title: Surgical management of isolated retroperitoneal recurrences of colorectal carcinoma.
abstract: OBJECTIVE
  Isolated locoregional disease accounts for approximately 20 percent of recurrences after treatment for colorectal cancer. It has been suggested that complete resection of these recurrences can result in increased survival. The value of surgery for isolated retroperitoneal recurrences has not been well defined. We have sought to characterize outcome and survival in patients undergoing resection for isolated retroperitoneal recurrences of colorectal cancer.
  
  
  METHODS
  From a prospective database, 25 patients were identified as having undergone surgical exploration with curative intent for isolated retroperitoneal recurrences of colorectal cancer between 1988 and 1999. Variables studied included age, gender, location and size of the tumor, extent of resection, disease-free interval, and morbidity and mortality. Statistical analyses were performed using the log-rank test and Kaplan-Meier estimates, with overall survival as the primary end point.
  
  
  RESULTS
  The study population consisted of 25 patients (13 males), with a median age of 55 years and a median follow-up of 29 (range, 1-151) months. The median time to first retroperitoneal recurrence was 23 (range, 3-72) months. Twenty patients underwent resection, whereas five patients were deemed unresectable at the time of operation. The median survival in patients who underwent resection patients was 31 months compared with 3 months in those patients who did not undergo resection (P = 0.0001). Analysis of the entire group demonstrated a disease-free interval of greater than 24 months to be a positive predictor of outcome (median survival, 30 vs. 48 months; P = 0.02). For patients undergoing resection, the presence of positive margins (P = 0.01) and tumor size >or=5 cm (P = 0.008) predicted a worse prognosis. In patients who underwent resection, the two-year and five-year overall survival rates were 60 and 15 percent, respectively.
  
  
  CONCLUSIONS
  Patients with isolated retroperitoneal recurrences of colorectal cancer generally have a poor prognosis. However, a longer disease-free interval, complete negative-margin resection, and smaller tumor size are associated with long-term survival in selected patients.
authors.affiliation: Division of Surgical Oncology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
authors.forename: David
authors.initials: D
authors.lastname: Shibata
authors.forename: Philip B
authors.initials: PB
authors.lastname: Paty
authors.forename: Jose G
authors.initials: JG
authors.lastname: Guillem
authors.forename: W Douglas
authors.initials: WD
authors.lastname: Wong
authors.forename: Alfred M
authors.initials: AM
authors.lastname: Cohen
mesh_terms: D002277:Carcinoma / Q000556:secondary* / Q000601:surgery*; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000556:secondary* / Q000601:surgery*