title: Chronic evaluation of the Cleveland Clinic CorAide left ventricular assist system in calves.
abstract: The Cleveland Clinic CorAide left ventricular assist system is based on a third-generation, implantable, centrifugal pump in which a rotating assembly is suspended fully. To evaluate chronic in vivo system performance and biocompatibility, the CorAide blood pump was implanted in 18 calves for either 1 month or 3 months. Hemodynamics were stable in all calves with a mean pump flow of 5.9 +/- 1.2 L/min and a mean systemic arterial pressure of 98 +/- 5 mm Hg. There were no incidences of bleeding, organ dysfunction, or mechanical failure in any of the 18 calves. Hemolysis occurred in only 1 calf due to outflow graft stenosis. Thrombus inside the pump, seen in 4 of the first 6 cases, was totally eliminated by a final redesign in the remaining cases, including the last 6 implants conducted without anticoagulation therapy. The CorAide blood pump demonstrated good biocompatibility and reliable, effective system performance.
authors.affiliation: Department of Biomedical Engineering and Biological Resources Unit, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Ochiai
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Doi
authors.forename: Alex L
authors.initials: AL
authors.lastname: Massiello
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Medvedev
authors.forename: David J
authors.initials: DJ
authors.lastname: Horvath
authors.forename: Renee L
authors.initials: RL
authors.lastname: Gerhart
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Chen
authors.forename: Alexandra Y
authors.initials: AY
authors.lastname: Krogulecki
authors.forename: Masami
authors.initials: M
authors.lastname: Takagaki
authors.forename: Michael W
authors.initials: MW
authors.lastname: Howard
authors.forename: Michael W
authors.initials: MW
authors.lastname: Kopcak
authors.forename: Leonard A R
authors.initials: LA
authors.lastname: Golding
mesh_terms: D000818:Animals; D002417:Cattle; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology; D011474:Prosthesis Design; D015203:Reproducibility of Results; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology / Q000628:therapy*