title: Waist circumference predicts insulin resistance in offspring of diabetic patients.
abstract: The purpose of the study was to identify a good abdominal obesity index for insulin resistance in offspring of diabetic patients. A total of 74 non-diabetic subjects (male =36; female =38) were recruited from a diabetic family study. The waist circumference (W), waist-hip ratio (WHR) and conicity index were used as the abdominal obesity indices. The body mass index (BMI) and indices obtained from bioelectric impedance analysis (BIA) (body fat percentage, fat mass and fat mass index) were used as overall obesity indices. Fasting plasma insulin (FPI), homeostasis model assessment for insulin resistance (HOMA-IR) and Matsuda-Defronzo index from oral glucose tolerance test were chosen as the insulin sensitivity indices. We correlated obesity indices with insulin resistance indices with age and family adjusted. W was closely correlated in both sexes of subjects with Matsuda-DeFronzo index (male, r=-0.661,p<0.001; female, r=-0.419,p=0.026), FPI (male, r=0.614,p=0.001; female, r=0.503,p=0.006) and HOMA-IR (male, r=0.609,p=0.001; female, r=0.472,p=0.011). WHR and its log transformation predicted insulin resistance only in males. BMI as an overall obesity index was in good correlation with Matsuda-DeFronzo index (male, r=-0.646,p<0.001; female, r=-0.469,p=0.012), FPI (male, r=0.711,p<0.001; female, r=0.464,p=0.013) and HOMA-IR (male, r=0.708,p<0.001; female, r=0.469,p=0.012). Overall obesity indices from BIA were similar to BMI to predict insulin resistance. In conclusion, W is a good abdominal obesity predictor of insulin resistance in offspring of diabetic patients in Taiwan.
authors.affiliation: Department of Medicine, Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: C S
authors.initials: CS
authors.lastname: Kuo
authors.forename: C M
authors.initials: CM
authors.lastname: Hwu
authors.forename: S C
authors.initials: SC
authors.lastname: Chiang
authors.forename: L C
authors.initials: LC
authors.lastname: Hsiao
authors.forename: M J
authors.initials: MJ
authors.lastname: Weih
authors.forename: W Y
authors.initials: WY
authors.lastname: Kao
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: C F
authors.initials: CF
authors.lastname: Kwok
authors.forename: L T
authors.initials: LT
authors.lastname: Ho
mesh_terms: D000005:Abdomen; D000273:Adipose Tissue / Q000033:anatomy & histology*; D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D001824:Body Constitution / Q000502:physiology*; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D017097:Electric Impedance; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D011237:Predictive Value of Tests; D012737:Sex Factors; D013624:Taiwan
chemical_list: D001786:Blood Glucose