title: New factors in the regulation of adipose differentiation and metabolism.
abstract: Obesity and lipoatrophy are major risks for insulin resistance, type 2 diabetes and cardiovascular diseases. The molecular links between adipocyte dysfunction and metabolic disorders were elusive until the discovery that adipose tissue operates as an endocrine organ and releases factors targeting a wide range of organs. This article attempts to review the more recent advances from research on the transcriptional control of adipogenesis and on new adipocyte-secreted proteins that have been proposed as molecular links between adipose tissue and insulin resistance.
authors.affiliation: Institute of Signaling, Developmental Biology and Cancer, Center for Biochemistry, UFR Sciences, Parc Valrose, Nice, France.
authors.forename: Dorte
authors.initials: D
authors.lastname: Holst
authors.forename: Paul A
authors.initials: PA
authors.lastname: Grimaldi
mesh_terms: D052242:Adiponectin; D000273:Adipose Tissue / Q000166:cytology* / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D006729:Hormones, Ectopic / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D020932:Nerve Growth Factor; D009765:Obesity / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D052243:Resistin; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D052242:Adiponectin; D006729:Hormones, Ectopic; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; C499624:RETN protein, human; C486574:RETNLB protein, human; D018160:Receptors, Cytoplasmic and Nuclear; D052243:Resistin; C499623:Retn protein, mouse; C413576:Retnla protein, mouse; D014157:Transcription Factors; D020932:Nerve Growth Factor