title: O-Benzyl-N-tert-butoxycarbonyl-N-methyl-L-tyrosine.
abstract: The crystal structure of the title compound, alternatively called 3-[4-(benzyloxy)phenyl]-2-(N-tert-butoxycarbonyl-N-methylamino)propionic acid, C(22)H(27)NO(5), has been studied in order to examine the role of N-methylation as a determinant of peptide conformation. The conformation of the tert-butoxycarbonyl group is trans-trans. The side chain has a folded conformation and the two phenyl rings are effectively perpendicular to one another. The carboxylate hydroxyl group and the urethane carbonyl group form a strong intermolecular O[bond]H...O hydrogen bond.
authors.affiliation: Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Jankowska
authors.forename: Mirosław
authors.initials: M
authors.lastname: Gilski
authors.forename: Mariusz
authors.initials: M
authors.lastname: Jaskólski
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Grzonka
authors.forename: Leszek
authors.initials: L
authors.lastname: Łankiewicz