title: Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus.
abstract: Eotaxin/CCL11 is a major chemoattractant for eosinophils and Th2 cells. As such, it represents an attractive target in the treatment of allergic disease. The present study addresses the role of eotaxin/CCL11 during acute and chronic allergic airway responses to the fungus Aspergillus fumigatus. Mice lacking the eotaxin gene (Eo-/-) and wild-type mice (Eo+/+) were sensitized to A. fumigatus and received either an intratracheal challenge with soluble A. fumigatus antigens (acute model) or an intratracheal challenge with live A. fumigatus spores or conidia (chronic model). Airway hyperresponsiveness and eosinophil, but not T cell, recruitment were significantly decreased at 24 h after the soluble allergen in A. fumigatus-sensitized Eo-/- mice compared with similarly sensitized Eo+/+ mice. In contrast, the development of chronic allergic airway disease due to A. fumigatus conidia was not altered by the lack of eotaxin. Together, these data suggest that eotaxin initiates allergic airway disease due to A. fumigatus, but this chemokine did not appear to contribute to the maintenance of A. fumigatus-induced allergic airway disease.
authors.affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
authors.forename: Jane M
authors.initials: JM
authors.lastname: Schuh
authors.forename: Kate
authors.initials: K
authors.lastname: Blease
authors.forename: Steven L
authors.initials: SL
authors.lastname: Kunkel
authors.forename: Cory M
authors.initials: CM
authors.lastname: Hogaboam
mesh_terms: D000208:Acute Disease; D000818:Animals; D001228:Aspergillosis / Q000276:immunology*; D001232:Aspergillus fumigatus; D001249:Asthma / Q000276:immunology / Q000382:microbiology; D016535:Bronchial Hyperreactivity / Q000276:immunology / Q000382:microbiology; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000276:immunology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004804:Eosinophils / Q000276:immunology; D005260:Female; D051379:Mice; D018345:Mice, Knockout; D013047:Specific Pathogen-Free Organisms
chemical_list: C515457:Ccl11 protein, mouse; D054413:Chemokine CCL11; D019742:Chemokines, CC