Extracorporeal therapies for acute intoxications.
Intoxications frequently perturb acid-base and electrolyte status, intravascular volume, and renal function. In selected cases, extracorporeal techniques effectively restore homeostasis and augment intoxicant removal. The use of 4-methylpyrazole, an inhibitor of alcohol dehydrogenase, is a new and effective treatment for patients exposed to toxic alcohols. In this section, practical approaches to commonly encountered intoxicants and the use of extracorporeal techniques are critically reviewed.
Borkan
Steven C
SC
Department of Medicine, Boston University, Boston Medical Center, Renal Section, Boston, MA, USA. sborkan@bu.edu
D000438:Alcohols / Q000506:poisoning; D006801:Humans; D018020:Lithium Compounds / Q000506:poisoning; D011041:Poisoning / Q000175:diagnosis / Q000628:therapy*; D012459:Salicylates / Q000506:poisoning; D016060:Sorption Detoxification / Q000379:methods*; D019966:Substance-Related Disorders / Q000150:complications / Q000628:therapy; D013806:Theophylline / Q000506:poisoning
D000438:Alcohols; D018020:Lithium Compounds; D012459:Salicylates; D013806:Theophylline