title: Polymorphisms in various coagulation genes in black South African women with placental abruption.
abstract: This pilot study examined Factor V Leiden (R506Q), prothrombin (20210G-->A), thrombomodulin (A455V) and MTHFR (677C-->T) in 100 Zulu-speaking black South African women with placental abruption and 217 controls. The Factor V Leiden and prothrombin variant gene alleles were not detected in either patient or control groups. The thrombomodulin polymorphic variant was not seen in the patient group but three heterozygotes (1%) were found in the controls. No homozygotes for the MTHFR T677 variant were detected in the patients but two (1%) were noted in the controls; the normal and heterozygote genotype and allele frequencies for this polymorphism were similar in the two groups.
authors.affiliation: Department of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa.
authors.forename: B
authors.initials: B
authors.lastname: Hira
authors.forename: R J
authors.initials: RJ
authors.lastname: Pegoraro
authors.forename: L
authors.initials: L
authors.lastname: Rom
authors.forename: T
authors.initials: T
authors.lastname: Govender
authors.forename: J
authors.initials: J
authors.lastname: Moodley
mesh_terms: D000037:Abruptio Placentae / Q000208:ethnology / Q000235:genetics*; D044383:Black People / Q000235:genetics; D005165:Factor V / Q000235:genetics; D005260:Female; D006579:Heterozygote; D006801:Humans; D010865:Pilot Projects; D011110:Polymorphism, Genetic / Q000235:genetics*; D011247:Pregnancy; D011516:Prothrombin / Q000235:genetics; D013019:South Africa / Q000208:ethnology; D018180:Thrombomodulin / Q000235:genetics
chemical_list: D018180:Thrombomodulin; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin