title: Dissolution tests for self-setting calcium phosphate cement-containing nifedipine.
abstract: Nifedipine-containing calcium phosphate cement (CPC) was prepared, and nifedipine (NF) release from this preparation was evaluated by the shaking method (SK), Japanese Pharmacopoeia XIV (JPXIV) paddle method (PD), and JPXIV flow-through cell method (FT). The release of NF from the CPC preparation continued for 7 d or longer by all these methods. This suggests that the release of NF can be controlled by preparing NF-containing CPC. The release pattern of NF from CPC in these tests was found to follow the Higuchi equation. However, the Higuchi constant differed among the three dissolution tests, probably because the apparent tortuosity of capillary system (tau) varied.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Nihon University, Chiba, Japan.
authors.forename: Toyofumi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kifumi
authors.initials: K
authors.lastname: Arai
authors.forename: Hiroko
authors.initials: H
authors.lastname: Goto
authors.forename: Manabu
authors.initials: M
authors.lastname: Hanano
authors.forename: Jun
authors.initials: J
authors.lastname: Watanabe
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tomono
mesh_terms: D002121:Calcium Channel Blockers / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D009543:Nifedipine / Q000737:chemistry*
chemical_list: D002121:Calcium Channel Blockers; D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; D009543:Nifedipine; C485829:calcium phosphate, dibasic, anhydrous