Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors.
Recent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in sleep/wake regulation. In addition, the orexin system may link energy homeostasis to the regulation of sleep/wake cycles.
Mieda
Michihiro
M
Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9050, USA.
Yanagisawa
Masashi
M
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009290:Narcolepsy / Q000235:genetics / Q000378:metabolism; D009479:Neuropeptides / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D064446:Orexin Receptors; D000068797:Orexins; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide / Q000235:genetics / Q000502:physiology*; D012890:Sleep / Q000502:physiology*
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D064446:Orexin Receptors; D000068797:Orexins; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide