title: HLA-DPB1 allelic frequency of the Pumi ethnic group in south-west China and evolutionary relationship of Pumi with other populations.
abstract: A sequencing-based typing of the HLA-DPB1 gene was carried out in 51 unrelated healthy individuals from the Yunnan Pumi ethnic minority. A total of 18 DPB1 alleles, in which DPB1*0501 (52.0%) and DPB1*0402 (15.7%) greatly predominated, were found, of which alleles DPB1*20011, 2201, 3601, 3701, 3801, 4901, 5001 and 8001 were recorded for the first time in the Chinese population. This may be because the typing methods used in previous genotyping of Chinese populations were of lower sensitivity than that used in our study. A dendrogram constructed by the maximum likelihood method showed that the Pumi ethnic minority belongs to the Asian/Australasian cluster and has the closest relationship to Trobriander, implying an unusual relationship between Australasian and South China populations. However, the Yi ethnic minority, which also comes from the ancient Qiang, did not show a very close relationship with the Pumi. This is probably because the Pumi were historically assimilated by local south-west China populations.
authors.affiliation: Department of Biochemistry, Guangzhou Center for Bioinformatics, College of Life Science, Zhongshan University, Guangdong, China.
authors.forename: Z-H
authors.initials: ZH
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Lin
authors.forename: D
authors.initials: D
authors.lastname: Pan
authors.forename: W
authors.initials: W
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Tao
authors.forename: A
authors.initials: A
authors.lastname: Xu
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D005006:Ethnicity / Q000235:genetics*; D019143:Evolution, Molecular; D005787:Gene Frequency; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D016013:Likelihood Functions; D010802:Phylogeny
chemical_list: D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen