title: Epistasis and hybrid sterility in Saccharomyces.
abstract: Hybrid sterility is thought to be due to deleterious epistatic interactions between genes from different species. Here we demonstrate that dominant genic incompatibility does not contribute to sterility in hybrids between Saccharomyces cerevisiae and five closely related species. Sterile diploids were made fertile by genome doubling to produce hybrid tetraploids. Based on these and previous results, we conclude that neither genic incompatibility nor classical chromosomal speciation models apply.
authors.affiliation: The Galton Laboratory, Department of Biology, University College London, Gower Street, UK. ucbtdgr@ucl.ac.uk
authors.forename: Duncan
authors.initials: D
authors.lastname: Greig
authors.forename: Rhona H
authors.initials: RH
authors.lastname: Borts
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Louis
authors.forename: Michael
authors.initials: M
authors.lastname: Travisano
mesh_terms: D003433:Crosses, Genetic; D004843:Epistasis, Genetic; D005799:Genes, Dominant / Q000235:genetics; D005800:Genes, Fungal / Q000235:genetics / Q000502:physiology; D006824:Hybridization, Genetic; D008957:Models, Genetic; D011003:Ploidies; D012098:Reproduction; D012440:Saccharomyces / Q000145:classification / Q000235:genetics* / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology; D013045:Species Specificity