Synthesis and immunological effect of thymic humoral factor-gamma-2 analogues.
Nine analogues of thymic humoral factor (THF)-gamma-2 were prepared by the solid-phase method, and their in vitro restoring effect on the impaired blastogenic response of phytohemagglutinin(PHA)-stimulated T-lymphocytes of uremic patients with infectious diseases were examined. The results were as follows: [Arg6]-THF-gamma-2 exhibited higher restoring activity than that of our synthetic THF-gamma-2. [Sar4]-, [Val1]-, [Arg3]-, [Gly5]-, and [Asn3]-THF-gamma-2 were also active but less potent than that of our synthetic THF-gamma-2. Three other peptides, [beta-Ala4]-, [Arg2]-, and [Gln2]-THF-gamma-2, did not show any restoring activity on the impaired blastogenic response of uremic patients with infectious disease.
Abiko
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Research Laboratory, Global Shinwa Pharmaceutical Co. Ltd, Iwate-gun, Iwate-ken, Japan. lab@mx2.alpha-web.ne.jp
Ogawa
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D000595:Amino Acid Sequence; D006801:Humans; D007111:Immunity, Cellular; D007202:Indicators and Reagents; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000276:immunology*; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry; D013951:Thymus Hormones / Q000138:chemical synthesis / Q000276:immunology; D014511:Uremia / Q000276:immunology
D007202:Indicators and Reagents; D009842:Oligopeptides; D010446:Peptide Fragments; D013951:Thymus Hormones; C064563:thymic humoral factor gamma 2