title: Downstream targets of let-60 Ras in Caenorhabditis elegans.
abstract: In Caenorhabditis elegans, let-60 Ras controls many cellular processes, such as differentiation of vulval epithelial cells, function of chemosensory neurons, and meiotic progression in the germ line. Although much is known about the let-60 Ras signaling pathway, relatively little is understood about the target genes induced by let-60 Ras signaling that carry out terminal effector functions leading to morphological change. We have used DNA microarrays to identify 708 genes that change expression in response to activated let-60 Ras.
authors.affiliation: Department of Developmental Biology and Genetics, Stanford University Medical School, California 94305, USA.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Romagnolo
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.forename: Moni
authors.initials: M
authors.lastname: Kiraly
authors.forename: Carrie
authors.initials: C
authors.lastname: Breton
authors.forename: Rebecca
authors.initials: R
authors.lastname: Begley
authors.forename: John
authors.initials: J
authors.lastname: Wang
authors.forename: James
authors.initials: J
authors.lastname: Lund
authors.forename: Stuart K
authors.initials: SK
authors.lastname: Kim
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins; D018507:Gene Expression Regulation, Developmental; D015801:Helminth Proteins / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D015398:Signal Transduction / Q000235:genetics; D018631:ras Proteins / Q000235:genetics*
chemical_list: D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; C066646:let-60 protein, C elegans; D018631:ras Proteins