title: Detection of porcine oleic acid-induced acute lung injury using pulmonary acoustics.
abstract: To evaluate the utility of monitoring the sound-filtering characteristics of the respiratory system in the assessment of acute lung injury (ALI), we injected a multifrequency broadband sound signal into the airway of five anesthetized, intubated pigs, while recording transmitted sound over the trachea and on the chest wall. Oleic acid injections effected a severe lung injury predominantly in the dependent lung regions, increasing venous admixture from 6 +/- 1 to 54 +/- 8% (P < 0.05) and reducing dynamic respiratory system compliance from 19 +/- 0 to 12 +/- 2 ml/cmH(2)O (P < 0.05). A two- to fivefold increase in sound transfer function amplitude was seen in the dependent (P < 0.05) and lateral (P < 0.05) lung regions; no change occurred in the nondependent areas. High within-subject correlations were found between the changes in dependent lung sound transmission and venous admixture (r = 0.82 +/- 0.07; range 0.74-0.90) and dynamic compliance (r = -0.87 +/- 0.05; -0.80 to -0.93). Our results indicate that the acoustic changes associated with oleic acid-induced lung injury allow monitoring of its severity and distribution.
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA. Rasanen.Jukka@mayo.edu
authors.forename: Jukka
authors.initials: J
authors.lastname: Räsänen
authors.forename: Noam
authors.initials: N
authors.lastname: Gavriely
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001784:Blood Gas Analysis; D006112:Gravitation; D006334:Heart Function Tests; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000503:physiopathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology; D019301:Oleic Acid / Q000633:toxicity*; D012129:Respiratory Function Tests; D013016:Sound; D013552:Swine
chemical_list: D019301:Oleic Acid