Large-scale sources of neural stem cells.
Large-scale sources of neural stem cells are crucial for both basic research and novel approaches toward treating neurological disorders. Three sources that produce neural cells closely resembling their normal counterparts are now available: oncogene immortalized stem cells, neurospheres, and embryonic stem cell (ES)-derived neural cells. Cells including multiple subtypes of CNS and PNS neurons, as well as oligodendrocytes, Schwann cells, and astrocytes, are modeled by these large-scale sources. Although most cell lines were originally from rodents, their human counterparts are being discovered and characterized.
Gottlieb
David I
DI
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, USA. gottlied@pcg.wustl.edu
D000818:Animals; D016380:Brain Tissue Transplantation / Q000379:methods*; D018929:Cell Culture Techniques / Q000379:methods* / Q000639:trends; D002454:Cell Differentiation / Q000502:physiology; D002460:Cell Line / Q000145:classification / Q000166:cytology / Q000637:transplantation*; D006801:Humans; D009457:Neuroglia / Q000166:cytology / Q000637:transplantation*; D009474:Neurons / Q000166:cytology / Q000637:transplantation*; D018874:Spheroids, Cellular / Q000166:cytology / Q000637:transplantation; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology; D014407:Tumor Cells, Cultured / Q000145:classification / Q000166:cytology / Q000637:transplantation