Enteric nerves and diarrhoea.
This review article discusses the importance of the enteric nervous system for the fluid and electrolyte secretion evoked by luminal secretagogues in the small intestine. The first part of the review summarizes observations on augmented secretion caused by cholera toxin, which has been the subject of extensive studies in the past. The latter part reviews studies of the participation of the enteric nervous system in other secretory states of the gut. The involvement of the enteric nervous system in the pathophysiology of intestinal secretory states opens up potential new sites of actions for drugs in the treatment of diarrhoea. This is discussed in the final part of this review.
Lundgren
Ove
O
Department of Physiology, Sahlgrenska Academy, Göteborg University, Sweden. ove.lundgren@fysiologi.gu.se
D000930:Antidiarrheals / Q000627:therapeutic use; D002772:Cholera Toxin / Q000494:pharmacology; D003967:Diarrhea / Q000188:drug therapy / Q000503:physiopathology*; D004573:Electrolytes / Q000378:metabolism; D004594:Electrophysiology; D017615:Enteric Nervous System / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D012018:Reflex / Q000187:drug effects
D000930:Antidiarrheals; D004573:Electrolytes; D002772:Cholera Toxin