title: Value of Doppler index combining systolic and diastolic myocardial performance in predicting cardiopulmonary exercise capacity in patients with congestive heart failure: effects of dobutamine.
abstract: OBJECTIVE
  Doppler-derived myocardial performance index (MPI), a measure of combined systolic and diastolic myocardial performance, was assessed at rest and after low-dose dobutamine administration in patients with idiopathic or ischemic dilated cardiomyopathy. MPI also was correlated with other conventional echocardiographic indexes of left ventricular (LV) function, and its ability to assess cardiopulmonary exercise capacity in those patients was investigated.
  
  
  METHODS
  A tertiary-care, university heart failure clinic.
  
  
  METHODS
  Forty-two consecutive patients (27 men; mean [+/- SD] age, 57 +/- 10 years) with heart failure (New York Heart Association [NYHA] class, II to IV) who had received echocardiographic diagnoses of dilated cardiomyopathy. Coronary angiography distinguished the cause of dilated cardiomyopathy.
  
  
  METHODS
  Low-dose IV dobutamine was infused after patients underwent a baseline echocardiographic study. All patients also underwent a cardiopulmonary exercise test using a modified Naughton protocol.
  
  
  RESULTS
  Advanced NYHA class and restrictive LV filling pattern were associated with higher index values. A negative correlation was found between MPI and LV stroke volume, cardiac output, early filling/late filling velocity ratio, and late LV filling velocity, as well as oxygen uptake at peak exercise (r = -0.550; p < 0.001) and at the anaerobic threshold (r = -0.490; p = 0.002). Dobutamine administration produced an improvement in MPI, reducing its value and decreasing the isovolumic relaxation and contraction times. Stepwise regression analysis revealed that the rest index and the late LV filling velocity were the only independent predictors of cardiopulmonary exercise capacity.
  
  
  CONCLUSIONS
  MPI correlates inversely with LV performance, reflects disease severity, and is a useful complimentary variable in the assessment of cardiopulmonary exercise performance in patients with heart failure.
authors.affiliation: Cardiology Department, Heraklion University Hospital, Stavrakia, Crete, Greece.
authors.forename: Fragiskos I
authors.initials: FI
authors.lastname: Parthenakis
authors.forename: Marina K
authors.initials: MK
authors.lastname: Kanakaraki
authors.forename: Emmanuel M
authors.initials: EM
authors.lastname: Kanoupakis
authors.forename: Emmanuel I
authors.initials: EI
authors.lastname: Skalidis
authors.forename: George F
authors.initials: GF
authors.lastname: Diakakis
authors.forename: Olvia K
authors.initials: OK
authors.lastname: Filippou
authors.forename: Panos E
authors.initials: PE
authors.lastname: Vardas
mesh_terms: D000318:Adrenergic beta-Agonists; D004280:Dobutamine; D015150:Echocardiography, Doppler; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000503:physiopathology; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D011237:Predictive Value of Tests; D012720:Severity of Illness Index
chemical_list: D000318:Adrenergic beta-Agonists; D004280:Dobutamine