title: Involvement of granulocyte-macrophage colony-stimulating factor (GM-CSF) in pregnancy-enhanced sleep.
abstract: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a crucial cytokine for establishing pregnancy. It has been demonstrated previously in rats that sleep increases during early pregnancy and that centrally administered GM-CSF promotes both rapid eye movement (REM) and non-REM sleep. Therefore, whether GM-CSF is involved in pregnancy-enhanced sleep was investigated using the anti-GM-CSF antibody. Female rats received an intracerebroventricular infusion of either anti-GM-CSF or control IgG (10 microg each) for four nights from the first day of pregnancy (PD1-PD4). Although sleep amounts on PD1 were not affected, anti-GM-CSF decreased non-REM and REM sleep significantly during PD2-PD4 compared with the control baseline of the IgG group. The results demonstrated that anti-GM-CSF treatment suppresses pregnancy-enhanced sleep, suggesting that GM-CSF contributes to sleep regulation during pregnancy.
authors.affiliation: Department of Biocybernetics, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan. mkimura.bcy@tmd.ac.jp
authors.forename: Mayumi
authors.initials: M
authors.lastname: Kimura
authors.forename: Shojiro
authors.initials: S
authors.lastname: Inoué
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D012894:Sleep Stages / Q000502:physiology*
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor