[Antimicrobial activity of myeloperoxidase from neutrophil peroxisome].
Myeloperoxidase plays the key role in antimicrobial oxygen-dependent activity of neutrophils. This heme-containing enzyme catalyzes HOCl formation from H2O2 and Cl-. HOCl is a strong oxidation agent produced at the significant level by neutrophils. Myeloperoxidase easily oxidizes thiocyanate to hypothiocyanate and Br- to HOBr, which are involved in protective reactions. Myeloperoxidase reacts quickly with nitric oxide and peroxynitrite in inflammation foci. All these reactions affect neutrophil-induced oxidative stress.
But
P G
PG
Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991 Russia.
Murav'ev
R A
RA
Fomina
V A
VA
Rogovin
V V
VV
D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism*; D001965:Bromides / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D009504:Neutrophils / Q000201:enzymology*; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D009195:Peroxidase / Q000737:chemistry / Q000378:metabolism*; D020675:Peroxisomes / Q000378:metabolism*; D030421:Peroxynitrous Acid / Q000378:metabolism; D013861:Thiocyanates / Q000378:metabolism
D000890:Anti-Infective Agents; D001965:Bromides; D002712:Chlorides; D013861:Thiocyanates; D030421:Peroxynitrous Acid; D009569:Nitric Oxide; D006861:Hydrogen Peroxide; D009195:Peroxidase; C031760:thiocyanate
Antimikrobnaia aktivnost' mieloperoksidazy peroksidazosom neĭtrofila.