Genetic profile of acute myeloid leukemia.
Understanding genomic events and the cascade of their effects in cell function is crucial for identifying distinct subsets of acute myeloid leukemia and developing new therapeutic strategies. Conventional cytogenetics, fluorescence in situ hybridization investigations and molecular studies have provided much information over the past few years. This review will focus on major genomic mechanisms in acute myeloid luekemia and on the genes implicated in the pathogenesis of specific subtypes.
Mecucci
Cristina
C
Hematology and Bone Marrow Transplantation Unit, University of Perugia, Italy. crimecux@unipg.it
Rosati
Roberto
R
Starza
Roberta La
RL
D000208:Acute Disease; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D006801:Humans; D007951:Leukemia, Myeloid / Q000145:classification / Q000209:etiology / Q000235:genetics*; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics
D009363:Neoplasm Proteins