Prothrombin G20210A mutation is not associated with recurrent miscarriages.
OBJECTIVE
To assess the association between prothrombin G20210A mutation and recurrent miscarriages.


METHODS
A literature review was performed in Medline identifying articles from 1966 to December 2000. Articles meeting inclusion criteria were systematically reviewed and included in a meta-analysis.


RESULTS
Six trials, all case-controlled, were identified. These trials included 323 women with recurrent pregnancy loss. The odds ratio (OR) for heterozygous prothrombin mutation was 1.9 (95% confidence interval (CI) 0.98-4.14), and for homozygous prothrombin mutation was 3.76 (95% CI 0.75-18.77). The OR for prothrombin mutation and primary recurrent abortion was 2.19 (95% CI 0.61-7.89) and for prothrombin mutation and secondary recurrent abortion was 1.29 (95% CI 0.2-8.36).


CONCLUSIONS
There is no evidence to support an association of prothrombin G20210A mutation with recurrent miscarriages.
Ghee
Chua Boon
CB
Department of Obstetrics and Gynaecology, Monash University, Victoria, Australia.
Burrows
Robert F
RF
D000026:Abortion, Habitual / Q000453:epidemiology / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D016017:Odds Ratio; D017354:Point Mutation; D011247:Pregnancy; D011516:Prothrombin / Q000235:genetics*; D012008:Recurrence; D018570:Risk Assessment; D014739:Victoria / Q000453:epidemiology
D011516:Prothrombin