title: Distribution of fibronectin, laminin and collagen type IV in the materno-fetal boundary zone of the developing mouse placenta. Experimental study.
abstract: OBJECTIVE
  The objective of this study is to demonstrate the distribution of extracellular matrix components of fibronectin, laminin and collagen type IV in the materno-fetal boundary zone of the developing mouse placenta.
  
  
  METHODS
  Mice fetuses and placentas were removed serially every day until the 19th gestational day. Implantation sites were processed and stained by an immunohistochemical method by specific antiserums to fibronectin, laminin and collagen type IV. The distribution of the extracellular matrix components in cytotrophoblasts and giant cells of the developing mouse placenta were determined under light microscope.
  
  
  RESULTS
  Fibronectin, laminin and collagen type IV immunostaining demonstrated a dynamic relationship changing day by day after the conception. At the 16th day cytotrophoblasts and giant cells were all positively stained by the extracellular matrix components.
  
  
  CONCLUSIONS
  This study demonstrates that the regions of the developing mouse placenta produce specialized extracellular matrices which may contain different ratios of these polypeptides.
authors.affiliation: Department of Anatomy, Faculty of Medicine, Ege University, Izmir, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Saylam
authors.forename: N
authors.initials: N
authors.lastname: Ozdemir
authors.forename: I M
authors.initials: IM
authors.lastname: Itil
authors.forename: F
authors.initials: F
authors.lastname: Sendag
authors.forename: M C
authors.initials: MC
authors.lastname: Terek
mesh_terms: D000818:Animals; D024141:Collagen Type IV / Q000378:metabolism*; D005260:Female; D005353:Fibronectins / Q000378:metabolism*; D005865:Gestational Age; D015726:Giant Cells / Q000378:metabolism; D007150:Immunohistochemistry / Q000379:methods; D007797:Laminin / Q000378:metabolism*; D051379:Mice; D010920:Placenta / Q000166:cytology / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D013194:Staining and Labeling; D014018:Tissue Distribution; D014327:Trophoblasts / Q000378:metabolism
chemical_list: D024141:Collagen Type IV; D005353:Fibronectins; D007797:Laminin