Antifungal Sordarins. Part 4: synthesis and structure--activity relationships of 3',4'-fused alkyl-tetrahydrofuran derivatives.
A series of Sordarin derivatives bearing alkyl substituted tetrahydrofuran rings fused to C3'-C4' bond of the sugar moiety have been prepared and their antifungal properties evaluated. Most of them show remarkable antifungal activity against Candida spp and Cryptococcus neoformans.
Bueno
José M
JM
GlaxoSmithkline, Research Department, Parque Tecnológico de Madrid, Severo Ochoa, 2.28760 Tres Cantos, Madrid, Spain.
Chicharro
Jesús
J
Fiandor
José M
JM
Gómez de las Heras
Federico
F
Huss
Sophie
S
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015725:Fluconazole / Q000494:pharmacology; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007192:Indenes; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D005663:Furans; C412607:GM193663; D007192:Indenes; C003329:sordarin; C018674:tetrahydrofuran; D015725:Fluconazole