title: The ultra-late phase of indocyanine green angiography for healthy subjects and patients with age-related macular degeneration.
abstract: OBJECTIVE
  To compare the characteristics of residual fundus fluorescence observed in the ultra-late phase of indocyanine green (ICG) angiography, in normal subjects and in patients with age-related macular degeneration (ARMD).
  
  
  METHODS
  ICG angiography was performed on 38 patients, 21 had ARMD, 9 were normal subjects aged >62, and 8 were normal subjects aged <36. The intensity and pattern of fluorescence from angiograms obtained in the ultra-late phase, 24 hours after dye injection, was also recorded and analyzed.
  
  
  RESULTS
  In the ultra-late phase, 95% of ARMD eyes with CNV showed geographic hypofluorescent lesions. All of the CNV that could be delineated with fluorescein and/or ICG angiography were located in these geographic lesions. In 73% of ARMD eyes without CNV, these hypofluorescent lesions occurred, while age-matched normal subjects had no hypofluorescent lesions. The mean intensity of fluorescence in the normal older subject group was significantly higher than that seen in the normal young subject group.
  
  
  CONCLUSIONS
  Increased fluorescence, associated with older subjects, in the ultra-late phase of ICG angiography may reflect aging changes in the chorioretinal complex. Geographic hypofluorescent areas, demonstrated only in the ultra-late phase, associate with ARMD and may represent areas predisposed to CNV development.
authors.affiliation: Department of Ophthalmology, Saitama Medical School, Saitama, Japan. keisuke@saitama-med.ac.jp
authors.forename: Keisuke
authors.initials: K
authors.lastname: Mori
authors.forename: Peter L
authors.initials: PL
authors.lastname: Gehlbach
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Deguchi
authors.forename: Shin
authors.initials: S
authors.lastname: Yoneya
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology; D016022:Case-Control Studies; D020256:Choroidal Neovascularization / Q000175:diagnosis; D004396:Coloring Agents; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D008268:Macular Degeneration / Q000175:diagnosis*; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green