The new stem cell biology.
Recent studies have indicated that bone marrow stem cells are capable of generating muscle, cardiac, hepatic, renal, and bone cells. Purified hematopoietic stem cells have generated cardiac and hepatic cells and reversed disease manifestations in these tissues. Hematopoietic stem cells also alter phenotype with cell cycle transit or circadian phase. During a cytokine stimulated cell cycle transit, reversible alterations of differentiation and engraftment occur. Primitive hematopoietic stem cells express a wide variety of adhesion and cytokine receptors and respond quickly with migration and podia extensions on exposure to cytokines. These data suggest an "Open Chromatin" model of stem cell regulation in which there is a fluctuating continuum in the stem cell/progenitor cell compartments, rather than a hierarchical relationship. These observations, along with progress in using low dose treatments and tolerization approaches, suggest many new therapeutic strategies involving stem cells and the creation of a new medical specialty; stemology.
Quesenberry
Peter J
PJ
Department of Research, Roger Williams Medical Center, 825 Chalkstone Avenue, Providence, RI 02908, USA. pquesenberry@rwmc.org
Colvin
Gerald A
GA
Lambert
Jean-Francois
JF
Frimberger
Angela E
AE
Dooner
Mark S
MS
Mcauliffe
Christina I
CI
Miller
Caroline
C
Becker
Pamela
P
Badiavas
Evangelis
E
Falanga
Vincent J
VJ
Elfenbein
Gerald
G
Lum
Lawrence G
LG
D000818:Animals; D002469:Cell Separation; D002678:Chimera; D002843:Chromatin / Q000235:genetics; D005260:Female; D015870:Gene Expression; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology; D006801:Humans; D008297:Male; D051379:Mice; D020297:Mice, Congenic; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D009369:Neoplasms / Q000628:therapy; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D002843:Chromatin