Stereocontrolled total synthesis of (-)-ebelactone A.
[structure: see text] The highly stereocontrolled hydroboration of an alkene, a subsequent Suzuki-Miyaura cross-coupling reaction, a silylcupration on a nonterminal acetylene, and an iododesilylation were the key steps in a convergent total synthesis of (-)-ebelactone A.
Mandal
Amit K
AK
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. akm33@cam.ac.uk
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D007783:Lactones; C030794:ebelactone A