title: [Interaction of RNA with phospholipid membranes].
abstract: RNAs binding with liposomes under near physiological conditions were obtained by molecular selection. Structural analysis showed that the RNAs could form complexes owing to complementary sequences located in loops. Oligomerization of the RNAs selected was experimentally confirmed. The results and published data testified that formation of high-molecular-weight complexes is a major mechanism increasing the RNA affinity for phospholipid membranes. The role of RNA-membrane interactions in early evolution is discussed in terms of the RNA world hypothesis.
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, USA. avlassov@somagenics.com
authors.forename: A
authors.initials: A
authors.lastname: Vlasov
authors.forename: M
authors.initials: M
authors.lastname: Yarus
mesh_terms: D001483:Base Sequence; D008081:Liposomes; D008567:Membranes, Artificial; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009690:Nucleic Acid Conformation; D010743:Phospholipids / Q000737:chemistry* / Q000378:metabolism; D012313:RNA / Q000737:chemistry* / Q000378:metabolism
chemical_list: D008081:Liposomes; D008567:Membranes, Artificial; D010743:Phospholipids; D012313:RNA
vernacular_title: Vzaimodeĭstvie RNK s fosfolipidnymi membranami.