Vascular restenosis. Basic science and clinical implications.
Cardiovascular interventions to correct arterial occlusive disease have excellent short-term results, but long-term patency is still seriously compromised by the development of restenosis. This review will provide a portrait of the mechanisms following vascular injury, define the clinical scope of the problem and outline developments of different therapeutical strategies to prevent restenosis.
Heckenkamp
J
J
Department of Surgery, Division of Vascular Surgery, University of Cologne, Cologne, Germany. j_heckenkamp@hotmail.com
Gawenda
M
M
Brunkwall
J
J
D000800:Angioplasty, Balloon; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy; D019917:Blood Vessel Prosthesis Implantation; D003251:Constriction, Pathologic / Q000503:physiopathology / Q000601:surgery / Q000628:therapy; D004691:Endarterectomy; D015316:Genetic Therapy; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D010778:Photochemotherapy; D010975:Platelet Aggregation Inhibitors; D011878:Radiotherapy; D015912:Thrombolytic Therapy
D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D000960:Hypolipidemic Agents; D010975:Platelet Aggregation Inhibitors