The effects of oral glutamine on cisplatin-induced genotoxicity in Wistar rat bone marrow cells.
Several studies have suggested that dietary supplementation with antioxidants can influence the response to chemotherapy as well as the development of adverse side effects that result from treatment with antineoplastic agents. The emphasis of the present study was to investigate whether the administration of a single dose of oral glutamine had any protective effect against cisplatin-induced clastogenicity. Cisplatin was administered to Wistar rats either alone or after treatment with glutamine. The rats were treated with glutamine (300 mg/kg b.w.) by gavage 24h before the administration of cisplatin (5mg/kg b.w., i.p.) and then sacrificed 24h after treatment with cisplatin. Glutamine significantly reduced (by about 48%) the clastogenicity of cisplatin in rat bone marrow cells. The antioxidant action of glutamine presumably modulates the clastogenic action of cisplatin.
Mora
Luciana de Oliveira
Lde O
Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. Café s/n. 14040-903, Ribeirão Preto, São Paulo, Brazil.
Antunes
Lusânia Maria Greggi
LM
Francescato
Heloísa Della Coletta
HD
Bianchi
Maria Lourdes Pires
ML
D000284:Administration, Oral; D000818:Animals; D016587:Antimutagenic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000633:toxicity; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000187:drug effects*; D002869:Chromosome Aberrations; D002945:Cisplatin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D005973:Glutamine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009153:Mutagens / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
D016587:Antimutagenic Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D009153:Mutagens; D005973:Glutamine; D002945:Cisplatin