title: [Multiple keratoacanthoma centrifugum marginatum].
abstract: BACKGROUND
  Keratoacanthoma centrifugum marginatum is a rare variety of commonly isolated keratoacanthoma. The size of the lesions and prolonged evolution often raise therapeutic problems.
  
  
  METHODS
  A 63-year-old man presented with multiple keratoacanthoma centrifugum marginatum evolving for 6 months and predominating on the lower limbs. Because of the multiplicity and size of the lesions, the patient was treated at acitretine at the dose of 1 mg/kg/day for five months, leading to the regression of all the lesions.
  
  
  CONCLUSIONS
  Keratoacanthoma centrifugum marginatum has rarely been reported in the literature. Our observation remains exceptional in the multiplicity and size of the lesions. The efficacy of retinoids, previously reported in the treatment of solitary giant keratoacanthoma, multiple keratoacanthoma and keratoacanthoma centrifugum marginatum, was demonstrated even in this handicapping form of keratoacanthoma.
authors.affiliation: Service de Dermatologie, EPS La Rabta, 1007 Tunis Jabbari, Tunisie, France.
authors.forename: F
authors.initials: F
authors.lastname: Cherif
authors.forename: A
authors.initials: A
authors.lastname: Mebazaa
authors.forename: R
authors.initials: R
authors.lastname: Kort
authors.forename: N
authors.initials: N
authors.lastname: Makni
authors.forename: S
authors.initials: S
authors.lastname: Haouet
authors.forename: M
authors.initials: M
authors.lastname: Mokni
authors.forename: A
authors.initials: A
authors.lastname: Ben Osman Dhahri
mesh_terms: D006801:Humans; D007636:Keratoacanthoma / Q000473:pathology*; D007868:Leg Dermatoses / Q000473:pathology*; D008297:Male; D008875:Middle Aged
vernacular_title: Kératoacanthomes centrifuges marginés multiples.