Genetic dissection of common diseases.
The complex genetic nature of many common diseases makes the identification of the genes that predispose to these ailments a difficult task. In this review we discuss the elements that contribute to the complexity of polygenic diseases and describe an experimental strategy for disease-related gene discovery that attempts to overcome these factors. This strategy involves a population-based case-control paradigm and makes use of a highly informative, homogeneous founder population, many of whose members presently reside in Israel. The properties of single nucleotide polymorphisms, which are presently the markers of choice, are discussed, and the technologies that are currently available for SNP genotyping are briefly presented.
Zak
Naomi B
NB
IDgene Pharmaceutical Ltd. Jerusalem, Israel. naomiz@idgene.com
Shifman
Sagiv
S
Shalom
Anne
A
Darvasi
Ariel
A
D016022:Case-Control Studies; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007557:Israel; D007585:Jews / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*