Organometallic chemistry on solid phase. An overview.
Solid-phase organic synthesis (SPOS) is the most important method for the production of combinatorial libraries and with the development of high-throughput screening, libraries are widespread in pharmaceutical and agricultural chemistry. Amongst all the synthetic transformations successfully applied to solid phase, the use of organometallic reagents for the formation of a new carbon-carbon bond has been scarcely pursued. In this overview we collected the most recent examples of the use of organometallic reagents of Li, Mg, Cu, Zn, Si and B for C-C bond formation. The use of organometallic reagents in Pd-catalysed cross-coupling reactions was not reviewed. Highly basic organometallics as organo-lithium and -magnesium reagents have been more largely employed than cuprates and zincates, suggesting that several kinds of resins can withstand relatively strong reaction conditions.
Reginato
Gianna
G
CNR, Istituto di Chimica dei Composti Organo Metallici, Departimento di Chimica Organica Ugo Schiff, Polo Scientifico, Università degli Studi di Firenze, Sesto Fiorentino, Italy. gianna.reginato@unifi.it
Taddei
Maurizio
M
D001880:Boranes / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D009942:Organometallic Compounds / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry
D001880:Boranes; D009942:Organometallic Compounds; D012821:Silanes