title: Napping predicts responsiveness to hypnotics in patients with primary circadian rhythm disorder.
abstract: It is hypothesized that one of the primary abnormalities of primary circadian rhythm disorder (PCRD) is the strong link between any episode of sleep and circadian rhythm. To test this hypothesis, the relationship between napping and responsiveness to hypnotics was examined in 12 patients with PCRD. A significant association was found (P = 0.04, chi2 test). Patients with PCRD who napped were all responders to hypnotics. The results suggest a strong link between episodes of sleep and circadian rhythm in some patients with PCRD, and might also suggest the heterogeneity of PCRD. Napping in patients with PCRD may be a predictor for responsiveness to hypnotics. In addition, napping and responsiveness to hypnotics might have a clinical value to differentiate PCRD from secondary CRD.
authors.affiliation: National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Japan. mchstr@ncnpmusachi.gr.jp
authors.forename: Toru
authors.initials: T
authors.lastname: Nakajima
authors.forename: Naofumi
authors.initials: N
authors.lastname: Kajimura
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kato
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Toru
authors.initials: T
authors.lastname: Hori
authors.forename: Kiyohisa
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D012890:Sleep / Q000502:physiology; D020178:Sleep Disorders, Circadian Rhythm / Q000188:drug therapy*; D012894:Sleep Stages / Q000187:drug effects*; D013997:Time Factors
chemical_list: D006993:Hypnotics and Sedatives