title: Estimating the number of Cubans infected sexually by human immunodeficiency virus using contact tracing data.
abstract: BACKGROUND
  To estimate the yearly number of people in Cuba who are living with human immunodeficiency virus (HIV) and were infected through sexual contact but who have not developed acquired immunodeficiency syndrome (AIDS). Estimation was made directly from the yearly HIV seroprevalence data of the Cuban Partner Notification Programme from 1991 to 2000.
  
  
  METHODS
  The generalized removal model for open populations is utilized for the estimation. The total number of known HIV-infected Cubans at each sampling time is used in the prior to provide more reasonable approximations.
  
  
  RESULTS
  We estimated a yearly survival rate of 93%. The median estimates for the number of all living asymptomatic HIV-positive Cubans, infected by sexual contact, tripled from 714 in 1991 to 2170 in 2000. The number of unknown HIV-positive Cubans infected sexually is estimated to range from 174 in 1991 to 401 in 2000.
  
  
  CONCLUSIONS
  A consistent increase in the number of sexually infected HIV-positive individuals in Cuba from 1991 to 2000 is evident from the estimates. From 1996 onwards more sexually active homosexual/bisexual contacts were traced and consequently more sexually-infected HIV-positives were detected. A consequence of increased detection is the levelling off and subsequent decrease in the number of unknown HIV-positives during this time period. The estimation procedure is useful in estimating prevalent population sizes of epidemiological and public health interest.
authors.affiliation: Department of Applied Mathematics, National Chung-Hsing University, Taichung, Taiwan. yhhsieh@dragon.nchu.edu.tw
authors.forename: Ying-Hen
authors.initials: YH
authors.lastname: Hsieh
authors.forename: Hector
authors.initials: H
authors.lastname: de Arazoza
authors.forename: Shen-Ming
authors.initials: SM
authors.lastname: Lee
authors.forename: Cathy W S
authors.initials: CW
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D001499:Bayes Theorem; D016358:Contact Tracing; D003462:Cuba / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D015995:Prevalence