title: Clinical characteristics of prostate cancer in elderly Japanese patients 80 years of age or older.
abstract: OBJECTIVE
  Prostate adenocarcinoma is predominantly a disease of elderly men. This study retrospectively examined prostate adenocarcinoma in Japanese patients 80 years of age or older to determine the natural history and prognosis of this malignancy in the elderly population.
  
  
  METHODS
  The medical records of 593 patients were reviewed, with respect to age, histologic grade, clinical and pathological stage, treatment modality and clinical outcome. A variety of possible clinical factors were compared between patient groups > or = 80 and < 80 years old.
  
  
  RESULTS
  No significant difference in clinical stage, tumor grade, and performance status (PS) was found between two age groups of patients with prostate cancer. A significant stage migration between pre-PSA era and PSA era was found only in the group < 80 years old. In the series of stage D2 cancer patients, while there was no significant difference in cause-specific and progression-free survival rates between the two groups, the younger group < 80 years old had a better marker response at 3 months from the start of endocrine therapy compared with the older group (P = 0.0048, chi2 analysis).
  
  
  CONCLUSIONS
  These data suggest that patients > or = 80 years with prostate cancer present with similar histologic grade and disease stage as younger patients, although the younger group with stage D2 had a better marker response to endocrine therapy.
authors.affiliation: Department of Urology, Graduate School of Medicine, Chiba University, Japan.
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Koichiro
authors.initials: K
authors.lastname: Akakura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ueda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mikami
authors.forename: Toyofusa
authors.initials: T
authors.lastname: Tobe
authors.forename: Akira
authors.initials: A
authors.lastname: Komiya
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Igarashi
authors.forename: Haruo
authors.initials: H
authors.lastname: Ito
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000453:epidemiology / Q000401:mortality; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000401:mortality; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D017430:Prostate-Specific Antigen