Diagnostic performance of arginase activity in colorectal cancer.
Arginase activity was measured in serum and biopsy from healthy individuals and colorectal cancer patients. Arginase activity in tumor samples (87 +/- 7.7 U/g tissue) was significantly higher than in controls (40.7 +/- 3.3 U/g tissue). However, serum arginase activity did not show any significant change in both groups. Finally, the micromethod used to quantify arginase activity in this study is superior to other methods because it has increased sensitivity, requires less sample, and is less time-consuming. Arginase differences are significant, according to the t-test (P<0.05)
del Ara
Rangel M
RM
Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain.
González-Polo
R A
RA
Caro
A
A
del Amo
E
E
Palomo
L
L
Hernández
E
E
Soler
G
G
Fuentes
J M
JM
D001119:Arginase / Q000097:blood*; D001681:Biological Assay; D014408:Biomarkers, Tumor; D001706:Biopsy; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D004795:Enzyme Stability; D006801:Humans; D012680:Sensitivity and Specificity; D014508:Urea / Q000378:metabolism
D014408:Biomarkers, Tumor; D014508:Urea; D001119:Arginase