title: [A low-fat and high soybean protein diet for patients with elevated serum PSA level: alteration of QOL and serum PSA level after the dietary intervention].
abstract: Considerable epidemiological evidence has indicated a relationship between diet and prostate cancer. Many studies have shown positive associations between dietary fat and prostate cancer, and inverse associations with soybean intake. To prevent prostate cancer, we have tried dietary intervention for patients showing an elevated prostate specific antigen (PSA) level. A total of 96 patients who did not show any evidence of prostate cancer by transrectal ultrasonography and/or prostate biopsy despite high serum PSA level were placed on a supervised dietary intervention program consisting of a low fat and high soybean protein diet. The primary endpoint was the alteration of quality of life (QOL) and PSA after 3 months of intervention. Response to the questionnaire indicated that 88% of the patients desired to join such a study, and that 90% of the patients continued the dietary control after 3 months of supervision. About 60% patients adhered strictly to the dietary menus, and 90% of the subject planed to continue. Less than 20% of the patients complained of deterioration of dietary QOL. The average serum PSA level decreased from 6.9 ng/ml to 5.6 ng/ml after 3 months, which was statistically significant (p = 0.01). This dietary intervention almost maintains the patient's QOL, decreases the serum PSA level, and indicates the possibility of prevention of prostate cancer by dietary intervention.
authors.affiliation: Hitachi General Hospital.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Tsutsumi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Shiga
authors.forename: Satoru
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishikawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018752:Diet, Fat-Restricted; D004044:Dietary Proteins / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000517:prevention & control; D011788:Quality of Life; D030262:Soybean Proteins / Q000008:administration & dosage*
chemical_list: D004044:Dietary Proteins; D030262:Soybean Proteins; D017430:Prostate-Specific Antigen