LEDGF, a survival factor, activates stress-related genes.
LEDGF is a survival factor and it enhances survival of various cell types against stress. LEDGF is also a transcriptional activator and it binds to promoter elements of heat shock and stress-related genes to activate expression of these genes. The elevated levels of the stress-related family of proteins, such as heat shock proteins, antioxidant proteins, and detoxication enzymes might suppress apoptosis induced by stress. The protective mechanisms against stress in mammalian cells and in yeast are surprisingly similar.
Shinohara
Toshimichi
T
Brigham and Women's Hospital, Department of Ophthalmology, Center for Ophthalmic Research, Harvard Medical School, Boston, MA 02115, USA. tshinohara@rics.bwh.harvard.edu
Singh
Dhirendra P
DP
Fatma
Nigar
N
D000818:Animals; D016923:Cell Death; D002470:Cell Survival / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D010786:Photoreceptor Cells / Q000502:physiology; D011401:Promoter Regions, Genetic; D017434:Protein Structure, Tertiary; D012164:Retinal Diseases / Q000503:physiopathology; D012441:Saccharomyces cerevisiae / Q000502:physiology; D013312:Stress, Physiological / Q000235:genetics* / Q000503:physiopathology; D014158:Transcription, Genetic
D036341:Intercellular Signaling Peptides and Proteins; C119380:lens epithelium-derived growth factor