New taxane diterpenoids from the roots of Taiwanese Taxus mairei.
Five new taxane diterpenoids, taxumairols G (1), H (2), I (3), J (4), and L (5) were isolated from extracts of the roots of Taiwanese Taxus mairei (LEMEE & LEVL.) S. Y. Hu. Compounds 1-4 belong to the new 11(15-->1)-abeo-taxene system, having a tetrahydrofuran ring along carbons C-2, C-3, C-4 and C-20. Compounds 3 and 4 contain an isopropenyl group at C-1 while compounds 1 and 2 are attached with a benzoxyl group at C-15. The structures of compounds 1-5 were determined on the basis of two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear Overhauser effect spectroscopy (NOESY) experiments.
Shen
Ya-Ching
YC
Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China. ycshen@mail.nsysu.edu
Chang
Yao-To
YT
Lin
Yu-Chi
YC
Lin
Chung-Ling
CL
Kuo
Yao-Haur
YH
Chen
Ching-Yeu
CY
D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000302:isolation & purification*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D018517:Plant Roots / Q000737:chemistry; D013624:Taiwan; D043823:Taxoids; D020946:Taxus / Q000737:chemistry*
D001952:Bridged-Ring Compounds; D004224:Diterpenes; D043823:Taxoids; C464602:taxumairol G; C464601:taxumairol H; C464600:taxumairol I; C080625:taxane