title: A method for measuring oxygen distributions in tissue using frequency domain phosphorometry.
abstract: Phosphorescence lifetime of phosphors dissolved in biological fluids is dependent on the local oxygen concentration. When phosphor is added to the blood in vivo there is a distribution of lifetimes due to the distribution of oxygen concentrations in the blood of the sampled tissue volume. The distribution of oxygen can be assessed non-invasively and in practically real-time using frequency domain time-resolved phosphorometry. Here we describe a multi-frequency system for measurements of oxygen distributions in tissue in vivo.
authors.affiliation: Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. vinograd@mail.med.upenn.edu
authors.forename: Sergei A
authors.initials: SA
authors.lastname: Vinogradov
authors.forename: Maria A
authors.initials: MA
authors.lastname: Fernandez-Seara
authors.forename: Benjamin W
authors.initials: BW
authors.lastname: Dupan
authors.forename: David F
authors.initials: DF
authors.lastname: Wilson
mesh_terms: D019277:Entropy; D008163:Luminescent Measurements; D008433:Mathematics; D010100:Oxygen / Q000032:analysis* / Q000378:metabolism*; D012984:Software; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods*
chemical_list: D010100:Oxygen