title: Side-chain homologation of nodulisporic acid: synthesis of potent new dienyl derivatives.
abstract: A series of new, diene-modified nodulisporic acid analogues (2) bearing diverse functionality at the 3"- and 4"-sites was efficiently prepared from the 3"-aldehyde 3. Biological evaluation of these synthetic nodulisporic acid analogues for systemic flea efficacy identified potent compounds and further clarified the structural requirements for ectoparasite activity.
authors.affiliation: Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.
authors.forename: Dong
authors.initials: D
authors.lastname: Ok
authors.forename: Chunshi
authors.initials: C
authors.lastname: Li
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Shih
authors.forename: Steve
authors.initials: S
authors.lastname: Salva
authors.forename: Michelle B
authors.initials: MB
authors.lastname: Ayer
authors.forename: Steven L
authors.initials: SL
authors.lastname: Colletti
authors.forename: Prasun K
authors.initials: PK
authors.lastname: Chakravarty
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Wyvratt
authors.forename: Michael H
authors.initials: MH
authors.lastname: Fisher
authors.forename: Lynn
authors.initials: L
authors.lastname: Gregory
authors.forename: Michelle
authors.initials: M
authors.lastname: Zakson-Aiken
authors.forename: Wesley L
authors.initials: WL
authors.lastname: Shoop
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Schmatz
authors.forename: Peter T
authors.initials: PT
authors.lastname: Meinke
mesh_terms: D000818:Animals; D002417:Cattle; D004478:Ectoparasitic Infestations / Q000188:drug therapy; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry; D005423:Siphonaptera; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D007211:Indoles; D007306:Insecticides; C110703:nodulisporic acid A