title: Normothermia does not improve postoperative hemostasis nor does it reduce inflammatory activation in patients undergoing primary isolated coronary artery bypass.
abstract: BACKGROUND
  Despite its common acceptance in clinical practice, the effective benefits of normothermic systemic perfusion during coronary artery bypass operations are far from established.
  
  
  METHODS
  A total of 113 patients undergoing primary isolated coronary artery bypass were randomly assigned to normothermic (37 degrees C) or hypothermic (26 degrees C) systemic perfusion. The clinical course of the patients was prospectively recorded, and several inflammatory and fibrinolytic markers (C-reactive protein, fibrinogen, interleukin 6, plasminogen activator inhibitor 1, prothrombin time, activated partial thromboplastin time, platelets, and white blood cell counts) were determined before surgical intervention; 24, 48, and 72 hours thereafter; and at hospital discharge.
  
  
  RESULTS
  Postoperatively, 2 in-hospital deaths occurred in the normothermic series and none in the hypothermic series. Four patients had a myocardial infarction, 1 had respiratory insufficiency, 1 had to be reoperated on for graft malfunction, and none had renal insufficiency in the hypothermic group versus 1 patient with each of these complications in the normothermic series. Mean blood loss in the first 24 hours was 766 +/- 223 mL in the normothermic group and 740 +/- 220 mL in the hypothermic group. None of these differences was statistically significant. Similarly, no significant difference in the postoperative level of any of the measured variables at any time point was evident between the patients in the normothermic and hypothermic groups.
  
  
  CONCLUSIONS
  Normothermic systemic perfusion does not influence the clinical course or the extent of inflammatory and hemostatic activation in patients undergoing primary isolated coronary artery bypass.
authors.affiliation: Department of Cardiac Surgery, Catholic University, Rome, Italy. mgaudino@tiscalinet.it
authors.forename: Mario
authors.initials: M
authors.lastname: Gaudino
authors.forename: Roberto
authors.initials: R
authors.lastname: Zamparelli
authors.forename: Felicita
authors.initials: F
authors.lastname: Andreotti
authors.forename: Francesco
authors.initials: F
authors.lastname: Burzotta
authors.forename: Licia
authors.initials: L
authors.lastname: Iacoviello
authors.forename: Franco
authors.initials: F
authors.lastname: Glieca
authors.forename: Maria
authors.initials: M
authors.lastname: Benedett
authors.forename: Attilio
authors.initials: A
authors.lastname: Maseri
authors.forename: Rocco
authors.initials: R
authors.lastname: Schiavello
authors.forename: Gianfederico
authors.initials: G
authors.lastname: Possati
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis; D002315:Cardiopulmonary Bypass / Q000379:methods*; D001026:Coronary Artery Bypass; D005260:Female; D006488:Hemostasis, Surgical; D006801:Humans; D007036:Hypothermia, Induced; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011184:Postoperative Period; D011446:Prospective Studies
chemical_list: D015850:Interleukin-6; D017395:Plasminogen Activator Inhibitor 1; D002097:C-Reactive Protein