title: QUICKI is useful for following improvements in insulin sensitivity after therapy in patients with type 2 diabetes mellitus.
abstract: To investigate whether quantitative insulin sensitivity check index (QUICKI) would be useful as an index of insulin resistance during the clinical course of type 2 diabetes mellitus, correlation between QUICKI and the index of the euglycemic hyperinsulinemic clamp study [clamp insulin resistance (clamp IR)] was evaluated in 60 patients with type 2 diabetes mellitus before and after treatment. The therapy program consisted of diet (1440-1720 kcal/d) and exercise (walking 10,000 steps daily) for 6 wk. QUICKI and clamp IR were significantly correlated before (r = 0.598, P < 0.0001) and after (r = 0.583, P < 0.0001) treatment. Neither the slope nor the intercept of the linear correlation between QUICKI and clamp IR measured before treatment was significantly different from those measured after treatment (slopes; F = 0.002, P = 0.96, intercepts; F = 2.65, P = 0.11). During treatment, the values of both QUICKI (8% change; P < 0.0001) and clamp IR (38% change; P < 0.0001) significantly increased and their changes were significantly correlated (r = 0.415, P < 0.01). In conclusion, QUICKI may become a useful method for the follow-up of insulin resistance during the treatment of patients with type 2 diabetes mellitus.
authors.affiliation: Third Department of Internal Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. katuki-a@clin.medic.mie-u.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Katsuki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Sumida
authors.forename: Esteban C
authors.initials: EC
authors.lastname: Gabazza
authors.forename: Shuichi
authors.initials: S
authors.lastname: Murashima
authors.forename: Hideki
authors.initials: H
authors.lastname: Urakawa
authors.forename: Kohei
authors.initials: K
authors.lastname: Morioka
authors.forename: Nagako
authors.initials: N
authors.lastname: Kitagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Rika
authors.initials: R
authors.lastname: Araki-Sasaki
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Hori
authors.forename: Kaname
authors.initials: K
authors.lastname: Nakatani
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yano
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Adachi
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000503:physiopathology* / Q000628:therapy; D004704:Endocrinology / Q000379:methods*; D005081:Exercise Therapy; D005260:Female; D005500:Follow-Up Studies; D015309:Glucose Clamp Technique; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged