title: Whole body FDG-PET for the evaluation and staging of small cell lung cancer: a preliminary study.
abstract: [F18]-2-deoxy-2fluoro-D-glucose positron emission tomography (FDG-PET) is increasingly used in the diagnosis and staging of lung cancer. Despite its positive performance characteristics in non-small cell lung cancer (NSCLC), the role of FDG-PET in the staging of small cell lung cancer (SCLC) remains to be determined. We designed a prospective study to address this question. Eighteen patients with SCLC were enrolled prospectively to undergo total body FDG-PET in addition to conventional staging procedures (chest computed tomography (CT), abdominal CT, cranial CT or magnetic resonance imaging (MRI), and bone scan/bone marrow biopsy). The agreement between FDG-PET and conventional staging modalities in identifying the presence or absence of metastatic disease was compared using the Veterans Administration (VA) cooperative staging system for staging. Overall staging by FDG-PET agreed with conventional staging exams in 15/18 (83%) patients (kappa=0.67), which included eight extensive and seven limited cases. FDG-PET showed more extensive disease in two of the three patients for which FDG-PET and conventional staging disagreed. These data suggest that total body FDG-PET may be useful in the staging, treatment planning, and prognostication of SCLC. Whether FDG-PET will replace other more established staging modalities remains to be determined by larger prospective randomized controlled studies.
authors.affiliation: Department of Medicine, Section of Pulmonary and Critical Care, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1054, USA. rchin@wfubmc.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Chin
authors.forename: Trent W
authors.initials: TW
authors.lastname: McCain
authors.forename: Antonius A
authors.initials: AA
authors.lastname: Miller
authors.forename: Donnie P
authors.initials: DP
authors.lastname: Dunagan
authors.forename: Jose
authors.initials: J
authors.lastname: Acostamadiedo
authors.forename: L
authors.initials: L
authors.lastname: Douglas Case
authors.forename: Beth A
authors.initials: BA
authors.lastname: Harkness
authors.forename: Lee P
authors.initials: LP
authors.lastname: Adler
authors.forename: Edward F
authors.initials: EF
authors.lastname: Haponik
mesh_terms: D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009367:Neoplasm Staging; D010347:Patient Care Planning; D011379:Prognosis; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18