title: Cardiac apoptosis: from organ failure to allograft rejection.
abstract: Cardiac myocyte apoptosis has been extensively studied in the last few years. Increased interest in the field stems from the hope that pharmacological manipulation of apoptosis may become a valuable tool for preventing excessive cell death observed in different pathological conditions. This paper is not intended as a comprehensive overview of current research about life and death in the cardiovascular system, but rather as a concise update on new developments in areas that were highlighted in a recent series of excellent reviews. A short inventory of unsolved issues concerning the significance of cardiac myocyte loss through apoptosis in both physiological and pathological circumstances is addressed.
authors.affiliation: Department of Cell Biology & Histology, Carol Davila University of Medicine & Pharmacy, Bucharest, Romania. mhinescu@univermed-cdgm.ro
authors.forename: M E
authors.initials: ME
authors.lastname: Hinescu
mesh_terms: D000818:Animals; D017209:Apoptosis; D009202:Cardiomyopathies; D016923:Cell Death; D006084:Graft Rejection; D006333:Heart Failure; D006801:Humans; D008954:Models, Biological; D009206:Myocardium / Q000473:pathology*; D015427:Reperfusion Injury