title: Sex differences in the incidence of total callosal agenesis in BALB/cCF mice.
abstract: Corpus callosum (CC) development and adult morphology seems to be affected by sex. Here we analyzed the incidence of total callosal agenesis in 341 adult male and 318 female BALB/cCF mice. This strain of mice presents total or partial callosal agenesis in approximately 20-30% of its population. No significant differences were found in overall distributions of CC lengths and in average callosal lengths (totally acallosal excluded) between male and female mice. However, a highly significant difference in the incidence of total callosal agenesis was demonstrated: 18% (n=56) of the female mice presented such trait as opposed to 10% of males (n=34). This last result suggests that sex is a relevant factor in callosal development in its earliest stages of formation.
authors.affiliation: Laboratório de Neurofisiologia e Avaliação Neurocomportamental, Departamento de Ciências Fisiológicas, IBRAG, Universidade do Estado do Rio de Janeiro, Boulevard 28 de Setembro, 87, Fundos, 5 andar, Rio de Janeiro 20.551-030, Brazil. amanhaes@uerj.br
authors.forename: Alex C
authors.initials: AC
authors.lastname: Manhães
authors.forename: Alexandre E
authors.initials: AE
authors.lastname: Medina
authors.forename: Sergio L
authors.initials: SL
authors.lastname: Schmidt
mesh_terms: D061085:Agenesis of Corpus Callosum; D000818:Animals; D001927:Brain Diseases / Q000235:genetics*; D004195:Disease Models, Animal; D005260:Female; D015994:Incidence; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012727:Sex Characteristics