title: Association of matrilysin expression with progression and poor prognosis in human pancreatic adenocarcinoma.
abstract: The matrix metalloproteinase matrilysin has been implicated in the progression of gastrointestinal and other cancers. The aim of this study was to determine whether matrilysin has clinicopathological and prognostic significance in pancreatic carcinoma. Using immunohistochemistry, we analyzed 39 pancreatic adenocarcinoma tissues for expression of matrilysin. The results were matched with clinicopathological characteristics and patient survival. The relationship of matrilysin expression with p53 expression or cellular proliferation determined by Ki-67 expression was also investigated. Sections with immunostaining signals in more than 30% of carcinoma cells at the invasive front, which were observed in 25 (64%) cases, were judged to be positive for matrilysin. Matrilysin positivity was significantly correlated with infiltrating growth pattern, lymph node metastasis, and postoperative recurrence. Expression of matrilysin was not correlated with either Ki-67 or p53 expression. Patients with matrilysin-positive carcinoma had a significantly shorter overall survival time than did those with matrilysin-negative carcinoma. Our results suggest that matrilysin plays a key role in the progression of pancreatic carcinoma.
authors.affiliation: Internal Medicine, Hokkaido Shoukakika Hospital, Sapporo 065-0042, Japan. pv2h-nkmr@asahi-net.or.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Shouichi
authors.initials: S
authors.lastname: Horita
authors.forename: Naoto
authors.initials: N
authors.lastname: Senmaru
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Miyasaka
authors.forename: Takayuki
authors.initials: T
authors.lastname: Gohda
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Inoue
authors.forename: Miyoshi
authors.initials: M
authors.lastname: Fujita
authors.forename: Takashi
authors.initials: T
authors.lastname: Meguro
authors.forename: Takayuki
authors.initials: T
authors.lastname: Morita
authors.forename: Kazuro
authors.initials: K
authors.lastname: Nagashima
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology; D000368:Aged; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D020783:Matrix Metalloproteinase 7 / Q000378:metabolism*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000201:enzymology / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000201:enzymology* / Q000473:pathology; D011379:Prognosis; D015996:Survival Rate
chemical_list: D020783:Matrix Metalloproteinase 7