Chronic evaluation of the Cleveland Clinic CorAide left ventricular assist system in calves.
The Cleveland Clinic CorAide left ventricular assist system is based on a third-generation, implantable, centrifugal pump in which a rotating assembly is suspended fully. To evaluate chronic in vivo system performance and biocompatibility, the CorAide blood pump was implanted in 18 calves for either 1 month or 3 months. Hemodynamics were stable in all calves with a mean pump flow of 5.9 +/- 1.2 L/min and a mean systemic arterial pressure of 98 +/- 5 mm Hg. There were no incidences of bleeding, organ dysfunction, or mechanical failure in any of the 18 calves. Hemolysis occurred in only 1 calf due to outflow graft stenosis. Thrombus inside the pump, seen in 4 of the first 6 cases, was totally eliminated by a final redesign in the remaining cases, including the last 6 implants conducted without anticoagulation therapy. The CorAide blood pump demonstrated good biocompatibility and reliable, effective system performance.
Fukamachi
Kiyotaka
K
Department of Biomedical Engineering and Biological Resources Unit, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A.
Ochiai
Yoshie
Y
Doi
Kazuyoshi
K
Massiello
Alex L
AL
Medvedev
Alexander L
AL
Horvath
David J
DJ
Gerhart
Renee L
RL
Chen
Ji-Feng
JF
Krogulecki
Alexandra Y
AY
Takagaki
Masami
M
Howard
Michael W
MW
Kopcak
Michael W
MW
Golding
Leonard A R
LA
D000818:Animals; D002417:Cattle; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology; D011474:Prosthesis Design; D015203:Reproducibility of Results; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology / Q000628:therapy*