title: The effect of 5 years of annual treatment with ivermectin (Mectizan) on the prevalence and morbidity of onchocerciasis in the village of Gami in the Central African Republic.
abstract: To assess the impact of 5 years of annual community treatment with ivermectin (Mectizan) on the prevalence of onchocerciasis and onchocerciasis-associated morbidity, data collected, before and after such treatment, in the village of Gami, in a hyper-endemic area of the Central African Republic, were analysed. Skin snips from all the villagers treated in 1990 and/or 1995 were used to assess the prevalence and intensity of infection with Onchocerca volvulus. Ocular and dermatological morbidity was assessed by ophthalmological and clinical examinations of the same subjects. Following the five annual treatments, there was a reduction in the prevalence of infection and a dramatic decrease in the microfilarial load of the community. The prevalences of pruritus, onchocercal nodules and impaired vision were all significantly reduced. The results emphasise the long-term benefits of the mass-treatment programmes, particularly for children aged <10 years.
authors.affiliation: Task Force for Child Survival, Mectizan Donation Program, 750 Commerce Drive, Decatur, GA 30030, USA. mmk4@cdc.gov
authors.forename: M H
authors.initials: MH
authors.lastname: Kennedy
authors.forename: I
authors.initials: I
authors.lastname: Bertocchi
authors.forename: A D
authors.initials: AD
authors.lastname: Hopkins
authors.forename: S E
authors.initials: SE
authors.lastname: Meredith
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000977:Antiparasitic Agents; D002488:Central African Republic / Q000453:epidemiology; D002648:Child; D003430:Cross-Sectional Studies; D019353:Endemic Diseases; D005260:Female; D005369:Filaricides / Q000627:therapeutic use*; D006801:Humans; D007559:Ivermectin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009855:Onchocerciasis / Q000188:drug therapy* / Q000453:epidemiology*; D015827:Onchocerciasis, Ocular / Q000188:drug therapy / Q000453:epidemiology; D015995:Prevalence; D011537:Pruritus / Q000453:epidemiology / Q000469:parasitology; D017678:Sex Distribution; D012876:Skin Diseases, Parasitic / Q000453:epidemiology
chemical_list: D000977:Antiparasitic Agents; D005369:Filaricides; D007559:Ivermectin