title: Effects of antioxidants on kidney disease.
abstract: Kidney mesangial cells (MCs) and vascular smooth muscle cells (VSMCs) are closely related in terms of origin, microscopic anatomy, histochemistry, and contractility. This relationship suggests a similarity between kidney glomerular sclerosis and atherosclerosis. Vitamin E appears beneficial in the prevention and treatment of coronary disease and also inhibits the proliferation of VSMCs in vitro. We used vitamin E and probucol to treat glomerular sclerosis and MC-proliferative glomerulonephritis (GN) in two animal models of glomerular disease. Using rats, a remnant kidney model accelerated with hyperlipidemia was employed to reflect progressive glomerular sclerosis leading to chronic renal failure, and an anti-thymocyte serum treatment was used to model acute MC-proliferative GN. Supplemental dietary antioxidants suppress MC proliferation and glomerular sclerosis in models of glomerular disease in rats. These results suggest that treatment with antioxidants may be a promising intervention to prevent progression of kidney disease.
authors.affiliation: Department of Internal Medicine (III), Wakayama Medical College, 811-1 Kimiidera, Wakayama 641-0012, Japan. mmune@wakayama-med.ac.jp
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Mune
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Otani
authors.forename: Susumu
authors.initials: S
authors.lastname: Yukawa
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002791:Cholesterol, Dietary / Q000009:adverse effects; D019587:Dietary Supplements; D004195:Disease Models, Animal; D015432:Glomerulonephritis, Membranoproliferative / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D007672:Kidney Cortex / Q000378:metabolism; D008264:Macrophages / Q000166:cytology; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D018800:Thy-1 Antigens / Q000276:immunology; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D002791:Cholesterol, Dietary; D018800:Thy-1 Antigens; D014810:Vitamin E