title: A new database of mitochondrial DNA hypervariable regions I and II sequences from 162 Japanese individuals.
abstract: A database of mitochondrial DNA (mtDNA) hypervariable region 1 (HV1) and region 2 (HV2) sequences of the mtDNA control region was established from 162 unrelated Japanese individuals. The random match probability and the genetic diversity for this database were 0.96% and 0.997, respectively. Length heteroplasmy in the C-stretch regions located around position 16189 in HVI and 310 in HV2 was observed in 37% and 38% of the samples, respectively. A strategy using internal sequencing primers was devised to obtain confirmed sequences in these length heteroplasmic individuals. This database, combined with other mtDNA sequence databases from the Japanese population, will permit the significance of mtDNA match results to be properly reported in mtDNA typing casework in Japan.
authors.affiliation: National Research Institute of Police Science, Kashiwa, Chiba, Japan. imaizumi@nrips.go.jp
authors.forename: K
authors.initials: K
authors.lastname: Imaizumi
authors.forename: T J
authors.initials: TJ
authors.lastname: Parsons
authors.forename: M
authors.initials: M
authors.lastname: Yoshino
authors.forename: M M
authors.initials: MM
authors.lastname: Holland
mesh_terms: D001483:Base Sequence; D004272:DNA, Mitochondrial / Q000097:blood / Q000235:genetics*; D030561:Databases, Nucleic Acid / Q000706:statistics & numerical data*; D005554:Forensic Medicine; D014644:Genetic Variation; D006801:Humans; D007564:Japan
chemical_list: D004272:DNA, Mitochondrial