[Relationship between interferon priming effect and functional activity of human blood cells].
Relationship between the priming effects of interferon (IFN)-alpha and -gamma and the standard IFN production by peripheral blood leukocytes was evaluated in 25 volunteers (13 men and 12 women, mean age 35.3 years). Priming of IFN-alpha and IFN-gamma production positively correlated with the standard IFN-alpha and IFN-gamma synthesis, respectively. On the other hand, primed production of IFN-alpha negatively correlated with that of IFN-gamma. Possible role of types I and II IFN interactions in the maintenance of physiological regulatory balance is discussed.
Cheknev
S B
SB
Amchenkova
A M
AM
Narovlianskiĭ
A N
AN
D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000494:pharmacology; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D007371:Interferon-gamma / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000998:Antiviral Agents; D016898:Interferon-alpha; D007371:Interferon-gamma
Zavisimost' praĭmiruiushchego éffekta interferona ot funktsional'noĭ aktivnosti kletok krovi cheloveka.