Field population-based blocking treatment of esophageal epithelia dysplasia.
OBJECTIVE
To confirm the value of blocking treatment by zenshengping (ZSP), a Chinese herb composite, and Riboflavin for esophageal epithelia dysplasia cases screened out in high risk area in northern china by exfoliative balloon cytology (EBC), so to reduce the incidence rate of esophageal cancer(EC).


METHODS
Esophageal epithelium dysplasia cases including mind esophageal epithelium dysplasia (MEED), stage one severe esophageal epithelium dysplasia (SEED I), and stage two severe esophageal epithelium dysplasia (SEED II) were screened out from people aged 40 years and older in the high risk area of Chixian. These cases were randomly divided into a treatment and control group. Subjects in the treatment and control groups took ZSP, riboflavin, and placebo daily for three years. EC cases registered by cancer registry and identified by EBC re-screening in the treatment and control groups were used to calculate incidence and blocking rates to demonstrate the effects of blocking medication.


RESULTS
It was found that 31.92% and 24.15% of people aged 40 years and older in Cixian could been diagnosed as MEED and SEED cases. The severity of dysplasia increased with age. ZSP had blocked EC occurrence by 47.79% after 3 year medication among the SEED cases.


CONCLUSIONS
ZSP can block the development from SEED I and SEED II to EC by 47.79%. Efforts should be made to screen and treat dysplasia cases in people aged 40 years and older in high risk areas to reduce the mortality figures.
Hou
Jun
J
Hebei Cancer Institute, Jiankanglu 5, Shijiazhuang 050011, China.
Lin
Pei-Zhong
PZ
Chen
Zhi-Feng
ZF
Ding
Zhen-Wei
ZW
Li
Shao-Sheng
SS
Men
Fan-Shu
FS
Guo
Li-Ping
LP
He
Yu-Tong
YT
Qiao
Chui-Yun
CY
Guo
Chui-Lan
CL
Duan
Jian-Ping
JP
Wen
Deng-Gui
DG
D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D004947:Esophagus / Q000187:drug effects* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011230:Precancerous Conditions / Q000453:epidemiology / Q000517:prevention & control
D004365:Drugs, Chinese Herbal