Dexamethasone inhibition of the cellular immune response of Drosophila melanogaster against a parasitoid.
Host larvae of Drosophila melanogaster injected with the eicosanoid biosynthesis inhibitor, dexamethasone, prior to parasitization by the wasp Leptopilina boulardi, exhibited significantly reduced rates of melanotic encapsulation in comparison with control and saline-injected larvae. The results of this investigation suggest that prostaglandins and other eicosanoids are involved as cell-signaling molecules in the hemocytic encapsulation reaction of D. melanogaster larvae.
Carton
Yves
Y
Laboratoire Populations, Genetique et Evolution, CNRS, Gif-sur-Yvette, France.
Frey
Francoise
F
Stanley
David W
DW
Vass
Emily
E
Nappi
Anthony J
AJ
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000276:immunology / Q000494:pharmacology*; D003907:Dexamethasone / Q000276:immunology / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000187:drug effects / Q000276:immunology* / Q000469:parasitology; D014863:Wasps / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone