title: C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.
abstract: Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.
authors.affiliation: Laboratory of Molecular Microbiology, Dept. of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain.
authors.forename: Carmen P
authors.initials: CP
authors.lastname: Alvarez
authors.forename: Fátima
authors.initials: F
authors.lastname: Lasala
authors.forename: Jaime
authors.initials: J
authors.lastname: Carrillo
authors.forename: Oscar
authors.initials: O
authors.lastname: Muñiz
authors.forename: Angel L
authors.initials: AL
authors.lastname: Corbí
authors.forename: Rafael
authors.initials: R
authors.lastname: Delgado
mesh_terms: D015815:Cell Adhesion Molecules; D003713:Dendritic Cells / Q000378:metabolism; D029043:Ebolavirus / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D019169:Jurkat Cells; D037102:Lectins / Q000378:metabolism*; D037181:Lectins, C-Type; D009000:Monocytes; D011946:Receptors, Antigen / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D014771:Virion / Q000378:metabolism; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D037102:Lectins; D037181:Lectins, C-Type; D011946:Receptors, Antigen; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C433029:CLEC4M protein, human