Total synthesis of pyridovericin: studies toward the biomimetic synthesis of pyridomacrolidin.
[reaction: see text] The total synthesis of the novel metabolite pyridovericin 1 is reported. The synthesis of this key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2 has been accomplished in good yield from readily available 2,4-dihydroxypyridine.
Baldwin
Jack E
JE
Dyson Perrins Laboratory, Oxford University, South Parks Road, Oxford OX1 3QY, UK. jack.baldwin@chem.ox.ac.uk
Adlington
Robert M
RM
Conte
Aurelia
A
Irlapati
Nageswara Rao
NR
Marquez
Rodolfo
R
Pritchard
Gareth J
GJ
D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D005658:Fungi / Q000737:chemistry; D018716:Molecular Mimicry; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry
D004791:Enzyme Inhibitors; D011728:Pyridones; C114117:pyridomacrolidin; C114116:pyridovericin; D011505:Protein-Tyrosine Kinases