title: Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia.
abstract: The gene encoding a transmembrane glycoprotein LIG-1, of which the extracellular region was organized with the leucine-rich repeats and immunoglobulin-like domains, was disrupted in mice by gene targeting. LIG-1-deficient mice developed a skin change on the tail and facial area after birth. The affected skin was histologically reminiscent of the epidermis in human common skin disease 'psoriasis'. LIG-1 was expressed in basal cells of the epidermis and outer root sheath cells of hair follicles in mice. Interestingly, the LIG-1 expression was apparently down-regulated in the psoriatic lesions, suggesting that LIG-1 inversely correlates with proliferative ability of epidermal keratinocytes.
authors.affiliation: Read Generation Laboratory, Tanabe Seiyaku Co. Ltd., 3-16-89 Kashima, Yodogawa-ku, Osaka, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tanemura
authors.forename: Kinji
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Gen
authors.initials: G
authors.lastname: Kondoh
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Sano
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ozawa
authors.forename: Shigeki
authors.initials: S
authors.lastname: Inui
authors.forename: Aya
authors.initials: A
authors.lastname: Nakata
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takagi
authors.forename: Masaya
authors.initials: M
authors.lastname: Tohyama
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Itami
mesh_terms: D000015:Abnormalities, Multiple / Q000378:metabolism / Q000473:pathology; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D002455:Cell Division; D018076:DNA, Complementary; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D018390:Gene Targeting; D006801:Humans; D015603:Keratinocytes / Q000166:cytology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D011565:Psoriasis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D012868:Skin Abnormalities / Q000378:metabolism / Q000473:pathology
chemical_list: D018076:DNA, Complementary; C484445:LRIG1 protein, human; C101671:Lrig1 protein, mouse; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins