title: [Molecular genetics and clinical application of Rh blood group system].
abstract: The Rh blood group system is one of the most complex and important systems known in humans. It has two homologous structure genes in tandem on 1p34.3-36.1 that encode Rh protein. The Rh protein is a membrane in red blood cell that has 12 transmembrane spans. Rh antigens have many variants; there are three genetic polymorphisms in the RhD-negative individual. The Rh blood group system is of great significance in clinical transfusion and hemolytic disease of the newborn (HDN). Rh PCR genotyping is used for prenatal diagnosis in fetus, but still it has some defects, and in this connection further knowledge about Rh system will be necessary to solve the problem.
authors.affiliation: School of Forensic and Pre-clinical Medicine, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. rechtsme@wcums.edu.cn
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Yiping
authors.initials: Y
authors.lastname: Hou
authors.forename: Jianpin
authors.initials: J
authors.lastname: Tang
mesh_terms: D004899:Erythroblastosis, Fetal / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D012204:Rh-Hr Blood-Group System / Q000097:blood / Q000235:genetics*
chemical_list: D012204:Rh-Hr Blood-Group System