title: Hemicraniectomy and moderate hypothermia in patients with severe ischemic stroke.
abstract: OBJECTIVE
  We compared the clinical course of 36 consecutive patients with severe acute ischemic stroke (more than two thirds of the middle cerebral artery territory) treated with hemicraniectomy (CE; n=17) or moderate hypothermia (MH; n=19) in terms of intracranial pressure control, mortality, and specific treatment parameters.
  
  
  METHODS
  Over a period of 18 months, patients with severe ischemic stroke were treated with CE when the nondominant hemisphere was affected and with MH when the dominant hemisphere was affected. MH (33 degrees C) was induced with either cold blankets and fans (n=11) or endovascular cooling (n=8). Intracranial pressure was monitored invasively in all cases.
  
  
  RESULTS
  Age, sex, cranial CT findings, level of consciousness, and time to treatment were similar between the 2 groups; significant differences were noted in National Institute of Health Stroke Scale (NIHSS) score (20 [range, 18 to 22] and 17 [range, 16 to 18] for MH and CE, respectively) but were not present when NIHSS score was corrected for aphasia (17 [range, 15 to 19] and 17 [range, 16 to 18] for MH and CE, respectively). Mortality was 12% for CE and 47% for MH; 1 patient treated with MH died as a result of treatment complications (sepsis) and 3 of intracranial pressure crises that occurred during rewarming. Duration of mechanical ventilation and of neurological intensive care unit stay did not significantly differ, but duration of catecholamine application and maximal catecholamine dosage were significantly higher in the MH group.
  
  
  CONCLUSIONS
  In patients with severe ischemic stroke, CE results in lower mortality and lower complication rates compared with MH. Both treatment modalities, however, are associated with intensive medical treatment and a prolonged stay in the neurological intensive care unit.
authors.affiliation: Department of Neurology, University of Heidelberg, Heidelberg, Germany. Dimitrios.Georgiadis@nos.usz.ch
authors.forename: D
authors.initials: D
authors.lastname: Georgiadis
authors.forename: S
authors.initials: S
authors.lastname: Schwarz
authors.forename: A
authors.initials: A
authors.lastname: Aschoff
authors.forename: S
authors.initials: S
authors.lastname: Schwab
mesh_terms: D000328:Adult; D000368:Aged; D001831:Body Temperature; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D002544:Cerebral Infarction / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D003399:Craniotomy / Q000009:adverse effects; D019299:Decompression, Surgical / Q000009:adverse effects; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D007427:Intracranial Pressure; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome