[A linkage disequilibrium study of methylenetetrahydrofolate reductase C677T and schizophrenia].
OBJECTIVE
To explore the relationship between the methylenetetrahy drofolate reductase (MTHFR) C677T missense mutation and schizophrenia by linkage disequilibrium study.


METHODS
Linkage disequilibrium analys is was conducted bet ween MTHFR C677T and schizophrenia in 115 affected-sib-pair (105) and trios (10) families by XDT and MAPMAKER/SIBS soft system. The analyses were performed in different diagnostic categories and combined with the age of onset as well.


RESULTS
No positive results were found in the analysis in all the family in all the four diagnostic categories. Significant P values, which were P<0.05, P<0.01 respectively, were observed in the families with the affected individual's onset age less than 25 years in all the four diagnostic categories.


CONCLUSIONS
The missense mutation of MTHFR C677T or other gene structure around this mutation may be one of the susceptibility gene of schizophrenia.
Deng
Hong
H
Institute of Mental Health, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. rhdeng88@hotmail.com
Liu
Xiehe
X
Cai
Guiqing
G
Sun
Xueli
X
Wang
Yingcheng
Y
Terwedow
Henry
H
Wang
Zhaoxi
Z
Xu
Xin
X
D004247:DNA / Q000235:genetics; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D020125:Mutation, Missense; D009679:Nuclear Family; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D004247:DNA; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)