Further studies on the anti-oxidative effect of putrescine in sodium nitrite-treated rats.
In recent years, dietary polyamines, including putrescine, have attracted considerable interest because of the suggestion that their presence in human diet many have some anti-oxidative properties. Therefore, studies were carried out to elucidate the anti-oxidative effect(s) of oral putrescine supplementation in rats pretreated per os with either sodium nitrite or normal saline (control). Results suggest that putrescine is an effective anti-oxidant agent, which mitigates nitrite-induced lipid peroxidation in rat liver and small intestinal mucosa.
Grudziński
Ireneusz P
IP
Department of Applied Physiology, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland.
Frankiewicz-Jóźko
Anna
A
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D011700:Putrescine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012977:Sodium Nitrite; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000975:Antioxidants; D002273:Carcinogens; D017392:Thiobarbituric Acid Reactive Substances; D012977:Sodium Nitrite; D011700:Putrescine