Infection of Aotus and Saimiri monkeys with Plasmodium gonderi.
Attempts were made to infect 4 species of New World monkeys (Saimiri boliviensis, Aotus nancymai, A. vociferans, A. azarae boliviensis) with Plasmodium gonderi, a malaria parasite of African monkeys. Sporozoites were obtained from Anopheles dirus or A. stephensi mosquitoes that fed on an infected rhesus monkey (Macaca mulatta). Inoculation of sporozoites was by injection of dissected sporozoites by either the intravenous or intrahepatic routes, or by mosquito bite. Liver biopsies done 7 or 8 days after sporozoite inoculation showed that hepatocytes of all 4 species of these New World monkeys supported exoerythrocytic stages of P. gonderi, but daily blood film examination during a 60-day observation period failed to detect blood stages of the parasite.
Sullivan
JoAnn S
JS
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
Jennings
Veronica M
VM
Guarner
Jeanette
J
Noland
Gregory S
GS
Kendall
Jesse
J
Collins
William E
WE
D000818:Animals; D001706:Biopsy / Q000662:veterinary; D002427:Cebidae; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000469:parasitology / Q000473:pathology; D008099:Liver / Q000469:parasitology; D008288:Malaria / Q000097:blood / Q000469:parasitology / Q000635:transmission / Q000662:veterinary*; D008992:Monkey Diseases / Q000097:blood / Q000469:parasitology* / Q000635:transmission; D010961:Plasmodium / Q000254:growth & development*