title: MHC class I-dependent Vgamma4+ pulmonary T cells regulate alpha beta T cell-independent airway responsiveness.
abstract: Mice exposed to aerosolized ovalbumin (OVA) develop increased airway responsiveness when deficient in gammadelta T cells. This finding suggests that gammadelta T cells function as negative regulators. The regulatory influence of gammadelta T cells is evident after OVA-sensitization and -challenge, and after OVA-challenge alone, but not in untreated mice. With aerosolized Abs to target pulmonary T cells, we now demonstrate that negative regulation of airway responsiveness is mediated by a small subpopulation of pulmonary gammadelta T cells. These cells express Vgamma4 and depend in their function on the presence of IFN-gamma and MHC class I. Moreover, their effect can be demonstrated in the absence of alphabeta T cells. This novel type of negative regulation seems to precede the development of the adaptive, antigen-specific allergic response.
authors.affiliation: Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Lahn
authors.forename: Arihiko
authors.initials: A
authors.lastname: Kanehiro
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Takeda
authors.forename: Jennifer
authors.initials: J
authors.lastname: Terry
authors.forename: Youn-Soo
authors.initials: YS
authors.lastname: Hahn
authors.forename: M Kemal
authors.initials: MK
authors.lastname: Aydintug
authors.forename: Anatole
authors.initials: A
authors.lastname: Konowal
authors.forename: Koichi
authors.initials: K
authors.lastname: Ikuta
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: O'Brien
authors.forename: Erwin W
authors.initials: EW
authors.lastname: Gelfand
authors.forename: Willi K
authors.initials: WK
authors.lastname: Born
mesh_terms: D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D008168:Lung / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology*; D014132:Trachea / Q000276:immunology*
chemical_list: D017931:DNA Primers; D015395:Histocompatibility Antigens Class I