[Modification of breath sample alcohol level kinetics resulting from the association of citric acid and fructose].
To show the effect, before the ingestion of alcohol, of orally absorbing a concentrated aqueous solution of fructose and citric acid (SACF) upon the kinetics of breath sample alcohol levels (BSAL) in a young, healthy, male volunteer.


METHODS
14 volunteers consumed alcohol after an overnight fast in the form of whisky 0.49 g/kg body weight. The BSAL were determined between 0 and 150 minutes after ingestion of alcohol. For each volunteer two trials were carried out, one 5 minutes after the ingestion of 50 mL of water, and one 5 minutes after the ingestion of 50 mL of SCAF. The differents kinetics of the BSAL of the two trials were compared.


RESULTS
each time the measurements of BSAL with SCAF was inferior to that without SACF (p < 0.002). The Cmax with SCAF was inferior (by about 35%) to that without SCAF (p < 0.001). The Tmax with SCAF was about twice that without SACF (p < 0.001). There was no significant difference in the speed of decrease in BSAL.


CONCLUSIONS
for the level of consumption of alcohol tested the SCAF allows the rise in BSAL to be limited (and delayed). The article discusses the reasons for this action, essentially caused by a slowing down of gastric emptying resulting from the citric acid. The latter also allows, in this way, an increase in the effect of the first gastric passage of ethanol.
Ernouf
D
D
Laboratoire de toxicologie, Faculté de pharmacie, 31, avenue Monge, 37200 Tours, France.
Lejeune
B
B
D000328:Adult; D000428:Alcohol Drinking / Q000378:metabolism*; D001944:Breath Tests; D019343:Citric Acid / Q000378:metabolism*; D000431:Ethanol / Q000032:analysis*; D005632:Fructose / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D013997:Time Factors
D019343:Citric Acid; D005632:Fructose; D000431:Ethanol
Modifications de la cinétique de l'alcool dans l'air expiré par l'association acide citrique-fructose.