Melanin-concentrating hormone and its receptors: state of the art.
Melanin-concentrating hormone (MCH) is a cyclic neuropeptide of nineteen amino acids in mammals. Its involvement in the feeding behaviour has been well established during the last few years. A first receptor subtype, now termed MCHIR, was discovered in 1999, following the desorphanisation of the SLCI orphan receptor, using either reverse pharmacology or systematic screening of agonist candidates. A second MCH receptor, MCH2R, has been discovered recently, by several groups working on data mining of genomic banks. The molecular pharmacology of these two receptors is only described on the basis of the action of peptides derived from MCH. The present review tentatively summarizes the knowledge on these two receptors and presents the first attempts to discover new classes of antagonists that might have major roles in the control of obesity and feeding behaviour.
Boutin
Jean A
JA
Division de Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, Croissy-sur-Seine, France. jean.boutin@fr.netgrs.com
Suply
Thomas
T
Audinot
Valérie
V
Rodriguez
Marianne
M
Beauverger
Philippe
P
Nicolas
Jean-Paul
JP
Galizzi
Jean-Pierre
JP
Fauchère
Jean-Luc
JL
D000595:Amino Acid Sequence / Q000502:physiology; D000818:Animals; D005247:Feeding Behavior / Q000502:physiology; D006801:Humans; D007028:Hypothalamic Hormones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008543:Melanins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D010907:Pituitary Hormones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011979:Receptors, Pituitary Hormone / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
D007028:Hypothalamic Hormones; D008543:Melanins; D010907:Pituitary Hormones; D011979:Receptors, Pituitary Hormone; C092274:melanin-concentrating hormone receptor; C019463:melanin-concentrating hormone