Determination of irbesartan in the presence of hydrochlorothiazide by derivative spectrophotometry.
A first-derivative spectrophotometric method for the determination of irbesartan (IRB) alone and in the presence of hydrochlorothiazide (HCT) is described. Measurements are made at the zero-crossing wavelength at 263.0 nm for IRB. The calibration graph was linear over the range 1.0-12.0 mg l(-1) of IRB, detection limit was 0.15 mg l(-1). HCT, in the presence of IRB was determined by direct spectrophotometric method at 317 nm. The calibration graph was linear over the range 2.0-50.0 mg l(-1) of HCT, detection limit was 0.25 mg l(-1). The proposed methods were successfully applied to the determinations of IRB and HCT in combined tablets.
Albero
Isabel
I
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071 Murcia, Spain.
Ródenas
Vicente
V
García
Soledad
S
Sánchez-Pedreño
Concepción
C
D000959:Antihypertensive Agents / Q000032:analysis*; D001713:Biphenyl Compounds / Q000032:analysis*; D004347:Drug Interactions; D006852:Hydrochlorothiazide / Q000032:analysis*; D000077405:Irbesartan; D013053:Spectrophotometry / Q000379:methods*; D013607:Tablets; D013777:Tetrazoles / Q000032:analysis*
D000959:Antihypertensive Agents; D001713:Biphenyl Compounds; D013607:Tablets; D013777:Tetrazoles; D006852:Hydrochlorothiazide; D000077405:Irbesartan