title: Growth and decline of introns.
abstract: To gauge the processes that might direct the length of introns, I studied the balance of indels (insertions or deletions, determined using Alu and LINE1 retroposon repeats) and the density of these repeats in the introns of the human genome. The indel balance is biased in favour of deletions and correlated with the divergence of repeats. At fixed repeat divergence, the indel bias correlated with the intron size: the shorter the intron, the more deletions were favoured over insertions. This correlation with the intron size was stronger than with the gene-wide or isochore-wide parameters. The density of repeats (the number of repeats in a unit of intron length) correlated positively with the intron size. Thus, quite different mechanisms, the indel bias and the integration and/or persistence of retroposons, act in the same direction in regards to intron size, which suggests selection for the size of individual introns.
authors.affiliation: Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, St Petersburg 194064, Russia. aevin@mail.cytspb.rssi.ru
authors.forename: Alexander E
authors.initials: AE
authors.lastname: Vinogradov
mesh_terms: D020087:Alu Elements; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D007438:Introns; D020084:Long Interspersed Nucleotide Elements; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004247:DNA