Chemopreventive effects of emodin and cassiamin B in mouse skin carcinogenesis.
In continuation of our works of natural and synthetic products as cancer chemopreventive agents, we have examined emodin and cassiamin B, which were isolated from Cassia siamea. These compounds exhibited the remarkable anti-tumor promoting effect on two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter by both topical application. Furthermore, emodin exhibited potent inhibitory activity on two-stage carcinogenesis test of mouse skin tumors induced by nitric oxide donor, (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexeneamide as an initiator and TPA as a promoter.
Koyama
Junko
J
Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Higashinada, Kobe 658, Japan. j-koyama@kobepharma-u.ac.jp
Morita
Izumi
I
Tagahara
Kiyoshi
K
Nobukuni
Yoshitaka
Y
Mukainaka
Teruo
T
Kuchide
Masashi
M
Tokuda
Harukuni
H
Nishino
Hoyoku
H
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology*; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002366:Cassia; D004642:Emodin / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate; D013997:Time Factors
D000880:Anthraquinones; D016588:Anticarcinogenic Agents; D004791:Enzyme Inhibitors; C465122:cassiamin B; D015127:9,10-Dimethyl-1,2-benzanthracene; D004642:Emodin; D013755:Tetradecanoylphorbol Acetate