title: Role of the second immunoglobulin-like loop of nectin in cell-cell adhesion.
abstract: Nectin is a Ca(2+)-independent immunoglobulin (Ig)-like cell-cell adhesion molecule that forms cell-cell adherens junctions cooperatively with E-cadherin in a variety of cells. Nectin has one transmembrane segment and three Ig-like loops in the extracellular region. The first Ig-like loop is essential for the trans-dimer formation of nectin of two neighboring cells, causing cell-cell adhesion. We show here that the second Ig-like loop is essential for the cis-dimer formation of nectin on the same cell, and that the cis-dimer formation is essential for the trans-dimer formation.
authors.affiliation: Department of Molecular Biology and Biochemistry, Faculty of Medicine, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Momose
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Honda
authors.forename: Maiko
authors.initials: M
authors.lastname: Inagaki
authors.forename: Kazuya
authors.initials: K
authors.lastname: Shimizu
authors.forename: Kenji
authors.initials: K
authors.lastname: Irie
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakanishi
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Takai
mesh_terms: D000818:Animals; D019556:COS Cells; D002448:Cell Adhesion / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology*; D002449:Cell Aggregation; D002522:Chlorocebus aethiops; D019281:Dimerization; D007136:Immunoglobulins / Q000494:pharmacology / Q000502:physiology; D051379:Mice; D000075983:Nectins; D017433:Protein Structure, Secondary; D014162:Transfection
chemical_list: D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D000075983:Nectins