title: Polypoidal choroidal vasculopathy with large vascular network.
abstract: OBJECTIVE
  To report characteristics of polypoidal choroidal vasculopathy (PCV) of large vascular networks that expand across the retinal vascular arcade.
  
  
  METHODS
  Among 60 consecutive eyes diagnosed as having PCV by fluorescein and indocyanine green (ICG) angiography, 12 eyes (9 patients) showed large lesions. The clinical and angiographic features of these 12 eyes were studied retrospectively.
  
  
  RESULTS
  Cases of large PCV typically showed dilated network vessels, which spread radially, and multiple polypoidal dilations at the end of the network vessels. Most of the polypoidal dilations formed clusters resembling bunches of grapes and caused large serous and/or hemorrhagic pigment epithelial detachments (PEDs). Among the 12 eyes, 5 showed rapid expansion of the lesions and became large PCVs within 3-24 months. In these eyes, ICG angiography revealed mesh-like choroidal vessels beneath the retinal pigment epithelium.
  
  
  CONCLUSIONS
  PCV with a large vascular network that expands across the vascular arcade is not uncommon. Some of these cases seems to have characteristics of choroidal neovascularization rather than choroidal vasculopathy. It is not easy to distinguish such cases from exudative age-related macular degeneration even though they showed typical findings of PCV on ICG angiography.
authors.affiliation: Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tateiwa
authors.forename: Sachiko
authors.initials: S
authors.lastname: Kuroiwa
authors.forename: Satoko
authors.initials: S
authors.lastname: Gaun
authors.forename: Jun
authors.initials: J
authors.lastname: Arai
authors.forename: Nagahisa
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000098:blood supply*; D015862:Choroid Diseases / Q000175:diagnosis*; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D010857:Pigment Epithelium of Eye / Q000473:pathology; D012163:Retinal Detachment / Q000175:diagnosis
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green