Thrombotic microangiopathies.
The thrombotic microangiopathies (TMA) are a group of diseases associated with microangiopathic hemolytic anemia, thrombocytopenia, and end-organ dysfunction. These seemingly disparate entities share in common a pathogenic mechanism involving endothelial injury and thrombus formation. Prognosis and treatment depend on the nature of the underlying disease.
Halevy
Daniel
D
Division of Nephrology, Department of Medicine, Columbia-Presbyterian Medical Center, New York, NY, USA.
Radhakrishnan
Jai
J
Markowitz
Glen
G
Appel
Gerald
G
D000743:Anemia, Hemolytic / Q000150:complications / Q000209:etiology / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000473:pathology; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology; D008833:Microcirculation; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology; D012595:Scleroderma, Systemic / Q000209:etiology; D013921:Thrombocytopenia / Q000150:complications / Q000209:etiology / Q000503:physiopathology; D013927:Thrombosis / Q000150:complications / Q000209:etiology / Q000503:physiopathology