title: Ganglioside reactive antibodies in the neuropathy associated with celiac disease.
abstract: We tested patients with celiac disease (CD) for the presence of serum anti-ganglioside antibodies. Six of twenty-seven patient sera were reactive against brain gangliosides by an agglutination immunoassay. Neurological examination in all six revealed the presence of distal sensory loss, consistent with the diagnosis of peripheral neuropathy. When tested by ELISA for antibodies to isolated GM1, GM2, GD1a, GD1b, GT1b, and GQ1b gangliosides, all six were positive for IgG antibodies to at least one. The neuropathy of celiac disease may be autoimmune and associated with anti-ganglioside antibodies. The presence of IgG reactivity furthermore implicates a T cell-mediated response to ganglioside antigens.
authors.affiliation: Department of Neurology and Neuroscience, Cornell University, 525 E. 68th St., LC-807, New York, NY 10021, USA. ara2004@med.cornell.edu
authors.forename: Armin
authors.initials: A
authors.lastname: Alaedini
authors.forename: Peter H R
authors.initials: PH
authors.lastname: Green
authors.forename: Howard W
authors.initials: HW
authors.lastname: Sander
authors.forename: Arthur P
authors.initials: AP
authors.lastname: Hays
authors.forename: Eugenia T
authors.initials: ET
authors.lastname: Gamboa
authors.forename: Alessio
authors.initials: A
authors.lastname: Fasano
authors.forename: Michelle
authors.initials: M
authors.lastname: Sonnenberg
authors.forename: Linda D
authors.initials: LD
authors.lastname: Lewis
authors.forename: Norman
authors.initials: N
authors.lastname: Latov
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002446:Celiac Disease / Q000150:complications / Q000276:immunology*; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D005732:Gangliosides; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M