title: Effects of Yoku-kan-san-ka-chimpi-hange on the sleep of normal healthy adult subjects.
abstract: Yoku-kan-san-ka-chimpi-hange (YKCH) is a drug used for insomnia in Japanese traditional herbal medicine. The present study evaluated the effects of YKCH on sleep by all-night polysomnography using the double-blind method. Yoku-kan-san-ka-chimpi-hange increased the total sleep time significantly, and tended to cause an increase in sleep efficiency and of stage 2 sleep, as well as a decrease of sleep latency and of stage 3 + 4 sleep. There was no apparent influence on rapid eye movement (REM) sleep. In terms of non-REM sleep, the effects of YKCH exhibit a profile similar to those of benzodiazepines.
authors.affiliation: Japanese Red Cross Junior College of Akita, Akita city, Japan. aizawa@venus.rcakita-jc.ac.jp
authors.forename: Rika
authors.initials: R
authors.lastname: Aizawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanbayashi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Saito
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Tomonari
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kitajima
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Masahito
authors.initials: M
authors.lastname: Abe
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000328:Adult; D001569:Benzodiazepines / Q000008:administration & dosage; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal; D006801:Humans; D008297:Male; D008518:Medicine, East Asian Traditional; D017286:Polysomnography / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects; D012894:Sleep Stages / Q000187:drug effects*
chemical_list: D004365:Drugs, Chinese Herbal; C000607904:yokukansankachimpihange; D001569:Benzodiazepines