Preservation of paraoxonase activity by wine flavonoids: possible role in protection of LDL from lipid peroxidation.
Paraoxonase is an esterase physically associated with HDL, and its activity has been shown to be inversely related to the risk of cardiovascular diseases. We have shown that paraoxonase can hydrolyze specific lipid peroxides in oxidized lipoproteins and in atherosclerotic lesions. Paroxonase was shown to be inactivated by oxidative stress. Consumption of wine flavonoids was shown to preserve paraoxonase activity by reducing the oxidative stress in apolipoprotein E-deficient mice, thereby contributing to paraoxonase hydrolytic activity on lipid peroxides in oxidized lipoproteins and atherosclerotic lesions.
Fuhrman
Bianca
B
Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, Haifa, Israel. fuhrman@tx.technion.ac.il
Aviram
Michael
M
D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics; D043303:Aryldialkylphosphatase; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D002316:Cardiotonic Agents / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology; D004950:Esterases / Q000378:metabolism*; D005419:Flavonoids / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics; D010084:Oxidation-Reduction / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology; D011108:Polymers / Q000494:pharmacology; D011794:Quercetin / Q000494:pharmacology; D012016:Reference Values; D014920:Wine
D001057:Apolipoproteins E; D002316:Cardiotonic Agents; D005419:Flavonoids; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; D010636:Phenols; D011108:Polymers; D002392:Catechin; D011794:Quercetin; D004950:Esterases; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase