Effect of chronic treatment with the protein kinase C inhibitor staurosporine on the acquisition and expression of contextual fear conditioning.
The present study investigated the effects of acute and chronic administration of the protein kinase C inhibitor, staurosporine, on the acquisition and expression of conditioned freezing behavior, an index of anxiety induced by conditioned fear stress. Results revealed that acute staurosporine (0.01 and 0.1 mg/kg, i.p.) did not affect either acquisition or expression of conditioned freezing. Chronic staurosporine administration (0.01 or 0.1 mg/kg, i.p., for 14 days) significantly reduced the acquisition of conditioned freezing at a dose of 0.1 mg/kg, but failed to affect the expression of conditioned freezing at any dose. These results suggest the involvement of protein kinase C in synaptic and cellular plasticity underlying emotional learning and memory.
Li
Xiao Bai
XB
Department of Psychiatry, Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita, Sapporo 060-8638, Japan. xiao@med.hokudai.ac.jp
Inoue
Takeshi
T
Koyama
Tsukasa
T
D000818:Animals; D002352:Carrier Proteins / Q000008:administration & dosage*; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005239:Fear / Q000187:drug effects* / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D010147:Pain Measurement / Q000187:drug effects; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D019311:Staurosporine / Q000008:administration & dosage*
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C015482:protein kinase modulator; D011493:Protein Kinase C; D019311:Staurosporine