title: Effect of a lactose-containing sweetener on root dentine demineralization in situ.
abstract: Since lactose has been used as an excipient in powdered sweeteners, we evaluated its effect on dentine demineralization, in an in situ crossover study. Twelve adult volunteers wore palatal appliances containing 4 blocks of bovine root dentine, which were submitted 4 times a day to: distilled water (negative control), aqueous solution of powdered sweetener (Zero Cal); experimental group), 1.5% lactose solution (active group), 1.5% sucrose solution (positive control). After 15 days, microhardness was determined on dentine surface (SMH) and on the sectioned blocks (CSMH). All groups presented statistical differences in SMH before and after the treatments; water increased, while sweetener, lactose and sucrose decreased SMH. By CSMH, the only significant difference was observed after sucrose treatment. The data suggest that sweeteners containing lactose as a bulking agent may be cariogenic for root dentine.
authors.affiliation: Faculty of Dentistry of Piracicaba, State University of Campinas, Brazil.
authors.forename: C P
authors.initials: CP
authors.lastname: Aires
authors.forename: C P M
authors.initials: CP
authors.lastname: Tabchoury
authors.forename: A A
authors.initials: AA
authors.lastname: Del Bel Cury
authors.forename: J A
authors.initials: JA
authors.lastname: Cury
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000818:Animals; D001218:Aspartame / Q000494:pharmacology; D002326:Cariogenic Agents / Q000009:adverse effects; D002417:Cattle; D018592:Cross-Over Studies; D003804:Dentin / Q000187:drug effects*; D005079:Excipients; D006244:Hardness; D006801:Humans; D007785:Lactose / Q000009:adverse effects / Q000494:pharmacology*; D016037:Single-Blind Method; D013223:Statistics as Topic; D013395:Sucrose / Q000009:adverse effects; D013549:Sweetening Agents / Q000494:pharmacology*; D017001:Tooth Demineralization / Q000209:etiology* / Q000503:physiopathology; D014092:Tooth Root / Q000187:drug effects*; D014867:Water
chemical_list: D002326:Cariogenic Agents; D005079:Excipients; D013549:Sweetening Agents; D014867:Water; D013395:Sucrose; D007785:Lactose; D001218:Aspartame