title: Toxicity of lapachol and isolapachol and their potassium salts against Biomphalaria glabrata, Schistosoma mansoni cercariae, Artemia salina and Tilapia nilotica.
abstract: The toxicity of soluble derivatives (potassium salt) of lapachol and isolapachol in different stages of the life cycle of Schistosoma mansoni is evaluated. The potassium salts of isolapachol and lapachol showed significant molluscicidal activity against the adult snail (LC90<7 ppm) and snail egg masses (LC90<3 ppm). Cercaricidal assays revealed strong activities for both compounds. Lethality assays against brine shrimp eggs (Artemia salina Leach) indicated very high toxicity for the potassium salt of isolapachol (LC90=1.54 ppm), differently from the potassium salt of lapachol that can be considered non toxic (LC90=176.3 ppm). The same tendency is observed with piscicidal activity, for which the isolapachol salt has showed higher toxicity. The obtained selectivity ratios concerning LC50 and LC90 for lapachol, in relation to Tilapia nilotica lethality assay are 2.33 and 1.26, respectively. Despite the piscicidal toxicity, the use of the salt of lapachol can be recommended for field tests in Schistosomiasis, with caution.
authors.affiliation: Departamento de Química/CCEN Campus A.C. Simoes, Universidade Federal de Alagoas, Tabuleiro dos Martins Maceió, Alagoas, Brazil.
authors.forename: Nadja Maria Fernandes
authors.initials: NM
authors.lastname: Lima
authors.forename: Aldenir Feitosa
authors.initials: AF
authors.lastname: dos Santos
authors.forename: Zenaldo
authors.initials: Z
authors.lastname: Porfírio
authors.forename: Marília O F
authors.initials: MO
authors.lastname: Goulart
authors.forename: Antônio Euzébio G
authors.initials: AE
authors.lastname: Sant'Ana
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000633:toxicity*; D001156:Artemia / Q000187:drug effects; D001700:Biomphalaria / Q000187:drug effects*; D016001:Confidence Intervals; D008975:Molluscacides / Q000633:toxicity*; D009285:Naphthoquinones / Q000633:toxicity*; D021261:Parasitic Sensitivity Tests; D012550:Schistosoma mansoni / Q000187:drug effects*; D013329:Structure-Activity Relationship; D017210:Tilapia
chemical_list: D000871:Anthelmintics; D008975:Molluscacides; D009285:Naphthoquinones; C008252:lapachol