title: Hugh E. Huxley: birth of the filament sliding model of muscle contraction.
abstract: Hugh E. Huxley used a combination of X-ray diffraction and electron microscopy to define the structural basis for muscle contraction. He developed the entirely new concept of movement based on the relative motion of two elongated protein polymers powered by the action of independent molecular motors. The concept applies to a large number of cell motility mechanisms.
authors.affiliation: Dept of Biochemistry, University of Pennsylvania, Philadelphia 19104, USA. amweber@mail.med.upenn.edu
authors.forename: Annemarie
authors.initials: A
authors.lastname: Weber
authors.forename: Clara
authors.initials: C
authors.lastname: Franzini-Armstrong
mesh_terms: D000818:Animals; D002465:Cell Movement; D049673:History, 20th Century; D006801:Humans; D009119:Muscle Contraction; D010827:Physiology / Q000266:history; D006113:United Kingdom