[Chymase in the system proteinase-proteinase inhibitor in pathogenesis of hypertension].
Investigated in the study was activity of proteinases, nontripsin-like proteinases (NTLP), a1-inhibitor of proteinases (a1-PI), and a2-macroglobulin (a2-MG) in the blood serum of workers of the Kharkov tile plant and those of the Institute of Therapy of the AMS of Ukraine, who had been exposed to stress factors, and during the early stages of hypertensive disease (HD). The activity of proteinases, NTLP appeared to be decreased in the group of HD patients. In both groups there was a decrease in the level of a1-PI and a rise of the activity of chimase, a2-MG. The authors have come to the conclusion about prevailing of nervous, immunological stimuli in the above examinees, specificity of the part chimase has in formation and progression of HD, and important role that a2-MG plays in the activity of chimase.
Samokhina
L M
LM
Gol'drin
E N
EN
Ermakovich
I I
II
D000328:Adult; D053818:Chymases; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000378:metabolism*; D008297:Male; D012697:Serine Endopeptidases / Q000097:blood*; D015842:Serine Proteinase Inhibitors / Q000097:blood*; D013315:Stress, Psychological / Q000150:complications; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D015842:Serine Proteinase Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D012697:Serine Endopeptidases; D053818:Chymases
Khimaza v sisteme proteinaza-ingibitor proteinaz v patogeneze gipertonicheskoĭ bolezni.