Hypocretin-1 (orexin-A) concentrations in cerebrospinal fluid are low in patients with Guillain-Barré syndrome.
It is reported that cerebrospinal fluid (CSF) hypocretin-1 (orexin-A) concentrations in patients with narcolepsy are significantly low. Human narcolepsy is also known to be closely associated with a specific human histocompatibility leukocyte antigen (HLA), suggesting that autoimmunity is involved in the pathophysiology of the disease. Thus, it is important to know whether hypocretin changes are found in definite neuroimmunological diseases such as multiple sclerosis and Guillain-Barré syndrome (GBS). The results of the present study indicate that some patients with GBS have lower levels of CSF hypocretin-1.
Kanbayashi
Takashi
T
Department of Neuropsychiatry, Akita University School of Medicine, Japan. takashik@psy.med.akita-u.ac.jp
Ishiguro
Hideaki
H
Aizawa
Rika
R
Saito
Yasushi
Y
Ogawa
Yuriko
Y
Abe
Masahito
M
Hirota
Kouichi
K
Nishino
Seiji
S
Shimizu
Tetsuo
T
D000704:Analysis of Variance; D002352:Carrier Proteins / Q000134:cerebrospinal fluid* / Q000276:immunology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid* / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D009479:Neuropeptides / Q000134:cerebrospinal fluid* / Q000276:immunology; D000068797:Orexins
D002352:Carrier Proteins; C000596229:HCRT protein, human; D006680:HLA Antigens; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins