Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion.
This article represents the proceedings of a symposium at the 2001 Research Society on Alcoholism meeting in Montreal, Canada. The chairs were Alan Cahill and Carol C. Cunningham. The presentations were (1) Mitochondrial regulation of ethanol-induced hepatocyte apoptosis: possible involvement of proapoptotic Bcl-2 family protein Bax, by Masayuki Adachi and Hiromasa Ishii; (2) Effects of ethanol on mitochondrial reactive oxygen species production and oxidative protein modification, by Shannon M. Bailey; (3) Acute ethanol binges elicit widespread oxidative mitochondrial DNA damage and depletion: protective effects of antioxidants and inhibitors of ethanol metabolism, by Bernard Fromenty; and (4) Effects of chronic ethanol consumption upon hepatic mtDNA oxidative modification and depletion, by Alan Cahill and Adrian Davies.
Cahill
Alan
A
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. alan.cahill@mail.tju.edu
Cunningham
Carol C
CC
Adachi
Masayuki
M
Ishii
Hiromasa
H
Bailey
Shannon M
SM
Fromenty
Bernard
B
Davies
Adrian
A
D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000502:physiology; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology
D000431:Ethanol