title: Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus.
abstract: OBJECTIVE
  To determine the effects of subcortical ischemic vascular dementia (SIVD) and AD on entorhinal cortex (ERC) and hippocampus.
  
  
  METHODS
  Thirty-eight cognitively normal subjects, 18 patients with SIVD, and 22 patients with AD were included. Volumes of ERC and hippocampus were manually measured based on MRI. Global cerebral changes of cortical gray matter, subcortical gray matter, white matter, sulcal CSF, ventricular CSF (vCSF), and white matter signal hyperintensities (WMSH) were assessed.
  
  
  RESULTS
  Patients with SIVD had 21.7% (p < 0.01) smaller ERC and 18.2% (p < 0.01) smaller hippocampi than cognitively normal subjects and 24.4% (p < 0.01) larger ERC and 11.1% (p < 0.05) larger hippocampi than patients with AD. In addition, patients with SIVD had less cortical gray matter and white matter and more vCSF and WMSH (all p < 0.01) than cognitively normal subjects and more vCSF and WMSH (p < 0.01) than patients with AD. The volumes of ERC and hippocampus were positively correlated to similar extents (p < 0.01) in SIVD and AD. Cortical gray matter loss was positively correlated (p < 0.01) with hippocampal atrophy, but not with ERC atrophy, in SIVD and AD. Hippocampal volume alone could classify 82% of patients with SIVD from cognitively normal subjects and 63% of patients with SIVD from subjects with AD. Adding global cerebral changes to hippocampus substantially improved the classification to 96% between patients with SIVD and cognitively normal subjects and 83% between subjects with SIVD and those with AD, whereas adding ERC change to hippocampus did not significantly improve the discrimination.
  
  
  CONCLUSIONS
  The entorhinal cortex and hippocampus are less affected by subcortical ischemic vascular dementia than by AD.
authors.affiliation: Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Du
authors.forename: N
authors.initials: N
authors.lastname: Schuff
authors.forename: M P
authors.initials: MP
authors.lastname: Laakso
authors.forename: X P
authors.initials: XP
authors.lastname: Zhu
authors.forename: W J
authors.initials: WJ
authors.lastname: Jagust
authors.forename: K
authors.initials: K
authors.lastname: Yaffe
authors.forename: J H
authors.initials: JH
authors.lastname: Kramer
authors.forename: B L
authors.initials: BL
authors.lastname: Miller
authors.forename: B R
authors.initials: BR
authors.lastname: Reed
authors.forename: D
authors.initials: D
authors.lastname: Norman
authors.forename: H C
authors.initials: HC
authors.lastname: Chui
authors.forename: M W
authors.initials: MW
authors.lastname: Weiner
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D002545:Brain Ischemia / Q000473:pathology*; D015140:Dementia, Vascular / Q000473:pathology*; D003937:Diagnosis, Differential; D018728:Entorhinal Cortex / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D012680:Sensitivity and Specificity