Effects of platelet membrane glycoprotein polymorphisms on the risk of myocardial infarction in young males.
BACKGROUND
Platelet adhesion and aggregation are mediated by specific platelet membrane glycoproteins GPla/IIa, GPlb alpha, and GPIIb/IIIa, and are essential steps in thrombus formation and development of acute myocardial infarction.


OBJECTIVE
To evaluate the risks exerted by each of the following polymorphisms in young males with AMI: HPA-1a/b in GPIIIa: 807C/T in GPIa; and HPA-2a/b. VNTR and Kozak C/T in GPlb alpha.


METHODS
We conducted a case-control study of 100 young males with first AMI before the age of 53 and 119 healthy controls of similar age. All subjects were tested for the above polymorphisms.


RESULTS
The allele frequencies of each of the platelet polymorphisms were not significantly different between the young man with AMI and the controls. Smoking alone was associated with a 9.97-fold risk, and the presence of at least one metabolic risk factor resulted in a 2.57-fold risk of AMI.


CONCLUSIONS
The platelet glycoproteins polymorphisms studied are not an independent risk factor for AMI.
Rosenberg
Nurit
N
Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel.
Zivelin
Ariella
A
Chetrit
Angela
A
Dardik
Rima
R
Kornbrot
Nurit
N
Freimark
Dov
D
Inbal
Aida
A
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005787:Gene Frequency; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D010980:Platelet Membrane Glycoproteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors
D010980:Platelet Membrane Glycoproteins