Giardia intestinalis glucosamine 6-phosphate isomerase: the key enzyme to encystment appears to be controlled by ubiquitin attachment.
The cyst wall of the parasitic protozoan, Giardia intestinalis, is composed of a polymer of N-acetylgalactosamine, the precursor of which is synthesized by an inducible enzyme pathway. The first enzyme in this pathway, glucosamine 6-phosphate isomerase, is transcriptionally regulated. During encystment and in mature cysts this isomerase appears to be modified by ubiquitin attachment. Thus, it might be targeted for destruction by an ubiquitin-mediated pathway, suggesting that glucosamine 6-phosphate isomerase expression is tightly regulated.
Lopez
Alex B
AB
Department of Biological, Geological and Environmental Sciences, Cleveland State University, Ohio 44115, USA.
Hossain
Mohammed T
MT
van Keulen
Harry
H
D019747:Aldose-Ketose Isomerases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation; D003001:Cloning, Molecular; D016054:DNA, Protozoan; D004790:Enzyme Induction; D005786:Gene Expression Regulation; D017125:Genes, Protozoan; D016829:Giardia lamblia / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism*
D016054:DNA, Protozoan; D011994:Recombinant Proteins; D025801:Ubiquitin; C020582:glucosamine-6-phosphate isomerase; D019747:Aldose-Ketose Isomerases