title: [Spectrum of antibodies to HCV antigens in patients with different clinical patterns of chronic HCV infection].
abstract: Correlations between the spectra of antibodies to HCV proteins represented by various antigenic determinants and clinical variants of chronic HCV infection were studied. Synthetic peptides core-16, NS4-20, and NS5-23 simulating the immunodominant regions of the core, NS4 and NS5 proteins and recombinant proteins core-114 and NS4-86 were used as antigens. The results indicate that if the serum of an HCV patients contains no IgG to both antigenic determinants of NS4 or to NS5 in combination with any core antigenic determinant, a clinical and biochemical remission is highly probable. Chronic hepatitis C is characterized by the presence of IgG in high titers to both antigenic determinants of NS4 protein, particularly in combination with anti-NS5 IgG in low titers or none at all, or high titers of anti-core-16 IgG in combination with high titers of anti-NS4-20 IgG.
authors.forename: I V
authors.initials: IV
authors.lastname: Kruglov
authors.forename: O O
authors.initials: OO
authors.lastname: Znoĭko
authors.forename: O L
authors.initials: OL
authors.lastname: Ogienko
authors.forename: M V
authors.initials: MV
authors.lastname: Ianina
authors.forename: M P
authors.initials: MP
authors.lastname: Finogenova
authors.forename: T I
authors.initials: TI
authors.lastname: Alekseenkova
authors.forename: D M
authors.initials: DM
authors.lastname: Braginskiĭ
authors.forename: S N
authors.initials: SN
authors.lastname: Kuzin
authors.forename: L L
authors.initials: LL
authors.lastname: Sukhanova
authors.forename: A A
authors.initials: AA
authors.lastname: Grinev
authors.forename: N A
authors.initials: NA
authors.lastname: Selivanov
authors.forename: N V
authors.initials: NV
authors.lastname: Doroshenko
authors.forename: V A
authors.initials: VA
authors.lastname: Shibnev
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Semiletov
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D005260:Female; D016174:Hepacivirus / Q000276:immunology* / Q000302:isolation & purification; D018937:Hepatitis C Antibodies / Q000097:blood*; D018936:Hepatitis C Antigens / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000097:blood / Q000276:immunology* / Q000821:virology; D006801:Humans; D016056:Immunodominant Epitopes / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D014758:Viral Core Proteins / Q000276:immunology; D017361:Viral Nonstructural Proteins / Q000276:immunology; D012324:RNA-Dependent RNA Polymerase
chemical_list: D000410:Alanine Transaminase; D018937:Hepatitis C Antibodies; D018936:Hepatitis C Antigens; D016056:Immunodominant Epitopes; D007074:Immunoglobulin G; D010455:Peptides; D012367:RNA, Viral; D014758:Viral Core Proteins; D017361:Viral Nonstructural Proteins; C093542:NS4 protein, hepatitis C virus; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase
vernacular_title: Spektr antitel k razlichnym antigenam HCV pri raznykh variantakh techeniia khronicheskoĭ HCV-infektsii.