Cassava diet--a cause for mucopolysaccharidosis?
Studies were carried out to determine the changes in glycosaminnoglycan (GAG) metabolism in rats fed cassava with varying cyanoglucoside levels and two levels of protein. Results indicated that there was an enhancement in the level of total and individual GAG with a corresponding reduction in the activity of enzymes involved in the degradation of glycosaminoglycan. These changes were significant for rats given a cassava diet (raw and boiled cassava) and low protein. The changes in total and individual GAG and the decrease in the activity of degrading enzymes was more for high cyanide (raw cassava) groups compared with other groups showing that consumption of untreated cassava is an additive factor for the promotion of mucopolysaccharidosis.
Sreeja
V G
VG
Department of Biochemistry, University of Kerala, Kariyavattom, Trivandrum, India.
Leelamma
S
S
D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D002402:Cathepsin D / Q000378:metabolism; D003296:Cooking; D003486:Cyanides / Q000633:toxicity; D004044:Dietary Proteins / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005511:Food Handling / Q000379:methods; D005966:Glucuronidase / Q000378:metabolism; D006025:Glycosaminoglycans / Q000008:administration & dosage* / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008112:Liver Glycogen / Q000032:analysis; D008297:Male; D002365:Manihot / Q000009:adverse effects*; D009083:Mucopolysaccharidoses / Q000209:etiology* / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
D003486:Cyanides; D004044:Dietary Proteins; D006025:Glycosaminoglycans; D008112:Liver Glycogen; D001192:Arylsulfatases; D005966:Glucuronidase; D001619:beta-N-Acetylhexosaminidases; D002402:Cathepsin D