Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae).
Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20alpha-hydroxy-tingenone showed high activity, epikatonic acid was less active, while populnilic and populninic acids were inactive against the trypanosome of the subgenus Schizotrypanum tested. Benzonidazole, nifurtimox, ketoconazole and primaquine presented a remarkable dose-dependent inhibitory effect reaching practically to a total growth inhibition of the parasite at the end of incubation time. The trypanosome tested appear to be a suitable model for preliminary screen for anti T. (S.) cruzi compounds.
Duarte
Lucienir Pains
LP
Núcleo de Estudo de Plantas Medicinais, Departamento de Química, UFMG, MG, Brasil.
Vieira Filho
Sidney Augusto
SA
Silva
Grácia Divina de Fátima
GD
de Sousa
José Rego
JR
Pinto
Artur da Silveira
Ada S
D000818:Animals; D029753:Celastraceae / Q000737:chemistry*; D021261:Parasitic Sensitivity Tests; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D014315:Triterpenes; D014344:Trypanocidal Agents