MUC1 and sialoglycan expression associated with cytotoxic T lymphocyte infiltration in eyelid malignant tumors.
OBJECTIVE
To elucidate the relation between infiltrating cytotoxic T lymphocytes and the expression of MUC1 and sialoglycans in malignant eyelid tumors.


METHODS
The distribution of MUC1, Maackia amurensis lectin-II (MAL-II)-recognized sialoglycan, and CD8-positive T lymphocytes was examined histochemically in 14 patients with malignant eyelid tumors: three squamous cell carcinomas, six sebaceous gland carcinomas, and five basal cell carcinomas. The density of CD8-positive cells was examined and correlated with MUC1 and sialoglycan expression.


RESULTS
MUC1 was identified in squamous cell carcinoma and sebaceous gland carcinoma, but not in basal cell carcinoma. CD8-positive cells were more densely distributed in those squamous cell and sebaceous gland carcinoma cases that were more intense in MUC1 expression and weaker in MAL-II binding. Tumors with a strong expression of both MUC1 and MAL-II-bound sialoglycans showed few CD8-positive cells.


CONCLUSIONS
MUC1 with few sialoglycans is likely to induce an intense infiltration of CD8-positive cytotoxic T lymphocytes in eyelid cancers.
Uehara
Fumiyuki
F
Department of Ophthalmology, Kagoshima University Faculty of Medicine, Kagoshima-shi, Japan.
Ohba
Norio
N
D018266:Adenocarcinoma, Sebaceous / Q000378:metabolism / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D002280:Basal Cell Carcinoma / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D005142:Eyelid Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018655:Lymphocyte Count; D016246:Lymphocytes, Tumor-Infiltrating / Q000378:metabolism* / Q000473:pathology; D008297:Male; D012795:Sialoglycoproteins / Q000378:metabolism*; D013602:T-Lymphocytes, Cytotoxic / Q000378:metabolism* / Q000473:pathology
D012795:Sialoglycoproteins