title: The course of pregnancy in a patient with nail-patella syndrome.
abstract: BACKGROUND
  The nail-patella syndrome is a rare autosomal dominant condition with high penetrance. Pregnancy in such a patient is rare and we believe this to be the first report of a live birth occurring in a patient with nail-patella syndrome.
  
  
  METHODS
  A 25-year-old patient presented in her first pregnancy with nephrotic syndrome associated with characteristic bone abnormalities and nail dysplasia and was later diagnosed to have nail-patella syndrome. In her second pregnancy, the course of her pregnancy was complicated by further deterioration of renal function with superimposed pre-eclampsia resulting in early delivery at 28 weeks.
  
  
  CONCLUSIONS
  Such pregnancies should be regarded as high risk and managed jointly with the renal physician in a tertiary care centre to ensure an optimal outcome to the mother and baby.
authors.affiliation: Department of Obstetrics and Gynaecology, Singapore General Hospital, 1 Hospital Drive, Singapore 169608.
authors.forename: H L
authors.initials: HL
authors.lastname: Chua
authors.forename: L K
authors.initials: LK
authors.lastname: Tan
authors.forename: H K
authors.initials: HK
authors.lastname: Tan
authors.forename: A S A
authors.initials: AS
authors.lastname: Tan
authors.forename: H L
authors.initials: HL
authors.lastname: Choong
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D036861:Delivery, Obstetric / Q000379:methods; D018450:Disease Progression; D005260:Female; D006801:Humans; D009261:Nail-Patella Syndrome / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D009404:Nephrotic Syndrome / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D007752:Obstetric Labor, Premature / Q000209:etiology / Q000628:therapy; D010298:Parity; D010348:Patient Care Team; D011225:Pre-Eclampsia / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D011239:Prednisolone / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000628:therapy*; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk; D011295:Prenatal Care / Q000379:methods
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone