Correlated bursts of activity in the neonatal hippocampus in vivo.
The behavior of immature cortical networks in vivo remains largely unknown. Using multisite extracellular and patch-clamp recordings, we observed recurrent bursts of synchronized neuronal activity lasting 0.5 to 3 seconds that occurred spontaneously in the hippocampus of freely moving and anesthetized rat pups. The influence of slow rhythms (0.33 and 0.1 hertz) and the contribution of both gamma-aminobutyric acid A-mediated and glutamate receptor-mediated synaptic signals in the generation of hippocampal bursts was reminiscent of giant depolarizing potentials observed in vitro. This earliest pattern, which diversifies during the second postnatal week, could provide correlated activity for immature neurons and may underlie activity-dependent maturation of the hippocampal network.
Leinekugel
Xavier
X
INMED, Institut National de la Santé et de la Recherche Médicale (INSERM) U29, Avenue de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France.
Khazipov
Rustem
R
Cannon
Robert
R
Hirase
Hajime
H
Ben-Ari
Yehezkel
Y
Buzsáki
György
G
D000818:Animals; D000831:Animals, Newborn; D005071:Evoked Potentials; D006624:Hippocampus / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D018408:Patch-Clamp Techniques; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000502:physiology; D017470:Receptors, Glutamate / Q000502:physiology; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D011963:Receptors, GABA-A; D017470:Receptors, Glutamate; D005680:gamma-Aminobutyric Acid