Prematurity in multiple gestations: identification of patients who are at low risk.
OBJECTIVE
The purpose of this study was to evaluate a strategy for the identification of patients with multiple gestations who are at low risk for preterm delivery.


METHODS
A prospective observational study among patients with twin and triplet gestations. At 20 and 24 weeks of gestation, screening for bacterial vaginosis and fetal fibronectin was performed, followed by digital and sonographic assessment of the cervix. The treating physicians were blinded to test results.


RESULTS
At the 24-week examination, specificities for delivery at >32 weeks of gestation for digital examination (92.9%), fetal fibronectin level (93.9%), cervical length on sonographic scan (85.1%), and combined fetal fibronectin level and cervical length (81.3%) did not differ statistically. Negative predictive values for these tests were >or=95%. All tests performed better at 24 weeks of gestation than at 20 weeks of gestation.


CONCLUSIONS
At 24 weeks of gestation, a normal digital examination, a negative fetal fibronectin level, a normal cervical length on sonographic scan, or the combination of a negative fetal fibronectin level and a normal cervical length each confer a similarly high likelihood of delivery at >32 weeks of gestation in women with multiple gestations.
McMahon
Kimberly S
KS
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University Medical School, USA.
Neerhof
Mark G
MG
Haney
Elaine I
EI
Thomas
Hope A
HA
Silver
Richard K
RK
Peaceman
Alan M
AM
D000328:Adult; D002584:Cervix Uteri / Q000000981:diagnostic imaging / Q000502:physiology; D005260:Female; D005312:Fetal Blood; D005353:Fibronectins / Q000097:blood; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D016013:Likelihood Functions; D010808:Physical Examination; D011237:Predictive Value of Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000503:physiopathology; D011272:Pregnancy, Multiple; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014463:Ultrasonography; D016585:Vaginosis, Bacterial / Q000503:physiopathology
D005353:Fibronectins