Outside and in: development of neuronal excitability.
Investigation of the development of excitability has revealed that cells are often specialized at early stages to generate Ca(2+) transients. Studies of excitability have converged on the central role of Ca(2+) and K(+) channels in the plasmalemma that regulate Ca(2+) influx and have identified critical functions for receptor-activated channels in the endoplasmic reticulum that allow efflux of Ca(2+) from intracellular stores. The parallels between excitability in these two locations motivate future work, because comparison of their properties identifies shared attributes.
Spitzer
Nicholas C
NC
Neurobiology Section 0357, Biology Division, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0357, USA.
Kingston
Paul A
PA
Manning
Timothy J
TJ
Conklin
Matthew W
MW
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D015222:Sodium Channels / Q000378:metabolism / Q000502:physiology
D015220:Calcium Channels; D015222:Sodium Channels