title: [Bilateral acute retinal necrosis due to herpes simplex virus in inmunocompetent people and acyclovir resistance].
abstract: METHODS
  A twenty-eight year old woman with necrotitizing retinitis and herpes simplex virus type 1 isolated in aqueous humor with polymerase chain reaction (PCR). An Acyclovir and corticosteroid therapy was started with unsuccessful response, Foscarnet was added getting quiescence of lesions.
  
  
  CONCLUSIONS
  Acute Retinal Necrosis Syndrome (ARNS), induced by a virus of the herpes family, could develop in immunocompetent people. A characteristic clinical case with uveitis and vitritis, white retinitis areas and occlusive vasculitis is reported. Antiviral therapy with acyclovir and antiinflammatory treatment must be established quickly. Foscarnet can effectively treat ARNS in inmunocompetent patients. In spite of therapy, this is a potentially blinding retinal disease.
authors.affiliation: Departamento de Oftalmología, Hospital General Universitario Gregorio Marañón, Madrid, España. domingoblanca@hotmail.com
authors.forename: B
authors.initials: B
authors.lastname: Domingo Gordo
authors.forename: J J
authors.initials: JJ
authors.lastname: Luezas Morcuende
authors.forename: P
authors.initials: P
authors.lastname: Vidal Fernández
authors.forename: M J
authors.initials: MJ
authors.lastname: Aparicio Hernández-Lastras
authors.forename: M
authors.initials: M
authors.lastname: Suárez Leoz
mesh_terms: D000208:Acute Disease; D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D017245:Foscarnet / Q000008:administration & dosage / Q000627:therapeutic use; D018259:Herpesvirus 1, Human / Q000302:isolation & purification; D006801:Humans; D016849:Keratitis, Herpetic / Q000150:complications* / Q000175:diagnosis; D009336:Necrosis; D016133:Polymerase Chain Reaction; D012160:Retina / Q000473:pathology; D012164:Retinal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D013997:Time Factors
chemical_list: D000998:Antiviral Agents; D017245:Foscarnet; D000212:Acyclovir
vernacular_title: Necrosis retiniana aguda bilateral por herpes simple en individuo inmunocompetentes y resistencia a aciclovir.