Functional characteristics of cysteinyl-leukotriene receptor subtypes.
Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors, CysLT1 and CysLT2, have been cloned and functionally characterised using potent CysLT1 receptor antagonists and the dual CysLT1/CysLT2 receptor antagonist BAY u9773. However, the rank order of potency of the cysteinyl-leukotrienes at the CysLT receptors differs between tissues and studies, and a CysLT receptor classification based on agonist selectivity has not been established. In addition, the existence of more than two receptor subtypes for cysteinyl-leukotrienes has been suggested.
Bäck
Magnus
M
Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77, Stockholm, Sweden. Magnus.Back@imm.ki.se
D000818:Animals; D001249:Asthma / Q000628:therapy; D001808:Blood Vessels / Q000187:drug effects / Q000502:physiology; D003545:Cysteine / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D017998:Leukotriene D4 / Q000502:physiology; D015289:Leukotrienes / Q000494:pharmacology / Q000502:physiology*; D008565:Membrane Proteins; D018077:Receptors, Leukotriene / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D018836:Inflammation Mediators; D015289:Leukotrienes; D008565:Membrane Proteins; D018077:Receptors, Leukotriene; D014662:Vasoconstrictor Agents; C112381:cysteinyl-leukotriene; D017998:Leukotriene D4; C412375:cysteinyl leukotriene receptor 2; D003545:Cysteine; C083169:leukotriene D4 receptor