title: In vitro antimycobacterial and antilegionella activity of licochalcone A from Chinese licorice roots.
abstract: Licochalcone A, extracted and purified from Chinese licorice roots, showed in vitro inhibitory effect on human pathogenic Mycobacteria species and Legionella species. M. tuberculosis, M. bovis and BCG were inhibited by < 20 mg/l licochalcone A, whereas all non- M. tuberculosis complex species were resistant to > 20 mg/l Legionella pneumophila (serogroups 1 - 7) and L. bozemanii, L. dumoffii, L. feelei, L. longbeacheae and L. wadsworthii were inhibited by licochalcone A 1 - 4 mg/l, whereas L. gormanii and L. micdadei were inhibited by licochalcone A 500 - 1000 mg/l. These data indicate that licochalcone A might be of interest as a new class of antibacterial drug in the treatment of severe lung-infections.
authors.affiliation: Department of Clinical Microbiology, Hvidovre Hospital, Copenhagen, Denmark. alice.friis-moeller@hh.hosp.dk
authors.forename: Alice
authors.initials: A
authors.lastname: Friis-Møller
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.forename: Kurt
authors.initials: K
authors.lastname: Fuursted
authors.forename: Søren Brøgger
authors.initials: SB
authors.lastname: Christensen
authors.forename: Arsalan
authors.initials: A
authors.lastname: Kharazmi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047188:Chalcones; D004365:Drugs, Chinese Herbal; D006035:Glycyrrhiza; D007875:Legionella / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009159:Mycobacteriaceae / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D012293:Rifampin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D047188:Chalcones; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D002599:Chalcone; C070840:licochalcone A; D012293:Rifampin