[Current therapeutic approaches of neurologic damage in neonatal asphyxia].
Perinatal hypoxiaischaemia is a major cause of mortality and neurological sequelae in term newborn. Modulation of mechanisms leading to brain cell death, in the so-called therapeutic window, may reduce apoptosis and necrosis. Oxidative stress and newborn resuscitation, early postnatal pharmacological treatment and hypothermic neuroprotection are described. Additional controlled prospective trials are warranted on newborns. A combination of neuroprotective agents with synergistic effects could represent a potential treatment strategy.
Marconi
M
M
Unità Operativa Assistenza Neonatale, Azienda Ospedaliera San Camillo-Forlanini, Roma.
D000818:Animals; D001238:Asphyxia Neonatorum / Q000150:complications* / Q000628:therapy*; D001925:Brain Damage, Chronic / Q000209:etiology* / Q000517:prevention & control*; D003080:Cold Temperature; D006801:Humans; D007231:Infant, Newborn; D012151:Resuscitation
Strategie terapeutiche attuali nel danno neurologico del neonato asfittico.