[Acne and hormones].
Androgens stimulate sebum production which is necessary for the development of acne. Acne in women may thus be considered as a manifestation of cutaneous androgenization. Most of acnes may be related to an idiopathic skin hyperandrogenism due to in situ enzyme activity and androgen receptor hypersensitivity, as also noted in idiopathic hirsutism. Some acne may correspond to elevated ovarian or adrenal androgen secretion. The presence of acne in women may lead to a diagnosis of functional hyperandrogenism, either polycysticovary syndrome or nonclassical 21-hydroxylase deficiency. Plasma level assays for testosterone, delta 4 androstenedione and 17-OH progesterone and ovarian echography are necessary to determine the possibility for an ovarian or adrenal hyperandrogenism, but not to better treat acne. The goal of hormonal therapy in acne is to oppose the effects of androgens on the sebaceous gland. Hormones may be used in female acne in the absence of endocrine abnormalities. Antiandrogens (cyproterone acetate or aldactone) may be useful in severe acne, hormonal contraceptives with cyproterone acetate or non androgenic progestins in mild or common acne often in association with other anti-acneic drugs. Glucocorticoids have to be administered in acne fulminans and other forms of acute, severe, inflammatory acne, for their anti-inflammatory properties.
Faure
Michel
M
Clinique dermatologique, Hôpital Edouard-Herriot 69347 Lyon. michel.faure@chu-lyon.fr
D000152:Acne Vulgaris / Q000188:drug therapy / Q000503:physiopathology*; D000726:Androgen Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D000728:Androgens / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006967:Hypersensitivity; D008297:Male; D011944:Receptors, Androgen / Q000502:physiology; D012627:Sebaceous Glands / Q000187:drug effects / Q000502:physiology; D012737:Sex Factors
D000726:Androgen Antagonists; D000728:Androgens; D005938:Glucocorticoids; D011944:Receptors, Androgen
Acné et hormones.