Derivative spectrophotometric determination of droperidol in presence of parabens.
We have developed a fast and accurate method for the determination of droperidol in the presence of methylparaben and propylparaben using derivative spectrophotometry. The first derivative amplitudes at 255.2 nm were selected for the assay. Calibration graph follows Beer's law in the range of 5-35 microg ml(-1). The coefficient of variation (CV) for intra-day and inter-day precision were less than 1.0 and 2.0%, respectively. The method was applied in the quality control of commercial oral and injection solutions and proved to be suitable for routine analysis.
Trabelsi
H
H
Laboratoire National de contrôle des Médicaments, 11 bis, rue Djebel Lakhdar, Bab Saadoun 1006, Tunis, Tunisia. trhassen@rns.tn
Raouafi
F
F
Limam
M
M
Bouzouita
K
K
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D018492:Dopamine Antagonists / Q000032:analysis*; D004329:Droperidol / Q000032:analysis*; D004347:Drug Interactions; D010226:Parabens; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011310:Preservatives, Pharmaceutical; D013053:Spectrophotometry / Q000379:methods*
D018492:Dopamine Antagonists; D010226:Parabens; D004364:Pharmaceutical Preparations; D011310:Preservatives, Pharmaceutical; D004329:Droperidol