Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer.
We have found that EEF1A2, the gene encoding protein elongation factor EEF1A2 (also known as eEF-1 alpha 2), is amplified in 25% of primary ovarian tumors and is highly expressed in approximately 30% of ovarian tumors and established cell lines. We have also demonstrated that EEF1A2 has oncogenic properties: it enhances focus formation, allows anchorage-independent growth and decreases the doubling time of rodent fibroblasts. In addition, EEF1A2 expression made NIH3T3 fibroblasts tumorigenic and increased the growth rate of ES-2 ovarian carcinoma cells xenografted in nude mice. Thus, EEF1A2 and the process of protein elongation are likely to be critical in the development of ovarian cancer.
Anand
Nisha
N
Hamilton Regional Cancer Centre, Room 450, 699 Concession Street, Hamilton, Ontario, L8V 5C2, Canada.
Murthy
Sabita
S
Amann
Gudrun
G
Wernick
Meredith
M
Porter
Lisa A
LA
Cukier
I Howard
IH
Collins
Colin
C
Gray
Joe W
JW
Diebold
Joachim
J
Demetrick
Doug J
DJ
Lee
Jonathan M
JM
D016475:3T3 Cells; D000818:Animals; D002277:Carcinoma / Q000235:genetics; D002455:Cell Division; D002460:Cell Line; D002890:Chromosomes, Human, Pair 20; D005260:Female; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D010051:Ovarian Neoplasms / Q000235:genetics*; D020648:Peptide Elongation Factor 1 / Q000235:genetics*; D011401:Promoter Regions, Genetic; D051381:Rats; D014407:Tumor Cells, Cultured
C503234:EEF1A2 protein, human; C503235:Eef1a2 protein, mouse; C503236:Eef1a2 protein, rat; D020648:Peptide Elongation Factor 1