Effects of oral monosodium (L)-glutamate on insulin secretion and glucose tolerance in healthy volunteers.
OBJECTIVE
To investigate the effects of glutamate on insulin secretion and glucose tolerance in humans.


METHODS
Monosodium (L)-glutamate (10 g) was given orally in a double-blind placebo-controlled cross-over study to 18 healthy volunteers, aged 19-28 years, with an oral (75 g) glucose load.


RESULTS
The 75 min insulin response (AUC(0,75 min)), up to tmax of glutamate kinetics, was significantly correlated with the AUC(0,75 min) of glutamate concentrations (r=0.485, P=0.049). Glucose tolerance was not affected.


CONCLUSIONS
Oral (L)-glutamate enhances glucose-induced insulin secretion in healthy volunteers in a concentration-dependent manner.
Chevassus
Hugues
H
Section of Clinical Pharmacology, Clinical Investigation Center, Saint-Eloi University Hospital, and Research Unit UPRES EA 1677, Faculty of Medicine, Montpellier, France.
Renard
Eric
E
Bertrand
Gyslaine
G
Mourand
Isabelle
I
Puech
Raymond
R
Molinier
Nathalie
N
Bockaert
Joël
J
Petit
Pierre
P
Bringer
Jacques
J
D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005951:Glucose Tolerance Test; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D012970:Sodium Glutamate / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D012970:Sodium Glutamate