Bacterial superantigen exposure after resolution of influenza virus infection perturbs the virus-specific memory CD8(+)-T-cell repertoire.
Heterologous viral infections have been shown to impact the preexisting memory CD8(+)-T-cell repertoire. Bacterial superantigens are products of common human pathogenic bacteria, including staphylococci and streptococci, that are potent T-cell-stimulatory molecules. In this report, we show that exposure to staphylococcal enterotoxin B, a bacterial superantigen, causes a selective functional deletion of cross-reactive influenza virus-specific CD8(+) memory T cells. This perturbation of the memory repertoire can have a significant impact on viral clearance after secondary challenge.
Huang
Chiu-Chen
CC
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Shah
Sangeeta
S
Nguyen
Phuong
P
Altman
John D
JD
Blackman
Marcia A
MA
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004768:Enterotoxins / Q000276:immunology*; D007156:Immunologic Memory; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism; D018089:Superantigens / Q000276:immunology*; D014758:Viral Core Proteins / Q000276:immunology
D004768:Enterotoxins; D010446:Peptide Fragments; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens; D014758:Viral Core Proteins; C102366:nucleoprotein (366-374), influenza virus; C031818:enterotoxin B, staphylococcal