[Drug delivery systems to target the anterior segment of the eye: fundamental bases and clinical applications].
The development of new drug delivery systems to target the anterior segment of the eye may offer many advantages: to increase the biodisponibility of the drug, to allow the penetration of drug that cannot be formulated as solutions, to obtain constant and sustained drug release, to achieve higher local concentrations without systemic effects, to target more specifically one tissue or cell type, to reduce the frequency of instillation and therefore increase the observance and comfort of the patient while reducing side effects of frequent instillation. Several approaches are developed, aiming to increase the corneal contact time by modified formulation or reservoir systems, or by increasing the tissue permeability using iontophoresis. To date, no ocular drug delivery system is ideal for all purposes. To maximize treatment efficacy, careful evaluation of the specific pathological condition, the targeted Intraocular tissue and the location of the most severe pathology must be made before selecting the method of delivery most suitable for each individual patient.
Behar-Cohen
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INSERM U450, 15, rue de l'Ecole de médecine 75006 Paris, France.
D000869:Anterior Eye Segment; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007322:Instillation, Drug; D014018:Tissue Distribution
Systèmes de délivrance des médicaments pour le segment antérieur: bases fondamentales et applications cliniques.