Phospholipids reduce adhesion formation in the rabbit uterine horn model.
OBJECTIVE
To access the ability of intraperitoneal phospholipids to reduce adhesions in a standardized model for gynecologic operations.


METHODS
A randomized, experimental, blinded study using the double uterine horn model.


METHODS
Academic animal research laboratory.


METHODS
Thirty-three Chinchilla rabbits.


METHODS
Phospholipids or Ringer's lactate were intraperitoneally administered after bilateral uterine horn injury.


METHODS
After 10 days, adhesions were evaluated concerning area and strength as well as scores describing tenacity and degree.


RESULTS
Phospholipids (median 102.1 mm2) significantly reduce adhesion areas in comparison to surgical controls (median 392.2 mm2) and Ringer group (median 323.8 mm2). Scores reflecting severity and degree of adhesions support this finding.


CONCLUSIONS
These results prove the efficacy of phospholipids in the double uterine horn model. Future clinical studies are recommended.
Müller
Stefan A
SA
Department of Surgery, Medical Faculty, Rhenish-Westphalian Technical University, Aachen, Germany. sa.mueller@chir.rwth-aachen.de
Treutner
Karl H
KH
Jörn
Hendrik
H
Anurov
Michail
M
Oettinger
Alexander P
AP
Schumpelick
Volker
V
D000818:Animals; D005260:Female; D007274:Injections, Intraperitoneal; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D010743:Phospholipids / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D000077325:Ringer's Lactate; D012720:Severity of Illness Index; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control; D014591:Uterine Diseases / Q000473:pathology / Q000517:prevention & control*
D007552:Isotonic Solutions; D010743:Phospholipids; D000077325:Ringer's Lactate