title: Stabilization of polymerized vesicular systems: an application of the dynamic molecular shape concept.
abstract: A series of glycolipid surfactants derived from Tris(hydroxymethyl)acrylamidomethane (THAM) and bearing hydrocarbon or perfluorocarbon tails and an acryloyl group attached to their polar head was prepared to explore the aqueous behavior of the supramolecular systems they form. The dispersion of surfactants was achieved in water under ultrasonication conditions. Hydrocarbon compounds give heterogeneous vesicular assemblies. In the case of perfluorocarbon derivatives homogeneous vesicles were obtained. However after 1-day storage, all these systems fuse. To stabilize these vesicles, polymerization by ultra violet (UV) irradiation was carried out. During this reaction, a precipitation in water was observed for the hydrocarbon surfactants, whereas fluorocarbon structures provide stable vesicles without any alteration of their size. According to these results, the polymerization process was achieved, in the case of hydrocarbon glycolipid, in the presence of different cosurfactants bearing a single hydrocarbon tail or a polyhydroxylated head and a cholesterol terminus. In such conditions, homogeneous stable vesicles were prepared. Moreover, the THAM derived telomers bearing a cholesterol terminus were able to stabilize and reduce the size of vesicles formed with synthetic glycolipid surfactants. The drug encapsulation ability of these systems was investigated by measurement of the release kinetics of a fluorescent dye, carboxyfluorescein (CF), before and after polymerization.
authors.affiliation: Laboratoire de Chimie Bioorganique et des Systèmes Moléculaires Vectoriels, Université d'Avignon et des Pays de Vaucluse, 33 rue Louis Pasteur, Avignon, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Wathier
authors.forename: Ange
authors.initials: A
authors.lastname: Polidori
authors.forename: Karine
authors.initials: K
authors.lastname: Ruiz
authors.forename: Anne Sylvie
authors.initials: AS
authors.lastname: Fabiano
authors.forename: Bernard
authors.initials: B
authors.lastname: Pucci
mesh_terms: D002152:Calorimetry, Differential Scanning; D009682:Magnetic Resonance Spectroscopy; D008854:Microscopy, Electron; D011108:Polymers / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry; D014325:Tromethamine / Q000737:chemistry
chemical_list: D011108:Polymers; D013501:Surface-Active Agents; D014325:Tromethamine