Non-linear mixed effects models for the evaluation of dissolution profiles.
The use of non-linear mixed effects models to describe dissolution data has been evaluated. A theoretical part is included to introduce this approach to scientists who are not familiar with this type of statistics. The standard settings of the statistical software package (S-plus) are used as much as possible. Several mathematical functions like the Weibull, logistic, first-order and Gompertz are employed as basis for the non-linear mixed effects models. Examples are given using dissolution data of immediate and extended release tablets. The results are compared with those obtained using linear mixed effects models.
Adams
E
E
Pharmaceutical and Biomedical Analysis, Pharmaceutical Institute, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, Brussels, Belgium. eadams@fabi.vub.ac.be
Coomans
D
D
Smeyers-Verbeke
J
J
Massart
D L
DL
D016014:Linear Models; D015233:Models, Statistical; D012984:Software; D012995:Solubility; D013607:Tablets
D013607:Tablets