title: The first synthetic receptor for the RGD sequence.
abstract: [structure: see text] The combination of an optimized arginine receptor unit with a semirigid linker carrying a strategically placed primary ammonium group leads to the first synthetic RGD receptor. It binds to the free RGD peptide as well as to cyclo(RGDfV) in water with association constants around 1000 M(-1). RGD mimetics such as benzamidine 6 are not recognized, rendering the new host a prototype of a new class of receptors selective for the true RGD sequence in peptides.
authors.affiliation: Fachbereich Chemie, Universität Marburg, Hans-Meerwein-Strasse, 35032 Marburg, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Rensing
authors.forename: Thomas
authors.initials: T
authors.lastname: Schrader
mesh_terms: D006860:Hydrogen Bonding; D016023:Integrins / Q000037:antagonists & inhibitors / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D018716:Molecular Mimicry; D015394:Molecular Structure; D009842:Oligopeptides / Q000378:metabolism*; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors / Q000737:chemistry*; D018000:Receptors, Peptide / Q000037:antagonists & inhibitors / Q000737:chemistry*; D013379:Substrate Specificity; D017186:Titrimetry
chemical_list: D016023:Integrins; D008024:Ligands; D009842:Oligopeptides; D010446:Peptide Fragments; D011971:Receptors, Immunologic; D018000:Receptors, Peptide; C051382:arginyl-glycyl-aspartic acid directed cell adhesion receptor; C047981:arginyl-glycyl-aspartic acid