[Study of local anesthetics. CLX. Determination of the critical micellar concentration in a series of piperidinoethylesters of 3-alkoxyphenylcarbamic acid].
We have determined the critical micellar concentration (c.m.c) of the derivates type piperidinoethyl esters 3-alkoxy phenylcarbamic in the medium 0.05 mol/l and 0.2/mol/l NaCl for using spectrophotometry methods in the UV region of the spectrum at temperature T = 25 degrees C and pH = 4.5-5.0. We found the parabolic dependence of the -lin(c.m.c.) on the (n) number of the carbon in the alkoxy substituent chain. Further, we have observed the facility formation of the micelle at the solution of 0.2 mol/l than 0.05 mol/l NaCl.
Andriaminty
F
F
Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava. fils@fpharm.uniba.sk
Cizmárik
J
J
Mariscáková
Z
Z
D000779:Anesthetics, Local / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D008823:Micelles; D013056:Spectrophotometry, Ultraviolet
D000779:Anesthetics, Local; D002219:Carbamates; D008823:Micelles; C059692:phenylcarbamic acid
Stúdium lokálnych anestetík CLX. Stanovenie kritickej micelovej koncentrácie (c.m.c.) série piperidinoetylesterov 3-alkoxyfenylkarbámovej kyseliny.