Plasma catecholamine metabolites in antidepressant-exacerbated mania and psychosis.
We measured plasma free HVA and MHPG in 39 cases of psychosis or mania judged to be caused by antidepressant exacerbation of symptoms. A total of 24 of patients had been receiving selective serotonin reuptake inhibitors (SSRI's). The SSRI group showed a pattern of increased plasma HVA similar to a comparison group of patients with a psychotic/manic relapse secondary to medication non-compliance.
Fortunati
Frank
F
Department of Psychiatry, Yale University, USA.
Mazure
Carolyn
C
Preda
Adrian
A
Wahl
Rebecca
R
Bowers
Malcolm
M
D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D002395:Catecholamines / Q000097:blood*; D015897:Comorbidity; D005260:Female; D006719:Homovanillic Acid / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D011605:Psychoses, Substance-Induced / Q000097:blood* / Q000175:diagnosis; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
D000928:Antidepressive Agents; D002395:Catecholamines; D006719:Homovanillic Acid; D017367:Selective Serotonin Reuptake Inhibitors