[Effect of interleukin-1 on lymphocyte capacity of releasing factors affecting platelet adhesion and aggregation, blood coagulation and fibrinolysis].
Effects of recombinant interleukin-1 (IL-1) involved an inhibition of adhesion and thrombocyte aggregation. In heparinised blood, the IL-1 activates production of protein C (PnC), alpha 2-macroglobulin (alpha 2-MG) and alpha 1-antitrypsin (alpha 1-AT) and facilitates formation of the fibrinolysis inhibitors. In fibrinolysed blood, the IL-1 suppresses production of PnC, alpha 2-MG, alpha 1-AT, and inhibits the fibrinolysis. In a blood clot, the IL-1 suppresses production of PnC, alpha 2-MG, alpha 1-AT and activates the fibrinolysis.
Vitkovskiĭ
Iu A
IuA
Kuznik
B I
BI
D001685:Biological Factors / Q000378:metabolism*; D001777:Blood Coagulation; D005342:Fibrinolysis; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000494:pharmacology* / Q000502:physiology; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation
D001685:Biological Factors; D007375:Interleukin-1
Vliianie interleĭkina-1 na sposobnost' limfotsitov vydeliat' faktory, vliiaiushchie na adgeziiu i agregatsiiu trombotsitov, svertyvanie krovi i fibrinoliz.