[Function of clara cells in lung remodeling].
Clara cells localized in the bronchiole are thought to play a key role in lung remodeling. Clara cell secretory protein (CCSP), which is specifically produced by Clara cells, inhibits pro-inflammatory cytokines and chemotaxis of fibroblasts, and acts as phospholopase A2 inhibitors, and may also inhibit inflammation and fibrosis in the lung. This could be a biomarker of interstitial pneumonitis. Proliferation of Clara cells and neuroendocrine cells at airway epithelial injury may act as progenitor cells during the repair process.
Morimoto
Yasuo
Y
Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Yatera
Kazuhiro
K
D000818:Animals; D001980:Bronchi / Q000166:cytology*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D016207:Cytokines / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors; D006801:Humans; D008168:Lung / Q000473:pathology*; D008171:Lung Diseases / Q000473:pathology* / Q000503:physiopathology; D051379:Mice; D011506:Proteins / Q000502:physiology*; D011663:Pulmonary Surfactants / Q000502:physiology; D012907:Smoking; D014598:Uteroglobin
D016207:Cytokines; D004791:Enzyme Inhibitors; D011506:Proteins; D011663:Pulmonary Surfactants; C556389:SCGB1A1 protein, human; C556390:Scgb1a1 protein, mouse; D014598:Uteroglobin