Physio-mitotic theory and a new concept of embryological differentiation.
According to the physio-mitotic theory described previously by the authors (10,11), general mitosis consists of two different types: essential duplication and converted maturation. In general embryological differentiation, progression for the most fundamental blastocysts of the three germ layers to the immature stem cells comprising functional organic tissues is dependent on the essential duplication mitosis. This mitosis replicates stem cells while gradually initiating latent cellularities whereas the converted maturation process merely amplifies these latent cellularlities by maturing the basic cells in differentiated functional end cells with a pre-determined life span. The differentiation from the three-germ layer to embryologically organized tissues is dependent on duplication mitosis while being regulated by interactions with maturation mitosis. Thus, the complicated embryonic differentiation must be established in each type of organic tissue. During the process, these two types of mitosiseach play an antagonistic role in the embryological development of the other. This is another application of the physio-mitotic theory.
Hirata
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Y
Hirata Hospital, Kochi, Japan.
Hirata
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S
D000818:Animals; D002454:Cell Differentiation; D005314:Embryonic and Fetal Development / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000196:embryology; D008938:Mitosis; D008954:Models, Biological