title: Hypocretin-1 (orexin-A) concentrations in cerebrospinal fluid are low in patients with Guillain-Barré syndrome.
abstract: It is reported that cerebrospinal fluid (CSF) hypocretin-1 (orexin-A) concentrations in patients with narcolepsy are significantly low. Human narcolepsy is also known to be closely associated with a specific human histocompatibility leukocyte antigen (HLA), suggesting that autoimmunity is involved in the pathophysiology of the disease. Thus, it is important to know whether hypocretin changes are found in definite neuroimmunological diseases such as multiple sclerosis and Guillain-Barré syndrome (GBS). The results of the present study indicate that some patients with GBS have lower levels of CSF hypocretin-1.
authors.affiliation: Department of Neuropsychiatry, Akita University School of Medicine, Japan. takashik@psy.med.akita-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanbayashi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ishiguro
authors.forename: Rika
authors.initials: R
authors.lastname: Aizawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Saito
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Masahito
authors.initials: M
authors.lastname: Abe
authors.forename: Kouichi
authors.initials: K
authors.lastname: Hirota
authors.forename: Seiji
authors.initials: S
authors.lastname: Nishino
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000704:Analysis of Variance; D002352:Carrier Proteins / Q000134:cerebrospinal fluid* / Q000276:immunology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid* / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D009479:Neuropeptides / Q000134:cerebrospinal fluid* / Q000276:immunology; D000068797:Orexins
chemical_list: D002352:Carrier Proteins; C000596229:HCRT protein, human; D006680:HLA Antigens; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins