title: Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
abstract: The hematopathology subcommittee of the Mouse Models of Human Cancers Consortium recognized the need for a classification of murine hematopoietic neoplasms that would allow investigators to diagnose lesions as well-defined entities according to accepted criteria. Pathologists and investigators worked cooperatively to develop proposals for the classification of lymphoid and nonlymphoid hematopoietic neoplasms. It is proposed here that nonlymphoid hematopoietic neoplasms of mice be classified in 4 broad categories: nonlymphoid leukemias, nonlymphoid hematopoietic sarcomas, myeloid dysplasias, and myeloid proliferations (nonreactive). Criteria for diagnosis and subclassification of these lesions include peripheral blood findings, cytologic features of hematopoietic tissues, histopathology, immunophenotyping, genetic features, and clinical course. Differences between murine and human lesions are reflected in the terminology and methods used for classification. This classification will be of particular value to investigators seeking to develop, use, and communicate about mouse models of human hematopoietic neoplasms.
authors.affiliation: Comprehensive Cancer Center and Department of Laboratory Medicine, University of California, San Francisco, 94143, USA. skogan@cc.ucsf.edu
authors.forename: Scott C
authors.initials: SC
authors.lastname: Kogan
authors.forename: Jerrold M
authors.initials: JM
authors.lastname: Ward
authors.forename: Miriam R
authors.initials: MR
authors.lastname: Anver
authors.forename: Jules J
authors.initials: JJ
authors.lastname: Berman
authors.forename: Cory
authors.initials: C
authors.lastname: Brayton
authors.forename: Robert D
authors.initials: RD
authors.lastname: Cardiff
authors.forename: John S
authors.initials: JS
authors.lastname: Carter
authors.forename: Sherri
authors.initials: S
authors.lastname: de Coronado
authors.forename: James R
authors.initials: JR
authors.lastname: Downing
authors.forename: Torgny N
authors.initials: TN
authors.lastname: Fredrickson
authors.forename: Diana C
authors.initials: DC
authors.lastname: Haines
authors.forename: Alan W
authors.initials: AW
authors.lastname: Harris
authors.forename: Nancy Lee
authors.initials: NL
authors.lastname: Harris
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hiai
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Jaffe
authors.forename: Ian C M
authors.initials: IC
authors.lastname: MacLennan
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Pandolfi
authors.forename: Paul K
authors.initials: PK
authors.lastname: Pattengale
authors.forename: Archibald S
authors.initials: AS
authors.lastname: Perkins
authors.forename: R Mark
authors.initials: RM
authors.lastname: Simpson
authors.forename: Mark S
authors.initials: MS
authors.lastname: Tuttle
authors.forename: Joanne F
authors.initials: JF
authors.lastname: Wong
authors.forename: Herbert C
authors.initials: HC
authors.lastname: Morse
mesh_terms: D000818:Animals; D019337:Hematologic Neoplasms / Q000145:classification* / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000145:classification / Q000473:pathology; D051379:Mice; D009196:Myeloproliferative Disorders / Q000145:classification / Q000473:pathology; D009316:National Institutes of Health (U.S.); D009436:Neural Tube Defects / Q000145:classification / Q000473:pathology; D012509:Sarcoma / Q000145:classification / Q000473:pathology; D014481:United States