New ketosteroids from the red alga Hypnea musciformis.
The dichloromethane/methanol extract from the red alga Hypnea musciformis exhibited PPE elastase inhibition. A diketosteroid, the 20-hydroxy-5alpha-cholest-22-ene-3,6-dione was responsible for this activity. Two new steroids were isolated, 2 was assigned as the 6alpha-hydroxy-cholest-4-ene-3-one and 3 as the 6alpha-hydroxy-cholest-4,22-diene-3-one. The structures were assigned mainly on the basis of 1H and 13C NMR experiments.
Bultel-Poncé
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Laboratoire de Chimie des Substances Naturelles associé au CNRS, Muséum National d'Histoire Naturelle, 63 rue Buffon, 75005 Paris, France. bultel@mnhn.fr
Etahiri
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S
Guyot
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M
D002850:Chromatography, Gel; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007664:Ketosteroids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D000461:Rhodophyta / Q000737:chemistry*; D013057:Spectrum Analysis
D004791:Enzyme Inhibitors; D007664:Ketosteroids; D010196:Pancreatic Elastase