title: Paraoxonase Gln-Arg(192) and Leu-Met(55) gene polymorphisms and enzyme activity in a population with a low rate of coronary heart disease.
abstract: OBJECTIVE
  To assess whether paraoxonase (PON1) polymorphisms at positions 55 and 192 and/or their phenotypic expressions influence the risk of myocardial infarction (MI) in Spanish population.
  
  
  METHODS
  Two hundred and fifteen male survivors of a MI and their age-matched controls were included in the study. Lipids, apolipoproteins (apo) A-I and B, PON1 activity on paraoxon and phenylacetate and PON1 polymorphisms were determined.
  
  
  RESULTS
  Genotype distribution was similar in patients and controls. Enzyme activities were lower in patients, but multiple logistic regression analysis did not show any independent association with a higher risk of MI.
  
  
  CONCLUSIONS
  None of the PON1 polymorphisms or their corresponding measured activities are independent risk factors for MI in our population.
authors.affiliation: Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Reus, Spain.
authors.forename: Natàlia
authors.initials: N
authors.lastname: Ferré
authors.forename: Mònica
authors.initials: M
authors.lastname: Tous
authors.forename: Antoni
authors.initials: A
authors.lastname: Paul
authors.forename: Alberto
authors.initials: A
authors.lastname: Zamora
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Vendrell
authors.forename: Alfredo
authors.initials: A
authors.lastname: Bardají
authors.forename: Jordi
authors.initials: J
authors.lastname: Camps
authors.forename: Cristobal
authors.initials: C
authors.lastname: Richart
authors.forename: Jorge
authors.initials: J
authors.lastname: Joven
mesh_terms: D000368:Aged; D019943:Amino Acid Substitution; D043303:Aryldialkylphosphatase; D003327:Coronary Disease / Q000201:enzymology / Q000453:epidemiology* / Q000235:genetics; D004950:Esterases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D004950:Esterases; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human