title: Preoperative chemoradiation in patients with resectable rectal cancer: results on tumor response.
abstract: BACKGROUND
  There is no consensus about the role of preoperative radiotherapy (RT) and chemotherapy (CT) in patients with resectable cancer of the distal rectum. This study analyzed the local clinical and pathologic response in patients receiving preoperative RT/CT for rectal cancer.
  
  
  METHODS
  Thirty-two consecutive patients with a palpable adenocarcinoma of the rectum received preoperative RT (45 Gy in 25 fractions over 5 weeks) plus continuous chemotherapy with doxifluridine and leucovorin or 5-fluorouracil by continuous intravenous infusion during RT. Surgery was performed 8 weeks later. The Wilcoxon and chi(2) tests were used for data analysis.
  
  
  RESULTS
  Twelve patients had mild gastrointestinal toxicity, only one of whom required interruption of therapy. The tumor shrank to 57.8% of its original size, and at the echoendoscopy (u) there was a 58.7% decrease of the maximum diameter (P <.001). Downstaging from uT3 and uT2 to <uT3 and <uT2, respectively, occurred in 41.6% of patients (P =.0020). Total and major regression of the tumor at the histopathologic examination occurred in 12.5% and 50% of patients.
  
  
  CONCLUSIONS
  Local response to preoperative RT/CT was highly satisfactory and allowed conservative surgery in 81% of patients. Optimization of the combined therapy could achieve even better results.
authors.affiliation: Departments of Surgical Oncology I, Istituto Nazionale per lo Studio e la Cura dei Tumori (National Cancer Institute), Via Venezian, I-20133 Milan, Italy. dottfb@tin.it
authors.forename: Federico
authors.initials: F
authors.lastname: Bozzetti
authors.forename: Salvatore
authors.initials: S
authors.lastname: Andreola
authors.forename: Dario
authors.initials: D
authors.lastname: Baratti
authors.forename: Luigi
authors.initials: L
authors.lastname: Mariani
authors.forename: Simonetta C
authors.initials: SC
authors.lastname: Stani
authors.forename: Francesca
authors.initials: F
authors.lastname: Valvo
authors.forename: Pasquale
authors.initials: P
authors.lastname: Spinelli
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D005467:Floxuridine; D002955:Leucovorin; D005472:Fluorouracil; C025034:doxifluridine