title: Power of exclusion revisited: probability of excluding relatives of the true father from paternity.
abstract: In parentage testing using DNA markers, the formulae for calculating the probability of exclusion generally overstate the power of a test battery by considering its ability to exclude a random man. It is known that in many cases, in particular immigration applications, the false father is more likely to be a relative, e.g. brother, of the true father than an unrelated man. This work presents formulae that take this consideration into account. A practical example using Hong Kong data is provided to illustrate the effect of the modification. Also discussed is how the expected efficacy of a test battery will be affected when possible mutations and null alleles or genetic inconsistencies are taken into consideration.
authors.affiliation: Department of Statistics and Actuarial Science, The University of Hong Kong, China. wingfung@hku.hk
authors.forename: Wing K
authors.initials: WK
authors.lastname: Fung
authors.forename: Yuk-ka
authors.initials: YK
authors.lastname: Chung
authors.forename: Dart-man
authors.initials: DM
authors.lastname: Wong
mesh_terms: D016172:DNA Fingerprinting / Q000379:methods*; D005190:Family; D005260:Female; D005554:Forensic Medicine; D005819:Genetic Markers; D006723:Hong Kong; D006801:Humans; D008297:Male; D010334:Paternity; D016133:Polymerase Chain Reaction; D011336:Probability; D020080:Tandem Repeat Sequences
chemical_list: D005819:Genetic Markers