DNAzymes: cutting a path to a new class of therapeutics.
DNAzymes are synthetic catalytic deoxyribonucleic acid molecules that can be engineered to bind to their complementary sequence in the target nucleic acid through Watson-Crick base pairing and cleave at predetermined phosphodiester linkages. This article reviews the recent use of DNAzymes as probes of molecular function and their potential applications in clinical medicine.
Khachigian
Levon M
LM
Centre for Thrombosis and Vascular Research, Department of Pathology, University of New South Wales, Sydney, Australia. L. Khachigian@unsw.edu.au
D000818:Animals; D015342:DNA Probes; D021881:DNA, Catalytic / Q000378:metabolism* / Q000627:therapeutic use; D005786:Gene Expression Regulation; D006801:Humans
D015342:DNA Probes; D021881:DNA, Catalytic