[Effect of prostaglandin F2alpha on cells of the mammary gland alveoli in mice].
In studies on lactating laboratory mice an influence of prostaglandin F2 alpha on the value of transepithelial potential difference and resistance of the alveolar secretory epithelium in the mammary gland, was studied. Prostaglandin F2 alpha did not affect initial level of transepithelial potential difference and resistance in alveoles. In all experiments with the preliminary application of prostaglandin F2 alpha in different concentrations (1 x 10(-5)-1 x 10(-11) M) was registered a reliable increase in an amplitude (before 31 +/- 2%) and duration (before 43 +/- 3%) to return reactions on oxytocin. Prostaglandin F2 alpha caused a reduction of transepithelial resistance in the alveolar secretory epithelium of first phase to return reaction on oxytocin on 28 +/- 22%. The data obtained indicate a possibility of participation of prostaglandin F2 alpha in development of certain stages of shaping a composition of milk.
Markov
A G
AG
St. Petersburg State University, St. Petersburg, 199034, Universitetskaya Nab., 7/9, Russia.
Pariĭskaia
E N
EN
Tolkunov
Iu A
IuA
D000818:Animals; D015237:Dinoprost / Q000494:pharmacology* / Q000502:physiology; D004553:Electric Conductivity; D004594:Electrophysiology; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D005260:Female; D007774:Lactation; D008321:Mammary Glands, Animal / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D010121:Oxytocin / Q000494:pharmacology
D010121:Oxytocin; D015237:Dinoprost
Issledovanie vliiania prostaglandina F2al'fa na kletki al'veol molochnoĭ zhelezy mysheĭ.