Identification of a new MICA allele, MICA*047.
The MHC Class I related (MIC) gene family has been shown to be very polymorphic with 46 different MICA alleles being officially named by the WHO Nomenclature Committee for factors of the HLA system to date. We have identified a novel MICA allele, MICA*047, in a Coya American Indian individual from the Jujuy province of north-western Argentina. The novel MICA*047 allele differs from the MICA*030 allele by a single non-synonymous substitution in exon 2, condon 26 GTA-->GGA, Valine to Glycine1.
Pérez-Rodríguez
M
M
Anthony Nolan Research Institute, The Royal Free Hospital, London, UK.
Raimondi
E
E
Marsh
Steven G E
SG
Madrigal
J A
JA
D000483:Alleles; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000145:classification / Q000235:genetics*; D006801:Humans; D007199:Indians, South American / Q000235:genetics; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A