title: Platelet antiaggregatory effects and haemodynamic activity of two terfuroxan isomer pairs.
abstract: A couple of terfuroxan isomer pairs 1a,b and 2a,b were studied for their in vivo vasodilating activity and in vitro antiplatelet action. The haemodynamic profiles of the products resemble that of other NO-donors. Their in vitro antiaggregating activity is influenced both by terfuroxan system and by the substituents.
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Turin, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Cena
authors.forename: Sonja
authors.initials: S
authors.lastname: Visentin
authors.forename: Annalisa
authors.initials: A
authors.lastname: Gasco
authors.forename: Piero Antonio
authors.initials: PA
authors.lastname: Martorana
authors.forename: Roberta
authors.initials: R
authors.lastname: Fruttero
authors.forename: Alberto
authors.initials: A
authors.lastname: Gasco
mesh_terms: D000818:Animals; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007536:Isomerism; D008297:Male; D020030:Nitric Oxide Donors / Q000737:chemistry / Q000494:pharmacology; D010069:Oxadiazoles / Q000737:chemistry* / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D013552:Swine; D013997:Time Factors
chemical_list: D020030:Nitric Oxide Donors; D010069:Oxadiazoles; D010975:Platelet Aggregation Inhibitors; C010166:furoxans