[Sterility of males determined by functional features of the mouse spermatozoa bearing t-complex].
The mechanisms underlying normal spermatogenesis and its pathology expressed as male sterility determined by t-complex located on chromosome 17 in mice are considered in this review. t-Complex is a very convenient model with diverse markers of expression of the genes involved in development of the functional features of the spermatozoa bearing t-complex. These features include defects of mobility, capacitation, and acrosome reactions, which determine full or partial male sterility. It has been proposed that the defects of capacitation are also inherent in humans and affect male fertility. This homology is confirmed by the presence of the male gene Tcp11 in humans and demonstration of the fact that the protein TCP11 plays a leading role in modulation of the capacitation of murine spermatozoa. Hence it follows that the defects of human genes leading to incomplete binding of the fertilization promoting peptide could play a certain role in a decreased male fertility. All this is essential not only for deeper understanding of the biology of spermatozoa, but also for development of new therapeutic methods of finding and treating the semen pathology.
Safronova
L D
LD
Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 117071 Russia.
Kudriavtsev
I V
IV
Kudriavtsev
P I
PI
D020101:Acrosome Reaction; D000818:Animals; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008565:Membrane Proteins; D051379:Mice; D008869:Microtubule-Associated Proteins; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D010766:Phosphorylation; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000235:genetics / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases; D056427:t-Complex Genome Region
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; C533399:TCP11 protein, human; C533400:Tcp11 protein, mouse; D013973:Thyrotropin-Releasing Hormone; C059697:pyroglutamyl-glutamyl-proline amide; C116196:PPP1R11 protein, human; D044767:Ubiquitin-Protein Ligases; D011761:Pyrrolidonecarboxylic Acid
Steril'nost' samtsov, obuslovlennaia funktsional'nymi osobennostiami spermatozoidov mysheĭ, nesushchikh t-kompleks.