Novel plasmid-encoded class C beta-lactamase (MOX-2) in Klebsiella pneumoniae from Greece.
Klebsiella pneumoniae KOL, a clinical strain resistant to various beta-lactams, was isolated from the stools of a patient from Greece. This strain harbored a new pI 9.1 plasmid-mediated AmpC beta-lactamase with unusually high levels of hydrolytic activity for cefoxitin and cefotetan that we named MOX-2. Sequencing of bla(MOX-2) revealed 93.2, 92.9, 92.7, and 73.1% identities with the deduced amino acid sequences of CMY-8, MOX-1, CMY-1, and the AmpC beta-lactamase of Aeromonas sobria, respectively.
Raskine
Laurent
L
Service de Bacteriologie-Virologie, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, 75475 Paris Cedex 10, France. laurent.raskine@lrb.ap-hop-paris.fr
Borrel
Isabelle
I
Barnaud
Guilène
G
Boyer
Sophie
S
Hanau-Berçot
Béatrice
B
Gravisse
Jérome
J
Labia
Roger
R
Arlet
Guillaume
G
Sanson-Le-Pors
Marie-José
MJ
D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D007711:Klebsiella pneumoniae / Q000235:genetics*; D008969:Molecular Sequence Data; D010957:Plasmids; D001618:beta-Lactamases / Q000737:chemistry / Q000235:genetics*
D001426:Bacterial Proteins; C048795:AmpC beta-lactamases; D001618:beta-Lactamases