title: [Familial pancreatic cancer--concept for study of the National Case Collection and early diagnosis program for high risk people].
abstract: Ductal pancreatic cancer is a public health problem on the increase. The lethality and incidence of this disease are almost identical. A number of these cancers cluster in families. By definition, pancreatic cancer appearing in at least two first degree relatives is named familial pancreatic cancer (FPC). The "National Case Collection Familial Pancreatic Cancer" (FaPaCa) was founded at the Philipps University of Marburg, Germany, in July 1999 within the scope of the project "Clinical and genetic examinations of familial exocrine pancreatic cancer including the foundation of a national case collection" (http://www.med.uni-marburg.de/fapaca). The aims of this project are 1 to evaluate the share of FPC of all pancreatic cancers by performing a multi-centered study, 2 to identify epidemiological risk factors that predispose to pancreatic cancer in these families, 3 to identify families with a likely genetic predisposition to pancreatic cancer, 4 to offer a screening program for high risk individuals in these families, which is to be evaluated in an observational study, and finally to identify presumed genetic defects that predispose to pancreatic cancer in FPC families. This manuscript presents the scientific concept behind the FaPaCa project and reports on its attendant screening program for FPC families.
authors.affiliation: Klinik für Viszeral-, Thorax- und Gefässchirurgie, Philipps Universität Marburg.
authors.forename: Berthold
authors.initials: B
authors.lastname: Gerdes
authors.forename: Ralf
authors.initials: R
authors.lastname: Kress
authors.forename: Harald
authors.initials: H
authors.lastname: Rieder
authors.forename: Mercedes
authors.initials: M
authors.lastname: Sina-Frey
authors.forename: Elvira
authors.initials: E
authors.lastname: Przypadlo
authors.forename: Peter
authors.initials: P
authors.lastname: Barth
authors.forename: Helga
authors.initials: H
authors.lastname: Rehder
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Hahn
authors.forename: Wolff
authors.initials: W
authors.lastname: Schmiegel
authors.forename: Matthias
authors.initials: M
authors.lastname: Rothmund
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.forename: Detlef K
authors.initials: DK
authors.lastname: Bartsch
mesh_terms: D005858:Germany; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D017410:Practice Guidelines as Topic; D011785:Quality Assurance, Health Care; D012042:Registries; D012307:Risk Factors
vernacular_title: Familiäres Pankreaskarzinom--Studienkonzept einer Nationalen Fallsammlung mit Früherkennungsprogramm für Hochrisikopersonen.