Melatonin alleviates jet lag symptoms caused by an 11-hour eastward flight.
The effect of 3 mg of melatonin on the rate of re-entrainment of plasma melatonin rhythm after an 11-h eastward flight was assessed. Eight subjects participated in the study, and underwent 24-h blood samplings once before the flight and twice after the flight. Subjects were exposed to natural zeitgeber outdoors and took 3 mg of malatonin at 20:00 h local time on the days when no blood sampling was done. Antidromic re-entrainment was dominant whereby melatonin administration in the evening promoted re-entrainment. Melatonin accelerated the rate of re-entrainment by 15 min per day and alleviated the jet lag symptoms.
Takahashi
Toshiharu
T
Department of Education, Faculty of Letters, Hosei University, Tokyo, Japan. toshiha@i.hosei.ac.jp
Sasaki
Mitsuo
M
Itoh
Hiroshi
H
Yamadera
Wataru
W
Ozone
Motohiro
M
Obuchi
Keita
K
Hayashida
Ken-Ichi
K
Matsunaga
Naoki
N
Sano
Hidetaka
H
D000328:Adult; D001359:Aviation; D006801:Humans; D007564:Japan; D020179:Jet Lag Syndrome / Q000188:drug therapy*; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D008875:Middle Aged; D009518:New York; D013997:Time Factors
D008550:Melatonin