title: [Idiopathic granulomatous hypophysitis. Morphological and immunohistochemical study of a case].
abstract: Inflammatory diseases of the pituitary gland constitute a group of interest because of their scarce frequency, because the disorder presents with symptoms of hypopituitarism and expanding sellar mass and because of their therapeutics implications. We present one case of idiopathic granulomatous hypophysitis, in a 55-years-old patient with daily headaches, panhypopituitarism and a sellar mass lesion. Granulomatous hypophysitis is characterized by granulomas with epithelioid histiocytes and multinucleated giant cells but also shows lymphocyte collections. With respect to immunohistochemistry our results show histiocytes (CD68+) and an heterogeneous inflammatory infiltrate (CD45RO+ y CD20+). We analyze the differential diagnosis with another granulomatous processes, infectious or not infectious, and with the histiocytosis. We examine the possible relation with the lymphocytic hypophysitis.
authors.affiliation: Departamento de Patología, Hospital Clínico Universitario, Facultad de Medicina, Universidad de Valencia.
authors.forename: C
authors.initials: C
authors.lastname: Illueca
authors.forename: M
authors.initials: M
authors.lastname: Cerdá-Nicolás
authors.forename: P
authors.initials: P
authors.lastname: Roldan
authors.forename: F
authors.initials: F
authors.lastname: Talamantes
authors.forename: J
authors.initials: J
authors.lastname: Ascaso
authors.forename: A
authors.initials: A
authors.lastname: Llombart-Bosch
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015415:Biomarkers; D003937:Diagnosis, Differential; D005260:Female; D006099:Granuloma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D006261:Headache / Q000209:etiology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology; D016130:Immunophenotyping; D007249:Inflammation; D008214:Lymphocytes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis; D010900:Pituitary Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D010902:Pituitary Gland / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D009419:Nerve Tissue Proteins; D011241:Prednisone
vernacular_title: Hipofisitis granulomatosa idiopática. Estudio morfológico e inmunohistoquímico de una observación.