title: Triterpene saponins from Craniotome furcata.
abstract: Three saponins, craniosaponin A (1) and buddlejasaponins Ia (2) and I (3) were isolated from the n-butanol soluble fraction of Craniotome furcata for the first time. Among them, craniosaponin A (1) was identified to be a new compound. The structure of craniosaponin A was assigned mainly by spectral methods. A preliminary assay in vitro was applied to evaluate their cytotoxicity against several tumor cell-lines.
authors.affiliation: Institute of Materia Medica, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, PR China.
authors.forename: Cheng-Qi
authors.initials: CQ
authors.lastname: Fan
authors.forename: Hai-Fang
authors.initials: HF
authors.lastname: Sun
authors.forename: Shao-Nong
authors.initials: SN
authors.lastname: Chen
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
authors.forename: Zhong-Wen
authors.initials: ZW
authors.lastname: Lin
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D019686:Lamiaceae / Q000737:chemistry*; D007941:Leukemia P388; D008175:Lung Neoplasms; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C459122:buddlejasaponin I; C459123:buddlejasaponin Ia; C459121:craniosaponin A