title: [In vitro study of chlorhexidine resistance in subgingival bacteria].
abstract: Chlorhexidine is an antibacterial agent of the bisguanide family. It's the most effectual molecule of all antiseptics for oral use. Because of its so frequent use, we have elaborated a protocol in order to estimate the resistance of the sub-gingival flora bacteria to its actions. We have determined the minimal inhibitory concentration of the different observed bacteria species and, have from that stage, progressively increased the concentration at a rate of 5 micrograms/ml. The obtained results show that the bacteria can undergo structural and/or biochemical alterations to adapt to more significant concentrations.
authors.affiliation: Département de parodontologie, Unité de Formation et recherche en odonto-stomatologie, l'Université d'Abidjan, Côte d'Ivoire.
authors.forename: A
authors.initials: A
authors.lastname: Kamagate
authors.forename: D
authors.initials: D
authors.lastname: Kone
authors.forename: N T
authors.initials: NT
authors.lastname: Coulibaly
authors.forename: E
authors.initials: E
authors.lastname: Brou
authors.forename: M
authors.initials: M
authors.lastname: Sixou
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000302:isolation & purification; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003773:Dental Plaque / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000891:Anti-Infective Agents, Local; C010882:chlorhexidine gluconate; D002710:Chlorhexidine
vernacular_title: Etude in vitro de la résistance à la chlorhexidine des bactéries de la flore sous-gingivale.