Calcium channel mutations and migraine.
An increasing number of mutations in the CACNA1A gene have been identified, which are associated with a broad clinical spectrum, including familial hemiplegic migraine. Transfection studies and mouse model analyses are currently being undertaken to study the correlation between CACNA1A mutations and disease.
Kors
Esther E
EE
Department of Neurology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands.
van den Maagdenberg
Arn M J M
AM
Plomp
Jaap J
JJ
Frants
Rune R
RR
Ferrari
Michel D
MD
D000818:Animals; D001923:Brain Chemistry / Q000235:genetics*; D015220:Calcium Channels / Q000235:genetics* / Q000378:metabolism; D020864:Calcium Channels, N-Type; D020865:Calcium Channels, P-Type; D020907:Calcium Channels, Q-Type; D004195:Disease Models, Animal; D004827:Epilepsy / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D051379:Mice; D008881:Migraine Disorders / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D009154:Mutation / Q000235:genetics*; D010641:Phenotype; D009435:Synaptic Transmission / Q000235:genetics
D015220:Calcium Channels; D020864:Calcium Channels, N-Type; D020865:Calcium Channels, P-Type; D020907:Calcium Channels, Q-Type; C105656:CACNA1A protein, human