Concise synthesis and enzymatic resolution of L-(+)-homophenylalanine hydrochloride.
The N-acetyl-homophenylalanine ethyl ester was synthesized by a simple three-step-reaction strategy. L-(+)-homophenylalanine hydrochloride with 98% ee was obtained through a kinetic resolution process using industrial enzyme alcalase. Compared with other methods, this strategy has the advantage of economical and simple procedure giving high product optical purity.
Zhao
Hua
H
Department of Chemical Engineering, Chemistry and Environmental Science, New Jersey Institute of Technology, University Heights, Newark 07102, USA.
Luo
Robert G
RG
Wei
Dean
D
Malhotra
Sanjay V
SV