title: Antimalarial activities of ring-substituted bioimidazoles.
abstract: We report in vitro antimalarial activities against chloroquine sensitive and resistant Plasmodium falciparum strains, and in vivo activities against Plasmodium berghei in mice for four series of ring-substituted-L-histidines and histamines.
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062, India. rahuljain@mailmetoday.com
authors.forename: Rahul
authors.initials: R
authors.lastname: Jain
authors.forename: Suryanarayana
authors.initials: S
authors.lastname: Vangapandu
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Jain
authors.forename: Navneet
authors.initials: N
authors.lastname: Kaur
authors.forename: Savita
authors.initials: S
authors.lastname: Singh
authors.forename: Prati Pal
authors.initials: PP
authors.lastname: Singh
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D006632:Histamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006639:Histidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D051379:Mice; D010962:Plasmodium berghei / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D007093:Imidazoles; D006639:Histidine; C007749:2-fluorohistidine; C029899:imidazole; D006632:Histamine; D002738:Chloroquine