title: Neosordarin and hydroxysordarin, two new antifungal agents from Sordaria araneosa.
abstract: Two novel antifungal agents belonging to the sordarin family have been isolated from fermentations of Sordaria araneosa by bioassay-guided purification and their structures elucidated by NMR techniques. Neosordarin (1) is closely related to the recently discovered hypoxysordarin (2), with only small differences on the aliphatic side chain acylating the hydroxyl in the 3'-position of the sordarose moiety. Hydroxysordarin (3) closely resembles sordarin (4), the only slight difference being the replacement of sordarose with altrose as the sugar unit.
authors.affiliation: Lehrbereich Biotechnologie der Universität, Kaiserslautern, Germany.
authors.forename: Paolo
authors.initials: P
authors.lastname: Davoli
authors.forename: Günther
authors.initials: G
authors.lastname: Engel
authors.forename: Andreas
authors.initials: A
authors.lastname: Werle
authors.forename: Olov
authors.initials: O
authors.lastname: Sterner
authors.forename: Timm
authors.initials: T
authors.lastname: Anke
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D003470:Culture Media; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D007192:Indenes; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests / Q000379:methods
chemical_list: D000935:Antifungal Agents; D003470:Culture Media; D007192:Indenes; C458899:hydroxysordarin; C458900:neosordarin