title: Prevalence of TT virus in a CAPD population.
abstract: TT virus (TTV) has recently been identified in patients with post-transfusion non-A, non-G hepatitis. It is reported to be common in patients with a variety of liver diseases and with history of transfusion. Its pathogenesis in chronic liver diseases remains unclear. In this study, we have determined the prevalence of TTV in a continuous ambulatory peritoneal dialysis (CAPD) population and related its prevalence with history of previous hemodialysis, transfusion, HCV positivity and serum alanine amino-transferase (ALT) levels. TTV was detected in 44% of 63 CAPD patients and 30% of 43 healthy controls (p = 0.15). Frequency of TTV was similar in previously hemodialysed and never hemodialysed (8/14, 57% vs. 20/40, 41%, p = 0.15) and previously transfused and non-transfused (7/19, 37% vs. 15/44, 34%) CAPD patients. Prevalence of TTV was also similar in HCV(+) and HCV(-) patients. Serum ALT levels were 19 +/- 16 and 20 +/- 12 U/l in TTV(+) and TTV(-) patients, respectively. These results indicate that prevalence of TTV in a CAPD population is similar to healthy controls, and other routes of transmission in addition to parenteral routes might be involved in the transmission of TTV.
authors.affiliation: Division of Nephrology, Marmara University Medical School, Istanbul, Turkey.
authors.forename: I Cetin
authors.initials: IC
authors.lastname: Ozener
authors.forename: Filiz
authors.initials: F
authors.lastname: Ture
authors.forename: Mehmet
authors.initials: M
authors.lastname: Koc
authors.forename: Erol
authors.initials: E
authors.lastname: Avsar
mesh_terms: D000328:Adult; D000368:Aged; D001803:Blood Transfusion; D004266:DNA Virus Infections / Q000453:epidemiology*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000453:epidemiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000628:therapy / Q000821:virology*; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D015995:Prevalence; D022783:Torque teno virus