In vitro antimycobacterial and antilegionella activity of licochalcone A from Chinese licorice roots.
Licochalcone A, extracted and purified from Chinese licorice roots, showed in vitro inhibitory effect on human pathogenic Mycobacteria species and Legionella species. M. tuberculosis, M. bovis and BCG were inhibited by < 20 mg/l licochalcone A, whereas all non- M. tuberculosis complex species were resistant to > 20 mg/l Legionella pneumophila (serogroups 1 - 7) and L. bozemanii, L. dumoffii, L. feelei, L. longbeacheae and L. wadsworthii were inhibited by licochalcone A 1 - 4 mg/l, whereas L. gormanii and L. micdadei were inhibited by licochalcone A 500 - 1000 mg/l. These data indicate that licochalcone A might be of interest as a new class of antibacterial drug in the treatment of severe lung-infections.
Friis-Møller
Alice
A
Department of Clinical Microbiology, Hvidovre Hospital, Copenhagen, Denmark. alice.friis-moeller@hh.hosp.dk
Chen
Ming
M
Fuursted
Kurt
K
Christensen
Søren Brøgger
SB
Kharazmi
Arsalan
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047188:Chalcones; D004365:Drugs, Chinese Herbal; D006035:Glycyrrhiza; D007875:Legionella / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009159:Mycobacteriaceae / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D012293:Rifampin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D047188:Chalcones; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D002599:Chalcone; C070840:licochalcone A; D012293:Rifampin