title: Effects of two preanesthetic regimens for ophthalmic surgery on intraocular pressure and cardiovascular measurements in dogs.
abstract: The effects of different preanesthetic medications (acepromazine plus either meperidine or butorphanol) given before the induction of anesthesia with midazolam and ketamine on intraocular pressure, heart rate, and arterial blood pressure were investigated in 20 dogs. Following administration of preanesthetics and induction of anesthesia, dogs were intubated and anesthesia was maintained with halothane for 10 minutes. Intraocular pressure was significantly higher (P <.05) at several evaluations for dogs premedicated with acepromazine/meperidine than for those premedicated with acepromazine/butorphanol. Mean heart rate and diastolic arterial blood pressure were significantly (P <.05) higher 5 minutes after administration of acepromazine/meperidine than after acepromazine/butorphanol. Results of this study suggest that acepromazine/butorphanol is a satisfactory preanesthetic combination to use before induction of anesthesia with midazolam and ketamine for ophthalmic surgery in dogs.
authors.affiliation: Department of Surgery, University of São Paulo, School of Veterinary Medicine of Brazil, Brazil.
authors.forename: Eunice Yuriko
authors.initials: EY
authors.lastname: Tamura
authors.forename: Paulo Sergio de Moraes
authors.initials: PS
authors.lastname: Barros
authors.forename: Silvia Renata Gaido
authors.initials: SR
authors.lastname: Cortopassi
authors.forename: Aline Magalhães
authors.initials: AM
authors.lastname: Ambrósio
authors.forename: Denise Tabacchi
authors.initials: DT
authors.lastname: Fantoni
mesh_terms: D000075:Acepromazine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002077:Butorphanol / Q000008:administration & dosage / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects*; D004285:Dogs / Q000502:physiology* / Q000601:surgery; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008614:Meperidine / Q000008:administration & dosage / Q000494:pharmacology*; D013508:Ophthalmologic Surgical Procedures / Q000662:veterinary; D011229:Preanesthetic Medication / Q000662:veterinary*; D012016:Reference Values
chemical_list: D000075:Acepromazine; D008614:Meperidine; D002077:Butorphanol