Advanced glycation end products (AGE) and their receptor (RAGE) in the brain of patients with Creutzfeldt-Jakob disease with prion plaques.
The objective of this study was to assess the pathological role of advanced glycation end products (AGE) and the receptor for AGE (RAGE) in Creutzfeldt-Jakob disease (CJD). We immunohistochemically investigated the occipital lobe of three patients with CJD containing with prion protein (PrP) plaques using anti-AGE and RAGE antibodies. Many PrP-positive plaques were observed in these patients, and the PrP-positive prion plaques also showed immunoreactivity for the anti-AGE antibody. Furthermore, many astrocytes contained-PrP positive granules, and the same astrocytes also contained many AGE- and RAGE-immunopositive granules. The staining pattern of these granules showed good concordance with that of PrP. These findings suggest that there may be a RAGE-mediated PrP degradation pathway in CJD as is the case for beta-amyloid protein in Alzheimer's disease.
Sasaki
Nobuyuki
N
Department of Neuropsychiatry, School of Medicine, Sapporo Medical University, S1W16, Chuo-ku, Sapporo 060-8543, Japan. nsasaki@sapmed.ac.jp
Takeuchi
Masayoshi
M
Chowei
Hiroshi
H
Kikuchi
Seiji
S
Hayashi
Yorihide
Y
Nakano
Norihito
N
Ikeda
Hiroshi
H
Yamagishi
Sho-ichi
S
Kitamoto
Tetsuyuki
T
Saito
Toshikazu
T
Makita
Zenji
Z
D001253:Astrocytes / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism* / Q000473:pathology*; D003594:Cytoplasmic Granules / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D009778:Occipital Lobe / Q000378:metabolism / Q000473:pathology; D011328:Prions / Q000378:metabolism*; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism*; D013194:Staining and Labeling
D017127:Glycation End Products, Advanced; D011328:Prions; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic