title: Clinical efficacy and pharmacokinetics of carprofen in the treatment of dogs with osteoarthritis.
abstract: Six medium to large breed dogs with osteoarthritis were treated with 2 mg/kg of racemic carprofen, mixed with their morning feed, daily for 28 days. The treatment significantly (P < 0.01) reduced their mean lameness score, measured on a visual analogue scale, and there was a trend (P = 0.11) for the peak vertical forces exerted on a forceplate to be increased in the most severely affected limb. The plasma concentration-time relationships of the S(+) and R(-) enantiomers were studied for 24 hours after the first dose and after seven days and 28 days. There were no significant differences between the mean pharmacokinetic parameters measured on the three occasions, suggesting that carprofen was not accumulated and that tolerance to the drug did not develop. Although the pharmacokinetic parameters of the S(+) and R(-) enantiomers were generally very similar, there were wide variations both between and within dogs.
authors.affiliation: Department of Small Animal Medicine and Surgery, The Royal Veterinary College, University of London, Hatfield, Herts.
authors.forename: V J
authors.initials: VJ
authors.lastname: Lipscomb
authors.forename: F S
authors.initials: FS
authors.lastname: AliAbadi
authors.forename: P
authors.initials: P
authors.lastname: Lees
authors.forename: M J
authors.initials: MJ
authors.lastname: Pead
authors.forename: P
authors.initials: P
authors.lastname: Muir
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D019540:Area Under Curve; D001947:Breeding; D002227:Carbazoles / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs / Q000378:metabolism*; D007536:Isomerism; D007794:Lameness, Animal / Q000188:drug therapy; D010003:Osteoarthritis / Q000188:drug therapy / Q000662:veterinary*; D010146:Pain / Q000188:drug therapy / Q000662:veterinary; D010147:Pain Measurement / Q000662:veterinary; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; C007005:carprofen