title: In vivo sonoluminescence imaging with the assistance of FCLA.
abstract: In this paper, sonoluminescence of tissues is reported for the first time. A sonoluminescence image of a living animal was obtained with a high-sensitivity imaging system. Furthermore, to enhance biological sonoluminescence, fluoresceinyl Cypridina luminescent analogue (FCLA), a chemiluminescence analysis agent, was used in the experiment. With the assistance of FCLA we succeeded in observing an image of a living animal with high contrast and good signal-to-noise ratio. This technique has potential applications in clinical diagnosis.
authors.affiliation: Institute of Laser Life Science, South China Normal University, Guangzhou, People's Republic of China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: He
authors.forename: Da
authors.initials: D
authors.lastname: Xing
authors.forename: Shici
authors.initials: S
authors.lastname: Tan
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Tang
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Ueda
mesh_terms: D000162:Acoustics / Q000295:instrumentation*; D000818:Animals; D003952:Diagnostic Imaging; D005452:Fluoresceins / Q000494:pharmacology*; D005609:Free Radicals; D007093:Imidazoles / Q000494:pharmacology*; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010100:Oxygen / Q000378:metabolism; D013016:Sound; D013997:Time Factors; D014159:Transducers; D014465:Ultrasonics
chemical_list: D005452:Fluoresceins; D005609:Free Radicals; D007093:Imidazoles; C080213:3,7-dihydro-6-(4-(2-(N'-(5-fluoresceinyl)thioureido)ethoxy)phenyl)-2-methylimidazo-(1,2-a)pyrazin-3-one; D010100:Oxygen