title: Absorption and metabolism of antioxidative polyphenolic compounds in red wine.
abstract: We have shown that drinking red wine reduces oxidation of LDL. This reduction in oxidation has been attributed to the polyphenolic compounds in red wine, but the mechanisms of absorption and metabolism of these compounds has been unclear. We therefore investigated the absorption and metabolism of polyphenols using rats to identify their active forms in biological fluids. We also investigated the effect of tartaric acid (TA), a major organic acid in wine, on the absorption of polyphenols. Our results suggested that low molecular weight polyphenols are absorbed in the intestine and metabolized to their glucuronide conjugates, which exhibit antioxidative activity in plasma, and that TA can enhance the bioavailability of wine polyphenols.
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-cho, Hirakata City Osaka 573-0101, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Yamashita
authors.forename: Toshiyasu
authors.initials: T
authors.lastname: Sakane
authors.forename: Masami
authors.initials: M
authors.lastname: Harada
authors.forename: Namino
authors.initials: N
authors.lastname: Sugiura
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Koda
authors.forename: Yoshinabu
authors.initials: Y
authors.lastname: Kiso
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sezaki
mesh_terms: D000042:Absorption / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000493:pharmacokinetics*; D002392:Catechin / Q000378:metabolism / Q000493:pharmacokinetics; D005419:Flavonoids; D005707:Gallic Acid / Q000378:metabolism / Q000493:pharmacokinetics; D062385:Hydroxybenzoates / Q000378:metabolism / Q000493:pharmacokinetics; D008297:Male; D010636:Phenols / Q000378:metabolism* / Q000493:pharmacokinetics*; D011108:Polymers / Q000378:metabolism* / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013644:Tartrates / Q000494:pharmacology; D014920:Wine
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D062385:Hydroxybenzoates; D010636:Phenols; D011108:Polymers; D013644:Tartrates; C009091:protocatechuic acid; D005707:Gallic Acid; D002392:Catechin; C029768:tartaric acid