Associations of serum concentrations of IgG, IgA, IgM and interleukin-1beta with early-onset periodontitis classification and race.
BACKGROUND
The significance of serum concentrations of various antibodies and cytokines in the pathogenesis of early-onset periodontitis (EOP) is not well understood. Recent reports suggest differences between young blacks and whites in certain humoral responses, regardless of periodontal status. This study was undertaken to compare the serum concentrations of IgG, IgA, IgM, and IL-1beta in EOP subjects with that of healthy controls, and to study the effect of race on these levels.


METHODS
This case-control study included 228 individuals, 19-25 years old who were selected from a larger population examined in the National Survey of Oral Health of United States Children in 1986/1987. The subjects were classified by their EOP status and they included 166 subjects with EOP and 62 healthy controls. Blood samples were used to assess the serum concentrations of IgG, IgM, IgA, IgG subclass, and IL-1beta.


RESULTS
The serum concentrations of IgG, IgG subclasses, IgA, and IgM in blacks were not significantly different in the generalized, localized and incidental EOP groups as compared to the healthy controls. The serum IL-1beta concentration was slightly and uniformly lower in the EOP groups than in the control group, although not statistically significant. Blacks had significantly higher serum concentrations of total IgG, and of IgG1, IgG2 and IgG3 than whites and Hispanics. Hispanics had significantly higher serum concentrations of IgM and IgG4 than whites and blacks. Hispanics also had a significantly higher serum concentration of IL-1beta than blacks.


CONCLUSIONS
Total antibody response in blacks is not associated with EOP classification. Race has a significant effect on serum antibody concentrations irrespective of disease classification, with blacks having significantly higher serum concentrations of IgG1, IgG2 and IgG3 than whites and Hispanics.
Albandar
Jasim M
JM
Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA 19140, USA. jalbandar@dental.temple.edu
DeNardin
Ann M
AM
Adesanya
Margo R
MR
Winn
Deborah M
DM
Diehl
Scott R
SR
D000328:Adult; D010520:Aggressive Periodontitis / Q000145:classification* / Q000276:immunology; D000704:Analysis of Variance; D000917:Antibody Formation / Q000276:immunology; D044383:Black People; D016022:Case-Control Studies; D005006:Ethnicity; D005260:Female; D005500:Follow-Up Studies; D006630:Hispanic or Latino; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood* / Q000145:classification; D007075:Immunoglobulin M / Q000097:blood*; D007375:Interleukin-1 / Q000097:blood*; D008297:Male; D017622:Periodontal Attachment Loss / Q000145:classification / Q000276:immunology; D016388:Tooth Loss / Q000145:classification / Q000276:immunology; D044465:White People
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007375:Interleukin-1