title: HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans.
abstract: Animals sense many environmental stimuli simultaneously and integrate various sensory signals within the nervous system both to generate proper behavioral responses and also to form relevant memories. HEN-1, a secretory protein with an LDL receptor motif, regulates such processes in Caenorhabditis elegans. The hen-1 mutants show defects in the integration of two sensory signals and in behavioral plasticity by paired stimuli, although their sensation capability seems to be identical to that of the wild-type. The HEN-1 protein is expressed in two pairs of neurons, but expression in other neurons is sufficient for wild-type behavior. In addition, expression of HEN-1 at the adult stage is sufficient. Thus, HEN-1 regulates sensory processing non-cell-autonomously in the mature neuronal circuit.
authors.affiliation: Structural Biology Center, National Institute of Genetics, Mishima, Japan. tishihar@lab.nig.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishihara
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Iino
authors.forename: Akiko
authors.initials: A
authors.lastname: Mohri
authors.forename: Ikue
authors.initials: I
authors.lastname: Mori
authors.forename: Keiko
authors.initials: K
authors.lastname: Gengyo-Ando
authors.forename: Shohei
authors.initials: S
authors.lastname: Mitani
authors.forename: Isao
authors.initials: I
authors.lastname: Katsura
mesh_terms: D020816:Amino Acid Motifs / Q000235:genetics; D000818:Animals; D012634:Bodily Secretions / Q000502:physiology; D017173:Caenorhabditis elegans / Q000166:cytology / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D019143:Evolution, Molecular; D005786:Gene Expression Regulation / Q000502:physiology; D018398:Homeodomain Proteins / Q000235:genetics; D007858:Learning / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D009420:Nervous System / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D009434:Neural Pathways / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D009479:Neuropeptides / Q000172:deficiency / Q000235:genetics; D010641:Phenotype; D010802:Phylogeny; D011973:Receptors, LDL / Q000737:chemistry / Q000235:genetics; D012677:Sensation / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D029742:Caenorhabditis elegans Proteins; C459682:HEN-1 protein, C elegans; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D011973:Receptors, LDL; C108368:TTX-3 protein, C elegans