title: Dexamethasone inhibition of the cellular immune response of Drosophila melanogaster against a parasitoid.
abstract: Host larvae of Drosophila melanogaster injected with the eicosanoid biosynthesis inhibitor, dexamethasone, prior to parasitization by the wasp Leptopilina boulardi, exhibited significantly reduced rates of melanotic encapsulation in comparison with control and saline-injected larvae. The results of this investigation suggest that prostaglandins and other eicosanoids are involved as cell-signaling molecules in the hemocytic encapsulation reaction of D. melanogaster larvae.
authors.affiliation: Laboratoire Populations, Genetique et Evolution, CNRS, Gif-sur-Yvette, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Carton
authors.forename: Francoise
authors.initials: F
authors.lastname: Frey
authors.forename: David W
authors.initials: DW
authors.lastname: Stanley
authors.forename: Emily
authors.initials: E
authors.lastname: Vass
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Nappi
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000276:immunology / Q000494:pharmacology*; D003907:Dexamethasone / Q000276:immunology / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000187:drug effects / Q000276:immunology* / Q000469:parasitology; D014863:Wasps / Q000276:immunology*
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone