title: Ionone derivatives from Alternanthera sessilis.
abstract: The chloroform extract of the air-dried leaves of Alternanthera sessilis afforded a mixture of diastereomers of a new ionone derivative 1 whose structures were elucidated by extensive 1D and 2D NMR spectroscopy and mass spectrometry. Oxidative cleavage of 1 to aldehyde 3 with manganese dioxide confirmed diastereoisomerism arose from a racemic side chain chiral centre. Antimicrobial tests on the mixture of diastereomers and the derivative indicated that they have low activities against Pseudomonas aeruginosa and Trichophyton mentagrophytes.
authors.affiliation: Chemistry Department, De La Salle University, Manila, Philippines. coscyr.cos.dlsu-manila@mail.dlsu.edu.ph
authors.forename: Consolacion Y
authors.initials: CY
authors.lastname: Ragasa
authors.forename: Noemi
authors.initials: N
authors.lastname: Tremor
authors.forename: John A
authors.initials: JA
authors.lastname: Rideout
mesh_terms: D027703:Amaranthaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D013729:Terpenes