title: Age-specific uncertainty in particulate deposition for 1 microm AMAD particles using the ICRP 66 lung model.
abstract: The ICRP 66 lung model may be used to determine age-specific dose estimates for members of the public via the inhalation pathway. A significant source of uncertainty in internal dosimetric modeling is due to particulate deposition in regions of the respiratory tract. Uncertainties in estimates of particulate deposition are present because of the inherent variability in the deposition model and its various input parameters. An improved understanding of the uncertainty in particulate deposition will further guide research efforts and improve our ability to quantify internal dose estimates. The ICRP 66 lung deposition model is most sensitive to breathing rate when 1 microm AMAD particles are inhaled by members of the public. Uncertainties in deposition fractions are shown to span an order of magnitude with their distributions varying by age and sex for a particular lung region. Age-specific uncertainties of deposition fraction demonstrate increased estimates of extrathoracic deposition in younger age groups due to the decreased size of the respiratory tract airways. This age-specific trend becomes more pronounced for very young children and infants. The largest fractional deposition occurs in the alveolar and extrathoracic regions, regardless of age and sex.
authors.affiliation: Department of Environmental Health Sciences, University of Michigan, Ann Arbor 48109, USA. harveyr@ne.orst.edu
authors.forename: R P
authors.initials: RP
authors.lastname: Harvey
authors.forename: D M
authors.initials: DM
authors.lastname: Hamby
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000396:Air Pollutants, Radioactive / Q000493:pharmacokinetics*; D001980:Bronchi / Q000033:anatomy & histology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D019570:Inhalation Exposure; D008168:Lung / Q000033:anatomy & histology* / Q000528:radiation effects*; D008297:Male; D008953:Models, Anatomic; D008954:Models, Biological; D009058:Mouth Breathing; D010316:Particle Size; D011835:Radiation Protection; D012119:Respiration; D012126:Respiratory Dead Space; D014132:Trachea / Q000033:anatomy & histology
chemical_list: D000396:Air Pollutants, Radioactive