title: Toxicological effects of the herbicide oxyfluorfen on acetylcholinesterase in two fish species: Oreochromis niloticus and Gambusia affinis.
abstract: The alterations of the AChE activity in the brains of two fresh water fishes; Oreochromis niloticus and Gambusia affinis were measured after exposure to acute, sub-acute and chronic concentrations from the widely used herbicide; oxyfluorfen. Bioassays were conducted under controlled laboratory conditions. The used concentrations were acute: LC50 for 6 days, sub-acute 1/3 LC50 for 15 days and chronic 1/10 LC50 for 30 days. The obtained results showed marked inhibitory effects of the herbicide on the activity of AChE in both fishes. However, these effects were more pronounced in O. niloticus where the decline in the enzyme activity ranged from 19.7 to 81.28% while in case of G. affinis it ranged from 5.7 to 36.7%. These findings demonstrate that G. affinis is most tolerant to oxyfluorfen toxicity compared with O. niloticus.
authors.affiliation: Zoology Department, Faculty of Science at Sohag, South Valley University, Egypt. hamada10@mailcity.com
authors.forename: Hamdy M A
authors.initials: HM
authors.lastname: Hassanein
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects* / Q000494:pharmacology*; D000222:Adaptation, Physiological; D000818:Animals; D023681:Cichlids / Q000502:physiology*; D003532:Cyprinodontiformes / Q000502:physiology*; D055768:Halogenated Diphenyl Ethers; D006540:Herbicides / Q000633:toxicity*; D007928:Lethal Dose 50; D010647:Phenyl Ethers / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D055768:Halogenated Diphenyl Ethers; D006540:Herbicides; D010647:Phenyl Ethers; D014874:Water Pollutants, Chemical; C016027:oxyfluorofen; D000110:Acetylcholinesterase