[Antiphosphoplipid antibodies and retinal occlusive vasculopathy].
OBJECTIVE
to determine the prevalence of antiphospholipid antibodies in patients with occlusive retinal vascular events, exempt from conventional risk factors of retinal thrombosis.


METHODS
eleven patients with retinal vascular occlusion, free of main accepted risk factors for retinal thrombosis, were retrospectively screened for antiphospholipid antibodies (anticardiolipin and anti-beta2 glycoprotein 1 antibodies) by an Elisa method. Prevalence of antiphospholipid antibodies were compared with those in a homogenous control group of 100 patients.


RESULTS
the prevalence of antiphospholipid antibodies in the study group was 27% (three of 11). Comparison with control group prevalence (3%) showed a statistically significant difference (p < 0,001). One patient in the study disclosed positivity for IgG anticardiolipine antibodies, one for IgM anticardiolipine antibodies and one for anti-beta2 glycoprotein 1 antibodies.


CONCLUSIONS
our results lead us to recommend a systematic search for specific antiphospholipid antibodies in such young patients which could have an importance for the diagnosis of primary antiphospholipid syndrome.
Zitouni
M
M
Laboratoire d'immunologie, Hôpital La Rabta, Tunis, Tunisie, France.
Turki
F
F
Malouche
N
N
Kallel
M
M
Laadhar
L
L
Jeddi
A
A
Matri
L
L
Makni
S
S
D000293:Adolescent; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D002648:Child; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008875:Middle Aged; D012171:Retinal Vessels / Q000276:immunology* / Q000473:pathology*; D012189:Retrospective Studies
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Anticorps antiphospholipides et occlusion vasculaire rétinienne.