[Persistent polyclonal B-cell lymphocytosis].
Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare and recently described entity. PPBL is diagnosed predominantly but not exclusively in women, usually smokers and is characterized by a moderate, chronic and absolute lymphocytosis (> 4 x 109/L). Peripheral blood examination show in all cases atypical binucleated lymphocytes. A polyclonal serum IgM is also associated and HLA-DR7 expression is present in most cases. The B cells are polyclonal with kappa and lambda light-chain expression. No clonal rearrangement of immunoglobulin heavy chain genes is observed. Finally, +i(3q) is a recurrent chromosomal abnormality and detected in 77% of cases with premature chromosome condensation in 50% and both abnormalities in 41% of cases. The benign clinical course of PPBL and lack of biological evolution in the majority of cases suggest that recognition is so important that aggressive therapy could be avoided.
Troussard
Laboratoire d'hématologie, CHU Côte-de-Nacre, 14000 Caen, France.
Mossafa
H
H
Flandrin
G
G
D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D015322:Gene Rearrangement, B-Lymphocyte; D005803:Genes, Immunoglobulin; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D007146:Immunoglobulin lambda-Chains / Q000097:blood; D008218:Lymphocytosis / Q000235:genetics* / Q000276:immunology*; D008297:Male; D012727:Sex Characteristics
D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains
Lymphocytose polyclonale avec lymphocytes sanguins binucléés.