[Construction and study of antigenic characteristics of recombinant salmonella strain producing TBI protein].
A recombinant strain producing TBI protein (artificial protein containing HIV-1 B and T cell epitopes) was constructed on the base of attenuated Salmonella typhimurium SL7207 strain and BALB/c mice were immunized with this strain in a dose of 10(9) live cells orally or rectally. A single immunization with the recombinant salmonella strain induced humoral and cellular immune response to HIV-1; hence, this strain is a promising candidate for vaccine against HIV.
Karpenko
L I
LI
Ignat'ev
G M
GM
Agafonov
A P
AP
Poryvaeva
V A
VA
Lebedev
L P
LP
Veremeĭko
T A
TA
Nekrasova
N A
NA
Klimov
N A
NA
Kozlov
A P
AP
Il'ichev
A A
AA
D016915:AIDS Vaccines / Q000008:administration & dosage / Q000096:biosynthesis / Q000276:immunology*; D000284:Administration, Oral; D000285:Administration, Rectal; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D005813:Genes, Synthetic; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control; D015497:HIV-1 / Q000276:immunology*; D007111:Immunity, Cellular; D007124:Immunoenzyme Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics / Q000276:immunology*; D011994:Recombinant Proteins / Q000096:biosynthesis; D011995:Recombination, Genetic; D012486:Salmonella typhimurium / Q000235:genetics / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000096:biosynthesis / Q000276:immunology
D016915:AIDS Vaccines; D000914:Antibodies, Viral; D011506:Proteins; D011994:Recombinant Proteins; C085784:TBI protein, recombinant; D014614:Vaccines, Synthetic
Konstruirovanie i issledovanie antigennykh svoĭstv rekombinantnogo shtamma sal'monelly, produtsiruiushchego belok TBI.