title: Linkage of essential hypertension to chromosome 18q.
abstract: We performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P=2.1x 10(-6)). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes.
authors.affiliation: deCODE genetics, Inc, Reykjavik, Iceland. kris@ decode.is
authors.forename: Kristleifur
authors.initials: K
authors.lastname: Kristjansson
authors.forename: Andrei
authors.initials: A
authors.lastname: Manolescu
authors.forename: Arni
authors.initials: A
authors.lastname: Kristinsson
authors.forename: Thordur
authors.initials: T
authors.lastname: Hardarson
authors.forename: Helga
authors.initials: H
authors.lastname: Knudsen
authors.forename: Sigurdur
authors.initials: S
authors.lastname: Ingason
authors.forename: Gudmar
authors.initials: G
authors.lastname: Thorleifsson
authors.forename: Michael L
authors.initials: ML
authors.lastname: Frigge
authors.forename: Augustine
authors.initials: A
authors.lastname: Kong
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Gulcher
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
mesh_terms: D000328:Adult; D000368:Aged; D002887:Chromosomes, Human, Pair 18; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000235:genetics*; D007055:Iceland; D008297:Male; D008875:Middle Aged