Lysophospholipid regulation of mononuclear phagocytes.
Blood monocytes and tissue macrophages derived from monocyte differentiation in tissues are central elements of innate immunity in host defense against numerous pathogens and other challenges. These mononuclear phagocytes also participate in wound healing and normal tissue remodeling in development and growth. Pathological perversion of their physiological roles leads to participation of mononuclear phagocytes in fibrosing diseases including granulomatous disorders, chronic inflammation typical of arthritis, and atherosclerosis. Lysophospholipids, including lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are platelet-derived lipid growth factors considered to participate in leukocyte differentiation and activation. This section summarizes our recent observations of the effects of lysophospholipids on mononuclear phagocytes.
Lee
Hsinyu
H
Department of Zoology, National Taiwan University, Taipei, Taiwan, ROC. hsinyulee@yahoo.com
Liao
Jia Jun
JJ
Graeler
Markus
M
Huang
Mei Chuan
MC
Goetzl
Edward J
EJ
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology*; D010586:Phagocytes / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D008246:Lysophospholipids; D011956:Receptors, Cell Surface