title: The tubulin ancestor, FtsZ, draughtsman, designer and driving force for bacterial cytokinesis.
abstract: We discuss in this review the regulation of synthesis and action of FtsZ, its structure in relation to tubulin and microtubules, and the mechanism of polymerization and disassembly (contraction) of FtsZ rings from a specific nucleation site (NS) at mid cell. These topics are considered in the light of recent immunocytological studies, high resolution structures of some division proteins and results indicating how bacteria may measure their mid cell point.
authors.affiliation: School of Biological Sciences, University Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Addinall
authors.forename: Barry
authors.initials: B
authors.lastname: Holland
mesh_terms: D001419:Bacteria / Q000235:genetics* / Q000254:growth & development*; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000502:physiology*; D016935:Caulobacter crescentus / Q000235:genetics / Q000254:growth & development / Q000502:physiology; D002453:Cell Cycle; D002455:Cell Division; D003598:Cytoskeletal Proteins; D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000378:metabolism; D005798:Genes, Bacterial; D017017:Methanococcus / Q000737:chemistry; D008870:Microtubules / Q000502:physiology; D008958:Models, Molecular; D014404:Tubulin / Q000235:genetics* / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria; C080466:MinC protein, Bacteria; D014404:Tubulin; D020558:GTP Phosphohydrolases