title: Evaluation of liquid-based cytology in cervical screening of high-risk populations: a split study of colposcopy and genito-urinary medicine populations.
abstract: A split study evaluated the ThinPrep(R) PapTesttrade mark (TP; Cytyc Corp., Boxborough, MA) compared with current methodologies of cervical cytology in two high-risk cohorts. One thousand, three hundred cases from a colposcopy clinic and a genito-urinary medicine outpatient clinic were examined. The TP reported increased detection of all grades of dyskaryosis (mild, moderate and severe; + 4.5%) and a decrease in borderline and unsuitable cases (- 4.9%). Four cases of high-grade dyskaryosis (moderate or severe) were detected only using the TP, while an additional four cases classified as high-grade dyskaryosis with the TP were reported as borderline by our conventional methods. The split-study finding of increased sensitivity with the TP provides for improved clinical management of patients in our high-risk cohorts.
authors.affiliation: Department of Cytology, Coombe Women's Hospital, Dublin, Ireland. mring@coombe.ie
authors.forename: M
authors.initials: M
authors.lastname: Ring
authors.forename: N
authors.initials: N
authors.lastname: Bolger
authors.forename: M
authors.initials: M
authors.lastname: O'Donnell
authors.forename: A
authors.initials: A
authors.lastname: Malkin
authors.forename: N
authors.initials: N
authors.lastname: Bermingham
authors.forename: E
authors.initials: E
authors.lastname: Akpan
authors.forename: F
authors.initials: F
authors.lastname: Mulcahy
authors.forename: M J
authors.initials: MJ
authors.lastname: Turner
authors.forename: M
authors.initials: M
authors.lastname: Griffin
authors.forename: J J
authors.initials: JJ
authors.lastname: O'Leary
mesh_terms: D002467:Cell Nucleus / Q000473:pathology; D015331:Cohort Studies; D003127:Colposcopy; D005260:Female; D016591:Histocytological Preparation Techniques; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008403:Mass Screening / Q000379:methods*; D010044:Outpatient Clinics, Hospital; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D014626:Vaginal Smears / Q000379:methods*