Design, functional evaluation and biomedical applications of carbohydrate dendrimers (glycodendrimers).
Receptors for carbohydrates of the lectin type are multisubunit and multivalent proteins with many important biological functions. In order to put their unique biological activities into use in biotechnology and biomedicine, efficient carbohydrate ligands of the glycodendrimer type have been constructed. Although these compounds may be branched into the multiple generations, structures bearing four to 16 terminal carbohydrate substituents have proved to be efficient ligands in most lectin systems. These compounds are rapidly finding important practical applications as antitumor and antiinfective compounds.
Bezouska
Karel
K
Department of Biochemistry, Faculty of Science, Charles University Prague, Praha, Czech Republic. bezouska@biomed.cas.cz
D000818:Animals; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001709:Biotechnology / Q000379:methods*; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry; D015195:Drug Design; D037102:Lectins / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D008958:Models, Molecular; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D051381:Rats
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002241:Carbohydrates; D037102:Lectins; D008024:Ligands; D011108:Polymers