Daily infusion of melatonin entrains circadian activity rhythms in the diurnal rodent Arvicanthis ansorgei.
The effect of exogenous melatonin (MEL) on the circadian system in nocturnal species has been extensively studied, but little is known about its chronobiotic effect in diurnal mammals. The present study investigated the effect of exogenous MEL on the circadian locomotor activity rhythm in the diurnal rodent Arvicanthis ansorgei. Male animals (n=34) were fitted with a subcutaneous catheter for daily infusion of MEL (1 h; 100 microg) and their running wheel activity was recorded. The results showed that administration of MEL to animals free-running in DD entrained their activity rhythm by phase advances at circadian time (CT) 10.62, and by phase delays at CT -0.40 (CT 0, activity onset). The range of entrainment was 17 and 11.5 min for advance and delay stimuli, respectively. Interestingly, in the nocturnal rat and the A. ansorgei, entrainment of the activity rhythm to exogenous MEL by phase advances occurs at exactly the same phase of the circadian cycle. In both nocturnal and diurnal species, the sensitivity window for exogenous MEL is located near the activity/rest transition points. It is concluded that the functional properties of entrainment to exogenous MEL are similar to those of other nonphotic stimuli. Furthermore, A. ansorgei might be an interesting animal model for studies on the chronobiotic effects of exogenous MEL in diurnal mammals including humans.
Slotten
Helge A
HA
ULP UMR-CNRS 7518, Lab de Neurobiologie des Fonctions Rythmiques et Saisonnières, Université Louis Pasteur, 12 rue de l'Université, FR-67000 Strasbourg, France.
Krekling
Sturla
S
Sicard
Bruno
B
Pévet
Paul
P
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology*; D007262:Infusions, Intravenous; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D009115:Muridae / Q000502:physiology*
D008550:Melatonin