title: Crystallization at the polymer/calcium-phosphate interface in a sterilized injectable bone substitute IBS.
abstract: Calcium phosphate (CaP) ceramics are the main raw materials used to elaborate blocks or granules for bone substitutes. In this study, injectable bone substitutes (IBS) were developed for applications in orthopedic or dental surgery. Sterile, ready-to-use composite containing CaP granules (biphasic calcium phosphate, BCP) and polymer (hydroxypropylmethylcellulose, HPMC) was prepared. Steam sterilization produced new phenomena at the CaP/polymer interface, resulting in crystal growth. These phenomena may constitute a model for the biomineralization study. Scanning electron microscopy showed that the formed crystallites organize themselves into a three-dimensional structure. Currently, the mechanisms of crystal growth are unknown and have been observed with only one combination of polymer/BCP ceramics after steam sterilization.
authors.affiliation: INSERM Research Center on Materials of Biological Interest, UFR de Odontologie, Dental Faculty, Nantes, France.
authors.forename: M
authors.initials: M
authors.lastname: Schmitt
authors.forename: P
authors.initials: P
authors.lastname: Weiss
authors.forename: X
authors.initials: X
authors.lastname: Bourges
authors.forename: G
authors.initials: G
authors.lastname: Amador del Valle
authors.forename: G
authors.initials: G
authors.lastname: Daculsi
mesh_terms: D001672:Biocompatible Materials / Q000494:pharmacology; D018786:Bone Substitutes / Q000008:administration & dosage / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000737:chemistry* / Q000494:pharmacology; D003460:Crystallization; D006863:Hydrogen-Ion Concentration; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D011108:Polymers; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous