The Achilles' heel of HIV.
A virus uses surface molecules to enter the cell and subsequently multiplies using the cell's machinery. Vaccination induces the whole immunological capability to get rid of the virus. However, viruses found several ways to escape from immunological elimination. Blocking viral entry is another way to prevent viral spread. Here, we describe a method to block HIV entry by inhibiting the association of the two viral proteins that are involved in viral entry.
Torensma
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Nijmegen Center for Molecular LifeSciences, Nijmegen, The Netherlands.
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D001665:Binding Sites; D006678:HIV / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D015699:HIV Envelope Protein gp120 / Q000502:physiology; D015700:HIV Envelope Protein gp41 / Q000502:physiology; D015658:HIV Infections / Q000517:prevention & control* / Q000821:virology; D006801:Humans; D008954:Models, Biological; D015728:Receptors, HIV / Q000037:antagonists & inhibitors / Q000502:physiology
D015699:HIV Envelope Protein gp120; D015700:HIV Envelope Protein gp41; D015728:Receptors, HIV