title: The CTLA4 +49 A/G dimorphism is not associated with type 1 diabetes in Czech children.
abstract: We investigated the association of the CTLA4 +49 A/G dimorphism with type 1 diabetes in Czech children. Genotyping of 305 diabetic children and 289 controls by a novel PCR-ARMS assay revealed no significant differences in the genotypic or allelic frequencies. This may be another piece of evidence against the +49 A/G transition as the aetiological polymorphism within the CTLA4 gene.
authors.affiliation: 2nd Department of Paediatrics, 2nd Medical School, Charles University, Prague, Czech Republic. Ondrej.Cinek@Lfmotol.cuni.cz
authors.forename: O
authors.initials: O
authors.lastname: Cinek
authors.forename: P
authors.initials: P
authors.lastname: Drevínek
authors.forename: Z
authors.initials: Z
authors.lastname: Sumník
authors.forename: B
authors.initials: B
authors.lastname: Bendlová
authors.forename: S
authors.initials: S
authors.lastname: Kolousková
authors.forename: M
authors.initials: M
authors.lastname: Snajderová
authors.forename: J
authors.initials: J
authors.lastname: Vavrinec
mesh_terms: D000293:Adolescent; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics*; D060908:CTLA-4 Antigen; D016022:Case-Control Studies; D002648:Child; D018153:Czech Republic; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human