[Influence of angiotensin II type 1 receptor gene polymorphism on patients with essential hypertension complicated by brain infarction].
OBJECTIVE
To identify the A1166/C polymorphism of angiotensin II type 1 receptor (AT1R) gene in patients with essential hypertension complicated with brain infarction (BI).


METHODS
AT1R genotyping with polymerase chain reaction-restrictive fragment length polymorphism was performed in 70 normotensive subjects, 72 hypertensive patients without cardio-cerebrovascular diseases(EH-NCCVD) and 70 hypertensive patients with BI. The relationship between the polymorphism of AT1R gene and plasma lipid levels was also studied.


RESULTS
The frequencies of C allele in the two groups of hypertension were higher than that in the health controls, respectively (P<0.05). But there was no significant difference in the frequency of C allele between the two groups of hypertension. A positive correlation was observed between the lipoprotein(a) and AT1R gene A1166/C polymorphism in hypertensive patients.


CONCLUSIONS
AT1R gene contributes to the development of essential hypertensive, but not to the incidence of BI in the hypertensive.
Zhong
Ya
Y
Gerontology Laboratory, Zhongnan Hospital  Wuhan University  Wuhan  Hubei, 430071 P. R. China.
Ha
Daiwen
D
D000368:Aged; D000483:Alleles; D020520:Brain Infarction / Q000150:complications*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000235:genetics*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin / Q000235:genetics*
D008055:Lipids; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin