Morphological differences between lens fibers in albino and pigmented rats.
The purpose of this study was to investigate the morphological characteristics of lens fibers in albino and pigmented rats by scanning electron microscopy. In addition to the ubiquitous interdigitating edge protrusions many ball-and-socket junctions were found on the lateral surfaces of lens fibers in pigmented rats. Notable differences in density, shape and size between superficial and deep cortical layers were observed. Especially, in the intermediate equatorial cortex large ball-and-socket junctions were found. In contrast, only few and small ball-and-socket junctions were observed in albino rats and many ruptures of lens fiber membranes were present in the anterior, superficial and intermediate equatorial cortex. The present observations show that different strains of rats have a different morphology of lens fibers. In view of a postulated role of ball-and-socket junctions in calcium homeostasis in the lens this may account for differences in cataractogenesis between albino and pigmented rats.
Yamada
Yoshihisa
Y
Lens and Cornea Research Unit, Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands. yoshihisay@yahoo.com
Willekens
Ben
B
Vrensen
Gijs F J M
GF
Wegener
Alfred
A
D016117:Albinism, Ocular / Q000473:pathology; D000818:Animals; D005260:Female; D007908:Lens, Crystalline / Q000648:ultrastructure*; D008855:Microscopy, Electron, Scanning; D051381:Rats; D011914:Rats, Inbred BN; D017207:Rats, Sprague-Dawley