
mesh_terms: D025282:Mycelium / Q000737:chemistry; D010228:Paracoccidioides / Q000737:chemistry* / Q000254:growth & development / Q000378:metabolism; D020033:Protein Isoforms; D014404:Tubulin / Q000032:analysis* / Q000096:biosynthesis
chemical_list: D020033:Protein Isoforms; D014404:Tubulin