Assessment of thrombocytopenic disorders using the Platelet Function Analyzer (PFA-100).
The Platelet Function Analyzer (PFA-100) was used to measure platelet function in paediatric patients with destructive versus underproduction thrombocytopenia. Closure time (CT) and total volume (TV) measurements with standard 150 microm apertures discriminated between patients with similar platelet counts from 30 to 150 x 10(9)/l. However, at platelet counts < 30 x 10(9)/l, a 100-microm aperture (experimental) gave the best assessment of platelet function. TV results could be analysed even when CTs were indeterminate. Further investigations are warranted to more fully understand the relationships among platelet function as measured by the PFA-100 in standard/experimental modes, bleeding and transfusion outcome in thrombocytopenia.
Carcao
Manuel D
MD
Divisions of Haematology/Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
Blanchette
Victor S
VS
Stephens
Derek
D
He
Lijing
L
Wakefield
Cindy D
CD
Butchart
Sheila
S
Christie
Douglas J
DJ
Rand
Margaret L
ML
D000293:Adolescent; D001792:Blood Platelets / Q000502:physiology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D006801:Humans; D010976:Platelet Count; D010979:Platelet Function Tests / Q000379:methods*; D013921:Thrombocytopenia / Q000097:blood* / Q000209:etiology