Language-impaired children: No sign of the FOXP2 mutation.
A mutation in the FOXP2 gene has been found to be responsible for the autosomal dominant inheritance of a severe form of speech and language impairment in a family known as KE. We genotyped the FOXP2 mutation for 270 4-year-old children selected for low general language scores from a representative community sample of more than 18,000 children. No language-impaired child had the FOXP2 mutation. Although rare severe disorders such as those of the KE family are often caused by a single gene, common disorders such as language impairment are more likely to be the quantitative extreme of the same multiple genetic factors responsible for heritability throughout the distribution.
Meaburn
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Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, 111 Denmark Hill, London SE5 8AF, UK.
Dale
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PS
Craig
I W
IW
Plomin
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R
D002675:Child, Preschool; D004252:DNA Mutational Analysis; D005091:Exons / Q000235:genetics; D005260:Female; D051858:Forkhead Transcription Factors; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007805:Language Development Disorders / Q000235:genetics*; D008297:Male; D009154:Mutation / Q000235:genetics*; D017354:Point Mutation / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics*; D014157:Transcription Factors
C465448:FOXP2 protein, human; D051858:Forkhead Transcription Factors; D012097:Repressor Proteins; D014157:Transcription Factors