title: Necrotizing fasciitis: report of 39 pediatric cases.
abstract: BACKGROUND
  Necrotizing fasciitis (NF) is a severe, life-threatening soft tissue infection. General features and risk factors for fatal outcome in children are not well known.
  
  
  OBJECTIVE
  To characterize the features of NF in children and the risk factors for fatal outcome.
  
  
  METHODS
  Retrospective, comparative, observational, and longitudinal trial.
  
  
  METHODS
  Dermatology department of a tertiary care pediatric hospital.
  
  
  METHODS
  All patients with clinical and/or histopathological diagnosis of NF seen from January 1, 1971, through December 31, 2000.
  
  
  METHODS
  Incidence, age, sex, number and location of lesions, preexisting conditions, initiating factors, clinical and laboratory features, diagnosis at admission, treatment, evolution, sequelae, and risk factors for fatal outcome.
  
  
  RESULTS
  We examined 39 patients with NF (0.018% of all hospitalized patients). Twenty-one patients (54%) were boys. Mean age was 4.4 years. Single lesions were seen in 30 (77%) of patients, with 21(54%) in extremities. The most frequent preexisting condition was malnutrition in 14 patients (36%). The most frequent initiating factor was varicella in 13 patients (33%). Diagnosis of NF at admission was made in 11 patients (28%). Bacterial isolations in 24 patients (62%) were polymicrobial in 17 (71%). Pseudomonas aeruginosa was the most frequently isolated bacteria; gram-negative isolates, the most frequently associated bacteria. Complications were present in 33 patients (85%), mortality in 7 (18%), and sequelae in 29 (91%) of 32 surviving patients. The significant risk factor related to a fatal outcome was immunosuppression.
  
  
  CONCLUSIONS
  Necrotizing fasciitis in children is frequently misdiagnosed, and several features differ from those of NF in adults. Immunosuppression was the main factor related to death. Early surgical debridement and antibiotics were the most important therapeutic measures.
authors.affiliation: Department of Pediatric Dermatology, National Institute of Pediatrics, Mexico City, Mexico.
authors.forename: Antonio
authors.initials: A
authors.lastname: Fustes-Morales
authors.forename: Pedro
authors.initials: P
authors.lastname: Gutierrez-Castrellon
authors.forename: Carola
authors.initials: C
authors.lastname: Duran-Mckinster
authors.forename: Luz
authors.initials: L
authors.lastname: Orozco-Covarrubias
authors.forename: Lourdes
authors.initials: L
authors.lastname: Tamayo-Sanchez
authors.forename: Ramon
authors.initials: R
authors.lastname: Ruiz-Maldonado
mesh_terms: D000367:Age Factors; D001424:Bacterial Infections / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D001431:Bacteriological Techniques; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D019115:Fasciitis, Necrotizing / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity; D012307:Risk Factors; D012737:Sex Factors; D015996:Survival Rate