A case of azoospermia in a bull carrying a Y-autosome reciprocal translocation.
During normal cytogenetic investigations on the Chianina cattle (BTA) breed, a normal looking young bull was found to carry an abnormal Y chromosome which was a product of a reciprocal translocation between chromosomes Y and 9. This was revealed by both CBA- and RBG-banding techniques and was clearly confirmed by FISH-mapping analysis with IDVGA50 (which paints the complete Yq arm in a normal Y), as well as with AMD1, CGA, IGF2R (mapping to BTA9q16, BTA9q22 and BTA9q27-->q28, respectively) and SRY (mapping to normal BTAYq23). Analysis on sperm from four different samples revealed azoospermia in the carrier, indicating that the rcp(Y;9) induces sterility in the bull.
Iannuzzi
L
L
National Research Council (CNR), IABBAM, Laboratory of Animal Cytogenetics and Gene Mapping, Naples, Italy. L.Iannuzzi@iabbam.na.cnr.it
Molteni
L
L
Di Meo
G P
GP
De Giovanni
A
A
Perucatti
A
A
Succi
G
G
Incarnato
D
D
Eggen
A
A
Cribiu
E P
EP
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics*; D002871:Chromosome Banding; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009845:Oligospermia / Q000235:genetics* / Q000662:veterinary*; D014178:Translocation, Genetic / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics*