Sphingosine 1-phosphate signaling: providing cells with a sense of direction.
Sphingosine 1-phosphate (S1P) is a sphingolipid metabolite that regulates diverse biological functions. S1P has been identified as a high-affinity ligand for a family of five G-protein-coupled receptors, known as the S1P receptors. The physiological role of the S1P receptor S1P(1) in vascular maturation was recently revealed by gene disruption in mice. In addition to other cellular processes, the binding of S1P to its receptors regulates motility and directional migration of a variety of cell types, including endothelial cells and vascular smooth muscle cells. This review focuses on the important role of S1P and its receptors in cell migration and describes a new paradigm for receptor cross-communication in which transactivation of S1P(1) by a receptor tyrosine kinase (PDGFR) is crucial for cell motility.
Spiegel
Sarah
S
Dept of Biochemistry and Molecular Biophysics, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond 23298, USA. sspiegel@vcu.edu
English
Denis
D
Milstien
Sheldon
S
D000818:Animals; D002465:Cell Movement; D006801:Humans; D008246:Lysophospholipids; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D008958:Models, Molecular; D009369:Neoplasms / Q000378:metabolism; D018919:Neovascularization, Physiologic; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000235:genetics* / Q000502:physiology*; D015533:Transcriptional Activation; D020744:rac GTP-Binding Proteins / Q000378:metabolism
D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D020744:rac GTP-Binding Proteins; D013110:Sphingosine