[Interaction of RNA with phospholipid membranes].
RNAs binding with liposomes under near physiological conditions were obtained by molecular selection. Structural analysis showed that the RNAs could form complexes owing to complementary sequences located in loops. Oligomerization of the RNAs selected was experimentally confirmed. The results and published data testified that formation of high-molecular-weight complexes is a major mechanism increasing the RNA affinity for phospholipid membranes. The role of RNA-membrane interactions in early evolution is discussed in terms of the RNA world hypothesis.
Vlasov
A
A
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, USA. avlassov@somagenics.com
Yarus
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M
D001483:Base Sequence; D008081:Liposomes; D008567:Membranes, Artificial; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009690:Nucleic Acid Conformation; D010743:Phospholipids / Q000737:chemistry* / Q000378:metabolism; D012313:RNA / Q000737:chemistry* / Q000378:metabolism
D008081:Liposomes; D008567:Membranes, Artificial; D010743:Phospholipids; D012313:RNA
Vzaimodeĭstvie RNK s fosfolipidnymi membranami.