title: [Analysis of epileptic pregnant women delivering between 1992-1998 in obstetric departments of the University Medical School in Lublin].
abstract: Pregnancy in woman with epilepsy arouses several serious medical problems and always belongs to the group of high obstetric risks. The aim of the present clinical study was the evaluation of the antiepileptic treatment efficiency during pregnancy, including risk factor, effects on pregnancy and delivery in epileptic patients. The study group consisted of 84 epileptic pregnant women which delivered between 1992-1998 in Obstetric Departments of University Medical School of Lublin. A randomised group 80 healthy pregnant women constituted the control group. The mean age of the analysed patients was 25 years. 51 epileptic patients were pregnant for the first time, 23 patients for the second time and 10 patients for the third time or more. The mean duration time of the disease was 8.6 years. In our study group: 45 (53.8%) patients experienced primary generalized tonic-clonic seizures and 39 (46.6%) patients experienced partial seizures. 26 patients were treated with monotherapy and the rest with polytherapy methods. The estimation of the seizure frequency during pregnancy in 52 (61.9%) patients did not change, in 13 (15.4%) patients increased. Among obstetric complications: urinary tract infections, hypertonia (EPH-gestosis) were observed. In 4 newborn congenital defects have been noted. Mothers of three of them were treated with Phenydantin (heart lesion, developmental anomaly of fingers). The fourth mother used Convulex (meningoarachnided hernia, hydrocephalus).
authors.affiliation: Katedry i Kliniki Neurologii Akademii Medycznej w Lublinie.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Stelmasiak
authors.forename: Wiesława
authors.initials: W
authors.lastname: Semczuk
authors.forename: Beata
authors.initials: B
authors.lastname: Nowicka-Tarach
authors.forename: Iwona
authors.initials: I
authors.lastname: Halczuk
authors.forename: Anna
authors.initials: A
authors.lastname: Semczuk-Sikora
authors.forename: Marzena
authors.initials: M
authors.lastname: Laskowska
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008429:Maternal Welfare; D011044:Poland; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000503:physiopathology; D011256:Pregnancy Outcome; D012307:Risk Factors; D018709:Statistics, Nonparametric
chemical_list: D000927:Anticonvulsants
vernacular_title: Analiza przypadków kobiet chorujacych na padaczke rodzacych w lubelskich Klinikach Połozniczych w latach 1992-1998.