title: [Aggressive lymphomas].
abstract: Treatment strategies of aggressive lymphoma are the subject of this review. Main regimens of chemotherapy are described, as well as prognostic factors that direct therapeutic decisions. First-line treatment modalities of localized and advanced disease are envisaged, including the role of high-dose therapy with hematopoietic support, as well as salvage treatment of failures. Finally, the recent and major impact of immunotherapy based on the CD20 monoclonal antibody is outlined.
authors.affiliation: Service d'hématologie clinique Hôpital Henri-Mondor, 94010 Créteil. corinne.haioun@hmn.ap-hop-paris.fr
authors.forename: Corinne
authors.initials: C
authors.lastname: Haioun
authors.forename: Félix
authors.initials: F
authors.lastname: Reyes
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011379:Prognosis; D016879:Salvage Therapy
chemical_list: D000911:Antibodies, Monoclonal
vernacular_title: Lymphomes agressifs.