title: Flagellin perception: a paradigm for innate immunity.
abstract: There are surprising similarities between how animals and plants perceive pathogens. In animals, innate immunity is based on the recognition of pathogen-associated molecular patterns. This is mediated by the Toll-like receptor (TLR) family, which rapidly induce the innate immunity response, a first line of defence against infectious disease. Plants have highly sensitive perception systems for general elicitors and they respond to these stimuli with a defence response. One of these general elicitors is flagellin, the main component of the bacterial flagellum. Genetic analysis in Arabidopsis has shown that FLS2, which encodes a receptor-like kinase, is essential for flagellin perception. FLS2 shares homology with the TLR family, and TLR5 is responsible for flagellin perception in mammals.
authors.affiliation: Sección de Biotecnología, IDR, Campus Universitario s/n, E-02071 Albacete, Spain. mlgomez@idr-ab.uclm.es
authors.forename: Lourdes
authors.initials: L
authors.lastname: Gómez-Gómez
authors.forename: Thomas
authors.initials: T
authors.lastname: Boller
mesh_terms: D000818:Animals; D029681:Arabidopsis Proteins; D001419:Bacteria / Q000235:genetics / Q000254:growth & development; D029721:Drosophila Proteins; D019143:Evolution, Molecular; D005408:Flagellin / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D005658:Fungi / Q000235:genetics / Q000254:growth & development; D007113:Immunity, Innate / Q000276:immunology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D010935:Plant Diseases / Q000235:genetics / Q000382:microbiology; D010944:Plants / Q000235:genetics / Q000382:microbiology*; D011494:Protein Kinases / Q000235:genetics / Q000502:physiology; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors
chemical_list: D029681:Arabidopsis Proteins; D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors; D005408:Flagellin; D011494:Protein Kinases; C411853:FLS2 protein, Arabidopsis