Human cytomegalovirus infection and expression in human malignant glioma.
Malignant gliomas are the most common primary brain tumors in adults, have no known etiology, and are generally rapidly fatal despite current therapies. Human cytomegalovirus (HCMV) is beta-herpesvirus trophic for glial cells that persistently infects 50-90% of the adult human population. HCMV can be reactivated under conditions of inflammation and immunosuppression, and HCMV gene products can dysregulate multiple cellular pathways involved in oncogenesis. Here we show that a high percentage of malignant gliomas are infected by HCMV and multiple HCMV gene products are expressed in these tumors. These data are the first to show an association between HCMV and malignant gliomas and suggest that HCMV may play an active role in glioma pathogenesis.
Cobbs
Charles S
CS
Surgical Service, Veterans Affairs Medical Center, Birmingham, Alabama, USA. cscobbs@uabmc.edu
Harkins
Lualhati
L
Samanta
Minu
M
Gillespie
G Yancey
GY
Bharara
Suman
S
King
Peter H
PH
Nabors
L Burt
LB
Cobbs
C Glenn
CG
Britt
William J
WJ
D001254:Astrocytoma / Q000378:metabolism / Q000473:pathology / Q000821:virology; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D003587:Cytomegalovirus / Q000235:genetics* / Q000378:metabolism; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000378:metabolism; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D005814:Genes, Viral; D005910:Glioma / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D006801:Humans; D017874:Immediate-Early Proteins / Q000096:biosynthesis / Q000235:genetics; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008579:Meningioma / Q000378:metabolism / Q000473:pathology / Q000821:virology; D014764:Viral Proteins
D004279:DNA, Viral; C088645:IE1 protein, cytomegalovirus; D017874:Immediate-Early Proteins; D014764:Viral Proteins