title: Plasma-sprayed calcium phosphate particles with high bioactivity and their use in bioactive scaffolds.
abstract: Highly crystalline feedstock hydroxyapatite (HA) particles with irregular shapes were spheroidized by plasma spraying them onto the surface of ice blocks or into water. The spherical Ca-P particles thus produced contained various amounts of the amorphous phase which were controlled by the stand-off distance between the spray nozzle and the surface of ice blocks or waiter. The smooth surface morphology without cracks of spherical Ca-P particles indicated that there were very low thermal stresses in these particles. Plasma-sprayed Ca-P particles were highly bioactive due to their amorphous component and hence quickly induced the formation of bone-like apatite on their surfaces after they were immersed in an acellular simulated body fluid at 36.5 C. Bone-like apatite nucleated on dissolved surface (due to the amorphous phase) of individual Ca-P particles and grew to coalesce between neighboring Ca-P particles thus forming an integrated apatite plate. Bioactive and biodegradable composite scaffolds were produced by incorporating plasma-spray ed Ca-P particles into a degradable polymer. In vitro experiments showed that plasma-sprayed Ca-P particles enhanced the formation of bone-like apatite on the pore surface of Ca-P/PLLA composite scaffolds.
authors.affiliation: School of Mechanical and Production Engineering, Nanyang Technological University, Singapore.
authors.forename: Jie
authors.initials: J
authors.lastname: Weng
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Jiyong
authors.initials: J
authors.lastname: Chen
mesh_terms: D001672:Biocompatible Materials; D018786:Bone Substitutes / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D011091:Polyesters; D011108:Polymers / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D011091:Polyesters; D011108:Polymers; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D019344:Lactic Acid; C033616:poly(lactide); C485838:calcium phosphate, monobasic, anhydrous; D017886:Durapatite; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous