title: Antithrombotic effect of onion in streptozotocin-induced diabetic rat.
abstract: In the present study, we investigated whether onion has antithrombotic effect in streptozotocin (STZ)-induced diabetic rats. In diabetic rats, serum thromboxane B(2) (TXB(2)) level was elevated compared to that in normal, and this elevation in diabetes was significantly inhibited by treatment with onion (0.5 g/ml/kg/day, i.p.) for 4 weeks. In normal rats, the serum TXB(2) level remained unaltered after the treatment with onion. To investigate in vitro effect of onion, we examined its effect on TXB(2) formation, platelet aggregation and arachidonic acid (AA)-release in platelets from diabetic and normal rats. Onion showed a significant inhibitory effect on collagen- or AA-induced TXB(2) formation with greater potency in diabetic platelets than in normal. Similarly, more potent inhibitory effects of onion in diabetes were observed in collagen- or AA-induced platelet aggregation and collagen-induced AA release response. In conclusion, these results suggest that onion can produce more beneficial antithrombotic effect in diabetes.
authors.affiliation: Department of Physiology, School of Medicine, Ajou University, Paldal-gu, Suwon, South Korea.
authors.forename: Yi-Sook
authors.initials: YS
authors.lastname: Jung
authors.forename: Min Hwa
authors.initials: MH
authors.lastname: Kim
authors.forename: Soo Hwan
authors.initials: SH
authors.lastname: Lee
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Baik
authors.forename: Se Won
authors.initials: SW
authors.lastname: Park
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Moon
mesh_terms: D000818:Animals; D000991:Antithrombins / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D019697:Onions; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000494:pharmacology; D013929:Thromboxane B2 / Q000096:biosynthesis / Q000097:blood
chemical_list: D000991:Antithrombins; D001095:Arachidonic Acids; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D013929:Thromboxane B2; D013311:Streptozocin; D007770:L-Lactate Dehydrogenase