Generalized pustular and erythrodermic psoriasis associated with bupropion treatment.
Severe drug eruptions may cause diagnostic and therapeutic difficulty when they mimic or provoke endogenous patterns of dermatosis. We report three patients with known psoriasis in whom use of bupropion (Zyban), prescribed to assist with cessation of smoking, led to severe pustular or erythrodermic exacerbation of psoriasis within 3-5 weeks. All patients were systemically unwell and required hospitalization to control the disease flare.
Cox
N H
NH
Department of Dermatology, Cumberland Infirmary, Carlisle CA2 7HY, UK. Neil.Cox@ncumbria-acute.nhs.uk
Gordon
P M
PM
Dodd
H
H
D000328:Adult; D016642:Bupropion / Q000009:adverse effects*; D003873:Dermatitis, Exfoliative / Q000139:chemically induced*; D018765:Dopamine Uptake Inhibitors / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000139:chemically induced*; D016540:Smoking Cessation / Q000379:methods*
D018765:Dopamine Uptake Inhibitors; D016642:Bupropion