Obesity and diabetes mellitus--how are they linked?
There is a large body of evidence which indicates that elevated plasma levels of FFA are a major cause of insulin resistance in skeletal muscle and liver. Normalizing plasma FFA levels is, therefore, proposed as a novel approach to reduce insulin resistance, the risk of Type 2 diabetes mellitus and atherosclerotic vascular disease.
Boden
Guenther
G
D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D009765:Obesity / Q000150:complications* / Q000378:metabolism*
D005230:Fatty Acids, Nonesterified; D007328:Insulin