[Gd(DTPA-BDMA)] as a magnetic resonance contrast agent: acute toxicity test and preliminary images.
The new complex of Gd(III) with the 1,7-bis[(N-dimethyl(carbomoyl)methyl)-1,4,7-triazaheptane-1,4,7- triacetate[Gd(DTPA-BDMA)] is a non-ionic paramagnetic complex designed for use as an extracellular magnetic resonance imaging (MRI) contrast agent. The R1 relaxivity value of [Gd(DTPA-BDMA)] is 4.13 +/- 0.2 mM-1S-1, which is similar to that of [Gd(DTPA)]2- (4.08 mM-1S-1). The purpose of this study is to examine the acute toxicity and MRI characteristics of [Gd(DTPA-BDMA)]. Our results show that the lethal dose (LD50) of the [Gd (DTPA-BDMA)] is 10.58 mmol/kg in ICR mice, which is higher than that of [Gd (DTPA)]-2-(6.40 mmol/kg). The MR images demonstrate that the enhancing effect and renal clearance of [Gd(DTPA-BDMA)] are similar to that of [Gd(DTPA)]2- either in control group or CHA (Cheng hepatoma ascites) tumor model in Wistar rats (p > 0.05). These findings indicate that [(DTPA-BDMA)] has similar characteristics of [Gd(DTPA)]2- and has the potential of becoming a safe and reliable magnetopharmaceutical for the extracellular MRI contrast agent.
Sheu
Reu-Sheng
RS
Department of Radiology, and School of Chemistry, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung, 807 Taiwan.
Wang
Yun-Ming
YM
Kuo
Yu-Ting
YT
Cheng
Tsann-Hwang
TH
Jaw
Twei-Shiun
TS
Liu
Gin-Chung
GC
D000818:Animals; D003287:Contrast Media / Q000633:toxicity*; D019786:Gadolinium DTPA / Q000633:toxicity*; D008279:Magnetic Resonance Imaging; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D017208:Rats, Wistar
D003287:Contrast Media; D019786:Gadolinium DTPA