title: Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells.
abstract: According to the temporal coding hypothesis, neurons encode information by the exact timing of spikes. An example of temporal coding is the hippocampal phase precession phenomenon, in which the timing of pyramidal cell spikes relative to the theta rhythm shows a unidirectional forward precession during spatial behaviour. Here we show that phase precession occurs in both spatial and non-spatial behaviours. We found that spike phase correlated with instantaneous discharge rate, and processed unidirectionally at high rates, regardless of behaviour. The spatial phase precession phenomenon is therefore a manifestation of a more fundamental principle governing the timing of pyramidal cell discharge. We suggest that intrinsic properties of pyramidal cells have a key role in determining spike times, and that the interplay between the magnitude of dendritic excitation and rhythmic inhibition of the somatic region is responsible for the phase assignment of spikes.
authors.affiliation: Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA.
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Harris
authors.forename: Darrell A
authors.initials: DA
authors.lastname: Henze
authors.forename: Hajime
authors.initials: H
authors.lastname: Hirase
authors.forename: Xavier
authors.initials: X
authors.lastname: Leinekugel
authors.forename: George
authors.initials: G
authors.lastname: Dragoi
authors.forename: Andras
authors.initials: A
authors.lastname: Czurkó
authors.forename: György
authors.initials: G
authors.lastname: Buzsáki
mesh_terms: D000200:Action Potentials; D000704:Analysis of Variance; D000818:Animals; D003198:Computer Simulation; D003712:Dendrites / Q000502:physiology; D007700:Kinetics; D008297:Male; D009043:Motor Activity / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology*; D051381:Rats; D012895:Sleep, REM / Q000502:physiology; D013826:Theta Rhythm