title: Location and clinical implications of high-degree atrioventricular block during dipyridamole infusion: a case report.
abstract: We describe a patient with bifascicular block, who developed transient high-degree atrioventricular block during dipyridamole infusion. This patient was subsequently found to have significant His-Purkinje disease at electrophysiology study, and underwent permanent pacemaker implantation. Spontaneous atrioventricular block was documented during follow-up. This case report raises the issue of dipyridamole safety in patients with intraventricular conduction defects, and contributes an additional mechanism to the possible explanation of dipyridamole-induced atrioventricular block.
authors.affiliation: SUNY-Downstate Medical Center, 450 Clarkson Avenue, Box 1199, Brooklyn, NY 11203, USA.
authors.forename: Mazen
authors.initials: M
authors.lastname: Alakhras
authors.forename: Duccio
authors.initials: D
authors.lastname: Baldari
authors.forename: Nabil
authors.initials: N
authors.lastname: El-Sherif
authors.forename: Gioia
authors.initials: G
authors.lastname: Turitto
mesh_terms: D000368:Aged; D004176:Dipyridamole / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000139:chemically induced*; D006801:Humans; D006973:Hypertension / Q000150:complications; D010003:Osteoarthritis / Q000150:complications; D011690:Purkinje Fibers / Q000187:drug effects / Q000473:pathology
chemical_list: D004176:Dipyridamole