[Pulmonary problems associated with lymphoplasmacytic lymphoma (Waldenström's macroglobulinemia)].
A 62-year-old man, known for some years due to lymphoplasmacytic lymphoma, was admitted with progressive dyspnoea. Multiple lung infiltrates were found upon X-ray examination. Because of the suspicion of an infection, a bronchoscopy with bronchoalveolar lavage was performed. No infectious cause could be established. Upon cytological examination, a highly increased level of kappa-positive B-lymphoid cells was found, as is seen in cases of lymphoplasmacytic lymphoma (Waldenström's macroglobulinaemia). Following chemotherapy, the dyspnoea lessened and the pulmonary infiltrates disappeared. In patients with a lymphoproliferative disorder, pulmonary infiltrates due to infection are found relatively frequently. This case report highlights a rare complication of the disease, namely pulmonary infiltrates caused by infiltration of lymphoplasmacytic cells, emphasising the importance of cytological examination of broncho-alveolar lavage fluid.
Aerts
J G J V
JG
Afd. Longziekten, Academisch Ziekenhuis Rotterdam-Daniel den Hoed Kliniek, Rotterdam.
de Jongh
F
F
van Iperen
C E
CE
Lam
K H
KH
Hoogsteden
H C
HC
van Meerbeeck
J P A M
JP
D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D004417:Dyspnea / Q000209:etiology*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
Longklachten bij lymfoplasmocytair lymfoom (ziekte van Waldenström).