Submillimeter-wave phonon modes in DNA macromolecules.
A detailed investigation of phonon modes in DNA macromolecules is presented. This work presents experimental evidence to confirm the presence of multiple dielectric resonances in the submillimeter-wave spectra (i.e., approximately 0.01-10 THz) obtained from DNA samples. These long-wave (i.e., approximately 1-30 cm(-1)) absorption features are shown to be intrinsic properties of the particular DNA sequence under study. Most importantly, a direct comparison of spectra between different DNA samples reveals a large number of modes and a reasonable level of sequence-specific uniqueness. This work establishes the initial foundation for the future use of submillimeter-wave spectroscopy in the identification and characterization of DNA macromolecules.
Woolard
D L
DL
U.S. Army Research Laboratory, Army Research Office, Research Triangle Park, North Carolina 27709, USA.
Globus
T R
TR
Gelmont
B L
BL
Bykhovskaia
M
M
Samuels
A C
AC
Cookmeyer
D
D
Hesler
J L
JL
Crowe
T W
TW
Jensen
J O
JO
Jensen
J L
JL
Loerop
W R
WR
D001703:Biophysics / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D008962:Models, Theoretical; D009690:Nucleic Acid Conformation; D013057:Spectrum Analysis / Q000379:methods
D004247:DNA