Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts.
The mouse is currently widely used as a model organism in the analysis of gene function but how developmentally regulated patterns of connexin gene expression in the mouse compare with those in the human is unclear. Here we compare the patterns of connexin expression in the heart during the development of the mouse (from embryonic day 12.5 to 6 weeks postpartum) and the human (at 9 weeks gestation and adult stage). The extent of connexin43 expression in the ventricles progressively increased during development of the mouse heart. The developmental pattern of expression for connexins 40 and 45 in the mouse heart was similar, but not identical, and in the ventricles showed a progressive and preferential expression in the conduction system. In general, these dynamic changes of connexins 43, 40 and 45 during mouse cardiac development appear to be mirrored in the human.
Kaba
R A
RA
Cardiac Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom. r.kaba@ic.ac.uk
Coppen
S R
SR
Dupont
E
E
Skepper
J N
JN
Elneil
S
S
Haw
M P
MP
Pepper
J R
JR
Yacoub
M H
MH
Rothery
S
S
Severs
N J
NJ
D000328:Adult; D000818:Animals; D018031:Connexin 43 / Q000378:metabolism*; D017630:Connexins / Q000378:metabolism*; D005136:Eye Proteins / Q000378:metabolism*; D005318:Fetal Heart / Q000378:metabolism; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D005865:Gestational Age; D006321:Heart / Q000196:embryology*; D006801:Humans; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D000097003:Gap Junction alpha-5 Protein; D000099264:Connexin 50
D018031:Connexin 43; D017630:Connexins; D005136:Eye Proteins; D000097003:Gap Junction alpha-5 Protein; D000099264:Connexin 50