[Ototoxic effect and its prevention in administration of cisplatin].
Short-latent acoustic evoked potentials were registered in examination of hearing function in guinea pigs given platinum compounds. A protective action of thiol compounds (sodium thiosulfate and unitiol) was tried in relation to hypoacusis induced by cisplatinum.
Bogomil'skiĭ
M R
MR
D'iakonova
I N
IN
Poliakov
V G
VG
Rakhmanova
I V
IV
Stakhovskaia
O A
OA
Tikhomirov
A M
AM
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002614:Chelating Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002945:Cisplatin / Q000009:adverse effects*; D005260:Female; D006168:Guinea Pigs; D006311:Hearing Disorders / Q000139:chemically induced* / Q000517:prevention & control*; D013885:Thiosulfates / Q000008:administration & dosage / Q000627:therapeutic use*; D014494:Unithiol / Q000008:administration & dosage / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D002614:Chelating Agents; D013885:Thiosulfates; D014494:Unithiol; C017717:sodium thiosulfate; D002945:Cisplatin
Ototoksicheskoe deĭstvie tsisplatina i vozmozhnosti ego profilaktiki.