title: In vitro effects of some steroidal hormones on the replication of avian pneumovirus.
abstract: The effects of testosterone, oestradiol, progesterone and cortisone on the in vitro replication of avian pneumovirus in tracheal organ cultures (TOC) were investigated. Samples of cell-associated and cell-free virus from TOC, grown in medium containing these hormones, were taken at selected intervals. Progesterone and cortisone caused a slight increase in cell-associated virus. Testosterone and oestradiol caused a slight delay and decrease in virus replication when compared with the controls. All groups shared the same time interval to reach peak cell-free virus titre, 96 h post inoculation. In comparison with the controls, only a small drop (0.25-0.50 log10) in the peak of virus titre was observed in the hormone treated groups.
authors.affiliation: Department of Microbiology and Parasitology, College of Veterinary Medicine and Animal Resources, King Faisal University, Al Ahsa, Saudi Arabia.
authors.forename: A I
authors.initials: AI
authors.lastname: Al-Afaleq
authors.forename: R C
authors.initials: RC
authors.lastname: Jones
authors.forename: A M
authors.initials: AM
authors.lastname: Homeida
authors.forename: C E
authors.initials: CE
authors.lastname: Savage
mesh_terms: D000818:Animals; D003348:Cortisone / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D018111:Pneumovirus / Q000187:drug effects* / Q000502:physiology; D011374:Progesterone / Q000494:pharmacology; D013256:Steroids / Q000494:pharmacology*; D013739:Testosterone / Q000494:pharmacology; D014132:Trachea / Q000382:microbiology; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D013256:Steroids; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D003348:Cortisone