title: Mycobacterium tuberculosis CDC1551 is resistant to reactive nitrogen and oxygen intermediates in vitro.
abstract: Resistance to reactive oxygen intermediates and reactive nitrogen intermediates in vitro of a clinical isolate of Mycobacterium tuberculosis (CDC1551) that caused a large outbreak of tuberculosis was compared to that of M. tuberculosis strains CB3.3, H37Rv, H37Ra, Erdman, RJ2E, C.C. 13, and C.C. 22 as well as M. bovis strains Ravenel and BCG. CDC1551 and CB3.3 were significantly more resistant to both hydrogen peroxide (H(2)O(2)) and acidified sodium nitrite than were the other strains tested. This biological phenotype may serve as an in vitro marker for clinical strains of M. tuberculosis likely to cause a large outbreak of tuberculosis.
authors.affiliation: School of Public Health, Division of Infectious Disease, University of California at Berkeley, Berkeley, California 94720, USA.
authors.forename: Marcia A
authors.initials: MA
authors.lastname: Firmani
authors.forename: Lee W
authors.initials: LW
authors.lastname: Riley
mesh_terms: D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007629:Kentucky / Q000453:epidemiology; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D016877:Oxidants / Q000494:pharmacology*; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D012977:Sodium Nitrite / Q000494:pharmacology*; D013714:Tennessee / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000382:microbiology
chemical_list: D016877:Oxidants; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide; D012977:Sodium Nitrite