Intravenous to oral conversion of fluoroquinolones: knowledge versus clinical practice patterns.
OBJECTIVE
To assess the knowledge of prescribers regarding intravenous to oral conversions of fluoroquinolones, the frequency and time until conversion, and to compare prescriber knowledge with the data collected concerning the reasons stated for continuation of intravenous fluoroquinolones.


METHODS
Prospective chart review and questionnaire.


METHODS
Large teaching hospital in Paris, France.


METHODS
Fifty-one males and females.


METHODS
Data were collected on in-patients receiving intravenous fluoroquinolone for at least three days and hospitalized in one of six in-patient units. Patients receiving intravenous fluoroquinolone for less than three days were excluded. A questionnaire to assess the awareness of a potential conversion was distributed to those practitioners who had patients reviewed during the data-collection phase.


RESULTS
The questionnaire revealed the ten most common reasons for continuing intravenous administration for more than three days. However, the physicians agreed that most patients should be converted as soon as possible. Practice patterns differed, with only 17 of 51 patients actually converted to oral therapy.


CONCLUSIONS
In theory, the clinicians were aware of when to perform the conversion. However, in practice, the frequency of conversion was lower than optimum. Changes in clinical practice are needed to decrease the costs of intravenous therapy, without jeopardizing quality of care.
Conort
Ornella
O
Department of Pharmacy, Cochin Hospital, Paris, France.
Gabardi
Steven
S
Didier
Marie-Pauline
MP
Hazebroucq
Georges
G
Cariou
Alain
A
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000191:economics / Q000627:therapeutic use; D005260:Female; D024841:Fluoroquinolones; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010820:Physicians / Q000191:economics / Q000706:statistics & numerical data; D010818:Practice Patterns, Physicians' / Q000191:economics / Q000706:statistics & numerical data; D011446:Prospective Studies; D012189:Retrospective Studies; D011795:Surveys and Questionnaires
D000890:Anti-Infective Agents; D024841:Fluoroquinolones