QUICKI is useful for following improvements in insulin sensitivity after therapy in patients with type 2 diabetes mellitus.
To investigate whether quantitative insulin sensitivity check index (QUICKI) would be useful as an index of insulin resistance during the clinical course of type 2 diabetes mellitus, correlation between QUICKI and the index of the euglycemic hyperinsulinemic clamp study [clamp insulin resistance (clamp IR)] was evaluated in 60 patients with type 2 diabetes mellitus before and after treatment. The therapy program consisted of diet (1440-1720 kcal/d) and exercise (walking 10,000 steps daily) for 6 wk. QUICKI and clamp IR were significantly correlated before (r = 0.598, P < 0.0001) and after (r = 0.583, P < 0.0001) treatment. Neither the slope nor the intercept of the linear correlation between QUICKI and clamp IR measured before treatment was significantly different from those measured after treatment (slopes; F = 0.002, P = 0.96, intercepts; F = 2.65, P = 0.11). During treatment, the values of both QUICKI (8% change; P < 0.0001) and clamp IR (38% change; P < 0.0001) significantly increased and their changes were significantly correlated (r = 0.415, P < 0.01). In conclusion, QUICKI may become a useful method for the follow-up of insulin resistance during the treatment of patients with type 2 diabetes mellitus.
Katsuki
Akira
A
Third Department of Internal Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. katuki-a@clin.medic.mie-u.ac.jp
Sumida
Yasuhiro
Y
Gabazza
Esteban C
EC
Murashima
Shuichi
S
Urakawa
Hideki
H
Morioka
Kohei
K
Kitagawa
Nagako
N
Tanaka
Takashi
T
Araki-Sasaki
Rika
R
Hori
Yasuko
Y
Nakatani
Kaname
K
Yano
Yutaka
Y
Adachi
Yukihiko
Y
D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000503:physiopathology* / Q000628:therapy; D004704:Endocrinology / Q000379:methods*; D005081:Exercise Therapy; D005260:Female; D005500:Follow-Up Studies; D015309:Glucose Clamp Technique; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged