Development of telemetry system in the common marmoset--cardiovascular effects of astemizole and nicardipine.
The purpose of this study was to evaluate a telemetry system for examining the cardiovascular system in the conscious common marmoset. Parameters obtained were blood pressure, heart rate, respiratory rate, ECG, body temperature and locomotor activity, and these were continuously recorded on a data recorder via the telemetry system and then processed by a computerized system. Diurnal rhythms of blood pressure, heart rate, body temperature and locomotor activity were observed in this system. We studied the effects of astemizole (antihistamine) and nicardipine (Ca2+ channel blocker) on cardiovascular parameters. Astemizole at 30 mg/kg (p.o.) and at 1 to 3 mg/kg (i.v.), prolonged QT interval and induced ventricular extrasystole. Torsades de pointes occurred in one of three cases at 3 mg/kg (i.v.) and 30 mg/kg (p.o.), while it did not affect the blood pressure, respiratory rate and body temperature. Nicardipine at 30 mg/kg (p.o.) caused sustained hypotension and tachycardia. These results demonstrate the usefulness of the telemetry system using the common marmoset for evaluating the cardiovascular effects of drugs under physiological conditions.
Horii
Ikuo
I
Nippon Roche Research Center, 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
Kito
Go
G
Hamada
Taiji
T
Jikuzono
Tatsuya
T
Kobayashi
Kazuko
K
Hashimoto
Keitaro
K
D000818:Animals; D018926:Anti-Allergic Agents / Q000633:toxicity*; D016589:Astemizole / Q000633:toxicity*; D002121:Calcium Channel Blockers / Q000633:toxicity*; D002144:Callithrix; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D002940:Circadian Rhythm; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects / Q000662:veterinary; D008297:Male; D009529:Nicardipine / Q000633:toxicity*; D013686:Telemetry / Q000379:methods / Q000662:veterinary*
D018926:Anti-Allergic Agents; D002121:Calcium Channel Blockers; D016589:Astemizole; D009529:Nicardipine