Fibroblast growth factors in myocardial ischemia / reperfusion injury and ischemic preconditioning.
Angiogenic growth factors such as fibroblast growth factors (FGFs) are currently in clinical trials for accelerating blood vessel formation in myocardial and limb ischemic conditions. However, recent experimental evidence suggests that FGFs can also participate as endogenous cardioprotective agents. In this report, the current knowledge for FGFs implication in myocardial ischemic tolerance will be summarized. Pharmacologic preconditioning with drugs as FGFs that mimic the beneficial effects of ischemic preconditioning could lead to novel therapeutic approaches for the treatment of ischemic disorders including myocardial infarction and stroke.
Cuevas
P
P
Department of Research, Ramón y Cajal Hospital, Madrid, Spain. pedro.cuevas@hrc.es
Carceller
F
F
Giménez-Gallego
G
G
D000818:Animals; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D008954:Models, Biological; D009206:Myocardium / Q000473:pathology; D051381:Rats; D015427:Reperfusion Injury / Q000378:metabolism*
D005346:Fibroblast Growth Factors