Analysis of risk factors for bacteremia in children with nontyphoidal Salmonella gastroenteritis.
To identify the risk factors for Salmonella bacteremia in infants and children with Salmonella gastroenteritis, a retrospective study of a 10-year period was conducted to evaluate 456 infants and children with culture-proven nontyphoidal Salmonella infection. Salmonella typhimurium was the most common isolate found. Among the 257 patients with gastroenteritis who had a concomitant blood culture performed, 50 exhibited bacteremia. Statistically significant differences were noted between patients with gastroenteritis and bacteremia and those without bacteremia in duration of fever > or = 5 days ( P < 0.001; OR, 5.6; 95% CI, 2.6 - 12.1) and infection with group D1 Salmonella ( P < 0.001; OR, 6.5; 95% CI, 2.5 - 16.9) after adjustment for multivariate analysis. Of the 320 Salmonella strains that were serotyped, Salmonella panama was shown to be strongly associated with bacteremia ( P<0.001) in children with gastroenteritis. In summary, in children with nontyphoidal Salmonella gastroenteritis, prolonged fever lasting 5 days or more and infection with a specific Salmonella serotype were risk factors closely associated with development of bacteremia.
Yang
Y-J
YJ
Department of Pediatrics, College of Medicine, National Cheng Kung University and Hospital 138, Sheng Li Road, Tainan 704, Taiwan.
Huang
M-C
MC
Wang
S-M
SM
Wu
J-J
JJ
Cheng
C-P
CP
Liu
C-C
CC
D000293:Adolescent; D016470:Bacteremia / Q000150:complications* / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000150:complications; D005759:Gastroenteritis / Q000150:complications* / Q000382:microbiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007958:Leukocyte Count; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D012475:Salmonella