title: Serum malondialdehyde correlates with therapeutic efficiency of high activity antiretroviral therapies (HAART) in HIV-1 infected children.
abstract: Serum malondialdehyde (MDA) levels are increased in human immunodeficiency virus (HIV)-infected children, as it happens also in infected adult individuals. Introduction of high activity antiretroviral therapy (HAART) has promoted an intense decline in morbidity and mortality of these patients. Here we present data on the effect of HAART on serum MDA of HIV+ children and compare them with levels prior to HAART. MDA levels reflect, as other markers do, the HAART-induced clinical improvement and probably also the pro-oxidant/antioxidant side effects of the different drugs used. The results herein allow the proposal of including serum MDA levels as an additional parameter for the clinical management of HIV+ children.
authors.affiliation: Servicio de Pediatría, Hospital Clínico Universitario, Valencia, Spain.
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: Jareño
authors.forename: Joaquín
authors.initials: J
authors.lastname: Romá
authors.forename: Belén
authors.initials: B
authors.lastname: Romero
authors.forename: Nuria
authors.initials: N
authors.lastname: Marín
authors.forename: María
authors.initials: M
authors.lastname: Muriach
authors.forename: Siv
authors.initials: S
authors.lastname: Johnsen
authors.forename: Francisco
authors.initials: F
authors.lastname: Bosch-Morell
authors.forename: Lena
authors.initials: L
authors.lastname: Marselou
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Romero
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D015415:Biomarkers / Q000097:blood*; D002648:Child; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress
chemical_list: D019380:Anti-HIV Agents; D015415:Biomarkers; D008315:Malondialdehyde