title: Asymmetric synthesis of syn- and anti-1,3-amino alcohols.
abstract: The first application of metalloenamines derived from N-sulfinyl imines is reported for the highly diastereoselective addition to aldehydes. Reduction of the beta-hydroxy-N-sulfinyl imine products with catecholborane and LiBHEt3 provides syn- and anti-1,3-amino alcohol derivatives, respectively, with very high diastereomeric ratios.
authors.affiliation: Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, California 94720, USA.
authors.forename: Takuya
authors.initials: T
authors.lastname: Kochi
authors.forename: Tony P
authors.initials: TP
authors.lastname: Tang
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Ellman
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000605:Amino Alcohols