DMLE+: Bayesian linkage disequilibrium gene mapping.
CONCLUSIONS
The program DMLE+ allows Bayesian inference of the location of a gene carrying a mutation influencing a discrete trait (such as a disease) and/or other parameters of interest (such as mutation age) based on the observed linkage disequilibrium at multiple genetic markers. DMLE+ uses either individual marker genotypes, or haplotypes, integrates over uncertain population allele frequencies, and can incorporate prior information about gene location from an annotated human genome sequence.


BACKGROUND
DMLE+ is available in both Windows GUI and portable UNIX command line versions at http://dmle.org.
Reeve
Jeff P
JP
Department of Medical Genetics, University of Alberta, 8-39 Medical Sciences Building, Edmonton, Canada.
Rannala
Bruce
B
D001499:Bayes Theorem; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D019295:Computational Biology; D005819:Genetic Markers; D015894:Genome, Human; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D009154:Mutation; D011336:Probability; D012984:Software
D005819:Genetic Markers