title: Ofuji's disease: a report on 20 patients with clinical and histopathologic analysis.
abstract: BACKGROUND
  Ofuji's disease, also referred to as classic eosinophilic pustular folliculitis, is a rare dermatosis of unknown origin for which there is no uniformly effective treatment.
  
  
  OBJECTIVE
  Twenty patients with Ofuji's disease (classic eosinophilic pustular folliculitis) evaluated in our department from January 1978 to June 1999 were studied clinically and histopathologically. Laboratory data, treatments, and clinical courses were evaluated in 12 of these individuals.
  
  
  RESULTS
  Nissl modified staining revealed moderate increases of mast cells around hair follicles and sebaceous glands in all 20 patients; the majority of the infiltrating mast cells were tryptase-positive and chymase-negative. Eight of 11 patients treated with oral indomethacin responded completely.
  
  
  CONCLUSIONS
  Indomethacin is an effective therapy for Ofuji's disease. Tryptase-positive and chymase-negative mast cells might play some role in the pathogenesis of Ofuji's disease.
authors.affiliation: Department of Dermatology, Tokyo Women's Medical University, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Ishiguro
authors.forename: Etsuko
authors.initials: E
authors.lastname: Shishido
authors.forename: Reiko
authors.initials: R
authors.lastname: Okamoto
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Igarashi
authors.forename: Mina
authors.initials: M
authors.lastname: Yamada
authors.forename: Makoto
authors.initials: M
authors.lastname: Kawashima
mesh_terms: D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001132:Arm; D001415:Back; D003622:Dapsone / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D005260:Female; D005499:Folliculitis / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D005528:Foot; D006801:Humans; D007150:Immunohistochemistry; D007213:Indomethacin / Q000627:therapeutic use; D007564:Japan / Q000453:epidemiology; D008297:Male; D008407:Mast Cells / Q000276:immunology; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000627:therapeutic use; D013909:Thorax; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003622:Dapsone; D011239:Prednisolone; D008911:Minocycline; D013420:Sulfamethoxazole; D007213:Indomethacin