title: In vitro antiplasmodial investigation of medicinal plants from El Salvador.
abstract: In vitro antiplasmodial activities of extracts from Albizia saman, Fabaceae, Calea tenuifolia (C. zacatechichi), Asteraceae, Hymenaea courbaril, Fabaceae, Jatropha curcas, Euphorbiaceae, Momordica charantia, Cucurbitaceae, and Moringa oleifera, Moringaceae were evaluated. From the lipophilic extract of C tenuifolia five active flavones were obtained. 4',5-Dihydroxy-7-methoxyflavone [genkwanin] and 5-hydroxy-4',7-dimethoxyflavone [apigenin 4',7-dimethylether] exhibited the strongest antiplasmodial activity against a chloroquine-sensitive strain (poW) and a chloroquine-resistant strain (Dd2) of Plasmodium falciparum [IC50 values: 17.1-28.5 microM). Furthermore octadeca-9,12-dienoic acid [linoleic acid] [IC50] values of 21.8 microM (poW) and 31.1 microM (Dd2)] and octadeca-9,12,15-trienoic acid (alpha-linolenic acid) were isolated.
authors.affiliation: Institut für Pharmazie, Freie Universität Berlin, Germany.
authors.forename: Inga
authors.initials: I
authors.lastname: Köhler
authors.forename: Kristina
authors.initials: K
authors.lastname: Jenett-Siems
authors.forename: Karsten
authors.initials: K
authors.lastname: Siems
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Hernández
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Ibarra
authors.forename: Walter G
authors.initials: WG
authors.lastname: Berendsohn
authors.forename: Ulrich
authors.initials: U
authors.lastname: Bienzle
authors.forename: Eckart
authors.initials: E
authors.lastname: Eich
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004544:El Salvador; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013045:Species Specificity
chemical_list: D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents