title: Prothrombin G20210A mutation is not associated with recurrent miscarriages.
abstract: OBJECTIVE
  To assess the association between prothrombin G20210A mutation and recurrent miscarriages.
  
  
  METHODS
  A literature review was performed in Medline identifying articles from 1966 to December 2000. Articles meeting inclusion criteria were systematically reviewed and included in a meta-analysis.
  
  
  RESULTS
  Six trials, all case-controlled, were identified. These trials included 323 women with recurrent pregnancy loss. The odds ratio (OR) for heterozygous prothrombin mutation was 1.9 (95% confidence interval (CI) 0.98-4.14), and for homozygous prothrombin mutation was 3.76 (95% CI 0.75-18.77). The OR for prothrombin mutation and primary recurrent abortion was 2.19 (95% CI 0.61-7.89) and for prothrombin mutation and secondary recurrent abortion was 1.29 (95% CI 0.2-8.36).
  
  
  CONCLUSIONS
  There is no evidence to support an association of prothrombin G20210A mutation with recurrent miscarriages.
authors.affiliation: Department of Obstetrics and Gynaecology, Monash University, Victoria, Australia.
authors.forename: Chua Boon
authors.initials: CB
authors.lastname: Ghee
authors.forename: Robert F
authors.initials: RF
authors.lastname: Burrows
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D016017:Odds Ratio; D017354:Point Mutation; D011247:Pregnancy; D011516:Prothrombin / Q000235:genetics*; D012008:Recurrence; D018570:Risk Assessment; D014739:Victoria / Q000453:epidemiology
chemical_list: D011516:Prothrombin