title: Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome.
abstract: An association between ischemic stroke and increased oxidative stress has been suggested from animal studies. However, there is a lack of evidence with respect to this association in humans. Here, the time course of plasma levels of six carotenoids, which are lipophilic micronutrients with antioxidant properties, as well as of malondialdehyde (MDA), a marker of lipid peroxidation, was followed in ischemic stroke patients. Plasma levels of lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha- and beta-carotene, as well as MDA were measured by high-performance liquid chromatography in 28 subjects (19 men and nine women aged 76.9+/-8.7 years) with an acute ischemic stroke of recent onset (<24h) on admission, after 6 and 24 h, and on days 3, 5, and 7. Carotenoid and MDA levels in patients on admission were compared with those of age- and sex-matched controls. Plasma levels of lutein, lycopene, alpha- and beta-carotene were significantly lower and levels of MDA were significantly higher in patients in comparison with controls. Significantly higher levels of MDA and lower levels of lutein were found in patients with a poor early-outcome (functional decline) after ischemic stroke as compared to patients who remained functionally stable. These findings suggest that the majority of plasma carotenoids are lowered immediately after an ischemic stroke, perhaps as a result of increased oxidative stress, as indicated by a concomitant rise in MDA concentrations. Among the carotenoids, only lutein plasma changes are associated with a poor early-outcome.
authors.affiliation: Institute of Physiological Chemistry I, Heinrich-Heine University, Düsseldorf, Germany. polidori@uni-duesseldorf.de
authors.forename: M Cristina
authors.initials: MC
authors.lastname: Polidori
authors.forename: Antonio
authors.initials: A
authors.lastname: Cherubini
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Stahl
authors.forename: Umberto
authors.initials: U
authors.lastname: Senin
authors.forename: Helmut
authors.initials: H
authors.lastname: Sies
authors.forename: Patrizia
authors.initials: P
authors.lastname: Mecocci
mesh_terms: D000368:Aged; D001205:Ascorbic Acid / Q000097:blood; D002545:Brain Ischemia / Q000097:blood*; D002338:Carotenoids / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D018450:Disease Progression; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D014975:Lutein / Q000097:blood; D000077276:Lycopene; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress; D020521:Stroke / Q000097:blood*; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood; D024341:Xanthophylls; D065146:Zeaxanthins; D019207:beta Carotene / Q000031:analogs & derivatives / Q000097:blood
chemical_list: D024341:Xanthophylls; D065146:Zeaxanthins; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D002338:Carotenoids; D008315:Malondialdehyde; D001205:Ascorbic Acid; D000077276:Lycopene; D014975:Lutein