An attempt to predict a possible existence of antiviral and antimicrobial activity.
It is known that many pathogenic and toxic agents may attach to binding site of the same endogenic receptor. Such an effect is due to the resemblance between chemical structures in foreign agents. One may imagine the structure which contains binding-site fragments and may compete with the receptor for foreign agents. Then next suggestions are probable: (1)The same substance may interact with some agents with established resemblance; (2) If substance (1) interacts with agents A and B and substance (2) influences agent (2) only then (2) ought to act at agent B as well. In terms 'key-keyhole' this means an existence of the key fitting several keyholes. Application of this conception has given a possibility to predict an anti-HIV and antimicrobial activity of an antirabies immunoglobulin.
Danilenko
G I
GI
Institute of Organic Chemistry, National Academy of Science, Ukraine. iochkiev@ukrpack.net
D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000914:Antibodies, Viral / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D001665:Binding Sites; D006801:Humans; D008954:Models, Biological; D018716:Molecular Mimicry; D011820:Rabies virus / Q000276:immunology
D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D000914:Antibodies, Viral; D000998:Antiviral Agents