title: A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues.
abstract: [structure: see text] A modified approach to the synthesis of 2-(N-aryl)-1,3-oxazoles, employing an optimized iminophosphorane/heterocumulene-mediated methodology, and its application to the synthesis of BMS-337197, a potent inhibitor of IMPDH, are described.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000, USA. dharm@bms.com
authors.forename: T G Murali
authors.initials: TG
authors.lastname: Dhar
authors.forename: Junqing
authors.initials: J
authors.lastname: Guo
authors.forename: Zhongqi
authors.initials: Z
authors.lastname: Shen
authors.forename: William J
authors.initials: WJ
authors.lastname: Pitts
authors.forename: Henry H
authors.initials: HH
authors.lastname: Gu
authors.forename: Bang-Chi
authors.initials: BC
authors.lastname: Chen
authors.forename: Rulin
authors.initials: R
authors.lastname: Zhao
authors.forename: Mark S
authors.initials: MS
authors.lastname: Bednarz
authors.forename: Edwin J
authors.initials: EJ
authors.lastname: Iwanowicz
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D010080:Oxazoles; D007168:IMP Dehydrogenase; C460179:BMS-337197