Looking over the edge: a new role for Ena/VASP proteins in lamellipodial dynamics.
How can Ena/VASP proteins promote actin-based movement of the intracellular pathogen Listeria or rapid protrusion of lamellipodia but at the same time inhibit cell translocation? A report in the May 17(th) issue of Cell now offers a possible explanation for this conundrum. Bear et al. report that Ena/VASP proteins regulate cell motility by competing with capping proteins to control actin filament length and geometry at the leading edge of cells.
Sutherland
James D
JD
Cell Motility Laboratory, Cancer Research UK.
Way
Michael
M
D051339:Actin Depolymerizing Factors; D000199:Actins / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002465:Cell Movement; D015638:Cytochalasin D / Q000494:pharmacology; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins / Q000502:physiology*; D051345:Destrin; D008087:Listeria; D008387:Marine Toxins / Q000494:pharmacology; D008840:Microfilament Proteins / Q000502:physiology; D009154:Mutation; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D010750:Phosphoproteins / Q000502:physiology*; D011554:Pseudopodia / Q000502:physiology*; D013844:Thiazoles / Q000494:pharmacology; D053778:Thiazolidines; D000098662:Vasodilator-Stimulated Phosphoprotein
D051339:Actin Depolymerizing Factors; D000199:Actins; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D051345:Destrin; C092744:ENA-VASP proteins; C102176:Enah protein, mouse; D008387:Marine Toxins; D008840:Microfilament Proteins; D019384:Nucleic Acid Synthesis Inhibitors; D010750:Phosphoproteins; D013844:Thiazoles; D053778:Thiazolidines; D000098662:Vasodilator-Stimulated Phosphoprotein; D015638:Cytochalasin D; C037068:latrunculin B