title: Evaluation and development of spinosyns to control ectoparasites on cattle and sheep.
abstract: The spinosyns are a novel family of fermentation-derived natural products that exhibit potent insecticidal activities. Spinosad, a naturally-occurring mixture of spinosyn A and spinosyn D, has successfully established its utility for crop protective applications in the agrochemical field. Potential applications of this unique chemical family of macrolides also have been investigated in the field of animal health. Applications for the control of blowfly strike and lice on sheep have now been commercially developed and registered in Australia and potential applications for the control of ectoparasites on cattle are being studied.
authors.affiliation: Elanco Animal Health Research and Development, 2001 West Main Street, Greenfield, Indiana 46140, USA. kirst_herbert_a@lilly.com
authors.forename: Herbert A
authors.initials: HA
authors.lastname: Kirst
authors.forename: Lawrence C
authors.initials: LC
authors.lastname: Creemer
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Naylor
authors.forename: Paul T
authors.initials: PT
authors.lastname: Pugh
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Snyder
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Winkle
authors.forename: L Barry
authors.initials: LB
authors.lastname: Lowe
authors.forename: James T
authors.initials: JT
authors.lastname: Rothwell
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Sparks
authors.forename: Thomas V
authors.initials: TV
authors.lastname: Worden
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D002417:Cattle; D004341:Drug Evaluation; D004478:Ectoparasitic Infestations / Q000188:drug therapy* / Q000517:prevention & control / Q000662:veterinary; D007313:Insecta / Q000187:drug effects; D018942:Macrolides; D012756:Sheep; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C114883:spinosyn A; C114884:spinosyn D