Effects of donepezil (Aricept) on the rapid eye movement sleep of normal subjects.
Donepezil (Aricept) is a therapeutic drug for the treatment of Alzheimer's disease (AD). However, there have been only two reports describing the effects of donepezil on sleep as assessed by nocturnal polysomnography (PSG). With this in mind, the effects of donepezil on the sleep of healthy subjects was evaluated using PSG. The results indicated that the percentage of rapid eye movement sleep to total sleep time was increased significantly by a single dose of 5 mg of donepezil when given to healthy subjects immediately before retiring to bed.
Kanbayashi
Takashi
T
Department of Psychiatry, Akita University School of Medicine, Akita, Japan. takashik@psy.med.akita-u.ac.jp
Sugiyama
Tomonari
T
Aizawa
Rika
R
Saito
Yasushi
Y
Ogawa
Yuriko
Y
Kitajima
Tsuyoshi
T
Kaneko
Yoshihiko
Y
Abe
Masahito
M
Shimizu
Tetsuo
T
D000328:Adult; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage*; D018592:Cross-Over Studies; D000077265:Donepezil; D004311:Double-Blind Method; D006801:Humans; D007189:Indans / Q000008:administration & dosage*; D008297:Male; D010880:Piperidines / Q000008:administration & dosage*; D017286:Polysomnography; D012895:Sleep, REM / Q000187:drug effects*
D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D000077265:Donepezil