title: [Induced interstitial pneumonitis: role of pegylated interferon alpha 2b].
abstract: Pulmonary complications of alpha interferon are rare. We report two cases of lung complications in liver transplantation patients for HCV related cirrhosis. After switching from interferon alpha to pegylated interferon alpha 2b, one patient developed a BOOP (Bronchiolitis Obliterans Organizing Pneumonia) and the other severe interstitial pneumonitis. We discuss the causes of these rare pulmonary alpha-interferon induced complications and the different way to suggest that the pegylated interferon alpha 2b could be related to the risk of pulmonary toxicity of this treatment.
authors.affiliation: Fédération des Spécialités Digestives, Hôpital Edouard Herriot, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Rocca
authors.forename: Jérôme
authors.initials: J
authors.lastname: Dumortier
authors.forename: Philippe
authors.initials: P
authors.lastname: Tanière
authors.forename: Serge
authors.initials: S
authors.lastname: Duperret
authors.forename: Thierry
authors.initials: T
authors.lastname: Vial
authors.forename: Vincent
authors.initials: V
authors.lastname: Cottin
authors.forename: Bertrand
authors.initials: B
authors.lastname: Delafosse
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Scoazec
authors.forename: Olivier
authors.initials: O
authors.lastname: Boillot
mesh_terms: D000328:Adult; D006526:Hepatitis C / Q000473:pathology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects*; D008103:Liver Cirrhosis / Q000601:surgery; D016031:Liver Transplantation; D008168:Lung / Q000187:drug effects; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols; D011994:Recombinant Proteins
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C417083:peginterferon alfa-2b; C100416:peginterferon alfa-2a
vernacular_title: Forme pegylée de l'interféron alpha 2b et pneumopathies interstitielles diffuses.