title: [Clinical and pathogenic evaluation of acid-base, gas and electrolyte homeostasis in patient with leptospirosis and acute renal insufficiency].
abstract: With the purpose of further perfecting the pathogenetic therapy, indices for the acid-base status were studied together with those for the electrolyte exchange in the time-related course of the disease in patients with grave leptospiral jaundice presenting with acute renal failure (ARF). Patients with leptospirosis running a grave course and ARF display changes in the acid-base status and gas composition of the blood. Patients presenting with oligoanuric ARF and fatal outcome develop uncompensated metabolic acidosis (11.8%), in case of favourable outcome--metabolic acidosis with compensation by respiratory alkalosis (29.4%). The polyuric ARF stage is characterized by a mixed metabolic and respiratory alkalosis (58.8%). Results of studies made warrant use of indices for the acid-base, gas, and electrolyte balance to assess severity and prognosis of leptospirosis, to determine the stage of ARF, and to develop rational pathogenetic therapies.
authors.forename: L I
authors.initials: LI
authors.lastname: Zhukova
authors.forename: G V
authors.initials: GV
authors.lastname: Mel'nik
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000378:metabolism*; D000328:Adult; D002245:Carbon Dioxide / Q000097:blood*; D004573:Electrolytes / Q000097:blood*; D005260:Female; D006706:Homeostasis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007922:Leptospirosis / Q000150:complications / Q000378:metabolism*; D008297:Male; D010100:Oxygen / Q000097:blood*
chemical_list: D004573:Electrolytes; D002245:Carbon Dioxide; D010100:Oxygen
vernacular_title: Kliniko-patogeneticheskaia otsenka kislotno-osnovnogo, gazovogo i élektrolitnogo gomeostaza u bol'nykh leptospirozom s ostroĭ pochechnoĭ nedostatochnost'iu.