title: CD4 T-cell-mediated demyelination is increased in the absence of gamma interferon in mice infected with mouse hepatitis virus.
abstract: Mice infected with the murine coronavirus, mouse hepatitis virus, strain JHM (MHV) develop an immune-mediated demyelinating encephalomyelitis. Adoptive transfer of MHV-immune splenocytes depleted of either CD4 or CD8 T cells to infected mice deficient in recombination activation gene 1 resulted in demyelination. We showed previously that the process of CD8 T-cell-mediated demyelination was strongly dependent on the expression of gamma interferon (IFN-gamma) by donor cells. In this report, we show, in contrast, that demyelination and lymphocyte infiltration were increased in recipients of IFN-gamma(-/-) CD4 T cells when compared to levels in mice receiving C57BL/6 CD4 T cells.
authors.affiliation: Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Lecia
authors.initials: L
authors.lastname: Pewe
authors.forename: Jodie
authors.initials: J
authors.lastname: Haring
authors.forename: Stanley
authors.initials: S
authors.lastname: Perlman
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D020805:Central Nervous System Viral Diseases / Q000276:immunology / Q000503:physiopathology*; D018352:Coronavirus Infections / Q000276:immunology / Q000503:physiopathology*; D003711:Demyelinating Diseases / Q000276:immunology / Q000503:physiopathology*; D016654:Genes, RAG-1; D007371:Interferon-gamma / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D006517:Murine hepatitis virus / Q000472:pathogenicity*
chemical_list: D007371:Interferon-gamma