Chromatin as a eukaryotic template of genetic information.
In eukaryotes, chromatin is essential for heredity. Chromatin architecture is sometimes "epistatic" over the DNA and imparts a different heritable state to the same DNA sequence or the same functional state to unrelated DNA sequences. This has been documented recently in a wide variety of studies focused on regulation of the yeast mating type, the function of Polycomb and trithorax group proteins, the specification of eukaryotic centromeres and neocentromeres, and genomic imprinting.
Cavalli
Giacomo
G
Institut de Génétique Humaine-CNRS, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France. Giacomo.Cavalli@igh.cnrs.fr
D000818:Animals; D002503:Centromere / Q000235:genetics; D002843:Chromatin / Q000235:genetics*; D019976:Cloning, Organism; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins / Q000502:physiology; D005057:Eukaryotic Cells / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D018506:Gene Expression Regulation, Plant; D018392:Genomic Imprinting; D051379:Mice; D008957:Models, Genetic; D053652:Nuclear Transfer Techniques; D012568:Schizosaccharomyces / Q000235:genetics; D013698:Templates, Genetic
D002843:Chromatin; D029721:Drosophila Proteins