Regional chemotherapy.
Regional chemotherapy is an interesting treatment option in patients with advanced pancreatic cancer but cannot be considered standard treatment, and it should not be performed outside controlled clinical trials. The real value of regional chemotherapy must be evaluated in larger, randomized trials. New drug combinations may reduce the observed side effects and improve tumor response. Gene therapy with p53 and K-ras modulated herpesviruses may become a palliative treatment option and can be administered easily by regional chemotherapy techniques [23].
Lorenz
Matthias
M
Department of General and Vascular Surgery, University Hospital of Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. M.Lorenz@em.uni-frankfurt.de
Heinrich
Stefan
S
D000230:Adenocarcinoma / Q000098:blood supply / Q000188:drug therapy*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D002445:Celiac Artery; D015687:Cell Hypoxia; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000009:adverse effects; D002986:Clinical Trials as Topic; D006440:Hemofiltration; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects; D017538:Mesenteric Artery, Superior; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D011788:Quality of Life; D012074:Remission Induction; D016896:Treatment Outcome
D000970:Antineoplastic Agents