title: [Persistent polyclonal B-cell lymphocytosis].
abstract: Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare and recently described entity. PPBL is diagnosed predominantly but not exclusively in women, usually smokers and is characterized by a moderate, chronic and absolute lymphocytosis (> 4 x 109/L). Peripheral blood examination show in all cases atypical binucleated lymphocytes. A polyclonal serum IgM is also associated and HLA-DR7 expression is present in most cases. The B cells are polyclonal with kappa and lambda light-chain expression. No clonal rearrangement of immunoglobulin heavy chain genes is observed. Finally, +i(3q) is a recurrent chromosomal abnormality and detected in 77% of cases with premature chromosome condensation in 50% and both abnormalities in 41% of cases. The benign clinical course of PPBL and lack of biological evolution in the majority of cases suggest that recognition is so important that aggressive therapy could be avoided.
authors.affiliation: Laboratoire d'hématologie, CHU Côte-de-Nacre, 14000 Caen, France.
authors.lastname: Troussard
authors.forename: H
authors.initials: H
authors.lastname: Mossafa
authors.forename: G
authors.initials: G
authors.lastname: Flandrin
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D015322:Gene Rearrangement, B-Lymphocyte; D005803:Genes, Immunoglobulin; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D007146:Immunoglobulin lambda-Chains / Q000097:blood; D008218:Lymphocytosis / Q000235:genetics* / Q000276:immunology*; D008297:Male; D012727:Sex Characteristics
chemical_list: D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains
vernacular_title: Lymphocytose polyclonale avec lymphocytes sanguins binucléés.