Effects of withdrawal from anabolic androgenic steroids on aggression in adult male rats.
In gonadally intact male rats, chronic exposure to high levels of testosterone propionate (TP) increases aggression, nandrolone (ND) has little effect and stanozolol (ST) suppresses aggression. The present experiment tested whether the effects of TP, ND and ST on aggression and reproductive tissues are reversed following anabolic androgenic steroid (AAS) withdrawal. Gonadally intact males received TP, ND, ST or vehicle for 12 weeks. Injections were then discontinued. Aggression was tested 3 weeks (short term) and 12 weeks (long term) after withdrawal of AAS treatment, with either a gonadally intact or a castrated opponent in three different environments (home, opponent's and neutral cage). After short-term withdrawal, some parameters of aggression were significantly above control levels in TP males. There were no significant differences between ND or ST males and controls, though ST males showed the lowest levels of aggression. No significant differences between any of the groups were found after long-term withdrawal. Eighteen weeks after AAS withdrawal, serum testosterone (T) and LH levels were comparable to controls in all groups. Testes weights were at control levels in ST males, but significantly higher than controls in TP and ND males. Seminal vesicle weights were significantly elevated in TP males, but similar to controls in both ND and ST males. None of the prostate weights were significantly different from controls. These results suggest that aggression gradually returns to normal following withdrawal from AAS. Some, if not all, hormone levels and tissue weights return to normal, suggesting possible long-lasting effects of chronic AAS exposure.
McGinnis
Marilyn Y
MY
Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029, USA. marilyn.mcginnis@mssm.edu
Lumia
Augustus R
AR
Possidente
Bernard P
BP
D000374:Aggression / Q000187:drug effects / Q000502:physiology*; D045930:Anabolic Agents / Q000009:adverse effects*; D000728:Androgens / Q000009:adverse effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005837:Genitalia, Male / Q000187:drug effects; D008297:Male; D009277:Nandrolone / Q000009:adverse effects; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans; D012930:Social Dominance; D013197:Stanozolol / Q000009:adverse effects; D013375:Substance Withdrawal Syndrome / Q000523:psychology*; D013739:Testosterone / Q000009:adverse effects / Q000097:blood
D045930:Anabolic Agents; D000728:Androgens; D013739:Testosterone; D013197:Stanozolol; D009277:Nandrolone