[Metabolic factors in school children population associated with adult cardiovascular mortality. Four provinces' study].
BACKGROUND
Environmental factors in early stages of life may contribute to adult cardiovascular disease. We have examined certain anthropometric and biochemical variables in children aged 6-7 years from four Spanish provinces with high differences in mortality due to ischemic heart disease (IHD).


METHODS
We performed a cross-sectional survey of 1,255 children (50.3% males) attending schools in Cádiz and Murcia provinces with a relatively high IHD mortality and Madrid and Orense provinces with a relatively low IHD mortality. Weight, body mass index (BMI) and prevalence of obesity were analyzed, and plasma glucose and lipid levels were measured by standardized methods.


RESULTS
Compared with children in the two low-IHD-mortality provinces, those in the two high-IHD-mortality provinces had greater weight (p < 0.05) and BMI (p < 0.01) and higher prevalence of obesity (p < 0.01). Moreover, they had significantly higher (p < 0.01) plasma glucose, triglyceride and apo A-I levels.


CONCLUSIONS
The higher prevalence of overweight and obesity, along with higher plasma glucose and triglyceride levels, in provinces with high coronary artery disease mortality indicates that children from these provinces are metabolically different from those in provinces with low coronary artery disease mortality. These alterations may thus contribute to the different IHD mortality in adulthood.
Garcés
Carmen
C
Unidad de Lípidos, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain.
Lasunción
Miguel Angel
MA
Ortega
Henar
H
López Cubero
Luis
L
Benavente
Mercedes
M
Rubio
Rafael
R
Del Barrio
José L
JL
Rodríguez Artalejo
Fernando
F
Gómez Coronado
Diego
D
Oya
Manuel de
Md
D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000401:mortality*; D002648:Child; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000150:complications*; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D001786:Blood Glucose; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol
Factores metabólicos en la población escolar asociados a mortalidad cardiovascular en los adultos. Estudio Cuatro Provincias.