Puberty in children with cancer.
Cancer may impinge on puberty either directly through a mass lesion effect on the reproductive axis or indirectly through hormones secreted by tumours, for example human chorionic gonadotrophin, or weight loss, or the actual presence of a chronic disease process per se. The more frequent pubertal problems faced by children with cancer are due to the impact of treatment either on the central nervous system, the hypothalamic-pituitary axis or the gonad; in this review, we concentrate on these complications and their potential management.
Shalet
Stephen M
SM
Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK. stephen.m.shalet@man.ac.uk
Brennan
Bernadette M D
BM
D000367:Age Factors; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000503:physiopathology* / Q000532:radiotherapy; D002648:Child; D016371:Cranial Irradiation / Q000009:adverse effects; D005260:Female; D006066:Gonads / Q000187:drug effects / Q000473:pathology; D020249:Hormone Replacement Therapy / Q000379:methods; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000503:physiopathology*; D011627:Puberty / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D013997:Time Factors