Hepatic injury induced by interleukin-18 administration: importance of preceding priming effect.
The priming effects of obstructive jaundice by bile duct ligation on interleukin (IL)-18-induced hepatic injury are investigated. The production of IL-12 and tumor necrosis factor-alpha increased 3 days after bile duct ligation. Subsequent IL-18 injection to rats with obstructive jaundice caused by BDL resulted in prominent interferon-gamma production and hepatic injury. These results suggest that IL-18 with IL-12 and/or tumor necrosis factor-alpha have synergistic effects on the induction of hepatic injury via interferon-gamma production on this model.
Shibata
Muneyuki
M
Department of Surgery II, Kumamoto University Medical School, Kumamoto-City, Japan.
Hirota
Masahiko
M
Ogawa
Michio
M
D000818:Animals; D001652:Bile Ducts / Q000503:physiopathology; D002779:Cholestasis / Q000378:metabolism* / Q000503:physiopathology; D016207:Cytokines / Q000097:blood* / Q000378:metabolism; D004195:Disease Models, Animal; D018664:Interleukin-12 / Q000009:adverse effects / Q000494:pharmacology; D020382:Interleukin-18 / Q000009:adverse effects* / Q000494:pharmacology*; D008026:Ligation; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D011336:Probability; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012680:Sensitivity and Specificity
D016207:Cytokines; D020382:Interleukin-18; D018664:Interleukin-12