Thrombophilia and pregnancy loss.
Thrombophilia is defined as a tendency to thrombosis. The association between specific thrombophilic defects--both inherited and acquired--and pregnancy loss is a rapidly developing field. However, apart from antiphospholipid antibodies (aPL), an acquired thrombophilic defect, the role of other defects in the haemostatic pathways remains to be established. In this invited review we discuss the recent advances in our understanding of aPL related pregnancy loss, the association between genetic thrombophilic mutations and pregnancy outcome and the role of whole blood haemostasis testing in the investigation of women with recurrent miscarriage.
Regan
Lesley
L
Department of Reproductive Science and Medicine, Imperial College School of Medicine at St. Mary's, Mint Wing, South Wharf Road, London W2 1NY, UK. l.regan@ic.ac.uk
Rai
Raj
R
D000026:Abortion, Habitual / Q000209:etiology / Q000235:genetics; D000022:Abortion, Spontaneous / Q000209:etiology* / Q000517:prevention & control; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000188:drug therapy; D001241:Aspirin / Q000627:therapeutic use; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology; D011256:Pregnancy Outcome; D013916:Thrombelastography; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis / Q000235:genetics
D006493:Heparin; D001241:Aspirin