Biological activities and metabolism of the lysophosphoinositides and glycerophosphoinositols.
The lysophospholipids are integral components of the plasma membrane that have often been considered as side products of the phospholipase A2 (PLA2)-dependent production of arachidonic acid and the deacylation/reacylation processes involved in phospholipid homeostasis. Data indicating roles of these lipid derivatives in hormone responses and cell transformation have now led to a different view, and the understanding of their involvement in the modulation of cell function is building up. Here, we will summarise the current knowledge concerning the biological roles of the lysophosphoinositides and the glycerophosphoinositols (their fully deacylated counterparts) in the framework of their known effects, and those of the other lysophospholipids and glycerophospholipids.
Corda
Daniela
D
Department of Cell Biology and Oncology, Istituto di Ricerche Farmacologiche "Mario Negri", Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro, Chieti, Italy. corda@dcbo.negrisud.it
Iurisci
Cristiano
C
Berrie
Christopher P
CP
D000818:Animals; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism*; D008954:Models, Biological; D010716:Phosphatidylinositols / Q000378:metabolism / Q000502:physiology*
D008246:Lysophospholipids; D010716:Phosphatidylinositols; D020558:GTP Phosphohydrolases