Trans-regulation of epidermal growth factor receptor by lysophosphatidic acid and G protein-coupled receptors.
Lysophosphatidic acid (LPA) is known to induce protein tyrosine phosphorylation and has growth factor-like effects. In the last several years, the epidermal growth factor (EGF) receptor has been recognized as a protein tyrosine kinase that plays a central role in mediating LPA-induced tyrosine phosphorylation and Erk MAP kinase activation. In this article, we review recent progress in the study of trans-regulation of EGF receptor by LPA and G protein-coupled receptors (GPCR) and discuss the gap in our knowledge of the mechanism by which LPA induces EGF receptor activation.
Wu
Jie
J
Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. wu@moffitt.usf.edu
Cunnick
Jess M
JM
D000818:Animals; D066246:ErbB Receptors / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D008246:Lysophospholipids; D011956:Receptors, Cell Surface; D066246:ErbB Receptors; D019204:GTP-Binding Proteins