title: Nef enhances human immunodeficiency virus type 1 infectivity in the absence of matrix.
abstract: Nef enhances the serine phosphorylation of the human immunodeficiency virus type 1 matrix (MA) protein, which suggests that MA may be a functional target of Nef. Using mutants that remain infectious despite the absence of most or all of MA, we show in the present study that the ability of Nef to enhance virus infectivity is not compromised even if MA is entirely replaced by a heterologous lipid anchor.
authors.affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.
authors.forename: Tatyana
authors.initials: T
authors.lastname: Dorfman
authors.forename: Elena
authors.initials: E
authors.lastname: Popova
authors.forename: Massimo
authors.initials: M
authors.lastname: Pizzato
authors.forename: Heinrich G
authors.initials: HG
authors.lastname: Göttlinger
mesh_terms: D002460:Cell Line; D017353:Gene Deletion; D015693:Gene Products, nef / Q000378:metabolism*; D015497:HIV-1 / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D010766:Phosphorylation; D013601:T-Lymphocytes / Q000821:virology; D014763:Viral Matrix Proteins / Q000235:genetics* / Q000378:metabolism; D054311:nef Gene Products, Human Immunodeficiency Virus
chemical_list: D015693:Gene Products, nef; D014763:Viral Matrix Proteins; D054311:nef Gene Products, Human Immunodeficiency Virus