[The gastric mucigenous function in the treatment of patients with ulcer with various antisecretory preparations].
The investigation of the gastric mucigenous function in dynamics in the treatment by antisecretory medications was carried out in 120 patients with peptic ulcer disease. The selective Mi-cholinolytic gastrocepine, H2-blockers--Ranitidin and Famotidin, the proton pump inhibitor--Omeprasol, were used in the complex therapy. The mucigenous stomach function was investigated by the biochemical method at the level of sialic acids fractions, glycoproteins, glycosaminoglycans and proteins. It was shown that at the exacerbation of the ulcerative disease the expressed changes in gastric mucus were observed. It was shown, that Mi-cholinolytic gastrocepine has the most effective recovering activity on the gastric mucigenous function. The obtained results expand the possibilities of differential use of antisecretory preparations in ulcerative disease in connection with the gastric mucigenous function and acidity disorders.
Vakhrushev
Ia M
IaM
State Medical Academy, Department of Propedeutics of Internal Diseases, Izhevsk.
Muravtseva
O V
OV
D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D015738:Famotidine / Q000627:therapeutic use; D005260:Female; D005745:Gastric Acidity Determination; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D009853:Omeprazole / Q000627:therapeutic use; D010890:Pirenzepine / Q000627:therapeutic use; D054328:Proton Pump Inhibitors; D011899:Ranitidine / Q000627:therapeutic use; D043643:Receptor, Muscarinic M1; D011976:Receptors, Muscarinic / Q000187:drug effects; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000503:physiopathology
D000897:Anti-Ulcer Agents; D004791:Enzyme Inhibitors; D006635:Histamine H2 Antagonists; D009077:Mucins; D018727:Muscarinic Antagonists; D054328:Proton Pump Inhibitors; D043643:Receptor, Muscarinic M1; D011976:Receptors, Muscarinic; D010890:Pirenzepine; D015738:Famotidine; D011899:Ranitidine; D009853:Omeprazole
Issledovanie slizeobrazuiushcheĭ funktsii zheludka pri lechenii bol'nykh iazvennoĭ bolezn'iu razlichnymi antisekretornymi preparatami.