title: [Effects of amrinone in patients undergoing off-pump coronary artery bypass grafting].
abstract: We evaluated the effect of amrinone in 41 patients undergoing off-pump coronary artery bypass grafting(CABG) retrospectively. Amrinone was intravenously administered at the rate of 5 mcg.kg-1.min-1 after coronary artery anastomosis (A 1 group: 11 cases) or after induction of anesthesia(A 2 group: 13 cases). The hemodynamic variables and use of concomitant drugs were compared among A 1, A 2 and the non-amrinone group (control group: 17 cases). Hemodynamics was measured before, during, after coronary artery anastomosis, and after the chest closure. Catecholamine and vasodilator were used to maintain mean arterial pressure (> 60 mmHg) and cardiac index(> 3.0 l.min-1.m-2). Mean pulmonary artery pressure, right atrial pressure and pulmonary artery wedge pressure were significantly higher during anastomosis than before anastomosis in control and A 1 group, but no significant changes in these parameters were observed in A 2 group. In addition, these variables increased significantly after chest closure in control group, but were unchanged in A 1 and A 2 groups. Patients with concomitant use of catecholamine and vasodilator in A 2 group were fewer than those in control and A 1 group. In conclusion, in the patients undergoing off-pump CABG, infusion of amrinone was recommended from the end of the induction of anesthesia.
authors.affiliation: Department of Anesthesiology, Nara Medical University, Kashihara 634-8522.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Sha
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimoda
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Matsunari
authors.forename: Masato
authors.initials: M
authors.lastname: Iwata
authors.forename: Toshinori
authors.initials: T
authors.lastname: Horiuchi
authors.forename: Naoko
authors.initials: N
authors.lastname: Kurita
authors.forename: Katsuyasu
authors.initials: K
authors.lastname: Kitaguchi
authors.forename: Katsuji
authors.initials: K
authors.lastname: Hirai
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Furuya
mesh_terms: D000368:Aged; D000676:Amrinone / Q000008:administration & dosage*; D002315:Cardiopulmonary Bypass; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D001026:Coronary Artery Bypass / Q000379:methods*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D002316:Cardiotonic Agents; D000676:Amrinone