Multiple evanescent white dot syndrome in patients with multifocal choroiditis.
BACKGROUND
Controversy exists as to whether a common causal entity is responsible for multifocal choroiditis (MFC) and multiple evanescent white dot syndrome (MEWDS). It is commonly known that patients with MEWDS can later develop manifestations of MFC, but the reverse is rarely seen.


OBJECTIVE
To report cases of MEWDS in patients previously diagnosed with MFC.


METHODS
Retrospective case series.


METHODS
Four female patients 29 to 34 years old.


METHODS
The charts of four patients with acute unilateral onset of MEWDS and evidence of previous MFC were examined retrospectively.


METHODS
Photographic and angiographic interpretation of fundus appearance.


RESULTS
At the time of diagnosis with typical MEWDS, one patient had a documented previous episode of acute MFC; one patient had previous bilateral choroidal neovascularization associated with discrete, posterior atrophic scars; and two patients had peripheral discrete chorioretinal pigmented lesions and peripapillary atrophy.


CONCLUSIONS
MEWDS may occur after MFC. Now that both directions of disease progression, MFC to MEWDS and MEWDS to MFC, have been well documented, it is likely that there is a common host susceptibility between these two distinct clinical diseases, if not a common pathogenesis.
Bryan
Richard G
RG
LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10021, USA.
Freund
K Bailey
KB
Yannuzzi
Lawrence A
LA
Spaide
Richard F
RF
Huang
Sheau J
SJ
Costa
Danielle L
DL
D000328:Adult; D002833:Choroiditis / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D010781:Photography; D012164:Retinal Diseases / Q000175:diagnosis / Q000209:etiology*; D012189:Retrospective Studies; D013577:Syndrome