Linkage of Patr-AL to Patr-A and- B in the major histocompatibility complex of the common chimpanzee (Pan troglodytes).
Patr-AL is a recently described gene found only in the common chimpanzee, but closely related in structure to the highly polymorphic Patr-A and HLA-A genes of the chimpanzee and human MHCs, respectively. Unlike Patr-A and HLA-A, the Patr-AL gene has little polymorphism and is not fixed in the chimpanzee genome. To determine whether Patr-AL is located in the MHC or elsewhere, we compared segregation of the Patr-AL gene with segregation of Patr-A and - B alleles in chimpanzee families. The results demonstrate that Patr-AL is an MHC class I gene present on different MHC haplotypes as defined by their combination of Patr-A and B alleles.
Geller
Ron
R
Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305-5126, USA.
Adams
Erin J
EJ
Guethlein
Lisbeth A
LA
Little
Ann-Margaret
AM
Madrigal
J Alejandro
JA
Parham
Peter
P
D000818:Animals; D005260:Female; D005787:Gene Frequency; D005805:Genes, MHC Class I; D008040:Genetic Linkage; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D008297:Male; D002679:Pan troglodytes / Q000235:genetics*; D010375:Pedigree; D018807:Polymorphism, Single-Stranded Conformational
D015395:Histocompatibility Antigens Class I