Making ribosomes.
The past year has seen dramatic changes in our understanding of ribosome synthesis, fuelled largely by advances in proteomic analysis. It is now possible to outline the pathway of ribosome assembly, which is highly dynamic and involves a remarkable separation of the factors involved in the synthesis of the 40S and 60S ribosomal subunits. Around 140 identified, non-ribosomal proteins are currently implicated in post-transcriptional ribosome synthesis in yeast.
Fatica
Alessandro
A
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK.
Tollervey
David
D
D021581:Active Transport, Cell Nucleus; D006801:Humans; D046911:Macromolecular Substances; D008954:Models, Biological; D012323:RNA Processing, Post-Transcriptional; D012335:RNA, Ribosomal / Q000378:metabolism; D012269:Ribosomal Proteins / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism
D046911:Macromolecular Substances; D012335:RNA, Ribosomal; D012269:Ribosomal Proteins