title: Effect of irrigating solution and calcium hydroxide root canal dressing on the repair of apical and periapical tissues of teeth with periapical lesion.
abstract: The objective of this study was to evaluate the apical and periapical repair after endodontic treatment of teeth with pulp necrosis and a chronic periapical lesion in dogs. Seventy-two root canals from four mongrel dogs were submitted to biomechanical preparation, using 5.25% sodium hypochlorite or 2% chlorhexidine digluconate as the irrigating solution. The root canals were subsequently either filled immediately with Sealapex, using active lateral gutta-percha condensation, or a calcium hydroxide root canal dressing was applied for 15 days before filling with Sealapex. After 210 days, the animals were killed by anesthetic overdose, and the obtained histological sections were stained with hematoxylin and eosin for optical microscopic analysis of apical and periapical repair. There was better histological repair in the groups with the root canal dressing (p < 0.05) than the groups with immediate obturation. Comparing the immediate obturation groups, irrigation with chlorhexidine solution resulted in better repair than sodium hypochlorite.
authors.affiliation: Department of Endodontics, School of Dentistry of Araraquara, University of the State of São Paulo, UNESP, Brazil.
authors.forename: Mário
authors.initials: M
authors.lastname: Tanomaru Filho
authors.forename: Mario Roberto
authors.initials: MR
authors.lastname: Leonardo
authors.forename: Léa Assed Bezerra
authors.initials: LA
authors.lastname: da Silva
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000473:pathology; D002126:Calcium Hydroxide / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000627:therapeutic use; D003790:Dental Pulp Necrosis / Q000628:therapy; D004195:Disease Models, Animal; D004202:Disinfectants / Q000627:therapeutic use; D004285:Dogs; D005260:Female; D006171:Gutta-Percha / Q000627:therapeutic use; D008297:Male; D010483:Periapical Diseases / Q000628:therapy*; D010485:Periapical Periodontitis / Q000473:pathology; D010486:Periapical Tissue / Q000187:drug effects / Q000473:pathology; D010513:Periodontal Ligament / Q000473:pathology; D012387:Root Canal Filling Materials / Q000627:therapeutic use*; D012388:Root Canal Irrigants / Q000627:therapeutic use*; D012389:Root Canal Obturation / Q000295:instrumentation / Q000379:methods; D018915:Root Canal Preparation; D012390:Root Canal Therapy; D012391:Root Resorption / Q000473:pathology; D012459:Salicylates / Q000627:therapeutic use; D012973:Sodium Hypochlorite / Q000627:therapeutic use; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D013997:Time Factors; D014945:Wound Healing
chemical_list: D004202:Disinfectants; D012387:Root Canal Filling Materials; D012388:Root Canal Irrigants; D012459:Salicylates; C055601:Sealapex; D006171:Gutta-Percha; D012973:Sodium Hypochlorite; D002126:Calcium Hydroxide; D002710:Chlorhexidine