title: In vivo application of non-viral vectors to the liver.
abstract: The liver plays a central role in many inherited and acquired genetic disorders, and thus is a potential target for nucleic acid therapies. Despite the great strides made in basic molecular biology over the last two decades successful gene therapy remains elusive. Most recently, there has been considerable effort to develop non-viral gene therapy approaches, in part, to overcome the potential complications associated with viral delivery systems. This review outlines the different non-viral approaches available to the liver, and includes a detailed review of recent advances in delivery vectors for use in techniques such as gene augmentation, with particular emphasis on useful applications of antisense and ribozyme technology.
authors.affiliation: Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Richardso
authors.forename: Betsy T
authors.initials: BT
authors.lastname: Kren
authors.forename: Clifford J
authors.initials: CJ
authors.lastname: Steer
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000008:administration & dosage; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000008:administration & dosage*; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage; D008099:Liver / Q000187:drug effects*; D009696:Nucleic Acids / Q000008:administration & dosage; D011994:Recombinant Proteins / Q000008:administration & dosage
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D009696:Nucleic Acids; D011994:Recombinant Proteins