title: Medulloblastomas in neurofibromatosis type 1. Case report and literature review.
abstract: A 6-year-old girl, previously diagnosed with neurofibromatosis type 1 (NF-1) presented with ataxia and symptoms of raised intracranial pressure. Diagnostic work up disclosed a posterior fossa tumor. Histopathological study of the excised neoplasm showed a cerebellar medulloblastoma. We review the current literature and suggest that the association of medulloblastoma with NF-1 is not a chance occurrence, and that it might be pathogenically related. We propose that medulloblastoma should be added to the list of malignancies that are apt to occur in NF-1.
authors.affiliation: Unidad de Neurocirugía Pediátrica, Servicio Regional de Neurocirugía, Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia.
authors.forename: J F
authors.initials: JF
authors.lastname: Martínez-Lage
authors.forename: C
authors.initials: C
authors.lastname: Salcedo
authors.forename: M
authors.initials: M
authors.lastname: Corral
authors.forename: M
authors.initials: M
authors.lastname: Poza
mesh_terms: D001259:Ataxia / Q000209:etiology; D002648:Child; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D003399:Craniotomy; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000601:surgery; D015192:Infratentorial Neoplasms / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D019586:Intracranial Hypertension / Q000209:etiology; D008527:Medulloblastoma / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D009456:Neurofibromatosis 1 / Q000473:pathology*; D017287:Ventriculoperitoneal Shunt