title: Studies on the psychopharmacological activities of Rumex nepalensis Spreng. root extract in rats and mice.
abstract: The methanol extract of Rumex nepalensis Spreng. (Family - Polygonaceae) was assessed for different psychopharmacological activities in rats and mice by evaluation of general behaviour, exploratory behaviour, muscle relaxant activity and phenobarbitone sodium-induced sleeping time. The extract at doses 200 mg/kg and above exhibited a reduction in spontaneous activity (general behavioural profile), a decrease in exploratory behavioural pattern in the Y-maze and Head-dip tests, a reduction in muscle relaxant activity in rotarod, 30 degrees inclined screen and traction tests, and also potentiated phenobarbitone sodium-induced sleeping time.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
authors.forename: Lopamudra
authors.initials: L
authors.lastname: Ghosh
authors.forename: G
authors.initials: G
authors.lastname: Arunachalam
authors.forename: T
authors.initials: T
authors.lastname: Murugesan
authors.forename: M
authors.initials: M
authors.lastname: Pal
authors.forename: B P
authors.initials: BP
authors.lastname: Saha
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000494:pharmacology*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D010634:Phenobarbital; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018517:Plant Roots; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D031804:Rumex; D012890:Sleep / Q000187:drug effects; D014143:Traction
chemical_list: D009125:Muscle Relaxants, Central; D010936:Plant Extracts; D011619:Psychotropic Drugs; D010634:Phenobarbital