Short-term dynamics of circulating T cell receptor V beta repertoire in relapsing-remitting MS.
To understand the short-term dynamics of the circulating T cell receptor V beta (TCRBV) repertoire in relapsing-remitting multiple sclerosis (MS), we monitored the TCRBV profiles of untreated MS patients and healthy controls. Expansions of TCRBV genes in MS patients were significantly more frequent than in controls (P<0.001), were predominantly oligoclonal (80%) and were significantly correlated with immune responses to myelin basic protein (MBP) (P<0.02) and with inflammatory disease activity detected by magnetic resonance imaging (MRI) (P<0.05). Autoreactive T cell responses against myelin antigens may be implicated in perturbations of TCR repertoire in untreated MS patients, detectable even in the absence of clinically evident manifestations.
Muraro
P A
PA
Neurological Clinic, Department of Oncology and Neuroscience, Nuovo Ospedale Clinicizzato, G.D. Annunzio University, Via dei Vestini, 66013 Chieti, Italy. pmuraro@unich.it
Bonanni
L
L
Mazzanti
B
B
Pantalone
A
A
Traggiai
E
E
Massacesi
L
L
Vergelli
M
M
Gambi
D
D
D000328:Adult; D005260:Female; D015870:Gene Expression / Q000276:immunology; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics* / Q000276:immunology; D007136:Immunoglobulins; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology* / Q000473:pathology; D004676:Myelin Basic Protein / Q000276:immunology; D043025:Oligoclonal Bands; D018807:Polymorphism, Single-Stranded Conformational; D012333:RNA, Messenger / Q000032:analysis; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D007135:Immunoglobulin Variable Region; D007136:Immunoglobulins; D004676:Myelin Basic Protein; D043025:Oligoclonal Bands; D012333:RNA, Messenger; D016693:Receptors, Antigen, T-Cell, alpha-beta