Linkage of essential hypertension to chromosome 18q.
We performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P=2.1x 10(-6)). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes.
Kristjansson
Kristleifur
K
deCODE genetics, Inc, Reykjavik, Iceland. kris@ decode.is
Manolescu
Andrei
A
Kristinsson
Arni
A
Hardarson
Thordur
T
Knudsen
Helga
H
Ingason
Sigurdur
S
Thorleifsson
Gudmar
G
Frigge
Michael L
ML
Kong
Augustine
A
Gulcher
Jeffrey R
JR
Stefansson
Kari
K
D000328:Adult; D000368:Aged; D002887:Chromosomes, Human, Pair 18; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000235:genetics*; D007055:Iceland; D008297:Male; D008875:Middle Aged