title: Regiospecific synthesis of bicyclo- and heterobicyclo-gem-difluorocyclobutenes using functionalized fluoroallenes and a novel Mo-catalyzed intramolecular [2 + 2] cycloaddition reaction.
abstract: The first synthesis of functionalized gem-difluoroallenes 4 served as platform for an unprecedented molybdenum-catalyzed intramolecular allene-alkyne [2 + 2]-cycloaddition that produced 6, a hitherto unknown class of bicyclo- and heterobicyclo-CF2-containing cyclobutenes.
authors.affiliation: Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, Massachusetts 02747, USA.
authors.forename: Qilong
authors.initials: Q
authors.lastname: Shen
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis*; D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D013379:Substrate Specificity
chemical_list: D000466:Alkadienes; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003503:Cyclobutanes; D006845:Hydrocarbons, Fluorinated; C025947:propadiene