The TRP channel and phospholipase C-mediated signaling.
Drosophila photoreceptors use a phospholipase C-mediated signaling for phototransduction. This pathway begins by light activation of a G-protein-coupled photopigment and ends by activation of the TRP and TRPL channels. The Drosophila TRP protein is essential for the high Ca2+ permeability and constitutes the major component of the light-induced current, thereby affecting both excitation and adaptation of the photoreceptor cell. TRP is the prototype of a large and diverse multigene family whose members are sharing a structure, which is conserved through evolution from the worm Caenorhabditis elegans to humans. TRP-related channel proteins are found in a variety of cells and tissues and show a large functional diversity although the gating mechanism of Drosophila TRP and of other TRP-related channels is still unknown.
Minke
B
B
Department of Physiology, Kühne Minerva Center for Studies of Visual Transduction, Hadassah Medical School, Hebrew University, Jerusalem, Israel.
D000818:Animals; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism*; D020013:Calcium Signaling / Q000235:genetics; D004330:Drosophila / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins; D020555:GTP-Binding Protein Regulators / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D017956:Photoreceptor Cells, Invertebrate / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*; D050051:Transient Receptor Potential Channels; D010738:Type C Phospholipases / Q000378:metabolism*; D014785:Vision, Ocular / Q000235:genetics*
D015220:Calcium Channels; D029721:Drosophila Proteins; D020555:GTP-Binding Protein Regulators; D019476:Insect Proteins; D050051:Transient Receptor Potential Channels; C063169:trp protein, Drosophila; D010738:Type C Phospholipases