Therapeutic time window for YAG laser-induced reperfusion of thrombotic stroke in hypertensive rats.
We examined the novel YAG laser-induced reperfusion method in the photothrombotic middle cerebral artery (MCA) occlusion model in spontaneously hypertensive rats. In the 1 h ischemia group, infarct volume was significantly reduced to 41.1 +/- 15.6 mm3 compared with 81.6 +/- 18.3 mm3 in the no-reperfusion group. There were no significant differences in infarct volume among 2 h or 3 h ischemia and no-reperfusion groups. Three of six rats in the 3 h ischemia group showed hemorrhagic infarction. Our present results showed that recirculation must be instituted within 2 h of MCA occlusion to get beneficial effects in our model, supporting the concept of a narrow therapeutic time window for intervention in ischemic stroke.
Yao
Hiroshi
H
1Department of Medicine and Clinical Science (Second Department of Internal Medicine), Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
Okada
Yasushi
Y
Ibayashi
Setsuro
S
D000818:Animals; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D053685:Laser Therapy / Q000379:methods* / Q000639:trends; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D015427:Reperfusion Injury / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000379:methods* / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome