title: Effects of oral monosodium (L)-glutamate on insulin secretion and glucose tolerance in healthy volunteers.
abstract: OBJECTIVE
  To investigate the effects of glutamate on insulin secretion and glucose tolerance in humans.
  
  
  METHODS
  Monosodium (L)-glutamate (10 g) was given orally in a double-blind placebo-controlled cross-over study to 18 healthy volunteers, aged 19-28 years, with an oral (75 g) glucose load.
  
  
  RESULTS
  The 75 min insulin response (AUC(0,75 min)), up to tmax of glutamate kinetics, was significantly correlated with the AUC(0,75 min) of glutamate concentrations (r=0.485, P=0.049). Glucose tolerance was not affected.
  
  
  CONCLUSIONS
  Oral (L)-glutamate enhances glucose-induced insulin secretion in healthy volunteers in a concentration-dependent manner.
authors.affiliation: Section of Clinical Pharmacology, Clinical Investigation Center, Saint-Eloi University Hospital, and Research Unit UPRES EA 1677, Faculty of Medicine, Montpellier, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: Chevassus
authors.forename: Eric
authors.initials: E
authors.lastname: Renard
authors.forename: Gyslaine
authors.initials: G
authors.lastname: Bertrand
authors.forename: Isabelle
authors.initials: I
authors.lastname: Mourand
authors.forename: Raymond
authors.initials: R
authors.lastname: Puech
authors.forename: Nathalie
authors.initials: N
authors.lastname: Molinier
authors.forename: Joël
authors.initials: J
authors.lastname: Bockaert
authors.forename: Pierre
authors.initials: P
authors.lastname: Petit
authors.forename: Jacques
authors.initials: J
authors.lastname: Bringer
mesh_terms: D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005951:Glucose Tolerance Test; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D012970:Sodium Glutamate / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D012970:Sodium Glutamate