Leukemia eradication and the effect of maturation factor.
As described previously (1), the development of leukemia might be attributable to the deteriorated effect of a maturation factor on the relevant type of the leukemic leukocytes, rather than a certain cellular defect initiated in the individual leukemic leukocytes. Thus, the eradication of the leukemia should depend on re-establishing the effect of the maturation factor, rather than persistent destruction of individual leukemia leukocytes. The most powerful effect of the maturation factor may be exerted throughout the mitotic duplication process of the most immature fibro-blastocysts in an in vitro cell culture. Thus, to achieve leukemia eradication, this specific cell culture, which might indefinitely be duplicating the immature fibro-blastocysts in the lineage of leukemic leukocytes, should be investigated and developed. Additionally, a technical method of extracting the maturation factor for the maturation mitosis of leukemic leukocytes should be devised and developed in the future.
Hirata
Y
Y
Hirata Hospital, Kochi, Japan.
Hirata
S
S
D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008938:Mitosis; D008954:Models, Biological