The human cytomegalovirus US8 glycoprotein binds to major histocompatibility complex class I products.
Human cytomegalovirus US8 is a type I membrane protein that partially colocalizes with cellular endosomal and lysosomal proteins. Although US8 does not have discernible effects on the processing and cell surface distribution of major histocompatibility complex (MHC) class I products, we have demonstrated that US8 binds to MHC class I heavy chains in the endoplasmic reticulum.
Tirabassi
Rebecca S
RS
Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
Ploegh
Hidde L
HL
D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005347:Fibroblasts; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000378:metabolism*
D015395:Histocompatibility Antigens Class I; D008562:Membrane Glycoproteins; C456061:US8 protein, Human herpesvirus 5; D014764:Viral Proteins