Biotechnological production of 2-phenylethanol.
2-Phenylethanol (2-PE) is an important flavour and fragrance compound with a rose-like odour. Most of the world's annual production of several thousand tons is synthesised by chemical means but, due to increasing demand for natural flavours, alternative production methods are being sought. Harnessing the Ehrlich pathway of yeasts by bioconversion of L-phenylalanine to 2-PE could be an option, but in situ product removal is necessary due to product inhibition. This review describes the microbial production of 2-PE, and also summarizes the chemical syntheses and the market situation.
Etschmann
M M W
MM
Dechema e.V., Biochemical Engineering Group, Theodor-Heuss-Allee 25, 60486 Frankfurt am Main, Germany. etschmann@dechema.de
Bluemke
W
W
Sell
D
D
Schrader
J
J
D001419:Bacteria / Q000378:metabolism; D001709:Biotechnology / Q000379:methods*; D002617:Chemical Industry / Q000379:methods; D005285:Fermentation; D005421:Flavoring Agents / Q000378:metabolism*; D005658:Fungi / Q000378:metabolism; D010626:Phenylethyl Alcohol / Q000138:chemical synthesis / Q000378:metabolism*
D005421:Flavoring Agents; D010626:Phenylethyl Alcohol