Hypopigmentation associated with an adenovirus-mediated gp100/MART-1-transduced dendritic cell vaccine for metastatic melanoma.
BACKGROUND
Reports of vitiligo associated with metastases and rare cases of spontaneous regression of disease have fueled enthusiasm for immunologic approaches to the treatment of advanced melanoma. More recent strategies have focused on using antigen-presenting dendritic cells as vaccines.


METHODS
We observed 3 cases of leukoderma associated with a novel adenovirus-mediated gp100/MART-1-transduced dendritic cell (MART indicates melanoma antigen recognized by T cells). All 3 patients had advanced metastatic melanoma. Despite the development of this leukodermic response, all patients experienced disease progression while under treatment.


CONCLUSIONS
We provide the initial evidence for effective induction of a leukodermic response with a gp100/MART-1-transduced dendritic cell vaccine.
Tsao
Hensin
H
Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA. htsao@partners.org
Millman
Peri
P
Linette
Gerald P
GP
Hodi
F Stephen
FS
Sober
Arthur J
AJ
Goldberg
Mark A
MA
Haluska
Frank G
FG
D000256:Adenoviridae / Q000235:genetics; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm; D001707:Biopsy, Needle; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017496:Hypopigmentation / Q000139:chemically induced* / Q000175:diagnosis; D058965:MART-1 Antigen; D008297:Male; D008545:Melanoma / Q000276:immunology / Q000473:pathology / Q000517:prevention & control* / Q000556:secondary; D008562:Membrane Glycoproteins / Q000008:administration & dosage / Q000009:adverse effects*; D009363:Neoplasm Proteins / Q000008:administration & dosage / Q000009:adverse effects*; D009367:Neoplasm Staging; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D058951:gp100 Melanoma Antigen
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D058965:MART-1 Antigen; C548667:MLANA protein, human; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; C548637:PMEL protein, human; D058951:gp100 Melanoma Antigen