[The role of inflammatory reaction in Alzheimer's disease and neurodegenerative processes].
Recent studies state that specific inflammatory mechanisms contribute to neurodegeneration. The theory is based on laboratory evidence of local upregulation of inflammatory cytokines (ex. IL-1, IL-6), acute phase proteins (ex. alpha 1-antitrypsin), activation of the complement cascade and accumulation of microglia in damaged regions in AD. In addition epidemiologic studies suggest that anti-inflammatory treatment provides some protection from AD. The first trials with prednisone fail to show any positive influence in AD patients. The alternative therapies are now considered with nonsteroid anti-inflammatory drugs, colchicine, cyclophosphamide. The anti-inflammatory treatment gives hope for slowing progression of the disease and decline of AD incidence.
Członkowska
Anna
A
Kurkowska-Jastrzebska
Iwona
I
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000544:Alzheimer Disease / Q000188:drug therapy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003167:Complement Activation; D016207:Cytokines / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D017628:Microglia / Q000473:pathology; D015854:Up-Regulation
D000209:Acute-Phase Proteins; D000893:Anti-Inflammatory Agents; D016207:Cytokines
Rola reakcji zapalnej w patogenezie choroby alzheimera i procesów neurodegeneracyjnych.