Terpenes from Juniperus przewalskii and their antitumor activities.
Two new diterpenes were isolated from Juniperus przewalskii, together with 17 known terpense. Their structures were elucidated by spectroscopic methods (IR, MS, 1H, 13C and 2DNMR). In addition, 3 alpha-hinokiol (3) and 3 alpha-hydroxymannol (9) exhibited effective antitumor activities to cervical carcinoma (HeLa) and human ovarian carcinoma (HO-8910) cell lines.
Wang
Wen-Shu
WS
Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, P.R. China.
Li
Er-Wei
EW
Jia
Zhong-Jian
ZJ
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology*; D002681:China; D005260:Female; D006367:HeLa Cells; D006801:Humans; D018653:Juniperus / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009904:Optical Rotation; D010051:Ovarian Neoplasms / Q000188:drug therapy; D013055:Spectrophotometry, Infrared; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes