title: Antihistamines in the management of canine atopic dermatitis: a retrospective study of 171 dogs (1992-1998).
abstract: Antihistamines were prescribed for 178 of 271 dogs with a diagnosis of atopic dermatitis at the Veterinary Medical Teaching Hospital of the University of California, Davis from 1992 to 1998. Fifty-four percent of 166 dogs given antihistamines responded favorably to these treatments, with 27% of the responses rated as good and 27% rated as moderate. Diphenhydramine and hydroxyzine were the most commonly used antihistamines and were the most frequently effective. Chlorpheniramine and clemastine were administered less frequently and had much lower positive response rates. Responses to antihistamines as a group were significantly better in dogs having onset of clinical signs at younger ages (odds ratios for 1-year increase in age = 0.72, 95% confidence interval = 0.57 to 0.91, P =.005).
authors.affiliation: Koret Veterinary Teaching Hospital, School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.
authors.forename: Gila
authors.initials: G
authors.lastname: Zur
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Ihrke
authors.forename: Stephen D
authors.initials: SD
authors.lastname: White
authors.forename: Philip H
authors.initials: PH
authors.lastname: Kass
mesh_terms: D000485:Allergens / Q000009:adverse effects; D000818:Animals; D002744:Chlorpheniramine / Q000627:therapeutic use; D002974:Clemastine / Q000627:therapeutic use; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000662:veterinary*; D004155:Diphenhydramine / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy* / Q000209:etiology; D004285:Dogs; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006919:Hydroxyzine / Q000627:therapeutic use; D008297:Male; D011996:Records / Q000662:veterinary; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000485:Allergens; D006634:Histamine H1 Antagonists; D006919:Hydroxyzine; D002744:Chlorpheniramine; D004155:Diphenhydramine; D002974:Clemastine