Triplet repeat polymorphism in the transmembrane region of the MICA gene in celiac disease.
Celiac disease (CD) is characterized by a striking expansion of gamma delta T cells in the intestine. These cells interact with MICA, a cell surface protein encoded by a major histocompatibility complex gene. We investigated whether MICA gene polymorphism could contribute to susceptibility to CD. DNA typing for HLA-DR, DQA1, DQB1, TNF-308, TNFa, TNFb and a triplet repeat polymorphism in the transmembrane region of the MICA gene were carried out. We performed case-control stratified association studies and transmission disequilibrium tests. Our results indicate that although there is no primary association between MICA polymorphism and CD, there is, in addition to HLA-DQ, a second susceptibility locus on the 8.1 ancestral haplotype in strong linkage disequilibrium with MICA A5.1 allele.
Fernandez
L
L
Deparment of immunology, San Carlos University Hospital, Madrid, Spain.
Fernandez-Arquero
M
M
Gual
L
L
Lazaro
F
F
Maluenda
C
C
Polanco
I
I
Figueredo
M A
MA
Gomez de la Concha
Emilio
E
D000483:Alleles; D016022:Case-Control Studies; D002446:Celiac Disease / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D013030:Spain; D018911:Trinucleotide Repeats / Q000235:genetics*
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; D008565:Membrane Proteins