title: Exogenous testosterone, aggression, and mood in eugonadal and hypogonadal men.
abstract: To investigate (1) the effects of exogenous testosterone (T) on self- and partner-reported aggression and mood and (2) the role of trait impulsivity in the T-aggression relationship. Thirty eugonadal men with partners were randomized into two treatment groups to receive: (1) 200 mg im T enanthate weekly for 8 weeks or (2) 200 mg im sodium chloride weekly for 8 weeks. Eight hypogonadal men received 200 mg im T enanthate biweekly for 8 weeks. All groups completed a battery of behavior measures at baseline (Week 0) and at Weeks 4 and 8. Cognitive and motor impulsivity were the only predictors of self-reported total aggression (over and above age and T levels) at Weeks 0, 4, and 8. No significant changes in aggression or mood levels were found in the eugonadal-treated group. Significant reductions in negative mood (tension, anger, and fatigue) followed by an increase in vigor were found in response to T treatment in the hypogonadal group. These results demonstrate that inability to control one's behavior when such control is required by a particular situation (impulsivity) was found to significantly predict levels of aggression over and above age and T level. These data do not support the hypothesis that supraphysiological levels of T (within this range) lead to an increase in self- and partner-reported aggression or mood disturbances. Instead, for the first time, this study has identified the high level of negative affect experienced by hypogonadal patients. These findings have implications for T replacement therapy and male contraception.
authors.affiliation: Department of Endocrinology, Manchester Royal Infirmary, Manchester M13 9WL, UK. daryloc@psychology.leeds.ac.uk
authors.forename: Daryl B
authors.initials: DB
authors.lastname: O'Connor
authors.forename: John
authors.initials: J
authors.lastname: Archer
authors.forename: W Morton
authors.initials: WM
authors.lastname: Hair
authors.forename: Frederick C W
authors.initials: FC
authors.lastname: Wu
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects*; D000374:Aggression / Q000187:drug effects*; D000786:Anger / Q000187:drug effects; D020249:Hormone Replacement Therapy; D006791:Hostility; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy / Q000523:psychology*; D007175:Impulsive Behavior / Q000523:psychology; D007398:Interpersonal Relations; D008297:Male; D010556:Personality Tests; D012649:Self Concept; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D013739:Testosterone