title: Polymorphism in the mitochondrial cytochrome B gene in Koreans. An additional marker for individual identification.
abstract: Sequencing the mitochondrial control region is very useful for individual identification when conventional DNA typing using autosomal STRs is unavailable. However, low discriminatory power is a problem and another polymorphic locus within the mitochondrial genome is necessary. The cytochrome B (MTCYB) gene, which has undergone several changes during evolution, may be a good candidate for this purpose. Here the sequencing data of the MTCYB gene of 98 unrelated Koreans is presented. A total of 30 polymorphic sites were found which were distributed evenly along the gene. All were nucleotide substitutions and no insertions/deletions were noted. A total of 22 different MTCYB lineages were revealed. Out of 22 different control region lineages with 79 samples which shared the same D-loop sequence with some others within a lineage, 10 lineages with 37 samples could be sub-grouped according to different MTCYB sequences. Some issues concerning the MTCYB gene polymorphism are discussed.
authors.affiliation: Department of Forensic Medicine, Seoul National University College of Medicine, Korea. sdlee@snu.ac.kr
authors.forename: Soong Deok
authors.initials: SD
authors.lastname: Lee
authors.forename: Yoon Seong
authors.initials: YS
authors.lastname: Lee
authors.forename: Jung Bin
authors.initials: JB
authors.lastname: Lee
mesh_terms: D003573:Cytochrome b Group / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000097:blood / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D066298:In Vitro Techniques; D007723:Korea; D011110:Polymorphism, Genetic
chemical_list: D003573:Cytochrome b Group; D004272:DNA, Mitochondrial; D005819:Genetic Markers