title: Endometrial endometrioid adenocarcinoma in a premenopausal woman presenting with metastasis to bone: a case report and review of the literature.
abstract: We describe the clinicopathologic and immunohistochemical features and microsatellite instability analysis of a rare case of endometrial endometrioid adenocarcinoma presenting as a metastasis to the ischium in a 39-year-old premenopausal woman. The patient was treated with a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic and para-aortic lymphadenectomy. One month later, she underwent an ischial resection followed by radiotherapy. After a follow-up of 3 years, the patient shows no evidence of disease.
authors.affiliation: Department of Pathology, University of Texas Medical School, Houston 77030, USA.
authors.forename: Antonio G
authors.initials: AG
authors.lastname: Neto
authors.forename: Deepali
authors.initials: D
authors.lastname: Gupta
authors.forename: Russell
authors.initials: R
authors.lastname: Broaddus
authors.forename: Anais
authors.initials: A
authors.lastname: Malpica
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D001859:Bone Neoplasms / Q000556:secondary*; D018269:Carcinoma, Endometrioid / Q000235:genetics / Q000473:pathology*; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D016889:Endometrial Neoplasms / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D007512:Ischium / Q000473:pathology*; D018895:Microsatellite Repeats / Q000235:genetics; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009687:Nuclear Proteins; D017697:Premenopause; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; C501486:MLH1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; C497172:MSH2 protein, human; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein