title: Serological evidence of acute infection with the Chlamydia-like microorganism Simkania negevensis (Z) in acute exacerbation of chronic obstructive pulmonary disease.
abstract: The aims of this study were twofold: (i) to test for possible associations between serological evidence of acute Simkania negevensis (Sn) infection and acute exacerbation of chronic obstructive pulmonary disease and (ii) to examine the prevalence of past infections with Sn in patients with chronic obstructive pulmonary disease. In 120 patients (63%) there was serological evidence of past infection with Sn, which was not significantly different from the rate in a control population. In five hospitalizations serological evidence existed of acute infection with Sn around the time of the exacerbation of chronic obstructive pulmonary disease. In four of these cases, there was serological evidence of acute infection with at least one other respiratory pathogen. It is concluded that Sn can be associated serologically with exacerbation of chronic obstructive pulmonary disease, in most cases together with other respiratory pathogens. The implications of these findings should be investigated further.
authors.affiliation: Pulmonary Unit and Division of Internal Medicine, Soroka Medical Center of Kupat Holim, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Lieberma@bgumail.bgu.ac.il
authors.forename: D
authors.initials: D
authors.lastname: Lieberman
authors.forename: B
authors.initials: B
authors.lastname: Dvoskin
authors.forename: D V
authors.initials: DV
authors.lastname: Lieberman
authors.forename: S
authors.initials: S
authors.lastname: Kahane
authors.forename: M G
authors.initials: MG
authors.lastname: Friedman
mesh_terms: D000208:Acute Disease; D000368:Aged; D002694:Chlamydiaceae Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology*; D002695:Chlamydiales / Q000276:immunology / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000276:immunology / Q000382:microbiology*; D016036:Seroepidemiologic Studies; D012698:Serologic Tests
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G