Effects of orexin on the laterodorsal tegmental neurones.
Orexin, a hypothalamic neuropeptide, has been revealed to be involved in sleep regulation. To elucidate functions of orexin in brainstem sleep regulation mechanism, we examined the effects of orexin applied from micropipettes with air pressure on neurones in and around the laterodorsal tegmental nucleus (LDT). In five of seven cholinergic neurones and six of nine non-cholinergic neurones orexin induced long-lasting excitation. These results suggest that hypothalamic orexin neurones may affect the LDT neurones directly, and thereby participate in control of sleep.
Takahashi
Kazumi
K
Department of Physiology, School of Medicine, Fukushima Medical University, Fukushima, Japan. takahasi@fmu.ac.jp
Koyama
Yoshimasa
Y
Kayama
Yukihiko
Y
Yamamoto
Mitsuaki
M
D000818:Animals; D001933:Brain Stem / Q000502:physiology; D002352:Carrier Proteins / Q000134:cerebrospinal fluid*; D007031:Hypothalamus / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009474:Neurons / Q000502:physiology*; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000502:physiology
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins