In vitro activities of new quinolones against Brucella melitensis isolated in a tertiary-care hospital in Turkey.
We have evaluated the in vitro activities of seven fluoroquinolones against 69 strains of Brucella melitensis. According to their minimum inhibitory concentration for 90% growth (MIC(90)) values, the most active agent was found to be sparfloxacin (MIC(90) 0.12 mg/L) followed by levofloxacin, ciprofloxacin, ofloxacin (MIC(90) 0.50 mg/L) and grepafloxacin (MIC(90) 1 mg/L), gemifloxacin (MIC(90) 2 mg/L) and gatifloxacin (MIC(90) 4 mg/L).
Kocagöz
S
S
Department of Medicine and Section of Infectious Diseases, Hacettepe University School of Medicine, Ankara, Turkey.
Akova
M
M
Altun
B
B
Gür
D
D
Hasçelik
G
G
D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017347:Brucella melitensis / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology; D002006:Brucellosis / Q000188:drug therapy; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones; D006761:Hospitals; D006801:Humans; D008826:Microbial Sensitivity Tests; D014421:Turkey
D000890:Anti-Infective Agents; D024841:Fluoroquinolones