Total synthesis of ecteinascidin 743.
The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol-aldehyde cyclization, and acid-induced intramolecular sulfide formation.
Endo
Atsushi
A
Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, The Japan Science and Technology Cooperation (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Yanagisawa
Arata
A
Abe
Masanao
M
Tohma
Shigemitsu
S
Kan
Toshiyuki
T
Fukuyama
Tohru
T
D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis*; D004149:Dioxoles / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis*; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin
D018906:Antineoplastic Agents, Alkylating; D004149:Dioxoles; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin