[Cushing's disease in children and adolescents].
Fifty-seven unselected children and adolescents with Cushing's disease underwent transsphenoidal exploration and microadenomectomy before their 16th birthday. Hypercortisolism was corrected in 42 of the 57 patients (74%). The recurrence rate was 17% and the long-term remission rate was 57%. Diagnostic peculiarities specific surgical problems and outcome were reviewed. Direct transnasal submucosal surgery for Cushing's disease is successful, and pituitary function can be preserved in most of these young patients.
Linglart
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Service d'Endocrinologie Pédiatrique, Hôpital Saint-Vincent-de-Paul, Paris, France.
Visot
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D000182:ACTH Syndrome, Ectopic / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D000236:Adenoma / Q000150:complications / Q000453:epidemiology* / Q000378:metabolism / Q000601:surgery; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D003480:Cushing Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery; D003952:Diagnostic Imaging; D004393:Dwarfism, Pituitary / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007016:Hypophysectomy; D007018:Hypopituitarism / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008866:Microsurgery; D009364:Neoplasm Recurrence, Local; D010297:Paris / Q000453:epidemiology; D010911:Pituitary Neoplasms / Q000150:complications / Q000453:epidemiology* / Q000378:metabolism / Q000601:surgery; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D012074:Remission Induction; D012189:Retrospective Studies; D012306:Risk; D016896:Treatment Outcome
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
La maladie de Cushing chez l'enfant et l'adolescent.