title: Single nucleotide polymorphisms in CAPN10 gene of Chinese people and its correlation with type 2 diabetes mellitus in Han people of northern China.
abstract: OBJECTIVE
  To investigate the distribution of single nucleotide polymorphisms (SNPs) in CAPN10 gene in Chinese population and their relation with type 2 diabetes mellitus in Han people of Northern China.
  
  
  METHODS
  CAPN10 gene was sequenced to detect SNPs in different nationalities of China. Five SNPs were chosen to perform case-control study and haplotype analysis in 156 normal Han people of Northern China and 173 type 2 diabetes. One SNP was also analyzed with transmission-disequilibrium test (TDT) and sib transmission-disequilibrium test (STDT) in 68 type 2 diabetes pedigrees (377 people).
  
  
  RESULTS
  A total of 40 SNPs were identified in length of 8,936 bp, with an average of 1 in every 223 bp. The SNPs in CAPN10 gene did not distribute evenly and the SNPs in Chinese were different from those reported in Mexican American. There was no significantly statistical difference in the allele frequency of the 5 SNPs between case and control, and the haplotype frequencies in the two groups were not significantly different. No positive results was found in TDT and STDT analysis.
  
  
  CONCLUSIONS
  The SNP distribution of CAPN10 gene differs in different nationalities. The studied SNPs in CAPN10 gene may not be the major susceptibility ones of type 2 diabetes mellitus in Han people of Northern China.
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Sun
authors.forename: Kui-Xing
authors.initials: KX
authors.lastname: Zhang
authors.forename: Wei-Nan
authors.initials: WN
authors.lastname: Du
authors.forename: Jin-Xiu
authors.initials: JX
authors.lastname: Shi
authors.forename: Zheng-Wen
authors.initials: ZW
authors.lastname: Jiang
authors.forename: Hao
authors.initials: H
authors.lastname: Sun
authors.forename: Jin
authors.initials: J
authors.lastname: Zuo
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Zhu
authors.initials: Z
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Yao
authors.forename: Bo-Qin
authors.initials: BQ
authors.lastname: Qiang
authors.forename: Fu-De
authors.initials: FD
authors.lastname: Fang
mesh_terms: D002154:Calpain / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology* / Q000235:genetics*; D005006:Ethnicity; D020022:Genetic Predisposition to Disease; D006801:Humans; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
chemical_list: D002154:Calpain; C415197:calpain 10