Phosphorylation of Helicobacter pylori CagA in patients with gastric ulcer and gastritis.
The effects of Helicobacter pylori infection are strongly associated with chronic gastritis, gastric and duodenal ulcer, gastric cancer, and MALT lymphoma. The microorganism has been classified as a type I carcinogen by the World Health Organization. Varying clinical results from H. pylori infection are believed due, in part, to differences in virulence among species. The cag pathogenicity island is a complex of virulent genes and a coding region for the type IV phosphorylated secretion system. Through this system, many virulent gene products or proteins are phosphorylated into the host cells. This study demonstrated the positive CagA-phosphorylation effect of H. pylori in patients with chronic gastritis and benign gastric ulcer and revealed significantly different rates of CagA phosphorylation between these two diseases (P<.05).
Cheng
Ken-Sheng
KS
Department of Internal Medicine, China Medical College Hospital, Taichung, Taiwan.
Lu
Min-Chi
MC
Tang
Hui-Ling
HL
Chou
Fu-Tsan
FT
D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D003470:Culture Media; D005260:Female; D005756:Gastritis / Q000382:microbiology*; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D013276:Stomach Ulcer / Q000382:microbiology*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D003470:Culture Media; C080866:cagA protein, Helicobacter pylori