Induction of morphological alterations by antineoplastic agents in yeast.
Saccharomyces cerevisiae was used as an alternative experimental model in order to investigate the effects of antineoplastic agents on eukaryotic cells. After being exposed to the most common clinically used antineoplastic agents, yeast cells were examined under the light microscope. Folate and pyrimidine antagonists, platinum derivatives, mitomycin C, actinomycin D and bleomycin induced alterations in yeast cellular morphology, which were not observed following treatment with drugs belonging to any category other than the antineoplastics, leading to the suggestion that these alterations could potentially be used as an experimental tool in pre-screening for new chemotherapeutic leads.
Stavrinidis
E
E
Department of Experimental Pharmacology, Medical School, University of Athens, 11527 Athens, Greece.
Delitheos
A
A
Tiligada
E
E
D000970:Antineoplastic Agents / Q000145:classification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D009154:Mutation / Q000187:drug effects*; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics / Q000502:physiology
D000970:Antineoplastic Agents