Potential use of beta(3)-adrenoceptor antagonists in heart failure therapy.
Recently, a functional, negatively inotropic, beta(3)-adrenoceptor was characterized in the human heart. Several studies now suggest that this receptor might play an important role in the pathophysiology of heart failure, by counterbalancing the effects of a beta(1)- and beta(2)-stimulation. Therefore, this review summarizes the rationale and effects of beta-adrenergic blockade in chronic heart failure and specifically addresses the question of the potential use of beta(3)-adrenoceptor antagonists in the treatment of heart failure and other pathophysiological conditions associated with a decreased cardiac contractility.
Moniotte
Stéphane
S
Department of Pediatrics, University of Louvain Medical School, Brussels, Belgium. moniotte@mint.ucl.ac.be
Balligand
Jean-Luc
JL
D058673:Adrenergic beta-3 Receptor Antagonists; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000818:Animals; D017776:Autonomic Pathways / Q000502:physiology; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D022702:Receptors, Adrenergic, beta-3 / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology
D058673:Adrenergic beta-3 Receptor Antagonists; D000319:Adrenergic beta-Antagonists; D022702:Receptors, Adrenergic, beta-3