title: Effects of pretraining intrastriatal administration of p-chloroamphetamine on inhibitory avoidance.
abstract: Pretraining systemic administration of p-chloroamphetamine (PCA) consistently produces retention deficits of inhibitory avoidance. This drug causes a widespread acute release of serotonin from cerebral neuronal terminals, but it is not known where in the brain PCA exerts its disruptive cognitive effects. The present experiment was aimed at determining whether the striatum is a site of action of this drug. PCA (5 microg) was infused, bilaterally, into the striatum of rats at 30, 15, or 5 min before training of inhibitory avoidance, and retention of the task was measured 24 h later. An inversely related time-dependent deficit was found. Together with the results from appropriate control groups, this result strongly suggest that systemic PCA produces its reported cognitive effects, at least in part, through its pharmacological action within the striatum.
authors.affiliation: Center of Neurobiology, and Department of Physiology, Gaculty of Medicine, National University of Mexico, Mexico D.F. 04510, Mexico.
authors.forename: Rafael
authors.initials: R
authors.lastname: Solana-Figueroa
authors.forename: Rigoberto
authors.initials: R
authors.lastname: Salado-Castillo
authors.forename: Luisa E
authors.initials: LE
authors.lastname: Galindo
authors.forename: Gina L
authors.initials: GL
authors.lastname: Quirarte
authors.forename: Roberto A
authors.initials: RA
authors.lastname: Prado-Alcalá
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects*; D007266:Inhibition, Psychological; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018490:Serotonin Agents / Q000494:pharmacology*; D013663:Teaching; D010133:p-Chloroamphetamine / Q000494:pharmacology*
chemical_list: D018490:Serotonin Agents; D010133:p-Chloroamphetamine