Distribution of HLA-B alleles in nasopharyngeal carcinoma patients and normal controls in Thailand.
HLA-B frequencies in 54 unrelated nasopharyngeal carcinoma (NPC) patients and 49 healthy random controls in Thailand were investigated by direct DNA sequencing. Similar to previous reports in Chinese NPC patients, HLA-B*4601 was observed at a greater frequency in patients (21/54 (40%)) compared to controls (7/49 (14%). An increase in HLA-B*51012 was also demonstrated. B*51012 was present in 6/54 (11%) NPC patients but was not observed (0%) in controls. B*44032 was associated with a decreased risk. Five out of 54 (9%) NPC patients had B*44032 compared to 14/49 (29%) in the control group.
Pimtanothai
Nattiya
N
Immunology Unit, Department of Microbiology, Georgetown University, Waxhington, DC, USA. Nattiyap@hotmail.com
Charoenwongse
P
P
Mutirangura
A
A
Hurley
C K
CK
D000293:Adolescent; D000368:Aged; D000483:Alleles; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology; D019309:Epstein-Barr Virus Nuclear Antigens / Q000235:genetics / Q000378:metabolism; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics*; D059949:HLA-B51 Antigen; D006239:Haplotypes; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D013785:Thailand
D019309:Epstein-Barr Virus Nuclear Antigens; D015235:HLA-B Antigens; C469674:HLA-B*46:01 antigen; C469675:HLA-B*51:01:02 antigen; D059949:HLA-B51 Antigen; C417029:EBV-encoded nuclear antigen 1