[Fever and skin hemorrhages in children--is it meningococcal disease?].
BACKGROUND
Our main aims were to establish criteria for early distinction between meningococcal disease and other conditions with similar clinical features, and to identify other causes of haemorrhagic rashes accompanied by fever.


METHODS
This prospective study comprised 264 infants and children hospitalised with fever and skin haemorrhages.


RESULTS
We identified an aetiological agent in 28%: 15% had meningococcal disease, 2% another invasive bacterial infection, 7% enterovirus infection, and 4% adenovirus infection. Five clinical variables discriminated meningococcal disease from other conditions on admission: skin haemorrhages of (1) characteristic appearance; (2) universal distribution and (3) a maximum diameter of > 2 mm; (4) poor general condition; and (5) nuchal rigidity.


CONCLUSIONS
If any two or more of these clinical variables were present, the probability of identifying a patient with meningococcal disease was 97% and the false-positive rate was only 12%. This diagnostic algorithm did not identify children in whom septicaemia was caused by other bacterial species.
Nielsen
Hans Erik
HE
Amtssygehuset i Gentofte, DK-2900 Hellerup.
Andersen
Erik Arthur
EA
Andersen
Jesper
J
Böttiger
Blenda
B
Christiansen
Karsten Maidahl
KM
Daugbjerg
Peder Stjernholm
PS
Larsen
Severin Olesen
SO
Lind
Inga
I
Nir
Marta
M
Olofsson
Kern
K
D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005334:Fever / Q000175:diagnosis* / Q000382:microbiology / Q000821:virology; D006470:Hemorrhage / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007223:Infant; D016920:Meningitis, Bacterial / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D008587:Meningitis, Viral / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D008589:Meningococcal Infections / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D008828:Microbiological Techniques; D011446:Prospective Studies; D012867:Skin / Q000473:pathology*; D017192:Skin Diseases, Bacterial / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D017193:Skin Diseases, Viral / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology
Feber og hudblødninger hos børn--er det meningokoksygdom?