title: Phosphorylation of Helicobacter pylori CagA in patients with gastric ulcer and gastritis.
abstract: The effects of Helicobacter pylori infection are strongly associated with chronic gastritis, gastric and duodenal ulcer, gastric cancer, and MALT lymphoma. The microorganism has been classified as a type I carcinogen by the World Health Organization. Varying clinical results from H. pylori infection are believed due, in part, to differences in virulence among species. The cag pathogenicity island is a complex of virulent genes and a coding region for the type IV phosphorylated secretion system. Through this system, many virulent gene products or proteins are phosphorylated into the host cells. This study demonstrated the positive CagA-phosphorylation effect of H. pylori in patients with chronic gastritis and benign gastric ulcer and revealed significantly different rates of CagA phosphorylation between these two diseases (P<.05).
authors.affiliation: Department of Internal Medicine, China Medical College Hospital, Taichung, Taiwan.
authors.forename: Ken-Sheng
authors.initials: KS
authors.lastname: Cheng
authors.forename: Min-Chi
authors.initials: MC
authors.lastname: Lu
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Tang
authors.forename: Fu-Tsan
authors.initials: FT
authors.lastname: Chou
mesh_terms: D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D003470:Culture Media; D005260:Female; D005756:Gastritis / Q000382:microbiology*; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D013276:Stomach Ulcer / Q000382:microbiology*
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D003470:Culture Media; C080866:cagA protein, Helicobacter pylori