title: Calcium channel mutations and migraine.
abstract: An increasing number of mutations in the CACNA1A gene have been identified, which are associated with a broad clinical spectrum, including familial hemiplegic migraine. Transfection studies and mouse model analyses are currently being undertaken to study the correlation between CACNA1A mutations and disease.
authors.affiliation: Department of Neurology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands.
authors.forename: Esther E
authors.initials: EE
authors.lastname: Kors
authors.forename: Arn M J M
authors.initials: AM
authors.lastname: van den Maagdenberg
authors.forename: Jaap J
authors.initials: JJ
authors.lastname: Plomp
authors.forename: Rune R
authors.initials: RR
authors.lastname: Frants
authors.forename: Michel D
authors.initials: MD
authors.lastname: Ferrari
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000235:genetics*; D015220:Calcium Channels / Q000235:genetics* / Q000378:metabolism; D020864:Calcium Channels, N-Type; D020865:Calcium Channels, P-Type; D020907:Calcium Channels, Q-Type; D004195:Disease Models, Animal; D004827:Epilepsy / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D051379:Mice; D008881:Migraine Disorders / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D009154:Mutation / Q000235:genetics*; D010641:Phenotype; D009435:Synaptic Transmission / Q000235:genetics
chemical_list: D015220:Calcium Channels; D020864:Calcium Channels, N-Type; D020865:Calcium Channels, P-Type; D020907:Calcium Channels, Q-Type; C105656:CACNA1A protein, human