Mouse models of prostate carcinogenesis.
In recent years, numerous mouse models have been generated that recapitulate salient features of prostate carcinogenesis in humans. Here we review progress in the generation and validation of mouse models for prostate cancer, discuss current limitations of these models, and highlight directions of future research.
Abate-Shen
Cory
C
Center for Advanced Biotechnology and Medicine, Department of Neuroscience, UMDNJ-Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA. abate@cabm.rutgers.edu
Shen
Michael M
MM
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009857:Oncogenes; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D013539:Simian virus 40 / Q000235:genetics