Spectroelectrochemical study of the interaction between antitumor drug daunomycin and DNA in the presence of antioxidants.
Anthracycline drug daunomycin (DNR) is a widely used clinical drug. But its side effects, especially cardiotoxicity, have greatly restrained its application. The side effects were due to free radical formation in the metabolic process of DNR. The purpose of this study is to diminish the side effects by using antioxidants. Two kinds of free radical scavengers have been investigated, that is, vitamins: vitamin C (V(C)), rutin (V(P)) and vitamin B6 (V(B6)); amino acids: cysteine (CysH) and methionine (Met). Free radical scavenging efficiency (E degrees (eff)) of these antioxidants had been calculated. Under the experimental condition, the values of E degrees (eff) of V(C), V(P), V(B6), CysH and Met were 23.8, 15.3, 6.4, 48.2 and -7.7%, respectively. The relationship between the free radical scavenging activities and its chemical structure has also been discussed.
Cheng
Guifang
G
Department of Chemistry, East China Normal University, ZhongShan Road North 3663, Shanghai 200 062, People's Republic of China.
Qu
Haiyun
H
Zhang
Dongmei
D
Zhang
Jidong
J
He
Pinggang
P
Fang
Yuzhi
Y
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004249:DNA Damage; D003630:Daunorubicin / Q000737:chemistry*; D004347:Drug Interactions; D004563:Electrochemistry
D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D003630:Daunorubicin