Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5 Delta 32 allele.
Entry of HIV-1 into a cell happens only after viral envelope glycoproteins have bound to CD4 and a chemokine receptor. Generally, macrophage-tropic strains use CCR5, and T cell-line-tropic strains use CXCR4 as coreceptors for virus entry. Dual-tropic viruses can use both CCR5 and CXCR4. About 1% of white people are homozygous for a non-functional CCR5 allele, containing a 32 base pair deletion (CCR5 Delta 32). We studied the persistence of dual-tropic HIV-1 in an individual homozygous for this deletion. Our results suggest that structural features of the HIV-1 envelope linked to CCR5 tropism could confer a selective advantage in vivo.
Gorry
Paul R
PR
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Zhang
Chengsheng
C
Wu
Sam
S
Kunstman
Kevin
K
Trachtenberg
Elizabeth
E
Phair
John
J
Wolinsky
Steven
S
Gabuzda
Dana
D
D000328:Adult; D000483:Alleles; D018791:CD4 Lymphocyte Count; D016827:CD8 Antigens; D006679:HIV Seropositivity / Q000235:genetics / Q000276:immunology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006720:Homozygote; D006801:Humans; D008297:Male; D019713:Receptors, CCR5 / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication
D016827:CD8 Antigens; D019713:Receptors, CCR5