title: The effect of dietary intervention through the modification of fatty acids composition and antioxidant vitamin intake on plasma TXB(2) level in Korean postmenopausal women with hypercholesterolemia.
abstract: The purpose of this study was to observe the effects of dietary intervention, through the modification of dietary fatty acids composition and antioxidant vitamins, on plasma thromboxane B(2) (TXB(2)) levels in postmenopausal women with hypercholesterolemia. The subjects were treated for 12 weeks with one of three methods: hormone replacement therapy (HRT group, n=8), dietary intervention (DIET group, n=8), or HRT combined with dietary intervention (HRT +DIET group, n=8). Changes in serum phospholipid fatty acids composition, serum peroxides, and plasma TXB(2) levels were measured at weeks 0, 4 and 12. The P/S ratio increased and the n-6/ n-3 ratio decreased in the DIET and the HRT +DIET group at week 4 (p<0.05). The ratio of C20:5/C20:4 in serum phospholipid increased in the DIET (p<0.05) and the HRT +DIET groups (NS) at week 4. Plasma TXB(2) levels decreased in the DIET (-35%, p<0.05) and the HRT +DIET groups (-18.8%, NS) at week 4. Serum lipid peroxides levels significantly decreased by 10.5% and 15.2% in the DIET group at weeks 4 and 12, and by 10.8% in the HRT +DIET group only at week 12 (p<0.05). Dietary intervention may lower thrombotic risks in Korean postmenopausal women by changing the serum fatty acid composition, serum lipid peroxides levels and plasma thromboxane B(2) levels.
authors.affiliation: Korean Living Science Research Institute, Hanyang University, Seoul, Korea. kaj0417@hanmail.net
authors.forename: Kyungah
authors.initials: K
authors.lastname: Jung
authors.forename: Sangyeon
authors.initials: S
authors.lastname: Kim
authors.forename: Jeongik
authors.initials: J
authors.lastname: Woo
authors.forename: Yookyung
authors.initials: Y
authors.lastname: Chang
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage* / Q000378:metabolism; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage / Q000097:blood; D015914:Estrogen Replacement Therapy; D005227:Fatty Acids / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D015227:Lipid Peroxidation; D008875:Middle Aged; D017698:Postmenopause; D013929:Thromboxane B2 / Q000097:blood*; D014801:Vitamin A / Q000008:administration & dosage / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood
chemical_list: D000975:Antioxidants; D004041:Dietary Fats; D005227:Fatty Acids; D014801:Vitamin A; D014810:Vitamin E; D013929:Thromboxane B2; D001205:Ascorbic Acid