Hyper-IgM syndrome with systemic tuberculosis.
A 33-y-old man with Hyper-IgM syndrome developed a severe tuberculous disease complicated by pleuritis and spondylitis. An abnormally decreased CD4/CD8 ratio, decreased CD4 + T-cell count and depressed natural killer cell activity implicated a coexistent cell-mediated immunodeficiency. To our knowledge, this is the first detailed report of tuberculosis associated with Hyper-IgM syndrome.
Ito
Isao
I
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan. isaoito@kuhp.kyoto-u.ac.jp
Ishida
Tadashi
T
Hashimoto
Toru
T
Arita
Machiko
M
Osawa
Makoto
M
Mishima
Michiaki
M
Nonoyama
Shigeaki
S
D000328:Adult; D016516:CD4-CD8 Ratio; D006801:Humans; D007075:Immunoglobulin M; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000473:pathology; D008297:Male; D010998:Pleurisy / Q000150:complications; D013166:Spondylitis / Q000150:complications; D014376:Tuberculosis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000473:pathology
D007075:Immunoglobulin M