[Melanoma on congenital nevus. Malignant differentiation after radiotherapy?].
Giant congenital nevi involve an approximately 5% risk of malignant transformation. We report about a 27-year-old patient who developed malignant melanoma after radiation of a large congenital nevus of the foot which was initially misinterpreted as a trophic disorder. The mechanisms and probability of malignant transformation and prophylactic therapy of large vs small congenital nevi are discussed.
Gaube
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K
Hautklinik am Klinikum Nürnberg, Prof.-Ernst-Nathan-Strasse 1, 90419 Nürnberg.
Paul
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E
D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology; D009508:Nevus, Pigmented / Q000151:congenital / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000151:congenital / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy
Melanom auf kongenitalem Naevus. Maligne Entartung nach Strahlentherapie?