title: Melanin-concentrating hormone and its receptors: state of the art.
abstract: Melanin-concentrating hormone (MCH) is a cyclic neuropeptide of nineteen amino acids in mammals. Its involvement in the feeding behaviour has been well established during the last few years. A first receptor subtype, now termed MCHIR, was discovered in 1999, following the desorphanisation of the SLCI orphan receptor, using either reverse pharmacology or systematic screening of agonist candidates. A second MCH receptor, MCH2R, has been discovered recently, by several groups working on data mining of genomic banks. The molecular pharmacology of these two receptors is only described on the basis of the action of peptides derived from MCH. The present review tentatively summarizes the knowledge on these two receptors and presents the first attempts to discover new classes of antagonists that might have major roles in the control of obesity and feeding behaviour.
authors.affiliation: Division de Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, Croissy-sur-Seine, France. jean.boutin@fr.netgrs.com
authors.forename: Jean A
authors.initials: JA
authors.lastname: Boutin
authors.forename: Thomas
authors.initials: T
authors.lastname: Suply
authors.forename: Valérie
authors.initials: V
authors.lastname: Audinot
authors.forename: Marianne
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Philippe
authors.initials: P
authors.lastname: Beauverger
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Nicolas
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Galizzi
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Fauchère
mesh_terms: D000595:Amino Acid Sequence / Q000502:physiology; D000818:Animals; D005247:Feeding Behavior / Q000502:physiology; D006801:Humans; D007028:Hypothalamic Hormones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008543:Melanins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D010907:Pituitary Hormones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011979:Receptors, Pituitary Hormone / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
chemical_list: D007028:Hypothalamic Hormones; D008543:Melanins; D010907:Pituitary Hormones; D011979:Receptors, Pituitary Hormone; C092274:melanin-concentrating hormone receptor; C019463:melanin-concentrating hormone