title: Cutaneous metastasis of gestational choriocarcinoma.
abstract: A 40-year-old woman presented with subcutaneous masses on her chest wall, abnormal vaginal bleeding and an enlarged uterus. Chest X-ray and liver ultrasound revealed metastatic disease to these sites, respectively. A urine human chorionic gonadotrophin assay was positive. A biopsy of the chest wall lesion and endometrium revealed choriocarcinoma. Treatment with methotrexate, actinomycin-D and cyclophosphamide led to complete resolution of the disease on examination, X-ray and ultrasound scans. The urinary pregnancy test became negative.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Maiduguri Teaching Hospital, Nigeria.
authors.forename: C M
authors.initials: CM
authors.lastname: Chama
authors.forename: H A
authors.initials: HA
authors.lastname: Nggada
authors.forename: A
authors.initials: A
authors.lastname: Nuhu
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D002822:Choriocarcinoma / Q000188:drug therapy / Q000556:secondary*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008727:Methotrexate / Q000008:administration & dosage; D011247:Pregnancy; D011258:Pregnancy Tests; D012878:Skin Neoplasms / Q000188:drug therapy / Q000556:secondary*; D014594:Uterine Neoplasms / Q000473:pathology*
chemical_list: D003609:Dactinomycin; D003520:Cyclophosphamide; D008727:Methotrexate