title: DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology.
abstract: Dendritic cells (DC) are present in essentially every tissue where they operate at the interface of innate and acquired immunity by recognizing pathogens and presenting pathogen-derived peptides to T cells. It is becoming clear that not all C-type lectins on DC serve as antigen receptors recognizing pathogens through carbohydrate structures. The C-type lectin DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells. Here we discuss the carbohydrate/protein recognition profile and other features of DC-SIGN that contribute to the potency of DC to control immunity.
authors.affiliation: Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, The Netherlands.
authors.forename: Teunis B H
authors.initials: TB
authors.lastname: Geijtenbeek
authors.forename: Anneke
authors.initials: A
authors.lastname: Engering
authors.forename: Yvette
authors.initials: Y
authors.lastname: Van Kooyk
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules; D003713:Dendritic Cells / Q000502:physiology*; D006801:Humans; D037102:Lectins / Q000502:physiology*; D037181:Lectins, C-Type; D051379:Mice; D011946:Receptors, Antigen / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D015728:Receptors, HIV / Q000502:physiology; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D037102:Lectins; D037181:Lectins, C-Type; D011946:Receptors, Antigen; D011956:Receptors, Cell Surface; D015728:Receptors, HIV; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin