Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
The hematopathology subcommittee of the Mouse Models of Human Cancers Consortium recognized the need for a classification of murine hematopoietic neoplasms that would allow investigators to diagnose lesions as well-defined entities according to accepted criteria. Pathologists and investigators worked cooperatively to develop proposals for the classification of lymphoid and nonlymphoid hematopoietic neoplasms. It is proposed here that nonlymphoid hematopoietic neoplasms of mice be classified in 4 broad categories: nonlymphoid leukemias, nonlymphoid hematopoietic sarcomas, myeloid dysplasias, and myeloid proliferations (nonreactive). Criteria for diagnosis and subclassification of these lesions include peripheral blood findings, cytologic features of hematopoietic tissues, histopathology, immunophenotyping, genetic features, and clinical course. Differences between murine and human lesions are reflected in the terminology and methods used for classification. This classification will be of particular value to investigators seeking to develop, use, and communicate about mouse models of human hematopoietic neoplasms.
Kogan
Scott C
SC
Comprehensive Cancer Center and Department of Laboratory Medicine, University of California, San Francisco, 94143, USA. skogan@cc.ucsf.edu
Ward
Jerrold M
JM
Anver
Miriam R
MR
Berman
Jules J
JJ
Brayton
Cory
C
Cardiff
Robert D
RD
Carter
John S
JS
de Coronado
Sherri
S
Downing
James R
JR
Fredrickson
Torgny N
TN
Haines
Diana C
DC
Harris
Alan W
AW
Harris
Nancy Lee
NL
Hiai
Hiroshi
H
Jaffe
Elaine S
ES
MacLennan
Ian C M
IC
Pandolfi
Pier Paolo
PP
Pattengale
Paul K
PK
Perkins
Archibald S
AS
Simpson
R Mark
RM
Tuttle
Mark S
MS
Wong
Joanne F
JF
Morse
Herbert C
HC
D000818:Animals; D019337:Hematologic Neoplasms / Q000145:classification* / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000145:classification / Q000473:pathology; D051379:Mice; D009196:Myeloproliferative Disorders / Q000145:classification / Q000473:pathology; D009316:National Institutes of Health (U.S.); D009436:Neural Tube Defects / Q000145:classification / Q000473:pathology; D012509:Sarcoma / Q000145:classification / Q000473:pathology; D014481:United States