title: Salmon calcitonin - a potent inhibitor of food intake in states of impaired leptin signalling in laboratory rodents.
abstract: To compare the anorectic effectiveness of leptin and the amylin analogue salmon calcitonin (sCT), rodents were treated on 1 day with subcutaneous injections. In chow-fed C57Bl/6J mice, leptin and sCT reduced energy intake and acted additively. After C57Bl/6J mice had become leptin-resistant on being fed chocolate as a palatable high-caloric supplement to chow, their sCT-induced decrease in energy intake was more pronounced than in chow-fed mice with differential changes in the intake of chocolate (strong reduction) and chow (slight increase). Dose-response relationships for sCT-induced reductions in energy intake were analysed in chow-fed C57Bl/6J mice and two obese strains, ob/ob mice and melanocortin-4 receptor knockout (MC4-r-KO) mice, as well as in wild-type and fatty (fa/fa) rats. Compared to C57Bl/6J mice, reduction in food intake induced by sCT was attenuated in MC4-r-KO mice, and nearly absent in ob/ob mice, over the dose range investigated. Compared to C57Bl/6J mice, wild-type rats responded more sensitively to sCT and its efficiency was only slightly reduced in fatty (fa/fa) rats. Thus, while genetically induced failures of leptin signalling reduce the action of sCT, it effectively inhibits the intake of a palatable, high fat-high sugar diet even in states of diet-induced obesity with functional leptin resistance.
authors.affiliation: Max-Planck-Institut fuer physiologische und klinische Forschung, W.G. Kerckhoff-Institut, Parkstr.1, D-61231 Bad Nauheim, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Eiden
authors.forename: Carolin
authors.initials: C
authors.lastname: Daniel
authors.forename: Alexandra
authors.initials: A
authors.lastname: Steinbrueck
authors.forename: Ingrid
authors.initials: I
authors.lastname: Schmidt
authors.forename: Eckhart
authors.initials: E
authors.lastname: Simon
mesh_terms: D000818:Animals; D015992:Body Mass Index; D002116:Calcitonin / Q000494:pharmacology*; D004032:Diet; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D005260:Female; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008820:Mice, Obese; D051381:Rats; D011919:Rats, Inbred Strains; D044105:Receptor, Melanocortin, Type 4; D018043:Receptors, Corticotropin / Q000172:deficiency / Q000235:genetics; D054411:Receptors, Leptin; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D007328:Insulin; D020738:Leptin; D044105:Receptor, Melanocortin, Type 4; D018043:Receptors, Corticotropin; D054411:Receptors, Leptin; C515447:leptin receptor, mouse; C028815:salmon calcitonin; D002116:Calcitonin