Late endocrine, metabolic and skeletal sequelae following treatment of childhood cancer.
With an ever increasing adult population of childhood cancer survivors there is a need to focus on the late effects of cancer therapy. It is essential that, after discharge from the paediatric oncologists, the patients are not lost from the health system but are under continued surveillance with access to the appropriate physicians. Endocrine and metabolic consequences may affect a patient's life both soon after cancer treatment and also for many years in the future. In this review we consider the following potential problems: growth hormone deficiency and replacement in adulthood, cardiovascular risk factors, osteopaenia, thyroid and parathyroid dysfunction.
Gleeson
Helena K
HK
Department of Endocrinology, Christie Hospital, Wilmslow Road, Manchester, Withington, M20 4BX, UK.
Darzy
Ken
K
Shalet
Stephen M
SM
D000970:Antineoplastic Agents / Q000009:adverse effects*; D001847:Bone Diseases / Q000209:etiology*; D002318:Cardiovascular Diseases / Q000209:etiology; D002648:Child; D004700:Endocrine System Diseases / Q000209:etiology*; D012739:Gonadal Steroid Hormones / Q000008:administration & dosage; D019382:Human Growth Hormone / Q000172:deficiency; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects*; D013959:Thyroid Diseases / Q000209:etiology
D000970:Antineoplastic Agents; D012739:Gonadal Steroid Hormones; D019382:Human Growth Hormone