Magnetic resonance spectroscopy in multiple sclerosis: window into the diseased brain.
Magnetic resonance spectroscopy provides noninvasive insight into the regional and global biochemical alterations that are concomitants of the dynamic processes that underlie the evolution of fundamental pathologic changes in multiple sclerosis. These include now well-recognized alterations of neuronal biochemical markers that accompany tissue destruction readily visualized by magnetic resonance imaging, but also dynamic changes in several metabolites that indicate pathological processes that precede the magnetic resonance imaging-defined lesion, or completely escape current high-resolution imaging.
Wolinsky
Jerry S
JS
Department of Neurology, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA. jswolinsky@aol.com
Narayana
Ponnada A
PA
D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D001923:Brain Chemistry / Q000502:physiology; D018450:Disease Progression; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009103:Multiple Sclerosis / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D009410:Nerve Degeneration / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D009413:Nerve Fibers, Myelinated / Q000378:metabolism / Q000473:pathology
D015415:Biomarkers