title: First total synthesis of A(2) isoprostane.
abstract: A stereoselective Julia-Lythgoe olefination has allowed the first total synthesis of A(2) isoprostane (1), a recently discovered member of the growing isoprostane family. This elusive compound opens up numerous new avenues for the molecular biology of cyclopentenone prostaglandins, which are endowed of intriguing biological effects such as antitumor, antiinflammatory, and antiviral activities.
authors.affiliation: Department of Organic Chemistry, University of Pavia, Viale Taramelli, 10, 27100, Italy. gzanoni@unipv.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Zanoni
authors.forename: Alessio
authors.initials: A
authors.lastname: Porta
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vidari
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D028421:Isoprostanes / Q000138:chemical synthesis* / Q000145:classification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure
chemical_list: C466067:A(2) isoprostane; D000475:Alkenes; D028421:Isoprostanes