title: Mechanical deformation of compressible chromatographic columns.
abstract: A one-dimensional model of mechanical deformation of compressible chromatography columns is presented. The model is based on linear elasticity and continuum mechanics and is compared to a more complete two-dimensional model and one-dimensional porosity profiles measured by NMR imaging methods. The model provides a quantitative description of compression and the effects of wall support during scale-up. A simple criterion for the significance of wall support as a function of both diameter and length is also developed. Although the model accounts only for mechanical deformation, flow compression can be included, and validation presented here suggests that a more complete model may be valuable for anticipating the effects of scale and aspect ratio on pressure-flow behavior of compressible columns.
authors.affiliation: Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904, USA.
authors.forename: R N
authors.initials: RN
authors.lastname: Keener
authors.forename: J E
authors.initials: JE
authors.lastname: Maneval
authors.forename: K C E
authors.initials: KC
authors.lastname: Ostergren
authors.forename: E J
authors.initials: EJ
authors.lastname: Fernandez
mesh_terms: D002853:Chromatography, Liquid / Q000295:instrumentation*; D009682:Magnetic Resonance Spectroscopy; D012680:Sensitivity and Specificity