title: Diagnostic performance of arginase activity in colorectal cancer.
abstract: Arginase activity was measured in serum and biopsy from healthy individuals and colorectal cancer patients. Arginase activity in tumor samples (87 +/- 7.7 U/g tissue) was significantly higher than in controls (40.7 +/- 3.3 U/g tissue). However, serum arginase activity did not show any significant change in both groups. Finally, the micromethod used to quantify arginase activity in this study is superior to other methods because it has increased sensitivity, requires less sample, and is less time-consuming. Arginase differences are significant, according to the t-test (P<0.05)
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain.
authors.forename: Rangel M
authors.initials: RM
authors.lastname: del Ara
authors.forename: R A
authors.initials: RA
authors.lastname: González-Polo
authors.forename: A
authors.initials: A
authors.lastname: Caro
authors.forename: E
authors.initials: E
authors.lastname: del Amo
authors.forename: L
authors.initials: L
authors.lastname: Palomo
authors.forename: E
authors.initials: E
authors.lastname: Hernández
authors.forename: G
authors.initials: G
authors.lastname: Soler
authors.forename: J M
authors.initials: JM
authors.lastname: Fuentes
mesh_terms: D001119:Arginase / Q000097:blood*; D001681:Biological Assay; D014408:Biomarkers, Tumor; D001706:Biopsy; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D004795:Enzyme Stability; D006801:Humans; D012680:Sensitivity and Specificity; D014508:Urea / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D014508:Urea; D001119:Arginase