[Changes in phospholipid components of pulmonary surfactant in experimental influenza infection and their correction by remantadin and deitiforine].
Changes in the levels of total phospholipids and phospholipid fractions of pulmonary surfactant fractions of albino mice intranasally infected with influenza A/Aichi/2/68(H3N2) virus in a dose of 5 LD50 were studied. Reproduction of influenza virus in mice is paralleled by fluctuations in the level of total lipids and changes in the phospholipid components of pulmonary surfactant. Antiviral drugs remantadin and deitiforine injected in accordance with the treatment and prophylaxis protocol to infected animals exerted a protective effect as regards the studied pulmonary surfactant phospholipids.
Kazinets
O N
ON
Amvros'eva
T V
TV
Rusiaev
V A
VA
D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002855:Chromatography, Thin Layer; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D009930:Organic Chemicals; D009975:Orthomyxoviridae; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000378:metabolism; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D011663:Pulmonary Surfactants / Q000737:chemistry / Q000378:metabolism*; D012299:Rimantadine / Q000008:administration & dosage / Q000627:therapeutic use*
D000998:Antiviral Agents; D009930:Organic Chemicals; D010743:Phospholipids; D011663:Pulmonary Surfactants; D012299:Rimantadine; C060204:deitiforin
Izmeneniia fosfolipidnykh komponentov surfaktanta legkikh pri éksperimental'noĭ grippoznoĭ infektsii i ikh korrektsia remantadinom i deĭtiforinom.