ACTH-secreting islet cell tumor of the pancreas presenting as bilateral ovarian tumors and Cushing's syndrome.
A 41-year-old woman presented with hirsutism, a pelvic mass, and Cushing's syndrome. Imaging studies revealed bilateral ovarian masses and a solid and cystic mass within the pancreas. Partial pancreatectomy, bilateral oophorectomy, and excision of several peritoneal tumor nodules were performed. Pathological examination revealed a neuroendocrine islet cell tumor of the pancreas with bilateral ovarian metastases. The tumor was immunoreactive for ACTH, chromogranin, neuron-specific enolase, and keratin. The patient received postoperative chemotherapy and has been disease-free for 6 years. To our knowledge, this is the first reported case of an ACTH-secreting pancreatic neuroendocrine tumor presenting as bilateral ovarian metastases.
Oberg
Kerby C
KC
Department of Pathology and Human Anatomy, Loma Linda University and Medical Center, California 92350, USA.
Wells
Karen
K
Seraj
Ibrahim M
IM
Garberoglio
Carlos A
CA
Akin
Marie-Rose M
MR
D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis; D000328:Adult; D002277:Carcinoma / Q000378:metabolism / Q000556:secondary*; D018273:Carcinoma, Islet Cell / Q000378:metabolism / Q000473:pathology*; D053379:Chromogranin A; D002864:Chromogranins / Q000096:biosynthesis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000556:secondary*; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology*
D053379:Chromogranin A; D002864:Chromogranins; D000324:Adrenocorticotropic Hormone