title: Striking effect of left ventricular high filling pressure with mitral regurgitation on mitral annular velocity during early diastole. A study using colour M-mode tissue Doppler imaging.
abstract: OBJECTIVE
  To evaluate the effect of considerably high left ventricular filling pressure with mitral regurgitation on mitral annular velocity during early diastole.
  
  
  METHODS
  Two hundred and forty-three patients who underwent cardiac catheterization for evaluation of chest pain.
  
  
  METHODS
  Mitral annular velocity during early diastole was measured by colour M-mode tissue Doppler imaging. Patients were divided into the following three groups according to the cardiac catheterization data. Group A (n=147): patients having left ventricular relaxation time constant tau<46 ms and left ventricular end-systolic volume index <38 ml m(-2); group B (n=88): patients having tau>or=46 ms and/or end-systolic volume index >or=38 ml m(-2); group C (n=8): patients having mean pulmonary capillary wedge pressure >or=16 mmHg in addition to tau>or=46 ms and end-systolic volume index >or=38 ml m(-2).
  
  
  RESULTS
  Mitral annular velocity during early diastole was significantly less in group B (4.8+/-1.4 cm s(-1)) than in group A (7.7+/-1.9 cm s(-1)). However, there was no significant difference between groups A and C (8.3+/-0.8 cm s(-1)). A transmitral E/A >1.0 was observed in 12/147 patients of group A, 10/88 of group B, and 8/8 of group C. The incidence of >or=Sellers' grade II mitral regurgitation was higher in group C than the others.
  
  
  CONCLUSIONS
  A paradoxically faster mitral annular velocity during early diastole is found in patients having left ventricular dysfunction with moderate to severe mitral regurgitation and considerably high left ventricular filling pressure. Attention should be paid to an interpretation of mitral annular velocity during early diastole regarding left ventricular early diastolic performance in patients having mitral regurgitation with an E/A >1.0 in their transmitral flow.
authors.affiliation: Third Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan. ohte@med.nagoya-cu.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Ohte
authors.forename: H
authors.initials: H
authors.lastname: Narita
authors.forename: S
authors.initials: S
authors.lastname: Akita
authors.forename: K
authors.initials: K
authors.lastname: Kurokawa
authors.forename: J
authors.initials: J
authors.lastname: Hayano
authors.forename: G
authors.initials: G
authors.lastname: Kimura
mesh_terms: D001783:Blood Flow Velocity; D006328:Cardiac Catheterization; D003971:Diastole; D004452:Echocardiography; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011669:Pulmonary Wedge Pressure; D013318:Stroke Volume; D016277:Ventricular Function, Left; D017725:Ventricular Pressure