No linkage of the interleukin-4 receptor locus on chromosome 16p11.2-12.1 with sarcoidosis in German multiplex families.
We typed 241 members of 62 sarcoidosis families with 136 affected siblings for three single nucleotide polymorphisms of the interleukin-4 receptor alpha-chain gene (IL4R). Allele frequencies in patients were compared to those of healthy unrelated control individuals. The segregation of the three-point IL4R haplotypes completed by two flanking highly polymorphic microsatellite polymorphisms revealed no evidence for linkage of the IL4R gene locus with sarcoidosis.
Bohnert
A
A
Institute of Clinical Immunology and Transfusion Medicine, Justus-Liebig-University Giessen, Giessen, Germany. anette.bohnert@immunologie.med.uni-giessen.de
Schürmann
M
M
Hartung
A
A
Hackstein
H
H
Müller-Quernheim
J
J
Bein
G
G
D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D008040:Genetic Linkage; D005858:Germany; D006801:Humans; D019948:Receptors, Interleukin-4 / Q000235:genetics*; D012507:Sarcoidosis / Q000235:genetics*
D019948:Receptors, Interleukin-4