title: Effects of donepezil (Aricept) on the rapid eye movement sleep of normal subjects.
abstract: Donepezil (Aricept) is a therapeutic drug for the treatment of Alzheimer's disease (AD). However, there have been only two reports describing the effects of donepezil on sleep as assessed by nocturnal polysomnography (PSG). With this in mind, the effects of donepezil on the sleep of healthy subjects was evaluated using PSG. The results indicated that the percentage of rapid eye movement sleep to total sleep time was increased significantly by a single dose of 5 mg of donepezil when given to healthy subjects immediately before retiring to bed.
authors.affiliation: Department of Psychiatry, Akita University School of Medicine, Akita, Japan. takashik@psy.med.akita-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanbayashi
authors.forename: Tomonari
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Rika
authors.initials: R
authors.lastname: Aizawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Saito
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kitajima
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Masahito
authors.initials: M
authors.lastname: Abe
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000328:Adult; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage*; D018592:Cross-Over Studies; D000077265:Donepezil; D004311:Double-Blind Method; D006801:Humans; D007189:Indans / Q000008:administration & dosage*; D008297:Male; D010880:Piperidines / Q000008:administration & dosage*; D017286:Polysomnography; D012895:Sleep, REM / Q000187:drug effects*
chemical_list: D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D000077265:Donepezil