ZNC(C)PR Induces Phosphorylation of CREB in Rat Hippocampus.
ZNC(C)PR can facilitate the learning and memory in rat. Transgenic experiments have revealed that long-term memory depended on cyclic AMP-response element binding protein, CREB. CREB phosphorylation at serine-133 is essential for it's transcriptional activity. Here, it was demonstrated that ZNC(C)PR could induce CREB phosphorylation at serine-133 in both rat hippocampus and rat hippocampus slices. ZDC(C)PR antagnist of ZNC(C)PR , PTX(inhibitor of G(o)/G(I) protein coupled receptor), GF109203x(inhihitor of PKC), PD98059( inhibitor of MAPK ) but not KN-62(inhibitor of CaMKII) could inhibit the phosphorylation of CREB induced by ZNC(C)PR.
Dong
Ming
M
Shanghai Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai 200031, China. duyc@sunm.shcnc.ac.cn
Xiong
Ying
Y
Xu
Kan-Yan
KY
Du
Yu-Cang
YC