title: S-propyl cysteine reduces the secretion of apolipoprotein B100 and triacylglycerol by HepG2 cells.
abstract: A number of sulfur-containing amino acids and peptides are found in allium plants such as onion and garlic that have physiologic functions. In HepG2 cells, S-propyl cysteine decreased the secretion of apolipoprotein B100. The compound reduced the secretion of newly synthesized triacylglycerol and cholesterols from radiolabeled acetate. We associated the decrease of apolipoprotein B100 secretion to the length of the acyl-chain of the sulfur-containing amino acids. The present study suggests that foods containing S-propyl cysteine including onions have beneficial effects.
authors.affiliation: Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, Saga 840-8502, Japan
authors.forename: Seo-young
authors.initials: SY
authors.lastname: Han
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.forename: Takahiko
authors.initials: T
authors.lastname: Anno
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Yanagita
mesh_terms: D000490:Allium / Q000737:chemistry*; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D003470:Culture Media; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D010936:Plant Extracts / Q000494:pharmacology; D014280:Triglycerides / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D003470:Culture Media; D010936:Plant Extracts; D014280:Triglycerides; C028742:S-propylcysteine; D002784:Cholesterol; D003545:Cysteine