[Interactions of a DNA molecule with coordination compounds of platinum and cobalt in solutions].
The interaction of DNA with coordination compounds of divalent platinum and trivalent cobalt was studied. Complexes containing simultaneously different coordination compounds were prepared by various procedures. It was shown that the binding of trans-diaminodichloroplatinum (DDP) to DNA prevents its further complexing with cis-DDP, while in the presence of cis-DDP the possibility for trans-DDP to bind to DNA in solution remains. The study of similar DNA complexes with trans-DDP and cobalt hexamine indicated the competition for the binding sites of these compounds to the DNA molecule.
Kas'ianenko
N A
NA
Physical Department, St. Petersburg State University, Ul'yanovskaya ul., 1, Petrodvorets, 198904 Russia.
Bogdanov
A A
AA
Defrenne
C
C
D000970:Antineoplastic Agents / Q000737:chemistry*; D002942:Circular Dichroism; D002945:Cisplatin / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D012996:Solutions; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D012996:Solutions; C030862:cobalt ammonium complex; D003035:Cobalt; D004247:DNA; D002945:Cisplatin
Vzaimodeĭstvie molekuly DNK s koordinatsionnymi soedineniiami platiny i kobal'ta v rastvore.