title: Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells.
abstract: The epithelial component of the thymic microenvironment is indispensable for the generation of T lymphocytes. Although the heterogeneity of this epithelium is well documented, little is known about precursor-progeny relationships between distinct thymic epithelial lineages. Here we characterized a thymic epithelial cell subpopulation identified by the cell surface glycoprotein MTS24. These cells contained epithelial progenitor cells that were competent and sufficient to fully reconstitute the complex thymic epithelial microenvironment that supported normal T cell development.
authors.affiliation: Department of Pathology and Immunology, Monash University Medical School, Commercial Road, Prahran, Melbourne 3181, Australia. jason.gill@med.monash.edu.au
authors.forename: Jason
authors.initials: J
authors.lastname: Gill
authors.forename: Mark
authors.initials: M
authors.lastname: Malin
authors.forename: Georg A
authors.initials: GA
authors.lastname: Holländer
authors.forename: Richard
authors.initials: R
authors.lastname: Boyd
mesh_terms: D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation; D019070:Cell Lineage; D004268:DNA-Binding Proteins / Q000235:genetics; D005314:Embryonic and Fetal Development; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology; D005260:Female; D051858:Forkhead Transcription Factors; D015870:Gene Expression; D006411:Hematopoiesis, Extramedullary / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D018398:Homeodomain Proteins / Q000235:genetics; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D051761:Paired Box Transcription Factors; D019089:Stem Cell Factor / Q000235:genetics; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics
chemical_list: D015415:Biomarkers; D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; D018398:Homeodomain Proteins; C080331:Hoxa3 protein, mouse; D008562:Membrane Glycoproteins; D051761:Paired Box Transcription Factors; D019089:Stem Cell Factor; D014157:Transcription Factors; C090140:Whn protein; C070835:PAX1 transcription factor