title: The effect of demineralized bone matrix gel on bone ingrowth and fixation of porous implants.
abstract: The presence of demineralized bone matrix (DBM) gel did not enhance or accelerate attachment strength or bone ingrowth and resulted in a significant decrease in implant interface attachment strength at 3 weeks. Hydroxyapatite (HA) coating resulted in significant increases in interface shear strength and bone ingrowth compared with non-HA-coated porous implants at all time periods. The HA-coated implants achieved greater attachment strength and bone ingrowth at earlier time periods and maintained greater attachment strength at long-term periods. The results of this study indicate that in the presence of a good bone-implant interference fit, there is no beneficial effect in applying DBM gel to a porous-coated or HA-coated porous implant surface. The small amount that can be applied and the degree of osteoinductivity of DBM seem to preclude it from having a significant biologic effect.
authors.affiliation: Department of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA. scook2@tulane.edu
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Cook
authors.forename: Samantha L
authors.initials: SL
authors.lastname: Salkeld
authors.forename: Laura P
authors.initials: LP
authors.lastname: Patron
authors.forename: Robert L
authors.initials: RL
authors.lastname: Barrack
mesh_terms: D000818:Animals; D001857:Bone Matrix; D004285:Dogs; D017886:Durapatite; D005269:Femur / Q000601:surgery; D016348:Osseointegration; D019736:Prostheses and Implants
chemical_list: D017886:Durapatite