title: Effects of adsorption of acellular pertussis antigens onto different aluminium salts on the protective activity in an intranasal murine model of Bordetella pertussis infection.
abstract: Adsorption of the pertussis antigens, pertussis toxoid (PT), filamentous hemagglutinin (FHA) and pertactin (PRN) onto aluminium phosphate rather than aluminium hydroxide leads to a lower humoral response and poorer protection against intranasal pertussis challenge in mice. These effects could be reversed by inclusion of fimbriae (FIM) 2 and 3 in the formulation. These data emphasis the importance of correct formulation for such vaccines.
authors.affiliation: Research and Development, GlaxoSmithKline Biologicals, Rue de l'Institut 89, B-1330 Rixensart, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Denoël
authors.forename: J
authors.initials: J
authors.lastname: Poolman
authors.forename: G
authors.initials: G
authors.lastname: Carletti
authors.forename: K
authors.initials: K
authors.lastname: Veitch
mesh_terms: D000281:Administration, Intranasal; D000327:Adsorption; D000535:Aluminum / Q000737:chemistry*; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial / Q000737:chemistry*; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry*; D005260:Female; D006388:Hemagglutinins / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D010567:Pertussis Vaccine / Q000008:administration & dosage* / Q000276:immunology; D014121:Toxoids / Q000737:chemistry*; D010566:Virulence Factors, Bordetella / Q000737:chemistry*; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D006388:Hemagglutinins; D010567:Pertussis Vaccine; D014121:Toxoids; D010566:Virulence Factors, Bordetella; C051093:pertussis toxoid; C068929:pertactin; D000535:Aluminum