title: Optimal parametric sensitivity control for the estimation of kinetic parameters in bioreactors.
abstract: In this paper the well-known problem of optimal input design is considered. In particular, the focus is on input design for the estimation of kinetic parameters in bioreactors. The problem is formulated as follows: given the model structure (f,g), which is assumed to be affine in the input, and the specific parameter of interest theta;(k) find a feedback law that maximizes the sensitivity of the model output to the parameter under different flow conditions in the bioreactor and, possibly, minimize the input or state costs. Analytical solutions to these problems are presented. As an example a bioreactor with a biomass that grows according to the well-known Monod kinetics is considered.
authors.affiliation: Systems and Control Group, Wageningen University and Research Centre, Mansholtlaan 10-12, 6708, PA Wageningen, The Netherlands. karel.keesman@user.aenf.wau.nl
authors.forename: K J
authors.initials: KJ
authors.lastname: Keesman
authors.forename: J D
authors.initials: JD
authors.lastname: Stigter
mesh_terms: D019149:Bioreactors; D003198:Computer Simulation; D007700:Kinetics; D008954:Models, Biological