title: Ets-2 overexpression contributes to progression of pancreatic adenocarcinoma.
abstract: Ets-2, a transcriptional factor, has been linked to carcinoma progression but in-depth studies on its expression in human carcinoma have not been done. The present study investigated ets-2 expression in pancreatic adenocarcinoma. The ets-2 labeling index (LI) in normal pancreatic duct and pancreatic adenocarcinoma averaged 33.1+/-8.4 and 43.1+/-18.6, respectively. No statistical significance was found between the LI of normal duct and that of carcinoma with low biological aggressiveness. However, in cases with highly aggressive phenotypes such as stage IV, moderate or poor differentiation, lymph node metastasis, larger size, vascular invasion, lymphatic invasion, perineural invasion, retropancreatic invasion and capsular invasion, the ets-2 LI was significantly higher than in normal ducts and in cases with lower biological aggressiveness. Also, ets-2 transfected pancreatic carcinoma cells, when injected into athymic mice caused the formation of large tumors. These results suggest that ets-2 plays a role in the progression of pancreatic adenocarcinoma predominantly in the late phase.
authors.affiliation: Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan. ito01@kuma-h.or.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Eiji
authors.initials: E
authors.lastname: Miyoshi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takeda
authors.forename: Masato
authors.initials: M
authors.lastname: Sakon
authors.forename: Shinji
authors.initials: S
authors.lastname: Ihara
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsujimoto
authors.forename: Nariaki
authors.initials: N
authors.lastname: Matsuura
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000328:Adult; D000368:Aged; D000818:Animals; D002454:Cell Differentiation; D018450:Disease Progression; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology; D010179:Pancreas / Q000378:metabolism; D010183:Pancreatic Ducts / Q000378:metabolism / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors