title: [Sibling cases of nephritis resembling membranoproliferative glomerulonephritis].
abstract: We have experienced rare cases of membranoproliferative glomerulonephritis (MPGN)-like nephritis, which was seen in siblings. Both the brothers had asymptomatic hematuria and proteinuria at an age before 10, 7 and 4 years old, respectively. Renal biopsy revealed proliferative glomerulonephritis, resembling MPGN type III. The family history showed that their father and grandfather suffered from end-stage renal disease, suggesting that MPGN seen in the present sibling cases is hereditary. A review of the literature revealed that familial MPGN is rare, that most of the cases have urinary abnormalities at an age of less than 10 years, and that male preponderance is seen in familial MPGN.
authors.affiliation: Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ueda
authors.forename: Eiji
authors.initials: E
authors.lastname: Isimura
authors.forename: Senji
authors.initials: S
authors.lastname: Okuno
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Maekawa
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Izumotani
authors.forename: Masao
authors.initials: M
authors.lastname: Kim
authors.forename: Naoki
authors.initials: N
authors.lastname: Matsumoto
authors.forename: Shinya
authors.initials: S
authors.lastname: Fukumoto
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Imanishi
authors.forename: Masanori
authors.initials: M
authors.lastname: Emoto
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shoji
authors.forename: Hideki
authors.initials: H
authors.lastname: Wanibuchi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Inaba
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nishizawa
mesh_terms: D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005192:Family Health; D015432:Glomerulonephritis, Membranoproliferative / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D009393:Nephritis / Q000235:genetics* / Q000473:pathology