title: Prevention of pregnancy in the dog with a combination of prostaglandin F2 alpha and bromocriptine.
abstract: Fifteen mated bitches were given prostaglandin F2 alpha (PGF2 alpha) [250 micrograms/kg body weight] and bromocriptine (10 micrograms/kg BW) twice daily from days 6 to 10 of diestrus. Progesterone concentrations declined during treatment. None of the bitches whelped. Daily treatment with PGF2 alpha and bromocriptine for 5 d appears to induce luteolysis and prevent early pregnancy.
authors.affiliation: Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4.
authors.forename: Colin W
authors.initials: CW
authors.lastname: Palmer
authors.forename: Klaas
authors.initials: K
authors.lastname: Post
mesh_terms: D000019:Abortifacient Agents / Q000494:pharmacology*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D003267:Contraception / Q000379:methods / Q000662:veterinary*; D003338:Corpus Luteum / Q000187:drug effects*; D015237:Dinoprost / Q000494:pharmacology*; D004285:Dogs / Q000502:physiology*; D004359:Drug Therapy, Combination; D005260:Female; D006727:Hormone Antagonists / Q000494:pharmacology*; D011247:Pregnancy; D013997:Time Factors
chemical_list: D000019:Abortifacient Agents; D006727:Hormone Antagonists; D001971:Bromocriptine; D015237:Dinoprost