Effects of ivermectin and albendazole against Anisakis simplex in vitro and in guinea pigs.
The activity of ivermectin and albendazole against larval Anisakis simplex was tested in vitro and in experimentally infected guinea pigs. Before drug exposure the medium for half of the larvae was adjusted to pH 2.0 with 1 N HCl, whereas the other half was held at pH 7.0. To these solutions, ivermectin was added to full concentrations of 1, 2, 5, 10, 50, 100, or 200 microg/ml, and for albendazole, 300, 400, and 500 microg/ml. Animals from group I were given 0.1 ml of 1% (3.3 mg/kg) ivermectin, whereas guinea pigs from group II were each given 5-7 mg (16.6-23.3 mg/kg) of albendazole orally. The efficacy of both drugs against L, A. simplex was high in vitro and in vivo against the larvae in different organs of guinea pigs.
Dziekońska-Rynko
Janina
J
Department of Parasitology, Warmia and Mazury University, Olsztyn, Poland. jdr@matman.uwm.edu.pl
Rokicki
Jerzy
J
Jablonowski
Zbigniew
Z
D015766:Albendazole / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D017129:Anisakiasis / Q000188:drug therapy*; D017163:Anisakis / Q000254:growth & development* / Q000378:metabolism; D000871:Anthelmintics / Q000494:pharmacology* / Q000627:therapeutic use; D004064:Digestive System / Q000469:parasitology; D006168:Guinea Pigs; D007559:Ivermectin / Q000494:pharmacology* / Q000627:therapeutic use
D000871:Anthelmintics; D007559:Ivermectin; D015766:Albendazole