Hypophyseal hemorrhage and panhypopituitarism during Puumala Virus Infection: Magnetic Resonance Imaging and detection of viral antigen in the hypophysis.
We describe 3 cases of nephropathia epidemica (NE) that confirm that Puumala virus infection may cause hypophyseal injury. Autopsy revealed a hemorrhagic hypophysis positive for Puumala virus antigen in both neuroendocrine stromal and vascular endothelial cells in 1 patient, and 2 patients developed hypophyseal hemorrhage (diagnosed with magnetic resonance imaging) during or shortly after acute NE, both of whom developed panhypopituitarism.
Hautala
Timo
T
Department of Internal Medicine, University of Oulu, Oulu, FIN-90014 Oulu, Finland. thautala@sun3.oulu.fi
Sironen
Tarja
T
Vapalahti
Olli
O
Pääkkö
Eija
E
Särkioja
Terttu
T
Salmela
Pasi I
PI
Vaheri
Antti
A
Plyusnin
Alexander
A
Kauma
Heikki
H
D000328:Adult; D000956:Antigens, Viral / Q000032:analysis*; D006470:Hemorrhage / Q000175:diagnosis* / Q000209:etiology / Q000821:virology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007018:Hypopituitarism / Q000175:diagnosis* / Q000209:etiology / Q000821:virology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010900:Pituitary Diseases / Q000175:diagnosis / Q000209:etiology / Q000821:virology; D010902:Pituitary Gland / Q000821:virology*; D029262:Puumala virus
D000956:Antigens, Viral