title: Thrombotic microangiopathies.
abstract: The thrombotic microangiopathies (TMA) are a group of diseases associated with microangiopathic hemolytic anemia, thrombocytopenia, and end-organ dysfunction. These seemingly disparate entities share in common a pathogenic mechanism involving endothelial injury and thrombus formation. Prognosis and treatment depend on the nature of the underlying disease.
authors.affiliation: Division of Nephrology, Department of Medicine, Columbia-Presbyterian Medical Center, New York, NY, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Halevy
authors.forename: Jai
authors.initials: J
authors.lastname: Radhakrishnan
authors.forename: Glen
authors.initials: G
authors.lastname: Markowitz
authors.forename: Gerald
authors.initials: G
authors.lastname: Appel
mesh_terms: D000743:Anemia, Hemolytic / Q000150:complications / Q000209:etiology / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000473:pathology; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology; D008833:Microcirculation; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology; D012595:Scleroderma, Systemic / Q000209:etiology; D013921:Thrombocytopenia / Q000150:complications / Q000209:etiology / Q000503:physiopathology; D013927:Thrombosis / Q000150:complications / Q000209:etiology / Q000503:physiopathology