title: Disruption of thermal perception in a multiple sclerosis patient with central pain.
abstract: OBJECTIVE
  To investigate integrative thermal perception in a patient with multiple sclerosis.
  
  
  METHODS
  Quantitative thermosensory testing was used to evaluate pain and other sensations produced by heat, cold, and the thermal grill pain illusion.
  
  
  METHODS
  The authors report on a 43-year-old patient with central pain manifest most strongly in her left arm and hand, contralateral to an upper cervical spinothalamic lesion due to multiple sclerosis.
  
  
  RESULTS
  Quantitative thermosensory testing showed that the patient had heat hypalgesia (no pain with stimuli of 45-50 degrees C) and cold allodynia (pain with innocuous cool temperatures, 25-10 degrees C). Whereas healthy subjects rated 20 degrees and 40 degrees C as nonpainful, but the thermal grill (intermixed 20 and 40 degrees C stimuli) as painful, the patient rated the thermal grill as less painful than 20 degrees C.
  
  
  CONCLUSIONS
  The absence of thermal grill-evoked pain is consistent with the hypothesis that in some cases of central pain the loss of the thermosensory pathway results in disruption of the normal cold inhibition of burning pain.
authors.affiliation: Department of Anesthesiology, McGill University, Montréal, Québec, Canada.
authors.forename: Chantal
authors.initials: C
authors.lastname: Morin
authors.forename: M Catherine
authors.initials: MC
authors.lastname: Bushnell
authors.forename: Marla B
authors.initials: MB
authors.lastname: Luskin
authors.forename: A D Bud
authors.initials: AD
authors.lastname: Craig
mesh_terms: D000328:Adult; D003080:Cold Temperature; D005260:Female; D006358:Hot Temperature; D006801:Humans; D006930:Hyperalgesia / Q000209:etiology / Q000503:physiopathology; D006941:Hyperesthesia / Q000209:etiology / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000150:complications* / Q000503:physiopathology*; D010146:Pain / Q000209:etiology* / Q000503:physiopathology*; D010147:Pain Measurement; D012016:Reference Values; D013697:Thermosensing