title: [Ulcero-necrotic and lymphoproliferative naso-paranasal lesions in cocaine abuse].
abstract: In this work are reported two clinical cases of cocaine abusers with destructive lesions of nasal-paranasal cavities. The clinical presentation and the absence of a positive history of drug addiction led to a differential diagnosis between lymphoma, idiopathic median line granuloma and Wegener granulomatosis. Biochemical and serological examinations did not prove conclusive. The diagnosis was finally formulated on the basis of the documented presence of cocaine in the biological fluids. Emphasis is placed in the difficulty of obtaining a reliable case history in this type of patients. Moreover, the Authors point out that it is advisable to test for drugs in the biological fluids prior to undertaking time-consuming diagnostic procedures for pathologies which are extremely rare in the West countries.
authors.affiliation: Divisione di Oncologia Medica, Ospedale Fatebenefratelli e Oftalmico, Milano.
authors.forename: C
authors.initials: C
authors.lastname: Bianchi
authors.forename: R
authors.initials: R
authors.lastname: Rovej
authors.forename: A
authors.initials: A
authors.lastname: Ferrari
authors.forename: F
authors.initials: F
authors.lastname: Bianchi
authors.forename: U
authors.initials: U
authors.lastname: Conti
authors.forename: E
authors.initials: E
authors.lastname: Corgiolu
authors.forename: M
authors.initials: M
authors.lastname: Richichi
authors.forename: A
authors.initials: A
authors.lastname: Scanni
mesh_terms: D000328:Adult; D019970:Cocaine-Related Disorders / Q000150:complications*; D005260:Female; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000209:etiology; D009336:Necrosis; D010254:Paranasal Sinus Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014456:Ulcer / Q000000981:diagnostic imaging / Q000473:pathology*
vernacular_title: Lesioni ulceronecrotiche e linfoproliferative naso-paranasali da abuso di cocaina.