Study on the amount of binding of anti-tumor metal complexes to different target sites of dGMP using trans-[en(2)Os(eta2-H(2))(CF(3)SO(3))](CF(3)SO(3)) in a competitive mode.
In order to investigate the binding sites and the amount of binding of a number of anti-tumor metal complexes (cisplatin, Cp(2)TiCl(2) and (CH(3))(2)SnCl(2)) to target molecule DNA mononucleotides in aqueous solution, a 1H NMR recognition probe, trans-[en(2)Os(eta2-H(2))(CF(3)SO(3))](CF(3)SO(3)), was used in a competitive mode. The minimum percentages of binding of anti-tumor metal complexes to different sites of dGMP were also determined.
Yang
Pin
P
Institute of Molecular Science, Shanxi University, Taiyuan 030006, PR China. yangpin@sxu.edu.cn
Meng
Xiang-Li
XL
Yue
Li-Jun
LJ
Wei
Yi-Bin
YB
D000970:Antineoplastic Agents / Q000378:metabolism*; D001667:Binding, Competitive; D002945:Cisplatin / Q000031:analogs & derivatives / Q000378:metabolism*; D003848:Deoxyguanine Nucleotides / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000378:metabolism*; D015335:Molecular Probes / Q000737:chemistry / Q000378:metabolism*; D013997:Time Factors
D000970:Antineoplastic Agents; D003848:Deoxyguanine Nucleotides; D008670:Metals; D015335:Molecular Probes; C007257:2'-deoxyguanosine 5'-phosphate; D002945:Cisplatin