title: Prostatic carcinoma with emphasis on Gleason's Grading: an institution based experience.
abstract: OBJECTIVE
  To grade prostatic carcinomas according to the Gleason's Grading System and see whether the frequency of incidental carcinoma is significant.
  
  
  METHODS
  Retrospective study of all consecutive cases of prostatic adenocarcinoma diagnosed at Aga Khan University Hospital (AKUH) between January 1st, 1996 and December 31st, 1999.
  
  
  METHODS
  The histopathology section of AKUH, Karachi.
  
  
  METHODS
  Prostatic adenocarcinomas comprised 14.2% of all prostate specimens. There were 3 types of specimens i.e. transurethral resection, suprapubic prostatectomies and core biopsies. The mean age was 72.1 years; 68.1% patients were 65 years or older. The majority of the tumours were moderately differentiated (Gleason's scores 5,6 or 7). Grading was not possible in most core biopsies. The frequency of incidental carcinoma was 31.4%.
  
  
  CONCLUSIONS
  Majority of tumours were moderate to poorly differentiated, indicating that prostatic adenocarcinoma is an aggressive disease. The frequency of incidental carcinoma was also high emphasizing need for more aggressive prostatic evaluation in the vulnerable age group.
authors.affiliation: Department of Pathology, Aga Khan University Hospital, Karachi.
authors.forename: Z
authors.initials: Z
authors.lastname: Ahmed
authors.forename: S
authors.initials: S
authors.lastname: Muzaffar
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D017430:Prostate-Specific Antigen