Mechanisms of chromosome-end protection.
Telomeres must protect chromosome ends from being recognized and processed as double-strand breaks. Identification of the factors involved in end protection, and the mechanisms by which they "cap" chromosome termini, is crucial in understanding how the cell distinguishes between a double-strand break and a normal telomere end. Recent work has characterized the similarities and potential differences between the pathways utilized by multiple organisms in maintaining telomere ends. One unifying concept that has clearly emerged is that chromosome-end protection is necessary in maintaining genetic stability and preventing oncogenesis.
Cervantes
Rachel B
RB
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Lundblad
Victoria
V
D034961:Antigens, Nuclear; D015825:Chromosomes, Fungal; D002877:Chromosomes, Human; D004265:DNA Helicases; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000502:physiology; D006801:Humans; D000072200:Ku Autoantigen; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000502:physiology; D004718:Saccharomycetales / Q000235:genetics; D016615:Telomere / Q000235:genetics*
D034961:Antigens, Nuclear; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D004265:DNA Helicases; C106893:XRCC5 protein, human; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen