Lipoprotein receptors in the nervous system.
The low-density-lipoprotein (LDL) receptor family is an evolutionarily ancient gene family of structurally closely related cell-surface receptors. Members of the family are involved in the cellular uptake of extracellular ligands and regulate diverse biological processes including lipid and vitamin metabolism and cell-surface protease activity. Some members of the family also participate in cellular signaling and regulate the development and functional maintenance of the nervous system. Here we review the roles of this family of multifunctional receptors in the nervous system and focus on recent advances toward the understanding of the mechanisms by which lipoprotein receptors and their ligands transmit and modulate signals in the brain.
Herz
Joachim
J
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390, USA. Joachim.Herz@UTSouthwestern.edu
Bock
Hans H
HH
D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism; D001921:Brain / Q000254:growth & development / Q000502:physiology*; D021941:Caveolae / Q000378:metabolism; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism; D002490:Central Nervous System / Q000502:physiology*; D002784:Cholesterol / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D053823:Hedgehog Proteins; D007858:Learning / Q000502:physiology; D008024:Ligands; D021962:Membrane Microdomains / Q000378:metabolism; D005810:Multigene Family; D009419:Nerve Tissue Proteins; D021381:Protein Transport / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D011973:Receptors, LDL / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D000091042:Reelin Protein; D012697:Serine Endopeptidases; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D001057:Apolipoproteins E; D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D053823:Hedgehog Proteins; D008024:Ligands; D009419:Nerve Tissue Proteins; D011518:Proto-Oncogene Proteins; D011973:Receptors, LDL; D016194:Receptors, N-Methyl-D-Aspartate; D000091042:Reelin Protein; D015534:Trans-Activators; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D002784:Cholesterol; D012697:Serine Endopeptidases