[Acute tubular necrosis with acute renal failure during the first month of treatment with 5-amino-salicylate (Pentasa(R))].
We report a case of acute tubular necrosis in a patient with Crohn's disease treated by 5-amino-salicylate (Pentasa(R)) since one month. Normalization of renal biological parameters occurred rapidly after treatment withdrawal. This case raises the question of the optimal modalities of monitoring of renal function during treatment with 5-amino-salicylate.
Beaulieu
Sandrine
S
Service d'Hépato-Gastroentérologie, Centre Hospitalier Intercommunal Poissy/Saint Germain, 10, rue du champ Gaillard, 78303 Poissy Cedex, France.
Rocher
Philippe
P
Hillion
Daniel
D
Nochy
Dominique
D
Tennenbaum
Ruth
R
Vitte
René-Louis
RL
Eugène
Claude
C
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology*; D008297:Male; D019804:Mesalamine / Q000009:adverse effects*; D008875:Middle Aged; D009336:Necrosis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine
Insuffisance rénale aiguë par nécrose tubulaire aiguë au cours du premier mois de traitement par l'acide 5-amino-salicylique (Pentasa(R)).