title: The decline of pulmonary function among patients with chronic asthma treated with inhaled corticosteroid.
abstract: We analyzed the rate of decline of pulmonary function annually over 2 years in 49 patients with chronic asthma, who were being treated with inhaled corticosteroid (beclomethasone). The coefficient of linear regression of pulmonary function based on dose of inhaled corticosteroid may be used to track the exact rate of the decline of pulmonary function. The declining rate of pulmonary function is faster in the early stages of the disease, in spite of the treatment with inhaled beclomethasone. In chronic asthmatics, the distal airway units appear to deteriorate, and the extent of deterioration probably changes with the progression of the disease.
authors.affiliation: First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan. tan-tym@umin.ac.jp
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hoshino
authors.forename: Masashi
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000280:Administration, Inhalation; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001249:Asthma / Q000503:physiopathology*; D001507:Beclomethasone / Q000008:administration & dosage*; D002908:Chronic Disease; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests
chemical_list: D000893:Anti-Inflammatory Agents; D001507:Beclomethasone