title: Effects of Kampo herbal medicine on plasma melatonin concentration in patients.
abstract: There are studies reporting that some natural products containing melatonin. Sleep disturbance and nocturnal polyuria are related to abnormal biorhythm. It is possible that kampo medicine may influence biorhythm. We therefore examined the symptoms and plasma melatonin of patients treated with rokumi-gan, hachimi-jio-gan, gosha-jinki-gan and seishinrenshi-in. Furthermore, the concentration of four kampo medicines and crude drugs making up these formulations were investigated. Diurnal plasma melatonin was not affected by Rokumi-gan, but tended to be lowered by treatment with hachimi-jio-gan, gosha-jinki-gan and seishinrenshi-in. Melatonin was present in several extracts from crude drugs, namely Rehmanniae radix, Moutan cortex, Cinnamomi cortex, Aconiti tuber, Plantaginis semen, Scutellariae radix and Lycii radicis cortex.
authors.affiliation: Department of Bioregulatory Function, University of Tokyo Graduate School of Medicine, Japan.
authors.forename: Hareka
authors.initials: H
authors.lastname: Watanabe
authors.forename: Takao
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Meibou
authors.initials: M
authors.lastname: Tomii
authors.forename: Yuki
authors.initials: Y
authors.lastname: Sekiguchi
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Uchida
authors.forename: Tadashi
authors.initials: T
authors.lastname: Aoki
authors.forename: Jong-Chol
authors.initials: JC
authors.lastname: Cyong
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D020835:Medicine, Kampo; D008550:Melatonin / Q000097:blood*; D008875:Middle Aged; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology; D014570:Urologic Diseases / Q000097:blood / Q000188:drug therapy
chemical_list: D010936:Plant Extracts; D008550:Melatonin