title: Recurrent thrombosis of prosthetic mitral valve in idiopathic hypereosinophilic syndrome.
abstract: A 41-year old man, with idiopathic hypereosinophilic syndrome, had severe mitral regurgitation. He had two subsequent mechanical mitral valve thromboses in the setting of rising eosinophilia. A Carpentier-Edwards bioprosthesis was used for the third valve replacement. Some features of myeloproliferative disease, including chromosome 10 abnormality, were identified. A normal eosinophil count and disappearance of the chromosomal abnormality were obtained with interferon, hydroxyurea and prednisone therapy. At 30 months postoperatively, the patient had a normal lifestyle.
authors.affiliation: Department of Cardiovascular Surgery, Gabriel Montpied University Hospital, Clermont-Ferrand, France.
authors.forename: Ko
authors.initials: K
authors.lastname: Watanabe
authors.forename: Olivier
authors.initials: O
authors.lastname: Tournilhac
authors.forename: Lionel F
authors.initials: LF
authors.lastname: Camilleri
mesh_terms: D000328:Adult; D001705:Bioprosthesis; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000601:surgery*; D008297:Male; D008943:Mitral Valve / Q000473:pathology* / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000150:complications* / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology; D012008:Recurrence; D013927:Thrombosis / Q000209:etiology*