[Bilateral acute retinal necrosis due to herpes simplex virus in inmunocompetent people and acyclovir resistance].
METHODS
A twenty-eight year old woman with necrotitizing retinitis and herpes simplex virus type 1 isolated in aqueous humor with polymerase chain reaction (PCR). An Acyclovir and corticosteroid therapy was started with unsuccessful response, Foscarnet was added getting quiescence of lesions.


CONCLUSIONS
Acute Retinal Necrosis Syndrome (ARNS), induced by a virus of the herpes family, could develop in immunocompetent people. A characteristic clinical case with uveitis and vitritis, white retinitis areas and occlusive vasculitis is reported. Antiviral therapy with acyclovir and antiinflammatory treatment must be established quickly. Foscarnet can effectively treat ARNS in inmunocompetent patients. In spite of therapy, this is a potentially blinding retinal disease.
Domingo Gordo
B
B
Departamento de Oftalmología, Hospital General Universitario Gregorio Marañón, Madrid, España. domingoblanca@hotmail.com
Luezas Morcuende
J J
JJ
Vidal Fernández
P
P
Aparicio Hernández-Lastras
M J
MJ
Suárez Leoz
M
M
D000208:Acute Disease; D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D017245:Foscarnet / Q000008:administration & dosage / Q000627:therapeutic use; D018259:Herpesvirus 1, Human / Q000302:isolation & purification; D006801:Humans; D016849:Keratitis, Herpetic / Q000150:complications* / Q000175:diagnosis; D009336:Necrosis; D016133:Polymerase Chain Reaction; D012160:Retina / Q000473:pathology; D012164:Retinal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D013997:Time Factors
D000998:Antiviral Agents; D017245:Foscarnet; D000212:Acyclovir
Necrosis retiniana aguda bilateral por herpes simple en individuo inmunocompetentes y resistencia a aciclovir.