title: LEDGF, a survival factor, activates stress-related genes.
abstract: LEDGF is a survival factor and it enhances survival of various cell types against stress. LEDGF is also a transcriptional activator and it binds to promoter elements of heat shock and stress-related genes to activate expression of these genes. The elevated levels of the stress-related family of proteins, such as heat shock proteins, antioxidant proteins, and detoxication enzymes might suppress apoptosis induced by stress. The protective mechanisms against stress in mammalian cells and in yeast are surprisingly similar.
authors.affiliation: Brigham and Women's Hospital, Department of Ophthalmology, Center for Ophthalmic Research, Harvard Medical School, Boston, MA 02115, USA. tshinohara@rics.bwh.harvard.edu
authors.forename: Toshimichi
authors.initials: T
authors.lastname: Shinohara
authors.forename: Dhirendra P
authors.initials: DP
authors.lastname: Singh
authors.forename: Nigar
authors.initials: N
authors.lastname: Fatma
mesh_terms: D000818:Animals; D016923:Cell Death; D002470:Cell Survival / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D010786:Photoreceptor Cells / Q000502:physiology; D011401:Promoter Regions, Genetic; D017434:Protein Structure, Tertiary; D012164:Retinal Diseases / Q000503:physiopathology; D012441:Saccharomyces cerevisiae / Q000502:physiology; D013312:Stress, Physiological / Q000235:genetics* / Q000503:physiopathology; D014158:Transcription, Genetic
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; C119380:lens epithelium-derived growth factor