On computational control of flow in airblast atomisers for pulmonary drug delivery.
Among different approaches to successful pharmacotherapy the pulmonary drug delivery (PDD) mode plays an increasingly important role. In this paper PDD systems based on air-blast atomisation have been analysed mathematically. In order to allow the bioengineer to estimate the degree of effectiveness of a specific system prototype and to lay the basic principles for design, a conservation-law-based mathematical model is discussed. Key control parameters that allow improvement in the efficiency of the system have been identified and main characteristics of the system have been analysed numerically as functions of these parameters.
Melnik
R V N
RV
University of Southern Denmark, Mads Clausen Institute, Grundtvigs Alle 150, Sonderborg DK-6400, Denmark. rmelnick@mci.sdu.dk
Jenkins
David R
DR
D000335:Aerosol Propellants; D000465:Algorithms; D003198:Computer Simulation; D016503:Drug Delivery Systems; D004867:Equipment Design; D008168:Lung / Q000378:metabolism*; D008838:Microcomputers; D008962:Models, Theoretical; D009330:Nebulizers and Vaporizers
D000335:Aerosol Propellants