title: A polymorphism in the interleukin-1alpha gene influences the clinical features of migraine.
abstract: OBJECTIVE
  To evaluate whether a particular genotype of the interleukin-1alpha (IL1A) gene affects the clinical features of migraine.
  
  
  BACKGROUND
  Proinflammatory mediators have been reported to play a role in the pathophysiology of migraine. Recent studies suggest that polymorphisms in the interleukin-1 genes influence the age at onset and subsequent course of several chronic inflammatory diseases.
  
  
  METHODS
  In a group of 269 patients with migraine, we tested the association of the -889 C/T biallelic polymorphism of the IL1A gene with several clinical features of the disease.
  
  
  RESULTS
  Patients with migraine carrying the T/T genotype show an age at onset of the disease that is significantly (P <.01) lower than IL1A C/C or C/T carriers. In addition, the same genotype was significantly (P <.05) more frequent in patients with migraine with aura than in patients with migraine without aura.
  
  
  CONCLUSIONS
  The results of our study suggest a role for the IL1A gene in modifying the clinical features of migraine.
authors.affiliation: Neurology III, Headache Center, Department of Neuroscience, University of Torino, Italy.
authors.forename: Innocenzo
authors.initials: I
authors.lastname: Rainero
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Pinessi
authors.forename: Giuliana
authors.initials: G
authors.lastname: Salani
authors.forename: Walter
authors.initials: W
authors.lastname: Valfrè
authors.forename: Chiara
authors.initials: C
authors.lastname: Rivoiro
authors.forename: Lidia
authors.initials: L
authors.lastname: Savi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gentile
authors.forename: Rossana Lo
authors.initials: RL
authors.lastname: Giudice
authors.forename: Luigi M E
authors.initials: LM
authors.lastname: Grimaldi
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D020325:Migraine with Aura / Q000235:genetics*; D020326:Migraine without Aura / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D007375:Interleukin-1