Immunolocalization of urokinase and its receptor in prematurely fused cranial sutures of infants.
In cranial sutural samples derived from five children with premature cranial suture fusion we have performed immunostaining for the urokinase plasminogen activator (uPA) and urokinase receptor (uPAR). We have found a strong reactivity for cell- or matrix-bound uPA and uPAR in the sutural connective tissue and associated with the osteoblasts and osteocytes lining the calvarial bone. The sutural tissue itself showed a banding with different intensity of urokinase and uPAR staining concerning connective tissue. It is proposed that the components of the plasminogen activating system are involved in tissue turnover of sutural tissue and in sutural growth.
Zeitler
P
P
Department of Pediatrics, University of Würzburg, Germany. zeitler@mail.uni-wuerzburg.de
Pahnke
J
J
Collmann
H
H
D003238:Connective Tissue / Q000201:enzymology; D003393:Cranial Sutures / Q000201:enzymology*; D003398:Craniosynostoses / Q000201:enzymology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D015675:Osteocalcin / Q000032:analysis; D010960:Plasminogen Activators / Q000032:analysis / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000032:analysis / Q000378:metabolism*; D055293:Receptors, Urokinase Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis / Q000378:metabolism*
C524898:PLAUR protein, human; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator; D015675:Osteocalcin; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator