Sphingosylphosphorylcholine-biological functions and mechanisms of action.
Compared to the lysophospholipid mediators, sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), little information is available regarding the molecular mechanisms of action, metabolism and physiological significance of the related sphingosylphosphorylcholine (SPC). S1P and LPA have recently been established as agonists at several G-protein-coupled receptors of the EDG family, S1P additionally serves an intracellular second messenger function. Several cellular effects of SPC can be explained by low-affinity binding to and activation of S1P-EDG receptors. However, certain cellular and subcellular actions of SPC are not shared by S1P, suggesting that SPC, which has been identified in normal blood plasma, ascites and various tissues, is a lipid mediator in its own right. This concept was corroborated by the recent discovery of specific high-affinity G-protein-coupled SPC receptors. In this article, our present knowledge on cellular actions and biological functions of SPC will be reviewed.
Meyer zu Heringdorf
Dagmar
D
Institut für Pharmakologie, Universitätsklinikum Essen, Hufelandstrasse 55, Essen, Germany. meyer.heringdorf@uni-essen.de
Himmel
Herbert M
HM
Jakobs
Karl H
KH
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology; D010767:Phosphorylcholine / Q000031:analogs & derivatives*; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000502:physiology*
D008246:Lysophospholipids; D011956:Receptors, Cell Surface; C005356:sphingosine phosphorylcholine; D010767:Phosphorylcholine; C060506:sphingosine 1-phosphate; D019204:GTP-Binding Proteins; D013110:Sphingosine