title: [Stereologic study of the cerebellar Purkinje cells submitted to alcoholic intoxication in Wistar rats].
abstract: BACKGROUND
  to analyze the effect of the alcohol on the cells of Purkinje.
  
  
  METHODS
  Wistar rats received alcoholic solutions orally in different concentrations 4%, 12% and 24%. The animals were sacrificed with 4, 8 and 12 weeks and the cerebella were randomly cut and embedded in paraffin. Sections of 6 micrometer (H&E) were stereologically analyzed.
  
  
  RESULTS
  The differences among the density for area and density of surface of the cells of Purkinje of all of the experimental groups (E) and the respective controls (C) were significant. With 12 weeks the cell of Purkinje volume density decreased among the groups C and E in the concentrations of 4% and 12%, but not for the concentration of 24%, probably due to smaller liquid ingestion by the animals.
  
  
  CONCLUSIONS
  The alcohol has toxic effect on the Purkinje cellular body in the three studied concentrations from 4 weeks.
authors.affiliation: Laboratório de Histologia e Embriologia, Departamento de Histologia e Embriologia, Instituto de Biologia Roberto Alcântara Gomes, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Mara Ibis Rodrigues
authors.initials: MI
authors.lastname: Apfel
authors.forename: Charles Alfred
authors.initials: CA
authors.lastname: Esberard
authors.forename: Fabrício Kafury Pereira
authors.initials: FK
authors.lastname: Rodrigues
authors.forename: Fayez Mohamad
authors.initials: FM
authors.lastname: Bahamad Júnior
authors.forename: Rafael Oliveira
authors.initials: RO
authors.lastname: Sillero
mesh_terms: D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D002492:Central Nervous System Depressants / Q000633:toxicity*; D000431:Ethanol / Q000633:toxicity*; D008297:Male; D011689:Purkinje Cells / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol
vernacular_title: Estudo estereológico das células de Purkinje cerebelares submetidas à intoxicação alcoólica em ratos Wistar.