Indium trichloride mediated intramolecular Prins-type cyclization.
[reaction: see text] Intramolecular Prins-type reactions of compounds having both functionalities of homoallyl alcohol and acetal moiety are described. The intramolecular Prins cyclizations were performed using indium trichloride in chloroform or 25% aqueous THF. Both 9-oxabicyclo[3.3.1]nonane and 3,9-dioxabicyclo[3.3.1]nonane compounds were successfully obtained in moderate yields.
Cho
Yong Seo
YS
Biochemicals Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea. ys4049@kist.re.kr
Kim
Hye Yeon
HY
Cha
Joo Hwan
JH
Pae
Ae Nim
AN
Koh
Hun Yeong
HY
Choi
Jung Hoon
JH
Chang
Moon Ho
MH