title: Fringe phenotypes in autism: a review of clinical, biochemical and cognitive studies.
abstract: Progress in identifying the genetic vulnerability factors in autism requires correct identification of the inherited phenotype(s). This can be achieved not only by the accurate description of the affected subject but also by the identification of vulnerability traits in non-affected relatives of autistic probands. This review will focus on this last strategy and principally on clinical, biochemical and cognitive traits.
authors.affiliation: Consultation autisme, service de psychopathologie de l'enfant et de l'adolescent, hôpital Robert Debré, assistance publique-hôpitaux de Paris, 75019, Paris, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Goussé
authors.forename: Marie Hélène
authors.initials: MH
authors.lastname: Plumet
authors.forename: Nadia
authors.initials: N
authors.lastname: Chabane
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Mouren-Siméoni
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ferradian
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
mesh_terms: D001321:Autistic Disorder / Q000150:complications* / Q000235:genetics* / Q000378:metabolism; D003072:Cognition Disorders / Q000209:etiology*; D003147:Communication Disorders / Q000209:etiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D010641:Phenotype; D012701:Serotonin / Q000378:metabolism; D012920:Social Behavior Disorders / Q000209:etiology; D019956:Stereotypic Movement Disorder / Q000209:etiology
chemical_list: D012701:Serotonin