Effects of Kampo herbal medicine on plasma melatonin concentration in patients.
There are studies reporting that some natural products containing melatonin. Sleep disturbance and nocturnal polyuria are related to abnormal biorhythm. It is possible that kampo medicine may influence biorhythm. We therefore examined the symptoms and plasma melatonin of patients treated with rokumi-gan, hachimi-jio-gan, gosha-jinki-gan and seishinrenshi-in. Furthermore, the concentration of four kampo medicines and crude drugs making up these formulations were investigated. Diurnal plasma melatonin was not affected by Rokumi-gan, but tended to be lowered by treatment with hachimi-jio-gan, gosha-jinki-gan and seishinrenshi-in. Melatonin was present in several extracts from crude drugs, namely Rehmanniae radix, Moutan cortex, Cinnamomi cortex, Aconiti tuber, Plantaginis semen, Scutellariae radix and Lycii radicis cortex.
Watanabe
Hareka
H
Department of Bioregulatory Function, University of Tokyo Graduate School of Medicine, Japan.
Kobayashi
Takao
T
Tomii
Meibou
M
Sekiguchi
Yuki
Y
Uchida
Kazuhide
K
Aoki
Tadashi
T
Cyong
Jong-Chol
JC
D005260:Female; D006801:Humans; D008297:Male; D020835:Medicine, Kampo; D008550:Melatonin / Q000097:blood*; D008875:Middle Aged; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology; D014570:Urologic Diseases / Q000097:blood / Q000188:drug therapy
D010936:Plant Extracts; D008550:Melatonin