title: Lung diseases due to environmental exposures to erionite and asbestos in Turkey.
abstract: Asbestos deposits have been used locally by the rural inhabitants of Central and Southeastern Anatolia for domestic purposes for many years. Mineralogical analysis revealed that tremolite is the most prominent asbestos type found in the region. There is in addition another mineral fiber found particularly in three villages located in the Cappadocian region of Central Anatolia (zeolite villages). This is a non-asbestos mineral, which has been identified as the fibrous zeolite, erionite. This fiber is present in the volcanic tuffs, which are used as building stone. Hence, exposure to erionite fibers is always possible in the houses, annexes, and streets of the villages. It has been demonstrated that both asbestos and erionite cause a variety of benign and malignant chest diseases. Among the diseases, calcified pleural plaques (CPP) are the most frequently seen and may be used as an indicator of mineral fiber exposure. Asbestos and erionite exposure are the main causes of malignant mesotheliomas in Turkey. In zeolite villages malignant mesothelioma is responsible for more than 50% of the total deaths. A recent study showed that simian virus 40 is not a cofactor in the pathogenesis of environmental malignant mesothelioma in Turkey. An additional recent genetic-epidemiological study showed that there are some families, which are genetically predisposed to mesothelioma.
authors.affiliation: Department of Chest Diseases, Hacettepe Medical Faculty, Hacettepe University Hospital, Sihhiye, 06100 Ankara, Turkey. se06-k@tr.net
authors.forename: Salih
authors.initials: S
authors.lastname: Emri
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demir
authors.forename: Meral
authors.initials: M
authors.lastname: Dogan
authors.forename: Hadi
authors.initials: H
authors.lastname: Akay
authors.forename: Bülent
authors.initials: B
authors.lastname: Bozkurt
authors.forename: Michele
authors.initials: M
authors.lastname: Carbone
authors.forename: Izzettin
authors.initials: I
authors.lastname: Baris
mesh_terms: D001194:Asbestos / Q000009:adverse effects*; D002273:Carcinogens / Q000008:administration & dosage*; D004781:Environmental Exposure / Q000009:adverse effects*; D005192:Family Health; D006680:HLA Antigens / Q000378:metabolism; D006801:Humans; D008171:Lung Diseases / Q000453:epidemiology / Q000209:etiology*; D008654:Mesothelioma / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D010995:Pleural Diseases / Q000453:epidemiology / Q000209:etiology; D010997:Pleural Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D015995:Prevalence; D011379:Prognosis; D014421:Turkey / Q000453:epidemiology; D017641:Zeolites / Q000009:adverse effects*
chemical_list: D002273:Carcinogens; D006680:HLA Antigens; C083174:erionite; D017641:Zeolites; D001194:Asbestos