Higher order wavefront aberrations of cornea and magnitude of refractive correction in laser in situ keratomileusis.
OBJECTIVE
To assess the relation between magnitude of refractive correction and changes in higher order wavefront aberrations of the cornea after laser in situ keratomileusis.


METHODS
Prospective, consecutive, nonrandomized comparative trial (self-controlled).


METHODS
One hundred eyes of 53 patients with myopia (-2.0 to -13.0 diopters) were included.


METHODS
Laser in situ keratomileusis was performed. Videokeratography measurements were conducted before and 1 month after surgery.


METHODS
The videokeratography data were used to calculate the higher order wavefront aberrations of the cornea for both small (3 mm) and large (6 mm) pupils.


RESULTS
For a 3-mm pupil, the surgery significantly increased coma-like (2.4 +/- 1.3-fold, P < 0.001, paired t test) and spherical-like (1.8 +/- 0.9-fold, P < 0.001) aberrations. For a 6-mm pupil, both coma-like (4.4 +/- 3.3-fold, P < 0.001) and spherical-like (9.4 +/- 5.2-fold, P < 0.001) aberrations were significantly increased by surgery. The amount of achieved correction showed significant correlations with the changes in coma-like (Pearson correlation coefficient r = 0.446, P < 0.001) and spherical-like (r = 0.348, P < 0.001) aberrations for a 3-mm pupil, and coma-like (r = 0.566, P < 0.001) and spherical-like (r = 0.693, P < 0.001) aberrations for a 6-mm pupil. The eyes that lost 2 or more lines of baseline spectacle-corrected visual acuity showed significantly larger induced increases in coma-like (P = 0.003, Mann-Whitney U test) and spherical-like (P = 0.009) aberrations for a 3-mm pupil than those that either improved or remained within 1 line of spectacle-corrected visual acuity


CONCLUSIONS
Laser in situ keratomileusis, performed using the current algorithms, increases higher order wavefront aberrations of the cornea, dependent on the amount of refractive correction.
Oshika
Tetsuro
T
Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan.
Miyata
Kazunori
K
Tokunaga
Tadatoshi
T
Samejima
Tomokazu
T
Amano
Shiro
S
Tanaka
Sumiyoshi
S
Hirohara
Yoko
Y
Mihashi
Toshifumi
T
Maeda
Naoyuki
N
Fujikado
Takashi
T
D000328:Adult; D000465:Algorithms; D003315:Cornea / Q000503:physiopathology*; D019781:Corneal Topography; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology