Ganglioside reactive antibodies in the neuropathy associated with celiac disease.
We tested patients with celiac disease (CD) for the presence of serum anti-ganglioside antibodies. Six of twenty-seven patient sera were reactive against brain gangliosides by an agglutination immunoassay. Neurological examination in all six revealed the presence of distal sensory loss, consistent with the diagnosis of peripheral neuropathy. When tested by ELISA for antibodies to isolated GM1, GM2, GD1a, GD1b, GT1b, and GQ1b gangliosides, all six were positive for IgG antibodies to at least one. The neuropathy of celiac disease may be autoimmune and associated with anti-ganglioside antibodies. The presence of IgG reactivity furthermore implicates a T cell-mediated response to ganglioside antigens.
Alaedini
Armin
A
Department of Neurology and Neuroscience, Cornell University, 525 E. 68th St., LC-807, New York, NY 10021, USA. ara2004@med.cornell.edu
Green
Peter H R
PH
Sander
Howard W
HW
Hays
Arthur P
AP
Gamboa
Eugenia T
ET
Fasano
Alessio
A
Sonnenberg
Michelle
M
Lewis
Linda D
LD
Latov
Norman
N
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002446:Celiac Disease / Q000150:complications / Q000276:immunology*; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000276:immunology*
D001323:Autoantibodies; D005732:Gangliosides; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M