title: Lack of association between calcium-sensing receptor gene "A986S" polymorphism and bone mineral density in Hungarian postmenopausal women.
abstract: Calcium-sensing receptor (CaSR) is an attractive candidate gene for osteoporosis susceptibility. The CaSR "A986S" genotype has been shown to have an effect on serum calcium. Recently, an association has been reported between the CaSR gene A986S polymorphism and bone mineral density in healthy white girls. In this study, we examined whether CaSR gene A986S polymorphism is associated with decreased bone mass in 230 Hungarian postmenopausal women. From this cohort, 108 osteoporotic patients were compared with 122 healthy control women. Bone mineral density (BMD) was measured at the lumbar spine (L2-4) and femoral neck using dual-energy X-ray absorptiometry. Allele-specific polymerase chain reaction was used to amplify A986S polymorphisms of the CaSR gene. We found no difference in the distribution of different alleles or genotypes between groups (p = 0.762). No significant effect of CaSR genotype on BMD was observed either in the whole population or in the subgroups. Our data do not support the idea that CaSR gene A986S polymorphism has an impact on bone mass.
authors.affiliation: First Department of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: I
authors.initials: I
authors.lastname: Takács
authors.forename: G
authors.initials: G
authors.lastname: Speer
authors.forename: E
authors.initials: E
authors.lastname: Bajnok
authors.forename: A
authors.initials: A
authors.lastname: Tabák
authors.forename: Z
authors.initials: Z
authors.lastname: Nagy
authors.forename: C
authors.initials: C
authors.lastname: Horváth
authors.forename: K
authors.initials: K
authors.lastname: Kovács
authors.forename: P
authors.initials: P
authors.lastname: Lakatos
mesh_terms: D000368:Aged; D000409:Alanine / Q000235:genetics; D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics*; D000704:Analysis of Variance; D015519:Bone Density / Q000235:genetics*; D002118:Calcium / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D005269:Femur / Q000502:physiology; D005838:Genotype; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008159:Lumbar Vertebrae / Q000502:physiology; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D044169:Receptors, Calcium-Sensing; D011956:Receptors, Cell Surface / Q000235:genetics*; D012694:Serine / Q000235:genetics
chemical_list: D044169:Receptors, Calcium-Sensing; D011956:Receptors, Cell Surface; D012694:Serine; D000409:Alanine; D002118:Calcium