Hypochlorite and Cu(2 ) Induced Oxidation of High Density Lipoprotein.
In order to further study on the properties of oxidatively modified high density lipoproteins(Ox-HDL), the effects of hypochlorite and Cu(2 ) on HDL oxidation in vitro were investigated. The results showed that, as to LDL, HDL was also oxidized by hypochlorite and Cu(2 ), causing the formation of thiobarbituric acid substances (TBARS) and increase of negative charges on HDL particle surface. It was also found that during the oxidation of hypochlorite, both apoAI and apoAII were degraded into small fragments, the phosphatidylcholine(PC) hydrolyzed into lysophosphatidylcholine (LPC) and the protein components of HDL formed carbonyls.
Fu
Qiang
Q
Apolipoproteins Research Unit, Institute of Biochemistry and Molecular Biology, West China University of Medical Sciences, Chengdu 610041, China. fucarl@mail.sc.cninfo.net
Liu
Bing-Wen
BW