title: In vitro susceptibility to quinolones of Francisella tularensis subspecies tularensis.
abstract: Francisella tularensis is a potent pathogen and a possible bioterrorism agent, for which quinolones offer promising new therapeutic options. There are, however, no data on the susceptibility to quinolones of natural isolates of F. tularensis tularensis, the highly virulent North American subspecies. In the present study, 8 isolates of F. tularensis tularensis, originating from 8 different states of the USA, and 16 US isolates of F. tularensis holarctica were tested. All 24 isolates showed MIC values < or = 0.125 mg/l to 6 different quinolones. Against ciprofloxacin, the predominant quinolone used to date in therapy against subspecies holarctica, MIC values were consistently < or = 0.064 mg/l. Thus quinolones seem to be promising options for the treatment of tularemia, including cases caused by the highly virulent subspecies F. tularensis tularensis.
authors.affiliation: Department of Infectious Diseases, Umeå University, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Johansson
authors.forename: Sandra K
authors.initials: SK
authors.lastname: Urich
authors.forename: May C
authors.initials: MC
authors.lastname: Chu
authors.forename: Anders
authors.initials: A
authors.lastname: Sjöstedt
authors.forename: Arne
authors.initials: A
authors.lastname: Tärnvik
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D005604:Francisella tularensis / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D014406:Tularemia / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones