title: Monocyte chemotactic protein-1 levels in the vitreous of patients with proliferative vitreoretinopathy.
abstract: OBJECTIVE
  To assess the potential role of monocyte chemotactic protein-1 (MCP-1) in the pathogenesis of proliferative vitreoretinopathy (PVR) and to investigate its possible interaction with the macrophage migration inhibitory factor (MIF).
  
  
  METHODS
  We assayed MCP-1 and MIF levels in the vitreous samples of 85 consecutive patients with PVR (29 eyes), rhegmatogenous retinal detachment (RRD; 22 eyes), and macular hole or idiopathic epimacular membrane (controls; 34 eyes), by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Vitreous levels of MCP-1 were 1760.7 +/- 471.3 pg/mL (mean +/- SD) in PVR patients, 1200.4 +/- 579.8 pg/mL in RRD patients, and 436.3 +/- 286.1 pg/mL in the controls. Vitreous MCP-1 levels in PVR patients were significantly higher than those in RRD patients and in the controls (P <.0001, respectively). MCP-1 levels in grade C of PVR (1883.7 +/- 479.5 pg/mL) were significantly greater than those in grade D (1437.8 +/- 258.8 pg/mL) (P =.0112). Vitreous concentrations of MCP-1 had no correlation with those of MIF.
  
  
  CONCLUSIONS
  The results indicate the possibility that MCP-1 may have a role mainly in the early stage of PVR and that the role of MCP-1 in PVR may differ from that of MIF.
authors.affiliation: Department of Ophthalmology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Mitamura
authors.forename: Shinobu
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Teiko
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Itsuro
authors.initials: I
authors.lastname: Tsukahara
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuda
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Tagawa
authors.forename: Yuka
authors.initials: Y
authors.lastname: Mizue
authors.forename: Jun
authors.initials: J
authors.lastname: Nishihira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018932:Chemokine CCL2 / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D019773:Epiretinal Membrane / Q000378:metabolism; D005260:Female; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000378:metabolism; D012167:Retinal Perforations / Q000378:metabolism; D018630:Vitreoretinopathy, Proliferative / Q000378:metabolism*; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D018932:Chemokine CCL2; D008263:Macrophage Migration-Inhibitory Factors