Efficacy of liposomal amphotericin B in treatment of systemic murine fusariosis.
We have compared the activities of liposomal amphotericin B (LAMB) at 3, 5, 10, and 20 mg/kg/day and amphotericin B deoxycholate (AMB) at 1.5 and 2.5 mg/kg/day in a murine systemic infection by Fusarium verticillioides. Survival was improved by all treatments except AMB at 1.5 mg/kg/day. The tissue burden in liver was reduced by LAMB at all dosages and by AMB at 2.5 mg/kg/day. The two highest dosages of LAMB showed significant reductions in the spleen.
Ortoneda
Montserrat
M
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut and Institut d'Estudis Avançats, Universitat Rovira i Virgili, 43201 Reus, Spain.
Capilla
Javier
J
Pastor
Francisco J
FJ
Pujol
Isabel
I
Guarro
Josep
J
D000666:Amphotericin B / Q000008:administration & dosage*; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D005670:Fusarium / Q000302:isolation & purification; D007668:Kidney / Q000382:microbiology; D008081:Liposomes; D008099:Liver / Q000382:microbiology; D008297:Male; D051379:Mice; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D013154:Spleen / Q000382:microbiology
D000935:Antifungal Agents; D008081:Liposomes; D000666:Amphotericin B