Effect of topical ophthalmic latanoprost on intraocular pressure in normal horses.
The ocular effects of latanoprost ophthalmic solution were evaluated in two studies, with eight horses in each study. One eye of each horse was treated with latanoprost ophthalmic solution once daily for 5 days, and the opposite eye received a control solution of sterile eyewash. Intraocular pressure and pupillary diameter were measured daily for 5 days after treatment. Latanoprost had no significant effect on intraocular pressure or pupillary diameter in normal horse eyes compared with control eyes in these studies. Placement of an eyelid nerve block resulted in significantly lower intraocular pressure.
Davidson
Harriet J
HJ
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA.
Pinard
Chantale L
CL
Keil
Susan M
SM
Brightman
Alan H
AH
Sargeant
Jan M
JM
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005901:Glaucoma / Q000517:prevention & control / Q000662:veterinary; D006734:Horse Diseases / Q000517:prevention & control; D006736:Horses / Q000502:physiology*; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011680:Pupil / Q000187:drug effects; D012016:Reference Values
D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost