Oncogenic tyrosine kinases and the DNA-damage response.
Oncogenic tyrosine kinases (OTKs) are involved in the induction of many types of tumour, including haematological malignancies and cancers of the breast, prostate, colon and lung. Neoplastic cells that express OTKs are usually resistant to apoptosis that is induced by DNA-damaging agents, such as cytostatic drugs and irradiation, and they display genomic instability. So, what are the mechanisms involved, and what is the potential for overcoming OTK-mediated resistance in the clinic?
Skorski
Tomasz
T
Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA. tskorski@astro.temple.edu
D017209:Apoptosis; D004249:DNA Damage; D004273:DNA, Neoplasm / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D014466:Ultraviolet Rays
D004273:DNA, Neoplasm; D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases