title: Synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives potassium channel openers.
abstract: As part of a search for new potassium channel openers, the synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives derived from transformation of the benzopyran skeleton of cromakalim were described. Several new 1,4-benzoxazine derivatives were provided with significant vasorelaxant activity with an overall pharmacological behavior similar to CRK (1f, 1i, 2d, 2e, 2f and 2i).
authors.affiliation: Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy. caliendo@unina.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Caliendo
authors.forename: Elisa
authors.initials: E
authors.lastname: Perissutti
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Santagada
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Fiorino
authors.forename: Beatrice
authors.initials: B
authors.lastname: Severino
authors.forename: Roberta d'Emmanuele
authors.initials: Rd
authors.lastname: di Villa Bianca
authors.forename: Laura
authors.initials: L
authors.lastname: Lippolis
authors.forename: Aldo
authors.initials: A
authors.lastname: Pinto
authors.forename: Raffaella
authors.initials: R
authors.lastname: Sorrentino
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects; D019806:Cromakalim; D004305:Dose-Response Relationship, Drug; D015640:Ion Channel Gating / Q000187:drug effects; D008297:Male; D010078:Oxazines / Q000138:chemical synthesis* / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D010078:Oxazines; D015221:Potassium Channels; D019806:Cromakalim