Identification of swainsonine as a glycoside inhibitor responsible for Sida carpinifolia poisoning.
The indolizidine alkaloid swainsonine has been identified as the toxic constituent of Sida carpinifolia, a native perennial shrub-like plant, reported to produce neurological disorders in goats and ponies in southern Brazil. Swainsonine was detected in dry ground plant material after extraction and analysis by both liquid and gas chromatography mass spectrometry. The swainsonine concentration was 0.006% on a dry weight basis. The clinical and pathological features of this lysosomal storage disease were similar to those observed in Swainsona, Oxytropis, Astragalus, and Ipomoea poisonings with multiple cytoplasm vacuoles in neurons, acinar pancreatic cells, hepatocytes, and renal tubular cells.
Colodel
Edson Moleta
EM
Department of Veterinary Pathology, FUFMT, Mato Grosso, Brazil.
Gardner
Dale R
DR
Zlotowski
Priscila
P
Driemeier
David
D
D000818:Animals; D001938:Brazil; D004791:Enzyme Inhibitors / Q000032:analysis* / Q000506:poisoning; D008401:Gas Chromatography-Mass Spectrometry; D006734:Horse Diseases / Q000139:chemically induced; D006736:Horses; D019660:Malvaceae / Q000737:chemistry* / Q000506:poisoning; D010939:Plant Poisoning / Q000209:etiology / Q000662:veterinary; D017026:Swainsonine / Q000032:analysis* / Q000506:poisoning
D004791:Enzyme Inhibitors; D017026:Swainsonine