title: Methylenetetrahydrofolate reductase genotype does not play a role in multiple myeloma pathogenesis.
abstract: Methylenetetrahydrofolate reductase (MTHFR) plays an important role in carcinogenesis. A decreased incidence of cancer has been reported in the presence of MTHFR 677TT, 1298AC and 1298CC polymorphic variants. We have analysed the MTHFR genotype in 107 multiple myeloma (MM) patients and 86 controls. The MM and control polymorphisms frequencies were: 34% and 48% for 677CC, 53% and 41% for 677CT, 12% and 11% for 677TT; 36% and 43% for 1298AA, 51% and 44% for 1298AC; and 12% and 13% for 1298CC respectively. No statistically significant differences were observed. In addition, no differences were seen according to MM stage, presence of p16 gene hypermethylation or response to treatment.
authors.affiliation: Servicio de Hematología, Hospital Clínico Universitario de Salamanca, Centro de Investigación del Cáncer (CIC), Paseo de San Vicente 58-182, 37007 Salamanca, Spain.
authors.forename: Maria I
authors.initials: MI
authors.lastname: González-Fraile
authors.forename: Ramoń
authors.initials: R
authors.lastname: García-Sanz
authors.forename: Maria V
authors.initials: MV
authors.lastname: Mateos
authors.forename: Ana
authors.initials: A
authors.lastname: Balanzategui
authors.forename: Marcos
authors.initials: M
authors.lastname: González
authors.forename: Lourdes
authors.initials: L
authors.lastname: Váquez
authors.forename: Jesús F
authors.initials: JF
authors.lastname: San Miguel
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005787:Gene Frequency; D019942:Genes, p16; D006801:Humans; D008745:Methylation; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009101:Multiple Myeloma / Q000209:etiology / Q000235:genetics*; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)