title: A novel ophthalmic presentation of the Proteus syndrome.
abstract: OBJECTIVE
  To report a patient with the Proteus syndrome who had ocular complications not previously described in the literature.
  
  
  METHODS
  Single observational case report.
  
  
  METHODS
  Retrospective review of the medical record and review of the literature.
  
  
  RESULTS
  The 26-year-old man has systemic features fulfilling the diagnostic criteria for the Proteus syndrome. His ocular abnormalities are myopia, mild calcific band keratopathy, cataract, abnormal vitreous structure, vitreous hemorrhage, a large chorioretinal mass, and a resolved serous retinal detachment.
  
  
  CONCLUSIONS
  Ocular complications are frequently reported in patients with the Proteus syndrome. Few of the patients reported in the literature have had comprehensive ocular examination by an ophthalmologist. Our patient is unique because he has been examined by ophthalmologists from childhood, and it is clear that the ocular findings may change with time. As far as we are aware, calcific band keratopathy, abnormal vitreous structure, and chorioretinal hamartoma associated with serous retinal detachment and vitreous hemorrhage have not previously been described.
authors.affiliation: Department of Ophthalmology, Addenbrooke's Hospital, Cambridge, England.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Sheard
authors.forename: F Michael
authors.initials: FM
authors.lastname: Pope
authors.forename: Martin P
authors.initials: MP
authors.lastname: Snead
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000175:diagnosis; D002386:Cataract / Q000175:diagnosis; D003316:Corneal Diseases / Q000175:diagnosis; D005124:Eye Abnormalities / Q000175:diagnosis*; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D009216:Myopia / Q000175:diagnosis; D016715:Proteus Syndrome / Q000175:diagnosis*; D012163:Retinal Detachment / Q000175:diagnosis; D012189:Retrospective Studies; D014823:Vitreous Hemorrhage / Q000175:diagnosis